Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000119-TA|BGIBMGA000119-PA|IPR000860|Porphobilinogen
deaminase
(407 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q0IEI9 Cluster: Porphobilinogen deaminase; n=4; Coeloma... 366 e-100
UniRef50_Q9W0G4 Cluster: CG9165-PA; n=6; Coelomata|Rep: CG9165-P... 364 3e-99
UniRef50_UPI0000D563F8 Cluster: PREDICTED: similar to CG9165-PA;... 363 3e-99
UniRef50_UPI0000DB6D6A Cluster: PREDICTED: similar to Porphobili... 360 3e-98
UniRef50_P08397 Cluster: Porphobilinogen deaminase; n=50; Eutele... 315 1e-84
UniRef50_Q8YVU6 Cluster: Porphobilinogen deaminase; n=42; Bacter... 314 4e-84
UniRef50_UPI0000583C22 Cluster: PREDICTED: hypothetical protein;... 284 3e-75
UniRef50_Q7U5C2 Cluster: Porphobilinogen deaminase; n=24; Bacter... 277 4e-73
UniRef50_Q54P93 Cluster: Porphobilinogen deaminase; n=1; Dictyos... 255 1e-66
UniRef50_P16616 Cluster: Porphobilinogen deaminase; n=22; Bacill... 250 4e-65
UniRef50_Q6C097 Cluster: Porphobilinogen deaminase; n=10; Ascomy... 248 2e-64
UniRef50_Q09899 Cluster: Porphobilinogen deaminase; n=1; Schizos... 247 4e-64
UniRef50_P28789 Cluster: Porphobilinogen deaminase; n=9; Ascomyc... 244 3e-63
UniRef50_O94048 Cluster: Porphobilinogen deaminase; n=4; Ascomyc... 243 6e-63
UniRef50_Q6BM23 Cluster: Porphobilinogen deaminase; n=6; Sacchar... 243 8e-63
UniRef50_Q4T5L1 Cluster: Chromosome undetermined SCAF9206, whole... 241 2e-62
UniRef50_Q5WEP5 Cluster: Porphobilinogen deaminase; n=2; Firmicu... 239 7e-62
UniRef50_Q2RJ26 Cluster: Porphobilinogen deaminase; n=2; Clostri... 236 7e-61
UniRef50_Q5KWK6 Cluster: Porphobilinogen deaminase; n=32; Bacill... 236 9e-61
UniRef50_Q75DY0 Cluster: Porphobilinogen deaminase; n=7; Ascomyc... 233 6e-60
UniRef50_Q9KVM1 Cluster: Porphobilinogen deaminase; n=57; Gammap... 232 1e-59
UniRef50_P46355 Cluster: Porphobilinogen deaminase; n=144; Bacte... 228 2e-58
UniRef50_Q602K3 Cluster: Porphobilinogen deaminase; n=26; cellul... 228 2e-58
UniRef50_Q8XWW3 Cluster: Porphobilinogen deaminase; n=71; Proteo... 226 9e-58
UniRef50_Q0UDH2 Cluster: Putative uncharacterized protein; n=1; ... 225 1e-57
UniRef50_O66621 Cluster: Porphobilinogen deaminase; n=2; Aquifex... 222 1e-56
UniRef50_Q2LQU2 Cluster: Porphobilinogen deaminase; n=1; Syntrop... 221 4e-56
UniRef50_Q1Q7D2 Cluster: Strongly similar to hydroxymethylbilane... 219 1e-55
UniRef50_Q3E1E4 Cluster: Porphobilinogen deaminase; n=3; Chlorof... 219 1e-55
UniRef50_A1WVT9 Cluster: Porphobilinogen deaminase; n=5; Gammapr... 217 6e-55
UniRef50_Q1QEM1 Cluster: Porphobilinogen deaminase; n=2; Psychro... 215 2e-54
UniRef50_Q8KCJ4 Cluster: Porphobilinogen deaminase; n=11; Chloro... 215 2e-54
UniRef50_A2Q9P7 Cluster: Catalytic activity: 4 porphobilinogen+H... 213 5e-54
UniRef50_Q0EWI8 Cluster: Porphobilinogen deaminase; n=2; Proteob... 213 7e-54
UniRef50_UPI00006CBE06 Cluster: porphobilinogen deaminase family... 213 9e-54
UniRef50_A3CL78 Cluster: Porphobilinogen deaminase, putative; n=... 210 7e-53
UniRef50_A0DD68 Cluster: Chromosome undetermined scaffold_46, wh... 205 2e-51
UniRef50_A1DGB8 Cluster: Porphobilinogen deaminase; n=1; Neosart... 205 2e-51
UniRef50_Q9RRY0 Cluster: Porphobilinogen deaminase; n=4; Deinoco... 205 2e-51
UniRef50_Q180R9 Cluster: Porphobilinogen deaminase; n=3; Clostri... 204 2e-51
UniRef50_Q5ZRY6 Cluster: Porphobilinogen deaminase; n=5; Legione... 204 3e-51
UniRef50_Q43316 Cluster: Porphobilinogen deaminase, chloroplast ... 202 1e-50
UniRef50_A6GB01 Cluster: Porphobilinogen deaminase; n=1; Plesioc... 202 1e-50
UniRef50_Q0GL46 Cluster: Porphobilinogen deaminase; n=3; Lactoba... 201 2e-50
UniRef50_Q83A37 Cluster: Porphobilinogen deaminase; n=3; Coxiell... 199 9e-50
UniRef50_A6Q7Y4 Cluster: Porphobilinogen deaminase; n=1; Sulfuro... 198 2e-49
UniRef50_Q2S2A6 Cluster: Porphobilinogen deaminase; n=1; Salinib... 198 2e-49
UniRef50_Q4PFH9 Cluster: Putative uncharacterized protein; n=1; ... 198 3e-49
UniRef50_A3ZKX4 Cluster: Porphobilinogen deaminase; n=1; Blastop... 193 8e-48
UniRef50_Q86ET2 Cluster: Clone ZZD1450 mRNA sequence; n=2; Schis... 193 8e-48
UniRef50_A5ZY88 Cluster: Putative uncharacterized protein; n=3; ... 192 1e-47
UniRef50_Q57B08 Cluster: Porphobilinogen deaminase; n=7; Rhizobi... 192 1e-47
UniRef50_Q92HR5 Cluster: Porphobilinogen deaminase; n=9; Rickett... 192 2e-47
UniRef50_Q5KKQ0 Cluster: Hydroxymethylbilane synthase, putative;... 191 2e-47
UniRef50_Q5XH11 Cluster: LOC495094 protein; n=2; Xenopus|Rep: LO... 190 6e-47
UniRef50_Q11XT5 Cluster: Porphobilinogen deaminase; n=6; Bacteri... 189 1e-46
UniRef50_Q0ATQ1 Cluster: Porphobilinogen deaminase; n=3; Alphapr... 189 1e-46
UniRef50_Q5HBG1 Cluster: Porphobilinogen deaminase; n=2; Ehrlich... 188 2e-46
UniRef50_Q59293 Cluster: Porphobilinogen deaminase; n=5; Clostri... 188 2e-46
UniRef50_A6C1S2 Cluster: Porphobilinogen deaminase; n=1; Plancto... 186 9e-46
UniRef50_Q92LH7 Cluster: Porphobilinogen deaminase; n=53; cellul... 185 2e-45
UniRef50_UPI0000DAE5D1 Cluster: hypothetical protein Rgryl_01000... 184 3e-45
UniRef50_Q0EVH8 Cluster: Porphobilinogen deaminase; n=2; Thermoa... 184 4e-45
UniRef50_Q7M8L2 Cluster: Porphobilinogen deaminase; n=6; Bacteri... 181 3e-44
UniRef50_A5CDH4 Cluster: Porphobilinogen deaminase; n=1; Orienti... 181 3e-44
UniRef50_Q1GP41 Cluster: Porphobilinogen deaminase; n=7; Sphingo... 180 5e-44
UniRef50_A6EES9 Cluster: Porphobilinogen deaminase; n=1; Pedobac... 180 5e-44
UniRef50_Q8RFP5 Cluster: Porphobilinogen deaminase; n=3; Fusobac... 180 6e-44
UniRef50_Q7VFE9 Cluster: Porphobilinogen deaminase; n=19; Epsilo... 179 1e-43
UniRef50_Q5FPS5 Cluster: Porphobilinogen deaminase; n=3; Acetoba... 177 4e-43
UniRef50_Q97MU4 Cluster: Porphobilinogen deaminase; n=12; Clostr... 177 6e-43
UniRef50_Q8TXC8 Cluster: Probable porphobilinogen deaminase; n=2... 175 1e-42
UniRef50_Q57989 Cluster: Probable porphobilinogen deaminase; n=6... 175 1e-42
UniRef50_Q2GJX6 Cluster: Porphobilinogen deaminase; n=11; Ricket... 173 5e-42
UniRef50_Q9F7M2 Cluster: Predicted porphobilinogen deaminase; n=... 173 5e-42
UniRef50_Q8TT56 Cluster: Probable porphobilinogen deaminase; n=6... 173 5e-42
UniRef50_Q0BX92 Cluster: Porphobilinogen deaminase; n=1; Hyphomo... 173 7e-42
UniRef50_O26960 Cluster: Probable porphobilinogen deaminase; n=2... 173 7e-42
UniRef50_A3H5P0 Cluster: Porphobilinogen deaminase; n=1; Caldivi... 173 9e-42
UniRef50_A0LRF1 Cluster: Porphobilinogen deaminase precursor; n=... 172 2e-41
UniRef50_A5KJC5 Cluster: Putative uncharacterized protein; n=1; ... 170 7e-41
UniRef50_A2BL26 Cluster: Probable porphobilinogen deaminase; n=2... 170 7e-41
UniRef50_Q4FNV7 Cluster: Hydroxymethylbilane synthase; n=2; Cand... 169 9e-41
UniRef50_A4CHM3 Cluster: Porphobilinogen deaminase; n=3; Flavoba... 169 2e-40
UniRef50_Q8NT90 Cluster: Porphobilinogen deaminase; n=5; Coryneb... 166 8e-40
UniRef50_Q1AUK3 Cluster: Porphobilinogen deaminase; n=1; Rubroba... 166 1e-39
UniRef50_Q5YP70 Cluster: Porphobilinogen deaminase; n=18; Actino... 165 2e-39
UniRef50_O29026 Cluster: Probable porphobilinogen deaminase; n=1... 164 4e-39
UniRef50_Q82P95 Cluster: Porphobilinogen deaminase 2; n=3; Strep... 164 4e-39
UniRef50_Q7UPN0 Cluster: Porphobilinogen deaminase; n=1; Pirellu... 163 1e-38
UniRef50_Q6L2G8 Cluster: Probable porphobilinogen deaminase; n=2... 162 1e-38
UniRef50_Q2NEP4 Cluster: HemC; n=1; Methanosphaera stadtmanae DS... 161 3e-38
UniRef50_A0RXB2 Cluster: Porphobilinogen deaminase; n=2; Thermop... 160 7e-38
UniRef50_A6LKX0 Cluster: Porphobilinogen deaminase; n=1; Thermos... 159 1e-37
UniRef50_A5CNI4 Cluster: HemC protein; n=2; Actinobacteria (clas... 157 4e-37
UniRef50_Q6AB05 Cluster: Porphobilinogen deaminase; n=17; Actino... 157 7e-37
UniRef50_Q9ABZ8 Cluster: Porphobilinogen deaminase; n=2; Cauloba... 156 9e-37
UniRef50_A4XK06 Cluster: Porphobilinogen deaminase; n=1; Caldice... 154 3e-36
UniRef50_Q8D2W2 Cluster: HemC protein; n=1; Wigglesworthia gloss... 154 5e-36
UniRef50_Q2GE22 Cluster: Putative porphobilinogen deaminase; n=1... 151 2e-35
UniRef50_A4BYX0 Cluster: Porphobilinogen deaminase HemC; n=11; B... 151 4e-35
UniRef50_Q8ZYW7 Cluster: Probable porphobilinogen deaminase; n=3... 149 2e-34
UniRef50_Q5NL83 Cluster: Porphobilinogen deaminase; n=1; Zymomon... 144 4e-33
UniRef50_Q2FTK7 Cluster: Porphobilinogen deaminase; n=1; Methano... 142 1e-32
UniRef50_UPI00015BAF19 Cluster: hydroxymethylbilane synthase; n=... 142 1e-32
UniRef50_Q93A65 Cluster: Porphobilinogen deaminase; n=1; uncultu... 141 3e-32
UniRef50_Q2JFS0 Cluster: Porphobilinogen deaminase; n=2; Frankia... 138 2e-31
UniRef50_UPI000155526F Cluster: PREDICTED: similar to hydroxymet... 137 6e-31
UniRef50_Q3W4S6 Cluster: Porphobilinogen deaminase; n=1; Frankia... 137 6e-31
UniRef50_A4YD92 Cluster: Porphobilinogen deaminase; n=1; Metallo... 134 3e-30
UniRef50_A4YPB9 Cluster: Porphobilinogen deaminase; n=8; Bradyrh... 133 7e-30
UniRef50_Q97B26 Cluster: Probable porphobilinogen deaminase; n=2... 128 2e-28
UniRef50_Q8EY46 Cluster: Porphobilinogen deaminase; n=4; Leptosp... 126 1e-27
UniRef50_Q1EPC8 Cluster: Porphobilinogen deaminase, chloroplast ... 125 2e-27
UniRef50_Q83H95 Cluster: Porphobilinogen deaminase; n=2; Tropher... 123 7e-27
UniRef50_Q9Y9J0 Cluster: Probable porphobilinogen deaminase; n=1... 123 1e-26
UniRef50_Q976H1 Cluster: Probable porphobilinogen deaminase; n=3... 120 5e-26
UniRef50_Q6MHU0 Cluster: Hydroxymethylbilane synthase; n=1; Bdel... 119 2e-25
UniRef50_Q9HMY5 Cluster: Probable porphobilinogen deaminase; n=1... 118 2e-25
UniRef50_Q1XAN5 Cluster: Putative porphobilinogen deaminase; n=2... 116 1e-24
UniRef50_Q9PK95 Cluster: Probable porphobilinogen deaminase; n=7... 113 8e-24
UniRef50_Q7RNI8 Cluster: Porphobilinogen deaminase, putative; n=... 113 1e-23
UniRef50_Q5UY52 Cluster: Porphobilinogen deaminase; n=3; Halobac... 106 9e-22
UniRef50_A7D1I3 Cluster: Porphobilinogen deaminase; n=1; Halorub... 106 9e-22
UniRef50_Q6MEK3 Cluster: Putative Porphobilinogen deaminase; n=1... 104 4e-21
UniRef50_Q6Q923 Cluster: Predicted porphobilinogen deaminase; n=... 96 1e-18
UniRef50_Q1FIV1 Cluster: Porphobilinogen deaminase; n=1; Clostri... 86 1e-15
UniRef50_A5K0J5 Cluster: Porphobilinogen deaminase, putative; n=... 61 6e-08
UniRef50_UPI0000D9FBB5 Cluster: PREDICTED: similar to lethal (3)... 59 2e-07
UniRef50_Q2A077 Cluster: Methyltransferase/helicase protein; n=1... 37 0.83
UniRef50_Q65PS9 Cluster: Lj965 prophage protein; n=2; root|Rep: ... 37 1.1
UniRef50_Q7MQW8 Cluster: Putative uncharacterized protein; n=1; ... 36 1.9
UniRef50_A5FPM5 Cluster: Phospho-2-dehydro-3-deoxyheptonate aldo... 36 1.9
UniRef50_A3M0A2 Cluster: Predicted protein; n=1; Pichia stipitis... 35 3.4
UniRef50_Q1Q6C1 Cluster: Putative uncharacterized protein; n=1; ... 35 4.4
UniRef50_A6GK56 Cluster: Putative uncharacterized protein; n=1; ... 35 4.4
UniRef50_UPI0000F1DC15 Cluster: PREDICTED: hypothetical protein;... 34 5.9
UniRef50_UPI0000D56AE8 Cluster: PREDICTED: similar to CG12950-PA... 34 5.9
UniRef50_Q2IE64 Cluster: Putative uncharacterized protein; n=1; ... 34 5.9
UniRef50_Q6BMT0 Cluster: Similar to tr|Q9C3Y7 Candida albicans L... 34 5.9
UniRef50_Q2S670 Cluster: Methyl-accepting chemotaxis transducer;... 34 7.8
>UniRef50_Q0IEI9 Cluster: Porphobilinogen deaminase; n=4;
Coelomata|Rep: Porphobilinogen deaminase - Aedes aegypti
(Yellowfever mosquito)
Length = 534
Score = 366 bits (901), Expect = e-100
Identities = 187/315 (59%), Positives = 233/315 (73%), Gaps = 3/315 (0%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I VGSRKSELAL+QT VI L++ P+ +++I TMTT+GDRVL++ LPKIGEKSLFTKD
Sbjct: 10 IRVGSRKSELALIQTKHVIACLQKLNPDVQYEIHTMTTVGDRVLNKSLPKIGEKSLFTKD 69
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LEDAL + VDFVVHSLKDLPT+LP G+ IGAV EREDPRDALVLNEKF+ +LSTLP G
Sbjct: 70 LEDALRNGGVDFVVHSLKDLPTSLPIGMAIGAVLEREDPRDALVLNEKFRGKTLSTLPKG 129
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
SVIGTSSLRR+AQL +P L V D+RGNLNTRL KLD E K++ ++LA AGL RMGW
Sbjct: 130 SVIGTSSLRRSAQLARLHPHLVVCDIRGNLNTRLAKLDAEGSKFAGIVLAQAGLVRMGWE 189
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
R+ +V+ SE+LYAVGQGALAVECR+++E +L ML+ H ET C++L ERSFLKTLGG
Sbjct: 190 KRIDQVIEPSEILYAVGQGALAVECRSNDEYILNMLSKLCHLETQCKILVERSFLKTLGG 249
Query: 249 GCSAPVGISTKLKQNDNVYK--LTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPT 306
GCSAPV + T LK+ + L + GAVWSLDG T++ D ++ + +
Sbjct: 250 GCSAPVAVCTSLKRKHDSKSNYLNIQGAVWSLDGKTEIRAD-DGCSVELEHVQQSDIDNG 308
Query: 307 EEASSKKIKTDKTVE 321
+KK KT+ V+
Sbjct: 309 NGVPAKKSKTEDVVD 323
Score = 50.0 bits (114), Expect = 1e-04
Identities = 25/60 (41%), Positives = 36/60 (60%), Gaps = 2/60 (3%)
Query: 346 APNVADR--RCFCGLTTNVNMPIDVVIKCDNLGRDLANSLIDKGALEVMKISHDIIRSSI 403
AP + D FCG+ N N+P + C+ LG+ LA+ LI KGAL+VMK + + I S +
Sbjct: 475 APKLEDNSEHLFCGMHRNKNVPNESFEACEKLGQQLAHFLISKGALDVMKCAQNEIHSKV 534
>UniRef50_Q9W0G4 Cluster: CG9165-PA; n=6; Coelomata|Rep: CG9165-PA -
Drosophila melanogaster (Fruit fly)
Length = 652
Score = 364 bits (895), Expect = 3e-99
Identities = 188/317 (59%), Positives = 234/317 (73%), Gaps = 6/317 (1%)
Query: 1 MDGETKLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIG 60
M + K+ I VGSRKSELAL+QT VI L++ YP+++F+I TM+T GDRVL+ LPKIG
Sbjct: 1 MSAQEKV-IRVGSRKSELALIQTKHVIGRLQKLYPKQKFEIHTMSTFGDRVLNVSLPKIG 59
Query: 61 EKSLFTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEY 120
EKSLFT+DLEDAL + VDFVVHSLKDLPT LP G+ IGAV ERED RDALVL E FK +
Sbjct: 60 EKSLFTRDLEDALRNGGVDFVVHSLKDLPTALPTGMAIGAVLEREDARDALVLRENFKGH 119
Query: 121 SLSTLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASA 180
++++LP GSVIGTSSLRRTAQ+ YP L V D+RGNLNTRL KLD D K+S +ILA A
Sbjct: 120 TIASLPKGSVIGTSSLRRTAQIRRMYPHLTVCDIRGNLNTRLAKLDAADSKFSGIILAQA 179
Query: 181 GLSRMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAER 240
GL RMGW +R+S+VL +++LYAVGQGALAVECRA++++VLAML T CR+LAER
Sbjct: 180 GLVRMGWMSRISQVLEPTDLLYAVGQGALAVECRANDDQVLAMLQKLMCLNTTCRILAER 239
Query: 241 SFLKTLGGGCSAPVGISTKLK-----QNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQI 295
SFLKTLGGGCSAPV + + LK N L+LTGAVWSLDG+ ++ L +
Sbjct: 240 SFLKTLGGGCSAPVAVWSNLKGEPLNGNSQEVGLSLTGAVWSLDGAIEIRNHLACALNEQ 299
Query: 296 RKTVKHKLSPTEEASSK 312
+ + +EA+S+
Sbjct: 300 KLEGDQRKRGAQEATSQ 316
Score = 37.1 bits (82), Expect = 0.83
Identities = 18/49 (36%), Positives = 27/49 (55%)
Query: 355 FCGLTTNVNMPIDVVIKCDNLGRDLANSLIDKGALEVMKISHDIIRSSI 403
FCGL + + K + LG+ LA LI +GAL+VMK++ I +
Sbjct: 601 FCGLYQHACHSRGIYEKANQLGKTLAEDLIKRGALDVMKVAQAEIHGKV 649
>UniRef50_UPI0000D563F8 Cluster: PREDICTED: similar to CG9165-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG9165-PA - Tribolium castaneum
Length = 460
Score = 363 bits (894), Expect = 3e-99
Identities = 185/280 (66%), Positives = 217/280 (77%), Gaps = 2/280 (0%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I VGSRKSELAL+QT VI LK+ +P K+F+IVTM+TLGD+VLD PLPKIGEKSLFTK+
Sbjct: 7 IRVGSRKSELALIQTRHVISLLKKIHPGKDFEIVTMSTLGDKVLDIPLPKIGEKSLFTKE 66
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE AL + VDFVVHSLKDLPT LP G+ IGAV REDPRDALVL + +Y L TLP G
Sbjct: 67 LEAALSTGCVDFVVHSLKDLPTVLPPGMAIGAVLTREDPRDALVLQKDHDKYLLETLPEG 126
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
SVIGTSSLRR AQL YP LKV +RGNLNTRL+KL DE GKY +ILASAGL RMGW
Sbjct: 127 SVIGTSSLRRGAQLARKYPHLKVESIRGNLNTRLKKL-DELGKYQAIILASAGLIRMGWT 185
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
+R+SK+L E+LYAVGQGALAVECR +E+ + +L P +T RV++ERSFLKTLGG
Sbjct: 186 SRISKILDSDELLYAVGQGALAVECRESDEKTIELLKPLYDVQTALRVISERSFLKTLGG 245
Query: 249 GCSAPVGISTKLKQ-NDNVYKLTLTGAVWSLDGSTKLEET 287
GCSAPV +S+ L + DN + L L GAVWSLDG ++ ET
Sbjct: 246 GCSAPVAVSSDLSRLKDNKHTLKLKGAVWSLDGKEEIIET 285
Score = 37.9 bits (84), Expect = 0.48
Identities = 19/53 (35%), Positives = 29/53 (54%)
Query: 350 ADRRCFCGLTTNVNMPIDVVIKCDNLGRDLANSLIDKGALEVMKISHDIIRSS 402
+D CGL + P++ + + +LG LA SL+ KGA EVM + I S+
Sbjct: 406 SDSNTVCGLVPHTETPVETLKQAQDLGVRLAQSLLGKGAGEVMAKAQATIHSA 458
>UniRef50_UPI0000DB6D6A Cluster: PREDICTED: similar to
Porphobilinogen deaminase (Hydroxymethylbilane synthase)
(HMBS) (Pre-uroporphyrinogen synthase) (PBG-D); n=1;
Apis mellifera|Rep: PREDICTED: similar to
Porphobilinogen deaminase (Hydroxymethylbilane synthase)
(HMBS) (Pre-uroporphyrinogen synthase) (PBG-D) - Apis
mellifera
Length = 357
Score = 360 bits (886), Expect = 3e-98
Identities = 177/284 (62%), Positives = 225/284 (79%), Gaps = 4/284 (1%)
Query: 4 ETKLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKS 63
+T+ I VGSRKSELAL QT +VI+ LK +P KEF+I+TM+T GD++LD+ LPKIGEKS
Sbjct: 5 DTRDVIRVGSRKSELALKQTKYVIECLKEYHPTKEFQIITMSTKGDKILDKSLPKIGEKS 64
Query: 64 LFTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLS 123
LFT++LE AL S VDFVVHSLKDLPT+LP+G+ +GA+ +REDPRDA+V+++K+K +LS
Sbjct: 65 LFTEELELALESGRVDFVVHSLKDLPTSLPEGMALGAILKREDPRDAVVMSKKYKNKTLS 124
Query: 124 TLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLS 183
TLP GSVIGTSSLRR+AQL N P LKV ++RGNLNTRLRKLDDE+G ++ +ILA+AGL
Sbjct: 125 TLPEGSVIGTSSLRRSAQLARNMPHLKVENIRGNLNTRLRKLDDENGPFAAIILAAAGLK 184
Query: 184 RMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFL 243
RM W NR+S++L E LYAVGQGAL VECR + ++L++L P ET R + ERSFL
Sbjct: 185 RMNWENRISQLLEPEEALYAVGQGALGVECRETDWKILSLLEPLYDVETTLRCVCERSFL 244
Query: 244 KTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEET 287
KTLGGGCSAPV +S+ LK LT+TGAVWSLDG +++T
Sbjct: 245 KTLGGGCSAPVAVSSTLKNK----ILTVTGAVWSLDGQKFIKDT 284
>UniRef50_P08397 Cluster: Porphobilinogen deaminase; n=50;
Euteleostomi|Rep: Porphobilinogen deaminase - Homo
sapiens (Human)
Length = 361
Score = 315 bits (774), Expect = 1e-84
Identities = 162/326 (49%), Positives = 221/326 (67%), Gaps = 9/326 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I VG+RKS+LA +QT+ V+ +LK +YP +F+I+ M+T GD++LD L KIGEKSLFTK+
Sbjct: 21 IRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKE 80
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE AL VD VVHSLKDLPT LP G IGA+ +RE+P DA+V + KF +L TLP
Sbjct: 81 LEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEK 140
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
SV+GTSSLRR AQL +P L+ +RGNLNTRLRKLD++ ++S +ILA+AGL RMGW
Sbjct: 141 SVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQ-EFSAIILATAGLQRMGWH 199
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
NR+ ++L E +YAVGQGAL VE RA ++++L ++ + PET R +AER+FL+ L G
Sbjct: 200 NRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEG 259
Query: 249 GCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTEE 308
GCS PV + T +K +L LTG VWSLDGS ++ET+ T I +H+ P ++
Sbjct: 260 GCSVPVAVHTAMKDG----QLYLTGGVWSLDGSDSIQETMQAT---IHVPAQHEDGPEDD 312
Query: 309 ASSKKIKTDKTVEADNEIAVLNRRIT 334
I T + + ++A N I+
Sbjct: 313 PQLVGI-TARNIPRGPQLAAQNLGIS 337
>UniRef50_Q8YVU6 Cluster: Porphobilinogen deaminase; n=42;
Bacteria|Rep: Porphobilinogen deaminase - Anabaena sp.
(strain PCC 7120)
Length = 323
Score = 314 bits (770), Expect = 4e-84
Identities = 151/281 (53%), Positives = 209/281 (74%), Gaps = 6/281 (2%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
+I +GSRKS+LALVQT +V + L+ ++P+ F++ TM+T GD++LD L KIG+K LFTK
Sbjct: 11 TIRIGSRKSQLALVQTYWVREQLQNSFPDINFEVHTMSTQGDKILDVALAKIGDKGLFTK 70
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
+LE ++++ +DF VHSLKDLPT LP+GL + A+ ERE+P DALV++E FK+ + TLP+
Sbjct: 71 ELEVGMINEEIDFAVHSLKDLPTNLPEGLALAAITERENPADALVVHENFKDKQIDTLPA 130
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGW 187
G+VIGTSSLRR AQL +P L DVRGNLNTRL KLD G+Y LILA+AGL R+G
Sbjct: 131 GAVIGTSSLRRLAQLRNQFPHLTFKDVRGNLNTRLAKLD--AGEYDGLILAAAGLQRLGM 188
Query: 188 GNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLG 247
G+R+ ++LP L+AVGQGAL +ECRAD+ E++ +L HPET R LAERSFL++L
Sbjct: 189 GDRVHQILPKEISLHAVGQGALGIECRADDAELITVLKAIEHPETRDRCLAERSFLRSLE 248
Query: 248 GGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETL 288
GGC P+G++T++ N+ L LTG V S+DG +++T+
Sbjct: 249 GGCQVPIGVNTEINGNE----LILTGVVASVDGQNLVKDTV 285
>UniRef50_UPI0000583C22 Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 324
Score = 284 bits (696), Expect = 3e-75
Identities = 138/255 (54%), Positives = 180/255 (70%), Gaps = 1/255 (0%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
+ VGSRKSELA++QTN V++ L++ +PE EFKIVTM T+GD + D+PL IGE +LFTK+
Sbjct: 8 VRVGSRKSELAMIQTNHVVEMLQKVHPETEFKIVTMETIGDHIQDKPLASIGESNLFTKE 67
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE AL VD +VHSLKD+P+ LP + IGA+ EREDP DALVL++K S+ T+ G
Sbjct: 68 LEKALALDEVDMLVHSLKDMPSRLPSNMAIGAICEREDPHDALVLHKKLTGISIETMKEG 127
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
SV+GTSS+RR AQL +P L DVRGNLNTRLRKL DE Y L+LA AG+ RMGW
Sbjct: 128 SVLGTSSVRRVAQLKRKFPHLVFKDVRGNLNTRLRKL-DEGQVYDGLVLAVAGMMRMGWE 186
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
+R+S++L Y+V QGAL +E + N + +L NH T R +AER LKTL G
Sbjct: 187 HRISQILKPDICKYSVSQGALGIEIKTKNRRMHELLRQLNHVPTLIRCIAERGLLKTLEG 246
Query: 249 GCSAPVGISTKLKQN 263
GCSAPV + ++L++N
Sbjct: 247 GCSAPVAVHSELEEN 261
>UniRef50_Q7U5C2 Cluster: Porphobilinogen deaminase; n=24;
Bacteria|Rep: Porphobilinogen deaminase - Synechococcus
sp. (strain WH8102)
Length = 317
Score = 277 bits (679), Expect = 4e-73
Identities = 139/278 (50%), Positives = 188/278 (67%), Gaps = 6/278 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
+ + SR+S+LA+VQTN+V L++ +P + M T GD++LD L KIG+K LFTK+
Sbjct: 6 LRIASRRSQLAMVQTNWVKAELEKAHPGLTITVEAMATQGDKILDVALAKIGDKGLFTKE 65
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE ++ + VHSLKDLPT LP+GL++G + EREDP DALV+N K + L TLP G
Sbjct: 66 LEAQMLVGRAEIAVHSLKDLPTNLPEGLMLGCITEREDPADALVVNAKNANHKLDTLPEG 125
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
+V+GTSSLRR AQL +YP L DVRGN+ TRL KLD G Y LILA+AGL R+G+G
Sbjct: 126 AVVGTSSLRRLAQLRHHYPHLSFKDVRGNVITRLEKLD--SGDYDCLILAAAGLERLGFG 183
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
NR+ +++P L+AVGQGAL +EC D EVL ++ H T R LAER+FL+ L G
Sbjct: 184 NRIHQIIPGDISLHAVGQGALGIECVEDKPEVLEIIKVLEHTTTSRRCLAERAFLRELEG 243
Query: 249 GCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEE 286
GC P+G+++++ N +LTLTG V SLDG + +
Sbjct: 244 GCQVPIGVNSQI----NNEELTLTGMVASLDGKRLIRD 277
>UniRef50_Q54P93 Cluster: Porphobilinogen deaminase; n=1;
Dictyostelium discoideum AX4|Rep: Porphobilinogen
deaminase - Dictyostelium discoideum AX4
Length = 325
Score = 255 bits (625), Expect = 1e-66
Identities = 132/281 (46%), Positives = 184/281 (65%), Gaps = 3/281 (1%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDLE 70
+GSRKS+LA++QT +V D ++ P +I TM T GD+VLD L KIG+K LFTK+LE
Sbjct: 12 IGSRKSQLAMLQTEWVRDRIQELNPGIIVEIKTMDTTGDKVLDVSLSKIGDKGLFTKELE 71
Query: 71 DALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKF--KEYSLSTLPSG 128
D +++ +D VHSLKD+PT LPDGL +GA+ +R + DA + N K K LS LP G
Sbjct: 72 DMMLNGTIDLAVHSLKDIPTKLPDGLKLGAITKRYNTSDAFIANAKKHGKNCKLSELPQG 131
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
++IG+SSLRR AQL YP L+ D+RGNLNTR +KL+D+ Y +ILA AGL RM
Sbjct: 132 AMIGSSSLRRVAQLKKAYPHLQFKDIRGNLNTRFKKLEDDSNGYDGMILAVAGLERMELT 191
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
+ +S+++P S LYAVGQG+L +EC+ ++ + ++L P H E+ AERS L+ L G
Sbjct: 192 DHISEIIPDSISLYAVGQGSLGIECKDGDDFIQSILNPLIHRESMYCCEAERSMLRDLEG 251
Query: 249 GCSAPVGISTKL-KQNDNVYKLTLTGAVWSLDGSTKLEETL 288
GC P+G+ TKL Q+ L + V +LDGS +E +
Sbjct: 252 GCHVPIGVVTKLHNQSQPDETLEINAIVLNLDGSKYIESKI 292
>UniRef50_P16616 Cluster: Porphobilinogen deaminase; n=22;
Bacillales|Rep: Porphobilinogen deaminase - Bacillus
subtilis
Length = 313
Score = 250 bits (613), Expect = 4e-65
Identities = 135/282 (47%), Positives = 186/282 (65%), Gaps = 9/282 (3%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
+I VGSR+S+LA+ QT +VI LK P F+I + T GDR++D L K+G K LF K
Sbjct: 3 TIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKGDRIVDVTLSKVGGKGLFVK 62
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
++E AL+++ +D VHS+KD+P LP+GLVIG + EREDPRDAL+ + K LS +
Sbjct: 63 EIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPEREDPRDALISKNRVK---LSEMKK 119
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGW 187
G+VIGTSSLRR+AQL P L + +RGN++TRL+KL+ ED Y +ILA+AGLSRMGW
Sbjct: 120 GAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLETED--YDAIILAAAGLSRMGW 177
Query: 188 -GNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
+ +++ L L AVGQGALA+ECR +EE+LA+ + F T VLAER+FL +
Sbjct: 178 KQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQFTDEYTKRTVLAERAFLNAM 237
Query: 247 GGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETL 288
GGC P+ + L D ++ +TG V S DG +ET+
Sbjct: 238 EGGCQVPIAGYSVLNGQD---EIEMTGLVASPDGKIIFKETV 276
>UniRef50_Q6C097 Cluster: Porphobilinogen deaminase; n=10;
Ascomycota|Rep: Porphobilinogen deaminase - Yarrowia
lipolytica (Candida lipolytica)
Length = 338
Score = 248 bits (607), Expect = 2e-64
Identities = 136/292 (46%), Positives = 189/292 (64%), Gaps = 10/292 (3%)
Query: 2 DGETKL-SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIG 60
D +++L + VG RKS+LALVQT V LK+ +P+ F ++ +TTLGD+V +PL
Sbjct: 11 DDQSELPKVFVGGRKSKLALVQTQHVAAMLKKVHPDYSFPVLGLTTLGDQVQSKPLYSFD 70
Query: 61 EKSLFTKDLEDALMSK-----NVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNE 115
K+L+TK+LE L+ K D +VHSLKD+PT LPDG +GA+ REDPRDALV+
Sbjct: 71 GKALWTKELETLLLEKVPGFDQQDIIVHSLKDMPTVLPDGCELGAILTREDPRDALVMAA 130
Query: 116 KFKEYSLSTLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDL 175
+L+ LP+GSV+GTSS+RR+AQL +YP L VRGN+ TRL KLDD + Y L
Sbjct: 131 GSPYKTLADLPAGSVVGTSSIRRSAQLKKSYPGLVYESVRGNVGTRLSKLDDPETPYKCL 190
Query: 176 ILASAGLSRMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCR 235
ILA+AGL R+ G+R++ L +ML+AVGQGAL +E R +E+ +L E+
Sbjct: 191 ILAAAGLKRLDLGDRITGYLQKPDMLHAVGQGALGLEIRQGDEKTKKILEAIYDKESTLC 250
Query: 236 VLAERSFLKTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEET 287
LAER+ ++TL GGCS P+G+ TK + KLTL V S++G+ +E T
Sbjct: 251 CLAERAVMRTLEGGCSVPIGVETKYENG----KLTLDAIVVSVEGTEFVECT 298
>UniRef50_Q09899 Cluster: Porphobilinogen deaminase; n=1;
Schizosaccharomyces pombe|Rep: Porphobilinogen deaminase
- Schizosaccharomyces pombe (Fission yeast)
Length = 336
Score = 247 bits (605), Expect = 4e-64
Identities = 123/277 (44%), Positives = 187/277 (67%), Gaps = 4/277 (1%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGE---KSL 64
S +G+RKS+LA++Q+ + + L+++YP EF I++ T+GD +L + L + KSL
Sbjct: 6 SFPIGTRKSKLAVIQSEIIREELEKHYPHLEFPIISRDTIGDEILSKALFEFKRQLAKSL 65
Query: 65 FTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLST 124
+T++LE L++ +VHSLKDLP+ +PDG+VI + +R P DA+V +++
Sbjct: 66 WTRELEALLVTNQCRILVHSLKDLPSEMPDGMVIACIPKRSCPLDAIVFKAGSHYKTVAD 125
Query: 125 LPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSR 184
LP GSV+GTSS+RR A L N+P L+ VD+RGN+ TRL KLD D ++ L+LA+AGL R
Sbjct: 126 LPPGSVVGTSSIRRRALLARNFPHLRFVDIRGNVGTRLAKLDAPDSQFDCLVLAAAGLFR 185
Query: 185 MGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLK 244
+G +R++++L + YAVGQGALAVE RAD++E++ ML P H ET LAER+ +K
Sbjct: 186 LGLKDRIAQMLTAPFVYYAVGQGALAVEVRADDKEMIEMLKPLQHQETLYACLAERALMK 245
Query: 245 TLGGGCSAPVGISTK-LKQNDNVYKLTLTGAVWSLDG 280
L GGC+ P+G+ T L +++ Y+++L G V S DG
Sbjct: 246 RLQGGCAIPIGVQTDVLAISNSSYRISLLGTVLSADG 282
>UniRef50_P28789 Cluster: Porphobilinogen deaminase; n=9;
Ascomycota|Rep: Porphobilinogen deaminase -
Saccharomyces cerevisiae (Baker's yeast)
Length = 327
Score = 244 bits (597), Expect = 3e-63
Identities = 122/294 (41%), Positives = 185/294 (62%), Gaps = 6/294 (2%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
++H+G RKS+LA++Q+N V+ ++ YP+ + K+ T+ TLGD++ +PL G K+L+TK
Sbjct: 5 TLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKALWTK 64
Query: 68 DLEDALM----SKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLS 123
+LED L SK +D +VHSLKD+PT LP+G +G + +R DP D LV+ SL
Sbjct: 65 ELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAYKSLD 124
Query: 124 TLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLS 183
LP G ++GTSS+RR+AQL YP LK VRGN+ TRL+KLDD Y +ILASAGL
Sbjct: 125 DLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILASAGLM 184
Query: 184 RMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFL 243
RMG NR+++ M +AVGQGAL +E R + +++ +L L+ER+ +
Sbjct: 185 RMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSERALM 244
Query: 244 KTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRK 297
+TL GGCS P+G+ + K N+ KL L V ++G+ +E+ ++ +++
Sbjct: 245 RTLEGGCSVPIGVES--KYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKE 296
>UniRef50_O94048 Cluster: Porphobilinogen deaminase; n=4;
Ascomycota|Rep: Porphobilinogen deaminase - Candida
albicans (Yeast)
Length = 340
Score = 243 bits (595), Expect = 6e-63
Identities = 124/283 (43%), Positives = 183/283 (64%), Gaps = 9/283 (3%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
+ +G RKS+LA+VQ+ V ++ +P I+ ++TLGD+V QPL G KSL+TK+
Sbjct: 14 VQIGGRKSKLAVVQSEIVKKVIEDTFPNLSCSILALSTLGDKVQTQPLYTFGGKSLWTKE 73
Query: 69 LEDALMSK-----NVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLS 123
LE L+ +D +VHSLKD+PT LP+ +G +F+REDPRDA+V+ + SL
Sbjct: 74 LEILLLDSVDEFPKLDLIVHSLKDMPTNLPEEFELGCIFQREDPRDAIVMKQGSSYKSLK 133
Query: 124 TLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLS 183
LP+G+++GTSS+RR++QL NYP L+ VRGN+ TRL KLD + +Y LILASAGL
Sbjct: 134 DLPAGAIVGTSSIRRSSQLIKNYPHLRFESVRGNIQTRLNKLDQPNNEYCCLILASAGLI 193
Query: 184 RMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFL 243
R+G G+R++ L +M YAVGQGAL +E R ++ + ++L P LAERS +
Sbjct: 194 RLGLGHRITSYL--DDMYYAVGQGALGIEIRKGDDNIKSILKKIEDPIATICCLAERSLM 251
Query: 244 KTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEE 286
+ L GGCS P+G+ + N++ +LTL G + S DG+ +E+
Sbjct: 252 RYLEGGCSVPLGVHS--DYNESKQELTLKGIIVSPDGTVSIED 292
>UniRef50_Q6BM23 Cluster: Porphobilinogen deaminase; n=6;
Saccharomycetales|Rep: Porphobilinogen deaminase -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 361
Score = 243 bits (594), Expect = 8e-63
Identities = 126/284 (44%), Positives = 185/284 (65%), Gaps = 9/284 (3%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
+ +G RKS+LA+VQ+ V + + +PE ++ ++TLGD+V +PL G K+L+TK+
Sbjct: 19 VQIGGRKSKLAVVQSEIVKECIVEKFPELSCSVLALSTLGDKVQSKPLYSFGGKALWTKE 78
Query: 69 LEDALMSK-----NVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLS 123
LE L+ + +D +VHSLKD+PT LP+ +G + RED RDALV+ SL+
Sbjct: 79 LEILLLEQVEEYPRLDLIVHSLKDIPTNLPEEFELGCILNREDARDALVMKSGSSYKSLA 138
Query: 124 TLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLS 183
LP GS++GTSS+RR++QL N+P+L+ VRGNL TRL KLDDE+ + L+LASAGL
Sbjct: 139 DLPDGSLVGTSSVRRSSQLLKNHPKLRFDSVRGNLQTRLNKLDDENSPFECLLLASAGLI 198
Query: 184 RMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNH-PETYCRVLAERSF 242
R+G G+R++ L EM YAVGQGAL +E R +E++L +L P TYC LAERS
Sbjct: 199 RIGLGDRITAHLDAPEMYYAVGQGALGIEIRKGDEKMLQLLKTIEDLPTTYC-CLAERSL 257
Query: 243 LKTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEE 286
++ L GGCS P+G+ + ++ N +L+L + S DG +E+
Sbjct: 258 MRHLEGGCSVPIGVQSHYNESTN--ELSLKAIIVSPDGIHFVED 299
>UniRef50_Q4T5L1 Cluster: Chromosome undetermined SCAF9206, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF9206, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 385
Score = 241 bits (590), Expect = 2e-62
Identities = 161/407 (39%), Positives = 228/407 (56%), Gaps = 49/407 (12%)
Query: 16 SELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDLEDALMS 75
S+LA +QT+ V + LK YP+ +IV M+T GD++LD L KIGEKSLFTK+LE+AL
Sbjct: 1 SQLARIQTDSVAEKLKELYPDVHLEIVAMSTTGDKILDTALSKIGEKSLFTKELENALER 60
Query: 76 KNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSVIGTSS 135
VD VVHSLKDLPT+LP G IGAV +RE+P DA+VL+ K +L LP+ SVIGTSS
Sbjct: 61 NEVDLVVHSLKDLPTSLPPGFTIGAVLKRENPHDAVVLHPKNAGKTLDALPAHSVIGTSS 120
Query: 136 LRRTAQLNGNYPQLKVVDV------------------------RGNLNTRLRKLDDEDGK 171
LRR AQL +P L D+ RGNLNTRL+KLD+++
Sbjct: 121 LRRAAQLKKRFPHLDFKDIVSSERCFLPVQPGHRCFFLSSRSQRGNLNTRLKKLDEKE-D 179
Query: 172 YSDLILASAGLSRMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPE 231
++ +ILA+AGL RMGW NR+S++L + +YAVGQGALAVE RA + ++L M++ + P+
Sbjct: 180 FAAIILAAAGLRRMGWDNRISQILEPEDCMYAVGQGALAVEVRAKDADILEMVSVLHDPD 239
Query: 232 TYCRVLAERSFLKTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQT 291
T R +AER+FLK L T + + + +L A W+L L+E
Sbjct: 240 TVLRCIAERAFLKHLVQ--------HTHTHTHTHTHTRSLAVAHWNL---FCLQEG---- 284
Query: 292 FGQIRKTVKHKLSPTEEASSKKIKTDKTVEADNEIAVLNRRITDKTGDLGCEDLAPNVAD 351
G H T+ S+ T D ++ + T +T D +P+ D
Sbjct: 285 -GCSVPVAVH----TKVKDSQLYLTGAVYSLDGSDSL---KETMQTSVAAPADGSPDEVD 336
Query: 352 RRCFCGLTTNVNMPIDVVIKCDNLGRDLANSLIDKGALEVMKISHDI 398
G+T N +P + + + LG DLA L+ KGA E++ ++ +
Sbjct: 337 ECARVGVTAN-KIPGEAQDRAERLGVDLAKLLLSKGAKEILTVARQL 382
>UniRef50_Q5WEP5 Cluster: Porphobilinogen deaminase; n=2;
Firmicutes|Rep: Porphobilinogen deaminase - Bacillus
clausii (strain KSM-K16)
Length = 311
Score = 239 bits (586), Expect = 7e-62
Identities = 129/279 (46%), Positives = 185/279 (66%), Gaps = 9/279 (3%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I +G+R+S+LAL QTN+VID LK+ EF++ + T GDR+LD L K+G K LF K+
Sbjct: 4 IVIGTRRSKLALTQTNWVIDQLKQLGVPYEFEVKEIVTKGDRILDVTLSKVGGKGLFVKE 63
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
+E AL S +D VHS+KD+P+ L + + A+ EREDPRD LV ++L LP+G
Sbjct: 64 IEAALRSGEIDVAVHSMKDVPSELLEEFTLAAITEREDPRDVLVSE---NGHTLDELPAG 120
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
+++GTSSLRR+AQ+ P ++V +RGN+ TRLRKL +ED +S ++LA+AGL R+G+G
Sbjct: 121 AIVGTSSLRRSAQILHRRPDVQVKWIRGNVETRLRKLKEED--FSAIVLAAAGLKRLGYG 178
Query: 189 -NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLG 247
+ +++ L L A+GQGAL +ECR D+ E +LA +H ET VLAER+FLK +
Sbjct: 179 EDVITEYLDKDVCLPAIGQGALGLECRVDDVETTELLAKLHHEETGKAVLAERAFLKEMN 238
Query: 248 GGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEE 286
GGC P+G + ++ V+ LTG V S DG T L+E
Sbjct: 239 GGCQVPIGGYATVLEDGAVF---LTGLVGSPDGKTILKE 274
>UniRef50_Q2RJ26 Cluster: Porphobilinogen deaminase; n=2;
Clostridia|Rep: Porphobilinogen deaminase - Moorella
thermoacetica (strain ATCC 39073)
Length = 313
Score = 236 bits (578), Expect = 7e-61
Identities = 130/280 (46%), Positives = 180/280 (64%), Gaps = 9/280 (3%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ I VGSR+SELA Q +VI +L++ +P ++VT+ T GD++LD L +IG+K LFT
Sbjct: 2 IEIKVGSRESELARWQARWVIQALEKAWPGLSCRLVTLKTKGDKILDVALARIGDKGLFT 61
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
K+LE AL+ +D VHS+KD+PTTLP+GLVIGA+ REDP D LV E Y+L+TLP
Sbjct: 62 KELELALLDGAIDLAVHSMKDMPTTLPEGLVIGAIGPREDPADVLVSPE---GYTLATLP 118
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
+ +GTSSLRR AQL P L++VD+RGN+ TRL K+ + DG + ++LA+AGL R+
Sbjct: 119 IKARVGTSSLRRKAQLAYARPDLELVDLRGNVPTRLAKM-ERDG-LTAIVLAAAGLKRLN 176
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
G + + +P L AVGQGA+ VE RA + V ++A NHP T V AER++L+ L
Sbjct: 177 HGQVLGEPIPYHICLPAVGQGAIGVEIRAGDRRVAELVAAINHPPTAAAVRAERAYLRAL 236
Query: 247 GGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEE 286
GGC P+ ++ L L G V SLDG L +
Sbjct: 237 EGGCQVPIAALATVEDT----ALVLQGMVASLDGREMLRD 272
>UniRef50_Q5KWK6 Cluster: Porphobilinogen deaminase; n=32;
Bacillales|Rep: Porphobilinogen deaminase - Geobacillus
kaustophilus
Length = 309
Score = 236 bits (577), Expect = 9e-61
Identities = 133/280 (47%), Positives = 179/280 (63%), Gaps = 10/280 (3%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
+I VGSR+S+LAL QT +VI+ LK+ F++ + T GDRVLD L K+G K LF K
Sbjct: 3 NIVVGSRRSKLALTQTKWVINELKQLGAPFTFEVKEIVTKGDRVLDVTLSKVGGKGLFVK 62
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
++E L++ +D VHS+KD+P LP+GLVIGAV RED RD LV LS LP
Sbjct: 63 EIEHELLAGGIDMAVHSMKDMPAVLPEGLVIGAVSRREDARDVLVSK---GNRMLSDLPP 119
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGW 187
GSVIGTSSLRR+AQL P L + +RGN++TRL KL+ E+ Y ++LA+AGL+RMGW
Sbjct: 120 GSVIGTSSLRRSAQLLAYRPDLTIKWIRGNIDTRLAKLESEE--YDAIVLAAAGLARMGW 177
Query: 188 GNR-MSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
G+ +S LP + AVGQGALAVECR D++E+ L+ N +T V AER+FL+ +
Sbjct: 178 GDDVISDYLPFDVCVPAVGQGALAVECREDDDELRQWLSRLNDEQTERAVRAERAFLQQM 237
Query: 247 GGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEE 286
GGC P+ ++K+ + LT V S DG +E
Sbjct: 238 EGGCQVPIAGYAEVKEG----TVRLTALVASPDGKEMYKE 273
>UniRef50_Q75DY0 Cluster: Porphobilinogen deaminase; n=7;
Ascomycota|Rep: Porphobilinogen deaminase - Ashbya
gossypii (Yeast) (Eremothecium gossypii)
Length = 326
Score = 233 bits (570), Expect = 6e-60
Identities = 120/285 (42%), Positives = 183/285 (64%), Gaps = 6/285 (2%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
++ + R+S+LA++Q+ V + ++R +P ++ TLGD+V +PL G K+L+TK
Sbjct: 5 TLRIAGRRSKLAVIQSESVKEIVQREFPNYTCTVLAKQTLGDQVQSKPLYAFGGKALWTK 64
Query: 68 DLEDAL----MSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLS 123
+LED L + + +D +VHSLKD+PT LP+G +GA+ +R DP D LV+ +L
Sbjct: 65 ELEDLLYEEDLDQRIDMIVHSLKDMPTQLPEGFELGAITKRVDPSDCLVMAAGSPYKTLG 124
Query: 124 TLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLS 183
LP+GSV+GTSS+RR+AQL YP L VRGN+ TRL+KLDD + + +ILA+AGL
Sbjct: 125 DLPNGSVVGTSSIRRSAQLRRRYPHLVFASVRGNIQTRLKKLDDPENECKCIILATAGLV 184
Query: 184 RMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFL 243
R+G +R+++ + ML+AVGQGAL +E R +E + A+LA + LAERS +
Sbjct: 185 RLGLESRITQRFDSTIMLHAVGQGALGIETRTGDERLQAILAKVADRNSTICCLAERSLM 244
Query: 244 KTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETL 288
+TL GGCS P+G+ + + ++ LTL G V S+DG+ E T+
Sbjct: 245 RTLEGGCSVPIGVYSTFDEETSM--LTLDGLVVSVDGADAAEATV 287
>UniRef50_Q9KVM1 Cluster: Porphobilinogen deaminase; n=57;
Gammaproteobacteria|Rep: Porphobilinogen deaminase -
Vibrio cholerae
Length = 311
Score = 232 bits (567), Expect = 1e-59
Identities = 121/269 (44%), Positives = 168/269 (62%), Gaps = 6/269 (2%)
Query: 5 TKLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSL 64
T+ I + +R+S LAL Q N+V D+L +P + ++VTM T GD +LD PL K+G K L
Sbjct: 2 TETPIRIATRQSPLALWQANYVKDALMAAHPGLQVELVTMVTRGDVILDTPLAKVGGKGL 61
Query: 65 FTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLST 124
F K+LE A++ D VHS+KD+P PDGL + + EREDPRDA V N K +
Sbjct: 62 FVKELEIAMLEGRADLAVHSMKDVPVDFPDGLGLVTICEREDPRDAFVSNTYAK---IED 118
Query: 125 LPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSR 184
LPSG+++GT SLRR QL P L + ++RGN+ TRL KLD G+Y +ILA+AGL R
Sbjct: 119 LPSGAIVGTCSLRRQCQLKAARPDLVIKELRGNVGTRLSKLD--AGEYDAIILAAAGLKR 176
Query: 185 MGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLK 244
+ +R+ + + L AVGQGA+ +ECR +++ V A+LAP NH +T RV ER+
Sbjct: 177 LELESRIRSFIEPEQSLPAVGQGAVGIECRVNDQRVRALLAPLNHADTADRVRCERAMNL 236
Query: 245 TLGGGCSAPVGISTKLKQNDNVYKLTLTG 273
TL GGC P+G S L + D ++ L G
Sbjct: 237 TLQGGCQVPIG-SYALLEGDTIWLRALVG 264
>UniRef50_P46355 Cluster: Porphobilinogen deaminase; n=144;
Bacteria|Rep: Porphobilinogen deaminase - Yersinia
pestis
Length = 313
Score = 228 bits (558), Expect = 2e-58
Identities = 122/266 (45%), Positives = 163/266 (61%), Gaps = 6/266 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I + +R+S LAL Q ++V L+ N+P + ++V M T GD +LD PL K+G K LF K+
Sbjct: 6 IRIATRQSPLALWQAHYVQHLLQANHPGLQIELVPMVTRGDIILDTPLAKVGGKGLFVKE 65
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE AL+ D VHS+KD+P P+GL + + EREDPRDA V + L LP+G
Sbjct: 66 LELALLDGRADIAVHSMKDVPIAFPEGLGLVTICEREDPRDAFVSSH---YAHLDDLPAG 122
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
SV+GTSSLRR QL P L + D+RGN+ TRL KLD +G Y +ILA AGL R+G
Sbjct: 123 SVVGTSSLRRQCQLRERRPDLIIRDLRGNVGTRLAKLD--NGDYQAIILAVAGLKRLGLE 180
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
NR+ + E L AVGQGA+ +ECR D++ +LAP NH T RV AER+ L G
Sbjct: 181 NRIRYAMSAEESLPAVGQGAVGIECRLDDDHTRQLLAPLNHRHTELRVCAERAMNIRLEG 240
Query: 249 GCSAPVGISTKLKQNDNVYKLTLTGA 274
GC P+G +L + D ++ L GA
Sbjct: 241 GCQVPIGSYAEL-EGDTLWLRALVGA 265
>UniRef50_Q602K3 Cluster: Porphobilinogen deaminase; n=26; cellular
organisms|Rep: Porphobilinogen deaminase - Methylococcus
capsulatus
Length = 322
Score = 228 bits (557), Expect = 2e-58
Identities = 119/274 (43%), Positives = 174/274 (63%), Gaps = 9/274 (3%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
++ + +RKS LAL Q +V L+ +P+ ++V MTT GD++LD PL K+G K LF K
Sbjct: 17 TLRIATRKSPLALWQAEYVASRLRAAHPDLRVELVGMTTRGDKLLDAPLAKVGGKGLFVK 76
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
+LE L+ D VHS+KD+P P+GL + A+ EREDPRDALV + +++ S + LP+
Sbjct: 77 ELEQGLLEGRADIAVHSMKDVPVEFPEGLHLAAILEREDPRDALV-SHRYR--SFAELPA 133
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGW 187
+ IGTSSLRR Q+ P + D+RGN+NTRL KLD G++ ++LASAGL R+G+
Sbjct: 134 DARIGTSSLRRQCQIKCRLPGCSLYDLRGNVNTRLAKLD--AGEFDAIVLASAGLKRLGF 191
Query: 188 GNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLG 247
R+++ L + L A+GQGA+ VECR+ + A+L P +HP T VLAER+ + L
Sbjct: 192 QERIAETLTPEQCLPAIGQGAIGVECRSTDTRTNALLVPLHHPPTAWCVLAERAMNRRLD 251
Query: 248 GGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGS 281
GGC P+ +L+ + L+L G V + DGS
Sbjct: 252 GGCQVPIAGFAQLEGD----TLSLRGLVGNPDGS 281
>UniRef50_Q8XWW3 Cluster: Porphobilinogen deaminase; n=71;
Proteobacteria|Rep: Porphobilinogen deaminase -
Ralstonia solanacearum (Pseudomonas solanacearum)
Length = 334
Score = 226 bits (552), Expect = 9e-58
Identities = 126/281 (44%), Positives = 166/281 (59%), Gaps = 8/281 (2%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDLE 70
+ SR+S LA+ Q +V +L++ YP + I+ MTT GD++LD+ L K+G K LF K+LE
Sbjct: 24 IASRESRLAMWQAEYVRAALQKYYPACDVSILGMTTRGDQILDRSLAKVGGKGLFVKELE 83
Query: 71 DALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSV 130
AL D VHSLKD+P LP G V+ A+ EREDPRDA V N+ L+ LP+G+V
Sbjct: 84 VALAEGRADLAVHSLKDVPMELPPGFVLSAILEREDPRDAFVSND---YADLAALPAGAV 140
Query: 131 IGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNR 190
+GTSSLRR A L +P L + +RGNL+TRL KLD G Y+ +ILA+AGL R+G R
Sbjct: 141 VGTSSLRREASLRARFPHLVIQPLRGNLDTRLSKLD--RGDYAAIILAAAGLKRLGLSER 198
Query: 191 MSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGGC 250
+ V+ L A GQGAL +E R D +V A LAP +H T V AER+ + LGG C
Sbjct: 199 IRAVIAPETSLPAAGQGALGIESRVDRHDVQAWLAPLHHAPTALAVTAERAVSRQLGGSC 258
Query: 251 SAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQT 291
P+ Q + L L V S DG KL + T
Sbjct: 259 QVPL---AAFAQWTDAGALRLRAFVASPDGRRKLAAEAEAT 296
>UniRef50_Q0UDH2 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 397
Score = 225 bits (551), Expect = 1e-57
Identities = 120/257 (46%), Positives = 168/257 (65%), Gaps = 7/257 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGE----KSL 64
+++G+R S LA +Q V +LK +PE+ + I + GDR PL ++ + KSL
Sbjct: 31 VNIGTRNSTLAQIQARAVAAALKSAHPERTYNICPVVVEGDRDKITPLQQLSQGENAKSL 90
Query: 65 FTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFK-EYSLS 123
+T +LE L ++D +VH LKD+PT LPD L +GA+ EREDPRDAL+++ + + +L+
Sbjct: 91 WTGELETMLEKGDLDIIVHCLKDMPTQLPDNLELGAILEREDPRDALLISPRLPGDTTLA 150
Query: 124 TLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLS 183
TLP G+ IGTSS+RR AQL YP L+ D+RGN+ TRL KLD ED YS +ILA+AGL
Sbjct: 151 TLPQGATIGTSSVRRAAQLRRLYPHLQFADLRGNVGTRLGKLDKEDSPYSAIILAAAGLR 210
Query: 184 RMGWGNRMSKVLPCSE--MLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERS 241
RMG +R+++ L + ML+AVGQGALA+E R D+E + A+L T AER+
Sbjct: 211 RMGLESRITQYLDSATGGMLHAVGQGALAIEIRKDDETMKALLNKIACERTTRACSAERA 270
Query: 242 FLKTLGGGCSAPVGIST 258
L+ L GGCS P+GI T
Sbjct: 271 LLRALEGGCSVPIGIET 287
>UniRef50_O66621 Cluster: Porphobilinogen deaminase; n=2; Aquifex
aeolicus|Rep: Porphobilinogen deaminase - Aquifex
aeolicus
Length = 304
Score = 222 bits (543), Expect = 1e-56
Identities = 115/255 (45%), Positives = 172/255 (67%), Gaps = 8/255 (3%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ I +G+RKS+LAL Q N+V D L++++ E ++V +TT GD++ D PL KIG K LF
Sbjct: 1 MKIRIGTRKSKLALWQANYVKDFLEKHWGV-EVELVKITTTGDKITDVPLAKIGGKGLFV 59
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
K++E AL+ ++D VHSLKD+P +P GL +GA+ +RE+P D L+ K Y LP
Sbjct: 60 KEIEKALLEGSIDLAVHSLKDVPMVIPKGLKLGAITKRENPYDVLISRSGKKLYE---LP 116
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
SGSVIGTSSLRR Q+ LKV +RGN++TR+RKL ++G Y +ILA AG+ RMG
Sbjct: 117 SGSVIGTSSLRRQVQIKKRRRDLKVEVLRGNVDTRMRKL--KEGLYDAVILAYAGVKRMG 174
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
+ + +++VL + + AVGQG+LA+E R ++ + ++ P N+ E++ +AER+FL+ L
Sbjct: 175 YESEITEVL--EDFIPAVGQGSLAIEIREGDKRIEELIKPLNNEESFLCAIAERTFLRRL 232
Query: 247 GGGCSAPVGISTKLK 261
GGC PVG K++
Sbjct: 233 EGGCQVPVGAFAKIE 247
>UniRef50_Q2LQU2 Cluster: Porphobilinogen deaminase; n=1; Syntrophus
aciditrophicus SB|Rep: Porphobilinogen deaminase -
Syntrophus aciditrophicus (strain SB)
Length = 306
Score = 221 bits (539), Expect = 4e-56
Identities = 124/289 (42%), Positives = 180/289 (62%), Gaps = 12/289 (4%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDLE 70
+G+R S LAL QT + L+ YPE +IV + T GD D PL KIG K LF K++E
Sbjct: 3 IGTRGSALALTQTRQIAARLQGQYPEMHLEIVVIKTSGDIQKDVPLAKIGGKGLFIKEIE 62
Query: 71 DALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSV 130
+AL++ VD VHS+KDLP LP+GL I AV REDPRD L+ + +E+ LP+G+
Sbjct: 63 EALLAGTVDLAVHSMKDLPAELPEGLQIAAVPRREDPRDVLI-SGICREF--DNLPAGAR 119
Query: 131 IGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNR 190
IGT SLRR+ QL P L++V +RGNL+TR+RK+ +++A+AG+ RMGW +
Sbjct: 120 IGTGSLRRSVQLRDWRPDLEIVPLRGNLDTRIRKV--AQAALDGVVVAAAGIRRMGWAEK 177
Query: 191 MSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGGC 250
+++ +P +ML AVGQG L +E R ++E++ A LA T V AER+FL+ LGGGC
Sbjct: 178 VTQFIPTEKMLPAVGQGVLCLETREEDEDLKAGLAFLEDKRTRREVTAERAFLRRLGGGC 237
Query: 251 SAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTV 299
+ PV + +Q +V LT+ G V SL+ T + + + +G + + V
Sbjct: 238 TLPV--AAFAEQRGDV--LTIRGMVGSLNERTMIRQ---EIYGSVEQAV 279
>UniRef50_Q1Q7D2 Cluster: Strongly similar to hydroxymethylbilane
synthase; n=1; Candidatus Kuenenia stuttgartiensis|Rep:
Strongly similar to hydroxymethylbilane synthase -
Candidatus Kuenenia stuttgartiensis
Length = 319
Score = 219 bits (535), Expect = 1e-55
Identities = 120/279 (43%), Positives = 176/279 (63%), Gaps = 9/279 (3%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I VGSR S+LAL QTN+VI LK+ P EF+I ++T GD++ D PL ++G +FTK+
Sbjct: 10 IIVGSRGSKLALTQTNWVISELKKLNPGVEFEIKKISTSGDKITDVPLSRLGGVGVFTKE 69
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE AL+ + +D VHS KD+PT + + L +GA+ +R DP D L+ K +L LP
Sbjct: 70 LEVALIKEKIDLAVHSAKDIPTEVSEKLTLGAMPKRVDPSDVLI---SAKNVTLERLPGN 126
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
+ IGTSSLRR AQL P ++VD+RGNL+TRL+KL+ +D +I+A AGL R+G+
Sbjct: 127 ARIGTSSLRRKAQLLALRPDFEIVDLRGNLDTRLKKLEADD--LDGIIVAHAGLIRIGYT 184
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
++S+++P ML AVGQG+L +E R D+E + +L+ + T V AER+ L L G
Sbjct: 185 GQISEIIPFEIMLPAVGQGSLGIEIRKDDERINKILSKMDDLHTRIAVEAERALLAKLQG 244
Query: 249 GCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEET 287
GC P+G K+ ND V+ L + +LDG + ++
Sbjct: 245 GCQVPIGAHAKV-LNDEVH---LEAVICTLDGERTIRDS 279
>UniRef50_Q3E1E4 Cluster: Porphobilinogen deaminase; n=3;
Chloroflexi (class)|Rep: Porphobilinogen deaminase -
Chloroflexus aurantiacus J-10-fl
Length = 324
Score = 219 bits (534), Expect = 1e-55
Identities = 126/281 (44%), Positives = 171/281 (60%), Gaps = 15/281 (5%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDLE 70
+G+R S LA VQ+ +V D+L+ +P E ++ ++T GDRVLD L +G+K LF K+LE
Sbjct: 6 LGTRGSALARVQSVWVADALRTAFPSLEVELRIISTTGDRVLDVALSAVGDKGLFVKELE 65
Query: 71 DALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSV 130
AL++ VD VHS KD+PT PDGLV+ A R DPRD LV+ + L+TLP+G+
Sbjct: 66 HALLASEVDLCVHSAKDMPTATPDGLVLAAFPVRVDPRDVLVVRQAGLGTDLATLPAGAR 125
Query: 131 IGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG-W-- 187
+GTSSLRRT+Q+ + P L++ DVRGN++TRLRKL G+Y LILA+AGL R+G W
Sbjct: 126 VGTSSLRRTSQVRHHRPDLQLTDVRGNVDTRLRKL--ASGQYDALILAAAGLRRLGLWDG 183
Query: 188 ------GNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERS 241
G + L S ML AV QG LA+E RAD+E ++ + P LAER+
Sbjct: 184 TPGAQIGEAVVYPLEPSVMLPAVAQGILAIETRADDEATRTLVESLDDPAARAAALAERA 243
Query: 242 FLKTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGST 282
L+ L GGC PV + + L G V +LDGST
Sbjct: 244 LLRRLEGGCQIPVAAHAVMTDTG----MHLRGMVGTLDGST 280
>UniRef50_A1WVT9 Cluster: Porphobilinogen deaminase; n=5;
Gammaproteobacteria|Rep: Porphobilinogen deaminase -
Halorhodospira halophila (strain DSM 244 / SL1)
(Ectothiorhodospirahalophila (strain DSM 244 / SL1))
Length = 310
Score = 217 bits (529), Expect = 6e-55
Identities = 119/275 (43%), Positives = 168/275 (61%), Gaps = 11/275 (4%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
S+ + +R+S+LA+ Q + L+R +P E ++V M+T GD +LDQPL +IG K LF K
Sbjct: 5 SLRIATRRSQLAMWQAEHIAAELQRLHPGLEVELVPMSTRGDEILDQPLARIGGKGLFMK 64
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYS-LSTLP 126
+LED ++ D VHS+KD+P LP+G + AV +R DPRDA V N YS L LP
Sbjct: 65 ELEDGMLRGEADLAVHSMKDIPWRLPEGFDLAAVSDRADPRDAFVSN----HYSDLDELP 120
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
G+ +GT+SLRR Q+ P L++ +RGN+ TRLRKLD DG Y +ILA++GL R+
Sbjct: 121 HGARVGTASLRRQCQIMDRRPDLQIEVLRGNVQTRLRKLD--DGVYDAIILAASGLDRLE 178
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
+R++ L + L AVGQGAL +ECR +E V+ ++ NH T R+ AER L
Sbjct: 179 LTHRIAGRLTPEQSLPAVGQGALGIECREGDERVMKLVEGLNHEATRIRINAERGMNARL 238
Query: 247 GGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGS 281
G C P+G +L D V+ L G V ++DGS
Sbjct: 239 EGSCQVPIGGYAEL-DGDEVH---LRGLVGAIDGS 269
>UniRef50_Q1QEM1 Cluster: Porphobilinogen deaminase; n=2;
Psychrobacter|Rep: Porphobilinogen deaminase -
Psychrobacter cryohalolentis (strain K5)
Length = 345
Score = 215 bits (524), Expect = 2e-54
Identities = 111/257 (43%), Positives = 159/257 (61%), Gaps = 5/257 (1%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
++++ +R+S LAL Q + + L YPE ++ + T GD++LD PL KIG K LF K
Sbjct: 11 TLNIATRQSPLALWQAEHIRNRLLALYPEMTINLLKIVTKGDKILDTPLAKIGGKGLFVK 70
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
+LE AL K D VHSLKD+P LP+GL +G +R P DA V N +S++ LP
Sbjct: 71 ELEQALYDKQADIAVHSLKDVPMDLPEGLTLGVYCKRASPTDAFVSN---TYHSIAELPQ 127
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGW 187
G+V+GT+SLRR Q+ P L++ +RGN+ TRL KLD G+Y +ILA++GL R+
Sbjct: 128 GAVVGTASLRRQCQIKAYRPDLQIKTLRGNVGTRLSKLD--AGEYDAIILATSGLKRIEL 185
Query: 188 GNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLG 247
R+ L + L AVGQGALA+ECR D+ +VL +LAP N + R++AER+ + L
Sbjct: 186 DARIRSELDINICLPAVGQGALAIECREDDADVLKLLAPLNDDKARIRLIAERALNRHLQ 245
Query: 248 GGCSAPVGISTKLKQND 264
GGC P+ L++ D
Sbjct: 246 GGCQVPIAAYAVLQKAD 262
>UniRef50_Q8KCJ4 Cluster: Porphobilinogen deaminase; n=11;
Chlorobiaceae|Rep: Porphobilinogen deaminase -
Chlorobium tepidum
Length = 312
Score = 215 bits (524), Expect = 2e-54
Identities = 119/283 (42%), Positives = 169/283 (59%), Gaps = 9/283 (3%)
Query: 6 KLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLF 65
K + +G+R S LAL Q F L R++PE + + T GD +LD PL KIG+ LF
Sbjct: 2 KKELIIGTRSSPLALWQAEFTKAELSRHFPELNITLKLVKTTGDVLLDSPLSKIGDMGLF 61
Query: 66 TKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTL 125
TKD+E L++K +D VHSLKD+PT P+GLVI + +RED RD +++++ K L L
Sbjct: 62 TKDIEKHLLAKEIDLAVHSLKDVPTGTPEGLVISSFTKREDTRD-VIISKSGK--GLKDL 118
Query: 126 PSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRM 185
P + + TSSLRR +QL P L+++D+RGNLNTR +K D DG++ ++LA AG+ R+
Sbjct: 119 PPNARMATSSLRRMSQLLSMRPDLQILDIRGNLNTRFKKFD--DGEFDAMMLAYAGVYRL 176
Query: 186 GWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKT 245
+ +R+S++LP ML AVGQGAL +E R D+ E + ++ N T AER+ L+
Sbjct: 177 EFSDRISEILPHDVMLPAVGQGALGIETRTDDAETIEIVRVMNDSNTEICCRAERALLRH 236
Query: 246 LGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETL 288
L GGC P+G L L V S+DG T L L
Sbjct: 237 LQGGCQIPIGCYGSYISG----TLKLLAFVGSVDGKTALRNEL 275
>UniRef50_A2Q9P7 Cluster: Catalytic activity: 4
porphobilinogen+H(2)O<=>hydroxymethylbilane+4 NH; n=1;
Aspergillus niger|Rep: Catalytic activity: 4
porphobilinogen+H(2)O<=>hydroxymethylbilane+4 NH -
Aspergillus niger
Length = 346
Score = 213 bits (521), Expect = 5e-54
Identities = 123/292 (42%), Positives = 173/292 (59%), Gaps = 10/292 (3%)
Query: 5 TKLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPL-----PKI 59
T + +G+R S+LALVQ V L +P +F T+ GD P P
Sbjct: 8 TVQELRLGTRNSKLALVQAEHVSKELTSAHPGVQFPWQTVVVRGDADKSSPFLKFAGPSD 67
Query: 60 GEKSLFTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFK- 118
K+++T+++E L + +D +VH LKD+PT LP+ +GA+ REDP DALV+ E +
Sbjct: 68 AAKNIWTEEMETKLCAGELDLLVHCLKDMPTRLPETCTLGAIVYREDPTDALVIKEGLRS 127
Query: 119 EYS-LSTLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLIL 177
+Y+ LS LP GSV+GTSS RR A L YP LKV + RGNL TRL+KLDD +G +S +IL
Sbjct: 128 QYTDLSQLPPGSVVGTSSTRRKALLRYRYPHLKVEECRGNLGTRLKKLDDPEGPFSAIIL 187
Query: 178 ASAGLSRMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVL 237
A+AG+ R+ +R++K LP SE YAVGQGAL +E R ++ + M+ T L
Sbjct: 188 ATAGMVRINLEDRITKRLPPSEFPYAVGQGALGIEIRKEDAQTKTMVRKIEDLVTRRICL 247
Query: 238 AERSFLKTLGGGCSAPVGISTKLKQ---NDNVYKLTLTGAVWSLDGSTKLEE 286
AERS L+TL GGCS+PV + ++Q + +L L G + G+T L E
Sbjct: 248 AERSLLRTLQGGCSSPVAVHCTVEQAPTASSPAQLRLDGTIIHPHGTTLLSE 299
>UniRef50_Q0EWI8 Cluster: Porphobilinogen deaminase; n=2;
Proteobacteria|Rep: Porphobilinogen deaminase -
Mariprofundus ferrooxydans PV-1
Length = 333
Score = 213 bits (520), Expect = 7e-54
Identities = 116/272 (42%), Positives = 162/272 (59%), Gaps = 10/272 (3%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I + +R+S LAL Q ++ L++ P+ ++V + T GD++LD PL K+G K LFTK+
Sbjct: 27 IRIATRRSPLALWQAEYIAAELEKMSPDVTTELVKIVTRGDKILDVPLAKVGGKGLFTKE 86
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
+++AL D VHS+KD+PT LP+G I A+ ER DPRDA L TLP G
Sbjct: 87 IDEALFDGRADVAVHSMKDVPTQLPEGTSIRALPERADPRDAAA---TITGGGLDTLPEG 143
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
+ IGTSSLRR AQL +P K V VRGN+ TRL K+ E +ILA+AG+ RMG
Sbjct: 144 ATIGTSSLRRVAQLQARFPTFKFVSVRGNIQTRLSKMGQE---VDAIILAAAGIRRMGME 200
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
++M + + +L AV QG L ++ R D++ V A++ NH +T R AER+FL L G
Sbjct: 201 DQMHEFIDTEMLLPAVAQGTLGIQTRNDDDVVNALVDRLNHADTVDRTRAERAFLARLEG 260
Query: 249 GCSAPVGISTKLKQNDNVYKLTLTGAVWSLDG 280
GC P+ L + +LTL G V S+DG
Sbjct: 261 GCQVPIAAFATLDGD----QLTLKGLVGSVDG 288
>UniRef50_UPI00006CBE06 Cluster: porphobilinogen deaminase family
protein; n=1; Tetrahymena thermophila SB210|Rep:
porphobilinogen deaminase family protein - Tetrahymena
thermophila SB210
Length = 362
Score = 213 bits (519), Expect = 9e-54
Identities = 126/284 (44%), Positives = 168/284 (59%), Gaps = 18/284 (6%)
Query: 17 ELALVQTNFVIDSLKRNYPEK----EFKI-VT---MTTLGDRVLDQPLPKIGEKSLFTKD 68
EL L + NF + + N P K +FKI +T T GD+ L PL +G +FTK
Sbjct: 47 ELGLTKENFEVVPIS-NAPGKNCTLKFKINITNKQFTNKGDQNLKDPLYVMGGVGVFTKI 105
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
+E L++KN D VHSLKDLPT + + L IGAV + D ++ NEK K L LP G
Sbjct: 106 VEVELLNKNGDIAVHSLKDLPTIIDERLFIGAVPPLKPRGDVVIFNEKHKGKELKDLPEG 165
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
SVIGTSSLRR L YP LK ++RGNLNTRL KL E+G+Y +ILA AG+ R+GW
Sbjct: 166 SVIGTSSLRRITNLKNRYPHLKYENIRGNLNTRLTKL--ENGQYDAIILAEAGVFRLGWI 223
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
++ + L + LYA GQGAL V+CRAD++E +A+L+ N E RV AER FL L G
Sbjct: 224 EKVGQFLKQEDFLYAPGQGALGVQCRADDKEAIALLSYINQKEPRIRVDAERQFLNKLEG 283
Query: 249 ---GCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLD 289
GC P+ + +++ L LTG VWSL+ + E ++
Sbjct: 284 VILGCKLPIAVHSEIIDQ----TLRLTGQVWSLEADKTIREVIE 323
>UniRef50_A3CL78 Cluster: Porphobilinogen deaminase, putative; n=1;
Streptococcus sanguinis SK36|Rep: Porphobilinogen
deaminase, putative - Streptococcus sanguinis (strain
SK36)
Length = 306
Score = 210 bits (512), Expect = 7e-53
Identities = 111/264 (42%), Positives = 168/264 (63%), Gaps = 9/264 (3%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I VG+RKS+LA+ QT ++D LK +PE++F +V TT GDR+ L +IG K +F K+
Sbjct: 4 IKVGTRKSKLAMTQTQQLVDQLKALHPERDFVLVPYTTKGDRLTHVSLQEIGGKGVFVKE 63
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
+E AL++ ++ VHSLKD+P L +G +GA+ +RED RD L+ + + +L+ LP G
Sbjct: 64 IERALLAGEINMAVHSLKDMPAKLAEGCALGAISQREDVRDCLIFRQAGQ--TLADLPKG 121
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
S+IGTSS+RR QL P L +RGN++TR++KL E+G+Y ++LA AGL R+GW
Sbjct: 122 SLIGTSSIRRQVQLQAQRPDLAFKPLRGNIDTRIKKL--EEGEYDAIVLAMAGLKRLGWL 179
Query: 189 NRMS---KVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKT 245
++ + L S L A+ QGALAVECR ++EE+L++LA +T V ER+ L
Sbjct: 180 DQSRLHIQPLETSLCLPAISQGALAVECREEDEELLSLLAAVQDEKTAAEVAVERAVLAQ 239
Query: 246 LGGGCSAPVGISTKLKQNDNVYKL 269
+ C+ P I+ ++N Y+L
Sbjct: 240 MNADCTFP--IAAFAQKNGQGYQL 261
>UniRef50_A0DD68 Cluster: Chromosome undetermined scaffold_46, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_46,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 306
Score = 205 bits (500), Expect = 2e-51
Identities = 116/291 (39%), Positives = 174/291 (59%), Gaps = 14/291 (4%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTT-LGDRVLDQPLPKIGEKSLFTK 67
+ + +R S LA+ QTN+VI LK+ E +I+ ++ +GD L PL ++ +FTK
Sbjct: 5 LRIATRSSALAMAQTNYVISELKQ-----ECEIIKVSNEVGDVNLQDPLYQMPTVGVFTK 59
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
+E L+ + D VHSLKDLPT + L + A + E D ++LN+K+ SLS LP
Sbjct: 60 QVEQYLLEQKADVAVHSLKDLPTIIDAQLHLAAYTKFEQRGDVVLLNKKYNYKSLSELPD 119
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGW 187
G +GTSSLRR A + YP+L ++++RGNLNTR++KLD +G+Y +ILA AG+ R+G
Sbjct: 120 GLKVGTSSLRRIATIRSRYPKLNLINIRGNLNTRIQKLD--EGQYDAIILAKAGILRLGL 177
Query: 188 GNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLG 247
++S L E LYA Q AL ++CR D+ E + L N + R +AER FL L
Sbjct: 178 AEKISFDLDEKEFLYAPAQAALGIQCRKDDLETIGRLQILNDTDAQKRCVAERMFLNLLE 237
Query: 248 GGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLE-ETLD--QTFGQI 295
GGC P+ + ++ +++ VY + G V ++DGS +E E LD + GQI
Sbjct: 238 GGCRLPIAVYSECREDGQVY---IKGRVLAVDGSKVIEDEALDHFEIVGQI 285
>UniRef50_A1DGB8 Cluster: Porphobilinogen deaminase; n=1;
Neosartorya fischeri NRRL 181|Rep: Porphobilinogen
deaminase - Neosartorya fischeri (strain ATCC 1020 / DSM
3700 / NRRL 181)(Aspergillus fischerianus (strain ATCC
1020 / DSM 3700 / NRRL 181))
Length = 363
Score = 205 bits (500), Expect = 2e-51
Identities = 112/259 (43%), Positives = 163/259 (62%), Gaps = 9/259 (3%)
Query: 12 GSRKSELALVQTNFVIDSLKRNY-PEKEFKIVTMTTLGDRVLDQPLPKIGE--------K 62
G RKSELALVQT +V L + P F+I T + +GD P + + K
Sbjct: 26 GCRKSELALVQTRWVTSKLGQTLDPSPTFQIATGSAVGDADKQAPFAVLSKLTGGSDIGK 85
Query: 63 SLFTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSL 122
SL+T +LE L++ V +VHSLKD+PTTLP ++GAV ERED DA+ + K S+
Sbjct: 86 SLWTNELELDLVAGKVHCLVHSLKDMPTTLPPHCLLGAVPEREDCSDAVCMRSDLKFTSI 145
Query: 123 STLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGL 182
LP GS++GTSS RR A + N+P L+VV+ RGN++TRL KLD ++S ++LA+AGL
Sbjct: 146 DQLPPGSIVGTSSSRRKALVRRNWPHLEVVECRGNVDTRLAKLDAPSSRFSCILLATAGL 205
Query: 183 SRMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSF 242
R+G G+R++ L S YAVGQGAL +E D ++L ++ +H + R +AER+
Sbjct: 206 LRLGLGHRITHRLDDSIFPYAVGQGALGLEVSTDRPDILELVRHVDHKPSRWRGIAERAM 265
Query: 243 LKTLGGGCSAPVGISTKLK 261
L++L GGCS+P+G+ + L+
Sbjct: 266 LRSLQGGCSSPIGVQSSLE 284
>UniRef50_Q9RRY0 Cluster: Porphobilinogen deaminase; n=4;
Deinococci|Rep: Porphobilinogen deaminase - Deinococcus
radiodurans
Length = 309
Score = 205 bits (500), Expect = 2e-51
Identities = 120/282 (42%), Positives = 173/282 (61%), Gaps = 10/282 (3%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLD--QPLPKIGEKSLF 65
++ VG+R S LAL QT +V+ LK +PE +F+I T++T GDR + + L + G+K +
Sbjct: 3 TVTVGTRGSTLALAQTRWVVARLKEEWPETDFRIQTISTKGDRNRESLEQLAQKGDKGFW 62
Query: 66 TKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTL 125
K++E+AL++K +D VHSLKDLPT P+GL I ++ +R D RDAL+ E K+ L+ L
Sbjct: 63 VKEIEEALLAKKIDIAVHSLKDLPTEQPEGLEISSIPKRVDGRDALIGREGMKK--LAEL 120
Query: 126 PSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRM 185
P G+ IGTSS+RR A L P L V D+RGN++TRL L G+Y +ILA+AGL R
Sbjct: 121 PEGARIGTSSVRRKAFLRAYRPDLIVKDLRGNIDTRLAALG--SGEYDAIILAAAGLIRT 178
Query: 186 GWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKT 245
+R+ + + +L A GQGALA+E R +++ + + + T R+ AER FL
Sbjct: 179 EQRHRIDEFVDPDILLPAPGQGALALETRTEDDLTIEVAYAIHDHATDDRITAEREFLAG 238
Query: 246 LGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEET 287
LG GC APVG +K LTL G V +LDG+ + T
Sbjct: 239 LGAGCMAPVGAHAVIKNG----LLTLEGWVGALDGTQVIRAT 276
>UniRef50_Q180R9 Cluster: Porphobilinogen deaminase; n=3;
Clostridium|Rep: Porphobilinogen deaminase - Clostridium
difficile (strain 630)
Length = 301
Score = 204 bits (499), Expect = 2e-51
Identities = 110/283 (38%), Positives = 170/283 (60%), Gaps = 8/283 (2%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
++I VG+R S LAL+QT +VI+ LK+ YPE F+I + T GD + + L KIG+K LF
Sbjct: 1 MNIVVGTRGSNLALIQTEWVINELKKKYPEISFEIKIIKTKGDLIQNVSLDKIGDKGLFV 60
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
K++E L+ +D VHS+KD+P+ L +GL +REDPRD L+L E +K +L LP
Sbjct: 61 KEIEQQLLDGKIDIAVHSMKDMPSYLANGLKFAHTPKREDPRDVLILREGYK--NLDDLP 118
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
G+VIGT S RR QL P L +V VRGN+ TR+RK+ DE+ ++LA++G+ R
Sbjct: 119 HGAVIGTGSKRRKFQLLKQRPDLNIVQVRGNVETRIRKIKDEN--MHGIVLAASGIIRAN 176
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
+++S LP ++ A QGALA+E R+++ + ++ T ++LAER FL +
Sbjct: 177 LQDKISSYLPVDVVIPAPAQGALAIEIRSNDSAIEGIVNSLKDENTEIQILAERGFLDGV 236
Query: 247 GGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLD 289
G C P+ ++ Q+ K+ LTG +G + +++D
Sbjct: 237 NGSCHIPMAAYCEIIQD----KIHLTGLYGDSEGKKVVIKSID 275
>UniRef50_Q5ZRY6 Cluster: Porphobilinogen deaminase; n=5; Legionella
pneumophila|Rep: Porphobilinogen deaminase - Legionella
pneumophila subsp. pneumophila (strain Philadelphia 1
/ATCC 33152 / DSM 7513)
Length = 309
Score = 204 bits (498), Expect = 3e-51
Identities = 112/278 (40%), Positives = 166/278 (59%), Gaps = 8/278 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I + +R+S LAL Q N V + L + +P +++ M T GDR L L G K LF K+
Sbjct: 6 IRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKGLFVKE 65
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE+AL+ K D VHS KD+P LPDGL++ A+ +R++P DAL+ + +FK SL+ LP
Sbjct: 66 LEEALLDKRADLAVHSTKDMPAQLPDGLLLTAICKRDNPFDALI-SPQFK--SLAALPKN 122
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
++IGTSSLRR +QL P L++ +RGN++TRL KL E G+Y +ILA+AGL RMG
Sbjct: 123 AIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKL--ESGEYQAIILAAAGLERMGLA 180
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
+ +++++P ML QGAL +ECR D+ E+ ++ N P + V ER LGG
Sbjct: 181 HHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELVHGLNDPISALCVHTERRVNAKLGG 240
Query: 249 GCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEE 286
C P + + + L L V ++DGS +++
Sbjct: 241 NCHIPFAVYCTITEEK---LLLLRAKVLNMDGSQMIDD 275
>UniRef50_Q43316 Cluster: Porphobilinogen deaminase, chloroplast
precursor; n=12; Eukaryota|Rep: Porphobilinogen
deaminase, chloroplast precursor - Arabidopsis thaliana
(Mouse-ear cress)
Length = 382
Score = 202 bits (494), Expect = 1e-50
Identities = 114/283 (40%), Positives = 170/283 (60%), Gaps = 15/283 (5%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEK----EFKIVTMTTLGDRVLDQPLPKIGEKSL 64
I +G+R S LAL Q + LK+ +PE I + T GD++L QPL IG K L
Sbjct: 75 IRIGTRGSPLALAQAYETREKLKKKHPELVEDGAIHIEIIKTTGDKILSQPLADIGGKGL 134
Query: 65 FTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLST 124
FTK++++AL++ ++D VHS+KD+PT LP+ ++ RED RDA + +L+
Sbjct: 135 FTKEIDEALINGHIDIAVHSMKDVPTYLPEKTILPCNLPREDVRDAFIC---LTAATLAE 191
Query: 125 LPSGSVIGTSSLRRTAQLNGNYPQLKVVD-VRGNLNTRLRKLDDEDGKYSDLILASAGLS 183
LP+GSV+GT+SLRR +Q+ YP L V + RGN+ TRL KL + GK +LA AGL
Sbjct: 192 LPAGSVVGTASLRRKSQILHKYPALHVEENFRGNVQTRLSKL--QGGKVQATLLALAGLK 249
Query: 184 RMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFL 243
R+ ++ +L EML AV QGA+ + CR D++++ LA NH ET + ER+FL
Sbjct: 250 RLSMTENVASILSLDEMLPAVAQGAIGIACRTDDDKMATYLASLNHEETRLAISCERAFL 309
Query: 244 KTLGGGCSAPV-GISTKLKQNDNVYKLTLTGAVWSLDGSTKLE 285
+TL G C P+ G ++K ++ + +++ G V S DG+ LE
Sbjct: 310 ETLDGSCRTPIAGYASKDEEGNCIFR----GLVASPDGTKVLE 348
>UniRef50_A6GB01 Cluster: Porphobilinogen deaminase; n=1;
Plesiocystis pacifica SIR-1|Rep: Porphobilinogen
deaminase - Plesiocystis pacifica SIR-1
Length = 322
Score = 202 bits (493), Expect = 1e-50
Identities = 112/276 (40%), Positives = 167/276 (60%), Gaps = 7/276 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEK--EFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ +G+R S LAL Q N + D L + + E ++V + T GDRV D+PL ++G LF
Sbjct: 11 LRLGTRGSALALWQANMIRDRLLAAWGAQGLEVELVRVVTKGDRVTDRPLNQVGGMGLFV 70
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
K LED L++ +DF VHS+KD+P TLP+GL + + ER DPRDA L ++ +L+TLP
Sbjct: 71 KGLEDKLLAGEIDFAVHSMKDMPGTLPEGLTLASTPERADPRDAF-LAAPGRDVTLATLP 129
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
+GS +GTSSLRR A P L++V +RGN+ TR+ K+ +G+ ++LA+AGL R+G
Sbjct: 130 AGSRLGTSSLRRGALAKRINPGLEIVPIRGNVPTRMGKI--AEGEVDAVLLAAAGLDRLG 187
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
G +++ L + A QG LA+E RA + ++ A+ P H T AERS+L TL
Sbjct: 188 KGEAITERLDPDAFMPAACQGVLAIELRAADTDIAALFEPLGHGPTSIVAAAERSYLATL 247
Query: 247 GGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGST 282
GGC P+ +L ++ ++ + G V DGST
Sbjct: 248 QGGCQVPLACHARLSEDGR--RVRVEGLVVEPDGST 281
>UniRef50_Q0GL46 Cluster: Porphobilinogen deaminase; n=3;
Lactobacillus reuteri|Rep: Porphobilinogen deaminase -
Lactobacillus reuteri
Length = 305
Score = 201 bits (491), Expect = 2e-50
Identities = 111/258 (43%), Positives = 156/258 (60%), Gaps = 5/258 (1%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDLE 70
VGSRKS+LA+ QT VI SLK +P +F+I + T GDR L KIG K +F K++E
Sbjct: 7 VGSRKSKLAMAQTKLVIASLKELFPTTQFEIKNVITEGDRNQQASLAKIGGKGVFVKEIE 66
Query: 71 DALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSV 130
+ L + +DF VHSLKD+ LPD L +GA +R P D LV ++F SL LP G+
Sbjct: 67 EELKNCTIDFAVHSLKDVMPVLPDELTLGAFPKRVSPFDCLVSRQEFT--SLDALPHGAR 124
Query: 131 IGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNR 190
IGT+SLRR QL P LK++ +RGN++TRL+K+D E+ + ++LA AGL R+
Sbjct: 125 IGTNSLRRQGQLLNVRPDLKIIPIRGNIDTRLKKIDTEN--LAGVVLAEAGLDRLSIDLS 182
Query: 191 MSKVLPCSEMLY-AVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGG 249
L +++ AVGQG LA+ECR +E V ML N P++ + ER F++ LGG
Sbjct: 183 SYHQLSLKDIIVPAVGQGCLAIECRKADERVRKMLDQINDPQSAKCIHIEREFMRELGGS 242
Query: 250 CSAPVGISTKLKQNDNVY 267
C+ P+G L+ V+
Sbjct: 243 CNFPIGGHAYLQDQQIVF 260
>UniRef50_Q83A37 Cluster: Porphobilinogen deaminase; n=3; Coxiella
burnetii|Rep: Porphobilinogen deaminase - Coxiella
burnetii
Length = 307
Score = 199 bits (486), Expect = 9e-50
Identities = 115/282 (40%), Positives = 164/282 (58%), Gaps = 11/282 (3%)
Query: 6 KLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLF 65
K SI + +RKS LAL Q FV ++ ++P +I+ TT GDR+ + L G K LF
Sbjct: 4 KRSILIVTRKSPLALWQAEFVKQQIENSHPHLACQILGCTTQGDRLTTEKLVDSGGKDLF 63
Query: 66 TKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTL 125
KDL+ AL++++ D VHS+KD+ L++GA REDPRD L++ + LSTL
Sbjct: 64 VKDLQKALLNRDADIAVHSIKDMSACDGPELMVGAFIRREDPRDVLIVKGE-----LSTL 118
Query: 126 PSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRM 185
P +VIGTSS RR QL P K+ ++RGN+ TRL KLD G Y ++LA+AGL R+
Sbjct: 119 PPHAVIGTSSPRRQCQLKKFQPGCKIKEIRGNVGTRLAKLD--AGHYEAIVLAAAGLKRL 176
Query: 186 GWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKT 245
G NR+ E + A+GQGA+ VECR+D+ E+ +L +H ET V AER+ +
Sbjct: 177 GLENRIHYYFDPHEFIPAIGQGAIGVECRSDDHEMQTLLKSLDHRETRLCVTAERAVNEK 236
Query: 246 LGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEET 287
LGG C P+ +K ND +L+L + +DG + T
Sbjct: 237 LGGDCFTPIAAHAIIK-ND---QLSLFAMLGKIDGRVIIRAT 274
>UniRef50_A6Q7Y4 Cluster: Porphobilinogen deaminase; n=1; Sulfurovum
sp. NBC37-1|Rep: Porphobilinogen deaminase - Sulfurovum
sp. (strain NBC37-1)
Length = 323
Score = 198 bits (484), Expect = 2e-49
Identities = 108/280 (38%), Positives = 169/280 (60%), Gaps = 7/280 (2%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDLE 70
+ +R S LAL Q + + ++ +PE ++ +T+ GD++LD+PL +G K FTK+LE
Sbjct: 6 IATRASNLALWQAYHIKERIETAFPEVRVELNEITSKGDKILDKPLALVGGKGHFTKELE 65
Query: 71 DALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSV 130
D +++ N VHSLKD+PT +P+GL + A+ ER+D D + L+ +K SLS LP G+V
Sbjct: 66 DEMIAGNAHLAVHSLKDVPTYIPEGLELCAITERQDQSD-VFLSHTYK--SLSELPEGAV 122
Query: 131 IGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNR 190
+GT+SLRR QL P LKV D+RGN+NTRLRKL ++G+Y +ILA GL R+
Sbjct: 123 VGTTSLRRRMQLLEKRPDLKVKDLRGNVNTRLRKL--KEGQYDAIILAYIGLYRLDLLKD 180
Query: 191 MSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGGC 250
+ V + +GQ AL +E A+N+ + + NH T+ ER F+ +G GC
Sbjct: 181 IPYVEKLDFFIPPMGQAALGIEIVANNDRIREIAMTLNHEPTFICTKVERDFISVIGAGC 240
Query: 251 SAPVGISTKL--KQNDNVYKLTLTGAVWSLDGSTKLEETL 288
SAPV ++ + K++D V +++ + DG+ L ++L
Sbjct: 241 SAPVAVNATMDKKEDDKVPTISVRAMIGYPDGTHILHKSL 280
>UniRef50_Q2S2A6 Cluster: Porphobilinogen deaminase; n=1;
Salinibacter ruber DSM 13855|Rep: Porphobilinogen
deaminase - Salinibacter ruber (strain DSM 13855)
Length = 323
Score = 198 bits (483), Expect = 2e-49
Identities = 115/272 (42%), Positives = 164/272 (60%), Gaps = 10/272 (3%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDLE 70
+G+R SELAL Q N V L+ E + T+TT GD D P+ +IG++++FTK+L+
Sbjct: 9 LGTRGSELALRQANVVRSRLEAAGHRVELE--TITTRGDEATDTPISEIGDEAVFTKELD 66
Query: 71 DALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSV 130
AL+ VD VHSLKD+P+T+P GL + A+ EREDPRDA V + F + L LP G+
Sbjct: 67 RALLQGGVDLAVHSLKDIPSTVPSGLALAAIGEREDPRDAFVAHPSFDGH-LHDLPEGAT 125
Query: 131 IGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNR 190
+ T+SLRRTAQL L+VV VRGN++TRL KL + D ++ ++LA AGL R+G
Sbjct: 126 VATASLRRTAQLLTWRSDLEVVPVRGNVDTRLEKLGESD--WTGMVLAVAGLVRLGLSLH 183
Query: 191 MSKVLPCSEMLYAVGQGALAVECRADNEEVLAML-APFNHPETYCRVLAERSFLKTLGGG 249
+ + S ++ AVGQGAL + CR D + + +L +H + AER+FLK +GGG
Sbjct: 184 IRDRIDPSLIVPAVGQGALGIACREDQDALRDLLRETLHHAPSGHAANAERAFLKKVGGG 243
Query: 250 CSAPVGISTKLKQNDNVYKLTLTGAVWSLDGS 281
C P+G + L L + +LDGS
Sbjct: 244 CQVPLGAWAHIDDG----TLVLDACIAALDGS 271
>UniRef50_Q4PFH9 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 770
Score = 198 bits (482), Expect = 3e-49
Identities = 114/240 (47%), Positives = 144/240 (60%), Gaps = 12/240 (5%)
Query: 39 FKIVTMTTLGDRVLDQPLPKIGE--KSLFTKDLEDALMSKNVDFVVHSLKDLPTTLPDGL 96
F I +M+T GD+ L PL IG K+++TK+LE AL VD +VH LKD+PT LP GL
Sbjct: 251 FPITSMSTAGDQNLRSPLYVIGGEGKAIWTKELEVALEQGAVDAIVHCLKDVPTALPQGL 310
Query: 97 VIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRG 156
+ AV EREDPRDALV+ L LP GSVIGTSS+RR AQL YP L DVRG
Sbjct: 311 ELAAVLEREDPRDALVVKAGLPYKVLDELPVGSVIGTSSVRRVAQLRRRYPHLVFSDVRG 370
Query: 157 NLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNRMSKVLPCSEMLYAVGQGALAVECRAD 216
N+NTRL KLD +G Y+ LILA+AGL R+ R++ L +L++VGQG+LA+E R
Sbjct: 371 NINTRLAKLDAPNGPYTALILAAAGLVRLNMHARITAFLSSPVLLHSVGQGSLAIEVRTP 430
Query: 217 NE----------EVLAMLAPFNHPETYCRVLAERSFLKTLGGGCSAPVGISTKLKQNDNV 266
E + ++ R AERS LK L GGCS PVG+ T+ +D V
Sbjct: 431 PEGADPTTNRDARIRELIRSIGDWRATFRAEAERSLLKELEGGCSIPVGVETRFDDHDQV 490
>UniRef50_A3ZKX4 Cluster: Porphobilinogen deaminase; n=1;
Blastopirellula marina DSM 3645|Rep: Porphobilinogen
deaminase - Blastopirellula marina DSM 3645
Length = 308
Score = 193 bits (470), Expect = 8e-48
Identities = 121/277 (43%), Positives = 163/277 (58%), Gaps = 10/277 (3%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
+I +G+R S+LA Q N+V D L+ + E I+ + T GD V PL IG + +FT
Sbjct: 3 AIRIGTRGSQLAQWQANWVADQLRAVGTDVE--IIHIATQGD-VTQGPLDLIGGRGVFTT 59
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
+++ AL+ +D VHSLKDLPT GL + AV R D L+ + K + LP
Sbjct: 60 EIQAALLDNRIDVAVHSLKDLPTEAVVGLRLAAVPARGADGDVLITS---KASDVLGLPQ 116
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGW 187
S+IGT S+RR AQL ++ D+RGNL+TRLRKLDD G Y +ILA AGL R+
Sbjct: 117 ESIIGTGSMRRKAQLLHLRRDFQIRDIRGNLDTRLRKLDD--GLYDAIILAEAGLRRLEL 174
Query: 188 GNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLG 247
R+ V+P ++ML AVGQGAL +E R + AMLAP NH +++ VLAERS L+ L
Sbjct: 175 IERIRHVIPKAQMLPAVGQGALGLEIRERDSATAAMLAPLNHEDSHYSVLAERSMLRNLR 234
Query: 248 GGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKL 284
GGC APVG ++ + L L G V S DG K+
Sbjct: 235 GGCLAPVGAWGRIDPIKQL--LFLDGVVVSGDGHHKV 269
>UniRef50_Q86ET2 Cluster: Clone ZZD1450 mRNA sequence; n=2;
Schistosoma japonicum|Rep: Clone ZZD1450 mRNA sequence -
Schistosoma japonicum (Blood fluke)
Length = 277
Score = 193 bits (470), Expect = 8e-48
Identities = 102/215 (47%), Positives = 137/215 (63%), Gaps = 14/215 (6%)
Query: 1 MDGETKLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIG 60
+D ++ ++ VGSR+S LAL+QT I LK P F++V + T+GD +LD PL KIG
Sbjct: 2 LDASSQHAVRVGSRRSNLALLQTEMAISLLKVQKPHIMFEVVEIATVGDEILDVPLSKIG 61
Query: 61 EKSLFTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEY 120
+KSLFTK+LE +L+ VD VVHSLKD+P+ LP GLV+G VF R P D +++ +
Sbjct: 62 DKSLFTKELEKSLLVGEVDLVVHSLKDVPSVLPTGLVLGCVFGRSSPEDVVLMAPHNRGM 121
Query: 121 SLSTLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLD------------DE 168
LS LP G+ +GTSS+RR A L YP LK + +RGNLNTRL KLD ++
Sbjct: 122 KLSDLPVGATVGTSSIRRVATLIRKYPHLKFISIRGNLNTRLAKLDTPSNLQKQCCTGNQ 181
Query: 169 DGKYSDLILASAGLSRMGWGNRMSKVLPCSEMLYA 203
Y LILA AG+ RMGW +R+ +VL S+ YA
Sbjct: 182 SLSYDALILAKAGVERMGWVDRIDQVL--SDSFYA 214
>UniRef50_A5ZY88 Cluster: Putative uncharacterized protein; n=3;
Bacteria|Rep: Putative uncharacterized protein -
Ruminococcus obeum ATCC 29174
Length = 312
Score = 192 bits (469), Expect = 1e-47
Identities = 108/249 (43%), Positives = 152/249 (61%), Gaps = 9/249 (3%)
Query: 6 KLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLF 65
K + +GSR+S LA++Q+ V D +K +P + +I+TM T GD++LD+ L K+G K LF
Sbjct: 7 KNKVIIGSRESRLAVLQSEMVRDYIKEQHPGLDVEILTMKTTGDKILDRTLDKVGGKGLF 66
Query: 66 TKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTL 125
K+L+ AL+ VHSLKD+P +P+ L + A REDPRD LVL E ++L
Sbjct: 67 VKELDKALLEGRTMLSVHSLKDMPMEVPEDLPLLAFSRREDPRDVLVLPE-----GAASL 121
Query: 126 PSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRM 185
+G SSLRRT QL YP +KV +RGNL TRLRKLD G+Y+ LILA+AGL R+
Sbjct: 122 DPLKPLGCSSLRRTLQLQTIYPDMKVKSIRGNLQTRLRKLD--AGEYAGLILAAAGLKRL 179
Query: 186 GWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKT 245
G R+ + E+L A GQG LAV+ + L+ + + + AER+F++
Sbjct: 180 GLEKRIHRYFSADEILPAAGQGILAVQGHKGLK--YEYLSGYKDEDAWIAGTAERAFVRY 237
Query: 246 LGGGCSAPV 254
L GGCS+PV
Sbjct: 238 LDGGCSSPV 246
>UniRef50_Q57B08 Cluster: Porphobilinogen deaminase; n=7;
Rhizobiales|Rep: Porphobilinogen deaminase - Brucella
abortus
Length = 314
Score = 192 bits (468), Expect = 1e-47
Identities = 112/285 (39%), Positives = 164/285 (57%), Gaps = 13/285 (4%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNY--PEKEFKIVTMTTLGDRVLDQPLPKIGEKSLF 65
++ +G+R S+LAL Q L+ + PE +I+ M+T GDR+ D+PL ++G K LF
Sbjct: 10 TLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGKGLF 69
Query: 66 TKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTL 125
T+++E AL +D VHS KD+PT LP+GL + EREDPRDA + + L
Sbjct: 70 TEEIEQALKDGRIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARR---FMDL 126
Query: 126 PSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRM 185
P G+ +G+SSLRR A + P ++VV RGN++TRLRKLD G+ LA AGL R+
Sbjct: 127 PQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLD--AGEVDGTFLACAGLRRL 184
Query: 186 GWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKT 245
G + ++ VL S A GQGA+ +E R +E + +LAP H ET + ER+FL
Sbjct: 185 GLADVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERAFLGA 244
Query: 246 LGGGCSAPV-GISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLD 289
L G C P+ G++T + D +L+ G + + DG E T +
Sbjct: 245 LDGSCRTPIAGLAT--VEGD---RLSFRGMILTPDGRQAHEVTAE 284
>UniRef50_Q92HR5 Cluster: Porphobilinogen deaminase; n=9;
Rickettsia|Rep: Porphobilinogen deaminase - Rickettsia
conorii
Length = 351
Score = 192 bits (467), Expect = 2e-47
Identities = 105/248 (42%), Positives = 151/248 (60%), Gaps = 6/248 (2%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
SI +G+RKS LAL+ TN VI +K+ +P+ +IV + T GD + ++PL IG K+LF K
Sbjct: 4 SIRIGTRKSPLALIHTNLVIQQIKQFFPDINCEIVPIITSGDLIQNKPLYDIGGKALFLK 63
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
++E AL+ K +D VHSLKD+P +P+ LVI AV EREDPRD V K S+ LP
Sbjct: 64 EIEQALLDKKIDLAVHSLKDVPGRMPEPLVIAAVLEREDPRDVFVC---LKYKSIEELPQ 120
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGW 187
+VIG+S++RR A + P LKV RGN+++R++KL G+ ILA GL R+
Sbjct: 121 NAVIGSSAVRRKAFIQKIRPDLKVTVFRGNVDSRIKKL--MTGEVDATILAYTGLKRLEV 178
Query: 188 GN-RMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
N ++ S+ML +GQG +AVE R D+ +L + NH T+ + ER+FL+ L
Sbjct: 179 FNPEYCHLIEYSQMLPCIGQGVIAVEIRKDDNAMLEICNQINHLPTFELIKPERAFLEYL 238
Query: 247 GGGCSAPV 254
C P+
Sbjct: 239 DANCRTPI 246
>UniRef50_Q5KKQ0 Cluster: Hydroxymethylbilane synthase, putative;
n=2; Filobasidiella neoformans|Rep: Hydroxymethylbilane
synthase, putative - Cryptococcus neoformans
(Filobasidiella neoformans)
Length = 481
Score = 191 bits (466), Expect = 2e-47
Identities = 104/233 (44%), Positives = 141/233 (60%), Gaps = 7/233 (3%)
Query: 39 FKIVTMTTLGDRVLDQPLPKIGE-------KSLFTKDLEDALMSKNVDFVVHSLKDLPTT 91
F I +MTT+GDR PL + KSL+T +LE L++ + D +VHSLKD+PT
Sbjct: 88 FSIESMTTVGDRNQTTPLHLLSPYSSTQPAKSLWTDELEARLINGHFDMLVHSLKDVPTV 147
Query: 92 LPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSVIGTSSLRRTAQLNGNYPQLKV 151
L DG IG + +R DPRDALV+ + L LP G+V+GT S+RR AQL +P L
Sbjct: 148 LKDGCEIGCMAKRHDPRDALVVKQGLPYKRLEDLPDGAVVGTGSVRRVAQLKRAFPNLVF 207
Query: 152 VDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNRMSKVLPCSEMLYAVGQGALAV 211
D+RGNLNTR KLD+ +S LILA +GL R+G +R + L +++AVGQGALA+
Sbjct: 208 EDMRGNLNTRFNKLDNPQSPFSALILAMSGLERLGMAHRATSPLSSPTLMHAVGQGALAI 267
Query: 212 ECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGGCSAPVGISTKLKQND 264
E R+ + V L H +T AER L+ L GGCS PVG+ ++L + D
Sbjct: 268 EIRSTDPRVRNCLRGLGHWQTEWSCGAERGCLRVLEGGCSVPVGVESELVELD 320
>UniRef50_Q5XH11 Cluster: LOC495094 protein; n=2; Xenopus|Rep:
LOC495094 protein - Xenopus laevis (African clawed frog)
Length = 256
Score = 190 bits (463), Expect = 6e-47
Identities = 95/180 (52%), Positives = 130/180 (72%), Gaps = 5/180 (2%)
Query: 121 SLSTLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASA 180
+LSTLP SVIGTSSLRR AQL +P L+ D+RGNLNTRL+KLD+++ +S ++LA+A
Sbjct: 28 TLSTLPEKSVIGTSSLRRAAQLKKKFPHLEFKDIRGNLNTRLKKLDEQED-FSAIVLAAA 86
Query: 181 GLSRMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAER 240
GL RMGW NR+ ++L E LYAVGQGALAVE R ++++L+M++ PET R +AER
Sbjct: 87 GLRRMGWENRIGQILTSDECLYAVGQGALAVEVRTKDQDILSMVSALQDPETVLRCVAER 146
Query: 241 SFLKTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVK 300
+F+K L GGCS PV +ST +K +L LTGAV+SLDGS L+ET+ +++ V+
Sbjct: 147 AFMKRLEGGCSVPVAVSTVVKD----LQLYLTGAVYSLDGSDSLKETMQSCVNFLQQEVE 202
>UniRef50_Q11XT5 Cluster: Porphobilinogen deaminase; n=6;
Bacteria|Rep: Porphobilinogen deaminase - Cytophaga
hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Length = 312
Score = 189 bits (461), Expect = 1e-46
Identities = 118/283 (41%), Positives = 164/283 (57%), Gaps = 13/283 (4%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
++ +G+R S+LAL Q V L+ E + IV + T GD++LDQ L KIG K LFT+
Sbjct: 4 TVRIGTRGSKLALWQAEHVAACLQTKGLEPQ--IVIIDTTGDKILDQSLSKIGSKGLFTE 61
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
+LE+ L + +D VHS KDL T L G+ I A+ ERE D LV ++ +L P
Sbjct: 62 ELEEQLHAGTIDIAVHSAKDLQTHLKGGMYILAITERELVNDVLVSHKPID--TLKNNPD 119
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGW 187
+IGTSS RR A L YPQ K+VD+RGNL TR+RK+ E+G ++LA AG+ RMG+
Sbjct: 120 -LIIGTSSTRRRALLRKFYPQAKMVDMRGNLQTRIRKM--EEGACDAMLLAYAGMHRMGY 176
Query: 188 GNRMSKVLPCSEMLYAVGQGALAVECRA--DNEEVLAMLAPFNHPETYCRVLAERSFLKT 245
+ + + L E + A GQG LA+E + D E+ + A N T V AER+FL+T
Sbjct: 177 DSLIKEKLSLEEFIPAAGQGTLAIEAASTLDKEKAAVIRAVLNDAATETAVSAERAFLRT 236
Query: 246 LGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETL 288
L GGCS PV + D + LTG + SLDG+ L + +
Sbjct: 237 LEGGCSIPVFALAVERDTDYL----LTGGIVSLDGTKYLRKEI 275
>UniRef50_Q0ATQ1 Cluster: Porphobilinogen deaminase; n=3;
Alphaproteobacteria|Rep: Porphobilinogen deaminase -
Maricaulis maris (strain MCS10)
Length = 321
Score = 189 bits (460), Expect = 1e-46
Identities = 109/250 (43%), Positives = 147/250 (58%), Gaps = 10/250 (4%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNY------PEKEFKIVTMTTLGDRVLDQPLPKIGEKSL 64
+ +R+S LALVQ V L E+ F I+ + + GDR+ D+ L + G K L
Sbjct: 10 IATRRSPLALVQARDVQAKLAAQCGLSGEDAERCFPILGLVSTGDRIQDRTLIEAGGKGL 69
Query: 65 FTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLST 124
FTK++++A + F VHS+KD+PT LPDG+V+GA+ EREDPRD L+ + E L+
Sbjct: 70 FTKEIDEAQLDGRAAFAVHSMKDVPTVLPDGIVLGALLEREDPRDMLIARD--GETRLAD 127
Query: 125 LPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSR 184
LP G IGT+SLRR AQL P L VV +RGN++TRL KL DG LA AGL+R
Sbjct: 128 LPEGVTIGTASLRRQAQLLHKRPDLHVVPLRGNVDTRLGKL--ADGGIHATFLARAGLNR 185
Query: 185 MGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLK 244
+G + L EML A QGA+ V R +EE + +A +H +T VLAER+FL
Sbjct: 186 LGRAEALRDPLEADEMLPAAAQGAVGVAIRDGDEEAASYVAGLHHRDTELAVLAERAFLF 245
Query: 245 TLGGGCSAPV 254
L G C P+
Sbjct: 246 ELDGSCRTPI 255
>UniRef50_Q5HBG1 Cluster: Porphobilinogen deaminase; n=2; Ehrlichia
ruminantium|Rep: Porphobilinogen deaminase - Ehrlichia
ruminantium (strain Welgevonden)
Length = 299
Score = 188 bits (458), Expect = 2e-46
Identities = 104/261 (39%), Positives = 157/261 (60%), Gaps = 5/261 (1%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
++++VG+R S LA+ Q V L +P+ +IV + T GD L +IG K LF
Sbjct: 4 MNVYVGTRGSILAIAQAMEVKKLLYNYFPDINVQIVHIVTSGDINDKISLSEIGGKGLFL 63
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
K+LE+AL++ +D VHS+KD+P D LVI + +R P D + + K SL +LP
Sbjct: 64 KELEEALLTGTIDLAVHSMKDVPAFYCDSLVIPCILKRSSPYDVFISS---KYQSLRSLP 120
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
+VIGTSS+RR QL ++VV +RGN++TR+ KL E G+Y +ILA AGL R+
Sbjct: 121 DNAVIGTSSIRRKVQLMRLLSSVQVVPIRGNVDTRILKL--EAGQYDGIILAKAGLMRIN 178
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
+ + +VL ML AVGQGA+ ++CRA++ +++ M+ N ++Y V AERSF+KT+
Sbjct: 179 KTHVIKEVLDPQVMLSAVGQGAIGIQCRANDYKMIDMIKILNCKKSYISVAAERSFMKTV 238
Query: 247 GGGCSAPVGISTKLKQNDNVY 267
G C P+ K +D +Y
Sbjct: 239 NGSCDTPLAALAKYVNSDTLY 259
>UniRef50_Q59293 Cluster: Porphobilinogen deaminase; n=5;
Clostridium|Rep: Porphobilinogen deaminase - Clostridium
josui
Length = 291
Score = 188 bits (458), Expect = 2e-46
Identities = 99/260 (38%), Positives = 159/260 (61%), Gaps = 12/260 (4%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I +GSR S+LA++Q+ ++ ++++ P+ E +++TM T GD++LD+ L KI K LF K+
Sbjct: 4 IRIGSRDSKLAIIQSELIMSAIRKYDPDIELELITMKTTGDKILDKTLDKIEGKGLFVKE 63
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
L++AL + VD VHS KD+P L + A+ +REDPRDA +L + + +G
Sbjct: 64 LDNALYNNEVDITVHSYKDMPLEENPELPVVALSKREDPRDAFILPQNGE--------NG 115
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
IG+SSLRR QL +P K +RGN+ TRL+KLD G++S ++LA+AG+ R+G
Sbjct: 116 EPIGSSSLRRQLQLKELFPGCKTAPIRGNVQTRLKKLD--SGEFSAIVLAAAGIKRLGLE 173
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
+R+ + E+L A QG +AV+ R E L F+ E+ C LAER+F++ + G
Sbjct: 174 SRIGRYFSVDEILPAASQGIIAVQGRVG--ENFDFLKLFHSEESLCISLAERTFVREMNG 231
Query: 249 GCSAPVGISTKLKQNDNVYK 268
GCS P+ ++ ++ + K
Sbjct: 232 GCSTPIAAYATIQGSEIILK 251
>UniRef50_A6C1S2 Cluster: Porphobilinogen deaminase; n=1;
Planctomyces maris DSM 8797|Rep: Porphobilinogen
deaminase - Planctomyces maris DSM 8797
Length = 318
Score = 186 bits (453), Expect = 9e-46
Identities = 115/281 (40%), Positives = 159/281 (56%), Gaps = 8/281 (2%)
Query: 6 KLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLF 65
K + + +R S LAL Q +V D LK+ E+ +IV +T+ GDR L PL + G +F
Sbjct: 7 KRPLRIATRASNLALWQAYYVSDLLKKQSSERPIEIVHITSEGDRDLTSPLSEFGGLGVF 66
Query: 66 TKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYS-LST 124
T++++ A++ D VHSLKDLPT GL + + ER D L+ + + ++
Sbjct: 67 TREVQKAVLDGRADLAVHSLKDLPTEQAPGLQLAGIPERGPLYDVLIFPQGSEAVEHITD 126
Query: 125 LPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSR 184
L + IGT SLRR AQL L++++VRGN+ TRL+KLD G+Y L LA AG+ R
Sbjct: 127 LADDARIGTGSLRRRAQLLHQRSDLQMLEVRGNVETRLKKLD--AGEYDALCLAEAGMVR 184
Query: 185 MG-WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFL 243
+ R S +L E+ AVGQGAL +ECRAD+EE A+LA + P T AERS L
Sbjct: 185 LELLEQRASLLLQPPEVYPAVGQGALGIECRADDEETAALLAGLSDPPTQAATTAERSLL 244
Query: 244 KTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKL 284
L GC AP+G L Q V +LTL V S DG ++
Sbjct: 245 AHLRAGCHAPIG---SLSQT-TVDQLTLEAVVLSADGVERI 281
>UniRef50_Q92LH7 Cluster: Porphobilinogen deaminase; n=53; cellular
organisms|Rep: Porphobilinogen deaminase - Rhizobium
meliloti (Sinorhizobium meliloti)
Length = 309
Score = 185 bits (451), Expect = 2e-45
Identities = 109/281 (38%), Positives = 161/281 (57%), Gaps = 11/281 (3%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNY--PEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
+G+R S LA+ QT+ D L + P + F+IV ++T GDR+ D+ L +IG K LFT++
Sbjct: 8 IGTRGSPLAMAQTHETRDRLAAAHGLPPEMFEIVILSTKGDRITDRSLAEIGGKGLFTEE 67
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE L+S ++DF VHS KD+PT LP+GL + A RED RDA V + L LP G
Sbjct: 68 LEQQLLSGDLDFAVHSSKDMPTKLPEGLFLSAFLPREDIRDAFVGRSAKR---LVDLPQG 124
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
+ +G+SSLRR A + P + V+ RG + TRLRKL +G+ +LA AGL R+G
Sbjct: 125 ATVGSSSLRRQALIRRLRPDIDVITYRGQVETRLRKL--AEGQVDGTLLAYAGLRRLGME 182
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
+ +++L E A QGA+ VE R ++ + +LA + P T+ V ER FL TL G
Sbjct: 183 HVPTELLDPEEFPPAPAQGAICVEARIGDDRINTLLAAIDDPRTHEAVSCERGFLATLDG 242
Query: 249 GCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLD 289
C P+ Q+D + + G + + DG+T + +D
Sbjct: 243 SCRTPI---AGYAQSDGTH-IRFAGMILTPDGTTSHQIEID 279
>UniRef50_UPI0000DAE5D1 Cluster: hypothetical protein
Rgryl_01000734; n=1; Rickettsiella grylli|Rep:
hypothetical protein Rgryl_01000734 - Rickettsiella
grylli
Length = 311
Score = 184 bits (449), Expect = 3e-45
Identities = 111/280 (39%), Positives = 157/280 (56%), Gaps = 9/280 (3%)
Query: 6 KLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLF 65
K + + +RKS LA Q + + L++ +P + ++ T GDR L + G K LF
Sbjct: 4 KKFLRIATRKSPLAYWQATSIKNQLEKIFPFLKITLLPFVTEGDRP-SHSLNQWGGKGLF 62
Query: 66 TKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTL 125
K+LE AL+ D VHSLKDLP TL GLV+GA+ +R DPRD L+ + + L
Sbjct: 63 VKELEAALLHGQADIAVHSLKDLPMTLEKGLVLGAICKRCDPRDVLISRS---DRLFTQL 119
Query: 126 PSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRM 185
P GS +GTSSLRR +QL P LK+ +RGN+ TRL KL G++ +ILA+AGL R+
Sbjct: 120 PPGSYVGTSSLRRQSQLLALRPDLKIGVLRGNIGTRLNKL--AAGEFDAIILAAAGLIRL 177
Query: 186 GWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKT 245
+S+ L A GQGAL +EC ++EE L ++ HP T+ VLAER+ +
Sbjct: 178 KKTECISEYFEIDHFLPAPGQGALGIECHENDEESLTYISALIHPITHSCVLAERALSRE 237
Query: 246 LGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLE 285
LGGGC P+ D + L V S DG+T+++
Sbjct: 238 LGGGCQVPLAAYAASLGQDFI---RLQAFVGSSDGTTQIK 274
>UniRef50_Q0EVH8 Cluster: Porphobilinogen deaminase; n=2;
Thermoanaerobacter ethanolicus|Rep: Porphobilinogen
deaminase - Thermoanaerobacter ethanolicus X514
Length = 299
Score = 184 bits (448), Expect = 4e-45
Identities = 106/298 (35%), Positives = 168/298 (56%), Gaps = 8/298 (2%)
Query: 6 KLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLF 65
K I VG+R SELAL QT VI+ +K+ + EF+IV +TT GD ++D+P+ +IG K +F
Sbjct: 2 KKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGVF 61
Query: 66 TKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTL 125
K++E AL+ +D VHS+KD+P +P GL + AV +REDP+D V + + L
Sbjct: 62 VKEIESALLKGEIDMAVHSMKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQ---FMDL 118
Query: 126 PSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRM 185
G+ IGTSSLRR QL P +++V +RGN+ TRL+K+ E+ ++L++AGL R+
Sbjct: 119 KEGAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKM--EELNLDGIVLSAAGLHRL 176
Query: 186 GWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPF-NHPETYCRVLAERSFLK 244
G N +++ P ++ A QG LAVE + + P+ +T+ ER LK
Sbjct: 177 GLENIITEYFPPDVVVPAPCQGILAVEIAESFDNIFQEFYPYIVDRKTFFEASVERELLK 236
Query: 245 TLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEET--LDQTFGQIRKTVK 300
G C P G + ++ ++ K+ + A + K E T +++T I K ++
Sbjct: 237 AFGVNCRQPFGAYAQYRKEEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIE 294
>UniRef50_Q7M8L2 Cluster: Porphobilinogen deaminase; n=6;
Bacteria|Rep: Porphobilinogen deaminase - Wolinella
succinogenes
Length = 311
Score = 181 bits (441), Expect = 3e-44
Identities = 106/288 (36%), Positives = 164/288 (56%), Gaps = 12/288 (4%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I +G+R S LAL Q +V L+R + ++ + T GD++LD PL K+G K LFTK+
Sbjct: 4 IIIGTRGSVLALWQAEYVKAELERAHEGLSVELKIVKTKGDKILDVPLAKVGGKGLFTKE 63
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE+ ++ +D VHSLKD+P L +GL + A+ ERED RD L++K+ SL TLP G
Sbjct: 64 LEEMMLQGEIDLAVHSLKDVPVELIEGLTLSAITEREDVRDCF-LSDKYA--SLETLPLG 120
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
+ +GT+SLRR+ Q+ L +RGN+ TR+++L ++G + +ILA+AG++R+
Sbjct: 121 AKVGTTSLRRSMQIKSMRSDLDTESLRGNVQTRIKRL--KEGDFDAIILATAGVNRLDLW 178
Query: 189 NRMSKVLPCSE--MLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
++ V+P M+ A+GQ AL +EC+ + E + + AER F++ L
Sbjct: 179 KEVNYVIPIDTEMMIPAMGQAALGIECK-EGSEAFRLTQILEDKKARIETTAEREFVRVL 237
Query: 247 GGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQ 294
GGC P+G + L+ L L AV DGS L + L G+
Sbjct: 238 EGGCQVPIGANAYLEGE----TLHLKVAVGLPDGSEILMDRLSAPKGE 281
>UniRef50_A5CDH4 Cluster: Porphobilinogen deaminase; n=1; Orientia
tsutsugamushi Boryong|Rep: Porphobilinogen deaminase -
Orientia tsutsugamushi (strain Boryong) (Rickettsia
tsutsugamushi)
Length = 298
Score = 181 bits (440), Expect = 3e-44
Identities = 101/248 (40%), Positives = 148/248 (59%), Gaps = 7/248 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I VGSR S LAL+Q V+ + I+ + T GD + ++ L IG K LF K+
Sbjct: 3 IRVGSRASRLALIQAQAVVQKINDLLGLNAI-IIPIKTTGDLIQNKNLYDIGGKGLFLKE 61
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
+E AL++ +D VHSLKD+P LPDGL + AV ER D D LV K ++ LP G
Sbjct: 62 IEYALLNNTIDIAVHSLKDVPAYLPDGLQLAAVLERGDVGDMLVSKIANK---ITDLPLG 118
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
+++GTSS+RR QL P L +V RGN++TR K+ + + +LA+AGL R+ +
Sbjct: 119 AIVGTSSVRRRIQLLMLRPDLNIVLFRGNVDTRWNKIINNE--VDATVLAAAGLQRLNYD 176
Query: 189 -NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLG 247
+R ++P SEML A+GQGA+A+E R D++ ++ + A NH T+ + ER +LKTL
Sbjct: 177 TSRFCNIIPQSEMLPAIGQGAIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLN 236
Query: 248 GGCSAPVG 255
C+ P+G
Sbjct: 237 ADCNVPIG 244
>UniRef50_Q1GP41 Cluster: Porphobilinogen deaminase; n=7;
Sphingomonadales|Rep: Porphobilinogen deaminase -
Sphingopyxis alaskensis (Sphingomonas alaskensis)
Length = 315
Score = 180 bits (439), Expect = 5e-44
Identities = 112/308 (36%), Positives = 168/308 (54%), Gaps = 8/308 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSL--KRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ +G+R S LA+ Q + +L +IV MT GDR+ D+ L ++G K+L+T
Sbjct: 11 LRIGTRASPLAMAQAHMAAAALIAAHGLAMAALEIVPMTATGDRIQDRALAEVGGKALWT 70
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
++L+ AL + +D VHSLKD+ T +GA+ ER DPRD LV+ E +S LP
Sbjct: 71 RELDAALDAGTIDVAVHSLKDVETLRDARFFLGAMLERADPRDRLVVREGIAAQKISELP 130
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
G+ +GTSS RR AQ+ P L V +RGN+ TRL KL G+ +LA+AGL R+G
Sbjct: 131 HGARLGTSSPRRAAQVRRLRPDLDTVLLRGNVATRLAKL--AAGEADATLLAAAGLERLG 188
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
+ + V +L A QGA+ +ECRAD+ +A+LA +H T+ V AER+ L L
Sbjct: 189 M-HDIGAVQGTELLLPAASQGAIGIECRADDAATIALLAAIDHAPTHRAVAAERALLAVL 247
Query: 247 GGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPT 306
GG C +PV + Q D V L L ++S DG+ + + T + + H+L
Sbjct: 248 GGDCRSPVAAYAEW-QADGV--LRLDAEIFSEDGADHVAGHVIVTDAGVVAALGHRLLAE 304
Query: 307 EEASSKKI 314
S +++
Sbjct: 305 APPSIRRL 312
>UniRef50_A6EES9 Cluster: Porphobilinogen deaminase; n=1; Pedobacter
sp. BAL39|Rep: Porphobilinogen deaminase - Pedobacter
sp. BAL39
Length = 526
Score = 180 bits (439), Expect = 5e-44
Identities = 114/305 (37%), Positives = 170/305 (55%), Gaps = 10/305 (3%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDLE 70
+G+R S+LAL Q NF+ D L E E KI+ T GD++L+ L K+ K FTK+LE
Sbjct: 6 IGTRGSDLALWQANFIKDRLAEIGAEAELKIIK--TQGDKILNLRLDKLEGKGFFTKELE 63
Query: 71 DALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRD-ALVLNEKFKEYSLSTLPSGS 129
+ L+ +D VHS KDLPTT P GL I AV EREDP + L+L + +L +G+
Sbjct: 64 EELLGGTIDIAVHSHKDLPTTHPAGLTIAAVTEREDPSELLLILKDCVDIKQKLSLKTGA 123
Query: 130 VIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG--W 187
++GTSS RR AQL L + D+RGN+ TR++KL DE+ Y ++LA AG++R+
Sbjct: 124 MVGTSSNRRKAQLLALRSDLNIEDLRGNVPTRIQKLRDEN--YDAIVLAKAGVNRLNIDL 181
Query: 188 GNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLG 247
+V+ +E++ A QGALAV+ R ++ E+ A+L NH +T + ER L
Sbjct: 182 SEFHVEVIDPTEIVPAPAQGALAVQIRENDTELFALLQQLNHQDTIDEIAVERKVLNLFE 241
Query: 248 GGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTE 307
GGC P+G K+ + +Y++ + A +L ++ G K V K +P
Sbjct: 242 GGCHMPLG--CYCKKEEGLYEVWTSKAETDEHFPDRLFFRVESLEGLAEKIVA-KFAPER 298
Query: 308 EASSK 312
+ SK
Sbjct: 299 KKPSK 303
>UniRef50_Q8RFP5 Cluster: Porphobilinogen deaminase; n=3;
Fusobacterium nucleatum|Rep: Porphobilinogen deaminase -
Fusobacterium nucleatum subsp. nucleatum
Length = 298
Score = 180 bits (438), Expect = 6e-44
Identities = 103/253 (40%), Positives = 145/253 (57%), Gaps = 10/253 (3%)
Query: 6 KLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPK--IGEKS 63
K +I +GSR S LAL Q N V D L+ NYP F+I + T GD+ L I KS
Sbjct: 2 KKNIIIGSRGSILALAQANLVKDRLQGNYPNLSFEIKEIVTSGDKDLKSNWENSDISLKS 61
Query: 64 LFTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLS 123
FTK++E L+ +D VHS+KD+P L+ GA+ +REDPRD LV K L
Sbjct: 62 FFTKEIEQELLDGEIDIAVHSMKDMPAVSAKSLICGAIPDREDPRDVLV----SKNGLLV 117
Query: 124 TLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLS 183
TLP G+ +GTSSLRR L P ++ +RGN++TRL+KL+ ED Y ++LA+AGL
Sbjct: 118 TLPQGAKVGTSSLRRAMNLKTVRPDFEIKHLRGNIHTRLKKLETED--YDAIVLAAAGLK 175
Query: 184 RMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVL-AERSF 242
R G +++++ L A QG L ++CR ++EE+ +L H E +++ ER F
Sbjct: 176 RTGLADKITEYLNGEVFPPAPAQGVLYIQCRENDEEIKEILKSI-HNEAIAKIVEIEREF 234
Query: 243 LKTLGGGCSAPVG 255
K GGC P+G
Sbjct: 235 SKIFDGGCHTPMG 247
>UniRef50_Q7VFE9 Cluster: Porphobilinogen deaminase; n=19;
Epsilonproteobacteria|Rep: Porphobilinogen deaminase -
Helicobacter hepaticus
Length = 321
Score = 179 bits (436), Expect = 1e-43
Identities = 107/282 (37%), Positives = 165/282 (58%), Gaps = 12/282 (4%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDLE 70
+GSR S LAL Q ++ LK + +I + T GD++LD PL KIG K LFTK+LE
Sbjct: 13 IGSRGSILALWQAEYIKSCLKAQCGLQS-RIQIIKTRGDKILDVPLAKIGGKGLFTKELE 71
Query: 71 DALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSV 130
+ L+SK++D VHSLKD+P L + A+ +RE D L+ + +L+ LP G+
Sbjct: 72 EMLLSKDIDLAVHSLKDVPVEFVPELDLAAITQRESANDCF-LSVNYP--NLNALPQGAK 128
Query: 131 IGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNR 190
+GT+SLRR+ Q+ L + +RGN+ TRL KL +G + +ILA AG++R+ +
Sbjct: 129 VGTTSLRRSMQIKKYRSDLDTLSLRGNVQTRLEKL--HNGAFDAIILAQAGVNRLKINTQ 186
Query: 191 -MSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGG 249
+ ++P M+ A+GQGAL +E R D+ +A N ++ V AER+F++TL GG
Sbjct: 187 DVRYIVPLDFMIPAMGQGALGIEMRKDS-IFFDRIAVLNDKQSALCVSAERAFVRTLEGG 245
Query: 250 CSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQT 291
C P+G+ + N KLTL V DGS L+++++ +
Sbjct: 246 CQVPIGVYAQFSNN----KLTLQAIVGLPDGSEVLQDSVEDS 283
>UniRef50_Q5FPS5 Cluster: Porphobilinogen deaminase; n=3;
Acetobacteraceae|Rep: Porphobilinogen deaminase -
Gluconobacter oxydans (Gluconobacter suboxydans)
Length = 357
Score = 177 bits (431), Expect = 4e-43
Identities = 114/292 (39%), Positives = 159/292 (54%), Gaps = 14/292 (4%)
Query: 6 KLSIHVGSRKSELALVQTNFVIDSLKRNYPEKE----FKIVTMTTLGDRVLDQPLPKIGE 61
KL + VGSR S LALVQT + L R P F+ ++T GDR L Q L +IG
Sbjct: 40 KLPLRVGSRASPLALVQTRNFLTRLTRFCPVLRDMGAFQEYQISTEGDRNLVQRLAEIGG 99
Query: 62 KSLFTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEK----F 117
K LF K++ +AL + +DF VHSLKDL T LP GLV+ +RED RDAL+L ++
Sbjct: 100 KGLFAKEIHEALAAGRIDFAVHSLKDLETNLPPGLVLACTLKREDARDALILRDRDVKVD 159
Query: 118 KEYSLSTLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLIL 177
+ LP G++IG +S+RR AQ+ P L+ +RGN+ TRL KL G +L
Sbjct: 160 PQRPYDCLPEGALIGCASVRRQAQMLHVRPDLRFCLLRGNVQTRLDKL--RAGACEATLL 217
Query: 178 ASAGLSRMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVL 237
A AGL R+G +R+ VL +ML A GQG + V R + E+ +L+ PE
Sbjct: 218 ALAGLRRLGMEDRVDVVLEPDQMLPASGQGIVGVTVRESDLELRELLSAIEDPEARAVST 277
Query: 238 AERSFLKTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLD 289
AER+ L L G C P+G +++ L L+G + S DG+ L ++
Sbjct: 278 AERALLAELDGSCRTPIGGYARIENG----VLKLSGMIASEDGTFLLRREIE 325
>UniRef50_Q97MU4 Cluster: Porphobilinogen deaminase; n=12;
Clostridium|Rep: Porphobilinogen deaminase - Clostridium
acetobutylicum
Length = 291
Score = 177 bits (430), Expect = 6e-43
Identities = 107/251 (42%), Positives = 147/251 (58%), Gaps = 11/251 (4%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ + + +RKS+LA VQT +I+ LK Y K++ M TLGD++LD+ L IG K LF
Sbjct: 1 MKLTIATRKSKLAQVQTELIINVLKDKYGISSEKLL-METLGDKILDKSLADIGGKGLFI 59
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNE--KFKEYSLST 124
KD+E L+ D VHS+KD+P +PD I AV R D RD V + FK+
Sbjct: 60 KDIERILLEDKADAAVHSMKDVPFEVPDMFEIAAVTLRVDVRDVFVSRDGTHFKD----- 114
Query: 125 LPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSR 184
L +G+VIGTSS RR AQL +KVV +RGN+ TR+RK+ +E K +ILA+AGL R
Sbjct: 115 LKNGAVIGTSSNRRAAQLKMLRDDIKVVPIRGNVQTRIRKMGEE--KLDGIILAAAGLKR 172
Query: 185 MGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLK 244
+ N ++ EM+ AVGQGAL VE + +N+ N C V AERSF++
Sbjct: 173 LNMENIITDYFSVEEMIPAVGQGALGVEIKKENKNRDLFRKLDNKNSRMC-VEAERSFMR 231
Query: 245 TLGGGCSAPVG 255
TL G C + +G
Sbjct: 232 TLNGDCHSTIG 242
>UniRef50_Q8TXC8 Cluster: Probable porphobilinogen deaminase; n=2;
Methanopyrus kandleri|Rep: Probable porphobilinogen
deaminase - Methanopyrus kandleri
Length = 298
Score = 175 bits (427), Expect = 1e-42
Identities = 102/275 (37%), Positives = 159/275 (57%), Gaps = 10/275 (3%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYP-EKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+I V +R S LA++QT VI+ L+R P + E +IV + GD V D+PL K+GEK +F
Sbjct: 4 TIRVATRSSRLAIIQTREVIELLERESPRDVEVEIVKTKSRGDVVRDRPLHKLGEKGVFV 63
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
K+++ ++ D VHS KD+P+ + + + AV R DPR+ LV + L LP
Sbjct: 64 KEVDRLVLEGKADIAVHSAKDVPSVVDYPVDVAAVPPRRDPRECLVS----RHGGLKELP 119
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
G+ +GTSS RR AQ+ P LKV +RGN++TR+ K+ + Y +LA GL R+G
Sbjct: 120 RGATVGTSSPRRRAQILLERPDLKVEPMRGNVDTRVSKVRRRE--YDAAVLAKVGLDRLG 177
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
+ +S+V E + GQGAL + CR D++ V +L + ++ V E++ ++ L
Sbjct: 178 MTSEVSEVYDPEEFVPPAGQGALMITCRKDDDRVKRLLEVVDDEKSRVEVETEKAVVREL 237
Query: 247 GGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGS 281
G GCS PVG+ + + D+V +L L ++ DGS
Sbjct: 238 GVGCSEPVGVHVRARDGDHV-RLVL--GLFEEDGS 269
>UniRef50_Q57989 Cluster: Probable porphobilinogen deaminase; n=6;
Methanococcales|Rep: Probable porphobilinogen deaminase
- Methanococcus jannaschii
Length = 292
Score = 175 bits (427), Expect = 1e-42
Identities = 107/261 (40%), Positives = 152/261 (58%), Gaps = 10/261 (3%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I +G+R S+LAL Q N V + LK + E KI+ T GDRVLD+ L IG +FTK+
Sbjct: 2 IRIGTRGSKLALYQANKVAELLKNLGYKVEIKIIKTT--GDRVLDKKLSDIGI-GVFTKE 58
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
L+ A+++ +D VHSLKD+PT + L++GAV ER+ D L+ N K+ + S
Sbjct: 59 LDLAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWN---KDIDFNE-DSK 114
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
VIGTSS+RR A L YP K +RGN++TRLRKL ++G Y ++L+ AG+ R+G
Sbjct: 115 IVIGTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKL--KEGLYDAIVLSEAGIIRLGVS 172
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
++L A QG +AV C+ D+EE+ ++L NH TY L ER+ L GG
Sbjct: 173 LEDFNYKRL-DILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGG 231
Query: 249 GCSAPVGISTKLKQNDNVYKL 269
GCS P G + + + KL
Sbjct: 232 GCSVPFGALAVYDEKNELLKL 252
>UniRef50_Q2GJX6 Cluster: Porphobilinogen deaminase; n=11;
Rickettsiales|Rep: Porphobilinogen deaminase - Anaplasma
phagocytophilum (strain HZ)
Length = 304
Score = 173 bits (422), Expect = 5e-42
Identities = 97/251 (38%), Positives = 147/251 (58%), Gaps = 5/251 (1%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I +G+R S LA+ Q V +++ NY E +I+T+ T GD PL IG K LF K+
Sbjct: 7 IRIGTRGSLLAMQQARIVKTAIETNYAELSTRIITIKTSGDMNTHVPLYDIGGKGLFIKE 66
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
+E+AL+ +D VHS KD+P + L I + R DA L+ K+ S+++LP
Sbjct: 67 IEEALLDNIIDVAVHSAKDVPGIYSEDLDIPCILPRASALDAF-LSSKYD--SIASLPLN 123
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
+ IGTSS+RR QL P L+++ +RGN+ TR+ K+ + G+ ++LA AGL R+
Sbjct: 124 AKIGTSSVRRKVQLLTMRPDLEIIPMRGNVETRISKM--QMGECDGIVLAEAGLYRVSKD 181
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
N +S+VL ML AVGQGA+ V+CR + +L +L N ++Y V AERSF++ + G
Sbjct: 182 NLISEVLQPEVMLGAVGQGAICVQCRRYDRRILEILKKLNCHKSYTTVSAERSFMRAVDG 241
Query: 249 GCSAPVGISTK 259
C+ P+ K
Sbjct: 242 SCNTPLAAMAK 252
>UniRef50_Q9F7M2 Cluster: Predicted porphobilinogen deaminase; n=2;
Bacteria|Rep: Predicted porphobilinogen deaminase -
Gamma-proteobacterium EBAC31A08
Length = 303
Score = 173 bits (422), Expect = 5e-42
Identities = 103/289 (35%), Positives = 160/289 (55%), Gaps = 11/289 (3%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ I + +R+SELA+ Q FV D L + ++V MT+ GD+ D+PL +IG K LF
Sbjct: 1 MKIRIATRQSELAMYQAKFVADELLAKINNIKVELVPMTSEGDQT-DKPLHEIGGKGLFI 59
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
LE +L + D VHSLKD+P L I +VF RE P D L+L++ K S S
Sbjct: 60 STLESSLEADEADIAVHSLKDVPAKLDPKFKIISVFSRESPED-LLLSKDGK--SFSEFA 116
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
S IGTS RR AQ+N P +K + VRGN+ TR++KL+ DG + L++A A + R+G
Sbjct: 117 RNSTIGTSGPRRKAQINNLRPDIKTIPVRGNIATRIKKLN--DGLFDGLVVAKAAIKRLG 174
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
+ S EML + QG +A+EC +D ++++ +L P+ AERSF+ +
Sbjct: 175 L-KQNSYEFSIEEMLPSASQGYIAIECLSDKKDIIELLENIGDPKELILASAERSFVAAM 233
Query: 247 GGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQI 295
G C +P+ I + K ++ ++G + S +G+ K+ + +F I
Sbjct: 234 EGTCLSPIAILCEDKNG----QIKISGKILSYEGNEKIYKEKISSFQDI 278
>UniRef50_Q8TT56 Cluster: Probable porphobilinogen deaminase; n=6;
Euryarchaeota|Rep: Probable porphobilinogen deaminase -
Methanosarcina acetivorans
Length = 317
Score = 173 bits (422), Expect = 5e-42
Identities = 105/271 (38%), Positives = 155/271 (57%), Gaps = 12/271 (4%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKI-GEKSLFTKDL 69
+G+R S+LAL QT V LK E KI+ T GDR D+PL + G F ++L
Sbjct: 3 IGTRGSQLALAQTENVARLLKERGVETSIKIIK--TSGDRFTDRPLHAVSGGVGAFVREL 60
Query: 70 EDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGS 129
+D +++ +D VHS+KD+PT P+GL AV +R+ P D L+ + +L LP +
Sbjct: 61 DDVMLAGEIDIAVHSMKDMPTIRPEGLPTVAVLKRDTPFDILLT---YDGTTLDELPEQA 117
Query: 130 VIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGN 189
+IGTSSLRRTAQ+ P L ++RGN++TRLRKL ++G+Y ++LA AGL RMGW
Sbjct: 118 IIGTSSLRRTAQIRRYRPDLITQELRGNIDTRLRKL--KEGQYDGILLAKAGLERMGW-E 174
Query: 190 RMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGG 249
++L + QG +AV RAD E+ A ++ +H E+ ER + LGGG
Sbjct: 175 IDGEILSPDFFCPSPNQGTVAVVTRAD-PEIEAAVSGLDHTESRIVTEIERILISELGGG 233
Query: 250 CSAPVGISTKLKQNDNVYKLTLTGAVWSLDG 280
C+ P+G +L + ++ + V SLDG
Sbjct: 234 CTTPIGSYAELTSDKQ--EIHIRAEVLSLDG 262
>UniRef50_Q0BX92 Cluster: Porphobilinogen deaminase; n=1; Hyphomonas
neptunium ATCC 15444|Rep: Porphobilinogen deaminase -
Hyphomonas neptunium (strain ATCC 15444)
Length = 321
Score = 173 bits (421), Expect = 7e-42
Identities = 109/277 (39%), Positives = 160/277 (57%), Gaps = 12/277 (4%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKR-NYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
+ +G+R S LAL Q + + D ++ + + +IV TT GD++ + L G K LFT+
Sbjct: 13 LRLGTRGSPLALAQAHQIADGIRAASAGAYDCEIVAFTTTGDKLTTERLINSGGKGLFTR 72
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
+L+DAL +D VHSLKD+P+ LP G + A +REDPRD L+ K S+ LP
Sbjct: 73 ELDDALSRGELDLAVHSLKDVPSVLPPGQIFAAFPKREDPRDGF-LSHGAK--SIQDLPE 129
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGW 187
G+ +GT+SLRR AQ P LKVV RGN+ TR+RKL E+G LA AGL+R+G
Sbjct: 130 GATLGTASLRREAQALALRPDLKVVTFRGNVATRMRKL--EEGLADATFLAMAGLTRLGL 187
Query: 188 GNRMSKVLPCSEMLYAVGQGALAVECRAD-NEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
+ ++ +P +ML A GQG + V R D + E+L +L +H + +AER+FL+ L
Sbjct: 188 -SEVATPIPLEDMLPAAGQGIIGVVTRDDVDTELLEILGQLSHEPSRVAAIAERAFLEKL 246
Query: 247 GGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTK 283
G C P I+ L + ++ L G V S G+T+
Sbjct: 247 DGSCRTP--IAAHLFDRGDEWQ--LIGEVLSPGGTTR 279
>UniRef50_O26960 Cluster: Probable porphobilinogen deaminase; n=2;
Methanobacteriaceae|Rep: Probable porphobilinogen
deaminase - Methanobacterium thermoautotrophicum
Length = 289
Score = 173 bits (421), Expect = 7e-42
Identities = 106/263 (40%), Positives = 152/263 (57%), Gaps = 12/263 (4%)
Query: 12 GSRKSELALVQTNFVIDSLKRNYPEK-EFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDLE 70
G+R S LALVQTN VI+ L EK E KI+ T GDR+ D L + + LFT++L+
Sbjct: 4 GTRGSRLALVQTNHVIEMLSEVCKEKIEKKIIK--TKGDRIRDSQLYSMDSRGLFTRELD 61
Query: 71 DALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSV 130
A++++ VD VHSLKD+P+ L L I AV RE P + LV +++ LP GS
Sbjct: 62 MAVLNEEVDLAVHSLKDVPSDLDPDLAIAAVPPRESPAEVLVSRLDWED-----LPQGSK 116
Query: 131 IGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNR 190
+GTSSLRR A N + K+ +RGN++TR+RK+ DG+ I+A AGL R+G
Sbjct: 117 LGTSSLRREAFCNHHQKNFKMEPLRGNIDTRIRKV--MDGEVHATIMAEAGLKRLGLEEH 174
Query: 191 MSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGGC 250
+ + P A GQGALAV RAD+ E+++ + H + V AE++ L+ LG GC
Sbjct: 175 IKRRFPVEYFTPAAGQGALAVITRADS-ELISSIGRITHHPSLQEVTAEKTLLRELGAGC 233
Query: 251 SAPVGISTKLKQND-NVYKLTLT 272
P+G+ + N +Y + LT
Sbjct: 234 QCPLGVIGRATGNQLTLYAVLLT 256
>UniRef50_A3H5P0 Cluster: Porphobilinogen deaminase; n=1; Caldivirga
maquilingensis IC-167|Rep: Porphobilinogen deaminase -
Caldivirga maquilingensis IC-167
Length = 305
Score = 173 bits (420), Expect = 9e-42
Identities = 100/289 (34%), Positives = 161/289 (55%), Gaps = 8/289 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I + +R S L+L QT V+D + + EFK++ + T GD L +PL +IG K +F ++
Sbjct: 3 IRIATRGSALSLKQTKIVMDRILEFNKDVEFKLIIVKTTGDVDLSKPLYEIGVKGIFERE 62
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
+ A++ D VHSLKD+P + + L + R++PRDALV ++Y++ TLP
Sbjct: 63 VNQAVLRGEADVAVHSLKDMPAQISNDLTLVMTPPRDNPRDALV---SLRQYTVDTLPLN 119
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
S++GTSSLRR L + V +RGN++TR+RKL+ +G+Y LI+A+AGL R+
Sbjct: 120 SIVGTSSLRRRGFLLSLRRDVTVKPIRGNVDTRIRKLN--NGEYDALIMAAAGLERLSIN 177
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
+S++ P M A GQG + V R D ++++ +L + ET+ AER+FL +G
Sbjct: 178 ANVSEISP-ELMPPAPGQGIIGVVARRDRDDLIKVLRRSSDEETFKEAAAERAFLSRIGA 236
Query: 249 GCSAPVGISTKLKQN--DNVYKLTLTGAVWSLDGSTKLEETLDQTFGQI 295
GC P+G L D Y + V ST+++ + G++
Sbjct: 237 GCHVPLGGLALLDDGYFDFTYGVVDPDGVEKFINSTRIDARNPEEAGRV 285
>UniRef50_A0LRF1 Cluster: Porphobilinogen deaminase precursor; n=2;
Actinomycetales|Rep: Porphobilinogen deaminase precursor
- Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Length = 331
Score = 172 bits (418), Expect = 2e-41
Identities = 107/251 (42%), Positives = 145/251 (57%), Gaps = 11/251 (4%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
+ +G+R+S LA QT + +L+ E IV + + GDR D PL + +F +
Sbjct: 10 LRLGTRRSTLARAQTEEIAGALRAAGCRVE--IVGIQSTGDRHADVPLHEFAGSGVFVAE 67
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
L AL+ VD VVHS+KDLPT L I A+ R DPRDALV + L+ LP+G
Sbjct: 68 LRAALLRGEVDVVVHSMKDLPTAEIPELAIAAIPRRADPRDALVTGAGCR---LAELPTG 124
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
+++GT S RR AQL P L++ +RGNL+TRL KL G Y+ LI+A+AGL+R+
Sbjct: 125 AIVGTGSPRRAAQLRLLRPDLEIRPIRGNLDTRLGKL--HAGGYAALIVAAAGLARLHRS 182
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECR----ADNEEVLAMLAPFNHPETYCRVLAERSFLK 244
++ + ML A GQGALAVECR AD + +LA + P T V AER+ L
Sbjct: 183 EEAAEFFDPTVMLPAPGQGALAVECRRADIADGGRLAGILAGLDDPATRAAVTAERALLA 242
Query: 245 TLGGGCSAPVG 255
+G GCSAPVG
Sbjct: 243 AVGAGCSAPVG 253
>UniRef50_A5KJC5 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus torques ATCC 27756|Rep: Putative
uncharacterized protein - Ruminococcus torques ATCC
27756
Length = 307
Score = 170 bits (413), Expect = 7e-41
Identities = 100/273 (36%), Positives = 148/273 (54%), Gaps = 10/273 (3%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I +GSR+S LA+ Q + D ++R +I+TM T GD++LD+ L +G K LF K+
Sbjct: 5 IRIGSRESRLAVKQAEIIKDQIRRCDQTILVEIITMKTTGDKILDRSLESVGGKGLFVKE 64
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLS----T 124
L+ AL +D VHSLKD+P I A REDPRD L+ + KE
Sbjct: 65 LDQALADGRIDLAVHSLKDMPMEESSEFPILAYSRREDPRDVLIYKSEKKEQGTEEGSIL 124
Query: 125 LPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSR 184
+G+VIGTSS RR Q+ YP +RGN+ TRL KL+ E+ Y +LA+AG+ R
Sbjct: 125 TKTGAVIGTSSKRRMIQIQKLYPNAVFQGIRGNIQTRLSKLNKEE--YDAAVLAAAGVKR 182
Query: 185 MGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLK 244
+ + + E++ A GQG LAV+ R + + + ++ + LAERSF++
Sbjct: 183 LNMEAVIGRYFSVDEVIPAAGQGILAVQGRKEFLKDTVWRQYVDDKKSRVQALAERSFIR 242
Query: 245 TLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWS 277
L GGC++P K+K N+ L LTG ++
Sbjct: 243 VLDGGCTSPSAAYAKVKGNE----LELTGLYYN 271
>UniRef50_A2BL26 Cluster: Probable porphobilinogen deaminase; n=2;
Thermoprotei|Rep: Probable porphobilinogen deaminase -
Hyperthermus butylicus (strain DSM 5456 / JCM 9403)
Length = 303
Score = 170 bits (413), Expect = 7e-41
Identities = 101/279 (36%), Positives = 155/279 (55%), Gaps = 8/279 (2%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ + V +R S+L++ QT ++++KR P E+++V + T GD D+P IG K LF
Sbjct: 1 MKLRVATRGSKLSIAQTMIALEAIKRVEPSLEYELVIVKTRGDIHQDKPFTAIGGKGLFE 60
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
K++ A++ D VHSLKD+P+ + GLV+ R+ P D LV+ KE ++ LP
Sbjct: 61 KEVNLAVLEGRADIAVHSLKDVPSAISPGLVLAMTPPRDPPYDVLVVRGG-KEKTIWDLP 119
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
SG+++GTSS RR A L L +RGN++TRLRKL E G+Y ++LA AGL R+G
Sbjct: 120 SGAIVGTSSARRVAMLKHVRRDLVFKVLRGNVDTRLRKL--EQGQYDAIVLAEAGLKRLG 177
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
++ P + A GQG + V + ++L +L + + AER+FL
Sbjct: 178 VDIEYWRI-PPDILPPAPGQGIIGVYTLSSRSDILPILEKASDQKAMAEARAERAFLAYA 236
Query: 247 GGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLE 285
GGGC P+G +L+ N L A+ S DGS ++E
Sbjct: 237 GGGCHTPLGAYAELRGN----TLYFHAALASPDGSRRVE 271
>UniRef50_Q4FNV7 Cluster: Hydroxymethylbilane synthase; n=2;
Candidatus Pelagibacter ubique|Rep: Hydroxymethylbilane
synthase - Pelagibacter ubique
Length = 307
Score = 169 bits (412), Expect = 9e-41
Identities = 97/278 (34%), Positives = 156/278 (56%), Gaps = 12/278 (4%)
Query: 9 IHVGSRKSELALVQTNFVIDSL---KRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLF 65
I +GSR S+LAL+ + + +++ +E I + T GD+V D+ L ++G K LF
Sbjct: 6 IIIGSRGSKLALIYAEKAREKILKHSKDFGIEEVIIKEIVTKGDQVQDKRLSEVGGKGLF 65
Query: 66 TKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTL 125
+K +E L+ K +D VH+LKD+P+ GL+ ER DPR+ L+ + L L
Sbjct: 66 SKTIEVELLEKKIDIAVHALKDMPSEETRGLLTDCFLERNDPREILISKDN---KHLKDL 122
Query: 126 PSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRM 185
S S+IGTSS RR Q+ L +RGN++TR+RKL ++ Y +IL+ AG+ +
Sbjct: 123 ASNSIIGTSSYRREFQIKKIRDDLNCKLIRGNVDTRIRKL--KENLYDAIILSYAGIDSL 180
Query: 186 GWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKT 245
G +S+ SE++ GQG +A++CR ++E ++ +L +H T+ + AER+ LK
Sbjct: 181 GLNQNISQTFSTSEIIPCAGQGVIALQCRDNDESLIELLKQVDHQSTHSSIKAERNVLKV 240
Query: 246 LGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTK 283
L G C VG ++ N K+ L ++SLDGS +
Sbjct: 241 LEGDCETAVGAFANIEGN----KINLEVELFSLDGSKR 274
>UniRef50_A4CHM3 Cluster: Porphobilinogen deaminase; n=3;
Flavobacteriaceae|Rep: Porphobilinogen deaminase -
Robiginitalea biformata HTCC2501
Length = 315
Score = 169 bits (410), Expect = 2e-40
Identities = 108/280 (38%), Positives = 148/280 (52%), Gaps = 16/280 (5%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
++ +G+R SELAL Q V D L+ E +V + + GD VLD+PL ++G +FTK
Sbjct: 4 ALRIGTRDSELALWQAQTVRDRLEAAGHRAE--LVPVKSTGDLVLDKPLYELGITGIFTK 61
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
L+ AL+ +++D VHS+KD+PT LP+G+ AV ER RD LV L L
Sbjct: 62 TLDVALLREDIDLAVHSMKDVPTALPEGICQAAVLERASARDVLV------HKGLGFLDG 115
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGW 187
I T SLRR AQ YP +V +RGN+NTRL+ L + + I A AGL R+G
Sbjct: 116 PGTIATGSLRRKAQWLNRYPAHQVTGLRGNVNTRLKLL--RENSWDGAIFAQAGLERIGL 173
Query: 188 GNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLG 247
P ML A QGA+ V R + P +H ++ V ER FL+TL
Sbjct: 174 --LPDNAEPLDWMLPAPAQGAMLVVARTSDTAAREAARPLHHEQSALEVAVEREFLRTLE 231
Query: 248 GGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEET 287
GGCSAP+G ++ D +L L G ++SLDG T
Sbjct: 232 GGCSAPIG--ARVHAADG--QLHLEGGLFSLDGKKAFRVT 267
>UniRef50_Q8NT90 Cluster: Porphobilinogen deaminase; n=5;
Corynebacterium|Rep: Porphobilinogen deaminase -
Corynebacterium glutamicum (Brevibacterium flavum)
Length = 302
Score = 166 bits (404), Expect = 8e-40
Identities = 105/278 (37%), Positives = 159/278 (57%), Gaps = 11/278 (3%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+++ +G+R S+LA Q + D LK + E IVT T GD V P+ +IG +FT
Sbjct: 1 MTLKIGTRGSKLATTQAGTIRDQLKHYGRDAELHIVT--TPGD-VNMSPVERIGV-GVFT 56
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
+ L D L S D VHS+KDLPT + V R D R+AL+ + +L+ LP
Sbjct: 57 QALRDVLHSGECDVAVHSMKDLPTATDPRFHL-VVPTRADSREALIARDGL---TLAELP 112
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
G+ +GTS+ RR +QL P L+++ +RGN++TR+ K+ G+ ++LA AGL+R+G
Sbjct: 113 EGAKVGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTS--GELDAVMLAYAGLTRVG 170
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
+R ++V ++ A QGALA+ECRAD+ E + L H +T+ +AER+ L L
Sbjct: 171 MQDRATEVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRL 230
Query: 247 GGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKL 284
GC+APV L + +TLT V++LDGS +L
Sbjct: 231 EAGCTAPVAAHATL-DGYSGDTMTLTAGVYALDGSDQL 267
>UniRef50_Q1AUK3 Cluster: Porphobilinogen deaminase; n=1;
Rubrobacter xylanophilus DSM 9941|Rep: Porphobilinogen
deaminase - Rubrobacter xylanophilus (strain DSM 9941 /
NBRC 16129)
Length = 305
Score = 166 bits (403), Expect = 1e-39
Identities = 100/245 (40%), Positives = 141/245 (57%), Gaps = 8/245 (3%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDLE 70
+G+R S LAL Q L+ E + + T+ DR D PL I ++ +FT+ L+
Sbjct: 7 LGTRGSPLALAQAEACAAGLRAAGFAVELRRIRTTS--DRRPDDPLSVIDQRDVFTRQLD 64
Query: 71 DALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSV 130
+AL++ VD VHS+KD+PT +P+G+V+ AV R DP DALV + + LP G+
Sbjct: 65 EALLAGEVDLAVHSMKDVPTEVPEGIVLAAVAGRADPSDALVSE---GGWGVDGLPEGAR 121
Query: 131 IGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNR 190
+ TSSLRR AQL P L+VV++RGN++TR+RK+ G ++LA AGL R+G
Sbjct: 122 VATSSLRRRAQLLHRRPDLRVVEIRGNVDTRIRKM--RAGAAEAVVLARAGLVRLGL-EV 178
Query: 191 MSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGGC 250
V+P +L AVGQGALAV R + + + N P V AER+ L+ L GGC
Sbjct: 179 PHAVIPHDVLLPAVGQGALAVAVRRGDPRLEEIRRALNDPAAEREVAAERALLRALEGGC 238
Query: 251 SAPVG 255
PVG
Sbjct: 239 RVPVG 243
>UniRef50_Q5YP70 Cluster: Porphobilinogen deaminase; n=18;
Actinomycetales|Rep: Porphobilinogen deaminase -
Nocardia farcinica
Length = 346
Score = 165 bits (401), Expect = 2e-39
Identities = 111/289 (38%), Positives = 165/289 (57%), Gaps = 14/289 (4%)
Query: 5 TKLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSL 64
T + +G+R S LA+ Q V D+L + ++V + T GD D P+ KIG +
Sbjct: 6 TGTPLRIGTRGSLLAMTQAGTVRDALIA--AGRPAELVVVKTPGDMSSD-PVQKIGV-GV 61
Query: 65 FTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLST 124
FT L D L + +D VHS KDLPT VI A+ REDPRDALV + L
Sbjct: 62 FTSALRDELAAGTIDLAVHSYKDLPTAPDPRFVIAAIPPREDPRDALVARDGLV---LGE 118
Query: 125 LPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSR 184
LP+G+ +GTS+ RR AQL L +V +RGNL++RL ++ D G+ +++A AGLSR
Sbjct: 119 LPAGAKVGTSAPRRVAQLRALGLGLDIVPLRGNLDSRLARVTD--GELDAVVVARAGLSR 176
Query: 185 MGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLK 244
+G +++ L +ML A QGALAVECR+++ ++ LA + T V+AER+ L
Sbjct: 177 IGRTAVITEALEPVQMLPAPAQGALAVECRSEDAALIEALAELDDAATRAAVVAERALLA 236
Query: 245 TLGGGCSAPVGISTKLKQN-DN----VYKLTLTGAVWSLDGSTKLEETL 288
L GC+APVG ++ ++ D+ V +L+L G ++DGS L ++
Sbjct: 237 ELEAGCTAPVGALAEVVESLDDDGRIVEELSLRGCAAAVDGSEVLRASV 285
>UniRef50_O29026 Cluster: Probable porphobilinogen deaminase; n=1;
Archaeoglobus fulgidus|Rep: Probable porphobilinogen
deaminase - Archaeoglobus fulgidus
Length = 289
Score = 164 bits (398), Expect = 4e-39
Identities = 98/251 (39%), Positives = 145/251 (57%), Gaps = 12/251 (4%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ + VG+R S+LAL QTN V + LK Y E E +IV T GD + D+PL + F
Sbjct: 1 MKLIVGTRGSKLALAQTNKVAERLKERY-EVEIRIVK--TAGDIMKDKPLYEFKGMGAFV 57
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
+ L+ AL VD VHS KD+P+ +G V+ AV ER+ P D L+ + +L L
Sbjct: 58 RALDTALAEGKVDVAVHSFKDVPSQRVEGTVVAAVIERDSPCDVLISRD---GSTLEELD 114
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
G+V+GTSSLRR AQL+ L+ ++RGNL+TRLRKL +G Y +++A AGL R+G
Sbjct: 115 EGAVVGTSSLRRRAQLSRLRGDLRFENLRGNLDTRLRKL--REGNYDAIVVAEAGLKRLG 172
Query: 187 WGNRMS-KVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKT 245
+ + P ++ QG +A+ R E+++A L N +T+ + ER+ +K
Sbjct: 173 LDREVEYQPFPPEVIVPPANQGIIAIATRKGEEDLVAFL---NDEKTWLEAMVERAVIKE 229
Query: 246 LGGGCSAPVGI 256
LG GC+ PVG+
Sbjct: 230 LGVGCAVPVGV 240
>UniRef50_Q82P95 Cluster: Porphobilinogen deaminase 2; n=3;
Streptomyces|Rep: Porphobilinogen deaminase 2 -
Streptomyces avermitilis
Length = 314
Score = 164 bits (398), Expect = 4e-39
Identities = 105/287 (36%), Positives = 158/287 (55%), Gaps = 12/287 (4%)
Query: 1 MDGETKLS-IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKI 59
M G + L I + SR S +AL Q V L +P ++V + T GD+ + L K+
Sbjct: 1 MSGMSALELIRIVSRDSPMALAQVARVRAELAALHPRTRTEVVAVKTTGDKWMGD-LSKV 59
Query: 60 GEKSLFTKDLEDALMSKNVDFVVHSLKDLPTT--LPDGLVIGAVFEREDPRDALVLNEKF 117
K FTK+++ AL++ D VH +KD+P LP G + A +R+D RDALV
Sbjct: 60 DGKGAFTKEVDAALLAGEADLAVHCVKDVPADRPLPAGTMFAAFLKRDDIRDALVHPGGL 119
Query: 118 KEYSLSTLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLIL 177
+L LP G+ IGTSS+RR AQL YP L+ V RGN N RL KL G+ L+L
Sbjct: 120 ---TLDELPPGTRIGTSSVRRVAQLAAAYPHLECVPFRGNANRRLEKL--AAGEADALLL 174
Query: 178 ASAGLSRMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVL 237
A +GL R+G + +++VL M+ +G G LA++CR + ++ ++ P T+
Sbjct: 175 AVSGLERIGREDVITEVLEPETMMPPIGAGILALQCREGDTGLIETISELGDPGTHREAT 234
Query: 238 AERSFLKTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKL 284
AER FL L G C++P+ + ++N +L+L +V++LDG T L
Sbjct: 235 AERMFLHVLQGHCNSPIAGYARTERNG---ELSLRASVFTLDGKTVL 278
>UniRef50_Q7UPN0 Cluster: Porphobilinogen deaminase; n=1; Pirellula
sp.|Rep: Porphobilinogen deaminase - Rhodopirellula
baltica
Length = 337
Score = 163 bits (395), Expect = 1e-38
Identities = 103/286 (36%), Positives = 153/286 (53%), Gaps = 13/286 (4%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
+ + +R+S LA+ Q V LK++ + E IV + + GD + +P+ + LFTK
Sbjct: 12 LRIATRESPLAMWQAEHVAKLLKKHGFQTE--IVPLVSKGDTDM-RPIDGTRQVGLFTKR 68
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVL--------NEKFKEY 120
++ AL+ D VHSLKDLPT V+ AV RE DALV ++ E
Sbjct: 69 IQQALVDDEADVAVHSLKDLPTEPDSRFVLAAVPPRESVLDALVFADNSPHLESQTGAES 128
Query: 121 SLSTLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASA 180
L LP G+ +GT S RR AQL P L+V+ +RGN+ TRL KL+ G++ ++LA A
Sbjct: 129 PLDYLPQGARVGTGSTRRLAQLKQLRPDLEVLPIRGNVQTRLAKLNA--GEFDAIVLAHA 186
Query: 181 GLSRMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAER 240
G+ R+ + ++ P EM+ A GQGAL +E R+D+ + +A N AER
Sbjct: 187 GILRLEMTDLPHRLFPLDEMIPAPGQGALGIEVRSDDAGAMDAIANLNDAAARLAATAER 246
Query: 241 SFLKTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEE 286
L L GGC AP+ KL+ +++ +L L V S DG +L+E
Sbjct: 247 KVLSELHGGCLAPIACHAKLETSNHGTELCLRAIVMSADGEQRLQE 292
>UniRef50_Q6L2G8 Cluster: Probable porphobilinogen deaminase; n=2;
Thermoplasmatales|Rep: Probable porphobilinogen
deaminase - Picrophilus torridus
Length = 282
Score = 162 bits (394), Expect = 1e-38
Identities = 100/250 (40%), Positives = 141/250 (56%), Gaps = 11/250 (4%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ I +G+R S+LA++Q V D L E E K T+ GD LD PL IG +F
Sbjct: 1 MHIRIGTRSSKLAMIQAMMVKDRLDSLGIETEVK--GFTSKGDINLDSPLYSIGGTGVFV 58
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
DL ++ +D VHS KD+P+ + D L I AV +R+DPRD L+ ++SL+ L
Sbjct: 59 DDLNRMILKNEIDIAVHSAKDIPSFIDDSLEISAVLKRDDPRDVLI-----SQHSLNDLE 113
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
+ SVIGTSSLRR +L + + D+RGN++TRL+KLD +G Y +I+A A RM
Sbjct: 114 ASSVIGTSSLRRIKELKTLRNDILIKDLRGNIDTRLKKLD--NGDYDGIIMAKAAYDRMR 171
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
NR +L + + A QG +A+ + D+ E+ +L N ETY + AER L L
Sbjct: 172 I-NRRHFILNYDDFVPAPNQGIIAIISKKDS-EINDVLKKINDDETYNDMKAERLILSGL 229
Query: 247 GGGCSAPVGI 256
GCS PVGI
Sbjct: 230 NLGCSKPVGI 239
>UniRef50_Q2NEP4 Cluster: HemC; n=1; Methanosphaera stadtmanae DSM
3091|Rep: HemC - Methanosphaera stadtmanae (strain DSM
3091)
Length = 290
Score = 161 bits (391), Expect = 3e-38
Identities = 94/255 (36%), Positives = 151/255 (59%), Gaps = 11/255 (4%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNYPEK-EFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDL 69
VG+R S+LA QT V+ +L+ E+ E KI+ T GD++ + L I K +FTK+L
Sbjct: 3 VGTRGSKLATTQTKTVVKALEEITGEEIETKIIKTT--GDKIKNSQLYNIDAKGIFTKEL 60
Query: 70 EDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGS 129
+ AL+ ++DF VHS KDLP+ L D L I A+ +RE + L+ N YS LP +
Sbjct: 61 DTALIDGSIDFAVHSFKDLPSELNDQLTITAIPQREAINEVLISN-----YSWDELPENA 115
Query: 130 VIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGN 189
+GTSS+RR A + +++ +RGN++TR+RK+ E+G+Y I+A AG++R+G
Sbjct: 116 TLGTSSVRREAFCKLHGKKIQTKPIRGNIDTRIRKV--EEGEYDATIMALAGINRLGLQE 173
Query: 190 RMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGG 249
+ +V + GQGALAV D+ E +++ NH ++ + E++ L+T+G G
Sbjct: 174 HIKEVFDEQYITPPAGQGALAVMTHKDS-EYNDVISKLNHEDSRIEAMTEKAILETIGVG 232
Query: 250 CSAPVGISTKLKQND 264
C P+GI +K+ N+
Sbjct: 233 CQWPIGIVSKVDGNN 247
>UniRef50_A0RXB2 Cluster: Porphobilinogen deaminase; n=2;
Thermoprotei|Rep: Porphobilinogen deaminase -
Cenarchaeum symbiosum
Length = 311
Score = 160 bits (388), Expect = 7e-38
Identities = 103/287 (35%), Positives = 149/287 (51%), Gaps = 12/287 (4%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDLE 70
VG+R S L+L QT V+D+LK PE E+K+ + T GD D+PL I +K +F K+++
Sbjct: 6 VGTRGSRLSLAQTGHVLDALKEANPEDEYKVRRIKTQGDTD-DRPLFAIDQKGIFEKEID 64
Query: 71 DALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSV 130
A+ DF VHSLKD+PT L GLV+ V R D LV L +LP G+
Sbjct: 65 RAVSEGGADFAVHSLKDVPTELAPGLVLACVPRRAAANDVLV---SPGGSGLGSLPRGAT 121
Query: 131 IGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNR 190
+GTSSLRR Q+ + L V VRGN+ TR+ K+ Y ++LA AG+SR+G +
Sbjct: 122 VGTSSLRRAVQVGRSRSDLHVKPVRGNIETRIAKV---GAGYDAVVLAEAGISRLGLDVK 178
Query: 191 MSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGGC 250
+ LP + GQG+LA+ R+ + ++ML + AER+ + +G GC
Sbjct: 179 YA-ALPEESFAPSPGQGSLALVARSGDAGTISMLNRIEDAASRAEAEAERALSERIGSGC 237
Query: 251 SAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRK 297
PVG + LT+ +S+DGS + G RK
Sbjct: 238 RFPVGALARSAGE----LLTIRAEAFSVDGSRSVSVQASGPRGSPRK 280
>UniRef50_A6LKX0 Cluster: Porphobilinogen deaminase; n=1;
Thermosipho melanesiensis BI429|Rep: Porphobilinogen
deaminase - Thermosipho melanesiensis BI429
Length = 279
Score = 159 bits (386), Expect = 1e-37
Identities = 90/253 (35%), Positives = 145/253 (57%), Gaps = 17/253 (6%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ I VG+RKS+LAL+QT V++ LK P +F+I + T GDR L P+ KIG K +F
Sbjct: 1 MKIRVGTRKSKLALIQTQLVVNKLKELLPNIDFEITPVVTKGDR-LKTPIDKIGGKGVFV 59
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
D+E ++ +D +HS+KDLP+ +PD L + +V +RE P D + E F L
Sbjct: 60 SDIEKLILDDKLDIAIHSMKDLPSKIPDKLFLTSVLKRECPNDVFIGKENF-----FNLK 114
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
G+ IGTSS RR Q+N P +++V +RGN++TR++K+ + DG +++A+AG+ R+G
Sbjct: 115 KGAKIGTSSKRRALQINMLRPDIEIVPIRGNVDTRIKKIGELDG----IVIAAAGVIRLG 170
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECR----ADNEEVLAMLAPFNHPETYCRVLAERSF 242
++++ + +++ A QG LA+E EE+ ++ P+T ER
Sbjct: 171 LKDKITNLFEFEKIVPAPCQGILALEFSEKFLKPFEEIKDVIV---DPKTEVETQIERKI 227
Query: 243 LKTLGGGCSAPVG 255
L L C+ P G
Sbjct: 228 LSLLNFDCNTPFG 240
>UniRef50_A5CNI4 Cluster: HemC protein; n=2; Actinobacteria
(class)|Rep: HemC protein - Clavibacter michiganensis
subsp. michiganensis (strain NCPPB 382)
Length = 328
Score = 157 bits (382), Expect = 4e-37
Identities = 102/281 (36%), Positives = 153/281 (54%), Gaps = 15/281 (5%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
++ +G+R S LAL QT + + E ++V +TT GD + L +G +F
Sbjct: 13 TLRIGTRGSALALAQTRAIAAEIT-GASGLEVELVPVTTHGDTSRES-LSSLGGTGVFAS 70
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
L ++L+ D VVHSLKDLPT GL + +V REDPRD L + +L+TLP
Sbjct: 71 ALRESLLRGECDLVVHSLKDLPTAPYAGLTVASVPVREDPRDVLCARDGL---TLATLPR 127
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGW 187
G+ +GT S RR AQ+ P L VVD+RGN++TRL ++ G ++LA+AGL R+G
Sbjct: 128 GARVGTGSPRRRAQILAERPDLDVVDIRGNIDTRLSRV--TAGDLDAVVLAAAGLERIGR 185
Query: 188 GNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLA----PFNHPETYCRVLAERSFL 243
+ ++ L A GQGALA+E R ++ E +++ + P T+ VLAER L
Sbjct: 186 IDAATEHLELDRWPTAPGQGALALEIRTEDAETHSVVGRAVEAVDDPFTHAAVLAERGVL 245
Query: 244 KTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKL 284
L GC+AP+G + +L LT V+ DG+ ++
Sbjct: 246 AALEAGCAAPIGAWATVTS----ARLALTAVVYRPDGTQRM 282
>UniRef50_Q6AB05 Cluster: Porphobilinogen deaminase; n=17;
Actinomycetales|Rep: Porphobilinogen deaminase -
Propionibacterium acnes
Length = 334
Score = 157 bits (380), Expect = 7e-37
Identities = 111/292 (38%), Positives = 157/292 (53%), Gaps = 19/292 (6%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
+I +G+R S LA Q+ V L+ + + T+TT GD L +G +F
Sbjct: 3 AIRLGTRASTLATTQSEMVAGLLRSE--GLDVNLTTITTHGD-TSTASLAAMGGIGVFAS 59
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
+ AL+ D VHS KDLPT P GL IGAV R DPRDALV + +L LP
Sbjct: 60 AIRAALLEGEADIAVHSFKDLPTGRPLGLAIGAVPARADPRDALVARDGL---TLHDLPQ 116
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDD-----EDGKYSDL---ILAS 179
+ +GT S RR AQL P L +VD+RGN++TRL ++ ++G DL +LA+
Sbjct: 117 EASVGTGSPRRAAQLLAVRPDLTIVDIRGNVDTRLGRVKGLGRYAKNGGKEDLDAVVLAA 176
Query: 180 AGLSRMGWGNRMSKVLPCSEMLYAVGQGALAVECR-ADNE--EVLAMLAPFNHPETYCRV 236
+GL+R+G +++ L S +L A QGALAVECR AD+ ++ LA + T
Sbjct: 177 SGLARLGHSGAVTEFLDPSVVLPAPAQGALAVECRTADSRHGKLAKALARIDDRRTRLAA 236
Query: 237 LAERSFLKTLGGGCSAPVGISTKLK--QNDNVYKLTLTGAVWSLDGSTKLEE 286
AER+ L L GC+AP+G +LK ++ LTL V ++DGS + E
Sbjct: 237 TAERAVLSHLEAGCAAPIGALAQLKPVSGKSLQVLTLDVVVAAVDGSRTVRE 288
>UniRef50_Q9ABZ8 Cluster: Porphobilinogen deaminase; n=2;
Caulobacter|Rep: Porphobilinogen deaminase - Caulobacter
crescentus (Caulobacter vibrioides)
Length = 322
Score = 156 bits (379), Expect = 9e-37
Identities = 100/257 (38%), Positives = 143/257 (55%), Gaps = 16/257 (6%)
Query: 9 IHVGSRKSELALVQTNF----------VIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPK 58
I +G+R S+L+L Q+ V ++ E ++ + T GDR+ D+ L +
Sbjct: 7 IRIGARGSKLSLAQSGLMQARIAHALGVPAGASKDEIEAAAPLIPIVTSGDRIQDRRLME 66
Query: 59 IGEKSLFTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFK 118
IG K LFTK++E+AL+ +D VHSLKD+P LP GLV+ A EREDPRDA + + +
Sbjct: 67 IGGKGLFTKEIEEALLDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFISHVCER 126
Query: 119 EYSLSTLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILA 178
L LP G+ +GT+SLRR AQ P L++V +RGN++TRL KL E G+ ++LA
Sbjct: 127 ---LEDLPKGARLGTASLRRQAQALHVRPDLEIVMLRGNVDTRLAKL--ERGEADAILLA 181
Query: 179 SAGLSRMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLA 238
+GL+R+G G+ L A GQGAL +E RA++ L +T V A
Sbjct: 182 QSGLNRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIGA-PWLEAVRCRQTTIAVAA 240
Query: 239 ERSFLKTLGGGCSAPVG 255
ER L L G C +G
Sbjct: 241 ERGALLALEGSCRTAIG 257
>UniRef50_A4XK06 Cluster: Porphobilinogen deaminase; n=1;
Caldicellulosiruptor saccharolyticus DSM 8903|Rep:
Porphobilinogen deaminase - Caldicellulosiruptor
saccharolyticus (strain ATCC 43494 / DSM 8903)
Length = 290
Score = 154 bits (374), Expect = 3e-36
Identities = 93/259 (35%), Positives = 140/259 (54%), Gaps = 8/259 (3%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
+ +G+R S+L+ +Q + V +K+ E + V + T GD + L +F K+
Sbjct: 4 LRIGARDSKLSRIQVDIVARKIKQTLGI-ECEFVPIKTKGDIDKTKSLKDFKSPGVFVKE 62
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
+E AL+S+ +D VHSLKDLP + I AV EREDPRD LV + Y L P+
Sbjct: 63 IELALLSREIDLAVHSLKDLPCEMDSNFEIVAVVEREDPRDVLVSKDGVGFYQLK--PNA 120
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
IGTSSLRR L ++VV++RGN+ TRL K++ E ++LA A L R+
Sbjct: 121 K-IGTSSLRREVHLKNLRQDIQVVNIRGNIETRLSKIESEG--LDGVVLAYAALKRLNLD 177
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
+ +S + +E+ GQGA+ +EC D+ +L+ N + Y + ER LK LGG
Sbjct: 178 SHVSYIFDVNEITPCPGQGAICIECLKDS-PYKNILSKINDADAYIQTQFERLVLKFLGG 236
Query: 249 GCSAPVGISTKLKQNDNVY 267
GC + +G+ K Q D +Y
Sbjct: 237 GCHSSIGVFCKTDQ-DKIY 254
>UniRef50_Q8D2W2 Cluster: HemC protein; n=1; Wigglesworthia
glossinidia endosymbiont of Glossina brevipalpis|Rep:
HemC protein - Wigglesworthia glossinidia brevipalpis
Length = 291
Score = 154 bits (373), Expect = 5e-36
Identities = 89/281 (31%), Positives = 152/281 (54%), Gaps = 8/281 (2%)
Query: 34 YPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKDLEDALMSKNVDFVVHSLKDLPTTLP 93
+P+ K+V + T GD + EK LF K+LE +L+ D VHS+KD ++
Sbjct: 14 HPKLNIKLVPILTTGDLINKIRNNITNEKGLFIKELEKSLLKYQSDIAVHSMKDFSSSFL 73
Query: 94 DGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSVIGTSSLRRTAQLNGNYPQLKVVD 153
D L + A+ +R+DPRDA+V N ++ +LP+ + +GTSSLRR QL P LK+
Sbjct: 74 DSLGLAAICKRDDPRDAIVSNYY---NNIISLPNNAKVGTSSLRRKCQLLSIRPDLKIFP 130
Query: 154 VRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNRMSKVLPCSEMLYAVGQGALAVEC 213
+GN+++RL+KL+ G + LILA+A L R+ +M + S +L A+GQG++A++C
Sbjct: 131 CKGNIHSRLKKLNQ--GVFDALILATAALKRLKINEQMYTPIDPSYLLPAMGQGSIAIQC 188
Query: 214 RADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGGCSAPVGISTKLKQNDNVYKLTLTG 273
R + +++ ++ N+ +T + +E+ + LG GC P+G K++ + ++ L G
Sbjct: 189 RLYDNKIIDIVRNINNKKTALCINSEKIVVSMLGTGCRVPIGSYAKIENKNTIWIRALVG 248
Query: 274 AVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTEEASSKKI 314
S+DGS + K K ++ +K I
Sbjct: 249 ---SIDGSNIIRSEGKSCVSNAEKLSKKQVKNLINLGAKNI 286
>UniRef50_Q2GE22 Cluster: Putative porphobilinogen deaminase; n=1;
Neorickettsia sennetsu str. Miyayama|Rep: Putative
porphobilinogen deaminase - Neorickettsia sennetsu
(strain Miyayama)
Length = 286
Score = 151 bits (367), Expect = 2e-35
Identities = 94/257 (36%), Positives = 143/257 (55%), Gaps = 12/257 (4%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
LS+ VG+R S LAL+Q V +L + +V + T GD V D PL ++G K+LF
Sbjct: 2 LSLKVGTRCSPLALIQARLVERALAPYCARTD--LVEVKTSGDIVSDVPLTEVGGKALFL 59
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
K+LE+ L++ +D VHS+KD+P D L + V +R P D V F+ ++ +LP
Sbjct: 60 KELEEKLLTGEIDIAVHSMKDVPAFYHDDLEVVPVLKRAIPNDVFV---SFRYPNMLSLP 116
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
+G+VIGT + RR QLN + +V+ +RGN+ TR+ K + DG +ILA L R+G
Sbjct: 117 NGAVIGTCAPRRVVQLNQRF---RVIPLRGNIATRIEKAKNLDG----IILAFCALERLG 169
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
+S+V+ + ML V QGAL VE R + + ++ + ET AER+FL+ +
Sbjct: 170 LRRMISEVIHENVMLPGVAQGALCVEFRKKDRFLRELILNISDRETIICTAAERAFLEEI 229
Query: 247 GGGCSAPVGISTKLKQN 263
G C +G +K N
Sbjct: 230 NGDCKTALGALAIVKNN 246
>UniRef50_A4BYX0 Cluster: Porphobilinogen deaminase HemC; n=11;
Bacteroidetes|Rep: Porphobilinogen deaminase HemC -
Polaribacter irgensii 23-P
Length = 531
Score = 151 bits (365), Expect = 4e-35
Identities = 116/340 (34%), Positives = 163/340 (47%), Gaps = 16/340 (4%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKR-NYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
I +G+R S+LAL Q N V L Y E +V + + GD LD PL ++G +FTK
Sbjct: 5 IRIGTRDSQLALWQANKVRKELAGLGY---ESVLVPIKSSGDINLDTPLYEMGITGIFTK 61
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
L+ AL+ +D VHSLKD+PT LP G+V AV +R + D LVLN + +
Sbjct: 62 SLDIALLEGKIDIAVHSLKDVPTALPKGIVQAAVLKRGNYNDVLVLNGTEEFFG----EE 117
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGW 187
+I T SLRR A YP KV +RGN+ TRL KL+ ++ + A+AGL R+G
Sbjct: 118 QGLIATGSLRRKAMWLDRYPTHKVAPLRGNVQTRLEKLETSK-TWNGAVFAAAGLERLGI 176
Query: 188 GNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLG 247
+ LP ML A QGA+ + ++ L NH ET V ER FL+ L
Sbjct: 177 TPEDTVDLPW--MLPAPAQGAIMIAALEKDDFTLDACEQINHHETSVCVGVEREFLRLLE 234
Query: 248 GGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTE 307
GGC+AP+G + + ++ + DGS K+ FG + K
Sbjct: 235 GGCTAPIGALAYVDARTD--EVNFKAVLLKKDGSKKIRVAKTAKFGSHKFLAKDCADYVI 292
Query: 308 EASSKKIKTDKTVEA-DNEIAVLNRRITDKTGDLGCEDLA 346
K++ V A D IA + T K +L E L+
Sbjct: 293 NRGGKEMMAADEVSAKDPRIAAVYS--TKKLSELQKETLS 330
>UniRef50_Q8ZYW7 Cluster: Probable porphobilinogen deaminase; n=3;
Pyrobaculum|Rep: Probable porphobilinogen deaminase -
Pyrobaculum aerophilum
Length = 297
Score = 149 bits (360), Expect = 2e-34
Identities = 88/251 (35%), Positives = 139/251 (55%), Gaps = 7/251 (2%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ + V +R S L+L+QT + +K P +F+I + T GD V D+PL +IG K +F
Sbjct: 1 MRLKVATRGSRLSLLQTEEFLAQIKAVEPRVDFEIKIVKTTGDLVQDKPLFQIGVKGIFE 60
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
K++ A++ D +HSLKDLP+ + GLV+ +R P DA+V Y L +LP
Sbjct: 61 KEVNLAVLKGEADIAIHSLKDLPSEISPGLVLAGFSKRTLPYDAVV---SAVGYDLESLP 117
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRM- 185
G+++GTSS+RR + P +++ +RGN++TR++K+ GKY ++A+AG+ R+
Sbjct: 118 KGALVGTSSVRRAEFIKSLRPDVRIEPLRGNVDTRVQKI--LQGKYDAAVMAAAGILRLY 175
Query: 186 GWGNRMSKVLPCSEML-YAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLK 244
G + L E+L GQG +A R ++ +L + P LAER FLK
Sbjct: 176 GESPPVKLSLLRPELLPPPPGQGIVAAVVREGEGWLIDLLKKASDPRATVEALAEREFLK 235
Query: 245 TLGGGCSAPVG 255
+G GC VG
Sbjct: 236 NVGAGCHVAVG 246
>UniRef50_Q5NL83 Cluster: Porphobilinogen deaminase; n=1; Zymomonas
mobilis|Rep: Porphobilinogen deaminase - Zymomonas
mobilis
Length = 308
Score = 144 bits (349), Expect = 4e-33
Identities = 91/261 (34%), Positives = 144/261 (55%), Gaps = 11/261 (4%)
Query: 6 KLSIHVGSRKSELALVQTNFVIDSL--KRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKS 63
+L +GSR S LAL+Q V +L ++ E IV + T GD+ Q L IG K+
Sbjct: 2 QLPFRLGSRGSPLALIQARSVASALCAAHSWSEDAVVIVPIRTSGDKNRHQALADIGGKA 61
Query: 64 LFTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLS 123
L+TK+L+ AL + +D VHS+KD+ T P + I A+ RED D L+ SL
Sbjct: 62 LWTKELDIALTTGQIDAAVHSMKDVETFRPSHISIAAMLPREDVHDRLI-----GIPSLE 116
Query: 124 TLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLS 183
LP +GT+S RR AQ+ P +++ +RGN++TRL KL ++ ++ +LA+AGL
Sbjct: 117 VLPYSGCVGTASPRRAAQIRRIRPDIEIKLLRGNIDTRLEKLANK--QFDATLLAAAGLI 174
Query: 184 RMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFL 243
R+G N + +P +ML A GQGA+ +E AD+ ++ +H T+ V +ER L
Sbjct: 175 RLG-RNDVGYDVPLDQMLPAAGQGAIGIEALADS-AAWEKVSIIDHYPTHLAVQSERQLL 232
Query: 244 KTLGGGCSAPVGISTKLKQND 264
L C +P+ + ++ + +
Sbjct: 233 LRLNADCHSPIAVFAEILEKN 253
>UniRef50_Q2FTK7 Cluster: Porphobilinogen deaminase; n=1;
Methanospirillum hungatei JF-1|Rep: Porphobilinogen
deaminase - Methanospirillum hungatei (strain JF-1 / DSM
864)
Length = 295
Score = 142 bits (345), Expect = 1e-32
Identities = 92/253 (36%), Positives = 139/253 (54%), Gaps = 14/253 (5%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ + VG+R SELA Q V L+ + E +V ++T GD PL +IG + +F
Sbjct: 1 MPLRVGTRASELAKAQAVKVCTMLEDLGVDTE--LVFISTAGDEQTGVPLHEIGGQGVFV 58
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
+ L+DAL+ +D VHS+KD+P P GLV A+ R+ P D +V + + E ++TL
Sbjct: 59 RALDDALVQNKIDLAVHSMKDIPAERPYGLVTSAILARDSPCDYIVTDHELDE--ITTL- 115
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
GTSS RRTAQ N P + +RGN+NTRL KL + G+Y ++LA AGL R+
Sbjct: 116 -----GTSSTRRTAQCRRNLPWADIRPLRGNVNTRLSKL--QSGEYDAIMLAKAGLERLS 168
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
++ P + + QG +AV R D +V +++ + P+T L ER ++ +
Sbjct: 169 MTLDGYQLDP-RVHVPSPNQGTIAVVSRTD-PDVTDIISKIDDPKTRMDTLLERRVMEMI 226
Query: 247 GGGCSAPVGISTK 259
GGGC P+GI K
Sbjct: 227 GGGCFTPLGIYCK 239
>UniRef50_UPI00015BAF19 Cluster: hydroxymethylbilane synthase; n=1;
Ignicoccus hospitalis KIN4/I|Rep: hydroxymethylbilane
synthase - Ignicoccus hospitalis KIN4/I
Length = 304
Score = 142 bits (344), Expect = 1e-32
Identities = 89/251 (35%), Positives = 133/251 (52%), Gaps = 8/251 (3%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLD--QPLPKIGEKSL 64
+ I + +R S+L+L Q + L + +P+ E++++T+ T GD+ + L K G L
Sbjct: 1 MKIKIAARGSKLSLKQVSMFTSYLLKFFPDLEYEVITVKTTGDKANAPFEELAKRGLTGL 60
Query: 65 FTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLST 124
F K++ A++ D VHSLKDLPT L L I A R+ P D L+ + Y +
Sbjct: 61 FEKEVNKAVLEGKADVAVHSLKDLPTELDPRLEIAAFLPRDPPYDVLI--SRAGNYDIFD 118
Query: 125 LPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSR 184
LP GSV+GTSS RR A + P L V D+RGN++TRL KL G+Y ++LA AG+SR
Sbjct: 119 LPKGSVVGTSSARRKALIKNLRPDLVVKDLRGNVDTRLEKL--RRGEYDAIVLAEAGVSR 176
Query: 185 MGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLK 244
+G + L + GQG + R E+ +L + ++ AER+ LK
Sbjct: 177 LGLNVDYVR-LDWRLFPPSPGQGIIVAVTR-KGSEISDLLKSISDVKSEKLATAERTVLK 234
Query: 245 TLGGGCSAPVG 255
GGGC +G
Sbjct: 235 EFGGGCFVALG 245
>UniRef50_Q93A65 Cluster: Porphobilinogen deaminase; n=1; uncultured
bacterium|Rep: Porphobilinogen deaminase - uncultured
bacterium
Length = 299
Score = 141 bits (341), Expect = 3e-32
Identities = 90/251 (35%), Positives = 140/251 (55%), Gaps = 10/251 (3%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
+ + +R S LAL Q +V L + E E +V + T GDR +P ++ + FTK
Sbjct: 4 VRLATRGSRLALWQAEWVAKQLVQQGAEVE--LVVVETQGDRE-KRPFAQMQGQGFFTKA 60
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP-- 126
+++A++ DF VHS KDLP+ P GL I AV REDPR+ L++ + + LP
Sbjct: 61 VQEAVLEGRADFAVHSYKDLPSARPAGLEIAAVPPREDPRELLLVRLQAVDQVAPGLPLR 120
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
+G+ +G+S+ RR AQL P L ++++RGN+ TR+ KL G+Y ++LA AG+ R+G
Sbjct: 121 AGARVGSSAARRQAQLAHLRPDLSLLELRGNVLTRVEKL--RQGEYDAVLLAYAGVRRLG 178
Query: 187 WGNRMS--KVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLK 244
+VLP + ++ A QGALA+ECR D++ + +L P + P R +
Sbjct: 179 LDLSPFHWQVLPPTLLVPAPAQGALALECRQDDKRLRPLLEPLDDPSAGVR-CGGAGLMA 237
Query: 245 TLGGGCSAPVG 255
L GGC +G
Sbjct: 238 RLAGGCQLALG 248
>UniRef50_Q2JFS0 Cluster: Porphobilinogen deaminase; n=2;
Frankia|Rep: Porphobilinogen deaminase - Frankia sp.
(strain CcI3)
Length = 395
Score = 138 bits (334), Expect = 2e-31
Identities = 86/205 (41%), Positives = 124/205 (60%), Gaps = 7/205 (3%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
+ +G+R+S LAL Q+ V +L+ ++V + T GDR + + +IG +F
Sbjct: 42 LRLGTRRSALALAQSGTVAATLRARVG-CAVELVPIVTAGDRSSGE-ISQIGGTGVFVSA 99
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
L DAL+S +D VHSLKDLPT P GLV+ AV R DPRD LV + L+ L +G
Sbjct: 100 LRDALLSGEIDLAVHSLKDLPTATPPGLVLAAVPPRADPRDVLVAPSGRR---LAELRAG 156
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
+ I T S RR AQL L+VV +RGN++TRL+K DG+ ++LA AGL+R+
Sbjct: 157 ARIATGSPRRAAQLRALGLGLEVVTIRGNVDTRLKKA--IDGEVDAVVLAHAGLARLDRL 214
Query: 189 NRMSKVLPCSEMLYAVGQGALAVEC 213
+ ++++L + ML A GQGALA+EC
Sbjct: 215 DAVTEILEPTVMLPAPGQGALAIEC 239
>UniRef50_UPI000155526F Cluster: PREDICTED: similar to
hydroxymethylbilane synthase; n=1; Ornithorhynchus
anatinus|Rep: PREDICTED: similar to hydroxymethylbilane
synthase - Ornithorhynchus anatinus
Length = 218
Score = 137 bits (331), Expect = 6e-31
Identities = 69/117 (58%), Positives = 86/117 (73%), Gaps = 1/117 (0%)
Query: 78 VDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSVIGTSSLR 137
VD VVHSLKDLPT LP G IGAV +RE P DA+V + K +L+TLP SV+GTSSLR
Sbjct: 90 VDLVVHSLKDLPTVLPPGFTIGAVCKRESPYDAVVFHPKHVGKTLATLPEKSVVGTSSLR 149
Query: 138 RTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNRMSKV 194
R AQL +P L+ +RGNLNTRLRKL DE ++S +ILA+AGL R+GW +R+ +V
Sbjct: 150 RAAQLQRKFPHLEFKSIRGNLNTRLRKL-DELQEFSAIILAAAGLQRLGWQSRLGQV 205
>UniRef50_Q3W4S6 Cluster: Porphobilinogen deaminase; n=1; Frankia
sp. EAN1pec|Rep: Porphobilinogen deaminase - Frankia sp.
EAN1pec
Length = 354
Score = 137 bits (331), Expect = 6e-31
Identities = 99/267 (37%), Positives = 145/267 (54%), Gaps = 27/267 (10%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
+ +G+R+S LA Q+ V ++L+ + ++V + T GD+ + +IG +F
Sbjct: 20 LRLGTRRSALARAQSEKVAETLRTRL-SRPVELVPIVTAGDQS-QVAISQIGGTGVFVSA 77
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
L DAL++ +D VHSLKDLPT PDGLV+ AV R D RD LV + LS L G
Sbjct: 78 LRDALLAGEIDLAVHSLKDLPTATPDGLVLAAVPRRADTRDVLVSPSGRR---LSELGPG 134
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
+ +GT S RR AQL +VV +RGN++TR++K DG+ ++LA AGL R+
Sbjct: 135 ARVGTGSPRRAAQLLALGHGFEVVPIRGNVDTRIKKA--IDGEVDAVVLAHAGLDRLDRL 192
Query: 189 NRMSKVLPCSEMLYAVGQGALAVEC---------RADN---------EEVLAMLAPF--N 228
+ +++++ ML A GQGALA+EC D +E LA L F +
Sbjct: 193 DAVTEIISPEVMLPAPGQGALAIECVRTPAGGGPAHDQTGPEAGRGFDEGLAELLRFVLD 252
Query: 229 HPETYCRVLAERSFLKTLGGGCSAPVG 255
+ V AER+FL + GC+APVG
Sbjct: 253 DATSSVAVRAERAFLAGIEAGCTAPVG 279
>UniRef50_A4YD92 Cluster: Porphobilinogen deaminase; n=1;
Metallosphaera sedula DSM 5348|Rep: Porphobilinogen
deaminase - Metallosphaera sedula DSM 5348
Length = 290
Score = 134 bits (325), Expect = 3e-30
Identities = 91/257 (35%), Positives = 136/257 (52%), Gaps = 14/257 (5%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ I + +R S+L+L Q V L+ E EF + + T D ++PL +IG K +F
Sbjct: 1 MKIRIAARGSKLSLKQVEIVTTYLQAKGYETEF--IEIKTKADLFGNKPLHEIG-KGVFE 57
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
K++ +A++ D VHS+KD+ + LP GL + A +RE+P D LV E +L LP
Sbjct: 58 KEVNEAVLQGRADIAVHSMKDMSSELPPGLELLATPKRENPVDVLV-----SELNLEELP 112
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
S IGT SLRR L P L V ++RGN++TRLRK D + Y +ILA AGL R+G
Sbjct: 113 EKSRIGTGSLRRANFLKVVRPDLVVENIRGNVDTRLRKYRDHE--YDGIILAEAGLRRLG 170
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
+ L QG +AV + + L + N T LAE+ +K +
Sbjct: 171 VEVKRFP-LDVESFTPEPNQGIIAV---VGSPKFLGLFQELNDTGTMKEALAEKETVKVV 226
Query: 247 GGGCSAPVGISTKLKQN 263
GGGC +P+G+ +L+ +
Sbjct: 227 GGGCHSPLGVLFRLEDD 243
>UniRef50_A4YPB9 Cluster: Porphobilinogen deaminase; n=8;
Bradyrhizobiaceae|Rep: Porphobilinogen deaminase -
Bradyrhizobium sp. (strain ORS278)
Length = 325
Score = 133 bits (322), Expect = 7e-30
Identities = 99/289 (34%), Positives = 144/289 (49%), Gaps = 19/289 (6%)
Query: 11 VGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKS-LFTKDL 69
+G+RKS +AL QT + L+ P + +IV T GD L G K F ++
Sbjct: 6 IGTRKSTMALAQTEEIARRLQAAIPSLDIEIVKFETTGDSDQTSKLLTHGGKGGAFVAEI 65
Query: 70 EDALMSKNVDFVVHSLKDLP-TTLPDGLVIGAVFEREDPRDALVLNEKFK-EYSLSTLPS 127
A++ + +HSLKD+P GLVI A+ R+ P D LVL + E
Sbjct: 66 RRAMLDGKLHAAMHSLKDMPGNEETPGLVIAALLSRDPPGDVLVLRKGLALEDFRKDGGR 125
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDED----------GKYSDLIL 177
G IGT+++RR A +P +++ RG +TR+RKLD+ + G LI+
Sbjct: 126 GFKIGTNAVRRAAYARRLFPHAELIHFRGAADTRIRKLDNGELQRMPDGGAVGPADALIM 185
Query: 178 ASAGLSRMGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVL 237
A +GL R+G +R S P ++ML AVGQG +AVEC A + E +LA +
Sbjct: 186 ARSGLERVGLSDRASHEFPVADMLPAVGQGIVAVECPASDFETRRILATVDDAAARTCAD 245
Query: 238 AERSFLKTLGGGCSAPV-GISTKLKQNDNVYKLTLTGAVWSLDGSTKLE 285
AER L L G C++P+ G ST D ++TLT +V DG +E
Sbjct: 246 AEREVLWVLNGHCNSPIAGFST----IDGA-QMTLTASVLDEDGGRFIE 289
>UniRef50_Q97B26 Cluster: Probable porphobilinogen deaminase; n=2;
Thermoplasma|Rep: Probable porphobilinogen deaminase -
Thermoplasma volcanium
Length = 297
Score = 128 bits (310), Expect = 2e-28
Identities = 84/253 (33%), Positives = 133/253 (52%), Gaps = 11/253 (4%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ I +G+R S LA+ Q N V SL+ + E IV + GD P+ IG+ +F
Sbjct: 1 MKIKIGTRPSNLAVAQANMVASSLEAIGIDTE--IVKHRSAGDIDTKNPIYSIGKTGVFV 58
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
+DL + ++ +D VHS KD+P+ + + L I A +R DALV +Y L +LP
Sbjct: 59 QDLNNMILRGEIDVAVHSAKDIPSEIENRLTIAATLKRGSFNDALV-----SKYDLRSLP 113
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
+ +GTSS+RR QL LK ++RGN+ TR+ K+ + +++A A + R+G
Sbjct: 114 ISAKVGTSSIRRIFQLKYARQDLKFENIRGNIETRIAKMSELG--LDAIVMAEAAIQRLG 171
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
SK L ++ + A QG +AV + + V +L N T+ + ERS ++ L
Sbjct: 172 LNVEYSK-LDENKFVPAPNQGIIAVVSKKEG-TVRKILEEINDENTFEEMQIERSVVQQL 229
Query: 247 GGGCSAPVGISTK 259
GCS PVGI ++
Sbjct: 230 KLGCSTPVGILSR 242
>UniRef50_Q8EY46 Cluster: Porphobilinogen deaminase; n=4;
Leptospira|Rep: Porphobilinogen deaminase - Leptospira
interrogans
Length = 547
Score = 126 bits (303), Expect = 1e-27
Identities = 103/291 (35%), Positives = 142/291 (48%), Gaps = 43/291 (14%)
Query: 3 GETKLS--IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIG 60
G T LS + +GSRKS LA +QT V+ +LK+ +PE + ++ GD+ L PL K+G
Sbjct: 2 GRTDLSRILKIGSRKSALAKLQTYLVLGALKKKFPEIQVELFFREASGDQDLQTPLWKMG 61
Query: 61 EKSLFTKDLEDALMSKNVDFVVHSLKDLPTT-LPDGLVIGAVFEREDPRDALVLNEKFKE 119
K +FT+DL L+ K VD V+HS KDL PD +IG V +R D RD L+ +K+
Sbjct: 62 TKGVFTQDLTADLVEKKVDIVIHSWKDLDLEGHPDTTIIG-VLDRADQRDVLL----WKK 116
Query: 120 YSLSTL-PSGSVIGTSSLRR--------TAQLNGNYPQLKVV--DVRGNLNTRLRKLDDE 168
SLS PS I TSS RR + L Y +V +RGN+ TR+RK +
Sbjct: 117 SSLSKYSPSVLKIHTSSPRREYNLRKFLSFSLPSRYTNSSLVFLPIRGNIQTRIRKWKES 176
Query: 169 DGKYSDLILASAGLSRM----------------------GWGNRMSKVLPCSEMLYAVGQ 206
D L+LA A L R+ + ++ P S A GQ
Sbjct: 177 DS--DGLVLAKAALDRLLSEDFFNSDELEYQEIRKFLKDSMDESVYQIFPLSLNPTAPGQ 234
Query: 207 GALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGGCSAPVGIS 257
GA+A E R ++ VL + + E V ER LK GGGC +G+S
Sbjct: 235 GAIAAEVRTEDNWVLDRIRTLSKSEVVLAVEEERKILKRFGGGCHQKIGVS 285
>UniRef50_Q1EPC8 Cluster: Porphobilinogen deaminase, chloroplast
(Hydroxymethylbilane synthase) (Pre-uroporphyrinogen
synthase), putative; n=1; Musa acuminata|Rep:
Porphobilinogen deaminase, chloroplast
(Hydroxymethylbilane synthase) (Pre-uroporphyrinogen
synthase), putative - Musa acuminata (Banana)
Length = 328
Score = 125 bits (302), Expect = 2e-27
Identities = 91/278 (32%), Positives = 132/278 (47%), Gaps = 39/278 (14%)
Query: 14 RKSELALVQTNFVIDSLKRNYPEKE----FKIVTMTTLGDRVLDQPLPKIGEKSLFTKDL 69
R S+LAL Q D LK + E +I+ + T GD +LD+PL IG K LFTK++
Sbjct: 54 RDSDLALAQARETRDKLKAAHSELAEEGAVEIIIIKTTGDMILDKPLADIGGKGLFTKEI 113
Query: 70 EDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGS 129
+DAL+ +D VHS+KD+PT LP+G ++ R + + L PS
Sbjct: 114 DDALLQGRIDIAVHSMKDVPTYLPEGTILPCNLPASLRRQSQI---------LCRYPSLK 164
Query: 130 VIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGN 189
V+ L GN + TRL KL ++G +LA AGL R+
Sbjct: 165 VV---------NLRGN------------VQTRLTKL--KNGDVHATLLALAGLKRLNMVE 201
Query: 190 RMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGG 249
++ +L EML AV QGA+ + CR+++ +++ L+ NH +T V ER FL L G
Sbjct: 202 NVTSILSMEEMLPAVAQGAIGIACRSNDNKMMEYLSSLNHEDTRSAVACEREFLTVLDGN 261
Query: 250 CSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEET 287
C P+ D + G + S DGS E T
Sbjct: 262 CRTPI---AAYAHRDKDGSCSFRGLLASPDGSKVYETT 296
>UniRef50_Q83H95 Cluster: Porphobilinogen deaminase; n=2; Tropheryma
whipplei|Rep: Porphobilinogen deaminase - Tropheryma
whipplei (strain TW08/27) (Whipple's bacillus)
Length = 321
Score = 123 bits (297), Expect = 7e-27
Identities = 81/220 (36%), Positives = 116/220 (52%), Gaps = 13/220 (5%)
Query: 65 FTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLST 124
F L AL+ D VHSLKD+P +G +I AV REDP D L K+ +L+T
Sbjct: 50 FVAALRTALLEGECDLAVHSLKDIPIAPHEGTLITAVLPREDPCDVLCAR---KDLTLTT 106
Query: 125 LPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSR 184
LPSG+ +GT+S RR AQ+ P L VV +RGN++ RL LD D ++L++AGL R
Sbjct: 107 LPSGAKVGTASARRRAQILNFRPDLDVVSLRGNIDKRLIHLDTLDA----IVLSAAGLKR 162
Query: 185 MGWGNRMSKVLPCSEMLYAVGQGALAVE-CRA---DNEEVLAMLAPFNHPETYCRVLAER 240
+ + +++ + A GQG+LA+E CRA D + +A+ ++P AER
Sbjct: 163 IDREDAITESFDIHDWPTAAGQGSLAIEVCRAQLDDPQNRVAVTYRLDNPMARVTTTAER 222
Query: 241 SFLKTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDG 280
L L C +P+ + ND L L V+S DG
Sbjct: 223 GVLSLLQADCFSPIAVHAVYTANDK--SLRLHAKVFSRDG 260
>UniRef50_Q9Y9J0 Cluster: Probable porphobilinogen deaminase; n=1;
Aeropyrum pernix|Rep: Probable porphobilinogen deaminase
- Aeropyrum pernix
Length = 307
Score = 123 bits (296), Expect = 1e-26
Identities = 95/277 (34%), Positives = 139/277 (50%), Gaps = 11/277 (3%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYP-EKEFKIVTMTTLGDRVLDQPLPKIGEKSLF 65
+ + V +R S L+L+Q ++ L R +++V + + GD D+PL IG +F
Sbjct: 1 MRVRVAARGSRLSLLQVEQALEELSRYAGVSMHWEVVRVKSAGDVWSDRPLESIGVVGVF 60
Query: 66 TKDLEDALMSKNVDFVVHSLKDLPTTLPDG-LVIGAVFEREDPRDALVLNEKFKEYSLST 124
T++++ A+ S D VHSLKD+PT+ G L I + R RDAL+ + +
Sbjct: 61 TREVDRAVASGAADIAVHSLKDMPTSGYGGPLKIVYIASRPSARDALISRQ--GPGRVED 118
Query: 125 LPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSR 184
L GS +GTSS RR A P+++V ++RGNL+TRLRKL +G Y +I + AGL R
Sbjct: 119 LEPGSTLGTSSARRRALSLHYNPRIRVENLRGNLDTRLRKL--REGLYDAIIASEAGLIR 176
Query: 185 MGWGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLK 244
+G + + P S A GQG +AV R V ML + P + AER L+
Sbjct: 177 LGVDVEYTPLDP-SYFPPAPGQGFVAVVARV-GSNVEKMLRDLDKPPWWHVAWAERGVLE 234
Query: 245 TLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGS 281
GC PV + V +T A S DGS
Sbjct: 235 GARAGCRTPVAAYAEPLGRSMV---RVTAAALSPDGS 268
>UniRef50_Q976H1 Cluster: Probable porphobilinogen deaminase; n=3;
Sulfolobus|Rep: Probable porphobilinogen deaminase -
Sulfolobus tokodaii
Length = 294
Score = 120 bits (290), Expect = 5e-26
Identities = 79/250 (31%), Positives = 131/250 (52%), Gaps = 11/250 (4%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ I + +R S+L+ +Q V + L + E EF + + T D ++PL K+G K +F
Sbjct: 1 MRIRIAARGSKLSRIQVMMVENYLHKLGIETEF--IEIKTKADLFQNEPLSKLG-KGVFE 57
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
K++ A++ D VHS+KD+ T + + L I AV R+ P D L+ + +L L
Sbjct: 58 KEVNQAVLDNKADVAVHSMKDILTEISENLEIYAVLPRDPPFDILISRK-----NLFNLE 112
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
S+IGTSS+RR L L + D+RGN++TRL+K +G+Y +I+A A + R+
Sbjct: 113 PNSIIGTSSIRRKNFLTFYRNDLNIKDLRGNIDTRLKKY--FEGQYDGIIIAEASIYRLK 170
Query: 187 WGNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTL 246
+ ++ P QG + V R +E + + N +T +AER L +
Sbjct: 171 EQVQYYRLDP-HLFTPEANQGIIVVIGRKKDETIKKIFNEINDKDTLEIAIAERKALSIV 229
Query: 247 GGGCSAPVGI 256
GGGC +P+G+
Sbjct: 230 GGGCHSPIGV 239
>UniRef50_Q6MHU0 Cluster: Hydroxymethylbilane synthase; n=1;
Bdellovibrio bacteriovorus|Rep: Hydroxymethylbilane
synthase - Bdellovibrio bacteriovorus
Length = 502
Score = 119 bits (286), Expect = 2e-25
Identities = 98/299 (32%), Positives = 142/299 (47%), Gaps = 29/299 (9%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
+ + + +RKS+LA +Q V D+LK P+ E +LGD+ L PL KI EK +FT
Sbjct: 1 MRLRISARKSDLARLQAYMVGDALKEKNPQIEIDYRFRESLGDKNLTDPLWKIPEKGVFT 60
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
+D L+ D VVHS KDLPT VI A R D RD L++ + + + T
Sbjct: 61 EDFFGELLRDETDLVVHSWKDLPTEHKSETVIAATLPRADQRDLLLVKKSHFD-KIKTSK 119
Query: 127 SGSVIGTSSLRRTAQLNGNYPQ--------LKVVDVRGNLNTRLRKLDDEDGKYSDLILA 178
+ V +SS RR L G + + +K VRGN+ TR+RKL E + LI+A
Sbjct: 120 TLKVF-SSSPRREYNLTGFFKEHLPFGLQDVKFESVRGNMLTRVRKL-IESPETDGLIVA 177
Query: 179 SAGLSRM----------------GWGNRMS-KVLPCSEMLYAVGQGALAVECRADNEEVL 221
A R+ + N ++ VLP S A QGALAVE +++
Sbjct: 178 KAAFDRLFSATLPEFLEGQQQLRQYFNELNWVVLPLSVNPNAAAQGALAVEVLKSRQDLQ 237
Query: 222 AMLAPFNHPETYCRVLAERSFLKTLGGGCSAPVGISTKLKQNDNVYKLT-LTGAVWSLD 279
+L +H +T+ ER L + GGGC +G++ + + L LT A LD
Sbjct: 238 DLLQSIHHADTFHCSQKERDVLSSFGGGCHQKIGVAVLARPYGQITLLKGLTDAGQVLD 296
>UniRef50_Q9HMY5 Cluster: Probable porphobilinogen deaminase; n=1;
Halobacterium salinarum|Rep: Probable porphobilinogen
deaminase - Halobacterium salinarium (Halobacterium
halobium)
Length = 396
Score = 118 bits (285), Expect = 2e-25
Identities = 66/157 (42%), Positives = 96/157 (61%), Gaps = 5/157 (3%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I + +R S+LAL Q V+D+L+ + E +V + T GDRV D + +G+ F +
Sbjct: 6 IRLATRGSDLALRQAGEVVDTLEDRRHDVE--LVEVETEGDRVTDALISDLGKTGAFVRA 63
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
L+ +M VD VHS+KD+PT +P+ LV+ AV RE+P D LV + L LP+G
Sbjct: 64 LDQEVMEGTVDAAVHSMKDVPTEVPEDLVVAAVPHRENPADVLVTPD---GTDLEDLPAG 120
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKL 165
SV+GT+SLRR AQ+ + P L V +RGN+ TR+ KL
Sbjct: 121 SVVGTASLRRGAQVQAHRPGLDVEPIRGNVGTRVEKL 157
Score = 70.5 bits (165), Expect = 7e-11
Identities = 49/157 (31%), Positives = 72/157 (45%), Gaps = 5/157 (3%)
Query: 167 DEDGKYSDLILASAGLSRMGWGNRMS-KVLPCSEMLYAVGQGALAVECRADNEEVLAMLA 225
D D +Y L++A GL R G + + + L + A GQGAL V R D++ V +
Sbjct: 244 DPDTEYDALVMARVGLERTGLLHHVGIEELSTGTHVPATGQGALCVTARRDSDVVDTLRD 303
Query: 226 PFNHPETYCRVLAERSFLKTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLE 285
H T V AER L+ LGGGC AP+G+ L Q D + V+S DGS ++
Sbjct: 304 ALEHVRTRVEVTAERVVLEELGGGCIAPIGVHA-LVQGDTIRTAV---QVFSQDGSEQVG 359
Query: 286 ETLDQTFGQIRKTVKHKLSPTEEASSKKIKTDKTVEA 322
ET + Q + + + + + D EA
Sbjct: 360 ETRELDAEQYATDARELAADLRDRGAADLIEDARTEA 396
>UniRef50_Q1XAN5 Cluster: Putative porphobilinogen deaminase; n=2;
Actinomycetales|Rep: Putative porphobilinogen deaminase
- Streptomyces nodosus subsp. asukaensis
Length = 167
Score = 116 bits (279), Expect = 1e-24
Identities = 68/158 (43%), Positives = 98/158 (62%), Gaps = 9/158 (5%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
+ +G+R+S+LA+ Q+ V D++ + ++V +TT GD + + L +IG +F
Sbjct: 15 LRLGTRRSKLAMAQSGMVADAVSE-VTGRAVELVEVTTYGD-ISREHLAQIGGTGVFVAA 72
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
L DAL+ VDF VHSLKDLPT P+GLV+ AV REDPRD LV + + LPSG
Sbjct: 73 LRDALLRGEVDFAVHSLKDLPTAQPEGLVLAAVPVREDPRDVLVARDGL---TFEQLPSG 129
Query: 129 SVIGTSSLRRTAQLNG---NYP-QLKVVDVRGNLNTRL 162
+ IGT S RR AQLN N+ ++ V +RGN++TR+
Sbjct: 130 ARIGTGSPRRMAQLNAYARNHGLDIETVPIRGNVDTRI 167
>UniRef50_Q9PK95 Cluster: Probable porphobilinogen deaminase; n=7;
Chlamydiaceae|Rep: Probable porphobilinogen deaminase -
Chlamydia muridarum
Length = 242
Score = 113 bits (272), Expect = 8e-24
Identities = 75/206 (36%), Positives = 108/206 (52%), Gaps = 10/206 (4%)
Query: 6 KLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLF 65
K+ + + SRKS LA++Q + + L+ +P +++T TT GD PL + F
Sbjct: 18 KIPLRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQGDLDQHTPLHSVENTGFF 77
Query: 66 TKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTL 125
T D++ + S D +HS KDLP P VI A+ DPRD LV EK Y L
Sbjct: 78 TDDIDFLVQSGKCDLAIHSAKDLPEK-PKARVI-AITASIDPRDILVFQEK---YLLQPF 132
Query: 126 PSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRM 185
PS IG SS RR A ++ YP + D+RG + TRL LD + K+ +++A+A +SR+
Sbjct: 133 PSRLRIGCSSDRRRALISSLYPSAVITDIRGTIQTRLALLDQQ--KFDAIVMANAAVSRL 190
Query: 186 GWGNRMSKVLPCSEMLYAVGQGALAV 211
G + VLP Y QG LA+
Sbjct: 191 GLRLPCTVVLPPP---YHPFQGRLAI 213
>UniRef50_Q7RNI8 Cluster: Porphobilinogen deaminase, putative; n=5;
Plasmodium|Rep: Porphobilinogen deaminase, putative -
Plasmodium yoelii yoelii
Length = 583
Score = 113 bits (271), Expect = 1e-23
Identities = 83/295 (28%), Positives = 150/295 (50%), Gaps = 42/295 (14%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPE--KEFKIVT--MTTLGDRVLDQPLPKIGEKSL 64
I +G+R S LA+ Q+ V L + + + ++ + T GD++LD+ + G K +
Sbjct: 73 IIIGTRNSPLAIKQSEKVKKKLLTYFKKINENINVILKPIKTTGDKILDKTVGSFGGKGI 132
Query: 65 FTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDAL--VLNEKFKEYSL 122
FTK+L++ L+ NVD VHSLKD+PT LPD + + +R+ DA + + ++ +L
Sbjct: 133 FTKELDEELIKNNVDICVHSLKDIPTVLPDNIHLSCFLKRDTINDAFLSIKYKNLRDINL 192
Query: 123 ST------LPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLI 176
S+ + I TSSLRRT+Q+ Y LK+ +RGN+NTR+ KL + + +I
Sbjct: 193 SSHVIDKEIDLPRTIATSSLRRTSQIRYKYKNLKLKFIRGNINTRIAKL--FNNSFDSII 250
Query: 177 LASAGLSRMGWGNRMSKVLP--CSEMLYAVGQGALAVE--------------CRADNEEV 220
+A GL R+ + +++ + Y + ++++ C A + +
Sbjct: 251 IAFCGLERLVSKKILRQIMKNNIKDKSYIINYKNISIDLRHLNIQKLNTNIMCPALCQGI 310
Query: 221 LAMLAPFNHPE----------TYCRVLA--ERSFLKTLGGGCSAPVGISTKLKQN 263
+ + + N+PE +++A ER+FL+ + G C+ P+G TK +N
Sbjct: 311 IGVTSNKNNPEISQILKNINNEKSQIMANIERAFLQKIDGSCTMPIGGYTKFSKN 365
>UniRef50_Q5UY52 Cluster: Porphobilinogen deaminase; n=3;
Halobacteriaceae|Rep: Porphobilinogen deaminase -
Haloarcula marismortui (Halobacterium marismortui)
Length = 389
Score = 106 bits (255), Expect = 9e-22
Identities = 62/158 (39%), Positives = 92/158 (58%), Gaps = 5/158 (3%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
++ + +R S+LAL Q V DSL E +V + T GD++ D+ + ++G+ F +
Sbjct: 7 TLQLATRGSDLALRQAATVRDSLSSRRLAVE--LVEVETTGDQIRDELIHRLGKTGAFVR 64
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
L++ ++ +D VHS+KD+PT P+ LV+ AV ER D LV + SL LP
Sbjct: 65 SLDEKVLDGELDAAVHSMKDMPTERPERLVVAAVPERAAAEDVLVTPD---GRSLEELPE 121
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKL 165
G+ +GTSSLRR AQL L V +RGN++TRL KL
Sbjct: 122 GATVGTSSLRRKAQLLAERDDLTVEPLRGNVDTRLAKL 159
Score = 60.1 bits (139), Expect = 1e-07
Identities = 37/97 (38%), Positives = 53/97 (54%), Gaps = 4/97 (4%)
Query: 167 DEDGKYSDLILASAGLSRMGWGNR--MSKVLPCSEMLYAVGQGALAVECRADNEEVLAML 224
D D +Y ++LA AGL R G MS + P + + A GQGALAV D + L +
Sbjct: 222 DPDVEYDAIVLAKAGLHRAGLTRYVGMSDLDP-DQFVPAPGQGALAVTA-VDGDLALDIK 279
Query: 225 APFNHPETYCRVLAERSFLKTLGGGCSAPVGISTKLK 261
+ P+T ER+ L+ LGGGC AP+G+ +L+
Sbjct: 280 DRLDDPQTRIETTVERTILEELGGGCVAPIGVHAQLE 316
>UniRef50_A7D1I3 Cluster: Porphobilinogen deaminase; n=1; Halorubrum
lacusprofundi ATCC 49239|Rep: Porphobilinogen deaminase
- Halorubrum lacusprofundi ATCC 49239
Length = 415
Score = 106 bits (255), Expect = 9e-22
Identities = 65/178 (36%), Positives = 100/178 (56%), Gaps = 7/178 (3%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
++ + +R S+LAL Q V D+L + E + V T GD++ D+ + ++G+ F +
Sbjct: 34 TLRLATRGSDLALRQAGTVRDALSSRRRDVELRRVE--TRGDQIPDEMIHRLGKTGAFVR 91
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
L++ ++ + D VHSLKD+PT D +VI V ER D LV + + LPS
Sbjct: 92 ALDEEVLGGDADLAVHSLKDVPTEGMDDMVIAGVPERAPSGDVLVHPDGL---GIEDLPS 148
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKL--DDEDGKYSDLILASAGLS 183
GSV+GT SLRRTAQ+ P L V +RGN++TR+ KL D ++ ++AS S
Sbjct: 149 GSVVGTGSLRRTAQIKAARPDLVVEPLRGNVDTRVEKLLAPDLQAEHERRLIASGEAS 206
Score = 63.3 bits (147), Expect = 1e-08
Identities = 45/128 (35%), Positives = 67/128 (52%), Gaps = 9/128 (7%)
Query: 163 RKLDDEDGKYSDLILASAGLSRMGWGNRMSKV-LPCSEMLYAVGQGALAVECRADNEEVL 221
RK++ E Y ++LA AGL R + LP E + A GQGA+AV D + +
Sbjct: 253 RKVETE---YDAIVLAEAGLRRSELFYEVPTTRLPREEFVPAAGQGAIAVTA-TDPDVIE 308
Query: 222 AMLAPFNHPETYCRVLAERSFLKTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGS 281
+ + +HP T V ER+ L L GGC AP+G+S L Q ++V+ V S DG+
Sbjct: 309 DVRSAVDHPRTRVAVTVERTILGELNGGCVAPIGVSA-LVQGEHVHTRV---RVLSTDGT 364
Query: 282 TKLEETLD 289
++ +T D
Sbjct: 365 EEVADTRD 372
>UniRef50_Q6MEK3 Cluster: Putative Porphobilinogen deaminase; n=1;
Candidatus Protochlamydia amoebophila UWE25|Rep:
Putative Porphobilinogen deaminase - Protochlamydia
amoebophila (strain UWE25)
Length = 233
Score = 104 bits (250), Expect = 4e-21
Identities = 70/218 (32%), Positives = 113/218 (51%), Gaps = 8/218 (3%)
Query: 8 SIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTK 67
SI VG+R S L+ Q ++ +L+ YP EF I T+GD L + + + FTK
Sbjct: 17 SISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLDQKTSLRDLDKTNFFTK 76
Query: 68 DLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPS 127
++++A++ K +HS KDLP +PDGL + + + D D LVL + +L TLP
Sbjct: 77 EIDEAILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVLVLRD---GETLQTLPP 133
Query: 128 GSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGW 187
S I TSS+RR + +D+RG ++ RL L+ + +++A A L R+G
Sbjct: 134 HSRIATSSIRRENIVKLLRNDFIFLDLRGTIHQRLALLEKKQA--DGVVVAEAALIRLGL 191
Query: 188 GNRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLA 225
+ LP + + GQG LA+ R D+ ++ + A
Sbjct: 192 THLNRIRLPGTTV---EGQGQLAIIARKDDAKMQTLFA 226
>UniRef50_Q6Q923 Cluster: Predicted porphobilinogen deaminase; n=2;
environmental samples|Rep: Predicted porphobilinogen
deaminase - uncultured marine gamma proteobacterium
EBAC20E09
Length = 291
Score = 96.3 bits (229), Expect = 1e-18
Identities = 77/278 (27%), Positives = 133/278 (47%), Gaps = 22/278 (7%)
Query: 7 LSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFT 66
++I + SR S+LAL Q ++ + + ++KI+ + T GD + + +K+ F
Sbjct: 1 MTIKIASRSSKLALAQ----VEEFVKKFGISDYKIIKVKTEGD-IKSANGETLFDKAHFV 55
Query: 67 KDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLP 126
D++ L++ D VHS KD P GL + + +D L+ E+ K
Sbjct: 56 SDVQKCLLNGEADIAVHSAKDTPAGETTGL-LRYFLPSQSNQDVLIFREEDK------FN 108
Query: 127 SGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMG 186
S +GTSSLRR Q + + +V++ GN++TRL KL G+Y +ILA AGL+R+
Sbjct: 109 SEMKLGTSSLRRQLQAKHHLNAINIVNLSGNVDTRLEKL--SQGEYDCIILAKAGLARLK 166
Query: 187 WGNRMS-KVLPCSEMLYAVGQGALAVECRADNEEVL--AMLAPFNHPETYC--RVLAERS 241
N + +V+ S A GQG L +E D + +L + + ERS
Sbjct: 167 LLNELQYEVMDWST---ASGQGFLCIEVLNDPSADIYNFLLKSIREIDLNLGKNISTERS 223
Query: 242 FLKTLGGGCSAPVGISTKLKQNDNVYKLTLTGAVWSLD 279
L+ + GC++ + I T+ +L G ++ ++
Sbjct: 224 ILEAINAGCNSAISIQTQSNLESENSQLIHLGEIYGVE 261
>UniRef50_Q1FIV1 Cluster: Porphobilinogen deaminase; n=1;
Clostridium phytofermentans ISDg|Rep: Porphobilinogen
deaminase - Clostridium phytofermentans ISDg
Length = 159
Score = 86.2 bits (204), Expect = 1e-15
Identities = 51/109 (46%), Positives = 68/109 (62%), Gaps = 6/109 (5%)
Query: 147 PQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNRMSKVLPCSEMLYAVGQ 206
P VRGN+ TRL KLD G+Y+ LILA+AGL R+G +R+S EM+ A GQ
Sbjct: 3 PSAGTTGVRGNVITRLDKLDR--GEYTSLILAAAGLQRVGLPHRISHYFSVEEMIPAAGQ 60
Query: 207 GALAVECRAD-NEEVLAMLAPFNHPETYCRVLAERSFLKTLGGGCSAPV 254
G L+++ R D N + L + N TY LAERSF++TL GGCS+P+
Sbjct: 61 GILSIQARRDLNVDFLENIKDAN--TTYAS-LAERSFVRTLDGGCSSPI 106
>UniRef50_A5K0J5 Cluster: Porphobilinogen deaminase, putative; n=1;
Plasmodium vivax|Rep: Porphobilinogen deaminase,
putative - Plasmodium vivax
Length = 341
Score = 60.9 bits (141), Expect = 6e-08
Identities = 26/66 (39%), Positives = 42/66 (63%)
Query: 47 LGDRVLDQPLPKIGEKSLFTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFERED 106
+GD +LD+ + G K +FTK+L++ L+ KNV VHSLKD+P LP+ + + +R+
Sbjct: 1 MGDHILDKKVGLFGGKGIFTKELDEQLIKKNVHICVHSLKDVPMELPEHVQLSCFLKRDT 60
Query: 107 PRDALV 112
DA +
Sbjct: 61 INDAFL 66
Score = 55.2 bits (127), Expect = 3e-06
Identities = 27/55 (49%), Positives = 39/55 (70%), Gaps = 2/55 (3%)
Query: 131 IGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRM 185
IGTSSLRR++Q+ Y + V +VRGN+NTR+ KL +G+Y +I+A GL R+
Sbjct: 121 IGTSSLRRSSQIKYTYKNVAVKNVRGNINTRIAKLC--NGQYDAIIIAKCGLERL 173
>UniRef50_UPI0000D9FBB5 Cluster: PREDICTED: similar to lethal (3)
02640 CG9165-PA; n=1; Macaca mulatta|Rep: PREDICTED:
similar to lethal (3) 02640 CG9165-PA - Macaca mulatta
Length = 105
Score = 59.3 bits (137), Expect = 2e-07
Identities = 38/115 (33%), Positives = 60/115 (52%), Gaps = 17/115 (14%)
Query: 1 MDGETKLSIHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIG 60
M ++ ++ +GSR+S+LA +QT V D L+ E +K+V + +P+ G
Sbjct: 1 MSSDSNATLRIGSRRSDLARLQTLMVADRLE----EMGYKVVLVG----------MPETG 46
Query: 61 EKSLFTKDLEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNE 115
+FT L L+ +VD VVHS KDLP G + A R DPRD +++ +
Sbjct: 47 ---VFTTFLRQKLLDGSVDLVVHSWKDLPLAEEAGTTVAATLPRADPRDLIIIRK 98
>UniRef50_Q2A077 Cluster: Methyltransferase/helicase protein; n=1;
Grapevine leafroll associated virus 9|Rep:
Methyltransferase/helicase protein - Grapevine leafroll
associated virus 9
Length = 2045
Score = 37.1 bits (82), Expect = 0.83
Identities = 23/68 (33%), Positives = 38/68 (55%), Gaps = 5/68 (7%)
Query: 297 KTVKHKLSPTEE--ASSKKIKTDKTVEADNEIAVLNRRITDKTGDLGCEDLAPNVADRRC 354
K +K KL P E A + + + TVEADN ++V + ++D + + E+L P + +C
Sbjct: 1291 KKMKAKLEPVSESDAEDSESECEPTVEADN-VSVADT-VSDSS-EQSMEELMPEIKHLKC 1347
Query: 355 FCGLTTNV 362
CG+ NV
Sbjct: 1348 DCGVDINV 1355
>UniRef50_Q65PS9 Cluster: Lj965 prophage protein; n=2; root|Rep:
Lj965 prophage protein - Lactobacillus johnsonii
Length = 1624
Score = 36.7 bits (81), Expect = 1.1
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 3/110 (2%)
Query: 289 DQTFGQIRKTVKHKLSPTEEASSKKIKTDKTVEADNEIAVLNRRITDKTGDLGCEDLAPN 348
D T +I+K V+ ++A KK D +AD +IA LN I ++ G L N
Sbjct: 417 DLTPDEIKKQVQEAQDGLKDA--KKEIADNLAKADKDIAELNESINNQKGSLDGLSTTVN 474
Query: 349 VADRRCFCGLTTNVNMPIDVVIKCDNLGRDLANSLIDKGALEVMKISHDI 398
+T V+ I V + N+ L N I +G ++ KI+ D+
Sbjct: 475 TVVIPKVTDVTNQVSDAIKKVNEQKNIVTGLQNQAIQQGK-DISKITSDV 523
>UniRef50_Q7MQW8 Cluster: Putative uncharacterized protein; n=1;
Wolinella succinogenes|Rep: Putative uncharacterized
protein - Wolinella succinogenes
Length = 666
Score = 35.9 bits (79), Expect = 1.9
Identities = 21/78 (26%), Positives = 40/78 (51%)
Query: 263 NDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTEEASSKKIKTDKTVEA 322
N + K TLTG + SLD + L +++T + + + + E + I ++ + A
Sbjct: 27 NTLLNKTTLTGKISSLDIAENLFAYMEETQQKFSQLQERLIDTLIEQNFLTILSEAELNA 86
Query: 323 DNEIAVLNRRITDKTGDL 340
+ I VLNR + ++T D+
Sbjct: 87 QSNIDVLNRNLFERTADI 104
>UniRef50_A5FPM5 Cluster: Phospho-2-dehydro-3-deoxyheptonate
aldolase; n=55; cellular organisms|Rep:
Phospho-2-dehydro-3-deoxyheptonate aldolase -
Dehalococcoides sp. BAV1
Length = 340
Score = 35.9 bits (79), Expect = 1.9
Identities = 19/58 (32%), Positives = 28/58 (48%)
Query: 190 RMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLG 247
R V+P S A G L VE +D L+ A +PE +C+++ E +L LG
Sbjct: 277 RRDYVIPLSRAAIATGADGLIVEVHSDPPSALSDGAQSLYPEQFCQLVKEVEYLNMLG 334
>UniRef50_A3M0A2 Cluster: Predicted protein; n=1; Pichia
stipitis|Rep: Predicted protein - Pichia stipitis
(Yeast)
Length = 889
Score = 35.1 bits (77), Expect = 3.4
Identities = 31/120 (25%), Positives = 55/120 (45%), Gaps = 8/120 (6%)
Query: 284 LEETLDQTFGQIRKTVKHKLSPTEEASSKKIKTDKTVEADNEIAVLNRRITDKTGDLGCE 343
L+E LD + K V+H S EE S K + KTVE EI L++ + + + E
Sbjct: 261 LQEQLDSVL-DLEKVVEHLTSQNEELSQKVVNLTKTVEDLTEIHELDKSLEENQKHVE-E 318
Query: 344 DLAPNVADRRCFCGLTTNVNMPIDVVIKCDNLGRDLANSLIDKGALEVMKISHDIIRSSI 403
+L ++A L+ V V+ +N + + + L ++EV + D +R+ +
Sbjct: 319 ELRISLAK------LSDVVRQDKGVIQDLENKNKWMEDKLNQLKSIEVFETGSDDLRNEL 372
>UniRef50_Q1Q6C1 Cluster: Putative uncharacterized protein; n=1;
Candidatus Kuenenia stuttgartiensis|Rep: Putative
uncharacterized protein - Candidatus Kuenenia
stuttgartiensis
Length = 146
Score = 34.7 bits (76), Expect = 4.4
Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 1/71 (1%)
Query: 302 KLSPTEEASSKKIKTDKTVEADNEIAVLNRRITDKTGDLGCEDLAPNVADRRCFCGLTTN 361
KL T E + +KT E DNE+A++ + + D + + V D F G
Sbjct: 58 KLKKTREEYERLSLPEKTREIDNELAIVEEYLPKQLSDEDVQKIVDEVVDENKFTGKEFG 117
Query: 362 VNMPIDVVIKC 372
V M + ++ KC
Sbjct: 118 VAMKL-IMNKC 127
>UniRef50_A6GK56 Cluster: Putative uncharacterized protein; n=1;
Plesiocystis pacifica SIR-1|Rep: Putative
uncharacterized protein - Plesiocystis pacifica SIR-1
Length = 359
Score = 34.7 bits (76), Expect = 4.4
Identities = 28/103 (27%), Positives = 42/103 (40%), Gaps = 4/103 (3%)
Query: 250 CSAPVGISTKL-KQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTEE 308
C PVG L + ND V + T T + + + EE+ + T T + T E
Sbjct: 17 CLGPVGCGDDLVESNDEVGEDTDTETESTEESTESTEESTESTEESTESTESE--TDTTE 74
Query: 309 ASSKKIKTDKTVEADNEIAVLNRRITDKTGDLGCEDLAPNVAD 351
+ +TD T E D + TD TG+ G ED + +
Sbjct: 75 TETDTTETD-TTETDTTTEETDTGETDTTGETGTEDTTEDTTE 116
>UniRef50_UPI0000F1DC15 Cluster: PREDICTED: hypothetical protein;
n=4; Eukaryota|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 343
Score = 34.3 bits (75), Expect = 5.9
Identities = 21/81 (25%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 257 STKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTEEASSKKIKT 316
+TK+K+ K T+ + + K +T +T +IRKT K K ++ + K KT
Sbjct: 191 TTKIKKTAKTMKKTMKKNTKTTKKTMKTTKTKKKTT-KIRKTAKTKKKTMKKTTKTKKKT 249
Query: 317 DKTVEADNEIAVLNRRITDKT 337
KT++ ++ + T++T
Sbjct: 250 TKTIKNTTKVIKKTTKTTERT 270
>UniRef50_UPI0000D56AE8 Cluster: PREDICTED: similar to CG12950-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG12950-PA - Tribolium castaneum
Length = 773
Score = 34.3 bits (75), Expect = 5.9
Identities = 39/150 (26%), Positives = 67/150 (44%), Gaps = 12/150 (8%)
Query: 122 LSTLPSGSVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAG 181
L+ S I S +RT L NYP + + L+T + K + D + + A+
Sbjct: 314 LTCKASNQRIPFSEQQRTWMLRVNYPPKVTLTLGHGLDTSVIK-EGSDVYFECHLTANPW 372
Query: 182 LSRMGW---GNRM-----SKVLPCSE--MLYAVGQGALAVEC-RADNEEVLAMLAPFNHP 230
+ R+ W GNR+ + V+ ++ +L +V + + C A N+E + PF+
Sbjct: 373 VHRVWWLRDGNRLLSNATAGVIVSNQTLVLQSVSRASSGRYCCEATNKEGTSTSPPFHLR 432
Query: 231 ETYCRVLAERSFLKTLGGGCSAPVGISTKL 260
+ V AERS K LG P+ + K+
Sbjct: 433 VKFPPVCAERSGRKVLGAAKDEPLKVECKV 462
>UniRef50_Q2IE64 Cluster: Putative uncharacterized protein; n=1;
Anaeromyxobacter dehalogenans 2CP-C|Rep: Putative
uncharacterized protein - Anaeromyxobacter dehalogenans
(strain 2CP-C)
Length = 323
Score = 34.3 bits (75), Expect = 5.9
Identities = 22/71 (30%), Positives = 35/71 (49%), Gaps = 4/71 (5%)
Query: 186 GWGNRMSKVLPCSEMLYAVGQGALAVECRADNEE---VLAMLAPFNHPETYCRVLAERSF 242
GWG R ++LP +E L A G A+ V+ A + +M+ + ET R + R+
Sbjct: 91 GWGGRAGQLLPLAEALAAAGCAAVTVDAPAHGASRGCIASMIHFADAAETVARAVGARAA 150
Query: 243 L-KTLGGGCSA 252
+ +LGG A
Sbjct: 151 VGHSLGGAAVA 161
>UniRef50_Q6BMT0 Cluster: Similar to tr|Q9C3Y7 Candida albicans
Lysine/glutamic acid-rich protein; n=1; Debaryomyces
hansenii|Rep: Similar to tr|Q9C3Y7 Candida albicans
Lysine/glutamic acid-rich protein - Debaryomyces
hansenii (Yeast) (Torulaspora hansenii)
Length = 1085
Score = 34.3 bits (75), Expect = 5.9
Identities = 24/109 (22%), Positives = 53/109 (48%), Gaps = 1/109 (0%)
Query: 75 SKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSGSVIGTS 134
SK + + L+DL + + + A FE+E ++ NE +KE + + S +
Sbjct: 394 SKFTTDIGNKLQDLKKKMKNSDLTAANFEKETRKEIDTANEDYKERETTAVEKHSKDKDT 453
Query: 135 SLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLS 183
++ +L G Q ++ D + N T +++++ + ++L A++ LS
Sbjct: 454 IIKNHEELEGTKKQ-ELEDAKANQETTTQEIEELHERKTELDNANSELS 501
>UniRef50_Q2S670 Cluster: Methyl-accepting chemotaxis transducer;
n=3; Salinibacter ruber DSM 13855|Rep: Methyl-accepting
chemotaxis transducer - Salinibacter ruber (strain DSM
13855)
Length = 514
Score = 33.9 bits (74), Expect = 7.8
Identities = 23/66 (34%), Positives = 33/66 (50%), Gaps = 9/66 (13%)
Query: 255 GISTKLKQNDNVYKLTLT--------GAVWSL-DGSTKLEETLDQTFGQIRKTVKHKLSP 305
G+ T LK D + + LT GA+ L +G + ET+ Q G++R+ K S
Sbjct: 155 GVDTMLKATDRLAEGDLTTRLPEGQGGAIGRLFEGFNEAAETMGQAMGEVRRATKSVASA 214
Query: 306 TEEASS 311
TEE SS
Sbjct: 215 TEEISS 220
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.315 0.134 0.378
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 436,957,181
Number of Sequences: 1657284
Number of extensions: 18368806
Number of successful extensions: 48672
Number of sequences better than 10.0: 141
Number of HSP's better than 10.0 without gapping: 131
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 48179
Number of HSP's gapped (non-prelim): 179
length of query: 407
length of database: 575,637,011
effective HSP length: 102
effective length of query: 305
effective length of database: 406,594,043
effective search space: 124011183115
effective search space used: 124011183115
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 74 (33.9 bits)
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