Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000072-TA|BGIBMGA000072-PA|IPR000408|Regulator of
chromosome condensation, RCC1, IPR009091|Regulator of chromosome
condensation/beta-lactamase-inhibitor protein II
(506 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC069198-1|AAH69198.1| 452|Homo sapiens regulator of chromosome... 318 3e-86
X12654-1|CAA31182.1| 421|Homo sapiens protein ( Human mRNA for ... 318 4e-86
X06130-1|CAA29496.1| 421|Homo sapiens protein ( Human mRNA for ... 318 4e-86
D00591-1|BAA00469.1| 421|Homo sapiens RCC1 protein. 318 4e-86
CR407693-1|CAG28621.1| 421|Homo sapiens CHC1 protein. 318 4e-86
BC036903-1|AAH36903.1| 421|Homo sapiens regulator of chromosome... 318 4e-86
BC010067-1|AAH10067.1| 421|Homo sapiens regulator of chromosome... 318 4e-86
BC007300-1|AAH07300.1| 421|Homo sapiens regulator of chromosome... 318 4e-86
AL513497-2|CAI22287.1| 421|Homo sapiens regulator of chromosome... 318 4e-86
AF498924-1|AAM21072.1| 421|Homo sapiens regulator of chromosome... 318 4e-86
BC039600-1|AAH39600.1| 1049|Homo sapiens hect domain and RLD 4 p... 133 2e-30
AY650033-1|AAV66579.1| 979|Homo sapiens HECT and RCC1 containin... 133 2e-30
AY221963-1|AAO65480.1| 1057|Homo sapiens HECT and RCC1 containin... 133 2e-30
AL356741-3|CAH74148.1| 1049|Homo sapiens hect domain and RLD 4 p... 133 2e-30
AL133551-3|CAI16032.1| 1049|Homo sapiens hect domain and RLD 4 p... 133 2e-30
U50078-1|AAD12586.1| 4861|Homo sapiens p532 protein. 123 2e-27
AF071172-1|AAD08657.1| 4834|Homo sapiens HERC2 protein. 122 4e-27
D25215-1|BAA04945.2| 1054|Homo sapiens KIAA0032 protein. 121 7e-27
BC038960-1|AAH38960.1| 368|Homo sapiens HERC3 protein protein. 120 1e-26
AC098582-1|AAY41038.1| 382|Homo sapiens unknown protein. 120 1e-26
AJ318463-1|CAC86116.1| 815|Homo sapiens retinitis pigmentosa GT... 97 2e-19
X97668-1|CAA66258.1| 815|Homo sapiens XLRP3 protein. 96 2e-19
U57629-1|AAC50481.1| 815|Homo sapiens retinitis pigmentosa GTPa... 96 2e-19
BC031624-1|AAH31624.1| 480|Homo sapiens RPGR protein protein. 96 2e-19
AL606748-2|CAI95407.1| 815|Homo sapiens retinitis pigmentosa GT... 96 2e-19
AK223491-1|BAD97211.1| 815|Homo sapiens retinitis pigmentosa GT... 96 2e-19
AJ238395-1|CAB54002.1| 646|Homo sapiens RPGR protein protein. 96 2e-19
AF225407-1|AAO27483.1| 409|Homo sapiens HERC2 protein. 94 1e-18
AF224249-1|AAO27475.1| 328|Homo sapiens HERC2 protein. 93 2e-18
BC042047-1|AAH42047.2| 1022|Homo sapiens hect domain and RLD 6 p... 91 1e-17
AY653203-1|AAV66897.1| 322|Homo sapiens truncated HERC6 protein. 91 1e-17
AY653202-1|AAV66896.1| 364|Homo sapiens truncated HERC6 protein. 91 1e-17
AY653201-1|AAV66895.1| 986|Homo sapiens HERC6 splice variant pr... 91 1e-17
AF336798-1|AAQ14893.1| 1022|Homo sapiens HERC6 protein. 91 1e-17
BC112101-1|AAI12102.1| 979|Homo sapiens NIMA related kinase 9 p... 90 2e-17
BC093881-1|AAH93881.1| 979|Homo sapiens NIMA (never in mitosis ... 90 2e-17
AY080896-1|AAL87410.1| 979|Homo sapiens NIMA-family kinase NERC... 90 2e-17
AY048580-1|AAL05428.1| 979|Homo sapiens NIMA-related kinase Nek... 90 2e-17
AC007055-4|AAD31939.1| 414|Homo sapiens protein ( Homo sapiens ... 90 2e-17
AB082526-1|BAC02704.1| 1011|Homo sapiens KIAA1995 protein protein. 90 2e-17
BC029052-1|AAH29052.1| 551|Homo sapiens regulator of chromosome... 89 3e-17
AY341245-1|AAP88928.1| 551|Homo sapiens chromosome condensation... 89 3e-17
AL157813-1|CAH70795.1| 551|Homo sapiens regulator of chromosome... 89 3e-17
AF060219-1|AAC79987.1| 551|Homo sapiens RCC1-like G exchanging ... 89 3e-17
AB209543-1|BAD92780.1| 556|Homo sapiens RCC1-like G exchanging ... 89 3e-17
BC038104-1|AAH38104.1| 355|Homo sapiens RCBTB1 protein protein. 87 1e-16
AL139321-5|CAH71047.1| 531|Homo sapiens regulator of chromosome... 87 2e-16
AK096654-1|BAC04833.1| 531|Homo sapiens protein ( Homo sapiens ... 87 2e-16
AJ319660-1|CAC40027.1| 531|Homo sapiens guanine nucleotide exch... 87 2e-16
AF334406-1|AAK38372.1| 531|Homo sapiens CLLL7 protein protein. 87 2e-16
AB027289-1|BAA88519.1| 1024|Homo sapiens cyclin-E binding protei... 87 2e-16
AY337518-1|AAR00320.1| 1024|Homo sapiens HECT E3 ubiquitin ligas... 86 3e-16
BC065375-1|AAH65375.1| 458|Homo sapiens secretion regulating gu... 84 1e-15
AJ243950-1|CAB60832.1| 458|Homo sapiens deafness locus associat... 84 1e-15
BC113705-1|AAI13706.1| 692|Homo sapiens NIMA (never in mitosis ... 84 1e-15
BC112240-1|AAI12241.1| 692|Homo sapiens NIMA-related kinase 8 p... 84 1e-15
AY267371-1|AAP04006.1| 692|Homo sapiens NIMA-family kinase NEK8... 84 1e-15
AY242354-1|AAO88243.1| 692|Homo sapiens NIMA-related kinase 12a... 84 1e-15
BC053908-1|AAH53908.1| 522|Homo sapiens RCC2 protein protein. 83 2e-15
BC042141-1|AAH42141.1| 522|Homo sapiens regulator of chromosome... 83 2e-15
AJ421269-1|CAD13148.1| 522|Homo sapiens RCC1-like protein protein. 83 2e-15
AB040903-1|BAA95994.1| 564|Homo sapiens KIAA1470 protein protein. 83 2e-15
AL359612-1|CAB94882.1| 333|Homo sapiens hypothetical protein pr... 82 4e-15
AB046813-1|BAB13419.1| 953|Homo sapiens KIAA1593 protein protein. 80 2e-14
AL356741-1|CAH74146.1| 907|Homo sapiens hect domain and RLD 4 p... 76 3e-13
AL133551-1|CAI16031.1| 907|Homo sapiens hect domain and RLD 4 p... 76 3e-13
BC040929-1|AAH40929.1| 651|Homo sapiens HERC1 protein protein. 73 3e-12
BC004933-1|AAH04933.1| 351|Homo sapiens RCC2 protein protein. 73 3e-12
AJ243951-1|CAB60833.1| 288|Homo sapiens deafness locus associat... 69 4e-11
AF225404-1|AAO27482.1| 259|Homo sapiens HERC2 protein. 68 7e-11
AK092403-1|BAC03879.1| 184|Homo sapiens protein ( Homo sapiens ... 65 5e-10
AC004460-2|AAC06339.1| 371|Homo sapiens WUGSC:H_DJ1086D14.2 pro... 62 6e-09
BC019008-1|AAH19008.1| 464|Homo sapiens Williams-Beuren syndrom... 59 3e-08
BC007823-1|AAH07823.1| 464|Homo sapiens Williams-Beuren syndrom... 59 3e-08
AF410455-1|AAM62304.1| 464|Homo sapiens RCC1-like G exchanging ... 59 3e-08
DQ005634-1|AAY55907.1| 1196|Homo sapiens inhibitor of Bruton's t... 58 7e-08
DQ005633-1|AAY55906.1| 1353|Homo sapiens inhibitor of Bruton's t... 58 7e-08
BC113698-1|AAI13699.1| 1353|Homo sapiens inhibitor of Bruton aga... 58 7e-08
BC113696-1|AAI13697.1| 1353|Homo sapiens inhibitor of Bruton aga... 58 7e-08
AL050333-2|CAI23416.1| 1187|Homo sapiens RP1-93K22.1 protein. 58 7e-08
AB037838-1|BAA92655.2| 1379|Homo sapiens KIAA1417 protein protein. 58 7e-08
BC040695-1|AAH40695.1| 358|Homo sapiens WBSCR16 protein protein. 56 3e-07
BC032712-1|AAH32712.1| 454|Homo sapiens WBSCR16 protein protein. 56 3e-07
AL359257-2|CAI39759.1| 4640|Homo sapiens AC001226.5 protein. 53 2e-06
AL159158-1|CAI16842.1| 4640|Homo sapiens AC001226.5 protein. 53 2e-06
AL159154-1|CAH73736.1| 4640|Homo sapiens AC001226.5 protein. 53 2e-06
AF075587-1|AAC39928.1| 4641|Homo sapiens protein associated with... 53 2e-06
BC071576-1|AAH71576.1| 1237|Homo sapiens ALS2 protein protein. 53 3e-06
AB053306-1|BAB69015.1| 396|Homo sapiens ALS2 protein. 53 3e-06
AB053305-1|BAB69014.1| 1657|Homo sapiens ALS2 protein. 53 3e-06
AB046783-1|BAB13389.2| 1658|Homo sapiens KIAA1563 protein protein. 53 3e-06
AK023024-1|BAB14362.1| 396|Homo sapiens protein ( Homo sapiens ... 52 5e-06
AF391100-1|AAL14103.1| 1657|Homo sapiens alsin protein. 52 5e-06
BC113826-1|AAI13827.1| 244|Homo sapiens RCCD1 protein protein. 51 1e-05
BC029174-1|AAH29174.1| 812|Homo sapiens ALS2 protein protein. 51 1e-05
AC007279-1|AAY15058.1| 1598|Homo sapiens unknown protein. 51 1e-05
AY650034-1|AAV66580.1| 110|Homo sapiens HECT and RCC1 containin... 48 8e-05
AY650032-1|AAV66578.1| 117|Homo sapiens HECT and RCC1 containin... 48 8e-05
BC067293-1|AAH67293.1| 580|Homo sapiens F-box protein 24 protein. 38 0.083
AC069281-1|AAP21863.1| 580|Homo sapiens unknown protein. 38 0.083
BC113035-1|AAI13036.1| 140|Homo sapiens FSD1L protein protein. 34 1.0
BC105053-1|AAI05054.1| 643|Homo sapiens praja 1 protein. 32 4.1
BC105051-1|AAI05052.1| 643|Homo sapiens praja 1 protein. 32 4.1
BC075803-1|AAH75803.1| 643|Homo sapiens praja 1 protein. 32 4.1
AL157699-2|CAI41604.1| 643|Homo sapiens praja 1 protein. 32 4.1
AL157699-1|CAM24741.1| 588|Homo sapiens praja 1 protein. 32 4.1
AF262024-1|AAM53039.1| 643|Homo sapiens PJA1 protein. 32 4.1
AF026547-1|AAC80576.1| 1321|Homo sapiens neurocan protein. 31 7.2
AC003110-2|AAB86655.1| 990|Homo sapiens PGCN_HUMAN protein. 31 7.2
AB210004-1|BAE06086.1| 1335|Homo sapiens CSPG3 variant protein p... 31 7.2
BC009336-1|AAH09336.2| 326|Homo sapiens NEK9 protein protein. 31 9.5
>BC069198-1|AAH69198.1| 452|Homo sapiens regulator of chromosome
condensation 1 protein.
Length = 452
Score = 318 bits (781), Expect = 3e-86
Identities = 177/416 (42%), Positives = 247/416 (59%), Gaps = 25/416 (6%)
Query: 23 PKNKKKRGAIQLEIPTAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDV 82
P ++K R T P G VLT GQGDVGQLGLGE+V+E K V+ + + +V
Sbjct: 48 PPDQKTRPVSHRSHSTEP---GLVLTLGQGDVGQLGLGENVMERKKPALVS-IPEDVVQA 103
Query: 83 QAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSA 142
+AGGMHT+ L SG++++FGCNDEGALGR TS E E P + GDSH+A
Sbjct: 104 EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTA 163
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
AL +G V+ WGSFRD++G +GL+ K PV++ + P V++ASG DHLV+LT
Sbjct: 164 ALTDDGRVFLWGSFRDNNGVIGLL---EPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTA 220
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAAR-------VWAGH 255
G ++TLGCGEQGQLGR+ + A+R RQG LLVP V L+ +R + G
Sbjct: 221 DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA 280
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ TF + + ++ FGL+NY QLG G + + F P + + +W + GQ
Sbjct: 281 YFTFAI-SHEGHVYGFGLSNYHQLGTPGTE---SCFIPQNLTSFK--NSTKSWVGFSGGQ 334
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
HHT+ + + G+ Y+LGR EYGRLGLG+ + + LI +L S+A G S +AVT
Sbjct: 335 HHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVT 392
Query: 376 DSGEVYSWGMGSEGKLGTGESEDLNEPTL---AAVDSRAPLRVSAGGQHTVLLVEE 428
G V++WGMG+ +LGTG+ ED P +++R L VS+GGQHTVLLV++
Sbjct: 393 KDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 448
>X12654-1|CAA31182.1| 421|Homo sapiens protein ( Human mRNA for
cell cycle gene RCC1. ).
Length = 421
Score = 318 bits (780), Expect = 4e-86
Identities = 176/416 (42%), Positives = 250/416 (60%), Gaps = 26/416 (6%)
Query: 23 PKNKKKRGAIQLEIPTAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDV 82
PK+KK +++ + + G VLT GQGDVGQLGLGE+V+E K V+ + + +V
Sbjct: 18 PKSKK----VKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS-IPEDVVQA 72
Query: 83 QAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSA 142
+AGGMHT+ L SG++++FGCNDEGALGR TS E E P + GDSH+A
Sbjct: 73 EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTA 132
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
AL +G V+ WGSFRD++G +GL+ K PV++ + P V++ASG DHLV+LT
Sbjct: 133 ALTDDGRVFLWGSFRDNNGVIGLL---EPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTA 189
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAAR-------VWAGH 255
G ++TLGCGEQGQLGR+ + A+R RQG LLVP V L+ +R + G
Sbjct: 190 DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA 249
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ TF + + ++ FGL+NY QLG G + + F P + + +W + GQ
Sbjct: 250 YFTFAI-SHEGHVYGFGLSNYHQLGTPGTE---SCFIPQNLTSFK--NSTKSWVGFSGGQ 303
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
HHT+ + + G+ Y+LGR EYGRLGLG+ + + LI +L S+A G S +AVT
Sbjct: 304 HHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVT 361
Query: 376 DSGEVYSWGMGSEGKLGTGESEDLNEPTL---AAVDSRAPLRVSAGGQHTVLLVEE 428
G V++WGMG+ +LGTG+ ED P +++R L VS+GGQHTVLLV++
Sbjct: 362 KDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417
>X06130-1|CAA29496.1| 421|Homo sapiens protein ( Human mRNA for
cell cycle gene RCC1. ).
Length = 421
Score = 318 bits (780), Expect = 4e-86
Identities = 176/416 (42%), Positives = 250/416 (60%), Gaps = 26/416 (6%)
Query: 23 PKNKKKRGAIQLEIPTAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDV 82
PK+KK +++ + + G VLT GQGDVGQLGLGE+V+E K V+ + + +V
Sbjct: 18 PKSKK----VKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS-IPEDVVQA 72
Query: 83 QAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSA 142
+AGGMHT+ L SG++++FGCNDEGALGR TS E E P + GDSH+A
Sbjct: 73 EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTA 132
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
AL +G V+ WGSFRD++G +GL+ K PV++ + P V++ASG DHLV+LT
Sbjct: 133 ALTDDGRVFLWGSFRDNNGVIGLL---EPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTA 189
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAAR-------VWAGH 255
G ++TLGCGEQGQLGR+ + A+R RQG LLVP V L+ +R + G
Sbjct: 190 DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA 249
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ TF + + ++ FGL+NY QLG G + + F P + + +W + GQ
Sbjct: 250 YFTFAI-SHEGHVYGFGLSNYHQLGTPGTE---SCFIPQNLTSFK--NSTKSWVGFSGGQ 303
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
HHT+ + + G+ Y+LGR EYGRLGLG+ + + LI +L S+A G S +AVT
Sbjct: 304 HHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVT 361
Query: 376 DSGEVYSWGMGSEGKLGTGESEDLNEPTL---AAVDSRAPLRVSAGGQHTVLLVEE 428
G V++WGMG+ +LGTG+ ED P +++R L VS+GGQHTVLLV++
Sbjct: 362 KDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417
>D00591-1|BAA00469.1| 421|Homo sapiens RCC1 protein.
Length = 421
Score = 318 bits (780), Expect = 4e-86
Identities = 176/416 (42%), Positives = 250/416 (60%), Gaps = 26/416 (6%)
Query: 23 PKNKKKRGAIQLEIPTAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDV 82
PK+KK +++ + + G VLT GQGDVGQLGLGE+V+E K V+ + + +V
Sbjct: 18 PKSKK----VKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS-IPEDVVQA 72
Query: 83 QAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSA 142
+AGGMHT+ L SG++++FGCNDEGALGR TS E E P + GDSH+A
Sbjct: 73 EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTA 132
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
AL +G V+ WGSFRD++G +GL+ K PV++ + P V++ASG DHLV+LT
Sbjct: 133 ALTDDGRVFLWGSFRDNNGVIGLL---EPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTA 189
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAAR-------VWAGH 255
G ++TLGCGEQGQLGR+ + A+R RQG LLVP V L+ +R + G
Sbjct: 190 DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA 249
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ TF + + ++ FGL+NY QLG G + + F P + + +W + GQ
Sbjct: 250 YFTFAI-SHEGHVYGFGLSNYHQLGTPGTE---SCFIPQNLTSFK--NSTKSWVGFSGGQ 303
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
HHT+ + + G+ Y+LGR EYGRLGLG+ + + LI +L S+A G S +AVT
Sbjct: 304 HHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVT 361
Query: 376 DSGEVYSWGMGSEGKLGTGESEDLNEPTL---AAVDSRAPLRVSAGGQHTVLLVEE 428
G V++WGMG+ +LGTG+ ED P +++R L VS+GGQHTVLLV++
Sbjct: 362 KDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417
>CR407693-1|CAG28621.1| 421|Homo sapiens CHC1 protein.
Length = 421
Score = 318 bits (780), Expect = 4e-86
Identities = 176/416 (42%), Positives = 250/416 (60%), Gaps = 26/416 (6%)
Query: 23 PKNKKKRGAIQLEIPTAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDV 82
PK+KK +++ + + G VLT GQGDVGQLGLGE+V+E K V+ + + +V
Sbjct: 18 PKSKK----VKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS-IPEDVVQA 72
Query: 83 QAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSA 142
+AGGMHT+ L SG++++FGCNDEGALGR TS E E P + GDSH+A
Sbjct: 73 EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTA 132
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
AL +G V+ WGSFRD++G +GL+ K PV++ + P V++ASG DHLV+LT
Sbjct: 133 ALTDDGRVFLWGSFRDNNGVIGLL---EPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTA 189
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAAR-------VWAGH 255
G ++TLGCGEQGQLGR+ + A+R RQG LLVP V L+ +R + G
Sbjct: 190 DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA 249
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ TF + + ++ FGL+NY QLG G + + F P + + +W + GQ
Sbjct: 250 YFTFAI-SHEGHVYGFGLSNYHQLGTPGTE---SCFIPQNLTSFK--NSTKSWVGFSGGQ 303
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
HHT+ + + G+ Y+LGR EYGRLGLG+ + + LI +L S+A G S +AVT
Sbjct: 304 HHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVT 361
Query: 376 DSGEVYSWGMGSEGKLGTGESEDLNEPTL---AAVDSRAPLRVSAGGQHTVLLVEE 428
G V++WGMG+ +LGTG+ ED P +++R L VS+GGQHTVLLV++
Sbjct: 362 KDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417
>BC036903-1|AAH36903.1| 421|Homo sapiens regulator of chromosome
condensation 1 protein.
Length = 421
Score = 318 bits (780), Expect = 4e-86
Identities = 176/416 (42%), Positives = 250/416 (60%), Gaps = 26/416 (6%)
Query: 23 PKNKKKRGAIQLEIPTAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDV 82
PK+KK +++ + + G VLT GQGDVGQLGLGE+V+E K V+ + + +V
Sbjct: 18 PKSKK----VKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS-IPEDVVQA 72
Query: 83 QAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSA 142
+AGGMHT+ L SG++++FGCNDEGALGR TS E E P + GDSH+A
Sbjct: 73 EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTA 132
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
AL +G V+ WGSFRD++G +GL+ K PV++ + P V++ASG DHLV+LT
Sbjct: 133 ALTDDGRVFLWGSFRDNNGVIGLL---EPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTA 189
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAAR-------VWAGH 255
G ++TLGCGEQGQLGR+ + A+R RQG LLVP V L+ +R + G
Sbjct: 190 DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA 249
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ TF + + ++ FGL+NY QLG G + + F P + + +W + GQ
Sbjct: 250 YFTFAI-SHEGHVYGFGLSNYHQLGTPGTE---SCFIPQNLTSFK--NSTKSWVGFSGGQ 303
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
HHT+ + + G+ Y+LGR EYGRLGLG+ + + LI +L S+A G S +AVT
Sbjct: 304 HHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVT 361
Query: 376 DSGEVYSWGMGSEGKLGTGESEDLNEPTL---AAVDSRAPLRVSAGGQHTVLLVEE 428
G V++WGMG+ +LGTG+ ED P +++R L VS+GGQHTVLLV++
Sbjct: 362 KDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417
>BC010067-1|AAH10067.1| 421|Homo sapiens regulator of chromosome
condensation 1 protein.
Length = 421
Score = 318 bits (780), Expect = 4e-86
Identities = 176/416 (42%), Positives = 250/416 (60%), Gaps = 26/416 (6%)
Query: 23 PKNKKKRGAIQLEIPTAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDV 82
PK+KK +++ + + G VLT GQGDVGQLGLGE+V+E K V+ + + +V
Sbjct: 18 PKSKK----VKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS-IPEDVVQA 72
Query: 83 QAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSA 142
+AGGMHT+ L SG++++FGCNDEGALGR TS E E P + GDSH+A
Sbjct: 73 EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTA 132
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
AL +G V+ WGSFRD++G +GL+ K PV++ + P V++ASG DHLV+LT
Sbjct: 133 ALTDDGRVFLWGSFRDNNGVIGLL---EPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTA 189
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAAR-------VWAGH 255
G ++TLGCGEQGQLGR+ + A+R RQG LLVP V L+ +R + G
Sbjct: 190 DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA 249
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ TF + + ++ FGL+NY QLG G + + F P + + +W + GQ
Sbjct: 250 YFTFAI-SHEGHVYGFGLSNYHQLGTPGTE---SCFIPQNLTSFK--NSTKSWVGFSGGQ 303
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
HHT+ + + G+ Y+LGR EYGRLGLG+ + + LI +L S+A G S +AVT
Sbjct: 304 HHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVT 361
Query: 376 DSGEVYSWGMGSEGKLGTGESEDLNEPTL---AAVDSRAPLRVSAGGQHTVLLVEE 428
G V++WGMG+ +LGTG+ ED P +++R L VS+GGQHTVLLV++
Sbjct: 362 KDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417
>BC007300-1|AAH07300.1| 421|Homo sapiens regulator of chromosome
condensation 1 protein.
Length = 421
Score = 318 bits (780), Expect = 4e-86
Identities = 176/416 (42%), Positives = 250/416 (60%), Gaps = 26/416 (6%)
Query: 23 PKNKKKRGAIQLEIPTAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDV 82
PK+KK +++ + + G VLT GQGDVGQLGLGE+V+E K V+ + + +V
Sbjct: 18 PKSKK----VKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS-IPEDVVQA 72
Query: 83 QAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSA 142
+AGGMHT+ L SG++++FGCNDEGALGR TS E E P + GDSH+A
Sbjct: 73 EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTA 132
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
AL +G V+ WGSFRD++G +GL+ K PV++ + P V++ASG DHLV+LT
Sbjct: 133 ALTDDGRVFLWGSFRDNNGVIGLL---EPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTA 189
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAAR-------VWAGH 255
G ++TLGCGEQGQLGR+ + A+R RQG LLVP V L+ +R + G
Sbjct: 190 DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA 249
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ TF + + ++ FGL+NY QLG G + + F P + + +W + GQ
Sbjct: 250 YFTFAI-SHEGHVYGFGLSNYHQLGTPGTE---SCFIPQNLTSFK--NSTKSWVGFSGGQ 303
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
HHT+ + + G+ Y+LGR EYGRLGLG+ + + LI +L S+A G S +AVT
Sbjct: 304 HHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVT 361
Query: 376 DSGEVYSWGMGSEGKLGTGESEDLNEPTL---AAVDSRAPLRVSAGGQHTVLLVEE 428
G V++WGMG+ +LGTG+ ED P +++R L VS+GGQHTVLLV++
Sbjct: 362 KDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417
>AL513497-2|CAI22287.1| 421|Homo sapiens regulator of chromosome
condensation 1 protein.
Length = 421
Score = 318 bits (780), Expect = 4e-86
Identities = 176/416 (42%), Positives = 250/416 (60%), Gaps = 26/416 (6%)
Query: 23 PKNKKKRGAIQLEIPTAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDV 82
PK+KK +++ + + G VLT GQGDVGQLGLGE+V+E K V+ + + +V
Sbjct: 18 PKSKK----VKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS-IPEDVVQA 72
Query: 83 QAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSA 142
+AGGMHT+ L SG++++FGCNDEGALGR TS E E P + GDSH+A
Sbjct: 73 EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTA 132
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
AL +G V+ WGSFRD++G +GL+ K PV++ + P V++ASG DHLV+LT
Sbjct: 133 ALTDDGRVFLWGSFRDNNGVIGLL---EPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTA 189
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAAR-------VWAGH 255
G ++TLGCGEQGQLGR+ + A+R RQG LLVP V L+ +R + G
Sbjct: 190 DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA 249
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ TF + + ++ FGL+NY QLG G + + F P + + +W + GQ
Sbjct: 250 YFTFAI-SHEGHVYGFGLSNYHQLGTPGTE---SCFIPQNLTSFK--NSTKSWVGFSGGQ 303
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
HHT+ + + G+ Y+LGR EYGRLGLG+ + + LI +L S+A G S +AVT
Sbjct: 304 HHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVT 361
Query: 376 DSGEVYSWGMGSEGKLGTGESEDLNEPTL---AAVDSRAPLRVSAGGQHTVLLVEE 428
G V++WGMG+ +LGTG+ ED P +++R L VS+GGQHTVLLV++
Sbjct: 362 KDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417
>AF498924-1|AAM21072.1| 421|Homo sapiens regulator of chromosome
condensation 1 protein.
Length = 421
Score = 318 bits (780), Expect = 4e-86
Identities = 176/416 (42%), Positives = 250/416 (60%), Gaps = 26/416 (6%)
Query: 23 PKNKKKRGAIQLEIPTAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDV 82
PK+KK +++ + + G VLT GQGDVGQLGLGE+V+E K V+ + + +V
Sbjct: 18 PKSKK----VKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS-IPEDVVQA 72
Query: 83 QAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSA 142
+AGGMHT+ L SG++++FGCNDEGALGR TS E E P + GDSH+A
Sbjct: 73 EAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTA 132
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
AL +G V+ WGSFRD++G +GL+ K PV++ + P V++ASG DHLV+LT
Sbjct: 133 ALTDDGRVFLWGSFRDNNGVIGLL---EPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTA 189
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAAR-------VWAGH 255
G ++TLGCGEQGQLGR+ + A+R RQG LLVP V L+ +R + G
Sbjct: 190 DGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGA 249
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ TF + + ++ FGL+NY QLG G + + F P + + +W + GQ
Sbjct: 250 YFTFAI-SHEGHVYGFGLSNYHQLGTPGTE---SCFIPQNLTSFK--NSTKSWVGFSGGQ 303
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
HHT+ + + G+ Y+LGR EYGRLGLG+ + + LI +L S+A G S +AVT
Sbjct: 304 HHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAVSSVACGASVGYAVT 361
Query: 376 DSGEVYSWGMGSEGKLGTGESEDLNEPTL---AAVDSRAPLRVSAGGQHTVLLVEE 428
G V++WGMG+ +LGTG+ ED P +++R L VS+GGQHTVLLV++
Sbjct: 362 KDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417
>BC039600-1|AAH39600.1| 1049|Homo sapiens hect domain and RLD 4
protein.
Length = 1049
Score = 133 bits (321), Expect = 2e-30
Identities = 112/362 (30%), Positives = 164/362 (45%), Gaps = 29/362 (8%)
Query: 46 VLTCGQGDVGQLGLG----EDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+L G GQLGLG E V+E K + + ++ DV G HT+ + G ++T
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF--INKRVRDVGCGLRHTVFVLDDGTVYTC 58
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
GCND G LG S +K E G++H+ AL G VYAWG DS G
Sbjct: 59 GCNDLGQLGHEKSRKKPEQV--VALDAQNIVAVSCGEAHTLALNDKGQVYAWG--LDSDG 114
Query: 162 SMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLA 221
+GL V E +K V++A G H + L+ + VF G + GQLG L
Sbjct: 115 QLGL-VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG-LG 172
Query: 222 QRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGI 281
+ + Q +LL + Q AA G H +FVL A +F +G N +GQLG+
Sbjct: 173 TDCKKQTSPQLLKSLL---GIPFMQVAA---GGAH-SFVLTLSGA-IFGWGRNKFGQLGL 224
Query: 282 TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLG 341
E + + P +LR+ + G+ HT L G ++ G YG+LG
Sbjct: 225 NDENDR---YVPNLLKSLRS----QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 342 DKSGDAETLELIPKLQNKKCISIAAGTSNSFA-VTDSGEVYSWGMGSEGKLGTGESEDLN 400
S + ++ +L IA G ++ A V SG +YS+G+G G+LGTG + +
Sbjct: 278 STSHEINPRKVF-ELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336
Query: 401 EP 402
P
Sbjct: 337 SP 338
Score = 98.3 bits (234), Expect = 6e-20
Identities = 81/279 (29%), Positives = 131/279 (46%), Gaps = 25/279 (8%)
Query: 153 WGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLG 210
WG+ S G +GL G + + EP K D I + ++ G H V + G V+T G
Sbjct: 4 WGNA--SFGQLGL--GGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCG 59
Query: 211 CGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFA 270
C + GQLG SR + AL Q V G T L+ + +++A
Sbjct: 60 CNDLGQLGH----EKSRKKPEQVVALDA-------QNIVAVSCGEAHTLALNDK-GQVYA 107
Query: 271 FGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYAL 330
+GL++ GQLG+ G + + P +L D VA G +H+L L+ +++
Sbjct: 108 WGLDSDGQLGLVGSEE--CIRVPRNIKSL----SDIQIVQVACGYYHSLALSKASEVFCW 161
Query: 331 GRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGK 390
G+ +YG+LGLG + +L+ L + +AAG ++SF +T SG ++ WG G+
Sbjct: 162 GQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQ 221
Query: 391 LGTGESEDLNEPT-LAAVDSRAPLRVSAGGQHTVLLVEE 428
LG + D P L ++ S+ + + G HT L +E
Sbjct: 222 LGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKE 260
Score = 97.9 bits (233), Expect = 7e-20
Identities = 91/307 (29%), Positives = 138/307 (44%), Gaps = 32/307 (10%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTFG 102
G V TCG D+GQLG + K + V AL IV V G HT+AL+ G+++ +G
Sbjct: 53 GTVYTCGCNDLGQLGHEK---SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWG 109
Query: 103 CNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
+ +G LG S E P+ + G HS AL + +V+ WG ++ +
Sbjct: 110 LDSDGQLGLVGSEECIR-VPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWG--QNKY 166
Query: 161 GSMGLVVRGREGKPCKEP--VKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLG 218
G +GL G + K P +K +G P +++A+GG H VLT SG +F G + GQLG
Sbjct: 167 GQLGL---GTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLG 223
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
D + L+ + Q + G T L + +F FG YGQ
Sbjct: 224 -------LNDENDRYVPNLL--KSLRSQKIVYICCGEDHTAAL-TKEGGVFTFGAGGYGQ 273
Query: 279 LGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT-LAANGQIYALGRCEYGR 337
LG + +P + L + +A G+ HT + ++G+IY+ G G+
Sbjct: 274 LGHNSTSHE---INPRKVFELMG----SIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQ 326
Query: 338 LGLGDKS 344
LG G S
Sbjct: 327 LGTGSTS 333
Score = 84.2 bits (199), Expect = 1e-15
Identities = 73/255 (28%), Positives = 115/255 (45%), Gaps = 21/255 (8%)
Query: 43 RGRVLTCGQGDVGQLGL--GEDVVETTKFKYVTALGD-KIVDVQAGGMHTIALDSSGKIW 99
+G+V G GQLGL E+ + + + +L D +IV V G H++AL + +++
Sbjct: 102 KGQVYAWGLDSDGQLGLVGSEECIRVPR--NIKSLSDIQIVQVACGYYHSLALSKASEVF 159
Query: 100 TFGCNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
+G N G LG T +K + +P+ + G +HS L +G ++ WG R
Sbjct: 160 CWGQNKYGQLGLGTDCKK-QTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWG--R 216
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQL 217
+ G +GL + +K + V I G DH LT GGVFT G G GQL
Sbjct: 217 NKFGQLGL--NDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274
Query: 218 GRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYG 277
G + S + R+ F + + A R H + FV + R+++FGL G
Sbjct: 275 GHNST-SHEINPRKVFELM---GSIVTEIACGRQ---HTSAFVPSS--GRIYSFGLGGNG 325
Query: 278 QLGITGEKRKTALFS 292
QLG + + F+
Sbjct: 326 QLGTGSTSNRKSPFT 340
Score = 77.8 bits (183), Expect = 8e-14
Identities = 58/182 (31%), Positives = 83/182 (45%), Gaps = 6/182 (3%)
Query: 39 APKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYV-TALGDKIVDVQAGGMHTIALDSSGK 97
A K V GQ GQLGLG D + T + + + LG + V AGG H+ L SG
Sbjct: 151 ALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGA 210
Query: 98 IWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
I+ +G N G LG N++ + G+ H+AAL + G V+ +G+
Sbjct: 211 IFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGA-- 268
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHL-VVLTTSGGVFTLGCGEQGQ 216
+G +G E P K V +G EIA G H + +SG +++ G G GQ
Sbjct: 269 GGYGQLGHNSTSHEINPRK--VFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQ 326
Query: 217 LG 218
LG
Sbjct: 327 LG 328
Score = 52.0 bits (119), Expect = 5e-06
Identities = 32/84 (38%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIA-LDSSGKIWT 100
K G V T G G GQLG E K +G + ++ G HT A + SSG+I++
Sbjct: 259 KEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYS 318
Query: 101 FGCNDEGALGR-ATSNEKDEGTPK 123
FG G LG +TSN K T K
Sbjct: 319 FGLGGNGQLGTGSTSNRKSPFTVK 342
>AY650033-1|AAV66579.1| 979|Homo sapiens HECT and RCC1 containing
protein 4 isoform 3 protein.
Length = 979
Score = 133 bits (321), Expect = 2e-30
Identities = 112/362 (30%), Positives = 164/362 (45%), Gaps = 29/362 (8%)
Query: 46 VLTCGQGDVGQLGLG----EDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+L G GQLGLG E V+E K + + ++ DV G HT+ + G ++T
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF--INKRVRDVGCGLRHTVFVLDDGTVYTC 58
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
GCND G LG S +K E G++H+ AL G VYAWG DS G
Sbjct: 59 GCNDLGQLGHEKSRKKPEQV--VALDAQNIVAVSCGEAHTLALNDKGQVYAWG--LDSDG 114
Query: 162 SMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLA 221
+GL V E +K V++A G H + L+ + VF G + GQLG L
Sbjct: 115 QLGL-VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG-LG 172
Query: 222 QRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGI 281
+ + Q +LL + Q AA G H +FVL A +F +G N +GQLG+
Sbjct: 173 TDCKKQTSPQLLKSLL---GIPFMQVAA---GGAH-SFVLTLSGA-IFGWGRNKFGQLGL 224
Query: 282 TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLG 341
E + + P +LR+ + G+ HT L G ++ G YG+LG
Sbjct: 225 NDENDR---YVPNLLKSLRS----QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 342 DKSGDAETLELIPKLQNKKCISIAAGTSNSFA-VTDSGEVYSWGMGSEGKLGTGESEDLN 400
S + ++ +L IA G ++ A V SG +YS+G+G G+LGTG + +
Sbjct: 278 STSHEINPRKVF-ELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336
Query: 401 EP 402
P
Sbjct: 337 SP 338
Score = 98.3 bits (234), Expect = 6e-20
Identities = 81/279 (29%), Positives = 131/279 (46%), Gaps = 25/279 (8%)
Query: 153 WGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLG 210
WG+ S G +GL G + + EP K D I + ++ G H V + G V+T G
Sbjct: 4 WGNA--SFGQLGL--GGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCG 59
Query: 211 CGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFA 270
C + GQLG SR + AL Q V G T L+ + +++A
Sbjct: 60 CNDLGQLGH----EKSRKKPEQVVALDA-------QNIVAVSCGEAHTLALNDK-GQVYA 107
Query: 271 FGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYAL 330
+GL++ GQLG+ G + + P +L D VA G +H+L L+ +++
Sbjct: 108 WGLDSDGQLGLVGSEE--CIRVPRNIKSL----SDIQIVQVACGYYHSLALSKASEVFCW 161
Query: 331 GRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGK 390
G+ +YG+LGLG + +L+ L + +AAG ++SF +T SG ++ WG G+
Sbjct: 162 GQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQ 221
Query: 391 LGTGESEDLNEPT-LAAVDSRAPLRVSAGGQHTVLLVEE 428
LG + D P L ++ S+ + + G HT L +E
Sbjct: 222 LGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKE 260
Score = 97.9 bits (233), Expect = 7e-20
Identities = 91/307 (29%), Positives = 138/307 (44%), Gaps = 32/307 (10%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTFG 102
G V TCG D+GQLG + K + V AL IV V G HT+AL+ G+++ +G
Sbjct: 53 GTVYTCGCNDLGQLGHEK---SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWG 109
Query: 103 CNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
+ +G LG S E P+ + G HS AL + +V+ WG ++ +
Sbjct: 110 LDSDGQLGLVGSEECIR-VPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWG--QNKY 166
Query: 161 GSMGLVVRGREGKPCKEP--VKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLG 218
G +GL G + K P +K +G P +++A+GG H VLT SG +F G + GQLG
Sbjct: 167 GQLGL---GTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLG 223
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
D + L+ + Q + G T L + +F FG YGQ
Sbjct: 224 -------LNDENDRYVPNLL--KSLRSQKIVYICCGEDHTAAL-TKEGGVFTFGAGGYGQ 273
Query: 279 LGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT-LAANGQIYALGRCEYGR 337
LG + +P + L + +A G+ HT + ++G+IY+ G G+
Sbjct: 274 LGHNSTSHE---INPRKVFELMG----SIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQ 326
Query: 338 LGLGDKS 344
LG G S
Sbjct: 327 LGTGSTS 333
Score = 84.2 bits (199), Expect = 1e-15
Identities = 73/255 (28%), Positives = 115/255 (45%), Gaps = 21/255 (8%)
Query: 43 RGRVLTCGQGDVGQLGL--GEDVVETTKFKYVTALGD-KIVDVQAGGMHTIALDSSGKIW 99
+G+V G GQLGL E+ + + + +L D +IV V G H++AL + +++
Sbjct: 102 KGQVYAWGLDSDGQLGLVGSEECIRVPR--NIKSLSDIQIVQVACGYYHSLALSKASEVF 159
Query: 100 TFGCNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
+G N G LG T +K + +P+ + G +HS L +G ++ WG R
Sbjct: 160 CWGQNKYGQLGLGTDCKK-QTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWG--R 216
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQL 217
+ G +GL + +K + V I G DH LT GGVFT G G GQL
Sbjct: 217 NKFGQLGL--NDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274
Query: 218 GRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYG 277
G + S + R+ F + + A R H + FV + R+++FGL G
Sbjct: 275 GHNST-SHEINPRKVFELM---GSIVTEIACGRQ---HTSAFVPSS--GRIYSFGLGGNG 325
Query: 278 QLGITGEKRKTALFS 292
QLG + + F+
Sbjct: 326 QLGTGSTSNRKSPFT 340
Score = 77.8 bits (183), Expect = 8e-14
Identities = 58/182 (31%), Positives = 83/182 (45%), Gaps = 6/182 (3%)
Query: 39 APKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYV-TALGDKIVDVQAGGMHTIALDSSGK 97
A K V GQ GQLGLG D + T + + + LG + V AGG H+ L SG
Sbjct: 151 ALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGA 210
Query: 98 IWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
I+ +G N G LG N++ + G+ H+AAL + G V+ +G+
Sbjct: 211 IFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGA-- 268
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHL-VVLTTSGGVFTLGCGEQGQ 216
+G +G E P K V +G EIA G H + +SG +++ G G GQ
Sbjct: 269 GGYGQLGHNSTSHEINPRK--VFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQ 326
Query: 217 LG 218
LG
Sbjct: 327 LG 328
Score = 52.0 bits (119), Expect = 5e-06
Identities = 32/84 (38%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIA-LDSSGKIWT 100
K G V T G G GQLG E K +G + ++ G HT A + SSG+I++
Sbjct: 259 KEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYS 318
Query: 101 FGCNDEGALGR-ATSNEKDEGTPK 123
FG G LG +TSN K T K
Sbjct: 319 FGLGGNGQLGTGSTSNRKSPFTVK 342
>AY221963-1|AAO65480.1| 1057|Homo sapiens HECT and RCC1 containing
protein 4 isoform 1 protein.
Length = 1057
Score = 133 bits (321), Expect = 2e-30
Identities = 112/362 (30%), Positives = 164/362 (45%), Gaps = 29/362 (8%)
Query: 46 VLTCGQGDVGQLGLG----EDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+L G GQLGLG E V+E K + + ++ DV G HT+ + G ++T
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF--INKRVRDVGCGLRHTVFVLDDGTVYTC 58
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
GCND G LG S +K E G++H+ AL G VYAWG DS G
Sbjct: 59 GCNDLGQLGHEKSRKKPEQV--VALDAQNIVAVSCGEAHTLALNDKGQVYAWG--LDSDG 114
Query: 162 SMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLA 221
+GL V E +K V++A G H + L+ + VF G + GQLG L
Sbjct: 115 QLGL-VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG-LG 172
Query: 222 QRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGI 281
+ + Q +LL + Q AA G H +FVL A +F +G N +GQLG+
Sbjct: 173 TDCKKQTSPQLLKSLL---GIPFMQVAA---GGAH-SFVLTLSGA-IFGWGRNKFGQLGL 224
Query: 282 TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLG 341
E + + P +LR+ + G+ HT L G ++ G YG+LG
Sbjct: 225 NDENDR---YVPNLLKSLRS----QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 342 DKSGDAETLELIPKLQNKKCISIAAGTSNSFA-VTDSGEVYSWGMGSEGKLGTGESEDLN 400
S + ++ +L IA G ++ A V SG +YS+G+G G+LGTG + +
Sbjct: 278 STSHEINPRKVF-ELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336
Query: 401 EP 402
P
Sbjct: 337 SP 338
Score = 98.3 bits (234), Expect = 6e-20
Identities = 81/279 (29%), Positives = 131/279 (46%), Gaps = 25/279 (8%)
Query: 153 WGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLG 210
WG+ S G +GL G + + EP K D I + ++ G H V + G V+T G
Sbjct: 4 WGNA--SFGQLGL--GGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCG 59
Query: 211 CGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFA 270
C + GQLG SR + AL Q V G T L+ + +++A
Sbjct: 60 CNDLGQLGH----EKSRKKPEQVVALDA-------QNIVAVSCGEAHTLALNDK-GQVYA 107
Query: 271 FGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYAL 330
+GL++ GQLG+ G + + P +L D VA G +H+L L+ +++
Sbjct: 108 WGLDSDGQLGLVGSEE--CIRVPRNIKSL----SDIQIVQVACGYYHSLALSKASEVFCW 161
Query: 331 GRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGK 390
G+ +YG+LGLG + +L+ L + +AAG ++SF +T SG ++ WG G+
Sbjct: 162 GQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQ 221
Query: 391 LGTGESEDLNEPT-LAAVDSRAPLRVSAGGQHTVLLVEE 428
LG + D P L ++ S+ + + G HT L +E
Sbjct: 222 LGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKE 260
Score = 97.9 bits (233), Expect = 7e-20
Identities = 91/307 (29%), Positives = 138/307 (44%), Gaps = 32/307 (10%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTFG 102
G V TCG D+GQLG + K + V AL IV V G HT+AL+ G+++ +G
Sbjct: 53 GTVYTCGCNDLGQLGHEK---SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWG 109
Query: 103 CNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
+ +G LG S E P+ + G HS AL + +V+ WG ++ +
Sbjct: 110 LDSDGQLGLVGSEECIR-VPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWG--QNKY 166
Query: 161 GSMGLVVRGREGKPCKEP--VKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLG 218
G +GL G + K P +K +G P +++A+GG H VLT SG +F G + GQLG
Sbjct: 167 GQLGL---GTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLG 223
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
D + L+ + Q + G T L + +F FG YGQ
Sbjct: 224 -------LNDENDRYVPNLL--KSLRSQKIVYICCGEDHTAAL-TKEGGVFTFGAGGYGQ 273
Query: 279 LGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT-LAANGQIYALGRCEYGR 337
LG + +P + L + +A G+ HT + ++G+IY+ G G+
Sbjct: 274 LGHNSTSHE---INPRKVFELMG----SIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQ 326
Query: 338 LGLGDKS 344
LG G S
Sbjct: 327 LGTGSTS 333
Score = 84.2 bits (199), Expect = 1e-15
Identities = 73/255 (28%), Positives = 115/255 (45%), Gaps = 21/255 (8%)
Query: 43 RGRVLTCGQGDVGQLGL--GEDVVETTKFKYVTALGD-KIVDVQAGGMHTIALDSSGKIW 99
+G+V G GQLGL E+ + + + +L D +IV V G H++AL + +++
Sbjct: 102 KGQVYAWGLDSDGQLGLVGSEECIRVPR--NIKSLSDIQIVQVACGYYHSLALSKASEVF 159
Query: 100 TFGCNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
+G N G LG T +K + +P+ + G +HS L +G ++ WG R
Sbjct: 160 CWGQNKYGQLGLGTDCKK-QTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWG--R 216
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQL 217
+ G +GL + +K + V I G DH LT GGVFT G G GQL
Sbjct: 217 NKFGQLGL--NDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274
Query: 218 GRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYG 277
G + S + R+ F + + A R H + FV + R+++FGL G
Sbjct: 275 GHNST-SHEINPRKVFELM---GSIVTEIACGRQ---HTSAFVPSS--GRIYSFGLGGNG 325
Query: 278 QLGITGEKRKTALFS 292
QLG + + F+
Sbjct: 326 QLGTGSTSNRKSPFT 340
Score = 77.8 bits (183), Expect = 8e-14
Identities = 58/182 (31%), Positives = 83/182 (45%), Gaps = 6/182 (3%)
Query: 39 APKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYV-TALGDKIVDVQAGGMHTIALDSSGK 97
A K V GQ GQLGLG D + T + + + LG + V AGG H+ L SG
Sbjct: 151 ALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGA 210
Query: 98 IWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
I+ +G N G LG N++ + G+ H+AAL + G V+ +G+
Sbjct: 211 IFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGA-- 268
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHL-VVLTTSGGVFTLGCGEQGQ 216
+G +G E P K V +G EIA G H + +SG +++ G G GQ
Sbjct: 269 GGYGQLGHNSTSHEINPRK--VFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQ 326
Query: 217 LG 218
LG
Sbjct: 327 LG 328
Score = 52.0 bits (119), Expect = 5e-06
Identities = 32/84 (38%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIA-LDSSGKIWT 100
K G V T G G GQLG E K +G + ++ G HT A + SSG+I++
Sbjct: 259 KEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYS 318
Query: 101 FGCNDEGALGR-ATSNEKDEGTPK 123
FG G LG +TSN K T K
Sbjct: 319 FGLGGNGQLGTGSTSNRKSPFTVK 342
>AL356741-3|CAH74148.1| 1049|Homo sapiens hect domain and RLD 4
protein.
Length = 1049
Score = 133 bits (321), Expect = 2e-30
Identities = 112/362 (30%), Positives = 164/362 (45%), Gaps = 29/362 (8%)
Query: 46 VLTCGQGDVGQLGLG----EDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+L G GQLGLG E V+E K + + ++ DV G HT+ + G ++T
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF--INKRVRDVGCGLRHTVFVLDDGTVYTC 58
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
GCND G LG S +K E G++H+ AL G VYAWG DS G
Sbjct: 59 GCNDLGQLGHEKSRKKPEQV--VALDAQNIVAVSCGEAHTLALNDKGQVYAWG--LDSDG 114
Query: 162 SMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLA 221
+GL V E +K V++A G H + L+ + VF G + GQLG L
Sbjct: 115 QLGL-VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG-LG 172
Query: 222 QRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGI 281
+ + Q +LL + Q AA G H +FVL A +F +G N +GQLG+
Sbjct: 173 TDCKKQTSPQLLKSLL---GIPFMQVAA---GGAH-SFVLTLSGA-IFGWGRNKFGQLGL 224
Query: 282 TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLG 341
E + + P +LR+ + G+ HT L G ++ G YG+LG
Sbjct: 225 NDENDR---YVPNLLKSLRS----QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 342 DKSGDAETLELIPKLQNKKCISIAAGTSNSFA-VTDSGEVYSWGMGSEGKLGTGESEDLN 400
S + ++ +L IA G ++ A V SG +YS+G+G G+LGTG + +
Sbjct: 278 STSHEINPRKVF-ELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336
Query: 401 EP 402
P
Sbjct: 337 SP 338
Score = 98.3 bits (234), Expect = 6e-20
Identities = 81/279 (29%), Positives = 131/279 (46%), Gaps = 25/279 (8%)
Query: 153 WGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLG 210
WG+ S G +GL G + + EP K D I + ++ G H V + G V+T G
Sbjct: 4 WGNA--SFGQLGL--GGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCG 59
Query: 211 CGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFA 270
C + GQLG SR + AL Q V G T L+ + +++A
Sbjct: 60 CNDLGQLGH----EKSRKKPEQVVALDA-------QNIVAVSCGEAHTLALNDK-GQVYA 107
Query: 271 FGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYAL 330
+GL++ GQLG+ G + + P +L D VA G +H+L L+ +++
Sbjct: 108 WGLDSDGQLGLVGSEE--CIRVPRNIKSL----SDIQIVQVACGYYHSLALSKASEVFCW 161
Query: 331 GRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGK 390
G+ +YG+LGLG + +L+ L + +AAG ++SF +T SG ++ WG G+
Sbjct: 162 GQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQ 221
Query: 391 LGTGESEDLNEPT-LAAVDSRAPLRVSAGGQHTVLLVEE 428
LG + D P L ++ S+ + + G HT L +E
Sbjct: 222 LGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKE 260
Score = 97.9 bits (233), Expect = 7e-20
Identities = 91/307 (29%), Positives = 138/307 (44%), Gaps = 32/307 (10%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTFG 102
G V TCG D+GQLG + K + V AL IV V G HT+AL+ G+++ +G
Sbjct: 53 GTVYTCGCNDLGQLGHEK---SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWG 109
Query: 103 CNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
+ +G LG S E P+ + G HS AL + +V+ WG ++ +
Sbjct: 110 LDSDGQLGLVGSEECIR-VPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWG--QNKY 166
Query: 161 GSMGLVVRGREGKPCKEP--VKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLG 218
G +GL G + K P +K +G P +++A+GG H VLT SG +F G + GQLG
Sbjct: 167 GQLGL---GTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLG 223
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
D + L+ + Q + G T L + +F FG YGQ
Sbjct: 224 -------LNDENDRYVPNLL--KSLRSQKIVYICCGEDHTAAL-TKEGGVFTFGAGGYGQ 273
Query: 279 LGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT-LAANGQIYALGRCEYGR 337
LG + +P + L + +A G+ HT + ++G+IY+ G G+
Sbjct: 274 LGHNSTSHE---INPRKVFELMG----SIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQ 326
Query: 338 LGLGDKS 344
LG G S
Sbjct: 327 LGTGSTS 333
Score = 84.2 bits (199), Expect = 1e-15
Identities = 73/255 (28%), Positives = 115/255 (45%), Gaps = 21/255 (8%)
Query: 43 RGRVLTCGQGDVGQLGL--GEDVVETTKFKYVTALGD-KIVDVQAGGMHTIALDSSGKIW 99
+G+V G GQLGL E+ + + + +L D +IV V G H++AL + +++
Sbjct: 102 KGQVYAWGLDSDGQLGLVGSEECIRVPR--NIKSLSDIQIVQVACGYYHSLALSKASEVF 159
Query: 100 TFGCNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
+G N G LG T +K + +P+ + G +HS L +G ++ WG R
Sbjct: 160 CWGQNKYGQLGLGTDCKK-QTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWG--R 216
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQL 217
+ G +GL + +K + V I G DH LT GGVFT G G GQL
Sbjct: 217 NKFGQLGL--NDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274
Query: 218 GRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYG 277
G + S + R+ F + + A R H + FV + R+++FGL G
Sbjct: 275 GHNST-SHEINPRKVFELM---GSIVTEIACGRQ---HTSAFVPSS--GRIYSFGLGGNG 325
Query: 278 QLGITGEKRKTALFS 292
QLG + + F+
Sbjct: 326 QLGTGSTSNRKSPFT 340
Score = 77.8 bits (183), Expect = 8e-14
Identities = 58/182 (31%), Positives = 83/182 (45%), Gaps = 6/182 (3%)
Query: 39 APKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYV-TALGDKIVDVQAGGMHTIALDSSGK 97
A K V GQ GQLGLG D + T + + + LG + V AGG H+ L SG
Sbjct: 151 ALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGA 210
Query: 98 IWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
I+ +G N G LG N++ + G+ H+AAL + G V+ +G+
Sbjct: 211 IFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGA-- 268
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHL-VVLTTSGGVFTLGCGEQGQ 216
+G +G E P K V +G EIA G H + +SG +++ G G GQ
Sbjct: 269 GGYGQLGHNSTSHEINPRK--VFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQ 326
Query: 217 LG 218
LG
Sbjct: 327 LG 328
Score = 52.0 bits (119), Expect = 5e-06
Identities = 32/84 (38%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIA-LDSSGKIWT 100
K G V T G G GQLG E K +G + ++ G HT A + SSG+I++
Sbjct: 259 KEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYS 318
Query: 101 FGCNDEGALGR-ATSNEKDEGTPK 123
FG G LG +TSN K T K
Sbjct: 319 FGLGGNGQLGTGSTSNRKSPFTVK 342
>AL133551-3|CAI16032.1| 1049|Homo sapiens hect domain and RLD 4
protein.
Length = 1049
Score = 133 bits (321), Expect = 2e-30
Identities = 112/362 (30%), Positives = 164/362 (45%), Gaps = 29/362 (8%)
Query: 46 VLTCGQGDVGQLGLG----EDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+L G GQLGLG E V+E K + + ++ DV G HT+ + G ++T
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF--INKRVRDVGCGLRHTVFVLDDGTVYTC 58
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
GCND G LG S +K E G++H+ AL G VYAWG DS G
Sbjct: 59 GCNDLGQLGHEKSRKKPEQV--VALDAQNIVAVSCGEAHTLALNDKGQVYAWG--LDSDG 114
Query: 162 SMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLA 221
+GL V E +K V++A G H + L+ + VF G + GQLG L
Sbjct: 115 QLGL-VGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG-LG 172
Query: 222 QRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGI 281
+ + Q +LL + Q AA G H +FVL A +F +G N +GQLG+
Sbjct: 173 TDCKKQTSPQLLKSLL---GIPFMQVAA---GGAH-SFVLTLSGA-IFGWGRNKFGQLGL 224
Query: 282 TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLG 341
E + + P +LR+ + G+ HT L G ++ G YG+LG
Sbjct: 225 NDENDR---YVPNLLKSLRS----QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 342 DKSGDAETLELIPKLQNKKCISIAAGTSNSFA-VTDSGEVYSWGMGSEGKLGTGESEDLN 400
S + ++ +L IA G ++ A V SG +YS+G+G G+LGTG + +
Sbjct: 278 STSHEINPRKVF-ELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRK 336
Query: 401 EP 402
P
Sbjct: 337 SP 338
Score = 98.3 bits (234), Expect = 6e-20
Identities = 81/279 (29%), Positives = 131/279 (46%), Gaps = 25/279 (8%)
Query: 153 WGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLG 210
WG+ S G +GL G + + EP K D I + ++ G H V + G V+T G
Sbjct: 4 WGNA--SFGQLGL--GGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCG 59
Query: 211 CGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFA 270
C + GQLG SR + AL Q V G T L+ + +++A
Sbjct: 60 CNDLGQLGH----EKSRKKPEQVVALDA-------QNIVAVSCGEAHTLALNDK-GQVYA 107
Query: 271 FGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYAL 330
+GL++ GQLG+ G + + P +L D VA G +H+L L+ +++
Sbjct: 108 WGLDSDGQLGLVGSEE--CIRVPRNIKSL----SDIQIVQVACGYYHSLALSKASEVFCW 161
Query: 331 GRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGK 390
G+ +YG+LGLG + +L+ L + +AAG ++SF +T SG ++ WG G+
Sbjct: 162 GQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQ 221
Query: 391 LGTGESEDLNEPT-LAAVDSRAPLRVSAGGQHTVLLVEE 428
LG + D P L ++ S+ + + G HT L +E
Sbjct: 222 LGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKE 260
Score = 97.9 bits (233), Expect = 7e-20
Identities = 91/307 (29%), Positives = 138/307 (44%), Gaps = 32/307 (10%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTFG 102
G V TCG D+GQLG + K + V AL IV V G HT+AL+ G+++ +G
Sbjct: 53 GTVYTCGCNDLGQLGHEK---SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWG 109
Query: 103 CNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
+ +G LG S E P+ + G HS AL + +V+ WG ++ +
Sbjct: 110 LDSDGQLGLVGSEECIR-VPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWG--QNKY 166
Query: 161 GSMGLVVRGREGKPCKEP--VKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLG 218
G +GL G + K P +K +G P +++A+GG H VLT SG +F G + GQLG
Sbjct: 167 GQLGL---GTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLG 223
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
D + L+ + Q + G T L + +F FG YGQ
Sbjct: 224 -------LNDENDRYVPNLL--KSLRSQKIVYICCGEDHTAAL-TKEGGVFTFGAGGYGQ 273
Query: 279 LGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT-LAANGQIYALGRCEYGR 337
LG + +P + L + +A G+ HT + ++G+IY+ G G+
Sbjct: 274 LGHNSTSHE---INPRKVFELMG----SIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQ 326
Query: 338 LGLGDKS 344
LG G S
Sbjct: 327 LGTGSTS 333
Score = 84.2 bits (199), Expect = 1e-15
Identities = 73/255 (28%), Positives = 115/255 (45%), Gaps = 21/255 (8%)
Query: 43 RGRVLTCGQGDVGQLGL--GEDVVETTKFKYVTALGD-KIVDVQAGGMHTIALDSSGKIW 99
+G+V G GQLGL E+ + + + +L D +IV V G H++AL + +++
Sbjct: 102 KGQVYAWGLDSDGQLGLVGSEECIRVPR--NIKSLSDIQIVQVACGYYHSLALSKASEVF 159
Query: 100 TFGCNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
+G N G LG T +K + +P+ + G +HS L +G ++ WG R
Sbjct: 160 CWGQNKYGQLGLGTDCKK-QTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWG--R 216
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQL 217
+ G +GL + +K + V I G DH LT GGVFT G G GQL
Sbjct: 217 NKFGQLGL--NDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274
Query: 218 GRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYG 277
G + S + R+ F + + A R H + FV + R+++FGL G
Sbjct: 275 GHNST-SHEINPRKVFELM---GSIVTEIACGRQ---HTSAFVPSS--GRIYSFGLGGNG 325
Query: 278 QLGITGEKRKTALFS 292
QLG + + F+
Sbjct: 326 QLGTGSTSNRKSPFT 340
Score = 77.8 bits (183), Expect = 8e-14
Identities = 58/182 (31%), Positives = 83/182 (45%), Gaps = 6/182 (3%)
Query: 39 APKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYV-TALGDKIVDVQAGGMHTIALDSSGK 97
A K V GQ GQLGLG D + T + + + LG + V AGG H+ L SG
Sbjct: 151 ALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGA 210
Query: 98 IWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
I+ +G N G LG N++ + G+ H+AAL + G V+ +G+
Sbjct: 211 IFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGA-- 268
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHL-VVLTTSGGVFTLGCGEQGQ 216
+G +G E P K V +G EIA G H + +SG +++ G G GQ
Sbjct: 269 GGYGQLGHNSTSHEINPRK--VFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQ 326
Query: 217 LG 218
LG
Sbjct: 327 LG 328
Score = 52.0 bits (119), Expect = 5e-06
Identities = 32/84 (38%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIA-LDSSGKIWT 100
K G V T G G GQLG E K +G + ++ G HT A + SSG+I++
Sbjct: 259 KEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYS 318
Query: 101 FGCNDEGALGR-ATSNEKDEGTPK 123
FG G LG +TSN K T K
Sbjct: 319 FGLGGNGQLGTGSTSNRKSPFTVK 342
>U50078-1|AAD12586.1| 4861|Homo sapiens p532 protein.
Length = 4861
Score = 123 bits (296), Expect = 2e-27
Identities = 97/353 (27%), Positives = 161/353 (45%), Gaps = 29/353 (8%)
Query: 89 TIALDSSGKIWTFGCNDEGALGRATSNEKDEGT---PKQXXXXXXXXXXXXGDSHSAALL 145
T + ++G + G G LG+ S++ T Q D HS AL
Sbjct: 4039 TFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALT 4098
Query: 146 QNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGG 205
++G+V++WG +G +G R+ +P ++ GE V+++ G H V+T+ G
Sbjct: 4099 ESGEVFSWGD--GDYGKLGHGNSDRQRRP--RQIEALQGEEVVQMSCGFKHSAVVTSDGK 4154
Query: 206 VFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQA--AARVWAGHHATFVLDA 263
+FT G G+ G+LG L S + +P RVT + +V G + T + A
Sbjct: 4155 LFTFGNGDYGRLG-LGNTSNKK----------LPERVTALEGYQIGQVACGLNHTLAVSA 4203
Query: 264 QHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAA 323
+ ++AFG +YG+LG+ TA SP + D L +G VA G ++ L
Sbjct: 4204 DGSMVWAFGDGDYGKLGLGNS---TAKSSPQKIDVLCGIGI----KKVACGTQFSVALTK 4256
Query: 324 NGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSW 383
+G +Y G+ L G ++ + + IP L +A G ++ A+ +G+VY+W
Sbjct: 4257 DGHVYTFGQDRLIGLPEG-RARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAW 4315
Query: 384 GMGSEGKLGTGESEDLNEPTL-AAVDSRAPLRVSAGGQHTVLLVEETSSQREP 435
G SEG+LG G + + EPTL + + ++SAG H+ R P
Sbjct: 4316 GSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAP 4368
Score = 94.3 bits (224), Expect = 9e-19
Identities = 89/349 (25%), Positives = 151/349 (43%), Gaps = 32/349 (9%)
Query: 82 VQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKD---EGTPKQXXXXXXXXXXXXGD 138
++AG T + + G + G G LG SN + + T + D
Sbjct: 408 IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSD 467
Query: 139 SHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKP--CKEPVKIDIGEPAVEIASGGDH 196
H+ A G+V++WG +G +G + P + P++ G+ V +++G H
Sbjct: 468 GHTLAFTTEGEVFSWGD--GDYGKLGHGNSSTQKYPKLIQGPLQ---GKVVVCVSAGYRH 522
Query: 197 LVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHH 256
+T G ++T G G+ G+LG S SR+ +P V V G
Sbjct: 523 SAAVTEDGELYTWGEGDFGRLGH--GDSNSRN---------IPTLVKDISNVGEVSCGSS 571
Query: 257 ATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQH 316
T L +++FG + G+LG R ++ P +AL+ + V G
Sbjct: 572 HTIALSKDGRTVWSFGGGDNGKLGHGDTNR---VYKPKVIEALQGM----FIRKVCAGSQ 624
Query: 317 HTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTD 376
+L L + GQ+YA G C LG G A +LI +L + + ++ G S+ A++
Sbjct: 625 SSLALTSTGQVYAWG-CG-ACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSH 682
Query: 377 SGEVYSWGMGSEGKLGTGESE-DLNEP-TLAAVDSRAPLRVSAGGQHTV 423
EVY+WG S G+ G G S + +P ++ +D A ++SAG H++
Sbjct: 683 DNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSL 731
Score = 91.9 bits (218), Expect = 5e-18
Identities = 57/181 (31%), Positives = 91/181 (50%), Gaps = 6/181 (3%)
Query: 248 AARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHA 307
A + AG + TFV+ + + A G +YG+LG+ G+ + + R++
Sbjct: 405 AQTIEAGQYCTFVISTDGS-VRACGKGSYGRLGL-GDSNNQSTLKKLTFEPHRSI---KK 459
Query: 308 WSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAG 367
S+ HTL G++++ G +YG+LG G+ S + LQ K + ++AG
Sbjct: 460 VSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAG 519
Query: 368 TSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTVLLVE 427
+S AVT+ GE+Y+WG G G+LG G+S N PTL S VS G HT+ L +
Sbjct: 520 YRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVG-EVSCGSSHTIALSK 578
Query: 428 E 428
+
Sbjct: 579 D 579
Score = 89.8 bits (213), Expect = 2e-17
Identities = 90/336 (26%), Positives = 148/336 (44%), Gaps = 26/336 (7%)
Query: 44 GRVLTCGQGDVGQLGLG--EDVVETTKFKYVTA-LGDKIVDVQAGGMHTIALDSSGKIWT 100
G VL CG+G G+LG G +D+ T + + ++V H++AL SG++++
Sbjct: 4046 GTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFS 4105
Query: 101 FGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
+G D G LG S+ + + G HSA + +G ++ +G+ +
Sbjct: 4106 WGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGN--GDY 4163
Query: 161 GSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGG-VFTLGCGEQGQLGR 219
G +GL K E V G ++A G +H + ++ G V+ G G+ G+LG
Sbjct: 4164 GRLGL--GNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLG- 4220
Query: 220 LAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQL 279
S ++ + Q L + +++ A G + L + ++ FG + +
Sbjct: 4221 -LGNSTAKSSPQKIDVL---CGIGIKKVA----CGTQFSVAL-TKDGHVYTFGQDRL--I 4269
Query: 280 GITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLG 339
G+ E R P + L V VA+G HTL LA+NG +YA G G+LG
Sbjct: 4270 GLP-EGRARNHNRPQQIPVLAGV----IIEDVAVGAEHTLALASNGDVYAWGSNSEGQLG 4324
Query: 340 LGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
LG + E L+ LQ K I+AG +S A T
Sbjct: 4325 LGHTNHVREP-TLVTGLQGKNVRQISAGRCHSAAWT 4359
Score = 88.2 bits (209), Expect = 6e-17
Identities = 89/337 (26%), Positives = 147/337 (43%), Gaps = 29/337 (8%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETT--KFKYVTALGDKIVDVQAGGM-HTIALDSSGKIWT 100
G V CG+G G+LGLG+ ++T K + K V G HT+A + G++++
Sbjct: 422 GSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFS 481
Query: 101 FGCNDEGALGRATSN-EKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDS 159
+G D G LG S+ +K + G HSAA+ ++G++Y WG
Sbjct: 482 WGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGE---- 537
Query: 160 HGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGG-VFTLGCGEQGQLG 218
G G + G + DI E++ G H + L+ G V++ G G+ G+LG
Sbjct: 538 -GDFGRLGHGDSNSRNIPTLVKDISNVG-EVSCGSSHTIALSKDGRTVWSFGGGDNGKLG 595
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
D + + ++ A + +V AG ++ L + +++A+G
Sbjct: 596 H-------GDTNRVYKPKVIEALQGM--FIRKVCAGSQSSLALTST-GQVYAWGCG--AC 643
Query: 279 LGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRL 338
LG G TAL P + L A V++G H L L+ + ++YA G G+
Sbjct: 644 LGC-GSSEATAL-RPKLIEELAAT----RIVDVSIGDSHCLALSHDNEVYAWGNNSMGQC 697
Query: 339 GLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
G G+ +G + + L I+AGTS+S A T
Sbjct: 698 GQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWT 734
Score = 78.2 bits (184), Expect = 6e-14
Identities = 82/331 (24%), Positives = 144/331 (43%), Gaps = 25/331 (7%)
Query: 97 KIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSF 156
+++ +G N L T + + PK G + + +G V A G
Sbjct: 373 EVYVWGSNSSHQLVEGTQEKILQ--PKLAPSFSDAQTIEAGQYCTFVISTDGSVRACG-- 428
Query: 157 RDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGD-HLVVLTTSGGVFTLGCGEQG 215
+ S+G +GL + K + V + G D H + TT G VF+ G G+ G
Sbjct: 429 KGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYG 488
Query: 216 QLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNN 275
+LG S+++ + L V A R H A D + L+ +G +
Sbjct: 489 KLGH--GNSSTQKYPKLIQGPLQGKVVVCVSAGYR----HSAAVTEDGE---LYTWGEGD 539
Query: 276 YGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQ-IYALGRCE 334
+G+LG G+ + PT + VG+ V+ G HT+ L+ +G+ +++ G +
Sbjct: 540 FGRLG-HGDSNSRNI--PTLVKDISNVGE------VSCGSSHTIALSKDGRTVWSFGGGD 590
Query: 335 YGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTG 394
G+LG GD + + ++I LQ + AG+ +S A+T +G+VY+WG G+ G+
Sbjct: 591 NGKLGHGDTNRVYKP-KVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSS 649
Query: 395 ESEDLNEPTLAAVDSRAPLRVSAGGQHTVLL 425
E+ L + + + + VS G H + L
Sbjct: 650 EATALRPKLIEELAATRIVDVSIGDSHCLAL 680
Score = 76.6 bits (180), Expect = 2e-13
Identities = 43/122 (35%), Positives = 66/122 (54%), Gaps = 5/122 (4%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQN---KKCISIAAG 367
V GQ+ T + ANG + A G YGRLG G+ S D L +I LQ + ++
Sbjct: 4032 VICGQNCTFVIQANGTVLACGEGSYGRLGQGN-SDDLHVLTVISALQGFVVTQLVTSCGS 4090
Query: 368 TSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEP-TLAAVDSRAPLRVSAGGQHTVLLV 426
+S A+T+SGEV+SWG G GKLG G S+ P + A+ +++S G +H+ ++
Sbjct: 4091 DGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVT 4150
Query: 427 EE 428
+
Sbjct: 4151 SD 4152
Score = 70.5 bits (165), Expect = 1e-11
Identities = 50/196 (25%), Positives = 96/196 (48%), Gaps = 7/196 (3%)
Query: 236 LLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTE 295
++VPA A +V G + TFV+ A + + A G +YG+L G+ L T
Sbjct: 4017 VMVPAAAPSFSQAQQVICGQNCTFVIQA-NGTVLACGEGSYGRL---GQGNSDDLHVLTV 4072
Query: 296 CDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPK 355
AL+ ++ H++ L +G++++ G +YG+LG G+ + I
Sbjct: 4073 ISALQGFVVTQLVTSCG-SDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQ-IEA 4130
Query: 356 LQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEP-TLAAVDSRAPLR 414
LQ ++ + ++ G +S VT G+++++G G G+LG G + + P + A++ +
Sbjct: 4131 LQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQ 4190
Query: 415 VSAGGQHTVLLVEETS 430
V+ G HT+ + + S
Sbjct: 4191 VACGLNHTLAVSADGS 4206
Score = 32.3 bits (70), Expect = 4.1
Identities = 20/66 (30%), Positives = 32/66 (48%), Gaps = 2/66 (3%)
Query: 368 TSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTVLLVE 427
T ++ V+++ EVY WG S +L G E + +P LA S A + GQ+ ++
Sbjct: 362 TGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDA--QTIEAGQYCTFVIS 419
Query: 428 ETSSQR 433
S R
Sbjct: 420 TDGSVR 425
>AF071172-1|AAD08657.1| 4834|Homo sapiens HERC2 protein.
Length = 4834
Score = 122 bits (293), Expect = 4e-27
Identities = 112/405 (27%), Positives = 171/405 (42%), Gaps = 33/405 (8%)
Query: 44 GRVLTCGQGDVGQLG--LGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
G + G GQLG G V T + + L + V + G A+ + GK++
Sbjct: 3952 GTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATL--RPVQLIGGEQTLFAVTADGKLYAT 4009
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXX--XGDSHSAALLQNGDVYAWGSFRDS 159
G G LG + T + G H AL G+VY+WG D
Sbjct: 4010 GYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAED- 4068
Query: 160 HGSMGLVVRGREGKPCKEPVKIDI--GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQL 217
G +G G PC P I+ G V++A+GG H +T +G ++T G G G+L
Sbjct: 4069 -GKLG---HGNRS-PCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRL 4123
Query: 218 GRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYG 277
G D+ LV A R +G T L ++++G +YG
Sbjct: 4124 GH-------SDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDT-VWSWGDGDYG 4175
Query: 278 QLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGR 337
+LG G P + D+L +G V G ++ L +G +Y G+ +Y R
Sbjct: 4176 KLGRGGSDGCKV---PMKIDSLTGLGV----VKVECGSQFSVALTKSGAVYTWGKGDYHR 4228
Query: 338 LGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESE 397
LG G + + LQ KK I+IA G+ + T+ GEVY+WG EG+LG G +
Sbjct: 4229 LGHGSDDHVRRPRQ-VQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTN 4287
Query: 398 DLNEPTL-AAVDSRAPLRVSAGGQHTVL--LVEETSSQREPSPIP 439
+ P L AA+ + RV+ G HT+ + S+ + P+ +P
Sbjct: 4288 AIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVP 4332
Score = 109 bits (262), Expect = 2e-23
Identities = 107/396 (27%), Positives = 165/396 (41%), Gaps = 32/396 (8%)
Query: 36 IPTAPKKRGRVLTCGQGDVGQLG-LGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDS 94
+ +A R +V G D QLG L ++ F T +V V G A+
Sbjct: 2951 LESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSE-TLSALNVVQVAGGSKSLFAVTV 3009
Query: 95 SGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXX----XXXXGDSHSAALLQNGDV 150
GK++ G G LG S+ P+Q G H+ AL +G V
Sbjct: 3010 EGKVYACGEATNGRLGLGISSGTVP-IPRQITALSSYVVKKVAVHSGGRHATALTVDGKV 3068
Query: 151 YAWGSFRDSHGSMGLVVRGREGKP-CKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTL 209
++WG D G +G R KP E +K + +IA G H LT+SG ++T
Sbjct: 3069 FSWGEGDD--GKLGHFSRMNCDKPRLIEALKT---KRIRDIACGSSHSAALTSSGELYTW 3123
Query: 210 GCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLD-AQHARL 268
G GE G+LG D +V +V L +V G L +
Sbjct: 3124 GLGEYGRLGH-------GDNTTQLKPKMV--KVLLGHRVIQVACGSRDAQTLALTDEGLV 3174
Query: 269 FAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIY 328
F++G ++G+LG G + P + L G + G +L L +G ++
Sbjct: 3175 FSWGDGDFGKLGRGGSEGCNI---PQNIERLNGQGV----CQIECGAQFSLALTKSGVVW 3227
Query: 329 ALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSE 388
G+ +Y RLG G +++ L+ KK + +A G + AVTDSG+VY+WG
Sbjct: 3228 TWGKGDYFRLGHGSDV-HVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDH 3286
Query: 389 GKLGTGESEDLNEPTLA-AVDSRAPLRVSAGGQHTV 423
G+ G G + +PTL ++ + RV+ G H+V
Sbjct: 3287 GQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSV 3322
Score = 99.5 bits (237), Expect = 2e-20
Identities = 67/239 (28%), Positives = 112/239 (46%), Gaps = 13/239 (5%)
Query: 192 SGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARV 251
S G H + L +G V++ GCG+ G+LG + + + SA + + +
Sbjct: 502 SDGHHYLALAATGEVYSWGCGDGGRLGH--GDTVPLEEPKVISAF---SGKQAGKHVVHI 556
Query: 252 WAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAV 311
G + + A+ L+ +G NYG+LG + + L+ + A
Sbjct: 557 ACGSTYSAAITAE-GELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVID-----VAC 610
Query: 312 ALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNS 371
G TL + NGQ+++ G +YG+LG G G +T +LI KLQ+ + + G+ S
Sbjct: 611 GSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG-CKTPKLIEKLQDLDVVKVRCGSQFS 669
Query: 372 FAVTDSGEVYSWGMGSEGKLGTGESEDLNEP-TLAAVDSRAPLRVSAGGQHTVLLVEET 429
A+T G+VYSWG G +LG G E + P L + + + V+AG H + L E++
Sbjct: 670 IALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDS 728
Score = 82.2 bits (194), Expect = 4e-15
Identities = 68/249 (27%), Positives = 111/249 (44%), Gaps = 16/249 (6%)
Query: 140 HSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVV 199
H AL G+VY+WG G V E K G+ V IA G +
Sbjct: 506 HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAA 565
Query: 200 LTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATF 259
+T G ++T G G G+LG +S D +LV L+ +G T
Sbjct: 566 ITAEGELYTWGRGNYGRLGH----GSSEDEA---IPMLVAGLKGLKVIDVACGSGDAQTL 618
Query: 260 VLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTL 319
+ ++ +++++G +YG+LG G +P + L+ D V G ++
Sbjct: 619 AV-TENGQVWSWGDGDYGKLGRGGSD---GCKTPKLIEKLQ----DLDVVKVRCGSQFSI 670
Query: 320 TLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGE 379
L +GQ+Y+ G+ + RLG G + +L+ LQ KK I +AAG+++ A+T+ E
Sbjct: 671 ALTKDGQVYSWGKGDNQRLGHGTEE-HVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSE 729
Query: 380 VYSWGMGSE 388
V+SWG +
Sbjct: 730 VHSWGSNDQ 738
Score = 68.9 bits (161), Expect = 4e-11
Identities = 51/177 (28%), Positives = 80/177 (45%), Gaps = 10/177 (5%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGG--MHTIALDSSGKIWTF 101
G + T G+G+ G+LG G E G K++DV G T+A+ +G++W++
Sbjct: 570 GELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSW 629
Query: 102 GCNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDS 159
G D G LGR S+ TPK + G S AL ++G VY+WG +
Sbjct: 630 GDGDYGKLGRGGSDGCK--TPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQ 687
Query: 160 HGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQ 216
G R K E ++ G+ +++A+G H + LT V + G +Q Q
Sbjct: 688 RLGHGTEEHVRYPK-LLEGLQ---GKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740
Score = 60.1 bits (139), Expect = 2e-08
Identities = 38/103 (36%), Positives = 50/103 (48%), Gaps = 2/103 (1%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWT 100
K G V T G+GD +LG G DV K + V L G KIV V G +H +A+ SG+++
Sbjct: 3222 KSGVVWTWGKGDYFRLGHGSDV-HVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYA 3280
Query: 101 FGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAA 143
+G ND G G T+ + T Q G SHS A
Sbjct: 3281 WGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVA 3323
Score = 55.6 bits (128), Expect = 4e-07
Identities = 39/146 (26%), Positives = 67/146 (45%), Gaps = 10/146 (6%)
Query: 80 VDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXX------ 133
+ + G H +AL ++G+++++GC D G LG + +E PK
Sbjct: 498 IAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEE--PKVISAFSGKQAGKHVVH 555
Query: 134 XXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASG 193
G ++SAA+ G++Y WG R ++G +G E P + V SG
Sbjct: 556 IACGSTYSAAITAEGELYTWG--RGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSG 613
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGR 219
+ +T +G V++ G G+ G+LGR
Sbjct: 614 DAQTLAVTENGQVWSWGDGDYGKLGR 639
Score = 55.6 bits (128), Expect = 4e-07
Identities = 34/114 (29%), Positives = 56/114 (49%), Gaps = 4/114 (3%)
Query: 318 TLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDS 377
TL+ +G IY G G+LG G + + L + + + G FAVT
Sbjct: 3945 TLSAGGSGTIYGWGHNHRGQLG-GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTAD 4003
Query: 378 GEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLR---VSAGGQHTVLLVEE 428
G++Y+ G G+ G+LG G +E ++ PTL ++ V++GG+H + L E
Sbjct: 4004 GKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSE 4057
Score = 55.2 bits (127), Expect = 5e-07
Identities = 35/119 (29%), Positives = 56/119 (47%), Gaps = 4/119 (3%)
Query: 39 APKKRGRVLTCGQGDVGQLGL-GEDVVETTKFKYVTALGD-KIVDVQAGGMHTIALDSSG 96
A + G+V + G GD G+LG G D +T K + L D +V V+ G +IAL G
Sbjct: 619 AVTENGQVWSWGDGDYGKLGRGGSDGCKTPKL--IEKLQDLDVVKVRCGSQFSIALTKDG 676
Query: 97 KIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGS 155
+++++G D LG T + G +H AL ++ +V++WGS
Sbjct: 677 QVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGS 735
Score = 55.2 bits (127), Expect = 5e-07
Identities = 29/82 (35%), Positives = 44/82 (53%), Gaps = 2/82 (2%)
Query: 35 EIPTAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALD 93
+ A K G V T G+GD +LG G D + + V L G K++ + G +H +
Sbjct: 4207 QFSVALTKSGAVYTWGKGDYHRLGHGSD-DHVRRPRQVQGLQGKKVIAIATGSLHCVCCT 4265
Query: 94 SSGKIWTFGCNDEGALGRATSN 115
G+++T+G NDEG LG T+N
Sbjct: 4266 EDGEVYTWGDNDEGQLGDGTTN 4287
Score = 42.3 bits (95), Expect = 0.004
Identities = 24/67 (35%), Positives = 40/67 (59%), Gaps = 4/67 (5%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKF-KYVTAL-GDKIVDVQAGGMHTIALDSSGKIW 99
K G+V + G+GD +LG G + E ++ K + L G K++DV AG H +AL ++
Sbjct: 674 KDGQVYSWGKGDNQRLGHGTE--EHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVH 731
Query: 100 TFGCNDE 106
++G ND+
Sbjct: 732 SWGSNDQ 738
>D25215-1|BAA04945.2| 1054|Homo sapiens KIAA0032 protein.
Length = 1054
Score = 121 bits (291), Expect = 7e-27
Identities = 104/365 (28%), Positives = 171/365 (46%), Gaps = 30/365 (8%)
Query: 45 RVLTC-GQGDVGQLGLGEDVVETTKFKYVTA-LGDKIV-DVQAGGMHTIALDSSGKIWTF 101
R + C G +GQ G+ ++ V + D+ V +V GG H++ L G+++T
Sbjct: 3 RTMLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTC 62
Query: 102 GCNDEGALGRATSNEKDEGTPKQ--XXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDS 159
G N +G LG +E++ P+Q G+SHS AL G +++WG+ S
Sbjct: 63 GLNTKGQLG----HEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGA--GS 116
Query: 160 HGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGR 219
G +GL+ + K++ + ++++ G H + L G FT G GQLG
Sbjct: 117 DGQLGLMTTEDSVAVPRLIQKLN-QQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLG- 174
Query: 220 LAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQL 279
L + S+ + Q +L + L Q AA G H +F L A +F +G+NN GQL
Sbjct: 175 LGKEFPSQASPQRVRSL---EGIPLAQVAA---GGAH-SFALSLSGA-VFGWGMNNAGQL 226
Query: 280 GITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLG 339
G++ EK + SP LR ++ G+ HT L +G ++ G G+LG
Sbjct: 227 GLSDEKDRE---SPCHVKLLRT----QKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLG 279
Query: 340 LGDKSGDAETLELIPKLQNKKCISIAAGTSNSFA-VTDSGEVYSWGMGSEGKLGTGESED 398
D D + +L + IA G ++ A V SG +Y++G G+ G+LGTG + +
Sbjct: 280 -HDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCN 338
Query: 399 LNEPT 403
+ P+
Sbjct: 339 VKCPS 343
Score = 101 bits (242), Expect = 6e-21
Identities = 89/304 (29%), Positives = 135/304 (44%), Gaps = 32/304 (10%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWTFG 102
G V TCG GQLG E K + + AL D+ I+ V G H++AL G+++++G
Sbjct: 57 GEVYTCGLNTKGQLGHER---EGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWG 113
Query: 103 CNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
+G LG T+ E P+ Q G+ H AL +G + WG ++SH
Sbjct: 114 AGSDGQLGLMTT-EDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWG--KNSH 170
Query: 161 GSMGLVVRGREGKPCKEPVKIDI--GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLG 218
G +GL G+E P ++ G P ++A+GG H L+ SG VF G GQLG
Sbjct: 171 GQLGL---GKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLG 227
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
++ ++ Q + G T VL + +F FG + GQ
Sbjct: 228 LSDEKDRESPCH---------VKLLRTQKVVYISCGEEHTAVL-TKSGGVFTFGAGSCGQ 277
Query: 279 LGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT-LAANGQIYALGRCEYGR 337
LG + +P L +G + + +A G+ HTL + ++G IYA G G+
Sbjct: 278 LGHDSMNDEV---NPRR--VLELMGSE--VTQIACGRQHTLAFVPSSGLIYAFGCGARGQ 330
Query: 338 LGLG 341
LG G
Sbjct: 331 LGTG 334
Score = 100 bits (239), Expect = 1e-20
Identities = 70/240 (29%), Positives = 118/240 (49%), Gaps = 19/240 (7%)
Query: 189 EIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAA 248
E+A GG+H V L G V+T G +GQLG +R ++ + G A Q
Sbjct: 42 EVACGGNHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGALA---------DQHI 90
Query: 249 ARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAW 308
V G + L + +LF++G + GQLG+ + A+ P L +
Sbjct: 91 IHVACGESHSLAL-SDRGQLFSWGAGSDGQLGLMTTEDSVAV--PRLIQKL----NQQTI 143
Query: 309 SAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGT 368
V+ G H L LAA+GQ + G+ +G+LGLG + + + + L+ +AAG
Sbjct: 144 LQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG 203
Query: 369 SNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT-LAAVDSRAPLRVSAGGQHTVLLVE 427
++SFA++ SG V+ WGM + G+LG + +D P + + ++ + +S G +HT +L +
Sbjct: 204 AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTK 263
Score = 99.5 bits (237), Expect = 2e-20
Identities = 82/292 (28%), Positives = 140/292 (47%), Gaps = 25/292 (8%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREG-KPCKEPVKIDIGEPAVEIASGGD 195
G +HS LL++G+VY G ++ G +G REG KP E + + + +A G
Sbjct: 46 GGNHSVFLLEDGEVYTCGL--NTKGQLG---HEREGNKP--EQIGALADQHIIHVACGES 98
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H + L+ G +F+ G G GQLG + + R + + T+ Q + W H
Sbjct: 99 HSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPR----LIQKLNQQTILQVSCGNW--H 152
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
D Q F +G N++GQLG+ E A SP +L + + VA G
Sbjct: 153 CLALAADGQ---FFTWGKNSHGQLGLGKEFPSQA--SPQRVRSLEGI----PLAQVAAGG 203
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
H+ L+ +G ++ G G+LGL D+ D E+ + L+ +K + I+ G ++ +T
Sbjct: 204 AHSFALSLSGAVFGWGMNNAGQLGLSDEK-DRESPCHVKLLRTQKVVYISCGEEHTAVLT 262
Query: 376 DSGEVYSWGMGSEGKLG-TGESEDLNEPTLAAVDSRAPLRVSAGGQHTVLLV 426
SG V+++G GS G+LG ++++N + + +++ G QHT+ V
Sbjct: 263 KSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFV 314
Score = 91.1 bits (216), Expect = 8e-18
Identities = 76/256 (29%), Positives = 110/256 (42%), Gaps = 18/256 (7%)
Query: 43 RGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWTF 101
RG++ + G G GQLGL + + L + I+ V G H +AL + G+ +T+
Sbjct: 106 RGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTW 165
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXX--XXXXXGDSHSAALLQNGDVYAWGSFRDS 159
G N G LG + +P++ G +HS AL +G V+ WG ++
Sbjct: 166 GKNSHGQLGLG-KEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGM--NN 222
Query: 160 HGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGR 219
G +GL PC VK+ + V I+ G +H VLT SGGVFT G G GQLG
Sbjct: 223 AGQLGLSDEKDRESPCH--VKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGH 280
Query: 220 LAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQL 279
+ R L+ + VT ++ G T ++AFG GQL
Sbjct: 281 DSMNDEVNPRR---VLELMGSEVT------QIACGRQHTLAFVPSSGLIYAFGCGARGQL 331
Query: 280 GITGEKRKTALFSPTE 295
G TG SP +
Sbjct: 332 G-TGHTCNVKCPSPVK 346
Score = 49.6 bits (113), Expect = 3e-05
Identities = 29/78 (37%), Positives = 38/78 (48%), Gaps = 2/78 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIA-LDSSGKIWT 100
K G V T G G GQLG E + + +G ++ + G HT+A + SSG I+
Sbjct: 263 KSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYA 322
Query: 101 FGCNDEGALGRA-TSNEK 117
FGC G LG T N K
Sbjct: 323 FGCGARGQLGTGHTCNVK 340
>BC038960-1|AAH38960.1| 368|Homo sapiens HERC3 protein protein.
Length = 368
Score = 120 bits (289), Expect = 1e-26
Identities = 103/363 (28%), Positives = 170/363 (46%), Gaps = 29/363 (7%)
Query: 46 VLTCGQGDVGQLGLGEDVVETTKFKYVTA-LGDKIV-DVQAGGMHTIALDSSGKIWTFGC 103
+L G +GQ G+ ++ V + D+ V +V GG H++ L G+++T G
Sbjct: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
Query: 104 NDEGALGRATSNEKDEGTPKQ--XXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
N +G LG +E++ P+Q G+SHS AL G +++WG+ S G
Sbjct: 61 NTKGQLG----HEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGA--GSDG 114
Query: 162 SMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLA 221
+GL+ + K++ + ++++ G H + L G FT G GQLG L
Sbjct: 115 QLGLMTTEDSVAVPRLIQKLN-QQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLG-LG 172
Query: 222 QRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGI 281
+ S+ + Q +L + L Q AA G H +F L A +F +G+NN GQLG+
Sbjct: 173 KEFPSQASPQRVRSL---EGIPLAQVAA---GGAH-SFALSLSGA-VFGWGMNNAGQLGL 224
Query: 282 TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLG 341
+ EK + SP LR ++ G+ HT L +G ++ G G+LG
Sbjct: 225 SDEKDRE---SPCHVKLLRT----QKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLG-H 276
Query: 342 DKSGDAETLELIPKLQNKKCISIAAGTSNSFA-VTDSGEVYSWGMGSEGKLGTGESEDLN 400
D D + +L + IA G ++ A V SG +Y++G G+ G+LGTG + ++
Sbjct: 277 DSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVK 336
Query: 401 EPT 403
P+
Sbjct: 337 CPS 339
Score = 101 bits (242), Expect = 6e-21
Identities = 89/304 (29%), Positives = 135/304 (44%), Gaps = 32/304 (10%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWTFG 102
G V TCG GQLG E K + + AL D+ I+ V G H++AL G+++++G
Sbjct: 53 GEVYTCGLNTKGQLGHER---EGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWG 109
Query: 103 CNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
+G LG T+ E P+ Q G+ H AL +G + WG ++SH
Sbjct: 110 AGSDGQLGLMTT-EDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWG--KNSH 166
Query: 161 GSMGLVVRGREGKPCKEPVKIDI--GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLG 218
G +GL G+E P ++ G P ++A+GG H L+ SG VF G GQLG
Sbjct: 167 GQLGL---GKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLG 223
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
++ ++ Q + G T VL + +F FG + GQ
Sbjct: 224 LSDEKDRESPCH---------VKLLRTQKVVYISCGEEHTAVL-TKSGGVFTFGAGSCGQ 273
Query: 279 LGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT-LAANGQIYALGRCEYGR 337
LG + +P L +G + + +A G+ HTL + ++G IYA G G+
Sbjct: 274 LGHDSMNDEV---NPRR--VLELMGSE--VTQIACGRQHTLAFVPSSGLIYAFGCGARGQ 326
Query: 338 LGLG 341
LG G
Sbjct: 327 LGTG 330
Score = 100 bits (239), Expect = 1e-20
Identities = 70/240 (29%), Positives = 118/240 (49%), Gaps = 19/240 (7%)
Query: 189 EIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAA 248
E+A GG+H V L G V+T G +GQLG +R ++ + G A Q
Sbjct: 38 EVACGGNHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGALA---------DQHI 86
Query: 249 ARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAW 308
V G + L + +LF++G + GQLG+ + A+ P L +
Sbjct: 87 IHVACGESHSLAL-SDRGQLFSWGAGSDGQLGLMTTEDSVAV--PRLIQKL----NQQTI 139
Query: 309 SAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGT 368
V+ G H L LAA+GQ + G+ +G+LGLG + + + + L+ +AAG
Sbjct: 140 LQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG 199
Query: 369 SNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT-LAAVDSRAPLRVSAGGQHTVLLVE 427
++SFA++ SG V+ WGM + G+LG + +D P + + ++ + +S G +HT +L +
Sbjct: 200 AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTK 259
Score = 99.5 bits (237), Expect = 2e-20
Identities = 82/292 (28%), Positives = 140/292 (47%), Gaps = 25/292 (8%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREG-KPCKEPVKIDIGEPAVEIASGGD 195
G +HS LL++G+VY G ++ G +G REG KP E + + + +A G
Sbjct: 42 GGNHSVFLLEDGEVYTCGL--NTKGQLG---HEREGNKP--EQIGALADQHIIHVACGES 94
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H + L+ G +F+ G G GQLG + + R + + T+ Q + W H
Sbjct: 95 HSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPR----LIQKLNQQTILQVSCGNW--H 148
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
D Q F +G N++GQLG+ E A SP +L + + VA G
Sbjct: 149 CLALAADGQ---FFTWGKNSHGQLGLGKEFPSQA--SPQRVRSLEGI----PLAQVAAGG 199
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
H+ L+ +G ++ G G+LGL D+ D E+ + L+ +K + I+ G ++ +T
Sbjct: 200 AHSFALSLSGAVFGWGMNNAGQLGLSDEK-DRESPCHVKLLRTQKVVYISCGEEHTAVLT 258
Query: 376 DSGEVYSWGMGSEGKLG-TGESEDLNEPTLAAVDSRAPLRVSAGGQHTVLLV 426
SG V+++G GS G+LG ++++N + + +++ G QHT+ V
Sbjct: 259 KSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFV 310
Score = 91.1 bits (216), Expect = 8e-18
Identities = 76/256 (29%), Positives = 110/256 (42%), Gaps = 18/256 (7%)
Query: 43 RGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWTF 101
RG++ + G G GQLGL + + L + I+ V G H +AL + G+ +T+
Sbjct: 102 RGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTW 161
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXX--XXXXXGDSHSAALLQNGDVYAWGSFRDS 159
G N G LG + +P++ G +HS AL +G V+ WG ++
Sbjct: 162 GKNSHGQLGLG-KEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGM--NN 218
Query: 160 HGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGR 219
G +GL PC VK+ + V I+ G +H VLT SGGVFT G G GQLG
Sbjct: 219 AGQLGLSDEKDRESPCH--VKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGH 276
Query: 220 LAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQL 279
+ R L+ + VT ++ G T ++AFG GQL
Sbjct: 277 DSMNDEVNPRR---VLELMGSEVT------QIACGRQHTLAFVPSSGLIYAFGCGARGQL 327
Query: 280 GITGEKRKTALFSPTE 295
G TG SP +
Sbjct: 328 G-TGHTCNVKCPSPVK 342
Score = 49.6 bits (113), Expect = 3e-05
Identities = 29/78 (37%), Positives = 38/78 (48%), Gaps = 2/78 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIA-LDSSGKIWT 100
K G V T G G GQLG E + + +G ++ + G HT+A + SSG I+
Sbjct: 259 KSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYA 318
Query: 101 FGCNDEGALGRA-TSNEK 117
FGC G LG T N K
Sbjct: 319 FGCGARGQLGTGHTCNVK 336
>AC098582-1|AAY41038.1| 382|Homo sapiens unknown protein.
Length = 382
Score = 120 bits (289), Expect = 1e-26
Identities = 103/363 (28%), Positives = 170/363 (46%), Gaps = 29/363 (7%)
Query: 46 VLTCGQGDVGQLGLGEDVVETTKFKYVTA-LGDKIV-DVQAGGMHTIALDSSGKIWTFGC 103
+L G +GQ G+ ++ V + D+ V +V GG H++ L G+++T G
Sbjct: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
Query: 104 NDEGALGRATSNEKDEGTPKQ--XXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
N +G LG +E++ P+Q G+SHS AL G +++WG+ S G
Sbjct: 61 NTKGQLG----HEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGA--GSDG 114
Query: 162 SMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLA 221
+GL+ + K++ + ++++ G H + L G FT G GQLG L
Sbjct: 115 QLGLMTTEDSVAVPRLIQKLN-QQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLG-LG 172
Query: 222 QRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGI 281
+ S+ + Q +L + L Q AA G H +F L A +F +G+NN GQLG+
Sbjct: 173 KEFPSQASPQRVRSL---EGIPLAQVAA---GGAH-SFALSLSGA-VFGWGMNNAGQLGL 224
Query: 282 TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLG 341
+ EK + SP LR ++ G+ HT L +G ++ G G+LG
Sbjct: 225 SDEKDRE---SPCHVKLLRT----QKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLG-H 276
Query: 342 DKSGDAETLELIPKLQNKKCISIAAGTSNSFA-VTDSGEVYSWGMGSEGKLGTGESEDLN 400
D D + +L + IA G ++ A V SG +Y++G G+ G+LGTG + ++
Sbjct: 277 DSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVK 336
Query: 401 EPT 403
P+
Sbjct: 337 CPS 339
Score = 101 bits (242), Expect = 6e-21
Identities = 89/304 (29%), Positives = 135/304 (44%), Gaps = 32/304 (10%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWTFG 102
G V TCG GQLG E K + + AL D+ I+ V G H++AL G+++++G
Sbjct: 53 GEVYTCGLNTKGQLGHER---EGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWG 109
Query: 103 CNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
+G LG T+ E P+ Q G+ H AL +G + WG ++SH
Sbjct: 110 AGSDGQLGLMTT-EDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWG--KNSH 166
Query: 161 GSMGLVVRGREGKPCKEPVKIDI--GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLG 218
G +GL G+E P ++ G P ++A+GG H L+ SG VF G GQLG
Sbjct: 167 GQLGL---GKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLG 223
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
++ ++ Q + G T VL + +F FG + GQ
Sbjct: 224 LSDEKDRESPCH---------VKLLRTQKVVYISCGEEHTAVL-TKSGGVFTFGAGSCGQ 273
Query: 279 LGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT-LAANGQIYALGRCEYGR 337
LG + +P L +G + + +A G+ HTL + ++G IYA G G+
Sbjct: 274 LGHDSMNDEV---NPRR--VLELMGSE--VTQIACGRQHTLAFVPSSGLIYAFGCGARGQ 326
Query: 338 LGLG 341
LG G
Sbjct: 327 LGTG 330
Score = 100 bits (239), Expect = 1e-20
Identities = 70/240 (29%), Positives = 118/240 (49%), Gaps = 19/240 (7%)
Query: 189 EIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAA 248
E+A GG+H V L G V+T G +GQLG +R ++ + G A Q
Sbjct: 38 EVACGGNHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGALA---------DQHI 86
Query: 249 ARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAW 308
V G + L + +LF++G + GQLG+ + A+ P L +
Sbjct: 87 IHVACGESHSLAL-SDRGQLFSWGAGSDGQLGLMTTEDSVAV--PRLIQKL----NQQTI 139
Query: 309 SAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGT 368
V+ G H L LAA+GQ + G+ +G+LGLG + + + + L+ +AAG
Sbjct: 140 LQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG 199
Query: 369 SNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT-LAAVDSRAPLRVSAGGQHTVLLVE 427
++SFA++ SG V+ WGM + G+LG + +D P + + ++ + +S G +HT +L +
Sbjct: 200 AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTK 259
Score = 99.5 bits (237), Expect = 2e-20
Identities = 82/292 (28%), Positives = 140/292 (47%), Gaps = 25/292 (8%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREG-KPCKEPVKIDIGEPAVEIASGGD 195
G +HS LL++G+VY G ++ G +G REG KP E + + + +A G
Sbjct: 42 GGNHSVFLLEDGEVYTCGL--NTKGQLG---HEREGNKP--EQIGALADQHIIHVACGES 94
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H + L+ G +F+ G G GQLG + + R + + T+ Q + W H
Sbjct: 95 HSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPR----LIQKLNQQTILQVSCGNW--H 148
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
D Q F +G N++GQLG+ E A SP +L + + VA G
Sbjct: 149 CLALAADGQ---FFTWGKNSHGQLGLGKEFPSQA--SPQRVRSLEGI----PLAQVAAGG 199
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVT 375
H+ L+ +G ++ G G+LGL D+ D E+ + L+ +K + I+ G ++ +T
Sbjct: 200 AHSFALSLSGAVFGWGMNNAGQLGLSDEK-DRESPCHVKLLRTQKVVYISCGEEHTAVLT 258
Query: 376 DSGEVYSWGMGSEGKLG-TGESEDLNEPTLAAVDSRAPLRVSAGGQHTVLLV 426
SG V+++G GS G+LG ++++N + + +++ G QHT+ V
Sbjct: 259 KSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFV 310
Score = 91.1 bits (216), Expect = 8e-18
Identities = 76/256 (29%), Positives = 110/256 (42%), Gaps = 18/256 (7%)
Query: 43 RGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWTF 101
RG++ + G G GQLGL + + L + I+ V G H +AL + G+ +T+
Sbjct: 102 RGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTW 161
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXX--XXXXXGDSHSAALLQNGDVYAWGSFRDS 159
G N G LG + +P++ G +HS AL +G V+ WG ++
Sbjct: 162 GKNSHGQLGLG-KEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGM--NN 218
Query: 160 HGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGR 219
G +GL PC VK+ + V I+ G +H VLT SGGVFT G G GQLG
Sbjct: 219 AGQLGLSDEKDRESPCH--VKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGH 276
Query: 220 LAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQL 279
+ R L+ + VT ++ G T ++AFG GQL
Sbjct: 277 DSMNDEVNPRR---VLELMGSEVT------QIACGRQHTLAFVPSSGLIYAFGCGARGQL 327
Query: 280 GITGEKRKTALFSPTE 295
G TG SP +
Sbjct: 328 G-TGHTCNVKCPSPVK 342
Score = 49.6 bits (113), Expect = 3e-05
Identities = 29/78 (37%), Positives = 38/78 (48%), Gaps = 2/78 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIA-LDSSGKIWT 100
K G V T G G GQLG E + + +G ++ + G HT+A + SSG I+
Sbjct: 259 KSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYA 318
Query: 101 FGCNDEGALGRA-TSNEK 117
FGC G LG T N K
Sbjct: 319 FGCGARGQLGTGHTCNVK 336
>AJ318463-1|CAC86116.1| 815|Homo sapiens retinitis pigmentosa
GTPase regulator protein.
Length = 815
Score = 96.7 bits (230), Expect = 2e-19
Identities = 80/295 (27%), Positives = 146/295 (49%), Gaps = 29/295 (9%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKP-CKEPVKIDIGEPAVEIASGGD 195
GD HSA + N +Y +GS ++ G +GL + KP C + +K E A G +
Sbjct: 43 GDEHSAVVTGNNKLYMFGS--NNWGQLGLGSKSAISKPTCVKALK---PEKVKLAACGRN 97
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H +V T G V+ G +GQLG + R F + + T ++ AG
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGL-----GDTEERNTFHVI---SFFTSEHKIKQLSAGS 149
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ + L + RLF +G N+ GQ+G+ K + + P + +G+ +W ++ G
Sbjct: 150 NTSAAL-TEDGRLFMWGDNSEGQIGL---KNVSNVCVPQQV----TIGNPVSW--ISCGY 199
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKS-GDAETLELIPKLQNKKCISIAAGTSNSFAV 374
+H+ + +G++Y G E G+LGL ++ G+ T +L+ ++ +K I +A G ++ +
Sbjct: 200 YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVL 258
Query: 375 TDSGEVYSWGMGSEGKLGTGESE-DLNEP-TLAAVDSRAPLRVSAGGQHTVLLVE 427
T++ VY++G+G G+LG G + +EP + + + +S G HT L+ +
Sbjct: 259 TENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312
Score = 95.9 bits (228), Expect = 3e-19
Identities = 90/357 (25%), Positives = 157/357 (43%), Gaps = 37/357 (10%)
Query: 77 DKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXX 136
D V + G H+ + + K++ FG N+ G LG + + + T +
Sbjct: 35 DVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAAC 94
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAV-EIASGGD 195
G +H+ + G+VYA G ++ G +GL E + + E + ++++G +
Sbjct: 95 GRNHTLVSTEGGNVYATGG--NNEGQLGL--GDTEERNTFHVISFFTSEHKIKQLSAGSN 150
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
LT G +F G +GQ+G + S + VP +VT+ + + G+
Sbjct: 151 TSAALTEDGRLFMWGDNSEGQIGL-----------KNVSNVCVPQQVTIGNPVSWISCGY 199
Query: 256 -HATFVLDAQHARLFAFGLNNYGQLGIT----GEKRKTALFSPTECDALRAVGDDHAWSA 310
H+ FV L+ FG G+LG+ G R L S ++
Sbjct: 200 YHSAFV--TTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---------- 247
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
VA G HT+ L N +Y G ++G+LGLG + ++I ++++ I+ G ++
Sbjct: 248 VACGGEHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENH 306
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNE--PTLAAVDSRAPLR-VSAGGQHTVL 424
+ +TD G +Y++G G GKLG G N PTL + R ++ V+ GG H V+
Sbjct: 307 TALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVV 363
Score = 77.8 bits (183), Expect = 8e-14
Identities = 72/256 (28%), Positives = 114/256 (44%), Gaps = 21/256 (8%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGD--KIVDVQAGGMHTIALDSSGKIWTF 101
G V G + GQLGLG D E F ++ KI + AG + AL G+++ +
Sbjct: 106 GNVYATGGNNEGQLGLG-DTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMW 164
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
G N EG +G N + P+Q G HSA + +G++Y +G +G
Sbjct: 165 GDNSEGQIG--LKNVSNVCVPQQVTIGNPVSWISCGYYHSAFVTTDGELYVFG--EPENG 220
Query: 162 SMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLA 221
+GL G + +I E +++A GG+H VVL T V+T G G+ GQLG
Sbjct: 221 KLGL-PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGT 278
Query: 222 QRSASRDARQGFSALLVPARVTLRQAAARVWAG-HHATFVLDAQHARLFAFGLNNYGQLG 280
+ + + ++ R Q + + G +H + D ++ FG +G+LG
Sbjct: 279 FLFETSEPK-----VIENIR---DQTISYISCGENHTALITDI--GLMYTFGDGRHGKLG 328
Query: 281 ITGEKRKTALFSPTEC 296
+ G + T F PT C
Sbjct: 329 L-GLENFTNHFIPTLC 343
Score = 64.1 bits (149), Expect = 1e-09
Identities = 70/259 (27%), Positives = 114/259 (44%), Gaps = 24/259 (9%)
Query: 171 EGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDAR 230
E P K K D+ V ++ G +H V+T + ++ G GQLG L +SA ++
Sbjct: 24 ENNPGKFWFKNDV---PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLG-LGSKSAI--SK 77
Query: 231 QGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTAL 290
L P +V L AA G + T V + ++A G NN GQLG+ G+ +
Sbjct: 78 PTCVKALKPEKVKL---AA---CGRNHTLV-STEGGNVYATGGNNEGQLGL-GDTEERNT 129
Query: 291 FSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETL 350
F + +H ++ G + + L +G+++ G G++GL + S
Sbjct: 130 FH-----VISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ 184
Query: 351 ELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNE--PTLAAVD 408
++ I+ G +S VT GE+Y +G GKLG N P L +
Sbjct: 185 QVTI---GNPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI 241
Query: 409 SRAPLRVSAGGQHTVLLVE 427
++V+ GG+HTV+L E
Sbjct: 242 PEKVIQVACGGEHTVVLTE 260
>X97668-1|CAA66258.1| 815|Homo sapiens XLRP3 protein.
Length = 815
Score = 96.3 bits (229), Expect = 2e-19
Identities = 90/357 (25%), Positives = 158/357 (44%), Gaps = 37/357 (10%)
Query: 77 DKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXX 136
D V + G H+ + + K++ FG N+ G LG + + + T +
Sbjct: 35 DVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAAC 94
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAV-EIASGGD 195
G +H+ + G+VYA G ++ G +GL E + + E + ++++G +
Sbjct: 95 GRNHTLVSTEGGNVYATGG--NNEGQLGL--GDTEERNTFHVISFFTSEHKIKQLSAGSN 150
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
LT G +F G +GQ+G + S + VP +VT+ + + + G+
Sbjct: 151 TSAALTEDGRLFMWGDNSEGQIGL-----------KNVSNVCVPQQVTIGKPVSWISCGY 199
Query: 256 -HATFVLDAQHARLFAFGLNNYGQLGIT----GEKRKTALFSPTECDALRAVGDDHAWSA 310
H+ FV L+ FG G+LG+ G R L S ++
Sbjct: 200 YHSAFV--TTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---------- 247
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
VA G HT+ L N +Y G ++G+LGLG + ++I ++++ I+ G ++
Sbjct: 248 VACGGEHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENH 306
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNE--PTLAAVDSRAPLR-VSAGGQHTVL 424
+ +TD G +Y++G G GKLG G N PTL + R ++ V+ GG H V+
Sbjct: 307 TALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVV 363
Score = 95.9 bits (228), Expect = 3e-19
Identities = 80/295 (27%), Positives = 145/295 (49%), Gaps = 29/295 (9%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKP-CKEPVKIDIGEPAVEIASGGD 195
GD HSA + N +Y +GS ++ G +GL + KP C + +K E A G +
Sbjct: 43 GDEHSAVVTGNNKLYMFGS--NNWGQLGLGSKSAISKPTCVKALK---PEKVKLAACGRN 97
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H +V T G V+ G +GQLG + R F + + T ++ AG
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGL-----GDTEERNTFHVI---SFFTSEHKIKQLSAGS 149
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ + L + RLF +G N+ GQ+G+ K + + P + +G +W ++ G
Sbjct: 150 NTSAAL-TEDGRLFMWGDNSEGQIGL---KNVSNVCVPQQV----TIGKPVSW--ISCGY 199
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKS-GDAETLELIPKLQNKKCISIAAGTSNSFAV 374
+H+ + +G++Y G E G+LGL ++ G+ T +L+ ++ +K I +A G ++ +
Sbjct: 200 YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVL 258
Query: 375 TDSGEVYSWGMGSEGKLGTGESE-DLNEP-TLAAVDSRAPLRVSAGGQHTVLLVE 427
T++ VY++G+G G+LG G + +EP + + + +S G HT L+ +
Sbjct: 259 TENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312
Score = 77.8 bits (183), Expect = 8e-14
Identities = 72/256 (28%), Positives = 114/256 (44%), Gaps = 21/256 (8%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGD--KIVDVQAGGMHTIALDSSGKIWTF 101
G V G + GQLGLG D E F ++ KI + AG + AL G+++ +
Sbjct: 106 GNVYATGGNNEGQLGLG-DTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMW 164
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
G N EG +G N + P+Q G HSA + +G++Y +G +G
Sbjct: 165 GDNSEGQIG--LKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFG--EPENG 220
Query: 162 SMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLA 221
+GL G + +I E +++A GG+H VVL T V+T G G+ GQLG
Sbjct: 221 KLGL-PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGT 278
Query: 222 QRSASRDARQGFSALLVPARVTLRQAAARVWAG-HHATFVLDAQHARLFAFGLNNYGQLG 280
+ + + ++ R Q + + G +H + D ++ FG +G+LG
Sbjct: 279 FLFETSEPK-----VIENIR---DQTISYISCGENHTALITDI--GLMYTFGDGRHGKLG 328
Query: 281 ITGEKRKTALFSPTEC 296
+ G + T F PT C
Sbjct: 329 L-GLENFTNHFIPTLC 343
Score = 66.1 bits (154), Expect = 3e-10
Identities = 71/259 (27%), Positives = 115/259 (44%), Gaps = 24/259 (9%)
Query: 171 EGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDAR 230
E P K K D+ V ++ G +H V+T + ++ G GQLG L +SA ++
Sbjct: 24 ENNPGKFWFKNDV---PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLG-LGSKSAI--SK 77
Query: 231 QGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTAL 290
L P +V L AA G + T V + ++A G NN GQLG+ G+ +
Sbjct: 78 PTCVKALKPEKVKL---AA---CGRNHTLV-STEGGNVYATGGNNEGQLGL-GDTEERNT 129
Query: 291 FSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETL 350
F + +H ++ G + + L +G+++ G G++GL + S
Sbjct: 130 FH-----VISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ 184
Query: 351 ELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNE--PTLAAVD 408
++ K I+ G +S VT GE+Y +G GKLG N P L +
Sbjct: 185 QVTI---GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI 241
Query: 409 SRAPLRVSAGGQHTVLLVE 427
++V+ GG+HTV+L E
Sbjct: 242 PEKVIQVACGGEHTVVLTE 260
>U57629-1|AAC50481.1| 815|Homo sapiens retinitis pigmentosa GTPase
regulator protein.
Length = 815
Score = 96.3 bits (229), Expect = 2e-19
Identities = 90/357 (25%), Positives = 158/357 (44%), Gaps = 37/357 (10%)
Query: 77 DKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXX 136
D V + G H+ + + K++ FG N+ G LG + + + T +
Sbjct: 35 DVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAAC 94
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAV-EIASGGD 195
G +H+ + G+VYA G ++ G +GL E + + E + ++++G +
Sbjct: 95 GRNHTLVSTEGGNVYATGG--NNEGQLGL--GDTEERNTFHVISFFTSEHKIKQLSAGSN 150
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
LT G +F G +GQ+G + S + VP +VT+ + + + G+
Sbjct: 151 TSAALTEDGRLFMWGDNSEGQIGL-----------KNVSNVCVPQQVTIGKPVSWISCGY 199
Query: 256 -HATFVLDAQHARLFAFGLNNYGQLGIT----GEKRKTALFSPTECDALRAVGDDHAWSA 310
H+ FV L+ FG G+LG+ G R L S ++
Sbjct: 200 YHSAFV--TTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---------- 247
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
VA G HT+ L N +Y G ++G+LGLG + ++I ++++ I+ G ++
Sbjct: 248 VACGGEHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENH 306
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNE--PTLAAVDSRAPLR-VSAGGQHTVL 424
+ +TD G +Y++G G GKLG G N PTL + R ++ V+ GG H V+
Sbjct: 307 TALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVV 363
Score = 95.9 bits (228), Expect = 3e-19
Identities = 80/295 (27%), Positives = 145/295 (49%), Gaps = 29/295 (9%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKP-CKEPVKIDIGEPAVEIASGGD 195
GD HSA + N +Y +GS ++ G +GL + KP C + +K E A G +
Sbjct: 43 GDEHSAVVTGNNKLYMFGS--NNWGQLGLGSKSAISKPTCVKALK---PEKVKLAACGRN 97
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H +V T G V+ G +GQLG + R F + + T ++ AG
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGL-----GDTEERNTFHVI---SFFTSEHKIKQLSAGS 149
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ + L + RLF +G N+ GQ+G+ K + + P + +G +W ++ G
Sbjct: 150 NTSAAL-TEDGRLFMWGDNSEGQIGL---KNVSNVCVPQQV----TIGKPVSW--ISCGY 199
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKS-GDAETLELIPKLQNKKCISIAAGTSNSFAV 374
+H+ + +G++Y G E G+LGL ++ G+ T +L+ ++ +K I +A G ++ +
Sbjct: 200 YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVL 258
Query: 375 TDSGEVYSWGMGSEGKLGTGESE-DLNEP-TLAAVDSRAPLRVSAGGQHTVLLVE 427
T++ VY++G+G G+LG G + +EP + + + +S G HT L+ +
Sbjct: 259 TENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312
Score = 77.8 bits (183), Expect = 8e-14
Identities = 72/256 (28%), Positives = 114/256 (44%), Gaps = 21/256 (8%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGD--KIVDVQAGGMHTIALDSSGKIWTF 101
G V G + GQLGLG D E F ++ KI + AG + AL G+++ +
Sbjct: 106 GNVYATGGNNEGQLGLG-DTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMW 164
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
G N EG +G N + P+Q G HSA + +G++Y +G +G
Sbjct: 165 GDNSEGQIG--LKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFG--EPENG 220
Query: 162 SMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLA 221
+GL G + +I E +++A GG+H VVL T V+T G G+ GQLG
Sbjct: 221 KLGL-PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGT 278
Query: 222 QRSASRDARQGFSALLVPARVTLRQAAARVWAG-HHATFVLDAQHARLFAFGLNNYGQLG 280
+ + + ++ R Q + + G +H + D ++ FG +G+LG
Sbjct: 279 FLFETSEPK-----VIENIR---DQTISYISCGENHTALITDI--GLMYTFGDGRHGKLG 328
Query: 281 ITGEKRKTALFSPTEC 296
+ G + T F PT C
Sbjct: 329 L-GLENFTNHFIPTLC 343
Score = 66.1 bits (154), Expect = 3e-10
Identities = 71/259 (27%), Positives = 115/259 (44%), Gaps = 24/259 (9%)
Query: 171 EGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDAR 230
E P K K D+ V ++ G +H V+T + ++ G GQLG L +SA ++
Sbjct: 24 ENNPGKFWFKNDV---PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLG-LGSKSAI--SK 77
Query: 231 QGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTAL 290
L P +V L AA G + T V + ++A G NN GQLG+ G+ +
Sbjct: 78 PTCVKALKPEKVKL---AA---CGRNHTLV-STEGGNVYATGGNNEGQLGL-GDTEERNT 129
Query: 291 FSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETL 350
F + +H ++ G + + L +G+++ G G++GL + S
Sbjct: 130 FH-----VISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ 184
Query: 351 ELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNE--PTLAAVD 408
++ K I+ G +S VT GE+Y +G GKLG N P L +
Sbjct: 185 QVTI---GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI 241
Query: 409 SRAPLRVSAGGQHTVLLVE 427
++V+ GG+HTV+L E
Sbjct: 242 PEKVIQVACGGEHTVVLTE 260
>BC031624-1|AAH31624.1| 480|Homo sapiens RPGR protein protein.
Length = 480
Score = 96.3 bits (229), Expect = 2e-19
Identities = 90/357 (25%), Positives = 158/357 (44%), Gaps = 37/357 (10%)
Query: 77 DKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXX 136
D V + G H+ + + K++ FG N+ G LG + + + T +
Sbjct: 35 DVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAAC 94
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAV-EIASGGD 195
G +H+ + G+VYA G ++ G +GL E + + E + ++++G +
Sbjct: 95 GRNHTLVSTEGGNVYATGG--NNEGQLGL--GDTEERNTFHVISFFTSEHKIKQLSAGSN 150
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
LT G +F G +GQ+G + S + VP +VT+ + + + G+
Sbjct: 151 TSAALTEDGRLFMWGDNSEGQIGL-----------KNVSNVCVPQQVTIGKPVSWISCGY 199
Query: 256 -HATFVLDAQHARLFAFGLNNYGQLGIT----GEKRKTALFSPTECDALRAVGDDHAWSA 310
H+ FV L+ FG G+LG+ G R L S ++
Sbjct: 200 YHSAFV--TTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---------- 247
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
VA G HT+ L N +Y G ++G+LGLG + ++I ++++ I+ G ++
Sbjct: 248 VACGGEHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENH 306
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNE--PTLAAVDSRAPLR-VSAGGQHTVL 424
+ +TD G +Y++G G GKLG G N PTL + R ++ V+ GG H V+
Sbjct: 307 TALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVV 363
Score = 95.9 bits (228), Expect = 3e-19
Identities = 80/295 (27%), Positives = 145/295 (49%), Gaps = 29/295 (9%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKP-CKEPVKIDIGEPAVEIASGGD 195
GD HSA + N +Y +GS ++ G +GL + KP C + +K E A G +
Sbjct: 43 GDEHSAVVTGNNKLYMFGS--NNWGQLGLGSKSAISKPTCVKALK---PEKVKLAACGRN 97
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H +V T G V+ G +GQLG + R F + + T ++ AG
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGL-----GDTEERNTFHVI---SFFTSEHKIKQLSAGS 149
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ + L + RLF +G N+ GQ+G+ K + + P + +G +W ++ G
Sbjct: 150 NTSAAL-TEDGRLFMWGDNSEGQIGL---KNVSNVCVPQQV----TIGKPVSW--ISCGY 199
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKS-GDAETLELIPKLQNKKCISIAAGTSNSFAV 374
+H+ + +G++Y G E G+LGL ++ G+ T +L+ ++ +K I +A G ++ +
Sbjct: 200 YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVL 258
Query: 375 TDSGEVYSWGMGSEGKLGTGESE-DLNEP-TLAAVDSRAPLRVSAGGQHTVLLVE 427
T++ VY++G+G G+LG G + +EP + + + +S G HT L+ +
Sbjct: 259 TENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312
Score = 77.8 bits (183), Expect = 8e-14
Identities = 72/256 (28%), Positives = 114/256 (44%), Gaps = 21/256 (8%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGD--KIVDVQAGGMHTIALDSSGKIWTF 101
G V G + GQLGLG D E F ++ KI + AG + AL G+++ +
Sbjct: 106 GNVYATGGNNEGQLGLG-DTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMW 164
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
G N EG +G N + P+Q G HSA + +G++Y +G +G
Sbjct: 165 GDNSEGQIG--LKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFG--EPENG 220
Query: 162 SMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLA 221
+GL G + +I E +++A GG+H VVL T V+T G G+ GQLG
Sbjct: 221 KLGL-PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGT 278
Query: 222 QRSASRDARQGFSALLVPARVTLRQAAARVWAG-HHATFVLDAQHARLFAFGLNNYGQLG 280
+ + + ++ R Q + + G +H + D ++ FG +G+LG
Sbjct: 279 FLFETSEPK-----VIENIR---DQTISYISCGENHTALITDI--GLMYTFGDGRHGKLG 328
Query: 281 ITGEKRKTALFSPTEC 296
+ G + T F PT C
Sbjct: 329 L-GLENFTNHFIPTLC 343
Score = 66.1 bits (154), Expect = 3e-10
Identities = 71/259 (27%), Positives = 115/259 (44%), Gaps = 24/259 (9%)
Query: 171 EGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDAR 230
E P K K D+ V ++ G +H V+T + ++ G GQLG L +SA ++
Sbjct: 24 ENNPGKFWFKNDV---PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLG-LGSKSAI--SK 77
Query: 231 QGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTAL 290
L P +V L AA G + T V + ++A G NN GQLG+ G+ +
Sbjct: 78 PTCVKALKPEKVKL---AA---CGRNHTLV-STEGGNVYATGGNNEGQLGL-GDTEERNT 129
Query: 291 FSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETL 350
F + +H ++ G + + L +G+++ G G++GL + S
Sbjct: 130 FH-----VISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ 184
Query: 351 ELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNE--PTLAAVD 408
++ K I+ G +S VT GE+Y +G GKLG N P L +
Sbjct: 185 QVTI---GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI 241
Query: 409 SRAPLRVSAGGQHTVLLVE 427
++V+ GG+HTV+L E
Sbjct: 242 PEKVIQVACGGEHTVVLTE 260
>AL606748-2|CAI95407.1| 815|Homo sapiens retinitis pigmentosa
GTPase regulator protein.
Length = 815
Score = 96.3 bits (229), Expect = 2e-19
Identities = 90/357 (25%), Positives = 158/357 (44%), Gaps = 37/357 (10%)
Query: 77 DKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXX 136
D V + G H+ + + K++ FG N+ G LG + + + T +
Sbjct: 35 DVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAAC 94
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAV-EIASGGD 195
G +H+ + G+VYA G ++ G +GL E + + E + ++++G +
Sbjct: 95 GRNHTLVSTEGGNVYATGG--NNEGQLGL--GDTEERNTFHVISFFTSEHKIKQLSAGSN 150
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
LT G +F G +GQ+G + S + VP +VT+ + + + G+
Sbjct: 151 TSAALTEDGRLFMWGDNSEGQIGL-----------KNVSNVCVPQQVTIGKPVSWISCGY 199
Query: 256 -HATFVLDAQHARLFAFGLNNYGQLGIT----GEKRKTALFSPTECDALRAVGDDHAWSA 310
H+ FV L+ FG G+LG+ G R L S ++
Sbjct: 200 YHSAFV--TTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---------- 247
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
VA G HT+ L N +Y G ++G+LGLG + ++I ++++ I+ G ++
Sbjct: 248 VACGGEHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENH 306
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNE--PTLAAVDSRAPLR-VSAGGQHTVL 424
+ +TD G +Y++G G GKLG G N PTL + R ++ V+ GG H V+
Sbjct: 307 TALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVV 363
Score = 95.9 bits (228), Expect = 3e-19
Identities = 80/295 (27%), Positives = 145/295 (49%), Gaps = 29/295 (9%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKP-CKEPVKIDIGEPAVEIASGGD 195
GD HSA + N +Y +GS ++ G +GL + KP C + +K E A G +
Sbjct: 43 GDEHSAVVTGNNKLYMFGS--NNWGQLGLGSKSAISKPTCVKALK---PEKVKLAACGRN 97
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H +V T G V+ G +GQLG + R F + + T ++ AG
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGL-----GDTEERNTFHVI---SFFTSEHKIKQLSAGS 149
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ + L + RLF +G N+ GQ+G+ K + + P + +G +W ++ G
Sbjct: 150 NTSAAL-TEDGRLFMWGDNSEGQIGL---KNVSNVCVPQQV----TIGKPVSW--ISCGY 199
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKS-GDAETLELIPKLQNKKCISIAAGTSNSFAV 374
+H+ + +G++Y G E G+LGL ++ G+ T +L+ ++ +K I +A G ++ +
Sbjct: 200 YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVL 258
Query: 375 TDSGEVYSWGMGSEGKLGTGESE-DLNEP-TLAAVDSRAPLRVSAGGQHTVLLVE 427
T++ VY++G+G G+LG G + +EP + + + +S G HT L+ +
Sbjct: 259 TENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312
Score = 77.8 bits (183), Expect = 8e-14
Identities = 72/256 (28%), Positives = 114/256 (44%), Gaps = 21/256 (8%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGD--KIVDVQAGGMHTIALDSSGKIWTF 101
G V G + GQLGLG D E F ++ KI + AG + AL G+++ +
Sbjct: 106 GNVYATGGNNEGQLGLG-DTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMW 164
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
G N EG +G N + P+Q G HSA + +G++Y +G +G
Sbjct: 165 GDNSEGQIG--LKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFG--EPENG 220
Query: 162 SMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLA 221
+GL G + +I E +++A GG+H VVL T V+T G G+ GQLG
Sbjct: 221 KLGL-PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGT 278
Query: 222 QRSASRDARQGFSALLVPARVTLRQAAARVWAG-HHATFVLDAQHARLFAFGLNNYGQLG 280
+ + + ++ R Q + + G +H + D ++ FG +G+LG
Sbjct: 279 FLFETSEPK-----VIENIR---DQTISYISCGENHTALITDI--GLMYTFGDGRHGKLG 328
Query: 281 ITGEKRKTALFSPTEC 296
+ G + T F PT C
Sbjct: 329 L-GLENFTNHFIPTLC 343
Score = 66.1 bits (154), Expect = 3e-10
Identities = 71/259 (27%), Positives = 115/259 (44%), Gaps = 24/259 (9%)
Query: 171 EGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDAR 230
E P K K D+ V ++ G +H V+T + ++ G GQLG L +SA ++
Sbjct: 24 ENNPGKFWFKNDV---PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLG-LGSKSAI--SK 77
Query: 231 QGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTAL 290
L P +V L AA G + T V + ++A G NN GQLG+ G+ +
Sbjct: 78 PTCVKALKPEKVKL---AA---CGRNHTLV-STEGGNVYATGGNNEGQLGL-GDTEERNT 129
Query: 291 FSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETL 350
F + +H ++ G + + L +G+++ G G++GL + S
Sbjct: 130 FH-----VISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ 184
Query: 351 ELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNE--PTLAAVD 408
++ K I+ G +S VT GE+Y +G GKLG N P L +
Sbjct: 185 QVTI---GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI 241
Query: 409 SRAPLRVSAGGQHTVLLVE 427
++V+ GG+HTV+L E
Sbjct: 242 PEKVIQVACGGEHTVVLTE 260
>AK223491-1|BAD97211.1| 815|Homo sapiens retinitis pigmentosa
GTPase regulator variant protein.
Length = 815
Score = 96.3 bits (229), Expect = 2e-19
Identities = 90/357 (25%), Positives = 158/357 (44%), Gaps = 37/357 (10%)
Query: 77 DKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXX 136
D V + G H+ + + K++ FG N+ G LG + + + T +
Sbjct: 35 DVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAAC 94
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAV-EIASGGD 195
G +H+ + G+VYA G ++ G +GL E + + E + ++++G +
Sbjct: 95 GRNHTLVSTEGGNVYATGG--NNEGQLGL--GDTEERNTFHVISFFTSEHKIKQLSAGSN 150
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
LT G +F G +GQ+G + S + VP +VT+ + + + G+
Sbjct: 151 TSAALTEDGRLFMWGDNSEGQIGL-----------KNVSNVCVPQQVTIGKPVSWISCGY 199
Query: 256 -HATFVLDAQHARLFAFGLNNYGQLGIT----GEKRKTALFSPTECDALRAVGDDHAWSA 310
H+ FV L+ FG G+LG+ G R L S ++
Sbjct: 200 YHSAFV--TTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---------- 247
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
VA G HT+ L N +Y G ++G+LGLG + ++I ++++ I+ G ++
Sbjct: 248 VACGGEHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENH 306
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNE--PTLAAVDSRAPLR-VSAGGQHTVL 424
+ +TD G +Y++G G GKLG G N PTL + R ++ V+ GG H V+
Sbjct: 307 TALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVV 363
Score = 95.9 bits (228), Expect = 3e-19
Identities = 80/295 (27%), Positives = 145/295 (49%), Gaps = 29/295 (9%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKP-CKEPVKIDIGEPAVEIASGGD 195
GD HSA + N +Y +GS ++ G +GL + KP C + +K E A G +
Sbjct: 43 GDEHSAVVTGNNKLYMFGS--NNWGQLGLGSKSAISKPTCVKALK---PEKVKLAACGRN 97
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H +V T G V+ G +GQLG + R F + + T ++ AG
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGL-----GDTEERNTFHVI---SFFTSEHKIKQLSAGS 149
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ + L + RLF +G N+ GQ+G+ K + + P + +G +W ++ G
Sbjct: 150 NTSAAL-TEDGRLFMWGDNSEGQIGL---KNVSNVCVPQQV----TIGKPVSW--ISCGY 199
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKS-GDAETLELIPKLQNKKCISIAAGTSNSFAV 374
+H+ + +G++Y G E G+LGL ++ G+ T +L+ ++ +K I +A G ++ +
Sbjct: 200 YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVL 258
Query: 375 TDSGEVYSWGMGSEGKLGTGESE-DLNEP-TLAAVDSRAPLRVSAGGQHTVLLVE 427
T++ VY++G+G G+LG G + +EP + + + +S G HT L+ +
Sbjct: 259 TENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312
Score = 77.8 bits (183), Expect = 8e-14
Identities = 72/256 (28%), Positives = 114/256 (44%), Gaps = 21/256 (8%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGD--KIVDVQAGGMHTIALDSSGKIWTF 101
G V G + GQLGLG D E F ++ KI + AG + AL G+++ +
Sbjct: 106 GNVYATGGNNEGQLGLG-DTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMW 164
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
G N EG +G N + P+Q G HSA + +G++Y +G +G
Sbjct: 165 GDNSEGQIG--LKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFG--EPENG 220
Query: 162 SMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLA 221
+GL G + +I E +++A GG+H VVL T V+T G G+ GQLG
Sbjct: 221 KLGL-PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGT 278
Query: 222 QRSASRDARQGFSALLVPARVTLRQAAARVWAG-HHATFVLDAQHARLFAFGLNNYGQLG 280
+ + + ++ R Q + + G +H + D ++ FG +G+LG
Sbjct: 279 FLFETSEPK-----VIENIR---DQTISYISCGENHTALITDI--GLMYTFGDGRHGKLG 328
Query: 281 ITGEKRKTALFSPTEC 296
+ G + T F PT C
Sbjct: 329 L-GLENFTNHFIPTLC 343
Score = 66.1 bits (154), Expect = 3e-10
Identities = 71/259 (27%), Positives = 115/259 (44%), Gaps = 24/259 (9%)
Query: 171 EGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDAR 230
E P K K D+ V ++ G +H V+T + ++ G GQLG L +SA ++
Sbjct: 24 ENNPGKFWFKNDV---PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLG-LGSKSAI--SK 77
Query: 231 QGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTAL 290
L P +V L AA G + T V + ++A G NN GQLG+ G+ +
Sbjct: 78 PTCVKALKPEKVKL---AA---CGRNHTLV-STEGGNVYATGGNNEGQLGL-GDTEERNT 129
Query: 291 FSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETL 350
F + +H ++ G + + L +G+++ G G++GL + S
Sbjct: 130 FH-----VISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ 184
Query: 351 ELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNE--PTLAAVD 408
++ K I+ G +S VT GE+Y +G GKLG N P L +
Sbjct: 185 QVTI---GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI 241
Query: 409 SRAPLRVSAGGQHTVLLVE 427
++V+ GG+HTV+L E
Sbjct: 242 PEKVIQVACGGEHTVVLTE 260
>AJ238395-1|CAB54002.1| 646|Homo sapiens RPGR protein protein.
Length = 646
Score = 96.3 bits (229), Expect = 2e-19
Identities = 90/357 (25%), Positives = 158/357 (44%), Gaps = 37/357 (10%)
Query: 77 DKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXX 136
D V + G H+ + + K++ FG N+ G LG + + + T +
Sbjct: 35 DVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAAC 94
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAV-EIASGGD 195
G +H+ + G+VYA G ++ G +GL E + + E + ++++G +
Sbjct: 95 GRNHTLVSTEGGNVYATGG--NNEGQLGL--GDTEERNTFHVISFFTSEHKIKQLSAGSN 150
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
LT G +F G +GQ+G + S + VP +VT+ + + + G+
Sbjct: 151 TSAALTEDGRLFMWGDNSEGQIGL-----------KNVSNVCVPQQVTIGKPVSWISCGY 199
Query: 256 -HATFVLDAQHARLFAFGLNNYGQLGIT----GEKRKTALFSPTECDALRAVGDDHAWSA 310
H+ FV L+ FG G+LG+ G R L S ++
Sbjct: 200 YHSAFV--TTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---------- 247
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
VA G HT+ L N +Y G ++G+LGLG + ++I ++++ I+ G ++
Sbjct: 248 VACGGEHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENH 306
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNE--PTLAAVDSRAPLR-VSAGGQHTVL 424
+ +TD G +Y++G G GKLG G N PTL + R ++ V+ GG H V+
Sbjct: 307 TALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVV 363
Score = 95.9 bits (228), Expect = 3e-19
Identities = 80/295 (27%), Positives = 145/295 (49%), Gaps = 29/295 (9%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKP-CKEPVKIDIGEPAVEIASGGD 195
GD HSA + N +Y +GS ++ G +GL + KP C + +K E A G +
Sbjct: 43 GDEHSAVVTGNNKLYMFGS--NNWGQLGLGSKSAISKPTCVKALK---PEKVKLAACGRN 97
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H +V T G V+ G +GQLG + R F + + T ++ AG
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGL-----GDTEERNTFHVI---SFFTSEHKIKQLSAGS 149
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ + L + RLF +G N+ GQ+G+ K + + P + +G +W ++ G
Sbjct: 150 NTSAAL-TEDGRLFMWGDNSEGQIGL---KNVSNVCVPQQV----TIGKPVSW--ISCGY 199
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKS-GDAETLELIPKLQNKKCISIAAGTSNSFAV 374
+H+ + +G++Y G E G+LGL ++ G+ T +L+ ++ +K I +A G ++ +
Sbjct: 200 YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVL 258
Query: 375 TDSGEVYSWGMGSEGKLGTGESE-DLNEP-TLAAVDSRAPLRVSAGGQHTVLLVE 427
T++ VY++G+G G+LG G + +EP + + + +S G HT L+ +
Sbjct: 259 TENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITD 312
Score = 77.8 bits (183), Expect = 8e-14
Identities = 72/256 (28%), Positives = 114/256 (44%), Gaps = 21/256 (8%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGD--KIVDVQAGGMHTIALDSSGKIWTF 101
G V G + GQLGLG D E F ++ KI + AG + AL G+++ +
Sbjct: 106 GNVYATGGNNEGQLGLG-DTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMW 164
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
G N EG +G N + P+Q G HSA + +G++Y +G +G
Sbjct: 165 GDNSEGQIG--LKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFG--EPENG 220
Query: 162 SMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLA 221
+GL G + +I E +++A GG+H VVL T V+T G G+ GQLG
Sbjct: 221 KLGL-PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGT 278
Query: 222 QRSASRDARQGFSALLVPARVTLRQAAARVWAG-HHATFVLDAQHARLFAFGLNNYGQLG 280
+ + + ++ R Q + + G +H + D ++ FG +G+LG
Sbjct: 279 FLFETSEPK-----VIENIR---DQTISYISCGENHTALITDI--GLMYTFGDGRHGKLG 328
Query: 281 ITGEKRKTALFSPTEC 296
+ G + T F PT C
Sbjct: 329 L-GLENFTNHFIPTLC 343
Score = 66.1 bits (154), Expect = 3e-10
Identities = 71/259 (27%), Positives = 115/259 (44%), Gaps = 24/259 (9%)
Query: 171 EGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDAR 230
E P K K D+ V ++ G +H V+T + ++ G GQLG L +SA ++
Sbjct: 24 ENNPGKFWFKNDV---PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLG-LGSKSAI--SK 77
Query: 231 QGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTAL 290
L P +V L AA G + T V + ++A G NN GQLG+ G+ +
Sbjct: 78 PTCVKALKPEKVKL---AA---CGRNHTLV-STEGGNVYATGGNNEGQLGL-GDTEERNT 129
Query: 291 FSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETL 350
F + +H ++ G + + L +G+++ G G++GL + S
Sbjct: 130 FH-----VISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ 184
Query: 351 ELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNE--PTLAAVD 408
++ K I+ G +S VT GE+Y +G GKLG N P L +
Sbjct: 185 QVTI---GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEI 241
Query: 409 SRAPLRVSAGGQHTVLLVE 427
++V+ GG+HTV+L E
Sbjct: 242 PEKVIQVACGGEHTVVLTE 260
>AF225407-1|AAO27483.1| 409|Homo sapiens HERC2 protein.
Length = 409
Score = 93.9 bits (223), Expect = 1e-18
Identities = 73/252 (28%), Positives = 115/252 (45%), Gaps = 19/252 (7%)
Query: 191 ASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAAR 250
A+GG H +T +G ++T G G G+LG D+ LV A R
Sbjct: 1 AAGGAHSACVTAAGDLYTWGKGRYGRLGH-------SDSEDQLKPKLVEALQGHRVVDIA 53
Query: 251 VWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSA 310
+G T L ++++G +YG+LG G P + D+L +G
Sbjct: 54 CGSGDAQTLCLTDDDT-VWSWGDGDYGKLGRGGSDGCKV---PMKIDSLTGLGV----VK 105
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
V G ++ L +G +Y G+ +Y RLG G + + LQ KK I+IA G+ +
Sbjct: 106 VECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQ-VQGLQGKKVIAIATGSLH 164
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTL-AAVDSRAPLRVSAGGQHTVL--LVE 427
T+ GEVY+WG EG+LG G + + P L AA+ + RV+ G HT+ +
Sbjct: 165 CVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSK 224
Query: 428 ETSSQREPSPIP 439
S+ + P+ +P
Sbjct: 225 PASAGKLPAQVP 236
Score = 74.1 bits (174), Expect = 1e-12
Identities = 58/181 (32%), Positives = 81/181 (44%), Gaps = 14/181 (7%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGG--MHTIALDSSGKIWT 100
G + T G+G G+LG D + K K V AL G ++VD+ G T+ L +W+
Sbjct: 14 GDLYTWGKGRYGRLG-HSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWS 72
Query: 101 FGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGS---FR 157
+G D G LGR S+ G S AL ++G VY WG R
Sbjct: 73 WGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHR 132
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQL 217
HGS V R R+ + + G+ + IA+G H V T G V+T G ++GQL
Sbjct: 133 LGHGSDDHVRRPRQVQGLQ-------GKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQL 185
Query: 218 G 218
G
Sbjct: 186 G 186
Score = 60.1 bits (139), Expect = 2e-08
Identities = 42/139 (30%), Positives = 66/139 (47%), Gaps = 10/139 (7%)
Query: 84 AGGMHTIALDSSGKIWTFGCNDEGALGRATSNE--KDEGTPKQXXXXXXXXXXXXGDSHS 141
AGG H+ + ++G ++T+G G LG + S + K + GD+ +
Sbjct: 2 AGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQT 61
Query: 142 AALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVV 199
L + V++WG +G +G G +G CK P+KID G V++ G V
Sbjct: 62 LCLTDDDTVWSWGD--GDYGKLGR--GGSDG--CKVPMKIDSLTGLGVVKVECGSQFSVA 115
Query: 200 LTTSGGVFTLGCGEQGQLG 218
LT SG V+T G G+ +LG
Sbjct: 116 LTKSGAVYTWGKGDYHRLG 134
Score = 55.6 bits (128), Expect = 4e-07
Identities = 40/158 (25%), Positives = 62/158 (39%), Gaps = 4/158 (2%)
Query: 46 VLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGCND 105
V + G GD G+LG G K + G +V V+ G ++AL SG ++T+G D
Sbjct: 70 VWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGD 129
Query: 106 EGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGL 165
LG + + Q G H ++G+VY WG + G +G
Sbjct: 130 YHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGD--NDEGQLGD 187
Query: 166 VVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTS 203
+P V G+ +A G H + +TS
Sbjct: 188 GTTNAIQRP--RLVAALQGKKVNRVACGSAHTLAWSTS 223
Score = 55.2 bits (127), Expect = 5e-07
Identities = 29/82 (35%), Positives = 44/82 (53%), Gaps = 2/82 (2%)
Query: 35 EIPTAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALD 93
+ A K G V T G+GD +LG G D + + V L G K++ + G +H +
Sbjct: 111 QFSVALTKSGAVYTWGKGDYHRLGHGSD-DHVRRPRQVQGLQGKKVIAIATGSLHCVCCT 169
Query: 94 SSGKIWTFGCNDEGALGRATSN 115
G+++T+G NDEG LG T+N
Sbjct: 170 EDGEVYTWGDNDEGQLGDGTTN 191
>AF224249-1|AAO27475.1| 328|Homo sapiens HERC2 protein.
Length = 328
Score = 93.5 bits (222), Expect = 2e-18
Identities = 85/301 (28%), Positives = 134/301 (44%), Gaps = 26/301 (8%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGD---KIVDVQAGGMHTIALDSSGKIWT 100
G+V CG+ G+LGLG + +TAL K V V +GG H AL GK++
Sbjct: 49 GKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFW 108
Query: 101 FGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
+G D+G LG + D+ + G SHSAAL +G++Y WG +
Sbjct: 109 WGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWG--LGEY 166
Query: 161 GSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGG--DHLVVLTTSGGVFTLGCGEQGQLG 218
G +G + KP + VK+ +G +++A G + LT G VF+ G G+ G+LG
Sbjct: 167 GRLGHGDNTTQLKP--KMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLG 224
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
R S + Q L Q ++ G + L + ++ +G +Y +
Sbjct: 225 R--GGSEGCNIPQNIERL-------NGQGVCQIECGAQFSLAL-TKSGVVWTWGKGDYFR 274
Query: 279 LGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRL 338
LG + + P + LR H VA+G H L + +GQ+YA G ++G+
Sbjct: 275 LGHGSD---VHVRKPQVVEGLRGKKIVH----VAVGALHCLAVTDSGQVYAWGDNDHGQQ 327
Query: 339 G 339
G
Sbjct: 328 G 328
Score = 91.5 bits (217), Expect = 6e-18
Identities = 95/350 (27%), Positives = 142/350 (40%), Gaps = 31/350 (8%)
Query: 50 GQGDVGQLG-LGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGA 108
G D QLG L ++ F T +V V G A+ GK++ G G
Sbjct: 3 GLNDKDQLGGLKGSKIKVPSFSE-TLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGR 61
Query: 109 LGRATSNEKDEGTPKQXXXXXXXX----XXXXGDSHSAALLQNGDVYAWGSFRDSHGSMG 164
LG S+ P+Q G H+ AL +G V+ WG D G +G
Sbjct: 62 LGLGISSGTVP-IPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFWWGEGDD--GKLG 118
Query: 165 LVVRGREGKP-CKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQR 223
R KP E +K + +IA G H LT+SG ++T G GE G+LG
Sbjct: 119 HFSRMNCDKPRLIEALKT---KRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGH---- 171
Query: 224 SASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLD-AQHARLFAFGLNNYGQLGIT 282
D +V +V L +V G L +F++G ++G+LG
Sbjct: 172 ---GDNTTQLKPKMV--KVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 226
Query: 283 GEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGD 342
G + P + L G + G +L L +G ++ G+ +Y RLG G
Sbjct: 227 GSEGCNI---PQNIERLNGQGV----CQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGS 279
Query: 343 KSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLG 392
+++ L+ KK + +A G + AVTDSG+VY+WG G+ G
Sbjct: 280 DV-HVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQG 328
Score = 87.8 bits (208), Expect = 8e-17
Identities = 70/245 (28%), Positives = 116/245 (47%), Gaps = 22/245 (8%)
Query: 188 VEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQA 247
V++A G L +T G V+ G G+LG L S + + +AL + +++
Sbjct: 33 VQVAGGSKSLFAVTVEGKVYACGEATNGRLG-LGISSGTVPIPRQITAL---SSYVVKKV 88
Query: 248 AARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVG--DD 305
A G HAT + ++F +G + G+LG FS CD R +
Sbjct: 89 AVHS-GGRHATAL--TVDGKVFWWGEGDDGKLGH---------FSRMNCDKPRLIEALKT 136
Query: 306 HAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIA 365
+A G H+ L ++G++Y G EYGRLG GD + + +++ L + I +A
Sbjct: 137 KRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKP-KMVKVLLGHRVIQVA 195
Query: 366 AGT--SNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEP-TLAAVDSRAPLRVSAGGQHT 422
G+ + + A+TD G V+SWG G GKLG G SE N P + ++ + ++ G Q +
Sbjct: 196 CGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFS 255
Query: 423 VLLVE 427
+ L +
Sbjct: 256 LALTK 260
Score = 85.4 bits (202), Expect = 4e-16
Identities = 83/331 (25%), Positives = 132/331 (39%), Gaps = 24/331 (7%)
Query: 101 FGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
+G ND+ LG ++ + + G A+ G VYA G ++
Sbjct: 2 WGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEA--TN 59
Query: 161 GSMGL-VVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGR 219
G +GL + G P + V + SGG H LT G VF G G+ G+LG
Sbjct: 60 GRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFWWGEGDDGKLGH 119
Query: 220 LAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQL 279
++ + + L+ A T R + H A + L+ +GL YG+L
Sbjct: 120 FSRMNCDKPR-------LIEALKTKRIRDIACGSSHSAALTSSGE---LYTWGLGEYGRL 169
Query: 280 GITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQH--HTLTLAANGQIYALGRCEYGR 337
G G+ T P L H VA G TL L G +++ G ++G+
Sbjct: 170 G-HGDN--TTQLKPKMVKVLLG----HRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGK 222
Query: 338 LGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESE 397
LG G G + I +L + I G S A+T SG V++WG G +LG G
Sbjct: 223 LGRGGSEG-CNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDV 281
Query: 398 DLNEP-TLAAVDSRAPLRVSAGGQHTVLLVE 427
+ +P + + + + V+ G H + + +
Sbjct: 282 HVRKPQVVEGLRGKKIVHVAVGALHCLAVTD 312
Score = 66.9 bits (156), Expect = 2e-10
Identities = 57/186 (30%), Positives = 85/186 (45%), Gaps = 12/186 (6%)
Query: 38 TAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSG 96
TA G+V G+GD G+LG + K + + AL K I D+ G H+ AL SSG
Sbjct: 98 TALTVDGKVFWWGEGDDGKLG-HFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSG 156
Query: 97 KIWTFGCNDEGALGRA--TSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWG 154
+++T+G + G LG T+ K + D+ + AL G V++WG
Sbjct: 157 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWG 216
Query: 155 SFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLGCG 212
G G + RG + C P I+ G+ +I G + LT SG V+T G G
Sbjct: 217 D-----GDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKG 270
Query: 213 EQGQLG 218
+ +LG
Sbjct: 271 DYFRLG 276
Score = 51.6 bits (118), Expect = 6e-06
Identities = 30/70 (42%), Positives = 40/70 (57%), Gaps = 2/70 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWT 100
K G V T G+GD +LG G D V K + V L G KIV V G +H +A+ SG+++
Sbjct: 260 KSGVVWTWGKGDYFRLGHGSD-VHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYA 318
Query: 101 FGCNDEGALG 110
+G ND G G
Sbjct: 319 WGDNDHGQQG 328
>BC042047-1|AAH42047.2| 1022|Homo sapiens hect domain and RLD 6
protein.
Length = 1022
Score = 90.6 bits (215), Expect = 1e-17
Identities = 71/250 (28%), Positives = 124/250 (49%), Gaps = 22/250 (8%)
Query: 184 GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRL-AQRSASRDARQGFSALLVPARV 242
G ++ ASG H ++L T+ V + G +GQLGR AQR + Q L+V
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDL-- 79
Query: 243 TLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAV 302
V G + + R+FA+G + GQLGI GE ++ + F+P + L
Sbjct: 80 --------VSCGKEHSLAV-CHKGRVFAWGAGSEGQLGI-GEFKEIS-FTPKKIMTL--- 125
Query: 303 GDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCI 362
+D V+ G +H+L L+ + Q+++ G+ +G+LGLG + + + + L+
Sbjct: 126 -NDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLA 184
Query: 363 SIAAGTSNSFAVTDSGEVYSWGMGSEGKL---GTGESEDLNEP-TLAAVDSRAPLRVSAG 418
+AAG ++SFA++ G + WG S G+L G N+P ++ A+ + + +S G
Sbjct: 185 QVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCG 244
Query: 419 GQHTVLLVEE 428
HT +L ++
Sbjct: 245 DAHTAVLTQD 254
Score = 84.2 bits (199), Expect = 1e-15
Identities = 92/296 (31%), Positives = 129/296 (43%), Gaps = 34/296 (11%)
Query: 45 RVLTCGQGDVGQLG-LGEDVVETTKFKYVTALGDKIVD-VQAGGMHTIALDSSGKIWTFG 102
RVL+CG GQLG G E + + AL IVD V G H++A+ G+++ +G
Sbjct: 43 RVLSCGDNSRGQLGRRGAQRGELP--EPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWG 100
Query: 103 CNDEGALGRATSNEKDEGTPKQ--XXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
EG LG E TPK+ G HS AL ++ V++WG ++SH
Sbjct: 101 AGSEGQLGIGEFKE-ISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWG--KNSH 157
Query: 161 GSMGLVVRGREGKPCKEPVKIDI--GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLG 218
G +GL G+E P ++ G P ++A+GG H L+ G F G GQL
Sbjct: 158 GQLGL---GKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLA 214
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
L+ R+ + + S V A L + G T VL Q ++F FG N GQ
Sbjct: 215 -LSGRNVPVQSNKPLS---VGALKNL--GVVYISCGDAHTAVL-TQDGKVFTFGDNRSGQ 267
Query: 279 LGI--TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT-LAANGQIYALG 331
LG T EKR L D S + G +HTL + GQ+ + G
Sbjct: 268 LGYSPTPEKRGPQLVERI----------DGLVSQIDCGSYHTLAYVHTTGQVVSFG 313
Score = 83.4 bits (197), Expect = 2e-15
Identities = 86/344 (25%), Positives = 148/344 (43%), Gaps = 21/344 (6%)
Query: 60 GEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDE 119
G D E + + + G +++ +G H++ L ++ ++ + G N G LGR + +
Sbjct: 6 GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL 65
Query: 120 GTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGL-VVRGREGKPCKEP 178
P Q G HS A+ G V+AWG+ S G +G+ + P K
Sbjct: 66 PEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGA--GSEGQLGIGEFKEISFTPKKIM 123
Query: 179 VKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLV 238
DI ++++ G H + L+ VF+ G GQLG L + S+ + Q +L
Sbjct: 124 TLNDI--KIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLG-LGKEFPSQASPQRVRSL-- 178
Query: 239 PARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDA 298
+ L Q AA G H +F L + F +G N+ GQL ++G P A
Sbjct: 179 -EGIPLAQVAA---GGAH-SFAL-SLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGA 232
Query: 299 LRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQN 358
L+ +G + ++ G HT L +G+++ G G+LG + + +L+ ++
Sbjct: 233 LKNLGVVY----ISCGDAHTAVLTQDGKVFTFGDNRSGQLGY-SPTPEKRGPQLVERIDG 287
Query: 359 KKCISIAAGTSNSFA-VTDSGEVYSWGMGSEGKLGTGESEDLNE 401
I G+ ++ A V +G+V S+G G E L E
Sbjct: 288 -LVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSKPTHPEALTE 330
Score = 81.4 bits (192), Expect = 7e-15
Identities = 59/182 (32%), Positives = 83/182 (45%), Gaps = 11/182 (6%)
Query: 43 RGRVLTCGQGDVGQLGLGE-DVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+GRV G G GQLG+GE + T K +T KI+ V G H++AL +++++
Sbjct: 93 KGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSW 152
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXX--XXXXXXGDSHSAALLQNGDVYAWGSFRDS 159
G N G LG + +P++ G +HS AL G + WGS +S
Sbjct: 153 GKNSHGQLGLG-KEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGS--NS 209
Query: 160 HGSMGLVVRG---REGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQ 216
G + L R + KP ++G V I+ G H VLT G VFT G GQ
Sbjct: 210 AGQLALSGRNVPVQSNKPLSVGALKNLG--VVYISCGDAHTAVLTQDGKVFTFGDNRSGQ 267
Query: 217 LG 218
LG
Sbjct: 268 LG 269
Score = 79.8 bits (188), Expect = 2e-14
Identities = 73/296 (24%), Positives = 137/296 (46%), Gaps = 23/296 (7%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIAS-GGD 195
G+ HS LL N V + G +S G +G RG + EP++ + V++ S G +
Sbjct: 31 GERHSLLLLTNHRVLSCGD--NSRGQLGR--RGAQRGELPEPIQA-LETLIVDLVSCGKE 85
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H + + G VF G G +GQLG + S ++ ++ + + Q + GH
Sbjct: 86 HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKK----IMTLNDIKIIQVSC----GH 137
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ + L ++ +++F++G N++GQLG+ E A SP +L + + VA G
Sbjct: 138 YHSLAL-SKDSQVFSWGKNSHGQLGLGKEFPSQA--SPQRVRSLEGI----PLAQVAAGG 190
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLE--LIPKLQNKKCISIAAGTSNSFA 373
H+ L+ G + G G+L L ++ ++ + + L+N + I+ G +++
Sbjct: 191 AHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAV 250
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTVLLVEET 429
+T G+V+++G G+LG + + P L ++ G HT+ V T
Sbjct: 251 LTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTT 306
Score = 54.0 bits (124), Expect = 1e-06
Identities = 39/130 (30%), Positives = 59/130 (45%), Gaps = 6/130 (4%)
Query: 39 APKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGK 97
A K +V + G+ GQLGLG++ + V +L G + V AGG H+ AL G
Sbjct: 142 ALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGT 201
Query: 98 IWTFGCNDEGAL---GRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWG 154
+ +G N G L GR + ++ GD+H+A L Q+G V+ +G
Sbjct: 202 SFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFG 261
Query: 155 SFRDSHGSMG 164
R G +G
Sbjct: 262 DNRS--GQLG 269
>AY653203-1|AAV66897.1| 322|Homo sapiens truncated HERC6 protein.
Length = 322
Score = 90.6 bits (215), Expect = 1e-17
Identities = 71/250 (28%), Positives = 124/250 (49%), Gaps = 22/250 (8%)
Query: 184 GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRL-AQRSASRDARQGFSALLVPARV 242
G ++ ASG H ++L T+ V + G +GQLGR AQR + Q L+V
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDL-- 79
Query: 243 TLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAV 302
V G + + R+FA+G + GQLGI GE ++ + F+P + L
Sbjct: 80 --------VSCGKEHSLAV-CHKGRVFAWGAGSEGQLGI-GEFKEIS-FTPKKIMTL--- 125
Query: 303 GDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCI 362
+D V+ G +H+L L+ + Q+++ G+ +G+LGLG + + + + L+
Sbjct: 126 -NDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLA 184
Query: 363 SIAAGTSNSFAVTDSGEVYSWGMGSEGKL---GTGESEDLNEP-TLAAVDSRAPLRVSAG 418
+AAG ++SFA++ G + WG S G+L G N+P ++ A+ + + +S G
Sbjct: 185 QVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCG 244
Query: 419 GQHTVLLVEE 428
HT +L ++
Sbjct: 245 DAHTAVLTQD 254
Score = 83.0 bits (196), Expect = 2e-15
Identities = 82/250 (32%), Positives = 114/250 (45%), Gaps = 23/250 (9%)
Query: 45 RVLTCGQGDVGQLG-LGEDVVETTKFKYVTALGDKIVD-VQAGGMHTIALDSSGKIWTFG 102
RVL+CG GQLG G E + + AL IVD V G H++A+ G+++ +G
Sbjct: 43 RVLSCGDNSRGQLGRRGAQRGELP--EPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWG 100
Query: 103 CNDEGALGRATSNEKDEGTPKQ--XXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
EG LG E TPK+ G HS AL ++ V++WG ++SH
Sbjct: 101 AGSEGQLGIGEFKE-ISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWG--KNSH 157
Query: 161 GSMGLVVRGREGKPCKEPVKIDI--GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLG 218
G +GL G+E P ++ G P ++A+GG H L+ G F G GQL
Sbjct: 158 GQLGL---GKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLA 214
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
L+ R+ + + S V A L + G T VL Q ++F FG N GQ
Sbjct: 215 -LSGRNVPVQSNKPLS---VGALKNL--GVVYISCGDAHTAVL-TQDGKVFTFGDNRSGQ 267
Query: 279 LGI--TGEKR 286
LG T EKR
Sbjct: 268 LGYSPTPEKR 277
Score = 81.4 bits (192), Expect = 7e-15
Identities = 59/182 (32%), Positives = 83/182 (45%), Gaps = 11/182 (6%)
Query: 43 RGRVLTCGQGDVGQLGLGE-DVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+GRV G G GQLG+GE + T K +T KI+ V G H++AL +++++
Sbjct: 93 KGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSW 152
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXX--XXXXXXGDSHSAALLQNGDVYAWGSFRDS 159
G N G LG + +P++ G +HS AL G + WGS +S
Sbjct: 153 GKNSHGQLGLG-KEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGS--NS 209
Query: 160 HGSMGLVVRG---REGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQ 216
G + L R + KP ++G V I+ G H VLT G VFT G GQ
Sbjct: 210 AGQLALSGRNVPVQSNKPLSVGALKNLG--VVYISCGDAHTAVLTQDGKVFTFGDNRSGQ 267
Query: 217 LG 218
LG
Sbjct: 268 LG 269
Score = 79.8 bits (188), Expect = 2e-14
Identities = 73/281 (25%), Positives = 123/281 (43%), Gaps = 18/281 (6%)
Query: 60 GEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDE 119
G D E + + + G +++ +G H++ L ++ ++ + G N G LGR + +
Sbjct: 6 GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL 65
Query: 120 GTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGL-VVRGREGKPCKEP 178
P Q G HS A+ G V+AWG+ S G +G+ + P K
Sbjct: 66 PEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGA--GSEGQLGIGEFKEISFTPKKIM 123
Query: 179 VKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLV 238
DI ++++ G H + L+ VF+ G GQLG L + S+ + Q +L
Sbjct: 124 TLNDI--KIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLG-LGKEFPSQASPQRVRSL-- 178
Query: 239 PARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDA 298
+ L Q AA G H +F L + F +G N+ GQL ++G P A
Sbjct: 179 -EGIPLAQVAA---GGAH-SFAL-SLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGA 232
Query: 299 LRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLG 339
L+ +G + ++ G HT L +G+++ G G+LG
Sbjct: 233 LKNLGVVY----ISCGDAHTAVLTQDGKVFTFGDNRSGQLG 269
Score = 73.7 bits (173), Expect = 1e-12
Identities = 68/271 (25%), Positives = 129/271 (47%), Gaps = 23/271 (8%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIAS-GGD 195
G+ HS LL N V + G +S G +G RG + EP++ + V++ S G +
Sbjct: 31 GERHSLLLLTNHRVLSCGD--NSRGQLGR--RGAQRGELPEPIQA-LETLIVDLVSCGKE 85
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H + + G VF G G +GQLG + S ++ ++ + + Q + GH
Sbjct: 86 HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKK----IMTLNDIKIIQVSC----GH 137
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ + L ++ +++F++G N++GQLG+ E A SP +L + + VA G
Sbjct: 138 YHSLAL-SKDSQVFSWGKNSHGQLGLGKEFPSQA--SPQRVRSLEGI----PLAQVAAGG 190
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLE--LIPKLQNKKCISIAAGTSNSFA 373
H+ L+ G + G G+L L ++ ++ + + L+N + I+ G +++
Sbjct: 191 AHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAV 250
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTL 404
+T G+V+++G G+LG + + P L
Sbjct: 251 LTQDGKVFTFGDNRSGQLGYSPTPEKRGPQL 281
Score = 54.0 bits (124), Expect = 1e-06
Identities = 39/130 (30%), Positives = 59/130 (45%), Gaps = 6/130 (4%)
Query: 39 APKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGK 97
A K +V + G+ GQLGLG++ + V +L G + V AGG H+ AL G
Sbjct: 142 ALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGT 201
Query: 98 IWTFGCNDEGAL---GRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWG 154
+ +G N G L GR + ++ GD+H+A L Q+G V+ +G
Sbjct: 202 SFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFG 261
Query: 155 SFRDSHGSMG 164
R G +G
Sbjct: 262 DNRS--GQLG 269
>AY653202-1|AAV66896.1| 364|Homo sapiens truncated HERC6 protein.
Length = 364
Score = 90.6 bits (215), Expect = 1e-17
Identities = 71/250 (28%), Positives = 124/250 (49%), Gaps = 22/250 (8%)
Query: 184 GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRL-AQRSASRDARQGFSALLVPARV 242
G ++ ASG H ++L T+ V + G +GQLGR AQR + Q L+V
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDL-- 79
Query: 243 TLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAV 302
V G + + R+FA+G + GQLGI GE ++ + F+P + L
Sbjct: 80 --------VSCGKEHSLAV-CHKGRVFAWGAGSEGQLGI-GEFKEIS-FTPKKIMTL--- 125
Query: 303 GDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCI 362
+D V+ G +H+L L+ + Q+++ G+ +G+LGLG + + + + L+
Sbjct: 126 -NDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLA 184
Query: 363 SIAAGTSNSFAVTDSGEVYSWGMGSEGKL---GTGESEDLNEP-TLAAVDSRAPLRVSAG 418
+AAG ++SFA++ G + WG S G+L G N+P ++ A+ + + +S G
Sbjct: 185 QVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCG 244
Query: 419 GQHTVLLVEE 428
HT +L ++
Sbjct: 245 DAHTAVLTQD 254
Score = 84.2 bits (199), Expect = 1e-15
Identities = 92/296 (31%), Positives = 129/296 (43%), Gaps = 34/296 (11%)
Query: 45 RVLTCGQGDVGQLG-LGEDVVETTKFKYVTALGDKIVD-VQAGGMHTIALDSSGKIWTFG 102
RVL+CG GQLG G E + + AL IVD V G H++A+ G+++ +G
Sbjct: 43 RVLSCGDNSRGQLGRRGAQRGELP--EPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWG 100
Query: 103 CNDEGALGRATSNEKDEGTPKQ--XXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
EG LG E TPK+ G HS AL ++ V++WG ++SH
Sbjct: 101 AGSEGQLGIGEFKE-ISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWG--KNSH 157
Query: 161 GSMGLVVRGREGKPCKEPVKIDI--GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLG 218
G +GL G+E P ++ G P ++A+GG H L+ G F G GQL
Sbjct: 158 GQLGL---GKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLA 214
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
L+ R+ + + S V A L + G T VL Q ++F FG N GQ
Sbjct: 215 -LSGRNVPVQSNKPLS---VGALKNL--GVVYISCGDAHTAVL-TQDGKVFTFGDNRSGQ 267
Query: 279 LGI--TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT-LAANGQIYALG 331
LG T EKR L D S + G +HTL + GQ+ + G
Sbjct: 268 LGYSPTPEKRGPQLVERI----------DGLVSQIDCGSYHTLAYVHTTGQVVSFG 313
Score = 83.4 bits (197), Expect = 2e-15
Identities = 86/344 (25%), Positives = 148/344 (43%), Gaps = 21/344 (6%)
Query: 60 GEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDE 119
G D E + + + G +++ +G H++ L ++ ++ + G N G LGR + +
Sbjct: 6 GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL 65
Query: 120 GTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGL-VVRGREGKPCKEP 178
P Q G HS A+ G V+AWG+ S G +G+ + P K
Sbjct: 66 PEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGA--GSEGQLGIGEFKEISFTPKKIM 123
Query: 179 VKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLV 238
DI ++++ G H + L+ VF+ G GQLG L + S+ + Q +L
Sbjct: 124 TLNDI--KIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLG-LGKEFPSQASPQRVRSL-- 178
Query: 239 PARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDA 298
+ L Q AA G H +F L + F +G N+ GQL ++G P A
Sbjct: 179 -EGIPLAQVAA---GGAH-SFAL-SLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGA 232
Query: 299 LRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQN 358
L+ +G + ++ G HT L +G+++ G G+LG + + +L+ ++
Sbjct: 233 LKNLGVVY----ISCGDAHTAVLTQDGKVFTFGDNRSGQLGY-SPTPEKRGPQLVERIDG 287
Query: 359 KKCISIAAGTSNSFA-VTDSGEVYSWGMGSEGKLGTGESEDLNE 401
I G+ ++ A V +G+V S+G G E L E
Sbjct: 288 -LVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSKPTHPEALTE 330
Score = 81.4 bits (192), Expect = 7e-15
Identities = 59/182 (32%), Positives = 83/182 (45%), Gaps = 11/182 (6%)
Query: 43 RGRVLTCGQGDVGQLGLGE-DVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+GRV G G GQLG+GE + T K +T KI+ V G H++AL +++++
Sbjct: 93 KGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSW 152
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXX--XXXXXXGDSHSAALLQNGDVYAWGSFRDS 159
G N G LG + +P++ G +HS AL G + WGS +S
Sbjct: 153 GKNSHGQLGLG-KEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGS--NS 209
Query: 160 HGSMGLVVRG---REGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQ 216
G + L R + KP ++G V I+ G H VLT G VFT G GQ
Sbjct: 210 AGQLALSGRNVPVQSNKPLSVGALKNLG--VVYISCGDAHTAVLTQDGKVFTFGDNRSGQ 267
Query: 217 LG 218
LG
Sbjct: 268 LG 269
Score = 79.8 bits (188), Expect = 2e-14
Identities = 73/296 (24%), Positives = 137/296 (46%), Gaps = 23/296 (7%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIAS-GGD 195
G+ HS LL N V + G +S G +G RG + EP++ + V++ S G +
Sbjct: 31 GERHSLLLLTNHRVLSCGD--NSRGQLGR--RGAQRGELPEPIQA-LETLIVDLVSCGKE 85
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H + + G VF G G +GQLG + S ++ ++ + + Q + GH
Sbjct: 86 HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKK----IMTLNDIKIIQVSC----GH 137
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ + L ++ +++F++G N++GQLG+ E A SP +L + + VA G
Sbjct: 138 YHSLAL-SKDSQVFSWGKNSHGQLGLGKEFPSQA--SPQRVRSLEGI----PLAQVAAGG 190
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLE--LIPKLQNKKCISIAAGTSNSFA 373
H+ L+ G + G G+L L ++ ++ + + L+N + I+ G +++
Sbjct: 191 AHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAV 250
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTVLLVEET 429
+T G+V+++G G+LG + + P L ++ G HT+ V T
Sbjct: 251 LTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTT 306
Score = 54.0 bits (124), Expect = 1e-06
Identities = 39/130 (30%), Positives = 59/130 (45%), Gaps = 6/130 (4%)
Query: 39 APKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGK 97
A K +V + G+ GQLGLG++ + V +L G + V AGG H+ AL G
Sbjct: 142 ALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGT 201
Query: 98 IWTFGCNDEGAL---GRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWG 154
+ +G N G L GR + ++ GD+H+A L Q+G V+ +G
Sbjct: 202 SFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFG 261
Query: 155 SFRDSHGSMG 164
R G +G
Sbjct: 262 DNRS--GQLG 269
>AY653201-1|AAV66895.1| 986|Homo sapiens HERC6 splice variant
protein.
Length = 986
Score = 90.6 bits (215), Expect = 1e-17
Identities = 71/250 (28%), Positives = 124/250 (49%), Gaps = 22/250 (8%)
Query: 184 GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRL-AQRSASRDARQGFSALLVPARV 242
G ++ ASG H ++L T+ V + G +GQLGR AQR + Q L+V
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDL-- 79
Query: 243 TLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAV 302
V G + + R+FA+G + GQLGI GE ++ + F+P + L
Sbjct: 80 --------VSCGKEHSLAV-CHKGRVFAWGAGSEGQLGI-GEFKEIS-FTPKKIMTL--- 125
Query: 303 GDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCI 362
+D V+ G +H+L L+ + Q+++ G+ +G+LGLG + + + + L+
Sbjct: 126 -NDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLA 184
Query: 363 SIAAGTSNSFAVTDSGEVYSWGMGSEGKL---GTGESEDLNEP-TLAAVDSRAPLRVSAG 418
+AAG ++SFA++ G + WG S G+L G N+P ++ A+ + + +S G
Sbjct: 185 QVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCG 244
Query: 419 GQHTVLLVEE 428
HT +L ++
Sbjct: 245 DAHTAVLTQD 254
Score = 84.2 bits (199), Expect = 1e-15
Identities = 92/296 (31%), Positives = 129/296 (43%), Gaps = 34/296 (11%)
Query: 45 RVLTCGQGDVGQLG-LGEDVVETTKFKYVTALGDKIVD-VQAGGMHTIALDSSGKIWTFG 102
RVL+CG GQLG G E + + AL IVD V G H++A+ G+++ +G
Sbjct: 43 RVLSCGDNSRGQLGRRGAQRGELP--EPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWG 100
Query: 103 CNDEGALGRATSNEKDEGTPKQ--XXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
EG LG E TPK+ G HS AL ++ V++WG ++SH
Sbjct: 101 AGSEGQLGIGEFKE-ISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWG--KNSH 157
Query: 161 GSMGLVVRGREGKPCKEPVKIDI--GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLG 218
G +GL G+E P ++ G P ++A+GG H L+ G F G GQL
Sbjct: 158 GQLGL---GKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLA 214
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
L+ R+ + + S V A L + G T VL Q ++F FG N GQ
Sbjct: 215 -LSGRNVPVQSNKPLS---VGALKNL--GVVYISCGDAHTAVL-TQDGKVFTFGDNRSGQ 267
Query: 279 LGI--TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT-LAANGQIYALG 331
LG T EKR L D S + G +HTL + GQ+ + G
Sbjct: 268 LGYSPTPEKRGPQLVERI----------DGLVSQIDCGSYHTLAYVHTTGQVVSFG 313
Score = 83.4 bits (197), Expect = 2e-15
Identities = 86/344 (25%), Positives = 148/344 (43%), Gaps = 21/344 (6%)
Query: 60 GEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDE 119
G D E + + + G +++ +G H++ L ++ ++ + G N G LGR + +
Sbjct: 6 GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL 65
Query: 120 GTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGL-VVRGREGKPCKEP 178
P Q G HS A+ G V+AWG+ S G +G+ + P K
Sbjct: 66 PEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGA--GSEGQLGIGEFKEISFTPKKIM 123
Query: 179 VKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLV 238
DI ++++ G H + L+ VF+ G GQLG L + S+ + Q +L
Sbjct: 124 TLNDI--KIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLG-LGKEFPSQASPQRVRSL-- 178
Query: 239 PARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDA 298
+ L Q AA G H +F L + F +G N+ GQL ++G P A
Sbjct: 179 -EGIPLAQVAA---GGAH-SFAL-SLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGA 232
Query: 299 LRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQN 358
L+ +G + ++ G HT L +G+++ G G+LG + + +L+ ++
Sbjct: 233 LKNLGVVY----ISCGDAHTAVLTQDGKVFTFGDNRSGQLGY-SPTPEKRGPQLVERIDG 287
Query: 359 KKCISIAAGTSNSFA-VTDSGEVYSWGMGSEGKLGTGESEDLNE 401
I G+ ++ A V +G+V S+G G E L E
Sbjct: 288 -LVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSKPTHPEALTE 330
Score = 81.4 bits (192), Expect = 7e-15
Identities = 59/182 (32%), Positives = 83/182 (45%), Gaps = 11/182 (6%)
Query: 43 RGRVLTCGQGDVGQLGLGE-DVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+GRV G G GQLG+GE + T K +T KI+ V G H++AL +++++
Sbjct: 93 KGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSW 152
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXX--XXXXXXGDSHSAALLQNGDVYAWGSFRDS 159
G N G LG + +P++ G +HS AL G + WGS +S
Sbjct: 153 GKNSHGQLGLG-KEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGS--NS 209
Query: 160 HGSMGLVVRG---REGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQ 216
G + L R + KP ++G V I+ G H VLT G VFT G GQ
Sbjct: 210 AGQLALSGRNVPVQSNKPLSVGALKNLG--VVYISCGDAHTAVLTQDGKVFTFGDNRSGQ 267
Query: 217 LG 218
LG
Sbjct: 268 LG 269
Score = 79.8 bits (188), Expect = 2e-14
Identities = 73/296 (24%), Positives = 137/296 (46%), Gaps = 23/296 (7%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIAS-GGD 195
G+ HS LL N V + G +S G +G RG + EP++ + V++ S G +
Sbjct: 31 GERHSLLLLTNHRVLSCGD--NSRGQLGR--RGAQRGELPEPIQA-LETLIVDLVSCGKE 85
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H + + G VF G G +GQLG + S ++ ++ + + Q + GH
Sbjct: 86 HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKK----IMTLNDIKIIQVSC----GH 137
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ + L ++ +++F++G N++GQLG+ E A SP +L + + VA G
Sbjct: 138 YHSLAL-SKDSQVFSWGKNSHGQLGLGKEFPSQA--SPQRVRSLEGI----PLAQVAAGG 190
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLE--LIPKLQNKKCISIAAGTSNSFA 373
H+ L+ G + G G+L L ++ ++ + + L+N + I+ G +++
Sbjct: 191 AHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAV 250
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTVLLVEET 429
+T G+V+++G G+LG + + P L ++ G HT+ V T
Sbjct: 251 LTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTT 306
Score = 54.0 bits (124), Expect = 1e-06
Identities = 39/130 (30%), Positives = 59/130 (45%), Gaps = 6/130 (4%)
Query: 39 APKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGK 97
A K +V + G+ GQLGLG++ + V +L G + V AGG H+ AL G
Sbjct: 142 ALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGT 201
Query: 98 IWTFGCNDEGAL---GRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWG 154
+ +G N G L GR + ++ GD+H+A L Q+G V+ +G
Sbjct: 202 SFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFG 261
Query: 155 SFRDSHGSMG 164
R G +G
Sbjct: 262 DNRS--GQLG 269
>AF336798-1|AAQ14893.1| 1022|Homo sapiens HERC6 protein.
Length = 1022
Score = 90.6 bits (215), Expect = 1e-17
Identities = 71/250 (28%), Positives = 124/250 (49%), Gaps = 22/250 (8%)
Query: 184 GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRL-AQRSASRDARQGFSALLVPARV 242
G ++ ASG H ++L T+ V + G +GQLGR AQR + Q L+V
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDL-- 79
Query: 243 TLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAV 302
V G + + R+FA+G + GQLGI GE ++ + F+P + L
Sbjct: 80 --------VSCGKEHSLAV-CHKGRVFAWGAGSEGQLGI-GEFKEIS-FTPKKIMTL--- 125
Query: 303 GDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCI 362
+D V+ G +H+L L+ + Q+++ G+ +G+LGLG + + + + L+
Sbjct: 126 -NDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLA 184
Query: 363 SIAAGTSNSFAVTDSGEVYSWGMGSEGKL---GTGESEDLNEP-TLAAVDSRAPLRVSAG 418
+AAG ++SFA++ G + WG S G+L G N+P ++ A+ + + +S G
Sbjct: 185 QVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCG 244
Query: 419 GQHTVLLVEE 428
HT +L ++
Sbjct: 245 DAHTAVLTQD 254
Score = 84.2 bits (199), Expect = 1e-15
Identities = 92/296 (31%), Positives = 129/296 (43%), Gaps = 34/296 (11%)
Query: 45 RVLTCGQGDVGQLG-LGEDVVETTKFKYVTALGDKIVD-VQAGGMHTIALDSSGKIWTFG 102
RVL+CG GQLG G E + + AL IVD V G H++A+ G+++ +G
Sbjct: 43 RVLSCGDNSRGQLGRRGAQRGELP--EPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWG 100
Query: 103 CNDEGALGRATSNEKDEGTPKQ--XXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
EG LG E TPK+ G HS AL ++ V++WG ++SH
Sbjct: 101 AGSEGQLGIGEFKE-ISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWG--KNSH 157
Query: 161 GSMGLVVRGREGKPCKEPVKIDI--GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLG 218
G +GL G+E P ++ G P ++A+GG H L+ G F G GQL
Sbjct: 158 GQLGL---GKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLA 214
Query: 219 RLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQ 278
L+ R+ + + S V A L + G T VL Q ++F FG N GQ
Sbjct: 215 -LSGRNVPVQSNKPLS---VGALKNL--GVVYISCGDAHTAVL-TQDGKVFTFGDNRSGQ 267
Query: 279 LGI--TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT-LAANGQIYALG 331
LG T EKR L D S + G +HTL + GQ+ + G
Sbjct: 268 LGYSPTPEKRGPQLVERI----------DGLVSQIDCGSYHTLAYVHTTGQVVSFG 313
Score = 83.4 bits (197), Expect = 2e-15
Identities = 86/344 (25%), Positives = 148/344 (43%), Gaps = 21/344 (6%)
Query: 60 GEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDE 119
G D E + + + G +++ +G H++ L ++ ++ + G N G LGR + +
Sbjct: 6 GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL 65
Query: 120 GTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGL-VVRGREGKPCKEP 178
P Q G HS A+ G V+AWG+ S G +G+ + P K
Sbjct: 66 PEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGA--GSEGQLGIGEFKEISFTPKKIM 123
Query: 179 VKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLV 238
DI ++++ G H + L+ VF+ G GQLG L + S+ + Q +L
Sbjct: 124 TLNDI--KIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLG-LGKEFPSQASPQRVRSL-- 178
Query: 239 PARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDA 298
+ L Q AA G H +F L + F +G N+ GQL ++G P A
Sbjct: 179 -EGIPLAQVAA---GGAH-SFAL-SLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGA 232
Query: 299 LRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQN 358
L+ +G + ++ G HT L +G+++ G G+LG + + +L+ ++
Sbjct: 233 LKNLGVVY----ISCGDAHTAVLTQDGKVFTFGDNRSGQLGY-SPTPEKRGPQLVERIDG 287
Query: 359 KKCISIAAGTSNSFA-VTDSGEVYSWGMGSEGKLGTGESEDLNE 401
I G+ ++ A V +G+V S+G G E L E
Sbjct: 288 -LVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSKPTHPEALTE 330
Score = 81.4 bits (192), Expect = 7e-15
Identities = 59/182 (32%), Positives = 83/182 (45%), Gaps = 11/182 (6%)
Query: 43 RGRVLTCGQGDVGQLGLGE-DVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+GRV G G GQLG+GE + T K +T KI+ V G H++AL +++++
Sbjct: 93 KGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSW 152
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXX--XXXXXXGDSHSAALLQNGDVYAWGSFRDS 159
G N G LG + +P++ G +HS AL G + WGS +S
Sbjct: 153 GKNSHGQLGLG-KEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGS--NS 209
Query: 160 HGSMGLVVRG---REGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQ 216
G + L R + KP ++G V I+ G H VLT G VFT G GQ
Sbjct: 210 AGQLALSGRNVPVQSNKPLSVGALKNLG--VVYISCGDAHTAVLTQDGKVFTFGDNRSGQ 267
Query: 217 LG 218
LG
Sbjct: 268 LG 269
Score = 79.8 bits (188), Expect = 2e-14
Identities = 73/296 (24%), Positives = 137/296 (46%), Gaps = 23/296 (7%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIAS-GGD 195
G+ HS LL N V + G +S G +G RG + EP++ + V++ S G +
Sbjct: 31 GERHSLLLLTNHRVLSCGD--NSRGQLGR--RGAQRGELPEPIQA-LETLIVDLVSCGKE 85
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H + + G VF G G +GQLG + S ++ ++ + + Q + GH
Sbjct: 86 HSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKK----IMTLNDIKIIQVSC----GH 137
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ + L ++ +++F++G N++GQLG+ E A SP +L + + VA G
Sbjct: 138 YHSLAL-SKDSQVFSWGKNSHGQLGLGKEFPSQA--SPQRVRSLEGI----PLAQVAAGG 190
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLE--LIPKLQNKKCISIAAGTSNSFA 373
H+ L+ G + G G+L L ++ ++ + + L+N + I+ G +++
Sbjct: 191 AHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAV 250
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTVLLVEET 429
+T G+V+++G G+LG + + P L ++ G HT+ V T
Sbjct: 251 LTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTT 306
Score = 54.0 bits (124), Expect = 1e-06
Identities = 39/130 (30%), Positives = 59/130 (45%), Gaps = 6/130 (4%)
Query: 39 APKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGK 97
A K +V + G+ GQLGLG++ + V +L G + V AGG H+ AL G
Sbjct: 142 ALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGT 201
Query: 98 IWTFGCNDEGAL---GRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWG 154
+ +G N G L GR + ++ GD+H+A L Q+G V+ +G
Sbjct: 202 SFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFG 261
Query: 155 SFRDSHGSMG 164
R G +G
Sbjct: 262 DNRS--GQLG 269
>BC112101-1|AAI12102.1| 979|Homo sapiens NIMA related kinase 9
protein.
Length = 979
Score = 89.8 bits (213), Expect = 2e-17
Identities = 83/315 (26%), Positives = 143/315 (45%), Gaps = 35/315 (11%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGG 194
GD + + G +YA+GS D +G MG V G EP++++ + P +++ G
Sbjct: 434 GDDFTVCVTDEGQLYAFGS--DYYGCMG--VDKVAGPEVLEPMQLNFFLSNPVEQVSCGD 489
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQA--AARVW 252
+H+VVLT + V++ GCGE G+LG D+ + + P +V + +A V
Sbjct: 490 NHVVVLTRNKEVYSWGCGEYGRLG--------LDSEEDY---YTPQKVDVPKALIIVAVQ 538
Query: 253 AGHHATFVLDAQHARLFAFGLNNYGQLGI----TGEKRKTALFSP--TECDALRAVGDDH 306
G TF+L Q ++ A GLN + +LG+ +G A T L +
Sbjct: 539 CGCDGTFLL-TQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFY 597
Query: 307 AWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA 366
+A G+ HT + G++ G + G+LG+G+ L L K+ I ++
Sbjct: 598 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657
Query: 367 GTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL--------RVSAG 418
G + A TD +++WG G G+L +E + + R P+ +S
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPR-PIFGSLHHVPDLSCR 716
Query: 419 GQHTVLLVEETSSQR 433
G HT+L+VE+ + +
Sbjct: 717 GWHTILIVEKVLNSK 731
Score = 60.1 bits (139), Expect = 2e-08
Identities = 70/309 (22%), Positives = 134/309 (43%), Gaps = 34/309 (11%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDS---HGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASG 193
G++H A + ++Y W + + HG +G + +P K K+ G+ +++ G
Sbjct: 377 GNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQP-KHVEKLQ-GKAIRQVSCG 434
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
D V +T G ++ G G +G + A + + L +V
Sbjct: 435 DDFTVCVTDEGQLYAFGSDYYGCMG--VDKVAGPEVLEPMQL-----NFFLSNPVEQVSC 487
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
G + VL ++ ++++G YG+LG+ E+ ++P + D +A+ AV
Sbjct: 488 GDNHVVVL-TRNKEVYSWGCGEYGRLGLDSEED---YYTPQKVDVPKAL----IIVAVQC 539
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGD-KSG--DAETLELIP---------KLQNKKC 361
G T L +G++ A G E+ +LGL SG + E +P +L K
Sbjct: 540 GCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKI 599
Query: 362 ISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGE-SEDLNEPTLAA-VDSRAPLRVSAGG 419
+IA G +++ A+ + G + ++G G+LG G + L L + + +RVS G
Sbjct: 600 RTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGD 659
Query: 420 QHTVLLVEE 428
+ T+ ++
Sbjct: 660 EFTIAATDD 668
Score = 58.8 bits (136), Expect = 4e-08
Identities = 57/226 (25%), Positives = 98/226 (43%), Gaps = 24/226 (10%)
Query: 178 PVKIDI---GEPAVEIASGGDHLVVLTTSGGVFTL-----GCGEQGQLGRLAQRSASRDA 229
P K+D+ G A ++ +G H V+T ++T G GQLG +++ R
Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGH-GDKASYRQP 417
Query: 230 RQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTA 289
+ +A +V G T V +L+AFG + YG +G+
Sbjct: 418 KH--------VEKLQGKAIRQVSCGDDFT-VCVTDEGQLYAFGSDYYGCMGVDKVAGPEV 468
Query: 290 LFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET 349
L P + + + + V+ G +H + L N ++Y+ G EYGRLGL D D T
Sbjct: 469 L-EPMQLNFFLS----NPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL-DSEEDYYT 522
Query: 350 LELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGE 395
+ + + +++ G +F +T SG+V + G+ KLG +
Sbjct: 523 PQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQ 568
Score = 45.6 bits (103), Expect = 4e-04
Identities = 35/126 (27%), Positives = 51/126 (40%), Gaps = 14/126 (11%)
Query: 44 GRVLTCGQGDVGQLGLGE------------DVVETTKFKYVTALGD-KIVDVQAGGMHTI 90
G+VL CG + +LGL + +V TT F L KI + G HT
Sbjct: 551 GKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTA 610
Query: 91 ALDSSGKIWTFGCNDEGALGRATSNEK-DEGTPKQXXXXXXXXXXXXGDSHSAALLQNGD 149
A+D G++ TFGCN G LG ++ GD + A +
Sbjct: 611 AIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNH 670
Query: 150 VYAWGS 155
++AWG+
Sbjct: 671 IFAWGN 676
Score = 40.3 bits (90), Expect = 0.016
Identities = 59/259 (22%), Positives = 98/259 (37%), Gaps = 30/259 (11%)
Query: 44 GRVLTCGQGDVGQLGL----GEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIW 99
G++ G G +G+ G +V+E + + L + + V G H + L + +++
Sbjct: 445 GQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFF--LSNPVEQVSCGDNHVVVLTRNKEVY 502
Query: 100 TFGCNDEGALGRATSNEKDEGTPKQXX--XXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
++GC + G LG +E+D TP++ G + L Q+G V A G
Sbjct: 503 SWGCGEYGRLG--LDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNE 560
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVE---------IASGGDHLVVLTTSGGVFT 208
+ + + G V + IA G H + G + T
Sbjct: 561 FNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLT 620
Query: 209 LGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATF-VLDAQHAR 267
GC + GQLG + R G + L P + RV G T D H
Sbjct: 621 FGCNKCGQLG-----VGNYKKRLGINLLGGPLG---GKQVIRVSCGDEFTIAATDDNH-- 670
Query: 268 LFAFGLNNYGQLGITGEKR 286
+FA+G G+L +T +R
Sbjct: 671 IFAWGNGGNGRLAMTPTER 689
Score = 33.9 bits (74), Expect = 1.4
Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWT 100
+RGR+LT G GQLG+G LG K ++ V G TIA I+
Sbjct: 614 ERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFA 673
Query: 101 FGCNDEGALGRATSNEKDEGT 121
+G G L T E+ G+
Sbjct: 674 WGNGGNGRLA-MTPTERPHGS 693
>BC093881-1|AAH93881.1| 979|Homo sapiens NIMA (never in mitosis
gene a)- related kinase 9 protein.
Length = 979
Score = 89.8 bits (213), Expect = 2e-17
Identities = 83/315 (26%), Positives = 143/315 (45%), Gaps = 35/315 (11%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGG 194
GD + + G +YA+GS D +G MG V G EP++++ + P +++ G
Sbjct: 434 GDDFTVCVTDEGQLYAFGS--DYYGCMG--VDKVAGPEVLEPMQLNFFLSNPVEQVSCGD 489
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQA--AARVW 252
+H+VVLT + V++ GCGE G+LG D+ + + P +V + +A V
Sbjct: 490 NHVVVLTRNKEVYSWGCGEYGRLG--------LDSEEDY---YTPQKVDVPKALIIVAVQ 538
Query: 253 AGHHATFVLDAQHARLFAFGLNNYGQLGI----TGEKRKTALFSP--TECDALRAVGDDH 306
G TF+L Q ++ A GLN + +LG+ +G A T L +
Sbjct: 539 CGCDGTFLL-TQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFY 597
Query: 307 AWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA 366
+A G+ HT + G++ G + G+LG+G+ L L K+ I ++
Sbjct: 598 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657
Query: 367 GTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL--------RVSAG 418
G + A TD +++WG G G+L +E + + R P+ +S
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPR-PIFGSLHHVPDLSCR 716
Query: 419 GQHTVLLVEETSSQR 433
G HT+L+VE+ + +
Sbjct: 717 GWHTILIVEKVLNSK 731
Score = 60.1 bits (139), Expect = 2e-08
Identities = 70/309 (22%), Positives = 134/309 (43%), Gaps = 34/309 (11%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDS---HGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASG 193
G++H A + ++Y W + + HG +G + +P K K+ G+ +++ G
Sbjct: 377 GNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQP-KHVEKLQ-GKAIRQVSCG 434
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
D V +T G ++ G G +G + A + + L +V
Sbjct: 435 DDFTVCVTDEGQLYAFGSDYYGCMG--VDKVAGPEVLEPMQL-----NFFLSNPVEQVSC 487
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
G + VL ++ ++++G YG+LG+ E+ ++P + D +A+ AV
Sbjct: 488 GDNHVVVL-TRNKEVYSWGCGEYGRLGLDSEED---YYTPQKVDVPKAL----IIVAVQC 539
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGD-KSG--DAETLELIP---------KLQNKKC 361
G T L +G++ A G E+ +LGL SG + E +P +L K
Sbjct: 540 GCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKI 599
Query: 362 ISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGE-SEDLNEPTLAA-VDSRAPLRVSAGG 419
+IA G +++ A+ + G + ++G G+LG G + L L + + +RVS G
Sbjct: 600 RTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGD 659
Query: 420 QHTVLLVEE 428
+ T+ ++
Sbjct: 660 EFTIAATDD 668
Score = 58.8 bits (136), Expect = 4e-08
Identities = 57/226 (25%), Positives = 98/226 (43%), Gaps = 24/226 (10%)
Query: 178 PVKIDI---GEPAVEIASGGDHLVVLTTSGGVFTL-----GCGEQGQLGRLAQRSASRDA 229
P K+D+ G A ++ +G H V+T ++T G GQLG +++ R
Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGH-GDKASYRQP 417
Query: 230 RQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTA 289
+ +A +V G T V +L+AFG + YG +G+
Sbjct: 418 KH--------VEKLQGKAIRQVSCGDDFT-VCVTDEGQLYAFGSDYYGCMGVDKVAGPEV 468
Query: 290 LFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET 349
L P + + + + V+ G +H + L N ++Y+ G EYGRLGL D D T
Sbjct: 469 L-EPMQLNFFLS----NPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL-DSEEDYYT 522
Query: 350 LELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGE 395
+ + + +++ G +F +T SG+V + G+ KLG +
Sbjct: 523 PQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQ 568
Score = 45.6 bits (103), Expect = 4e-04
Identities = 35/126 (27%), Positives = 51/126 (40%), Gaps = 14/126 (11%)
Query: 44 GRVLTCGQGDVGQLGLGE------------DVVETTKFKYVTALGD-KIVDVQAGGMHTI 90
G+VL CG + +LGL + +V TT F L KI + G HT
Sbjct: 551 GKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTA 610
Query: 91 ALDSSGKIWTFGCNDEGALGRATSNEK-DEGTPKQXXXXXXXXXXXXGDSHSAALLQNGD 149
A+D G++ TFGCN G LG ++ GD + A +
Sbjct: 611 AIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNH 670
Query: 150 VYAWGS 155
++AWG+
Sbjct: 671 IFAWGN 676
Score = 40.3 bits (90), Expect = 0.016
Identities = 59/259 (22%), Positives = 98/259 (37%), Gaps = 30/259 (11%)
Query: 44 GRVLTCGQGDVGQLGL----GEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIW 99
G++ G G +G+ G +V+E + + L + + V G H + L + +++
Sbjct: 445 GQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFF--LSNPVEQVSCGDNHVVVLTRNKEVY 502
Query: 100 TFGCNDEGALGRATSNEKDEGTPKQXX--XXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
++GC + G LG +E+D TP++ G + L Q+G V A G
Sbjct: 503 SWGCGEYGRLG--LDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNE 560
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVE---------IASGGDHLVVLTTSGGVFT 208
+ + + G V + IA G H + G + T
Sbjct: 561 FNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLT 620
Query: 209 LGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATF-VLDAQHAR 267
GC + GQLG + R G + L P + RV G T D H
Sbjct: 621 FGCNKCGQLG-----VGNYKKRLGINLLGGPLG---GKQVIRVSCGDEFTIAATDDNH-- 670
Query: 268 LFAFGLNNYGQLGITGEKR 286
+FA+G G+L +T +R
Sbjct: 671 IFAWGNGGNGRLAMTPTER 689
Score = 33.9 bits (74), Expect = 1.4
Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWT 100
+RGR+LT G GQLG+G LG K ++ V G TIA I+
Sbjct: 614 ERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFA 673
Query: 101 FGCNDEGALGRATSNEKDEGT 121
+G G L T E+ G+
Sbjct: 674 WGNGGNGRLA-MTPTERPHGS 693
>AY080896-1|AAL87410.1| 979|Homo sapiens NIMA-family kinase NERCC1
protein.
Length = 979
Score = 89.8 bits (213), Expect = 2e-17
Identities = 83/315 (26%), Positives = 143/315 (45%), Gaps = 35/315 (11%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGG 194
GD + + G +YA+GS D +G MG V G EP++++ + P +++ G
Sbjct: 434 GDDFTVCVTDEGQLYAFGS--DYYGCMG--VDKVAGPEVLEPMQLNFFLSNPVEQVSCGD 489
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQA--AARVW 252
+H+VVLT + V++ GCGE G+LG D+ + + P +V + +A V
Sbjct: 490 NHVVVLTRNKEVYSWGCGEYGRLG--------LDSEEDY---YTPQKVDVPKALIIVAVQ 538
Query: 253 AGHHATFVLDAQHARLFAFGLNNYGQLGI----TGEKRKTALFSP--TECDALRAVGDDH 306
G TF+L Q ++ A GLN + +LG+ +G A T L +
Sbjct: 539 CGCDGTFLL-TQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFY 597
Query: 307 AWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA 366
+A G+ HT + G++ G + G+LG+G+ L L K+ I ++
Sbjct: 598 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657
Query: 367 GTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL--------RVSAG 418
G + A TD +++WG G G+L +E + + R P+ +S
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPR-PIFGSLHHVPDLSCR 716
Query: 419 GQHTVLLVEETSSQR 433
G HT+L+VE+ + +
Sbjct: 717 GWHTILIVEKVLNSK 731
Score = 60.1 bits (139), Expect = 2e-08
Identities = 70/309 (22%), Positives = 134/309 (43%), Gaps = 34/309 (11%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDS---HGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASG 193
G++H A + ++Y W + + HG +G + +P K K+ G+ +++ G
Sbjct: 377 GNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQP-KHVEKLQ-GKAIHQVSCG 434
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
D V +T G ++ G G +G + A + + L +V
Sbjct: 435 DDFTVCVTDEGQLYAFGSDYYGCMG--VDKVAGPEVLEPMQL-----NFFLSNPVEQVSC 487
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
G + VL ++ ++++G YG+LG+ E+ ++P + D +A+ AV
Sbjct: 488 GDNHVVVL-TRNKEVYSWGCGEYGRLGLDSEED---YYTPQKVDVPKAL----IIVAVQC 539
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGD-KSG--DAETLELIP---------KLQNKKC 361
G T L +G++ A G E+ +LGL SG + E +P +L K
Sbjct: 540 GCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKI 599
Query: 362 ISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGE-SEDLNEPTLAA-VDSRAPLRVSAGG 419
+IA G +++ A+ + G + ++G G+LG G + L L + + +RVS G
Sbjct: 600 RTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGD 659
Query: 420 QHTVLLVEE 428
+ T+ ++
Sbjct: 660 EFTIAATDD 668
Score = 58.4 bits (135), Expect = 6e-08
Identities = 57/226 (25%), Positives = 98/226 (43%), Gaps = 24/226 (10%)
Query: 178 PVKIDI---GEPAVEIASGGDHLVVLTTSGGVFTL-----GCGEQGQLGRLAQRSASRDA 229
P K+D+ G A ++ +G H V+T ++T G GQLG +++ R
Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGH-GDKASYRQP 417
Query: 230 RQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTA 289
+ +A +V G T V +L+AFG + YG +G+
Sbjct: 418 KH--------VEKLQGKAIHQVSCGDDFT-VCVTDEGQLYAFGSDYYGCMGVDKVAGPEV 468
Query: 290 LFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET 349
L P + + + + V+ G +H + L N ++Y+ G EYGRLGL D D T
Sbjct: 469 L-EPMQLNFFLS----NPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL-DSEEDYYT 522
Query: 350 LELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGE 395
+ + + +++ G +F +T SG+V + G+ KLG +
Sbjct: 523 PQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQ 568
Score = 45.6 bits (103), Expect = 4e-04
Identities = 35/126 (27%), Positives = 51/126 (40%), Gaps = 14/126 (11%)
Query: 44 GRVLTCGQGDVGQLGLGE------------DVVETTKFKYVTALGD-KIVDVQAGGMHTI 90
G+VL CG + +LGL + +V TT F L KI + G HT
Sbjct: 551 GKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTA 610
Query: 91 ALDSSGKIWTFGCNDEGALGRATSNEK-DEGTPKQXXXXXXXXXXXXGDSHSAALLQNGD 149
A+D G++ TFGCN G LG ++ GD + A +
Sbjct: 611 AIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNH 670
Query: 150 VYAWGS 155
++AWG+
Sbjct: 671 IFAWGN 676
Score = 40.3 bits (90), Expect = 0.016
Identities = 59/259 (22%), Positives = 98/259 (37%), Gaps = 30/259 (11%)
Query: 44 GRVLTCGQGDVGQLGL----GEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIW 99
G++ G G +G+ G +V+E + + L + + V G H + L + +++
Sbjct: 445 GQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFF--LSNPVEQVSCGDNHVVVLTRNKEVY 502
Query: 100 TFGCNDEGALGRATSNEKDEGTPKQXX--XXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
++GC + G LG +E+D TP++ G + L Q+G V A G
Sbjct: 503 SWGCGEYGRLG--LDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNE 560
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVE---------IASGGDHLVVLTTSGGVFT 208
+ + + G V + IA G H + G + T
Sbjct: 561 FNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLT 620
Query: 209 LGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATF-VLDAQHAR 267
GC + GQLG + R G + L P + RV G T D H
Sbjct: 621 FGCNKCGQLG-----VGNYKKRLGINLLGGPLG---GKQVIRVSCGDEFTIAATDDNH-- 670
Query: 268 LFAFGLNNYGQLGITGEKR 286
+FA+G G+L +T +R
Sbjct: 671 IFAWGNGGNGRLAMTPTER 689
Score = 33.9 bits (74), Expect = 1.4
Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWT 100
+RGR+LT G GQLG+G LG K ++ V G TIA I+
Sbjct: 614 ERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFA 673
Query: 101 FGCNDEGALGRATSNEKDEGT 121
+G G L T E+ G+
Sbjct: 674 WGNGGNGRLA-MTPTERPHGS 693
>AY048580-1|AAL05428.1| 979|Homo sapiens NIMA-related kinase Nek8
protein.
Length = 979
Score = 89.8 bits (213), Expect = 2e-17
Identities = 83/315 (26%), Positives = 143/315 (45%), Gaps = 35/315 (11%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGG 194
GD + + G +YA+GS D +G MG V G EP++++ + P +++ G
Sbjct: 434 GDDFTVCVTDEGQLYAFGS--DYYGCMG--VDKVAGPEVLEPMQLNFFLSNPVEQVSCGD 489
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQA--AARVW 252
+H+VVLT + V++ GCGE G+LG D+ + + P +V + +A V
Sbjct: 490 NHVVVLTRNKEVYSWGCGEYGRLG--------LDSEEDY---YTPQKVDVPKALIIVAVQ 538
Query: 253 AGHHATFVLDAQHARLFAFGLNNYGQLGI----TGEKRKTALFSP--TECDALRAVGDDH 306
G TF+L Q ++ A GLN + +LG+ +G A T L +
Sbjct: 539 CGCDGTFLL-TQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFY 597
Query: 307 AWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA 366
+A G+ HT + G++ G + G+LG+G+ L L K+ I ++
Sbjct: 598 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657
Query: 367 GTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL--------RVSAG 418
G + A TD +++WG G G+L +E + + R P+ +S
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPR-PIFGSLHHVPDLSCR 716
Query: 419 GQHTVLLVEETSSQR 433
G HT+L+VE+ + +
Sbjct: 717 GWHTILIVEKVLNSK 731
Score = 60.1 bits (139), Expect = 2e-08
Identities = 70/309 (22%), Positives = 134/309 (43%), Gaps = 34/309 (11%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDS---HGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASG 193
G++H A + ++Y W + + HG +G + +P K K+ G+ +++ G
Sbjct: 377 GNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQP-KHVEKLQ-GKAIHQVSCG 434
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
D V +T G ++ G G +G + A + + L +V
Sbjct: 435 DDFTVCVTDEGQLYAFGSDYYGCMG--VDKVAGPEVLEPMQL-----NFFLSNPVEQVSC 487
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
G + VL ++ ++++G YG+LG+ E+ ++P + D +A+ AV
Sbjct: 488 GDNHVVVL-TRNKEVYSWGCGEYGRLGLDSEED---YYTPQKVDVPKAL----IIVAVQC 539
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGD-KSG--DAETLELIP---------KLQNKKC 361
G T L +G++ A G E+ +LGL SG + E +P +L K
Sbjct: 540 GCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKI 599
Query: 362 ISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGE-SEDLNEPTLAA-VDSRAPLRVSAGG 419
+IA G +++ A+ + G + ++G G+LG G + L L + + +RVS G
Sbjct: 600 RTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGD 659
Query: 420 QHTVLLVEE 428
+ T+ ++
Sbjct: 660 EFTIAATDD 668
Score = 58.4 bits (135), Expect = 6e-08
Identities = 57/226 (25%), Positives = 98/226 (43%), Gaps = 24/226 (10%)
Query: 178 PVKIDI---GEPAVEIASGGDHLVVLTTSGGVFTL-----GCGEQGQLGRLAQRSASRDA 229
P K+D+ G A ++ +G H V+T ++T G GQLG +++ R
Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGH-GDKASYRQP 417
Query: 230 RQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTA 289
+ +A +V G T V +L+AFG + YG +G+
Sbjct: 418 KH--------VEKLQGKAIHQVSCGDDFT-VCVTDEGQLYAFGSDYYGCMGVDKVAGPEV 468
Query: 290 LFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET 349
L P + + + + V+ G +H + L N ++Y+ G EYGRLGL D D T
Sbjct: 469 L-EPMQLNFFLS----NPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL-DSEEDYYT 522
Query: 350 LELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGE 395
+ + + +++ G +F +T SG+V + G+ KLG +
Sbjct: 523 PQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQ 568
Score = 45.6 bits (103), Expect = 4e-04
Identities = 35/126 (27%), Positives = 51/126 (40%), Gaps = 14/126 (11%)
Query: 44 GRVLTCGQGDVGQLGLGE------------DVVETTKFKYVTALGD-KIVDVQAGGMHTI 90
G+VL CG + +LGL + +V TT F L KI + G HT
Sbjct: 551 GKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTA 610
Query: 91 ALDSSGKIWTFGCNDEGALGRATSNEK-DEGTPKQXXXXXXXXXXXXGDSHSAALLQNGD 149
A+D G++ TFGCN G LG ++ GD + A +
Sbjct: 611 AIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNH 670
Query: 150 VYAWGS 155
++AWG+
Sbjct: 671 IFAWGN 676
Score = 40.3 bits (90), Expect = 0.016
Identities = 59/259 (22%), Positives = 98/259 (37%), Gaps = 30/259 (11%)
Query: 44 GRVLTCGQGDVGQLGL----GEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIW 99
G++ G G +G+ G +V+E + + L + + V G H + L + +++
Sbjct: 445 GQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFF--LSNPVEQVSCGDNHVVVLTRNKEVY 502
Query: 100 TFGCNDEGALGRATSNEKDEGTPKQXX--XXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
++GC + G LG +E+D TP++ G + L Q+G V A G
Sbjct: 503 SWGCGEYGRLG--LDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNE 560
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVE---------IASGGDHLVVLTTSGGVFT 208
+ + + G V + IA G H + G + T
Sbjct: 561 FNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLT 620
Query: 209 LGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATF-VLDAQHAR 267
GC + GQLG + R G + L P + RV G T D H
Sbjct: 621 FGCNKCGQLG-----VGNYKKRLGINLLGGPLG---GKQVIRVSCGDEFTIAATDDNH-- 670
Query: 268 LFAFGLNNYGQLGITGEKR 286
+FA+G G+L +T +R
Sbjct: 671 IFAWGNGGNGRLAMTPTER 689
Score = 33.9 bits (74), Expect = 1.4
Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWT 100
+RGR+LT G GQLG+G LG K ++ V G TIA I+
Sbjct: 614 ERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFA 673
Query: 101 FGCNDEGALGRATSNEKDEGT 121
+G G L T E+ G+
Sbjct: 674 WGNGGNGRLA-MTPTERPHGS 693
>AC007055-4|AAD31939.1| 414|Homo sapiens protein ( Homo sapiens
chromosome 14 clone BAC 201F1 map 14q24.3, complete
sequence. ).
Length = 414
Score = 89.8 bits (213), Expect = 2e-17
Identities = 83/315 (26%), Positives = 143/315 (45%), Gaps = 35/315 (11%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGG 194
GD + + G +YA+GS D +G MG V G EP++++ + P +++ G
Sbjct: 104 GDDFTVCVTDEGQLYAFGS--DYYGCMG--VDKVAGPEVLEPMQLNFFLSNPVEQVSCGD 159
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQA--AARVW 252
+H+VVLT + V++ GCGE G+LG D+ + + P +V + +A V
Sbjct: 160 NHVVVLTRNKEVYSWGCGEYGRLG--------LDSEEDY---YTPQKVDVPKALIIVAVQ 208
Query: 253 AGHHATFVLDAQHARLFAFGLNNYGQLGI----TGEKRKTALFSP--TECDALRAVGDDH 306
G TF+L Q ++ A GLN + +LG+ +G A T L +
Sbjct: 209 CGCDGTFLL-TQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFY 267
Query: 307 AWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA 366
+A G+ HT + G++ G + G+LG+G+ L L K+ I ++
Sbjct: 268 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 327
Query: 367 GTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL--------RVSAG 418
G + A TD +++WG G G+L +E + + R P+ +S
Sbjct: 328 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPR-PIFGSLHHVPDLSCR 386
Query: 419 GQHTVLLVEETSSQR 433
G HT+L+VE+ + +
Sbjct: 387 GWHTILIVEKVLNSK 401
Score = 60.1 bits (139), Expect = 2e-08
Identities = 70/309 (22%), Positives = 134/309 (43%), Gaps = 34/309 (11%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDS---HGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASG 193
G++H A + ++Y W + + HG +G + +P K K+ G+ +++ G
Sbjct: 47 GNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQP-KHVEKLQ-GKAIRQVSCG 104
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
D V +T G ++ G G +G + A + + L +V
Sbjct: 105 DDFTVCVTDEGQLYAFGSDYYGCMG--VDKVAGPEVLEPMQL-----NFFLSNPVEQVSC 157
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
G + VL ++ ++++G YG+LG+ E+ ++P + D +A+ AV
Sbjct: 158 GDNHVVVL-TRNKEVYSWGCGEYGRLGLDSEED---YYTPQKVDVPKAL----IIVAVQC 209
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGD-KSG--DAETLELIP---------KLQNKKC 361
G T L +G++ A G E+ +LGL SG + E +P +L K
Sbjct: 210 GCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKI 269
Query: 362 ISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGE-SEDLNEPTLAA-VDSRAPLRVSAGG 419
+IA G +++ A+ + G + ++G G+LG G + L L + + +RVS G
Sbjct: 270 RTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGD 329
Query: 420 QHTVLLVEE 428
+ T+ ++
Sbjct: 330 EFTIAATDD 338
Score = 58.8 bits (136), Expect = 4e-08
Identities = 57/226 (25%), Positives = 98/226 (43%), Gaps = 24/226 (10%)
Query: 178 PVKIDI---GEPAVEIASGGDHLVVLTTSGGVFTL-----GCGEQGQLGRLAQRSASRDA 229
P K+D+ G A ++ +G H V+T ++T G GQLG +++ R
Sbjct: 29 PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGH-GDKASYRQP 87
Query: 230 RQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTA 289
+ +A +V G T V +L+AFG + YG +G+
Sbjct: 88 KH--------VEKLQGKAIRQVSCGDDFT-VCVTDEGQLYAFGSDYYGCMGVDKVAGPEV 138
Query: 290 LFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET 349
L P + + + + V+ G +H + L N ++Y+ G EYGRLGL D D T
Sbjct: 139 L-EPMQLNFFLS----NPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL-DSEEDYYT 192
Query: 350 LELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGE 395
+ + + +++ G +F +T SG+V + G+ KLG +
Sbjct: 193 PQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQ 238
Score = 45.6 bits (103), Expect = 4e-04
Identities = 35/126 (27%), Positives = 51/126 (40%), Gaps = 14/126 (11%)
Query: 44 GRVLTCGQGDVGQLGLGE------------DVVETTKFKYVTALGD-KIVDVQAGGMHTI 90
G+VL CG + +LGL + +V TT F L KI + G HT
Sbjct: 221 GKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTA 280
Query: 91 ALDSSGKIWTFGCNDEGALGRATSNEK-DEGTPKQXXXXXXXXXXXXGDSHSAALLQNGD 149
A+D G++ TFGCN G LG ++ GD + A +
Sbjct: 281 AIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNH 340
Query: 150 VYAWGS 155
++AWG+
Sbjct: 341 IFAWGN 346
Score = 40.3 bits (90), Expect = 0.016
Identities = 59/259 (22%), Positives = 98/259 (37%), Gaps = 30/259 (11%)
Query: 44 GRVLTCGQGDVGQLGL----GEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIW 99
G++ G G +G+ G +V+E + + L + + V G H + L + +++
Sbjct: 115 GQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFF--LSNPVEQVSCGDNHVVVLTRNKEVY 172
Query: 100 TFGCNDEGALGRATSNEKDEGTPKQXX--XXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
++GC + G LG +E+D TP++ G + L Q+G V A G
Sbjct: 173 SWGCGEYGRLG--LDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNE 230
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVE---------IASGGDHLVVLTTSGGVFT 208
+ + + G V + IA G H + G + T
Sbjct: 231 FNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLT 290
Query: 209 LGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATF-VLDAQHAR 267
GC + GQLG + R G + L P + RV G T D H
Sbjct: 291 FGCNKCGQLG-----VGNYKKRLGINLLGGPLG---GKQVIRVSCGDEFTIAATDDNH-- 340
Query: 268 LFAFGLNNYGQLGITGEKR 286
+FA+G G+L +T +R
Sbjct: 341 IFAWGNGGNGRLAMTPTER 359
Score = 33.9 bits (74), Expect = 1.4
Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWT 100
+RGR+LT G GQLG+G LG K ++ V G TIA I+
Sbjct: 284 ERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFA 343
Query: 101 FGCNDEGALGRATSNEKDEGT 121
+G G L T E+ G+
Sbjct: 344 WGNGGNGRLA-MTPTERPHGS 363
>AB082526-1|BAC02704.1| 1011|Homo sapiens KIAA1995 protein protein.
Length = 1011
Score = 89.8 bits (213), Expect = 2e-17
Identities = 83/315 (26%), Positives = 143/315 (45%), Gaps = 35/315 (11%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGG 194
GD + + G +YA+GS D +G MG V G EP++++ + P +++ G
Sbjct: 466 GDDFTVCVTDEGQLYAFGS--DYYGCMG--VDKVAGPEVLEPMQLNFFLSNPVEQVSCGD 521
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQA--AARVW 252
+H+VVLT + V++ GCGE G+LG D+ + + P +V + +A V
Sbjct: 522 NHVVVLTRNKEVYSWGCGEYGRLG--------LDSEEDY---YTPQKVDVPKALIIVAVQ 570
Query: 253 AGHHATFVLDAQHARLFAFGLNNYGQLGI----TGEKRKTALFSP--TECDALRAVGDDH 306
G TF+L Q ++ A GLN + +LG+ +G A T L +
Sbjct: 571 CGCDGTFLL-TQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFY 629
Query: 307 AWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA 366
+A G+ HT + G++ G + G+LG+G+ L L K+ I ++
Sbjct: 630 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 689
Query: 367 GTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL--------RVSAG 418
G + A TD +++WG G G+L +E + + R P+ +S
Sbjct: 690 GDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPR-PIFGSLHHVPDLSCR 748
Query: 419 GQHTVLLVEETSSQR 433
G HT+L+VE+ + +
Sbjct: 749 GWHTILIVEKVLNSK 763
Score = 60.1 bits (139), Expect = 2e-08
Identities = 70/309 (22%), Positives = 134/309 (43%), Gaps = 34/309 (11%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDS---HGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASG 193
G++H A + ++Y W + + HG +G + +P K K+ G+ +++ G
Sbjct: 409 GNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQP-KHVEKLQ-GKAIHQVSCG 466
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
D V +T G ++ G G +G + A + + L +V
Sbjct: 467 DDFTVCVTDEGQLYAFGSDYYGCMG--VDKVAGPEVLEPMQL-----NFFLSNPVEQVSC 519
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
G + VL ++ ++++G YG+LG+ E+ ++P + D +A+ AV
Sbjct: 520 GDNHVVVL-TRNKEVYSWGCGEYGRLGLDSEED---YYTPQKVDVPKAL----IIVAVQC 571
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGD-KSG--DAETLELIP---------KLQNKKC 361
G T L +G++ A G E+ +LGL SG + E +P +L K
Sbjct: 572 GCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKI 631
Query: 362 ISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGE-SEDLNEPTLAA-VDSRAPLRVSAGG 419
+IA G +++ A+ + G + ++G G+LG G + L L + + +RVS G
Sbjct: 632 RTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGD 691
Query: 420 QHTVLLVEE 428
+ T+ ++
Sbjct: 692 EFTIAATDD 700
Score = 58.4 bits (135), Expect = 6e-08
Identities = 57/226 (25%), Positives = 98/226 (43%), Gaps = 24/226 (10%)
Query: 178 PVKIDI---GEPAVEIASGGDHLVVLTTSGGVFTL-----GCGEQGQLGRLAQRSASRDA 229
P K+D+ G A ++ +G H V+T ++T G GQLG +++ R
Sbjct: 391 PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGH-GDKASYRQP 449
Query: 230 RQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTA 289
+ +A +V G T V +L+AFG + YG +G+
Sbjct: 450 KH--------VEKLQGKAIHQVSCGDDFT-VCVTDEGQLYAFGSDYYGCMGVDKVAGPEV 500
Query: 290 LFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET 349
L P + + + + V+ G +H + L N ++Y+ G EYGRLGL D D T
Sbjct: 501 L-EPMQLNFFLS----NPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL-DSEEDYYT 554
Query: 350 LELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGE 395
+ + + +++ G +F +T SG+V + G+ KLG +
Sbjct: 555 PQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQ 600
Score = 45.6 bits (103), Expect = 4e-04
Identities = 35/126 (27%), Positives = 51/126 (40%), Gaps = 14/126 (11%)
Query: 44 GRVLTCGQGDVGQLGLGE------------DVVETTKFKYVTALGD-KIVDVQAGGMHTI 90
G+VL CG + +LGL + +V TT F L KI + G HT
Sbjct: 583 GKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTA 642
Query: 91 ALDSSGKIWTFGCNDEGALGRATSNEK-DEGTPKQXXXXXXXXXXXXGDSHSAALLQNGD 149
A+D G++ TFGCN G LG ++ GD + A +
Sbjct: 643 AIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNH 702
Query: 150 VYAWGS 155
++AWG+
Sbjct: 703 IFAWGN 708
Score = 40.3 bits (90), Expect = 0.016
Identities = 59/259 (22%), Positives = 98/259 (37%), Gaps = 30/259 (11%)
Query: 44 GRVLTCGQGDVGQLGL----GEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIW 99
G++ G G +G+ G +V+E + + L + + V G H + L + +++
Sbjct: 477 GQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFF--LSNPVEQVSCGDNHVVVLTRNKEVY 534
Query: 100 TFGCNDEGALGRATSNEKDEGTPKQXX--XXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
++GC + G LG +E+D TP++ G + L Q+G V A G
Sbjct: 535 SWGCGEYGRLG--LDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNE 592
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVE---------IASGGDHLVVLTTSGGVFT 208
+ + + G V + IA G H + G + T
Sbjct: 593 FNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLT 652
Query: 209 LGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATF-VLDAQHAR 267
GC + GQLG + R G + L P + RV G T D H
Sbjct: 653 FGCNKCGQLG-----VGNYKKRLGINLLGGPLG---GKQVIRVSCGDEFTIAATDDNH-- 702
Query: 268 LFAFGLNNYGQLGITGEKR 286
+FA+G G+L +T +R
Sbjct: 703 IFAWGNGGNGRLAMTPTER 721
Score = 33.9 bits (74), Expect = 1.4
Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWT 100
+RGR+LT G GQLG+G LG K ++ V G TIA I+
Sbjct: 646 ERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFA 705
Query: 101 FGCNDEGALGRATSNEKDEGT 121
+G G L T E+ G+
Sbjct: 706 WGNGGNGRLA-MTPTERPHGS 725
>BC029052-1|AAH29052.1| 551|Homo sapiens regulator of chromosome
condensation (RCC1) and BTB (POZ) domain containing pro
protein.
Length = 551
Score = 89.4 bits (212), Expect = 3e-17
Identities = 70/244 (28%), Positives = 114/244 (46%), Gaps = 19/244 (7%)
Query: 177 EPVKIDI--GEPAVEIASG-GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGF 233
EP ++D G+ ++ G G H+V+ TT G VFT G QLG + G
Sbjct: 88 EPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLG-------NGTTNHGL 140
Query: 234 SALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSP 293
+ ++ +Q V G + + VL + +FA+G NN GQ+G +
Sbjct: 141 VPCHISTNLSNKQVI-EVACGSYHSLVLTSD-GEVFAWGYNNSGQVGSGSTVNQPIPRRV 198
Query: 294 TECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELI 353
T C + V +A GQ + + G++Y G G+LGLG+ SG+ T +
Sbjct: 199 TGCLQNKVV------VTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGN-SGNQPTPCRV 251
Query: 354 PKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL 413
LQ + +A G +++ +TD G+VY+WG S G+LGTG + + PT V+ +
Sbjct: 252 AALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRII 311
Query: 414 RVSA 417
++A
Sbjct: 312 EIAA 315
Score = 85.0 bits (201), Expect = 6e-16
Identities = 75/257 (29%), Positives = 115/257 (44%), Gaps = 21/257 (8%)
Query: 175 CKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFS 234
C E ++ + A S G+ ++ T + +F LG G LG L ++ + R+ S
Sbjct: 37 CSEE-ELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLG-LGDVQSTIEPRRLDS 94
Query: 235 ALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPT 294
L ++ A +G H VL +F +G N Y QLG T
Sbjct: 95 --LNGKKI----ACLSYGSGPH--IVLATTEGEVFTWGHNAYSQLG-----NGTTNHGLV 141
Query: 295 ECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIP 354
C + + VA G +H+L L ++G+++A G G++G G +
Sbjct: 142 PCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTG 200
Query: 355 KLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT---LAAVDSRA 411
LQNK ++IA G AV D+GEVY WG G+LG G S N+PT +AA+
Sbjct: 201 CLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSG--NQPTPCRVAALQGIR 258
Query: 412 PLRVSAGGQHTVLLVEE 428
RV+ G HT++L +E
Sbjct: 259 VQRVACGYAHTLVLTDE 275
Score = 82.2 bits (194), Expect = 4e-15
Identities = 80/306 (26%), Positives = 115/306 (37%), Gaps = 28/306 (9%)
Query: 84 AGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDS-HSA 142
+ G + + +I+ G N G LG E G H
Sbjct: 53 SAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIV 112
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
G+V+ WG +++ +G PC + + +E+A G H +VLT+
Sbjct: 113 LATTEGEVFTWG--HNAYSQLGNGTTNHGLVPCHISTNLS-NKQVIEVACGSYHSLVLTS 169
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVT--LRQAAARVWAGHHATFV 260
G VF G GQ+G + Q +P RVT L+ A +
Sbjct: 170 DGEVFAWGYNNSGQVG------SGSTVNQP-----IPRRVTGCLQNKVVVTIACGQMCCM 218
Query: 261 LDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT 320
++ +G N GQLG+ + PT C G VA G HTL
Sbjct: 219 AVVDTGEVYVWGYNGNGQLGLGNSGNQ-----PTPCRVAALQGI--RVQRVACGYAHTLV 271
Query: 321 LAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA--GTSNSFAVTDSG 378
L GQ+YA G YG+LG G+KS + + ++ + I IAA T S A T G
Sbjct: 272 LTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVT--VEKDRIIEIAACHSTHTSAAKTQGG 329
Query: 379 EVYSWG 384
VY WG
Sbjct: 330 HVYMWG 335
Score = 66.9 bits (156), Expect = 2e-10
Identities = 77/293 (26%), Positives = 119/293 (40%), Gaps = 27/293 (9%)
Query: 46 VLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAG-GMHTIALDSSGKIWTFGC 103
+ G G LGLG DV T + + + +L G KI + G G H + + G+++T+G
Sbjct: 67 IFVLGTNCCGCLGLG-DVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGH 125
Query: 104 NDEGALGRATSNEKDEGTP-KQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
N LG T+N G HS L +G+V+AWG ++ G
Sbjct: 126 NAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWG--YNNSGQ 183
Query: 163 MGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQ 222
+G + P + + + V IA G + + +G V+ G GQLG
Sbjct: 184 VGSGSTVNQPIPRRVTGCLQ-NKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--LG 240
Query: 223 RSASRDARQGFSALLVPARVTLRQA--AARVWAGHHATFVLDAQHARLFAFGLNNYGQLG 280
S ++ P RV Q RV G+ T VL +++A+G N+YGQLG
Sbjct: 241 NSGNQP---------TPCRVAALQGIRVQRVACGYAHTLVL-TDEGQVYAWGANSYGQLG 290
Query: 281 ITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRC 333
TG K + +P + R + A H + G +Y G+C
Sbjct: 291 -TGNKSNQSYPTPVTVEKDRIIE-----IAACHSTHTSAAKTQGGHVYMWGQC 337
Score = 60.1 bits (139), Expect = 2e-08
Identities = 57/207 (27%), Positives = 89/207 (42%), Gaps = 14/207 (6%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWTFG 102
G V G + GQ+G G V + + L +K +V + G M +A+ +G+++ +G
Sbjct: 171 GEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230
Query: 103 CNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
N G LG S + G +H+ L G VYAWG+ +S+G
Sbjct: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGA--NSYGQ 288
Query: 163 MGLVVRGREGKPCKEPVKIDIGEPAVEIAS-GGDHLVVLTTSGG-VFTLG-C-GEQGQLG 218
+G + + P PV ++ + +EIA+ H T GG V+ G C G+ L
Sbjct: 289 LGTGNKSNQSYP--TPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILP 345
Query: 219 RLAQRSASRDARQGFSALLVPARVTLR 245
L S + D F+ PA VT R
Sbjct: 346 HLTHFSCTDDV---FACFATPA-VTWR 368
>AY341245-1|AAP88928.1| 551|Homo sapiens chromosome condensation
1-like protein.
Length = 551
Score = 89.4 bits (212), Expect = 3e-17
Identities = 70/244 (28%), Positives = 114/244 (46%), Gaps = 19/244 (7%)
Query: 177 EPVKIDI--GEPAVEIASG-GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGF 233
EP ++D G+ ++ G G H+V+ TT G VFT G QLG + G
Sbjct: 88 EPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLG-------NGTTNHGL 140
Query: 234 SALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSP 293
+ ++ +Q V G + + VL + +FA+G NN GQ+G +
Sbjct: 141 VPCHISTNLSNKQVI-EVACGSYHSLVLTSD-GEVFAWGYNNSGQVGSGSTVNQPIPRRV 198
Query: 294 TECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELI 353
T C + V +A GQ + + G++Y G G+LGLG+ SG+ T +
Sbjct: 199 TGCLQNKVV------VTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGN-SGNQPTPCRV 251
Query: 354 PKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL 413
LQ + +A G +++ +TD G+VY+WG S G+LGTG + + PT V+ +
Sbjct: 252 AALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRII 311
Query: 414 RVSA 417
++A
Sbjct: 312 EIAA 315
Score = 85.0 bits (201), Expect = 6e-16
Identities = 75/257 (29%), Positives = 115/257 (44%), Gaps = 21/257 (8%)
Query: 175 CKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFS 234
C E ++ + A S G+ ++ T + +F LG G LG L ++ + R+ S
Sbjct: 37 CSEE-ELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLG-LGDVQSTIEPRRLDS 94
Query: 235 ALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPT 294
L ++ A +G H VL +F +G N Y QLG T
Sbjct: 95 --LNGKKI----ACLSYGSGPH--IVLATTEGEVFTWGHNAYSQLG-----NGTTNHGLV 141
Query: 295 ECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIP 354
C + + VA G +H+L L ++G+++A G G++G G +
Sbjct: 142 PCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTG 200
Query: 355 KLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT---LAAVDSRA 411
LQNK ++IA G AV D+GEVY WG G+LG G S N+PT +AA+
Sbjct: 201 CLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSG--NQPTPCRVAALQGIR 258
Query: 412 PLRVSAGGQHTVLLVEE 428
RV+ G HT++L +E
Sbjct: 259 VQRVACGYAHTLVLTDE 275
Score = 82.2 bits (194), Expect = 4e-15
Identities = 80/306 (26%), Positives = 115/306 (37%), Gaps = 28/306 (9%)
Query: 84 AGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDS-HSA 142
+ G + + +I+ G N G LG E G H
Sbjct: 53 SAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIV 112
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
G+V+ WG +++ +G PC + + +E+A G H +VLT+
Sbjct: 113 LATTEGEVFTWG--HNAYSQLGNGTTNHGLVPCHISTNLS-NKQVIEVACGSYHSLVLTS 169
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVT--LRQAAARVWAGHHATFV 260
G VF G GQ+G + Q +P RVT L+ A +
Sbjct: 170 DGEVFAWGYNNSGQVG------SGSTVNQP-----IPRRVTGCLQNKVVVTIACGQMCCM 218
Query: 261 LDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT 320
++ +G N GQLG+ + PT C G VA G HTL
Sbjct: 219 AVVDTGEVYVWGYNGNGQLGLGNSGNQ-----PTPCRVAALQGI--RVQRVACGYAHTLV 271
Query: 321 LAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA--GTSNSFAVTDSG 378
L GQ+YA G YG+LG G+KS + + ++ + I IAA T S A T G
Sbjct: 272 LTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVT--VEKDRIIEIAACHSTHTSAAKTQGG 329
Query: 379 EVYSWG 384
VY WG
Sbjct: 330 HVYMWG 335
Score = 66.9 bits (156), Expect = 2e-10
Identities = 77/293 (26%), Positives = 119/293 (40%), Gaps = 27/293 (9%)
Query: 46 VLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAG-GMHTIALDSSGKIWTFGC 103
+ G G LGLG DV T + + + +L G KI + G G H + + G+++T+G
Sbjct: 67 IFVLGTNCCGCLGLG-DVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGH 125
Query: 104 NDEGALGRATSNEKDEGTP-KQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
N LG T+N G HS L +G+V+AWG ++ G
Sbjct: 126 NAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWG--YNNSGQ 183
Query: 163 MGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQ 222
+G + P + + + V IA G + + +G V+ G GQLG
Sbjct: 184 VGSGSTVNQPIPRRVTGCLQ-NKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--LG 240
Query: 223 RSASRDARQGFSALLVPARVTLRQA--AARVWAGHHATFVLDAQHARLFAFGLNNYGQLG 280
S ++ P RV Q RV G+ T VL +++A+G N+YGQLG
Sbjct: 241 NSGNQP---------TPCRVAALQGIRVQRVACGYAHTLVL-TDEGQVYAWGANSYGQLG 290
Query: 281 ITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRC 333
TG K + +P + R + A H + G +Y G+C
Sbjct: 291 -TGNKSNQSYPTPVTVEKDRIIE-----IAACHSTHTSAAKTQGGHVYMWGQC 337
Score = 60.1 bits (139), Expect = 2e-08
Identities = 57/207 (27%), Positives = 89/207 (42%), Gaps = 14/207 (6%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWTFG 102
G V G + GQ+G G V + + L +K +V + G M +A+ +G+++ +G
Sbjct: 171 GEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230
Query: 103 CNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
N G LG S + G +H+ L G VYAWG+ +S+G
Sbjct: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGA--NSYGQ 288
Query: 163 MGLVVRGREGKPCKEPVKIDIGEPAVEIAS-GGDHLVVLTTSGG-VFTLG-C-GEQGQLG 218
+G + + P PV ++ + +EIA+ H T GG V+ G C G+ L
Sbjct: 289 LGTGNKSNQSYP--TPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILP 345
Query: 219 RLAQRSASRDARQGFSALLVPARVTLR 245
L S + D F+ PA VT R
Sbjct: 346 HLTHFSCTDDV---FACFATPA-VTWR 368
>AL157813-1|CAH70795.1| 551|Homo sapiens regulator of chromosome
condensation (RCC1) and BTB (POZ) domain containing pro
protein.
Length = 551
Score = 89.4 bits (212), Expect = 3e-17
Identities = 70/244 (28%), Positives = 114/244 (46%), Gaps = 19/244 (7%)
Query: 177 EPVKIDI--GEPAVEIASG-GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGF 233
EP ++D G+ ++ G G H+V+ TT G VFT G QLG + G
Sbjct: 88 EPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLG-------NGTTNHGL 140
Query: 234 SALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSP 293
+ ++ +Q V G + + VL + +FA+G NN GQ+G +
Sbjct: 141 VPCHISTNLSNKQVI-EVACGSYHSLVLTSD-GEVFAWGYNNSGQVGSGSTVNQPIPRRV 198
Query: 294 TECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELI 353
T C + V +A GQ + + G++Y G G+LGLG+ SG+ T +
Sbjct: 199 TGCLQNKVV------VTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGN-SGNQPTPCRV 251
Query: 354 PKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL 413
LQ + +A G +++ +TD G+VY+WG S G+LGTG + + PT V+ +
Sbjct: 252 AALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRII 311
Query: 414 RVSA 417
++A
Sbjct: 312 EIAA 315
Score = 85.0 bits (201), Expect = 6e-16
Identities = 75/257 (29%), Positives = 115/257 (44%), Gaps = 21/257 (8%)
Query: 175 CKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFS 234
C E ++ + A S G+ ++ T + +F LG G LG L ++ + R+ S
Sbjct: 37 CSEE-ELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLG-LGDVQSTIEPRRLDS 94
Query: 235 ALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPT 294
L ++ A +G H VL +F +G N Y QLG T
Sbjct: 95 --LNGKKI----ACLSYGSGPH--IVLATTEGEVFTWGHNAYSQLG-----NGTTNHGLV 141
Query: 295 ECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIP 354
C + + VA G +H+L L ++G+++A G G++G G +
Sbjct: 142 PCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTG 200
Query: 355 KLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT---LAAVDSRA 411
LQNK ++IA G AV D+GEVY WG G+LG G S N+PT +AA+
Sbjct: 201 CLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSG--NQPTPCRVAALQGIR 258
Query: 412 PLRVSAGGQHTVLLVEE 428
RV+ G HT++L +E
Sbjct: 259 VQRVACGYAHTLVLTDE 275
Score = 82.2 bits (194), Expect = 4e-15
Identities = 80/306 (26%), Positives = 115/306 (37%), Gaps = 28/306 (9%)
Query: 84 AGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDS-HSA 142
+ G + + +I+ G N G LG E G H
Sbjct: 53 SAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIV 112
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
G+V+ WG +++ +G PC + + +E+A G H +VLT+
Sbjct: 113 LATTEGEVFTWG--HNAYSQLGNGTTNHGLVPCHISTNLS-NKQVIEVACGSYHSLVLTS 169
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVT--LRQAAARVWAGHHATFV 260
G VF G GQ+G + Q +P RVT L+ A +
Sbjct: 170 DGEVFAWGYNNSGQVG------SGSTVNQP-----IPRRVTGCLQNKVVVTIACGQMCCM 218
Query: 261 LDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT 320
++ +G N GQLG+ + PT C G VA G HTL
Sbjct: 219 AVVDTGEVYVWGYNGNGQLGLGNSGNQ-----PTPCRVAALQGI--RVQRVACGYAHTLV 271
Query: 321 LAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA--GTSNSFAVTDSG 378
L GQ+YA G YG+LG G+KS + + ++ + I IAA T S A T G
Sbjct: 272 LTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVT--VEKDRIIEIAACHSTHTSAAKTQGG 329
Query: 379 EVYSWG 384
VY WG
Sbjct: 330 HVYMWG 335
Score = 66.9 bits (156), Expect = 2e-10
Identities = 77/293 (26%), Positives = 119/293 (40%), Gaps = 27/293 (9%)
Query: 46 VLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAG-GMHTIALDSSGKIWTFGC 103
+ G G LGLG DV T + + + +L G KI + G G H + + G+++T+G
Sbjct: 67 IFVLGTNCCGCLGLG-DVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGH 125
Query: 104 NDEGALGRATSNEKDEGTP-KQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
N LG T+N G HS L +G+V+AWG ++ G
Sbjct: 126 NAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWG--YNNSGQ 183
Query: 163 MGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQ 222
+G + P + + + V IA G + + +G V+ G GQLG
Sbjct: 184 VGSGSTVNQPIPRRVTGCLQ-NKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--LG 240
Query: 223 RSASRDARQGFSALLVPARVTLRQA--AARVWAGHHATFVLDAQHARLFAFGLNNYGQLG 280
S ++ P RV Q RV G+ T VL +++A+G N+YGQLG
Sbjct: 241 NSGNQP---------TPCRVAALQGIRVQRVACGYAHTLVL-TDEGQVYAWGANSYGQLG 290
Query: 281 ITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRC 333
TG K + +P + R + A H + G +Y G+C
Sbjct: 291 -TGNKSNQSYPTPVTVEKDRIIE-----IAACHSTHTSAAKTQGGHVYMWGQC 337
Score = 60.1 bits (139), Expect = 2e-08
Identities = 57/207 (27%), Positives = 89/207 (42%), Gaps = 14/207 (6%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWTFG 102
G V G + GQ+G G V + + L +K +V + G M +A+ +G+++ +G
Sbjct: 171 GEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230
Query: 103 CNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
N G LG S + G +H+ L G VYAWG+ +S+G
Sbjct: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGA--NSYGQ 288
Query: 163 MGLVVRGREGKPCKEPVKIDIGEPAVEIAS-GGDHLVVLTTSGG-VFTLG-C-GEQGQLG 218
+G + + P PV ++ + +EIA+ H T GG V+ G C G+ L
Sbjct: 289 LGTGNKSNQSYP--TPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILP 345
Query: 219 RLAQRSASRDARQGFSALLVPARVTLR 245
L S + D F+ PA VT R
Sbjct: 346 HLTHFSCTDDV---FACFATPA-VTWR 368
>AF060219-1|AAC79987.1| 551|Homo sapiens RCC1-like G exchanging
factor RLG protein.
Length = 551
Score = 89.4 bits (212), Expect = 3e-17
Identities = 70/244 (28%), Positives = 114/244 (46%), Gaps = 19/244 (7%)
Query: 177 EPVKIDI--GEPAVEIASG-GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGF 233
EP ++D G+ ++ G G H+V+ TT G VFT G QLG + G
Sbjct: 88 EPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLG-------NGTTNHGL 140
Query: 234 SALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSP 293
+ ++ +Q V G + + VL + +FA+G NN GQ+G +
Sbjct: 141 VPCHISTNLSNKQVI-EVACGSYHSLVLTSD-GEVFAWGYNNSGQVGSGSTVNQPIPRRV 198
Query: 294 TECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELI 353
T C + V +A GQ + + G++Y G G+LGLG+ SG+ T +
Sbjct: 199 TGCLQNKVV------VTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGN-SGNQPTPCRV 251
Query: 354 PKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL 413
LQ + +A G +++ +TD G+VY+WG S G+LGTG + + PT V+ +
Sbjct: 252 AALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRII 311
Query: 414 RVSA 417
++A
Sbjct: 312 EIAA 315
Score = 85.0 bits (201), Expect = 6e-16
Identities = 75/257 (29%), Positives = 115/257 (44%), Gaps = 21/257 (8%)
Query: 175 CKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFS 234
C E ++ + A S G+ ++ T + +F LG G LG L ++ + R+ S
Sbjct: 37 CSEE-ELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLG-LGDVQSTIEPRRLDS 94
Query: 235 ALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPT 294
L ++ A +G H VL +F +G N Y QLG T
Sbjct: 95 --LNGKKI----ACLSYGSGPH--IVLATTEGEVFTWGHNAYSQLG-----NGTTNHGLV 141
Query: 295 ECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIP 354
C + + VA G +H+L L ++G+++A G G++G G +
Sbjct: 142 PCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTG 200
Query: 355 KLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT---LAAVDSRA 411
LQNK ++IA G AV D+GEVY WG G+LG G S N+PT +AA+
Sbjct: 201 CLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSG--NQPTPCRVAALQGIR 258
Query: 412 PLRVSAGGQHTVLLVEE 428
RV+ G HT++L +E
Sbjct: 259 VQRVACGYAHTLVLTDE 275
Score = 82.2 bits (194), Expect = 4e-15
Identities = 80/306 (26%), Positives = 115/306 (37%), Gaps = 28/306 (9%)
Query: 84 AGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDS-HSA 142
+ G + + +I+ G N G LG E G H
Sbjct: 53 SAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIV 112
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
G+V+ WG +++ +G PC + + +E+A G H +VLT+
Sbjct: 113 LATTEGEVFTWG--HNAYSQLGNGTTNHGLVPCHISTNLS-NKQVIEVACGSYHSLVLTS 169
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVT--LRQAAARVWAGHHATFV 260
G VF G GQ+G + Q +P RVT L+ A +
Sbjct: 170 DGEVFAWGYNNSGQVG------SGSTVNQP-----IPRRVTGCLQNKVVVTIACGQMCCM 218
Query: 261 LDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT 320
++ +G N GQLG+ + PT C G VA G HTL
Sbjct: 219 AVVDTGEVYVWGYNGNGQLGLGNSGNQ-----PTPCRVAALQGI--RVQRVACGYAHTLV 271
Query: 321 LAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA--GTSNSFAVTDSG 378
L GQ+YA G YG+LG G+KS + + ++ + I IAA T S A T G
Sbjct: 272 LTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVT--VEKDRIIEIAACHSTHTSAAKTQGG 329
Query: 379 EVYSWG 384
VY WG
Sbjct: 330 HVYMWG 335
Score = 66.9 bits (156), Expect = 2e-10
Identities = 77/293 (26%), Positives = 119/293 (40%), Gaps = 27/293 (9%)
Query: 46 VLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAG-GMHTIALDSSGKIWTFGC 103
+ G G LGLG DV T + + + +L G KI + G G H + + G+++T+G
Sbjct: 67 IFVLGTNCCGCLGLG-DVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGH 125
Query: 104 NDEGALGRATSNEKDEGTP-KQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
N LG T+N G HS L +G+V+AWG ++ G
Sbjct: 126 NAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWG--YNNSGQ 183
Query: 163 MGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQ 222
+G + P + + + V IA G + + +G V+ G GQLG
Sbjct: 184 VGSGSTVNQPIPRRVTGCLQ-NKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--LG 240
Query: 223 RSASRDARQGFSALLVPARVTLRQA--AARVWAGHHATFVLDAQHARLFAFGLNNYGQLG 280
S ++ P RV Q RV G+ T VL +++A+G N+YGQLG
Sbjct: 241 NSGNQP---------TPCRVAALQGIRVQRVACGYAHTLVL-TDEGQVYAWGANSYGQLG 290
Query: 281 ITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRC 333
TG K + +P + R + A H + G +Y G+C
Sbjct: 291 -TGNKSNQSYPTPVTVEKDRIIE-----IAACHSTHTSAAKTQGGHVYMWGQC 337
Score = 60.1 bits (139), Expect = 2e-08
Identities = 57/207 (27%), Positives = 89/207 (42%), Gaps = 14/207 (6%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWTFG 102
G V G + GQ+G G V + + L +K +V + G M +A+ +G+++ +G
Sbjct: 171 GEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230
Query: 103 CNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
N G LG S + G +H+ L G VYAWG+ +S+G
Sbjct: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGA--NSYGQ 288
Query: 163 MGLVVRGREGKPCKEPVKIDIGEPAVEIAS-GGDHLVVLTTSGG-VFTLG-C-GEQGQLG 218
+G + + P PV ++ + +EIA+ H T GG V+ G C G+ L
Sbjct: 289 LGTGNKSNQSYP--TPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILP 345
Query: 219 RLAQRSASRDARQGFSALLVPARVTLR 245
L S + D F+ PA VT R
Sbjct: 346 HLTHFSCTDDV---FACFATPA-VTWR 368
>AB209543-1|BAD92780.1| 556|Homo sapiens RCC1-like G exchanging
factor RLG variant protein.
Length = 556
Score = 89.4 bits (212), Expect = 3e-17
Identities = 70/244 (28%), Positives = 114/244 (46%), Gaps = 19/244 (7%)
Query: 177 EPVKIDI--GEPAVEIASG-GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGF 233
EP ++D G+ ++ G G H+V+ TT G VFT G QLG + G
Sbjct: 93 EPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLG-------NGTTNHGL 145
Query: 234 SALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSP 293
+ ++ +Q V G + + VL + +FA+G NN GQ+G +
Sbjct: 146 VPCHISTNLSNKQVI-EVACGSYHSLVLTSD-GEVFAWGYNNSGQVGSGSTVNQPIPRRV 203
Query: 294 TECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELI 353
T C + V +A GQ + + G++Y G G+LGLG+ SG+ T +
Sbjct: 204 TGCLQNKVV------VTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGN-SGNQPTPCRV 256
Query: 354 PKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL 413
LQ + +A G +++ +TD G+VY+WG S G+LGTG + + PT V+ +
Sbjct: 257 AALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRII 316
Query: 414 RVSA 417
++A
Sbjct: 317 EIAA 320
Score = 85.0 bits (201), Expect = 6e-16
Identities = 75/257 (29%), Positives = 115/257 (44%), Gaps = 21/257 (8%)
Query: 175 CKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFS 234
C E ++ + A S G+ ++ T + +F LG G LG L ++ + R+ S
Sbjct: 42 CSEE-ELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLG-LGDVQSTIEPRRLDS 99
Query: 235 ALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPT 294
L ++ A +G H VL +F +G N Y QLG T
Sbjct: 100 --LNGKKI----ACLSYGSGPH--IVLATTEGEVFTWGHNAYSQLG-----NGTTNHGLV 146
Query: 295 ECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIP 354
C + + VA G +H+L L ++G+++A G G++G G +
Sbjct: 147 PCHISTNLSNKQVIE-VACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTG 205
Query: 355 KLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT---LAAVDSRA 411
LQNK ++IA G AV D+GEVY WG G+LG G S N+PT +AA+
Sbjct: 206 CLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSG--NQPTPCRVAALQGIR 263
Query: 412 PLRVSAGGQHTVLLVEE 428
RV+ G HT++L +E
Sbjct: 264 VQRVACGYAHTLVLTDE 280
Score = 82.2 bits (194), Expect = 4e-15
Identities = 80/306 (26%), Positives = 115/306 (37%), Gaps = 28/306 (9%)
Query: 84 AGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDS-HSA 142
+ G + + +I+ G N G LG E G H
Sbjct: 58 SAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIV 117
Query: 143 ALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
G+V+ WG +++ +G PC + + +E+A G H +VLT+
Sbjct: 118 LATTEGEVFTWG--HNAYSQLGNGTTNHGLVPCHISTNLS-NKQVIEVACGSYHSLVLTS 174
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVT--LRQAAARVWAGHHATFV 260
G VF G GQ+G + Q +P RVT L+ A +
Sbjct: 175 DGEVFAWGYNNSGQVG------SGSTVNQP-----IPRRVTGCLQNKVVVTIACGQMCCM 223
Query: 261 LDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLT 320
++ +G N GQLG+ + PT C G VA G HTL
Sbjct: 224 AVVDTGEVYVWGYNGNGQLGLGNSGNQ-----PTPCRVAALQGI--RVQRVACGYAHTLV 276
Query: 321 LAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA--GTSNSFAVTDSG 378
L GQ+YA G YG+LG G+KS + + ++ + I IAA T S A T G
Sbjct: 277 LTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVT--VEKDRIIEIAACHSTHTSAAKTQGG 334
Query: 379 EVYSWG 384
VY WG
Sbjct: 335 HVYMWG 340
Score = 66.9 bits (156), Expect = 2e-10
Identities = 77/293 (26%), Positives = 119/293 (40%), Gaps = 27/293 (9%)
Query: 46 VLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAG-GMHTIALDSSGKIWTFGC 103
+ G G LGLG DV T + + + +L G KI + G G H + + G+++T+G
Sbjct: 72 IFVLGTNCCGCLGLG-DVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGH 130
Query: 104 NDEGALGRATSNEKDEGTP-KQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
N LG T+N G HS L +G+V+AWG ++ G
Sbjct: 131 NAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWG--YNNSGQ 188
Query: 163 MGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQ 222
+G + P + + + V IA G + + +G V+ G GQLG
Sbjct: 189 VGSGSTVNQPIPRRVTGCLQ-NKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLG--LG 245
Query: 223 RSASRDARQGFSALLVPARVTLRQA--AARVWAGHHATFVLDAQHARLFAFGLNNYGQLG 280
S ++ P RV Q RV G+ T VL +++A+G N+YGQLG
Sbjct: 246 NSGNQP---------TPCRVAALQGIRVQRVACGYAHTLVL-TDEGQVYAWGANSYGQLG 295
Query: 281 ITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRC 333
TG K + +P + R + A H + G +Y G+C
Sbjct: 296 -TGNKSNQSYPTPVTVEKDRIIE-----IAACHSTHTSAAKTQGGHVYMWGQC 342
Score = 60.1 bits (139), Expect = 2e-08
Identities = 57/207 (27%), Positives = 89/207 (42%), Gaps = 14/207 (6%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWTFG 102
G V G + GQ+G G V + + L +K +V + G M +A+ +G+++ +G
Sbjct: 176 GEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 235
Query: 103 CNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
N G LG S + G +H+ L G VYAWG+ +S+G
Sbjct: 236 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGA--NSYGQ 293
Query: 163 MGLVVRGREGKPCKEPVKIDIGEPAVEIAS-GGDHLVVLTTSGG-VFTLG-C-GEQGQLG 218
+G + + P PV ++ + +EIA+ H T GG V+ G C G+ L
Sbjct: 294 LGTGNKSNQSYP--TPVTVE-KDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILP 350
Query: 219 RLAQRSASRDARQGFSALLVPARVTLR 245
L S + D F+ PA VT R
Sbjct: 351 HLTHFSCTDDV---FACFATPA-VTWR 373
>BC038104-1|AAH38104.1| 355|Homo sapiens RCBTB1 protein protein.
Length = 355
Score = 87.0 bits (206), Expect = 1e-16
Identities = 60/224 (26%), Positives = 103/224 (45%), Gaps = 16/224 (7%)
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
G H+++ T G V+ G QLG + QG + + V + ++Q
Sbjct: 84 GPHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIATVQVCTNLLIKQVVEVACG 136
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
HH+ + A +FA+G NN GQ+G + T C ++ V +A
Sbjct: 137 SHHSMAL--AADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRV------VGIAC 188
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFA 373
GQ ++ + NG++Y G G+LGLG+ +G+ T + L + I G +++ A
Sbjct: 189 GQTSSMAVLDNGEVYGWGYNGNGQLGLGN-NGNQLTPVRVAALHSVCVNQIVCGYAHTLA 247
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSA 417
+TD G +Y+WG + G+LGTG +L P V+ + ++A
Sbjct: 248 LTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAA 291
Score = 85.8 bits (203), Expect = 3e-16
Identities = 52/170 (30%), Positives = 85/170 (50%), Gaps = 7/170 (4%)
Query: 260 VLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTL 319
+L + ++A+G N Y QLG + A ++ V + VA G HH++
Sbjct: 88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGIATVQVCTNLLIKQVVE------VACGSHHSM 141
Query: 320 TLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGE 379
LAA+G+++A G G++G G + ++ L K+ + IA G ++S AV D+GE
Sbjct: 142 ALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGE 201
Query: 380 VYSWGMGSEGKLGTGES-EDLNEPTLAAVDSRAPLRVSAGGQHTVLLVEE 428
VY WG G+LG G + L +AA+ S ++ G HT+ L +E
Sbjct: 202 VYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDE 251
Score = 70.1 bits (164), Expect = 2e-11
Identities = 76/294 (25%), Positives = 120/294 (40%), Gaps = 30/294 (10%)
Query: 97 KIWTFGCNDEGALGRATSNEKDEGTPKQXXXX---XXXXXXXXGDSHSAALLQNGDVYAW 153
+++ FG N LG T + + PK+ H ++G VYAW
Sbjct: 42 EVFVFGLNYSNCLG--TGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAW 99
Query: 154 GSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGE 213
G S G +G + I + VE+A G H + L G VF G
Sbjct: 100 GHNGYSQLGNGTTNQGIATVQVCTNLLI---KQVVEVACGSHHSMALAADGEVFAWGYNN 156
Query: 214 QGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATF-VLDAQHARLFAFG 272
GQ+G + +A++ + + L RV + G ++ VLD + ++ +G
Sbjct: 157 CGQVG--SGSTANQPTPRKVTNCLHIKRVV------GIACGQTSSMAVLD--NGEVYGWG 206
Query: 273 LNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGR 332
N GQLG+ + +P AL +V + + G HTL L G +YA G
Sbjct: 207 YNGNGQLGLGNNGNQ---LTPVRVAALHSV----CVNQIVCGYAHTLALTDEGLLYAWGA 259
Query: 333 CEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA--GTSNSFAVTDSGEVYSWG 384
YG+LG G+K+ ++ ++ ++ + IAA S A T G VY WG
Sbjct: 260 NTYGQLGTGNKNNLLSPAHIM--VEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
Score = 66.1 bits (154), Expect = 3e-10
Identities = 49/169 (28%), Positives = 85/169 (50%), Gaps = 11/169 (6%)
Query: 236 LLVPARV-TLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPT 294
LL P + ++R+ + A +V D + +F FGLN LG TG+ + T + P
Sbjct: 12 LLSPQEIASIRKVCVFGTSASEALYVTD--NDEVFVFGLNYSNCLG-TGDNQSTLV--PK 66
Query: 295 ECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIP 354
+ + L G + G H L+ +G +YA G Y +LG G + T+++
Sbjct: 67 KLEGL--CGKKIKSLSYGSGPHVLLS-TEDGVVYAWGHNGYSQLGNGTTNQGIATVQVCT 123
Query: 355 KLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT 403
L K+ + +A G+ +S A+ GEV++WG + G++G+G + N+PT
Sbjct: 124 NLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGST--ANQPT 170
Score = 60.9 bits (141), Expect = 1e-08
Identities = 72/281 (25%), Positives = 106/281 (37%), Gaps = 25/281 (8%)
Query: 57 LGLGEDVVETTKFKYVTALGDKIVDVQAG-GMHTIALDSSGKIWTFGCNDEGALGRATSN 115
LG G++ K G KI + G G H + G ++ +G N LG T+N
Sbjct: 54 LGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTN 113
Query: 116 EKDEGTPK-QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKP 174
+ G HS AL +G+V+AWG ++ G +G + P
Sbjct: 114 QGIATVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWG--YNNCGQVGSGSTANQPTP 171
Query: 175 CKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFS 234
K + I + V IA G + + +G V+ G GQLG + Q
Sbjct: 172 RKVTNCLHI-KRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLG------LGNNGNQ--- 221
Query: 235 ALLVPARVTLRQAAA--RVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFS 292
L P RV + ++ G+ T L L+A+G N YGQLG TG K L S
Sbjct: 222 --LTPVRVAALHSVCVNQIVCGYAHTLAL-TDEGLLYAWGANTYGQLG-TGNKNN--LLS 275
Query: 293 PTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRC 333
P + + A H + G +Y G+C
Sbjct: 276 PAH---IMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQC 313
Score = 49.2 bits (112), Expect = 3e-05
Identities = 37/116 (31%), Positives = 47/116 (40%), Gaps = 3/116 (2%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVD-VQAGGMHTIALDSSGKIWTFG 102
G V G GQLGLG + + T + V AL V+ + G HT+AL G ++ +G
Sbjct: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVR-VAALHSVCVNQIVCGYAHTLALTDEGLLYAWG 258
Query: 103 CNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSH-SAALLQNGDVYAWGSFR 157
N G LG N +H SAA Q G VY WG R
Sbjct: 259 ANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCR 314
>AL139321-5|CAH71047.1| 531|Homo sapiens regulator of chromosome
condensation (RCC1) and BTB (POZ) domain containing pro
protein.
Length = 531
Score = 86.6 bits (205), Expect = 2e-16
Identities = 60/224 (26%), Positives = 103/224 (45%), Gaps = 16/224 (7%)
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
G H+++ T G V+ G QLG + QG + + V + ++Q
Sbjct: 84 GPHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIAPVQVCTNLLIKQVVEVACG 136
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
HH+ + A +FA+G NN GQ+G + T C ++ V +A
Sbjct: 137 SHHSMAL--AADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRV------VGIAC 188
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFA 373
GQ ++ + NG++Y G G+LGLG+ +G+ T + L + I G +++ A
Sbjct: 189 GQTSSMAVLDNGEVYGWGYNGNGQLGLGN-NGNQLTPVRVAALHSVCVNQIVCGYAHTLA 247
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSA 417
+TD G +Y+WG + G+LGTG +L P V+ + ++A
Sbjct: 248 LTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAA 291
Score = 85.0 bits (201), Expect = 6e-16
Identities = 52/170 (30%), Positives = 85/170 (50%), Gaps = 7/170 (4%)
Query: 260 VLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTL 319
+L + ++A+G N Y QLG + A ++ V + VA G HH++
Sbjct: 88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVE------VACGSHHSM 141
Query: 320 TLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGE 379
LAA+G+++A G G++G G + ++ L K+ + IA G ++S AV D+GE
Sbjct: 142 ALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGE 201
Query: 380 VYSWGMGSEGKLGTGES-EDLNEPTLAAVDSRAPLRVSAGGQHTVLLVEE 428
VY WG G+LG G + L +AA+ S ++ G HT+ L +E
Sbjct: 202 VYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDE 251
Score = 73.3 bits (172), Expect = 2e-12
Identities = 75/294 (25%), Positives = 123/294 (41%), Gaps = 30/294 (10%)
Query: 97 KIWTFGCNDEGALGRATSNEKDEGTPKQXXXX---XXXXXXXXGDSHSAALLQNGDVYAW 153
+++ FG N LG T + + PK+ H ++G VYAW
Sbjct: 42 EVFVFGLNYSNCLG--TGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAW 99
Query: 154 GSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGE 213
G + + +G + P + + I + VE+A G H + L G VF G
Sbjct: 100 G--HNGYSQLGNGTTNQGIAPVQVCTNLLIKQ-VVEVACGSHHSMALAADGEVFAWGYNN 156
Query: 214 QGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATF-VLDAQHARLFAFG 272
GQ+G + +A++ + + L RV + G ++ VLD + ++ +G
Sbjct: 157 CGQVG--SGSTANQPTPRKVTNCLHIKRVV------GIACGQTSSMAVLD--NGEVYGWG 206
Query: 273 LNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGR 332
N GQLG+ + +P AL +V + + G HTL L G +YA G
Sbjct: 207 YNGNGQLGLGNNGNQ---LTPVRVAALHSV----CVNQIVCGYAHTLALTDEGLLYAWGA 259
Query: 333 CEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA--GTSNSFAVTDSGEVYSWG 384
YG+LG G+K+ ++ ++ ++ + IAA S A T G VY WG
Sbjct: 260 NTYGQLGTGNKNNLLSPAHIM--VEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
Score = 65.3 bits (152), Expect = 5e-10
Identities = 49/169 (28%), Positives = 85/169 (50%), Gaps = 11/169 (6%)
Query: 236 LLVPARV-TLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPT 294
LL P + ++R+A + A +V D + +F FGLN LG TG+ + T + P
Sbjct: 12 LLSPQEIASIRKACVFGTSASEALYVTD--NDEVFVFGLNYSNCLG-TGDNQSTLV--PK 66
Query: 295 ECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIP 354
+ + L G + G H L+ +G +YA G Y +LG G + +++
Sbjct: 67 KLEGL--CGKKIKSLSYGSGPHVLLS-TEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCT 123
Query: 355 KLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT 403
L K+ + +A G+ +S A+ GEV++WG + G++G+G + N+PT
Sbjct: 124 NLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGST--ANQPT 170
Score = 60.9 bits (141), Expect = 1e-08
Identities = 72/281 (25%), Positives = 106/281 (37%), Gaps = 25/281 (8%)
Query: 57 LGLGEDVVETTKFKYVTALGDKIVDVQAG-GMHTIALDSSGKIWTFGCNDEGALGRATSN 115
LG G++ K G KI + G G H + G ++ +G N LG T+N
Sbjct: 54 LGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTN 113
Query: 116 EKDEGTPK-QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKP 174
+ G HS AL +G+V+AWG ++ G +G + P
Sbjct: 114 QGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWG--YNNCGQVGSGSTANQPTP 171
Query: 175 CKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFS 234
K + I + V IA G + + +G V+ G GQLG + Q
Sbjct: 172 RKVTNCLHI-KRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLG------LGNNGNQ--- 221
Query: 235 ALLVPARVTLRQAAA--RVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFS 292
L P RV + ++ G+ T L L+A+G N YGQLG TG K L S
Sbjct: 222 --LTPVRVAALHSVCVNQIVCGYAHTLAL-TDEGLLYAWGANTYGQLG-TGNKNN--LLS 275
Query: 293 PTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRC 333
P + + A H + G +Y G+C
Sbjct: 276 PAH---IMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQC 313
Score = 49.2 bits (112), Expect = 3e-05
Identities = 37/116 (31%), Positives = 47/116 (40%), Gaps = 3/116 (2%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVD-VQAGGMHTIALDSSGKIWTFG 102
G V G GQLGLG + + T + V AL V+ + G HT+AL G ++ +G
Sbjct: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVR-VAALHSVCVNQIVCGYAHTLALTDEGLLYAWG 258
Query: 103 CNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSH-SAALLQNGDVYAWGSFR 157
N G LG N +H SAA Q G VY WG R
Sbjct: 259 ANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCR 314
>AK096654-1|BAC04833.1| 531|Homo sapiens protein ( Homo sapiens
cDNA FLJ39335 fis, clone OCBBF2017398, moderately
similar to Homo sapiens RCC1-like G exchanging factor
RLG mRNA. ).
Length = 531
Score = 86.6 bits (205), Expect = 2e-16
Identities = 60/224 (26%), Positives = 103/224 (45%), Gaps = 16/224 (7%)
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
G H+++ T G V+ G QLG + QG + + V + ++Q
Sbjct: 84 GPHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIAPVQVCTNLLIKQVVEVACG 136
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
HH+ + A +FA+G NN GQ+G + T C ++ V +A
Sbjct: 137 SHHSMAL--AADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRV------VGIAC 188
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFA 373
GQ ++ + NG++Y G G+LGLG+ +G+ T + L + I G +++ A
Sbjct: 189 GQTSSMAVLDNGEVYGWGYNGNGQLGLGN-NGNQLTPVRVAALHSVCVNQIVCGYAHTLA 247
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSA 417
+TD G +Y+WG + G+LGTG +L P V+ + ++A
Sbjct: 248 LTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAA 291
Score = 85.0 bits (201), Expect = 6e-16
Identities = 52/170 (30%), Positives = 85/170 (50%), Gaps = 7/170 (4%)
Query: 260 VLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTL 319
+L + ++A+G N Y QLG + A ++ V + VA G HH++
Sbjct: 88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVE------VACGSHHSM 141
Query: 320 TLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGE 379
LAA+G+++A G G++G G + ++ L K+ + IA G ++S AV D+GE
Sbjct: 142 ALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGE 201
Query: 380 VYSWGMGSEGKLGTGES-EDLNEPTLAAVDSRAPLRVSAGGQHTVLLVEE 428
VY WG G+LG G + L +AA+ S ++ G HT+ L +E
Sbjct: 202 VYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDE 251
Score = 73.3 bits (172), Expect = 2e-12
Identities = 75/294 (25%), Positives = 123/294 (41%), Gaps = 30/294 (10%)
Query: 97 KIWTFGCNDEGALGRATSNEKDEGTPKQXXXX---XXXXXXXXGDSHSAALLQNGDVYAW 153
+++ FG N LG T + + PK+ H ++G VYAW
Sbjct: 42 EVFVFGLNYSNCLG--TGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAW 99
Query: 154 GSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGE 213
G + + +G + P + + I + VE+A G H + L G VF G
Sbjct: 100 G--HNGYSQLGNGTTNQGIAPVQVCTNLLIKQ-VVEVACGSHHSMALAADGEVFAWGYNN 156
Query: 214 QGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATF-VLDAQHARLFAFG 272
GQ+G + +A++ + + L RV + G ++ VLD + ++ +G
Sbjct: 157 CGQVG--SGSTANQPTPRKVTNCLHIKRVV------GIACGQTSSMAVLD--NGEVYGWG 206
Query: 273 LNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGR 332
N GQLG+ + +P AL +V + + G HTL L G +YA G
Sbjct: 207 YNGNGQLGLGNNGNQ---LTPVRVAALHSV----CVNQIVCGYAHTLALTDEGLLYAWGA 259
Query: 333 CEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA--GTSNSFAVTDSGEVYSWG 384
YG+LG G+K+ ++ ++ ++ + IAA S A T G VY WG
Sbjct: 260 NTYGQLGTGNKNNLLSPAHIM--VEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
Score = 63.7 bits (148), Expect = 1e-09
Identities = 48/169 (28%), Positives = 84/169 (49%), Gaps = 11/169 (6%)
Query: 236 LLVPARV-TLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPT 294
LL P + ++R+ + A +V D + +F FGLN LG TG+ + T + P
Sbjct: 12 LLSPQEIASIRKVCVFGTSASEALYVTD--NDEVFVFGLNYSNCLG-TGDNQSTLV--PK 66
Query: 295 ECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIP 354
+ + L G + G H L+ +G +YA G Y +LG G + +++
Sbjct: 67 KLEGL--CGKKIKSLSYGSGPHVLLS-TEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCT 123
Query: 355 KLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT 403
L K+ + +A G+ +S A+ GEV++WG + G++G+G + N+PT
Sbjct: 124 NLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGST--ANQPT 170
Score = 60.9 bits (141), Expect = 1e-08
Identities = 72/281 (25%), Positives = 106/281 (37%), Gaps = 25/281 (8%)
Query: 57 LGLGEDVVETTKFKYVTALGDKIVDVQAG-GMHTIALDSSGKIWTFGCNDEGALGRATSN 115
LG G++ K G KI + G G H + G ++ +G N LG T+N
Sbjct: 54 LGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTN 113
Query: 116 EKDEGTPK-QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKP 174
+ G HS AL +G+V+AWG ++ G +G + P
Sbjct: 114 QGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWG--YNNCGQVGSGSTANQPTP 171
Query: 175 CKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFS 234
K + I + V IA G + + +G V+ G GQLG + Q
Sbjct: 172 RKVTNCLHI-KRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLG------LGNNGNQ--- 221
Query: 235 ALLVPARVTLRQAAA--RVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFS 292
L P RV + ++ G+ T L L+A+G N YGQLG TG K L S
Sbjct: 222 --LTPVRVAALHSVCVNQIVCGYAHTLAL-TDEGLLYAWGANTYGQLG-TGNKNN--LLS 275
Query: 293 PTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRC 333
P + + A H + G +Y G+C
Sbjct: 276 PAH---IMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQC 313
Score = 49.2 bits (112), Expect = 3e-05
Identities = 37/116 (31%), Positives = 47/116 (40%), Gaps = 3/116 (2%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVD-VQAGGMHTIALDSSGKIWTFG 102
G V G GQLGLG + + T + V AL V+ + G HT+AL G ++ +G
Sbjct: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVR-VAALHSVCVNQIVCGYAHTLALTDEGLLYAWG 258
Query: 103 CNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSH-SAALLQNGDVYAWGSFR 157
N G LG N +H SAA Q G VY WG R
Sbjct: 259 ANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCR 314
>AJ319660-1|CAC40027.1| 531|Homo sapiens guanine nucleotide
exchange factor protein.
Length = 531
Score = 86.6 bits (205), Expect = 2e-16
Identities = 60/224 (26%), Positives = 103/224 (45%), Gaps = 16/224 (7%)
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
G H+++ T G V+ G QLG + QG + + V + ++Q
Sbjct: 84 GPHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIAPVQVCTNLLIKQVVEVACG 136
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
HH+ + A +FA+G NN GQ+G + T C ++ V +A
Sbjct: 137 SHHSMAL--AADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRV------VGIAC 188
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFA 373
GQ ++ + NG++Y G G+LGLG+ +G+ T + L + I G +++ A
Sbjct: 189 GQTSSMAVLDNGEVYGWGYNGNGQLGLGN-NGNQLTPVRVAALHSVCVNQIVCGYAHTLA 247
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSA 417
+TD G +Y+WG + G+LGTG +L P V+ + ++A
Sbjct: 248 LTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAA 291
Score = 85.0 bits (201), Expect = 6e-16
Identities = 52/170 (30%), Positives = 85/170 (50%), Gaps = 7/170 (4%)
Query: 260 VLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTL 319
+L + ++A+G N Y QLG + A ++ V + VA G HH++
Sbjct: 88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVE------VACGSHHSM 141
Query: 320 TLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGE 379
LAA+G+++A G G++G G + ++ L K+ + IA G ++S AV D+GE
Sbjct: 142 ALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGE 201
Query: 380 VYSWGMGSEGKLGTGES-EDLNEPTLAAVDSRAPLRVSAGGQHTVLLVEE 428
VY WG G+LG G + L +AA+ S ++ G HT+ L +E
Sbjct: 202 VYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDE 251
Score = 73.3 bits (172), Expect = 2e-12
Identities = 75/294 (25%), Positives = 123/294 (41%), Gaps = 30/294 (10%)
Query: 97 KIWTFGCNDEGALGRATSNEKDEGTPKQXXXX---XXXXXXXXGDSHSAALLQNGDVYAW 153
+++ FG N LG T + + PK+ H ++G VYAW
Sbjct: 42 EVFVFGLNYSNCLG--TGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAW 99
Query: 154 GSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGE 213
G + + +G + P + + I + VE+A G H + L G VF G
Sbjct: 100 G--HNGYSQLGNGTTNQGIAPVQVCTNLLIKQ-VVEVACGSHHSMALAADGEVFAWGYNN 156
Query: 214 QGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATF-VLDAQHARLFAFG 272
GQ+G + +A++ + + L RV + G ++ VLD + ++ +G
Sbjct: 157 CGQVG--SGSTANQPTPRKVTNCLHIKRVV------GIACGQTSSMAVLD--NGEVYGWG 206
Query: 273 LNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGR 332
N GQLG+ + +P AL +V + + G HTL L G +YA G
Sbjct: 207 YNGNGQLGLGNNGNQ---LTPVRVAALHSV----CVNQIVCGYAHTLALTDEGLLYAWGA 259
Query: 333 CEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA--GTSNSFAVTDSGEVYSWG 384
YG+LG G+K+ ++ ++ ++ + IAA S A T G VY WG
Sbjct: 260 NTYGQLGTGNKNNLLSPAHIM--VEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
Score = 63.7 bits (148), Expect = 1e-09
Identities = 48/169 (28%), Positives = 84/169 (49%), Gaps = 11/169 (6%)
Query: 236 LLVPARV-TLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPT 294
LL P + ++R+ + A +V D + +F FGLN LG TG+ + T + P
Sbjct: 12 LLSPQEIASIRKVCVFGTSASEALYVTD--NDEVFVFGLNYSNCLG-TGDNQSTLV--PK 66
Query: 295 ECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIP 354
+ + L G + G H L+ +G +YA G Y +LG G + +++
Sbjct: 67 KLEGL--CGKKIKSLSYGSGPHVLLS-TEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCT 123
Query: 355 KLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT 403
L K+ + +A G+ +S A+ GEV++WG + G++G+G + N+PT
Sbjct: 124 NLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGST--ANQPT 170
Score = 60.9 bits (141), Expect = 1e-08
Identities = 72/281 (25%), Positives = 106/281 (37%), Gaps = 25/281 (8%)
Query: 57 LGLGEDVVETTKFKYVTALGDKIVDVQAG-GMHTIALDSSGKIWTFGCNDEGALGRATSN 115
LG G++ K G KI + G G H + G ++ +G N LG T+N
Sbjct: 54 LGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTN 113
Query: 116 EKDEGTPK-QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKP 174
+ G HS AL +G+V+AWG ++ G +G + P
Sbjct: 114 QGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWG--YNNCGQVGSGSTANQPTP 171
Query: 175 CKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFS 234
K + I + V IA G + + +G V+ G GQLG + Q
Sbjct: 172 RKVTNCLHI-KRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLG------LGNNGNQ--- 221
Query: 235 ALLVPARVTLRQAAA--RVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFS 292
L P RV + ++ G+ T L L+A+G N YGQLG TG K L S
Sbjct: 222 --LTPVRVAALHSVCVNQIVCGYAHTLAL-TDEGLLYAWGANTYGQLG-TGNKNN--LLS 275
Query: 293 PTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRC 333
P + + A H + G +Y G+C
Sbjct: 276 PAH---IMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQC 313
Score = 49.2 bits (112), Expect = 3e-05
Identities = 37/116 (31%), Positives = 47/116 (40%), Gaps = 3/116 (2%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVD-VQAGGMHTIALDSSGKIWTFG 102
G V G GQLGLG + + T + V AL V+ + G HT+AL G ++ +G
Sbjct: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVR-VAALHSVCVNQIVCGYAHTLALTDEGLLYAWG 258
Query: 103 CNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSH-SAALLQNGDVYAWGSFR 157
N G LG N +H SAA Q G VY WG R
Sbjct: 259 ANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCR 314
>AF334406-1|AAK38372.1| 531|Homo sapiens CLLL7 protein protein.
Length = 531
Score = 86.6 bits (205), Expect = 2e-16
Identities = 60/224 (26%), Positives = 103/224 (45%), Gaps = 16/224 (7%)
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
G H+++ T G V+ G QLG + QG + + V + ++Q
Sbjct: 84 GPHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIAPVQVCTNLLIKQVVEVACG 136
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
HH+ + A +FA+G NN GQ+G + T C ++ V +A
Sbjct: 137 SHHSMAL--AADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRV------VGIAC 188
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFA 373
GQ ++ + NG++Y G G+LGLG+ +G+ T + L + I G +++ A
Sbjct: 189 GQTSSMAVLDNGEVYGWGYNGNGQLGLGN-NGNQLTPVRVAALHSVCVNQIVCGYAHTLA 247
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSA 417
+TD G +Y+WG + G+LGTG +L P V+ + ++A
Sbjct: 248 LTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAA 291
Score = 85.0 bits (201), Expect = 6e-16
Identities = 52/170 (30%), Positives = 85/170 (50%), Gaps = 7/170 (4%)
Query: 260 VLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTL 319
+L + ++A+G N Y QLG + A ++ V + VA G HH++
Sbjct: 88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVE------VACGSHHSM 141
Query: 320 TLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGE 379
LAA+G+++A G G++G G + ++ L K+ + IA G ++S AV D+GE
Sbjct: 142 ALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGE 201
Query: 380 VYSWGMGSEGKLGTGES-EDLNEPTLAAVDSRAPLRVSAGGQHTVLLVEE 428
VY WG G+LG G + L +AA+ S ++ G HT+ L +E
Sbjct: 202 VYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDE 251
Score = 73.3 bits (172), Expect = 2e-12
Identities = 75/294 (25%), Positives = 123/294 (41%), Gaps = 30/294 (10%)
Query: 97 KIWTFGCNDEGALGRATSNEKDEGTPKQXXXX---XXXXXXXXGDSHSAALLQNGDVYAW 153
+++ FG N LG T + + PK+ H ++G VYAW
Sbjct: 42 EVFVFGLNYSNCLG--TGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAW 99
Query: 154 GSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGE 213
G + + +G + P + + I + VE+A G H + L G VF G
Sbjct: 100 G--HNGYSQLGNGTTNQGIAPVQVCTNLLIKQ-VVEVACGSHHSMALAADGEVFAWGYNN 156
Query: 214 QGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATF-VLDAQHARLFAFG 272
GQ+G + +A++ + + L RV + G ++ VLD + ++ +G
Sbjct: 157 CGQVG--SGSTANQPTPRKVTNCLHIKRVV------GIACGQTSSMAVLD--NGEVYGWG 206
Query: 273 LNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGR 332
N GQLG+ + +P AL +V + + G HTL L G +YA G
Sbjct: 207 YNGNGQLGLGNNGNQ---LTPVRVAALHSV----CVNQIVCGYAHTLALTDEGLLYAWGA 259
Query: 333 CEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA--GTSNSFAVTDSGEVYSWG 384
YG+LG G+K+ ++ ++ ++ + IAA S A T G VY WG
Sbjct: 260 NTYGQLGTGNKNNLLSPAHIM--VEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
Score = 63.7 bits (148), Expect = 1e-09
Identities = 48/169 (28%), Positives = 84/169 (49%), Gaps = 11/169 (6%)
Query: 236 LLVPARV-TLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPT 294
LL P + ++R+ + A +V D + +F FGLN LG TG+ + T + P
Sbjct: 12 LLSPQEIASIRKVCVFGTSASEALYVTD--NDEVFVFGLNYSNCLG-TGDNQSTLV--PK 66
Query: 295 ECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIP 354
+ + L G + G H L+ +G +YA G Y +LG G + +++
Sbjct: 67 KLEGL--CGKKIKSLSYGSGPHVLLS-TEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCT 123
Query: 355 KLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT 403
L K+ + +A G+ +S A+ GEV++WG + G++G+G + N+PT
Sbjct: 124 NLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGST--ANQPT 170
Score = 60.9 bits (141), Expect = 1e-08
Identities = 72/281 (25%), Positives = 106/281 (37%), Gaps = 25/281 (8%)
Query: 57 LGLGEDVVETTKFKYVTALGDKIVDVQAG-GMHTIALDSSGKIWTFGCNDEGALGRATSN 115
LG G++ K G KI + G G H + G ++ +G N LG T+N
Sbjct: 54 LGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTN 113
Query: 116 EKDEGTPK-QXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKP 174
+ G HS AL +G+V+AWG ++ G +G + P
Sbjct: 114 QGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWG--YNNCGQVGSGSTANQPTP 171
Query: 175 CKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFS 234
K + I + V IA G + + +G V+ G GQLG + Q
Sbjct: 172 RKVTNCLHI-KRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLG------LGNNGNQ--- 221
Query: 235 ALLVPARVTLRQAAA--RVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFS 292
L P RV + ++ G+ T L L+A+G N YGQLG TG K L S
Sbjct: 222 --LTPVRVAALHSVCVNQIVCGYAHTLAL-TDEGLLYAWGANTYGQLG-TGNKNN--LLS 275
Query: 293 PTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRC 333
P + + A H + G +Y G+C
Sbjct: 276 PAH---IMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQC 313
Score = 49.2 bits (112), Expect = 3e-05
Identities = 37/116 (31%), Positives = 47/116 (40%), Gaps = 3/116 (2%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVD-VQAGGMHTIALDSSGKIWTFG 102
G V G GQLGLG + + T + V AL V+ + G HT+AL G ++ +G
Sbjct: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVR-VAALHSVCVNQIVCGYAHTLALTDEGLLYAWG 258
Query: 103 CNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSH-SAALLQNGDVYAWGSFR 157
N G LG N +H SAA Q G VY WG R
Sbjct: 259 ANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCR 314
>AB027289-1|BAA88519.1| 1024|Homo sapiens cyclin-E binding protein 1
protein.
Length = 1024
Score = 86.6 bits (205), Expect = 2e-16
Identities = 61/182 (33%), Positives = 89/182 (48%), Gaps = 6/182 (3%)
Query: 39 APKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGK 97
A K G + GQ GQLG+G TT + V L G + + AG H++AL SG
Sbjct: 152 ALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGN 211
Query: 98 IWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
I+++G N+ G LG + KD+ + + G SHSA L Q+G ++ +G+
Sbjct: 212 IYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGA-- 269
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDH-LVVLTTSGGVFTLGCGEQGQ 216
HG +G E +PC V +G +IA G H L ++ G VF+ G G+ GQ
Sbjct: 270 GKHGQLGHNSTQNELRPCL--VAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQ 327
Query: 217 LG 218
LG
Sbjct: 328 LG 329
Score = 85.0 bits (201), Expect = 6e-16
Identities = 69/212 (32%), Positives = 101/212 (47%), Gaps = 20/212 (9%)
Query: 78 KIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXX 135
KI+ + G H++AL G+++ +G N G LG TP+ +
Sbjct: 139 KIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTT-TPQIVEHLAGVPLAQIS 197
Query: 136 XGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKID-IGEPAVE-IASG 193
G++HS AL +G++Y+WG ++ G +GL E K +P I+ + VE +A G
Sbjct: 198 AGEAHSMALSMSGNIYSWG--KNECGQLGL--GHTESKD--DPSLIEGLDNQKVEFVACG 251
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
G H +LT G +FT G G+ GQLG S + R A LV RVT Q A W
Sbjct: 252 GSHSALLTQDGLLFTFGAGKHGQLG---HNSTQNELRPCLVAELVGYRVT--QIACGRW- 305
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEK 285
H +V D ++F+FG GQLG G +
Sbjct: 306 -HTLAYVSDL--GKVFSFGSGKDGQLGNGGTR 334
Score = 83.8 bits (198), Expect = 1e-15
Identities = 39/119 (32%), Positives = 71/119 (59%), Gaps = 1/119 (0%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
+ G +H+L L+ G+++A G+ +G+LG+G K T +++ L I+AG ++
Sbjct: 143 ITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAH 202
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTL-AAVDSRAPLRVSAGGQHTVLLVEE 428
S A++ SG +YSWG G+LG G +E ++P+L +D++ V+ GG H+ LL ++
Sbjct: 203 SMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQD 261
Score = 74.9 bits (176), Expect = 6e-13
Identities = 52/180 (28%), Positives = 94/180 (52%), Gaps = 9/180 (5%)
Query: 250 RVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWS 309
++ G + + L ++ LFA+G N +GQLG+ G K + +P + L V +
Sbjct: 142 QITCGDYHSLAL-SKGGELFAWGQNLHGQLGV-GRKFPSTT-TPQIVEHLAGV----PLA 194
Query: 310 AVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTS 369
++ G+ H++ L+ +G IY+ G+ E G+LGLG + LI L N+K +A G S
Sbjct: 195 QISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDP-SLIEGLDNQKVEFVACGGS 253
Query: 370 NSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAA-VDSRAPLRVSAGGQHTVLLVEE 428
+S +T G ++++G G G+LG +++ P L A + +++ G HT+ V +
Sbjct: 254 HSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSD 313
Score = 70.9 bits (166), Expect = 1e-11
Identities = 63/231 (27%), Positives = 107/231 (46%), Gaps = 18/231 (7%)
Query: 188 VEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQA 247
++I G H + L+ G +F G GQLG + ++ S Q L A V L
Sbjct: 141 IQITCGDYHSLALSKGGELFAWGQNLHGQLG-VGRKFPSTTTPQIVEHL---AGVPL--- 193
Query: 248 AARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHA 307
A++ AG + L + ++++G N GQLG+ + K P+ + L D+
Sbjct: 194 -AQISAGEAHSMAL-SMSGNIYSWGKNECGQLGLGHTESKD---DPSLIEGL----DNQK 244
Query: 308 WSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAG 367
VA G H+ L +G ++ G ++G+LG + L+ +L + IA G
Sbjct: 245 VEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPC-LVAELVGYRVTQIACG 303
Query: 368 TSNSFA-VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSA 417
++ A V+D G+V+S+G G +G+LG G + D P V S L++ +
Sbjct: 304 RWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLES 354
Score = 46.8 bits (106), Expect = 2e-04
Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Query: 356 LQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGES-EDLNEPTLAAVDSRAPL- 413
LQ KK I I G +S A++ GE+++WG G+LG G P + + PL
Sbjct: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194
Query: 414 RVSAGGQHTVLL 425
++SAG H++ L
Sbjct: 195 QISAGEAHSMAL 206
Score = 39.9 bits (89), Expect = 0.021
Identities = 22/75 (29%), Positives = 35/75 (46%), Gaps = 1/75 (1%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSS-GKIWTFG 102
G + T G G GQLG E +G ++ + G HT+A S GK+++FG
Sbjct: 262 GLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFG 321
Query: 103 CNDEGALGRATSNEK 117
+G LG + ++
Sbjct: 322 SGKDGQLGNGGTRDQ 336
>AY337518-1|AAR00320.1| 1024|Homo sapiens HECT E3 ubiquitin ligase
protein.
Length = 1024
Score = 85.8 bits (203), Expect = 3e-16
Identities = 61/182 (33%), Positives = 88/182 (48%), Gaps = 6/182 (3%)
Query: 39 APKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGK 97
A K G + GQ GQLG+G TT + V L G + + AG H+ AL SG
Sbjct: 152 ALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSTALSMSGN 211
Query: 98 IWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
I+++G N+ G LG + KD+ + + G SHSA L Q+G ++ +G+
Sbjct: 212 IYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGA-- 269
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDH-LVVLTTSGGVFTLGCGEQGQ 216
HG +G E +PC V +G +IA G H L ++ G VF+ G G+ GQ
Sbjct: 270 GKHGQLGHNSTQNELRPCL--VAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQ 327
Query: 217 LG 218
LG
Sbjct: 328 LG 329
Score = 85.4 bits (202), Expect = 4e-16
Identities = 69/212 (32%), Positives = 101/212 (47%), Gaps = 20/212 (9%)
Query: 78 KIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXX 135
KI+ + G H++AL G+++ +G N G LG TP+ +
Sbjct: 139 KIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTT-TPQIVEHLAGVPLAQIS 197
Query: 136 XGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKID-IGEPAVE-IASG 193
G++HS AL +G++Y+WG ++ G +GL E K +P I+ + VE +A G
Sbjct: 198 AGEAHSTALSMSGNIYSWG--KNECGQLGL--GHTESKD--DPSLIEGLDNQKVEFVACG 251
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
G H +LT G +FT G G+ GQLG S + R A LV RVT Q A W
Sbjct: 252 GSHSALLTQDGLLFTFGAGKHGQLG---HNSTQNELRPCLVAELVGYRVT--QIACGRW- 305
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEK 285
H +V D ++F+FG GQLG G +
Sbjct: 306 -HTLAYVSDL--GKVFSFGSGKDGQLGNGGTR 334
Score = 83.0 bits (196), Expect = 2e-15
Identities = 39/119 (32%), Positives = 71/119 (59%), Gaps = 1/119 (0%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
+ G +H+L L+ G+++A G+ +G+LG+G K T +++ L I+AG ++
Sbjct: 143 ITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAH 202
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTL-AAVDSRAPLRVSAGGQHTVLLVEE 428
S A++ SG +YSWG G+LG G +E ++P+L +D++ V+ GG H+ LL ++
Sbjct: 203 STALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQD 261
Score = 73.7 bits (173), Expect = 1e-12
Identities = 52/180 (28%), Positives = 93/180 (51%), Gaps = 9/180 (5%)
Query: 250 RVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWS 309
++ G + + L ++ LFA+G N +GQLG+ G K + +P + L V +
Sbjct: 142 QITCGDYHSLAL-SKGGELFAWGQNLHGQLGV-GRKFPSTT-TPQIVEHLAGV----PLA 194
Query: 310 AVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTS 369
++ G+ H+ L+ +G IY+ G+ E G+LGLG + LI L N+K +A G S
Sbjct: 195 QISAGEAHSTALSMSGNIYSWGKNECGQLGLGHTESKDDP-SLIEGLDNQKVEFVACGGS 253
Query: 370 NSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAA-VDSRAPLRVSAGGQHTVLLVEE 428
+S +T G ++++G G G+LG +++ P L A + +++ G HT+ V +
Sbjct: 254 HSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSD 313
Score = 71.3 bits (167), Expect = 7e-12
Identities = 63/231 (27%), Positives = 107/231 (46%), Gaps = 18/231 (7%)
Query: 188 VEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQA 247
++I G H + L+ G +F G GQLG + ++ S Q L A V L Q
Sbjct: 141 IQITCGDYHSLALSKGGELFAWGQNLHGQLG-VGRKFPSTTTPQIVEHL---AGVPLAQI 196
Query: 248 AARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHA 307
+A H+T + + ++++G N GQLG+ + K P+ + L D+
Sbjct: 197 SA---GEAHSTAL--SMSGNIYSWGKNECGQLGLGHTESKD---DPSLIEGL----DNQK 244
Query: 308 WSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAG 367
VA G H+ L +G ++ G ++G+LG + L+ +L + IA G
Sbjct: 245 VEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPC-LVAELVGYRVTQIACG 303
Query: 368 TSNSFA-VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSA 417
++ A V+D G+V+S+G G +G+LG G + D P V S L++ +
Sbjct: 304 RWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLES 354
Score = 46.8 bits (106), Expect = 2e-04
Identities = 41/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 38 TAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGK 97
TA G + + G+ + GQLGLG + K+ V GG H+ L G
Sbjct: 204 TALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGL 263
Query: 98 IWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQN-GDVYAWGSF 156
++TFG G LG ++ + G H+ A + + G V+++GS
Sbjct: 264 LFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSG 323
Query: 157 RDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGG 205
+D G +G G + PVK+ E +++ S ++ +GG
Sbjct: 324 KD--GQLG--NGGTRDQLMPLPVKVSSSE-ELKLESHTSEKELIMIAGG 367
Score = 46.4 bits (105), Expect = 2e-04
Identities = 25/72 (34%), Positives = 37/72 (51%), Gaps = 2/72 (2%)
Query: 356 LQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGES-EDLNEPTLAAVDSRAPL- 413
LQ KK I I G +S A++ GE+++WG G+LG G P + + PL
Sbjct: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194
Query: 414 RVSAGGQHTVLL 425
++SAG H+ L
Sbjct: 195 QISAGEAHSTAL 206
>BC065375-1|AAH65375.1| 458|Homo sapiens secretion regulating
guanine nucleotide exchange factor protein.
Length = 458
Score = 84.2 bits (199), Expect = 1e-15
Identities = 105/400 (26%), Positives = 165/400 (41%), Gaps = 41/400 (10%)
Query: 50 GQGDVGQLGLG--EDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGCNDEG 107
G GQLGLG EDV+ + + + GG H+ + G ++ G N +G
Sbjct: 21 GANSYGQLGLGHKEDVLLPQQLNDFCK-PRSVRRITGGGGHSAVVTDGGDLFVCGLNKDG 79
Query: 108 ALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVV 167
LG + + TP + G + L +NG V + GS +S G +G V
Sbjct: 80 QLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS--NSFGQLG-VP 136
Query: 168 RGREGKPCKEPVKIDI-GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSAS 226
G + C P I++ E V IA+G H V T SG VF G G L +R
Sbjct: 137 HG--PRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTG----LASCGRRLCP 190
Query: 227 RDARQGFSALLVPARVT-LRQAAAR-VWAG-HHATFVLDAQHARLFAFGLNNYGQLGITG 283
F P+RVT L + A V AG H+ + DA ++ +G N +GQL
Sbjct: 191 GQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDA--GEVYVWGSNKHGQLA--- 245
Query: 284 EKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDK 343
A F P + +A+ G H + G+++ GR +YG+LG +
Sbjct: 246 ---NEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLE 302
Query: 344 SGDAETLE----LIP-------KLQNKKCIS----IAAGTSNSFAVTDSGEVYSWGMGSE 388
+ + LE +P + C++ ++ G+ ++ A+ G YSWG
Sbjct: 303 TYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVCYSWGWNEH 361
Query: 389 GKLGTGESEDLNEP-TLAAVDSRAPLRVSAGGQHTVLLVE 427
G G G ++ P + A+ S + L V G H++ L +
Sbjct: 362 GMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQ 401
Score = 73.7 bits (173), Expect = 1e-12
Identities = 78/312 (25%), Positives = 136/312 (43%), Gaps = 33/312 (10%)
Query: 91 ALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXX---XXXXXXXXGDSHSAALLQN 147
A ++ ++ +G N G LG +++D P+Q G HSA +
Sbjct: 10 AAPAAAALFAWGANSYGQLG--LGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDG 67
Query: 148 GDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVF 207
GD++ G +D G +GL E P P K G P ++A G D ++LT +G V
Sbjct: 68 GDLFVCGLNKD--GQLGL--GHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVL 123
Query: 208 TLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTL-RQAAARVWAG-HHATFVLDAQH 265
+ G GQLG G +VP + L ++ + AG HA +
Sbjct: 124 SCGSNSFGQLG----------VPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGI 173
Query: 266 ARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANG 325
+ GL + G+ G+ F+ E + + + A +A G H+ +L G
Sbjct: 174 VFQWGTGLASCGRRLCPGQTLPL-FFTAKEPSRVTGLENSKAMCVLA-GSDHSASLTDAG 231
Query: 326 QIYALGRCEYGRLGLGDKSGDAETLELIPKL-----QNKKCISIAAGTSNSFAVTDSGEV 380
++Y G ++G+L + +A L + K+ QN+K +I +G ++ A T++G++
Sbjct: 232 EVYVWGSNKHGQL-----ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKM 286
Query: 381 YSWGMGSEGKLG 392
++WG G+LG
Sbjct: 287 FTWGRADYGQLG 298
Score = 67.7 bits (158), Expect = 9e-11
Identities = 55/189 (29%), Positives = 79/189 (41%), Gaps = 18/189 (9%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+ G+VL+CG GQLG+ + + +K+V + AG H +A +SG ++ +
Sbjct: 118 ENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQW 177
Query: 102 G-----CNDEGALGRATSNEKDEGTPKQXXXXXXXXXX--XXGDSHSAALLQNGDVYAWG 154
G C G+ P + G HSA+L G+VY WG
Sbjct: 178 GTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWG 237
Query: 155 SFRDSHGSMGLVVRGREGKPCKEPVKIDI----GEPAVEIASGGDHLVVLTTSGGVFTLG 210
S + HG + E P KI+ E I SG HLV T +G +FT G
Sbjct: 238 S--NKHGQLA-----NEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWG 290
Query: 211 CGEQGQLGR 219
+ GQLGR
Sbjct: 291 RADYGQLGR 299
Score = 64.9 bits (151), Expect = 6e-10
Identities = 86/347 (24%), Positives = 133/347 (38%), Gaps = 31/347 (8%)
Query: 44 GRVLTCGQGDVGQLGLG--EDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
G + CG GQLGLG ED+ T K + G I V G TI L +G++ +
Sbjct: 68 GDLFVCGLNKDGQLGLGHTEDIPYFTPCK--SLFGCPIQQVACGWDFTIMLTENGQVLSC 125
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
G N G LG + G H+ A +G V+ WG+ S G
Sbjct: 126 GSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCG 185
Query: 162 SMGLVVRGREGK---PCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQ 216
+ G+ KEP ++ A+ + +G DH LT +G V+ G + GQ
Sbjct: 186 RR--LCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQ 243
Query: 217 LGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNY 276
LA +A Q + A + +W+G V + ++F +G +Y
Sbjct: 244 ---LANEAAFLPVPQ-----KIEAHCFQNEKVTAIWSG-WTHLVAQTETGKMFTWGRADY 294
Query: 277 GQLG-----ITGEK-RKTALFSPTECDALRAVGDDHAWSA---VALGQHHTLTLAANGQI 327
GQLG G K K F P H + V+ G H L + G
Sbjct: 295 GQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAI-IGGVC 353
Query: 328 YALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAV 374
Y+ G E+G G G ++ + + + L + + + G +S A+
Sbjct: 354 YSWGWNEHGMCGDGTEA-NVWAPKPVQALLSSSGLLVGCGAGHSLAL 399
Score = 52.4 bits (120), Expect = 4e-06
Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 1/106 (0%)
Query: 323 ANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYS 382
A ++A G YG+LGLG K +L + + I G +S VTD G+++
Sbjct: 13 AAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFV 72
Query: 383 WGMGSEGKLGTGESEDLNEPTLAAVDSRAPL-RVSAGGQHTVLLVE 427
G+ +G+LG G +ED+ T P+ +V+ G T++L E
Sbjct: 73 CGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTE 118
Score = 33.9 bits (74), Expect = 1.4
Identities = 18/61 (29%), Positives = 31/61 (50%), Gaps = 2/61 (3%)
Query: 369 SNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLA--AVDSRAPLRVSAGGQHTVLLV 426
S S A + +++WG S G+LG G ED+ P R+ R++ GG H+ ++
Sbjct: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVT 65
Query: 427 E 427
+
Sbjct: 66 D 66
>AJ243950-1|CAB60832.1| 458|Homo sapiens deafness locus associated
putative guanine nucleotide exchange factor protein.
Length = 458
Score = 84.2 bits (199), Expect = 1e-15
Identities = 105/400 (26%), Positives = 165/400 (41%), Gaps = 41/400 (10%)
Query: 50 GQGDVGQLGLG--EDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGCNDEG 107
G GQLGLG EDV+ + + + GG H+ + G ++ G N +G
Sbjct: 21 GANSYGQLGLGHKEDVLLPQQLNDFCK-PRSVRRITGGGGHSAVVTDGGDLFVCGLNKDG 79
Query: 108 ALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVV 167
LG + + TP + G + L +NG V + GS +S G +G V
Sbjct: 80 QLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS--NSFGQLG-VP 136
Query: 168 RGREGKPCKEPVKIDI-GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSAS 226
G + C P I++ E V IA+G H V T SG VF G G L +R
Sbjct: 137 HG--PRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTG----LASCGRRLCP 190
Query: 227 RDARQGFSALLVPARVT-LRQAAAR-VWAG-HHATFVLDAQHARLFAFGLNNYGQLGITG 283
F P+RVT L + A V AG H+ + DA ++ +G N +GQL
Sbjct: 191 GQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDA--GEVYVWGSNKHGQLA--- 245
Query: 284 EKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDK 343
A F P + +A+ G H + G+++ GR +YG+LG +
Sbjct: 246 ---NEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLE 302
Query: 344 SGDAETLE----LIP-------KLQNKKCIS----IAAGTSNSFAVTDSGEVYSWGMGSE 388
+ + LE +P + C++ ++ G+ ++ A+ G YSWG
Sbjct: 303 TYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVCYSWGWNEH 361
Query: 389 GKLGTGESEDLNEP-TLAAVDSRAPLRVSAGGQHTVLLVE 427
G G G ++ P + A+ S + L V G H++ L +
Sbjct: 362 GMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQ 401
Score = 73.7 bits (173), Expect = 1e-12
Identities = 78/312 (25%), Positives = 136/312 (43%), Gaps = 33/312 (10%)
Query: 91 ALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXX---XXXXXXXXGDSHSAALLQN 147
A ++ ++ +G N G LG +++D P+Q G HSA +
Sbjct: 10 AAPAAAALFAWGANSYGQLG--LGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDG 67
Query: 148 GDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVF 207
GD++ G +D G +GL E P P K G P ++A G D ++LT +G V
Sbjct: 68 GDLFVCGLNKD--GQLGL--GHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVL 123
Query: 208 TLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTL-RQAAARVWAG-HHATFVLDAQH 265
+ G GQLG G +VP + L ++ + AG HA +
Sbjct: 124 SCGSNSFGQLG----------VPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGI 173
Query: 266 ARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANG 325
+ GL + G+ G+ F+ E + + + A +A G H+ +L G
Sbjct: 174 VFQWGTGLASCGRRLCPGQTLPL-FFTAKEPSRVTGLENSKAMCVLA-GSDHSASLTDAG 231
Query: 326 QIYALGRCEYGRLGLGDKSGDAETLELIPKL-----QNKKCISIAAGTSNSFAVTDSGEV 380
++Y G ++G+L + +A L + K+ QN+K +I +G ++ A T++G++
Sbjct: 232 EVYVWGSNKHGQL-----ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKM 286
Query: 381 YSWGMGSEGKLG 392
++WG G+LG
Sbjct: 287 FTWGRADYGQLG 298
Score = 67.7 bits (158), Expect = 9e-11
Identities = 55/189 (29%), Positives = 79/189 (41%), Gaps = 18/189 (9%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+ G+VL+CG GQLG+ + + +K+V + AG H +A +SG ++ +
Sbjct: 118 ENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQW 177
Query: 102 G-----CNDEGALGRATSNEKDEGTPKQXXXXXXXXXX--XXGDSHSAALLQNGDVYAWG 154
G C G+ P + G HSA+L G+VY WG
Sbjct: 178 GTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWG 237
Query: 155 SFRDSHGSMGLVVRGREGKPCKEPVKIDI----GEPAVEIASGGDHLVVLTTSGGVFTLG 210
S + HG + E P KI+ E I SG HLV T +G +FT G
Sbjct: 238 S--NKHGQLA-----NEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWG 290
Query: 211 CGEQGQLGR 219
+ GQLGR
Sbjct: 291 RADYGQLGR 299
Score = 64.9 bits (151), Expect = 6e-10
Identities = 86/347 (24%), Positives = 133/347 (38%), Gaps = 31/347 (8%)
Query: 44 GRVLTCGQGDVGQLGLG--EDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
G + CG GQLGLG ED+ T K + G I V G TI L +G++ +
Sbjct: 68 GDLFVCGLNKDGQLGLGHTEDIPYFTPCK--SLFGCPIQQVACGWDFTIMLTENGQVLSC 125
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
G N G LG + G H+ A +G V+ WG+ S G
Sbjct: 126 GSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCG 185
Query: 162 SMGLVVRGREGK---PCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQ 216
+ G+ KEP ++ A+ + +G DH LT +G V+ G + GQ
Sbjct: 186 RR--LCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQ 243
Query: 217 LGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNY 276
LA +A Q + A + +W+G V + ++F +G +Y
Sbjct: 244 ---LANEAAFLPVPQ-----KIEAHCFQNEKVTAIWSG-WTHLVAQTETGKMFTWGRADY 294
Query: 277 GQLG-----ITGEK-RKTALFSPTECDALRAVGDDHAWSA---VALGQHHTLTLAANGQI 327
GQLG G K K F P H + V+ G H L + G
Sbjct: 295 GQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAI-IGGVC 353
Query: 328 YALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAV 374
Y+ G E+G G G ++ + + + L + + + G +S A+
Sbjct: 354 YSWGWNEHGMCGDGTEA-NVWAPKPVQALLSSSGLLVGCGAGHSLAL 399
Score = 52.4 bits (120), Expect = 4e-06
Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 1/106 (0%)
Query: 323 ANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYS 382
A ++A G YG+LGLG K +L + + I G +S VTD G+++
Sbjct: 13 AAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFV 72
Query: 383 WGMGSEGKLGTGESEDLNEPTLAAVDSRAPL-RVSAGGQHTVLLVE 427
G+ +G+LG G +ED+ T P+ +V+ G T++L E
Sbjct: 73 CGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTE 118
Score = 33.9 bits (74), Expect = 1.4
Identities = 18/61 (29%), Positives = 31/61 (50%), Gaps = 2/61 (3%)
Query: 369 SNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLA--AVDSRAPLRVSAGGQHTVLLV 426
S S A + +++WG S G+LG G ED+ P R+ R++ GG H+ ++
Sbjct: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVT 65
Query: 427 E 427
+
Sbjct: 66 D 66
>BC113705-1|AAI13706.1| 692|Homo sapiens NIMA (never in mitosis
gene a)- related kinase 8 protein.
Length = 692
Score = 83.8 bits (198), Expect = 1e-15
Identities = 86/312 (27%), Positives = 134/312 (42%), Gaps = 30/312 (9%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGG 194
GD +A L G + +GS GS G + G +P ++ +G V++A G
Sbjct: 399 GDFFTACLTDRGIIMTFGS-----GSNGCLGHGSL-TDISQPTIVEALLGYEMVQVACGA 452
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAG 254
H++ L+T +F G G+ G+LG L R + +Q VP + Q A RV G
Sbjct: 453 SHVLALSTERELFAWGRGDSGRLG-LGTRESHSCPQQ------VP--MPPGQEAQRVVCG 503
Query: 255 HHATFVLDAQHARLFAFGLNNYGQLGIT----GEKRKTALFSPTECDALRAVG----DDH 306
++ +L L A G N + +LG+ GE+ E + +G D
Sbjct: 504 IDSSMILTVPGQAL-ACGSNRFNKLGLDHLSLGEE-PVPHQQVEEALSFTLLGSAPLDQE 561
Query: 307 AWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA 366
++ LG H+ + A+G Y G ++G+LG + G + + L+ K +A
Sbjct: 562 PLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCK-VQGLEGIKMAMVAC 620
Query: 367 GTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRV-SAGGQHTVLL 425
G + + A+ EVYSWG G+ G+LG ED P +D P V S H L
Sbjct: 621 GDAFTVAIGAESEVYSWGKGARGRLGR-RDEDAGLPRPVQLDETHPYTVTSVSCCHGNTL 679
Query: 426 VEETSSQREPSP 437
+ S EP P
Sbjct: 680 LAVRSVTDEPVP 691
Score = 57.2 bits (132), Expect = 1e-07
Identities = 56/208 (26%), Positives = 86/208 (41%), Gaps = 17/208 (8%)
Query: 43 RGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTF 101
RG ++T G G G LG G + + ++ V AL G ++V V G H +AL + +++ +
Sbjct: 409 RGIIMTFGSGSNGCLGHGS-LTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAW 467
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXX--XXXXXXXXXGDSHSAALLQNGDVYAWGSFRDS 159
G D G LG T + P+Q G S L G A GS R +
Sbjct: 468 GRGDSGRLGLGT--RESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFN 525
Query: 160 HGSMGLVVRGREGKP---CKEPVKIDI-------GEPAVEIASGGDHLVVLTTSGGVFTL 209
+ + G E P +E + + EP + I G H +T SG +T
Sbjct: 526 KLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTF 585
Query: 210 GCGEQGQLGRLAQRSASRDAR-QGFSAL 236
G + GQLG +R + + QG +
Sbjct: 586 GSNQHGQLGTNTRRGSRAPCKVQGLEGI 613
Score = 50.8 bits (116), Expect = 1e-05
Identities = 42/157 (26%), Positives = 64/157 (40%), Gaps = 19/157 (12%)
Query: 44 GRVLTCGQGDVGQLGL-----GEDVVETTKFKYV---TALG------DKIVDVQAGGMHT 89
G+ L CG +LGL GE+ V + + T LG + ++ + G H+
Sbjct: 514 GQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHS 573
Query: 90 IALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGD 149
A+ +SG +TFG N G LG T Q GD+ + A+ +
Sbjct: 574 AAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESE 633
Query: 150 VYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEP 186
VY+WG G+ G + R E PV++D P
Sbjct: 634 VYSWGK-----GARGRLGRRDEDAGLPRPVQLDETHP 665
Score = 48.4 bits (110), Expect = 6e-05
Identities = 28/92 (30%), Positives = 42/92 (45%), Gaps = 1/92 (1%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
VA G T L G I G G LG G + D ++ L + + +A G S+
Sbjct: 396 VACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLT-DISQPTIVEALLGYEMVQVACGASH 454
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNEP 402
A++ E+++WG G G+LG G E + P
Sbjct: 455 VLALSTERELFAWGRGDSGRLGLGTRESHSCP 486
Score = 47.6 bits (108), Expect = 1e-04
Identities = 63/254 (24%), Positives = 95/254 (37%), Gaps = 31/254 (12%)
Query: 190 IASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAA 249
+A G LT G + T G G G LG + S+ +V A +
Sbjct: 396 VACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPT-------IVEALLGYEMVQV 448
Query: 250 RVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWS 309
A H L + LFA+G + G+LG+ G + + C +
Sbjct: 449 ACGASH--VLALSTER-ELFAWGRGDSGRLGL-GTRESHS------CPQQVPMPPGQEAQ 498
Query: 310 AVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAE-------------TLELIPKL 356
V G ++ L GQ A G + +LGL S E TL L
Sbjct: 499 RVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPL 558
Query: 357 QNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEP-TLAAVDSRAPLRV 415
+ +SI GT++S AVT SG+ Y++G G+LGT P + ++ V
Sbjct: 559 DQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMV 618
Query: 416 SAGGQHTVLLVEET 429
+ G TV + E+
Sbjct: 619 ACGDAFTVAIGAES 632
>BC112240-1|AAI12241.1| 692|Homo sapiens NIMA-related kinase 8
protein.
Length = 692
Score = 83.8 bits (198), Expect = 1e-15
Identities = 86/312 (27%), Positives = 134/312 (42%), Gaps = 30/312 (9%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGG 194
GD +A L G + +GS GS G + G +P ++ +G V++A G
Sbjct: 399 GDFFTACLTDRGIIMTFGS-----GSNGCLGHGSL-TDISQPTIVEALLGYEMVQVACGA 452
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAG 254
H++ L+T +F G G+ G+LG L R + +Q VP + Q A RV G
Sbjct: 453 SHVLALSTERELFAWGRGDSGRLG-LGTRESHSCPQQ------VP--MPPGQEAQRVVCG 503
Query: 255 HHATFVLDAQHARLFAFGLNNYGQLGIT----GEKRKTALFSPTECDALRAVG----DDH 306
++ +L L A G N + +LG+ GE+ E + +G D
Sbjct: 504 IDSSMILTVPGQAL-ACGSNRFNKLGLDHLSLGEE-PVPHQQVEEALSFTLLGSAPLDQE 561
Query: 307 AWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA 366
++ LG H+ + A+G Y G ++G+LG + G + + L+ K +A
Sbjct: 562 PLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCK-VQGLEGIKMAMVAC 620
Query: 367 GTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRV-SAGGQHTVLL 425
G + + A+ EVYSWG G+ G+LG ED P +D P V S H L
Sbjct: 621 GDAFTVAIGAESEVYSWGKGARGRLGR-RDEDAGLPRPVQLDETHPYTVTSVSCCHGNTL 679
Query: 426 VEETSSQREPSP 437
+ S EP P
Sbjct: 680 LAVRSVTDEPVP 691
Score = 57.2 bits (132), Expect = 1e-07
Identities = 56/208 (26%), Positives = 86/208 (41%), Gaps = 17/208 (8%)
Query: 43 RGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTF 101
RG ++T G G G LG G + + ++ V AL G ++V V G H +AL + +++ +
Sbjct: 409 RGIIMTFGSGSNGCLGHGS-LTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAW 467
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXX--XXXXXXXXXGDSHSAALLQNGDVYAWGSFRDS 159
G D G LG T + P+Q G S L G A GS R +
Sbjct: 468 GRGDSGRLGLGT--RESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFN 525
Query: 160 HGSMGLVVRGREGKP---CKEPVKIDI-------GEPAVEIASGGDHLVVLTTSGGVFTL 209
+ + G E P +E + + EP + I G H +T SG +T
Sbjct: 526 KLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTF 585
Query: 210 GCGEQGQLGRLAQRSASRDAR-QGFSAL 236
G + GQLG +R + + QG +
Sbjct: 586 GSNQHGQLGTNTRRGSRAPCKVQGLEGI 613
Score = 50.8 bits (116), Expect = 1e-05
Identities = 42/157 (26%), Positives = 64/157 (40%), Gaps = 19/157 (12%)
Query: 44 GRVLTCGQGDVGQLGL-----GEDVVETTKFKYV---TALG------DKIVDVQAGGMHT 89
G+ L CG +LGL GE+ V + + T LG + ++ + G H+
Sbjct: 514 GQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHS 573
Query: 90 IALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGD 149
A+ +SG +TFG N G LG T Q GD+ + A+ +
Sbjct: 574 AAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESE 633
Query: 150 VYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEP 186
VY+WG G+ G + R E PV++D P
Sbjct: 634 VYSWGK-----GARGRLGRRDEDAGLPRPVQLDETHP 665
Score = 48.4 bits (110), Expect = 6e-05
Identities = 28/92 (30%), Positives = 42/92 (45%), Gaps = 1/92 (1%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
VA G T L G I G G LG G + D ++ L + + +A G S+
Sbjct: 396 VACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLT-DISQPTIVEALLGYEMVQVACGASH 454
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNEP 402
A++ E+++WG G G+LG G E + P
Sbjct: 455 VLALSTERELFAWGRGDSGRLGLGTRESHSCP 486
Score = 47.6 bits (108), Expect = 1e-04
Identities = 63/254 (24%), Positives = 95/254 (37%), Gaps = 31/254 (12%)
Query: 190 IASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAA 249
+A G LT G + T G G G LG + S+ +V A +
Sbjct: 396 VACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPT-------IVEALLGYEMVQV 448
Query: 250 RVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWS 309
A H L + LFA+G + G+LG+ G + + C +
Sbjct: 449 ACGASH--VLALSTER-ELFAWGRGDSGRLGL-GTRESHS------CPQQVPMPPGQEAQ 498
Query: 310 AVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAE-------------TLELIPKL 356
V G ++ L GQ A G + +LGL S E TL L
Sbjct: 499 RVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPL 558
Query: 357 QNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEP-TLAAVDSRAPLRV 415
+ +SI GT++S AVT SG+ Y++G G+LGT P + ++ V
Sbjct: 559 DQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMV 618
Query: 416 SAGGQHTVLLVEET 429
+ G TV + E+
Sbjct: 619 ACGDAFTVAIGAES 632
>AY267371-1|AAP04006.1| 692|Homo sapiens NIMA-family kinase NEK8
protein.
Length = 692
Score = 83.8 bits (198), Expect = 1e-15
Identities = 86/312 (27%), Positives = 134/312 (42%), Gaps = 30/312 (9%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGG 194
GD +A L G + +GS GS G + G +P ++ +G V++A G
Sbjct: 399 GDFFTACLTDRGIIMTFGS-----GSNGCLGHGSL-TDISQPTIVEALLGYEMVQVACGA 452
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAG 254
H++ L+T +F G G+ G+LG L R + +Q VP + Q A RV G
Sbjct: 453 SHVLALSTERELFAWGRGDSGRLG-LGTRESHSCPQQ------VP--MPPGQEAQRVVCG 503
Query: 255 HHATFVLDAQHARLFAFGLNNYGQLGIT----GEKRKTALFSPTECDALRAVG----DDH 306
++ +L L A G N + +LG+ GE+ E + +G D
Sbjct: 504 IDSSMILTVPGQAL-ACGSNRFNKLGLDHLSLGEE-PVPHQQVEEALSFTLLGSAPLDQE 561
Query: 307 AWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA 366
++ LG H+ + A+G Y G ++G+LG + G + + L+ K +A
Sbjct: 562 PLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCK-VQGLEGIKMAMVAC 620
Query: 367 GTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRV-SAGGQHTVLL 425
G + + A+ EVYSWG G+ G+LG ED P +D P V S H L
Sbjct: 621 GDAFTVAIGAESEVYSWGKGARGRLGR-RDEDAGLPRPVQLDETHPYTVTSVSCCHGNTL 679
Query: 426 VEETSSQREPSP 437
+ S EP P
Sbjct: 680 LAVRSVTDEPVP 691
Score = 57.2 bits (132), Expect = 1e-07
Identities = 56/208 (26%), Positives = 86/208 (41%), Gaps = 17/208 (8%)
Query: 43 RGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTF 101
RG ++T G G G LG G + + ++ V AL G ++V V G H +AL + +++ +
Sbjct: 409 RGIIMTFGSGSNGCLGHGS-LTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAW 467
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXX--XXXXXXXXXGDSHSAALLQNGDVYAWGSFRDS 159
G D G LG T + P+Q G S L G A GS R +
Sbjct: 468 GRGDSGRLGLGT--RESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFN 525
Query: 160 HGSMGLVVRGREGKP---CKEPVKIDI-------GEPAVEIASGGDHLVVLTTSGGVFTL 209
+ + G E P +E + + EP + I G H +T SG +T
Sbjct: 526 KLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTF 585
Query: 210 GCGEQGQLGRLAQRSASRDAR-QGFSAL 236
G + GQLG +R + + QG +
Sbjct: 586 GSNQHGQLGTNTRRGSRAPCKVQGLEGI 613
Score = 50.8 bits (116), Expect = 1e-05
Identities = 42/157 (26%), Positives = 64/157 (40%), Gaps = 19/157 (12%)
Query: 44 GRVLTCGQGDVGQLGL-----GEDVVETTKFKYV---TALG------DKIVDVQAGGMHT 89
G+ L CG +LGL GE+ V + + T LG + ++ + G H+
Sbjct: 514 GQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHS 573
Query: 90 IALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGD 149
A+ +SG +TFG N G LG T Q GD+ + A+ +
Sbjct: 574 AAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESE 633
Query: 150 VYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEP 186
VY+WG G+ G + R E PV++D P
Sbjct: 634 VYSWGK-----GARGRLGRRDEDAGLPRPVQLDETHP 665
Score = 48.4 bits (110), Expect = 6e-05
Identities = 28/92 (30%), Positives = 42/92 (45%), Gaps = 1/92 (1%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
VA G T L G I G G LG G + D ++ L + + +A G S+
Sbjct: 396 VACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLT-DISQPTIVEALLGYEMVQVACGASH 454
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNEP 402
A++ E+++WG G G+LG G E + P
Sbjct: 455 VLALSTERELFAWGRGDSGRLGLGTRESHSCP 486
Score = 47.6 bits (108), Expect = 1e-04
Identities = 63/254 (24%), Positives = 95/254 (37%), Gaps = 31/254 (12%)
Query: 190 IASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAA 249
+A G LT G + T G G G LG + S+ +V A +
Sbjct: 396 VACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPT-------IVEALLGYEMVQV 448
Query: 250 RVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWS 309
A H L + LFA+G + G+LG+ G + + C +
Sbjct: 449 ACGASH--VLALSTER-ELFAWGRGDSGRLGL-GTRESHS------CPQQVPMPPGQEAQ 498
Query: 310 AVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAE-------------TLELIPKL 356
V G ++ L GQ A G + +LGL S E TL L
Sbjct: 499 RVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPL 558
Query: 357 QNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEP-TLAAVDSRAPLRV 415
+ +SI GT++S AVT SG+ Y++G G+LGT P + ++ V
Sbjct: 559 DQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMV 618
Query: 416 SAGGQHTVLLVEET 429
+ G TV + E+
Sbjct: 619 ACGDAFTVAIGAES 632
>AY242354-1|AAO88243.1| 692|Homo sapiens NIMA-related kinase 12a
protein.
Length = 692
Score = 83.8 bits (198), Expect = 1e-15
Identities = 86/312 (27%), Positives = 134/312 (42%), Gaps = 30/312 (9%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGG 194
GD +A L G + +GS GS G + G +P ++ +G V++A G
Sbjct: 399 GDFFTACLTDRGIIMTFGS-----GSNGCLGHGSL-TDISQPTIVEALLGYEMVQVACGA 452
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAG 254
H++ L+T +F G G+ G+LG L R + +Q VP + Q A RV G
Sbjct: 453 SHVLALSTERELFAWGRGDSGRLG-LGTRESHSCPQQ------VP--MPPGQEAQRVVCG 503
Query: 255 HHATFVLDAQHARLFAFGLNNYGQLGIT----GEKRKTALFSPTECDALRAVG----DDH 306
++ +L L A G N + +LG+ GE+ E + +G D
Sbjct: 504 IDSSMILTVPGQAL-ACGSNRFNKLGLDHLSLGEE-PVPHQQVEEALSFTLLGSAPLDQE 561
Query: 307 AWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAA 366
++ LG H+ + A+G Y G ++G+LG + G + + L+ K +A
Sbjct: 562 PLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCK-VQGLEGIKMAMVAC 620
Query: 367 GTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRV-SAGGQHTVLL 425
G + + A+ EVYSWG G+ G+LG ED P +D P V S H L
Sbjct: 621 GDAFTVAIGAESEVYSWGKGARGRLGR-RDEDAGLPRPVQLDETHPYTVTSVSCCHGNTL 679
Query: 426 VEETSSQREPSP 437
+ S EP P
Sbjct: 680 LAVRSVTDEPVP 691
Score = 57.2 bits (132), Expect = 1e-07
Identities = 56/208 (26%), Positives = 86/208 (41%), Gaps = 17/208 (8%)
Query: 43 RGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTF 101
RG ++T G G G LG G + + ++ V AL G ++V V G H +AL + +++ +
Sbjct: 409 RGIIMTFGSGSNGCLGHGS-LTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAW 467
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXX--XXXXXXXXXGDSHSAALLQNGDVYAWGSFRDS 159
G D G LG T + P+Q G S L G A GS R +
Sbjct: 468 GRGDSGRLGLGT--RESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFN 525
Query: 160 HGSMGLVVRGREGKP---CKEPVKIDI-------GEPAVEIASGGDHLVVLTTSGGVFTL 209
+ + G E P +E + + EP + I G H +T SG +T
Sbjct: 526 KLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTF 585
Query: 210 GCGEQGQLGRLAQRSASRDAR-QGFSAL 236
G + GQLG +R + + QG +
Sbjct: 586 GSNQHGQLGTNTRRGSRAPCKVQGLEGI 613
Score = 50.8 bits (116), Expect = 1e-05
Identities = 42/157 (26%), Positives = 64/157 (40%), Gaps = 19/157 (12%)
Query: 44 GRVLTCGQGDVGQLGL-----GEDVVETTKFKYV---TALG------DKIVDVQAGGMHT 89
G+ L CG +LGL GE+ V + + T LG + ++ + G H+
Sbjct: 514 GQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHS 573
Query: 90 IALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGD 149
A+ +SG +TFG N G LG T Q GD+ + A+ +
Sbjct: 574 AAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESE 633
Query: 150 VYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEP 186
VY+WG G+ G + R E PV++D P
Sbjct: 634 VYSWGK-----GARGRLGRRDEDAGLPRPVQLDETHP 665
Score = 48.4 bits (110), Expect = 6e-05
Identities = 28/92 (30%), Positives = 42/92 (45%), Gaps = 1/92 (1%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
VA G T L G I G G LG G + D ++ L + + +A G S+
Sbjct: 396 VACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLT-DISQPTIVEALLGYEMVQVACGASH 454
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNEP 402
A++ E+++WG G G+LG G E + P
Sbjct: 455 VLALSTERELFAWGRGDSGRLGLGTRESHSCP 486
Score = 47.6 bits (108), Expect = 1e-04
Identities = 63/254 (24%), Positives = 95/254 (37%), Gaps = 31/254 (12%)
Query: 190 IASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAA 249
+A G LT G + T G G G LG + S+ +V A +
Sbjct: 396 VACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPT-------IVEALLGYEMVQV 448
Query: 250 RVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWS 309
A H L + LFA+G + G+LG+ G + + C +
Sbjct: 449 ACGASH--VLALSTER-ELFAWGRGDSGRLGL-GTRESHS------CPQQVPMPPGQEAQ 498
Query: 310 AVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAE-------------TLELIPKL 356
V G ++ L GQ A G + +LGL S E TL L
Sbjct: 499 RVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPL 558
Query: 357 QNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEP-TLAAVDSRAPLRV 415
+ +SI GT++S AVT SG+ Y++G G+LGT P + ++ V
Sbjct: 559 DQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMV 618
Query: 416 SAGGQHTVLLVEET 429
+ G TV + E+
Sbjct: 619 ACGDAFTVAIGAES 632
>BC053908-1|AAH53908.1| 522|Homo sapiens RCC2 protein protein.
Length = 522
Score = 83.4 bits (197), Expect = 2e-15
Identities = 90/392 (22%), Positives = 167/392 (42%), Gaps = 50/392 (12%)
Query: 70 KYVTALGDKIVDVQAGGM--HTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXX 127
+Y G ++ V +G H++ + + GK+W++G N++G LG + + +
Sbjct: 141 RYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLS 200
Query: 128 XXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDI-GEP 186
G +H+ AL + G V+A+G + G +GL G + P +I G+P
Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGL---GNQTDAVPSPAQIMYNGQP 255
Query: 187 AVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQ-RSASRDARQGFSALLVPARVTL- 244
++A G + +++ G +++ GC E GQLG + + +R R + LVP RV +
Sbjct: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
Query: 245 -------------RQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALF 291
V G + T VLD+Q R+F++G YG+LG +K +
Sbjct: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQ-KRVFSWGFGGYGRLGHAEQKDEMV-- 372
Query: 292 SPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLE 351
L + D A + +T + A + E G L + +
Sbjct: 373 -----PRLVKLFDFPGRGASQIYAGYTCSFAVS---------EVGGLFFWGATNTSREST 418
Query: 352 LIPKLQNKKC----ISIAAGTSNSFAVTDSGEVYSWGMG-SEGKLGTGESEDLNEPT--- 403
+ PK C S+A G S+ D + SWG + G+LG G+ + +
Sbjct: 419 MYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQE 477
Query: 404 LAAVDSRAPLRVSAGGQHTVLLV-EETSSQRE 434
+ +D +V+ G H++++ +E+ +++E
Sbjct: 478 VKTLDGIFSEQVAMGYSHSLVIARDESETEKE 509
Score = 42.7 bits (96), Expect = 0.003
Identities = 20/67 (29%), Positives = 31/67 (46%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGC 103
G V G+ +GQLGLG + G I + G ++ +D G +++FGC
Sbjct: 221 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGC 280
Query: 104 NDEGALG 110
+ G LG
Sbjct: 281 PEYGQLG 287
Score = 40.3 bits (90), Expect = 0.016
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 7/104 (6%)
Query: 64 VETTKFKYVTALGDKIV-DVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTP 122
+E TK + + + +V DV G HT+ LDS +++++G G LG A +KDE P
Sbjct: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHA--EQKDEMVP 373
Query: 123 KQXXX----XXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
+ G + S A+ + G ++ WG+ S S
Sbjct: 374 RLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRES 417
>BC042141-1|AAH42141.1| 522|Homo sapiens regulator of chromosome
condensation 2 protein.
Length = 522
Score = 83.4 bits (197), Expect = 2e-15
Identities = 90/392 (22%), Positives = 167/392 (42%), Gaps = 50/392 (12%)
Query: 70 KYVTALGDKIVDVQAGGM--HTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXX 127
+Y G ++ V +G H++ + + GK+W++G N++G LG + + +
Sbjct: 141 RYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLS 200
Query: 128 XXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDI-GEP 186
G +H+ AL + G V+A+G + G +GL G + P +I G+P
Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGL---GNQTDAVPSPAQIMYNGQP 255
Query: 187 AVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQ-RSASRDARQGFSALLVPARVTL- 244
++A G + +++ G +++ GC E GQLG + + +R R + LVP RV +
Sbjct: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
Query: 245 -------------RQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALF 291
V G + T VLD+Q R+F++G YG+LG +K +
Sbjct: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQ-KRVFSWGFGGYGRLGHAEQKDEMV-- 372
Query: 292 SPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLE 351
L + D A + +T + A + E G L + +
Sbjct: 373 -----PRLVKLFDFPGRGASQIYAGYTCSFAVS---------EVGGLFFWGATNTSREST 418
Query: 352 LIPKLQNKKC----ISIAAGTSNSFAVTDSGEVYSWGMG-SEGKLGTGESEDLNEPT--- 403
+ PK C S+A G S+ D + SWG + G+LG G+ + +
Sbjct: 419 MYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQE 477
Query: 404 LAAVDSRAPLRVSAGGQHTVLLV-EETSSQRE 434
+ +D +V+ G H++++ +E+ +++E
Sbjct: 478 VKTLDGIFSEQVAMGYSHSLVIARDESETEKE 509
Score = 42.7 bits (96), Expect = 0.003
Identities = 20/67 (29%), Positives = 31/67 (46%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGC 103
G V G+ +GQLGLG + G I + G ++ +D G +++FGC
Sbjct: 221 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGC 280
Query: 104 NDEGALG 110
+ G LG
Sbjct: 281 PEYGQLG 287
Score = 40.3 bits (90), Expect = 0.016
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 7/104 (6%)
Query: 64 VETTKFKYVTALGDKIV-DVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTP 122
+E TK + + + +V DV G HT+ LDS +++++G G LG A +KDE P
Sbjct: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHA--EQKDEMVP 373
Query: 123 KQXXX----XXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
+ G + S A+ + G ++ WG+ S S
Sbjct: 374 RLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRES 417
>AJ421269-1|CAD13148.1| 522|Homo sapiens RCC1-like protein protein.
Length = 522
Score = 83.4 bits (197), Expect = 2e-15
Identities = 90/392 (22%), Positives = 167/392 (42%), Gaps = 50/392 (12%)
Query: 70 KYVTALGDKIVDVQAGGM--HTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXX 127
+Y G ++ V +G H++ + + GK+W++G N++G LG + + +
Sbjct: 141 RYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLS 200
Query: 128 XXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDI-GEP 186
G +H+ AL + G V+A+G + G +GL G + P +I G+P
Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGL---GNQTDAVPSPAQIMYNGQP 255
Query: 187 AVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQ-RSASRDARQGFSALLVPARVTL- 244
++A G + +++ G +++ GC E GQLG + + +R R + LVP RV +
Sbjct: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
Query: 245 -------------RQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALF 291
V G + T VLD+Q R+F++G YG+LG +K +
Sbjct: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQ-KRVFSWGFGGYGRLGHAEQKDEMV-- 372
Query: 292 SPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLE 351
L + D A + +T + A + E G L + +
Sbjct: 373 -----PRLVKLFDFPGRGASQIYAGYTCSFAVS---------EVGGLFFWGATNTSREST 418
Query: 352 LIPKLQNKKC----ISIAAGTSNSFAVTDSGEVYSWGMG-SEGKLGTGESEDLNEPT--- 403
+ PK C S+A G S+ D + SWG + G+LG G+ + +
Sbjct: 419 MYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQE 477
Query: 404 LAAVDSRAPLRVSAGGQHTVLLV-EETSSQRE 434
+ +D +V+ G H++++ +E+ +++E
Sbjct: 478 VKTLDGIFSEQVAMGYSHSLVIARDESETEKE 509
Score = 42.7 bits (96), Expect = 0.003
Identities = 20/67 (29%), Positives = 31/67 (46%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGC 103
G V G+ +GQLGLG + G I + G ++ +D G +++FGC
Sbjct: 221 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGC 280
Query: 104 NDEGALG 110
+ G LG
Sbjct: 281 PEYGQLG 287
Score = 40.3 bits (90), Expect = 0.016
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 7/104 (6%)
Query: 64 VETTKFKYVTALGDKIV-DVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTP 122
+E TK + + + +V DV G HT+ LDS +++++G G LG A +KDE P
Sbjct: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHA--EQKDEMVP 373
Query: 123 KQXXX----XXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
+ G + S A+ + G ++ WG+ S S
Sbjct: 374 RLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRES 417
>AB040903-1|BAA95994.1| 564|Homo sapiens KIAA1470 protein protein.
Length = 564
Score = 83.4 bits (197), Expect = 2e-15
Identities = 90/392 (22%), Positives = 167/392 (42%), Gaps = 50/392 (12%)
Query: 70 KYVTALGDKIVDVQAGGM--HTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXX 127
+Y G ++ V +G H++ + + GK+W++G N++G LG + + +
Sbjct: 183 RYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLS 242
Query: 128 XXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDI-GEP 186
G +H+ AL + G V+A+G + G +GL G + P +I G+P
Sbjct: 243 HEVIVSAACGRNHTLALTETGSVFAFGE--NKMGQLGL---GNQTDAVPSPAQIMYNGQP 297
Query: 187 AVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQ-RSASRDARQGFSALLVPARVTL- 244
++A G + +++ G +++ GC E GQLG + + +R R + LVP RV +
Sbjct: 298 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 357
Query: 245 -------------RQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALF 291
V G + T VLD+Q R+F++G YG+LG +K +
Sbjct: 358 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQ-KRVFSWGFGGYGRLGHAEQKDEMV-- 414
Query: 292 SPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLE 351
L + D A + +T + A + E G L + +
Sbjct: 415 -----PRLVKLFDFPGRGASQIYAGYTCSFAVS---------EVGGLFFWGATNTSREST 460
Query: 352 LIPKLQNKKC----ISIAAGTSNSFAVTDSGEVYSWGMG-SEGKLGTGESEDLNEPT--- 403
+ PK C S+A G S+ D + SWG + G+LG G+ + +
Sbjct: 461 MYPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQE 519
Query: 404 LAAVDSRAPLRVSAGGQHTVLLV-EETSSQRE 434
+ +D +V+ G H++++ +E+ +++E
Sbjct: 520 VKTLDGIFSEQVAMGYSHSLVIARDESETEKE 551
Score = 42.7 bits (96), Expect = 0.003
Identities = 20/67 (29%), Positives = 31/67 (46%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGC 103
G V G+ +GQLGLG + G I + G ++ +D G +++FGC
Sbjct: 263 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGC 322
Query: 104 NDEGALG 110
+ G LG
Sbjct: 323 PEYGQLG 329
Score = 40.3 bits (90), Expect = 0.016
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 7/104 (6%)
Query: 64 VETTKFKYVTALGDKIV-DVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTP 122
+E TK + + + +V DV G HT+ LDS +++++G G LG A +KDE P
Sbjct: 358 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHA--EQKDEMVP 415
Query: 123 KQXXX----XXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
+ G + S A+ + G ++ WG+ S S
Sbjct: 416 RLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRES 459
>AL359612-1|CAB94882.1| 333|Homo sapiens hypothetical protein
protein.
Length = 333
Score = 82.2 bits (194), Expect = 4e-15
Identities = 57/214 (26%), Positives = 100/214 (46%), Gaps = 22/214 (10%)
Query: 88 HTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQN 147
H++ + + GK+W++G N++G LG + + + G +H+ AL +
Sbjct: 17 HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTET 76
Query: 148 GDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDI-GEPAVEIASGGDHLVVLTTSGGV 206
G V+A+G + G +GL G + P +I G+P ++A G + +++ G +
Sbjct: 77 GSVFAFGE--NKMGQLGL---GNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNL 131
Query: 207 FTLGCGEQGQLGRLAQ-RSASRDARQGFSALLVPARVTL--------------RQAAARV 251
++ GC E GQLG + + +R R + LVP RV + V
Sbjct: 132 YSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDV 191
Query: 252 WAGHHATFVLDAQHARLFAFGLNNYGQLGITGEK 285
G + T VLD+Q R+F++G YG+LG +K
Sbjct: 192 ACGANHTLVLDSQ-KRVFSWGFGGYGRLGHAEQK 224
Score = 66.9 bits (156), Expect = 2e-10
Identities = 71/276 (25%), Positives = 120/276 (43%), Gaps = 38/276 (13%)
Query: 139 SHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDH 196
+HS + G +++WG R+ G +G G + K + P I+ E V A G +H
Sbjct: 16 AHSLLITTEGKLWSWG--RNEKGQLG---HG-DTKRVEAPRLIEGLSHEVIVSAACGRNH 69
Query: 197 LVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLR-QAAARVWAGH 255
+ LT +G VF G + GQLG L ++ A+ PA++ Q ++ G
Sbjct: 70 TLALTETGSVFAFGENKMGQLG-LGNQT---------DAVPSPAQIMYNGQPITKMACGA 119
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGE-----------------KRKTALFSPTECDA 298
+ ++D + L++FG YGQLG + R+ A+F D
Sbjct: 120 EFSMIMDCK-GNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDG 178
Query: 299 LRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGD-AETLELIPKLQ 357
+ VA G +HTL L + ++++ G YGRLG ++ + L +
Sbjct: 179 QILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFP 238
Query: 358 NKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGT 393
+ I AG + SFAV++ G ++ WG + + T
Sbjct: 239 GRGASQIYAGYTCSFAVSEVGGLFFWGATNTSREST 274
Score = 58.8 bits (136), Expect = 4e-08
Identities = 30/110 (27%), Positives = 61/110 (55%), Gaps = 2/110 (1%)
Query: 317 HTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTD 376
H+L + G++++ GR E G+LG GD E LI L ++ +S A G +++ A+T+
Sbjct: 17 HSLLITTEGKLWSWGRNEKGQLGHGDTKR-VEAPRLIEGLSHEVIVSAACGRNHTLALTE 75
Query: 377 SGEVYSWGMGSEGKLGTGESED-LNEPTLAAVDSRAPLRVSAGGQHTVLL 425
+G V+++G G+LG G D + P + + +++ G + ++++
Sbjct: 76 TGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIM 125
Score = 52.8 bits (121), Expect = 3e-06
Identities = 57/232 (24%), Positives = 99/232 (42%), Gaps = 40/232 (17%)
Query: 196 HLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGH 255
H +++TT G +++ G E+GQLG D ++ + L+ + G
Sbjct: 17 HSLLITTEGKLWSWGRNEKGQLGH-------GDTKRVEAPRLIEG--LSHEVIVSAACGR 67
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
+ T L + +FAFG N GQLG+ + A+ SP + + + + +A G
Sbjct: 68 NHTLAL-TETGSVFAFGENKMGQLGLGNQT--DAVPSPAQI-----MYNGQPITKMACGA 119
Query: 316 HHTLTLAANGQIYALGRCEYGRLGL---GDKSGDAETLE----LIPK------------- 355
++ + G +Y+ G EYG+LG G A+ +E L+P+
Sbjct: 120 EFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQ 179
Query: 356 ---LQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTL 404
+ N +A G +++ + V+SWG G G+LG E +D P L
Sbjct: 180 ILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 231
Score = 46.4 bits (105), Expect = 2e-04
Identities = 62/257 (24%), Positives = 108/257 (42%), Gaps = 38/257 (14%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWTFG 102
G++ + G+ + GQLG G D + + L + IV G HT+AL +G ++ FG
Sbjct: 25 GKLWSWGRNEKGQLGHG-DTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFG 83
Query: 103 CNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGS---FRDS 159
N G LG + + G S + G++Y++G +
Sbjct: 84 ENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLG 143
Query: 160 HGSMG-LVVRGR------EGKPCKEPVKID-------IGEPAV---EIASGGDHLVVLTT 202
H S G + R + E P + + I+ + P V ++A G +H +VL +
Sbjct: 144 HNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDS 203
Query: 203 SGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTL----RQAAARVWAGHHAT 258
VF+ G G G+LG Q+ +VP V L + A++++AG+ +
Sbjct: 204 QKRVFSWGFGGYGRLGHAEQKDE-----------MVPRLVKLFDFPGRGASQIYAGYTCS 252
Query: 259 FVLDAQHARLFAFGLNN 275
F + ++ LF +G N
Sbjct: 253 FAV-SEVGGLFFWGATN 268
Score = 40.3 bits (90), Expect = 0.016
Identities = 19/63 (30%), Positives = 36/63 (57%)
Query: 369 SNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTVLLVEE 428
++S +T G+++SWG +G+LG G+++ + P L S + +A G++ L + E
Sbjct: 16 AHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTE 75
Query: 429 TSS 431
T S
Sbjct: 76 TGS 78
Score = 40.3 bits (90), Expect = 0.016
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 7/104 (6%)
Query: 64 VETTKFKYVTALGDKIV-DVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTP 122
+E TK + + + +V DV G HT+ LDS +++++G G LG A +KDE P
Sbjct: 172 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHA--EQKDEMVP 229
Query: 123 KQXXX----XXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGS 162
+ G + S A+ + G ++ WG+ S S
Sbjct: 230 RLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSRES 273
>AB046813-1|BAB13419.1| 953|Homo sapiens KIAA1593 protein protein.
Length = 953
Score = 79.8 bits (188), Expect = 2e-14
Identities = 65/216 (30%), Positives = 102/216 (47%), Gaps = 18/216 (8%)
Query: 188 VEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQA 247
V++A G H + L+ + VF G + GQLG L + + Q +LL + Q
Sbjct: 36 VQVACGYYHSLALSKASEVFCWGQNKYGQLG-LGTDCKKQTSPQLLKSLL---GIPFMQV 91
Query: 248 AARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHA 307
AA G H+ FVL A +F +G N +GQLG+ E + + P +LR+ +
Sbjct: 92 AA---GGAHS-FVLTLSGA-IFGWGRNKFGQLGLNDENDR---YVPNLLKSLRSQKIVY- 142
Query: 308 WSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAG 367
+ G+ HT L G ++ G YG+LG S + ++ +L IA G
Sbjct: 143 ---ICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVF-ELMGSIVTEIACG 198
Query: 368 TSNSFA-VTDSGEVYSWGMGSEGKLGTGESEDLNEP 402
++ A V SG +YS+G+G G+LGTG + + P
Sbjct: 199 RQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 234
Score = 78.2 bits (184), Expect = 6e-14
Identities = 63/228 (27%), Positives = 99/228 (43%), Gaps = 17/228 (7%)
Query: 68 KFKYVTALGD-KIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPK--Q 124
+ + + +L D +IV V G H++AL + +++ +G N G LG T +K + +P+ +
Sbjct: 23 RIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKK-QTSPQLLK 81
Query: 125 XXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIG 184
G +HS L +G ++ WG R+ G +GL + +K
Sbjct: 82 SLLGIPFMQVAAGGAHSFVLTLSGAIFGWG--RNKFGQLGL--NDENDRYVPNLLKSLRS 137
Query: 185 EPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTL 244
+ V I G DH LT GGVFT G G GQLG S S + L+ + VT
Sbjct: 138 QKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG---HNSTSHEINPRKVFELMGSIVT- 193
Query: 245 RQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFS 292
+ G T R+++FGL GQLG + + F+
Sbjct: 194 -----EIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFT 236
Score = 77.8 bits (183), Expect = 8e-14
Identities = 58/182 (31%), Positives = 83/182 (45%), Gaps = 6/182 (3%)
Query: 39 APKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYV-TALGDKIVDVQAGGMHTIALDSSGK 97
A K V GQ GQLGLG D + T + + + LG + V AGG H+ L SG
Sbjct: 47 ALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGA 106
Query: 98 IWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFR 157
I+ +G N G LG N++ + G+ H+AAL + G V+ +G+
Sbjct: 107 IFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGA-- 164
Query: 158 DSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHL-VVLTTSGGVFTLGCGEQGQ 216
+G +G E P K V +G EIA G H + +SG +++ G G GQ
Sbjct: 165 GGYGQLGHNSTSHEINPRK--VFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQ 222
Query: 217 LG 218
LG
Sbjct: 223 LG 224
Score = 72.5 bits (170), Expect = 3e-12
Identities = 37/119 (31%), Positives = 64/119 (53%), Gaps = 1/119 (0%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
VA G +H+L L+ +++ G+ +YG+LGLG + +L+ L + +AAG ++
Sbjct: 38 VACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAH 97
Query: 371 SFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT-LAAVDSRAPLRVSAGGQHTVLLVEE 428
SF +T SG ++ WG G+LG + D P L ++ S+ + + G HT L +E
Sbjct: 98 SFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKE 156
Score = 52.0 bits (119), Expect = 5e-06
Identities = 32/84 (38%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIA-LDSSGKIWT 100
K G V T G G GQLG E K +G + ++ G HT A + SSG+I++
Sbjct: 155 KEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYS 214
Query: 101 FGCNDEGALGR-ATSNEKDEGTPK 123
FG G LG +TSN K T K
Sbjct: 215 FGLGGNGQLGTGSTSNRKSPFTVK 238
Score = 41.5 bits (93), Expect = 0.007
Identities = 23/75 (30%), Positives = 40/75 (53%), Gaps = 2/75 (2%)
Query: 353 IPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTG-ESEDLNEPTLAAVDSRA 411
I L + + + +A G +S A++ + EV+ WG G+LG G + + P L
Sbjct: 27 IKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGI 86
Query: 412 P-LRVSAGGQHTVLL 425
P ++V+AGG H+ +L
Sbjct: 87 PFMQVAAGGAHSFVL 101
>AL356741-1|CAH74146.1| 907|Homo sapiens hect domain and RLD 4
protein.
Length = 907
Score = 75.8 bits (178), Expect = 3e-13
Identities = 56/175 (32%), Positives = 81/175 (46%), Gaps = 6/175 (3%)
Query: 46 VLTCGQGDVGQLGLGEDVVETTKFKYV-TALGDKIVDVQAGGMHTIALDSSGKIWTFGCN 104
V GQ GQLGLG D + T + + + LG + V AGG H+ L SG I+ +G N
Sbjct: 8 VFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRN 67
Query: 105 DEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMG 164
G LG N++ + G+ H+AAL + G V+ +G+ +G +G
Sbjct: 68 KFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGA--GGYGQLG 125
Query: 165 LVVRGREGKPCKEPVKIDIGEPAVEIASGGDHL-VVLTTSGGVFTLGCGEQGQLG 218
E P K V +G EIA G H + +SG +++ G G GQLG
Sbjct: 126 HNSTSHEINPRK--VFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 178
Score = 70.9 bits (166), Expect = 1e-11
Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 18/198 (9%)
Query: 206 VFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQH 265
VF G + GQLG L + + Q +LL + Q AA G H+ FVL
Sbjct: 8 VFCWGQNKYGQLG-LGTDCKKQTSPQLLKSLL---GIPFMQVAA---GGAHS-FVLTLSG 59
Query: 266 ARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANG 325
A +F +G N +GQLG+ E + + P +LR+ + + G+ HT L G
Sbjct: 60 A-IFGWGRNKFGQLGLNDENDR---YVPNLLKSLRSQKIVY----ICCGEDHTAALTKEG 111
Query: 326 QIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFA-VTDSGEVYSWG 384
++ G YG+LG S + ++ +L IA G ++ A V SG +YS+G
Sbjct: 112 GVFTFGAGGYGQLGHNSTSHEINPRKVF-ELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 170
Query: 385 MGSEGKLGTGESEDLNEP 402
+G G+LGTG + + P
Sbjct: 171 LGGNGQLGTGSTSNRKSP 188
Score = 65.7 bits (153), Expect = 4e-10
Identities = 55/202 (27%), Positives = 85/202 (42%), Gaps = 16/202 (7%)
Query: 93 DSSGKIWTFGCNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDV 150
+S+ +++ +G N G LG T +K + +P+ + G +HS L +G +
Sbjct: 3 ESASEVFCWGQNKYGQLGLGTDCKK-QTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAI 61
Query: 151 YAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLG 210
+ WG R+ G +GL + +K + V I G DH LT GGVFT G
Sbjct: 62 FGWG--RNKFGQLGL--NDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFG 117
Query: 211 CGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFA 270
G GQLG S S + L+ + VT + G T R+++
Sbjct: 118 AGGYGQLG---HNSTSHEINPRKVFELMGSIVT------EIACGRQHTSAFVPSSGRIYS 168
Query: 271 FGLNNYGQLGITGEKRKTALFS 292
FGL GQLG + + F+
Sbjct: 169 FGLGGNGQLGTGSTSNRKSPFT 190
Score = 60.9 bits (141), Expect = 1e-08
Identities = 31/104 (29%), Positives = 55/104 (52%), Gaps = 1/104 (0%)
Query: 326 QIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGM 385
+++ G+ +YG+LGLG + +L+ L + +AAG ++SF +T SG ++ WG
Sbjct: 7 EVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGR 66
Query: 386 GSEGKLGTGESEDLNEPT-LAAVDSRAPLRVSAGGQHTVLLVEE 428
G+LG + D P L ++ S+ + + G HT L +E
Sbjct: 67 NKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKE 110
Score = 52.0 bits (119), Expect = 5e-06
Identities = 32/84 (38%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIA-LDSSGKIWT 100
K G V T G G GQLG E K +G + ++ G HT A + SSG+I++
Sbjct: 109 KEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYS 168
Query: 101 FGCNDEGALGR-ATSNEKDEGTPK 123
FG G LG +TSN K T K
Sbjct: 169 FGLGGNGQLGTGSTSNRKSPFTVK 192
Score = 43.2 bits (97), Expect = 0.002
Identities = 28/112 (25%), Positives = 47/112 (41%), Gaps = 1/112 (0%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGC 103
G + G+ GQLGL ++ + KIV + G HT AL G ++TFG
Sbjct: 59 GAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGA 118
Query: 104 NDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALL-QNGDVYAWG 154
G LG +++ + G H++A + +G +Y++G
Sbjct: 119 GGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 170
>AL133551-1|CAI16031.1| 907|Homo sapiens hect domain and RLD 4
protein.
Length = 907
Score = 75.8 bits (178), Expect = 3e-13
Identities = 56/175 (32%), Positives = 81/175 (46%), Gaps = 6/175 (3%)
Query: 46 VLTCGQGDVGQLGLGEDVVETTKFKYV-TALGDKIVDVQAGGMHTIALDSSGKIWTFGCN 104
V GQ GQLGLG D + T + + + LG + V AGG H+ L SG I+ +G N
Sbjct: 8 VFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRN 67
Query: 105 DEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMG 164
G LG N++ + G+ H+AAL + G V+ +G+ +G +G
Sbjct: 68 KFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGA--GGYGQLG 125
Query: 165 LVVRGREGKPCKEPVKIDIGEPAVEIASGGDHL-VVLTTSGGVFTLGCGEQGQLG 218
E P K V +G EIA G H + +SG +++ G G GQLG
Sbjct: 126 HNSTSHEINPRK--VFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 178
Score = 70.9 bits (166), Expect = 1e-11
Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 18/198 (9%)
Query: 206 VFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQH 265
VF G + GQLG L + + Q +LL + Q AA G H+ FVL
Sbjct: 8 VFCWGQNKYGQLG-LGTDCKKQTSPQLLKSLL---GIPFMQVAA---GGAHS-FVLTLSG 59
Query: 266 ARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANG 325
A +F +G N +GQLG+ E + + P +LR+ + + G+ HT L G
Sbjct: 60 A-IFGWGRNKFGQLGLNDENDR---YVPNLLKSLRSQKIVY----ICCGEDHTAALTKEG 111
Query: 326 QIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFA-VTDSGEVYSWG 384
++ G YG+LG S + ++ +L IA G ++ A V SG +YS+G
Sbjct: 112 GVFTFGAGGYGQLGHNSTSHEINPRKVF-ELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 170
Query: 385 MGSEGKLGTGESEDLNEP 402
+G G+LGTG + + P
Sbjct: 171 LGGNGQLGTGSTSNRKSP 188
Score = 65.7 bits (153), Expect = 4e-10
Identities = 55/202 (27%), Positives = 85/202 (42%), Gaps = 16/202 (7%)
Query: 93 DSSGKIWTFGCNDEGALGRATSNEKDEGTPK--QXXXXXXXXXXXXGDSHSAALLQNGDV 150
+S+ +++ +G N G LG T +K + +P+ + G +HS L +G +
Sbjct: 3 ESASEVFCWGQNKYGQLGLGTDCKK-QTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAI 61
Query: 151 YAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLG 210
+ WG R+ G +GL + +K + V I G DH LT GGVFT G
Sbjct: 62 FGWG--RNKFGQLGL--NDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFG 117
Query: 211 CGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFA 270
G GQLG S S + L+ + VT + G T R+++
Sbjct: 118 AGGYGQLG---HNSTSHEINPRKVFELMGSIVT------EIACGRQHTSAFVPSSGRIYS 168
Query: 271 FGLNNYGQLGITGEKRKTALFS 292
FGL GQLG + + F+
Sbjct: 169 FGLGGNGQLGTGSTSNRKSPFT 190
Score = 60.9 bits (141), Expect = 1e-08
Identities = 31/104 (29%), Positives = 55/104 (52%), Gaps = 1/104 (0%)
Query: 326 QIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGM 385
+++ G+ +YG+LGLG + +L+ L + +AAG ++SF +T SG ++ WG
Sbjct: 7 EVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGR 66
Query: 386 GSEGKLGTGESEDLNEPT-LAAVDSRAPLRVSAGGQHTVLLVEE 428
G+LG + D P L ++ S+ + + G HT L +E
Sbjct: 67 NKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKE 110
Score = 52.0 bits (119), Expect = 5e-06
Identities = 32/84 (38%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIA-LDSSGKIWT 100
K G V T G G GQLG E K +G + ++ G HT A + SSG+I++
Sbjct: 109 KEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYS 168
Query: 101 FGCNDEGALGR-ATSNEKDEGTPK 123
FG G LG +TSN K T K
Sbjct: 169 FGLGGNGQLGTGSTSNRKSPFTVK 192
Score = 43.2 bits (97), Expect = 0.002
Identities = 28/112 (25%), Positives = 47/112 (41%), Gaps = 1/112 (0%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGC 103
G + G+ GQLGL ++ + KIV + G HT AL G ++TFG
Sbjct: 59 GAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGA 118
Query: 104 NDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALL-QNGDVYAWG 154
G LG +++ + G H++A + +G +Y++G
Sbjct: 119 GGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 170
>BC040929-1|AAH40929.1| 651|Homo sapiens HERC1 protein protein.
Length = 651
Score = 72.5 bits (170), Expect = 3e-12
Identities = 49/166 (29%), Positives = 78/166 (46%), Gaps = 9/166 (5%)
Query: 271 FGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYAL 330
FG +YG+LG+ TA SP + D L +G VA G ++ L +G +Y
Sbjct: 1 FGDGDYGKLGLGNS---TAKSSPQKIDVLCGIGI----KKVACGTQFSVALTKDGHVYTF 53
Query: 331 GRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGK 390
G+ L G ++ + + IP L +A G ++ A+ +G+VY+WG SEG+
Sbjct: 54 GQDRLIGLPEG-RARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQ 112
Query: 391 LGTGESEDLNEPTL-AAVDSRAPLRVSAGGQHTVLLVEETSSQREP 435
LG G + + EPTL + + ++SAG H+ R P
Sbjct: 113 LGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAP 158
Score = 65.3 bits (152), Expect = 5e-10
Identities = 39/118 (33%), Positives = 55/118 (46%), Gaps = 6/118 (5%)
Query: 50 GQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGAL 109
G GD G+LGLG +++ K G I V G ++AL G ++TFG + +
Sbjct: 2 GDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFG--QDRLI 59
Query: 110 GRATSNEKDEGTPKQX--XXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGL 165
G ++ P+Q G H+ AL NGDVYAWGS +S G +GL
Sbjct: 60 GLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGS--NSEGQLGL 115
Score = 47.6 bits (108), Expect = 1e-04
Identities = 36/116 (31%), Positives = 46/116 (39%)
Query: 28 KRGAIQLEIPTAPKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGM 87
K+ A + A K G V T GQ + L G + G I DV G
Sbjct: 32 KKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAE 91
Query: 88 HTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAA 143
HT+AL S+G ++ +G N EG LG +N E T G HSAA
Sbjct: 92 HTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAA 147
Score = 33.9 bits (74), Expect = 1.4
Identities = 45/153 (29%), Positives = 66/153 (43%), Gaps = 14/153 (9%)
Query: 160 HGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGR 219
+G +GL + P K V IG ++A G V LT G V+T G Q +L
Sbjct: 6 YGKLGLGNSTAKSSPQKIDVLCGIG--IKKVACGTQFSVALTKDGHVYTFG---QDRLIG 60
Query: 220 LAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQL 279
L + A R + V A V + A V A H T L A + ++A+G N+ GQL
Sbjct: 61 LPEGRARNHNRP--QQIPVLAGVIIEDVA--VGAEH--TLAL-ASNGDVYAWGSNSEGQL 113
Query: 280 GI--TGEKRKTALFSPTECDALRAVGDDHAWSA 310
G+ T R+ L + + +R + SA
Sbjct: 114 GLGHTNHVREPTLVTGLQGKNVRQISAGRCHSA 146
>BC004933-1|AAH04933.1| 351|Homo sapiens RCC2 protein protein.
Length = 351
Score = 72.5 bits (170), Expect = 3e-12
Identities = 83/361 (22%), Positives = 151/361 (41%), Gaps = 48/361 (13%)
Query: 99 WTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRD 158
W++G N++G LG + + + G +H+ AL + G V+A+G +
Sbjct: 1 WSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGE--N 58
Query: 159 SHGSMGLVVRGREGKPCKEPVKIDI-GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQL 217
G +GL G + P +I G+P ++A G + +++ G +++ GC E GQL
Sbjct: 59 KMGQLGL---GNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQL 115
Query: 218 GRLAQ-RSASRDARQGFSALLVPARVTL--------------RQAAARVWAGHHATFVLD 262
G + + +R R + LVP RV + V G + T VLD
Sbjct: 116 GHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLD 175
Query: 263 AQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLA 322
+Q R+F++G YG+LG +K + L + D A + +T + A
Sbjct: 176 SQ-KRVFSWGFGGYGRLGHAEQKDEMV-------PRLVKLFDFPGRGASQIYAGYTCSFA 227
Query: 323 ANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKC----ISIAAGTSNSFAVTDSG 378
+ E G L + + + PK C S+A G S+ D
Sbjct: 228 VS---------EVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADES 278
Query: 379 EVYSWGMG-SEGKLGTGESEDLNEPT---LAAVDSRAPLRVSAGGQHTVLLV-EETSSQR 433
+ SWG + G+LG G+ + + + +D +V+ G H++++ +E+ +++
Sbjct: 279 TI-SWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESETEK 337
Query: 434 E 434
E
Sbjct: 338 E 338
Score = 44.4 bits (100), Expect = 0.001
Identities = 81/353 (22%), Positives = 140/353 (39%), Gaps = 56/353 (15%)
Query: 50 GQGDVGQLGLGEDVVETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWTFGCNDEGA 108
G+ + GQLG G D + + L + IV G HT+AL +G ++ FG N G
Sbjct: 4 GRNEKGQLGHG-DTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQ 62
Query: 109 LGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGS---FRDSHGSMG- 164
LG + + G S + G++Y++G + H S G
Sbjct: 63 LGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGK 122
Query: 165 LVVRGR------EGKPCKEPVKID-------IGEPAV---EIASGGDHLVVLTTSGGVFT 208
+ R + E P + + I+ + P V ++A G +H +VL + VF+
Sbjct: 123 FIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFS 182
Query: 209 LGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTL----RQAAARVWAGHHATFVLDAQ 264
G G G+LG Q+ +VP V L + A++++AG+ +F + ++
Sbjct: 183 WGFGGYGRLGHAEQKDE-----------MVPRLVKLFDFPGRGASQIYAGYTCSFAV-SE 230
Query: 265 HARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAW--SAVALGQHHTLTLA 322
LF +G N R++ ++ +AV D W ++A G+ + A
Sbjct: 231 VGGLFFWGATN--------TSRESTMYP-------KAVQDLCGWRIRSLACGKSSIIVAA 275
Query: 323 ANGQIYALGRCEYGRLGLGD-KSGDAETLELIPKLQNKKCISIAAGTSNSFAV 374
I +G LG GD K + + + L +A G S+S +
Sbjct: 276 DESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVI 328
Score = 42.7 bits (96), Expect = 0.003
Identities = 20/67 (29%), Positives = 31/67 (46%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGC 103
G V G+ +GQLGLG + G I + G ++ +D G +++FGC
Sbjct: 50 GSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGC 109
Query: 104 NDEGALG 110
+ G LG
Sbjct: 110 PEYGQLG 116
>AJ243951-1|CAB60833.1| 288|Homo sapiens deafness locus associated
putative guanine nucleotide exchange factor protein.
Length = 288
Score = 68.9 bits (161), Expect = 4e-11
Identities = 65/253 (25%), Positives = 108/253 (42%), Gaps = 36/253 (14%)
Query: 150 VYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAV--EIASGGDHLVVLTTSGGVF 207
++AWG+ +S+G +GL G + D +P I GG H V+T G +F
Sbjct: 17 LFAWGA--NSYGQLGL---GHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLF 71
Query: 208 TLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHAR 267
G + GQLG + D P + +V G T +L ++ +
Sbjct: 72 VCGLNKDGQLGL----GHTEDI-----PYFTPCKSLFGCPIQQVACGWDFTIML-TENGQ 121
Query: 268 LFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQI 327
+ + G N++GQLG+ R+ + E + V +A G H + A+G +
Sbjct: 122 VLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVV-------CIAAGLRHAVAATASGIV 174
Query: 328 YALGRCEYGRLGLGDKSGDAETLEL---------IPKLQNKKCISIAAGTSNSFAVTDSG 378
+ G G G + +TL L + L+N K + + AG+ +S ++TD+G
Sbjct: 175 FQWGT---GLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAG 231
Query: 379 EVYSWGMGSEGKL 391
EVY WG G+L
Sbjct: 232 EVYVWGSNKHGQL 244
Score = 61.7 bits (143), Expect = 6e-09
Identities = 70/236 (29%), Positives = 100/236 (42%), Gaps = 18/236 (7%)
Query: 50 GQGDVGQLGLG--EDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGCNDEG 107
G GQLGLG EDV+ + + + GG H+ + G ++ G N +G
Sbjct: 21 GANSYGQLGLGHKEDVLLPQQLNDFCK-PRSVRRITGGGGHSAVVTDGGDLFVCGLNKDG 79
Query: 108 ALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVV 167
LG + + TP + G + L +NG V + GS +S G +G V
Sbjct: 80 QLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS--NSFGQLG-VP 136
Query: 168 RGREGKPCKEPVKIDI-GEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSAS 226
G + C P I++ E V IA+G H V T SG VF G G L +R
Sbjct: 137 HG--PRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTG----LASCGRRLCP 190
Query: 227 RDARQGFSALLVPARVT-LRQAAAR-VWAG-HHATFVLDAQHARLFAFGLNNYGQL 279
F P+RVT L + A V AG H+ + DA ++ +G N +GQL
Sbjct: 191 GQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDA--GEVYVWGSNKHGQL 244
Score = 52.8 bits (121), Expect = 3e-06
Identities = 53/185 (28%), Positives = 75/185 (40%), Gaps = 11/185 (5%)
Query: 44 GRVLTCGQGDVGQLGLG--EDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
G + CG GQLGLG ED+ T K + G I V G TI L +G++ +
Sbjct: 68 GDLFVCGLNKDGQLGLGHTEDIPYFTPCK--SLFGCPIQQVACGWDFTIMLTENGQVLSC 125
Query: 102 GCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHG 161
G N G LG + G H+ A +G V+ WG+ S G
Sbjct: 126 GSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCG 185
Query: 162 SMGLVVRGREGK---PCKEPVKIDIGE--PAVEIASGGDHLVVLTTSGGVFTLGCGEQGQ 216
+ G+ KEP ++ E A+ + +G DH LT +G V+ G + GQ
Sbjct: 186 RR--LCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQ 243
Query: 217 LGRLA 221
L A
Sbjct: 244 LANEA 248
Score = 52.4 bits (120), Expect = 4e-06
Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 1/106 (0%)
Query: 323 ANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYS 382
A ++A G YG+LGLG K +L + + I G +S VTD G+++
Sbjct: 13 AAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFV 72
Query: 383 WGMGSEGKLGTGESEDLNEPTLAAVDSRAPL-RVSAGGQHTVLLVE 427
G+ +G+LG G +ED+ T P+ +V+ G T++L E
Sbjct: 73 CGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTE 118
Score = 50.0 bits (114), Expect = 2e-05
Identities = 46/171 (26%), Positives = 67/171 (39%), Gaps = 18/171 (10%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+ G+VL+CG GQLG+ + + +K+V + AG H +A +SG ++ +
Sbjct: 118 ENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQW 177
Query: 102 G-----CNDEGALGRATSNEKDEGTPKQXXXXXXXXX--XXXGDSHSAALLQNGDVYAWG 154
G C G+ P + G HSA+L G+VY WG
Sbjct: 178 GTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWG 237
Query: 155 SFRDSHGSMGLVVRGREGKPCKEPVKIDI----GEPAVEIASGGDHLVVLT 201
S + HG + E P KI+ E I SG HLV T
Sbjct: 238 S--NKHGQL-----ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQT 281
Score = 47.2 bits (107), Expect = 1e-04
Identities = 38/127 (29%), Positives = 58/127 (45%), Gaps = 7/127 (5%)
Query: 266 ARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANG 325
A LFA+G N+YGQLG+ G K L P + L + + G H+ + G
Sbjct: 15 AALFAWGANSYGQLGL-GHKEDVLL--PQQ---LNDFCKPRSVRRITGGGGHSAVVTDGG 68
Query: 326 QIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGM 385
++ G + G+LGLG + D L +A G + +T++G+V S G
Sbjct: 69 DLFVCGLNKDGQLGLG-HTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS 127
Query: 386 GSEGKLG 392
S G+LG
Sbjct: 128 NSFGQLG 134
Score = 33.9 bits (74), Expect = 1.4
Identities = 18/61 (29%), Positives = 31/61 (50%), Gaps = 2/61 (3%)
Query: 369 SNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLA--AVDSRAPLRVSAGGQHTVLLV 426
S S A + +++WG S G+LG G ED+ P R+ R++ GG H+ ++
Sbjct: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVT 65
Query: 427 E 427
+
Sbjct: 66 D 66
>AF225404-1|AAO27482.1| 259|Homo sapiens HERC2 protein.
Length = 259
Score = 68.1 bits (159), Expect = 7e-11
Identities = 47/139 (33%), Positives = 71/139 (51%), Gaps = 14/139 (10%)
Query: 268 LFAFGLNNYGQLG-ITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTL-TLAANG 325
++ +G N+ GQLG I G K K PT C+AL + +G TL + A+G
Sbjct: 129 IYGWGHNHRGQLGGIEGAKVKV----PTPCEALATLRP-----VQLIGGEQTLFAVTADG 179
Query: 326 QIYALGRCEYGRLGLGDKSGDAETLELIPKLQNK--KCISIAAGTSNSFAVTDSGEVYSW 383
++YA G GRLG+G T L+ +Q+ K +++ +G + A++ GEVYSW
Sbjct: 180 KLYATGYGAGGRLGIGGTES-VSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSW 238
Query: 384 GMGSEGKLGTGESEDLNEP 402
G +GKLG G + P
Sbjct: 239 GEAEDGKLGHGNRSPCDRP 257
Score = 55.6 bits (128), Expect = 4e-07
Identities = 34/114 (29%), Positives = 56/114 (49%), Gaps = 4/114 (3%)
Query: 318 TLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDS 377
TL+ +G IY G G+LG G + + L + + + G FAVT
Sbjct: 120 TLSAGGSGTIYGWGHNHRGQLG-GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTAD 178
Query: 378 GEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLR---VSAGGQHTVLLVEE 428
G++Y+ G G+ G+LG G +E ++ PTL ++ V++GG+H + L E
Sbjct: 179 GKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSE 232
Score = 45.6 bits (103), Expect = 4e-04
Identities = 25/77 (32%), Positives = 42/77 (54%), Gaps = 2/77 (2%)
Query: 44 GRVLTCGQGDVGQLGLG--EDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
G++ G G G+LG+G E V T + + + K V V +GG H +AL S G+++++
Sbjct: 179 GKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSW 238
Query: 102 GCNDEGALGRATSNEKD 118
G ++G LG + D
Sbjct: 239 GEAEDGKLGHGNRSPCD 255
Score = 43.2 bits (97), Expect = 0.002
Identities = 33/130 (25%), Positives = 54/130 (41%), Gaps = 2/130 (1%)
Query: 89 TIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNG 148
T++ SG I+ +G N G LG + TP + G+ A+ +G
Sbjct: 120 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADG 179
Query: 149 DVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFT 208
+YA G + G +G+ P + V + SGG H + L++ G V++
Sbjct: 180 KLYATGY--GAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYS 237
Query: 209 LGCGEQGQLG 218
G E G+LG
Sbjct: 238 WGEAEDGKLG 247
>AK092403-1|BAC03879.1| 184|Homo sapiens protein ( Homo sapiens
cDNA FLJ35084 fis, clone PLACE6005482. ).
Length = 184
Score = 65.3 bits (152), Expect = 5e-10
Identities = 34/122 (27%), Positives = 67/122 (54%), Gaps = 4/122 (3%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
V+ G +H+L L+ + Q+++ G+ +G+LGLG + + + + L+ +AAG ++
Sbjct: 11 VSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAH 70
Query: 371 SFAVTDSGEVYSWGMGSEGKL---GTGESEDLNEP-TLAAVDSRAPLRVSAGGQHTVLLV 426
SFA++ G + WG S G+L G N+P ++ A+ + + +S G HT +L
Sbjct: 71 SFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLT 130
Query: 427 EE 428
++
Sbjct: 131 QD 132
Score = 62.1 bits (144), Expect = 4e-09
Identities = 45/146 (30%), Positives = 65/146 (44%), Gaps = 10/146 (6%)
Query: 78 KIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXX--XXXX 135
KI+ V G H++AL +++++G N G LG + +P++
Sbjct: 7 KIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLG-KEFPSQASPQRVRSLEGIPLAQVA 65
Query: 136 XGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRG---REGKPCKEPVKIDIGEPAVEIAS 192
G +HS AL G + WGS +S G + L R + KP ++G V I+
Sbjct: 66 AGGAHSFALSLCGTSFGWGS--NSAGQLALSGRNVPVQSNKPLSVGALKNLG--VVYISC 121
Query: 193 GGDHLVVLTTSGGVFTLGCGEQGQLG 218
G H VLT G VFT G GQLG
Sbjct: 122 GDAHTAVLTQDGKVFTFGDNRSGQLG 147
Score = 54.4 bits (125), Expect = 9e-07
Identities = 39/157 (24%), Positives = 79/157 (50%), Gaps = 9/157 (5%)
Query: 250 RVWAGHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWS 309
+V GH+ + L ++ +++F++G N++GQLG+ E A SP +L + +
Sbjct: 10 QVSCGHYHSLAL-SKDSQVFSWGKNSHGQLGLGKEFPSQA--SPQRVRSLEGI----PLA 62
Query: 310 AVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLE--LIPKLQNKKCISIAAG 367
VA G H+ L+ G + G G+L L ++ ++ + + L+N + I+ G
Sbjct: 63 QVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCG 122
Query: 368 TSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTL 404
+++ +T G+V+++G G+LG + + P L
Sbjct: 123 DAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQL 159
Score = 54.0 bits (124), Expect = 1e-06
Identities = 39/130 (30%), Positives = 59/130 (45%), Gaps = 6/130 (4%)
Query: 39 APKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGK 97
A K +V + G+ GQLGLG++ + V +L G + V AGG H+ AL G
Sbjct: 20 ALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGT 79
Query: 98 IWTFGCNDEGAL---GRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWG 154
+ +G N G L GR + ++ GD+H+A L Q+G V+ +G
Sbjct: 80 SFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFG 139
Query: 155 SFRDSHGSMG 164
R G +G
Sbjct: 140 DNRS--GQLG 147
Score = 42.3 bits (95), Expect = 0.004
Identities = 28/71 (39%), Positives = 38/71 (53%), Gaps = 3/71 (4%)
Query: 50 GQGDVGQLGL-GEDV-VETTKFKYVTALGDK-IVDVQAGGMHTIALDSSGKIWTFGCNDE 106
G GQL L G +V V++ K V AL + +V + G HT L GK++TFG N
Sbjct: 84 GSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRS 143
Query: 107 GALGRATSNEK 117
G LG + + EK
Sbjct: 144 GQLGYSPTPEK 154
Score = 41.9 bits (94), Expect = 0.005
Identities = 21/72 (29%), Positives = 39/72 (54%), Gaps = 2/72 (2%)
Query: 356 LQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGES--EDLNEPTLAAVDSRAPL 413
L + K I ++ G +S A++ +V+SWG S G+LG G+ + + +++
Sbjct: 3 LNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLA 62
Query: 414 RVSAGGQHTVLL 425
+V+AGG H+ L
Sbjct: 63 QVAAGGAHSFAL 74
>AC004460-2|AAC06339.1| 371|Homo sapiens WUGSC:H_DJ1086D14.2
protein.
Length = 371
Score = 61.7 bits (143), Expect = 6e-09
Identities = 41/157 (26%), Positives = 73/157 (46%), Gaps = 9/157 (5%)
Query: 268 LFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQI 327
+F++G ++G+LG G + P + L G + G L L +G +
Sbjct: 3 VFSWGDGDFGKLGRGGSEGCNI---PQNIERLNGQGV----CQIECGAQFLLALTKSGVV 55
Query: 328 YALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGS 387
+ G+ +Y RLG +++ L+ KK + +A G + AV DSG+VY+WG
Sbjct: 56 WTWGKGDYFRLG-HRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDND 114
Query: 388 EGKLGTGESEDLNEPTLA-AVDSRAPLRVSAGGQHTV 423
G+ G G + +P L ++ + + V+ G H+V
Sbjct: 115 HGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSV 151
Score = 59.3 bits (137), Expect = 3e-08
Identities = 43/159 (27%), Positives = 62/159 (38%), Gaps = 4/159 (2%)
Query: 44 GRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTFGC 103
G V + G GD G+LG G G + ++ G +AL SG +WT+G
Sbjct: 1 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 60
Query: 104 NDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSHGSM 163
D LG + + + G H A++ +G VYAWG + HG
Sbjct: 61 GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGD--NDHGQQ 118
Query: 164 GLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTT 202
G KP V+ G+ + +A G H V TT
Sbjct: 119 GNGTTTVNRKPML--VQGLEGQKIMCVACGSSHSVAWTT 155
Score = 52.0 bits (119), Expect = 5e-06
Identities = 36/103 (34%), Positives = 47/103 (45%), Gaps = 2/103 (1%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWT 100
K G V T G+GD +LG DV K + V L G KIV V G H +A+ SG+++
Sbjct: 51 KSGVVWTWGKGDYFRLGHRSDV-HVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYA 109
Query: 101 FGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAA 143
+G ND G G T+ + Q G SHS A
Sbjct: 110 WGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVA 152
Score = 46.4 bits (105), Expect = 2e-04
Identities = 26/104 (25%), Positives = 50/104 (48%), Gaps = 2/104 (1%)
Query: 325 GQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWG 384
G +++ G ++G+LG G G + I +L + I G A+T SG V++WG
Sbjct: 1 GLVFSWGDGDFGKLGRGGSEG-CNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 59
Query: 385 MGSEGKLGTGESEDLNEP-TLAAVDSRAPLRVSAGGQHTVLLVE 427
G +LG + +P + + + + V+ G QH + +++
Sbjct: 60 KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMD 103
>BC019008-1|AAH19008.1| 464|Homo sapiens Williams-Beuren syndrome
chromosome region 16 protein.
Length = 464
Score = 59.3 bits (137), Expect = 3e-08
Identities = 79/301 (26%), Positives = 117/301 (38%), Gaps = 31/301 (10%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGRE--GKPCKEPVKIDIGEPAVEIASGG 194
G +HS L V++ G+ +S+G G V E + + D V++A G
Sbjct: 182 GRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQ 239
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAG 254
DH + LT G V++ G G GQ G S + G A V + Q A G
Sbjct: 240 DHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDL----AGVNVIQVATY---G 292
Query: 255 HHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALG 314
V + LF +G + Y QL + + + C VG A G
Sbjct: 293 DCCLAV--SADGGLFGWGNSEYLQLASVTDSTQVNV---PRCLHFSGVGKVRQ---AACG 344
Query: 315 QHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIP-------KLQNKKCIS-IAA 366
L G ++ G YG LG G ++ E+IP + + +S I
Sbjct: 345 GTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRC 401
Query: 367 GTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTVLLV 426
G S+ A+T+ GE++ WG G LG G ED P + P+ V+ G H V L
Sbjct: 402 GLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGE-PVDVACGVDHMVTLA 460
Query: 427 E 427
+
Sbjct: 461 K 461
Score = 56.0 bits (129), Expect = 3e-07
Identities = 45/176 (25%), Positives = 78/176 (44%), Gaps = 10/176 (5%)
Query: 238 VPARVTLRQAAARVWAGHHATFVLD--AQHARLFAFGLNNYGQLGI-TGEKRKTA----L 290
VP R+ L Q + G+ T + A +++ GLN QLG K KT +
Sbjct: 99 VPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYV 158
Query: 291 FSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET- 349
P+ + V+ G+ H+L L ++++G YG+ G + +
Sbjct: 159 LEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSE 218
Query: 350 LELIPKLQN--KKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT 403
+ ++Q+ + + +A G +S +TD GEVYS G G++G+ G G + PT
Sbjct: 219 SHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPT 274
Score = 53.6 bits (123), Expect = 2e-06
Identities = 59/222 (26%), Positives = 97/222 (43%), Gaps = 16/222 (7%)
Query: 206 VFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTL---RQAAARVW---AGHHATF 259
V+ +G + QLG R +D +G+ +L P+ V+L R RV G +
Sbjct: 131 VWGMGLNKDSQLGFHRSR---KDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSL 187
Query: 260 VLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGD-DHAWSAVALGQHHT 318
VL + +F+ G N+YGQ G + + ++S E + + D D VA GQ H+
Sbjct: 188 VLTDREG-VFSMGNNSYGQCG--RKVVENEIYS--ESHRVHRMQDFDGQVVQVACGQDHS 242
Query: 319 LTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSG 378
L L G++Y+ G G+ GLG + + +L L I +A AV+ G
Sbjct: 243 LFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADG 302
Query: 379 EVYSWGMGSEGKLGT-GESEDLNEPTLAAVDSRAPLRVSAGG 419
++ WG +L + +S +N P +R +A G
Sbjct: 303 GLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344
Score = 48.4 bits (110), Expect = 6e-05
Identities = 62/268 (23%), Positives = 99/268 (36%), Gaps = 17/268 (6%)
Query: 78 KIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGR-ATSNE---KDEGTPKQXXXXXXXXX 133
+++ V G H++ L +++ G N G GR NE + +
Sbjct: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234
Query: 134 XXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASG 193
G HS L G+VY+ G D G GL P K + G +++A+
Sbjct: 235 VACGQDHSLFLTDKGEVYSCGWGAD--GQTGLGHYNITSSPTKLGGDL-AGVNVIQVATY 291
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
GD + ++ GG+F G E QL + + R L +RQAA
Sbjct: 292 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR----CLHFSGVGKVRQAA----C 343
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
G VL+ + +F +G G+ E + PT L + S +
Sbjct: 344 GGTGCAVLNGE-GHVFVWGYGILGKGPNLVESAVPEMIPPT-LFGLTEFNPEIQVSRIRC 401
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLG 341
G H L G+++ G+ G LG+G
Sbjct: 402 GLSHFAALTNKGELFVWGKNIRGCLGIG 429
Score = 40.3 bits (90), Expect = 0.016
Identities = 60/252 (23%), Positives = 99/252 (39%), Gaps = 26/252 (10%)
Query: 150 VYAWGSFRDS----HGSMGLVVRGREGKPCKEPVKIDIGEP----AVEIASGGDHLVVLT 201
V+ G +DS H S RG E PV + + P ++++ G H +VLT
Sbjct: 131 VWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLT 190
Query: 202 TSGGVFTLGCGEQGQLGR-LAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFV 260
GVF++G GQ GR + + ++ + +V Q A H+ F+
Sbjct: 191 DREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVV--QVAC---GQDHSLFL 245
Query: 261 LDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHH--T 318
D +++ G GQ G+ G T+ SPT+ GD + + + +
Sbjct: 246 TD--KGEVYSCGWGADGQTGL-GHYNITS--SPTKLG-----GDLAGVNVIQVATYGDCC 295
Query: 319 LTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSG 378
L ++A+G ++ G EY +L S + K A G + + G
Sbjct: 296 LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEG 355
Query: 379 EVYSWGMGSEGK 390
V+ WG G GK
Sbjct: 356 HVFVWGYGILGK 367
Score = 36.3 bits (80), Expect = 0.25
Identities = 44/183 (24%), Positives = 71/183 (38%), Gaps = 10/183 (5%)
Query: 43 RGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTF 101
+G V +CG G GQ GLG + ++ K L G ++ V G +A+ + G ++ +
Sbjct: 248 KGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGW 307
Query: 102 GCNDEGALGRAT-SNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
G ++ L T S + + G + A L G V+ WG
Sbjct: 308 GNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 367
Query: 161 GSMGLVVRGREGKPCKEPVKIDIGE--PAVEIA---SGGDHLVVLTTSGGVFTLGCGEQG 215
G + E P P + E P ++++ G H LT G +F G +G
Sbjct: 368 GPNLVESAVPEMIP---PTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRG 424
Query: 216 QLG 218
LG
Sbjct: 425 CLG 427
>BC007823-1|AAH07823.1| 464|Homo sapiens Williams-Beuren syndrome
chromosome region 16 protein.
Length = 464
Score = 59.3 bits (137), Expect = 3e-08
Identities = 79/301 (26%), Positives = 117/301 (38%), Gaps = 31/301 (10%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGRE--GKPCKEPVKIDIGEPAVEIASGG 194
G +HS L V++ G+ +S+G G V E + + D V++A G
Sbjct: 182 GRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQ 239
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAG 254
DH + LT G V++ G G GQ G S + G A V + Q A G
Sbjct: 240 DHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDL----AGVNVIQVATY---G 292
Query: 255 HHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALG 314
V + LF +G + Y QL + + + C VG A G
Sbjct: 293 DCCLAV--SADGGLFGWGNSEYLQLASVTDSTQVNV---PRCLHFSGVGKVRQ---AACG 344
Query: 315 QHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIP-------KLQNKKCIS-IAA 366
L G ++ G YG LG G ++ E+IP + + +S I
Sbjct: 345 GTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRC 401
Query: 367 GTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTVLLV 426
G S+ A+T+ GE++ WG G LG G ED P + P+ V+ G H V L
Sbjct: 402 GLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGE-PVDVACGVDHMVTLA 460
Query: 427 E 427
+
Sbjct: 461 K 461
Score = 56.0 bits (129), Expect = 3e-07
Identities = 45/176 (25%), Positives = 78/176 (44%), Gaps = 10/176 (5%)
Query: 238 VPARVTLRQAAARVWAGHHATFVLD--AQHARLFAFGLNNYGQLGI-TGEKRKTA----L 290
VP R+ L Q + G+ T + A +++ GLN QLG K KT +
Sbjct: 99 VPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYV 158
Query: 291 FSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET- 349
P+ + V+ G+ H+L L ++++G YG+ G + +
Sbjct: 159 LEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSE 218
Query: 350 LELIPKLQN--KKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT 403
+ ++Q+ + + +A G +S +TD GEVYS G G++G+ G G + PT
Sbjct: 219 SHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPT 274
Score = 53.6 bits (123), Expect = 2e-06
Identities = 59/222 (26%), Positives = 97/222 (43%), Gaps = 16/222 (7%)
Query: 206 VFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTL---RQAAARVW---AGHHATF 259
V+ +G + QLG R +D +G+ +L P+ V+L R RV G +
Sbjct: 131 VWGMGLNKDSQLGFHRSR---KDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSL 187
Query: 260 VLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGD-DHAWSAVALGQHHT 318
VL + +F+ G N+YGQ G + + ++S E + + D D VA GQ H+
Sbjct: 188 VLTDREG-VFSMGNNSYGQCG--RKVVENEIYS--ESHRVHRMQDFDGQVVQVACGQDHS 242
Query: 319 LTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSG 378
L L G++Y+ G G+ GLG + + +L L I +A AV+ G
Sbjct: 243 LFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADG 302
Query: 379 EVYSWGMGSEGKLGT-GESEDLNEPTLAAVDSRAPLRVSAGG 419
++ WG +L + +S +N P +R +A G
Sbjct: 303 GLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344
Score = 48.4 bits (110), Expect = 6e-05
Identities = 62/268 (23%), Positives = 99/268 (36%), Gaps = 17/268 (6%)
Query: 78 KIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGR-ATSNE---KDEGTPKQXXXXXXXXX 133
+++ V G H++ L +++ G N G GR NE + +
Sbjct: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234
Query: 134 XXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASG 193
G HS L G+VY+ G D G GL P K + G +++A+
Sbjct: 235 VACGQDHSLFLTDKGEVYSCGWGAD--GQTGLGHYNITSSPTKLGGDL-AGVNVIQVATY 291
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
GD + ++ GG+F G E QL + + R L +RQAA
Sbjct: 292 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR----CLHFSGVGKVRQAA----C 343
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
G VL+ + +F +G G+ E + PT L + S +
Sbjct: 344 GGTGCAVLNGE-GHVFVWGYGILGKGPNLVESAVPEMIPPT-LFGLTEFNPEIQVSRIRC 401
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLG 341
G H L G+++ G+ G LG+G
Sbjct: 402 GLSHFAALTNKGELFVWGKNIRGCLGIG 429
Score = 40.3 bits (90), Expect = 0.016
Identities = 60/252 (23%), Positives = 99/252 (39%), Gaps = 26/252 (10%)
Query: 150 VYAWGSFRDS----HGSMGLVVRGREGKPCKEPVKIDIGEP----AVEIASGGDHLVVLT 201
V+ G +DS H S RG E PV + + P ++++ G H +VLT
Sbjct: 131 VWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLT 190
Query: 202 TSGGVFTLGCGEQGQLGR-LAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFV 260
GVF++G GQ GR + + ++ + +V Q A H+ F+
Sbjct: 191 DREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVV--QVAC---GQDHSLFL 245
Query: 261 LDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHH--T 318
D +++ G GQ G+ G T+ SPT+ GD + + + +
Sbjct: 246 TD--KGEVYSCGWGADGQTGL-GHYNITS--SPTKLG-----GDLAGVNVIQVATYGDCC 295
Query: 319 LTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSG 378
L ++A+G ++ G EY +L S + K A G + + G
Sbjct: 296 LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEG 355
Query: 379 EVYSWGMGSEGK 390
V+ WG G GK
Sbjct: 356 HVFVWGYGILGK 367
Score = 36.3 bits (80), Expect = 0.25
Identities = 44/183 (24%), Positives = 71/183 (38%), Gaps = 10/183 (5%)
Query: 43 RGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTF 101
+G V +CG G GQ GLG + ++ K L G ++ V G +A+ + G ++ +
Sbjct: 248 KGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGW 307
Query: 102 GCNDEGALGRAT-SNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
G ++ L T S + + G + A L G V+ WG
Sbjct: 308 GNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 367
Query: 161 GSMGLVVRGREGKPCKEPVKIDIGE--PAVEIA---SGGDHLVVLTTSGGVFTLGCGEQG 215
G + E P P + E P ++++ G H LT G +F G +G
Sbjct: 368 GPNLVESAVPEMIP---PTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRG 424
Query: 216 QLG 218
LG
Sbjct: 425 CLG 427
>AF410455-1|AAM62304.1| 464|Homo sapiens RCC1-like G exchanging
factor-like protein protein.
Length = 464
Score = 59.3 bits (137), Expect = 3e-08
Identities = 79/301 (26%), Positives = 117/301 (38%), Gaps = 31/301 (10%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGRE--GKPCKEPVKIDIGEPAVEIASGG 194
G +HS L V++ G+ +S+G G V E + + D V++A G
Sbjct: 182 GRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQ 239
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAG 254
DH + LT G V++ G G GQ G S + G A V + Q A G
Sbjct: 240 DHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDL----AGVNVIQVATY---G 292
Query: 255 HHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALG 314
V + LF +G + Y QL + + + C VG A G
Sbjct: 293 DCCLAV--SADGGLFGWGNSEYLQLASVTDSTQVNV---PRCLHFSGVGKVRQ---AACG 344
Query: 315 QHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIP-------KLQNKKCIS-IAA 366
L G ++ G YG LG G ++ E+IP + + +S I
Sbjct: 345 GTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRC 401
Query: 367 GTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTVLLV 426
G S+ A+T+ GE++ WG G LG G ED P + P+ V+ G H V L
Sbjct: 402 GLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGE-PVDVACGVDHMVTLA 460
Query: 427 E 427
+
Sbjct: 461 K 461
Score = 56.0 bits (129), Expect = 3e-07
Identities = 45/176 (25%), Positives = 78/176 (44%), Gaps = 10/176 (5%)
Query: 238 VPARVTLRQAAARVWAGHHATFVLD--AQHARLFAFGLNNYGQLGI-TGEKRKTA----L 290
VP R+ L Q + G+ T + A +++ GLN QLG K KT +
Sbjct: 99 VPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYV 158
Query: 291 FSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET- 349
P+ + V+ G+ H+L L ++++G YG+ G + +
Sbjct: 159 LEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSE 218
Query: 350 LELIPKLQN--KKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT 403
+ ++Q+ + + +A G +S +TD GEVYS G G++G+ G G + PT
Sbjct: 219 SHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPT 274
Score = 53.6 bits (123), Expect = 2e-06
Identities = 59/222 (26%), Positives = 97/222 (43%), Gaps = 16/222 (7%)
Query: 206 VFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTL---RQAAARVW---AGHHATF 259
V+ +G + QLG R +D +G+ +L P+ V+L R RV G +
Sbjct: 131 VWGMGLNKDSQLGFHRSR---KDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSL 187
Query: 260 VLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGD-DHAWSAVALGQHHT 318
VL + +F+ G N+YGQ G + + ++S E + + D D VA GQ H+
Sbjct: 188 VLTDREG-VFSMGNNSYGQCG--RKVVENEIYS--ESHRVHRMQDFDGQVVQVACGQDHS 242
Query: 319 LTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSG 378
L L G++Y+ G G+ GLG + + +L L I +A AV+ G
Sbjct: 243 LFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADG 302
Query: 379 EVYSWGMGSEGKLGT-GESEDLNEPTLAAVDSRAPLRVSAGG 419
++ WG +L + +S +N P +R +A G
Sbjct: 303 GLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344
Score = 48.4 bits (110), Expect = 6e-05
Identities = 62/268 (23%), Positives = 99/268 (36%), Gaps = 17/268 (6%)
Query: 78 KIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGR-ATSNE---KDEGTPKQXXXXXXXXX 133
+++ V G H++ L +++ G N G GR NE + +
Sbjct: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234
Query: 134 XXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASG 193
G HS L G+VY+ G D G GL P K + G +++A+
Sbjct: 235 VACGQDHSLFLTDKGEVYSCGWGAD--GQTGLGHYNITSSPTKLGGDL-AGVNVIQVATY 291
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
GD + ++ GG+F G E QL + + R L +RQAA
Sbjct: 292 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR----CLHFSGVGKVRQAA----C 343
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
G VL+ + +F +G G+ E + PT L + S +
Sbjct: 344 GGTGCAVLNGE-GHVFVWGYGILGKGPNLVESAVPEMIPPT-LFGLTEFNPEIQVSRIRC 401
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLG 341
G H L G+++ G+ G LG+G
Sbjct: 402 GLSHFAALTNKGELFVWGKNIRGCLGIG 429
Score = 40.3 bits (90), Expect = 0.016
Identities = 60/252 (23%), Positives = 99/252 (39%), Gaps = 26/252 (10%)
Query: 150 VYAWGSFRDS----HGSMGLVVRGREGKPCKEPVKIDIGEP----AVEIASGGDHLVVLT 201
V+ G +DS H S RG E PV + + P ++++ G H +VLT
Sbjct: 131 VWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLT 190
Query: 202 TSGGVFTLGCGEQGQLGR-LAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFV 260
GVF++G GQ GR + + ++ + +V Q A H+ F+
Sbjct: 191 DREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVV--QVAC---GQDHSLFL 245
Query: 261 LDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHH--T 318
D +++ G GQ G+ G T+ SPT+ GD + + + +
Sbjct: 246 TD--KGEVYSCGWGADGQTGL-GHYNITS--SPTKLG-----GDLAGVNVIQVATYGDCC 295
Query: 319 LTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSG 378
L ++A+G ++ G EY +L S + K A G + + G
Sbjct: 296 LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEG 355
Query: 379 EVYSWGMGSEGK 390
V+ WG G GK
Sbjct: 356 HVFVWGYGILGK 367
Score = 36.3 bits (80), Expect = 0.25
Identities = 44/183 (24%), Positives = 71/183 (38%), Gaps = 10/183 (5%)
Query: 43 RGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTF 101
+G V +CG G GQ GLG + ++ K L G ++ V G +A+ + G ++ +
Sbjct: 248 KGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGW 307
Query: 102 GCNDEGALGRAT-SNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
G ++ L T S + + G + A L G V+ WG
Sbjct: 308 GNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 367
Query: 161 GSMGLVVRGREGKPCKEPVKIDIGE--PAVEIA---SGGDHLVVLTTSGGVFTLGCGEQG 215
G + E P P + E P ++++ G H LT G +F G +G
Sbjct: 368 GPNLVESAVPEMIP---PTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRG 424
Query: 216 QLG 218
LG
Sbjct: 425 CLG 427
>DQ005634-1|AAY55907.1| 1196|Homo sapiens inhibitor of Bruton's
tyrosine kinase-beta protein.
Length = 1196
Score = 58.0 bits (134), Expect = 7e-08
Identities = 73/241 (30%), Positives = 96/241 (39%), Gaps = 28/241 (11%)
Query: 98 IWTFGCNDEGALGRATSNEKD--EGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGS 155
++T+G N LG + N K E HS L Q G VY G
Sbjct: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG- 202
Query: 156 FRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLGCGE 213
HG G + G E + C P ++ G ++A+ DH VVLT G V+T G
Sbjct: 203 ----HGPGGRLGHGDE-QTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNI 257
Query: 214 QGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGL 273
QLG + S+ RQ A + R + AA R H + +A ++ GL
Sbjct: 258 FHQLGIIPPPSSCNVPRQ-IQAKYLKGRTIIGVAAGRF---HTVLWTREA----VYTMGL 309
Query: 274 NNYGQLGI----TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYA 329
N GQLG GEK TA P + AL D A S VA T+ + G IY
Sbjct: 310 NG-GQLGCLLDPNGEKCVTA---PRQVSALH--HKDIALSLVAASDGATVCVTTRGDIYL 363
Query: 330 L 330
L
Sbjct: 364 L 364
Score = 52.0 bits (119), Expect = 5e-06
Identities = 37/122 (30%), Positives = 56/122 (45%), Gaps = 5/122 (4%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
V L + H++ L+ GQ+Y G GRLG GD+ L+ L C +AA +
Sbjct: 182 VVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQ-TCLVPRLVEGLNGHNCSQVAAAKDH 240
Query: 371 SFAVTDSGEVYSWGMGSEGKLG-TGESEDLNEP---TLAAVDSRAPLRVSAGGQHTVLLV 426
+ +T+ G VY++G+ +LG N P + R + V+AG HTVL
Sbjct: 241 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT 300
Query: 427 EE 428
E
Sbjct: 301 RE 302
Score = 40.7 bits (91), Expect = 0.012
Identities = 23/69 (33%), Positives = 32/69 (46%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
++G+V TCG G G+LG G++ G V A HT+ L G ++TF
Sbjct: 194 QKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTF 253
Query: 102 GCNDEGALG 110
G N LG
Sbjct: 254 GLNIFHQLG 262
Score = 33.1 bits (72), Expect = 2.4
Identities = 37/139 (26%), Positives = 61/139 (43%), Gaps = 13/139 (9%)
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
H+ F+ +Q +++ G G+LG E+ T L P + L H S VA +
Sbjct: 188 HSVFL--SQKGQVYTCGHGPGGRLGHGDEQ--TCLV-PRLVEGLNG----HNCSQVAAAK 238
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPK--LQNKKCISIAAGTSNSFA 373
HT+ L +G +Y G + +LG+ I L+ + I +AAG ++
Sbjct: 239 DHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVL 298
Query: 374 VTDSGEVYSWGMGSEGKLG 392
T VY+ G+ G+LG
Sbjct: 299 WTREA-VYTMGLNG-GQLG 315
>DQ005633-1|AAY55906.1| 1353|Homo sapiens inhibitor of Bruton's
tyrosine kinase-alpha protein.
Length = 1353
Score = 58.0 bits (134), Expect = 7e-08
Identities = 73/241 (30%), Positives = 96/241 (39%), Gaps = 28/241 (11%)
Query: 98 IWTFGCNDEGALGRATSNEKD--EGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGS 155
++T+G N LG + N K E HS L Q G VY G
Sbjct: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG- 202
Query: 156 FRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLGCGE 213
HG G + G E + C P ++ G ++A+ DH VVLT G V+T G
Sbjct: 203 ----HGPGGRLGHGDE-QTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNI 257
Query: 214 QGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGL 273
QLG + S+ RQ A + R + AA R H + +A ++ GL
Sbjct: 258 FHQLGIIPPPSSCNVPRQ-IQAKYLKGRTIIGVAAGRF---HTVLWTREA----VYTMGL 309
Query: 274 NNYGQLGI----TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYA 329
N GQLG GEK TA P + AL D A S VA T+ + G IY
Sbjct: 310 NG-GQLGCLLDPNGEKCVTA---PRQVSALH--HKDIALSLVAASDGATVCVTTRGDIYL 363
Query: 330 L 330
L
Sbjct: 364 L 364
Score = 52.0 bits (119), Expect = 5e-06
Identities = 37/122 (30%), Positives = 56/122 (45%), Gaps = 5/122 (4%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
V L + H++ L+ GQ+Y G GRLG GD+ L+ L C +AA +
Sbjct: 182 VVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQ-TCLVPRLVEGLNGHNCSQVAAAKDH 240
Query: 371 SFAVTDSGEVYSWGMGSEGKLG-TGESEDLNEP---TLAAVDSRAPLRVSAGGQHTVLLV 426
+ +T+ G VY++G+ +LG N P + R + V+AG HTVL
Sbjct: 241 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT 300
Query: 427 EE 428
E
Sbjct: 301 RE 302
Score = 40.7 bits (91), Expect = 0.012
Identities = 23/69 (33%), Positives = 32/69 (46%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
++G+V TCG G G+LG G++ G V A HT+ L G ++TF
Sbjct: 194 QKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTF 253
Query: 102 GCNDEGALG 110
G N LG
Sbjct: 254 GLNIFHQLG 262
Score = 33.1 bits (72), Expect = 2.4
Identities = 37/139 (26%), Positives = 61/139 (43%), Gaps = 13/139 (9%)
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
H+ F+ +Q +++ G G+LG E+ T L P + L H S VA +
Sbjct: 188 HSVFL--SQKGQVYTCGHGPGGRLGHGDEQ--TCLV-PRLVEGLNG----HNCSQVAAAK 238
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPK--LQNKKCISIAAGTSNSFA 373
HT+ L +G +Y G + +LG+ I L+ + I +AAG ++
Sbjct: 239 DHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVL 298
Query: 374 VTDSGEVYSWGMGSEGKLG 392
T VY+ G+ G+LG
Sbjct: 299 WTREA-VYTMGLNG-GQLG 315
>BC113698-1|AAI13699.1| 1353|Homo sapiens inhibitor of Bruton
agammaglobulinemia tyrosine kinase protein.
Length = 1353
Score = 58.0 bits (134), Expect = 7e-08
Identities = 73/241 (30%), Positives = 96/241 (39%), Gaps = 28/241 (11%)
Query: 98 IWTFGCNDEGALGRATSNEKD--EGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGS 155
++T+G N LG + N K E HS L Q G VY G
Sbjct: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG- 202
Query: 156 FRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLGCGE 213
HG G + G E + C P ++ G ++A+ DH VVLT G V+T G
Sbjct: 203 ----HGPGGRLGHGDE-QTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNI 257
Query: 214 QGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGL 273
QLG + S+ RQ A + R + AA R H + +A ++ GL
Sbjct: 258 FHQLGIIPPPSSCNVPRQ-IQAKYLKGRTIIGVAAGRF---HTVLWTREA----VYTMGL 309
Query: 274 NNYGQLGI----TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYA 329
N GQLG GEK TA P + AL D A S VA T+ + G IY
Sbjct: 310 NG-GQLGCLLDPNGEKCVTA---PRQVSALH--HKDIALSLVAASDGATVCVTTRGDIYL 363
Query: 330 L 330
L
Sbjct: 364 L 364
Score = 52.0 bits (119), Expect = 5e-06
Identities = 37/122 (30%), Positives = 56/122 (45%), Gaps = 5/122 (4%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
V L + H++ L+ GQ+Y G GRLG GD+ L+ L C +AA +
Sbjct: 182 VVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQ-TCLVPRLVEGLNGHNCSQVAAAKDH 240
Query: 371 SFAVTDSGEVYSWGMGSEGKLG-TGESEDLNEP---TLAAVDSRAPLRVSAGGQHTVLLV 426
+ +T+ G VY++G+ +LG N P + R + V+AG HTVL
Sbjct: 241 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT 300
Query: 427 EE 428
E
Sbjct: 301 RE 302
Score = 40.7 bits (91), Expect = 0.012
Identities = 23/69 (33%), Positives = 32/69 (46%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
++G+V TCG G G+LG G++ G V A HT+ L G ++TF
Sbjct: 194 QKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTF 253
Query: 102 GCNDEGALG 110
G N LG
Sbjct: 254 GLNIFHQLG 262
Score = 33.1 bits (72), Expect = 2.4
Identities = 37/139 (26%), Positives = 61/139 (43%), Gaps = 13/139 (9%)
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
H+ F+ +Q +++ G G+LG E+ T L P + L H S VA +
Sbjct: 188 HSVFL--SQKGQVYTCGHGPGGRLGHGDEQ--TCLV-PRLVEGLNG----HNCSQVAAAK 238
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPK--LQNKKCISIAAGTSNSFA 373
HT+ L +G +Y G + +LG+ I L+ + I +AAG ++
Sbjct: 239 DHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVL 298
Query: 374 VTDSGEVYSWGMGSEGKLG 392
T VY+ G+ G+LG
Sbjct: 299 WTREA-VYTMGLNG-GQLG 315
>BC113696-1|AAI13697.1| 1353|Homo sapiens inhibitor of Bruton
agammaglobulinemia tyrosine kinase protein.
Length = 1353
Score = 58.0 bits (134), Expect = 7e-08
Identities = 73/241 (30%), Positives = 96/241 (39%), Gaps = 28/241 (11%)
Query: 98 IWTFGCNDEGALGRATSNEKD--EGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGS 155
++T+G N LG + N K E HS L Q G VY G
Sbjct: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG- 202
Query: 156 FRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLGCGE 213
HG G + G E + C P ++ G ++A+ DH VVLT G V+T G
Sbjct: 203 ----HGPGGRLGHGDE-QTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNI 257
Query: 214 QGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGL 273
QLG + S+ RQ A + R + AA R H + +A ++ GL
Sbjct: 258 FHQLGIIPPPSSCNVPRQ-IQAKYLKGRTIIGVAAGRF---HTVLWTREA----VYTMGL 309
Query: 274 NNYGQLGI----TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYA 329
N GQLG GEK TA P + AL D A S VA T+ + G IY
Sbjct: 310 NG-GQLGCLLDPNGEKCVTA---PRQVSALH--HKDIALSLVAASDGATVCVTTRGDIYL 363
Query: 330 L 330
L
Sbjct: 364 L 364
Score = 52.0 bits (119), Expect = 5e-06
Identities = 37/122 (30%), Positives = 56/122 (45%), Gaps = 5/122 (4%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
V L + H++ L+ GQ+Y G GRLG GD+ L+ L C +AA +
Sbjct: 182 VVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQ-TCLVPRLVEGLNGHNCSQVAAAKDH 240
Query: 371 SFAVTDSGEVYSWGMGSEGKLG-TGESEDLNEP---TLAAVDSRAPLRVSAGGQHTVLLV 426
+ +T+ G VY++G+ +LG N P + R + V+AG HTVL
Sbjct: 241 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT 300
Query: 427 EE 428
E
Sbjct: 301 RE 302
Score = 40.7 bits (91), Expect = 0.012
Identities = 23/69 (33%), Positives = 32/69 (46%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
++G+V TCG G G+LG G++ G V A HT+ L G ++TF
Sbjct: 194 QKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTF 253
Query: 102 GCNDEGALG 110
G N LG
Sbjct: 254 GLNIFHQLG 262
Score = 33.1 bits (72), Expect = 2.4
Identities = 37/139 (26%), Positives = 61/139 (43%), Gaps = 13/139 (9%)
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
H+ F+ +Q +++ G G+LG E+ T L P + L H S VA +
Sbjct: 188 HSVFL--SQKGQVYTCGHGPGGRLGHGDEQ--TCLV-PRLVEGLNG----HNCSQVAAAK 238
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPK--LQNKKCISIAAGTSNSFA 373
HT+ L +G +Y G + +LG+ I L+ + I +AAG ++
Sbjct: 239 DHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVL 298
Query: 374 VTDSGEVYSWGMGSEGKLG 392
T VY+ G+ G+LG
Sbjct: 299 WTREA-VYTMGLNG-GQLG 315
>AL050333-2|CAI23416.1| 1187|Homo sapiens RP1-93K22.1 protein.
Length = 1187
Score = 58.0 bits (134), Expect = 7e-08
Identities = 73/241 (30%), Positives = 96/241 (39%), Gaps = 28/241 (11%)
Query: 98 IWTFGCNDEGALGRATSNEKD--EGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGS 155
++T+G N LG + N K E HS L Q G VY G
Sbjct: 140 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG- 198
Query: 156 FRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLGCGE 213
HG G + G E + C P ++ G ++A+ DH VVLT G V+T G
Sbjct: 199 ----HGPGGRLGHGDE-QTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNI 253
Query: 214 QGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGL 273
QLG + S+ RQ A + R + AA R H + +A ++ GL
Sbjct: 254 FHQLGIIPPPSSCNVPRQ-IQAKYLKGRTIIGVAAGRF---HTVLWTREA----VYTMGL 305
Query: 274 NNYGQLGI----TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYA 329
N GQLG GEK TA P + AL D A S VA T+ + G IY
Sbjct: 306 NG-GQLGCLLDPNGEKCVTA---PRQVSALH--HKDIALSLVAASDGATVCVTTRGDIYL 359
Query: 330 L 330
L
Sbjct: 360 L 360
Score = 52.0 bits (119), Expect = 5e-06
Identities = 37/122 (30%), Positives = 56/122 (45%), Gaps = 5/122 (4%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
V L + H++ L+ GQ+Y G GRLG GD+ L+ L C +AA +
Sbjct: 178 VVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQ-TCLVPRLVEGLNGHNCSQVAAAKDH 236
Query: 371 SFAVTDSGEVYSWGMGSEGKLG-TGESEDLNEP---TLAAVDSRAPLRVSAGGQHTVLLV 426
+ +T+ G VY++G+ +LG N P + R + V+AG HTVL
Sbjct: 237 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT 296
Query: 427 EE 428
E
Sbjct: 297 RE 298
Score = 40.7 bits (91), Expect = 0.012
Identities = 23/69 (33%), Positives = 32/69 (46%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
++G+V TCG G G+LG G++ G V A HT+ L G ++TF
Sbjct: 190 QKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTF 249
Query: 102 GCNDEGALG 110
G N LG
Sbjct: 250 GLNIFHQLG 258
Score = 33.1 bits (72), Expect = 2.4
Identities = 37/139 (26%), Positives = 61/139 (43%), Gaps = 13/139 (9%)
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
H+ F+ +Q +++ G G+LG E+ T L P + L H S VA +
Sbjct: 184 HSVFL--SQKGQVYTCGHGPGGRLGHGDEQ--TCLV-PRLVEGLNG----HNCSQVAAAK 234
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPK--LQNKKCISIAAGTSNSFA 373
HT+ L +G +Y G + +LG+ I L+ + I +AAG ++
Sbjct: 235 DHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVL 294
Query: 374 VTDSGEVYSWGMGSEGKLG 392
T VY+ G+ G+LG
Sbjct: 295 WTREA-VYTMGLNG-GQLG 311
>AB037838-1|BAA92655.2| 1379|Homo sapiens KIAA1417 protein protein.
Length = 1379
Score = 58.0 bits (134), Expect = 7e-08
Identities = 73/241 (30%), Positives = 96/241 (39%), Gaps = 28/241 (11%)
Query: 98 IWTFGCNDEGALGRATSNEKD--EGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGS 155
++T+G N LG + N K E HS L Q G VY G
Sbjct: 170 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG- 228
Query: 156 FRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLGCGE 213
HG G + G E + C P ++ G ++A+ DH VVLT G V+T G
Sbjct: 229 ----HGPGGRLGHGDE-QTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNI 283
Query: 214 QGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFVLDAQHARLFAFGL 273
QLG + S+ RQ A + R + AA R H + +A ++ GL
Sbjct: 284 FHQLGIIPPPSSCNVPRQ-IQAKYLKGRTIIGVAAGRF---HTVLWTREA----VYTMGL 335
Query: 274 NNYGQLGI----TGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYA 329
N GQLG GEK TA P + AL D A S VA T+ + G IY
Sbjct: 336 NG-GQLGCLLDPNGEKCVTA---PRQVSALH--HKDIALSLVAASDGATVCVTTRGDIYL 389
Query: 330 L 330
L
Sbjct: 390 L 390
Score = 52.0 bits (119), Expect = 5e-06
Identities = 37/122 (30%), Positives = 56/122 (45%), Gaps = 5/122 (4%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
V L + H++ L+ GQ+Y G GRLG GD+ L+ L C +AA +
Sbjct: 208 VVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQ-TCLVPRLVEGLNGHNCSQVAAAKDH 266
Query: 371 SFAVTDSGEVYSWGMGSEGKLG-TGESEDLNEP---TLAAVDSRAPLRVSAGGQHTVLLV 426
+ +T+ G VY++G+ +LG N P + R + V+AG HTVL
Sbjct: 267 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT 326
Query: 427 EE 428
E
Sbjct: 327 RE 328
Score = 40.7 bits (91), Expect = 0.012
Identities = 23/69 (33%), Positives = 32/69 (46%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
++G+V TCG G G+LG G++ G V A HT+ L G ++TF
Sbjct: 220 QKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTF 279
Query: 102 GCNDEGALG 110
G N LG
Sbjct: 280 GLNIFHQLG 288
Score = 33.1 bits (72), Expect = 2.4
Identities = 37/139 (26%), Positives = 61/139 (43%), Gaps = 13/139 (9%)
Query: 256 HATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQ 315
H+ F+ +Q +++ G G+LG E+ T L P + L H S VA +
Sbjct: 214 HSVFL--SQKGQVYTCGHGPGGRLGHGDEQ--TCLV-PRLVEGLNG----HNCSQVAAAK 264
Query: 316 HHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPK--LQNKKCISIAAGTSNSFA 373
HT+ L +G +Y G + +LG+ I L+ + I +AAG ++
Sbjct: 265 DHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVL 324
Query: 374 VTDSGEVYSWGMGSEGKLG 392
T VY+ G+ G+LG
Sbjct: 325 WTREA-VYTMGLNG-GQLG 341
>BC040695-1|AAH40695.1| 358|Homo sapiens WBSCR16 protein protein.
Length = 358
Score = 56.0 bits (129), Expect = 3e-07
Identities = 45/176 (25%), Positives = 78/176 (44%), Gaps = 10/176 (5%)
Query: 238 VPARVTLRQAAARVWAGHHATFVLD--AQHARLFAFGLNNYGQLGI-TGEKRKTA----L 290
VP R+ L Q + G+ T + A +++ GLN QLG K KT +
Sbjct: 99 VPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYV 158
Query: 291 FSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET- 349
P+ + V+ G+ H+L L ++++G YG+ G + +
Sbjct: 159 LEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSE 218
Query: 350 LELIPKLQN--KKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT 403
+ ++Q+ + + +A G +S +TD GEVYS G G++G+ G G + PT
Sbjct: 219 SHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPT 274
Score = 54.4 bits (125), Expect = 9e-07
Identities = 61/235 (25%), Positives = 102/235 (43%), Gaps = 16/235 (6%)
Query: 206 VFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTL---RQAAARVW---AGHHATF 259
V+ +G + QLG R +D +G+ +L P+ V+L R RV G +
Sbjct: 131 VWGMGLNKDSQLGFHRSR---KDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSL 187
Query: 260 VLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGD-DHAWSAVALGQHHT 318
VL + +F+ G N+YGQ G + + ++S E + + D D VA GQ H+
Sbjct: 188 VLTDREG-VFSMGNNSYGQCG--RKVVENEIYS--ESHRVHRMQDFDGQVVQVACGQDHS 242
Query: 319 LTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSG 378
L L G++Y+ G G+ GLG + + +L L I +A AV+ G
Sbjct: 243 LFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADG 302
Query: 379 EVYSWGMGSEGKLGT-GESEDLNEPTLAAVDSRAPLRVSAGGQHTVLLVEETSSQ 432
++ WG +L + +S +N P +R +A G ++ +T Q
Sbjct: 303 GLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNDTWPQ 357
Score = 41.9 bits (94), Expect = 0.005
Identities = 36/144 (25%), Positives = 57/144 (39%), Gaps = 7/144 (4%)
Query: 78 KIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGR-ATSNE---KDEGTPKQXXXXXXXXX 133
+++ V G H++ L +++ G N G GR NE + +
Sbjct: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234
Query: 134 XXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASG 193
G HS L G+VY+ G D G GL P K + G +++A+
Sbjct: 235 VACGQDHSLFLTDKGEVYSCGWGAD--GQTGLGHYNITSSPTKLGGDL-AGVNVIQVATY 291
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQL 217
GD + ++ GG+F G E QL
Sbjct: 292 GDCCLAVSADGGLFGWGNSEYLQL 315
Score = 37.9 bits (84), Expect = 0.083
Identities = 26/84 (30%), Positives = 39/84 (46%), Gaps = 4/84 (4%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGRE--GKPCKEPVKIDIGEPAVEIASGG 194
G +HS L V++ G+ +S+G G V E + + D V++A G
Sbjct: 182 GRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQ 239
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLG 218
DH + LT G V++ G G GQ G
Sbjct: 240 DHSLFLTDKGEVYSCGWGADGQTG 263
Score = 33.1 bits (72), Expect = 2.4
Identities = 25/78 (32%), Positives = 36/78 (46%), Gaps = 8/78 (10%)
Query: 150 VYAWGSFRDS----HGSMGLVVRGREGKPCKEPVKIDIGEP----AVEIASGGDHLVVLT 201
V+ G +DS H S RG E PV + + P ++++ G H +VLT
Sbjct: 131 VWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLT 190
Query: 202 TSGGVFTLGCGEQGQLGR 219
GVF++G GQ GR
Sbjct: 191 DREGVFSMGNNSYGQCGR 208
Score = 31.1 bits (67), Expect = 9.5
Identities = 20/74 (27%), Positives = 36/74 (48%), Gaps = 1/74 (1%)
Query: 43 RGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTF 101
+G V +CG G GQ GLG + ++ K L G ++ V G +A+ + G ++ +
Sbjct: 248 KGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGW 307
Query: 102 GCNDEGALGRATSN 115
G ++ L T +
Sbjct: 308 GNSEYLQLASVTDS 321
>BC032712-1|AAH32712.1| 454|Homo sapiens WBSCR16 protein protein.
Length = 454
Score = 56.0 bits (129), Expect = 3e-07
Identities = 45/176 (25%), Positives = 78/176 (44%), Gaps = 10/176 (5%)
Query: 238 VPARVTLRQAAARVWAGHHATFVLD--AQHARLFAFGLNNYGQLGI-TGEKRKTA----L 290
VP R+ L Q + G+ T + A +++ GLN QLG K KT +
Sbjct: 99 VPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYV 158
Query: 291 FSPTECDALRAVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET- 349
P+ + V+ G+ H+L L ++++G YG+ G + +
Sbjct: 159 LEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSE 218
Query: 350 LELIPKLQN--KKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT 403
+ ++Q+ + + +A G +S +TD GEVYS G G++G+ G G + PT
Sbjct: 219 SHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPT 274
Score = 54.4 bits (125), Expect = 9e-07
Identities = 75/283 (26%), Positives = 109/283 (38%), Gaps = 30/283 (10%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGRE--GKPCKEPVKIDIGEPAVEIASGG 194
G +HS L V++ G+ +S+G G V E + + D V++A G
Sbjct: 182 GRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQ 239
Query: 195 DHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWAG 254
DH + LT G V++ G G GQ G S + G A V + Q A G
Sbjct: 240 DHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDL----AGVNVIQVATY---G 292
Query: 255 HHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALG 314
V + LF +G + Y QL + + + C VG A G
Sbjct: 293 DCCLAV--SADGGLFGWGNSEYLQLASVTDSTQVNV---PRCLHFSGVGKVRQ---AACG 344
Query: 315 QHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIP-------KLQNKKCIS-IAA 366
L G ++ G YG LG G ++ E+IP + + +S I
Sbjct: 345 GTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRC 401
Query: 367 GTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDS 409
G S+ A+T+ GE++ WG G LG G ED P A S
Sbjct: 402 GLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRAPAPS 444
Score = 53.6 bits (123), Expect = 2e-06
Identities = 59/222 (26%), Positives = 97/222 (43%), Gaps = 16/222 (7%)
Query: 206 VFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTL---RQAAARVW---AGHHATF 259
V+ +G + QLG R +D +G+ +L P+ V+L R RV G +
Sbjct: 131 VWGMGLNKDSQLGFHRSR---KDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSL 187
Query: 260 VLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGD-DHAWSAVALGQHHT 318
VL + +F+ G N+YGQ G + + ++S E + + D D VA GQ H+
Sbjct: 188 VLTDREG-VFSMGNNSYGQCG--RKVVENEIYS--ESHRVHRMQDFDGQVVQVACGQDHS 242
Query: 319 LTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSG 378
L L G++Y+ G G+ GLG + + +L L I +A AV+ G
Sbjct: 243 LFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADG 302
Query: 379 EVYSWGMGSEGKLGT-GESEDLNEPTLAAVDSRAPLRVSAGG 419
++ WG +L + +S +N P +R +A G
Sbjct: 303 GLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344
Score = 48.4 bits (110), Expect = 6e-05
Identities = 62/268 (23%), Positives = 99/268 (36%), Gaps = 17/268 (6%)
Query: 78 KIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGR-ATSNE---KDEGTPKQXXXXXXXXX 133
+++ V G H++ L +++ G N G GR NE + +
Sbjct: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234
Query: 134 XXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASG 193
G HS L G+VY+ G D G GL P K + G +++A+
Sbjct: 235 VACGQDHSLFLTDKGEVYSCGWGAD--GQTGLGHYNITSSPTKLGGDL-AGVNVIQVATY 291
Query: 194 GDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLVPARVTLRQAAARVWA 253
GD + ++ GG+F G E QL + + R L +RQAA
Sbjct: 292 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR----CLHFSGVGKVRQAA----C 343
Query: 254 GHHATFVLDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVAL 313
G VL+ + +F +G G+ E + PT L + S +
Sbjct: 344 GGTGCAVLNGE-GHVFVWGYGILGKGPNLVESAVPEMIPPT-LFGLTEFNPEIQVSRIRC 401
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLG 341
G H L G+++ G+ G LG+G
Sbjct: 402 GLSHFAALTNKGELFVWGKNIRGCLGIG 429
Score = 40.3 bits (90), Expect = 0.016
Identities = 60/252 (23%), Positives = 99/252 (39%), Gaps = 26/252 (10%)
Query: 150 VYAWGSFRDS----HGSMGLVVRGREGKPCKEPVKIDIGEP----AVEIASGGDHLVVLT 201
V+ G +DS H S RG E PV + + P ++++ G H +VLT
Sbjct: 131 VWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLT 190
Query: 202 TSGGVFTLGCGEQGQLGR-LAQRSASRDARQGFSALLVPARVTLRQAAARVWAGHHATFV 260
GVF++G GQ GR + + ++ + +V Q A H+ F+
Sbjct: 191 DREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVV--QVAC---GQDHSLFL 245
Query: 261 LDAQHARLFAFGLNNYGQLGITGEKRKTALFSPTECDALRAVGDDHAWSAVALGQHH--T 318
D +++ G GQ G+ G T+ SPT+ GD + + + +
Sbjct: 246 TD--KGEVYSCGWGADGQTGL-GHYNITS--SPTKLG-----GDLAGVNVIQVATYGDCC 295
Query: 319 LTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSG 378
L ++A+G ++ G EY +L S + K A G + + G
Sbjct: 296 LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEG 355
Query: 379 EVYSWGMGSEGK 390
V+ WG G GK
Sbjct: 356 HVFVWGYGILGK 367
Score = 36.3 bits (80), Expect = 0.25
Identities = 44/183 (24%), Positives = 71/183 (38%), Gaps = 10/183 (5%)
Query: 43 RGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTF 101
+G V +CG G GQ GLG + ++ K L G ++ V G +A+ + G ++ +
Sbjct: 248 KGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGW 307
Query: 102 GCNDEGALGRAT-SNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDSH 160
G ++ L T S + + G + A L G V+ WG
Sbjct: 308 GNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 367
Query: 161 GSMGLVVRGREGKPCKEPVKIDIGE--PAVEIA---SGGDHLVVLTTSGGVFTLGCGEQG 215
G + E P P + E P ++++ G H LT G +F G +G
Sbjct: 368 GPNLVESAVPEMIP---PTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRG 424
Query: 216 QLG 218
LG
Sbjct: 425 CLG 427
>AL359257-2|CAI39759.1| 4640|Homo sapiens AC001226.5 protein.
Length = 4640
Score = 53.2 bits (122), Expect = 2e-06
Identities = 32/83 (38%), Positives = 43/83 (51%), Gaps = 5/83 (6%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDH 196
G HS L++NGDVY +G HG +G G C V+ G P+ ++ +G +H
Sbjct: 910 GFHHSVVLMENGDVYTFGY--GQHGQLGHGDVNSRG--CPTLVQALPG-PSTQVTAGSNH 964
Query: 197 LVVLTTSGGVFTLGCGEQGQLGR 219
VL G VFT G +GQLGR
Sbjct: 965 TAVLLMDGQVFTFGSFSKGQLGR 987
Score = 51.6 bits (118), Expect = 6e-06
Identities = 38/122 (31%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 78 KIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXG 137
+ V V G H++ L +G ++TFG G LG N + T Q G
Sbjct: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQ-ALPGPSTQVTAG 961
Query: 138 DSHSAALLQNGDVYAWGSFRDSHGSMG---LVVRGREGKPCKEP-VKIDIGEPAVEIASG 193
+H+A LL +G V+ +GSF S G +G L V KP P + G A I +
Sbjct: 962 SNHTAVLLMDGQVFTFGSF--SKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGAS 1019
Query: 194 GD 195
GD
Sbjct: 1020 GD 1021
Score = 49.2 bits (112), Expect = 3e-05
Identities = 32/125 (25%), Positives = 60/125 (48%), Gaps = 9/125 (7%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
V+ G HH++ L NG +Y G ++G+LG GD + L+ L + AG+++
Sbjct: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRG-CPTLVQALPGPS-TQVTAGSNH 964
Query: 371 SFAVTDSGEVYSWGMGSEGKLGT-------GESEDLNEPTLAAVDSRAPLRVSAGGQHTV 423
+ + G+V+++G S+G+LG ++ P + + R + A G T
Sbjct: 965 TAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGASGDQTF 1024
Query: 424 LLVEE 428
L ++E
Sbjct: 1025 LRIDE 1029
Score = 46.8 bits (106), Expect = 2e-04
Identities = 20/67 (29%), Positives = 37/67 (55%)
Query: 360 KCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGG 419
+ + ++ G +S + ++G+VY++G G G+LG G+ PTL +V+AG
Sbjct: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGS 962
Query: 420 QHTVLLV 426
HT +L+
Sbjct: 963 NHTAVLL 969
Score = 44.0 bits (99), Expect = 0.001
Identities = 36/102 (35%), Positives = 49/102 (48%), Gaps = 11/102 (10%)
Query: 179 VKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLV 238
V+ D AV+++ G H VVL +G V+T G G+ GQLG D LV
Sbjct: 896 VRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGH-------GDVNSRGCPTLV 948
Query: 239 PARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLG 280
A L + +V AG + T VL ++F FG + GQLG
Sbjct: 949 QA---LPGPSTQVTAGSNHTAVL-LMDGQVFTFGSFSKGQLG 986
Score = 44.0 bits (99), Expect = 0.001
Identities = 29/70 (41%), Positives = 34/70 (48%), Gaps = 1/70 (1%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+ G V T G G GQLG G DV V AL V AG HT L G+++TF
Sbjct: 919 ENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTF 977
Query: 102 GCNDEGALGR 111
G +G LGR
Sbjct: 978 GSFSKGQLGR 987
Score = 43.6 bits (98), Expect = 0.002
Identities = 21/55 (38%), Positives = 30/55 (54%), Gaps = 1/55 (1%)
Query: 60 GEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRAT 113
G+D + + VT L G + V G HT L +G++WTFG N++G GR T
Sbjct: 625 GKDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDT 679
Score = 36.7 bits (81), Expect = 0.19
Identities = 25/94 (26%), Positives = 42/94 (44%), Gaps = 4/94 (4%)
Query: 301 AVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKK 360
+ G D + + G+ L ANG+IY G+ Y LG+ A +P ++ K
Sbjct: 486 STGFDEESAILGAGREFALMKTANGKIYYTGK--YQSLGIKQGGPSAGKWVELPITKSPK 543
Query: 361 CISIAAGTSNSFA--VTDSGEVYSWGMGSEGKLG 392
+ + G S A V + G ++ G S+G+ G
Sbjct: 544 IVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDG 577
>AL159158-1|CAI16842.1| 4640|Homo sapiens AC001226.5 protein.
Length = 4640
Score = 53.2 bits (122), Expect = 2e-06
Identities = 32/83 (38%), Positives = 43/83 (51%), Gaps = 5/83 (6%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDH 196
G HS L++NGDVY +G HG +G G C V+ G P+ ++ +G +H
Sbjct: 910 GFHHSVVLMENGDVYTFGY--GQHGQLGHGDVNSRG--CPTLVQALPG-PSTQVTAGSNH 964
Query: 197 LVVLTTSGGVFTLGCGEQGQLGR 219
VL G VFT G +GQLGR
Sbjct: 965 TAVLLMDGQVFTFGSFSKGQLGR 987
Score = 51.6 bits (118), Expect = 6e-06
Identities = 38/122 (31%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 78 KIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXG 137
+ V V G H++ L +G ++TFG G LG N + T Q G
Sbjct: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQ-ALPGPSTQVTAG 961
Query: 138 DSHSAALLQNGDVYAWGSFRDSHGSMG---LVVRGREGKPCKEP-VKIDIGEPAVEIASG 193
+H+A LL +G V+ +GSF S G +G L V KP P + G A I +
Sbjct: 962 SNHTAVLLMDGQVFTFGSF--SKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGAS 1019
Query: 194 GD 195
GD
Sbjct: 1020 GD 1021
Score = 49.2 bits (112), Expect = 3e-05
Identities = 32/125 (25%), Positives = 60/125 (48%), Gaps = 9/125 (7%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
V+ G HH++ L NG +Y G ++G+LG GD + L+ L + AG+++
Sbjct: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRG-CPTLVQALPGPS-TQVTAGSNH 964
Query: 371 SFAVTDSGEVYSWGMGSEGKLGT-------GESEDLNEPTLAAVDSRAPLRVSAGGQHTV 423
+ + G+V+++G S+G+LG ++ P + + R + A G T
Sbjct: 965 TAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGASGDQTF 1024
Query: 424 LLVEE 428
L ++E
Sbjct: 1025 LRIDE 1029
Score = 46.8 bits (106), Expect = 2e-04
Identities = 20/67 (29%), Positives = 37/67 (55%)
Query: 360 KCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGG 419
+ + ++ G +S + ++G+VY++G G G+LG G+ PTL +V+AG
Sbjct: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGS 962
Query: 420 QHTVLLV 426
HT +L+
Sbjct: 963 NHTAVLL 969
Score = 44.0 bits (99), Expect = 0.001
Identities = 36/102 (35%), Positives = 49/102 (48%), Gaps = 11/102 (10%)
Query: 179 VKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLV 238
V+ D AV+++ G H VVL +G V+T G G+ GQLG D LV
Sbjct: 896 VRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGH-------GDVNSRGCPTLV 948
Query: 239 PARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLG 280
A L + +V AG + T VL ++F FG + GQLG
Sbjct: 949 QA---LPGPSTQVTAGSNHTAVL-LMDGQVFTFGSFSKGQLG 986
Score = 44.0 bits (99), Expect = 0.001
Identities = 29/70 (41%), Positives = 34/70 (48%), Gaps = 1/70 (1%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+ G V T G G GQLG G DV V AL V AG HT L G+++TF
Sbjct: 919 ENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTF 977
Query: 102 GCNDEGALGR 111
G +G LGR
Sbjct: 978 GSFSKGQLGR 987
Score = 43.6 bits (98), Expect = 0.002
Identities = 21/55 (38%), Positives = 30/55 (54%), Gaps = 1/55 (1%)
Query: 60 GEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRAT 113
G+D + + VT L G + V G HT L +G++WTFG N++G GR T
Sbjct: 625 GKDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDT 679
Score = 36.7 bits (81), Expect = 0.19
Identities = 25/94 (26%), Positives = 42/94 (44%), Gaps = 4/94 (4%)
Query: 301 AVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKK 360
+ G D + + G+ L ANG+IY G+ Y LG+ A +P ++ K
Sbjct: 486 STGFDEESAILGAGREFALMKTANGKIYYTGK--YQSLGIKQGGPSAGKWVELPITKSPK 543
Query: 361 CISIAAGTSNSFA--VTDSGEVYSWGMGSEGKLG 392
+ + G S A V + G ++ G S+G+ G
Sbjct: 544 IVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDG 577
>AL159154-1|CAH73736.1| 4640|Homo sapiens AC001226.5 protein.
Length = 4640
Score = 53.2 bits (122), Expect = 2e-06
Identities = 32/83 (38%), Positives = 43/83 (51%), Gaps = 5/83 (6%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDH 196
G HS L++NGDVY +G HG +G G C V+ G P+ ++ +G +H
Sbjct: 910 GFHHSVVLMENGDVYTFGY--GQHGQLGHGDVNSRG--CPTLVQALPG-PSTQVTAGSNH 964
Query: 197 LVVLTTSGGVFTLGCGEQGQLGR 219
VL G VFT G +GQLGR
Sbjct: 965 TAVLLMDGQVFTFGSFSKGQLGR 987
Score = 51.6 bits (118), Expect = 6e-06
Identities = 38/122 (31%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 78 KIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXG 137
+ V V G H++ L +G ++TFG G LG N + T Q G
Sbjct: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQ-ALPGPSTQVTAG 961
Query: 138 DSHSAALLQNGDVYAWGSFRDSHGSMG---LVVRGREGKPCKEP-VKIDIGEPAVEIASG 193
+H+A LL +G V+ +GSF S G +G L V KP P + G A I +
Sbjct: 962 SNHTAVLLMDGQVFTFGSF--SKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGAS 1019
Query: 194 GD 195
GD
Sbjct: 1020 GD 1021
Score = 49.2 bits (112), Expect = 3e-05
Identities = 32/125 (25%), Positives = 60/125 (48%), Gaps = 9/125 (7%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
V+ G HH++ L NG +Y G ++G+LG GD + L+ L + AG+++
Sbjct: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRG-CPTLVQALPGPS-TQVTAGSNH 964
Query: 371 SFAVTDSGEVYSWGMGSEGKLGT-------GESEDLNEPTLAAVDSRAPLRVSAGGQHTV 423
+ + G+V+++G S+G+LG ++ P + + R + A G T
Sbjct: 965 TAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGASGDQTF 1024
Query: 424 LLVEE 428
L ++E
Sbjct: 1025 LRIDE 1029
Score = 46.8 bits (106), Expect = 2e-04
Identities = 20/67 (29%), Positives = 37/67 (55%)
Query: 360 KCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGG 419
+ + ++ G +S + ++G+VY++G G G+LG G+ PTL +V+AG
Sbjct: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGS 962
Query: 420 QHTVLLV 426
HT +L+
Sbjct: 963 NHTAVLL 969
Score = 44.0 bits (99), Expect = 0.001
Identities = 36/102 (35%), Positives = 49/102 (48%), Gaps = 11/102 (10%)
Query: 179 VKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLV 238
V+ D AV+++ G H VVL +G V+T G G+ GQLG D LV
Sbjct: 896 VRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGH-------GDVNSRGCPTLV 948
Query: 239 PARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLG 280
A L + +V AG + T VL ++F FG + GQLG
Sbjct: 949 QA---LPGPSTQVTAGSNHTAVL-LMDGQVFTFGSFSKGQLG 986
Score = 44.0 bits (99), Expect = 0.001
Identities = 29/70 (41%), Positives = 34/70 (48%), Gaps = 1/70 (1%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+ G V T G G GQLG G DV V AL V AG HT L G+++TF
Sbjct: 919 ENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTF 977
Query: 102 GCNDEGALGR 111
G +G LGR
Sbjct: 978 GSFSKGQLGR 987
Score = 43.6 bits (98), Expect = 0.002
Identities = 21/55 (38%), Positives = 30/55 (54%), Gaps = 1/55 (1%)
Query: 60 GEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRAT 113
G+D + + VT L G + V G HT L +G++WTFG N++G GR T
Sbjct: 625 GKDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDT 679
Score = 36.7 bits (81), Expect = 0.19
Identities = 25/94 (26%), Positives = 42/94 (44%), Gaps = 4/94 (4%)
Query: 301 AVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKK 360
+ G D + + G+ L ANG+IY G+ Y LG+ A +P ++ K
Sbjct: 486 STGFDEESAILGAGREFALMKTANGKIYYTGK--YQSLGIKQGGPSAGKWVELPITKSPK 543
Query: 361 CISIAAGTSNSFA--VTDSGEVYSWGMGSEGKLG 392
+ + G S A V + G ++ G S+G+ G
Sbjct: 544 IVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDG 577
>AF075587-1|AAC39928.1| 4641|Homo sapiens protein associated with
Myc protein.
Length = 4641
Score = 53.2 bits (122), Expect = 2e-06
Identities = 32/83 (38%), Positives = 43/83 (51%), Gaps = 5/83 (6%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDH 196
G HS L++NGDVY +G HG +G G C V+ G P+ ++ +G +H
Sbjct: 910 GFHHSVVLMENGDVYTFGY--GQHGQLGHGDVNSRG--CPTLVQALPG-PSTQVTAGSNH 964
Query: 197 LVVLTTSGGVFTLGCGEQGQLGR 219
VL G VFT G +GQLGR
Sbjct: 965 TAVLLMDGQVFTFGSFSKGQLGR 987
Score = 51.6 bits (118), Expect = 6e-06
Identities = 38/122 (31%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 78 KIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXG 137
+ V V G H++ L +G ++TFG G LG N + T Q G
Sbjct: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQ-ALPGPSTQVTAG 961
Query: 138 DSHSAALLQNGDVYAWGSFRDSHGSMG---LVVRGREGKPCKEP-VKIDIGEPAVEIASG 193
+H+A LL +G V+ +GSF S G +G L V KP P + G A I +
Sbjct: 962 SNHTAVLLMDGQVFTFGSF--SKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGAS 1019
Query: 194 GD 195
GD
Sbjct: 1020 GD 1021
Score = 49.2 bits (112), Expect = 3e-05
Identities = 32/125 (25%), Positives = 60/125 (48%), Gaps = 9/125 (7%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSN 370
V+ G HH++ L NG +Y G ++G+LG GD + L+ L + AG+++
Sbjct: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRG-CPTLVQALPGPS-TQVTAGSNH 964
Query: 371 SFAVTDSGEVYSWGMGSEGKLGT-------GESEDLNEPTLAAVDSRAPLRVSAGGQHTV 423
+ + G+V+++G S+G+LG ++ P + + R + A G T
Sbjct: 965 TAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGASGDQTF 1024
Query: 424 LLVEE 428
L ++E
Sbjct: 1025 LRIDE 1029
Score = 46.8 bits (106), Expect = 2e-04
Identities = 20/67 (29%), Positives = 37/67 (55%)
Query: 360 KCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGG 419
+ + ++ G +S + ++G+VY++G G G+LG G+ PTL +V+AG
Sbjct: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGS 962
Query: 420 QHTVLLV 426
HT +L+
Sbjct: 963 NHTAVLL 969
Score = 44.0 bits (99), Expect = 0.001
Identities = 36/102 (35%), Positives = 49/102 (48%), Gaps = 11/102 (10%)
Query: 179 VKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGRLAQRSASRDARQGFSALLV 238
V+ D AV+++ G H VVL +G V+T G G+ GQLG D LV
Sbjct: 896 VRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGH-------GDVNSRGCPTLV 948
Query: 239 PARVTLRQAAARVWAGHHATFVLDAQHARLFAFGLNNYGQLG 280
A L + +V AG + T VL ++F FG + GQLG
Sbjct: 949 QA---LPGPSTQVTAGSNHTAVL-LMDGQVFTFGSFSKGQLG 986
Score = 44.0 bits (99), Expect = 0.001
Identities = 29/70 (41%), Positives = 34/70 (48%), Gaps = 1/70 (1%)
Query: 42 KRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+ G V T G G GQLG G DV V AL V AG HT L G+++TF
Sbjct: 919 ENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTF 977
Query: 102 GCNDEGALGR 111
G +G LGR
Sbjct: 978 GSFSKGQLGR 987
Score = 43.6 bits (98), Expect = 0.002
Identities = 21/55 (38%), Positives = 30/55 (54%), Gaps = 1/55 (1%)
Query: 60 GEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRAT 113
G+D + + VT L G + V G HT L +G++WTFG N++G GR T
Sbjct: 625 GKDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDT 679
Score = 36.7 bits (81), Expect = 0.19
Identities = 25/94 (26%), Positives = 42/94 (44%), Gaps = 4/94 (4%)
Query: 301 AVGDDHAWSAVALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKK 360
+ G D + + G+ L ANG+IY G+ Y LG+ A +P ++ K
Sbjct: 486 STGFDEESAILGAGREFALMKTANGKIYYTGK--YQSLGIKQGGPSAGKWVELPITKSPK 543
Query: 361 CISIAAGTSNSFA--VTDSGEVYSWGMGSEGKLG 392
+ + G S A V + G ++ G S+G+ G
Sbjct: 544 IVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDG 577
>BC071576-1|AAH71576.1| 1237|Homo sapiens ALS2 protein protein.
Length = 1237
Score = 52.8 bits (121), Expect = 3e-06
Identities = 38/126 (30%), Positives = 62/126 (49%), Gaps = 19/126 (15%)
Query: 312 ALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQN----KKCISIAAG 367
ALG H + L +G++Y+ G + +SG E P L+N + I++A G
Sbjct: 47 ALGVKHGVLLTEDGEVYSFGTLPW-------RSGPVEICPSSPILENALVGQYVITVATG 99
Query: 368 TSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT-LAAVDSRAP-------LRVSAGG 419
+ +S AVTD+G Y WG S G+ + + EP ++ DS A L+++ G
Sbjct: 100 SFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGE 159
Query: 420 QHTVLL 425
+HT+ L
Sbjct: 160 EHTLAL 165
Score = 50.0 bits (114), Expect = 2e-05
Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFA 373
G+ L + +++ G+ + G+LG GD + L + L K+ I + AG +S A
Sbjct: 515 GEADALLPSLRIEVWTWGKGKEGQLGHGDVLPRLQPL-CVKCLDGKEVIHLEAGGYHSLA 573
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL-RVSAGGQHTVLLVEETSSQ 432
+T +VYSWG + G+LG + P LA + S + ++AG +++ LV+ Q
Sbjct: 574 LTAKSQVYSWGSNTFGQLGHSDF-PTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQ 632
Score = 48.4 bits (110), Expect = 6e-05
Identities = 27/74 (36%), Positives = 44/74 (59%), Gaps = 2/74 (2%)
Query: 40 PKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKI 98
P R V T G+G GQLG G DV+ + V L G +++ ++AGG H++AL + ++
Sbjct: 522 PSLRIEVWTWGKGKEGQLGHG-DVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQV 580
Query: 99 WTFGCNDEGALGRA 112
+++G N G LG +
Sbjct: 581 YSWGSNTFGQLGHS 594
Score = 39.9 bits (89), Expect = 0.021
Identities = 34/136 (25%), Positives = 60/136 (44%), Gaps = 9/136 (6%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET-------LELIPKLQNKKCIS 363
VA G H+ + NG Y G G+ + ++ E E P L + +
Sbjct: 96 VATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLA-VRILQ 154
Query: 364 IAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTV 423
+A G ++ A++ S E+++WG G + L T + + R L+V+ G H++
Sbjct: 155 LACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSL 214
Query: 424 LLVEETSSQREPSPIP 439
LV+ SQ + P+P
Sbjct: 215 ALVQCLPSQ-DLKPVP 229
Score = 34.3 bits (75), Expect = 1.0
Identities = 35/148 (23%), Positives = 58/148 (39%), Gaps = 17/148 (11%)
Query: 76 GDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTP--KQXXXXXXXXX 133
G ++ G H + L G++++FG R+ E +P +
Sbjct: 40 GKTVLQAALGVKHGVLLTEDGEVYSFGTLP----WRSGPVEICPSSPILENALVGQYVIT 95
Query: 134 XXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPA------ 187
G HS A+ NG Y WG +S G V ++ P PV I E +
Sbjct: 96 VATGSFHSGAVTDNGVAYMWG--ENSAGQ--CAVANQQYVPEPNPVSIADSEASPLLAVR 151
Query: 188 -VEIASGGDHLVVLTTSGGVFTLGCGEQ 214
+++A G +H + L+ S ++ G G Q
Sbjct: 152 ILQLACGEEHTLALSISREIWAWGTGCQ 179
Score = 33.1 bits (72), Expect = 2.4
Identities = 19/68 (27%), Positives = 29/68 (42%), Gaps = 2/68 (2%)
Query: 97 KIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSF 156
++WT+G EG LG + + + G HS AL VY+WGS
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGS- 585
Query: 157 RDSHGSMG 164
++ G +G
Sbjct: 586 -NTFGQLG 592
Score = 31.1 bits (67), Expect = 9.5
Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 4/70 (5%)
Query: 149 DVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFT 208
+V+ WG ++ G V+ R C VK G+ + + +GG H + LT V++
Sbjct: 527 EVWTWGKGKEGQLGHGDVLP-RLQPLC---VKCLDGKEVIHLEAGGYHSLALTAKSQVYS 582
Query: 209 LGCGEQGQLG 218
G GQLG
Sbjct: 583 WGSNTFGQLG 592
>AB053306-1|BAB69015.1| 396|Homo sapiens ALS2 protein.
Length = 396
Score = 52.8 bits (121), Expect = 3e-06
Identities = 38/126 (30%), Positives = 62/126 (49%), Gaps = 19/126 (15%)
Query: 312 ALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQN----KKCISIAAG 367
ALG H + L +G++Y+ G + +SG E P L+N + I++A G
Sbjct: 47 ALGVKHGVLLTEDGEVYSFGTLPW-------RSGPVEICPSSPILENALVGQYVITVATG 99
Query: 368 TSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT-LAAVDSRAP-------LRVSAGG 419
+ +S AVTD+G Y WG S G+ + + EP ++ DS A L+++ G
Sbjct: 100 SFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGE 159
Query: 420 QHTVLL 425
+HT+ L
Sbjct: 160 EHTLAL 165
Score = 39.9 bits (89), Expect = 0.021
Identities = 34/136 (25%), Positives = 60/136 (44%), Gaps = 9/136 (6%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET-------LELIPKLQNKKCIS 363
VA G H+ + NG Y G G+ + ++ E E P L + +
Sbjct: 96 VATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLA-VRILQ 154
Query: 364 IAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTV 423
+A G ++ A++ S E+++WG G + L T + + R L+V+ G H++
Sbjct: 155 LACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSL 214
Query: 424 LLVEETSSQREPSPIP 439
LV+ SQ + P+P
Sbjct: 215 ALVQCLPSQ-DLKPVP 229
Score = 34.3 bits (75), Expect = 1.0
Identities = 35/148 (23%), Positives = 58/148 (39%), Gaps = 17/148 (11%)
Query: 76 GDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTP--KQXXXXXXXXX 133
G ++ G H + L G++++FG R+ E +P +
Sbjct: 40 GKTVLQAALGVKHGVLLTEDGEVYSFGTLP----WRSGPVEICPSSPILENALVGQYVIT 95
Query: 134 XXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPA------ 187
G HS A+ NG Y WG +S G V ++ P PV I E +
Sbjct: 96 VATGSFHSGAVTDNGVAYMWG--ENSAGQ--CAVANQQYVPEPNPVSIADSEASPLLAVR 151
Query: 188 -VEIASGGDHLVVLTTSGGVFTLGCGEQ 214
+++A G +H + L+ S ++ G G Q
Sbjct: 152 ILQLACGEEHTLALSISREIWAWGTGCQ 179
>AB053305-1|BAB69014.1| 1657|Homo sapiens ALS2 protein.
Length = 1657
Score = 52.8 bits (121), Expect = 3e-06
Identities = 38/126 (30%), Positives = 62/126 (49%), Gaps = 19/126 (15%)
Query: 312 ALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQN----KKCISIAAG 367
ALG H + L +G++Y+ G + +SG E P L+N + I++A G
Sbjct: 47 ALGVKHGVLLTEDGEVYSFGTLPW-------RSGPVEICPSSPILENALVGQYVITVATG 99
Query: 368 TSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT-LAAVDSRAP-------LRVSAGG 419
+ +S AVTD+G Y WG S G+ + + EP ++ DS A L+++ G
Sbjct: 100 SFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGE 159
Query: 420 QHTVLL 425
+HT+ L
Sbjct: 160 EHTLAL 165
Score = 50.8 bits (116), Expect = 1e-05
Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFA 373
G+ L + +++ G+ + G+LG GD + L + L K+ I + AG +S A
Sbjct: 515 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPL-CVKCLDGKEVIHLEAGGYHSLA 573
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL-RVSAGGQHTVLLVEETSSQ 432
+T +VYSWG + G+LG + P LA + S + ++AG +++ LV+ Q
Sbjct: 574 LTAKSQVYSWGSNTFGQLGHSDF-PTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQ 632
Score = 49.2 bits (112), Expect = 3e-05
Identities = 27/74 (36%), Positives = 44/74 (59%), Gaps = 2/74 (2%)
Query: 40 PKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKI 98
P R V T G+G GQLG G DV+ + V L G +++ ++AGG H++AL + ++
Sbjct: 522 PSLRTEVWTWGKGKEGQLGHG-DVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQV 580
Query: 99 WTFGCNDEGALGRA 112
+++G N G LG +
Sbjct: 581 YSWGSNTFGQLGHS 594
Score = 39.9 bits (89), Expect = 0.021
Identities = 34/136 (25%), Positives = 60/136 (44%), Gaps = 9/136 (6%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET-------LELIPKLQNKKCIS 363
VA G H+ + NG Y G G+ + ++ E E P L + +
Sbjct: 96 VATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLA-VRILQ 154
Query: 364 IAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTV 423
+A G ++ A++ S E+++WG G + L T + + R L+V+ G H++
Sbjct: 155 LACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSL 214
Query: 424 LLVEETSSQREPSPIP 439
LV+ SQ + P+P
Sbjct: 215 ALVQCLPSQ-DLKPVP 229
Score = 34.3 bits (75), Expect = 1.0
Identities = 35/148 (23%), Positives = 58/148 (39%), Gaps = 17/148 (11%)
Query: 76 GDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTP--KQXXXXXXXXX 133
G ++ G H + L G++++FG R+ E +P +
Sbjct: 40 GKTVLQAALGVKHGVLLTEDGEVYSFGTLP----WRSGPVEICPSSPILENALVGQYVIT 95
Query: 134 XXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPA------ 187
G HS A+ NG Y WG +S G V ++ P PV I E +
Sbjct: 96 VATGSFHSGAVTDNGVAYMWG--ENSAGQ--CAVANQQYVPEPNPVSIADSEASPLLAVR 151
Query: 188 -VEIASGGDHLVVLTTSGGVFTLGCGEQ 214
+++A G +H + L+ S ++ G G Q
Sbjct: 152 ILQLACGEEHTLALSISREIWAWGTGCQ 179
Score = 33.1 bits (72), Expect = 2.4
Identities = 19/68 (27%), Positives = 29/68 (42%), Gaps = 2/68 (2%)
Query: 97 KIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSF 156
++WT+G EG LG + + + G HS AL VY+WGS
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGS- 585
Query: 157 RDSHGSMG 164
++ G +G
Sbjct: 586 -NTFGQLG 592
Score = 31.1 bits (67), Expect = 9.5
Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 4/70 (5%)
Query: 149 DVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFT 208
+V+ WG ++ G V+ R C VK G+ + + +GG H + LT V++
Sbjct: 527 EVWTWGKGKEGQLGHGDVLP-RLQPLC---VKCLDGKEVIHLEAGGYHSLALTAKSQVYS 582
Query: 209 LGCGEQGQLG 218
G GQLG
Sbjct: 583 WGSNTFGQLG 592
>AB046783-1|BAB13389.2| 1658|Homo sapiens KIAA1563 protein protein.
Length = 1658
Score = 52.8 bits (121), Expect = 3e-06
Identities = 38/126 (30%), Positives = 62/126 (49%), Gaps = 19/126 (15%)
Query: 312 ALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQN----KKCISIAAG 367
ALG H + L +G++Y+ G + +SG E P L+N + I++A G
Sbjct: 48 ALGVKHGVLLTEDGEVYSFGTLPW-------RSGPVEICPSSPILENALVGQYVITVATG 100
Query: 368 TSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT-LAAVDSRAP-------LRVSAGG 419
+ +S AVTD+G Y WG S G+ + + EP ++ DS A L+++ G
Sbjct: 101 SFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGE 160
Query: 420 QHTVLL 425
+HT+ L
Sbjct: 161 EHTLAL 166
Score = 50.8 bits (116), Expect = 1e-05
Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFA 373
G+ L + +++ G+ + G+LG GD + L + L K+ I + AG +S A
Sbjct: 516 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPL-CVKCLDGKEVIHLEAGGYHSLA 574
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL-RVSAGGQHTVLLVEETSSQ 432
+T +VYSWG + G+LG + P LA + S + ++AG +++ LV+ Q
Sbjct: 575 LTAKSQVYSWGSNTFGQLGHSDF-PTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQ 633
Score = 49.2 bits (112), Expect = 3e-05
Identities = 27/74 (36%), Positives = 44/74 (59%), Gaps = 2/74 (2%)
Query: 40 PKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKI 98
P R V T G+G GQLG G DV+ + V L G +++ ++AGG H++AL + ++
Sbjct: 523 PSLRTEVWTWGKGKEGQLGHG-DVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQV 581
Query: 99 WTFGCNDEGALGRA 112
+++G N G LG +
Sbjct: 582 YSWGSNTFGQLGHS 595
Score = 39.9 bits (89), Expect = 0.021
Identities = 34/136 (25%), Positives = 60/136 (44%), Gaps = 9/136 (6%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET-------LELIPKLQNKKCIS 363
VA G H+ + NG Y G G+ + ++ E E P L + +
Sbjct: 97 VATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLA-VRILQ 155
Query: 364 IAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTV 423
+A G ++ A++ S E+++WG G + L T + + R L+V+ G H++
Sbjct: 156 LACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSL 215
Query: 424 LLVEETSSQREPSPIP 439
LV+ SQ + P+P
Sbjct: 216 ALVQCLPSQ-DLKPVP 230
Score = 34.3 bits (75), Expect = 1.0
Identities = 35/148 (23%), Positives = 58/148 (39%), Gaps = 17/148 (11%)
Query: 76 GDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTP--KQXXXXXXXXX 133
G ++ G H + L G++++FG R+ E +P +
Sbjct: 41 GKTVLQAALGVKHGVLLTEDGEVYSFGTLP----WRSGPVEICPSSPILENALVGQYVIT 96
Query: 134 XXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPA------ 187
G HS A+ NG Y WG +S G V ++ P PV I E +
Sbjct: 97 VATGSFHSGAVTDNGVAYMWG--ENSAGQ--CAVANQQYVPEPNPVSIADSEASPLLAVR 152
Query: 188 -VEIASGGDHLVVLTTSGGVFTLGCGEQ 214
+++A G +H + L+ S ++ G G Q
Sbjct: 153 ILQLACGEEHTLALSISREIWAWGTGCQ 180
Score = 33.1 bits (72), Expect = 2.4
Identities = 19/68 (27%), Positives = 29/68 (42%), Gaps = 2/68 (2%)
Query: 97 KIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSF 156
++WT+G EG LG + + + G HS AL VY+WGS
Sbjct: 528 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGS- 586
Query: 157 RDSHGSMG 164
++ G +G
Sbjct: 587 -NTFGQLG 593
Score = 31.1 bits (67), Expect = 9.5
Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 4/70 (5%)
Query: 149 DVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFT 208
+V+ WG ++ G V+ R C VK G+ + + +GG H + LT V++
Sbjct: 528 EVWTWGKGKEGQLGHGDVLP-RLQPLC---VKCLDGKEVIHLEAGGYHSLALTAKSQVYS 583
Query: 209 LGCGEQGQLG 218
G GQLG
Sbjct: 584 WGSNTFGQLG 593
>AK023024-1|BAB14362.1| 396|Homo sapiens protein ( Homo sapiens
cDNA FLJ12962 fis, clone NT2RP2005694, weakly similar to
X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR. ).
Length = 396
Score = 52.0 bits (119), Expect = 5e-06
Identities = 38/126 (30%), Positives = 62/126 (49%), Gaps = 19/126 (15%)
Query: 312 ALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQN----KKCISIAAG 367
ALG H + L +G++Y+ G + +SG E P L+N + I++A G
Sbjct: 47 ALGVKHGVLLTEDGEVYSFGTLLW-------RSGPVEICPSSPILENALVGQYVITVATG 99
Query: 368 TSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT-LAAVDSRAP-------LRVSAGG 419
+ +S AVTD+G Y WG S G+ + + EP ++ DS A L+++ G
Sbjct: 100 SFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGE 159
Query: 420 QHTVLL 425
+HT+ L
Sbjct: 160 EHTLAL 165
Score = 39.9 bits (89), Expect = 0.021
Identities = 34/136 (25%), Positives = 60/136 (44%), Gaps = 9/136 (6%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET-------LELIPKLQNKKCIS 363
VA G H+ + NG Y G G+ + ++ E E P L + +
Sbjct: 96 VATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLA-VRILQ 154
Query: 364 IAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTV 423
+A G ++ A++ S E+++WG G + L T + + R L+V+ G H++
Sbjct: 155 LACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSL 214
Query: 424 LLVEETSSQREPSPIP 439
LV+ SQ + P+P
Sbjct: 215 ALVQCLPSQ-DLKPVP 229
Score = 37.1 bits (82), Expect = 0.15
Identities = 36/148 (24%), Positives = 59/148 (39%), Gaps = 17/148 (11%)
Query: 76 GDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTP--KQXXXXXXXXX 133
G ++ G H + L G++++FG L R+ E +P +
Sbjct: 40 GKTVLQAALGVKHGVLLTEDGEVYSFGT----LLWRSGPVEICPSSPILENALVGQYVIT 95
Query: 134 XXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPA------ 187
G HS A+ NG Y WG +S G V ++ P PV I E +
Sbjct: 96 VATGSFHSGAVTDNGVAYMWG--ENSAGQ--CAVANQQYVPEPNPVSIADSEASPLLAVR 151
Query: 188 -VEIASGGDHLVVLTTSGGVFTLGCGEQ 214
+++A G +H + L+ S ++ G G Q
Sbjct: 152 ILQLACGEEHTLALSISREIWAWGTGCQ 179
>AF391100-1|AAL14103.1| 1657|Homo sapiens alsin protein.
Length = 1657
Score = 52.0 bits (119), Expect = 5e-06
Identities = 38/126 (30%), Positives = 62/126 (49%), Gaps = 19/126 (15%)
Query: 312 ALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQN----KKCISIAAG 367
ALG H + L +G++Y+ G + +SG E P L+N + I++A G
Sbjct: 47 ALGVKHGVLLTEDGEVYSFGTLLW-------RSGPVEICPSSPILENALVGQYVITVATG 99
Query: 368 TSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT-LAAVDSRAP-------LRVSAGG 419
+ +S AVTD+G Y WG S G+ + + EP ++ DS A L+++ G
Sbjct: 100 SFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGE 159
Query: 420 QHTVLL 425
+HT+ L
Sbjct: 160 EHTLAL 165
Score = 50.8 bits (116), Expect = 1e-05
Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFA 373
G+ L + +++ G+ + G+LG GD + L + L K+ I + AG +S A
Sbjct: 515 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPL-CVKCLDGKEVIHLEAGGYHSLA 573
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL-RVSAGGQHTVLLVEETSSQ 432
+T +VYSWG + G+LG + P LA + S + ++AG +++ LV+ Q
Sbjct: 574 LTAKSQVYSWGSNTFGQLGHSDF-PTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQ 632
Score = 49.2 bits (112), Expect = 3e-05
Identities = 27/74 (36%), Positives = 44/74 (59%), Gaps = 2/74 (2%)
Query: 40 PKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKI 98
P R V T G+G GQLG G DV+ + V L G +++ ++AGG H++AL + ++
Sbjct: 522 PSLRTEVWTWGKGKEGQLGHG-DVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQV 580
Query: 99 WTFGCNDEGALGRA 112
+++G N G LG +
Sbjct: 581 YSWGSNTFGQLGHS 594
Score = 39.9 bits (89), Expect = 0.021
Identities = 34/136 (25%), Positives = 60/136 (44%), Gaps = 9/136 (6%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET-------LELIPKLQNKKCIS 363
VA G H+ + NG Y G G+ + ++ E E P L + +
Sbjct: 96 VATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLA-VRILQ 154
Query: 364 IAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTV 423
+A G ++ A++ S E+++WG G + L T + + R L+V+ G H++
Sbjct: 155 LACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSL 214
Query: 424 LLVEETSSQREPSPIP 439
LV+ SQ + P+P
Sbjct: 215 ALVQCLPSQ-DLKPVP 229
Score = 37.1 bits (82), Expect = 0.15
Identities = 36/148 (24%), Positives = 59/148 (39%), Gaps = 17/148 (11%)
Query: 76 GDKIVDVQAGGMHTIALDSSGKIWTFGCNDEGALGRATSNEKDEGTP--KQXXXXXXXXX 133
G ++ G H + L G++++FG L R+ E +P +
Sbjct: 40 GKTVLQAALGVKHGVLLTEDGEVYSFGT----LLWRSGPVEICPSSPILENALVGQYVIT 95
Query: 134 XXXGDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPA------ 187
G HS A+ NG Y WG +S G V ++ P PV I E +
Sbjct: 96 VATGSFHSGAVTDNGVAYMWG--ENSAGQ--CAVANQQYVPEPNPVSIADSEASPLLAVR 151
Query: 188 -VEIASGGDHLVVLTTSGGVFTLGCGEQ 214
+++A G +H + L+ S ++ G G Q
Sbjct: 152 ILQLACGEEHTLALSISREIWAWGTGCQ 179
Score = 33.1 bits (72), Expect = 2.4
Identities = 19/68 (27%), Positives = 29/68 (42%), Gaps = 2/68 (2%)
Query: 97 KIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSF 156
++WT+G EG LG + + + G HS AL VY+WGS
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGS- 585
Query: 157 RDSHGSMG 164
++ G +G
Sbjct: 586 -NTFGQLG 592
Score = 31.1 bits (67), Expect = 9.5
Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 4/70 (5%)
Query: 149 DVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFT 208
+V+ WG ++ G V+ R C VK G+ + + +GG H + LT V++
Sbjct: 527 EVWTWGKGKEGQLGHGDVLP-RLQPLC---VKCLDGKEVIHLEAGGYHSLALTAKSQVYS 582
Query: 209 LGCGEQGQLG 218
G GQLG
Sbjct: 583 WGSNTFGQLG 592
>BC113826-1|AAI13827.1| 244|Homo sapiens RCCD1 protein protein.
Length = 244
Score = 50.8 bits (116), Expect = 1e-05
Identities = 48/191 (25%), Positives = 76/191 (39%), Gaps = 18/191 (9%)
Query: 40 PKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIW 99
P++R L + GQLG G E G + +V AGG H++ + +G I+
Sbjct: 41 PRERELELHRFRDPHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIY 100
Query: 100 TFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSFRDS 159
+G N+ G L T N ++G + G V G D
Sbjct: 101 IWGWNESGQLALPTRNLAEDG---ETVAREATELNEDG----------SQVKRTGGAEDG 147
Query: 160 HGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFTLGCGEQGQLGR 219
+ + V +P + + +G AV+ + G H V+T +G ++T G G+ GQLG
Sbjct: 148 APAPFIAV-----QPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGH 202
Query: 220 LAQRSASRDAR 230
S R R
Sbjct: 203 EDTTSLDRPRR 213
Score = 39.5 bits (88), Expect = 0.027
Identities = 20/60 (33%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
Query: 332 RCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFAVTDSGEVYSWGMGSEGKL 391
R +G+LG G + E L+ LQ +AAG +S V+++G++Y WG G+L
Sbjct: 52 RDPHGQLGHGTLEAELEP-RLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQL 110
Score = 37.9 bits (84), Expect = 0.083
Identities = 14/41 (34%), Positives = 26/41 (63%)
Query: 362 ISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEP 402
+ + G+ ++ VT +GE+Y+WG G G+LG ++ L+ P
Sbjct: 171 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRP 211
>BC029174-1|AAH29174.1| 812|Homo sapiens ALS2 protein protein.
Length = 812
Score = 50.8 bits (116), Expect = 1e-05
Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFA 373
G+ L + +++ G+ + G+LG GD + L + L K+ I + AG +S A
Sbjct: 515 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPL-CVKCLDGKEVIHLEAGGYHSLA 573
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL-RVSAGGQHTVLLVEETSSQ 432
+T +VYSWG + G+LG + P LA + S + ++AG +++ LV+ Q
Sbjct: 574 LTAKSQVYSWGSNTFGQLGHSDF-PTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQ 632
Score = 49.2 bits (112), Expect = 3e-05
Identities = 27/74 (36%), Positives = 44/74 (59%), Gaps = 2/74 (2%)
Query: 40 PKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKI 98
P R V T G+G GQLG G DV+ + V L G +++ ++AGG H++AL + ++
Sbjct: 522 PSLRTEVWTWGKGKEGQLGHG-DVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQV 580
Query: 99 WTFGCNDEGALGRA 112
+++G N G LG +
Sbjct: 581 YSWGSNTFGQLGHS 594
Score = 47.6 bits (108), Expect = 1e-04
Identities = 37/126 (29%), Positives = 61/126 (48%), Gaps = 19/126 (15%)
Query: 312 ALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQN----KKCISIAAG 367
ALG H + L +G++Y+ G + +SG E P L+N + I++A G
Sbjct: 47 ALGVKHGVLLTEDGEVYSFGTLPW-------RSGPVEICPSSPILENALVGQYVITVATG 99
Query: 368 TSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPT-LAAVDSRAP-------LRVSAGG 419
+ +S AVTD+G Y G S G+ + + EP ++ DS A L+++ G
Sbjct: 100 SFHSGAVTDNGVAYMCGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGE 159
Query: 420 QHTVLL 425
+HT+ L
Sbjct: 160 EHTLAL 165
Score = 40.3 bits (90), Expect = 0.016
Identities = 34/136 (25%), Positives = 60/136 (44%), Gaps = 9/136 (6%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET-------LELIPKLQNKKCIS 363
VA G H+ + NG Y G G+ + ++ E E P L + +
Sbjct: 96 VATGSFHSGAVTDNGVAYMCGENSAGQCAVANQQYVPEPNPVSIADSEASPLLA-VRILQ 154
Query: 364 IAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTV 423
+A G ++ A++ S E+++WG G + L T + + R L+V+ G H++
Sbjct: 155 LACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSL 214
Query: 424 LLVEETSSQREPSPIP 439
LV+ SQ + P+P
Sbjct: 215 ALVQCLPSQ-DLKPVP 229
Score = 33.1 bits (72), Expect = 2.4
Identities = 19/68 (27%), Positives = 29/68 (42%), Gaps = 2/68 (2%)
Query: 97 KIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSF 156
++WT+G EG LG + + + G HS AL VY+WGS
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGS- 585
Query: 157 RDSHGSMG 164
++ G +G
Sbjct: 586 -NTFGQLG 592
Score = 31.1 bits (67), Expect = 9.5
Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 4/70 (5%)
Query: 149 DVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFT 208
+V+ WG ++ G V+ R C VK G+ + + +GG H + LT V++
Sbjct: 527 EVWTWGKGKEGQLGHGDVLP-RLQPLC---VKCLDGKEVIHLEAGGYHSLALTAKSQVYS 582
Query: 209 LGCGEQGQLG 218
G GQLG
Sbjct: 583 WGSNTFGQLG 592
>AC007279-1|AAY15058.1| 1598|Homo sapiens unknown protein.
Length = 1598
Score = 50.8 bits (116), Expect = 1e-05
Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 314 GQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNSFA 373
G+ L + +++ G+ + G+LG GD + L + L K+ I + AG +S A
Sbjct: 456 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPL-CVKCLDGKEVIHLEAGGYHSLA 514
Query: 374 VTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL-RVSAGGQHTVLLVEETSSQ 432
+T +VYSWG + G+LG + P LA + S + ++AG +++ LV+ Q
Sbjct: 515 LTAKSQVYSWGSNTFGQLGHSDF-PTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQ 573
Score = 49.2 bits (112), Expect = 3e-05
Identities = 27/74 (36%), Positives = 44/74 (59%), Gaps = 2/74 (2%)
Query: 40 PKKRGRVLTCGQGDVGQLGLGEDVVETTKFKYVTAL-GDKIVDVQAGGMHTIALDSSGKI 98
P R V T G+G GQLG G DV+ + V L G +++ ++AGG H++AL + ++
Sbjct: 463 PSLRTEVWTWGKGKEGQLGHG-DVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQV 521
Query: 99 WTFGCNDEGALGRA 112
+++G N G LG +
Sbjct: 522 YSWGSNTFGQLGHS 535
Score = 44.4 bits (100), Expect = 0.001
Identities = 33/113 (29%), Positives = 55/113 (48%), Gaps = 19/113 (16%)
Query: 325 GQIYALGRCEYGRLGLGDKSGDAETLELIPKLQN----KKCISIAAGTSNSFAVTDSGEV 380
G++Y+ G + +SG E P L+N + I++A G+ +S AVTD+G
Sbjct: 1 GEVYSFGTLPW-------RSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVA 53
Query: 381 YSWGMGSEGKLGTGESEDLNEPT-LAAVDSRAP-------LRVSAGGQHTVLL 425
Y WG S G+ + + EP ++ DS A L+++ G +HT+ L
Sbjct: 54 YMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLAL 106
Score = 39.9 bits (89), Expect = 0.021
Identities = 34/136 (25%), Positives = 60/136 (44%), Gaps = 9/136 (6%)
Query: 311 VALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAET-------LELIPKLQNKKCIS 363
VA G H+ + NG Y G G+ + ++ E E P L + +
Sbjct: 37 VATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLA-VRILQ 95
Query: 364 IAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGGQHTV 423
+A G ++ A++ S E+++WG G + L T + + R L+V+ G H++
Sbjct: 96 LACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSL 155
Query: 424 LLVEETSSQREPSPIP 439
LV+ SQ + P+P
Sbjct: 156 ALVQCLPSQ-DLKPVP 170
Score = 33.1 bits (72), Expect = 2.4
Identities = 19/68 (27%), Positives = 29/68 (42%), Gaps = 2/68 (2%)
Query: 97 KIWTFGCNDEGALGRATSNEKDEGTPKQXXXXXXXXXXXXGDSHSAALLQNGDVYAWGSF 156
++WT+G EG LG + + + G HS AL VY+WGS
Sbjct: 468 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGS- 526
Query: 157 RDSHGSMG 164
++ G +G
Sbjct: 527 -NTFGQLG 533
Score = 31.9 bits (69), Expect = 5.5
Identities = 25/85 (29%), Positives = 38/85 (44%), Gaps = 11/85 (12%)
Query: 137 GDSHSAALLQNGDVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPA-------VE 189
G HS A+ NG Y WG +S G V ++ P PV I E + ++
Sbjct: 40 GSFHSGAVTDNGVAYMWG--ENSAGQ--CAVANQQYVPEPNPVSIADSEASPLLAVRILQ 95
Query: 190 IASGGDHLVVLTTSGGVFTLGCGEQ 214
+A G +H + L+ S ++ G G Q
Sbjct: 96 LACGEEHTLALSISREIWAWGTGCQ 120
Score = 31.1 bits (67), Expect = 9.5
Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 4/70 (5%)
Query: 149 DVYAWGSFRDSHGSMGLVVRGREGKPCKEPVKIDIGEPAVEIASGGDHLVVLTTSGGVFT 208
+V+ WG ++ G V+ R C VK G+ + + +GG H + LT V++
Sbjct: 468 EVWTWGKGKEGQLGHGDVLP-RLQPLC---VKCLDGKEVIHLEAGGYHSLALTAKSQVYS 523
Query: 209 LGCGEQGQLG 218
G GQLG
Sbjct: 524 WGSNTFGQLG 533
>AY650034-1|AAV66580.1| 110|Homo sapiens HECT and RCC1 containing
protein 4 isoform 4 protein.
Length = 110
Score = 48.0 bits (109), Expect = 8e-05
Identities = 29/78 (37%), Positives = 40/78 (51%), Gaps = 6/78 (7%)
Query: 46 VLTCGQGDVGQLGLG----EDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+L G GQLGLG E V+E K + + ++ DV G HT+ + G ++T
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF--INKRVRDVGCGLRHTVFVLDDGTVYTC 58
Query: 102 GCNDEGALGRATSNEKDE 119
GCND G LG S +K E
Sbjct: 59 GCNDLGQLGHEKSRKKPE 76
Score = 39.1 bits (87), Expect = 0.036
Identities = 33/100 (33%), Positives = 47/100 (47%), Gaps = 9/100 (9%)
Query: 153 WGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLG 210
WG+ S G +GL G + + EP K D I + ++ G H V + G V+T G
Sbjct: 4 WGNA--SFGQLGL--GGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCG 59
Query: 211 CGEQGQLGRLAQRSAS--RDARQGFSALLVPARVTLRQAA 248
C + GQLG R R G SA + P+R+T A+
Sbjct: 60 CNDLGQLGHEKSRKKPEFRSCFPGRSA-MAPSRLTATSAS 98
Score = 35.1 bits (77), Expect = 0.59
Identities = 28/93 (30%), Positives = 42/93 (45%), Gaps = 9/93 (9%)
Query: 331 GRCEYGRLGLGDKSGDAETLELIPKLQ----NKKCISIAAGTSNSFAVTDSGEVYSWGMG 386
G +G+LGLG G E + L P+ NK+ + G ++ V D G VY+ G
Sbjct: 5 GNASFGQLGLG---GIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCN 61
Query: 387 SEGKLGTGESEDLNE--PTLAAVDSRAPLRVSA 417
G+LG +S E + AP R++A
Sbjct: 62 DLGQLGHEKSRKKPEFRSCFPGRSAMAPSRLTA 94
>AY650032-1|AAV66578.1| 117|Homo sapiens HECT and RCC1 containing
protein 4 isoform 2 protein.
Length = 117
Score = 48.0 bits (109), Expect = 8e-05
Identities = 29/78 (37%), Positives = 40/78 (51%), Gaps = 6/78 (7%)
Query: 46 VLTCGQGDVGQLGLG----EDVVETTKFKYVTALGDKIVDVQAGGMHTIALDSSGKIWTF 101
+L G GQLGLG E V+E K + + ++ DV G HT+ + G ++T
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFF--INKRVRDVGCGLRHTVFVLDDGTVYTC 58
Query: 102 GCNDEGALGRATSNEKDE 119
GCND G LG S +K E
Sbjct: 59 GCNDLGQLGHEKSRKKPE 76
Score = 35.1 bits (77), Expect = 0.59
Identities = 25/73 (34%), Positives = 35/73 (47%), Gaps = 6/73 (8%)
Query: 153 WGSFRDSHGSMGLVVRGREGKPCKEPVKID--IGEPAVEIASGGDHLVVLTTSGGVFTLG 210
WG+ S G +GL G + + EP K D I + ++ G H V + G V+T G
Sbjct: 4 WGNA--SFGQLGL--GGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCG 59
Query: 211 CGEQGQLGRLAQR 223
C + GQLG R
Sbjct: 60 CNDLGQLGHEKSR 72
Score = 34.7 bits (76), Expect = 0.78
Identities = 23/70 (32%), Positives = 34/70 (48%), Gaps = 7/70 (10%)
Query: 331 GRCEYGRLGLGDKSGDAETLELIPKLQ----NKKCISIAAGTSNSFAVTDSGEVYSWGMG 386
G +G+LGLG G E + L P+ NK+ + G ++ V D G VY+ G
Sbjct: 5 GNASFGQLGLG---GIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCN 61
Query: 387 SEGKLGTGES 396
G+LG +S
Sbjct: 62 DLGQLGHEKS 71
>BC067293-1|AAH67293.1| 580|Homo sapiens F-box protein 24 protein.
Length = 580
Score = 37.9 bits (84), Expect = 0.083
Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 1/75 (1%)
Query: 360 KCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGG 419
K + A G ++ V + G ++ G G+LGTG+ D EPT R P+ + G
Sbjct: 358 KILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCYLQR-PITLWCGL 416
Query: 420 QHTVLLVEETSSQRE 434
H+++L + + +E
Sbjct: 417 NHSLVLSQSSEFSKE 431
Score = 35.1 bits (77), Expect = 0.59
Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 7/84 (8%)
Query: 312 ALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNS 371
ALG +H + G+I+ G YG+LG GDK E + + LQ + I++ G ++S
Sbjct: 363 ALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQ-VCYLQ--RPITLWCGLNHS 419
Query: 372 FAVTDSG----EVYSWGMGSEGKL 391
++ S E+ G G+ G+L
Sbjct: 420 LVLSQSSEFSKELLGCGCGAGGRL 443
>AC069281-1|AAP21863.1| 580|Homo sapiens unknown protein.
Length = 580
Score = 37.9 bits (84), Expect = 0.083
Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 1/75 (1%)
Query: 360 KCISIAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPLRVSAGG 419
K + A G ++ V + G ++ G G+LGTG+ D EPT R P+ + G
Sbjct: 358 KILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVCYLQR-PITLWCGL 416
Query: 420 QHTVLLVEETSSQRE 434
H+++L + + +E
Sbjct: 417 NHSLVLSQSSEFSKE 431
Score = 35.1 bits (77), Expect = 0.59
Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 7/84 (8%)
Query: 312 ALGQHHTLTLAANGQIYALGRCEYGRLGLGDKSGDAETLELIPKLQNKKCISIAAGTSNS 371
ALG +H + G+I+ G YG+LG GDK E + + LQ + I++ G ++S
Sbjct: 363 ALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQ-VCYLQ--RPITLWCGLNHS 419
Query: 372 FAVTDSG----EVYSWGMGSEGKL 391
++ S E+ G G+ G+L
Sbjct: 420 LVLSQSSEFSKELLGCGCGAGGRL 443
>BC113035-1|AAI13036.1| 140|Homo sapiens FSD1L protein protein.
Length = 140
Score = 34.3 bits (75), Expect = 1.0
Identities = 21/48 (43%), Positives = 27/48 (56%), Gaps = 3/48 (6%)
Query: 384 GMGSEGKLGT-GESEDLN--EPTLAAVDSRAPLRVSAGGQHTVLLVEE 428
G SEGKL T G+S + E L A SRAP+ + GG++T EE
Sbjct: 2 GSSSEGKLATKGDSSERERREQNLPARPSRAPVSICGGGENTSKSAEE 49
>BC105053-1|AAI05054.1| 643|Homo sapiens praja 1 protein.
Length = 643
Score = 32.3 bits (70), Expect = 4.1
Identities = 20/45 (44%), Positives = 26/45 (57%), Gaps = 3/45 (6%)
Query: 387 SEGKLGT-GESEDLN--EPTLAAVDSRAPLRVSAGGQHTVLLVEE 428
SEGKL T G+S + E L A SRAP+ + GG++T EE
Sbjct: 209 SEGKLATKGDSSERERREQNLPARPSRAPVSICGGGENTSKSAEE 253
>BC105051-1|AAI05052.1| 643|Homo sapiens praja 1 protein.
Length = 643
Score = 32.3 bits (70), Expect = 4.1
Identities = 20/45 (44%), Positives = 26/45 (57%), Gaps = 3/45 (6%)
Query: 387 SEGKLGT-GESEDLN--EPTLAAVDSRAPLRVSAGGQHTVLLVEE 428
SEGKL T G+S + E L A SRAP+ + GG++T EE
Sbjct: 209 SEGKLATKGDSSERERREQNLPARPSRAPVSICGGGENTSKSAEE 253
>BC075803-1|AAH75803.1| 643|Homo sapiens praja 1 protein.
Length = 643
Score = 32.3 bits (70), Expect = 4.1
Identities = 20/45 (44%), Positives = 26/45 (57%), Gaps = 3/45 (6%)
Query: 387 SEGKLGT-GESEDLN--EPTLAAVDSRAPLRVSAGGQHTVLLVEE 428
SEGKL T G+S + E L A SRAP+ + GG++T EE
Sbjct: 209 SEGKLATKGDSSERERREQNLPARPSRAPVSICGGGENTSKSAEE 253
>AL157699-2|CAI41604.1| 643|Homo sapiens praja 1 protein.
Length = 643
Score = 32.3 bits (70), Expect = 4.1
Identities = 20/45 (44%), Positives = 26/45 (57%), Gaps = 3/45 (6%)
Query: 387 SEGKLGT-GESEDLN--EPTLAAVDSRAPLRVSAGGQHTVLLVEE 428
SEGKL T G+S + E L A SRAP+ + GG++T EE
Sbjct: 209 SEGKLATKGDSSERERREQNLPARPSRAPVSICGGGENTSKSAEE 253
>AL157699-1|CAM24741.1| 588|Homo sapiens praja 1 protein.
Length = 588
Score = 32.3 bits (70), Expect = 4.1
Identities = 20/45 (44%), Positives = 26/45 (57%), Gaps = 3/45 (6%)
Query: 387 SEGKLGT-GESEDLN--EPTLAAVDSRAPLRVSAGGQHTVLLVEE 428
SEGKL T G+S + E L A SRAP+ + GG++T EE
Sbjct: 154 SEGKLATKGDSSERERREQNLPARPSRAPVSICGGGENTSKSAEE 198
>AF262024-1|AAM53039.1| 643|Homo sapiens PJA1 protein.
Length = 643
Score = 32.3 bits (70), Expect = 4.1
Identities = 20/45 (44%), Positives = 26/45 (57%), Gaps = 3/45 (6%)
Query: 387 SEGKLGT-GESEDLN--EPTLAAVDSRAPLRVSAGGQHTVLLVEE 428
SEGKL T G+S + E L A SRAP+ + GG++T EE
Sbjct: 209 SEGKLATKGDSSERERREQNLPARPSRAPVSICGGGENTSKSAEE 253
>AF026547-1|AAC80576.1| 1321|Homo sapiens neurocan protein.
Length = 1321
Score = 31.5 bits (68), Expect = 7.2
Identities = 23/69 (33%), Positives = 37/69 (53%), Gaps = 8/69 (11%)
Query: 378 GEVYSWGMGSEGKLGTGESEDLNE--PTL-----AAVDSRAPLRVSAGGQHTVLLVEETS 430
G++ + G EG++ + E + E PTL D + PL VS+G + T++L E+
Sbjct: 366 GDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPDFQEPL-VSSGEEETLILEEKQE 424
Query: 431 SQREPSPIP 439
SQ+ SP P
Sbjct: 425 SQQTLSPTP 433
>AC003110-2|AAB86655.1| 990|Homo sapiens PGCN_HUMAN protein.
Length = 990
Score = 31.5 bits (68), Expect = 7.2
Identities = 23/69 (33%), Positives = 37/69 (53%), Gaps = 8/69 (11%)
Query: 378 GEVYSWGMGSEGKLGTGESEDLNE--PTL-----AAVDSRAPLRVSAGGQHTVLLVEETS 430
G++ + G EG++ + E + E PTL D + PL VS+G + T++L E+
Sbjct: 366 GDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPDFQEPL-VSSGEEETLILEEKQE 424
Query: 431 SQREPSPIP 439
SQ+ SP P
Sbjct: 425 SQQTLSPTP 433
>AB210004-1|BAE06086.1| 1335|Homo sapiens CSPG3 variant protein
protein.
Length = 1335
Score = 31.5 bits (68), Expect = 7.2
Identities = 23/69 (33%), Positives = 37/69 (53%), Gaps = 8/69 (11%)
Query: 378 GEVYSWGMGSEGKLGTGESEDLNE--PTL-----AAVDSRAPLRVSAGGQHTVLLVEETS 430
G++ + G EG++ + E + E PTL D + PL VS+G + T++L E+
Sbjct: 380 GDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPDFQEPL-VSSGEEETLILEEKQE 438
Query: 431 SQREPSPIP 439
SQ+ SP P
Sbjct: 439 SQQTLSPTP 447
>BC009336-1|AAH09336.2| 326|Homo sapiens NEK9 protein protein.
Length = 326
Score = 31.1 bits (67), Expect = 9.5
Identities = 19/78 (24%), Positives = 36/78 (46%), Gaps = 9/78 (11%)
Query: 364 IAAGTSNSFAVTDSGEVYSWGMGSEGKLGTGESEDLNEPTLAAVDSRAPL--------RV 415
++ G + A TD +++WG G G+L +E + + R P+ +
Sbjct: 2 VSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPR-PIFGSLHHVPDL 60
Query: 416 SAGGQHTVLLVEETSSQR 433
S G HT+L+VE+ + +
Sbjct: 61 SCRGWHTILIVEKVLNSK 78
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.312 0.132 0.384
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 68,598,721
Number of Sequences: 224733
Number of extensions: 2693009
Number of successful extensions: 6547
Number of sequences better than 10.0: 111
Number of HSP's better than 10.0 without gapping: 100
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 4570
Number of HSP's gapped (non-prelim): 703
length of query: 506
length of database: 73,234,838
effective HSP length: 93
effective length of query: 413
effective length of database: 52,334,669
effective search space: 21614218297
effective search space used: 21614218297
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 42 (21.8 bits)
S2: 67 (31.1 bits)
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