Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000060-TA|BGIBMGA000060-PA|IPR003018|GAF,
IPR002073|3'5'-cyclic nucleotide phosphodiesterase, IPR001998|Xylose
isomerase, IPR003607|Metal-dependent phosphohydrolase, HD region
(852 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
D89094-1|BAA28945.1| 875|Homo sapiens 3',5'-cyclic GMP phosphod... 492 e-138
BC126233-1|AAI26234.1| 875|Homo sapiens phosphodiesterase 5A, c... 492 e-138
AY264918-1|AAP21809.1| 833|Homo sapiens phosphodiesterase 5A pr... 492 e-138
AJ004865-1|CAA06170.1| 875|Homo sapiens cGMP-binding, cGMP-spec... 492 e-138
AF043731-1|AAC63967.1| 875|Homo sapiens cGMP-binding cGMP-speci... 492 e-138
AB001635-1|BAA33372.2| 875|Homo sapiens cGMP-binding cGMP-speci... 492 e-138
AB015656-1|BAA81667.1| 833|Homo sapiens cGMP-binding cGMP speci... 489 e-137
BC114431-1|AAI14432.1| 934|Homo sapiens phosphodiesterase 11A p... 450 e-125
BC112393-1|AAI12394.1| 934|Homo sapiens phosphodiesterase 11A p... 450 e-125
AJ278682-1|CAC15567.1| 684|Homo sapiens cAMP/cGMP cyclic nucleo... 450 e-125
AB048423-2|BAB62712.1| 934|Homo sapiens phosphodiesterase 11A4 ... 450 e-125
AB048423-1|BAB62713.2| 684|Homo sapiens phosphodiesterase 11A3 ... 450 e-125
AB038041-1|BAB16372.1| 684|Homo sapiens phosphodiesterase 11A3 ... 450 e-125
AB036704-1|BAB16371.1| 934|Homo sapiens phosphodiesterase 11A p... 450 e-125
AJ251509-1|CAB82573.1| 490|Homo sapiens cyclic nucleotide phosp... 447 e-125
AF281865-1|AAG32023.1| 576|Homo sapiens cAMP/cGMP phosphodieste... 447 e-125
AB048423-3|BAB62714.1| 490|Homo sapiens phosphodiesterase 11A1 ... 447 e-125
AL356214-7|CAH72330.1| 858|Homo sapiens phosphodiesterase 6C, c... 392 e-108
AL157396-4|CAH73839.1| 858|Homo sapiens phosphodiesterase 6C, c... 392 e-108
X94354-1|CAA64079.1| 858|Homo sapiens cone cGMP phosphodiestera... 392 e-108
U20212-1|AAA92886.1| 858|Homo sapiens cone photoreceptor cGMP-p... 390 e-108
U31973-1|AAA96392.1| 858|Homo sapiens phosphodiesterase A' subu... 390 e-107
BC035909-1|AAH35909.1| 860|Homo sapiens phosphodiesterase 6A, c... 378 e-104
M26061-1|AAB69155.1| 860|Homo sapiens PDEA protein. 378 e-104
AC093752-1|AAY40985.1| 331|Homo sapiens unknown protein. 372 e-102
X66142-1|CAA46932.1| 854|Homo sapiens 3',5'-cyclic-nucleotide ... 368 e-101
S41458-1|AAB22690.1| 854|Homo sapiens rod cGMP phosphodiesteras... 368 e-101
X62692-1|CAA44569.1| 854|Homo sapiens cGMP phosphodiesterase be... 367 e-101
BT009794-1|AAP88796.1| 853|Homo sapiens phosphodiesterase 6B, c... 367 e-101
BC000249-1|AAH00249.1| 853|Homo sapiens phosphodiesterase 6B, c... 367 e-101
X90587-1|CAA62215.1| 617|Homo sapiens Rod cGMP phosphodiesteras... 349 2e-95
BC104860-1|AAI04861.1| 779|Homo sapiens phosphodiesterase 10A p... 317 9e-86
BC104858-1|AAI04859.1| 779|Homo sapiens phosphodiesterase 10A p... 317 9e-86
AL160160-1|CAH72023.1| 779|Homo sapiens phosphodiesterase 10A p... 317 9e-86
AL136130-1|CAI20436.1| 779|Homo sapiens phosphodiesterase 10A p... 317 9e-86
AL117345-1|CAB92797.2| 779|Homo sapiens phosphodiesterase 10A p... 317 9e-86
AF127480-1|AAD32596.1| 807|Homo sapiens 3',5'-cyclic nucleotide... 317 9e-86
AF127479-1|AAD32595.1| 779|Homo sapiens 3',5'-cyclic nucleotide... 317 9e-86
AB041798-3|BAB16383.1| 714|Homo sapiens phosphodiesterase 10A1 ... 317 9e-86
AB026816-1|BAA84467.1| 789|Homo sapiens 3',5'-cyclic nucleotide... 317 9e-86
AB020593-1|BAA78034.1| 779|Homo sapiens 3',5'-Cyclic nucleotide... 317 9e-86
CR536567-1|CAG38804.1| 779|Homo sapiens PDE10A protein. 315 5e-85
AC012499-1|AAY14803.1| 325|Homo sapiens unknown protein. 310 1e-83
U67733-1|AAC51320.1| 941|Homo sapiens PDE2A3 protein. 305 5e-82
AK131525-1|BAD18664.1| 685|Homo sapiens protein ( Homo sapiens ... 305 5e-82
AY495087-1|AAS75513.1| 932|Homo sapiens cGMP-stimulated phospho... 303 2e-81
BC040974-1|AAH40974.1| 941|Homo sapiens phosphodiesterase 2A, c... 302 4e-81
BT007016-1|AAP35662.1| 533|Homo sapiens phosphodiesterase 9A pr... 157 1e-37
BC009047-1|AAH09047.1| 533|Homo sapiens phosphodiesterase 9A pr... 157 1e-37
AY701187-1|AAV84271.1| 485|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY242121-1|AAO88210.1| 492|Homo sapiens type 9 cGMP-specific ph... 157 1e-37
AY196314-1|AAO34700.1| 386|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196313-1|AAO34699.1| 386|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196312-1|AAO34698.1| 567|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196311-1|AAO34697.1| 552|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196310-1|AAO34696.1| 526|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196309-1|AAO34695.1| 376|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196308-1|AAO34694.1| 386|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196307-1|AAO34693.1| 491|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196306-1|AAO34692.1| 459|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196305-1|AAO34691.1| 376|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196304-1|AAO34690.1| 433|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196303-1|AAO34689.1| 507|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196302-1|AAO34688.1| 386|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196301-1|AAO34687.1| 386|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196300-1|AAO34686.1| 492|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AY196299-1|AAO34685.1| 540|Homo sapiens phosphodiesterase PDE9A... 157 1e-37
AP001747-1|BAA95552.1| 593|Homo sapiens CGMP-specific 3',5'-cyc... 157 1e-37
AF067226-1|AAC26726.1| 465|Homo sapiens cGMP phosphodiesterase ... 157 1e-37
AF067225-1|AAC26725.1| 466|Homo sapiens cGMP phosphodiesterase ... 157 1e-37
AF067224-1|AAC26724.1| 533|Homo sapiens cGMP phosphodiesterase ... 157 1e-37
AF067223-1|AAC26723.1| 593|Homo sapiens cGMP phosphodiesterase ... 157 1e-37
AF048837-1|AAC39778.1| 593|Homo sapiens cGMP-specific phosphodi... 157 1e-37
AB017602-1|BAA88847.1| 593|Homo sapiens cGMP phosphodiesterase ... 157 1e-37
U40370-1|AAC50436.1| 535|Homo sapiens 3',5' cyclic nucleotide p... 139 3e-32
BC022480-1|AAH22480.1| 545|Homo sapiens phosphodiesterase 1A, c... 139 3e-32
AL110263-1|CAB53703.1| 519|Homo sapiens hypothetical protein pr... 139 3e-32
AJ401610-1|CAC82208.1| 519|Homo sapiens 3'5' cyclic nucleotide ... 139 3e-32
AB038224-9|BAB20054.1| 518|Homo sapiens calmodulin-dependent ph... 139 3e-32
AB038224-8|BAB20053.1| 501|Homo sapiens calmodulin-dependent ph... 139 3e-32
AB038224-7|BAB20057.1| 511|Homo sapiens calmodulin-dependent ph... 139 3e-32
AB038224-6|BAB20052.1| 552|Homo sapiens calmodulin-dependent ph... 139 3e-32
AB038224-5|BAB20050.1| 535|Homo sapiens calmodulin-dependent ph... 139 3e-32
AB038224-4|BAB20056.1| 545|Homo sapiens calmodulin-dependent ph... 139 3e-32
AB038224-3|BAB20051.1| 536|Homo sapiens calmodulin-dependent ph... 139 3e-32
AB038224-2|BAB20049.1| 519|Homo sapiens calmodulin-dependent ph... 139 3e-32
AB038224-1|BAB20055.1| 529|Homo sapiens calmodulin-dependent ph... 139 3e-32
U40372-1|AAA96961.1| 564|Homo sapiens PDE1C3 protein. 134 1e-30
U40371-1|AAC50437.1| 634|Homo sapiens 3',5' cyclic nucleotide p... 134 1e-30
BC022525-1|AAH22525.1| 634|Homo sapiens PDE1C protein protein. 134 1e-30
BC022479-1|AAH22479.1| 634|Homo sapiens PDE1C protein protein. 134 1e-30
AK091734-1|BAC03734.1| 769|Homo sapiens (EC 3.1.4.17). protein. 134 1e-30
AC006377-1|AAS07516.1| 591|Homo sapiens unknown protein. 134 1e-30
U97584-1|AAC25679.1| 647|Homo sapiens cyclic AMP-specific phosp... 132 5e-30
U68532-1|AAC63832.1| 647|Homo sapiens cyclic AMP specific phosp... 132 5e-30
U18087-1|AAC50458.1| 686|Homo sapiens 3',5'-cyclic AMP phosphod... 132 5e-30
S75213-1|AAB33798.1| 667|Homo sapiens type-IVA cyclic AMP speci... 132 5e-30
M37744-1|AAA69697.1| 775|Homo sapiens protein ( Human cyclic AM... 132 5e-30
L20965-1|AAA03588.1| 886|Homo sapiens phosphodiesterase protein. 132 5e-30
BC038234-1|AAH38234.1| 647|Homo sapiens phosphodiesterase 4A, c... 132 5e-30
BC019864-1|AAH19864.1| 647|Homo sapiens phosphodiesterase 4A, c... 132 5e-30
AY618547-1|AAU82096.1| 860|Homo sapiens cyclic AMP phosphodiest... 132 5e-30
AY593872-1|AAT00628.1| 864|Homo sapiens cAMP-specific phosphodi... 132 5e-30
AF073745-1|AAD34217.2| 825|Homo sapiens cyclic AMP-specific pho... 132 5e-30
AF069491-3|AAC35013.1| 647|Homo sapiens cAMP specific phosphodi... 132 5e-30
AF069491-2|AAC35015.1| 860|Homo sapiens putative novel cAMP spe... 132 5e-30
AF069491-1|AAC35012.1| 886|Homo sapiens cAMP specific phosphodi... 132 5e-30
U88713-1|AAC51916.1| 700|Homo sapiens phosphodiesterase 4C prot... 128 6e-29
U88712-1|AAC51915.1| 606|Homo sapiens phosphodiesterase 4C prot... 128 6e-29
U66348-1|AAB96877.1| 518|Homo sapiens PDE4C-delta54 protein. 128 6e-29
U66347-1|AAB96876.1| 426|Homo sapiens PDE4C-426 protein. 128 6e-29
U66346-1|AAB96875.1| 791|Homo sapiens PDE4C-791 protein. 128 6e-29
BC109068-1|AAI09069.1| 549|Homo sapiens PDE4C protein protein. 128 6e-29
BC109067-1|AAI09068.1| 481|Homo sapiens PDE4C protein protein. 128 6e-29
AF157816-3|AAD47055.1| 606|Homo sapiens cAMP specific phosphodi... 128 6e-29
AF157816-2|AAD47054.1| 680|Homo sapiens cAMP specific phosphodi... 128 6e-29
AF157816-1|AAD47053.1| 712|Homo sapiens cAMP specific phosphodi... 128 6e-29
AC005759-5|AAC83049.1| 426|Homo sapiens PDE4C-426 protein. 128 6e-29
AC005759-3|AAC83051.1| 518|Homo sapiens PDE4C-delta54 protein. 128 6e-29
AC005759-1|AAC83050.1| 782|Homo sapiens PDE4C-791 protein. 128 6e-29
U86078-1|AAC51872.1| 536|Homo sapiens calmodulin-stimulated pho... 128 1e-28
U56976-1|AAC50769.1| 536|Homo sapiens calmodulin dependent phos... 128 1e-28
BX538092-1|CAD98011.1| 399|Homo sapiens hypothetical protein pr... 128 1e-28
BC032226-1|AAH32226.1| 536|Homo sapiens phosphodiesterase 1B, c... 128 1e-28
AJ401609-1|CAC82207.1| 516|Homo sapiens 3'5' cyclic nucleotide ... 128 1e-28
Z46632-1|CAA86601.1| 712|Homo sapiens 3',5'-cyclic AMP phosphod... 127 1e-28
U02882-1|AAC13745.1| 604|Homo sapiens 3',5'-cyclic AMP phosphod... 127 1e-28
U50159-1|AAA97892.1| 673|Homo sapiens cAMP-specific phoshodiest... 127 2e-28
U50158-1|AAA97891.1| 507|Homo sapiens cAMP-specific phosphodies... 127 2e-28
U50157-1|AAA97890.1| 585|Homo sapiens cAMP-specific phosphodies... 127 2e-28
L20970-1|AAA03592.1| 673|Homo sapiens phosphodiesterase protein. 127 2e-28
L20969-1|AAC00042.1| 809|Homo sapiens cyclic AMP phosphodiester... 127 2e-28
AY388960-1|AAQ90404.1| 679|Homo sapiens cAMP-specific phosphodi... 127 2e-28
AY245867-1|AAP75761.1| 679|Homo sapiens cAMP-specific phosphodi... 127 2e-28
AY245866-1|AAP75760.1| 748|Homo sapiens cAMP-specific phosphodi... 127 2e-28
AF536976-1|AAN10118.1| 748|Homo sapiens cAMP-specific phosphodi... 127 2e-28
AF536975-1|AAN10117.1| 518|Homo sapiens cAMP-specific phosphodi... 127 2e-28
AF012074-1|AAC00070.1| 507|Homo sapiens cAMP-specific phosphodi... 127 2e-28
AF012073-1|AAC00069.1| 745|Homo sapiens cAMP-specific phosphodi... 127 2e-28
AF536977-1|AAN10119.1| 687|Homo sapiens cAMP-specific phosphodi... 126 3e-28
U67932-1|AAB65772.1| 456|Homo sapiens cAMP phosphodiesterase PD... 125 6e-28
L12052-1|AAA35644.2| 482|Homo sapiens cAMP phosphodiesterase PD... 125 6e-28
BC126360-1|AAI26361.1| 456|Homo sapiens phosphodiesterase 7A pr... 125 6e-28
BC036319-1|AAH36319.1| 518|Homo sapiens PDE4D protein protein. 125 6e-28
AC005759-2|AAC83047.1| 710|Homo sapiens CN4C_HUMAN protein. 122 4e-27
AF332652-1|AAK57640.1| 424|Homo sapiens cAMP-specific cyclic nu... 119 5e-26
U85048-1|AAB96381.1| 721|Homo sapiens cyclic AMP specific phosp... 118 1e-25
M97515-1|AAA36426.1| 564|Homo sapiens phosphodiesterase protein. 118 1e-25
L20971-1|AAA03593.1| 564|Homo sapiens phosphodiesterase protein. 118 1e-25
L20966-1|AAA03589.1| 736|Homo sapiens phosphodiesterase protein. 118 1e-25
L12686-1|AAA35643.1| 606|Homo sapiens 3',5'-cyclic AMP phosphod... 118 1e-25
BC105040-1|AAI05041.1| 736|Homo sapiens phosphodiesterase 4B, c... 118 1e-25
BC101480-1|AAI01481.1| 736|Homo sapiens phosphodiesterase 4B, c... 118 1e-25
AL592285-3|CAH70628.1| 721|Homo sapiens phosphodiesterase 4B, c... 118 1e-25
AL592285-1|CAH70626.1| 736|Homo sapiens phosphodiesterase 4B, c... 118 1e-25
AL359701-3|CAI23101.1| 721|Homo sapiens phosphodiesterase 4B, c... 118 1e-25
AL359701-2|CAI23100.1| 564|Homo sapiens phosphodiesterase 4B, c... 118 1e-25
AL359701-1|CAI23099.1| 736|Homo sapiens phosphodiesterase 4B, c... 118 1e-25
AL357273-3|CAH73004.1| 721|Homo sapiens phosphodiesterase 4B, c... 118 1e-25
AL357273-1|CAH73002.1| 736|Homo sapiens phosphodiesterase 4B, c... 118 1e-25
AL109926-4|CAI21751.1| 721|Homo sapiens phosphodiesterase 4B, c... 118 1e-25
AL109926-3|CAI21750.1| 564|Homo sapiens phosphodiesterase 4B, c... 118 1e-25
AL109926-2|CAI21749.1| 736|Homo sapiens phosphodiesterase 4B, c... 118 1e-25
AB209081-1|BAD92318.1| 726|Homo sapiens phosphodiesterase 4B, c... 118 1e-25
EF108327-1|ABL14249.1| 502|Homo sapiens phosphodiesterase PDE7B... 117 2e-25
BC075083-1|AAH75083.1| 450|Homo sapiens phosphodiesterase 7B pr... 117 2e-25
BC075082-1|AAH75082.1| 450|Homo sapiens phosphodiesterase 7B pr... 117 2e-25
AL360178-1|CAH73075.1| 450|Homo sapiens phosphodiesterase 7B pr... 117 2e-25
AL138828-4|CAI95287.1| 450|Homo sapiens phosphodiesterase 7B pr... 117 2e-25
AL133319-1|CAH73332.1| 450|Homo sapiens phosphodiesterase 7B pr... 117 2e-25
AJ251860-1|CAB92441.1| 450|Homo sapiens phosphodiesterase 7B pr... 117 2e-25
AC073834-2|AAX93113.1| 125|Homo sapiens unknown protein. 117 2e-25
AB209990-1|BAE06072.1| 586|Homo sapiens PDE7B variant protein p... 117 2e-25
AB038040-1|BAA96537.1| 450|Homo sapiens cyclic nucleotide phosp... 117 2e-25
U18088-1|AAA98540.1| 323|Homo sapiens 3',5'-cyclic AMP phosphod... 116 3e-25
AF069491-4|AAC35014.1| 323|Homo sapiens cAMP specific phosphodi... 116 3e-25
BC075822-1|AAH75822.1| 829|Homo sapiens phosphodiesterase 8A pr... 109 4e-23
BC060762-1|AAH60762.1| 829|Homo sapiens phosphodiesterase 8A pr... 109 4e-23
AF388187-1|AAL18614.1| 582|Homo sapiens cAMP phosphodiesterase ... 109 4e-23
AF388186-1|AAL18613.1| 582|Homo sapiens cAMP phosphodiesterase ... 109 4e-23
AF388185-1|AAL18612.1| 449|Homo sapiens cAMP phosphodiesterase ... 109 4e-23
AF388184-1|AAL18611.1| 783|Homo sapiens cAMP phosphodiesterase ... 109 4e-23
AF388183-1|AAL18610.1| 829|Homo sapiens cAMP phosphodiesterase ... 109 4e-23
AF332653-1|AAK57641.1| 829|Homo sapiens cAMP-specific cyclic nu... 109 4e-23
AF056490-1|AAC39763.1| 713|Homo sapiens cAMP-specific phosphodi... 109 4e-23
BC048317-1|AAH48317.1| 305|Homo sapiens PDE8A protein protein. 103 4e-21
BC035144-1|AAH35144.1| 385|Homo sapiens PDE8B protein protein. 100 2e-20
AY423729-1|AAS00492.1| 350|Homo sapiens proliferation-inducing ... 100 2e-20
AY129950-3|AAN71727.1| 788|Homo sapiens cAMP-specific phosphodi... 100 2e-20
AY129950-2|AAN71726.1| 838|Homo sapiens cAMP-specific phosphodi... 100 2e-20
AY129950-1|AAN71725.1| 885|Homo sapiens cAMP-specific phosphodi... 100 2e-20
AY129949-1|AAN71724.1| 788|Homo sapiens cAMP-specific phosphodi... 100 2e-20
AY129948-1|AAN71723.1| 838|Homo sapiens cAMP-specific phosphodi... 100 2e-20
AL831924-1|CAD38584.1| 843|Homo sapiens hypothetical protein pr... 100 2e-20
AF079529-1|AAC69564.2| 885|Homo sapiens cAMP-specific phosphodi... 100 2e-20
AB085827-1|BAC53765.1| 865|Homo sapiens phosphodiesterase 8B4 p... 100 2e-20
AB085826-1|BAC53764.1| 830|Homo sapiens phosphodiesterase 8B3 p... 100 2e-20
AB085825-1|BAC53763.1| 788|Homo sapiens phosphodiestearse 8B2 p... 100 2e-20
AB085824-1|BAC53762.1| 885|Homo sapiens phosphodiesterase 8B1 p... 100 2e-20
U36798-1|AAB18673.1| 1141|Homo sapiens platelet cGI-PDE protein. 93 4e-18
M91667-1|AAA35912.2| 1141|Homo sapiens cGMP-inhibited cAMP phosp... 93 4e-18
BC117371-1|AAI17372.1| 1141|Homo sapiens phosphodiesterase 3A, c... 93 4e-18
BC117369-1|AAI17370.1| 1141|Homo sapiens phosphodiesterase 3A, c... 93 4e-18
AJ005036-1|CAA06304.1| 1141|Homo sapiens phosphodiesterase 3A pr... 93 4e-18
U66349-1|AAB96878.1| 427|Homo sapiens PDE4C-delta109 protein. 91 1e-17
AC005759-4|AAC83048.1| 427|Homo sapiens PDE4C-delta109 protein. 91 1e-17
U40584-1|AAB50018.1| 184|Homo sapiens calcium/calmodulin-stimul... 90 4e-17
X95520-1|CAA64774.1| 1112|Homo sapiens cyclic nucleotide phospho... 88 1e-16
U38178-1|AAC50724.1| 1112|Homo sapiens cyclic nucleotide phophod... 88 1e-16
D50640-1|BAA09306.1| 1112|Homo sapiens phosphodiesterase 3B prot... 88 1e-16
AY459346-1|AAR24292.1| 1112|Homo sapiens cGMP-inhibited cAMP pho... 88 1e-16
AC073892-1|AAY24130.1| 98|Homo sapiens unknown protein. 85 1e-15
M94539-1|AAA58405.1| 116|Homo sapiens cyclic nucleotide phospho... 83 4e-15
AY266363-1|AAP31235.1| 255|Homo sapiens phosphodiesterase isozy... 83 4e-15
BC047627-1|AAH47627.1| 241|Homo sapiens PDE8B protein protein. 82 9e-15
AL138828-3|CAI95286.1| 199|Homo sapiens phosphodiesterase 7B pr... 66 4e-10
U86077-1|AAC51871.1| 71|Homo sapiens calmodulin-stimulated pho... 59 6e-08
L20968-1|AAA03591.1| 251|Homo sapiens phosphodiesterase protein. 49 6e-05
AL109778-1|CAB52432.1| 178|Homo sapiens PDE8A; phosphodiesteras... 47 3e-04
AY266362-1|AAP31234.1| 102|Homo sapiens phosphodiesterase isozy... 41 0.021
AL109687-1|CAB52020.1| 160|Homo sapiens PDE8A; phosphodiesteras... 41 0.021
X62693-1|CAA44570.1| 51|Homo sapiens cGMP phosphodiesterase b... 34 1.9
AF071787-1|AAC80000.1| 1533|Homo sapiens melastatin 1 protein. 33 5.7
AB115502-1|BAC80204.1| 1527|Homo sapiens melastatin 1 splicing v... 33 5.7
AB115501-1|BAC80203.1| 1533|Homo sapiens melastatin 1 protein. 33 5.7
AB115499-1|BAC80201.1| 1533|Homo sapiens melastatin 1 protein. 33 5.7
AB115498-1|BAC80200.1| 1533|Homo sapiens melastatin 1 protein. 33 5.7
X91625-1|CAA62823.1| 383|Homo sapiens MHC class I antigen protein. 32 7.5
>D89094-1|BAA28945.1| 875|Homo sapiens 3',5'-cyclic GMP
phosphodiesterase protein.
Length = 875
Score = 492 bits (1214), Expect = e-138
Identities = 258/584 (44%), Positives = 348/584 (59%), Gaps = 13/584 (2%)
Query: 138 LRRKLSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFE 197
+ +K + G+ F+ +D + F YL FCGI + NAQL+E+S+LE KRNQ+LL LA IFE
Sbjct: 285 INKKSGNGGT--FTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE 342
Query: 198 EQSNLECLVTKIMTEARDLLKCERCAVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXX 257
EQ +LE ++ KI ++ ++C +FI+D D C S
Sbjct: 343 EQQSLEVILKKIAATIISFMQVQKCTIFIVDED-CSDSFSSVFHMECEELEKSSDTLTRE 401
Query: 258 XXXXXXXXTRFHTVFELGAPRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGEN 317
V P D N N++ +Q +R + +N
Sbjct: 402 HDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG-NVN--QQCIRSLLCTPIKN 458
Query: 318 SAGVRTLLCMPIVNANKDVIGVAQLINKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKL 377
+ + +VN ++ G + F D EAF IFCGLGI NTQMYE +
Sbjct: 459 GKKNKVIGVCQLVNKMEENTG---KVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERA 515
Query: 378 MAKQKVALECLSYHATASAEDT---SKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRAT 434
MAKQ V LE LSYHA+A+ E+T L +PSA+T + F F DF+L+D +T T
Sbjct: 516 MAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCT 575
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKME 493
+RMF LV+ F + ++VLCRWILSVKKNYR V YHNWRHA N AQ MFA LK GK++
Sbjct: 576 IRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ 635
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTSTMEHHHFDQCVMILNS 553
++DLEIL LL+A L HDLDHRG NN++ ++E PLA LY S MEHHHFDQC+MILNS
Sbjct: 636 NKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNS 695
Query: 554 ESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELL 613
N I LS +YK + +++ AIL+TDLA+Y K++ +F EL+ +F+ + +KEL
Sbjct: 696 PGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELF 755
Query: 614 CGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQ 673
M+MTACD+SAI KPW +Q RIA+LVA EFFDQGD E+ +LN +P +M+REKK+++P
Sbjct: 756 LAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPS 815
Query: 674 MQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
MQVGFID ICL LY+ L+ PL G NR++WQ LAE+
Sbjct: 816 MQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
Score = 68.5 bits (160), Expect = 9e-11
Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 15/198 (7%)
Query: 291 VARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK----- 345
VA + LNI D + R N +++LCMPI N ++V+GVAQ INK
Sbjct: 233 VAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNG 292
Query: 346 --FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSKLC 403
FTE D F A+ FCG+ +HN Q+YE + + +V L+ S + + ++
Sbjct: 293 GTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLAS--LIFEEQQSLEVI 350
Query: 404 QDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF-LQCELVEKFHIPYDVLCRWILSVK 462
+I +A + Q + DED + +F ++CE +EK D L R + K
Sbjct: 351 LKKI-AATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEK---SSDTLTREHDANK 406
Query: 463 KNYRPVKY-HNWRHALNV 479
NY +Y N LN+
Sbjct: 407 INYMYAQYVKNTMEPLNI 424
Score = 59.7 bits (138), Expect = 4e-08
Identities = 28/50 (56%), Positives = 35/50 (70%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLD 104
+FN+E+D TGYKT+ ILCMPI N+ +VVGVAQ INK G T + D
Sbjct: 250 RFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKD 299
>BC126233-1|AAI26234.1| 875|Homo sapiens phosphodiesterase 5A,
cGMP-specific protein.
Length = 875
Score = 492 bits (1214), Expect = e-138
Identities = 258/584 (44%), Positives = 348/584 (59%), Gaps = 13/584 (2%)
Query: 138 LRRKLSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFE 197
+ +K + G+ F+ +D + F YL FCGI + NAQL+E+S+LE KRNQ+LL LA IFE
Sbjct: 285 INKKSGNGGT--FTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE 342
Query: 198 EQSNLECLVTKIMTEARDLLKCERCAVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXX 257
EQ +LE ++ KI ++ ++C +FI+D D C S
Sbjct: 343 EQQSLEVILKKIAATIISFMQVQKCTIFIVDED-CSDSFSSVFHMECEELEKSSDTLTRE 401
Query: 258 XXXXXXXXTRFHTVFELGAPRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGEN 317
V P D N N++ +Q +R + +N
Sbjct: 402 HDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG-NVN--QQCIRSLLCTPIKN 458
Query: 318 SAGVRTLLCMPIVNANKDVIGVAQLINKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKL 377
+ + +VN ++ G + F D EAF IFCGLGI NTQMYE +
Sbjct: 459 GKKNKVIGVCQLVNKMEENTG---KVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERA 515
Query: 378 MAKQKVALECLSYHATASAEDT---SKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRAT 434
MAKQ V LE LSYHA+A+ E+T L +PSA+T + F F DF+L+D +T T
Sbjct: 516 MAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCT 575
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKME 493
+RMF LV+ F + ++VLCRWILSVKKNYR V YHNWRHA N AQ MFA LK GK++
Sbjct: 576 IRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ 635
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTSTMEHHHFDQCVMILNS 553
++DLEIL LL+A L HDLDHRG NN++ ++E PLA LY S MEHHHFDQC+MILNS
Sbjct: 636 NKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNS 695
Query: 554 ESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELL 613
N I LS +YK + +++ AIL+TDLA+Y K++ +F EL+ +F+ + +KEL
Sbjct: 696 PGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELF 755
Query: 614 CGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQ 673
M+MTACD+SAI KPW +Q RIA+LVA EFFDQGD E+ +LN +P +M+REKK+++P
Sbjct: 756 LAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPS 815
Query: 674 MQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
MQVGFID ICL LY+ L+ PL G NR++WQ LAE+
Sbjct: 816 MQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
Score = 68.5 bits (160), Expect = 9e-11
Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 15/198 (7%)
Query: 291 VARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK----- 345
VA + LNI D + R N +++LCMPI N ++V+GVAQ INK
Sbjct: 233 VAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNG 292
Query: 346 --FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSKLC 403
FTE D F A+ FCG+ +HN Q+YE + + +V L+ S + + ++
Sbjct: 293 GTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLAS--LIFEEQQSLEVI 350
Query: 404 QDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF-LQCELVEKFHIPYDVLCRWILSVK 462
+I +A + Q + DED + +F ++CE +EK D L R + K
Sbjct: 351 LKKI-AATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEK---SSDTLTREHDANK 406
Query: 463 KNYRPVKY-HNWRHALNV 479
NY +Y N LN+
Sbjct: 407 INYMYAQYVKNTMEPLNI 424
Score = 59.7 bits (138), Expect = 4e-08
Identities = 28/50 (56%), Positives = 35/50 (70%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLD 104
+FN+E+D TGYKT+ ILCMPI N+ +VVGVAQ INK G T + D
Sbjct: 250 RFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKD 299
>AY264918-1|AAP21809.1| 833|Homo sapiens phosphodiesterase 5A
protein.
Length = 833
Score = 492 bits (1214), Expect = e-138
Identities = 258/584 (44%), Positives = 348/584 (59%), Gaps = 13/584 (2%)
Query: 138 LRRKLSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFE 197
+ +K + G+ F+ +D + F YL FCGI + NAQL+E+S+LE KRNQ+LL LA IFE
Sbjct: 243 INKKSGNGGT--FTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE 300
Query: 198 EQSNLECLVTKIMTEARDLLKCERCAVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXX 257
EQ +LE ++ KI ++ ++C +FI+D D C S
Sbjct: 301 EQQSLEVILKKIAATIISFMQVQKCTIFIVDED-CSDSFSSVFHMECEELEKSSDTLTRE 359
Query: 258 XXXXXXXXTRFHTVFELGAPRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGEN 317
V P D N N++ +Q +R + +N
Sbjct: 360 HDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG-NVN--QQCIRSLLCTPIKN 416
Query: 318 SAGVRTLLCMPIVNANKDVIGVAQLINKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKL 377
+ + +VN ++ G + F D EAF IFCGLGI NTQMYE +
Sbjct: 417 GKKNKVIGVCQLVNKMEENTG---KVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERA 473
Query: 378 MAKQKVALECLSYHATASAEDT---SKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRAT 434
MAKQ V LE LSYHA+A+ E+T L +PSA+T + F F DF+L+D +T T
Sbjct: 474 MAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCT 533
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKME 493
+RMF LV+ F + ++VLCRWILSVKKNYR V YHNWRHA N AQ MFA LK GK++
Sbjct: 534 IRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ 593
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTSTMEHHHFDQCVMILNS 553
++DLEIL LL+A L HDLDHRG NN++ ++E PLA LY S MEHHHFDQC+MILNS
Sbjct: 594 NKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNS 653
Query: 554 ESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELL 613
N I LS +YK + +++ AIL+TDLA+Y K++ +F EL+ +F+ + +KEL
Sbjct: 654 PGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELF 713
Query: 614 CGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQ 673
M+MTACD+SAI KPW +Q RIA+LVA EFFDQGD E+ +LN +P +M+REKK+++P
Sbjct: 714 LAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPS 773
Query: 674 MQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
MQVGFID ICL LY+ L+ PL G NR++WQ LAE+
Sbjct: 774 MQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 817
Score = 68.5 bits (160), Expect = 9e-11
Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 15/198 (7%)
Query: 291 VARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK----- 345
VA + LNI D + R N +++LCMPI N ++V+GVAQ INK
Sbjct: 191 VAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNG 250
Query: 346 --FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSKLC 403
FTE D F A+ FCG+ +HN Q+YE + + +V L+ S + + ++
Sbjct: 251 GTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLAS--LIFEEQQSLEVI 308
Query: 404 QDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF-LQCELVEKFHIPYDVLCRWILSVK 462
+I +A + Q + DED + +F ++CE +EK D L R + K
Sbjct: 309 LKKI-AATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEK---SSDTLTREHDANK 364
Query: 463 KNYRPVKY-HNWRHALNV 479
NY +Y N LN+
Sbjct: 365 INYMYAQYVKNTMEPLNI 382
Score = 59.7 bits (138), Expect = 4e-08
Identities = 28/50 (56%), Positives = 35/50 (70%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLD 104
+FN+E+D TGYKT+ ILCMPI N+ +VVGVAQ INK G T + D
Sbjct: 208 RFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKD 257
>AJ004865-1|CAA06170.1| 875|Homo sapiens cGMP-binding,
cGMP-specific phosphodiesterase (HSPDE5A1) protein.
Length = 875
Score = 492 bits (1214), Expect = e-138
Identities = 258/584 (44%), Positives = 348/584 (59%), Gaps = 13/584 (2%)
Query: 138 LRRKLSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFE 197
+ +K + G+ F+ +D + F YL FCGI + NAQL+E+S+LE KRNQ+LL LA IFE
Sbjct: 285 INKKSGNGGT--FTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE 342
Query: 198 EQSNLECLVTKIMTEARDLLKCERCAVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXX 257
EQ +LE ++ KI ++ ++C +FI+D D C S
Sbjct: 343 EQQSLEVILKKIAATIISFMQVQKCTIFIVDED-CSDSFSSVFHMECEELEKSSDTLTRE 401
Query: 258 XXXXXXXXTRFHTVFELGAPRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGEN 317
V P D N N++ +Q +R + +N
Sbjct: 402 HDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG-NVN--QQCIRSLLCTPIKN 458
Query: 318 SAGVRTLLCMPIVNANKDVIGVAQLINKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKL 377
+ + +VN ++ G + F D EAF IFCGLGI NTQMYE +
Sbjct: 459 GKKNKVIGVCQLVNKMEENTG---KVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERA 515
Query: 378 MAKQKVALECLSYHATASAEDT---SKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRAT 434
MAKQ V LE LSYHA+A+ E+T L +PSA+T + F F DF+L+D +T T
Sbjct: 516 MAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCT 575
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKME 493
+RMF LV+ F + ++VLCRWILSVKKNYR V YHNWRHA N AQ MFA LK GK++
Sbjct: 576 IRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ 635
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTSTMEHHHFDQCVMILNS 553
++DLEIL LL+A L HDLDHRG NN++ ++E PLA LY S MEHHHFDQC+MILNS
Sbjct: 636 NKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNS 695
Query: 554 ESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELL 613
N I LS +YK + +++ AIL+TDLA+Y K++ +F EL+ +F+ + +KEL
Sbjct: 696 PGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELF 755
Query: 614 CGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQ 673
M+MTACD+SAI KPW +Q RIA+LVA EFFDQGD E+ +LN +P +M+REKK+++P
Sbjct: 756 LAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPS 815
Query: 674 MQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
MQVGFID ICL LY+ L+ PL G NR++WQ LAE+
Sbjct: 816 MQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
Score = 68.5 bits (160), Expect = 9e-11
Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 15/198 (7%)
Query: 291 VARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK----- 345
VA + LNI D + R N +++LCMPI N ++V+GVAQ INK
Sbjct: 233 VAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNG 292
Query: 346 --FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSKLC 403
FTE D F A+ FCG+ +HN Q+YE + + +V L+ S + + ++
Sbjct: 293 GTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLAS--LIFEEQQSLEVI 350
Query: 404 QDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF-LQCELVEKFHIPYDVLCRWILSVK 462
+I +A + Q + DED + +F ++CE +EK D L R + K
Sbjct: 351 LKKI-AATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEK---SSDTLTREHDANK 406
Query: 463 KNYRPVKY-HNWRHALNV 479
NY +Y N LN+
Sbjct: 407 INYMYAQYVKNTMEPLNI 424
Score = 59.7 bits (138), Expect = 4e-08
Identities = 28/50 (56%), Positives = 35/50 (70%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLD 104
+FN+E+D TGYKT+ ILCMPI N+ +VVGVAQ INK G T + D
Sbjct: 250 RFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKD 299
>AF043731-1|AAC63967.1| 875|Homo sapiens cGMP-binding cGMP-specific
3',5'-cyclic nucleotide phosphodiesterase protein.
Length = 875
Score = 492 bits (1214), Expect = e-138
Identities = 258/584 (44%), Positives = 348/584 (59%), Gaps = 13/584 (2%)
Query: 138 LRRKLSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFE 197
+ +K + G+ F+ +D + F YL FCGI + NAQL+E+S+LE KRNQ+LL LA IFE
Sbjct: 285 INKKSGNGGT--FTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE 342
Query: 198 EQSNLECLVTKIMTEARDLLKCERCAVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXX 257
EQ +LE ++ KI ++ ++C +FI+D D C S
Sbjct: 343 EQQSLEVILKKIAATIISFMQVQKCTIFIVDED-CSDSFSSVFHMECEELEKSSDTLTRE 401
Query: 258 XXXXXXXXTRFHTVFELGAPRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGEN 317
V P D N N++ +Q +R + +N
Sbjct: 402 HDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG-NVN--QQCIRSLLCTPIKN 458
Query: 318 SAGVRTLLCMPIVNANKDVIGVAQLINKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKL 377
+ + +VN ++ G + F D EAF IFCGLGI NTQMYE +
Sbjct: 459 GKKNKVIGVCQLVNKMEENTG---KVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERA 515
Query: 378 MAKQKVALECLSYHATASAEDT---SKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRAT 434
MAKQ V LE LSYHA+A+ E+T L +PSA+T + F F DF+L+D +T T
Sbjct: 516 MAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCT 575
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKME 493
+RMF LV+ F + ++VLCRWILSVKKNYR V YHNWRHA N AQ MFA LK GK++
Sbjct: 576 IRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ 635
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTSTMEHHHFDQCVMILNS 553
++DLEIL LL+A L HDLDHRG NN++ ++E PLA LY S MEHHHFDQC+MILNS
Sbjct: 636 NKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNS 695
Query: 554 ESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELL 613
N I LS +YK + +++ AIL+TDLA+Y K++ +F EL+ +F+ + +KEL
Sbjct: 696 PGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELF 755
Query: 614 CGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQ 673
M+MTACD+SAI KPW +Q RIA+LVA EFFDQGD E+ +LN +P +M+REKK+++P
Sbjct: 756 LAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPS 815
Query: 674 MQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
MQVGFID ICL LY+ L+ PL G NR++WQ LAE+
Sbjct: 816 MQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
Score = 68.5 bits (160), Expect = 9e-11
Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 15/198 (7%)
Query: 291 VARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK----- 345
VA + LNI D + R N +++LCMPI N ++V+GVAQ INK
Sbjct: 233 VAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNG 292
Query: 346 --FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSKLC 403
FTE D F A+ FCG+ +HN Q+YE + + +V L+ S + + ++
Sbjct: 293 GTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLAS--LIFEEQQSLEVI 350
Query: 404 QDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF-LQCELVEKFHIPYDVLCRWILSVK 462
+I +A + Q + DED + +F ++CE +EK D L R + K
Sbjct: 351 LKKI-AATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEK---SSDTLTREHDANK 406
Query: 463 KNYRPVKY-HNWRHALNV 479
NY +Y N LN+
Sbjct: 407 INYMYAQYVKNTMEPLNI 424
Score = 59.7 bits (138), Expect = 4e-08
Identities = 28/50 (56%), Positives = 35/50 (70%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLD 104
+FN+E+D TGYKT+ ILCMPI N+ +VVGVAQ INK G T + D
Sbjct: 250 RFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKD 299
>AB001635-1|BAA33372.2| 875|Homo sapiens cGMP-binding cGMP-specific
phosphodiesterase protein.
Length = 875
Score = 492 bits (1214), Expect = e-138
Identities = 258/584 (44%), Positives = 348/584 (59%), Gaps = 13/584 (2%)
Query: 138 LRRKLSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFE 197
+ +K + G+ F+ +D + F YL FCGI + NAQL+E+S+LE KRNQ+LL LA IFE
Sbjct: 285 INKKSGNGGT--FTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE 342
Query: 198 EQSNLECLVTKIMTEARDLLKCERCAVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXX 257
EQ +LE ++ KI ++ ++C +FI+D D C S
Sbjct: 343 EQQSLEVILKKIAATIISFMQVQKCTIFIVDED-CSDSFSSVFHMECEELEKSSDTLTRE 401
Query: 258 XXXXXXXXTRFHTVFELGAPRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGEN 317
V P D N N++ +Q +R + +N
Sbjct: 402 HDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG-NVN--QQCIRSLLCTPIKN 458
Query: 318 SAGVRTLLCMPIVNANKDVIGVAQLINKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKL 377
+ + +VN ++ G + F D EAF IFCGLGI NTQMYE +
Sbjct: 459 GKKNKVIGVCQLVNKMEENTG---KVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERA 515
Query: 378 MAKQKVALECLSYHATASAEDT---SKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRAT 434
MAKQ V LE LSYHA+A+ E+T L +PSA+T + F F DF+L+D +T T
Sbjct: 516 MAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCT 575
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKME 493
+RMF LV+ F + ++VLCRWILSVKKNYR V YHNWRHA N AQ MFA LK GK++
Sbjct: 576 IRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ 635
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTSTMEHHHFDQCVMILNS 553
++DLEIL LL+A L HDLDHRG NN++ ++E PLA LY S MEHHHFDQC+MILNS
Sbjct: 636 NKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNS 695
Query: 554 ESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELL 613
N I LS +YK + +++ AIL+TDLA+Y K++ +F EL+ +F+ + +KEL
Sbjct: 696 PGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELF 755
Query: 614 CGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQ 673
M+MTACD+SAI KPW +Q RIA+LVA EFFDQGD E+ +LN +P +M+REKK+++P
Sbjct: 756 LAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPS 815
Query: 674 MQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
MQVGFID ICL LY+ L+ PL G NR++WQ LAE+
Sbjct: 816 MQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 859
Score = 68.5 bits (160), Expect = 9e-11
Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 15/198 (7%)
Query: 291 VARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK----- 345
VA + LNI D + R N +++LCMPI N ++V+GVAQ INK
Sbjct: 233 VAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNG 292
Query: 346 --FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSKLC 403
FTE D F A+ FCG+ +HN Q+YE + + +V L+ S + + ++
Sbjct: 293 GTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLAS--LIFEEQQSLEVI 350
Query: 404 QDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF-LQCELVEKFHIPYDVLCRWILSVK 462
+I +A + Q + DED + +F ++CE +EK D L R + K
Sbjct: 351 LKKI-AATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEK---SSDTLTREHDANK 406
Query: 463 KNYRPVKY-HNWRHALNV 479
NY +Y N LN+
Sbjct: 407 INYMYAQYVKNTMEPLNI 424
Score = 59.7 bits (138), Expect = 4e-08
Identities = 28/50 (56%), Positives = 35/50 (70%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLD 104
+FN+E+D TGYKT+ ILCMPI N+ +VVGVAQ INK G T + D
Sbjct: 250 RFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKD 299
>AB015656-1|BAA81667.1| 833|Homo sapiens cGMP-binding cGMP specific
phosphodiesterase 5A2 protein.
Length = 833
Score = 489 bits (1207), Expect = e-137
Identities = 257/584 (44%), Positives = 347/584 (59%), Gaps = 13/584 (2%)
Query: 138 LRRKLSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFE 197
+ +K + G+ F+ +D + F YL FCGI + NAQL+E+S+LE KRNQ+LL LA IFE
Sbjct: 243 INKKSGNGGT--FTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE 300
Query: 198 EQSNLECLVTKIMTEARDLLKCERCAVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXX 257
EQ +LE ++ KI ++ ++C +FI+D D C S
Sbjct: 301 EQQSLEVILKKIAATIISFMQVQKCTIFIVDED-CSDSFSSVFHMECEELEKSSDTLTRE 359
Query: 258 XXXXXXXXTRFHTVFELGAPRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGEN 317
V P D N N++ +Q +R + +N
Sbjct: 360 HDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG-NVN--QQCIRSLLCTPIKN 416
Query: 318 SAGVRTLLCMPIVNANKDVIGVAQLINKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKL 377
+ + +VN ++ G + F D EAF IFCGLGI NTQMYE +
Sbjct: 417 GKKNKVIGVCQLVNKMEENTG---KVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERA 473
Query: 378 MAKQKVALECLSYHATASAEDT---SKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRAT 434
MAKQ V LE LSYHA+A+ E+T L +PSA+T + F F DF+L+D +T T
Sbjct: 474 MAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCT 533
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKME 493
+RMF LV+ F + ++VLCRWILSVKKNYR V YHNWRHA N AQ MFA LK GK++
Sbjct: 534 IRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ 593
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTSTMEHHHFDQCVMILNS 553
++DL IL LL+A L HDLDHRG NN++ ++E PLA LY S MEHHHFDQC+MILNS
Sbjct: 594 NKLTDLGILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNS 653
Query: 554 ESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELL 613
N I LS +YK + +++ AIL+TDLA+Y K++ +F EL+ +F+ + +KEL
Sbjct: 654 PGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELF 713
Query: 614 CGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQ 673
M+MTACD+SAI KPW +Q RIA+LVA EFFDQGD E+ +LN +P +M+REKK+++P
Sbjct: 714 LAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPS 773
Query: 674 MQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
MQVGFID ICL LY+ L+ PL G NR++WQ LAE+
Sbjct: 774 MQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ 817
Score = 68.5 bits (160), Expect = 9e-11
Identities = 60/198 (30%), Positives = 92/198 (46%), Gaps = 15/198 (7%)
Query: 291 VARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK----- 345
VA + LNI D + R N +++LCMPI N ++V+GVAQ INK
Sbjct: 191 VAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNG 250
Query: 346 --FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSKLC 403
FTE D F A+ FCG+ +HN Q+YE + + +V L+ S + + ++
Sbjct: 251 GTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLAS--LIFEEQQSLEVI 308
Query: 404 QDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF-LQCELVEKFHIPYDVLCRWILSVK 462
+I +A + Q + DED + +F ++CE +EK D L R + K
Sbjct: 309 LKKI-AATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEK---SSDTLTREHDANK 364
Query: 463 KNYRPVKY-HNWRHALNV 479
NY +Y N LN+
Sbjct: 365 INYMYAQYVKNTMEPLNI 382
Score = 59.7 bits (138), Expect = 4e-08
Identities = 28/50 (56%), Positives = 35/50 (70%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLD 104
+FN+E+D TGYKT+ ILCMPI N+ +VVGVAQ INK G T + D
Sbjct: 208 RFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKD 257
>BC114431-1|AAI14432.1| 934|Homo sapiens phosphodiesterase 11A
protein.
Length = 934
Score = 450 bits (1109), Expect = e-125
Identities = 242/580 (41%), Positives = 339/580 (58%), Gaps = 31/580 (5%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+ D +V + YL FCGI I NAQ L A +R +E L +V +
Sbjct: 351 FTEDDEKVMQMYLPFCGIAISNAQ--------------LFAASRKEYERSRALLEVVNDL 396
Query: 210 MTEARDLLKCERC----AVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXX 265
E DL K + A +L + C LE I
Sbjct: 397 FEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDI--ESPVVKFTKSFELMSPKCSADAE 454
Query: 266 TRFHTVFELGAPRRPHDAL--PAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRT 323
F E + D L +IA VA + +NISD Q R + + + +R+
Sbjct: 455 NSFKESMEKSSYS---DWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRS 511
Query: 324 LLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLM 378
+LC+PI N+N +IGVAQ++N+ F + D +FEAF IFCGLGI+NT MY+ K
Sbjct: 512 VLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSW 571
Query: 379 AKQKVALECLSYHATASAEDTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF 438
AKQ VAL+ LSYHAT S + K IP + F DF L + A LRMF
Sbjct: 572 AKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMF 631
Query: 439 LQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSD 498
++ +V+KF I Y+ LCRW+L+V+KNYR V YHNWRHA NV Q MFAML T + +++
Sbjct: 632 MELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTE 691
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTS-TMEHHHFDQCVMILNSESNN 557
+EIL ++V CLCHDLDHRGTNNAFQ K+ S LA LY TS T+EHHHF+ VMIL SE +N
Sbjct: 692 VEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHN 751
Query: 558 IFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMM 617
IF LS ++Y D+M +++ +IL+TDL +YF+++++F ELV GE+DW + +++ M+
Sbjct: 752 IFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSML 811
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
MTACD+ A+ KPWE+ ++A+LV EFF+QGD E+L+L P A+ DR +KDELP++Q+
Sbjct: 812 MTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE 871
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
+ID+IC+PLY+ L + P+ A NR +W++L +K
Sbjct: 872 WIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 911
Score = 60.1 bits (139), Expect = 3e-08
Identities = 34/105 (32%), Positives = 56/105 (53%), Gaps = 6/105 (5%)
Query: 291 VARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK----- 345
V +++NI D Q R N+ ++LLCMPI +++ ++IGVAQ INK
Sbjct: 290 VGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGA 349
Query: 346 -FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLS 389
FTE D + + + FCG+ I N Q++ + K + + LE ++
Sbjct: 350 PFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVN 394
Score = 56.0 bits (129), Expect = 5e-07
Identities = 26/47 (55%), Positives = 35/47 (74%), Gaps = 1/47 (2%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINK-TDGEHTTE 100
+FN EID TGYKT+ +LCMPI + +G+++GVAQ INK +G TE
Sbjct: 307 RFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTE 353
Score = 44.0 bits (99), Expect = 0.002
Identities = 16/42 (38%), Positives = 29/42 (69%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+F++E D +G+ +LC+PI N ++GVAQ++N+ DG+
Sbjct: 496 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 537
Score = 32.3 bits (70), Expect = 7.5
Identities = 12/48 (25%), Positives = 23/48 (47%)
Query: 142 LSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILL 189
L+ K F D +F ++ FCG+GI N +++ + + + L
Sbjct: 531 LNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 578
>BC112393-1|AAI12394.1| 934|Homo sapiens phosphodiesterase 11A
protein.
Length = 934
Score = 450 bits (1109), Expect = e-125
Identities = 242/580 (41%), Positives = 339/580 (58%), Gaps = 31/580 (5%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+ D +V + YL FCGI I NAQ L A +R +E L +V +
Sbjct: 351 FTEDDEKVMQMYLPFCGIAISNAQ--------------LFAASRKEYERSRALLEVVNDL 396
Query: 210 MTEARDLLKCERC----AVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXX 265
E DL K + A +L + C LE I
Sbjct: 397 FEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDI--ESPVVKFTKSFELMSPKCSADAE 454
Query: 266 TRFHTVFELGAPRRPHDAL--PAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRT 323
F E + D L +IA VA + +NISD Q R + + + +R+
Sbjct: 455 NSFKESMEKSSYS---DWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRS 511
Query: 324 LLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLM 378
+LC+PI N+N +IGVAQ++N+ F + D +FEAF IFCGLGI+NT MY+ K
Sbjct: 512 VLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSW 571
Query: 379 AKQKVALECLSYHATASAEDTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF 438
AKQ VAL+ LSYHAT S + K IP + F DF L + A LRMF
Sbjct: 572 AKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMF 631
Query: 439 LQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSD 498
++ +V+KF I Y+ LCRW+L+V+KNYR V YHNWRHA NV Q MFAML T + +++
Sbjct: 632 MELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTE 691
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTS-TMEHHHFDQCVMILNSESNN 557
+EIL ++V CLCHDLDHRGTNNAFQ K+ S LA LY TS T+EHHHF+ VMIL SE +N
Sbjct: 692 VEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHN 751
Query: 558 IFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMM 617
IF LS ++Y D+M +++ +IL+TDL +YF+++++F ELV GE+DW + +++ M+
Sbjct: 752 IFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSML 811
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
MTACD+ A+ KPWE+ ++A+LV EFF+QGD E+L+L P A+ DR +KDELP++Q+
Sbjct: 812 MTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE 871
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
+ID+IC+PLY+ L + P+ A NR +W++L +K
Sbjct: 872 WIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 911
Score = 60.1 bits (139), Expect = 3e-08
Identities = 34/105 (32%), Positives = 56/105 (53%), Gaps = 6/105 (5%)
Query: 291 VARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK----- 345
V +++NI D Q R N+ ++LLCMPI +++ ++IGVAQ INK
Sbjct: 290 VGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGA 349
Query: 346 -FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLS 389
FTE D + + + FCG+ I N Q++ + K + + LE ++
Sbjct: 350 PFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVN 394
Score = 56.0 bits (129), Expect = 5e-07
Identities = 26/47 (55%), Positives = 35/47 (74%), Gaps = 1/47 (2%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINK-TDGEHTTE 100
+FN EID TGYKT+ +LCMPI + +G+++GVAQ INK +G TE
Sbjct: 307 RFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTE 353
Score = 44.0 bits (99), Expect = 0.002
Identities = 16/42 (38%), Positives = 29/42 (69%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+F++E D +G+ +LC+PI N ++GVAQ++N+ DG+
Sbjct: 496 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 537
Score = 32.3 bits (70), Expect = 7.5
Identities = 12/48 (25%), Positives = 23/48 (47%)
Query: 142 LSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILL 189
L+ K F D +F ++ FCG+GI N +++ + + + L
Sbjct: 531 LNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 578
>AJ278682-1|CAC15567.1| 684|Homo sapiens cAMP/cGMP cyclic
nucleotide phosphodiesterase 11A3 protein.
Length = 684
Score = 450 bits (1109), Expect = e-125
Identities = 242/580 (41%), Positives = 339/580 (58%), Gaps = 31/580 (5%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+ D +V + YL FCGI I NAQ L A +R +E L +V +
Sbjct: 101 FTEDDEKVMQMYLPFCGIAISNAQ--------------LFAASRKEYERSRALLEVVNDL 146
Query: 210 MTEARDLLKCERC----AVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXX 265
E DL K + A +L + C LE I
Sbjct: 147 FEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDI--ESPVVKFTKSFELMSPKCSADAE 204
Query: 266 TRFHTVFELGAPRRPHDAL--PAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRT 323
F E + D L +IA VA + +NISD Q R + + + +R+
Sbjct: 205 NSFKESMEKSSYS---DWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRS 261
Query: 324 LLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLM 378
+LC+PI N+N +IGVAQ++N+ F + D +FEAF IFCGLGI+NT MY+ K
Sbjct: 262 VLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSW 321
Query: 379 AKQKVALECLSYHATASAEDTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF 438
AKQ VAL+ LSYHAT S + K IP + F DF L + A LRMF
Sbjct: 322 AKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMF 381
Query: 439 LQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSD 498
++ +V+KF I Y+ LCRW+L+V+KNYR V YHNWRHA NV Q MFAML T + +++
Sbjct: 382 MELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTE 441
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTS-TMEHHHFDQCVMILNSESNN 557
+EIL ++V CLCHDLDHRGTNNAFQ K+ S LA LY TS T+EHHHF+ VMIL SE +N
Sbjct: 442 VEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHN 501
Query: 558 IFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMM 617
IF LS ++Y D+M +++ +IL+TDL +YF+++++F ELV GE+DW + +++ M+
Sbjct: 502 IFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSML 561
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
MTACD+ A+ KPWE+ ++A+LV EFF+QGD E+L+L P A+ DR +KDELP++Q+
Sbjct: 562 MTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE 621
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
+ID+IC+PLY+ L + P+ A NR +W++L +K
Sbjct: 622 WIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 661
Score = 56.0 bits (129), Expect = 5e-07
Identities = 26/47 (55%), Positives = 35/47 (74%), Gaps = 1/47 (2%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINK-TDGEHTTE 100
+FN EID TGYKT+ +LCMPI + +G+++GVAQ INK +G TE
Sbjct: 57 RFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTE 103
Score = 55.2 bits (127), Expect = 9e-07
Identities = 27/74 (36%), Positives = 45/74 (60%), Gaps = 6/74 (8%)
Query: 322 RTLLCMPIVNANKDVIGVAQLINK------FTEGDVSIFEAFAIFCGLGIHNTQMYENAC 375
++LLCMPI +++ ++IGVAQ INK FTE D + + + FCG+ I N Q++ +
Sbjct: 71 KSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASR 130
Query: 376 KLMAKQKVALECLS 389
K + + LE ++
Sbjct: 131 KEYERSRALLEVVN 144
Score = 44.0 bits (99), Expect = 0.002
Identities = 16/42 (38%), Positives = 29/42 (69%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+F++E D +G+ +LC+PI N ++GVAQ++N+ DG+
Sbjct: 246 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 287
Score = 32.3 bits (70), Expect = 7.5
Identities = 12/48 (25%), Positives = 23/48 (47%)
Query: 142 LSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILL 189
L+ K F D +F ++ FCG+GI N +++ + + + L
Sbjct: 281 LNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 328
>AB048423-2|BAB62712.1| 934|Homo sapiens phosphodiesterase 11A4
protein.
Length = 934
Score = 450 bits (1109), Expect = e-125
Identities = 242/580 (41%), Positives = 339/580 (58%), Gaps = 31/580 (5%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+ D +V + YL FCGI I NAQ L A +R +E L +V +
Sbjct: 351 FTEDDEKVMQMYLPFCGIAISNAQ--------------LFAASRKEYERSRALLEVVNDL 396
Query: 210 MTEARDLLKCERC----AVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXX 265
E DL K + A +L + C LE I
Sbjct: 397 FEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDI--ESPVVKFTKSFELMSPKCSADAE 454
Query: 266 TRFHTVFELGAPRRPHDAL--PAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRT 323
F E + D L +IA VA + +NISD Q R + + + +R+
Sbjct: 455 NSFKESMEKSSYS---DWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRS 511
Query: 324 LLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLM 378
+LC+PI N+N +IGVAQ++N+ F + D +FEAF IFCGLGI+NT MY+ K
Sbjct: 512 VLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSW 571
Query: 379 AKQKVALECLSYHATASAEDTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF 438
AKQ VAL+ LSYHAT S + K IP + F DF L + A LRMF
Sbjct: 572 AKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMF 631
Query: 439 LQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSD 498
++ +V+KF I Y+ LCRW+L+V+KNYR V YHNWRHA NV Q MFAML T + +++
Sbjct: 632 MELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTE 691
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTS-TMEHHHFDQCVMILNSESNN 557
+EIL ++V CLCHDLDHRGTNNAFQ K+ S LA LY TS T+EHHHF+ VMIL SE +N
Sbjct: 692 VEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHN 751
Query: 558 IFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMM 617
IF LS ++Y D+M +++ +IL+TDL +YF+++++F ELV GE+DW + +++ M+
Sbjct: 752 IFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSML 811
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
MTACD+ A+ KPWE+ ++A+LV EFF+QGD E+L+L P A+ DR +KDELP++Q+
Sbjct: 812 MTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE 871
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
+ID+IC+PLY+ L + P+ A NR +W++L +K
Sbjct: 872 WIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 911
Score = 60.1 bits (139), Expect = 3e-08
Identities = 34/105 (32%), Positives = 56/105 (53%), Gaps = 6/105 (5%)
Query: 291 VARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK----- 345
V +++NI D Q R N+ ++LLCMPI +++ ++IGVAQ INK
Sbjct: 290 VGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGA 349
Query: 346 -FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLS 389
FTE D + + + FCG+ I N Q++ + K + + LE ++
Sbjct: 350 PFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVN 394
Score = 56.0 bits (129), Expect = 5e-07
Identities = 26/47 (55%), Positives = 35/47 (74%), Gaps = 1/47 (2%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINK-TDGEHTTE 100
+FN EID TGYKT+ +LCMPI + +G+++GVAQ INK +G TE
Sbjct: 307 RFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTE 353
Score = 44.0 bits (99), Expect = 0.002
Identities = 16/42 (38%), Positives = 29/42 (69%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+F++E D +G+ +LC+PI N ++GVAQ++N+ DG+
Sbjct: 496 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 537
Score = 32.3 bits (70), Expect = 7.5
Identities = 12/48 (25%), Positives = 23/48 (47%)
Query: 142 LSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILL 189
L+ K F D +F ++ FCG+GI N +++ + + + L
Sbjct: 531 LNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 578
>AB048423-1|BAB62713.2| 684|Homo sapiens phosphodiesterase 11A3
protein.
Length = 684
Score = 450 bits (1109), Expect = e-125
Identities = 242/580 (41%), Positives = 339/580 (58%), Gaps = 31/580 (5%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+ D +V + YL FCGI I NAQ L A +R +E L +V +
Sbjct: 101 FTEDDEKVMQMYLPFCGIAISNAQ--------------LFAASRKEYERSRALLEVVNDL 146
Query: 210 MTEARDLLKCERC----AVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXX 265
E DL K + A +L + C LE I
Sbjct: 147 FEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDI--ESPVVKFTKSFELMSPKCSADAE 204
Query: 266 TRFHTVFELGAPRRPHDAL--PAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRT 323
F E + D L +IA VA + +NISD Q R + + + +R+
Sbjct: 205 NSFKESMEKSSYS---DWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRS 261
Query: 324 LLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLM 378
+LC+PI N+N +IGVAQ++N+ F + D +FEAF IFCGLGI+NT MY+ K
Sbjct: 262 VLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSW 321
Query: 379 AKQKVALECLSYHATASAEDTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF 438
AKQ VAL+ LSYHAT S + K IP + F DF L + A LRMF
Sbjct: 322 AKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMF 381
Query: 439 LQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSD 498
++ +V+KF I Y+ LCRW+L+V+KNYR V YHNWRHA NV Q MFAML T + +++
Sbjct: 382 MELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTE 441
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTS-TMEHHHFDQCVMILNSESNN 557
+EIL ++V CLCHDLDHRGTNNAFQ K+ S LA LY TS T+EHHHF+ VMIL SE +N
Sbjct: 442 VEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHN 501
Query: 558 IFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMM 617
IF LS ++Y D+M +++ +IL+TDL +YF+++++F ELV GE+DW + +++ M+
Sbjct: 502 IFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSML 561
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
MTACD+ A+ KPWE+ ++A+LV EFF+QGD E+L+L P A+ DR +KDELP++Q+
Sbjct: 562 MTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE 621
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
+ID+IC+PLY+ L + P+ A NR +W++L +K
Sbjct: 622 WIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 661
Score = 56.0 bits (129), Expect = 5e-07
Identities = 26/47 (55%), Positives = 35/47 (74%), Gaps = 1/47 (2%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINK-TDGEHTTE 100
+FN EID TGYKT+ +LCMPI + +G+++GVAQ INK +G TE
Sbjct: 57 RFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTE 103
Score = 55.2 bits (127), Expect = 9e-07
Identities = 27/74 (36%), Positives = 45/74 (60%), Gaps = 6/74 (8%)
Query: 322 RTLLCMPIVNANKDVIGVAQLINK------FTEGDVSIFEAFAIFCGLGIHNTQMYENAC 375
++LLCMPI +++ ++IGVAQ INK FTE D + + + FCG+ I N Q++ +
Sbjct: 71 KSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASR 130
Query: 376 KLMAKQKVALECLS 389
K + + LE ++
Sbjct: 131 KEYERSRALLEVVN 144
Score = 44.0 bits (99), Expect = 0.002
Identities = 16/42 (38%), Positives = 29/42 (69%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+F++E D +G+ +LC+PI N ++GVAQ++N+ DG+
Sbjct: 246 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 287
Score = 32.3 bits (70), Expect = 7.5
Identities = 12/48 (25%), Positives = 23/48 (47%)
Query: 142 LSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILL 189
L+ K F D +F ++ FCG+GI N +++ + + + L
Sbjct: 281 LNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 328
>AB038041-1|BAB16372.1| 684|Homo sapiens phosphodiesterase 11A3
protein.
Length = 684
Score = 450 bits (1109), Expect = e-125
Identities = 242/580 (41%), Positives = 339/580 (58%), Gaps = 31/580 (5%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+ D +V + YL FCGI I NAQ L A +R +E L +V +
Sbjct: 101 FTEDDEKVMQMYLPFCGIAISNAQ--------------LFAASRKEYERSRALLEVVNDL 146
Query: 210 MTEARDLLKCERC----AVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXX 265
E DL K + A +L + C LE I
Sbjct: 147 FEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDI--ESPVVKFTKSFELMSPKCSADAE 204
Query: 266 TRFHTVFELGAPRRPHDAL--PAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRT 323
F E + D L +IA VA + +NISD Q R + + + +R+
Sbjct: 205 NSFKESMEKSSYS---DWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRS 261
Query: 324 LLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLM 378
+LC+PI N+N +IGVAQ++N+ F + D +FEAF IFCGLGI+NT MY+ K
Sbjct: 262 VLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSW 321
Query: 379 AKQKVALECLSYHATASAEDTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF 438
AKQ VAL+ LSYHAT S + K IP + F DF L + A LRMF
Sbjct: 322 AKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMF 381
Query: 439 LQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSD 498
++ +V+KF I Y+ LCRW+L+V+KNYR V YHNWRHA NV Q MFAML T + +++
Sbjct: 382 MELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTE 441
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTS-TMEHHHFDQCVMILNSESNN 557
+EIL ++V CLCHDLDHRGTNNAFQ K+ S LA LY TS T+EHHHF+ VMIL SE +N
Sbjct: 442 VEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHN 501
Query: 558 IFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMM 617
IF LS ++Y D+M +++ +IL+TDL +YF+++++F ELV GE+DW + +++ M+
Sbjct: 502 IFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSML 561
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
MTACD+ A+ KPWE+ ++A+LV EFF+QGD E+L+L P A+ DR +KDELP++Q+
Sbjct: 562 MTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE 621
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
+ID+IC+PLY+ L + P+ A NR +W++L +K
Sbjct: 622 WIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 661
Score = 56.0 bits (129), Expect = 5e-07
Identities = 26/47 (55%), Positives = 35/47 (74%), Gaps = 1/47 (2%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINK-TDGEHTTE 100
+FN EID TGYKT+ +LCMPI + +G+++GVAQ INK +G TE
Sbjct: 57 RFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTE 103
Score = 55.2 bits (127), Expect = 9e-07
Identities = 27/74 (36%), Positives = 45/74 (60%), Gaps = 6/74 (8%)
Query: 322 RTLLCMPIVNANKDVIGVAQLINK------FTEGDVSIFEAFAIFCGLGIHNTQMYENAC 375
++LLCMPI +++ ++IGVAQ INK FTE D + + + FCG+ I N Q++ +
Sbjct: 71 KSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASR 130
Query: 376 KLMAKQKVALECLS 389
K + + LE ++
Sbjct: 131 KEYERSRALLEVVN 144
Score = 44.0 bits (99), Expect = 0.002
Identities = 16/42 (38%), Positives = 29/42 (69%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+F++E D +G+ +LC+PI N ++GVAQ++N+ DG+
Sbjct: 246 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 287
Score = 32.3 bits (70), Expect = 7.5
Identities = 12/48 (25%), Positives = 23/48 (47%)
Query: 142 LSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILL 189
L+ K F D +F ++ FCG+GI N +++ + + + L
Sbjct: 281 LNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 328
>AB036704-1|BAB16371.1| 934|Homo sapiens phosphodiesterase 11A
protein.
Length = 934
Score = 450 bits (1109), Expect = e-125
Identities = 242/580 (41%), Positives = 339/580 (58%), Gaps = 31/580 (5%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+ D +V + YL FCGI I NAQ L A +R +E L +V +
Sbjct: 351 FTEDDEKVMQMYLPFCGIAISNAQ--------------LFAASRKEYERSRALLEVVNDL 396
Query: 210 MTEARDLLKCERC----AVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXX 265
E DL K + A +L + C LE I
Sbjct: 397 FEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDI--ESPVVKFTKSFELMSPKCSADAE 454
Query: 266 TRFHTVFELGAPRRPHDAL--PAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRT 323
F E + D L +IA VA + +NISD Q R + + + +R+
Sbjct: 455 NSFKESMEKSSYS---DWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRS 511
Query: 324 LLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLM 378
+LC+PI N+N +IGVAQ++N+ F + D +FEAF IFCGLGI+NT MY+ K
Sbjct: 512 VLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSW 571
Query: 379 AKQKVALECLSYHATASAEDTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF 438
AKQ VAL+ LSYHAT S + K IP + F DF L + A LRMF
Sbjct: 572 AKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMF 631
Query: 439 LQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSD 498
++ +V+KF I Y+ LCRW+L+V+KNYR V YHNWRHA NV Q MFAML T + +++
Sbjct: 632 MELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTE 691
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTS-TMEHHHFDQCVMILNSESNN 557
+EIL ++V CLCHDLDHRGTNNAFQ K+ S LA LY TS T+EHHHF+ VMIL SE +N
Sbjct: 692 VEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHN 751
Query: 558 IFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMM 617
IF LS ++Y D+M +++ +IL+TDL +YF+++++F ELV GE+DW + +++ M+
Sbjct: 752 IFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSML 811
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
MTACD+ A+ KPWE+ ++A+LV EFF+QGD E+L+L P A+ DR +KDELP++Q+
Sbjct: 812 MTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLE 871
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
+ID+IC+PLY+ L + P+ A NR +W++L +K
Sbjct: 872 WIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 911
Score = 60.1 bits (139), Expect = 3e-08
Identities = 34/105 (32%), Positives = 56/105 (53%), Gaps = 6/105 (5%)
Query: 291 VARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK----- 345
V +++NI D Q R N+ ++LLCMPI +++ ++IGVAQ INK
Sbjct: 290 VGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGA 349
Query: 346 -FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLS 389
FTE D + + + FCG+ I N Q++ + K + + LE ++
Sbjct: 350 PFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVN 394
Score = 56.0 bits (129), Expect = 5e-07
Identities = 26/47 (55%), Positives = 35/47 (74%), Gaps = 1/47 (2%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINK-TDGEHTTE 100
+FN EID TGYKT+ +LCMPI + +G+++GVAQ INK +G TE
Sbjct: 307 RFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTE 353
Score = 44.0 bits (99), Expect = 0.002
Identities = 16/42 (38%), Positives = 29/42 (69%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+F++E D +G+ +LC+PI N ++GVAQ++N+ DG+
Sbjct: 496 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 537
Score = 32.3 bits (70), Expect = 7.5
Identities = 12/48 (25%), Positives = 23/48 (47%)
Query: 142 LSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILL 189
L+ K F D +F ++ FCG+GI N +++ + + + L
Sbjct: 531 LNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 578
>AJ251509-1|CAB82573.1| 490|Homo sapiens cyclic nucleotide
phosphodiesterase 11A1 protein.
Length = 490
Score = 447 bits (1102), Expect = e-125
Identities = 209/438 (47%), Positives = 295/438 (67%), Gaps = 6/438 (1%)
Query: 286 AIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK 345
+IA VA + +NISD Q R + + + +R++LC+PI N+N +IGVAQ++N+
Sbjct: 30 SIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNR 89
Query: 346 -----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTS 400
F + D +FEAF IFCGLGI+NT MY+ K AKQ VAL+ LSYHAT S +
Sbjct: 90 LDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVD 149
Query: 401 KLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILS 460
K IP + F DF L + A LRMF++ +V+KF I Y+ LCRW+L+
Sbjct: 150 KFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLT 209
Query: 461 VKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNN 520
V+KNYR V YHNWRHA NV Q MFAML T + ++++EIL ++V CLCHDLDHRGTNN
Sbjct: 210 VRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNN 269
Query: 521 AFQTKTESPLAILYSTS-TMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAIL 579
AFQ K+ S LA LY TS T+EHHHF+ VMIL SE +NIF LS ++Y D+M +++ +IL
Sbjct: 270 AFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSIL 329
Query: 580 STDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKL 639
+TDL +YF+++++F ELV GE+DW + +++ M+MTACD+ A+ KPWE+ ++A+L
Sbjct: 330 ATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAEL 389
Query: 640 VADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTP 699
V EFF+QGD E+L+L P A+ DR +KDELP++Q+ +ID+IC+PLY+ L + P
Sbjct: 390 VTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP 449
Query: 700 LRTGTADNRRRWQDLAEK 717
+ A NR +W++L +K
Sbjct: 450 MLDSVATNRSKWEELHQK 467
Score = 44.0 bits (99), Expect = 0.002
Identities = 16/42 (38%), Positives = 29/42 (69%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+F++E D +G+ +LC+PI N ++GVAQ++N+ DG+
Sbjct: 52 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 93
Score = 32.3 bits (70), Expect = 7.5
Identities = 12/48 (25%), Positives = 23/48 (47%)
Query: 142 LSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILL 189
L+ K F D +F ++ FCG+GI N +++ + + + L
Sbjct: 87 LNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 134
>AF281865-1|AAG32023.1| 576|Homo sapiens cAMP/cGMP
phosphodiesterase 11A2 protein.
Length = 576
Score = 447 bits (1102), Expect = e-125
Identities = 209/438 (47%), Positives = 295/438 (67%), Gaps = 6/438 (1%)
Query: 286 AIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK 345
+IA VA + +NISD Q R + + + +R++LC+PI N+N +IGVAQ++N+
Sbjct: 116 SIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNR 175
Query: 346 -----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTS 400
F + D +FEAF IFCGLGI+NT MY+ K AKQ VAL+ LSYHAT S +
Sbjct: 176 LDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVD 235
Query: 401 KLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILS 460
K IP + F DF L + A LRMF++ +V+KF I Y+ LCRW+L+
Sbjct: 236 KFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLT 295
Query: 461 VKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNN 520
V+KNYR V YHNWRHA NV Q MFAML T + ++++EIL ++V CLCHDLDHRGTNN
Sbjct: 296 VRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNN 355
Query: 521 AFQTKTESPLAILYSTS-TMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAIL 579
AFQ K+ S LA LY TS T+EHHHF+ VMIL SE +NIF LS ++Y D+M +++ +IL
Sbjct: 356 AFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSIL 415
Query: 580 STDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKL 639
+TDL +YF+++++F ELV GE+DW + +++ M+MTACD+ A+ KPWE+ ++A+L
Sbjct: 416 ATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAEL 475
Query: 640 VADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTP 699
V EFF+QGD E+L+L P A+ DR +KDELP++Q+ +ID+IC+PLY+ L + P
Sbjct: 476 VTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP 535
Query: 700 LRTGTADNRRRWQDLAEK 717
+ A NR +W++L +K
Sbjct: 536 MLDSVATNRSKWEELHQK 553
Score = 83.0 bits (196), Expect = 4e-15
Identities = 38/68 (55%), Positives = 51/68 (75%)
Query: 161 YLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKIMTEARDLLKCE 220
YL FCGI I NAQLF +S EY+R++ LL + +FEEQ++LE +V KIM A+ LLKCE
Sbjct: 4 YLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCE 63
Query: 221 RCAVFILD 228
RC+V +L+
Sbjct: 64 RCSVLLLE 71
Score = 44.0 bits (99), Expect = 0.002
Identities = 16/42 (38%), Positives = 29/42 (69%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+F++E D +G+ +LC+PI N ++GVAQ++N+ DG+
Sbjct: 138 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 179
Score = 32.3 bits (70), Expect = 7.5
Identities = 12/48 (25%), Positives = 23/48 (47%)
Query: 142 LSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILL 189
L+ K F D +F ++ FCG+GI N +++ + + + L
Sbjct: 173 LNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 220
>AB048423-3|BAB62714.1| 490|Homo sapiens phosphodiesterase 11A1
protein.
Length = 490
Score = 447 bits (1102), Expect = e-125
Identities = 209/438 (47%), Positives = 295/438 (67%), Gaps = 6/438 (1%)
Query: 286 AIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK 345
+IA VA + +NISD Q R + + + +R++LC+PI N+N +IGVAQ++N+
Sbjct: 30 SIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNR 89
Query: 346 -----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTS 400
F + D +FEAF IFCGLGI+NT MY+ K AKQ VAL+ LSYHAT S +
Sbjct: 90 LDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVD 149
Query: 401 KLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILS 460
K IP + F DF L + A LRMF++ +V+KF I Y+ LCRW+L+
Sbjct: 150 KFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLT 209
Query: 461 VKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNN 520
V+KNYR V YHNWRHA NV Q MFAML T + ++++EIL ++V CLCHDLDHRGTNN
Sbjct: 210 VRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNN 269
Query: 521 AFQTKTESPLAILYSTS-TMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAIL 579
AFQ K+ S LA LY TS T+EHHHF+ VMIL SE +NIF LS ++Y D+M +++ +IL
Sbjct: 270 AFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSIL 329
Query: 580 STDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKL 639
+TDL +YF+++++F ELV GE+DW + +++ M+MTACD+ A+ KPWE+ ++A+L
Sbjct: 330 ATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAEL 389
Query: 640 VADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTP 699
V EFF+QGD E+L+L P A+ DR +KDELP++Q+ +ID+IC+PLY+ L + P
Sbjct: 390 VTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKP 449
Query: 700 LRTGTADNRRRWQDLAEK 717
+ A NR +W++L +K
Sbjct: 450 MLDSVATNRSKWEELHQK 467
Score = 44.0 bits (99), Expect = 0.002
Identities = 16/42 (38%), Positives = 29/42 (69%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+F++E D +G+ +LC+PI N ++GVAQ++N+ DG+
Sbjct: 52 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 93
Score = 32.3 bits (70), Expect = 7.5
Identities = 12/48 (25%), Positives = 23/48 (47%)
Query: 142 LSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILL 189
L+ K F D +F ++ FCG+GI N +++ + + + L
Sbjct: 87 LNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 134
>AL356214-7|CAH72330.1| 858|Homo sapiens phosphodiesterase 6C,
cGMP-specific, cone, alpha prime protein.
Length = 858
Score = 392 bits (965), Expect = e-108
Identities = 224/629 (35%), Positives = 342/629 (54%), Gaps = 48/629 (7%)
Query: 147 SKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLV 206
+ EFS +D EVF +YL F I ++ +E +R+QIL+ A +FEE +++E
Sbjct: 202 ASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQF 261
Query: 207 TKIMTEARDLLKCERCAVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXXT 266
K + R L CER ++ +LD + + E ++
Sbjct: 262 HKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKII 321
Query: 267 RF--HTVFELGA-PRRPHD---ALPAIALAVARSNKSLNISDV--EQWLRDNNMSAGENS 318
+ H E+ P P D + + VA + N+ + +++ E
Sbjct: 322 DYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETG 381
Query: 319 AGVRTLLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYEN 373
++ +L +PIVN +D++GVA N+ F E D I E F G + NT Y+
Sbjct: 382 WVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDK 441
Query: 374 ACKLMAKQKVALECLSYHATASAEDTSKL--------------CQD---------EIPSA 410
KL ++ +A E L A+ E+ + C++ ++P
Sbjct: 442 MNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDP 501
Query: 411 ETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKY 470
+ LY F+F DF LT+ + +R+F + +VEKF +P +VL RW+ +V+K YR V Y
Sbjct: 502 RSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTY 561
Query: 471 HNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPL 530
HNWRH NV QTMF +L TG+++++ +DLE +L A CHD+DHRGTNN +Q K+ SPL
Sbjct: 562 HNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPL 621
Query: 531 AILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKK 590
A L+ +S +E HH + +L ES NIFQ L+ R ++ V+H+ E AI++TDLA+YFKK+
Sbjct: 622 ARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKR 681
Query: 591 SKFLELVDNGEFDWQAQE-----------KKELLCGMMMTACDVSAIAKPWEVQHRIAKL 639
+ F ++VD E Q +E KKE++ MMMTACD+SAI KPWEVQ ++A +
Sbjct: 682 TMFQKIVDACE-QMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALM 740
Query: 640 VADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTP 699
VA+EF++QGDLE+ L QQPI MMDR K+DELP++QVGFID +C +YK S +TP
Sbjct: 741 VANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITP 800
Query: 700 LRTGTADNRRRWQDLAEKVDMGLTWIDHD 728
+ +G +NR W+ LA++ D + I+ +
Sbjct: 801 MLSGLQNNRVEWKSLADEYDAKMKVIEEE 829
Score = 35.9 bits (79), Expect = 0.61
Identities = 19/49 (38%), Positives = 29/49 (59%), Gaps = 2/49 (4%)
Query: 48 AIKYITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
A +Y T Q +D TG+ + +L +PI N + D+VGVA N+ DG+
Sbjct: 366 ADEYFTFQ-KGPVD-ETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGK 412
>AL157396-4|CAH73839.1| 858|Homo sapiens phosphodiesterase 6C,
cGMP-specific, cone, alpha prime protein.
Length = 858
Score = 392 bits (965), Expect = e-108
Identities = 224/629 (35%), Positives = 342/629 (54%), Gaps = 48/629 (7%)
Query: 147 SKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLV 206
+ EFS +D EVF +YL F I ++ +E +R+QIL+ A +FEE +++E
Sbjct: 202 ASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQF 261
Query: 207 TKIMTEARDLLKCERCAVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXXT 266
K + R L CER ++ +LD + + E ++
Sbjct: 262 HKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKII 321
Query: 267 RF--HTVFELGA-PRRPHD---ALPAIALAVARSNKSLNISDV--EQWLRDNNMSAGENS 318
+ H E+ P P D + + VA + N+ + +++ E
Sbjct: 322 DYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETG 381
Query: 319 AGVRTLLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYEN 373
++ +L +PIVN +D++GVA N+ F E D I E F G + NT Y+
Sbjct: 382 WVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDK 441
Query: 374 ACKLMAKQKVALECLSYHATASAEDTSKL--------------CQD---------EIPSA 410
KL ++ +A E L A+ E+ + C++ ++P
Sbjct: 442 MNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDP 501
Query: 411 ETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKY 470
+ LY F+F DF LT+ + +R+F + +VEKF +P +VL RW+ +V+K YR V Y
Sbjct: 502 RSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTY 561
Query: 471 HNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPL 530
HNWRH NV QTMF +L TG+++++ +DLE +L A CHD+DHRGTNN +Q K+ SPL
Sbjct: 562 HNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPL 621
Query: 531 AILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKK 590
A L+ +S +E HH + +L ES NIFQ L+ R ++ V+H+ E AI++TDLA+YFKK+
Sbjct: 622 ARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKR 681
Query: 591 SKFLELVDNGEFDWQAQE-----------KKELLCGMMMTACDVSAIAKPWEVQHRIAKL 639
+ F ++VD E Q +E KKE++ MMMTACD+SAI KPWEVQ ++A +
Sbjct: 682 TMFQKIVDACE-QMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALM 740
Query: 640 VADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTP 699
VA+EF++QGDLE+ L QQPI MMDR K+DELP++QVGFID +C +YK S +TP
Sbjct: 741 VANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITP 800
Query: 700 LRTGTADNRRRWQDLAEKVDMGLTWIDHD 728
+ +G +NR W+ LA++ D + I+ +
Sbjct: 801 MLSGLQNNRVEWKSLADEYDAKMKVIEEE 829
Score = 35.9 bits (79), Expect = 0.61
Identities = 19/49 (38%), Positives = 29/49 (59%), Gaps = 2/49 (4%)
Query: 48 AIKYITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
A +Y T Q +D TG+ + +L +PI N + D+VGVA N+ DG+
Sbjct: 366 ADEYFTFQ-KGPVD-ETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGK 412
>X94354-1|CAA64079.1| 858|Homo sapiens cone cGMP phosphodiesterase
protein.
Length = 858
Score = 392 bits (964), Expect = e-108
Identities = 224/629 (35%), Positives = 342/629 (54%), Gaps = 48/629 (7%)
Query: 147 SKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLV 206
+ EFS +D EVF +YL F I ++ +E +R+QIL+ A +FEE +++E
Sbjct: 202 ASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQF 261
Query: 207 TKIMTEARDLLKCERCAVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXXT 266
K + R L CER ++ +LD + + E ++
Sbjct: 262 HKALYTVRTYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKII 321
Query: 267 RF--HTVFELGA-PRRPHD---ALPAIALAVARSNKSLNISDV--EQWLRDNNMSAGENS 318
+ H E+ P P D + + VA + N+ + +++ E
Sbjct: 322 DYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETG 381
Query: 319 AGVRTLLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYEN 373
++ +L +PIVN +D++GVA N+ F E D I E F G + NT Y+
Sbjct: 382 WVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDK 441
Query: 374 ACKLMAKQKVALECLSYHATASAEDTSKL--------------CQD---------EIPSA 410
KL ++ +A E L A+ E+ + C++ ++P
Sbjct: 442 MNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDP 501
Query: 411 ETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKY 470
+ LY F+F DF LT+ + +R+F + +VEKF +P +VL RW+ +V+K YR V Y
Sbjct: 502 RSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTY 561
Query: 471 HNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPL 530
HNWRH NV QTMF +L TG+++++ +DLE +L A CHD+DHRGTNN +Q K+ SPL
Sbjct: 562 HNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPL 621
Query: 531 AILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKK 590
A L+ +S +E HH + +L ES NIFQ L+ R ++ V+H+ E AI++TDLA+YFKK+
Sbjct: 622 ARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKR 681
Query: 591 SKFLELVDNGEFDWQAQE-----------KKELLCGMMMTACDVSAIAKPWEVQHRIAKL 639
+ F ++VD E Q +E KKE++ MMMTACD+SAI KPWEVQ ++A +
Sbjct: 682 TMFQKIVDACE-QMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALM 740
Query: 640 VADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTP 699
VA+EF++QGDLE+ L QQPI MMDR K+DELP++QVGFID +C +YK S +TP
Sbjct: 741 VANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITP 800
Query: 700 LRTGTADNRRRWQDLAEKVDMGLTWIDHD 728
+ +G +NR W+ LA++ D + I+ +
Sbjct: 801 MLSGLQNNRVEWKSLADEYDAKMKVIEEE 829
Score = 35.9 bits (79), Expect = 0.61
Identities = 19/49 (38%), Positives = 29/49 (59%), Gaps = 2/49 (4%)
Query: 48 AIKYITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
A +Y T Q +D TG+ + +L +PI N + D+VGVA N+ DG+
Sbjct: 366 ADEYFTFQ-KGPVD-ETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGK 412
>U20212-1|AAA92886.1| 858|Homo sapiens cone photoreceptor
cGMP-phosphodiesterase alpha' subunit protein.
Length = 858
Score = 390 bits (961), Expect = e-108
Identities = 223/629 (35%), Positives = 342/629 (54%), Gaps = 48/629 (7%)
Query: 147 SKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLV 206
+ EFS +D EVF +YL F I ++ +E +R+QIL+ A +FEE +++E
Sbjct: 202 ASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQF 261
Query: 207 TKIMTEARDLLKCERCAVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXXT 266
K + R L CER ++ +LD + + E ++
Sbjct: 262 HKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKII 321
Query: 267 RF--HTVFELGA-PRRPHD---ALPAIALAVARSNKSLNISDV--EQWLRDNNMSAGENS 318
+ H E+ P P D + + VA + N+ + +++ E
Sbjct: 322 DYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETG 381
Query: 319 AGVRTLLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYEN 373
++ +L +PIVN +D++GVA N+ F E D I E F G + NT Y+
Sbjct: 382 WVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDK 441
Query: 374 ACKLMAKQKVALECLSYHATASAEDTSKL--------------CQD---------EIPSA 410
KL ++ +A E L A+ E+ + C++ ++P
Sbjct: 442 MNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDP 501
Query: 411 ETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKY 470
+ LY F+F DF LT+ + +R+F + +VEKF +P +VL RW+ +V+K YR V Y
Sbjct: 502 RSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTY 561
Query: 471 HNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPL 530
HNW+H NV QTMF +L TG+++++ +DLE +L A CHD+DHRGTNN +Q K+ SPL
Sbjct: 562 HNWQHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPL 621
Query: 531 AILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKK 590
A L+ +S +E HH + +L ES NIFQ L+ R ++ V+H+ E AI++TDLA+YFKK+
Sbjct: 622 ARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKR 681
Query: 591 SKFLELVDNGEFDWQAQE-----------KKELLCGMMMTACDVSAIAKPWEVQHRIAKL 639
+ F ++VD E Q +E KKE++ MMMTACD+SAI KPWEVQ ++A +
Sbjct: 682 TMFQKIVDACE-QMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALM 740
Query: 640 VADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTP 699
VA+EF++QGDLE+ L QQPI MMDR K+DELP++QVGFID +C +YK S +TP
Sbjct: 741 VANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITP 800
Query: 700 LRTGTADNRRRWQDLAEKVDMGLTWIDHD 728
+ +G +NR W+ LA++ D + I+ +
Sbjct: 801 MLSGLQNNRVEWKSLADEYDAKMKVIEEE 829
Score = 35.9 bits (79), Expect = 0.61
Identities = 19/49 (38%), Positives = 29/49 (59%), Gaps = 2/49 (4%)
Query: 48 AIKYITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
A +Y T Q +D TG+ + +L +PI N + D+VGVA N+ DG+
Sbjct: 366 ADEYFTFQ-KGPVD-ETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGK 412
>U31973-1|AAA96392.1| 858|Homo sapiens phosphodiesterase A' subunit
protein.
Length = 858
Score = 390 bits (959), Expect = e-107
Identities = 223/629 (35%), Positives = 342/629 (54%), Gaps = 48/629 (7%)
Query: 147 SKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLV 206
+ EFS +D EVF +YL F I ++ +E +R+QIL+ A +FEE +++E
Sbjct: 202 ASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQF 261
Query: 207 TKIMTEARDLLKCERCAVFILDTDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXXT 266
K + R L CER ++ +LD + + E ++
Sbjct: 262 HKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKII 321
Query: 267 RF--HTVFELGA-PRRPHD---ALPAIALAVARSNKSLNISDV--EQWLRDNNMSAGENS 318
+ H E+ P P D + + VA + N+ + +++ E
Sbjct: 322 DYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFPKGPVDETG 381
Query: 319 AGVRTLLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYEN 373
++ +L +PIVN +D++GVA N+ F E D I E F G + NT Y+
Sbjct: 382 WVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDK 441
Query: 374 ACKLMAKQKVALECLSYHATASAEDTSKL--------------CQD---------EIPSA 410
KL ++ +A E L A+ E+ + C++ ++P
Sbjct: 442 MNKLENRKDIAQEMLMNQTKATLEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDP 501
Query: 411 ETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKY 470
+ LY F+F DF LT+ + +R+F + +VEKF +P +VL RW+ +V+K YR V Y
Sbjct: 502 RSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTY 561
Query: 471 HNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPL 530
HNW+H NV QTMF +L TG+++++ +DLE +L A CHD+DHRGTNN +Q K+ SPL
Sbjct: 562 HNWQHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPL 621
Query: 531 AILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKK 590
A L+ +S +E HH + +L ES NIFQ L+ R ++ V+H+ E AI++TDLA+YFKK+
Sbjct: 622 ARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKR 681
Query: 591 SKFLELVDNGEFDWQAQE-----------KKELLCGMMMTACDVSAIAKPWEVQHRIAKL 639
+ F ++VD E Q +E KKE++ MMMTACD+SAI KPWEVQ ++A +
Sbjct: 682 TMFQKIVDACE-QMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALM 740
Query: 640 VADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTP 699
VA+EF++QGDLE+ L QQPI MMDR K+DELP++QVGFID +C +YK S +TP
Sbjct: 741 VANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITP 800
Query: 700 LRTGTADNRRRWQDLAEKVDMGLTWIDHD 728
+ +G +NR W+ LA++ D + I+ +
Sbjct: 801 MLSGLQNNRVEWKSLADEYDAKMKVIEEE 829
Score = 33.9 bits (74), Expect = 2.4
Identities = 14/33 (42%), Positives = 22/33 (66%)
Query: 64 TGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
TG+ + +L +PI N + D+VGVA N+ DG+
Sbjct: 380 TGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGK 412
>BC035909-1|AAH35909.1| 860|Homo sapiens phosphodiesterase 6A,
cGMP-specific, rod, alpha protein.
Length = 860
Score = 378 bits (930), Expect = e-104
Identities = 215/615 (34%), Positives = 335/615 (54%), Gaps = 45/615 (7%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+ RD E+ +YL F + ++ L E +R QILL +FEE +++E K
Sbjct: 203 FTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKA 262
Query: 210 MTEARDLLKCERCAVFILD-TDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXXTRF 268
+ R L C+R +V +LD T E + ++
Sbjct: 263 LYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYI 322
Query: 269 -HTVFELGA-PRRPHD---ALPAIALAVARSNKSLNISDV--EQWLRDNNMSAGENSAGV 321
H ++ P P D + + VA++ NI + E + E+ +
Sbjct: 323 LHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMI 382
Query: 322 RTLLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACK 376
+ +L MPIVN ++++GVA N+ F E D ++ E+ F G + N YE+ K
Sbjct: 383 KNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNK 442
Query: 377 LMAKQKVALECLSYHATASAEDTSKL-------------CQD---------EIPSAETYN 414
L ++ + + + YH E+ K+ C++ E+P A+ Y
Sbjct: 443 LENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYE 502
Query: 415 LYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWR 474
+ F F D LT+ + + ++M+ + ++V+KFHIP + L R++ S+ K YR + YHNWR
Sbjct: 503 INKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWR 562
Query: 475 HALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY 534
H NV QTMF++L TGK++R+ +DLE L ++ A CHD+DHRGTNN +Q K+++PLA L+
Sbjct: 563 HGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLH 622
Query: 535 STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFL 594
+S +E HH + +L ES NIFQ L+ R ++ +H+++ AI++TDLA+YFKK++ F
Sbjct: 623 GSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQ 682
Query: 595 ELVD-----NGEFDWQ-----AQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEF 644
++VD E +W Q +KE++ MMMTACD+SAI KPWEVQ ++A LVA EF
Sbjct: 683 KIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEF 742
Query: 645 FDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGT 704
++QGDLE+ L Q PI MMDR K DELP++QVGFID +C +YK S +TP+ G
Sbjct: 743 WEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGI 802
Query: 705 ADNRRRWQDLAEKVD 719
+NR+ W+ LA++ D
Sbjct: 803 TNNRKEWKALADEYD 817
Score = 39.1 bits (87), Expect = 0.065
Identities = 19/41 (46%), Positives = 25/41 (60%), Gaps = 1/41 (2%)
Query: 60 IDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTE 100
+D T YKT+ IL PI N + DVV + +NK DG H T+
Sbjct: 166 VDILTEYKTKNILASPIMNGK-DVVAIIMAVNKVDGSHFTK 205
Score = 33.1 bits (72), Expect = 4.3
Identities = 15/41 (36%), Positives = 24/41 (58%)
Query: 56 FNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
F E +G+ + +L MPI N + ++VGVA N+ DG+
Sbjct: 370 FQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGK 410
>M26061-1|AAB69155.1| 860|Homo sapiens PDEA protein.
Length = 860
Score = 378 bits (929), Expect = e-104
Identities = 215/615 (34%), Positives = 335/615 (54%), Gaps = 45/615 (7%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+ RD E+ +YL F + ++ L E +R QILL +FEE +++E K
Sbjct: 203 FTKRDEEILLKYLNFANLIMKWYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKA 262
Query: 210 MTEARDLLKCERCAVFILD-TDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXXTRF 268
+ R L C+R +V +LD T E + ++
Sbjct: 263 LYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYI 322
Query: 269 -HTVFELGA-PRRPHD---ALPAIALAVARSNKSLNISDV--EQWLRDNNMSAGENSAGV 321
H ++ P P D + + VA++ NI + E + E+ +
Sbjct: 323 LHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMI 382
Query: 322 RTLLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACK 376
+ +L MPIVN ++++GVA N+ F E D ++ E+ F G + N YE+ K
Sbjct: 383 KNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNK 442
Query: 377 LMAKQKVALECLSYHATASAEDTSKL-------------CQD---------EIPSAETYN 414
L ++ + + + YH E+ K+ C++ E+P A+ Y
Sbjct: 443 LENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYE 502
Query: 415 LYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWR 474
+ F F D LT+ + + ++M+ + ++V+KFHIP + L R++ S+ K YR + YHNWR
Sbjct: 503 INKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWR 562
Query: 475 HALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY 534
H NV QTMF++L TGK++R+ +DLE L ++ A CHD+DHRGTNN +Q K+++PLA L+
Sbjct: 563 HGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLH 622
Query: 535 STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFL 594
+S +E HH + +L ES NIFQ L+ R ++ +H+++ AI++TDLA+YFKK++ F
Sbjct: 623 GSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQ 682
Query: 595 ELVD-----NGEFDWQ-----AQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEF 644
++VD E +W Q +KE++ MMMTACD+SAI KPWEVQ ++A LVA EF
Sbjct: 683 KIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEF 742
Query: 645 FDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGT 704
++QGDLE+ L Q PI MMDR K DELP++QVGFID +C +YK S +TP+ G
Sbjct: 743 WEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGI 802
Query: 705 ADNRRRWQDLAEKVD 719
+NR+ W+ LA++ D
Sbjct: 803 TNNRKEWKALADEYD 817
Score = 41.9 bits (94), Expect = 0.009
Identities = 34/98 (34%), Positives = 45/98 (45%), Gaps = 8/98 (8%)
Query: 60 IDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLDHNYEPRPGQITRGPV 119
+D T YKT+ IL PI N + DVV + +NK DG H T+ + E + +
Sbjct: 166 VDILTEYKTKNILASPIMNGK-DVVAIIMAVNKVDGSHFTK----RDEEILLKYLNFANL 220
Query: 120 ASHWYSLYYFGNQRLYTYLRRKLSHSGSKEFSS-RDVE 156
WY L Y N T + L SGSK F D+E
Sbjct: 221 IMKWYHLSYLHN--CETRRGQILLWSGSKVFEELTDIE 256
Score = 33.1 bits (72), Expect = 4.3
Identities = 15/41 (36%), Positives = 24/41 (58%)
Query: 56 FNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
F E +G+ + +L MPI N + ++VGVA N+ DG+
Sbjct: 370 FQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGK 410
>AC093752-1|AAY40985.1| 331|Homo sapiens unknown protein.
Length = 331
Score = 372 bits (914), Expect = e-102
Identities = 170/312 (54%), Positives = 223/312 (71%), Gaps = 1/312 (0%)
Query: 407 IPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYR 466
+PSA+T + F F DF+L+D +T T+RMF LV+ F + ++VLCRWILSVKKNYR
Sbjct: 4 VPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYR 63
Query: 467 P-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTK 525
V YHNWRHA N AQ MFA LK GK++ ++DLEIL LL+A L HDLDHRG NN++ +
Sbjct: 64 KNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQR 123
Query: 526 TESPLAILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAM 585
+E PLA LY S MEHHHFDQC+MILNS N I LS +YK + +++ AIL+TDLA+
Sbjct: 124 SEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLAL 183
Query: 586 YFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFF 645
Y K++ +F EL+ +F+ + +KEL M+MTACD+SAI KPW +Q RIA+LVA EFF
Sbjct: 184 YIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFF 243
Query: 646 DQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTA 705
DQGD E+ +LN +P +M+REKK+++P MQVGFID ICL LY+ L+ PL G
Sbjct: 244 DQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCR 303
Query: 706 DNRRRWQDLAEK 717
NR++WQ LAE+
Sbjct: 304 KNRQKWQALAEQ 315
>X66142-1|CAA46932.1| 854|Homo sapiens 3',5'-cyclic-nucleotide
phosphodiesterase protein.
Length = 854
Score = 368 bits (905), Expect = e-101
Identities = 209/615 (33%), Positives = 337/615 (54%), Gaps = 45/615 (7%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+S D +VF +YL F + ++ L E +R Q+LL A +FEE +++E K
Sbjct: 201 FTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKA 260
Query: 210 MTEARDLLKCERCAVFILD-TDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXXTRF 268
R L CER +V +LD T E + ++
Sbjct: 261 FYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYI 320
Query: 269 ----HTVFELGAPRRPHDALPA-IALAVARSNKSLNI--SDVEQWLRDNNMSAGENSAGV 321
+ + P H AL + + VA S NI + ++ + + ++ +
Sbjct: 321 LHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLI 380
Query: 322 RTLLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACK 376
+ +L MPIVN ++++GVA N+ F E D + E+ F G + NT Y+ K
Sbjct: 381 KNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNK 440
Query: 377 LMAKQKVALECLSYH----------------------ATASAEDTSKLCQDEIPSAETYN 414
L ++ +A + + YH A ++ ++ ++E+P T++
Sbjct: 441 LENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFD 500
Query: 415 LYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWR 474
+Y F F D + T+ D + ++M+ + +V KF IP +VL R++ S+ K YR + YHNWR
Sbjct: 501 IYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWR 560
Query: 475 HALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY 534
H NVAQTMF +L TGK++ + +DLE ++ A LCHD+DHRGTNN +Q K+++PLA L+
Sbjct: 561 HGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLH 620
Query: 535 STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFL 594
+S +E HH + +L+ E+ NI+Q L+ R ++ V+H+++ AI++TDLA+YFKK++ F
Sbjct: 621 GSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQ 680
Query: 595 ELVDNGE--------FDWQAQE--KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEF 644
++VD + ++ + E +KE++ MMMTACD+SAI KPWEVQ ++A LVA EF
Sbjct: 681 KIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEF 740
Query: 645 FDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGT 704
++QGDLE+ L+QQPI MMDR K ELP++QVGFID +C +YK S + P+
Sbjct: 741 WEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRL 800
Query: 705 ADNRRRWQDLAEKVD 719
+NR+ W+ LA++ +
Sbjct: 801 QNNRKEWKALADEYE 815
Score = 34.3 bits (75), Expect = 1.9
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Query: 56 FNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLD 104
F+S D T YKT+ +L PI N + DVV V +NK +G T D
Sbjct: 160 FSSFADELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDED 207
Score = 31.9 bits (69), Expect = 9.9
Identities = 13/33 (39%), Positives = 22/33 (66%)
Query: 64 TGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+G+ + +L MPI N + ++VGVA N+ DG+
Sbjct: 376 SGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGK 408
>S41458-1|AAB22690.1| 854|Homo sapiens rod cGMP phosphodiesterase
beta-subunit protein.
Length = 854
Score = 368 bits (905), Expect = e-101
Identities = 209/615 (33%), Positives = 337/615 (54%), Gaps = 45/615 (7%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+S D +VF +YL F + ++ L E +R Q+LL A +FEE +++E K
Sbjct: 201 FTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKA 260
Query: 210 MTEARDLLKCERCAVFILD-TDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXXTRF 268
R L CER +V +LD T E + ++
Sbjct: 261 FYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYI 320
Query: 269 ----HTVFELGAPRRPHDALPA-IALAVARSNKSLNI--SDVEQWLRDNNMSAGENSAGV 321
+ + P H AL + + VA S NI + ++ + + ++ +
Sbjct: 321 LHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLI 380
Query: 322 RTLLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACK 376
+ +L MPIVN ++++GVA N+ F E D + E+ F G + NT Y+ K
Sbjct: 381 KNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNK 440
Query: 377 LMAKQKVALECLSYH----------------------ATASAEDTSKLCQDEIPSAETYN 414
L ++ +A + + YH A ++ ++ ++E+P T++
Sbjct: 441 LENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFD 500
Query: 415 LYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWR 474
+Y F F D + T+ D + ++M+ + +V KF IP +VL R++ S+ K YR + YHNWR
Sbjct: 501 IYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWR 560
Query: 475 HALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY 534
H NVAQTMF +L TGK++ + +DLE ++ A LCHD+DHRGTNN +Q K+++PLA L+
Sbjct: 561 HGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLH 620
Query: 535 STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFL 594
+S +E HH + +L+ E+ NI+Q L+ R ++ V+H+++ AI++TDLA+YFKK++ F
Sbjct: 621 GSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQ 680
Query: 595 ELVDNGE--------FDWQAQE--KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEF 644
++VD + ++ + E +KE++ MMMTACD+SAI KPWEVQ ++A LVA EF
Sbjct: 681 KIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEF 740
Query: 645 FDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGT 704
++QGDLE+ L+QQPI MMDR K ELP++QVGFID +C +YK S + P+
Sbjct: 741 WEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRL 800
Query: 705 ADNRRRWQDLAEKVD 719
+NR+ W+ LA++ +
Sbjct: 801 QNNRKEWKALADEYE 815
Score = 34.3 bits (75), Expect = 1.9
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Query: 56 FNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLD 104
F+S D T YKT+ +L PI N + DVV V +NK +G T D
Sbjct: 160 FSSFADELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDED 207
Score = 31.9 bits (69), Expect = 9.9
Identities = 13/33 (39%), Positives = 22/33 (66%)
Query: 64 TGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+G+ + +L MPI N + ++VGVA N+ DG+
Sbjct: 376 SGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGK 408
>X62692-1|CAA44569.1| 854|Homo sapiens cGMP phosphodiesterase beta
subunit protein.
Length = 854
Score = 367 bits (903), Expect = e-101
Identities = 209/616 (33%), Positives = 338/616 (54%), Gaps = 47/616 (7%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+S D +VF +YL F + ++ L E +R Q+LL A +FEE +++E K
Sbjct: 201 FTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKA 260
Query: 210 MTEARDLLKCERCAVFILD-TDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXXTRF 268
R L CER +V +LD T E + ++
Sbjct: 261 FYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYQVIDYL 320
Query: 269 ----HTVFELGAPRRPHDALPA-IALAVARSNKSLNISD--VEQWLRDNNMSAGENSAGV 321
+ + P H AL + + VA S NI + ++ + + ++ +
Sbjct: 321 LHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNRSADEMFKFQEGALDDSGWLI 380
Query: 322 RTLLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACK 376
+ +L MPIVN ++++GVA N+ F E D + E+ F G + NT Y+ K
Sbjct: 381 KNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNK 440
Query: 377 LMAKQKVALECLSYH----------------------ATASAEDTSKLCQDEIPSAETYN 414
L ++ +A + + YH A ++ ++ ++E+P T++
Sbjct: 441 LENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFD 500
Query: 415 LYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWR 474
+Y F F D + T+ D + ++M+ + +V KF IP +VL R++ S+ K YR + YHNWR
Sbjct: 501 IYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWR 560
Query: 475 HALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY 534
H NVAQTMF +L TGK++ + +DLE ++ A LCHD+DHRGTNN +Q K+++PLA L+
Sbjct: 561 HGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLH 620
Query: 535 STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFL 594
+S +E HH + +L+ E+ NI+Q L+ R ++ V+H+++ AI++TDLA+YFKK++ F
Sbjct: 621 GSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQ 680
Query: 595 ELVDNGEFDWQAQE-----------KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADE 643
++VD + ++Q ++ +KE++ MMMTACD+SAI KPWEVQ ++A LVA E
Sbjct: 681 KIVDESK-NYQDKKSWVEILSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAE 739
Query: 644 FFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTG 703
F++QGDLE+ L+QQPI MMDR K ELP++QVGFID +C +YK S + P+
Sbjct: 740 FWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDR 799
Query: 704 TADNRRRWQDLAEKVD 719
+NR+ W+ LA++ +
Sbjct: 800 LQNNRKEWKALADEYE 815
Score = 34.3 bits (75), Expect = 1.9
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Query: 56 FNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLD 104
F+S D T YKT+ +L PI N + DVV V +NK +G T D
Sbjct: 160 FSSFADELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDED 207
Score = 31.9 bits (69), Expect = 9.9
Identities = 13/33 (39%), Positives = 22/33 (66%)
Query: 64 TGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+G+ + +L MPI N + ++VGVA N+ DG+
Sbjct: 376 SGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGK 408
>BT009794-1|AAP88796.1| 853|Homo sapiens phosphodiesterase 6B,
cGMP-specific, rod, beta (congenital stationary night
bli protein.
Length = 853
Score = 367 bits (903), Expect = e-101
Identities = 209/615 (33%), Positives = 336/615 (54%), Gaps = 45/615 (7%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+S D +VF +YL F + ++ L E +R Q+LL A +FEE +++E K
Sbjct: 201 FTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKA 260
Query: 210 MTEARDLLKCERCAVFILD-TDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXXTRF 268
R L CER +V +LD T E + ++
Sbjct: 261 FYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYI 320
Query: 269 ----HTVFELGAPRRPHDALPA-IALAVARSNKSLNI--SDVEQWLRDNNMSAGENSAGV 321
+ + P H AL + + VA S NI + ++ + + ++ +
Sbjct: 321 LHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLI 380
Query: 322 RTLLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACK 376
+ +L MPIVN ++++GVA N+ F E D + E+ F G + NT Y+ K
Sbjct: 381 KNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNK 440
Query: 377 LMAKQKVALECLSYH----------------------ATASAEDTSKLCQDEIPSAETYN 414
L ++ +A + + YH A ++ ++ ++E+P T++
Sbjct: 441 LENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFD 500
Query: 415 LYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWR 474
+Y F F D + T+ D + ++M+ + +V KF IP +VL R++ S+ K YR + YHNWR
Sbjct: 501 IYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWR 560
Query: 475 HALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY 534
H NVAQTMF +L TGK++ + +DLE ++ A LCHD+DHRGTNN +Q K+++PLA L+
Sbjct: 561 HGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLH 620
Query: 535 STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFL 594
+S +E HH + +L+ E+ NI+Q L+ R + V+H+++ AI++TDLA+YFKK++ F
Sbjct: 621 GSSILERHHLEFGKFLLSEETLNIYQNLNRRQHDHVIHLMDIAIIATDLALYFKKRAMFQ 680
Query: 595 ELVDNGE--------FDWQAQE--KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEF 644
++VD + ++ + E +KE++ MMMTACD+SAI KPWEVQ ++A LVA EF
Sbjct: 681 KIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEF 740
Query: 645 FDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGT 704
++QGDLE+ L+QQPI MMDR K ELP++QVGFID +C +YK S + P+
Sbjct: 741 WEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRL 800
Query: 705 ADNRRRWQDLAEKVD 719
+NR+ W+ LA++ +
Sbjct: 801 QNNRKEWKALADEYE 815
Score = 34.3 bits (75), Expect = 1.9
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Query: 56 FNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLD 104
F+S D T YKT+ +L PI N + DVV V +NK +G T D
Sbjct: 160 FSSFADELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDED 207
Score = 31.9 bits (69), Expect = 9.9
Identities = 13/33 (39%), Positives = 22/33 (66%)
Query: 64 TGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+G+ + +L MPI N + ++VGVA N+ DG+
Sbjct: 376 SGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGK 408
>BC000249-1|AAH00249.1| 853|Homo sapiens phosphodiesterase 6B,
cGMP-specific, rod, beta (congenital stationary night
bli protein.
Length = 853
Score = 367 bits (903), Expect = e-101
Identities = 209/615 (33%), Positives = 336/615 (54%), Gaps = 45/615 (7%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+S D +VF +YL F + ++ L E +R Q+LL A +FEE +++E K
Sbjct: 201 FTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKA 260
Query: 210 MTEARDLLKCERCAVFILD-TDHCESSHLERIVQXXXXXXXXXXXXXXXXXXXXXXXTRF 268
R L CER +V +LD T E + ++
Sbjct: 261 FYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYI 320
Query: 269 ----HTVFELGAPRRPHDALPA-IALAVARSNKSLNI--SDVEQWLRDNNMSAGENSAGV 321
+ + P H AL + + VA S NI + ++ + + ++ +
Sbjct: 321 LHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLI 380
Query: 322 RTLLCMPIVNANKDVIGVAQLINK-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACK 376
+ +L MPIVN ++++GVA N+ F E D + E+ F G + NT Y+ K
Sbjct: 381 KNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNK 440
Query: 377 LMAKQKVALECLSYH----------------------ATASAEDTSKLCQDEIPSAETYN 414
L ++ +A + + YH A ++ ++ ++E+P T++
Sbjct: 441 LENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFD 500
Query: 415 LYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWR 474
+Y F F D + T+ D + ++M+ + +V KF IP +VL R++ S+ K YR + YHNWR
Sbjct: 501 IYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWR 560
Query: 475 HALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY 534
H NVAQTMF +L TGK++ + +DLE ++ A LCHD+DHRGTNN +Q K+++PLA L+
Sbjct: 561 HGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLH 620
Query: 535 STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFL 594
+S +E HH + +L+ E+ NI+Q L+ R + V+H+++ AI++TDLA+YFKK++ F
Sbjct: 621 GSSILERHHLEFGKFLLSEETLNIYQNLNRRQHDHVIHLMDIAIIATDLALYFKKRAMFQ 680
Query: 595 ELVDNGE--------FDWQAQE--KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEF 644
++VD + ++ + E +KE++ MMMTACD+SAI KPWEVQ ++A LVA EF
Sbjct: 681 KIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEF 740
Query: 645 FDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGT 704
++QGDLE+ L+QQPI MMDR K ELP++QVGFID +C +YK S + P+
Sbjct: 741 WEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRL 800
Query: 705 ADNRRRWQDLAEKVD 719
+NR+ W+ LA++ +
Sbjct: 801 QNNRKEWKALADEYE 815
Score = 34.3 bits (75), Expect = 1.9
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Query: 56 FNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLD 104
F+S D T YKT+ +L PI N + DVV V +NK +G T D
Sbjct: 160 FSSFADELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDED 207
Score = 31.9 bits (69), Expect = 9.9
Identities = 13/33 (39%), Positives = 22/33 (66%)
Query: 64 TGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+G+ + +L MPI N + ++VGVA N+ DG+
Sbjct: 376 SGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGK 408
>X90587-1|CAA62215.1| 617|Homo sapiens Rod cGMP phosphodiesterase
protein.
Length = 617
Score = 349 bits (858), Expect = 2e-95
Identities = 197/578 (34%), Positives = 318/578 (55%), Gaps = 45/578 (7%)
Query: 187 ILLALARSIFEEQSNLECLVTKIMTEARDLLKCERCAVFILD-TDHCESSHLERIVQXXX 245
+LL A +FEE +++E K R L CER +V +LD T E + ++
Sbjct: 1 VLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGES 60
Query: 246 XXXXXXXXXXXXXXXXXXXXTRF----HTVFELGAPRRPHDALPA-IALAVARSNKSLNI 300
+ + P H AL + + VA S NI
Sbjct: 61 QPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNI 120
Query: 301 --SDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK-----FTEGDVSI 353
+ ++ + + ++ ++ +L MPIVN ++++GVA N+ F E D +
Sbjct: 121 MNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVL 180
Query: 354 FEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYH---------------------- 391
E+ F G + NT Y+ KL ++ +A + + YH
Sbjct: 181 MESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEP 240
Query: 392 ATASAEDTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPY 451
A ++ ++ ++E+P T+++Y F F D + T+ D + ++M+ + +V KF IP
Sbjct: 241 ADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQ 300
Query: 452 DVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCH 511
+VL R++ S+ K YR + YHNWRH NVAQTMF +L TGK++ + +DLE ++ A LCH
Sbjct: 301 EVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCH 360
Query: 512 DLDHRGTNNAFQTKTESPLAILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVM 571
D+DHRGTNN +Q K+++PLA L+ +S +E HH + +L+ E+ NI+Q L+ R ++ V+
Sbjct: 361 DIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVI 420
Query: 572 HVVETAILSTDLAMYFKKKSKFLELVDNGE--------FDWQAQE--KKELLCGMMMTAC 621
H+++ AI++TDLA+YFKK++ F ++VD + ++ + E +KE++ MMMTAC
Sbjct: 421 HLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTAC 480
Query: 622 DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDT 681
D+SAI KPWEVQ ++A LVA EF++QGDLE+ L+QQPI MMDR K ELP++QVGFID
Sbjct: 481 DLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDF 540
Query: 682 ICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEKVD 719
+C +YK S + P+ +NR+ W+ LA++ +
Sbjct: 541 VCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 578
Score = 31.9 bits (69), Expect = 9.9
Identities = 13/33 (39%), Positives = 22/33 (66%)
Query: 64 TGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+G+ + +L MPI N + ++VGVA N+ DG+
Sbjct: 139 SGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGK 171
>BC104860-1|AAI04861.1| 779|Homo sapiens phosphodiesterase 10A
protein.
Length = 779
Score = 317 bits (779), Expect = 9e-86
Identities = 173/449 (38%), Positives = 250/449 (55%), Gaps = 13/449 (2%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK- 345
IA VAR+ + LNI D R N R +LCMPIV+ VIGV Q++NK
Sbjct: 330 IAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKI 388
Query: 346 ----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSK 401
F++ D + F+ FA+FC L +H MY +V +E LSYH+ ++E+
Sbjct: 389 SGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQG 448
Query: 402 LCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSV 461
L Q +P + F F D+ + + +++ + LCR+I+SV
Sbjct: 449 LMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSV 505
Query: 462 KKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNA 521
KKNYR V YHNW+HA+ VA M+A+L+ +DLE GLL+ACLCHDLDHRG +N+
Sbjct: 506 KKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNS 563
Query: 522 FQTKTESPLAILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILST 581
+ K + PLA LYSTSTME HHF Q V IL E +NIF LS +Y+ V+ ++ AI++T
Sbjct: 564 YLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT 623
Query: 582 DLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVA 641
DLA+YF + + E+ G + Q ++ + G+MMTACD+ ++ K W V A +
Sbjct: 624 DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIY 683
Query: 642 DEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLR 701
EF+ +GD E +L QPI MMDR+KKDE+PQ Q+GF + + +P Y L+ P PL
Sbjct: 684 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 742
Query: 702 TGTADNRRRWQDLAEKVDMGLTWIDHDTI 730
DN +W+ + + TWI ++
Sbjct: 743 KACRDNLSQWEKVIRGEETA-TWISSPSV 770
Score = 50.4 bits (115), Expect = 3e-05
Identities = 25/58 (43%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 51 YITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLDHNYE 108
Y +FN E+D TGY T ILCMPI + G V+GV Q++NK G T ++N++
Sbjct: 347 YADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVVQMVNKISGS-AFSKTDENNFK 402
Score = 42.7 bits (96), Expect = 0.005
Identities = 22/85 (25%), Positives = 42/85 (49%)
Query: 144 HSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLE 203
H G + F EV L + + I Q+ + + N LL ++++ F+ ++
Sbjct: 209 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 268
Query: 204 CLVTKIMTEARDLLKCERCAVFILD 228
L+ IM A++L+ +RCA+F +D
Sbjct: 269 SLLEHIMIYAKNLVNADRCALFQVD 293
Score = 37.9 bits (84), Expect = 0.15
Identities = 29/110 (26%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 277 PRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDV 336
P P ++ VA+S K+L + D+ R + E+ ++++LC+PIV A D+
Sbjct: 141 PAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDL 200
Query: 337 IGVAQLI-----NKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQ 381
IG+ +L F + A + + IH Q+ C+ +AKQ
Sbjct: 201 IGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQV----CRGLAKQ 246
>BC104858-1|AAI04859.1| 779|Homo sapiens phosphodiesterase 10A
protein.
Length = 779
Score = 317 bits (779), Expect = 9e-86
Identities = 173/449 (38%), Positives = 250/449 (55%), Gaps = 13/449 (2%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK- 345
IA VAR+ + LNI D R N R +LCMPIV+ VIGV Q++NK
Sbjct: 330 IAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKI 388
Query: 346 ----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSK 401
F++ D + F+ FA+FC L +H MY +V +E LSYH+ ++E+
Sbjct: 389 SGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQG 448
Query: 402 LCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSV 461
L Q +P + F F D+ + + +++ + LCR+I+SV
Sbjct: 449 LMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSV 505
Query: 462 KKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNA 521
KKNYR V YHNW+HA+ VA M+A+L+ +DLE GLL+ACLCHDLDHRG +N+
Sbjct: 506 KKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNS 563
Query: 522 FQTKTESPLAILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILST 581
+ K + PLA LYSTSTME HHF Q V IL E +NIF LS +Y+ V+ ++ AI++T
Sbjct: 564 YLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT 623
Query: 582 DLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVA 641
DLA+YF + + E+ G + Q ++ + G+MMTACD+ ++ K W V A +
Sbjct: 624 DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIY 683
Query: 642 DEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLR 701
EF+ +GD E +L QPI MMDR+KKDE+PQ Q+GF + + +P Y L+ P PL
Sbjct: 684 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 742
Query: 702 TGTADNRRRWQDLAEKVDMGLTWIDHDTI 730
DN +W+ + + TWI ++
Sbjct: 743 KACRDNLSQWEKVIRGEETA-TWISSPSV 770
Score = 50.4 bits (115), Expect = 3e-05
Identities = 25/58 (43%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 51 YITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLDHNYE 108
Y +FN E+D TGY T ILCMPI + G V+GV Q++NK G T ++N++
Sbjct: 347 YADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVVQMVNKISGS-AFSKTDENNFK 402
Score = 42.7 bits (96), Expect = 0.005
Identities = 22/85 (25%), Positives = 42/85 (49%)
Query: 144 HSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLE 203
H G + F EV L + + I Q+ + + N LL ++++ F+ ++
Sbjct: 209 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 268
Query: 204 CLVTKIMTEARDLLKCERCAVFILD 228
L+ IM A++L+ +RCA+F +D
Sbjct: 269 SLLEHIMIYAKNLVNADRCALFQVD 293
Score = 37.9 bits (84), Expect = 0.15
Identities = 29/110 (26%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 277 PRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDV 336
P P ++ VA+S K+L + D+ R + E+ ++++LC+PIV A D+
Sbjct: 141 PAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDL 200
Query: 337 IGVAQLI-----NKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQ 381
IG+ +L F + A + + IH Q+ C+ +AKQ
Sbjct: 201 IGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQV----CRGLAKQ 246
>AL160160-1|CAH72023.1| 779|Homo sapiens phosphodiesterase 10A
protein.
Length = 779
Score = 317 bits (779), Expect = 9e-86
Identities = 173/449 (38%), Positives = 250/449 (55%), Gaps = 13/449 (2%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK- 345
IA VAR+ + LNI D R N R +LCMPIV+ VIGV Q++NK
Sbjct: 330 IAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKI 388
Query: 346 ----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSK 401
F++ D + F+ FA+FC L +H MY +V +E LSYH+ ++E+
Sbjct: 389 SGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQG 448
Query: 402 LCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSV 461
L Q +P + F F D+ + + +++ + LCR+I+SV
Sbjct: 449 LMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSV 505
Query: 462 KKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNA 521
KKNYR V YHNW+HA+ VA M+A+L+ +DLE GLL+ACLCHDLDHRG +N+
Sbjct: 506 KKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNS 563
Query: 522 FQTKTESPLAILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILST 581
+ K + PLA LYSTSTME HHF Q V IL E +NIF LS +Y+ V+ ++ AI++T
Sbjct: 564 YLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT 623
Query: 582 DLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVA 641
DLA+YF + + E+ G + Q ++ + G+MMTACD+ ++ K W V A +
Sbjct: 624 DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIY 683
Query: 642 DEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLR 701
EF+ +GD E +L QPI MMDR+KKDE+PQ Q+GF + + +P Y L+ P PL
Sbjct: 684 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 742
Query: 702 TGTADNRRRWQDLAEKVDMGLTWIDHDTI 730
DN +W+ + + TWI ++
Sbjct: 743 KACRDNLSQWEKVIRGEETA-TWISSPSV 770
Score = 50.4 bits (115), Expect = 3e-05
Identities = 25/58 (43%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 51 YITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLDHNYE 108
Y +FN E+D TGY T ILCMPI + G V+GV Q++NK G T ++N++
Sbjct: 347 YADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVVQMVNKISGS-AFSKTDENNFK 402
Score = 42.7 bits (96), Expect = 0.005
Identities = 22/85 (25%), Positives = 42/85 (49%)
Query: 144 HSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLE 203
H G + F EV L + + I Q+ + + N LL ++++ F+ ++
Sbjct: 209 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 268
Query: 204 CLVTKIMTEARDLLKCERCAVFILD 228
L+ IM A++L+ +RCA+F +D
Sbjct: 269 SLLEHIMIYAKNLVNADRCALFQVD 293
Score = 37.9 bits (84), Expect = 0.15
Identities = 29/110 (26%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 277 PRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDV 336
P P ++ VA+S K+L + D+ R + E+ ++++LC+PIV A D+
Sbjct: 141 PAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDL 200
Query: 337 IGVAQLI-----NKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQ 381
IG+ +L F + A + + IH Q+ C+ +AKQ
Sbjct: 201 IGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQV----CRGLAKQ 246
>AL136130-1|CAI20436.1| 779|Homo sapiens phosphodiesterase 10A
protein.
Length = 779
Score = 317 bits (779), Expect = 9e-86
Identities = 173/449 (38%), Positives = 250/449 (55%), Gaps = 13/449 (2%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK- 345
IA VAR+ + LNI D R N R +LCMPIV+ VIGV Q++NK
Sbjct: 330 IAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKI 388
Query: 346 ----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSK 401
F++ D + F+ FA+FC L +H MY +V +E LSYH+ ++E+
Sbjct: 389 SGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQG 448
Query: 402 LCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSV 461
L Q +P + F F D+ + + +++ + LCR+I+SV
Sbjct: 449 LMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSV 505
Query: 462 KKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNA 521
KKNYR V YHNW+HA+ VA M+A+L+ +DLE GLL+ACLCHDLDHRG +N+
Sbjct: 506 KKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNS 563
Query: 522 FQTKTESPLAILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILST 581
+ K + PLA LYSTSTME HHF Q V IL E +NIF LS +Y+ V+ ++ AI++T
Sbjct: 564 YLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT 623
Query: 582 DLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVA 641
DLA+YF + + E+ G + Q ++ + G+MMTACD+ ++ K W V A +
Sbjct: 624 DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIY 683
Query: 642 DEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLR 701
EF+ +GD E +L QPI MMDR+KKDE+PQ Q+GF + + +P Y L+ P PL
Sbjct: 684 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 742
Query: 702 TGTADNRRRWQDLAEKVDMGLTWIDHDTI 730
DN +W+ + + TWI ++
Sbjct: 743 KACRDNLSQWEKVIRGEETA-TWISSPSV 770
Score = 50.4 bits (115), Expect = 3e-05
Identities = 25/58 (43%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 51 YITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLDHNYE 108
Y +FN E+D TGY T ILCMPI + G V+GV Q++NK G T ++N++
Sbjct: 347 YADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVVQMVNKISGS-AFSKTDENNFK 402
Score = 42.7 bits (96), Expect = 0.005
Identities = 22/85 (25%), Positives = 42/85 (49%)
Query: 144 HSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLE 203
H G + F EV L + + I Q+ + + N LL ++++ F+ ++
Sbjct: 209 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 268
Query: 204 CLVTKIMTEARDLLKCERCAVFILD 228
L+ IM A++L+ +RCA+F +D
Sbjct: 269 SLLEHIMIYAKNLVNADRCALFQVD 293
Score = 37.9 bits (84), Expect = 0.15
Identities = 29/110 (26%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 277 PRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDV 336
P P ++ VA+S K+L + D+ R + E+ ++++LC+PIV A D+
Sbjct: 141 PAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDL 200
Query: 337 IGVAQLI-----NKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQ 381
IG+ +L F + A + + IH Q+ C+ +AKQ
Sbjct: 201 IGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQV----CRGLAKQ 246
>AL117345-1|CAB92797.2| 779|Homo sapiens phosphodiesterase 10A
protein.
Length = 779
Score = 317 bits (779), Expect = 9e-86
Identities = 173/449 (38%), Positives = 250/449 (55%), Gaps = 13/449 (2%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK- 345
IA VAR+ + LNI D R N R +LCMPIV+ VIGV Q++NK
Sbjct: 330 IAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKI 388
Query: 346 ----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSK 401
F++ D + F+ FA+FC L +H MY +V +E LSYH+ ++E+
Sbjct: 389 SGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQG 448
Query: 402 LCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSV 461
L Q +P + F F D+ + + +++ + LCR+I+SV
Sbjct: 449 LMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSV 505
Query: 462 KKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNA 521
KKNYR V YHNW+HA+ VA M+A+L+ +DLE GLL+ACLCHDLDHRG +N+
Sbjct: 506 KKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNS 563
Query: 522 FQTKTESPLAILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILST 581
+ K + PLA LYSTSTME HHF Q V IL E +NIF LS +Y+ V+ ++ AI++T
Sbjct: 564 YLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT 623
Query: 582 DLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVA 641
DLA+YF + + E+ G + Q ++ + G+MMTACD+ ++ K W V A +
Sbjct: 624 DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIY 683
Query: 642 DEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLR 701
EF+ +GD E +L QPI MMDR+KKDE+PQ Q+GF + + +P Y L+ P PL
Sbjct: 684 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 742
Query: 702 TGTADNRRRWQDLAEKVDMGLTWIDHDTI 730
DN +W+ + + TWI ++
Sbjct: 743 KACRDNLSQWEKVIRGEETA-TWISSPSV 770
Score = 50.4 bits (115), Expect = 3e-05
Identities = 25/58 (43%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 51 YITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLDHNYE 108
Y +FN E+D TGY T ILCMPI + G V+GV Q++NK G T ++N++
Sbjct: 347 YADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVVQMVNKISGS-AFSKTDENNFK 402
Score = 42.7 bits (96), Expect = 0.005
Identities = 22/85 (25%), Positives = 42/85 (49%)
Query: 144 HSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLE 203
H G + F EV L + + I Q+ + + N LL ++++ F+ ++
Sbjct: 209 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 268
Query: 204 CLVTKIMTEARDLLKCERCAVFILD 228
L+ IM A++L+ +RCA+F +D
Sbjct: 269 SLLEHIMIYAKNLVNADRCALFQVD 293
Score = 37.9 bits (84), Expect = 0.15
Identities = 29/110 (26%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 277 PRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDV 336
P P ++ VA+S K+L + D+ R + E+ ++++LC+PIV A D+
Sbjct: 141 PAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDL 200
Query: 337 IGVAQLI-----NKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQ 381
IG+ +L F + A + + IH Q+ C+ +AKQ
Sbjct: 201 IGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQV----CRGLAKQ 246
>AF127480-1|AAD32596.1| 807|Homo sapiens 3',5'-cyclic nucleotide
phosphodiesterase 10A2 protein.
Length = 807
Score = 317 bits (779), Expect = 9e-86
Identities = 173/449 (38%), Positives = 250/449 (55%), Gaps = 13/449 (2%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK- 345
IA VAR+ + LNI D R N R +LCMPIV+ VIGV Q++NK
Sbjct: 358 IAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKI 416
Query: 346 ----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSK 401
F++ D + F+ FA+FC L +H MY +V +E LSYH+ ++E+
Sbjct: 417 SGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQG 476
Query: 402 LCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSV 461
L Q +P + F F D+ + + +++ + LCR+I+SV
Sbjct: 477 LMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSV 533
Query: 462 KKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNA 521
KKNYR V YHNW+HA+ VA M+A+L+ +DLE GLL+ACLCHDLDHRG +N+
Sbjct: 534 KKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNS 591
Query: 522 FQTKTESPLAILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILST 581
+ K + PLA LYSTSTME HHF Q V IL E +NIF LS +Y+ V+ ++ AI++T
Sbjct: 592 YLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT 651
Query: 582 DLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVA 641
DLA+YF + + E+ G + Q ++ + G+MMTACD+ ++ K W V A +
Sbjct: 652 DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIY 711
Query: 642 DEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLR 701
EF+ +GD E +L QPI MMDR+KKDE+PQ Q+GF + + +P Y L+ P PL
Sbjct: 712 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 770
Query: 702 TGTADNRRRWQDLAEKVDMGLTWIDHDTI 730
DN +W+ + + TWI ++
Sbjct: 771 KACRDNLSQWEKVIRGEETA-TWISSPSV 798
Score = 50.4 bits (115), Expect = 3e-05
Identities = 25/58 (43%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 51 YITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLDHNYE 108
Y +FN E+D TGY T ILCMPI + G V+GV Q++NK G T ++N++
Sbjct: 375 YADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVVQMVNKISGS-AFSKTDENNFK 430
Score = 42.7 bits (96), Expect = 0.005
Identities = 22/85 (25%), Positives = 42/85 (49%)
Query: 144 HSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLE 203
H G + F EV L + + I Q+ + + N LL ++++ F+ ++
Sbjct: 237 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 296
Query: 204 CLVTKIMTEARDLLKCERCAVFILD 228
L+ IM A++L+ +RCA+F +D
Sbjct: 297 SLLEHIMIYAKNLVNADRCALFQVD 321
Score = 37.9 bits (84), Expect = 0.15
Identities = 29/110 (26%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 277 PRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDV 336
P P ++ VA+S K+L + D+ R + E+ ++++LC+PIV A D+
Sbjct: 169 PAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDL 228
Query: 337 IGVAQLI-----NKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQ 381
IG+ +L F + A + + IH Q+ C+ +AKQ
Sbjct: 229 IGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQV----CRGLAKQ 274
>AF127479-1|AAD32595.1| 779|Homo sapiens 3',5'-cyclic nucleotide
phosphodiesterase 10A1 protein.
Length = 779
Score = 317 bits (779), Expect = 9e-86
Identities = 173/449 (38%), Positives = 250/449 (55%), Gaps = 13/449 (2%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK- 345
IA VAR+ + LNI D R N R +LCMPIV+ VIGV Q++NK
Sbjct: 330 IAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKI 388
Query: 346 ----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSK 401
F++ D + F+ FA+FC L +H MY +V +E LSYH+ ++E+
Sbjct: 389 SGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQG 448
Query: 402 LCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSV 461
L Q +P + F F D+ + + +++ + LCR+I+SV
Sbjct: 449 LMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSV 505
Query: 462 KKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNA 521
KKNYR V YHNW+HA+ VA M+A+L+ +DLE GLL+ACLCHDLDHRG +N+
Sbjct: 506 KKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNS 563
Query: 522 FQTKTESPLAILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILST 581
+ K + PLA LYSTSTME HHF Q V IL E +NIF LS +Y+ V+ ++ AI++T
Sbjct: 564 YLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT 623
Query: 582 DLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVA 641
DLA+YF + + E+ G + Q ++ + G+MMTACD+ ++ K W V A +
Sbjct: 624 DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIY 683
Query: 642 DEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLR 701
EF+ +GD E +L QPI MMDR+KKDE+PQ Q+GF + + +P Y L+ P PL
Sbjct: 684 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 742
Query: 702 TGTADNRRRWQDLAEKVDMGLTWIDHDTI 730
DN +W+ + + TWI ++
Sbjct: 743 KACRDNLSQWEKVIRGEETA-TWISSPSV 770
Score = 50.4 bits (115), Expect = 3e-05
Identities = 25/58 (43%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 51 YITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLDHNYE 108
Y +FN E+D TGY T ILCMPI + G V+GV Q++NK G T ++N++
Sbjct: 347 YADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVVQMVNKISGS-AFSKTDENNFK 402
Score = 42.7 bits (96), Expect = 0.005
Identities = 22/85 (25%), Positives = 42/85 (49%)
Query: 144 HSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLE 203
H G + F EV L + + I Q+ + + N LL ++++ F+ ++
Sbjct: 209 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 268
Query: 204 CLVTKIMTEARDLLKCERCAVFILD 228
L+ IM A++L+ +RCA+F +D
Sbjct: 269 SLLEHIMIYAKNLVNADRCALFQVD 293
Score = 37.9 bits (84), Expect = 0.15
Identities = 29/110 (26%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 277 PRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDV 336
P P ++ VA+S K+L + D+ R + E+ ++++LC+PIV A D+
Sbjct: 141 PAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDL 200
Query: 337 IGVAQLI-----NKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQ 381
IG+ +L F + A + + IH Q+ C+ +AKQ
Sbjct: 201 IGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQV----CRGLAKQ 246
>AB041798-3|BAB16383.1| 714|Homo sapiens phosphodiesterase 10A1
(PDE10A1) protein.
Length = 714
Score = 317 bits (779), Expect = 9e-86
Identities = 173/449 (38%), Positives = 250/449 (55%), Gaps = 13/449 (2%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK- 345
IA VAR+ + LNI D R N R +LCMPIV+ VIGV Q++NK
Sbjct: 265 IAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKI 323
Query: 346 ----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSK 401
F++ D + F+ FA+FC L +H MY +V +E LSYH+ ++E+
Sbjct: 324 SGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQG 383
Query: 402 LCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSV 461
L Q +P + F F D+ + + +++ + LCR+I+SV
Sbjct: 384 LMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSV 440
Query: 462 KKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNA 521
KKNYR V YHNW+HA+ VA M+A+L+ +DLE GLL+ACLCHDLDHRG +N+
Sbjct: 441 KKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNS 498
Query: 522 FQTKTESPLAILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILST 581
+ K + PLA LYSTSTME HHF Q V IL E +NIF LS +Y+ V+ ++ AI++T
Sbjct: 499 YLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT 558
Query: 582 DLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVA 641
DLA+YF + + E+ G + Q ++ + G+MMTACD+ ++ K W V A +
Sbjct: 559 DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIY 618
Query: 642 DEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLR 701
EF+ +GD E +L QPI MMDR+KKDE+PQ Q+GF + + +P Y L+ P PL
Sbjct: 619 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 677
Query: 702 TGTADNRRRWQDLAEKVDMGLTWIDHDTI 730
DN +W+ + + TWI ++
Sbjct: 678 KACRDNLSQWEKVIRGEETA-TWISSPSV 705
Score = 50.4 bits (115), Expect = 3e-05
Identities = 25/58 (43%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 51 YITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLDHNYE 108
Y +FN E+D TGY T ILCMPI + G V+GV Q++NK G T ++N++
Sbjct: 282 YADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVVQMVNKISGS-AFSKTDENNFK 337
Score = 42.7 bits (96), Expect = 0.005
Identities = 22/85 (25%), Positives = 42/85 (49%)
Query: 144 HSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLE 203
H G + F EV L + + I Q+ + + N LL ++++ F+ ++
Sbjct: 144 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 203
Query: 204 CLVTKIMTEARDLLKCERCAVFILD 228
L+ IM A++L+ +RCA+F +D
Sbjct: 204 SLLEHIMIYAKNLVNADRCALFQVD 228
Score = 37.9 bits (84), Expect = 0.15
Identities = 29/110 (26%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 277 PRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDV 336
P P ++ VA+S K+L + D+ R + E+ ++++LC+PIV A D+
Sbjct: 76 PAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDL 135
Query: 337 IGVAQLI-----NKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQ 381
IG+ +L F + A + + IH Q+ C+ +AKQ
Sbjct: 136 IGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQV----CRGLAKQ 181
>AB026816-1|BAA84467.1| 789|Homo sapiens 3',5'-cyclic nucleotide
phosphodiesterase 10A2 protein.
Length = 789
Score = 317 bits (779), Expect = 9e-86
Identities = 173/449 (38%), Positives = 250/449 (55%), Gaps = 13/449 (2%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK- 345
IA VAR+ + LNI D R N R +LCMPIV+ VIGV Q++NK
Sbjct: 340 IAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKI 398
Query: 346 ----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSK 401
F++ D + F+ FA+FC L +H MY +V +E LSYH+ ++E+
Sbjct: 399 SGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQG 458
Query: 402 LCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSV 461
L Q +P + F F D+ + + +++ + LCR+I+SV
Sbjct: 459 LMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSV 515
Query: 462 KKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNA 521
KKNYR V YHNW+HA+ VA M+A+L+ +DLE GLL+ACLCHDLDHRG +N+
Sbjct: 516 KKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNS 573
Query: 522 FQTKTESPLAILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILST 581
+ K + PLA LYSTSTME HHF Q V IL E +NIF LS +Y+ V+ ++ AI++T
Sbjct: 574 YLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT 633
Query: 582 DLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVA 641
DLA+YF + + E+ G + Q ++ + G+MMTACD+ ++ K W V A +
Sbjct: 634 DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIY 693
Query: 642 DEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLR 701
EF+ +GD E +L QPI MMDR+KKDE+PQ Q+GF + + +P Y L+ P PL
Sbjct: 694 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 752
Query: 702 TGTADNRRRWQDLAEKVDMGLTWIDHDTI 730
DN +W+ + + TWI ++
Sbjct: 753 KACRDNLSQWEKVIRGEETA-TWISSPSV 780
Score = 50.4 bits (115), Expect = 3e-05
Identities = 25/58 (43%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 51 YITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLDHNYE 108
Y +FN E+D TGY T ILCMPI + G V+GV Q++NK G T ++N++
Sbjct: 357 YADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVVQMVNKISGS-AFSKTDENNFK 412
Score = 42.7 bits (96), Expect = 0.005
Identities = 22/85 (25%), Positives = 42/85 (49%)
Query: 144 HSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLE 203
H G + F EV L + + I Q+ + + N LL ++++ F+ ++
Sbjct: 219 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 278
Query: 204 CLVTKIMTEARDLLKCERCAVFILD 228
L+ IM A++L+ +RCA+F +D
Sbjct: 279 SLLEHIMIYAKNLVNADRCALFQVD 303
Score = 37.9 bits (84), Expect = 0.15
Identities = 29/110 (26%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 277 PRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDV 336
P P ++ VA+S K+L + D+ R + E+ ++++LC+PIV A D+
Sbjct: 151 PAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDL 210
Query: 337 IGVAQLI-----NKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQ 381
IG+ +L F + A + + IH Q+ C+ +AKQ
Sbjct: 211 IGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQV----CRGLAKQ 256
>AB020593-1|BAA78034.1| 779|Homo sapiens 3',5'-Cyclic nucleotide
phosphodiesterase protein.
Length = 779
Score = 317 bits (779), Expect = 9e-86
Identities = 173/449 (38%), Positives = 250/449 (55%), Gaps = 13/449 (2%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK- 345
IA VAR+ + LNI D R N R +LCMPIV+ VIGV Q++NK
Sbjct: 330 IAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKI 388
Query: 346 ----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSK 401
F++ D + F+ FA+FC L +H MY +V +E LSYH+ ++E+
Sbjct: 389 SGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQG 448
Query: 402 LCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSV 461
L Q +P + F F D+ + + +++ + LCR+I+SV
Sbjct: 449 LMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSV 505
Query: 462 KKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNA 521
KKNYR V YHNW+HA+ VA M+A+L+ +DLE GLL+ACLCHDLDHRG +N+
Sbjct: 506 KKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNS 563
Query: 522 FQTKTESPLAILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILST 581
+ K + PLA LYSTSTME HHF Q V IL E +NIF LS +Y+ V+ ++ AI++T
Sbjct: 564 YLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT 623
Query: 582 DLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVA 641
DLA+YF + + E+ G + Q ++ + G+MMTACD+ ++ K W V A +
Sbjct: 624 DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIY 683
Query: 642 DEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLR 701
EF+ +GD E +L QPI MMDR+KKDE+PQ Q+GF + + +P Y L+ P PL
Sbjct: 684 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 742
Query: 702 TGTADNRRRWQDLAEKVDMGLTWIDHDTI 730
DN +W+ + + TWI ++
Sbjct: 743 KACRDNLSQWEKVIRGEETA-TWISSPSV 770
Score = 50.4 bits (115), Expect = 3e-05
Identities = 25/58 (43%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 51 YITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLDHNYE 108
Y +FN E+D TGY T ILCMPI + G V+GV Q++NK G T ++N++
Sbjct: 347 YADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVVQMVNKISGS-AFSKTDENNFK 402
Score = 42.7 bits (96), Expect = 0.005
Identities = 22/85 (25%), Positives = 42/85 (49%)
Query: 144 HSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLE 203
H G + F EV L + + I Q+ + + N LL ++++ F+ ++
Sbjct: 209 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 268
Query: 204 CLVTKIMTEARDLLKCERCAVFILD 228
L+ IM A++L+ +RCA+F +D
Sbjct: 269 SLLEHIMIYAKNLVNADRCALFQVD 293
Score = 37.9 bits (84), Expect = 0.15
Identities = 29/110 (26%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 277 PRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDV 336
P P ++ VA+S K+L + D+ R + E+ ++++LC+PIV A D+
Sbjct: 141 PAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDL 200
Query: 337 IGVAQLI-----NKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQ 381
IG+ +L F + A + + IH Q+ C+ +AKQ
Sbjct: 201 IGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQV----CRGLAKQ 246
>CR536567-1|CAG38804.1| 779|Homo sapiens PDE10A protein.
Length = 779
Score = 315 bits (773), Expect = 5e-85
Identities = 172/449 (38%), Positives = 249/449 (55%), Gaps = 13/449 (2%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK- 345
IA VAR+ + LNI D R N R +LCMPIV+ VIGV Q++NK
Sbjct: 330 IAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKI 388
Query: 346 ----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSK 401
F++ D + F+ FA+FC L +H MY +V +E LSYH+ ++E+
Sbjct: 389 SGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQG 448
Query: 402 LCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSV 461
L Q +P + F F D+ + + +++ + LCR+I+SV
Sbjct: 449 LMQFTLPVRLCKEIELFHF---DIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSV 505
Query: 462 KKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNA 521
KKNYR V YHNW+HA+ VA M+A+L+ +DLE GLL+ACLCHDLDHRG +N+
Sbjct: 506 KKNYRRVPYHNWKHAVTVAHCMYAILQNN--HTLFTDLERKGLLIACLCHDLDHRGFSNS 563
Query: 522 FQTKTESPLAILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILST 581
+ K + PLA LYSTSTME HHF Q V IL E +NIF LS +Y+ V+ ++ AI++T
Sbjct: 564 YLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT 623
Query: 582 DLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVA 641
DLA+YF + + E+ G + Q ++ + +MMTACD+ ++ K W V A +
Sbjct: 624 DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVISLMMTACDLCSVTKLWPVTKLTANDIY 683
Query: 642 DEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLR 701
EF+ +GD E +L QPI MMDR+KKDE+PQ Q+GF + + +P Y L+ P PL
Sbjct: 684 AEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLL 742
Query: 702 TGTADNRRRWQDLAEKVDMGLTWIDHDTI 730
DN +W+ + + TWI ++
Sbjct: 743 KACRDNLSQWEKVIRGEETA-TWISSPSV 770
Score = 50.4 bits (115), Expect = 3e-05
Identities = 25/58 (43%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 51 YITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLDHNYE 108
Y +FN E+D TGY T ILCMPI + G V+GV Q++NK G T ++N++
Sbjct: 347 YADPRFNREVDLYTGYTTRNILCMPIVS-RGSVIGVVQMVNKISGS-AFSKTDENNFK 402
Score = 42.7 bits (96), Expect = 0.005
Identities = 22/85 (25%), Positives = 42/85 (49%)
Query: 144 HSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLE 203
H G + F EV L + + I Q+ + + N LL ++++ F+ ++
Sbjct: 209 HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAID 268
Query: 204 CLVTKIMTEARDLLKCERCAVFILD 228
L+ IM A++L+ +RCA+F +D
Sbjct: 269 SLLEHIMIYAKNLVNADRCALFQVD 293
Score = 37.9 bits (84), Expect = 0.15
Identities = 29/110 (26%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 277 PRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDV 336
P P ++ VA+S K+L + D+ R + E+ ++++LC+PIV A D+
Sbjct: 141 PAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDL 200
Query: 337 IGVAQLI-----NKFTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQ 381
IG+ +L F + A + + IH Q+ C+ +AKQ
Sbjct: 201 IGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQV----CRGLAKQ 246
>AC012499-1|AAY14803.1| 325|Homo sapiens unknown protein.
Length = 325
Score = 310 bits (761), Expect = 1e-83
Identities = 153/308 (49%), Positives = 204/308 (66%), Gaps = 6/308 (1%)
Query: 286 AIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK 345
+IA VA + +NISD Q R + + + +R++LC+PI N+N +IGVAQ++N+
Sbjct: 18 SIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNR 77
Query: 346 -----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTS 400
F + D +FEAF IFCGLGI+NT MY+ K AKQ VAL+ LSYHAT S +
Sbjct: 78 LDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVD 137
Query: 401 KLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILS 460
K IP + F DF L + A LRMF++ +V+KF I Y+ LCRW+L+
Sbjct: 138 KFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLT 197
Query: 461 VKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNN 520
V+KNYR V YHNWRHA NV Q MFAML T + ++++EIL ++V CLCHDLDHRGTNN
Sbjct: 198 VRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNN 257
Query: 521 AFQTKTESPLAILYSTS-TMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAIL 579
AFQ K+ S LA LY TS T+EHHHF+ VMIL SE +NIF LS ++Y D+M +++ +IL
Sbjct: 258 AFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSIL 317
Query: 580 STDLAMYF 587
+TDL +YF
Sbjct: 318 ATDLTLYF 325
Score = 44.0 bits (99), Expect = 0.002
Identities = 16/42 (38%), Positives = 29/42 (69%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGE 96
+F++E D +G+ +LC+PI N ++GVAQ++N+ DG+
Sbjct: 40 RFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 81
Score = 32.3 bits (70), Expect = 7.5
Identities = 12/48 (25%), Positives = 23/48 (47%)
Query: 142 LSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILL 189
L+ K F D +F ++ FCG+GI N +++ + + + L
Sbjct: 75 LNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 122
>U67733-1|AAC51320.1| 941|Homo sapiens PDE2A3 protein.
Length = 941
Score = 305 bits (748), Expect = 5e-82
Identities = 164/442 (37%), Positives = 253/442 (57%), Gaps = 16/442 (3%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRT--LLCMPIVNANKDVIGVAQLIN 344
IA VA + + LNI D + ++S G RT +LC PI N N++VIGVA+L+N
Sbjct: 465 IAGHVATTGQILNIPDA--YAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVN 522
Query: 345 K-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDT 399
K F++ D + AF+I+CG+ I ++ +Y+ + + +A E + YH S ++
Sbjct: 523 KINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEY 582
Query: 400 SKLCQDEIP--SAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
+KL D I +A N SF + L ++DT A L M + + I L R+
Sbjct: 583 TKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARF 642
Query: 458 ILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRG 517
L VKK YR YHNW HA +V+ + + K ++ ++ D+EI L ++C+CHDLDHRG
Sbjct: 643 CLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRG 702
Query: 518 TNNAFQTKTESPLAILYST--STMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
TNN+FQ ++S LA LYS+ S ME HHF Q + ILN+ NIF S +DY+ ++ ++
Sbjct: 703 TNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMR 762
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHR 635
IL+TDLA + + ++ + G +D ++ LL ++MT+CD+S K W+ +
Sbjct: 763 DIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRK 821
Query: 636 IAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFP 695
IA+L+ EFF QGDLEK + +P+ MMDREK +P++Q+ F++ I +P+YK+L D FP
Sbjct: 822 IAELIYKEFFSQGDLEK-AMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFP 879
Query: 696 WMTPLRTGTADNRRRWQDLAEK 717
L A NR W ++ K
Sbjct: 880 KAAELYERVASNREHWTKVSHK 901
Score = 44.4 bits (100), Expect = 0.002
Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 9/67 (13%)
Query: 29 ISTSGMHTPIPGKIPHKLTAIKYITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQ 88
++T+G IP H L F +D TG++T ILC PI N +V+GVA+
Sbjct: 469 VATTGQILNIPDAYAHPL---------FYRGVDDSTGFRTRNILCFPIKNENQEVIGVAE 519
Query: 89 IINKTDG 95
++NK +G
Sbjct: 520 LVNKING 526
Score = 41.5 bits (93), Expect = 0.012
Identities = 22/79 (27%), Positives = 40/79 (50%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+ D V + + + + F+ Q LL +A+++F ++ L+ +I
Sbjct: 358 FTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEI 417
Query: 210 MTEARDLLKCERCAVFILD 228
+TEAR+L E C+VF+LD
Sbjct: 418 ITEARNLSNAEICSVFLLD 436
>AK131525-1|BAD18664.1| 685|Homo sapiens protein ( Homo sapiens
cDNA FLJ16750 fis, clone ADRGL2011190, highly similar
to cGMP-dependent 3',5'-cyclic phosphodiesterase (EC
3.1.4.17). ).
Length = 685
Score = 305 bits (748), Expect = 5e-82
Identities = 164/442 (37%), Positives = 253/442 (57%), Gaps = 16/442 (3%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRT--LLCMPIVNANKDVIGVAQLIN 344
IA VA + + LNI D + ++S G RT +LC PI N N++VIGVA+L+N
Sbjct: 209 IAGHVATTGQILNIPDA--YAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVN 266
Query: 345 K-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDT 399
K F++ D + AF+I+CG+ I ++ +Y+ + + +A E + YH S ++
Sbjct: 267 KINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEY 326
Query: 400 SKLCQDEIP--SAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
+KL D I +A N SF + L ++DT A L M + + I L R+
Sbjct: 327 TKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARF 386
Query: 458 ILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRG 517
L VKK YR YHNW HA +V+ + + K ++ ++ D+EI L ++C+CHDLDHRG
Sbjct: 387 CLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRG 446
Query: 518 TNNAFQTKTESPLAILYST--STMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
TNN+FQ ++S LA LYS+ S ME HHF Q + ILN+ NIF S +DY+ ++ ++
Sbjct: 447 TNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMR 506
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHR 635
IL+TDLA + + ++ + G +D ++ LL ++MT+CD+S K W+ +
Sbjct: 507 DIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRK 565
Query: 636 IAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFP 695
IA+L+ EFF QGDLEK + +P+ MMDREK +P++Q+ F++ I +P+YK+L D FP
Sbjct: 566 IAELIYKEFFSQGDLEK-AMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFP 623
Query: 696 WMTPLRTGTADNRRRWQDLAEK 717
L A NR W ++ K
Sbjct: 624 KAAELYERVASNREHWTKVSHK 645
Score = 44.8 bits (101), Expect = 0.001
Identities = 24/88 (27%), Positives = 43/88 (48%)
Query: 141 KLSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQS 200
+L G F+ D V + + + + F+ Q LL +A+++F
Sbjct: 93 ELPQEGKVRFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLD 152
Query: 201 NLECLVTKIMTEARDLLKCERCAVFILD 228
++ L+ +I+TEAR+L E C+VF+LD
Sbjct: 153 DVSVLLQEIITEARNLSNAEICSVFLLD 180
Score = 44.4 bits (100), Expect = 0.002
Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 9/67 (13%)
Query: 29 ISTSGMHTPIPGKIPHKLTAIKYITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQ 88
++T+G IP H L F +D TG++T ILC PI N +V+GVA+
Sbjct: 213 VATTGQILNIPDAYAHPL---------FYRGVDDSTGFRTRNILCFPIKNENQEVIGVAE 263
Query: 89 IINKTDG 95
++NK +G
Sbjct: 264 LVNKING 270
>AY495087-1|AAS75513.1| 932|Homo sapiens cGMP-stimulated
phosphodiesterase 4 protein.
Length = 932
Score = 303 bits (744), Expect = 2e-81
Identities = 163/442 (36%), Positives = 252/442 (57%), Gaps = 16/442 (3%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRT--LLCMPIVNANKDVIGVAQLIN 344
IA VA + + LNI D + ++S G RT +LC PI N N++VIGVA+L+N
Sbjct: 456 IAGHVATTGQILNIPDA--YAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVN 513
Query: 345 K-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDT 399
K F++ D + AF+I+CG+ I ++ +Y+ + + +A E + YH S ++
Sbjct: 514 KINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEY 573
Query: 400 SKLCQDEIP--SAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
+KL D I +A N SF + L ++DT A L M + + I L R+
Sbjct: 574 TKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARF 633
Query: 458 ILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRG 517
L VKK YR YHNW HA + + + + K ++ ++ D+EI L ++C+CHDLDHRG
Sbjct: 634 CLMVKKGYRDPPYHNWMHAFSASHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRG 693
Query: 518 TNNAFQTKTESPLAILYST--STMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
TNN+FQ ++S LA LYS+ S ME HHF Q + ILN+ NIF S +DY+ ++ ++
Sbjct: 694 TNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMR 753
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHR 635
IL+TDLA + + ++ + G +D ++ LL ++MT+CD+S K W+ +
Sbjct: 754 DIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRK 812
Query: 636 IAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFP 695
IA+L+ EFF QGDLEK + +P+ MMDREK +P++Q+ F++ I +P+YK+L D FP
Sbjct: 813 IAELIYKEFFSQGDLEK-AMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFP 870
Query: 696 WMTPLRTGTADNRRRWQDLAEK 717
L A NR W ++ K
Sbjct: 871 KAAELYERVASNREHWTKVSHK 892
Score = 44.4 bits (100), Expect = 0.002
Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 9/67 (13%)
Query: 29 ISTSGMHTPIPGKIPHKLTAIKYITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQ 88
++T+G IP H L F +D TG++T ILC PI N +V+GVA+
Sbjct: 460 VATTGQILNIPDAYAHPL---------FYRGVDDSTGFRTRNILCFPIKNENQEVIGVAE 510
Query: 89 IINKTDG 95
++NK +G
Sbjct: 511 LVNKING 517
Score = 41.5 bits (93), Expect = 0.012
Identities = 22/79 (27%), Positives = 40/79 (50%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+ D V + + + + F+ Q LL +A+++F ++ L+ +I
Sbjct: 349 FTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEI 408
Query: 210 MTEARDLLKCERCAVFILD 228
+TEAR+L E C+VF+LD
Sbjct: 409 ITEARNLSNAEICSVFLLD 427
>BC040974-1|AAH40974.1| 941|Homo sapiens phosphodiesterase 2A,
cGMP-stimulated protein.
Length = 941
Score = 302 bits (741), Expect = 4e-81
Identities = 163/442 (36%), Positives = 252/442 (57%), Gaps = 16/442 (3%)
Query: 287 IALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRT--LLCMPIVNANKDVIGVAQLIN 344
IA VA + + LNI D + ++S G RT +LC PI N N++VIGVA+L+N
Sbjct: 465 IAGHVATTGQILNIPDA--YAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVN 522
Query: 345 K-----FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDT 399
K F++ D + AF+I+CG+ I ++ +Y+ + + +A E + YH S ++
Sbjct: 523 KINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEY 582
Query: 400 SKLCQDEIP--SAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
+KL D I +A N SF + L ++DT A L M + + I L R+
Sbjct: 583 TKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARF 642
Query: 458 ILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRG 517
L VKK YR YHNW HA +V+ + + K ++ ++ D+EI L ++C+CHDLDHRG
Sbjct: 643 CLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRG 702
Query: 518 TNNAFQTKTESPLAILYST--STMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
TNN+FQ ++S LA LYS+ S ME HHF Q + ILN+ NIF S +DY+ ++ ++
Sbjct: 703 TNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMR 762
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHR 635
IL+TDLA + + ++ + G +D ++ LL ++MT+CD+S K W+ +
Sbjct: 763 DIILATDLAHHLRIFKDLQKMAEVG-YDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRK 821
Query: 636 IAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFP 695
IA+L+ EFF QGDLEK + +P+ MMDREK +P++Q+ F++ I +P+YK+L D FP
Sbjct: 822 IAELIYKEFFSQGDLEK-AMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQDLFP 879
Query: 696 WMTPLRTGTADNRRRWQDLAEK 717
L A N W ++ K
Sbjct: 880 KAAELYERVASNGEHWTKVSHK 901
Score = 44.4 bits (100), Expect = 0.002
Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 9/67 (13%)
Query: 29 ISTSGMHTPIPGKIPHKLTAIKYITIQFNSEIDARTGYKTELILCMPICNYEGDVVGVAQ 88
++T+G IP H L F +D TG++T ILC PI N +V+GVA+
Sbjct: 469 VATTGQILNIPDAYAHPL---------FYRGVDDSTGFRTRNILCFPIKNENQEVIGVAE 519
Query: 89 IINKTDG 95
++NK +G
Sbjct: 520 LVNKING 526
Score = 41.5 bits (93), Expect = 0.012
Identities = 22/79 (27%), Positives = 40/79 (50%)
Query: 150 FSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKI 209
F+ D V + + + + F+ Q LL +A+++F ++ L+ +I
Sbjct: 358 FTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEI 417
Query: 210 MTEARDLLKCERCAVFILD 228
+TEAR+L E C+VF+LD
Sbjct: 418 ITEARNLSNAEICSVFLLD 436
>BT007016-1|AAP35662.1| 533|Homo sapiens phosphodiesterase 9A
protein.
Length = 533
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 218 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 277
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 278 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 337
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 338 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 395
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 396 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 452
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 453 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 497
>BC009047-1|AAH09047.1| 533|Homo sapiens phosphodiesterase 9A
protein.
Length = 533
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 218 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 277
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 278 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 337
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 338 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 395
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 396 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 452
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 453 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 497
>AY701187-1|AAV84271.1| 485|Homo sapiens phosphodiesterase PDE9A21
protein.
Length = 485
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 170 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 229
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 230 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 289
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 290 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 347
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 348 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 404
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 405 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 449
>AY242121-1|AAO88210.1| 492|Homo sapiens type 9 cGMP-specific
phosphodiesterase isoform 5 protein.
Length = 492
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 177 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 236
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 237 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 296
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 297 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 354
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 355 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 411
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 412 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 456
>AY196314-1|AAO34700.1| 386|Homo sapiens phosphodiesterase PDE9A20
protein.
Length = 386
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 130
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 131 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 190
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 191 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 248
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 249 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 305
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 306 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 350
>AY196313-1|AAO34699.1| 386|Homo sapiens phosphodiesterase PDE9A19
protein.
Length = 386
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 130
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 131 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 190
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 191 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 248
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 249 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 305
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 306 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 350
>AY196312-1|AAO34698.1| 567|Homo sapiens phosphodiesterase PDE9A18
protein.
Length = 567
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 252 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 311
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 312 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 371
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 372 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 429
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 430 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 486
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 487 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 531
>AY196311-1|AAO34697.1| 552|Homo sapiens phosphodiesterase PDE9A17
protein.
Length = 552
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 237 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 296
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 297 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 356
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 357 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 414
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 415 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 471
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 472 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 516
>AY196310-1|AAO34696.1| 526|Homo sapiens phosphodiesterase PDE9A16
protein.
Length = 526
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 211 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 270
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 271 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 330
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 331 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 388
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 389 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 445
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 446 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 490
>AY196309-1|AAO34695.1| 376|Homo sapiens phosphodiesterase PDE9A15
protein.
Length = 376
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 61 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 120
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 121 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 180
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 181 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 238
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 239 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 295
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 296 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 340
>AY196308-1|AAO34694.1| 386|Homo sapiens phosphodiesterase PDE9A14
protein.
Length = 386
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 130
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 131 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 190
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 191 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 248
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 249 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 305
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 306 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 350
>AY196307-1|AAO34693.1| 491|Homo sapiens phosphodiesterase PDE9A13
protein.
Length = 491
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 176 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 235
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 236 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 295
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 296 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 353
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 354 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 410
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 411 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 455
>AY196306-1|AAO34692.1| 459|Homo sapiens phosphodiesterase PDE9A12
protein.
Length = 459
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 144 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 203
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 204 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 263
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 264 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 321
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 322 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 378
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 379 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 423
>AY196305-1|AAO34691.1| 376|Homo sapiens phosphodiesterase PDE9A11
protein.
Length = 376
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 61 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 120
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 121 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 180
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 181 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 238
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 239 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 295
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 296 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 340
>AY196304-1|AAO34690.1| 433|Homo sapiens phosphodiesterase PDE9A10
protein.
Length = 433
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 118 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 177
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 178 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 237
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 238 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 295
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 296 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 352
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 353 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 397
>AY196303-1|AAO34689.1| 507|Homo sapiens phosphodiesterase PDE9A9
protein.
Length = 507
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 192 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 251
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 252 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 311
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 312 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 369
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 370 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 426
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 427 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 471
>AY196302-1|AAO34688.1| 386|Homo sapiens phosphodiesterase PDE9A8
protein.
Length = 386
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 130
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 131 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 190
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 191 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 248
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 249 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 305
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 306 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 350
>AY196301-1|AAO34687.1| 386|Homo sapiens phosphodiesterase PDE9A7
protein.
Length = 386
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 130
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 131 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 190
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 191 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 248
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 249 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 305
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 306 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 350
>AY196300-1|AAO34686.1| 492|Homo sapiens phosphodiesterase PDE9A6
protein.
Length = 492
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 177 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 236
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 237 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 296
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 297 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 354
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 355 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 411
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 412 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 456
>AY196299-1|AAO34685.1| 540|Homo sapiens phosphodiesterase PDE9A5
protein.
Length = 540
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 225 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 284
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 285 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 344
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 345 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 402
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 403 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 459
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 460 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 504
>AP001747-1|BAA95552.1| 593|Homo sapiens CGMP-specific 3',5'-cyclic
phosphodiesterase type 9, EC 3.1.4.17. protein.
Length = 593
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 278 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 337
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 338 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 397
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 398 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 455
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 456 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 512
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 513 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 557
>AF067226-1|AAC26726.1| 465|Homo sapiens cGMP phosphodiesterase A4
protein.
Length = 465
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 150 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 209
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 210 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 269
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 270 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 327
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 328 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 384
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 385 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 429
>AF067225-1|AAC26725.1| 466|Homo sapiens cGMP phosphodiesterase A3
protein.
Length = 466
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 151 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 210
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 211 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 270
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 271 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 328
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 329 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 385
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 386 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 430
>AF067224-1|AAC26724.1| 533|Homo sapiens cGMP phosphodiesterase A2
protein.
Length = 533
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 218 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 277
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 278 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 337
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 338 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 395
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 396 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 452
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 453 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 497
>AF067223-1|AAC26723.1| 593|Homo sapiens cGMP phosphodiesterase A1
protein.
Length = 593
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 278 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 337
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 338 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 397
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 398 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 455
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 456 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 512
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 513 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 557
>AF048837-1|AAC39778.1| 593|Homo sapiens cGMP-specific
phosphodiesterase protein.
Length = 593
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 278 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 337
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 338 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 397
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 398 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 455
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 456 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 512
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 513 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 557
>AB017602-1|BAA88847.1| 593|Homo sapiens cGMP phosphodiesterase
protein.
Length = 593
Score = 157 bits (382), Expect = 1e-37
Identities = 93/286 (32%), Positives = 153/286 (53%), Gaps = 9/286 (3%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFM 496
M+ LV F I L RW+ V NYR +HN+RH VAQ M++M+ ++
Sbjct: 278 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKF 337
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
S +IL L+ A +CHDLDH G NN +Q + LA+ Y+ S +E+HH IL
Sbjct: 338 SQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPE 397
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCG 615
NIF + P +K + + T IL+TD+A + + F E ++N FD+ +E LL
Sbjct: 398 CNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKM 455
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIA-MMDREKKDELPQM 674
+++ CD+S +P EV + +E+F Q D EK + P+A MDR+K +
Sbjct: 456 ILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE--GLPVAPFMDRDKVTK-ATA 512
Query: 675 QVGFIDTICLPLYKVLSDTFPWMTPLRTGTA-DNRRRWQDLAEKVD 719
Q+GFI + +P+++ ++ FP + + ++R R+++L +++D
Sbjct: 513 QIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEEL-KRID 557
>U40370-1|AAC50436.1| 535|Homo sapiens 3',5' cyclic nucleotide
phosphodiesterase protein.
Length = 535
Score = 139 bits (337), Expect = 3e-32
Identities = 87/262 (33%), Positives = 149/262 (56%), Gaps = 14/262 (5%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKME 493
+F + +L+ +F IP L + +++ Y K YHN HA +V QT+ + ML TG M
Sbjct: 183 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 242
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
++++LEIL ++ A HD +H GT N F +T S +AILY+ S +E+HH ++
Sbjct: 243 -WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 301
Query: 553 SESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKEL 612
E NI LS D++D+ ++V +LSTD++ +F++ ++ + N + ++ +
Sbjct: 302 EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQ----IKNIRNSLQQPEGIDRAKT 357
Query: 613 LCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDEL 671
+ +++ A D+S AK W++ +R + +EFF QGD E +L L P+ DR K +
Sbjct: 358 M-SLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC--DR-KSTMV 413
Query: 672 PQMQVGFIDTICLPLYKVLSDT 693
Q Q+GFID I P + +L+D+
Sbjct: 414 AQSQIGFIDFIVEPTFSLLTDS 435
>BC022480-1|AAH22480.1| 545|Homo sapiens phosphodiesterase 1A,
calmodulin-dependent protein.
Length = 545
Score = 139 bits (337), Expect = 3e-32
Identities = 87/262 (33%), Positives = 149/262 (56%), Gaps = 14/262 (5%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKME 493
+F + +L+ +F IP L + +++ Y K YHN HA +V QT+ + ML TG M
Sbjct: 183 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 242
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
++++LEIL ++ A HD +H GT N F +T S +AILY+ S +E+HH ++
Sbjct: 243 -WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 301
Query: 553 SESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKEL 612
E NI LS D++D+ ++V +LSTD++ +F++ ++ + N + ++ +
Sbjct: 302 EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQ----IKNIRNSLQQPEGIDRAKT 357
Query: 613 LCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDEL 671
+ +++ A D+S AK W++ +R + +EFF QGD E +L L P+ DR K +
Sbjct: 358 M-SLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC--DR-KSTMV 413
Query: 672 PQMQVGFIDTICLPLYKVLSDT 693
Q Q+GFID I P + +L+D+
Sbjct: 414 AQSQIGFIDFIVEPTFSLLTDS 435
>AL110263-1|CAB53703.1| 519|Homo sapiens hypothetical protein
protein.
Length = 519
Score = 139 bits (337), Expect = 3e-32
Identities = 87/262 (33%), Positives = 149/262 (56%), Gaps = 14/262 (5%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKME 493
+F + +L+ +F IP L + +++ Y K YHN HA +V QT+ + ML TG M
Sbjct: 167 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 226
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
++++LEIL ++ A HD +H GT N F +T S +AILY+ S +E+HH ++
Sbjct: 227 -WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 285
Query: 553 SESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKEL 612
E NI LS D++D+ ++V +LSTD++ +F++ ++ + N + ++ +
Sbjct: 286 EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQ----IKNIRNSLQQPEGIDRAKT 341
Query: 613 LCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDEL 671
+ +++ A D+S AK W++ +R + +EFF QGD E +L L P+ DR K +
Sbjct: 342 M-SLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC--DR-KSTMV 397
Query: 672 PQMQVGFIDTICLPLYKVLSDT 693
Q Q+GFID I P + +L+D+
Sbjct: 398 AQSQIGFIDFIVEPTFSLLTDS 419
>AJ401610-1|CAC82208.1| 519|Homo sapiens 3'5' cyclic nucleotide
phosphodiesterase 1A5 protein.
Length = 519
Score = 139 bits (337), Expect = 3e-32
Identities = 87/262 (33%), Positives = 149/262 (56%), Gaps = 14/262 (5%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKME 493
+F + +L+ +F IP L + +++ Y K YHN HA +V QT+ + ML TG M
Sbjct: 167 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 226
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
++++LEIL ++ A HD +H GT N F +T S +AILY+ S +E+HH ++
Sbjct: 227 -WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 285
Query: 553 SESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKEL 612
E NI LS D++D+ ++V +LSTD++ +F++ ++ + N + ++ +
Sbjct: 286 EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQ----IKNIRNSLQQPEGIDRAKT 341
Query: 613 LCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDEL 671
+ +++ A D+S AK W++ +R + +EFF QGD E +L L P+ DR K +
Sbjct: 342 M-SLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC--DR-KSTMV 397
Query: 672 PQMQVGFIDTICLPLYKVLSDT 693
Q Q+GFID I P + +L+D+
Sbjct: 398 AQSQIGFIDFIVEPTFSLLTDS 419
>AB038224-9|BAB20054.1| 518|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 518
Score = 139 bits (337), Expect = 3e-32
Identities = 87/262 (33%), Positives = 149/262 (56%), Gaps = 14/262 (5%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKME 493
+F + +L+ +F IP L + +++ Y K YHN HA +V QT+ + ML TG M
Sbjct: 149 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 208
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
++++LEIL ++ A HD +H GT N F +T S +AILY+ S +E+HH ++
Sbjct: 209 -WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 267
Query: 553 SESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKEL 612
E NI LS D++D+ ++V +LSTD++ +F++ ++ + N + ++ +
Sbjct: 268 EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQ----IKNIRNSLQQPEGIDRAKT 323
Query: 613 LCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDEL 671
+ +++ A D+S AK W++ +R + +EFF QGD E +L L P+ DR K +
Sbjct: 324 M-SLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC--DR-KSTMV 379
Query: 672 PQMQVGFIDTICLPLYKVLSDT 693
Q Q+GFID I P + +L+D+
Sbjct: 380 AQSQIGFIDFIVEPTFSLLTDS 401
>AB038224-8|BAB20053.1| 501|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 501
Score = 139 bits (337), Expect = 3e-32
Identities = 87/262 (33%), Positives = 149/262 (56%), Gaps = 14/262 (5%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKME 493
+F + +L+ +F IP L + +++ Y K YHN HA +V QT+ + ML TG M
Sbjct: 149 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 208
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
++++LEIL ++ A HD +H GT N F +T S +AILY+ S +E+HH ++
Sbjct: 209 -WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 267
Query: 553 SESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKEL 612
E NI LS D++D+ ++V +LSTD++ +F++ ++ + N + ++ +
Sbjct: 268 EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQ----IKNIRNSLQQPEGIDRAKT 323
Query: 613 LCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDEL 671
+ +++ A D+S AK W++ +R + +EFF QGD E +L L P+ DR K +
Sbjct: 324 M-SLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC--DR-KSTMV 379
Query: 672 PQMQVGFIDTICLPLYKVLSDT 693
Q Q+GFID I P + +L+D+
Sbjct: 380 AQSQIGFIDFIVEPTFSLLTDS 401
>AB038224-7|BAB20057.1| 511|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 511
Score = 139 bits (337), Expect = 3e-32
Identities = 87/262 (33%), Positives = 149/262 (56%), Gaps = 14/262 (5%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKME 493
+F + +L+ +F IP L + +++ Y K YHN HA +V QT+ + ML TG M
Sbjct: 149 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 208
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
++++LEIL ++ A HD +H GT N F +T S +AILY+ S +E+HH ++
Sbjct: 209 -WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 267
Query: 553 SESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKEL 612
E NI LS D++D+ ++V +LSTD++ +F++ ++ + N + ++ +
Sbjct: 268 EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQ----IKNIRNSLQQPEGIDRAKT 323
Query: 613 LCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDEL 671
+ +++ A D+S AK W++ +R + +EFF QGD E +L L P+ DR K +
Sbjct: 324 M-SLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC--DR-KSTMV 379
Query: 672 PQMQVGFIDTICLPLYKVLSDT 693
Q Q+GFID I P + +L+D+
Sbjct: 380 AQSQIGFIDFIVEPTFSLLTDS 401
>AB038224-6|BAB20052.1| 552|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 552
Score = 139 bits (337), Expect = 3e-32
Identities = 87/262 (33%), Positives = 149/262 (56%), Gaps = 14/262 (5%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKME 493
+F + +L+ +F IP L + +++ Y K YHN HA +V QT+ + ML TG M
Sbjct: 183 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 242
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
++++LEIL ++ A HD +H GT N F +T S +AILY+ S +E+HH ++
Sbjct: 243 -WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 301
Query: 553 SESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKEL 612
E NI LS D++D+ ++V +LSTD++ +F++ ++ + N + ++ +
Sbjct: 302 EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQ----IKNIRNSLQQPEGIDRAKT 357
Query: 613 LCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDEL 671
+ +++ A D+S AK W++ +R + +EFF QGD E +L L P+ DR K +
Sbjct: 358 M-SLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC--DR-KSTMV 413
Query: 672 PQMQVGFIDTICLPLYKVLSDT 693
Q Q+GFID I P + +L+D+
Sbjct: 414 AQSQIGFIDFIVEPTFSLLTDS 435
>AB038224-5|BAB20050.1| 535|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 535
Score = 139 bits (337), Expect = 3e-32
Identities = 87/262 (33%), Positives = 149/262 (56%), Gaps = 14/262 (5%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKME 493
+F + +L+ +F IP L + +++ Y K YHN HA +V QT+ + ML TG M
Sbjct: 183 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 242
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
++++LEIL ++ A HD +H GT N F +T S +AILY+ S +E+HH ++
Sbjct: 243 -WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 301
Query: 553 SESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKEL 612
E NI LS D++D+ ++V +LSTD++ +F++ ++ + N + ++ +
Sbjct: 302 EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQ----IKNIRNSLQQPEGIDRAKT 357
Query: 613 LCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDEL 671
+ +++ A D+S AK W++ +R + +EFF QGD E +L L P+ DR K +
Sbjct: 358 M-SLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC--DR-KSTMV 413
Query: 672 PQMQVGFIDTICLPLYKVLSDT 693
Q Q+GFID I P + +L+D+
Sbjct: 414 AQSQIGFIDFIVEPTFSLLTDS 435
>AB038224-4|BAB20056.1| 545|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 545
Score = 139 bits (337), Expect = 3e-32
Identities = 87/262 (33%), Positives = 149/262 (56%), Gaps = 14/262 (5%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKME 493
+F + +L+ +F IP L + +++ Y K YHN HA +V QT+ + ML TG M
Sbjct: 183 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 242
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
++++LEIL ++ A HD +H GT N F +T S +AILY+ S +E+HH ++
Sbjct: 243 -WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 301
Query: 553 SESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKEL 612
E NI LS D++D+ ++V +LSTD++ +F++ ++ + N + ++ +
Sbjct: 302 EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQ----IKNIRNSLQQPEGIDRAKT 357
Query: 613 LCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDEL 671
+ +++ A D+S AK W++ +R + +EFF QGD E +L L P+ DR K +
Sbjct: 358 M-SLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC--DR-KSTMV 413
Query: 672 PQMQVGFIDTICLPLYKVLSDT 693
Q Q+GFID I P + +L+D+
Sbjct: 414 AQSQIGFIDFIVEPTFSLLTDS 435
>AB038224-3|BAB20051.1| 536|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 536
Score = 139 bits (337), Expect = 3e-32
Identities = 87/262 (33%), Positives = 149/262 (56%), Gaps = 14/262 (5%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKME 493
+F + +L+ +F IP L + +++ Y K YHN HA +V QT+ + ML TG M
Sbjct: 167 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 226
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
++++LEIL ++ A HD +H GT N F +T S +AILY+ S +E+HH ++
Sbjct: 227 -WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 285
Query: 553 SESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKEL 612
E NI LS D++D+ ++V +LSTD++ +F++ ++ + N + ++ +
Sbjct: 286 EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQ----IKNIRNSLQQPEGIDRAKT 341
Query: 613 LCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDEL 671
+ +++ A D+S AK W++ +R + +EFF QGD E +L L P+ DR K +
Sbjct: 342 M-SLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC--DR-KSTMV 397
Query: 672 PQMQVGFIDTICLPLYKVLSDT 693
Q Q+GFID I P + +L+D+
Sbjct: 398 AQSQIGFIDFIVEPTFSLLTDS 419
>AB038224-2|BAB20049.1| 519|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 519
Score = 139 bits (337), Expect = 3e-32
Identities = 87/262 (33%), Positives = 149/262 (56%), Gaps = 14/262 (5%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKME 493
+F + +L+ +F IP L + +++ Y K YHN HA +V QT+ + ML TG M
Sbjct: 167 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 226
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
++++LEIL ++ A HD +H GT N F +T S +AILY+ S +E+HH ++
Sbjct: 227 -WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 285
Query: 553 SESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKEL 612
E NI LS D++D+ ++V +LSTD++ +F++ ++ + N + ++ +
Sbjct: 286 EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQ----IKNIRNSLQQPEGIDRAKT 341
Query: 613 LCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDEL 671
+ +++ A D+S AK W++ +R + +EFF QGD E +L L P+ DR K +
Sbjct: 342 M-SLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC--DR-KSTMV 397
Query: 672 PQMQVGFIDTICLPLYKVLSDT 693
Q Q+GFID I P + +L+D+
Sbjct: 398 AQSQIGFIDFIVEPTFSLLTDS 419
>AB038224-1|BAB20055.1| 529|Homo sapiens calmodulin-dependent
phosphodiesterase protein.
Length = 529
Score = 139 bits (337), Expect = 3e-32
Identities = 87/262 (33%), Positives = 149/262 (56%), Gaps = 14/262 (5%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTM-FAMLKTGKME 493
+F + +L+ +F IP L + +++ Y K YHN HA +V QT+ + ML TG M
Sbjct: 167 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 226
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
++++LEIL ++ A HD +H GT N F +T S +AILY+ S +E+HH ++
Sbjct: 227 -WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ 285
Query: 553 SESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKEL 612
E NI LS D++D+ ++V +LSTD++ +F++ ++ + N + ++ +
Sbjct: 286 EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQ----IKNIRNSLQQPEGIDRAKT 341
Query: 613 LCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDEL 671
+ +++ A D+S AK W++ +R + +EFF QGD E +L L P+ DR K +
Sbjct: 342 M-SLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLC--DR-KSTMV 397
Query: 672 PQMQVGFIDTICLPLYKVLSDT 693
Q Q+GFID I P + +L+D+
Sbjct: 398 AQSQIGFIDFIVEPTFSLLTDS 419
>U40372-1|AAA96961.1| 564|Homo sapiens PDE1C3 protein.
Length = 564
Score = 134 bits (324), Expect = 1e-30
Identities = 90/257 (35%), Positives = 141/257 (54%), Gaps = 15/257 (5%)
Query: 442 ELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTMFAML-KTGKMERFMSD 498
+L+ +F IP L ++ +++ Y K YHN HA +V QT+ +L KTG + ++++
Sbjct: 52 DLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTG-VANWLTE 110
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMIL-NSESN 556
LEI ++ + HD +H GT N F +T S AILY+ S +E+HH +L + E
Sbjct: 111 LEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEM 170
Query: 557 NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGM 616
NI LS D+++ +V +++TD++ +F++ + E A EK + L M
Sbjct: 171 NILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE----AIEKPKALSLM 226
Query: 617 MMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDELPQMQ 675
+ TA D+S AK W++ HR + +EFF QGD E +L L P+ DR K + Q Q
Sbjct: 227 LHTA-DISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLC--DR-KSTMVAQSQ 282
Query: 676 VGFIDTICLPLYKVLSD 692
VGFID I P + VL+D
Sbjct: 283 VGFIDFIVEPTFTVLTD 299
>U40371-1|AAC50437.1| 634|Homo sapiens 3',5' cyclic nucleotide
phosphodiesterase protein.
Length = 634
Score = 134 bits (324), Expect = 1e-30
Identities = 90/257 (35%), Positives = 141/257 (54%), Gaps = 15/257 (5%)
Query: 442 ELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTMFAML-KTGKMERFMSD 498
+L+ +F IP L ++ +++ Y K YHN HA +V QT+ +L KTG + ++++
Sbjct: 197 DLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTG-VANWLTE 255
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMIL-NSESN 556
LEI ++ + HD +H GT N F +T S AILY+ S +E+HH +L + E
Sbjct: 256 LEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEM 315
Query: 557 NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGM 616
NI LS D+++ +V +++TD++ +F++ + E A EK + L M
Sbjct: 316 NILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE----AIEKPKALSLM 371
Query: 617 MMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDELPQMQ 675
+ TA D+S AK W++ HR + +EFF QGD E +L L P+ DR K + Q Q
Sbjct: 372 LHTA-DISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLC--DR-KSTMVAQSQ 427
Query: 676 VGFIDTICLPLYKVLSD 692
VGFID I P + VL+D
Sbjct: 428 VGFIDFIVEPTFTVLTD 444
>BC022525-1|AAH22525.1| 634|Homo sapiens PDE1C protein protein.
Length = 634
Score = 134 bits (324), Expect = 1e-30
Identities = 90/257 (35%), Positives = 141/257 (54%), Gaps = 15/257 (5%)
Query: 442 ELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTMFAML-KTGKMERFMSD 498
+L+ +F IP L ++ +++ Y K YHN HA +V QT+ +L KTG + ++++
Sbjct: 197 DLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTG-VANWLTE 255
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMIL-NSESN 556
LEI ++ + HD +H GT N F +T S AILY+ S +E+HH +L + E
Sbjct: 256 LEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEM 315
Query: 557 NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGM 616
NI LS D+++ +V +++TD++ +F++ + E A EK + L M
Sbjct: 316 NILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE----AIEKPKALSLM 371
Query: 617 MMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDELPQMQ 675
+ TA D+S AK W++ HR + +EFF QGD E +L L P+ DR K + Q Q
Sbjct: 372 LHTA-DISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLC--DR-KSTMVAQSQ 427
Query: 676 VGFIDTICLPLYKVLSD 692
VGFID I P + VL+D
Sbjct: 428 VGFIDFIVEPTFTVLTD 444
>BC022479-1|AAH22479.1| 634|Homo sapiens PDE1C protein protein.
Length = 634
Score = 134 bits (324), Expect = 1e-30
Identities = 90/257 (35%), Positives = 141/257 (54%), Gaps = 15/257 (5%)
Query: 442 ELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTMFAML-KTGKMERFMSD 498
+L+ +F IP L ++ +++ Y K YHN HA +V QT+ +L KTG + ++++
Sbjct: 197 DLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTG-VANWLTE 255
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMIL-NSESN 556
LEI ++ + HD +H GT N F +T S AILY+ S +E+HH +L + E
Sbjct: 256 LEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEM 315
Query: 557 NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGM 616
NI LS D+++ +V +++TD++ +F++ + E A EK + L M
Sbjct: 316 NILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE----AIEKPKALSLM 371
Query: 617 MMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDELPQMQ 675
+ TA D+S AK W++ HR + +EFF QGD E +L L P+ DR K + Q Q
Sbjct: 372 LHTA-DISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLC--DR-KSTMVAQSQ 427
Query: 676 VGFIDTICLPLYKVLSD 692
VGFID I P + VL+D
Sbjct: 428 VGFIDFIVEPTFTVLTD 444
>AK091734-1|BAC03734.1| 769|Homo sapiens (EC 3.1.4.17). protein.
Length = 769
Score = 134 bits (324), Expect = 1e-30
Identities = 90/257 (35%), Positives = 141/257 (54%), Gaps = 15/257 (5%)
Query: 442 ELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTMFAML-KTGKMERFMSD 498
+L+ +F IP L ++ +++ Y K YHN HA +V QT+ +L KTG + ++++
Sbjct: 257 DLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTG-VANWLTE 315
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMIL-NSESN 556
LEI ++ + HD +H GT N F +T S AILY+ S +E+HH +L + E
Sbjct: 316 LEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEM 375
Query: 557 NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGM 616
NI LS D+++ +V +++TD++ +F++ + E A EK + L M
Sbjct: 376 NILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE----AIEKPKALSLM 431
Query: 617 MMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDELPQMQ 675
+ TA D+S AK W++ HR + +EFF QGD E +L L P+ DR K + Q Q
Sbjct: 432 LHTA-DISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLC--DR-KSTMVAQSQ 487
Query: 676 VGFIDTICLPLYKVLSD 692
VGFID I P + VL+D
Sbjct: 488 VGFIDFIVEPTFTVLTD 504
>AC006377-1|AAS07516.1| 591|Homo sapiens unknown protein.
Length = 591
Score = 134 bits (324), Expect = 1e-30
Identities = 90/257 (35%), Positives = 141/257 (54%), Gaps = 15/257 (5%)
Query: 442 ELVEKFHIPYDVLCRWILSVKKNYRPVK--YHNWRHALNVAQTMFAML-KTGKMERFMSD 498
+L+ +F IP L ++ +++ Y K YHN HA +V QT+ +L KTG + ++++
Sbjct: 154 DLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTG-VANWLTE 212
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMIL-NSESN 556
LEI ++ + HD +H GT N F +T S AILY+ S +E+HH +L + E
Sbjct: 213 LEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEM 272
Query: 557 NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGM 616
NI LS D+++ +V +++TD++ +F++ + E A EK + L M
Sbjct: 273 NILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE----AIEKPKALSLM 328
Query: 617 MMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMMDREKKDELPQMQ 675
+ TA D+S AK W++ HR + +EFF QGD E +L L P+ DR K + Q Q
Sbjct: 329 LHTA-DISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLC--DR-KSTMVAQSQ 384
Query: 676 VGFIDTICLPLYKVLSD 692
VGFID I P + VL+D
Sbjct: 385 VGFIDFIVEPTFTVLTD 401
>U97584-1|AAC25679.1| 647|Homo sapiens cyclic AMP-specific
phosphodiesterase HSPDE4A1A protein.
Length = 647
Score = 132 bits (319), Expect = 5e-30
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 13/323 (4%)
Query: 398 DTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
D +L E+ + + L F D+ TC + +F + +L++KF IP D + +
Sbjct: 121 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTY 179
Query: 458 ILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+L+++ +Y V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH
Sbjct: 180 MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHP 239
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
G +N F T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V
Sbjct: 240 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVI 299
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAK 628
+L+TD++ + + +V+ + ++ ++L M+ A D+S K
Sbjct: 300 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 358
Query: 629 PWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
P E+ + + EFF QGD E+ + + M D+ + + QVGFID I PL++
Sbjct: 359 PLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLWE 416
Query: 689 VLSDTFPWMTPLRTGTADNRRRW 711
+D T ++ R W
Sbjct: 417 TWADLVHPDAQEILDTLEDNRDW 439
>U68532-1|AAC63832.1| 647|Homo sapiens cyclic AMP specific
phosphodiesterase RD1 protein.
Length = 647
Score = 132 bits (319), Expect = 5e-30
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 13/323 (4%)
Query: 398 DTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
D +L E+ + + L F D+ TC + +F + +L++KF IP D + +
Sbjct: 121 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTY 179
Query: 458 ILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+L+++ +Y V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH
Sbjct: 180 MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHP 239
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
G +N F T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V
Sbjct: 240 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVI 299
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAK 628
+L+TD++ + + +V+ + ++ ++L M+ A D+S K
Sbjct: 300 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 358
Query: 629 PWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
P E+ + + EFF QGD E+ + + M D+ + + QVGFID I PL++
Sbjct: 359 PLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLWE 416
Query: 689 VLSDTFPWMTPLRTGTADNRRRW 711
+D T ++ R W
Sbjct: 417 TWADLVHPDAQEILDTLEDNRDW 439
>U18087-1|AAC50458.1| 686|Homo sapiens 3',5'-cyclic AMP
phosphodiesterase HPDE4A6 protein.
Length = 686
Score = 132 bits (319), Expect = 5e-30
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 13/323 (4%)
Query: 398 DTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
D +L E+ + + L F D+ TC + +F + +L++KF IP D + +
Sbjct: 160 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTY 218
Query: 458 ILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+L+++ +Y V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH
Sbjct: 219 MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHP 278
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
G +N F T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V
Sbjct: 279 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVI 338
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAK 628
+L+TD++ + + +V+ + ++ ++L M+ A D+S K
Sbjct: 339 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 397
Query: 629 PWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
P E+ + + EFF QGD E+ + + M D+ + + QVGFID I PL++
Sbjct: 398 PLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLWE 455
Query: 689 VLSDTFPWMTPLRTGTADNRRRW 711
+D T ++ R W
Sbjct: 456 TWADLVHPDAQEILDTLEDNRDW 478
>S75213-1|AAB33798.1| 667|Homo sapiens type-IVA cyclic AMP specific
phosphodiesterase protein.
Length = 667
Score = 132 bits (319), Expect = 5e-30
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 13/323 (4%)
Query: 398 DTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
D +L E+ + + L F D+ TC + +F + +L++KF IP D + +
Sbjct: 141 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTY 199
Query: 458 ILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+L+++ +Y V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH
Sbjct: 200 MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHP 259
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
G +N F T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V
Sbjct: 260 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVI 319
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAK 628
+L+TD++ + + +V+ + ++ ++L M+ A D+S K
Sbjct: 320 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 378
Query: 629 PWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
P E+ + + EFF QGD E+ + + M D+ + + QVGFID I PL++
Sbjct: 379 PLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLWE 436
Query: 689 VLSDTFPWMTPLRTGTADNRRRW 711
+D T ++ R W
Sbjct: 437 TWADLVHPDAQEILDTLEDNRDW 459
>M37744-1|AAA69697.1| 775|Homo sapiens protein ( Human cyclic AMP
(cAMP)-specific phosphodiesterase mRNA, complete cds. ).
Length = 775
Score = 132 bits (319), Expect = 5e-30
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 13/323 (4%)
Query: 398 DTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
D +L E+ + + L F D+ TC + +F + +L++KF IP D + +
Sbjct: 249 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTY 307
Query: 458 ILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+L+++ +Y V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH
Sbjct: 308 MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHP 367
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
G +N F T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V
Sbjct: 368 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVI 427
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAK 628
+L+TD++ + + +V+ + ++ ++L M+ A D+S K
Sbjct: 428 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 486
Query: 629 PWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
P E+ + + EFF QGD E+ + + M D+ + + QVGFID I PL++
Sbjct: 487 PLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLWE 544
Query: 689 VLSDTFPWMTPLRTGTADNRRRW 711
+D T ++ R W
Sbjct: 545 TWADLVHPDAQEILDTLEDNRDW 567
>L20965-1|AAA03588.1| 886|Homo sapiens phosphodiesterase protein.
Length = 886
Score = 132 bits (319), Expect = 5e-30
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 13/323 (4%)
Query: 398 DTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
D +L E+ + + L F D+ TC + +F + +L++KF IP D + +
Sbjct: 360 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTY 418
Query: 458 ILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+L+++ +Y V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH
Sbjct: 419 MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHP 478
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
G +N F T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V
Sbjct: 479 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVI 538
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAK 628
+L+TD++ + + +V+ + ++ ++L M+ A D+S K
Sbjct: 539 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 597
Query: 629 PWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
P E+ + + EFF QGD E+ + + M D+ + + QVGFID I PL++
Sbjct: 598 PLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLWE 655
Query: 689 VLSDTFPWMTPLRTGTADNRRRW 711
+D T ++ R W
Sbjct: 656 TWADLVHPDAQEILDTLEDNRDW 678
>BC038234-1|AAH38234.1| 647|Homo sapiens phosphodiesterase 4A,
cAMP-specific (phosphodiesterase E2 dunce homolog,
Drosop protein.
Length = 647
Score = 132 bits (319), Expect = 5e-30
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 13/323 (4%)
Query: 398 DTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
D +L E+ + + L F D+ TC + +F + +L++KF IP D + +
Sbjct: 121 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTY 179
Query: 458 ILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+L+++ +Y V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH
Sbjct: 180 MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHP 239
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
G +N F T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V
Sbjct: 240 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVI 299
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAK 628
+L+TD++ + + +V+ + ++ ++L M+ A D+S K
Sbjct: 300 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 358
Query: 629 PWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
P E+ + + EFF QGD E+ + + M D+ + + QVGFID I PL++
Sbjct: 359 PLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLWE 416
Query: 689 VLSDTFPWMTPLRTGTADNRRRW 711
+D T ++ R W
Sbjct: 417 TWADLVHPDAQEILDTLEDNRDW 439
>BC019864-1|AAH19864.1| 647|Homo sapiens phosphodiesterase 4A,
cAMP-specific (phosphodiesterase E2 dunce homolog,
Drosop protein.
Length = 647
Score = 132 bits (319), Expect = 5e-30
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 13/323 (4%)
Query: 398 DTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
D +L E+ + + L F D+ TC + +F + +L++KF IP D + +
Sbjct: 121 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTY 179
Query: 458 ILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+L+++ +Y V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH
Sbjct: 180 MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHP 239
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
G +N F T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V
Sbjct: 240 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVI 299
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAK 628
+L+TD++ + + +V+ + ++ ++L M+ A D+S K
Sbjct: 300 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 358
Query: 629 PWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
P E+ + + EFF QGD E+ + + M D+ + + QVGFID I PL++
Sbjct: 359 PLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLWE 416
Query: 689 VLSDTFPWMTPLRTGTADNRRRW 711
+D T ++ R W
Sbjct: 417 TWADLVHPDAQEILDTLEDNRDW 439
>AY618547-1|AAU82096.1| 860|Homo sapiens cyclic AMP
phosphodiesterase PDE4A11 protein.
Length = 860
Score = 132 bits (319), Expect = 5e-30
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 13/323 (4%)
Query: 398 DTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
D +L E+ + + L F D+ TC + +F + +L++KF IP D + +
Sbjct: 334 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTY 392
Query: 458 ILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+L+++ +Y V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH
Sbjct: 393 MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHP 452
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
G +N F T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V
Sbjct: 453 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVI 512
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAK 628
+L+TD++ + + +V+ + ++ ++L M+ A D+S K
Sbjct: 513 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 571
Query: 629 PWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
P E+ + + EFF QGD E+ + + M D+ + + QVGFID I PL++
Sbjct: 572 PLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLWE 629
Query: 689 VLSDTFPWMTPLRTGTADNRRRW 711
+D T ++ R W
Sbjct: 630 TWADLVHPDAQEILDTLEDNRDW 652
>AY593872-1|AAT00628.1| 864|Homo sapiens cAMP-specific
phosphodiesterase protein.
Length = 864
Score = 132 bits (319), Expect = 5e-30
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 13/323 (4%)
Query: 398 DTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
D +L E+ + + L F D+ TC + +F + +L++KF IP D + +
Sbjct: 338 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTY 396
Query: 458 ILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+L+++ +Y V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH
Sbjct: 397 MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHP 456
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
G +N F T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V
Sbjct: 457 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVI 516
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAK 628
+L+TD++ + + +V+ + ++ ++L M+ A D+S K
Sbjct: 517 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 575
Query: 629 PWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
P E+ + + EFF QGD E+ + + M D+ + + QVGFID I PL++
Sbjct: 576 PLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLWE 633
Query: 689 VLSDTFPWMTPLRTGTADNRRRW 711
+D T ++ R W
Sbjct: 634 TWADLVHPDAQEILDTLEDNRDW 656
>AF073745-1|AAD34217.2| 825|Homo sapiens cyclic AMP-specific
phosphodiesterase HSPDE4A10 protein.
Length = 825
Score = 132 bits (319), Expect = 5e-30
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 13/323 (4%)
Query: 398 DTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
D +L E+ + + L F D+ TC + +F + +L++KF IP D + +
Sbjct: 299 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTY 357
Query: 458 ILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+L+++ +Y V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH
Sbjct: 358 MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHP 417
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
G +N F T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V
Sbjct: 418 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVI 477
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAK 628
+L+TD++ + + +V+ + ++ ++L M+ A D+S K
Sbjct: 478 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 536
Query: 629 PWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
P E+ + + EFF QGD E+ + + M D+ + + QVGFID I PL++
Sbjct: 537 PLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLWE 594
Query: 689 VLSDTFPWMTPLRTGTADNRRRW 711
+D T ++ R W
Sbjct: 595 TWADLVHPDAQEILDTLEDNRDW 617
>AF069491-3|AAC35013.1| 647|Homo sapiens cAMP specific
phosphodiesterase 4A variant RD1 protein.
Length = 647
Score = 132 bits (319), Expect = 5e-30
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 13/323 (4%)
Query: 398 DTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
D +L E+ + + L F D+ TC + +F + +L++KF IP D + +
Sbjct: 121 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTY 179
Query: 458 ILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+L+++ +Y V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH
Sbjct: 180 MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHP 239
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
G +N F T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V
Sbjct: 240 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVI 299
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAK 628
+L+TD++ + + +V+ + ++ ++L M+ A D+S K
Sbjct: 300 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 358
Query: 629 PWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
P E+ + + EFF QGD E+ + + M D+ + + QVGFID I PL++
Sbjct: 359 PLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLWE 416
Query: 689 VLSDTFPWMTPLRTGTADNRRRW 711
+D T ++ R W
Sbjct: 417 TWADLVHPDAQEILDTLEDNRDW 439
>AF069491-2|AAC35015.1| 860|Homo sapiens putative novel cAMP
specific phosphodiesterase 4A variant protein.
Length = 860
Score = 132 bits (319), Expect = 5e-30
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 13/323 (4%)
Query: 398 DTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
D +L E+ + + L F D+ TC + +F + +L++KF IP D + +
Sbjct: 334 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTY 392
Query: 458 ILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+L+++ +Y V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH
Sbjct: 393 MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHP 452
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
G +N F T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V
Sbjct: 453 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVI 512
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAK 628
+L+TD++ + + +V+ + ++ ++L M+ A D+S K
Sbjct: 513 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 571
Query: 629 PWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
P E+ + + EFF QGD E+ + + M D+ + + QVGFID I PL++
Sbjct: 572 PLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLWE 629
Query: 689 VLSDTFPWMTPLRTGTADNRRRW 711
+D T ++ R W
Sbjct: 630 TWADLVHPDAQEILDTLEDNRDW 652
>AF069491-1|AAC35012.1| 886|Homo sapiens cAMP specific
phosphodiesterase 4A variant pde46 protein.
Length = 886
Score = 132 bits (319), Expect = 5e-30
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 13/323 (4%)
Query: 398 DTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRW 457
D +L E+ + + L F D+ TC + +F + +L++KF IP D + +
Sbjct: 360 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTY 418
Query: 458 ILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+L+++ +Y V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH
Sbjct: 419 MLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHP 478
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVE 575
G +N F T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V
Sbjct: 479 GVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVI 538
Query: 576 TAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAK 628
+L+TD++ + + +V+ + ++ ++L M+ A D+S K
Sbjct: 539 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 597
Query: 629 PWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
P E+ + + EFF QGD E+ + + M D+ + + QVGFID I PL++
Sbjct: 598 PLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLWE 655
Query: 689 VLSDTFPWMTPLRTGTADNRRRW 711
+D T ++ R W
Sbjct: 656 TWADLVHPDAQEILDTLEDNRDW 678
>U88713-1|AAC51916.1| 700|Homo sapiens phosphodiesterase 4C
protein.
Length = 700
Score = 128 bits (310), Expect = 6e-29
Identities = 94/312 (30%), Positives = 151/312 (48%), Gaps = 13/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 341 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 400
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E
Sbjct: 401 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 460
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 461 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 520
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 521 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 578
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 579 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 637
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 638 RDGPDRFQFELT 649
>U88712-1|AAC51915.1| 606|Homo sapiens phosphodiesterase 4C
protein.
Length = 606
Score = 128 bits (310), Expect = 6e-29
Identities = 94/312 (30%), Positives = 151/312 (48%), Gaps = 13/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 247 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 306
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E
Sbjct: 307 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 366
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 367 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 426
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 427 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 484
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 485 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 543
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 544 RDGPDRFQFELT 555
>U66348-1|AAB96877.1| 518|Homo sapiens PDE4C-delta54 protein.
Length = 518
Score = 128 bits (310), Expect = 6e-29
Identities = 94/312 (30%), Positives = 151/312 (48%), Gaps = 13/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 159 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 218
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E
Sbjct: 219 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 278
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 279 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 338
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 339 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 396
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 397 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 455
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 456 RDGPDRFQFELT 467
>U66347-1|AAB96876.1| 426|Homo sapiens PDE4C-426 protein.
Length = 426
Score = 128 bits (310), Expect = 6e-29
Identities = 94/312 (30%), Positives = 151/312 (48%), Gaps = 13/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 67 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 126
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E
Sbjct: 127 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 186
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 187 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 246
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 247 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 304
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 305 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 363
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 364 RDGPDRFQFELT 375
>U66346-1|AAB96875.1| 791|Homo sapiens PDE4C-791 protein.
Length = 791
Score = 128 bits (310), Expect = 6e-29
Identities = 94/312 (30%), Positives = 151/312 (48%), Gaps = 13/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 432 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 491
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E
Sbjct: 492 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 551
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 552 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 611
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 612 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 669
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 670 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 728
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 729 RDGPDRFQFELT 740
>BC109068-1|AAI09069.1| 549|Homo sapiens PDE4C protein protein.
Length = 549
Score = 128 bits (310), Expect = 6e-29
Identities = 94/312 (30%), Positives = 151/312 (48%), Gaps = 13/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 190 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 249
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E
Sbjct: 250 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 309
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 310 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 369
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 370 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 427
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 428 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 486
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 487 RDGPDRFQFELT 498
>BC109067-1|AAI09068.1| 481|Homo sapiens PDE4C protein protein.
Length = 481
Score = 128 bits (310), Expect = 6e-29
Identities = 94/312 (30%), Positives = 151/312 (48%), Gaps = 13/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 122 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 181
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E
Sbjct: 182 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 241
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 242 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 301
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 302 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 359
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 360 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 418
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 419 RDGPDRFQFELT 430
>AF157816-3|AAD47055.1| 606|Homo sapiens cAMP specific
phosphodiesterase PDE4C2 variant protein.
Length = 606
Score = 128 bits (310), Expect = 6e-29
Identities = 94/312 (30%), Positives = 151/312 (48%), Gaps = 13/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 247 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 306
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E
Sbjct: 307 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 366
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 367 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 426
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 427 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 484
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 485 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 543
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 544 RDGPDRFQFELT 555
>AF157816-2|AAD47054.1| 680|Homo sapiens cAMP specific
phosphodiesterase PDE4C3 variant protein.
Length = 680
Score = 128 bits (310), Expect = 6e-29
Identities = 94/312 (30%), Positives = 151/312 (48%), Gaps = 13/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 321 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 380
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E
Sbjct: 381 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 440
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 441 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 500
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 501 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 558
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 559 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 617
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 618 RDGPDRFQFELT 629
>AF157816-1|AAD47053.1| 712|Homo sapiens cAMP specific
phosphodiesterase PDE4C1 variant protein.
Length = 712
Score = 128 bits (310), Expect = 6e-29
Identities = 94/312 (30%), Positives = 151/312 (48%), Gaps = 13/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 353 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 412
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E
Sbjct: 413 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 472
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 473 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 532
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 533 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 590
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 591 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 649
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 650 RDGPDRFQFELT 661
>AC005759-5|AAC83049.1| 426|Homo sapiens PDE4C-426 protein.
Length = 426
Score = 128 bits (310), Expect = 6e-29
Identities = 94/312 (30%), Positives = 151/312 (48%), Gaps = 13/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 67 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 126
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E
Sbjct: 127 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 186
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 187 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 246
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 247 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 304
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 305 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 363
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 364 RDGPDRFQFELT 375
>AC005759-3|AAC83051.1| 518|Homo sapiens PDE4C-delta54 protein.
Length = 518
Score = 128 bits (310), Expect = 6e-29
Identities = 94/312 (30%), Positives = 151/312 (48%), Gaps = 13/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 159 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 218
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E
Sbjct: 219 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 278
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 279 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 338
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 339 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 396
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 397 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 455
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 456 RDGPDRFQFELT 467
>AC005759-1|AAC83050.1| 782|Homo sapiens PDE4C-791 protein.
Length = 782
Score = 128 bits (310), Expect = 6e-29
Identities = 94/312 (30%), Positives = 151/312 (48%), Gaps = 13/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 423 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 482
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E
Sbjct: 483 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 542
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 543 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 602
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 603 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 660
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 661 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 719
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 720 RDGPDRFQFELT 731
>U86078-1|AAC51872.1| 536|Homo sapiens calmodulin-stimulated
phosphodiesterase PDE1B1 protein.
Length = 536
Score = 128 bits (308), Expect = 1e-28
Identities = 84/285 (29%), Positives = 145/285 (50%), Gaps = 14/285 (4%)
Query: 414 NLYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-- 469
+L+ F + +D T+ + + L+ +F IP L ++ +++ Y K
Sbjct: 162 DLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNP 221
Query: 470 YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESP 529
YHN HA +V QT+ L M +S++E+L ++ A HD +H GT N+F +T+S
Sbjct: 222 YHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSE 281
Query: 530 LAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFK 588
AI+Y+ S +E+HH ++ + NIF L+ ++ ++ +V +L+TD++ +F+
Sbjct: 282 CAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQ 341
Query: 589 KKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQG 648
+ + E + + K L +++ A D+S K W V R K + +EFF QG
Sbjct: 342 QVKTMKTALQQLE---RIDKPKAL--SLLLHAADISHPTKQWLVHSRWTKALMEEFFRQG 396
Query: 649 DLE-KLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSD 692
D E +L L P+ DR + Q Q+GFID I P + VL+D
Sbjct: 397 DKEAELGLPFSPLC--DR-TSTLVAQSQIGFIDFIVEPTFSVLTD 438
>U56976-1|AAC50769.1| 536|Homo sapiens calmodulin dependent
phosphodiesterase PDE1B1 protein.
Length = 536
Score = 128 bits (308), Expect = 1e-28
Identities = 84/285 (29%), Positives = 145/285 (50%), Gaps = 14/285 (4%)
Query: 414 NLYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-- 469
+L+ F + +D T+ + + L+ +F IP L ++ +++ Y K
Sbjct: 162 DLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNP 221
Query: 470 YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESP 529
YHN HA +V QT+ L M +S++E+L ++ A HD +H GT N+F +T+S
Sbjct: 222 YHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSE 281
Query: 530 LAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFK 588
AI+Y+ S +E+HH ++ + NIF L+ ++ ++ +V +L+TD++ +F+
Sbjct: 282 CAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQ 341
Query: 589 KKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQG 648
+ + E + + K L +++ A D+S K W V R K + +EFF QG
Sbjct: 342 QVKTMKTALQQLE---RIDKPKAL--SLLLHAADISHPTKQWLVHSRWTKALMEEFFRQG 396
Query: 649 DLE-KLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSD 692
D E +L L P+ DR + Q Q+GFID I P + VL+D
Sbjct: 397 DKEAELGLPFSPLC--DR-TSTLVAQSQIGFIDFIVEPTFSVLTD 438
>BX538092-1|CAD98011.1| 399|Homo sapiens hypothetical protein
protein.
Length = 399
Score = 128 bits (308), Expect = 1e-28
Identities = 84/285 (29%), Positives = 145/285 (50%), Gaps = 14/285 (4%)
Query: 414 NLYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-- 469
+L+ F + +D T+ + + L+ +F IP L ++ +++ Y K
Sbjct: 25 DLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNP 84
Query: 470 YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESP 529
YHN HA +V QT+ L M +S++E+L ++ A HD +H GT N+F +T+S
Sbjct: 85 YHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSE 144
Query: 530 LAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFK 588
AI+Y+ S +E+HH ++ + NIF L+ ++ ++ +V +L+TD++ +F+
Sbjct: 145 CAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQ 204
Query: 589 KKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQG 648
+ + E + + K L +++ A D+S K W V R K + +EFF QG
Sbjct: 205 QVKTMKTALQQLE---RIDKPKAL--SLLLHAADISHPTKQWLVHSRWTKALMEEFFRQG 259
Query: 649 DLE-KLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSD 692
D E +L L P+ DR + Q Q+GFID I P + VL+D
Sbjct: 260 DKEAELGLPFSPLC--DR-TSTLVAQSQIGFIDFIVEPTFSVLTD 301
>BC032226-1|AAH32226.1| 536|Homo sapiens phosphodiesterase 1B,
calmodulin-dependent protein.
Length = 536
Score = 128 bits (308), Expect = 1e-28
Identities = 84/285 (29%), Positives = 145/285 (50%), Gaps = 14/285 (4%)
Query: 414 NLYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-- 469
+L+ F + +D T+ + + L+ +F IP L ++ +++ Y K
Sbjct: 162 DLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNP 221
Query: 470 YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESP 529
YHN HA +V QT+ L M +S++E+L ++ A HD +H GT N+F +T+S
Sbjct: 222 YHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSE 281
Query: 530 LAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFK 588
AI+Y+ S +E+HH ++ + NIF L+ ++ ++ +V +L+TD++ +F+
Sbjct: 282 CAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQ 341
Query: 589 KKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQG 648
+ + E + + K L +++ A D+S K W V R K + +EFF QG
Sbjct: 342 QVKTMKTALQQLE---RIDKPKAL--SLLLHAADISHPTKQWLVHSRWTKALMEEFFRQG 396
Query: 649 DLE-KLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSD 692
D E +L L P+ DR + Q Q+GFID I P + VL+D
Sbjct: 397 DKEAELGLPFSPLC--DR-TSTLVAQSQIGFIDFIVEPTFSVLTD 438
>AJ401609-1|CAC82207.1| 516|Homo sapiens 3'5' cyclic nucleotide
phosphodiesterase 1B2 protein.
Length = 516
Score = 128 bits (308), Expect = 1e-28
Identities = 84/285 (29%), Positives = 145/285 (50%), Gaps = 14/285 (4%)
Query: 414 NLYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-- 469
+L+ F + +D T+ + + L+ +F IP L ++ +++ Y K
Sbjct: 142 DLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNP 201
Query: 470 YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESP 529
YHN HA +V QT+ L M +S++E+L ++ A HD +H GT N+F +T+S
Sbjct: 202 YHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSE 261
Query: 530 LAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFK 588
AI+Y+ S +E+HH ++ + NIF L+ ++ ++ +V +L+TD++ +F+
Sbjct: 262 CAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQ 321
Query: 589 KKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQG 648
+ + E + + K L +++ A D+S K W V R K + +EFF QG
Sbjct: 322 QVKTMKTALQQLE---RIDKPKAL--SLLLHAADISHPTKQWLVHSRWTKALMEEFFRQG 376
Query: 649 DLE-KLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSD 692
D E +L L P+ DR + Q Q+GFID I P + VL+D
Sbjct: 377 DKEAELGLPFSPLC--DR-TSTLVAQSQIGFIDFIVEPTFSVLTD 418
>Z46632-1|CAA86601.1| 712|Homo sapiens 3',5'-cyclic AMP
phosphodiesterase protein.
Length = 712
Score = 127 bits (307), Expect = 1e-28
Identities = 93/312 (29%), Positives = 151/312 (48%), Gaps = 13/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 353 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 412
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T S +A++Y+ S +E+HH +L +E
Sbjct: 413 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSDVALMYNDASVLENHHLAVGFKLLQAE 472
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 473 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 532
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 533 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 590
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 591 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 649
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 650 RDGPDRFQFELT 661
>U02882-1|AAC13745.1| 604|Homo sapiens 3',5'-cyclic AMP
phosphodiesterase protein.
Length = 604
Score = 127 bits (307), Expect = 1e-28
Identities = 83/286 (29%), Positives = 148/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 222 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 281
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ +S +E+HH +L E
Sbjct: 282 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 341
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ +IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 342 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 401
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 402 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFPQGDRER-ERGMEISPMCDKHN 459
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 460 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 504
>U50159-1|AAA97892.1| 673|Homo sapiens cAMP-specific
phoshodiesterase HPDE4D3 variant protein.
Length = 673
Score = 127 bits (306), Expect = 2e-28
Identities = 83/286 (29%), Positives = 148/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 291 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 350
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ +S +E+HH +L E
Sbjct: 351 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 410
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ +IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 411 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 470
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 471 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFRQGDRER-ERGMEISPMCDKHN 528
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 529 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 573
>U50158-1|AAA97891.1| 507|Homo sapiens cAMP-specific
phosphodiesterase HPDE4D2 variant protein.
Length = 507
Score = 127 bits (306), Expect = 2e-28
Identities = 83/286 (29%), Positives = 148/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 125 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 184
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ +S +E+HH +L E
Sbjct: 185 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 244
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ +IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 245 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 304
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 305 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFRQGDRER-ERGMEISPMCDKHN 362
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 363 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 407
>U50157-1|AAA97890.1| 585|Homo sapiens cAMP-specific
phosphodiesterase HPDE4D1 variant protein.
Length = 585
Score = 127 bits (306), Expect = 2e-28
Identities = 83/286 (29%), Positives = 148/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 203 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 262
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ +S +E+HH +L E
Sbjct: 263 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 322
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ +IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 323 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 382
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 383 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFRQGDRER-ERGMEISPMCDKHN 440
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 441 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 485
>L20970-1|AAA03592.1| 673|Homo sapiens phosphodiesterase protein.
Length = 673
Score = 127 bits (306), Expect = 2e-28
Identities = 83/286 (29%), Positives = 148/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 291 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 350
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ +S +E+HH +L E
Sbjct: 351 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 410
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ +IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 411 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 470
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 471 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFRQGDRER-ERGMEISPMCDKHN 528
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 529 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 573
>L20969-1|AAC00042.1| 809|Homo sapiens cyclic AMP phosphodiesterase
protein.
Length = 809
Score = 127 bits (306), Expect = 2e-28
Identities = 83/286 (29%), Positives = 148/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 427 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 486
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ +S +E+HH +L E
Sbjct: 487 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 546
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ +IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 547 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 606
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 607 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFRQGDRER-ERGMEISPMCDKHN 664
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 665 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 709
>AY388960-1|AAQ90404.1| 679|Homo sapiens cAMP-specific
phosphodiesterase PDE4D9 protein.
Length = 679
Score = 127 bits (306), Expect = 2e-28
Identities = 83/286 (29%), Positives = 148/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 297 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 356
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ +S +E+HH +L E
Sbjct: 357 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 416
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ +IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 417 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 476
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 477 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFRQGDRER-ERGMEISPMCDKHN 534
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 535 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 579
>AY245867-1|AAP75761.1| 679|Homo sapiens cAMP-specific
phosphodiesterase variant PDE4D9 protein.
Length = 679
Score = 127 bits (306), Expect = 2e-28
Identities = 83/286 (29%), Positives = 148/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 297 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 356
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ +S +E+HH +L E
Sbjct: 357 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 416
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ +IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 417 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 476
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 477 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFRQGDRER-ERGMEISPMCDKHN 534
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 535 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 579
>AY245866-1|AAP75760.1| 748|Homo sapiens cAMP-specific
phosphodiesterase variant PDE4D7 protein.
Length = 748
Score = 127 bits (306), Expect = 2e-28
Identities = 83/286 (29%), Positives = 148/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 366 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 425
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ +S +E+HH +L E
Sbjct: 426 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 485
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ +IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 486 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 545
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 546 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFRQGDRER-ERGMEISPMCDKHN 603
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 604 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 648
>AF536976-1|AAN10118.1| 748|Homo sapiens cAMP-specific
phosphodiesterase PDE4D7 protein.
Length = 748
Score = 127 bits (306), Expect = 2e-28
Identities = 83/286 (29%), Positives = 148/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 366 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 425
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ +S +E+HH +L E
Sbjct: 426 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 485
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ +IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 486 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 545
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 546 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFRQGDRER-ERGMEISPMCDKHN 603
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 604 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 648
>AF536975-1|AAN10117.1| 518|Homo sapiens cAMP-specific
phosphodiesterase PDE4D6 protein.
Length = 518
Score = 127 bits (306), Expect = 2e-28
Identities = 83/286 (29%), Positives = 148/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 136 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 195
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ +S +E+HH +L E
Sbjct: 196 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 255
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ +IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 256 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 315
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 316 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFRQGDRER-ERGMEISPMCDKHN 373
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 374 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 418
>AF012074-1|AAC00070.1| 507|Homo sapiens cAMP-specific
phosphodiesterase PDE4D2 protein.
Length = 507
Score = 127 bits (306), Expect = 2e-28
Identities = 83/286 (29%), Positives = 148/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 125 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 184
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ +S +E+HH +L E
Sbjct: 185 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 244
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ +IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 245 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 304
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 305 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFRQGDRER-ERGMEISPMCDKHN 362
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 363 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 407
>AF012073-1|AAC00069.1| 745|Homo sapiens cAMP-specific
phosphodiesterase PDE4D5 protein.
Length = 745
Score = 127 bits (306), Expect = 2e-28
Identities = 83/286 (29%), Positives = 148/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 363 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 422
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ +S +E+HH +L E
Sbjct: 423 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 482
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ +IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 483 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 542
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 543 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFRQGDRER-ERGMEISPMCDKHN 600
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 601 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 645
>AF536977-1|AAN10119.1| 687|Homo sapiens cAMP-specific
phosphodiesterase PDE4D8 protein.
Length = 687
Score = 126 bits (305), Expect = 3e-28
Identities = 83/286 (29%), Positives = 147/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 305 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 364
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ +S +E+HH +L E
Sbjct: 365 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 424
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 425 NCGIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 484
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 485 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFRQGDRER-ERGMEISPMCDKHN 542
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 543 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 587
>U67932-1|AAB65772.1| 456|Homo sapiens cAMP phosphodiesterase PDE7
protein.
Length = 456
Score = 125 bits (302), Expect = 6e-28
Identities = 92/324 (28%), Positives = 157/324 (48%), Gaps = 14/324 (4%)
Query: 373 NACKLMAKQKVALECLSYHATASAEDTSKLCQDEIPSA----ETYNLYSFQFHDFD-LTD 427
N +L++ Q+ + TA + + L D A E ++F FD LT+
Sbjct: 81 NIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTN 140
Query: 428 EDTCRA-TLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFA 485
++ + T +F L+E FH+ L R+++ ++++Y YHN HA +V Q M
Sbjct: 141 GNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHC 200
Query: 486 MLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY-STSTMEHHHF 544
LK K+ ++ +IL L+A HDLDH G N F KT LA LY +TS +E+HH+
Sbjct: 201 YLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHW 260
Query: 545 DQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDW 604
V +L + +F L + + + IL+TD++ + S F +D G+
Sbjct: 261 RSAVGLL--RESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCL 318
Query: 605 QAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMM 663
+ + L+ M + D+ + WE+ + ++ V +EFF QGD+E K L P+
Sbjct: 319 EDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLC-- 376
Query: 664 DREKKDELPQMQVGFIDTICLPLY 687
DR + + +Q+GF+ + PL+
Sbjct: 377 DRH-TESIANIQIGFMTYLVEPLF 399
>L12052-1|AAA35644.2| 482|Homo sapiens cAMP phosphodiesterase PDE7
protein.
Length = 482
Score = 125 bits (302), Expect = 6e-28
Identities = 92/324 (28%), Positives = 157/324 (48%), Gaps = 14/324 (4%)
Query: 373 NACKLMAKQKVALECLSYHATASAEDTSKLCQDEIPSA----ETYNLYSFQFHDFD-LTD 427
N +L++ Q+ + TA + + L D A E ++F FD LT+
Sbjct: 107 NIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTN 166
Query: 428 EDTCRA-TLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFA 485
++ + T +F L+E FH+ L R+++ ++++Y YHN HA +V Q M
Sbjct: 167 GNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHC 226
Query: 486 MLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY-STSTMEHHHF 544
LK K+ ++ +IL L+A HDLDH G N F KT LA LY +TS +E+HH+
Sbjct: 227 YLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHW 286
Query: 545 DQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDW 604
V +L + +F L + + + IL+TD++ + S F +D G+
Sbjct: 287 RSAVGLL--RESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCL 344
Query: 605 QAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMM 663
+ + L+ M + D+ + WE+ + ++ V +EFF QGD+E K L P+
Sbjct: 345 EDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLC-- 402
Query: 664 DREKKDELPQMQVGFIDTICLPLY 687
DR + + +Q+GF+ + PL+
Sbjct: 403 DRH-TESIANIQIGFMTYLVEPLF 425
>BC126360-1|AAI26361.1| 456|Homo sapiens phosphodiesterase 7A
protein.
Length = 456
Score = 125 bits (302), Expect = 6e-28
Identities = 92/324 (28%), Positives = 157/324 (48%), Gaps = 14/324 (4%)
Query: 373 NACKLMAKQKVALECLSYHATASAEDTSKLCQDEIPSA----ETYNLYSFQFHDFD-LTD 427
N +L++ Q+ + TA + + L D A E ++F FD LT+
Sbjct: 81 NIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTN 140
Query: 428 EDTCRA-TLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFA 485
++ + T +F L+E FH+ L R+++ ++++Y YHN HA +V Q M
Sbjct: 141 GNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHC 200
Query: 486 MLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY-STSTMEHHHF 544
LK K+ ++ +IL L+A HDLDH G N F KT LA LY +TS +E+HH+
Sbjct: 201 YLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHW 260
Query: 545 DQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDW 604
V +L + +F L + + + IL+TD++ + S F +D G+
Sbjct: 261 RSAVGLL--RESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCL 318
Query: 605 QAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMM 663
+ + L+ M + D+ + WE+ + ++ V +EFF QGD+E K L P+
Sbjct: 319 EDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLC-- 376
Query: 664 DREKKDELPQMQVGFIDTICLPLY 687
DR + + +Q+GF+ + PL+
Sbjct: 377 DRH-TESIANIQIGFMTYLVEPLF 399
>BC036319-1|AAH36319.1| 518|Homo sapiens PDE4D protein protein.
Length = 518
Score = 125 bits (302), Expect = 6e-28
Identities = 83/286 (29%), Positives = 147/286 (51%), Gaps = 13/286 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++++++ +Y V YHN HA +V Q+ +L T +E
Sbjct: 136 IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV 195
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G N F T S LA++Y+ +S +E+HH +L E
Sbjct: 196 FTDLEILAAIFASAIHDVDHPGVFNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE 255
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+ +IFQ L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 256 NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS 315
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S KP ++ + + +EFF QGD E+ + + M D+
Sbjct: 316 DRIQVLQNMVHCA-DLSNPTKPLQLYRQWTDRIMEEFFRQGDRER-ERGMEISPMCDKHN 373
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQ 712
+ + QVGFID I PL++ +D P + DNR +Q
Sbjct: 374 A-SVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQ 418
>AC005759-2|AAC83047.1| 710|Homo sapiens CN4C_HUMAN protein.
Length = 710
Score = 122 bits (295), Expect = 4e-27
Identities = 93/312 (29%), Positives = 151/312 (48%), Gaps = 15/312 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F IP D L ++L ++ +Y V YHN HA +VAQ+ +L T +E
Sbjct: 353 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 412
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL L A HD+DH G +N F T+ LA++Y+ S +E+HH +L +E
Sbjct: 413 FTDLEILAALFASAIHDVDHPGVSNQFLINTK--LALMYNDASVLENHHLAVGFKLLQAE 470
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQE 608
+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 471 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 530
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREK 667
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 531 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHT 588
Query: 668 KDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWID 726
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 589 A-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPE 647
Query: 727 HDTIDKPVEEFT 738
D D+ E T
Sbjct: 648 RDGPDRFQFELT 659
>AF332652-1|AAK57640.1| 424|Homo sapiens cAMP-specific cyclic
nucleotide phosphodiesterase PDE7A3 protein.
Length = 424
Score = 119 bits (286), Expect = 5e-26
Identities = 89/314 (28%), Positives = 151/314 (48%), Gaps = 14/314 (4%)
Query: 373 NACKLMAKQKVALECLSYHATASAEDTSKLCQDEIPSA----ETYNLYSFQFHDFD-LTD 427
N +L++ Q+ + TA + + L D A E ++F FD LT+
Sbjct: 107 NIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTN 166
Query: 428 EDTCRA-TLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFA 485
++ + T +F L+E FH+ L R+++ ++++Y YHN HA +V Q M
Sbjct: 167 GNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHC 226
Query: 486 MLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY-STSTMEHHHF 544
LK K+ ++ +IL L+A HDLDH G N F KT LA LY +TS +E+HH+
Sbjct: 227 YLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHW 286
Query: 545 DQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDW 604
V +L + +F L + + + IL+TD++ + S F +D G+
Sbjct: 287 RSAVGLL--RESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCL 344
Query: 605 QAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLE-KLQLNQQPIAMM 663
+ + L+ M + D+ + WE+ + ++ V +EFF QGD+E K L P+
Sbjct: 345 EDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLC-- 402
Query: 664 DREKKDELPQMQVG 677
DR + + +Q+G
Sbjct: 403 DRH-TESIANIQIG 415
>U85048-1|AAB96381.1| 721|Homo sapiens cyclic AMP specific
phosphodiesterase protein.
Length = 721
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 356 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 415
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 416 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 475
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 476 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 535
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 536 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 593
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 594 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 640
>M97515-1|AAA36426.1| 564|Homo sapiens phosphodiesterase protein.
Length = 564
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 199 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 258
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 259 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 318
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 319 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 378
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 379 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 436
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 437 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 483
>L20971-1|AAA03593.1| 564|Homo sapiens phosphodiesterase protein.
Length = 564
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 199 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 258
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 259 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 318
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 319 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 378
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 379 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 436
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 437 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 483
>L20966-1|AAA03589.1| 736|Homo sapiens phosphodiesterase protein.
Length = 736
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 371 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 430
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 431 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 490
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 491 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 550
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 551 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 608
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 609 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 655
>L12686-1|AAA35643.1| 606|Homo sapiens 3',5'-cyclic AMP
phosphodiesterase protein.
Length = 606
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 241 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 300
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 301 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 360
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 361 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 420
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 421 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 478
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 479 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 525
>BC105040-1|AAI05041.1| 736|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 736
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 371 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 430
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 431 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 490
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 491 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 550
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 551 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 608
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 609 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 655
>BC101480-1|AAI01481.1| 736|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 736
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 371 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 430
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 431 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 490
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 491 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 550
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 551 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 608
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 609 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 655
>AL592285-3|CAH70628.1| 721|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 721
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 356 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 415
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 416 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 475
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 476 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 535
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 536 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 593
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 594 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 640
>AL592285-1|CAH70626.1| 736|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 736
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 371 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 430
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 431 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 490
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 491 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 550
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 551 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 608
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 609 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 655
>AL359701-3|CAI23101.1| 721|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 721
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 356 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 415
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 416 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 475
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 476 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 535
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 536 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 593
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 594 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 640
>AL359701-2|CAI23100.1| 564|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 564
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 199 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 258
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 259 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 318
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 319 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 378
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 379 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 436
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 437 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 483
>AL359701-1|CAI23099.1| 736|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 736
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 371 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 430
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 431 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 490
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 491 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 550
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 551 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 608
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 609 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 655
>AL357273-3|CAH73004.1| 721|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 721
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 356 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 415
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 416 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 475
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 476 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 535
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 536 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 593
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 594 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 640
>AL357273-1|CAH73002.1| 736|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 736
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 371 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 430
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 431 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 490
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 491 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 550
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 551 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 608
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 609 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 655
>AL109926-4|CAI21751.1| 721|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 721
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 356 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 415
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 416 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 475
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 476 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 535
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 536 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 593
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 594 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 640
>AL109926-3|CAI21750.1| 564|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 564
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 199 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 258
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 259 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 318
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 319 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 378
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 379 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 436
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 437 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 483
>AL109926-2|CAI21749.1| 736|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 736
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 371 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 430
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 431 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 490
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 491 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 550
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 551 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 608
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 609 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 655
>AB209081-1|BAD92318.1| 726|Homo sapiens phosphodiesterase 4B,
cAMP-specific (phosphodiesterase E4 dunce homolog,
Drosop protein.
Length = 726
Score = 118 bits (283), Expect = 1e-25
Identities = 80/288 (27%), Positives = 144/288 (50%), Gaps = 13/288 (4%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERF 495
+F + +L++ F I D ++++++ +Y V YHN HA +VAQ+ +L T ++
Sbjct: 361 IFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAV 420
Query: 496 MSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSE 554
+DLEIL + A HD+DH G +N F T S LA++Y+ S +E+HH +L E
Sbjct: 421 FTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEE 480
Query: 555 SNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQA-------Q 607
+IF L+ + + + +V +L+TD++ + + +V+ +
Sbjct: 481 HCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYT 540
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
++ ++L M+ A D+S K E+ + + +EFF QGD E+ + + M D+
Sbjct: 541 DRIQVLRNMVHCA-DLSNPTKSLELYRQWTDRIMEEFFQQGDKER-ERGMEISPMCDKHT 598
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTF-PWMTPLRTGTADNRRRWQDL 714
+ + QVGFID I PL++ +D P + DNR +Q +
Sbjct: 599 A-SVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM 645
>EF108327-1|ABL14249.1| 502|Homo sapiens phosphodiesterase PDE7B2
protein.
Length = 502
Score = 117 bits (282), Expect = 2e-25
Identities = 75/279 (26%), Positives = 138/279 (49%), Gaps = 10/279 (3%)
Query: 415 LYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YH 471
++ F FD TL +F L+ F + L R+++ V+++Y YH
Sbjct: 166 MWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYH 225
Query: 472 NWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLA 531
N HA +V Q M LK K+ F++ L+I+ L+A HD+DH G N F KT LA
Sbjct: 226 NAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLA 285
Query: 532 ILY-STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKK 590
LY + S +E+HH+ + +L + + L +D+ + + IL+TD+ +
Sbjct: 286 NLYQNMSVLENHHWRSTIGML--RESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFL 343
Query: 591 SKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDL 650
++ + N + + + + + + + D+ + WE+ + ++ V +EF+ QG+L
Sbjct: 344 TRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 403
Query: 651 E-KLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
E K +L P+ ++KD +P +Q+GF+ I PL++
Sbjct: 404 EQKFELEISPLC---NQQKDSIPSIQIGFMSYIVEPLFR 439
>BC075083-1|AAH75083.1| 450|Homo sapiens phosphodiesterase 7B
protein.
Length = 450
Score = 117 bits (282), Expect = 2e-25
Identities = 75/279 (26%), Positives = 138/279 (49%), Gaps = 10/279 (3%)
Query: 415 LYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YH 471
++ F FD TL +F L+ F + L R+++ V+++Y YH
Sbjct: 114 MWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYH 173
Query: 472 NWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLA 531
N HA +V Q M LK K+ F++ L+I+ L+A HD+DH G N F KT LA
Sbjct: 174 NAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLA 233
Query: 532 ILY-STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKK 590
LY + S +E+HH+ + +L + + L +D+ + + IL+TD+ +
Sbjct: 234 NLYQNMSVLENHHWRSTIGML--RESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFL 291
Query: 591 SKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDL 650
++ + N + + + + + + + D+ + WE+ + ++ V +EF+ QG+L
Sbjct: 292 TRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 351
Query: 651 E-KLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
E K +L P+ ++KD +P +Q+GF+ I PL++
Sbjct: 352 EQKFELEISPLC---NQQKDSIPSIQIGFMSYIVEPLFR 387
>BC075082-1|AAH75082.1| 450|Homo sapiens phosphodiesterase 7B
protein.
Length = 450
Score = 117 bits (282), Expect = 2e-25
Identities = 75/279 (26%), Positives = 138/279 (49%), Gaps = 10/279 (3%)
Query: 415 LYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YH 471
++ F FD TL +F L+ F + L R+++ V+++Y YH
Sbjct: 114 MWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYH 173
Query: 472 NWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLA 531
N HA +V Q M LK K+ F++ L+I+ L+A HD+DH G N F KT LA
Sbjct: 174 NAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLA 233
Query: 532 ILY-STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKK 590
LY + S +E+HH+ + +L + + L +D+ + + IL+TD+ +
Sbjct: 234 NLYQNMSVLENHHWRSTIGML--RESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFL 291
Query: 591 SKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDL 650
++ + N + + + + + + + D+ + WE+ + ++ V +EF+ QG+L
Sbjct: 292 TRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 351
Query: 651 E-KLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
E K +L P+ ++KD +P +Q+GF+ I PL++
Sbjct: 352 EQKFELEISPLC---NQQKDSIPSIQIGFMSYIVEPLFR 387
>AL360178-1|CAH73075.1| 450|Homo sapiens phosphodiesterase 7B
protein.
Length = 450
Score = 117 bits (282), Expect = 2e-25
Identities = 75/279 (26%), Positives = 138/279 (49%), Gaps = 10/279 (3%)
Query: 415 LYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YH 471
++ F FD TL +F L+ F + L R+++ V+++Y YH
Sbjct: 114 MWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYH 173
Query: 472 NWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLA 531
N HA +V Q M LK K+ F++ L+I+ L+A HD+DH G N F KT LA
Sbjct: 174 NAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLA 233
Query: 532 ILY-STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKK 590
LY + S +E+HH+ + +L + + L +D+ + + IL+TD+ +
Sbjct: 234 NLYQNMSVLENHHWRSTIGML--RESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFL 291
Query: 591 SKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDL 650
++ + N + + + + + + + D+ + WE+ + ++ V +EF+ QG+L
Sbjct: 292 TRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 351
Query: 651 E-KLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
E K +L P+ ++KD +P +Q+GF+ I PL++
Sbjct: 352 EQKFELEISPLC---NQQKDSIPSIQIGFMSYIVEPLFR 387
>AL138828-4|CAI95287.1| 450|Homo sapiens phosphodiesterase 7B
protein.
Length = 450
Score = 117 bits (282), Expect = 2e-25
Identities = 75/279 (26%), Positives = 138/279 (49%), Gaps = 10/279 (3%)
Query: 415 LYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YH 471
++ F FD TL +F L+ F + L R+++ V+++Y YH
Sbjct: 114 MWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYH 173
Query: 472 NWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLA 531
N HA +V Q M LK K+ F++ L+I+ L+A HD+DH G N F KT LA
Sbjct: 174 NAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLA 233
Query: 532 ILY-STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKK 590
LY + S +E+HH+ + +L + + L +D+ + + IL+TD+ +
Sbjct: 234 NLYQNMSVLENHHWRSTIGML--RESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFL 291
Query: 591 SKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDL 650
++ + N + + + + + + + D+ + WE+ + ++ V +EF+ QG+L
Sbjct: 292 TRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 351
Query: 651 E-KLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
E K +L P+ ++KD +P +Q+GF+ I PL++
Sbjct: 352 EQKFELEISPLC---NQQKDSIPSIQIGFMSYIVEPLFR 387
>AL133319-1|CAH73332.1| 450|Homo sapiens phosphodiesterase 7B
protein.
Length = 450
Score = 117 bits (282), Expect = 2e-25
Identities = 75/279 (26%), Positives = 138/279 (49%), Gaps = 10/279 (3%)
Query: 415 LYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YH 471
++ F FD TL +F L+ F + L R+++ V+++Y YH
Sbjct: 114 MWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYH 173
Query: 472 NWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLA 531
N HA +V Q M LK K+ F++ L+I+ L+A HD+DH G N F KT LA
Sbjct: 174 NAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLA 233
Query: 532 ILY-STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKK 590
LY + S +E+HH+ + +L + + L +D+ + + IL+TD+ +
Sbjct: 234 NLYQNMSVLENHHWRSTIGML--RESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFL 291
Query: 591 SKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDL 650
++ + N + + + + + + + D+ + WE+ + ++ V +EF+ QG+L
Sbjct: 292 TRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 351
Query: 651 E-KLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
E K +L P+ ++KD +P +Q+GF+ I PL++
Sbjct: 352 EQKFELEISPLC---NQQKDSIPSIQIGFMSYIVEPLFR 387
>AJ251860-1|CAB92441.1| 450|Homo sapiens phosphodiesterase 7B
protein.
Length = 450
Score = 117 bits (282), Expect = 2e-25
Identities = 75/279 (26%), Positives = 138/279 (49%), Gaps = 10/279 (3%)
Query: 415 LYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YH 471
++ F FD TL +F L+ F + L R+++ V+++Y YH
Sbjct: 114 MWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYH 173
Query: 472 NWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLA 531
N HA +V Q M LK K+ F++ L+I+ L+A HD+DH G N F KT LA
Sbjct: 174 NAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLA 233
Query: 532 ILY-STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKK 590
LY + S +E+HH+ + +L + + L +D+ + + IL+TD+ +
Sbjct: 234 NLYQNMSVLENHHWRSTIGML--RESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFL 291
Query: 591 SKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDL 650
++ + N + + + + + + + D+ + WE+ + ++ V +EF+ QG+L
Sbjct: 292 TRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 351
Query: 651 E-KLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
E K +L P+ ++KD +P +Q+GF+ I PL++
Sbjct: 352 EQKFELEISPLC---NQQKDSIPSIQIGFMSYIVEPLFR 387
>AC073834-2|AAX93113.1| 125|Homo sapiens unknown protein.
Length = 125
Score = 117 bits (282), Expect = 2e-25
Identities = 48/102 (47%), Positives = 73/102 (71%)
Query: 616 MMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQ 675
M+MTACD+ A+ KPWE+ ++A+LV EFF+QGD E+L+L P A+ DR +KDELP++Q
Sbjct: 2 MLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQ 61
Query: 676 VGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEK 717
+ +ID+IC+PLY+ L + P+ A NR +W++L +K
Sbjct: 62 LEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQK 103
>AB209990-1|BAE06072.1| 586|Homo sapiens PDE7B variant protein
protein.
Length = 586
Score = 117 bits (282), Expect = 2e-25
Identities = 75/279 (26%), Positives = 138/279 (49%), Gaps = 10/279 (3%)
Query: 415 LYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YH 471
++ F FD TL +F L+ F + L R+++ V+++Y YH
Sbjct: 250 MWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYH 309
Query: 472 NWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLA 531
N HA +V Q M LK K+ F++ L+I+ L+A HD+DH G N F KT LA
Sbjct: 310 NAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLA 369
Query: 532 ILY-STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKK 590
LY + S +E+HH+ + +L + + L +D+ + + IL+TD+ +
Sbjct: 370 NLYQNMSVLENHHWRSTIGML--RESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFL 427
Query: 591 SKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDL 650
++ + N + + + + + + + D+ + WE+ + ++ V +EF+ QG+L
Sbjct: 428 TRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 487
Query: 651 E-KLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
E K +L P+ ++KD +P +Q+GF+ I PL++
Sbjct: 488 EQKFELEISPLC---NQQKDSIPSIQIGFMSYIVEPLFR 523
>AB038040-1|BAA96537.1| 450|Homo sapiens cyclic nucleotide
phosphodiesterase 7B protein.
Length = 450
Score = 117 bits (282), Expect = 2e-25
Identities = 75/279 (26%), Positives = 138/279 (49%), Gaps = 10/279 (3%)
Query: 415 LYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YH 471
++ F FD TL +F L+ F + L R+++ V+++Y YH
Sbjct: 114 MWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYH 173
Query: 472 NWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLA 531
N HA +V Q M LK K+ F++ L+I+ L+A HD+DH G N F KT LA
Sbjct: 174 NAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLA 233
Query: 532 ILY-STSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKK 590
LY + S +E+HH+ + +L + + L +D+ + + IL+TD+ +
Sbjct: 234 NLYQNMSVLENHHWRSTIGML--RESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFL 291
Query: 591 SKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDL 650
++ + N + + + + + + + D+ + WE+ + ++ V +EF+ QG+L
Sbjct: 292 TRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGEL 351
Query: 651 E-KLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYK 688
E K +L P+ ++KD +P +Q+GF+ I PL++
Sbjct: 352 EQKFELEISPLC---NQQKDSIPSIQIGFMSYIVEPLFR 387
>U18088-1|AAA98540.1| 323|Homo sapiens 3',5'-cyclic AMP
phosphodiesterase HSPDE4A7A protein.
Length = 323
Score = 116 bits (280), Expect = 3e-25
Identities = 82/285 (28%), Positives = 142/285 (49%), Gaps = 13/285 (4%)
Query: 406 EIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNY 465
E+ + + L F D+ TC + +F + +L++KF IP D + ++L+++ +Y
Sbjct: 34 ELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTYMLTLEDHY 92
Query: 466 RP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQT 524
V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH G +N F
Sbjct: 93 HADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLI 152
Query: 525 KTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDL 583
T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V +L+TD+
Sbjct: 153 NTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDM 212
Query: 584 AMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAKPWEVQHRI 636
+ + + +V+ + ++ ++L M+ A D+S KP E+ +
Sbjct: 213 SKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTKPLELYRQW 271
Query: 637 AKLVADEFFDQGDLEKLQLNQQPIAMMDREKKD-ELPQMQVGFID 680
+ EFF QGD E+ + + M D+ E Q+Q ID
Sbjct: 272 TDRIMAEFFQQGDRER-ERGMEISPMCDKHTASVEKSQVQARGID 315
>AF069491-4|AAC35014.1| 323|Homo sapiens cAMP specific
phosphodiesterase 4A variant 2EL protein.
Length = 323
Score = 116 bits (280), Expect = 3e-25
Identities = 82/285 (28%), Positives = 142/285 (49%), Gaps = 13/285 (4%)
Query: 406 EIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNY 465
E+ + + L F D+ TC + +F + +L++KF IP D + ++L+++ +Y
Sbjct: 34 ELENLNKWGLNIFCVSDYAGGRSLTCIMYM-IFQERDLLKKFRIPVDTMVTYMLTLEDHY 92
Query: 466 RP-VKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQT 524
V YHN HA +V Q+ +L T ++ +DLEIL L A HD+DH G +N F
Sbjct: 93 HADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLI 152
Query: 525 KTESPLAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDL 583
T S LA++Y+ S +E+HH +L ++ +IFQ LS R + + +V +L+TD+
Sbjct: 153 NTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDM 212
Query: 584 AMYFKKKSKFLELVDNGEFDWQA-------QEKKELLCGMMMTACDVSAIAKPWEVQHRI 636
+ + + +V+ + ++ ++L M+ A D+S KP E+ +
Sbjct: 213 SKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTKPLELYRQW 271
Query: 637 AKLVADEFFDQGDLEKLQLNQQPIAMMDREKKD-ELPQMQVGFID 680
+ EFF QGD E+ + + M D+ E Q+Q ID
Sbjct: 272 TDRIMAEFFQQGDRER-ERGMEISPMCDKHTASVEKSQVQARGID 315
>BC075822-1|AAH75822.1| 829|Homo sapiens phosphodiesterase 8A
protein.
Length = 829
Score = 109 bits (262), Expect = 4e-23
Identities = 83/339 (24%), Positives = 151/339 (44%), Gaps = 29/339 (8%)
Query: 405 DEIPSAETYNLYSFQFHDFDLTDEDTCRAT-------LRMFLQCELVEKFHIPYDVLCRW 457
D++P + + ++ DFD+ + + L+MF + + E H L W
Sbjct: 482 DDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSW 541
Query: 458 ILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+ ++ NY YHN H+ +V L +++ + ++ + L+A HD+DH
Sbjct: 542 LQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHP 601
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESN-NIFQALSPRDYKDVMHVV 574
G N+F S LAILY+ T+ +E HH + + NIF+ + DY+ + +
Sbjct: 602 GRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGI 661
Query: 575 ETAILSTDLAMYFKKKSKFLE--------LVDNGEFD---------WQAQEKKELLCGMM 617
+L+T++ +F+ +KF+ L +NGE D + E + L+ M+
Sbjct: 662 IDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRML 721
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
+ DVS +P + A +++E+F Q D EK Q + + DR +P+ Q+
Sbjct: 722 IKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDR-NTCSIPKSQIS 780
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAE 716
FID ++ D F + L +N + W+ L E
Sbjct: 781 FIDYFITDMFDAW-DAFVDLPDLMQHLDNNFKYWKGLDE 818
>BC060762-1|AAH60762.1| 829|Homo sapiens phosphodiesterase 8A
protein.
Length = 829
Score = 109 bits (262), Expect = 4e-23
Identities = 83/339 (24%), Positives = 151/339 (44%), Gaps = 29/339 (8%)
Query: 405 DEIPSAETYNLYSFQFHDFDLTDEDTCRAT-------LRMFLQCELVEKFHIPYDVLCRW 457
D++P + + ++ DFD+ + + L+MF + + E H L W
Sbjct: 482 DDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSW 541
Query: 458 ILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+ ++ NY YHN H+ +V L +++ + ++ + L+A HD+DH
Sbjct: 542 LQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHP 601
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESN-NIFQALSPRDYKDVMHVV 574
G N+F S LAILY+ T+ +E HH + + NIF+ + DY+ + +
Sbjct: 602 GRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGI 661
Query: 575 ETAILSTDLAMYFKKKSKFLE--------LVDNGEFD---------WQAQEKKELLCGMM 617
+L+T++ +F+ +KF+ L +NGE D + E + L+ M+
Sbjct: 662 IDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRML 721
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
+ DVS +P + A +++E+F Q D EK Q + + DR +P+ Q+
Sbjct: 722 IKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDR-NTCSIPKSQIS 780
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAE 716
FID ++ D F + L +N + W+ L E
Sbjct: 781 FIDYFITDMFDAW-DAFVDLPDLMQHLDNNFKYWKGLDE 818
>AF388187-1|AAL18614.1| 582|Homo sapiens cAMP phosphodiesterase
PDE8A5 protein.
Length = 582
Score = 109 bits (262), Expect = 4e-23
Identities = 83/339 (24%), Positives = 151/339 (44%), Gaps = 29/339 (8%)
Query: 405 DEIPSAETYNLYSFQFHDFDLTDEDTCRAT-------LRMFLQCELVEKFHIPYDVLCRW 457
D++P + + ++ DFD+ + + L+MF + + E H L W
Sbjct: 235 DDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSW 294
Query: 458 ILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+ ++ NY YHN H+ +V L +++ + ++ + L+A HD+DH
Sbjct: 295 LQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHP 354
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESN-NIFQALSPRDYKDVMHVV 574
G N+F S LAILY+ T+ +E HH + + NIF+ + DY+ + +
Sbjct: 355 GRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGI 414
Query: 575 ETAILSTDLAMYFKKKSKFLE--------LVDNGEFD---------WQAQEKKELLCGMM 617
+L+T++ +F+ +KF+ L +NGE D + E + L+ M+
Sbjct: 415 IDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRML 474
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
+ DVS +P + A +++E+F Q D EK Q + + DR +P+ Q+
Sbjct: 475 IKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDR-NTCSIPKSQIS 533
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAE 716
FID ++ D F + L +N + W+ L E
Sbjct: 534 FIDYFITDMFDAW-DAFVDLPDLMQHLDNNFKYWKGLDE 571
>AF388186-1|AAL18613.1| 582|Homo sapiens cAMP phosphodiesterase
PDE8A4 protein.
Length = 582
Score = 109 bits (262), Expect = 4e-23
Identities = 83/339 (24%), Positives = 151/339 (44%), Gaps = 29/339 (8%)
Query: 405 DEIPSAETYNLYSFQFHDFDLTDEDTCRAT-------LRMFLQCELVEKFHIPYDVLCRW 457
D++P + + ++ DFD+ + + L+MF + + E H L W
Sbjct: 235 DDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSW 294
Query: 458 ILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+ ++ NY YHN H+ +V L +++ + ++ + L+A HD+DH
Sbjct: 295 LQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHP 354
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESN-NIFQALSPRDYKDVMHVV 574
G N+F S LAILY+ T+ +E HH + + NIF+ + DY+ + +
Sbjct: 355 GRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGI 414
Query: 575 ETAILSTDLAMYFKKKSKFLE--------LVDNGEFD---------WQAQEKKELLCGMM 617
+L+T++ +F+ +KF+ L +NGE D + E + L+ M+
Sbjct: 415 IDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRML 474
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
+ DVS +P + A +++E+F Q D EK Q + + DR +P+ Q+
Sbjct: 475 IKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDR-NTCSIPKSQIS 533
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAE 716
FID ++ D F + L +N + W+ L E
Sbjct: 534 FIDYFITDMFDAW-DAFVDLPDLMQHLDNNFKYWKGLDE 571
>AF388185-1|AAL18612.1| 449|Homo sapiens cAMP phosphodiesterase
PDE8A3 protein.
Length = 449
Score = 109 bits (262), Expect = 4e-23
Identities = 83/339 (24%), Positives = 151/339 (44%), Gaps = 29/339 (8%)
Query: 405 DEIPSAETYNLYSFQFHDFDLTDEDTCRAT-------LRMFLQCELVEKFHIPYDVLCRW 457
D++P + + ++ DFD+ + + L+MF + + E H L W
Sbjct: 102 DDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSW 161
Query: 458 ILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+ ++ NY YHN H+ +V L +++ + ++ + L+A HD+DH
Sbjct: 162 LQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHP 221
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESN-NIFQALSPRDYKDVMHVV 574
G N+F S LAILY+ T+ +E HH + + NIF+ + DY+ + +
Sbjct: 222 GRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGI 281
Query: 575 ETAILSTDLAMYFKKKSKFLE--------LVDNGEFD---------WQAQEKKELLCGMM 617
+L+T++ +F+ +KF+ L +NGE D + E + L+ M+
Sbjct: 282 IDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRML 341
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
+ DVS +P + A +++E+F Q D EK Q + + DR +P+ Q+
Sbjct: 342 IKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDR-NTCSIPKSQIS 400
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAE 716
FID ++ D F + L +N + W+ L E
Sbjct: 401 FIDYFITDMFDAW-DAFVDLPDLMQHLDNNFKYWKGLDE 438
>AF388184-1|AAL18611.1| 783|Homo sapiens cAMP phosphodiesterase
PDE8A2 protein.
Length = 783
Score = 109 bits (262), Expect = 4e-23
Identities = 83/339 (24%), Positives = 151/339 (44%), Gaps = 29/339 (8%)
Query: 405 DEIPSAETYNLYSFQFHDFDLTDEDTCRAT-------LRMFLQCELVEKFHIPYDVLCRW 457
D++P + + ++ DFD+ + + L+MF + + E H L W
Sbjct: 436 DDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSW 495
Query: 458 ILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+ ++ NY YHN H+ +V L +++ + ++ + L+A HD+DH
Sbjct: 496 LQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHP 555
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESN-NIFQALSPRDYKDVMHVV 574
G N+F S LAILY+ T+ +E HH + + NIF+ + DY+ + +
Sbjct: 556 GRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGI 615
Query: 575 ETAILSTDLAMYFKKKSKFLE--------LVDNGEFD---------WQAQEKKELLCGMM 617
+L+T++ +F+ +KF+ L +NGE D + E + L+ M+
Sbjct: 616 IDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRML 675
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
+ DVS +P + A +++E+F Q D EK Q + + DR +P+ Q+
Sbjct: 676 IKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDR-NTCSIPKSQIS 734
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAE 716
FID ++ D F + L +N + W+ L E
Sbjct: 735 FIDYFITDMFDAW-DAFVDLPDLMQHLDNNFKYWKGLDE 772
>AF388183-1|AAL18610.1| 829|Homo sapiens cAMP phosphodiesterase
PDE8A1 protein.
Length = 829
Score = 109 bits (262), Expect = 4e-23
Identities = 83/339 (24%), Positives = 151/339 (44%), Gaps = 29/339 (8%)
Query: 405 DEIPSAETYNLYSFQFHDFDLTDEDTCRAT-------LRMFLQCELVEKFHIPYDVLCRW 457
D++P + + ++ DFD+ + + L+MF + + E H L W
Sbjct: 482 DDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSW 541
Query: 458 ILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+ ++ NY YHN H+ +V L +++ + ++ + L+A HD+DH
Sbjct: 542 LQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHP 601
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESN-NIFQALSPRDYKDVMHVV 574
G N+F S LAILY+ T+ +E HH + + NIF+ + DY+ + +
Sbjct: 602 GRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGI 661
Query: 575 ETAILSTDLAMYFKKKSKFLE--------LVDNGEFD---------WQAQEKKELLCGMM 617
+L+T++ +F+ +KF+ L +NGE D + E + L+ M+
Sbjct: 662 IDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRML 721
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
+ DVS +P + A +++E+F Q D EK Q + + DR +P+ Q+
Sbjct: 722 IKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDR-NTCSIPKSQIS 780
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAE 716
FID ++ D F + L +N + W+ L E
Sbjct: 781 FIDYFITDMFDAW-DAFVDLPDLMQHLDNNFKYWKGLDE 818
>AF332653-1|AAK57641.1| 829|Homo sapiens cAMP-specific cyclic
nucleotide phosphodiesterase PDE8A1 protein.
Length = 829
Score = 109 bits (262), Expect = 4e-23
Identities = 83/339 (24%), Positives = 151/339 (44%), Gaps = 29/339 (8%)
Query: 405 DEIPSAETYNLYSFQFHDFDLTDEDTCRAT-------LRMFLQCELVEKFHIPYDVLCRW 457
D++P + + ++ DFD+ + + L+MF + + E H L W
Sbjct: 482 DDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSW 541
Query: 458 ILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+ ++ NY YHN H+ +V L +++ + ++ + L+A HD+DH
Sbjct: 542 LQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHP 601
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESN-NIFQALSPRDYKDVMHVV 574
G N+F S LAILY+ T+ +E HH + + NIF+ + DY+ + +
Sbjct: 602 GRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGI 661
Query: 575 ETAILSTDLAMYFKKKSKFLE--------LVDNGEFD---------WQAQEKKELLCGMM 617
+L+T++ +F+ +KF+ L +NGE D + E + L+ M+
Sbjct: 662 IDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRML 721
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
+ DVS +P + A +++E+F Q D EK Q + + DR +P+ Q+
Sbjct: 722 IKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDR-NTCSIPKSQIS 780
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAE 716
FID ++ D F + L +N + W+ L E
Sbjct: 781 FIDYFITDMFDAW-DAFVDLPDLMQHLDNNFKYWKGLDE 818
>AF056490-1|AAC39763.1| 713|Homo sapiens cAMP-specific
phosphodiesterase 8A protein.
Length = 713
Score = 109 bits (262), Expect = 4e-23
Identities = 83/339 (24%), Positives = 151/339 (44%), Gaps = 29/339 (8%)
Query: 405 DEIPSAETYNLYSFQFHDFDLTDEDTCRAT-------LRMFLQCELVEKFHIPYDVLCRW 457
D++P + + ++ DFD+ + + L+MF + + E H L W
Sbjct: 366 DDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSW 425
Query: 458 ILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHR 516
+ ++ NY YHN H+ +V L +++ + ++ + L+A HD+DH
Sbjct: 426 LQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHP 485
Query: 517 GTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESN-NIFQALSPRDYKDVMHVV 574
G N+F S LAILY+ T+ +E HH + + NIF+ + DY+ + +
Sbjct: 486 GRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGI 545
Query: 575 ETAILSTDLAMYFKKKSKFLE--------LVDNGEFD---------WQAQEKKELLCGMM 617
+L+T++ +F+ +KF+ L +NGE D + E + L+ M+
Sbjct: 546 IDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRML 605
Query: 618 MTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVG 677
+ DVS +P + A +++E+F Q D EK Q + + DR +P+ Q+
Sbjct: 606 IKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDR-NTCSIPKSQIS 664
Query: 678 FIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAE 716
FID ++ D F + L +N + W+ L E
Sbjct: 665 FIDYFITDMFDAW-DAFVDLPDLMQHLDNNFKYWKGLDE 702
>BC048317-1|AAH48317.1| 305|Homo sapiens PDE8A protein protein.
Length = 305
Score = 103 bits (246), Expect = 4e-21
Identities = 75/294 (25%), Positives = 132/294 (44%), Gaps = 22/294 (7%)
Query: 443 LVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKMERFMSDLEI 501
+ E H L W+ ++ NY YHN H+ +V L +++ + ++
Sbjct: 3 ICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDE 62
Query: 502 LGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESN-NIF 559
+ L+A HD+DH G N+F S LAILY+ T+ +E HH + + NIF
Sbjct: 63 VAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIF 122
Query: 560 QALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLE--------LVDNGEFD-------- 603
+ + DY+ + + +L+T++ +F+ +KF+ L +NGE D
Sbjct: 123 KNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINT 182
Query: 604 -WQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAM 662
+ E + L+ M++ DVS +P + A +++E+F Q D EK Q + +
Sbjct: 183 MLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPV 242
Query: 663 MDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAE 716
DR +P+ Q+ FID ++ D F + L +N + W+ L E
Sbjct: 243 FDR-NTCSIPKSQISFIDYFITDMFDAW-DAFVDLPDLMQHLDNNFKYWKGLDE 294
>BC035144-1|AAH35144.1| 385|Homo sapiens PDE8B protein protein.
Length = 385
Score = 100 bits (239), Expect = 2e-20
Identities = 74/296 (25%), Positives = 135/296 (45%), Gaps = 18/296 (6%)
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKME 493
L++F + + E + L W ++ NY YHN HA +V L +++
Sbjct: 78 LKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVK 137
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
+ L+ + L+A HD+DH G N+F S LA+LY+ T+ +E HH +
Sbjct: 138 GSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTV 197
Query: 553 SESN-NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN---GEFDWQAQE 608
++ NIF+ + Y+ + + +L+T++ +F+ +KF+ ++ E + E
Sbjct: 198 KDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCE 257
Query: 609 ---------KKELLCGMMMTAC-DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQ 658
+ ++L MM C DV+ +P ++ A +++E+F Q D EK Q
Sbjct: 258 CNPAGKNFLENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPV 317
Query: 659 PIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDL 714
+ + DR +P+ Q+ FID ++ D F + L ADN + W+ L
Sbjct: 318 VMPVFDR-NTCSIPKSQISFIDYFITDMFDAW-DAFAHLPALMQHLADNYKHWKTL 371
>AY423729-1|AAS00492.1| 350|Homo sapiens proliferation-inducing
gene 22 protein protein.
Length = 350
Score = 100 bits (239), Expect = 2e-20
Identities = 74/296 (25%), Positives = 135/296 (45%), Gaps = 18/296 (6%)
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKME 493
L++F + + E + L W ++ NY YHN HA +V L +++
Sbjct: 43 LKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVK 102
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
+ L+ + L+A HD+DH G N+F S LA+LY+ T+ +E HH +
Sbjct: 103 GSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTV 162
Query: 553 SESN-NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN---GEFDWQAQE 608
++ NIF+ + Y+ + + +L+T++ +F+ +KF+ ++ E + E
Sbjct: 163 KDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCE 222
Query: 609 ---------KKELLCGMMMTAC-DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQ 658
+ ++L MM C DV+ +P ++ A +++E+F Q D EK Q
Sbjct: 223 CNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPV 282
Query: 659 PIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDL 714
+ + DR +P+ Q+ FID ++ D F + L ADN + W+ L
Sbjct: 283 VMPVFDR-NTCSIPKSQISFIDYFITDMFDAW-DAFAHLPALMQHLADNYKHWKTL 336
>AY129950-3|AAN71727.1| 788|Homo sapiens cAMP-specific
phosphodiesterase 8B3 protein.
Length = 788
Score = 100 bits (239), Expect = 2e-20
Identities = 74/296 (25%), Positives = 135/296 (45%), Gaps = 18/296 (6%)
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKME 493
L++F + + E + L W ++ NY YHN HA +V L +++
Sbjct: 481 LKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVK 540
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
+ L+ + L+A HD+DH G N+F S LA+LY+ T+ +E HH +
Sbjct: 541 GSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTV 600
Query: 553 SESN-NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN---GEFDWQAQE 608
++ NIF+ + Y+ + + +L+T++ +F+ +KF+ ++ E + E
Sbjct: 601 KDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCE 660
Query: 609 ---------KKELLCGMMMTAC-DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQ 658
+ ++L MM C DV+ +P ++ A +++E+F Q D EK Q
Sbjct: 661 CNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPV 720
Query: 659 PIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDL 714
+ + DR +P+ Q+ FID ++ D F + L ADN + W+ L
Sbjct: 721 VMPVFDR-NTCSIPKSQISFIDYFITDMFDAW-DAFAHLPALMQHLADNYKHWKTL 774
>AY129950-2|AAN71726.1| 838|Homo sapiens cAMP-specific
phosphodiesterase 8B2 protein.
Length = 838
Score = 100 bits (239), Expect = 2e-20
Identities = 74/296 (25%), Positives = 135/296 (45%), Gaps = 18/296 (6%)
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKME 493
L++F + + E + L W ++ NY YHN HA +V L +++
Sbjct: 531 LKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVK 590
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
+ L+ + L+A HD+DH G N+F S LA+LY+ T+ +E HH +
Sbjct: 591 GSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTV 650
Query: 553 SESN-NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN---GEFDWQAQE 608
++ NIF+ + Y+ + + +L+T++ +F+ +KF+ ++ E + E
Sbjct: 651 KDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCE 710
Query: 609 ---------KKELLCGMMMTAC-DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQ 658
+ ++L MM C DV+ +P ++ A +++E+F Q D EK Q
Sbjct: 711 CNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPV 770
Query: 659 PIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDL 714
+ + DR +P+ Q+ FID ++ D F + L ADN + W+ L
Sbjct: 771 VMPVFDR-NTCSIPKSQISFIDYFITDMFDAW-DAFAHLPALMQHLADNYKHWKTL 824
>AY129950-1|AAN71725.1| 885|Homo sapiens cAMP-specific
phosphodiesterase 8B1 protein.
Length = 885
Score = 100 bits (239), Expect = 2e-20
Identities = 74/296 (25%), Positives = 135/296 (45%), Gaps = 18/296 (6%)
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKME 493
L++F + + E + L W ++ NY YHN HA +V L +++
Sbjct: 578 LKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVK 637
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
+ L+ + L+A HD+DH G N+F S LA+LY+ T+ +E HH +
Sbjct: 638 GSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTV 697
Query: 553 SESN-NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN---GEFDWQAQE 608
++ NIF+ + Y+ + + +L+T++ +F+ +KF+ ++ E + E
Sbjct: 698 KDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCE 757
Query: 609 ---------KKELLCGMMMTAC-DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQ 658
+ ++L MM C DV+ +P ++ A +++E+F Q D EK Q
Sbjct: 758 CNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPV 817
Query: 659 PIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDL 714
+ + DR +P+ Q+ FID ++ D F + L ADN + W+ L
Sbjct: 818 VMPVFDR-NTCSIPKSQISFIDYFITDMFDAW-DAFAHLPALMQHLADNYKHWKTL 871
>AY129949-1|AAN71724.1| 788|Homo sapiens cAMP-specific
phosphodiesterase 8B3 protein.
Length = 788
Score = 100 bits (239), Expect = 2e-20
Identities = 74/296 (25%), Positives = 135/296 (45%), Gaps = 18/296 (6%)
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKME 493
L++F + + E + L W ++ NY YHN HA +V L +++
Sbjct: 481 LKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVK 540
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
+ L+ + L+A HD+DH G N+F S LA+LY+ T+ +E HH +
Sbjct: 541 GSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTV 600
Query: 553 SESN-NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN---GEFDWQAQE 608
++ NIF+ + Y+ + + +L+T++ +F+ +KF+ ++ E + E
Sbjct: 601 KDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCE 660
Query: 609 ---------KKELLCGMMMTAC-DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQ 658
+ ++L MM C DV+ +P ++ A +++E+F Q D EK Q
Sbjct: 661 CNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPV 720
Query: 659 PIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDL 714
+ + DR +P+ Q+ FID ++ D F + L ADN + W+ L
Sbjct: 721 VMPVFDR-NTCSIPKSQISFIDYFITDMFDAW-DAFAHLPALMQHLADNYKHWKTL 774
>AY129948-1|AAN71723.1| 838|Homo sapiens cAMP-specific
phosphodiesterase 8B2 protein.
Length = 838
Score = 100 bits (239), Expect = 2e-20
Identities = 74/296 (25%), Positives = 135/296 (45%), Gaps = 18/296 (6%)
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKME 493
L++F + + E + L W ++ NY YHN HA +V L +++
Sbjct: 531 LKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVK 590
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
+ L+ + L+A HD+DH G N+F S LA+LY+ T+ +E HH +
Sbjct: 591 GSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTV 650
Query: 553 SESN-NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN---GEFDWQAQE 608
++ NIF+ + Y+ + + +L+T++ +F+ +KF+ ++ E + E
Sbjct: 651 KDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCE 710
Query: 609 ---------KKELLCGMMMTAC-DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQ 658
+ ++L MM C DV+ +P ++ A +++E+F Q D EK Q
Sbjct: 711 CNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPV 770
Query: 659 PIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDL 714
+ + DR +P+ Q+ FID ++ D F + L ADN + W+ L
Sbjct: 771 VMPVFDR-NTCSIPKSQISFIDYFITDMFDAW-DAFAHLPALMQHLADNYKHWKTL 824
>AL831924-1|CAD38584.1| 843|Homo sapiens hypothetical protein
protein.
Length = 843
Score = 100 bits (239), Expect = 2e-20
Identities = 74/296 (25%), Positives = 135/296 (45%), Gaps = 18/296 (6%)
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKME 493
L++F + + E + L W ++ NY YHN HA +V L +++
Sbjct: 536 LKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVK 595
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
+ L+ + L+A HD+DH G N+F S LA+LY+ T+ +E HH +
Sbjct: 596 GSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTV 655
Query: 553 SESN-NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN---GEFDWQAQE 608
++ NIF+ + Y+ + + +L+T++ +F+ +KF+ ++ E + E
Sbjct: 656 KDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCE 715
Query: 609 ---------KKELLCGMMMTAC-DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQ 658
+ ++L MM C DV+ +P ++ A +++E+F Q D EK Q
Sbjct: 716 CNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPV 775
Query: 659 PIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDL 714
+ + DR +P+ Q+ FID ++ D F + L ADN + W+ L
Sbjct: 776 VMPVFDR-NTCSIPKSQISFIDYFITDMFDAW-DAFAHLPALMQHLADNYKHWKTL 829
>AF079529-1|AAC69564.2| 885|Homo sapiens cAMP-specific
phosphodiesterase 8B1 protein.
Length = 885
Score = 100 bits (239), Expect = 2e-20
Identities = 74/296 (25%), Positives = 135/296 (45%), Gaps = 18/296 (6%)
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKME 493
L++F + + E + L W ++ NY YHN HA +V L +++
Sbjct: 578 LKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVK 637
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
+ L+ + L+A HD+DH G N+F S LA+LY+ T+ +E HH +
Sbjct: 638 GSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTV 697
Query: 553 SESN-NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN---GEFDWQAQE 608
++ NIF+ + Y+ + + +L+T++ +F+ +KF+ ++ E + E
Sbjct: 698 KDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCE 757
Query: 609 ---------KKELLCGMMMTAC-DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQ 658
+ ++L MM C DV+ +P ++ A +++E+F Q D EK Q
Sbjct: 758 CNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPV 817
Query: 659 PIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDL 714
+ + DR +P+ Q+ FID ++ D F + L ADN + W+ L
Sbjct: 818 VMPVFDR-NTCSIPKSQISFIDYFITDMFDAW-DAFAHLPALMQHLADNYKHWKTL 871
>AB085827-1|BAC53765.1| 865|Homo sapiens phosphodiesterase 8B4
protein.
Length = 865
Score = 100 bits (239), Expect = 2e-20
Identities = 74/296 (25%), Positives = 135/296 (45%), Gaps = 18/296 (6%)
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKME 493
L++F + + E + L W ++ NY YHN HA +V L +++
Sbjct: 558 LKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVK 617
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
+ L+ + L+A HD+DH G N+F S LA+LY+ T+ +E HH +
Sbjct: 618 GSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTV 677
Query: 553 SESN-NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN---GEFDWQAQE 608
++ NIF+ + Y+ + + +L+T++ +F+ +KF+ ++ E + E
Sbjct: 678 KDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCE 737
Query: 609 ---------KKELLCGMMMTAC-DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQ 658
+ ++L MM C DV+ +P ++ A +++E+F Q D EK Q
Sbjct: 738 CNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPV 797
Query: 659 PIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDL 714
+ + DR +P+ Q+ FID ++ D F + L ADN + W+ L
Sbjct: 798 VMPVFDR-NTCSIPKSQISFIDYFITDMFDAW-DAFAHLPALMQHLADNYKHWKTL 851
>AB085826-1|BAC53764.1| 830|Homo sapiens phosphodiesterase 8B3
protein.
Length = 830
Score = 100 bits (239), Expect = 2e-20
Identities = 74/296 (25%), Positives = 135/296 (45%), Gaps = 18/296 (6%)
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKME 493
L++F + + E + L W ++ NY YHN HA +V L +++
Sbjct: 523 LKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVK 582
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
+ L+ + L+A HD+DH G N+F S LA+LY+ T+ +E HH +
Sbjct: 583 GSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTV 642
Query: 553 SESN-NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN---GEFDWQAQE 608
++ NIF+ + Y+ + + +L+T++ +F+ +KF+ ++ E + E
Sbjct: 643 KDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCE 702
Query: 609 ---------KKELLCGMMMTAC-DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQ 658
+ ++L MM C DV+ +P ++ A +++E+F Q D EK Q
Sbjct: 703 CNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPV 762
Query: 659 PIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDL 714
+ + DR +P+ Q+ FID ++ D F + L ADN + W+ L
Sbjct: 763 VMPVFDR-NTCSIPKSQISFIDYFITDMFDAW-DAFAHLPALMQHLADNYKHWKTL 816
>AB085825-1|BAC53763.1| 788|Homo sapiens phosphodiestearse 8B2
protein.
Length = 788
Score = 100 bits (239), Expect = 2e-20
Identities = 74/296 (25%), Positives = 135/296 (45%), Gaps = 18/296 (6%)
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKME 493
L++F + + E + L W ++ NY YHN HA +V L +++
Sbjct: 481 LKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVK 540
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
+ L+ + L+A HD+DH G N+F S LA+LY+ T+ +E HH +
Sbjct: 541 GSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTV 600
Query: 553 SESN-NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN---GEFDWQAQE 608
++ NIF+ + Y+ + + +L+T++ +F+ +KF+ ++ E + E
Sbjct: 601 KDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCE 660
Query: 609 ---------KKELLCGMMMTAC-DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQ 658
+ ++L MM C DV+ +P ++ A +++E+F Q D EK Q
Sbjct: 661 CNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPV 720
Query: 659 PIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDL 714
+ + DR +P+ Q+ FID ++ D F + L ADN + W+ L
Sbjct: 721 VMPVFDR-NTCSIPKSQISFIDYFITDMFDAW-DAFAHLPALMQHLADNYKHWKTL 774
>AB085824-1|BAC53762.1| 885|Homo sapiens phosphodiesterase 8B1
protein.
Length = 885
Score = 100 bits (239), Expect = 2e-20
Identities = 74/296 (25%), Positives = 135/296 (45%), Gaps = 18/296 (6%)
Query: 435 LRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YHNWRHALNVAQTMFAMLKTGKME 493
L++F + + E + L W ++ NY YHN HA +V L +++
Sbjct: 578 LKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVK 637
Query: 494 RFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILN 552
+ L+ + L+A HD+DH G N+F S LA+LY+ T+ +E HH +
Sbjct: 638 GSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTV 697
Query: 553 SESN-NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN---GEFDWQAQE 608
++ NIF+ + Y+ + + +L+T++ +F+ +KF+ ++ E + E
Sbjct: 698 KDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCE 757
Query: 609 ---------KKELLCGMMMTAC-DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQ 658
+ ++L MM C DV+ +P ++ A +++E+F Q D EK Q
Sbjct: 758 CNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPV 817
Query: 659 PIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDL 714
+ + DR +P+ Q+ FID ++ D F + L ADN + W+ L
Sbjct: 818 VMPVFDR-NTCSIPKSQISFIDYFITDMFDAW-DAFAHLPALMQHLADNYKHWKTL 871
>U36798-1|AAB18673.1| 1141|Homo sapiens platelet cGI-PDE protein.
Length = 1141
Score = 93.1 bits (221), Expect = 4e-18
Identities = 65/202 (32%), Positives = 99/202 (49%), Gaps = 5/202 (2%)
Query: 488 KTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQ 546
K G + + LE++ L VA HD DH G NAF T +P A+LY+ S +E+HH
Sbjct: 813 KYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAA 872
Query: 547 C-VMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELV-DNGEFDW 604
+ ++ N L ++K +V AIL+TDL +F +KF V D+ DW
Sbjct: 873 AWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDW 932
Query: 605 QAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMD 664
+ + L+C M + D++ AK E+ + + +EF++QGD E+ L MD
Sbjct: 933 TNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGD-EEASLGLPISPFMD 991
Query: 665 REKKDELPQMQVGFIDTICLPL 686
R +L +Q FI I PL
Sbjct: 992 R-SAPQLANLQESFISHIVGPL 1012
Score = 31.9 bits (69), Expect = 9.9
Identities = 15/53 (28%), Positives = 26/53 (49%)
Query: 432 RATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMF 484
+ + R+F L E F IP + +++ YR + YHN HA +V ++
Sbjct: 713 QVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVW 765
>M91667-1|AAA35912.2| 1141|Homo sapiens cGMP-inhibited cAMP
phosphodiesterase protein.
Length = 1141
Score = 93.1 bits (221), Expect = 4e-18
Identities = 65/202 (32%), Positives = 99/202 (49%), Gaps = 5/202 (2%)
Query: 488 KTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQ 546
K G + + LE++ L VA HD DH G NAF T +P A+LY+ S +E+HH
Sbjct: 813 KYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAA 872
Query: 547 C-VMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELV-DNGEFDW 604
+ ++ N L ++K +V AIL+TDL +F +KF V D+ DW
Sbjct: 873 AWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDW 932
Query: 605 QAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMD 664
+ + L+C M + D++ AK E+ + + +EF++QGD E+ L MD
Sbjct: 933 TNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGD-EEASLGLPISPFMD 991
Query: 665 REKKDELPQMQVGFIDTICLPL 686
R +L +Q FI I PL
Sbjct: 992 R-SAPQLANLQESFISHIVGPL 1012
Score = 31.9 bits (69), Expect = 9.9
Identities = 15/53 (28%), Positives = 26/53 (49%)
Query: 432 RATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMF 484
+ + R+F L E F IP + +++ YR + YHN HA +V ++
Sbjct: 713 QVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVW 765
>BC117371-1|AAI17372.1| 1141|Homo sapiens phosphodiesterase 3A,
cGMP-inhibited protein.
Length = 1141
Score = 93.1 bits (221), Expect = 4e-18
Identities = 65/202 (32%), Positives = 99/202 (49%), Gaps = 5/202 (2%)
Query: 488 KTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQ 546
K G + + LE++ L VA HD DH G NAF T +P A+LY+ S +E+HH
Sbjct: 813 KYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAA 872
Query: 547 C-VMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELV-DNGEFDW 604
+ ++ N L ++K +V AIL+TDL +F +KF V D+ DW
Sbjct: 873 AWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDW 932
Query: 605 QAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMD 664
+ + L+C M + D++ AK E+ + + +EF++QGD E+ L MD
Sbjct: 933 TNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGD-EEASLGLPISPFMD 991
Query: 665 REKKDELPQMQVGFIDTICLPL 686
R +L +Q FI I PL
Sbjct: 992 R-SAPQLANLQESFISHIVGPL 1012
Score = 31.9 bits (69), Expect = 9.9
Identities = 15/53 (28%), Positives = 26/53 (49%)
Query: 432 RATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMF 484
+ + R+F L E F IP + +++ YR + YHN HA +V ++
Sbjct: 713 QVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVW 765
>BC117369-1|AAI17370.1| 1141|Homo sapiens phosphodiesterase 3A,
cGMP-inhibited protein.
Length = 1141
Score = 93.1 bits (221), Expect = 4e-18
Identities = 65/202 (32%), Positives = 99/202 (49%), Gaps = 5/202 (2%)
Query: 488 KTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQ 546
K G + + LE++ L VA HD DH G NAF T +P A+LY+ S +E+HH
Sbjct: 813 KYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAA 872
Query: 547 C-VMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELV-DNGEFDW 604
+ ++ N L ++K +V AIL+TDL +F +KF V D+ DW
Sbjct: 873 AWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDW 932
Query: 605 QAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMD 664
+ + L+C M + D++ AK E+ + + +EF++QGD E+ L MD
Sbjct: 933 TNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGD-EEASLGLPISPFMD 991
Query: 665 REKKDELPQMQVGFIDTICLPL 686
R +L +Q FI I PL
Sbjct: 992 R-SAPQLANLQESFISHIVGPL 1012
Score = 31.9 bits (69), Expect = 9.9
Identities = 15/53 (28%), Positives = 26/53 (49%)
Query: 432 RATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMF 484
+ + R+F L E F IP + +++ YR + YHN HA +V ++
Sbjct: 713 QVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVW 765
>AJ005036-1|CAA06304.1| 1141|Homo sapiens phosphodiesterase 3A
protein.
Length = 1141
Score = 93.1 bits (221), Expect = 4e-18
Identities = 65/202 (32%), Positives = 99/202 (49%), Gaps = 5/202 (2%)
Query: 488 KTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQ 546
K G + + LE++ L VA HD DH G NAF T +P A+LY+ S +E+HH
Sbjct: 813 KYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAA 872
Query: 547 C-VMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELV-DNGEFDW 604
+ ++ N L ++K +V AIL+TDL +F +KF V D+ DW
Sbjct: 873 AWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDW 932
Query: 605 QAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMD 664
+ + L+C M + D++ AK E+ + + +EF++QGD E+ L MD
Sbjct: 933 TNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGD-EEASLGLPISPFMD 991
Query: 665 REKKDELPQMQVGFIDTICLPL 686
R +L +Q FI I PL
Sbjct: 992 R-SAPQLANLQESFISHIVGPL 1012
Score = 31.9 bits (69), Expect = 9.9
Identities = 15/53 (28%), Positives = 26/53 (49%)
Query: 432 RATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMF 484
+ + R+F L E F IP + +++ YR + YHN HA +V ++
Sbjct: 713 QVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVW 765
>U66349-1|AAB96878.1| 427|Homo sapiens PDE4C-delta109 protein.
Length = 427
Score = 91.5 bits (217), Expect = 1e-17
Identities = 73/251 (29%), Positives = 116/251 (46%), Gaps = 12/251 (4%)
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E+
Sbjct: 129 TDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAEN 188
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQEK 609
+IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 189 CDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSD 248
Query: 610 KELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREKK 668
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 249 RIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHTA 306
Query: 669 DELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWIDH 727
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 307 -SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPER 365
Query: 728 DTIDKPVEEFT 738
D D+ E T
Sbjct: 366 DGPDRFQFELT 376
>AC005759-4|AAC83048.1| 427|Homo sapiens PDE4C-delta109 protein.
Length = 427
Score = 91.5 bits (217), Expect = 1e-17
Identities = 73/251 (29%), Positives = 116/251 (46%), Gaps = 12/251 (4%)
Query: 497 SDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSES 555
+DLEIL L A HD+DH G +N F T S LA++Y+ S +E+HH +L +E+
Sbjct: 129 TDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAEN 188
Query: 556 NNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFDWQAQEK 609
+IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 189 CDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSD 248
Query: 610 KELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAMMDREKK 668
+ + ++ D+S KP + + + EFF QGD E+ L+ P M D+
Sbjct: 249 RIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--MCDKHTA 306
Query: 669 DELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWIDH 727
+ + QVGFID I PL++ +D P L DNR +Q + LT +
Sbjct: 307 -SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPER 365
Query: 728 DTIDKPVEEFT 738
D D+ E T
Sbjct: 366 DGPDRFQFELT 376
>U40584-1|AAB50018.1| 184|Homo sapiens
calcium/calmodulin-stimulated cyclic nucleotide
phosphodiesterase protein.
Length = 184
Score = 89.8 bits (213), Expect = 4e-17
Identities = 49/167 (29%), Positives = 88/167 (52%), Gaps = 6/167 (3%)
Query: 470 YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESP 529
YHN HA +V QT+ L M +S++E+L ++ A HD +H GT N+F +T+S
Sbjct: 22 YHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSE 81
Query: 530 LAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFK 588
AI+Y+ S +E+HH ++ + NIF L+ ++ ++ +V +L+TD++ +F+
Sbjct: 82 CAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQ 141
Query: 589 KKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHR 635
+ + E + + K L +++ A D+S K W V R
Sbjct: 142 QVKTMKTALQQLE---RIDKSKAL--SLLLHAADISHPTKQWLVHSR 183
>X95520-1|CAA64774.1| 1112|Homo sapiens cyclic nucleotide
phosphodiesterase protein.
Length = 1112
Score = 88.2 bits (209), Expect = 1e-16
Identities = 59/193 (30%), Positives = 97/193 (50%), Gaps = 7/193 (3%)
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQC-VMILNSESN 556
LE++ L VA HD DH G NAF T +P A+LY+ S +E+HH + L+
Sbjct: 809 LELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEY 868
Query: 557 NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKF---LELVDNGEFDWQAQEKKELL 613
N L ++K +V AIL+TDL +F ++F V++ +W + + L+
Sbjct: 869 NFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLV 928
Query: 614 CGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQ 673
C + + D++ AK ++ + + + +EF++QGD E+ L MDR +L +
Sbjct: 929 CQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGD-EEANLGLPISPFMDR-SSPQLAK 986
Query: 674 MQVGFIDTICLPL 686
+Q FI I PL
Sbjct: 987 LQESFITHIVGPL 999
Score = 31.9 bits (69), Expect = 9.9
Identities = 14/48 (29%), Positives = 24/48 (50%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMF 484
+F L+E F IP + +++ YR + YHN HA +V ++
Sbjct: 703 LFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVW 750
>U38178-1|AAC50724.1| 1112|Homo sapiens cyclic nucleotide
phophodiesterase protein.
Length = 1112
Score = 88.2 bits (209), Expect = 1e-16
Identities = 59/193 (30%), Positives = 97/193 (50%), Gaps = 7/193 (3%)
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQC-VMILNSESN 556
LE++ L VA HD DH G NAF T +P A+LY+ S +E+HH + L+
Sbjct: 809 LELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEY 868
Query: 557 NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKF---LELVDNGEFDWQAQEKKELL 613
N L ++K +V AIL+TDL +F ++F V++ +W + + L+
Sbjct: 869 NFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLV 928
Query: 614 CGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQ 673
C + + D++ AK ++ + + + +EF++QGD E+ L MDR +L +
Sbjct: 929 CQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGD-EEANLGLPISPFMDR-SSPQLAK 986
Query: 674 MQVGFIDTICLPL 686
+Q FI I PL
Sbjct: 987 LQESFITHIVGPL 999
Score = 31.9 bits (69), Expect = 9.9
Identities = 14/48 (29%), Positives = 24/48 (50%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMF 484
+F L+E F IP + +++ YR + YHN HA +V ++
Sbjct: 703 LFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVW 750
>D50640-1|BAA09306.1| 1112|Homo sapiens phosphodiesterase 3B
protein.
Length = 1112
Score = 88.2 bits (209), Expect = 1e-16
Identities = 59/193 (30%), Positives = 97/193 (50%), Gaps = 7/193 (3%)
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQC-VMILNSESN 556
LE++ L VA HD DH G NAF T +P A+LY+ S +E+HH + L+
Sbjct: 809 LELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEY 868
Query: 557 NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKF---LELVDNGEFDWQAQEKKELL 613
N L ++K +V AIL+TDL +F ++F V++ +W + + L+
Sbjct: 869 NFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLV 928
Query: 614 CGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQ 673
C + + D++ AK ++ + + + +EF++QGD E+ L MDR +L +
Sbjct: 929 CQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGD-EEANLGLPISPFMDR-SSPQLAK 986
Query: 674 MQVGFIDTICLPL 686
+Q FI I PL
Sbjct: 987 LQESFITHIVGPL 999
Score = 31.9 bits (69), Expect = 9.9
Identities = 14/48 (29%), Positives = 24/48 (50%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMF 484
+F L+E F IP + +++ YR + YHN HA +V ++
Sbjct: 703 LFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVW 750
>AY459346-1|AAR24292.1| 1112|Homo sapiens cGMP-inhibited cAMP
phophodiesterase protein.
Length = 1112
Score = 88.2 bits (209), Expect = 1e-16
Identities = 59/193 (30%), Positives = 97/193 (50%), Gaps = 7/193 (3%)
Query: 499 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQC-VMILNSESN 556
LE++ L VA HD DH G NAF T +P A+LY+ S +E+HH + L+
Sbjct: 809 LELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEY 868
Query: 557 NIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKF---LELVDNGEFDWQAQEKKELL 613
N L ++K +V AIL+TDL +F ++F V++ +W + + L+
Sbjct: 869 NFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLV 928
Query: 614 CGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQ 673
C + + D++ AK ++ + + + +EF++QGD E+ L MDR +L +
Sbjct: 929 CQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGD-EEANLGLPISPFMDR-SSPQLAK 986
Query: 674 MQVGFIDTICLPL 686
+Q FI I PL
Sbjct: 987 LQESFITHIVGPL 999
Score = 31.9 bits (69), Expect = 9.9
Identities = 14/48 (29%), Positives = 24/48 (50%)
Query: 437 MFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMF 484
+F L+E F IP + +++ YR + YHN HA +V ++
Sbjct: 703 LFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVW 750
>AC073892-1|AAY24130.1| 98|Homo sapiens unknown protein.
Length = 98
Score = 84.6 bits (200), Expect = 1e-15
Identities = 39/72 (54%), Positives = 53/72 (73%)
Query: 157 VFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKIMTEARDL 216
V + YL FCGI I NAQLF +S EY+R++ LL + +FEEQ++LE +V KIM A+ L
Sbjct: 1 VMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTL 60
Query: 217 LKCERCAVFILD 228
LKCERC+V +L+
Sbjct: 61 LKCERCSVLLLE 72
>M94539-1|AAA58405.1| 116|Homo sapiens cyclic nucleotide
phosphodiesterase protein.
Length = 116
Score = 83.0 bits (196), Expect = 4e-15
Identities = 39/116 (33%), Positives = 67/116 (57%), Gaps = 1/116 (0%)
Query: 470 YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESP 529
YHN HA +V QT+ L M +S++E+L ++ A HD +H GT N+F +T+S
Sbjct: 1 YHNSMHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSE 60
Query: 530 LAILYS-TSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLA 584
AI+Y+ S +E+HH ++ + NIF L+ ++ ++ +V +L+TD+A
Sbjct: 61 CAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMA 116
>AY266363-1|AAP31235.1| 255|Homo sapiens phosphodiesterase isozyme
5 protein.
Length = 255
Score = 83.0 bits (196), Expect = 4e-15
Identities = 41/97 (42%), Positives = 63/97 (64%), Gaps = 2/97 (2%)
Query: 138 LRRKLSHSGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFE 197
+ +K + G+ F+ +D + F YL F GI + NAQL+E+S+LE KRNQ+LL LA IFE
Sbjct: 129 INKKSGNGGT--FTEKDEKDFAAYLAFGGIVLHNAQLYETSLLENKRNQVLLDLASLIFE 186
Query: 198 EQSNLECLVTKIMTEARDLLKCERCAVFILDTDHCES 234
EQ +LE ++ KI ++ ++C +FI+D D +S
Sbjct: 187 EQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDS 223
Score = 62.1 bits (144), Expect = 8e-09
Identities = 49/164 (29%), Positives = 78/164 (47%), Gaps = 11/164 (6%)
Query: 291 VARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINK----- 345
VA + LNI D + R N +++LCMPI N ++V+GVAQ INK
Sbjct: 77 VAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNG 136
Query: 346 --FTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSKLC 403
FTE D F A+ F G+ +HN Q+YE + + +V L+ S + + ++
Sbjct: 137 GTFTEKDEKDFAAYLAFGGIVLHNAQLYETSLLENKRNQVLLDLAS--LIFEEQQSLEVI 194
Query: 404 QDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMF-LQCELVEK 446
+I +A + Q + DED + +F ++CE +EK
Sbjct: 195 LKKI-AATIISFMQVQKCTIFIVDEDCSDSFFSVFHMECEELEK 237
Score = 59.7 bits (138), Expect = 4e-08
Identities = 28/50 (56%), Positives = 35/50 (70%)
Query: 55 QFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLD 104
+FN+E+D TGYKT+ ILCMPI N+ +VVGVAQ INK G T + D
Sbjct: 94 RFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKD 143
>BC047627-1|AAH47627.1| 241|Homo sapiens PDE8B protein protein.
Length = 241
Score = 81.8 bits (193), Expect = 9e-15
Identities = 59/225 (26%), Positives = 106/225 (47%), Gaps = 17/225 (7%)
Query: 505 LVACLCHDLDHRGTNNAFQTKTESPLAILYS-TSTMEHHHFDQCVMILNSESN-NIFQAL 562
L+A HD+DH G N+F S LA+LY+ T+ +E HH + ++ NIF+ +
Sbjct: 5 LIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNI 64
Query: 563 SPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN---GEFDWQAQE---------KK 610
Y+ + + +L+T++ +F+ +KF+ ++ E + E +
Sbjct: 65 DRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN 124
Query: 611 ELLCGMMMTAC-DVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKD 669
++L MM C DV+ +P ++ A +++E+F Q D EK Q + + DR
Sbjct: 125 QILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDR-NTC 183
Query: 670 ELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDL 714
+P+ Q+ FID ++ D F + L ADN + W+ L
Sbjct: 184 SIPKSQISFIDYFITDMFDAW-DAFAHLPALMQHLADNYKHWKTL 227
>AL138828-3|CAI95286.1| 199|Homo sapiens phosphodiesterase 7B
protein.
Length = 199
Score = 66.5 bits (155), Expect = 4e-10
Identities = 41/123 (33%), Positives = 60/123 (48%), Gaps = 3/123 (2%)
Query: 415 LYSFQFHDFDLTDEDTCRATL--RMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVK-YH 471
++ F FD TL +F L+ F + L R+++ V+++Y YH
Sbjct: 8 MWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYH 67
Query: 472 NWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLA 531
N HA +V Q M LK K+ F++ L+I+ L+A HD+DH G N F KT LA
Sbjct: 68 NAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLA 127
Query: 532 ILY 534
LY
Sbjct: 128 NLY 130
>U86077-1|AAC51871.1| 71|Homo sapiens calmodulin-stimulated
phosphodiesterase PDE1B1 protein.
Length = 71
Score = 59.3 bits (137), Expect = 6e-08
Identities = 26/66 (39%), Positives = 40/66 (60%)
Query: 470 YHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESP 529
YHN HA +V QT+ L M +S++E+L ++ A HD +H GT N+F +T+S
Sbjct: 1 YHNLIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSE 60
Query: 530 LAILYS 535
AI+Y+
Sbjct: 61 CAIVYN 66
>L20968-1|AAA03591.1| 251|Homo sapiens phosphodiesterase protein.
Length = 251
Score = 49.2 bits (112), Expect = 6e-05
Identities = 50/197 (25%), Positives = 85/197 (43%), Gaps = 11/197 (5%)
Query: 550 ILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDN------GEFD 603
+L +E+ +IFQ LS + + +V +L+TD++ + + +V+ G
Sbjct: 7 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 66
Query: 604 WQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQ-LNQQPIAM 662
+ + ++ D+S KP + + + EFF QGD E+ L+ P M
Sbjct: 67 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISP--M 124
Query: 663 MDREKKDELPQMQVGFIDTICLPLYKVLSD-TFPWMTPLRTGTADNRRRWQDLAEKVDMG 721
D+ + + QVGFID I PL++ +D P L DNR +Q +
Sbjct: 125 CDKHTA-SVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSD 183
Query: 722 LTWIDHDTIDKPVEEFT 738
LT + D D+ E T
Sbjct: 184 LTNPERDGPDRFQFELT 200
>AL109778-1|CAB52432.1| 178|Homo sapiens PDE8A; phosphodiesterase
8A protein.
Length = 178
Score = 46.8 bits (106), Expect = 3e-04
Identities = 41/168 (24%), Positives = 75/168 (44%), Gaps = 19/168 (11%)
Query: 566 DYKDVMHVVETAILSTDLAMYFKKKSKFLE--------LVDNGEFDWQAQ---------E 608
DY+ + + +L+T++ +F+ +KF+ L +NGE D + E
Sbjct: 2 DYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPE 61
Query: 609 KKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKK 668
+ L+ M++ DVS +P + A +++E+F Q D EK Q + + DR
Sbjct: 62 NRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDR-NT 120
Query: 669 DELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAE 716
+P+ Q+ FID ++ D F + L +N + W+ L E
Sbjct: 121 CSIPKSQISFIDYFITDMFDAW-DAFVDLPDLMQHLDNNFKYWKGLDE 167
>AY266362-1|AAP31234.1| 102|Homo sapiens phosphodiesterase isozyme
4 protein.
Length = 102
Score = 40.7 bits (91), Expect = 0.021
Identities = 25/76 (32%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Query: 617 MMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQV 676
M+ D+S KP E+ + + EFF QGD E+ + + M D+ + + QV
Sbjct: 28 MVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRER-ERGMEISPMCDKHTA-SVEKSQV 85
Query: 677 GFIDTICLPLYKVLSD 692
GFID I PL++ +D
Sbjct: 86 GFIDYIVHPLWETWAD 101
>AL109687-1|CAB52020.1| 160|Homo sapiens PDE8A; phosphodiesterase
8A protein.
Length = 160
Score = 40.7 bits (91), Expect = 0.021
Identities = 29/109 (26%), Positives = 50/109 (45%), Gaps = 2/109 (1%)
Query: 608 EKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREK 667
E + L+ M++ DVS +P + A +++E+F Q D EK Q + + DR
Sbjct: 43 ENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDR-N 101
Query: 668 KDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAE 716
+P+ Q+ FID ++ D F + L +N + W+ L E
Sbjct: 102 TCSIPKSQISFIDYFITDMFDAW-DAFVDLPDLMQHLDNNFKYWKGLDE 149
>X62693-1|CAA44570.1| 51|Homo sapiens cGMP phosphodiesterase beta
subunit protein.
Length = 51
Score = 34.3 bits (75), Expect = 1.9
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Query: 56 FNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGEHTTESTLD 104
F+S D T YKT+ +L PI N + DVV V +NK +G T D
Sbjct: 4 FSSFADELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDED 51
>AF071787-1|AAC80000.1| 1533|Homo sapiens melastatin 1 protein.
Length = 1533
Score = 32.7 bits (71), Expect = 5.7
Identities = 17/43 (39%), Positives = 25/43 (58%)
Query: 392 ATASAEDTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRAT 434
A++ E T L Q I SA+ Y+LY + F+ +L EDT +T
Sbjct: 1179 ASSECEATYLLRQSSINSADGYSLYRYHFNGEELLFEDTSLST 1221
>AB115502-1|BAC80204.1| 1527|Homo sapiens melastatin 1 splicing
variant protein.
Length = 1527
Score = 32.7 bits (71), Expect = 5.7
Identities = 17/43 (39%), Positives = 25/43 (58%)
Query: 392 ATASAEDTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRAT 434
A++ E T L Q I SA+ Y+LY + F+ +L EDT +T
Sbjct: 1173 ASSECEATYLLRQSSINSADGYSLYRYHFNGEELLFEDTSLST 1215
>AB115501-1|BAC80203.1| 1533|Homo sapiens melastatin 1 protein.
Length = 1533
Score = 32.7 bits (71), Expect = 5.7
Identities = 17/43 (39%), Positives = 25/43 (58%)
Query: 392 ATASAEDTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRAT 434
A++ E T L Q I SA+ Y+LY + F+ +L EDT +T
Sbjct: 1179 ASSECEATYLLRQSSINSADGYSLYRYHFNGEELLFEDTSLST 1221
>AB115499-1|BAC80201.1| 1533|Homo sapiens melastatin 1 protein.
Length = 1533
Score = 32.7 bits (71), Expect = 5.7
Identities = 17/43 (39%), Positives = 25/43 (58%)
Query: 392 ATASAEDTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRAT 434
A++ E T L Q I SA+ Y+LY + F+ +L EDT +T
Sbjct: 1179 ASSECEATYLLRQSSINSADGYSLYRYHFNGEELLFEDTSLST 1221
>AB115498-1|BAC80200.1| 1533|Homo sapiens melastatin 1 protein.
Length = 1533
Score = 32.7 bits (71), Expect = 5.7
Identities = 17/43 (39%), Positives = 25/43 (58%)
Query: 392 ATASAEDTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRAT 434
A++ E T L Q I SA+ Y+LY + F+ +L EDT +T
Sbjct: 1179 ASSECEATYLLRQSSINSADGYSLYRYHFNGEELLFEDTSLST 1221
>X91625-1|CAA62823.1| 383|Homo sapiens MHC class I antigen protein.
Length = 383
Score = 32.3 bits (70), Expect = 7.5
Identities = 17/52 (32%), Positives = 27/52 (51%)
Query: 624 SAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQ 675
+A A+P +++ + L DE G L + L+ QP DR+K+ PQ Q
Sbjct: 20 AAAAEPHSLRYNLMVLSQDESVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQ 71
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.321 0.134 0.410
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 113,366,481
Number of Sequences: 224733
Number of extensions: 4442804
Number of successful extensions: 12573
Number of sequences better than 10.0: 228
Number of HSP's better than 10.0 without gapping: 223
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 11471
Number of HSP's gapped (non-prelim): 447
length of query: 852
length of database: 73,234,838
effective HSP length: 96
effective length of query: 756
effective length of database: 51,660,470
effective search space: 39055315320
effective search space used: 39055315320
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 69 (31.9 bits)
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