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Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA000104-TA|BGIBMGA000104-PA|IPR008968|Mu2 adaptin subunit
(AP50) of AP2, IPR001392|Clathrin adaptor complex, medium chain,
IPR011012|Longin-like
         (571 letters)

Database: human 
           224,733 sequences; 73,234,838 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

X81197-1|CAA57071.1|  511|Homo sapiens archain protein.               530   e-150
BC093638-1|AAH93638.1|  511|Homo sapiens archain protein.             530   e-150
BC093636-1|AAH93636.1|  511|Homo sapiens archain 1 protein.           530   e-150
X81198-1|CAA57072.1|  472|Homo sapiens archain protein.               463   e-130
BC064936-1|AAH64936.1|  189|Homo sapiens ARCN1 protein protein.       252   3e-66
BC040516-1|AAH40516.1|  859|Homo sapiens SGIP1 protein protein.        36   0.51 
BC006337-1|AAH06337.1|  142|Homo sapiens adaptor-related protein...    36   0.51 
AL356913-3|CAI22672.1|  859|Homo sapiens SH3-domain GRB2-like (e...    36   0.51 
AL356913-2|CAI22674.1|  828|Homo sapiens SH3-domain GRB2-like (e...    36   0.51 
AL356913-1|CAI22673.1|  631|Homo sapiens SH3-domain GRB2-like (e...    36   0.51 
AL354978-7|CAH71847.1|  631|Homo sapiens SH3-domain GRB2-like (e...    36   0.51 
AL354978-6|CAH71846.1|  828|Homo sapiens SH3-domain GRB2-like (e...    36   0.51 
AL354978-5|CAH71845.1|  859|Homo sapiens SH3-domain GRB2-like (e...    36   0.51 
AL354978-3|CAH71843.1|  333|Homo sapiens SH3-domain GRB2-like (e...    36   0.51 
AL139147-4|CAI21943.1|  828|Homo sapiens SH3-domain GRB2-like (e...    36   0.51 
AL139147-3|CAI21944.1|  631|Homo sapiens SH3-domain GRB2-like (e...    36   0.51 
AL139147-2|CAI21942.1|  859|Homo sapiens SH3-domain GRB2-like (e...    36   0.51 
AL139147-1|CAI21941.1|  333|Homo sapiens SH3-domain GRB2-like (e...    36   0.51 
AK125044-1|BAC86031.1|  333|Homo sapiens protein ( Homo sapiens ...    36   0.51 
AB210039-1|BAE06121.1|  856|Homo sapiens DKFZp761D221 variant pr...    36   0.51 
X97074-1|CAA65782.1|  142|Homo sapiens clathrin-associated prote...    35   0.89 
AJ010148-1|CAA09018.1|  142|Homo sapiens clathrin-associated pro...    35   0.89 
Y08387-1|CAA69667.1|  453|Homo sapiens mu-adaptin-related protei...    34   1.2  
CR457100-1|CAG33381.1|  144|Homo sapiens AP4S1 protein.                34   1.2  
BC018705-1|AAH18705.1|  453|Homo sapiens AP4M1 protein protein.        34   1.2  
BC009606-1|AAH09606.1|  164|Homo sapiens AP1S3 protein protein.        34   1.2  
AF393369-1|AAL09586.1|  154|Homo sapiens sigma 1C adaptin protein.     34   1.2  
AF155159-1|AAD43329.1|  144|Homo sapiens adaptor-related protein...    34   1.2  
AF155158-1|AAD43328.1|  453|Homo sapiens adaptor-related protein...    34   1.2  
AF020796-1|AAD25869.1|  453|Homo sapiens mu-adaptin-related prot...    34   1.2  
AC093884-1|AAY24166.1|  143|Homo sapiens unknown protein.              34   1.2  
AB030654-1|BAA82970.1|  144|Homo sapiens AP-4 clathrin adaptor-r...    34   1.2  
DQ059565-1|AAY54246.1|  435|Homo sapiens leukemia T cell specifi...    34   1.6  
BC017469-1|AAH17469.1|  423|Homo sapiens adaptor-related protein...    34   1.6  
AF290613-1|AAK28024.1|  423|Homo sapiens clathrin-associated pro...    34   1.6  
AB209808-1|BAD93045.1|  466|Homo sapiens adaptor-related protein...    34   1.6  
BX640759-1|CAE45865.1|  192|Homo sapiens hypothetical protein pr...    33   2.1  
BT006738-1|AAP35384.1|  157|Homo sapiens adaptor-related protein...    32   6.3  
BC071867-1|AAH71867.1|  157|Homo sapiens adaptor-related protein...    32   6.3  
BC001117-1|AAH01117.1|  157|Homo sapiens adaptor-related protein...    32   6.3  
AF251295-1|AAG44595.1|  181|Homo sapiens DC22 protein.                 32   6.3  
AF087876-1|AAP97176.1|  157|Homo sapiens clathrin-associated pro...    32   6.3  
AB015320-1|BAA33392.1|  157|Homo sapiens sigma1B subunit of AP-1...    32   6.3  
BX537780-1|CAD97839.1|  132|Homo sapiens hypothetical protein pr...    31   8.3  

>X81197-1|CAA57071.1|  511|Homo sapiens archain protein.
          Length = 511

 Score =  530 bits (1307), Expect = e-150
 Identities = 264/516 (51%), Positives = 354/516 (68%), Gaps = 14/516 (2%)

Query: 65  LVLIAATVCTKSGKALVSRQFVEMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQP 124
           +VL+AA VCTK+GKA+VSRQFVEMT+ RIEGLLAAFPKLM  G+QHTFVETESVRYVYQP
Sbjct: 1   MVLLAAAVCTKAGKAIVSRQFVEMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQP 60

Query: 125 LDKLYMLLITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALG 184
           ++KLYM+LITTK SNILEDLETLRLFSRV+PEYC  L E E+    F+L+FAFDEIVALG
Sbjct: 61  MEKLYMVLITTKNSNILEDLETLRLFSRVIPEYCRALEENEISEHCFDLIFAFDEIVALG 120

Query: 185 YRESVNLAQVRSFVEMDSHEEKIYQAVRQTQXXXXXXXXXXXXXXLQRERLEAAKRGQPP 244
           YRE+VNLAQ+R+F EMDSHEEK+++AVR+TQ              LQ+ R +A ++G+  
Sbjct: 121 YRENVNLAQIRTFTEMDSHEEKVFRAVRETQEREAKAEMRRKAKELQQARRDAERQGKKA 180

Query: 245 RXXXXXXXXXXXXXXXXXXXXXXIAE----KIPTTPARDTRTVGRSAMKLGSRGTDADSF 300
                                  I E    K+   PAR +      A+KLG++G + D+F
Sbjct: 181 PGFGGFGSSAVSGGSTAAMITETIIETDKPKVAPAPARPSGP--SKALKLGAKGKEVDNF 238

Query: 301 VSRLRSEGD-VTAPVASAAQHDAGK--PVPADHKDVHLRFEERLNLIAGRDGDIQTFELS 357
           V +L+SEG+ + +        +A K    P + + VH++ EE++ L  GRDG +Q  EL 
Sbjct: 239 VDKLKSEGETIMSSSMGKRTSEATKMHAPPINMESVHMKIEEKITLTCGRDGGLQNMELH 298

Query: 358 GLLTLRISNEQFGRIHVHVDNKDSRPLQLQTHPNVDKEAFRSTGVIGLKQAQRPFPMHSD 417
           G++ LRIS++++GRI +HV+N+D + +QLQTHPNVDK+ F +  +IGLK  ++ FP++SD
Sbjct: 299 GMIMLRISDDKYGRIRLHVENEDKKGVQLQTHPNVDKKLFTAESLIGLKNPEKSFPVNSD 358

Query: 418 VGVLKWRLATTNDDKLAPLSVNCWPSEGVNGGCDVNIEYELEQDHLVLTDVNITIPLPSG 477
           VGVLKWRL TT ++   PL++NCWPSE  N GCDVNIEYEL++D+L L DV ITIPLPSG
Sbjct: 359 VGVLKWRLQTT-EESFIPLTINCWPSESGN-GCDVNIEYELQEDNLELNDVVITIPLPSG 416

Query: 478 NTSVVVHQWEGSYTQKGR--NLIWSIPLVSKQQKTGSLEFTVTPSIPNDFFPLSVTWTSE 535
             + V+ + +G Y    R   L W +P++  + K+GSLEF++    PNDFFP+ V++ S+
Sbjct: 417 VGAPVIGEIDGEYRHDSRRNTLEWCLPVIDAKNKSGSLEFSIAGQ-PNDFFPVQVSFVSK 475

Query: 536 TSLALLTAVKVTQAEDGSPVDFSQEISFHADKYEFV 571
            +   +   KVTQ +  SPV FS E +F  DKYE +
Sbjct: 476 KNYCNIQVTKVTQVDGNSPVRFSTETTFLVDKYEIL 511


>BC093638-1|AAH93638.1|  511|Homo sapiens archain protein.
          Length = 511

 Score =  530 bits (1307), Expect = e-150
 Identities = 264/516 (51%), Positives = 354/516 (68%), Gaps = 14/516 (2%)

Query: 65  LVLIAATVCTKSGKALVSRQFVEMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQP 124
           +VL+AA VCTK+GKA+VSRQFVEMT+ RIEGLLAAFPKLM  G+QHTFVETESVRYVYQP
Sbjct: 1   MVLLAAAVCTKAGKAIVSRQFVEMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQP 60

Query: 125 LDKLYMLLITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALG 184
           ++KLYM+LITTK SNILEDLETLRLFSRV+PEYC  L E E+    F+L+FAFDEIVALG
Sbjct: 61  MEKLYMVLITTKNSNILEDLETLRLFSRVIPEYCRALEENEISEHCFDLIFAFDEIVALG 120

Query: 185 YRESVNLAQVRSFVEMDSHEEKIYQAVRQTQXXXXXXXXXXXXXXLQRERLEAAKRGQPP 244
           YRE+VNLAQ+R+F EMDSHEEK+++AVR+TQ              LQ+ R +A ++G+  
Sbjct: 121 YRENVNLAQIRTFTEMDSHEEKVFRAVRETQEREAKAEMRRKAKELQQARRDAERQGKKA 180

Query: 245 RXXXXXXXXXXXXXXXXXXXXXXIAE----KIPTTPARDTRTVGRSAMKLGSRGTDADSF 300
                                  I E    K+   PAR +      A+KLG++G + D+F
Sbjct: 181 PGFGGFGSSAVSGGSTAAMITETIIETDKPKVAPAPARPSGP--SKALKLGAKGKEVDNF 238

Query: 301 VSRLRSEGD-VTAPVASAAQHDAGK--PVPADHKDVHLRFEERLNLIAGRDGDIQTFELS 357
           V +L+SEG+ + +        +A K    P + + VH++ EE++ L  GRDG +Q  EL 
Sbjct: 239 VDKLKSEGETIMSSSMGKRTSEATKMHAPPINMESVHMKIEEKITLTCGRDGGLQNMELH 298

Query: 358 GLLTLRISNEQFGRIHVHVDNKDSRPLQLQTHPNVDKEAFRSTGVIGLKQAQRPFPMHSD 417
           G++ LRIS++++GRI +HV+N+D + +QLQTHPNVDK+ F +  +IGLK  ++ FP++SD
Sbjct: 299 GMIMLRISDDKYGRIRLHVENEDKKGVQLQTHPNVDKKLFTAESLIGLKNPEKSFPVNSD 358

Query: 418 VGVLKWRLATTNDDKLAPLSVNCWPSEGVNGGCDVNIEYELEQDHLVLTDVNITIPLPSG 477
           VGVLKWRL TT ++   PL++NCWPSE  N GCDVNIEYEL++D+L L DV ITIPLPSG
Sbjct: 359 VGVLKWRLQTT-EESFIPLTINCWPSESGN-GCDVNIEYELQEDNLELNDVVITIPLPSG 416

Query: 478 NTSVVVHQWEGSYTQKGR--NLIWSIPLVSKQQKTGSLEFTVTPSIPNDFFPLSVTWTSE 535
             + V+ + +G Y    R   L W +P++  + K+GSLEF++    PNDFFP+ V++ S+
Sbjct: 417 VGAPVIGEIDGEYRHDSRRNTLEWCLPVIDAKNKSGSLEFSIAGQ-PNDFFPVQVSFVSK 475

Query: 536 TSLALLTAVKVTQAEDGSPVDFSQEISFHADKYEFV 571
            +   +   KVTQ +  SPV FS E +F  DKYE +
Sbjct: 476 KNYCNIQVTKVTQVDGNSPVRFSTETTFLVDKYEIL 511


>BC093636-1|AAH93636.1|  511|Homo sapiens archain 1 protein.
          Length = 511

 Score =  530 bits (1307), Expect = e-150
 Identities = 264/516 (51%), Positives = 354/516 (68%), Gaps = 14/516 (2%)

Query: 65  LVLIAATVCTKSGKALVSRQFVEMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQP 124
           +VL+AA VCTK+GKA+VSRQFVEMT+ RIEGLLAAFPKLM  G+QHTFVETESVRYVYQP
Sbjct: 1   MVLLAAAVCTKAGKAIVSRQFVEMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQP 60

Query: 125 LDKLYMLLITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALG 184
           ++KLYM+LITTK SNILEDLETLRLFSRV+PEYC  L E E+    F+L+FAFDEIVALG
Sbjct: 61  MEKLYMVLITTKNSNILEDLETLRLFSRVIPEYCRALEENEISEHCFDLIFAFDEIVALG 120

Query: 185 YRESVNLAQVRSFVEMDSHEEKIYQAVRQTQXXXXXXXXXXXXXXLQRERLEAAKRGQPP 244
           YRE+VNLAQ+R+F EMDSHEEK+++AVR+TQ              LQ+ R +A ++G+  
Sbjct: 121 YRENVNLAQIRTFTEMDSHEEKVFRAVRETQEREAKAEMRRKAKELQQARRDAERQGKKA 180

Query: 245 RXXXXXXXXXXXXXXXXXXXXXXIAE----KIPTTPARDTRTVGRSAMKLGSRGTDADSF 300
                                  I E    K+   PAR +      A+KLG++G + D+F
Sbjct: 181 PGFGGFGSSAVSGGSTAAMITETIIETDKPKVAPAPARPSGP--SKALKLGAKGKEVDNF 238

Query: 301 VSRLRSEGD-VTAPVASAAQHDAGK--PVPADHKDVHLRFEERLNLIAGRDGDIQTFELS 357
           V +L+SEG+ + +        +A K    P + + VH++ EE++ L  GRDG +Q  EL 
Sbjct: 239 VDKLKSEGETIMSSSMGKRTSEATKMHAPPINMESVHMKIEEKITLTCGRDGGLQNMELH 298

Query: 358 GLLTLRISNEQFGRIHVHVDNKDSRPLQLQTHPNVDKEAFRSTGVIGLKQAQRPFPMHSD 417
           G++ LRIS++++GRI +HV+N+D + +QLQTHPNVDK+ F +  +IGLK  ++ FP++SD
Sbjct: 299 GMIMLRISDDKYGRIRLHVENEDKKGVQLQTHPNVDKKLFTAESLIGLKNPEKSFPVNSD 358

Query: 418 VGVLKWRLATTNDDKLAPLSVNCWPSEGVNGGCDVNIEYELEQDHLVLTDVNITIPLPSG 477
           VGVLKWRL TT ++   PL++NCWPSE  N GCDVNIEYEL++D+L L DV ITIPLPSG
Sbjct: 359 VGVLKWRLQTT-EESFIPLTINCWPSESGN-GCDVNIEYELQEDNLELNDVVITIPLPSG 416

Query: 478 NTSVVVHQWEGSYTQKGR--NLIWSIPLVSKQQKTGSLEFTVTPSIPNDFFPLSVTWTSE 535
             + V+ + +G Y    R   L W +P++  + K+GSLEF++    PNDFFP+ V++ S+
Sbjct: 417 VGAPVIGEIDGEYRHDSRRNTLEWCLPVIDAKNKSGSLEFSIAGQ-PNDFFPVQVSFVSK 475

Query: 536 TSLALLTAVKVTQAEDGSPVDFSQEISFHADKYEFV 571
            +   +   KVTQ +  SPV FS E +F  DKYE +
Sbjct: 476 KNYCNIQVTKVTQVDGNSPVRFSTETTFLVDKYEIL 511


>X81198-1|CAA57072.1|  472|Homo sapiens archain protein.
          Length = 472

 Score =  463 bits (1142), Expect = e-130
 Identities = 232/477 (48%), Positives = 316/477 (66%), Gaps = 14/477 (2%)

Query: 104 MTGGRQHTFVETESVRYVYQPLDKLYMLLITTKASNILEDLETLRLFSRVVPEYCVQLTE 163
           M  G+QHTFVETESVRYVYQP++KLYM+LITTK SNILEDLETLRLFSRV+PEYC  L E
Sbjct: 1   MNTGKQHTFVETESVRYVYQPMEKLYMVLITTKNSNILEDLETLRLFSRVIPEYCRALEE 60

Query: 164 TEVLNQAFNLLFAFDEIVALGYRESVNLAQVRSFVEMDSHEEKIYQAVRQTQXXXXXXXX 223
            E+    F+L+FAFDEIVALGYRE+VNLAQ+R+F EMDSHEEK+++AVR+TQ        
Sbjct: 61  NEISEHCFDLIFAFDEIVALGYRENVNLAQIRTFTEMDSHEEKVFRAVRETQEREAKAEM 120

Query: 224 XXXXXXLQRERLEAAKRGQPPRXXXXXXXXXXXXXXXXXXXXXXIAE----KIPTTPARD 279
                 LQ+ R +A ++G+                         I E    K+   PAR 
Sbjct: 121 RRKAKELQQARRDAERQGKKAPGFGGFGSSAVSGGSTAAMITETIIETDKPKVAPAPARP 180

Query: 280 TRTVGRSAMKLGSRGTDADSFVSRLRSEGD-VTAPVASAAQHDAGK--PVPADHKDVHLR 336
           +      A+KLG++G + D+FV +L+SEG+ + +        +A K    P + + VH++
Sbjct: 181 SGP--SKALKLGAKGKEVDNFVDKLKSEGETIMSSSMGKRTSEATKMHAPPINMESVHMK 238

Query: 337 FEERLNLIAGRDGDIQTFELSGLLTLRISNEQFGRIHVHVDNKDSRPLQLQTHPNVDKEA 396
            EE++ L  GRDG +Q  EL G++ LRIS++ +GRI +HV+N+D + +QLQTHPNVDK+ 
Sbjct: 239 IEEKITLTCGRDGGLQNMELHGMIMLRISDDNYGRIRLHVENEDKKGVQLQTHPNVDKKL 298

Query: 397 FRSTGVIGLKQAQRPFPMHSDVGVLKWRLATTNDDKLAPLSVNCWPSEGVNGGCDVNIEY 456
           F +  +IGLK  ++ FP++SDVGVLKWRL TT ++   PL++NCWPSE  N GCDVNIEY
Sbjct: 299 FTAESLIGLKNPEKSFPVNSDVGVLKWRLQTT-EESFIPLTINCWPSESGN-GCDVNIEY 356

Query: 457 ELEQDHLVLTDVNITIPLPSGNTSVVVHQWEGSYTQKGR--NLIWSIPLVSKQQKTGSLE 514
           EL++D+L L DV ITIPLPSG  + V+ + +G Y    R   L W +P++  + K+GSLE
Sbjct: 357 ELQEDNLELNDVVITIPLPSGVGAPVIGEIDGEYRHDSRRNTLEWCLPVIDAKNKSGSLE 416

Query: 515 FTVTPSIPNDFFPLSVTWTSETSLALLTAVKVTQAEDGSPVDFSQEISFHADKYEFV 571
           F++    PNDFFP+ V++ S+ +   +   KVTQ +  SPV FS E +F  DKYE +
Sbjct: 417 FSIAGQ-PNDFFPVQVSFVSKKNYCNIQVTKVTQVDGNSPVRFSTETTFLVDKYEIL 472


>BC064936-1|AAH64936.1|  189|Homo sapiens ARCN1 protein protein.
          Length = 189

 Score =  252 bits (617), Expect = 3e-66
 Identities = 117/151 (77%), Positives = 137/151 (90%)

Query: 65  LVLIAATVCTKSGKALVSRQFVEMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQP 124
           +VL+AA VCTK+GKA+VSRQFVEMT+ RIEGLLAAFPKLM  G+QHTFVETESVRYVYQP
Sbjct: 1   MVLLAAAVCTKAGKAIVSRQFVEMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQP 60

Query: 125 LDKLYMLLITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALG 184
           ++KLYM+LITTK SNILEDLETLRLFSRV+PEYC  L E E+    F+L+FAFDEIVALG
Sbjct: 61  MEKLYMVLITTKNSNILEDLETLRLFSRVIPEYCRALEENEISEHCFDLIFAFDEIVALG 120

Query: 185 YRESVNLAQVRSFVEMDSHEEKIYQAVRQTQ 215
           YRE+VNLAQ+R+F EMDSHEEK+++AVR+TQ
Sbjct: 121 YRENVNLAQIRTFTEMDSHEEKVFRAVRETQ 151


>BC040516-1|AAH40516.1|  859|Homo sapiens SGIP1 protein protein.
          Length = 859

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 14/139 (10%)

Query: 409 QRPFPMHSDVGVLKWRLATTNDDKLA-PLSVNCWPSEGVNGGCDVNIEYELEQDHLV--- 464
           Q+P   + +V +LK++++          L+VN W  E      D+ I+Y+   D +    
Sbjct: 693 QKPQATYYNVDMLKYQVSAQGIQSTPLNLAVN-WRCEP--SSTDLRIDYKYNTDAMTTAV 749

Query: 465 -LTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSL-----EFTVT 518
            L +V   +P+  G T +        +  + + ++W IP +S++ + G +      F ++
Sbjct: 750 ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLS 809

Query: 519 PSIPNDFFPLSVTWTSETS 537
              P+   PL V +TSE S
Sbjct: 810 EG-PSKPSPLVVQFTSEGS 827


>BC006337-1|AAH06337.1|  142|Homo sapiens adaptor-related protein
           complex 2, sigma 1 subunit protein.
          Length = 142

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 28/133 (21%), Positives = 60/133 (45%), Gaps = 3/133 (2%)

Query: 75  KSGKALVSRQFVEMTKARIEGLLAAFPKLMT-GGRQHT-FVETESVRYVYQPLDKLYMLL 132
           ++GK  +++ +++      + L+     ++T    +HT FVE  + + +Y+    LY  +
Sbjct: 10  RAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCI 69

Query: 133 ITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALG-YRESVNL 191
                 N L  LE +  F  V+ EY   + E +++   + +    DE+   G  RE+   
Sbjct: 70  CVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQT 129

Query: 192 AQVRSFVEMDSHE 204
             ++  + + S E
Sbjct: 130 KVLKQLLMLQSLE 142


>AL356913-3|CAI22672.1|  859|Homo sapiens SH3-domain GRB2-like
           (endophilin) interacting protein 1 protein.
          Length = 859

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 14/139 (10%)

Query: 409 QRPFPMHSDVGVLKWRLATTNDDKLA-PLSVNCWPSEGVNGGCDVNIEYELEQDHLV--- 464
           Q+P   + +V +LK++++          L+VN W  E      D+ I+Y+   D +    
Sbjct: 693 QKPQATYYNVDMLKYQVSAQGIQSTPLNLAVN-WRCEP--SSTDLRIDYKYNTDAMTTAV 749

Query: 465 -LTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSL-----EFTVT 518
            L +V   +P+  G T +        +  + + ++W IP +S++ + G +      F ++
Sbjct: 750 ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLS 809

Query: 519 PSIPNDFFPLSVTWTSETS 537
              P+   PL V +TSE S
Sbjct: 810 EG-PSKPSPLVVQFTSEGS 827


>AL356913-2|CAI22674.1|  828|Homo sapiens SH3-domain GRB2-like
           (endophilin) interacting protein 1 protein.
          Length = 828

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 14/139 (10%)

Query: 409 QRPFPMHSDVGVLKWRLATTNDDKLA-PLSVNCWPSEGVNGGCDVNIEYELEQDHLV--- 464
           Q+P   + +V +LK++++          L+VN W  E      D+ I+Y+   D +    
Sbjct: 662 QKPQATYYNVDMLKYQVSAQGIQSTPLNLAVN-WRCEP--SSTDLRIDYKYNTDAMTTAV 718

Query: 465 -LTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSL-----EFTVT 518
            L +V   +P+  G T +        +  + + ++W IP +S++ + G +      F ++
Sbjct: 719 ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLS 778

Query: 519 PSIPNDFFPLSVTWTSETS 537
              P+   PL V +TSE S
Sbjct: 779 EG-PSKPSPLVVQFTSEGS 796


>AL356913-1|CAI22673.1|  631|Homo sapiens SH3-domain GRB2-like
           (endophilin) interacting protein 1 protein.
          Length = 631

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 14/139 (10%)

Query: 409 QRPFPMHSDVGVLKWRLATTNDDKLA-PLSVNCWPSEGVNGGCDVNIEYELEQDHLV--- 464
           Q+P   + +V +LK++++          L+VN W  E      D+ I+Y+   D +    
Sbjct: 465 QKPQATYYNVDMLKYQVSAQGIQSTPLNLAVN-WRCEP--SSTDLRIDYKYNTDAMTTAV 521

Query: 465 -LTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSL-----EFTVT 518
            L +V   +P+  G T +        +  + + ++W IP +S++ + G +      F ++
Sbjct: 522 ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLS 581

Query: 519 PSIPNDFFPLSVTWTSETS 537
              P+   PL V +TSE S
Sbjct: 582 EG-PSKPSPLVVQFTSEGS 599


>AL354978-7|CAH71847.1|  631|Homo sapiens SH3-domain GRB2-like
           (endophilin) interacting protein 1 protein.
          Length = 631

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 14/139 (10%)

Query: 409 QRPFPMHSDVGVLKWRLATTNDDKLA-PLSVNCWPSEGVNGGCDVNIEYELEQDHLV--- 464
           Q+P   + +V +LK++++          L+VN W  E      D+ I+Y+   D +    
Sbjct: 465 QKPQATYYNVDMLKYQVSAQGIQSTPLNLAVN-WRCEP--SSTDLRIDYKYNTDAMTTAV 521

Query: 465 -LTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSL-----EFTVT 518
            L +V   +P+  G T +        +  + + ++W IP +S++ + G +      F ++
Sbjct: 522 ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLS 581

Query: 519 PSIPNDFFPLSVTWTSETS 537
              P+   PL V +TSE S
Sbjct: 582 EG-PSKPSPLVVQFTSEGS 599


>AL354978-6|CAH71846.1|  828|Homo sapiens SH3-domain GRB2-like
           (endophilin) interacting protein 1 protein.
          Length = 828

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 14/139 (10%)

Query: 409 QRPFPMHSDVGVLKWRLATTNDDKLA-PLSVNCWPSEGVNGGCDVNIEYELEQDHLV--- 464
           Q+P   + +V +LK++++          L+VN W  E      D+ I+Y+   D +    
Sbjct: 662 QKPQATYYNVDMLKYQVSAQGIQSTPLNLAVN-WRCEP--SSTDLRIDYKYNTDAMTTAV 718

Query: 465 -LTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSL-----EFTVT 518
            L +V   +P+  G T +        +  + + ++W IP +S++ + G +      F ++
Sbjct: 719 ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLS 778

Query: 519 PSIPNDFFPLSVTWTSETS 537
              P+   PL V +TSE S
Sbjct: 779 EG-PSKPSPLVVQFTSEGS 796


>AL354978-5|CAH71845.1|  859|Homo sapiens SH3-domain GRB2-like
           (endophilin) interacting protein 1 protein.
          Length = 859

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 14/139 (10%)

Query: 409 QRPFPMHSDVGVLKWRLATTNDDKLA-PLSVNCWPSEGVNGGCDVNIEYELEQDHLV--- 464
           Q+P   + +V +LK++++          L+VN W  E      D+ I+Y+   D +    
Sbjct: 693 QKPQATYYNVDMLKYQVSAQGIQSTPLNLAVN-WRCEP--SSTDLRIDYKYNTDAMTTAV 749

Query: 465 -LTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSL-----EFTVT 518
            L +V   +P+  G T +        +  + + ++W IP +S++ + G +      F ++
Sbjct: 750 ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLS 809

Query: 519 PSIPNDFFPLSVTWTSETS 537
              P+   PL V +TSE S
Sbjct: 810 EG-PSKPSPLVVQFTSEGS 827


>AL354978-3|CAH71843.1|  333|Homo sapiens SH3-domain GRB2-like
           (endophilin) interacting protein 1 protein.
          Length = 333

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 14/139 (10%)

Query: 409 QRPFPMHSDVGVLKWRLATTNDDKLA-PLSVNCWPSEGVNGGCDVNIEYELEQDHLV--- 464
           Q+P   + +V +LK++++          L+VN W  E      D+ I+Y+   D +    
Sbjct: 167 QKPQATYYNVDMLKYQVSAQGIQSTPLNLAVN-WRCEP--SSTDLRIDYKYNTDAMTTAV 223

Query: 465 -LTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSL-----EFTVT 518
            L +V   +P+  G T +        +  + + ++W IP +S++ + G +      F ++
Sbjct: 224 ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLS 283

Query: 519 PSIPNDFFPLSVTWTSETS 537
              P+   PL V +TSE S
Sbjct: 284 EG-PSKPSPLVVQFTSEGS 301


>AL139147-4|CAI21943.1|  828|Homo sapiens SH3-domain GRB2-like
           (endophilin) interacting protein 1 protein.
          Length = 828

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 14/139 (10%)

Query: 409 QRPFPMHSDVGVLKWRLATTNDDKLA-PLSVNCWPSEGVNGGCDVNIEYELEQDHLV--- 464
           Q+P   + +V +LK++++          L+VN W  E      D+ I+Y+   D +    
Sbjct: 662 QKPQATYYNVDMLKYQVSAQGIQSTPLNLAVN-WRCEP--SSTDLRIDYKYNTDAMTTAV 718

Query: 465 -LTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSL-----EFTVT 518
            L +V   +P+  G T +        +  + + ++W IP +S++ + G +      F ++
Sbjct: 719 ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLS 778

Query: 519 PSIPNDFFPLSVTWTSETS 537
              P+   PL V +TSE S
Sbjct: 779 EG-PSKPSPLVVQFTSEGS 796


>AL139147-3|CAI21944.1|  631|Homo sapiens SH3-domain GRB2-like
           (endophilin) interacting protein 1 protein.
          Length = 631

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 14/139 (10%)

Query: 409 QRPFPMHSDVGVLKWRLATTNDDKLA-PLSVNCWPSEGVNGGCDVNIEYELEQDHLV--- 464
           Q+P   + +V +LK++++          L+VN W  E      D+ I+Y+   D +    
Sbjct: 465 QKPQATYYNVDMLKYQVSAQGIQSTPLNLAVN-WRCEP--SSTDLRIDYKYNTDAMTTAV 521

Query: 465 -LTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSL-----EFTVT 518
            L +V   +P+  G T +        +  + + ++W IP +S++ + G +      F ++
Sbjct: 522 ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLS 581

Query: 519 PSIPNDFFPLSVTWTSETS 537
              P+   PL V +TSE S
Sbjct: 582 EG-PSKPSPLVVQFTSEGS 599


>AL139147-2|CAI21942.1|  859|Homo sapiens SH3-domain GRB2-like
           (endophilin) interacting protein 1 protein.
          Length = 859

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 14/139 (10%)

Query: 409 QRPFPMHSDVGVLKWRLATTNDDKLA-PLSVNCWPSEGVNGGCDVNIEYELEQDHLV--- 464
           Q+P   + +V +LK++++          L+VN W  E      D+ I+Y+   D +    
Sbjct: 693 QKPQATYYNVDMLKYQVSAQGIQSTPLNLAVN-WRCEP--SSTDLRIDYKYNTDAMTTAV 749

Query: 465 -LTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSL-----EFTVT 518
            L +V   +P+  G T +        +  + + ++W IP +S++ + G +      F ++
Sbjct: 750 ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLS 809

Query: 519 PSIPNDFFPLSVTWTSETS 537
              P+   PL V +TSE S
Sbjct: 810 EG-PSKPSPLVVQFTSEGS 827


>AL139147-1|CAI21941.1|  333|Homo sapiens SH3-domain GRB2-like
           (endophilin) interacting protein 1 protein.
          Length = 333

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 14/139 (10%)

Query: 409 QRPFPMHSDVGVLKWRLATTNDDKLA-PLSVNCWPSEGVNGGCDVNIEYELEQDHLV--- 464
           Q+P   + +V +LK++++          L+VN W  E      D+ I+Y+   D +    
Sbjct: 167 QKPQATYYNVDMLKYQVSAQGIQSTPLNLAVN-WRCEP--SSTDLRIDYKYNTDAMTTAV 223

Query: 465 -LTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSL-----EFTVT 518
            L +V   +P+  G T +        +  + + ++W IP +S++ + G +      F ++
Sbjct: 224 ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLS 283

Query: 519 PSIPNDFFPLSVTWTSETS 537
              P+   PL V +TSE S
Sbjct: 284 EG-PSKPSPLVVQFTSEGS 301


>AK125044-1|BAC86031.1|  333|Homo sapiens protein ( Homo sapiens
           cDNA FLJ43054 fis, clone BRTHA3007113. ).
          Length = 333

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 14/139 (10%)

Query: 409 QRPFPMHSDVGVLKWRLATTNDDKLA-PLSVNCWPSEGVNGGCDVNIEYELEQDHLV--- 464
           Q+P   + +V +LK++++          L+VN W  E      D+ I+Y+   D +    
Sbjct: 167 QKPQATYYNVDMLKYQVSAQGIQSTPLNLAVN-WRCEP--SSTDLRIDYKYNTDAMTTAV 223

Query: 465 -LTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSL-----EFTVT 518
            L +V   +P+  G T +        +  + + ++W IP +S++ + G +      F ++
Sbjct: 224 ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLS 283

Query: 519 PSIPNDFFPLSVTWTSETS 537
              P+   PL V +TSE S
Sbjct: 284 EG-PSKPSPLVVQFTSEGS 301


>AB210039-1|BAE06121.1|  856|Homo sapiens DKFZp761D221 variant
           protein protein.
          Length = 856

 Score = 35.5 bits (78), Expect = 0.51
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 14/139 (10%)

Query: 409 QRPFPMHSDVGVLKWRLATTNDDKLA-PLSVNCWPSEGVNGGCDVNIEYELEQDHLV--- 464
           Q+P   + +V +LK++++          L+VN W  E      D+ I+Y+   D +    
Sbjct: 690 QKPQATYYNVDMLKYQVSAQGIQSTPLNLAVN-WRCEP--SSTDLRIDYKYNTDAMTTAV 746

Query: 465 -LTDVNITIPLPSGNTSVVVHQWEGSYTQKGRNLIWSIPLVSKQQKTGSL-----EFTVT 518
            L +V   +P+  G T +        +  + + ++W IP +S++ + G +      F ++
Sbjct: 747 ALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLS 806

Query: 519 PSIPNDFFPLSVTWTSETS 537
              P+   PL V +TSE S
Sbjct: 807 EG-PSKPSPLVVQFTSEGS 824


>X97074-1|CAA65782.1|  142|Homo sapiens clathrin-associated protein
           protein.
          Length = 142

 Score = 34.7 bits (76), Expect = 0.89
 Identities = 28/133 (21%), Positives = 60/133 (45%), Gaps = 3/133 (2%)

Query: 75  KSGKALVSRQFVEMTKARIEGLLAAFPKLMT-GGRQHT-FVETESVRYVYQPLDKLYMLL 132
           ++GK  +++ +++      + L+     ++T    +HT FVE  + + +Y+    LY  +
Sbjct: 10  RAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCI 69

Query: 133 ITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALG-YRESVNL 191
                 N L  LE +  F  V+ EY   + E +++   + +    DE+   G  RE+   
Sbjct: 70  CVDVNDNKLAYLEGIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQT 129

Query: 192 AQVRSFVEMDSHE 204
             ++  + + S E
Sbjct: 130 KVLKQLLMLQSLE 142


>AJ010148-1|CAA09018.1|  142|Homo sapiens clathrin-associated
           protein AP17 protein.
          Length = 142

 Score = 34.7 bits (76), Expect = 0.89
 Identities = 28/133 (21%), Positives = 60/133 (45%), Gaps = 3/133 (2%)

Query: 75  KSGKALVSRQFVEMTKARIEGLLAAFPKLMT-GGRQHT-FVETESVRYVYQPLDKLYMLL 132
           ++GK  +++ +++      + L+     ++T    +HT FVE  + + +Y+    LY  +
Sbjct: 10  RAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCI 69

Query: 133 ITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALG-YRESVNL 191
                 N L  LE +  F  V+ EY   + E +++   + +    DE+   G  RE+   
Sbjct: 70  CVDVNDNKLAYLEGIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQT 129

Query: 192 AQVRSFVEMDSHE 204
             ++  + + S E
Sbjct: 130 KVLKQLLMLQSLE 142


>Y08387-1|CAA69667.1|  453|Homo sapiens mu-adaptin-related protein 2
           protein.
          Length = 453

 Score = 34.3 bits (75), Expect = 1.2
 Identities = 16/75 (21%), Positives = 39/75 (52%)

Query: 128 LYMLLITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRE 187
           LY+++ T++  +    LE L   + ++ +YC  L E  +      +    DE++  GY +
Sbjct: 64  LYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQ 123

Query: 188 SVNLAQVRSFVEMDS 202
           + +   +R+F++ ++
Sbjct: 124 TTSTEMLRNFIQTEA 138


>CR457100-1|CAG33381.1|  144|Homo sapiens AP4S1 protein.
          Length = 144

 Score = 34.3 bits (75), Expect = 1.2
 Identities = 24/122 (19%), Positives = 54/122 (44%), Gaps = 2/122 (1%)

Query: 75  KSGKALVSRQF--VEMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDKLYMLL 132
           K G+  +S+ +  V++ K  +         L     Q +F+E +  + +Y+    L++++
Sbjct: 10  KQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVV 69

Query: 133 ITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRESVNLA 192
                 N +   E +  F  V+ EY  +++E +++     +    DE+V  G     N A
Sbjct: 70  GVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRA 129

Query: 193 QV 194
           ++
Sbjct: 130 RI 131


>BC018705-1|AAH18705.1|  453|Homo sapiens AP4M1 protein protein.
          Length = 453

 Score = 34.3 bits (75), Expect = 1.2
 Identities = 16/75 (21%), Positives = 39/75 (52%)

Query: 128 LYMLLITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRE 187
           LY+++ T++  +    LE L   + ++ +YC  L E  +      +    DE++  GY +
Sbjct: 64  LYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQ 123

Query: 188 SVNLAQVRSFVEMDS 202
           + +   +R+F++ ++
Sbjct: 124 TTSTEMLRNFIQTEA 138


>BC009606-1|AAH09606.1|  164|Homo sapiens AP1S3 protein protein.
          Length = 164

 Score = 34.3 bits (75), Expect = 1.2
 Identities = 23/104 (22%), Positives = 45/104 (43%), Gaps = 1/104 (0%)

Query: 103 LMTGGRQHTFVETESVRYVYQPLDKLYMLLITTKASNILEDLETLRLFSRVVPEYCVQLT 162
           L  G R  +FV+ + ++ VY+    LY         N L  LE +  +  ++ +Y   + 
Sbjct: 40  LSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVC 99

Query: 163 ETEVLNQAFNLLFAFDEIVALG-YRESVNLAQVRSFVEMDSHEE 205
           E +++       F  DE +  G  +E+     V++  + D  +E
Sbjct: 100 ELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQE 143


>AF393369-1|AAL09586.1|  154|Homo sapiens sigma 1C adaptin protein.
          Length = 154

 Score = 34.3 bits (75), Expect = 1.2
 Identities = 23/104 (22%), Positives = 45/104 (43%), Gaps = 1/104 (0%)

Query: 103 LMTGGRQHTFVETESVRYVYQPLDKLYMLLITTKASNILEDLETLRLFSRVVPEYCVQLT 162
           L  G R  +FV+ + ++ VY+    LY         N L  LE +  +  ++ +Y   + 
Sbjct: 40  LSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVC 99

Query: 163 ETEVLNQAFNLLFAFDEIVALG-YRESVNLAQVRSFVEMDSHEE 205
           E +++       F  DE +  G  +E+     V++  + D  +E
Sbjct: 100 ELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQE 143


>AF155159-1|AAD43329.1|  144|Homo sapiens adaptor-related protein
           complex AP-4 sigma4 subunit protein.
          Length = 144

 Score = 34.3 bits (75), Expect = 1.2
 Identities = 24/122 (19%), Positives = 54/122 (44%), Gaps = 2/122 (1%)

Query: 75  KSGKALVSRQF--VEMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDKLYMLL 132
           K G+  +S+ +  V++ K  +         L     Q +F+E +  + +Y+    L++++
Sbjct: 10  KQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVV 69

Query: 133 ITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRESVNLA 192
                 N +   E +  F  V+ EY  +++E +++     +    DE+V  G     N A
Sbjct: 70  GVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRA 129

Query: 193 QV 194
           ++
Sbjct: 130 RI 131


>AF155158-1|AAD43328.1|  453|Homo sapiens adaptor-related protein
           complex AP-4 mu4 subunit protein.
          Length = 453

 Score = 34.3 bits (75), Expect = 1.2
 Identities = 16/75 (21%), Positives = 39/75 (52%)

Query: 128 LYMLLITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRE 187
           LY+++ T++  +    LE L   + ++ +YC  L E  +      +    DE++  GY +
Sbjct: 64  LYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQ 123

Query: 188 SVNLAQVRSFVEMDS 202
           + +   +R+F++ ++
Sbjct: 124 TTSTEMLRNFIQTEA 138


>AF020796-1|AAD25869.1|  453|Homo sapiens mu-adaptin-related protein
           2 protein.
          Length = 453

 Score = 34.3 bits (75), Expect = 1.2
 Identities = 16/75 (21%), Positives = 39/75 (52%)

Query: 128 LYMLLITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRE 187
           LY+++ T++  +    LE L   + ++ +YC  L E  +      +    DE++  GY +
Sbjct: 64  LYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQ 123

Query: 188 SVNLAQVRSFVEMDS 202
           + +   +R+F++ ++
Sbjct: 124 TTSTEMLRNFIQTEA 138


>AC093884-1|AAY24166.1|  143|Homo sapiens unknown protein.
          Length = 143

 Score = 34.3 bits (75), Expect = 1.2
 Identities = 23/104 (22%), Positives = 45/104 (43%), Gaps = 1/104 (0%)

Query: 103 LMTGGRQHTFVETESVRYVYQPLDKLYMLLITTKASNILEDLETLRLFSRVVPEYCVQLT 162
           L  G R  +FV+ + ++ VY+    LY         N L  LE +  +  ++ +Y   + 
Sbjct: 40  LSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVC 99

Query: 163 ETEVLNQAFNLLFAFDEIVALG-YRESVNLAQVRSFVEMDSHEE 205
           E +++       F  DE +  G  +E+     V++  + D  +E
Sbjct: 100 ELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQE 143


>AB030654-1|BAA82970.1|  144|Homo sapiens AP-4 clathrin
           adaptor-related complex sigma4 subunit protein.
          Length = 144

 Score = 34.3 bits (75), Expect = 1.2
 Identities = 24/122 (19%), Positives = 54/122 (44%), Gaps = 2/122 (1%)

Query: 75  KSGKALVSRQF--VEMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDKLYMLL 132
           K G+  +S+ +  V++ K  +         L     Q +F+E +  + +Y+    L++++
Sbjct: 10  KQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVV 69

Query: 133 ITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRESVNLA 192
                 N +   E +  F  V+ EY  +++E +++     +    DE+V  G     N A
Sbjct: 70  GVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRA 129

Query: 193 QV 194
           ++
Sbjct: 130 RI 131


>DQ059565-1|AAY54246.1|  435|Homo sapiens leukemia T cell specific
           adaptor-related protein 1 mu1 subunit protein.
          Length = 435

 Score = 33.9 bits (74), Expect = 1.6
 Identities = 24/137 (17%), Positives = 58/137 (42%), Gaps = 1/137 (0%)

Query: 69  AATVCTKSGKALVSRQFV-EMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDK 127
           A  V    GK L+ R +  ++  + +E  +    +    G     +    VR+++   + 
Sbjct: 5   AVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNN 64

Query: 128 LYMLLITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRE 187
           LY++  + K + +      L    +V  EY  +L E  + +    +    DE++  GY +
Sbjct: 65  LYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQ 124

Query: 188 SVNLAQVRSFVEMDSHE 204
           + +   ++ ++  + H+
Sbjct: 125 TTDSKILQEYITQEGHK 141


>BC017469-1|AAH17469.1|  423|Homo sapiens adaptor-related protein
           complex 1, mu 1 subunit protein.
          Length = 423

 Score = 33.9 bits (74), Expect = 1.6
 Identities = 24/137 (17%), Positives = 58/137 (42%), Gaps = 1/137 (0%)

Query: 69  AATVCTKSGKALVSRQFV-EMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDK 127
           A  V    GK L+ R +  ++  + +E  +    +    G     +    VR+++   + 
Sbjct: 5   AVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNN 64

Query: 128 LYMLLITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRE 187
           LY++  + K + +      L    +V  EY  +L E  + +    +    DE++  GY +
Sbjct: 65  LYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQ 124

Query: 188 SVNLAQVRSFVEMDSHE 204
           + +   ++ ++  + H+
Sbjct: 125 TTDSKILQEYITQEGHK 141


>AF290613-1|AAK28024.1|  423|Homo sapiens clathrin-associated
           protein AP47 protein.
          Length = 423

 Score = 33.9 bits (74), Expect = 1.6
 Identities = 24/137 (17%), Positives = 58/137 (42%), Gaps = 1/137 (0%)

Query: 69  AATVCTKSGKALVSRQFV-EMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDK 127
           A  V    GK L+ R +  ++  + +E  +    +    G     +    VR+++   + 
Sbjct: 5   AVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNN 64

Query: 128 LYMLLITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRE 187
           LY++  + K + +      L    +V  EY  +L E  + +    +    DE++  GY +
Sbjct: 65  LYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQ 124

Query: 188 SVNLAQVRSFVEMDSHE 204
           + +   ++ ++  + H+
Sbjct: 125 TTDSKILQEYITQEGHK 141


>AB209808-1|BAD93045.1|  466|Homo sapiens adaptor-related protein
           complex 1, mu 1 subunit variant protein.
          Length = 466

 Score = 33.9 bits (74), Expect = 1.6
 Identities = 24/137 (17%), Positives = 58/137 (42%), Gaps = 1/137 (0%)

Query: 69  AATVCTKSGKALVSRQFV-EMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDK 127
           A  V    GK L+ R +  ++  + +E  +    +    G     +    VR+++   + 
Sbjct: 36  AVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNN 95

Query: 128 LYMLLITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRE 187
           LY++  + K + +      L    +V  EY  +L E  + +    +    DE++  GY +
Sbjct: 96  LYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQ 155

Query: 188 SVNLAQVRSFVEMDSHE 204
           + +   ++ ++  + H+
Sbjct: 156 TTDSKILQEYITQEGHK 172


>BX640759-1|CAE45865.1|  192|Homo sapiens hypothetical protein
           protein.
          Length = 192

 Score = 33.5 bits (73), Expect = 2.1
 Identities = 16/75 (21%), Positives = 39/75 (52%)

Query: 128 LYMLLITTKASNILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRE 187
           LY+++ T++  +    LE L   + ++ +YC  L E  +      +    DE++  GY +
Sbjct: 49  LYLVVTTSENVSPFSLLELLSGLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQ 108

Query: 188 SVNLAQVRSFVEMDS 202
           + +   +R+F++ ++
Sbjct: 109 TTSTEMLRNFIQTEA 123


>BT006738-1|AAP35384.1|  157|Homo sapiens adaptor-related protein
           complex 1, sigma 2 subunit protein.
          Length = 157

 Score = 31.9 bits (69), Expect = 6.3
 Identities = 24/120 (20%), Positives = 51/120 (42%), Gaps = 6/120 (5%)

Query: 80  LVSRQFVEMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDKLYMLLITTKASN 139
           L  ++  ++T+  ++ +LA  PK+ +      F+E   ++ VY+    LY         N
Sbjct: 22  LSDKEKKKITRELVQTVLARKPKMCS------FLEWRDLKIVYKRYASLYFCCAIEDQDN 75

Query: 140 ILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRESVNLAQVRSFVE 199
            L  LE +  +  ++ +Y   + E +++       F  DE +  G  +  +   V   +E
Sbjct: 76  ELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIE 135


>BC071867-1|AAH71867.1|  157|Homo sapiens adaptor-related protein
           complex 1, sigma 2 subunit protein.
          Length = 157

 Score = 31.9 bits (69), Expect = 6.3
 Identities = 24/120 (20%), Positives = 51/120 (42%), Gaps = 6/120 (5%)

Query: 80  LVSRQFVEMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDKLYMLLITTKASN 139
           L  ++  ++T+  ++ +LA  PK+ +      F+E   ++ VY+    LY         N
Sbjct: 22  LSDKEKKKITRELVQTVLARKPKMCS------FLEWRDLKIVYKRYASLYFCCAIEDQDN 75

Query: 140 ILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRESVNLAQVRSFVE 199
            L  LE +  +  ++ +Y   + E +++       F  DE +  G  +  +   V   +E
Sbjct: 76  ELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIE 135


>BC001117-1|AAH01117.1|  157|Homo sapiens adaptor-related protein
           complex 1, sigma 2 subunit protein.
          Length = 157

 Score = 31.9 bits (69), Expect = 6.3
 Identities = 24/120 (20%), Positives = 51/120 (42%), Gaps = 6/120 (5%)

Query: 80  LVSRQFVEMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDKLYMLLITTKASN 139
           L  ++  ++T+  ++ +LA  PK+ +      F+E   ++ VY+    LY         N
Sbjct: 22  LSDKEKKKITRELVQTVLARKPKMCS------FLEWRDLKIVYKRYASLYFCCAIEDQDN 75

Query: 140 ILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRESVNLAQVRSFVE 199
            L  LE +  +  ++ +Y   + E +++       F  DE +  G  +  +   V   +E
Sbjct: 76  ELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIE 135


>AF251295-1|AAG44595.1|  181|Homo sapiens DC22 protein.
          Length = 181

 Score = 31.9 bits (69), Expect = 6.3
 Identities = 24/120 (20%), Positives = 51/120 (42%), Gaps = 6/120 (5%)

Query: 80  LVSRQFVEMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDKLYMLLITTKASN 139
           L  ++  ++T+  ++ +LA  PK+ +      F+E   ++ VY+    LY         N
Sbjct: 45  LSDKEKKKITRELVQTVLARKPKMCS------FLEWRDLKIVYKRYASLYFCCAIEDQDN 98

Query: 140 ILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRESVNLAQVRSFVE 199
            L  LE +  +  ++ +Y   + E +++       F  DE +  G  +  +   V   +E
Sbjct: 99  ELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIE 158


>AF087876-1|AAP97176.1|  157|Homo sapiens clathrin-associated
           protein 19 protein.
          Length = 157

 Score = 31.9 bits (69), Expect = 6.3
 Identities = 24/120 (20%), Positives = 51/120 (42%), Gaps = 6/120 (5%)

Query: 80  LVSRQFVEMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDKLYMLLITTKASN 139
           L  ++  ++T+  ++ +LA  PK+ +      F+E   ++ VY+    LY         N
Sbjct: 22  LSDKEKKKITRELVQTVLARKPKMCS------FLEWRDLKIVYKRYASLYFCCAIEDQDN 75

Query: 140 ILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRESVNLAQVRSFVE 199
            L  LE +  +  ++ +Y   + E +++       F  DE +  G  +  +   V   +E
Sbjct: 76  ELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIE 135


>AB015320-1|BAA33392.1|  157|Homo sapiens sigma1B subunit of AP-1
           clathrin adaptor complex protein.
          Length = 157

 Score = 31.9 bits (69), Expect = 6.3
 Identities = 24/120 (20%), Positives = 51/120 (42%), Gaps = 6/120 (5%)

Query: 80  LVSRQFVEMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDKLYMLLITTKASN 139
           L  ++  ++T+  ++ +LA  PK+ +      F+E   ++ VY+    LY         N
Sbjct: 22  LSDKEKKKITRELVQTVLARKPKMCS------FLEWRDLKIVYKRYASLYFCCAIEDQDN 75

Query: 140 ILEDLETLRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRESVNLAQVRSFVE 199
            L  LE +  +  ++ +Y   + E +++       F  DE +  G  +  +   V   +E
Sbjct: 76  ELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIE 135


>BX537780-1|CAD97839.1|  132|Homo sapiens hypothetical protein
           protein.
          Length = 132

 Score = 31.5 bits (68), Expect = 8.3
 Identities = 23/113 (20%), Positives = 48/113 (42%), Gaps = 6/113 (5%)

Query: 87  EMTKARIEGLLAAFPKLMTGGRQHTFVETESVRYVYQPLDKLYMLLITTKASNILEDLET 146
           ++T+  ++ +LA  PK+ +      F+E   ++ VY+    LY         N L  LE 
Sbjct: 5   KITRELVQTVLARKPKMCS------FLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEI 58

Query: 147 LRLFSRVVPEYCVQLTETEVLNQAFNLLFAFDEIVALGYRESVNLAQVRSFVE 199
           +  +  ++ +Y   + E +++       F  DE +  G  +  +   V   +E
Sbjct: 59  IHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIE 111


  Database: human
    Posted date:  Oct 5, 2007 11:13 AM
  Number of letters in database: 73,234,838
  Number of sequences in database:  224,733
  
Lambda     K      H
   0.317    0.133    0.385 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 75,778,776
Number of Sequences: 224733
Number of extensions: 3108012
Number of successful extensions: 8155
Number of sequences better than 10.0: 44
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 8115
Number of HSP's gapped (non-prelim): 44
length of query: 571
length of database: 73,234,838
effective HSP length: 94
effective length of query: 477
effective length of database: 52,109,936
effective search space: 24856439472
effective search space used: 24856439472
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 68 (31.5 bits)

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