Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000119-TA|BGIBMGA000119-PA|IPR000860|Porphobilinogen
deaminase
(407 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X04217-1|CAA27801.1| 344|Homo sapiens protein ( Human mRNA for ... 315 2e-85
BC019323-1|AAH19323.1| 361|Homo sapiens hydroxymethylbilane syn... 315 2e-85
BC008149-1|AAH08149.1| 361|Homo sapiens hydroxymethylbilane syn... 315 2e-85
BC000520-1|AAH00520.1| 361|Homo sapiens hydroxymethylbilane syn... 315 2e-85
M95623-2|AAA60030.1| 344|Homo sapiens hydroxymethylbilane synth... 314 3e-85
M95623-1|AAA60029.1| 361|Homo sapiens hydroxymethylbilane synth... 314 3e-85
X04808-1|CAA28499.1| 361|Homo sapiens protein ( Human mRNA for ... 314 5e-85
AB162702-1|BAD36778.1| 157|Homo sapiens porphobilinogen deamina... 99 3e-20
DQ915447-1|ABI36594.1| 87|Homo sapiens hydroxymethylbilane syn... 83 1e-15
S60381-1|AAC60602.1| 38|Homo sapiens porphobilinogen deaminase... 53 2e-06
>X04217-1|CAA27801.1| 344|Homo sapiens protein ( Human mRNA for
porphobilinogen deaminase (PBG-D, EC 4.3.1.8). ).
Length = 344
Score = 315 bits (774), Expect = 2e-85
Identities = 162/326 (49%), Positives = 221/326 (67%), Gaps = 9/326 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I VG+RKS+LA +QT+ V+ +LK +YP +F+I+ M+T GD++LD L KIGEKSLFTK+
Sbjct: 4 IRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKE 63
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE AL VD VVHSLKDLPT LP G IGA+ +RE+P DA+V + KF +L TLP
Sbjct: 64 LEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEK 123
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
SV+GTSSLRR AQL +P L+ +RGNLNTRLRKLD++ ++S +ILA+AGL RMGW
Sbjct: 124 SVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQ-EFSAIILATAGLQRMGWH 182
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
NR+ ++L E +YAVGQGAL VE RA ++++L ++ + PET R +AER+FL+ L G
Sbjct: 183 NRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEG 242
Query: 249 GCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTEE 308
GCS PV + T +K +L LTG VWSLDGS ++ET+ T I +H+ P ++
Sbjct: 243 GCSVPVAVHTAMKDG----QLYLTGGVWSLDGSDSIQETMQAT---IHVPAQHEDGPEDD 295
Query: 309 ASSKKIKTDKTVEADNEIAVLNRRIT 334
I T + + ++A N I+
Sbjct: 296 PQLVGI-TARNIPRGPQLAAQNLGIS 320
>BC019323-1|AAH19323.1| 361|Homo sapiens hydroxymethylbilane
synthase protein.
Length = 361
Score = 315 bits (774), Expect = 2e-85
Identities = 162/326 (49%), Positives = 221/326 (67%), Gaps = 9/326 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I VG+RKS+LA +QT+ V+ +LK +YP +F+I+ M+T GD++LD L KIGEKSLFTK+
Sbjct: 21 IRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKE 80
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE AL VD VVHSLKDLPT LP G IGA+ +RE+P DA+V + KF +L TLP
Sbjct: 81 LEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEK 140
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
SV+GTSSLRR AQL +P L+ +RGNLNTRLRKLD++ ++S +ILA+AGL RMGW
Sbjct: 141 SVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQ-EFSAIILATAGLQRMGWH 199
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
NR+ ++L E +YAVGQGAL VE RA ++++L ++ + PET R +AER+FL+ L G
Sbjct: 200 NRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEG 259
Query: 249 GCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTEE 308
GCS PV + T +K +L LTG VWSLDGS ++ET+ T I +H+ P ++
Sbjct: 260 GCSVPVAVHTAMKDG----QLYLTGGVWSLDGSDSIQETMQAT---IHVPAQHEDGPEDD 312
Query: 309 ASSKKIKTDKTVEADNEIAVLNRRIT 334
I T + + ++A N I+
Sbjct: 313 PQLVGI-TARNIPRGPQLAAQNLGIS 337
>BC008149-1|AAH08149.1| 361|Homo sapiens hydroxymethylbilane
synthase protein.
Length = 361
Score = 315 bits (774), Expect = 2e-85
Identities = 162/326 (49%), Positives = 221/326 (67%), Gaps = 9/326 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I VG+RKS+LA +QT+ V+ +LK +YP +F+I+ M+T GD++LD L KIGEKSLFTK+
Sbjct: 21 IRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKE 80
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE AL VD VVHSLKDLPT LP G IGA+ +RE+P DA+V + KF +L TLP
Sbjct: 81 LEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEK 140
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
SV+GTSSLRR AQL +P L+ +RGNLNTRLRKLD++ ++S +ILA+AGL RMGW
Sbjct: 141 SVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQ-EFSAIILATAGLQRMGWH 199
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
NR+ ++L E +YAVGQGAL VE RA ++++L ++ + PET R +AER+FL+ L G
Sbjct: 200 NRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEG 259
Query: 249 GCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTEE 308
GCS PV + T +K +L LTG VWSLDGS ++ET+ T I +H+ P ++
Sbjct: 260 GCSVPVAVHTAMKDG----QLYLTGGVWSLDGSDSIQETMQAT---IHVPAQHEDGPEDD 312
Query: 309 ASSKKIKTDKTVEADNEIAVLNRRIT 334
I T + + ++A N I+
Sbjct: 313 PQLVGI-TARNIPRGPQLAAQNLGIS 337
>BC000520-1|AAH00520.1| 361|Homo sapiens hydroxymethylbilane
synthase protein.
Length = 361
Score = 315 bits (774), Expect = 2e-85
Identities = 162/326 (49%), Positives = 221/326 (67%), Gaps = 9/326 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I VG+RKS+LA +QT+ V+ +LK +YP +F+I+ M+T GD++LD L KIGEKSLFTK+
Sbjct: 21 IRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKE 80
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE AL VD VVHSLKDLPT LP G IGA+ +RE+P DA+V + KF +L TLP
Sbjct: 81 LEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEK 140
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
SV+GTSSLRR AQL +P L+ +RGNLNTRLRKLD++ ++S +ILA+AGL RMGW
Sbjct: 141 SVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQ-EFSAIILATAGLQRMGWH 199
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
NR+ ++L E +YAVGQGAL VE RA ++++L ++ + PET R +AER+FL+ L G
Sbjct: 200 NRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEG 259
Query: 249 GCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTEE 308
GCS PV + T +K +L LTG VWSLDGS ++ET+ T I +H+ P ++
Sbjct: 260 GCSVPVAVHTAMKDG----QLYLTGGVWSLDGSDSIQETMQAT---IHVPAQHEDGPEDD 312
Query: 309 ASSKKIKTDKTVEADNEIAVLNRRIT 334
I T + + ++A N I+
Sbjct: 313 PQLVGI-TARNIPRGPQLAAQNLGIS 337
>M95623-2|AAA60030.1| 344|Homo sapiens hydroxymethylbilane synthase
protein.
Length = 344
Score = 314 bits (772), Expect = 3e-85
Identities = 161/326 (49%), Positives = 221/326 (67%), Gaps = 9/326 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I VG+RKS+LA +QT+ V+ +LK +YP +F+I+ M+T GD++LD L KIGEKSLFTK+
Sbjct: 4 IRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKE 63
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE AL VD VVHSLKDLPT LP G IGA+ +RE+P DA+V + KF +L TLP
Sbjct: 64 LEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEK 123
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
SV+GTSSLRR AQL +P L+ +RGNLNTRLRK+D++ ++S +ILA+AGL RMGW
Sbjct: 124 SVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKMDEQQ-EFSAIILATAGLQRMGWH 182
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
NR+ ++L E +YAVGQGAL VE RA ++++L ++ + PET R +AER+FL+ L G
Sbjct: 183 NRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEG 242
Query: 249 GCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTEE 308
GCS PV + T +K +L LTG VWSLDGS ++ET+ T I +H+ P ++
Sbjct: 243 GCSVPVAVHTAMKDG----QLYLTGGVWSLDGSDSIQETMQAT---IHVPAQHEDGPEDD 295
Query: 309 ASSKKIKTDKTVEADNEIAVLNRRIT 334
I T + + ++A N I+
Sbjct: 296 PQLVGI-TARNIPRGPQLAAQNLGIS 320
>M95623-1|AAA60029.1| 361|Homo sapiens hydroxymethylbilane synthase
protein.
Length = 361
Score = 314 bits (772), Expect = 3e-85
Identities = 161/326 (49%), Positives = 221/326 (67%), Gaps = 9/326 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I VG+RKS+LA +QT+ V+ +LK +YP +F+I+ M+T GD++LD L KIGEKSLFTK+
Sbjct: 21 IRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKE 80
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE AL VD VVHSLKDLPT LP G IGA+ +RE+P DA+V + KF +L TLP
Sbjct: 81 LEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEK 140
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
SV+GTSSLRR AQL +P L+ +RGNLNTRLRK+D++ ++S +ILA+AGL RMGW
Sbjct: 141 SVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKMDEQQ-EFSAIILATAGLQRMGWH 199
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
NR+ ++L E +YAVGQGAL VE RA ++++L ++ + PET R +AER+FL+ L G
Sbjct: 200 NRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEG 259
Query: 249 GCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTEE 308
GCS PV + T +K +L LTG VWSLDGS ++ET+ T I +H+ P ++
Sbjct: 260 GCSVPVAVHTAMKDG----QLYLTGGVWSLDGSDSIQETMQAT---IHVPAQHEDGPEDD 312
Query: 309 ASSKKIKTDKTVEADNEIAVLNRRIT 334
I T + + ++A N I+
Sbjct: 313 PQLVGI-TARNIPRGPQLAAQNLGIS 337
>X04808-1|CAA28499.1| 361|Homo sapiens protein ( Human mRNA for
non-erythropoietic porphobilinogen deaminase
(hydroxymethylbilane synthase; EC4.3.1.8). ).
Length = 361
Score = 314 bits (770), Expect = 5e-85
Identities = 161/326 (49%), Positives = 221/326 (67%), Gaps = 9/326 (2%)
Query: 9 IHVGSRKSELALVQTNFVIDSLKRNYPEKEFKIVTMTTLGDRVLDQPLPKIGEKSLFTKD 68
I VG+RKS+LA +QT+ V+ +LK +YP +F+I+ M+T GD++LD L KIGEKSLFTK+
Sbjct: 21 IRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKE 80
Query: 69 LEDALMSKNVDFVVHSLKDLPTTLPDGLVIGAVFEREDPRDALVLNEKFKEYSLSTLPSG 128
LE AL VD VVHSLKDLPT LP G IGA+ +RE+P DA+V + KF +L TLP
Sbjct: 81 LEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEK 140
Query: 129 SVIGTSSLRRTAQLNGNYPQLKVVDVRGNLNTRLRKLDDEDGKYSDLILASAGLSRMGWG 188
SV+GTSSLRR AQL +P L+ +RGNLNTRLRKLD++ ++S +ILA+AGL RMGW
Sbjct: 141 SVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQ-EFSAIILATAGLQRMGWH 199
Query: 189 NRMSKVLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGG 248
NR+ ++L + +YAVGQGAL VE RA ++++L ++ + PET R +AER+FL+ L G
Sbjct: 200 NRVGQILHPEKCMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEG 259
Query: 249 GCSAPVGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTEE 308
GCS PV + T +K +L LTG VWSLDGS ++ET+ T I +H+ P ++
Sbjct: 260 GCSVPVAVHTAMKDG----QLYLTGGVWSLDGSDSIQETMQAT---IHVPAQHEDGPEDD 312
Query: 309 ASSKKIKTDKTVEADNEIAVLNRRIT 334
I T + + ++A N I+
Sbjct: 313 PQLVGI-TARNIPRGPQLAAQNLGIS 337
>AB162702-1|BAD36778.1| 157|Homo sapiens porphobilinogen deaminase
protein.
Length = 157
Score = 98.7 bits (235), Expect = 3e-20
Identities = 55/141 (39%), Positives = 82/141 (58%), Gaps = 8/141 (5%)
Query: 194 VLPCSEMLYAVGQGALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGGCSAP 253
+L E +YAVGQGAL VE RA ++++L ++ + PET R +AER+FL+ L GGCS P
Sbjct: 1 ILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVP 60
Query: 254 VGISTKLKQNDNVYKLTLTGAVWSLDGSTKLEETLDQTFGQIRKTVKHKLSPTEEASSKK 313
V + T +K +L LTG VWSLDGS ++ET+ T I +H+ P ++
Sbjct: 61 VAVHTAMKDG----QLYLTGGVWSLDGSDSIQETMQAT---IHVPAQHEDGPEDDPQLVG 113
Query: 314 IKTDKTVEADNEIAVLNRRIT 334
I T + + ++A N I+
Sbjct: 114 I-TARNIPRGPQLAAQNLGIS 133
>DQ915447-1|ABI36594.1| 87|Homo sapiens hydroxymethylbilane
synthase protein.
Length = 87
Score = 83.4 bits (197), Expect = 1e-15
Identities = 40/85 (47%), Positives = 56/85 (65%), Gaps = 4/85 (4%)
Query: 207 GALAVECRADNEEVLAMLAPFNHPETYCRVLAERSFLKTLGGGCSAPVGISTKLKQNDNV 266
GAL VE RA ++++L ++ + PET R +AER+FL+ L GGCS PV + T +K
Sbjct: 1 GALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDG--- 57
Query: 267 YKLTLTGAVWSLDGSTKLEETLDQT 291
+L LTG VWSLDGS ++ET+ T
Sbjct: 58 -QLYLTGGVWSLDGSDSIQETMQAT 81
>S60381-1|AAC60602.1| 38|Homo sapiens porphobilinogen deaminase
protein.
Length = 38
Score = 53.2 bits (122), Expect = 2e-06
Identities = 24/38 (63%), Positives = 32/38 (84%), Gaps = 1/38 (2%)
Query: 156 GNLNTRLRKLDDEDGKYSDLILASAGLSRMGWGNRMSK 193
GNLNTRLRKLD++ ++S +ILA+AGL RMGW NR+ +
Sbjct: 2 GNLNTRLRKLDEQQ-EFSAIILATAGLQRMGWHNRVGQ 38
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.315 0.134 0.378
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 54,653,498
Number of Sequences: 224733
Number of extensions: 2280906
Number of successful extensions: 4467
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 4432
Number of HSP's gapped (non-prelim): 18
length of query: 407
length of database: 73,234,838
effective HSP length: 92
effective length of query: 315
effective length of database: 52,559,402
effective search space: 16556211630
effective search space used: 16556211630
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 66 (30.7 bits)
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