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Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= e96h0127
         (700 letters)

Database: uniref50 
           1,657,284 sequences; 575,637,011 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q9VH08 Cluster: CG6284-PA; n=9; Eumetazoa|Rep: CG6284-P...   132   8e-30
UniRef50_Q8N6T7-2 Cluster: Isoform 2 of Q8N6T7 ; n=5; Catarrhini...   101   1e-20
UniRef50_Q8N6T7 Cluster: Mono-ADP-ribosyltransferase sirtuin-6; ...   101   1e-20
UniRef50_Q9FE17 Cluster: Sir2-like protein; n=9; Magnoliophyta|R...    89   1e-16
UniRef50_Q7SB01 Cluster: Putative uncharacterized protein NCU076...    81   3e-14
UniRef50_Q4UH74 Cluster: Sir2-like histone deacetylase, putative...    78   2e-13
UniRef50_A5K3P4 Cluster: Putative uncharacterized protein; n=1; ...    78   2e-13
UniRef50_A5AF92 Cluster: Putative uncharacterized protein; n=1; ...    77   4e-13
UniRef50_Q7RP35 Cluster: Sir2-like protein; n=5; Plasmodium (Vin...    77   6e-13
UniRef50_UPI0000D573CE Cluster: PREDICTED: similar to CG11305-PA...    75   2e-12
UniRef50_Q1MT39 Cluster: Novel protein similar to vertebratesirt...    73   7e-12
UniRef50_A7AWG1 Cluster: Transcriptional regulator, Sir2 family ...    73   7e-12
UniRef50_Q8N6T7-3 Cluster: Isoform 3 of Q8N6T7 ; n=2; Catarrhini...    71   2e-11
UniRef50_Q8IKW2 Cluster: Putative uncharacterized protein; n=1; ...    71   2e-11
UniRef50_Q9NRC8 Cluster: NAD-dependent deacetylase sirtuin-7; n=...    71   2e-11
UniRef50_Q175I4 Cluster: Chromatin regulatory protein sir2; n=3;...    69   1e-10
UniRef50_UPI00015B56BB Cluster: PREDICTED: similar to ENSANGP000...    64   3e-09
UniRef50_Q9VAQ1 Cluster: CG11305-PA; n=8; Coelomata|Rep: CG11305...    62   2e-08
UniRef50_Q29QS4 Cluster: IP11347p; n=1; Drosophila melanogaster|...    61   2e-08
UniRef50_UPI000049979A Cluster: Sir2 family transcriptional regu...    57   4e-07
UniRef50_Q22KA8 Cluster: Transcriptional regulator, Sir2 family ...    56   8e-07
UniRef50_Q3F1F4 Cluster: SIR2 family protein; n=1; Bacillus thur...    55   2e-06
UniRef50_A6DC77 Cluster: Silent information regulator protein Si...    55   2e-06
UniRef50_A4M603 Cluster: Silent information regulator protein Si...    53   8e-06
UniRef50_Q974M6 Cluster: NAD-dependent deacetylase; n=8; Thermop...    53   8e-06
UniRef50_A3ZMQ7 Cluster: Sir2 family, possible ADP ribosyltransf...    52   1e-05
UniRef50_Q89LY4 Cluster: NAD-dependent deacetylase 1; n=12; Prot...    52   1e-05
UniRef50_Q95Q89 Cluster: Yeast sir related protein 2.4; n=2; Cae...    51   2e-05
UniRef50_Q8ZT00 Cluster: NAD-dependent deacetylase 2; n=2; cellu...    51   3e-05
UniRef50_Q3A6W7 Cluster: NAD-dependent protein deacetylases, SIR...    50   4e-05
UniRef50_Q54GV7 Cluster: NAD(+)-dependent deacetylase, silent in...    50   5e-05
UniRef50_A7EMW8 Cluster: Putative uncharacterized protein; n=1; ...    50   7e-05
UniRef50_UPI00006CB0CC Cluster: transcriptional regulator, Sir2 ...    49   1e-04
UniRef50_UPI000049971A Cluster: Sir2 family transcriptional regu...    49   1e-04
UniRef50_Q5YR82 Cluster: Putative Sir2 family regulator; n=1; No...    49   1e-04
UniRef50_Q0AY57 Cluster: Regulatory protein, sir2 family; n=1; S...    49   1e-04
UniRef50_UPI00015B57C0 Cluster: PREDICTED: similar to GA18743-PA...    49   1e-04
UniRef50_Q9WYW0 Cluster: NAD-dependent deacetylase; n=4; Thermot...    49   1e-04
UniRef50_Q8ZU41 Cluster: NAD-dependent deacetylase 1; n=3; Pyrob...    49   1e-04
UniRef50_Q2LSF2 Cluster: Sir2 family of NAD+-dependent deacetyla...    48   2e-04
UniRef50_Q8CJM9 Cluster: NAD-dependent deacetylase 2; n=3; Actin...    48   2e-04
UniRef50_Q2YZT2 Cluster: Putative uncharacterized protein; n=1; ...    48   2e-04
UniRef50_A7B9E8 Cluster: Putative uncharacterized protein; n=1; ...    48   3e-04
UniRef50_A6RRE3 Cluster: Putative uncharacterized protein; n=1; ...    48   3e-04
UniRef50_Q5KZE8 Cluster: NAD-dependent deacetylase 2; n=3; Bacte...    48   3e-04
UniRef50_UPI0000E49846 Cluster: PREDICTED: similar to Sirtuin (s...    47   4e-04
UniRef50_Q5KA61 Cluster: Histone deacetylase, putative; n=1; Fil...    47   4e-04
UniRef50_A6R1B0 Cluster: Predicted protein; n=2; Onygenales|Rep:...    47   4e-04
UniRef50_A2Q9C4 Cluster: Contig An01c0250, complete genome; n=18...    47   4e-04
UniRef50_O96505 Cluster: SIR2; n=4; Sophophora|Rep: SIR2 - Droso...    47   5e-04
UniRef50_Q5AQ47 Cluster: Potential Sir2 family histone deacetyla...    47   5e-04
UniRef50_Q8REC3 Cluster: NAD-dependent deacetylase; n=3; Fusobac...    47   5e-04
UniRef50_Q8R984 Cluster: NAD-dependent deacetylase 2; n=1; Therm...    47   5e-04
UniRef50_Q23A43 Cluster: Transcriptional regulator, Sir2 family ...    46   7e-04
UniRef50_Q1RPU3 Cluster: Zinc finger protein; n=1; Ciona intesti...    46   7e-04
UniRef50_A7DQD6 Cluster: Silent information regulator protein Si...    46   7e-04
UniRef50_Q21921 Cluster: NAD-dependent deacetylase SIR2 homolog;...    46   7e-04
UniRef50_O07595 Cluster: NAD-dependent deacetylase; n=3; Bacillu...    46   7e-04
UniRef50_A6TNA0 Cluster: Silent information regulator protein Si...    46   9e-04
UniRef50_A6G0H3 Cluster: Silent information regulator protein Si...    46   9e-04
UniRef50_A0NQ49 Cluster: Silent information regulator protein Si...    46   9e-04
UniRef50_Q2GZ88 Cluster: Putative uncharacterized protein; n=1; ...    46   9e-04
UniRef50_A6PTK3 Cluster: Silent information regulator protein Si...    46   0.001
UniRef50_A5UYK2 Cluster: Silent information regulator protein Si...    46   0.001
UniRef50_Q5BVF7 Cluster: SJCHGC03105 protein; n=2; Schistosoma j...    46   0.001
UniRef50_Q12Y78 Cluster: Silent information regulator protein Si...    46   0.001
UniRef50_Q73KE1 Cluster: NAD-dependent deacetylase; n=1; Trepone...    46   0.001
UniRef50_A6P1S7 Cluster: Putative uncharacterized protein; n=2; ...    45   0.002
UniRef50_A0LG97 Cluster: Silent information regulator protein Si...    45   0.002
UniRef50_Q9FY91 Cluster: SIR2-family protein; n=12; Magnoliophyt...    45   0.002
UniRef50_A7SX90 Cluster: Predicted protein; n=3; Eumetazoa|Rep: ...    45   0.002
UniRef50_A7EC18 Cluster: Putative uncharacterized protein; n=1; ...    45   0.002
UniRef50_Q8CNF4 Cluster: NAD-dependent deacetylase; n=17; Staphy...    45   0.002
UniRef50_UPI0000D55B5A Cluster: PREDICTED: similar to CG5216-PA;...    45   0.002
UniRef50_UPI000051AA14 Cluster: PREDICTED: similar to NAD-depend...    45   0.002
UniRef50_Q23E36 Cluster: Transcriptional regulator, Sir2 family ...    45   0.002
UniRef50_A2F8E1 Cluster: Transcriptional regulator, Sir2 family ...    45   0.002
UniRef50_Q7S386 Cluster: Putative uncharacterized protein NCU048...    45   0.002
UniRef50_Q6CB00 Cluster: Similarities with tr|Q9UR39 Schizosacch...    45   0.002
UniRef50_Q0CR31 Cluster: NAD-dependent histone deacetylase SIR2;...    45   0.002
UniRef50_A6RSV6 Cluster: Putative uncharacterized protein; n=2; ...    45   0.002
UniRef50_Q0LIC7 Cluster: Silent information regulator protein Si...    44   0.003
UniRef50_A6DES9 Cluster: Transcriptional regulator, Sir2 family ...    44   0.003
UniRef50_Q6CQA7 Cluster: Kluyveromyces lactis strain NRRL Y-1140...    44   0.003
UniRef50_Q0UNC9 Cluster: Putative uncharacterized protein; n=1; ...    44   0.003
UniRef50_A6RXY5 Cluster: Putative uncharacterized protein; n=2; ...    44   0.003
UniRef50_A1DG07 Cluster: SIR2 family histone deacetylase, putati...    44   0.003
UniRef50_Q88ZA0 Cluster: NAD-dependent deacetylase; n=4; Lactoba...    44   0.003
UniRef50_UPI000023F1DF Cluster: hypothetical protein FG02466.1; ...    44   0.004
UniRef50_A7HL19 Cluster: Silent information regulator protein Si...    44   0.004
UniRef50_A4JS80 Cluster: Silent information regulator protein Si...    44   0.004
UniRef50_Q875P9 Cluster: HST1; n=1; Lachancea kluyveri|Rep: HST1...    44   0.004
UniRef50_Q7S6G9 Cluster: Putative uncharacterized protein NCU047...    44   0.004
UniRef50_Q6C8V5 Cluster: Similar to tr|Q9FY91 Arabidopsis thalia...    44   0.004
UniRef50_Q4WT50 Cluster: SIR2 family histone deacetylase (Hst4),...    44   0.004
UniRef50_Q5L014 Cluster: NAD-dependent deacetylase 1; n=7; Bacil...    44   0.004
UniRef50_A1ZPG8 Cluster: NAD-dependent deacetylase; n=1; Microsc...    44   0.005
UniRef50_Q7SCL4 Cluster: Putative uncharacterized protein NCU005...    44   0.005
UniRef50_A1HLU5 Cluster: Silent information regulator protein Si...    43   0.006
UniRef50_A7TQE2 Cluster: Putative uncharacterized protein; n=1; ...    43   0.006
UniRef50_A2QFF9 Cluster: Complex: Sir2p is one of four Silent In...    43   0.006
UniRef50_Q5V4Q5 Cluster: NAD-dependent deacetylase; n=2; Halobac...    43   0.006
UniRef50_Q011Q8 Cluster: NAD-dependent deacetylase SIRT2; n=2; O...    43   0.008
UniRef50_Q6BPH5 Cluster: Debaryomyces hansenii chromosome E of s...    43   0.008
UniRef50_Q0UMU7 Cluster: Putative uncharacterized protein; n=1; ...    43   0.008
UniRef50_O94066 Cluster: Transcription regulatory protein; n=6; ...    43   0.008
UniRef50_Q96EB6 Cluster: NAD-dependent deacetylase sirtuin-1; n=...    43   0.008
UniRef50_Q9UR39 Cluster: NAD-dependent deacetylase hst4; n=1; Sc...    43   0.008
UniRef50_A4J646 Cluster: Silent information regulator protein Si...    42   0.011
UniRef50_A1HU63 Cluster: Silent information regulator protein Si...    42   0.011
UniRef50_A7RMK8 Cluster: Predicted protein; n=5; Eumetazoa|Rep: ...    42   0.011
UniRef50_A0D0F1 Cluster: Chromosome undetermined scaffold_33, wh...    42   0.011
UniRef50_Q6BPA4 Cluster: Debaryomyces hansenii chromosome E of s...    42   0.011
UniRef50_A5DSX8 Cluster: NAD-dependent histone deacetylase SIR2;...    42   0.011
UniRef50_A4RMS1 Cluster: Putative uncharacterized protein; n=2; ...    42   0.011
UniRef50_Q5KPC9 Cluster: Hst3 protein, putative; n=2; Filobasidi...    42   0.015
UniRef50_Q4PG00 Cluster: Putative uncharacterized protein; n=1; ...    42   0.015
UniRef50_A5DNV7 Cluster: Putative uncharacterized protein; n=1; ...    42   0.015
UniRef50_Q9NXA8 Cluster: NAD-dependent deacetylase sirtuin-5; n=...    42   0.015
UniRef50_Q97MB4 Cluster: NAD-dependent deacetylase; n=7; Bacteri...    42   0.015
UniRef50_A6Q2C0 Cluster: Transcriptional regulator, Sir2 family;...    42   0.019
UniRef50_A4JJP4 Cluster: Silent information regulator protein Si...    42   0.019
UniRef50_A3JEV2 Cluster: NAD-dependent deacetylase; n=2; Marinob...    42   0.019
UniRef50_Q4QB33 Cluster: Sir2-family protein-like protein; n=4; ...    42   0.019
UniRef50_Q2H5A0 Cluster: Putative uncharacterized protein; n=1; ...    42   0.019
UniRef50_O94640 Cluster: NAD-dependent histone deacetylase sir2;...    42   0.019
UniRef50_UPI0000E49AD8 Cluster: PREDICTED: similar to NAD-depend...    41   0.025
UniRef50_Q6C219 Cluster: Yarrowia lipolytica chromosome F of str...    41   0.025
UniRef50_A4QUX8 Cluster: Putative uncharacterized protein; n=1; ...    41   0.025
UniRef50_A1ZHW6 Cluster: NAD-dependent deacetylase; n=2; Microsc...    41   0.034
UniRef50_Q7QZ36 Cluster: GLP_464_21655_23334; n=1; Giardia lambl...    41   0.034
UniRef50_Q2HG51 Cluster: Putative uncharacterized protein; n=2; ...    41   0.034
UniRef50_Q899G3 Cluster: NAD-dependent deacetylase; n=19; cellul...    41   0.034
UniRef50_Q81NT6 Cluster: NAD-dependent deacetylase; n=11; Bacill...    41   0.034
UniRef50_UPI0000D578DC Cluster: PREDICTED: similar to sirtuin 5 ...    40   0.044
UniRef50_Q21KQ1 Cluster: Silent information regulator protein Si...    40   0.044
UniRef50_Q046W9 Cluster: NAD-dependent protein deacetylase, SIR2...    40   0.044
UniRef50_A6WG46 Cluster: Silent information regulator protein Si...    40   0.044
UniRef50_Q1EP52 Cluster: Transcriptional regulator Sir2 family p...    40   0.044
UniRef50_Q54QE6 Cluster: Zn finger-containing protein; n=5; Euka...    40   0.044
UniRef50_Q9USN7 Cluster: Sir2 family histone deacetylase Hst2; n...    40   0.044
UniRef50_Q5KG84 Cluster: Hst4 protein, putative; n=2; Filobasidi...    40   0.044
UniRef50_A3LRA1 Cluster: Transcriptional regulatory protein; n=2...    40   0.044
UniRef50_A1CD03 Cluster: SIR2 family histone deacetylase, putati...    40   0.044
UniRef50_Q67KQ0 Cluster: NAD-dependent deacetylase; n=1; Symbiob...    40   0.044
UniRef50_Q607X6 Cluster: NAD-dependent deacetylase; n=1; Methylo...    40   0.044
UniRef50_P53688 Cluster: NAD-dependent histone deacetylase HST4;...    40   0.044
UniRef50_Q3E2I1 Cluster: Silent information regulator protein Si...    40   0.059
UniRef50_Q22ZC3 Cluster: Transcriptional regulator, Sir2 family ...    40   0.059
UniRef50_A4VDQ9 Cluster: Chromatin regulatory protein sir2; n=1;...    40   0.059
UniRef50_A0DQW0 Cluster: Chromosome undetermined scaffold_6, who...    40   0.059
UniRef50_Q6BVM7 Cluster: Similar to CA4170|IPF7784 Candida albic...    40   0.059
UniRef50_Q4WFZ3 Cluster: SIR2 family histone deacetylase, putati...    40   0.059
UniRef50_Q7ZVK3 Cluster: NAD-dependent deacetylase sirtuin-2; n=...    40   0.059
UniRef50_P53687 Cluster: NAD-dependent histone deacetylase HST3;...    40   0.059
UniRef50_UPI00015B48CB Cluster: PREDICTED: similar to 85 kda cal...    40   0.078
UniRef50_UPI000023E2DA Cluster: hypothetical protein FG00460.1; ...    40   0.078
UniRef50_A6LP94 Cluster: Silent information regulator protein Si...    40   0.078
UniRef50_Q23YS7 Cluster: Transcriptional regulator, Sir2 family ...    40   0.078
UniRef50_Q4P3S4 Cluster: Putative uncharacterized protein; n=1; ...    40   0.078
UniRef50_A1CTI6 Cluster: SIR2 family histone deacetylase, putati...    40   0.078
UniRef50_O59923 Cluster: NAD-dependent histone deacetylase SIR2;...    40   0.078
UniRef50_Q8U1Q1 Cluster: NAD-dependent deacetylase; n=19; cellul...    40   0.078
UniRef50_UPI0000519F58 Cluster: PREDICTED: similar to Sirt4 CG31...    39   0.10 
UniRef50_UPI00004997CB Cluster: Sir2 family transcriptional regu...    39   0.10 
UniRef50_A4A980 Cluster: NAD-dependent deacetylase; n=5; Gammapr...    39   0.10 
UniRef50_A1I9S7 Cluster: NAD-dependent deacetylase; n=1; Candida...    39   0.10 
UniRef50_A1FG80 Cluster: Silent information regulator protein Si...    39   0.10 
UniRef50_Q54P49 Cluster: Zn finger-containing protein; n=1; Dict...    39   0.10 
UniRef50_Q298C7 Cluster: GA18650-PA; n=1; Drosophila pseudoobscu...    39   0.10 
UniRef50_Q5KDE0 Cluster: NAD-dependent histone deacetylase, puta...    39   0.10 
UniRef50_P06700 Cluster: NAD-dependent histone deacetylase SIR2;...    39   0.10 
UniRef50_Q885X7 Cluster: NAD-dependent deacetylase 2; n=4; Pseud...    39   0.10 
UniRef50_UPI000050FCF4 Cluster: COG0846: NAD-dependent protein d...    39   0.14 
UniRef50_Q4S7H2 Cluster: Chromosome 13 SCAF14715, whole genome s...    39   0.14 
UniRef50_Q03ZB1 Cluster: NAD-dependent protein deacetylase, SIR2...    39   0.14 
UniRef50_Q8SSB6 Cluster: SIR2-LIKE PROTEIN INVOLVED IN TELOMERIC...    39   0.14 
UniRef50_Q750H1 Cluster: AGL018Cp; n=1; Eremothecium gossypii|Re...    39   0.14 
UniRef50_A5DJ74 Cluster: Putative uncharacterized protein; n=1; ...    39   0.14 
UniRef50_A4RCT8 Cluster: Putative uncharacterized protein; n=3; ...    39   0.14 
UniRef50_Q8R216 Cluster: NAD-dependent deacetylase sirtuin-4; n=...    39   0.14 
UniRef50_Q9Y6E7 Cluster: NAD-dependent deacetylase sirtuin-4; n=...    39   0.14 
UniRef50_A7HID4 Cluster: Silent information regulator protein Si...    38   0.18 
UniRef50_A7H7B6 Cluster: Silent information regulator protein Si...    38   0.18 
UniRef50_A0PU12 Cluster: Sir2-like regulatory protein; n=1; Myco...    38   0.18 
UniRef50_Q8IRR5 Cluster: CG3187-PC, isoform C; n=4; Diptera|Rep:...    38   0.18 
UniRef50_A2DKF0 Cluster: Transcriptional regulator, Sir2 family ...    38   0.18 
UniRef50_Q6CAJ8 Cluster: Similar to sp|P53687 Saccharomyces cere...    38   0.18 
UniRef50_A4QX96 Cluster: Putative uncharacterized protein; n=2; ...    38   0.18 
UniRef50_A3LN35 Cluster: NAD-dependent histone deacetylase SIR2;...    38   0.18 
UniRef50_A2QWZ2 Cluster: Function: human SIRT5 belongs to the Si...    38   0.18 
UniRef50_Q7WLE5 Cluster: NAD-dependent deacetylase; n=47; Bacter...    38   0.18 
UniRef50_UPI00015B4FA0 Cluster: PREDICTED: similar to chromatin ...    38   0.24 
UniRef50_UPI00006CA40C Cluster: transcriptional regulator, Sir2 ...    38   0.24 
UniRef50_Q4QKL5 Cluster: NAD-dependent deacetylase sirtuin 5; n=...    38   0.24 
UniRef50_Q1D737 Cluster: NAD-dependent deacetylase; n=1; Myxococ...    38   0.24 
UniRef50_A6XDL2 Cluster: Sirtuin 1; n=2; Schistosoma|Rep: Sirtui...    38   0.24 
UniRef50_Q8IXJ6 Cluster: NAD-dependent deacetylase sirtuin-2; n=...    38   0.24 
UniRef50_Q6C8C7 Cluster: Similar to DEHA0C01507g Debaryomyces ha...    38   0.31 
UniRef50_A6SP88 Cluster: Putative uncharacterized protein; n=2; ...    38   0.31 
UniRef50_Q9NTG7 Cluster: NAD-dependent deacetylase sirtuin-3, mi...    38   0.31 
UniRef50_UPI0000499DEA Cluster: Sir2 family transcriptional regu...    37   0.41 
UniRef50_A2ABY8 Cluster: Sirtuin 7 (Silent mating type informati...    37   0.41 
UniRef50_Q1RL71 Cluster: Zinc finger protein; n=2; Ciona intesti...    37   0.41 
UniRef50_Q882K4 Cluster: NAD-dependent deacetylase 3; n=5; Pseud...    37   0.41 
UniRef50_Q7PS76 Cluster: ENSANGP00000025231; n=1; Anopheles gamb...    37   0.55 
UniRef50_A2F9H1 Cluster: Transcriptional regulator, Sir2 family ...    37   0.55 
UniRef50_Q89EA6 Cluster: NAD-dependent deacetylase 2; n=9; Prote...    37   0.55 
UniRef50_Q07FY7 Cluster: Sirtuin (Silent mating type information...    36   0.72 
UniRef50_Q62HT8 Cluster: Transcriptional regulator, Sir2 family;...    36   0.72 
UniRef50_A4A8B4 Cluster: Silent information regulator protein Si...    36   0.72 
UniRef50_A1ZZG3 Cluster: NAD-dependent deacetylase; n=35; Bacter...    36   0.72 
UniRef50_A7SK95 Cluster: Predicted protein; n=1; Nematostella ve...    36   0.72 
UniRef50_Q6FKU1 Cluster: Similar to sp|P53686 Saccharomyces cere...    36   0.72 
UniRef50_Q88BY5 Cluster: NAD-dependent deacetylase; n=9; Bacteri...    36   0.72 
UniRef50_Q9I4E1 Cluster: NAD-dependent deacetylase 2; n=6; Pseud...    36   0.72 
UniRef50_Q1D9X2 Cluster: Sir2 family protein; n=1; Myxococcus xa...    36   0.96 
UniRef50_Q6MJJ2 Cluster: NAD-dependent deacetylase; n=5; Proteob...    36   0.96 
UniRef50_Q8FUC8 Cluster: NAD-dependent deacetylase 1; n=6; Coryn...    36   0.96 
UniRef50_UPI00005A356B Cluster: PREDICTED: similar to NAD-depend...    36   1.3  
UniRef50_Q1QTH0 Cluster: Silent information regulator protein Si...    36   1.3  
UniRef50_A0JXS0 Cluster: Silent information regulator protein Si...    36   1.3  
UniRef50_Q4DP02 Cluster: Silent information regulator 2, putativ...    36   1.3  
UniRef50_A2F8N6 Cluster: Transcriptional regulator, Sir2 family ...    36   1.3  
UniRef50_P48324 Cluster: Uncharacterized 24.3 kDa protein in psb...    36   1.3  
UniRef50_Q9RL35 Cluster: NAD-dependent deacetylase 1; n=8; Actin...    36   1.3  
UniRef50_Q9I4L0 Cluster: NAD-dependent deacetylase 1; n=10; Bact...    36   1.3  
UniRef50_Q2U9Y7 Cluster: Sirtuin 4 and related class II sirtuins...    35   1.7  
UniRef50_P53686 Cluster: NAD-dependent deacetylase HST2; n=4; Sa...    35   1.7  
UniRef50_Q6AF12 Cluster: Regulatory protein, Sir2 family; n=2; A...    35   2.2  
UniRef50_Q5P3W1 Cluster: NAD-dependent deacetylase 2; n=4; Prote...    35   2.2  
UniRef50_Q4XD65 Cluster: Putative uncharacterized protein; n=1; ...    35   2.2  
UniRef50_A2DKY5 Cluster: Transcriptional regulator, Sir2 family ...    35   2.2  
UniRef50_A5DW75 Cluster: Putative uncharacterized protein; n=1; ...    35   2.2  
UniRef50_A2QUR5 Cluster: Remark: the H. sapiens SIRT4 belongs to...    35   2.2  
UniRef50_Q8F3Z6 Cluster: NAD-dependent deacetylase; n=4; Leptosp...    35   2.2  
UniRef50_Q4APN6 Cluster: Silent information regulator protein Si...    34   2.9  
UniRef50_A6Q946 Cluster: Transcriptional regulator, Sir2 family;...    34   2.9  
UniRef50_A3WK56 Cluster: SIR2-like regulatory protein, NAD-depen...    34   2.9  
UniRef50_Q54LF0 Cluster: Ankyrin repeat-containing protein; n=1;...    34   2.9  
UniRef50_Q17JQ3 Cluster: Mitochondrial ribosomal protein, S34, p...    34   2.9  
UniRef50_Q7S223 Cluster: Putative uncharacterized protein NCU059...    34   2.9  
UniRef50_Q2KH01 Cluster: Putative uncharacterized protein; n=2; ...    34   2.9  
UniRef50_Q25337 Cluster: NAD-dependent deacetylase SIR2 homolog;...    34   2.9  
UniRef50_Q839C6 Cluster: NAD-dependent deacetylase; n=14; Bacill...    34   2.9  
UniRef50_Q8A3H9 Cluster: NAD-dependent deacetylase; n=3; Bactero...    34   2.9  
UniRef50_A6FYM4 Cluster: Sir2 family protein; n=1; Plesiocystis ...    34   3.9  
UniRef50_A5K7T7 Cluster: NAD-dependent deacetylase, putative; n=...    34   3.9  
UniRef50_Q8ZFR1 Cluster: NAD-dependent deacetylase; n=149; cellu...    34   3.9  
UniRef50_O25849 Cluster: NAD-dependent deacetylase; n=11; Bacter...    34   3.9  
UniRef50_A5WD15 Cluster: Silent information regulator protein Si...    33   5.1  
UniRef50_Q1RPU9 Cluster: Zinc finger protein; n=1; Ciona intesti...    33   5.1  
UniRef50_UPI0000E47C29 Cluster: PREDICTED: similar to dermatan/c...    33   6.7  
UniRef50_UPI000023DCB3 Cluster: hypothetical protein FG05505.1; ...    33   6.7  
UniRef50_A0Z2E4 Cluster: NAD-dependent deacetylase; n=1; marine ...    33   6.7  
UniRef50_Q7QZ37 Cluster: GLP_464_19573_21615; n=1; Giardia lambl...    33   6.7  
UniRef50_Q4RXH1 Cluster: Chromosome 11 SCAF14979, whole genome s...    33   8.9  
UniRef50_Q7MVT1 Cluster: Ribonuclease BN, putative; n=1; Porphyr...    33   8.9  
UniRef50_A0RQP1 Cluster: General glycosylation pathway protein; ...    33   8.9  
UniRef50_A0C6J0 Cluster: Chromosome undetermined scaffold_152, w...    33   8.9  
UniRef50_Q4WET3 Cluster: SIR2 family histone deacetylase, putati...    33   8.9  

>UniRef50_Q9VH08 Cluster: CG6284-PA; n=9; Eumetazoa|Rep: CG6284-PA -
           Drosophila melanogaster (Fruit fly)
          Length = 317

 Score =  132 bits (319), Expect = 8e-30
 Identities = 58/86 (67%), Positives = 72/86 (83%)
 Frame = +2

Query: 257 GLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGP 436
           GLS Y+NKGILG PE FDS++ + +KC  LA+L+K S H+V+HTGAGISTSAGIPDFRGP
Sbjct: 8   GLSAYDNKGILGAPESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGP 67

Query: 437 NGVWTLEKEGKKPTINVSFADAQPQK 514
            GVWTLE++G+KP  NVSF +A+P K
Sbjct: 68  KGVWTLEEKGEKPDFNVSFDEARPTK 93


>UniRef50_Q8N6T7-2 Cluster: Isoform 2 of Q8N6T7 ; n=5;
           Catarrhini|Rep: Isoform 2 of Q8N6T7 - Homo sapiens
           (Human)
          Length = 328

 Score =  101 bits (243), Expect = 1e-20
 Identities = 46/84 (54%), Positives = 61/84 (72%)
 Frame = +2

Query: 257 GLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGP 436
           GLSPY +KG  G+PE FD  ++L +K   LA+LV  S  +V HTGAGIST++GIPDFRGP
Sbjct: 8   GLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGP 67

Query: 437 NGVWTLEKEGKKPTINVSFADAQP 508
           +GVWT+E+ G  P  + +F  A+P
Sbjct: 68  HGVWTMEERGLAPKFDTTFESARP 91


>UniRef50_Q8N6T7 Cluster: Mono-ADP-ribosyltransferase sirtuin-6;
           n=22; Euteleostomi|Rep: Mono-ADP-ribosyltransferase
           sirtuin-6 - Homo sapiens (Human)
          Length = 355

 Score =  101 bits (243), Expect = 1e-20
 Identities = 46/84 (54%), Positives = 61/84 (72%)
 Frame = +2

Query: 257 GLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGP 436
           GLSPY +KG  G+PE FD  ++L +K   LA+LV  S  +V HTGAGIST++GIPDFRGP
Sbjct: 8   GLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGP 67

Query: 437 NGVWTLEKEGKKPTINVSFADAQP 508
           +GVWT+E+ G  P  + +F  A+P
Sbjct: 68  HGVWTMEERGLAPKFDTTFESARP 91


>UniRef50_Q9FE17 Cluster: Sir2-like protein; n=9; Magnoliophyta|Rep:
           Sir2-like protein - Arabidopsis thaliana (Mouse-ear
           cress)
          Length = 473

 Score = 89.0 bits (211), Expect = 1e-16
 Identities = 45/84 (53%), Positives = 58/84 (69%), Gaps = 1/84 (1%)
 Frame = +2

Query: 260 LSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPN 439
           LS  E+ G +G+ E FD +  L  K   LA+L++ SKH+VV TGAGISTS GIPDFRGP 
Sbjct: 9   LSFIEDVGQVGMAEFFDPSHLLQCKIEELAKLIQKSKHLVVFTGAGISTSCGIPDFRGPK 68

Query: 440 GVWTLEKEGKK-PTINVSFADAQP 508
           G+WTL++EGK  P  ++ F  A P
Sbjct: 69  GIWTLQREGKDLPKASLPFHRAMP 92


>UniRef50_Q7SB01 Cluster: Putative uncharacterized protein
           NCU07624.1; n=1; Neurospora crassa|Rep: Putative
           uncharacterized protein NCU07624.1 - Neurospora crassa
          Length = 437

 Score = 80.6 bits (190), Expect = 3e-14
 Identities = 38/73 (52%), Positives = 52/73 (71%), Gaps = 1/73 (1%)
 Frame = +2

Query: 299 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPT 478
           E F++ + +++K  +LA L++ SKH VV TGAG+STSAGIPDFRGP GVWTL  +G++ T
Sbjct: 12  EMFEAPEVIDRKAKVLADLIRKSKHFVVFTGAGVSTSAGIPDFRGPEGVWTLMAQGRQAT 71

Query: 479 -INVSFADAQPQK 514
             +V    A P K
Sbjct: 72  KKSVDVLQAIPTK 84


>UniRef50_Q4UH74 Cluster: Sir2-like histone deacetylase, putative;
           n=2; Theileria|Rep: Sir2-like histone deacetylase,
           putative - Theileria annulata
          Length = 928

 Score = 77.8 bits (183), Expect = 2e-13
 Identities = 32/65 (49%), Positives = 47/65 (72%)
 Frame = +2

Query: 260 LSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPN 439
           L    NKG LG+ E FD+N ++ +K  LL + +  S + ++HTGAG+ST +GIPDFRGP+
Sbjct: 12  LKKNNNKGPLGLDELFDTNKQVTKKVNLLYEYLSKSNNTIIHTGAGVSTGSGIPDFRGPS 71

Query: 440 GVWTL 454
           G+WT+
Sbjct: 72  GIWTV 76


>UniRef50_A5K3P4 Cluster: Putative uncharacterized protein; n=1;
           Plasmodium vivax|Rep: Putative uncharacterized protein -
           Plasmodium vivax
          Length = 1259

 Score = 77.8 bits (183), Expect = 2e-13
 Identities = 35/72 (48%), Positives = 49/72 (68%)
 Frame = +2

Query: 242 LQLCKGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIP 421
           +   + LS  ENKG LG  E F+ +++  +K   L + ++ S+HIVVH GAGISTS+G+ 
Sbjct: 4   MNYARRLSKNENKGPLGEKEYFEDSEEEKRKIKKLIEKIRTSEHIVVHAGAGISTSSGLQ 63

Query: 422 DFRGPNGVWTLE 457
           DFRGP G+WT E
Sbjct: 64  DFRGPTGIWTNE 75


>UniRef50_A5AF92 Cluster: Putative uncharacterized protein; n=1;
           Vitis vinifera|Rep: Putative uncharacterized protein -
           Vitis vinifera (Grape)
          Length = 343

 Score = 77.0 bits (181), Expect = 4e-13
 Identities = 35/63 (55%), Positives = 47/63 (74%), Gaps = 1/63 (1%)
 Frame = +2

Query: 323 LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKK-PTINVSFAD 499
           +++K   LA +++ SKH+VV TGAGISTS GIPDFRGP G+WTL++EGK  P  ++ F  
Sbjct: 61  MHKKIERLAVMLRKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQREGKALPQASLPFHR 120

Query: 500 AQP 508
           A P
Sbjct: 121 AMP 123


>UniRef50_Q7RP35 Cluster: Sir2-like protein; n=5; Plasmodium
           (Vinckeia)|Rep: Sir2-like protein - Plasmodium yoelii
           yoelii
          Length = 1159

 Score = 76.6 bits (180), Expect = 6e-13
 Identities = 34/66 (51%), Positives = 48/66 (72%)
 Frame = +2

Query: 260 LSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPN 439
           LS  ENKG LG  E F+  ++  +K  +L + ++ S++IVVH+GAGISTS+G+ DFRGP 
Sbjct: 10  LSKNENKGPLGEKEYFEDEEEEKEKIKVLIEKIRTSEYIVVHSGAGISTSSGLQDFRGPT 69

Query: 440 GVWTLE 457
           G+WT E
Sbjct: 70  GIWTNE 75


>UniRef50_UPI0000D573CE Cluster: PREDICTED: similar to CG11305-PA;
           n=1; Tribolium castaneum|Rep: PREDICTED: similar to
           CG11305-PA - Tribolium castaneum
          Length = 627

 Score = 74.5 bits (175), Expect = 2e-12
 Identities = 31/58 (53%), Positives = 47/58 (81%), Gaps = 1/58 (1%)
 Frame = +2

Query: 299 EKFDSNDK-LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK 469
           E+F+   + L +KC++LAQ +  ++H+VV+TGAGIST+A IPD+RGPNG+WT  ++GK
Sbjct: 96  EEFEEPPEVLKEKCLILAQAIAQAQHLVVYTGAGISTAAKIPDYRGPNGIWTRLQQGK 153


>UniRef50_Q1MT39 Cluster: Novel protein similar to vertebratesirtuin
           (Silent mating type information regulation 2 homolog) 7;
           n=2; Danio rerio|Rep: Novel protein similar to
           vertebratesirtuin (Silent mating type information
           regulation 2 homolog) 7 - Danio rerio (Zebrafish)
           (Brachydanio rerio)
          Length = 376

 Score = 72.9 bits (171), Expect = 7e-12
 Identities = 33/70 (47%), Positives = 49/70 (70%)
 Frame = +2

Query: 299 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPT 478
           E FD  + L  K   LA+ V+ +KH+V++TGAGIST+A IPD+RGPNGVWT  ++G+  +
Sbjct: 74  EVFDDAENLKTKVKQLAEAVQRAKHLVIYTGAGISTAASIPDYRGPNGVWTQLQKGRSVS 133

Query: 479 INVSFADAQP 508
            +   + A+P
Sbjct: 134 TS-DLSQAEP 142


>UniRef50_A7AWG1 Cluster: Transcriptional regulator, Sir2 family
           domain containing protein; n=2; Babesia bovis|Rep:
           Transcriptional regulator, Sir2 family domain containing
           protein - Babesia bovis
          Length = 656

 Score = 72.9 bits (171), Expect = 7e-12
 Identities = 32/73 (43%), Positives = 51/73 (69%)
 Frame = +2

Query: 236 NVLQLCKGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAG 415
           + L+    L P +NKG  G  + FD+   +++K     +L+  +K++V+H+GAG+ST+AG
Sbjct: 4   SALKYANQLRPNDNKGPCGGVQLFDNPADISKKFKQTVELLTRAKNVVLHSGAGMSTAAG 63

Query: 416 IPDFRGPNGVWTL 454
           IPDFRGP+GVWT+
Sbjct: 64  IPDFRGPSGVWTV 76


>UniRef50_Q8N6T7-3 Cluster: Isoform 3 of Q8N6T7 ; n=2;
           Catarrhini|Rep: Isoform 3 of Q8N6T7 - Homo sapiens
           (Human)
          Length = 187

 Score = 71.3 bits (167), Expect = 2e-11
 Identities = 34/58 (58%), Positives = 43/58 (74%)
 Frame = +2

Query: 257 GLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFR 430
           GLSPY +KG  G+PE FD  ++L +K   LA+LV  S  +V HTGAGIST++GIPDFR
Sbjct: 8   GLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFR 65


>UniRef50_Q8IKW2 Cluster: Putative uncharacterized protein; n=1;
           Plasmodium falciparum 3D7|Rep: Putative uncharacterized
           protein - Plasmodium falciparum (isolate 3D7)
          Length = 1304

 Score = 71.3 bits (167), Expect = 2e-11
 Identities = 33/66 (50%), Positives = 46/66 (69%)
 Frame = +2

Query: 260 LSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPN 439
           LS  E KG LG  E F+  ++  +K   L + ++ S++IVVH+GAGISTS+G+ DFRGP 
Sbjct: 10  LSKNEYKGPLGEEEFFEDTEEEKKKVKELIEKIRSSEYIVVHSGAGISTSSGLQDFRGPT 69

Query: 440 GVWTLE 457
           G+WT E
Sbjct: 70  GIWTNE 75


>UniRef50_Q9NRC8 Cluster: NAD-dependent deacetylase sirtuin-7; n=24;
           Eumetazoa|Rep: NAD-dependent deacetylase sirtuin-7 -
           Homo sapiens (Human)
          Length = 400

 Score = 71.3 bits (167), Expect = 2e-11
 Identities = 36/73 (49%), Positives = 51/73 (69%)
 Frame = +2

Query: 299 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPT 478
           E  D  ++L  K   LA  V+++K++VV+TGAGIST+A IPD+RGPNGVWTL ++G+   
Sbjct: 77  EVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGR--- 133

Query: 479 INVSFADAQPQKP 517
            +VS AD    +P
Sbjct: 134 -SVSAADLSEAEP 145


>UniRef50_Q175I4 Cluster: Chromatin regulatory protein sir2; n=3;
           Coelomata|Rep: Chromatin regulatory protein sir2 - Aedes
           aegypti (Yellowfever mosquito)
          Length = 720

 Score = 68.5 bits (160), Expect = 1e-10
 Identities = 30/57 (52%), Positives = 41/57 (71%)
 Frame = +2

Query: 299 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK 469
           EK D  +++  K + LAQ +  S H++V+TGAGISTSA IPD+RG  G+WTL  +GK
Sbjct: 58  EKEDEPEEIETKALRLAQAIARSNHLMVYTGAGISTSAKIPDYRGSQGIWTLLAQGK 114


>UniRef50_UPI00015B56BB Cluster: PREDICTED: similar to
           ENSANGP00000025716; n=1; Nasonia vitripennis|Rep:
           PREDICTED: similar to ENSANGP00000025716 - Nasonia
           vitripennis
          Length = 581

 Score = 64.1 bits (149), Expect = 3e-09
 Identities = 27/54 (50%), Positives = 39/54 (72%)
 Frame = +2

Query: 308 DSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK 469
           D+ + L +KC+ LA  +  +  + V+TGAGIST+A IPD+RG NGVWT  ++GK
Sbjct: 91  DAPEILEEKCIRLAAAISRATSLAVYTGAGISTAASIPDYRGTNGVWTRLQQGK 144


>UniRef50_Q9VAQ1 Cluster: CG11305-PA; n=8; Coelomata|Rep: CG11305-PA
           - Drosophila melanogaster (Fruit fly)
          Length = 771

 Score = 61.7 bits (143), Expect = 2e-08
 Identities = 27/59 (45%), Positives = 41/59 (69%)
 Frame = +2

Query: 293 VPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK 469
           V E+ D+   +  K   LA ++  +KH+V +TGAGIST+A IPD+RG  G+WTL ++G+
Sbjct: 99  VVEREDAPHVIEAKVEQLANIISQAKHLVCYTGAGISTAALIPDYRGSQGIWTLLQKGQ 157


>UniRef50_Q29QS4 Cluster: IP11347p; n=1; Drosophila
           melanogaster|Rep: IP11347p - Drosophila melanogaster
           (Fruit fly)
          Length = 98

 Score = 61.3 bits (142), Expect = 2e-08
 Identities = 27/42 (64%), Positives = 32/42 (76%)
 Frame = -2

Query: 507 GCASANDTLMVGFLPSFSKVHTPFGPLKSGIPAEVLMPAPVW 382
           G AS+ +TL  GF P  S+V TP GP KSGIPA+VL+PAPVW
Sbjct: 9   GLASSKETLKSGFSPFSSRVQTPLGPRKSGIPADVLIPAPVW 50


>UniRef50_UPI000049979A Cluster: Sir2 family transcriptional
           regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
           Sir2 family transcriptional regulator - Entamoeba
           histolytica HM-1:IMSS
          Length = 319

 Score = 57.2 bits (132), Expect = 4e-07
 Identities = 25/46 (54%), Positives = 33/46 (71%)
 Frame = +2

Query: 311 SNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           S +++   C  LA+++  SK +VV TGAGIS SAGIPDFR  NG+W
Sbjct: 9   SEEEIEFSCKSLARIISRSKRLVVLTGAGISVSAGIPDFRSRNGMW 54


>UniRef50_Q22KA8 Cluster: Transcriptional regulator, Sir2 family
           protein; n=3; Tetrahymena thermophila SB210|Rep:
           Transcriptional regulator, Sir2 family protein -
           Tetrahymena thermophila SB210
          Length = 386

 Score = 56.0 bits (129), Expect = 8e-07
 Identities = 31/56 (55%), Positives = 36/56 (64%)
 Frame = +2

Query: 299 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEG 466
           E FDS + L  K   LA ++K S H V  TGAGISTSAGI DFR  +GV T+ K G
Sbjct: 13  EYFDSPELLEAKVTQLADMIKQSNHFVCFTGAGISTSAGIADFR--SGVNTVLKTG 66


>UniRef50_Q3F1F4 Cluster: SIR2 family protein; n=1; Bacillus
           thuringiensis serovar israelensis ATCC 35646|Rep: SIR2
           family protein - Bacillus thuringiensis serovar
           israelensis ATCC 35646
          Length = 241

 Score = 54.8 bits (126), Expect = 2e-06
 Identities = 25/43 (58%), Positives = 32/43 (74%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKP 475
           A+L+K S HIVV TGAGIST +G+PD+R   G+W    +GKKP
Sbjct: 6   AELIKKSNHIVVLTGAGISTDSGLPDYRSNGGLW----DGKKP 44


>UniRef50_A6DC77 Cluster: Silent information regulator protein Sir2;
           n=1; Caminibacter mediatlanticus TB-2|Rep: Silent
           information regulator protein Sir2 - Caminibacter
           mediatlanticus TB-2
          Length = 243

 Score = 54.8 bits (126), Expect = 2e-06
 Identities = 21/35 (60%), Positives = 29/35 (82%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           A+++KDSK++V  TGAGIS  +GIP FRGP G+W+
Sbjct: 8   AEIIKDSKNLVAFTGAGISVESGIPTFRGPTGLWS 42


>UniRef50_A4M603 Cluster: Silent information regulator protein Sir2;
           n=1; Petrotoga mobilis SJ95|Rep: Silent information
           regulator protein Sir2 - Petrotoga mobilis SJ95
          Length = 256

 Score = 52.8 bits (121), Expect = 8e-06
 Identities = 22/35 (62%), Positives = 30/35 (85%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           A+L+ +S  I V +GAG+ST+AGIPDFRGPNG++T
Sbjct: 9   AELIYNSNSIAVLSGAGMSTNAGIPDFRGPNGIYT 43


>UniRef50_Q974M6 Cluster: NAD-dependent deacetylase; n=8;
           Thermoprotei|Rep: NAD-dependent deacetylase - Sulfolobus
           tokodaii
          Length = 250

 Score = 52.8 bits (121), Expect = 8e-06
 Identities = 21/39 (53%), Positives = 29/39 (74%)
 Frame = +2

Query: 332 KCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +C  +  L+  S + +  TGAGIST++GIPDFRGPNG+W
Sbjct: 2   ECDKVGDLLLTSTYAIAFTGAGISTASGIPDFRGPNGLW 40


>UniRef50_A3ZMQ7 Cluster: Sir2 family, possible ADP
           ribosyltransferase; n=1; Blastopirellula marina DSM
           3645|Rep: Sir2 family, possible ADP ribosyltransferase -
           Blastopirellula marina DSM 3645
          Length = 252

 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 22/37 (59%), Positives = 29/37 (78%)
 Frame = +2

Query: 341 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           L+A+ + +S+  V+ TGAGIST +GIPDFR P GVWT
Sbjct: 9   LVARWLAESESTVLFTGAGISTESGIPDFRSPGGVWT 45


>UniRef50_Q89LY4 Cluster: NAD-dependent deacetylase 1; n=12;
           Proteobacteria|Rep: NAD-dependent deacetylase 1 -
           Bradyrhizobium japonicum
          Length = 254

 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 21/36 (58%), Positives = 26/36 (72%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           L  ++ ++K IV  TGAGIST  GIPDFR P G+WT
Sbjct: 15  LGDMIAEAKTIVPFTGAGISTECGIPDFRSPGGIWT 50


>UniRef50_Q95Q89 Cluster: Yeast sir related protein 2.4; n=2;
           Caenorhabditis|Rep: Yeast sir related protein 2.4 -
           Caenorhabditis elegans
          Length = 299

 Score = 51.2 bits (117), Expect = 2e-05
 Identities = 26/53 (49%), Positives = 32/53 (60%)
 Frame = +2

Query: 350 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADAQP 508
           Q  +  K I V  GAG+ST + +PDFRG  GVWTL+ EGK     V F  A+P
Sbjct: 50  QAKQTGKPIFVLIGAGVSTGSKLPDFRGKQGVWTLQAEGKHAE-GVDFQVARP 101


>UniRef50_Q8ZT00 Cluster: NAD-dependent deacetylase 2; n=2; cellular
           organisms|Rep: NAD-dependent deacetylase 2 - Pyrobaculum
           aerophilum
          Length = 249

 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 20/35 (57%), Positives = 26/35 (74%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +A L+  S+H VV TGAGIS  +G+P FRGP G+W
Sbjct: 3   VADLLASSRHCVVFTGAGISAESGVPTFRGPGGLW 37


>UniRef50_Q3A6W7 Cluster: NAD-dependent protein deacetylases, SIR2
           family; n=2; Pelobacter|Rep: NAD-dependent protein
           deacetylases, SIR2 family - Pelobacter carbinolicus
           (strain DSM 2380 / Gra Bd 1)
          Length = 278

 Score = 50.4 bits (115), Expect = 4e-05
 Identities = 20/55 (36%), Positives = 36/55 (65%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADAQPQ 511
           A +++ S+ +V  +GAGIST+AGIPDFRGP G++   +   +   ++ +   +P+
Sbjct: 26  ADMIRRSRCVVTLSGAGISTAAGIPDFRGPQGLYVTRRYDPEKVFDIDWFHREPR 80


>UniRef50_Q54GV7 Cluster: NAD(+)-dependent deacetylase, silent
           information regulator protein (Sir2) family protein;
           n=1; Dictyostelium discoideum AX4|Rep: NAD(+)-dependent
           deacetylase, silent information regulator protein (Sir2)
           family protein - Dictyostelium discoideum AX4
          Length = 542

 Score = 50.0 bits (114), Expect = 5e-05
 Identities = 24/45 (53%), Positives = 32/45 (71%), Gaps = 1/45 (2%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKP 475
           + QL + SK+IV+ TGAG+S S GIPDFR   GV+ T+EK+   P
Sbjct: 293 VCQLFESSKNIVIITGAGVSVSCGIPDFRSKGGVYETIEKKYNLP 337


>UniRef50_A7EMW8 Cluster: Putative uncharacterized protein; n=1;
           Sclerotinia sclerotiorum 1980|Rep: Putative
           uncharacterized protein - Sclerotinia sclerotiorum 1980
          Length = 533

 Score = 49.6 bits (113), Expect = 7e-05
 Identities = 24/39 (61%), Positives = 30/39 (76%), Gaps = 1/39 (2%)
 Frame = +2

Query: 353 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-LEKEG 466
           L+K++K I+V TGAGISTS GIPDFR  NG++  LE  G
Sbjct: 203 LIKNAKKIIVITGAGISTSLGIPDFRSANGLYAQLEDTG 241


>UniRef50_UPI00006CB0CC Cluster: transcriptional regulator, Sir2
           family protein; n=1; Tetrahymena thermophila SB210|Rep:
           transcriptional regulator, Sir2 family protein -
           Tetrahymena thermophila SB210
          Length = 442

 Score = 49.2 bits (112), Expect = 1e-04
 Identities = 29/74 (39%), Positives = 44/74 (59%), Gaps = 8/74 (10%)
 Frame = +2

Query: 275 NKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFR-GPN---- 439
           N  +    E  DS ++++ K   L +L++ SK+ V+ TGAG+ST++GIPD+R G N    
Sbjct: 38  NPRLKDTQEHQDSPEQIDTKVNQLIELLQKSKNAVILTGAGVSTASGIPDYRSGANTILK 97

Query: 440 ---GVWTLEKEGKK 472
              G W LE+  KK
Sbjct: 98  TGPGKWELEENKKK 111


>UniRef50_UPI000049971A Cluster: Sir2 family transcriptional
           regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
           Sir2 family transcriptional regulator - Entamoeba
           histolytica HM-1:IMSS
          Length = 285

 Score = 49.2 bits (112), Expect = 1e-04
 Identities = 20/45 (44%), Positives = 32/45 (71%)
 Frame = +2

Query: 314 NDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +D ++    ++A+ ++ SK++ V TGAGIS  +GIPDFR  NG+W
Sbjct: 18  DDSIDIDIEMIARSMEKSKNVTVLTGAGISVESGIPDFRSSNGLW 62


>UniRef50_Q5YR82 Cluster: Putative Sir2 family regulator; n=1;
           Nocardia farcinica|Rep: Putative Sir2 family regulator -
           Nocardia farcinica
          Length = 248

 Score = 49.2 bits (112), Expect = 1e-04
 Identities = 22/29 (75%), Positives = 23/29 (79%)
 Frame = +2

Query: 365 SKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           S  I V TGAGIST +GIPDFRGP GVWT
Sbjct: 9   SGRIGVLTGAGISTDSGIPDFRGPRGVWT 37


>UniRef50_Q0AY57 Cluster: Regulatory protein, sir2 family; n=1;
           Syntrophomonas wolfei subsp. wolfei str. Goettingen|Rep:
           Regulatory protein, sir2 family - Syntrophomonas wolfei
           subsp. wolfei (strain Goettingen)
          Length = 253

 Score = 49.2 bits (112), Expect = 1e-04
 Identities = 25/56 (44%), Positives = 34/56 (60%), Gaps = 1/56 (1%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK-KPTINVSFADAQP 508
           + +++  S + VV TGAGIST AGIPDFRGP G++    E +    IN+ F    P
Sbjct: 8   VVEILDRSHNTVVVTGAGISTEAGIPDFRGPEGIYRKLGENRVMKIINIDFFRNNP 63


>UniRef50_UPI00015B57C0 Cluster: PREDICTED: similar to GA18743-PA;
           n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
           GA18743-PA - Nasonia vitripennis
          Length = 871

 Score = 48.8 bits (111), Expect = 1e-04
 Identities = 19/36 (52%), Positives = 30/36 (83%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           + +L+K+SK+I+V TGAG+S S GIPDFR  +G+++
Sbjct: 197 VVELIKNSKNIIVLTGAGVSVSCGIPDFRSRDGIYS 232


>UniRef50_Q9WYW0 Cluster: NAD-dependent deacetylase; n=4;
           Thermotoga|Rep: NAD-dependent deacetylase - Thermotoga
           maritima
          Length = 246

 Score = 48.8 bits (111), Expect = 1e-04
 Identities = 23/54 (42%), Positives = 36/54 (66%)
 Frame = +2

Query: 353 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADAQPQK 514
           L+ +S+  V  TGAGIST +GIPDFRGPNG++   K+  +   ++ F  + P++
Sbjct: 9   LLNESRLTVTLTGAGISTPSGIPDFRGPNGIY---KKYSQNVFDIDFFYSHPEE 59


>UniRef50_Q8ZU41 Cluster: NAD-dependent deacetylase 1; n=3;
           Pyrobaculum|Rep: NAD-dependent deacetylase 1 -
           Pyrobaculum aerophilum
          Length = 254

 Score = 48.8 bits (111), Expect = 1e-04
 Identities = 21/35 (60%), Positives = 26/35 (74%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +A L+  S   V  TGAG+ST++GIPDFRGP GVW
Sbjct: 13  VASLIARSSCNVALTGAGVSTASGIPDFRGPQGVW 47


>UniRef50_Q2LSF2 Cluster: Sir2 family of NAD+-dependent deacetylase;
           n=2; Syntrophus aciditrophicus SB|Rep: Sir2 family of
           NAD+-dependent deacetylase - Syntrophus aciditrophicus
           (strain SB)
          Length = 271

 Score = 48.4 bits (110), Expect = 2e-04
 Identities = 20/46 (43%), Positives = 31/46 (67%)
 Frame = +2

Query: 311 SNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           S+ +  +K   +A ++  +  +VV TGAG+ST +GIPDFR P G+W
Sbjct: 7   SDREFMEKIDAVADMIWMAGRVVVFTGAGVSTESGIPDFRSPGGLW 52


>UniRef50_Q8CJM9 Cluster: NAD-dependent deacetylase 2; n=3;
           Actinomycetales|Rep: NAD-dependent deacetylase 2 -
           Streptomyces coelicolor
          Length = 241

 Score = 48.4 bits (110), Expect = 2e-04
 Identities = 17/33 (51%), Positives = 26/33 (78%)
 Frame = +2

Query: 374 IVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKK 472
           + + +GAG+ST +GIPD+RGPNG+W  + E +K
Sbjct: 7   VAILSGAGVSTDSGIPDYRGPNGLWRRDPEAEK 39


>UniRef50_Q2YZT2 Cluster: Putative uncharacterized protein; n=1;
           uncultured delta proteobacterium|Rep: Putative
           uncharacterized protein - uncultured delta
           proteobacterium
          Length = 254

 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 19/34 (55%), Positives = 27/34 (79%)
 Frame = +2

Query: 350 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           Q++K SK+++  TGAGIS  +GIPDFR P G+W+
Sbjct: 11  QMIK-SKYVIAMTGAGISVESGIPDFRSPGGLWS 43


>UniRef50_A7B9E8 Cluster: Putative uncharacterized protein; n=1;
           Actinomyces odontolyticus ATCC 17982|Rep: Putative
           uncharacterized protein - Actinomyces odontolyticus ATCC
           17982
          Length = 251

 Score = 47.6 bits (108), Expect = 3e-04
 Identities = 25/64 (39%), Positives = 35/64 (54%), Gaps = 1/64 (1%)
 Frame = +2

Query: 323 LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTI-NVSFAD 499
           +N     LA  +  S   V   GAG+ST +GIPDFRG NG +  E+E    T+ ++ F +
Sbjct: 1   MNSDVSTLAAWIAASPSTVFFGGAGVSTESGIPDFRGANGFYFQEREIPLETVLSIDFFE 60

Query: 500 AQPQ 511
             PQ
Sbjct: 61  RHPQ 64


>UniRef50_A6RRE3 Cluster: Putative uncharacterized protein; n=1;
           Botryotinia fuckeliana B05.10|Rep: Putative
           uncharacterized protein - Botryotinia fuckeliana B05.10
          Length = 526

 Score = 47.6 bits (108), Expect = 3e-04
 Identities = 20/33 (60%), Positives = 27/33 (81%)
 Frame = +2

Query: 350 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +L++ +K I+V TGAGISTS GIPDFR  NG++
Sbjct: 198 ELIRGAKKIIVITGAGISTSLGIPDFRSANGLY 230


>UniRef50_Q5KZE8 Cluster: NAD-dependent deacetylase 2; n=3;
           Bacteria|Rep: NAD-dependent deacetylase 2 - Geobacillus
           kaustophilus
          Length = 247

 Score = 47.6 bits (108), Expect = 3e-04
 Identities = 21/38 (55%), Positives = 28/38 (73%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLE 457
           LAQ +K++  I V TGAG+ST +GIPDFR  NG++  E
Sbjct: 7   LAQWIKEANTIAVLTGAGMSTESGIPDFRSENGLYAQE 44


>UniRef50_UPI0000E49846 Cluster: PREDICTED: similar to Sirtuin
           (silent mating type information regulation 2 homolog) 6
           (S. cerevisiae); n=1; Strongylocentrotus purpuratus|Rep:
           PREDICTED: similar to Sirtuin (silent mating type
           information regulation 2 homolog) 6 (S. cerevisiae) -
           Strongylocentrotus purpuratus
          Length = 521

 Score = 47.2 bits (107), Expect = 4e-04
 Identities = 19/27 (70%), Positives = 22/27 (81%)
 Frame = +2

Query: 428 RGPNGVWTLEKEGKKPTINVSFADAQP 508
           RGP GVWTLEK+GKKP  NV+F  A+P
Sbjct: 11  RGPKGVWTLEKQGKKPEANVTFDTAKP 37


>UniRef50_Q5KA61 Cluster: Histone deacetylase, putative; n=1;
           Filobasidiella neoformans|Rep: Histone deacetylase,
           putative - Cryptococcus neoformans (Filobasidiella
           neoformans)
          Length = 596

 Score = 47.2 bits (107), Expect = 4e-04
 Identities = 23/40 (57%), Positives = 30/40 (75%), Gaps = 1/40 (2%)
 Frame = +2

Query: 353 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-LEKEGK 469
           L+  SK I+V +GAGISTS GIPDFR   G++  L++EGK
Sbjct: 152 LLAKSKKIIVLSGAGISTSCGIPDFRSSTGLYAQLQEEGK 191


>UniRef50_A6R1B0 Cluster: Predicted protein; n=2; Onygenales|Rep:
           Predicted protein - Ajellomyces capsulatus NAm1
          Length = 547

 Score = 47.2 bits (107), Expect = 4e-04
 Identities = 26/55 (47%), Positives = 35/55 (63%), Gaps = 1/55 (1%)
 Frame = +2

Query: 341 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKPTINVSFADA 502
           LL + ++  + IVV  GAGIS SAGIPDFR  +G++ TL+K+ K  T      DA
Sbjct: 94  LLLKALQKKRKIVVIAGAGISVSAGIPDFRSAHGLFKTLKKDHKLKTSGKQLFDA 148


>UniRef50_A2Q9C4 Cluster: Contig An01c0250, complete genome; n=18;
           Pezizomycotina|Rep: Contig An01c0250, complete genome -
           Aspergillus niger
          Length = 495

 Score = 47.2 bits (107), Expect = 4e-04
 Identities = 25/50 (50%), Positives = 33/50 (66%), Gaps = 2/50 (4%)
 Frame = +2

Query: 287 LGVPEKFDSNDKLNQKCVL--LAQLVKDSKHIVVHTGAGISTSAGIPDFR 430
           + +  +F    KL Q   +    +L+K+SK+IVV TGAGISTS GIPDFR
Sbjct: 150 IAISREFSRRPKLPQYNTIDDAVKLLKESKNIVVLTGAGISTSLGIPDFR 199


>UniRef50_O96505 Cluster: SIR2; n=4; Sophophora|Rep: SIR2 -
           Drosophila melanogaster (Fruit fly)
          Length = 823

 Score = 46.8 bits (106), Expect = 5e-04
 Identities = 20/32 (62%), Positives = 25/32 (78%)
 Frame = +2

Query: 353 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           LVK S+ I+V TGAG+S S GIPDFR  NG++
Sbjct: 215 LVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIY 246


>UniRef50_Q5AQ47 Cluster: Potential Sir2 family histone deacetylase;
           n=2; Candida albicans|Rep: Potential Sir2 family histone
           deacetylase - Candida albicans (Yeast)
          Length = 657

 Score = 46.8 bits (106), Expect = 5e-04
 Identities = 20/35 (57%), Positives = 29/35 (82%)
 Frame = +2

Query: 350 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL 454
           +L+++SK+I+V TGAGISTS GIPDFR   G +++
Sbjct: 296 KLIENSKNIMVITGAGISTSLGIPDFRSSQGFYSM 330


>UniRef50_Q8REC3 Cluster: NAD-dependent deacetylase; n=3;
           Fusobacterium nucleatum|Rep: NAD-dependent deacetylase -
           Fusobacterium nucleatum subsp. nucleatum
          Length = 252

 Score = 46.8 bits (106), Expect = 5e-04
 Identities = 21/55 (38%), Positives = 39/55 (70%), Gaps = 1/55 (1%)
 Frame = +2

Query: 314 NDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKP 475
           + K ++K + L +++K++K++V   GAG ST +G+ DFRG +G++ TL K+  +P
Sbjct: 2   DSKRDEKILELVKILKNTKYLVFFGGAGTSTDSGVKDFRGKDGLYKTLYKDKYRP 56


>UniRef50_Q8R984 Cluster: NAD-dependent deacetylase 2; n=1;
           Thermoanaerobacter tengcongensis|Rep: NAD-dependent
           deacetylase 2 - Thermoanaerobacter tengcongensis
          Length = 250

 Score = 46.8 bits (106), Expect = 5e-04
 Identities = 21/35 (60%), Positives = 27/35 (77%), Gaps = 1/35 (2%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGP-NGVW 448
           A+L+K S+  +V TGAGIST +GIPDFR P  G+W
Sbjct: 14  AELIKSSQKTMVLTGAGISTESGIPDFRSPGTGLW 48


>UniRef50_Q23A43 Cluster: Transcriptional regulator, Sir2 family
           protein; n=2; Tetrahymena thermophila SB210|Rep:
           Transcriptional regulator, Sir2 family protein -
           Tetrahymena thermophila SB210
          Length = 503

 Score = 46.4 bits (105), Expect = 7e-04
 Identities = 22/40 (55%), Positives = 26/40 (65%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEG 466
           AQL KD K +V  TGAGIS ++GIP FRG       EK+G
Sbjct: 118 AQLFKDKKKVVFLTGAGISVASGIPTFRGVGAAPLFEKDG 157


>UniRef50_Q1RPU3 Cluster: Zinc finger protein; n=1; Ciona
           intestinalis|Rep: Zinc finger protein - Ciona
           intestinalis (Transparent sea squirt)
          Length = 737

 Score = 46.4 bits (105), Expect = 7e-04
 Identities = 23/56 (41%), Positives = 36/56 (64%)
 Frame = +2

Query: 284 ILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           I+  P++    D +N     + +L+K SK I+V TGAG+S S GIPDFR  +G+++
Sbjct: 162 IISEPKRRKKLDTVNTLSDAI-RLIKTSKKILVLTGAGVSVSCGIPDFRSRDGIYS 216


>UniRef50_A7DQD6 Cluster: Silent information regulator protein Sir2;
           n=1; Candidatus Nitrosopumilus maritimus SCM1|Rep:
           Silent information regulator protein Sir2 - Candidatus
           Nitrosopumilus maritimus SCM1
          Length = 242

 Score = 46.4 bits (105), Expect = 7e-04
 Identities = 23/48 (47%), Positives = 30/48 (62%)
 Frame = +2

Query: 356 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFAD 499
           VK++K IV  TGAGIS  +GIP FRG +G+W      K  TI+  + D
Sbjct: 11  VKNAKKIVFVTGAGISQESGIPTFRGKDGLWRNYDAMKLATIDAFYDD 58


>UniRef50_Q21921 Cluster: NAD-dependent deacetylase SIR2 homolog;
           n=2; Caenorhabditis|Rep: NAD-dependent deacetylase SIR2
           homolog - Caenorhabditis elegans
          Length = 607

 Score = 46.4 bits (105), Expect = 7e-04
 Identities = 19/33 (57%), Positives = 25/33 (75%)
 Frame = +2

Query: 350 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +L K  KHI+V TGAG+S S GIPDFR  +G++
Sbjct: 140 ELFKTKKHILVLTGAGVSVSCGIPDFRSKDGIY 172


>UniRef50_O07595 Cluster: NAD-dependent deacetylase; n=3;
           Bacillus|Rep: NAD-dependent deacetylase - Bacillus
           subtilis
          Length = 247

 Score = 46.4 bits (105), Expect = 7e-04
 Identities = 18/33 (54%), Positives = 26/33 (78%)
 Frame = +2

Query: 353 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           ++ +++ IVV TGAG+ST +GIPDFR   G+WT
Sbjct: 7   ILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWT 39


>UniRef50_A6TNA0 Cluster: Silent information regulator protein Sir2;
           n=1; Alkaliphilus metalliredigens QYMF|Rep: Silent
           information regulator protein Sir2 - Alkaliphilus
           metalliredigens QYMF
          Length = 249

 Score = 46.0 bits (104), Expect = 9e-04
 Identities = 19/46 (41%), Positives = 28/46 (60%)
 Frame = +2

Query: 311 SNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           + +++    + LA L+K SK  V+ TGAG+ T + IPDFR   G W
Sbjct: 6   NGERMKDGVIKLASLIKKSKDTVILTGAGMDTESNIPDFRSEKGWW 51


>UniRef50_A6G0H3 Cluster: Silent information regulator protein Sir2;
           n=1; Plesiocystis pacifica SIR-1|Rep: Silent information
           regulator protein Sir2 - Plesiocystis pacifica SIR-1
          Length = 288

 Score = 46.0 bits (104), Expect = 9e-04
 Identities = 19/34 (55%), Positives = 24/34 (70%)
 Frame = +2

Query: 374 IVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKP 475
           +VV TGAGIS  +GIP FRGP G WT+  +  +P
Sbjct: 31  VVVTTGAGISAESGIPTFRGPEGYWTVGAKEYRP 64


>UniRef50_A0NQ49 Cluster: Silent information regulator protein Sir2;
           n=1; Stappia aggregata IAM 12614|Rep: Silent information
           regulator protein Sir2 - Stappia aggregata IAM 12614
          Length = 260

 Score = 46.0 bits (104), Expect = 9e-04
 Identities = 18/28 (64%), Positives = 22/28 (78%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           + IV  TGAGIST +GIPDFR P G+W+
Sbjct: 23  RQIVALTGAGISTESGIPDFRSPGGIWS 50


>UniRef50_Q2GZ88 Cluster: Putative uncharacterized protein; n=1;
           Chaetomium globosum|Rep: Putative uncharacterized
           protein - Chaetomium globosum (Soil fungus)
          Length = 895

 Score = 46.0 bits (104), Expect = 9e-04
 Identities = 20/37 (54%), Positives = 29/37 (78%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL 454
           +A  +  S+ +VV TGAGIST++GIPDFR  NG+++L
Sbjct: 17  IANTLWKSRKVVVITGAGISTNSGIPDFRSENGLYSL 53


>UniRef50_A6PTK3 Cluster: Silent information regulator protein Sir2;
           n=1; Victivallis vadensis ATCC BAA-548|Rep: Silent
           information regulator protein Sir2 - Victivallis
           vadensis ATCC BAA-548
          Length = 248

 Score = 45.6 bits (103), Expect = 0.001
 Identities = 21/42 (50%), Positives = 29/42 (69%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK 469
           L Q++++S+  +  TGAGIST +GI DFRG NGV+     GK
Sbjct: 5   LKQMLQESRRTLAFTGAGISTLSGIRDFRGKNGVYLEPWHGK 46


>UniRef50_A5UYK2 Cluster: Silent information regulator protein Sir2;
           n=2; Roseiflexus|Rep: Silent information regulator
           protein Sir2 - Roseiflexus sp. RS-1
          Length = 261

 Score = 45.6 bits (103), Expect = 0.001
 Identities = 20/34 (58%), Positives = 24/34 (70%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           A L+  +   V  TGAGIST +GIPDFRGP+G W
Sbjct: 15  ADLLGRAHSAVAITGAGISTPSGIPDFRGPDGAW 48


>UniRef50_Q5BVF7 Cluster: SJCHGC03105 protein; n=2; Schistosoma
           japonicum|Rep: SJCHGC03105 protein - Schistosoma
           japonicum (Blood fluke)
          Length = 181

 Score = 45.6 bits (103), Expect = 0.001
 Identities = 26/54 (48%), Positives = 35/54 (64%), Gaps = 3/54 (5%)
 Frame = +2

Query: 344 LAQLVKDSK--HIVVHTGAGISTSAGIPDFRGP-NGVWTLEKEGKKPTINVSFA 496
           ++QL++D K   IV   GAGIST+AGIPDFR P +GV+   +E   PT    F+
Sbjct: 52  VSQLIQDGKINKIVTMVGAGISTAAGIPDFRSPSSGVYDNLEEFNLPTPTTIFS 105


>UniRef50_Q12Y78 Cluster: Silent information regulator protein Sir2;
           n=1; Methanococcoides burtonii DSM 6242|Rep: Silent
           information regulator protein Sir2 - Methanococcoides
           burtonii (strain DSM 6242)
          Length = 245

 Score = 45.6 bits (103), Expect = 0.001
 Identities = 20/35 (57%), Positives = 29/35 (82%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           L  L+++S++ VV TGAG+ST +GIPDFRG +GV+
Sbjct: 4   LFSLLENSEYCVVLTGAGVSTFSGIPDFRGRSGVY 38


>UniRef50_Q73KE1 Cluster: NAD-dependent deacetylase; n=1; Treponema
           denticola|Rep: NAD-dependent deacetylase - Treponema
           denticola
          Length = 251

 Score = 45.6 bits (103), Expect = 0.001
 Identities = 23/53 (43%), Positives = 34/53 (64%)
 Frame = +2

Query: 341 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFAD 499
           L +++ K ++H+V  TGAGIST AGI DFRG +G++      K   I+V + D
Sbjct: 11  LFSEITK-ARHLVAFTGAGISTLAGIKDFRGKDGLYKQPNTEKMFDIDVFYRD 62


>UniRef50_A6P1S7 Cluster: Putative uncharacterized protein; n=2;
           Bacteria|Rep: Putative uncharacterized protein -
           Bacteroides capillosus ATCC 29799
          Length = 262

 Score = 45.2 bits (102), Expect = 0.002
 Identities = 22/65 (33%), Positives = 40/65 (61%), Gaps = 1/65 (1%)
 Frame = +2

Query: 323 LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTI-NVSFAD 499
           + +   LL + + +S  IV   GAG+ST +GIPDFR  +G++  + +    TI + +F +
Sbjct: 21  MEENRALLQRWIDESSRIVFFGGAGVSTESGIPDFRSVDGLYNQQYDYPPETILSHTFYE 80

Query: 500 AQPQK 514
           A+P++
Sbjct: 81  ARPEE 85


>UniRef50_A0LG97 Cluster: Silent information regulator protein Sir2;
           n=1; Syntrophobacter fumaroxidans MPOB|Rep: Silent
           information regulator protein Sir2 - Syntrophobacter
           fumaroxidans (strain DSM 10017 / MPOB)
          Length = 248

 Score = 45.2 bits (102), Expect = 0.002
 Identities = 19/35 (54%), Positives = 27/35 (77%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           A+L+  S++ VV TGAGIS  +GIPDFR  +G+W+
Sbjct: 8   AELLLRSRYTVVLTGAGISVESGIPDFRSKDGLWS 42


>UniRef50_Q9FY91 Cluster: SIR2-family protein; n=12;
           Magnoliophyta|Rep: SIR2-family protein - Arabidopsis
           thaliana (Mouse-ear cress)
          Length = 451

 Score = 45.2 bits (102), Expect = 0.002
 Identities = 21/50 (42%), Positives = 30/50 (60%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSF 493
           L +L + S  + + TGAG+ST  GIPD+R PNG ++    G KP  +  F
Sbjct: 161 LYRLFEQSSRLTILTGAGVSTECGIPDYRSPNGAYS---SGFKPITHQEF 207


>UniRef50_A7SX90 Cluster: Predicted protein; n=3; Eumetazoa|Rep:
           Predicted protein - Nematostella vectensis
          Length = 306

 Score = 45.2 bits (102), Expect = 0.002
 Identities = 18/35 (51%), Positives = 27/35 (77%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           + +L+K  K+I+V TGAG+S S GIPDFR  +G++
Sbjct: 62  VVRLIKKCKNIIVLTGAGVSVSCGIPDFRSRDGIY 96


>UniRef50_A7EC18 Cluster: Putative uncharacterized protein; n=1;
           Sclerotinia sclerotiorum 1980|Rep: Putative
           uncharacterized protein - Sclerotinia sclerotiorum 1980
          Length = 446

 Score = 45.2 bits (102), Expect = 0.002
 Identities = 22/33 (66%), Positives = 28/33 (84%), Gaps = 2/33 (6%)
 Frame = +2

Query: 344 LAQLVKD--SKHIVVHTGAGISTSAGIPDFRGP 436
           +A+ +K+  +K+IVV TGAGISTSAGIPDFR P
Sbjct: 27  VAEFIKNGQAKNIVVLTGAGISTSAGIPDFRSP 59


>UniRef50_Q8CNF4 Cluster: NAD-dependent deacetylase; n=17;
           Staphylococcus|Rep: NAD-dependent deacetylase -
           Staphylococcus epidermidis (strain ATCC 12228)
          Length = 246

 Score = 45.2 bits (102), Expect = 0.002
 Identities = 20/45 (44%), Positives = 30/45 (66%), Gaps = 1/45 (2%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKP 475
           L  +V +S  IV  TGAG+S ++GIPDFR   G++  + K+G+ P
Sbjct: 9   LKDIVNNSNQIVFFTGAGVSVASGIPDFRSMGGLYDEISKDGQSP 53


>UniRef50_UPI0000D55B5A Cluster: PREDICTED: similar to CG5216-PA;
           n=1; Tribolium castaneum|Rep: PREDICTED: similar to
           CG5216-PA - Tribolium castaneum
          Length = 722

 Score = 44.8 bits (101), Expect = 0.002
 Identities = 18/35 (51%), Positives = 28/35 (80%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           + +LVK +++I+V TGAG+S S GIPDFR  +G++
Sbjct: 204 VVRLVKGAQNIIVLTGAGVSVSCGIPDFRSRDGIY 238


>UniRef50_UPI000051AA14 Cluster: PREDICTED: similar to NAD-dependent
           deacetylase sirtuin-1 (hSIRT1) (hSIR2) (SIR2-like
           protein 1); n=1; Apis mellifera|Rep: PREDICTED: similar
           to NAD-dependent deacetylase sirtuin-1 (hSIRT1) (hSIR2)
           (SIR2-like protein 1) - Apis mellifera
          Length = 868

 Score = 44.8 bits (101), Expect = 0.002
 Identities = 17/36 (47%), Positives = 28/36 (77%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           + +L+++S  I+V TGAG+S S GIPDFR  +G+++
Sbjct: 196 VVRLIRNSNRIIVLTGAGVSVSCGIPDFRSRDGIYS 231


>UniRef50_Q23E36 Cluster: Transcriptional regulator, Sir2 family
           protein; n=1; Tetrahymena thermophila SB210|Rep:
           Transcriptional regulator, Sir2 family protein -
           Tetrahymena thermophila SB210
          Length = 1348

 Score = 44.8 bits (101), Expect = 0.002
 Identities = 19/31 (61%), Positives = 25/31 (80%)
 Frame = +2

Query: 359 KDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           K   +I+  TGAGISTS+GIPDFR PNG+++
Sbjct: 18  KQINNILFLTGAGISTSSGIPDFRSPNGLYS 48


>UniRef50_A2F8E1 Cluster: Transcriptional regulator, Sir2 family
           protein; n=1; Trichomonas vaginalis G3|Rep:
           Transcriptional regulator, Sir2 family protein -
           Trichomonas vaginalis G3
          Length = 331

 Score = 44.8 bits (101), Expect = 0.002
 Identities = 23/49 (46%), Positives = 32/49 (65%), Gaps = 3/49 (6%)
 Frame = +2

Query: 335 CVLLAQLVKDS--KHIVVHTGAGISTSAGIPDFRGPN-GVWTLEKEGKK 472
           C +LAQ +     K+++V TGAGIST+AGIPDFR P  G++   K   +
Sbjct: 7   CEILAQKIISGNYKNVIVLTGAGISTAAGIPDFRSPAIGIYATLKSASR 55


>UniRef50_Q7S386 Cluster: Putative uncharacterized protein
           NCU04859.1; n=1; Neurospora crassa|Rep: Putative
           uncharacterized protein NCU04859.1 - Neurospora crassa
          Length = 1327

 Score = 44.8 bits (101), Expect = 0.002
 Identities = 19/37 (51%), Positives = 29/37 (78%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL 454
           +A  +  ++ +VV TGAGIST++GIPDFR  NG+++L
Sbjct: 17  IANSLYKARKVVVITGAGISTNSGIPDFRSENGLYSL 53


>UniRef50_Q6CB00 Cluster: Similarities with tr|Q9UR39
           Schizosaccharomyces pombe HST4P; n=1; Yarrowia
           lipolytica|Rep: Similarities with tr|Q9UR39
           Schizosaccharomyces pombe HST4P - Yarrowia lipolytica
           (Candida lipolytica)
          Length = 721

 Score = 44.8 bits (101), Expect = 0.002
 Identities = 27/65 (41%), Positives = 39/65 (60%), Gaps = 2/65 (3%)
 Frame = +2

Query: 314 NDKLNQKCV-LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKPTINV 487
           N  +N+K + LL  +  +S+ +VV TGAGIS  AGIPDFR   G++ +L+ E    T   
Sbjct: 157 NSDINRKDLELLHHVFHNSQRLVVITGAGISVHAGIPDFRSDKGLFVSLKDEYNLKTTGK 216

Query: 488 SFADA 502
           +  DA
Sbjct: 217 ALFDA 221


>UniRef50_Q0CR31 Cluster: NAD-dependent histone deacetylase SIR2;
           n=2; Pezizomycotina|Rep: NAD-dependent histone
           deacetylase SIR2 - Aspergillus terreus (strain NIH 2624)
          Length = 1068

 Score = 44.8 bits (101), Expect = 0.002
 Identities = 24/50 (48%), Positives = 33/50 (66%), Gaps = 2/50 (4%)
 Frame = +2

Query: 287 LGVPEKFDSNDKLNQKCVL--LAQLVKDSKHIVVHTGAGISTSAGIPDFR 430
           + +  +F    KL Q   +    +L+++SK+IVV TGAGISTS GIPDFR
Sbjct: 148 IAISREFSRRPKLPQYNSIDDAVKLLQESKNIVVLTGAGISTSLGIPDFR 197


>UniRef50_A6RSV6 Cluster: Putative uncharacterized protein; n=2;
           Sclerotiniaceae|Rep: Putative uncharacterized protein -
           Botryotinia fuckeliana B05.10
          Length = 1195

 Score = 44.8 bits (101), Expect = 0.002
 Identities = 18/37 (48%), Positives = 29/37 (78%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL 454
           +A ++  S+ +VV TGAGIST+ GIPDFR  +G++++
Sbjct: 17  IADILAKSRKVVVVTGAGISTNVGIPDFRSEHGLYSM 53


>UniRef50_Q0LIC7 Cluster: Silent information regulator protein Sir2;
           n=2; Bacteria|Rep: Silent information regulator protein
           Sir2 - Herpetosiphon aurantiacus ATCC 23779
          Length = 244

 Score = 44.4 bits (100), Expect = 0.003
 Identities = 18/27 (66%), Positives = 23/27 (85%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGPNGVW 448
           ++IVV TGAGIS ++G+  FRGPNGVW
Sbjct: 11  RNIVVLTGAGISVASGVRPFRGPNGVW 37


>UniRef50_A6DES9 Cluster: Transcriptional regulator, Sir2 family
           protein; n=2; Epsilonproteobacteria|Rep: Transcriptional
           regulator, Sir2 family protein - Caminibacter
           mediatlanticus TB-2
          Length = 264

 Score = 44.4 bits (100), Expect = 0.003
 Identities = 18/48 (37%), Positives = 29/48 (60%)
 Frame = +2

Query: 341 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTIN 484
           L A  +K++K++++  GAG+   +G+PDFRG  G W      KK  +N
Sbjct: 6   LAANEIKNAKYLLITAGAGMGVDSGLPDFRGNEGFWRAYPIAKKLGLN 53


>UniRef50_Q6CQA7 Cluster: Kluyveromyces lactis strain NRRL Y-1140
           chromosome D of strain NRRL Y- 1140 of Kluyveromyces
           lactis; n=1; Kluyveromyces lactis|Rep: Kluyveromyces
           lactis strain NRRL Y-1140 chromosome D of strain NRRL Y-
           1140 of Kluyveromyces lactis - Kluyveromyces lactis
           (Yeast) (Candida sphaerica)
          Length = 399

 Score = 44.4 bits (100), Expect = 0.003
 Identities = 21/39 (53%), Positives = 27/39 (69%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEK 460
           L  ++  SK IVV  GAG+S +AGIPDFR  NG++T  K
Sbjct: 105 LTYVLSYSKRIVVVQGAGVSVAAGIPDFRSANGLFTTLK 143


>UniRef50_Q0UNC9 Cluster: Putative uncharacterized protein; n=1;
           Phaeosphaeria nodorum|Rep: Putative uncharacterized
           protein - Phaeosphaeria nodorum (Septoria nodorum)
          Length = 479

 Score = 44.4 bits (100), Expect = 0.003
 Identities = 19/31 (61%), Positives = 26/31 (83%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPN 439
           A+L+++ K+I++ TGAGISTS GIPDFR  N
Sbjct: 167 AKLLRERKNIMIITGAGISTSLGIPDFRSKN 197


>UniRef50_A6RXY5 Cluster: Putative uncharacterized protein; n=2;
           Pezizomycotina|Rep: Putative uncharacterized protein -
           Botryotinia fuckeliana B05.10
          Length = 446

 Score = 44.4 bits (100), Expect = 0.003
 Identities = 20/24 (83%), Positives = 22/24 (91%)
 Frame = +2

Query: 365 SKHIVVHTGAGISTSAGIPDFRGP 436
           +K+IVV TGAGISTSAGIPDFR P
Sbjct: 36  AKNIVVMTGAGISTSAGIPDFRSP 59


>UniRef50_A1DG07 Cluster: SIR2 family histone deacetylase, putative;
           n=3; Trichocomaceae|Rep: SIR2 family histone
           deacetylase, putative - Neosartorya fischeri (strain
           ATCC 1020 / DSM 3700 / NRRL 181)(Aspergillus
           fischerianus (strain ATCC 1020 / DSM 3700 / NRRL 181))
          Length = 425

 Score = 44.4 bits (100), Expect = 0.003
 Identities = 20/27 (74%), Positives = 22/27 (81%)
 Frame = +2

Query: 359 KDSKHIVVHTGAGISTSAGIPDFRGPN 439
           KD + IVV  GAGISTSAGIPDFR P+
Sbjct: 33  KDVRRIVVMVGAGISTSAGIPDFRSPD 59


>UniRef50_Q88ZA0 Cluster: NAD-dependent deacetylase; n=4;
           Lactobacillus|Rep: NAD-dependent deacetylase -
           Lactobacillus plantarum
          Length = 234

 Score = 44.4 bits (100), Expect = 0.003
 Identities = 17/32 (53%), Positives = 26/32 (81%)
 Frame = +2

Query: 356 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           ++ ++HIV  TGAG+ST +GIPD+R  NG++T
Sbjct: 11  LQQAQHIVFMTGAGVSTPSGIPDYRSKNGLYT 42


>UniRef50_UPI000023F1DF Cluster: hypothetical protein FG02466.1;
           n=1; Gibberella zeae PH-1|Rep: hypothetical protein
           FG02466.1 - Gibberella zeae PH-1
          Length = 1569

 Score = 44.0 bits (99), Expect = 0.004
 Identities = 22/34 (64%), Positives = 28/34 (82%)
 Frame = +2

Query: 353 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL 454
           L+K  K IVV TGAGIST++GIPDFR  NG+++L
Sbjct: 638 LLKARKVIVV-TGAGISTNSGIPDFRSENGLYSL 670


>UniRef50_A7HL19 Cluster: Silent information regulator protein Sir2;
           n=1; Fervidobacterium nodosum Rt17-B1|Rep: Silent
           information regulator protein Sir2 - Fervidobacterium
           nodosum Rt17-B1
          Length = 244

 Score = 44.0 bits (99), Expect = 0.004
 Identities = 19/41 (46%), Positives = 28/41 (68%)
 Frame = +2

Query: 329 QKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           ++ + L   +K+SK   V TGAG+S  +GIPDFR  NGV++
Sbjct: 2   EEILTLVSWLKNSKFTTVLTGAGVSVPSGIPDFRSKNGVYS 42


>UniRef50_A4JS80 Cluster: Silent information regulator protein Sir2;
           n=1; Burkholderia vietnamiensis G4|Rep: Silent
           information regulator protein Sir2 - Burkholderia
           vietnamiensis (strain G4 / LMG 22486)
           (Burkholderiacepacia (strain R1808))
          Length = 274

 Score = 44.0 bits (99), Expect = 0.004
 Identities = 17/35 (48%), Positives = 24/35 (68%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           A  + D+  IV+  GAG+S  +G+PDFRG  G+WT
Sbjct: 11  ADWIADADGIVIAAGAGMSVDSGLPDFRGTGGLWT 45


>UniRef50_Q875P9 Cluster: HST1; n=1; Lachancea kluyveri|Rep: HST1 -
           Saccharomyces kluyveri (Yeast) (Saccharomyces
           silvestris)
          Length = 414

 Score = 44.0 bits (99), Expect = 0.004
 Identities = 28/78 (35%), Positives = 41/78 (52%)
 Frame = +2

Query: 218 DKLSPKNVLQLCKGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAG 397
           D L  ++ ++L K L    NK +L    K  +   L       A  +K ++ ++V TGAG
Sbjct: 39  DPLEKRHAVRLIKDLQKAMNK-VLSTRIKLANFHTLEH----FAAKLKTARRVLVLTGAG 93

Query: 398 ISTSAGIPDFRGPNGVWT 451
           ISTS GIPDFR   G ++
Sbjct: 94  ISTSLGIPDFRSSEGFYS 111


>UniRef50_Q7S6G9 Cluster: Putative uncharacterized protein
           NCU04737.1; n=3; Sordariomycetes|Rep: Putative
           uncharacterized protein NCU04737.1 - Neurospora crassa
          Length = 670

 Score = 44.0 bits (99), Expect = 0.004
 Identities = 20/27 (74%), Positives = 24/27 (88%)
 Frame = +2

Query: 350 QLVKDSKHIVVHTGAGISTSAGIPDFR 430
           +L+K SK+I+V TGAGISTS GIPDFR
Sbjct: 201 ELLKRSKNIIVLTGAGISTSLGIPDFR 227


>UniRef50_Q6C8V5 Cluster: Similar to tr|Q9FY91 Arabidopsis thaliana
           SIR2-family protein; n=1; Yarrowia lipolytica|Rep:
           Similar to tr|Q9FY91 Arabidopsis thaliana SIR2-family
           protein - Yarrowia lipolytica (Candida lipolytica)
          Length = 411

 Score = 44.0 bits (99), Expect = 0.004
 Identities = 21/60 (35%), Positives = 38/60 (63%)
 Frame = +2

Query: 359 KDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADAQPQKPI*F*KSW 538
           K++K  ++ TGAGIST++G+PD+RGP G +T      +PT+   F   + ++   + ++W
Sbjct: 46  KNTKTAIL-TGAGISTASGLPDYRGPTGTYT-TNPNHQPTLYHEFVSDEHKRKRYWSRAW 103


>UniRef50_Q4WT50 Cluster: SIR2 family histone deacetylase (Hst4),
           putative; n=7; Trichocomaceae|Rep: SIR2 family histone
           deacetylase (Hst4), putative - Aspergillus fumigatus
           (Sartorya fumigata)
          Length = 614

 Score = 44.0 bits (99), Expect = 0.004
 Identities = 22/42 (52%), Positives = 32/42 (76%), Gaps = 1/42 (2%)
 Frame = +2

Query: 341 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKE 463
           LL + ++  + IVV  GAGISTSAGIPDFR  +G++ +L+K+
Sbjct: 125 LLVKTLRRHRKIVVIAGAGISTSAGIPDFRSTDGLFKSLQKK 166


>UniRef50_Q5L014 Cluster: NAD-dependent deacetylase 1; n=7;
           Bacillaceae|Rep: NAD-dependent deacetylase 1 -
           Geobacillus kaustophilus
          Length = 242

 Score = 44.0 bits (99), Expect = 0.004
 Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
 Frame = +2

Query: 365 SKHIVVHTGAGISTSAGIPDFRGP-NGVWTLEKEGKKPTINVSF 493
           S+H VV TGAG+ST +G+PDFR P  G+W      +  TI+  +
Sbjct: 10  SRHTVVLTGAGMSTESGLPDFRSPRTGLWARFNPSELATIDALY 53


>UniRef50_A1ZPG8 Cluster: NAD-dependent deacetylase; n=1;
           Microscilla marina ATCC 23134|Rep: NAD-dependent
           deacetylase - Microscilla marina ATCC 23134
          Length = 278

 Score = 43.6 bits (98), Expect = 0.005
 Identities = 19/46 (41%), Positives = 26/46 (56%)
 Frame = +2

Query: 338 VLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKP 475
           +L AQ +   K I   TGAGIS  +G+P +RG +G+W       KP
Sbjct: 10  LLCAQALAQDKLITFLTGAGISAESGVPTYRGTDGIWVEGSRNYKP 55


>UniRef50_Q7SCL4 Cluster: Putative uncharacterized protein NCU00523.1;
            n=2; Pezizomycotina|Rep: Putative uncharacterized protein
            NCU00523.1 - Neurospora crassa
          Length = 1220

 Score = 43.6 bits (98), Expect = 0.005
 Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 7/83 (8%)
 Frame = +2

Query: 284  ILGVPEKFDSNDKLNQKCVLLAQLVKDSK--HIVVHTGAGISTSAGIPDFRGP-NGVW-- 448
            +  VPE     +   +    +A  +K  K   +VV TGAGIST+AGIPDFR P  G++  
Sbjct: 848  VSAVPETTKPENLSERSLPAVADYIKSGKARKVVVLTGAGISTAAGIPDFRSPETGLYAN 907

Query: 449  --TLEKEGKKPTINVSFADAQPQ 511
               LE E  +   ++ F    P+
Sbjct: 908  LAALELEEPEDVFSLPFFKENPK 930


>UniRef50_A1HLU5 Cluster: Silent information regulator protein Sir2;
           n=1; Thermosinus carboxydivorans Nor1|Rep: Silent
           information regulator protein Sir2 - Thermosinus
           carboxydivorans Nor1
          Length = 261

 Score = 43.2 bits (97), Expect = 0.006
 Identities = 17/35 (48%), Positives = 25/35 (71%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +A   + + +IVV TGAG+ST +G+PDFR   G+W
Sbjct: 9   IAAAWRSANNIVVFTGAGMSTESGLPDFRSKQGLW 43


>UniRef50_A7TQE2 Cluster: Putative uncharacterized protein; n=1;
           Vanderwaltozyma polyspora DSM 70294|Rep: Putative
           uncharacterized protein - Vanderwaltozyma polyspora DSM
           70294
          Length = 602

 Score = 43.2 bits (97), Expect = 0.006
 Identities = 19/32 (59%), Positives = 24/32 (75%)
 Frame = +2

Query: 356 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           +K +K I+V TGAGISTS GIPDFR   G ++
Sbjct: 263 LKSAKKIIVLTGAGISTSLGIPDFRSSEGFYS 294


>UniRef50_A2QFF9 Cluster: Complex: Sir2p is one of four Silent
           Information Regulator genes in yeast. Sir2p; n=6;
           Pezizomycotina|Rep: Complex: Sir2p is one of four Silent
           Information Regulator genes in yeast. Sir2p -
           Aspergillus niger
          Length = 378

 Score = 43.2 bits (97), Expect = 0.006
 Identities = 24/56 (42%), Positives = 34/56 (60%), Gaps = 5/56 (8%)
 Frame = +2

Query: 359 KDSKHIVVHTGAGISTSAGIPDFRGPN-GVWT----LEKEGKKPTINVSFADAQPQ 511
           K  K +VV  GAGISTSAGIPDFR P+ G+++    L+    +   ++SF    P+
Sbjct: 33  KPVKRVVVMVGAGISTSAGIPDFRSPDTGIYSNLAHLDLPDPEAVFDISFFRQNPR 88


>UniRef50_Q5V4Q5 Cluster: NAD-dependent deacetylase; n=2;
           Halobacteriaceae|Rep: NAD-dependent deacetylase -
           Haloarcula marismortui (Halobacterium marismortui)
          Length = 260

 Score = 43.2 bits (97), Expect = 0.006
 Identities = 16/35 (45%), Positives = 27/35 (77%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +A+ ++ ++  V  TGAG+ST++GIP FRG +G+W
Sbjct: 19  VAEALRTAETAVALTGAGVSTASGIPSFRGDDGIW 53


>UniRef50_Q011Q8 Cluster: NAD-dependent deacetylase SIRT2; n=2;
           Ostreococcus|Rep: NAD-dependent deacetylase SIRT2 -
           Ostreococcus tauri
          Length = 394

 Score = 42.7 bits (96), Expect = 0.008
 Identities = 18/28 (64%), Positives = 24/28 (85%)
 Frame = +2

Query: 365 SKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +K++VV TGAGIS SAGIPDFR  +G++
Sbjct: 103 AKNVVVMTGAGISVSAGIPDFRSESGLY 130


>UniRef50_Q6BPH5 Cluster: Debaryomyces hansenii chromosome E of
           strain CBS767 of Debaryomyces hansenii; n=2;
           Saccharomycetaceae|Rep: Debaryomyces hansenii chromosome
           E of strain CBS767 of Debaryomyces hansenii -
           Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
          Length = 573

 Score = 42.7 bits (96), Expect = 0.008
 Identities = 19/32 (59%), Positives = 24/32 (75%)
 Frame = +2

Query: 356 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           +K +K I+V TGAGISTS GIPDFR   G ++
Sbjct: 257 IKKAKKILVVTGAGISTSLGIPDFRSSKGFYS 288


>UniRef50_Q0UMU7 Cluster: Putative uncharacterized protein; n=1;
           Phaeosphaeria nodorum|Rep: Putative uncharacterized
           protein - Phaeosphaeria nodorum (Septoria nodorum)
          Length = 670

 Score = 42.7 bits (96), Expect = 0.008
 Identities = 24/54 (44%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKPTINVSFADA 502
           L  ++   + IVV  GAGIS SAGIPDFR   G++ +L+KE K  +      DA
Sbjct: 117 LLNVLHKKRKIVVIAGAGISVSAGIPDFRSATGLFNSLKKEHKLKSSGKDLFDA 170


>UniRef50_O94066 Cluster: Transcription regulatory protein; n=6;
           Saccharomycetales|Rep: Transcription regulatory protein
           - Candida albicans (Yeast)
          Length = 331

 Score = 42.7 bits (96), Expect = 0.008
 Identities = 18/32 (56%), Positives = 23/32 (71%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPN 439
           +A+ VK+ K +    GAGIST AGIPDFR P+
Sbjct: 11  VAEAVKNGKKVTFFNGAGISTGAGIPDFRSPD 42


>UniRef50_Q96EB6 Cluster: NAD-dependent deacetylase sirtuin-1; n=29;
           Euteleostomi|Rep: NAD-dependent deacetylase sirtuin-1 -
           Homo sapiens (Human)
          Length = 747

 Score = 42.7 bits (96), Expect = 0.008
 Identities = 17/33 (51%), Positives = 26/33 (78%)
 Frame = +2

Query: 350 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +L+++ K I+V TGAG+S S GIPDFR  +G++
Sbjct: 248 KLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIY 280


>UniRef50_Q9UR39 Cluster: NAD-dependent deacetylase hst4; n=1;
           Schizosaccharomyces pombe|Rep: NAD-dependent deacetylase
           hst4 - Schizosaccharomyces pombe (Fission yeast)
          Length = 415

 Score = 42.7 bits (96), Expect = 0.008
 Identities = 19/36 (52%), Positives = 25/36 (69%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           L   ++ +K IVV TGAGIS  AGIPDFR   G+++
Sbjct: 50  LVSAIRKAKRIVVVTGAGISCDAGIPDFRSSEGLFS 85


>UniRef50_A4J646 Cluster: Silent information regulator protein Sir2;
           n=2; Peptococcaceae|Rep: Silent information regulator
           protein Sir2 - Desulfotomaculum reducens MI-1
          Length = 256

 Score = 42.3 bits (95), Expect = 0.011
 Identities = 19/36 (52%), Positives = 25/36 (69%), Gaps = 1/36 (2%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPN-GVW 448
           L +L+K +   +  TGAGIST +GIPDFR  N G+W
Sbjct: 10  LTELIKKAGKTIALTGAGISTESGIPDFRSKNTGLW 45


>UniRef50_A1HU63 Cluster: Silent information regulator protein Sir2;
           n=1; Thermosinus carboxydivorans Nor1|Rep: Silent
           information regulator protein Sir2 - Thermosinus
           carboxydivorans Nor1
          Length = 243

 Score = 42.3 bits (95), Expect = 0.011
 Identities = 18/34 (52%), Positives = 25/34 (73%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGV 445
           L + ++ + H  V TGAGIST++GIPDFRG N +
Sbjct: 10  LVECLRAANHATVLTGAGISTASGIPDFRGINRI 43


>UniRef50_A7RMK8 Cluster: Predicted protein; n=5; Eumetazoa|Rep:
           Predicted protein - Nematostella vectensis
          Length = 273

 Score = 42.3 bits (95), Expect = 0.011
 Identities = 18/35 (51%), Positives = 24/35 (68%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           L  L+  +K+I+  TGAGIS  +GIP FRG  G+W
Sbjct: 18  LKDLLSKAKNILFLTGAGISAESGIPTFRGAGGLW 52


>UniRef50_A0D0F1 Cluster: Chromosome undetermined scaffold_33, whole
           genome shotgun sequence; n=2; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_33,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 264

 Score = 42.3 bits (95), Expect = 0.011
 Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 5/60 (8%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL-----EKEGKKPTINVSFADAQP 508
           + + +K+ +  ++  GAG+   +G+PDFRG  G WT+      K G     N SF D  P
Sbjct: 1   MQKYIKECQAFIITAGAGMGVDSGLPDFRGNKGFWTVYRPFENKFGFTDCANPSFMDYNP 60


>UniRef50_Q6BPA4 Cluster: Debaryomyces hansenii chromosome E of
           strain CBS767 of Debaryomyces hansenii; n=6;
           Saccharomycetales|Rep: Debaryomyces hansenii chromosome
           E of strain CBS767 of Debaryomyces hansenii -
           Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
          Length = 438

 Score = 42.3 bits (95), Expect = 0.011
 Identities = 21/50 (42%), Positives = 35/50 (70%)
 Frame = +2

Query: 311 SNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEK 460
           SN+++  K   +++++  S+  VV TGAGIS +AGIPDFR  +G++ + K
Sbjct: 12  SNEQI--KLSEVSKIIFKSRKAVVLTGAGISCNAGIPDFRSSDGLYNMVK 59


>UniRef50_A5DSX8 Cluster: NAD-dependent histone deacetylase SIR2;
           n=1; Lodderomyces elongisporus NRRL YB-4239|Rep:
           NAD-dependent histone deacetylase SIR2 - Lodderomyces
           elongisporus (Yeast) (Saccharomyces elongisporus)
          Length = 568

 Score = 42.3 bits (95), Expect = 0.011
 Identities = 19/34 (55%), Positives = 25/34 (73%)
 Frame = +2

Query: 353 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTL 454
           L++ S  I+V TGAGISTS GIPDFR   G +++
Sbjct: 252 LIQKSHKILVITGAGISTSLGIPDFRSSQGFYSM 285


>UniRef50_A4RMS1 Cluster: Putative uncharacterized protein; n=2;
           Sordariomycetes|Rep: Putative uncharacterized protein -
           Magnaporthe grisea (Rice blast fungus) (Pyricularia
           grisea)
          Length = 666

 Score = 42.3 bits (95), Expect = 0.011
 Identities = 18/35 (51%), Positives = 26/35 (74%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           L ++++  K IV+  GAGIS SAGIPDFR  +G++
Sbjct: 132 LTKVLRKKKRIVIIAGAGISVSAGIPDFRSQSGLF 166


>UniRef50_Q5KPC9 Cluster: Hst3 protein, putative; n=2;
           Filobasidiella neoformans|Rep: Hst3 protein, putative -
           Cryptococcus neoformans (Filobasidiella neoformans)
          Length = 389

 Score = 41.9 bits (94), Expect = 0.015
 Identities = 19/36 (52%), Positives = 26/36 (72%)
 Frame = +2

Query: 356 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKE 463
           V  ++ IV  +GAGIS S+GIPDFR   G+++L KE
Sbjct: 32  VAKARRIVTVSGAGISCSSGIPDFRSEGGLYSLVKE 67


>UniRef50_Q4PG00 Cluster: Putative uncharacterized protein; n=1;
           Ustilago maydis|Rep: Putative uncharacterized protein -
           Ustilago maydis (Smut fungus)
          Length = 596

 Score = 41.9 bits (94), Expect = 0.015
 Identities = 19/40 (47%), Positives = 28/40 (70%), Gaps = 1/40 (2%)
 Frame = +2

Query: 353 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-LEKEGK 469
           L+   K I++ +GAGIS S GIPDFR  +G++  L+ EG+
Sbjct: 186 LLSTRKRIMILSGAGISVSCGIPDFRSKDGIYAILQSEGQ 225


>UniRef50_A5DNV7 Cluster: Putative uncharacterized protein; n=1;
           Pichia guilliermondii|Rep: Putative uncharacterized
           protein - Pichia guilliermondii (Yeast) (Candida
           guilliermondii)
          Length = 403

 Score = 41.9 bits (94), Expect = 0.015
 Identities = 24/59 (40%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
 Frame = +2

Query: 353 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-LEKEGKKPTINVSFADAQPQKPI*F 526
           +++ +K I+V TGAGISTS GIPDFR   G+++ L + G +    V   D   + P  F
Sbjct: 112 VLEKAKKILVVTGAGISTSLGIPDFRSFQGIYSQLSRSGLENAQQVFHIDRFCKDPTLF 170


>UniRef50_Q9NXA8 Cluster: NAD-dependent deacetylase sirtuin-5; n=28;
           Coelomata|Rep: NAD-dependent deacetylase sirtuin-5 -
           Homo sapiens (Human)
          Length = 310

 Score = 41.9 bits (94), Expect = 0.015
 Identities = 15/28 (53%), Positives = 21/28 (75%)
 Frame = +2

Query: 365 SKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +KHIV+ +GAG+S  +G+P FRG  G W
Sbjct: 50  AKHIVIISGAGVSAESGVPTFRGAGGYW 77


>UniRef50_Q97MB4 Cluster: NAD-dependent deacetylase; n=7;
           Bacteria|Rep: NAD-dependent deacetylase - Clostridium
           acetobutylicum
          Length = 245

 Score = 41.9 bits (94), Expect = 0.015
 Identities = 21/53 (39%), Positives = 31/53 (58%)
 Frame = +2

Query: 317 DKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKP 475
           DK+N+    L ++V +S  IV   GAG+ST + IPDFR  NG++  +     P
Sbjct: 5   DKINE----LKKIVAESSSIVFFGGAGVSTESNIPDFRSENGLYKTKNNFSYP 53


>UniRef50_A6Q2C0 Cluster: Transcriptional regulator, Sir2 family;
           n=2; Bacteria|Rep: Transcriptional regulator, Sir2
           family - Nitratiruptor sp. (strain SB155-2)
          Length = 268

 Score = 41.5 bits (93), Expect = 0.019
 Identities = 15/40 (37%), Positives = 25/40 (62%)
 Frame = +2

Query: 353 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKK 472
           L+K + ++++  GAG+   +G+PDFRG +G W      KK
Sbjct: 8   LIKQADYLLITAGAGMGVDSGLPDFRGVHGFWRAYPAAKK 47


>UniRef50_A4JJP4 Cluster: Silent information regulator protein Sir2;
           n=1; Burkholderia vietnamiensis G4|Rep: Silent
           information regulator protein Sir2 - Burkholderia
           vietnamiensis (strain G4 / LMG 22486)
           (Burkholderiacepacia (strain R1808))
          Length = 273

 Score = 41.5 bits (93), Expect = 0.019
 Identities = 14/35 (40%), Positives = 24/35 (68%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           A  + ++  +++  GAG+S  +G+PDFRG  G+WT
Sbjct: 12  ASWIANADALIIAAGAGMSVDSGLPDFRGSQGIWT 46


>UniRef50_A3JEV2 Cluster: NAD-dependent deacetylase; n=2;
           Marinobacter|Rep: NAD-dependent deacetylase -
           Marinobacter sp. ELB17
          Length = 300

 Score = 41.5 bits (93), Expect = 0.019
 Identities = 16/40 (40%), Positives = 25/40 (62%)
 Frame = +2

Query: 329 QKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           Q   +LA  +     +++ TGAG+ST +GIPD+R  +G W
Sbjct: 31  QAGAMLADYIHSHPRLLILTGAGVSTDSGIPDYRDGDGAW 70


>UniRef50_Q4QB33 Cluster: Sir2-family protein-like protein; n=4;
           Trypanosomatidae|Rep: Sir2-family protein-like protein -
           Leishmania major
          Length = 320

 Score = 41.5 bits (93), Expect = 0.019
 Identities = 18/28 (64%), Positives = 21/28 (75%)
 Frame = +2

Query: 359 KDSKHIVVHTGAGISTSAGIPDFRGPNG 442
           K  +  VV TGAG ST +GIPD+RGPNG
Sbjct: 18  KRGRGCVVLTGAGCSTESGIPDYRGPNG 45


>UniRef50_Q2H5A0 Cluster: Putative uncharacterized protein; n=1;
           Chaetomium globosum|Rep: Putative uncharacterized
           protein - Chaetomium globosum (Soil fungus)
          Length = 387

 Score = 41.5 bits (93), Expect = 0.019
 Identities = 18/24 (75%), Positives = 21/24 (87%)
 Frame = +2

Query: 365 SKHIVVHTGAGISTSAGIPDFRGP 436
           ++ IVV TGAGIST+AGIPDFR P
Sbjct: 34  ARRIVVMTGAGISTAAGIPDFRSP 57


>UniRef50_O94640 Cluster: NAD-dependent histone deacetylase sir2;
           n=1; Schizosaccharomyces pombe|Rep: NAD-dependent
           histone deacetylase sir2 - Schizosaccharomyces pombe
           (Fission yeast)
          Length = 475

 Score = 41.5 bits (93), Expect = 0.019
 Identities = 19/35 (54%), Positives = 25/35 (71%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +  L+K +K++VV  GAGISTS GI DFR  NG +
Sbjct: 149 VVNLLKKAKNVVVLVGAGISTSLGILDFRSDNGFY 183


>UniRef50_UPI0000E49AD8 Cluster: PREDICTED: similar to NAD-dependent
           deacetylase sirtuin 2 homolog; n=1; Strongylocentrotus
           purpuratus|Rep: PREDICTED: similar to NAD-dependent
           deacetylase sirtuin 2 homolog - Strongylocentrotus
           purpuratus
          Length = 400

 Score = 41.1 bits (92), Expect = 0.025
 Identities = 19/33 (57%), Positives = 25/33 (75%), Gaps = 2/33 (6%)
 Frame = +2

Query: 344 LAQLVKDSK--HIVVHTGAGISTSAGIPDFRGP 436
           +A  +K+ K   ++V +GAGISTSAGIPDFR P
Sbjct: 64  IADFIKEGKCKKVIVMSGAGISTSAGIPDFRTP 96


>UniRef50_Q6C219 Cluster: Yarrowia lipolytica chromosome F of strain
           CLIB122 of Yarrowia lipolytica; n=1; Yarrowia
           lipolytica|Rep: Yarrowia lipolytica chromosome F of
           strain CLIB122 of Yarrowia lipolytica - Yarrowia
           lipolytica (Candida lipolytica)
          Length = 320

 Score = 41.1 bits (92), Expect = 0.025
 Identities = 23/53 (43%), Positives = 35/53 (66%)
 Frame = +2

Query: 290 GVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           G  E   ++ K++    LL +L + +++IVV  GAGISTS GIPDFR  +G++
Sbjct: 36  GDVESLAAHSKIHTFGDLLREL-ETAQNIVVLCGAGISTSLGIPDFRSADGLY 87


>UniRef50_A4QUX8 Cluster: Putative uncharacterized protein; n=1;
           Magnaporthe grisea|Rep: Putative uncharacterized protein
           - Magnaporthe grisea (Rice blast fungus) (Pyricularia
           grisea)
          Length = 460

 Score = 41.1 bits (92), Expect = 0.025
 Identities = 24/53 (45%), Positives = 33/53 (62%), Gaps = 5/53 (9%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGP-NGVWTLEKEGKKP----TINVSFADAQPQ 511
           K I V TGAGIST+AGIPDFR P  G+++  +  K P      ++SF   +P+
Sbjct: 40  KRITVMTGAGISTAAGIPDFRSPGTGLYSNLERLKLPEPEAVFDISFFRDRPE 92


>UniRef50_A1ZHW6 Cluster: NAD-dependent deacetylase; n=2;
           Microscilla marina ATCC 23134|Rep: NAD-dependent
           deacetylase - Microscilla marina ATCC 23134
          Length = 279

 Score = 40.7 bits (91), Expect = 0.034
 Identities = 18/38 (47%), Positives = 22/38 (57%)
 Frame = +2

Query: 362 DSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKP 475
           D   +VV TGAGIS  +GIP FRG  G W +     +P
Sbjct: 17  DQAKMVVLTGAGISAESGIPTFRGKEGYWKIGSVNYQP 54


>UniRef50_Q7QZ36 Cluster: GLP_464_21655_23334; n=1; Giardia lamblia
           ATCC 50803|Rep: GLP_464_21655_23334 - Giardia lamblia
           ATCC 50803
          Length = 559

 Score = 40.7 bits (91), Expect = 0.034
 Identities = 22/55 (40%), Positives = 34/55 (61%), Gaps = 4/55 (7%)
 Frame = +2

Query: 356 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT-LEKEG-KKPT--INVSFADAQP 508
           ++ ++ ++   GAGIS SAGIPDFR  NG++  L++   +KPT   N+ F    P
Sbjct: 160 LRRARKVIFLVGAGISVSAGIPDFRSKNGIYNRLQQYNLQKPTDMFNLDFFRGNP 214


>UniRef50_Q2HG51 Cluster: Putative uncharacterized protein; n=2;
           Pezizomycotina|Rep: Putative uncharacterized protein -
           Chaetomium globosum (Soil fungus)
          Length = 594

 Score = 40.7 bits (91), Expect = 0.034
 Identities = 24/54 (44%), Positives = 29/54 (53%), Gaps = 1/54 (1%)
 Frame = +2

Query: 356 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEGKKPTINVSFADAQPQK 514
           ++  K IVV  GAGIS SAGIPDFR   G++ TL  + K         DA   K
Sbjct: 46  LRKKKKIVVIAGAGISVSAGIPDFRSSTGLFATLRGQHKLKASGKHLFDASVYK 99


>UniRef50_Q899G3 Cluster: NAD-dependent deacetylase; n=19; cellular
           organisms|Rep: NAD-dependent deacetylase - Clostridium
           tetani
          Length = 247

 Score = 40.7 bits (91), Expect = 0.034
 Identities = 17/35 (48%), Positives = 24/35 (68%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           L +L+K S +IV   GAG+ST + IPDFR   G++
Sbjct: 7   LKELIKSSSNIVFFGGAGVSTESNIPDFRSEEGLY 41


>UniRef50_Q81NT6 Cluster: NAD-dependent deacetylase; n=11; Bacillus
           cereus group|Rep: NAD-dependent deacetylase - Bacillus
           anthracis
          Length = 242

 Score = 40.7 bits (91), Expect = 0.034
 Identities = 17/32 (53%), Positives = 24/32 (75%)
 Frame = +2

Query: 353 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +++ +K I V TGAG ST +GIPDFR  NG++
Sbjct: 10  ILEKAKKITVLTGAGASTESGIPDFRSANGLY 41


>UniRef50_UPI0000D578DC Cluster: PREDICTED: similar to sirtuin 5
           (silent mating type information regulation 2 homolog) 5;
           n=1; Tribolium castaneum|Rep: PREDICTED: similar to
           sirtuin 5 (silent mating type information regulation 2
           homolog) 5 - Tribolium castaneum
          Length = 254

 Score = 40.3 bits (90), Expect = 0.044
 Identities = 16/33 (48%), Positives = 23/33 (69%)
 Frame = +2

Query: 350 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           ++V  ++ IV  TGAG+S  +GIP FRG  G+W
Sbjct: 14  RVVSQARSIVALTGAGVSAESGIPVFRGAGGLW 46


>UniRef50_Q21KQ1 Cluster: Silent information regulator protein Sir2;
           n=2; Gammaproteobacteria|Rep: Silent information
           regulator protein Sir2 - Saccharophagus degradans
           (strain 2-40 / ATCC 43961 / DSM 17024)
          Length = 235

 Score = 40.3 bits (90), Expect = 0.044
 Identities = 17/30 (56%), Positives = 21/30 (70%)
 Frame = +2

Query: 359 KDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           KD K IVV TGAG+S  +G+  FR  NG+W
Sbjct: 5   KDYKRIVVLTGAGVSAESGLKTFRDNNGLW 34


>UniRef50_Q046W9 Cluster: NAD-dependent protein deacetylase, SIR2
           family; n=6; Lactobacillus|Rep: NAD-dependent protein
           deacetylase, SIR2 family - Lactobacillus gasseri (strain
           ATCC 33323 / DSM 20243)
          Length = 237

 Score = 40.3 bits (90), Expect = 0.044
 Identities = 19/64 (29%), Positives = 33/64 (51%)
 Frame = +2

Query: 323 LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADA 502
           LN +   L   + ++ H+   TGAG+ST + IPD+R  NG++    E  +  ++      
Sbjct: 3   LNNQIAALQADLNNAHHVTYLTGAGVSTPSHIPDYRSKNGIYNGISESPEQILSEDTLFH 62

Query: 503 QPQK 514
           +P K
Sbjct: 63  EPAK 66


>UniRef50_A6WG46 Cluster: Silent information regulator protein Sir2;
           n=4; Actinomycetales|Rep: Silent information regulator
           protein Sir2 - Kineococcus radiotolerans SRS30216
          Length = 279

 Score = 40.3 bits (90), Expect = 0.044
 Identities = 19/33 (57%), Positives = 24/33 (72%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNG 442
           LA L+ D   +VV  GAG+ST +GIPD+RGP G
Sbjct: 7   LADLL-DGGRVVVLEGAGMSTGSGIPDYRGPGG 38


>UniRef50_Q1EP52 Cluster: Transcriptional regulator Sir2 family
           protein; n=1; Musa balbisiana|Rep: Transcriptional
           regulator Sir2 family protein - Musa balbisiana (Banana)
          Length = 217

 Score = 40.3 bits (90), Expect = 0.044
 Identities = 18/30 (60%), Positives = 23/30 (76%)
 Frame = +2

Query: 341 LLAQLVKDSKHIVVHTGAGISTSAGIPDFR 430
           LL Q +  S+ +VV TGAGIST +GIPD+R
Sbjct: 175 LLYQFIDTSRKLVVLTGAGISTESGIPDYR 204


>UniRef50_Q54QE6 Cluster: Zn finger-containing protein; n=5;
           Eukaryota|Rep: Zn finger-containing protein -
           Dictyostelium discoideum AX4
          Length = 512

 Score = 40.3 bits (90), Expect = 0.044
 Identities = 17/23 (73%), Positives = 20/23 (86%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGP 436
           K+I+V TGAGIS +AGIPDFR P
Sbjct: 251 KNIIVMTGAGISVAAGIPDFRSP 273


>UniRef50_Q9USN7 Cluster: Sir2 family histone deacetylase Hst2; n=1;
           Schizosaccharomyces pombe|Rep: Sir2 family histone
           deacetylase Hst2 - Schizosaccharomyces pombe (Fission
           yeast)
          Length = 332

 Score = 40.3 bits (90), Expect = 0.044
 Identities = 20/33 (60%), Positives = 24/33 (72%), Gaps = 2/33 (6%)
 Frame = +2

Query: 344 LAQLVKDSK--HIVVHTGAGISTSAGIPDFRGP 436
           +A L+K+ K   I V  GAGIST+AGIPDFR P
Sbjct: 18  VASLIKEGKVKKICVMVGAGISTAAGIPDFRSP 50


>UniRef50_Q5KG84 Cluster: Hst4 protein, putative; n=2;
           Filobasidiella neoformans|Rep: Hst4 protein, putative -
           Cryptococcus neoformans (Filobasidiella neoformans)
          Length = 478

 Score = 40.3 bits (90), Expect = 0.044
 Identities = 23/53 (43%), Positives = 36/53 (67%)
 Frame = +2

Query: 308 DSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEG 466
           D  D L Q   ++A+L + +K IVV +GAG+ST A IPDFR  +G+++ + +G
Sbjct: 28  DVEDTLRQ---VVARL-RMAKRIVVVSGAGVSTGAAIPDFRSASGLFSGKTKG 76


>UniRef50_A3LRA1 Cluster: Transcriptional regulatory protein; n=2;
           Saccharomycetales|Rep: Transcriptional regulatory
           protein - Pichia stipitis (Yeast)
          Length = 311

 Score = 40.3 bits (90), Expect = 0.044
 Identities = 16/42 (38%), Positives = 27/42 (64%)
 Frame = +2

Query: 323 LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           ++++ V   + +K  + IV   GAG+S S+G+P FRG  G+W
Sbjct: 1   MSKQLVEFQEYLKTCRKIVALVGAGLSVSSGLPTFRGSQGLW 42


>UniRef50_A1CD03 Cluster: SIR2 family histone deacetylase, putative;
           n=2; Trichocomaceae|Rep: SIR2 family histone
           deacetylase, putative - Aspergillus clavatus
          Length = 329

 Score = 40.3 bits (90), Expect = 0.044
 Identities = 20/33 (60%), Positives = 24/33 (72%), Gaps = 2/33 (6%)
 Frame = +2

Query: 344 LAQLVKDS--KHIVVHTGAGISTSAGIPDFRGP 436
           +A L+K    + IVV  GAGIST+AGIPDFR P
Sbjct: 7   IATLIKSGQIRRIVVLVGAGISTAAGIPDFRSP 39


>UniRef50_Q67KQ0 Cluster: NAD-dependent deacetylase; n=1;
           Symbiobacterium thermophilum|Rep: NAD-dependent
           deacetylase - Symbiobacterium thermophilum
          Length = 251

 Score = 40.3 bits (90), Expect = 0.044
 Identities = 16/34 (47%), Positives = 24/34 (70%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           A+ ++ S++ V  TGAG ST +G+PDFR   G+W
Sbjct: 9   ARALQASRYAVALTGAGASTESGLPDFRSNTGLW 42


>UniRef50_Q607X6 Cluster: NAD-dependent deacetylase; n=1;
           Methylococcus capsulatus|Rep: NAD-dependent deacetylase
           - Methylococcus capsulatus
          Length = 255

 Score = 40.3 bits (90), Expect = 0.044
 Identities = 20/37 (54%), Positives = 25/37 (67%), Gaps = 1/37 (2%)
 Frame = +2

Query: 341 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGP-NGVW 448
           LLA L +D++HI V TGAG+S  +GIP FR    G W
Sbjct: 7   LLASL-RDARHIAVFTGAGVSAESGIPTFRDALTGFW 42


>UniRef50_P53688 Cluster: NAD-dependent histone deacetylase HST4;
           n=5; Saccharomycetales|Rep: NAD-dependent histone
           deacetylase HST4 - Saccharomyces cerevisiae (Baker's
           yeast)
          Length = 370

 Score = 40.3 bits (90), Expect = 0.044
 Identities = 18/34 (52%), Positives = 24/34 (70%)
 Frame = +2

Query: 365 SKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEG 466
           SK +VV +GAGIS +AGIPDFR   G+++    G
Sbjct: 92  SKRMVVVSGAGISVAAGIPDFRSSEGIFSTVNGG 125


>UniRef50_Q3E2I1 Cluster: Silent information regulator protein Sir2;
           n=7; Bacteria|Rep: Silent information regulator protein
           Sir2 - Chloroflexus aurantiacus J-10-fl
          Length = 254

 Score = 39.9 bits (89), Expect = 0.059
 Identities = 19/47 (40%), Positives = 29/47 (61%), Gaps = 1/47 (2%)
 Frame = +2

Query: 314 NDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFR-GPNGVWT 451
           ND L+    +LA  +  ++H+ V TGAG+S  +GIP FR    G+W+
Sbjct: 2   ND-LDDVITILATALSTARHVTVLTGAGVSAESGIPTFRDAQTGLWS 47


>UniRef50_Q22ZC3 Cluster: Transcriptional regulator, Sir2 family
           protein; n=1; Tetrahymena thermophila SB210|Rep:
           Transcriptional regulator, Sir2 family protein -
           Tetrahymena thermophila SB210
          Length = 308

 Score = 39.9 bits (89), Expect = 0.059
 Identities = 19/28 (67%), Positives = 19/28 (67%)
 Frame = +2

Query: 353 LVKDSKHIVVHTGAGISTSAGIPDFRGP 436
           L K  K I   TGAGIS SAGIPDFR P
Sbjct: 63  LAKKYKQIAFLTGAGISVSAGIPDFRSP 90


>UniRef50_A4VDQ9 Cluster: Chromatin regulatory protein sir2; n=1;
           Tetrahymena thermophila SB210|Rep: Chromatin regulatory
           protein sir2 - Tetrahymena thermophila SB210
          Length = 279

 Score = 39.9 bits (89), Expect = 0.059
 Identities = 21/36 (58%), Positives = 28/36 (77%), Gaps = 2/36 (5%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGPN-GVWT-LEKEGK 469
           K I+V TGAGIST+AGIPDFR  + G++  L+K G+
Sbjct: 31  KKIIVLTGAGISTNAGIPDFRSKDTGLYARLKKSGQ 66


>UniRef50_A0DQW0 Cluster: Chromosome undetermined scaffold_6, whole
           genome shotgun sequence; n=3; Paramecium
           tetraurelia|Rep: Chromosome undetermined scaffold_6,
           whole genome shotgun sequence - Paramecium tetraurelia
          Length = 367

 Score = 39.9 bits (89), Expect = 0.059
 Identities = 17/52 (32%), Positives = 31/52 (59%)
 Frame = +2

Query: 308 DSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKE 463
           + N K  Q+  +       +K++++  GAG+S ++G+P FRG +G WT  K+
Sbjct: 101 EQNPKTAQEVTVEQAQKLITKNVLILCGAGLSHASGVPTFRGKDGYWTKGKD 152


>UniRef50_Q6BVM7 Cluster: Similar to CA4170|IPF7784 Candida
           albicans; n=2; Saccharomycetaceae|Rep: Similar to
           CA4170|IPF7784 Candida albicans - Debaryomyces hansenii
           (Yeast) (Torulaspora hansenii)
          Length = 301

 Score = 39.9 bits (89), Expect = 0.059
 Identities = 16/28 (57%), Positives = 20/28 (71%)
 Frame = +2

Query: 365 SKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           SK IV   GAG+S S+G+P FRG  G+W
Sbjct: 15  SKRIVALVGAGLSVSSGLPTFRGSQGLW 42


>UniRef50_Q4WFZ3 Cluster: SIR2 family histone deacetylase, putative;
           n=4; Trichocomaceae|Rep: SIR2 family histone
           deacetylase, putative - Aspergillus fumigatus (Sartorya
           fumigata)
          Length = 403

 Score = 39.9 bits (89), Expect = 0.059
 Identities = 20/33 (60%), Positives = 24/33 (72%), Gaps = 2/33 (6%)
 Frame = +2

Query: 344 LAQLVKDSK--HIVVHTGAGISTSAGIPDFRGP 436
           +A L+K  +   IVV  GAGIST+AGIPDFR P
Sbjct: 83  IANLIKSGQVHKIVVLVGAGISTAAGIPDFRSP 115


>UniRef50_Q7ZVK3 Cluster: NAD-dependent deacetylase sirtuin-2; n=12;
           Coelomata|Rep: NAD-dependent deacetylase sirtuin-2 -
           Danio rerio (Zebrafish) (Brachydanio rerio)
          Length = 379

 Score = 39.9 bits (89), Expect = 0.059
 Identities = 21/40 (52%), Positives = 24/40 (60%)
 Frame = +2

Query: 317 DKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGP 436
           D+L    V    L    K+I+   GAGISTSAGIPDFR P
Sbjct: 58  DELTLDSVARYILSGKCKNIICMVGAGISTSAGIPDFRSP 97


>UniRef50_P53687 Cluster: NAD-dependent histone deacetylase HST3;
           n=6; Saccharomycetales|Rep: NAD-dependent histone
           deacetylase HST3 - Saccharomyces cerevisiae (Baker's
           yeast)
          Length = 447

 Score = 39.9 bits (89), Expect = 0.059
 Identities = 18/33 (54%), Positives = 24/33 (72%)
 Frame = +2

Query: 365 SKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKE 463
           S+ I   TGAGIS +AGIPDFR  +G++ L K+
Sbjct: 52  SRRIACLTGAGISCNAGIPDFRSSDGLYDLVKK 84


>UniRef50_UPI00015B48CB Cluster: PREDICTED: similar to 85 kda
           calcium-independent phospholipase A2 (ipla2); n=1;
           Nasonia vitripennis|Rep: PREDICTED: similar to 85 kda
           calcium-independent phospholipase A2 (ipla2) - Nasonia
           vitripennis
          Length = 811

 Score = 39.5 bits (88), Expect = 0.078
 Identities = 20/54 (37%), Positives = 30/54 (55%)
 Frame = +2

Query: 308 DSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGK 469
           D  + L +KC+ LA  +     +V +  A IS +  IPD+RG NG+W   + GK
Sbjct: 65  DIPEILEEKCIRLAAAISRETSLV-YIVADISIAVSIPDYRGINGMWARMQLGK 117


>UniRef50_UPI000023E2DA Cluster: hypothetical protein FG00460.1;
           n=1; Gibberella zeae PH-1|Rep: hypothetical protein
           FG00460.1 - Gibberella zeae PH-1
          Length = 607

 Score = 39.5 bits (88), Expect = 0.078
 Identities = 19/39 (48%), Positives = 24/39 (61%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEK 460
           L   ++  K IVV  GAGIS +AGIPDFR   G++   K
Sbjct: 123 LRDTLRKKKKIVVIAGAGISVAAGIPDFRSSTGLFASVK 161


>UniRef50_A6LP94 Cluster: Silent information regulator protein Sir2;
           n=1; Thermosipho melanesiensis BI429|Rep: Silent
           information regulator protein Sir2 - Thermosipho
           melanesiensis BI429
          Length = 234

 Score = 39.5 bits (88), Expect = 0.078
 Identities = 16/31 (51%), Positives = 24/31 (77%)
 Frame = +2

Query: 356 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           + +  ++V  TGAGISTS+GIPDFR  +G++
Sbjct: 8   ILEEGNVVALTGAGISTSSGIPDFRSEDGLY 38


>UniRef50_Q23YS7 Cluster: Transcriptional regulator, Sir2 family
           protein; n=1; Tetrahymena thermophila SB210|Rep:
           Transcriptional regulator, Sir2 family protein -
           Tetrahymena thermophila SB210
          Length = 304

 Score = 39.5 bits (88), Expect = 0.078
 Identities = 13/36 (36%), Positives = 24/36 (66%)
 Frame = +2

Query: 341 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           L+A+ ++ +  +++  GAG+   +G+PDFRG  G W
Sbjct: 8   LIAKRIQSASCLIITAGAGMGVDSGLPDFRGKEGFW 43


>UniRef50_Q4P3S4 Cluster: Putative uncharacterized protein; n=1;
           Ustilago maydis|Rep: Putative uncharacterized protein -
           Ustilago maydis (Smut fungus)
          Length = 400

 Score = 39.5 bits (88), Expect = 0.078
 Identities = 22/55 (40%), Positives = 32/55 (58%), Gaps = 1/55 (1%)
 Frame = +2

Query: 341 LLAQLVKDSK-HIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADA 502
           L+A+ V  +K   ++ TGAGIS  +GI  +RG NG +T+ K   +P     F DA
Sbjct: 27  LVAEFVSAAKGKALIMTGAGISVDSGIAPYRGENGHYTIHKH-YRPIFYHEFVDA 80


>UniRef50_A1CTI6 Cluster: SIR2 family histone deacetylase, putative;
           n=8; Eurotiomycetidae|Rep: SIR2 family histone
           deacetylase, putative - Aspergillus clavatus
          Length = 320

 Score = 39.5 bits (88), Expect = 0.078
 Identities = 15/33 (45%), Positives = 22/33 (66%)
 Frame = +2

Query: 350 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           + +K  K I+   GAG+S S+G+P FRG  G+W
Sbjct: 16  EYLKGCKRIIALCGAGLSASSGLPTFRGAGGLW 48


>UniRef50_O59923 Cluster: NAD-dependent histone deacetylase SIR2;
           n=3; Candida albicans|Rep: NAD-dependent histone
           deacetylase SIR2 - Candida albicans (Yeast)
          Length = 515

 Score = 39.5 bits (88), Expect = 0.078
 Identities = 21/38 (55%), Positives = 26/38 (68%), Gaps = 3/38 (7%)
 Frame = +2

Query: 344 LAQLVKD---SKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           L  L+ D   +K I+V TGAGISTS GIPDFR   G++
Sbjct: 224 LPDLISDLSRAKKIMVVTGAGISTSLGIPDFRSFKGLY 261


>UniRef50_Q8U1Q1 Cluster: NAD-dependent deacetylase; n=19; cellular
           organisms|Rep: NAD-dependent deacetylase - Pyrococcus
           furiosus
          Length = 250

 Score = 39.5 bits (88), Expect = 0.078
 Identities = 15/35 (42%), Positives = 24/35 (68%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +++++  S   +  TGAGIS  +GIP FRG +G+W
Sbjct: 5   VSKILAKSSMAIAFTGAGISAESGIPTFRGKDGLW 39


>UniRef50_UPI0000519F58 Cluster: PREDICTED: similar to Sirt4
           CG3187-PC, isoform C isoform 2; n=2; Endopterygota|Rep:
           PREDICTED: similar to Sirt4 CG3187-PC, isoform C isoform
           2 - Apis mellifera
          Length = 302

 Score = 39.1 bits (87), Expect = 0.10
 Identities = 20/53 (37%), Positives = 28/53 (52%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADA 502
           L   +    +I V TGAGIST +GIPD+R   GV    +   KP +   F ++
Sbjct: 33  LKDFIDSHDNICVLTGAGISTESGIPDYRS-EGVGLYARSNHKPVLYKDFCNS 84


>UniRef50_UPI00004997CB Cluster: Sir2 family transcriptional
           regulator; n=2; Entamoeba histolytica HM-1:IMSS|Rep:
           Sir2 family transcriptional regulator - Entamoeba
           histolytica HM-1:IMSS
          Length = 346

 Score = 39.1 bits (87), Expect = 0.10
 Identities = 20/37 (54%), Positives = 23/37 (62%)
 Frame = +2

Query: 326 NQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGP 436
           N K   L    +   ++VV  GAGISTSAGIPDFR P
Sbjct: 89  NAKGFGLFMKYRKPSNVVVMAGAGISTSAGIPDFRTP 125


>UniRef50_A4A980 Cluster: NAD-dependent deacetylase; n=5;
           Gammaproteobacteria|Rep: NAD-dependent deacetylase -
           Congregibacter litoralis KT71
          Length = 241

 Score = 39.1 bits (87), Expect = 0.10
 Identities = 15/30 (50%), Positives = 19/30 (63%)
 Frame = +2

Query: 386 TGAGISTSAGIPDFRGPNGVWTLEKEGKKP 475
           TGAG+S  +GIP FRG +G WT+      P
Sbjct: 7   TGAGVSAESGIPTFRGEDGFWTIGSRNYTP 36


>UniRef50_A1I9S7 Cluster: NAD-dependent deacetylase; n=1; Candidatus
           Desulfococcus oleovorans Hxd3|Rep: NAD-dependent
           deacetylase - Candidatus Desulfococcus oleovorans Hxd3
          Length = 273

 Score = 39.1 bits (87), Expect = 0.10
 Identities = 15/34 (44%), Positives = 22/34 (64%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           A+++  +    V +GAG+S  +GIP FR P GVW
Sbjct: 11  AKVLAGASRAAVFSGAGVSAESGIPTFRDPGGVW 44


>UniRef50_A1FG80 Cluster: Silent information regulator protein Sir2;
           n=3; Pseudomonas|Rep: Silent information regulator
           protein Sir2 - Pseudomonas putida W619
          Length = 252

 Score = 39.1 bits (87), Expect = 0.10
 Identities = 16/35 (45%), Positives = 25/35 (71%), Gaps = 1/35 (2%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGP-NGVW 448
           A+ ++ ++HI+V TGAG+S  +GIP FR    G+W
Sbjct: 8   AEALRSAQHIMVFTGAGVSAGSGIPTFRDELTGLW 42


>UniRef50_Q54P49 Cluster: Zn finger-containing protein; n=1;
           Dictyostelium discoideum AX4|Rep: Zn finger-containing
           protein - Dictyostelium discoideum AX4
          Length = 456

 Score = 39.1 bits (87), Expect = 0.10
 Identities = 25/70 (35%), Positives = 40/70 (57%), Gaps = 4/70 (5%)
 Frame = +2

Query: 272 ENKGILGVPEKFDSNDKL-NQKCVLLAQLVKDSK--HIVVHTGAGISTSAGIPDFRG-PN 439
           +N  I+    K ++  ++ N K     +L+K+ K  +I+V TGAGIS ++GIPDFR    
Sbjct: 146 KNSNIIKNEIKIENEIEIENNKIKEFIKLIKNDKCKNIIVLTGAGISVASGIPDFRSVET 205

Query: 440 GVWTLEKEGK 469
           G++  E   K
Sbjct: 206 GLYNNENVSK 215


>UniRef50_Q298C7 Cluster: GA18650-PA; n=1; Drosophila
           pseudoobscura|Rep: GA18650-PA - Drosophila pseudoobscura
           (Fruit fly)
          Length = 381

 Score = 39.1 bits (87), Expect = 0.10
 Identities = 17/23 (73%), Positives = 18/23 (78%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGP 436
           K I+   GAGISTSAGIPDFR P
Sbjct: 76  KKIITMVGAGISTSAGIPDFRSP 98


>UniRef50_Q5KDE0 Cluster: NAD-dependent histone deacetylase,
           putative; n=2; Filobasidiella neoformans|Rep:
           NAD-dependent histone deacetylase, putative -
           Cryptococcus neoformans (Filobasidiella neoformans)
          Length = 413

 Score = 39.1 bits (87), Expect = 0.10
 Identities = 23/52 (44%), Positives = 31/52 (59%), Gaps = 2/52 (3%)
 Frame = +2

Query: 290 GVPEKFDSNDKLNQKCVLLAQLVK--DSKHIVVHTGAGISTSAGIPDFRGPN 439
           G+ +   S D LN      A  +K  ++K ++   GAGISTSAGIPDFR P+
Sbjct: 46  GIDDGALSGDDLNP-LRKAASFIKSGNAKDVIFLLGAGISTSAGIPDFRSPS 96


>UniRef50_P06700 Cluster: NAD-dependent histone deacetylase SIR2;
           n=13; Saccharomycetales|Rep: NAD-dependent histone
           deacetylase SIR2 - Saccharomyces cerevisiae (Baker's
           yeast)
          Length = 562

 Score = 39.1 bits (87), Expect = 0.10
 Identities = 17/34 (50%), Positives = 24/34 (70%)
 Frame = +2

Query: 350 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWT 451
           Q +  ++ I+V TGAG+STS GIPDFR   G ++
Sbjct: 249 QKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYS 282


>UniRef50_Q885X7 Cluster: NAD-dependent deacetylase 2; n=4;
           Pseudomonas|Rep: NAD-dependent deacetylase 2 -
           Pseudomonas syringae pv. tomato
          Length = 248

 Score = 39.1 bits (87), Expect = 0.10
 Identities = 17/43 (39%), Positives = 27/43 (62%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKP 475
           A  ++ +K I+V TGAG+S  +G+P +RG  G++  E E   P
Sbjct: 5   ASALRHAKRILVITGAGLSADSGLPTYRGVGGLYNGETEDGLP 47


>UniRef50_UPI000050FCF4 Cluster: COG0846: NAD-dependent protein
           deacetylases, SIR2 family; n=1; Brevibacterium linens
           BL2|Rep: COG0846: NAD-dependent protein deacetylases,
           SIR2 family - Brevibacterium linens BL2
          Length = 309

 Score = 38.7 bits (86), Expect = 0.14
 Identities = 21/51 (41%), Positives = 30/51 (58%), Gaps = 1/51 (1%)
 Frame = +2

Query: 296 PEKFDSNDKLNQKCVLLAQLVK-DSKHIVVHTGAGISTSAGIPDFRGPNGV 445
           PE   S+D++       A  V  D+    V TGAG+ST +G+PD+RGP+ V
Sbjct: 14  PEPSHSDDEIIDVLTGTAGAVGIDTSGWAVLTGAGMSTDSGVPDYRGPDAV 64


>UniRef50_Q4S7H2 Cluster: Chromosome 13 SCAF14715, whole genome
           shotgun sequence; n=6; Clupeocephala|Rep: Chromosome 13
           SCAF14715, whole genome shotgun sequence - Tetraodon
           nigroviridis (Green puffer)
          Length = 327

 Score = 38.7 bits (86), Expect = 0.14
 Identities = 22/47 (46%), Positives = 33/47 (70%), Gaps = 3/47 (6%)
 Frame = +2

Query: 344 LAQLVK--DSKHIVVHTGAGISTSAGIPDFRGP-NGVWTLEKEGKKP 475
           +A+LVK    +++VV  GAGIST++GIPDFR P  G++   ++ K P
Sbjct: 39  VARLVKLGRCRNVVVVAGAGISTASGIPDFRTPGTGLYANLEQYKLP 85


>UniRef50_Q03ZB1 Cluster: NAD-dependent protein deacetylase, SIR2
           family; n=3; Leuconostocaceae|Rep: NAD-dependent protein
           deacetylase, SIR2 family - Leuconostoc mesenteroides
           subsp. mesenteroides (strain ATCC 8293 /NCDO 523)
          Length = 234

 Score = 38.7 bits (86), Expect = 0.14
 Identities = 15/29 (51%), Positives = 23/29 (79%)
 Frame = +2

Query: 362 DSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           ++K+IV  TGAG+ST +GIPD+R   G++
Sbjct: 13  NAKNIVFMTGAGVSTLSGIPDYRSKGGIY 41


>UniRef50_Q8SSB6 Cluster: SIR2-LIKE PROTEIN INVOLVED IN TELOMERIC
           SILENCING; n=1; Encephalitozoon cuniculi|Rep: SIR2-LIKE
           PROTEIN INVOLVED IN TELOMERIC SILENCING -
           Encephalitozoon cuniculi
          Length = 425

 Score = 38.7 bits (86), Expect = 0.14
 Identities = 16/27 (59%), Positives = 22/27 (81%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGPNGVW 448
           + +VV TGAGIS S+GIPDFR  +G++
Sbjct: 86  RRVVVITGAGISVSSGIPDFRSKSGLF 112


>UniRef50_Q750H1 Cluster: AGL018Cp; n=1; Eremothecium gossypii|Rep:
           AGL018Cp - Ashbya gossypii (Yeast) (Eremothecium
           gossypii)
          Length = 340

 Score = 38.7 bits (86), Expect = 0.14
 Identities = 21/42 (50%), Positives = 25/42 (59%), Gaps = 1/42 (2%)
 Frame = +2

Query: 374 IVVHTGAGISTSAGIPDFRGPN-GVWTLEKEGKKPTINVSFA 496
           +V   GAGISTS GIPDFR PN G++    + K P     FA
Sbjct: 24  VVFLVGAGISTSCGIPDFRSPNTGLYHNLSKFKLPYAEAVFA 65


>UniRef50_A5DJ74 Cluster: Putative uncharacterized protein; n=1;
           Pichia guilliermondii|Rep: Putative uncharacterized
           protein - Pichia guilliermondii (Yeast) (Candida
           guilliermondii)
          Length = 522

 Score = 38.7 bits (86), Expect = 0.14
 Identities = 17/31 (54%), Positives = 23/31 (74%)
 Frame = +2

Query: 356 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           ++ +K I+V +GAGISTS GIPDFR   G +
Sbjct: 206 LQSAKKILVLSGAGISTSLGIPDFRSSQGFY 236


>UniRef50_A4RCT8 Cluster: Putative uncharacterized protein; n=3;
           Magnaporthe grisea|Rep: Putative uncharacterized protein
           - Magnaporthe grisea (Rice blast fungus) (Pyricularia
           grisea)
          Length = 1040

 Score = 38.7 bits (86), Expect = 0.14
 Identities = 15/28 (53%), Positives = 21/28 (75%)
 Frame = +2

Query: 365 SKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           S++IV   GAG+S S+G+  FRGP G+W
Sbjct: 33  SRNIVAIIGAGLSASSGLATFRGPGGLW 60


>UniRef50_Q8R216 Cluster: NAD-dependent deacetylase sirtuin-4; n=7;
           cellular organisms|Rep: NAD-dependent deacetylase
           sirtuin-4 - Mus musculus (Mouse)
          Length = 333

 Score = 38.7 bits (86), Expect = 0.14
 Identities = 20/60 (33%), Positives = 33/60 (55%)
 Frame = +2

Query: 329 QKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADAQP 508
           +K   L + +  SK ++V TGAGIST + IPD+R    V    +  ++P  ++ F  + P
Sbjct: 39  EKIKELQRFISLSKKLLVMTGAGISTESSIPDYRSEK-VGLYARTDRRPIQHIDFVRSAP 97


>UniRef50_Q9Y6E7 Cluster: NAD-dependent deacetylase sirtuin-4; n=23;
           Deuterostomia|Rep: NAD-dependent deacetylase sirtuin-4 -
           Homo sapiens (Human)
          Length = 314

 Score = 38.7 bits (86), Expect = 0.14
 Identities = 21/60 (35%), Positives = 33/60 (55%)
 Frame = +2

Query: 329 QKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADAQP 508
           +K   L + +  SK ++V TGAGIST +GIPD+R    V    +  ++P  +  F  + P
Sbjct: 42  EKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEK-VGLYARTDRRPIQHGDFVRSAP 100


>UniRef50_A7HID4 Cluster: Silent information regulator protein Sir2;
           n=9; Deltaproteobacteria|Rep: Silent information
           regulator protein Sir2 - Anaeromyxobacter sp. Fw109-5
          Length = 289

 Score = 38.3 bits (85), Expect = 0.18
 Identities = 18/52 (34%), Positives = 29/52 (55%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADA 502
           A  ++ +  +VV  GAG+   +G+PDFRG  G W      ++  + +SF DA
Sbjct: 9   AAALRSAGALVVTAGAGMGVDSGLPDFRGDQGFWKAYPPYER--LGLSFVDA 58


>UniRef50_A7H7B6 Cluster: Silent information regulator protein Sir2;
           n=2; Anaeromyxobacter|Rep: Silent information regulator
           protein Sir2 - Anaeromyxobacter sp. Fw109-5
          Length = 270

 Score = 38.3 bits (85), Expect = 0.18
 Identities = 17/45 (37%), Positives = 23/45 (51%)
 Frame = +2

Query: 341 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKP 475
           LL  + +    +V  TGAG+S  +GIP FRG  G W +      P
Sbjct: 8   LLDDVRRAQGRVVALTGAGVSAESGIPTFRGREGFWVVGSRNYMP 52


>UniRef50_A0PU12 Cluster: Sir2-like regulatory protein; n=1;
           Mycobacterium ulcerans Agy99|Rep: Sir2-like regulatory
           protein - Mycobacterium ulcerans (strain Agy99)
          Length = 283

 Score = 38.3 bits (85), Expect = 0.18
 Identities = 16/22 (72%), Positives = 19/22 (86%)
 Frame = +2

Query: 374 IVVHTGAGISTSAGIPDFRGPN 439
           I V TGAGIST +GIPD+RGP+
Sbjct: 15  IAVLTGAGISTDSGIPDYRGPD 36


>UniRef50_Q8IRR5 Cluster: CG3187-PC, isoform C; n=4; Diptera|Rep:
           CG3187-PC, isoform C - Drosophila melanogaster (Fruit
           fly)
          Length = 312

 Score = 38.3 bits (85), Expect = 0.18
 Identities = 19/50 (38%), Positives = 28/50 (56%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSF 493
           L   +    +++V TGAGIST +GIPD+R   GV    +   KP  ++ F
Sbjct: 38  LEDFLLSKPNVLVLTGAGISTESGIPDYRS-EGVGLYARSNHKPVQHMEF 86


>UniRef50_A2DKF0 Cluster: Transcriptional regulator, Sir2 family
           protein; n=1; Trichomonas vaginalis G3|Rep:
           Transcriptional regulator, Sir2 family protein -
           Trichomonas vaginalis G3
          Length = 347

 Score = 38.3 bits (85), Expect = 0.18
 Identities = 19/42 (45%), Positives = 29/42 (69%), Gaps = 1/42 (2%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW-TLEKEG 466
           + +L+++SKHI+V  GAG S     PDFR P G++ ++ KEG
Sbjct: 61  IIKLIENSKHIIVIIGAGASIG---PDFRSPGGLYDSIAKEG 99


>UniRef50_Q6CAJ8 Cluster: Similar to sp|P53687 Saccharomyces
           cerevisiae HST3 protein; n=1; Yarrowia lipolytica|Rep:
           Similar to sp|P53687 Saccharomyces cerevisiae HST3
           protein - Yarrowia lipolytica (Candida lipolytica)
          Length = 385

 Score = 38.3 bits (85), Expect = 0.18
 Identities = 18/29 (62%), Positives = 21/29 (72%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFR 430
           L Q++   K +V  TGAGIS SAGIPDFR
Sbjct: 17  LQQILGKCKRVVCVTGAGISCSAGIPDFR 45


>UniRef50_A4QX96 Cluster: Putative uncharacterized protein; n=2;
           Magnaporthe grisea|Rep: Putative uncharacterized protein
           - Magnaporthe grisea (Rice blast fungus) (Pyricularia
           grisea)
          Length = 534

 Score = 38.3 bits (85), Expect = 0.18
 Identities = 16/21 (76%), Positives = 18/21 (85%)
 Frame = +2

Query: 374 IVVHTGAGISTSAGIPDFRGP 436
           I++  GAGISTSAGIPDFR P
Sbjct: 38  IIILAGAGISTSAGIPDFRSP 58


>UniRef50_A3LN35 Cluster: NAD-dependent histone deacetylase SIR2;
           n=1; Pichia stipitis|Rep: NAD-dependent histone
           deacetylase SIR2 - Pichia stipitis (Yeast)
          Length = 391

 Score = 38.3 bits (85), Expect = 0.18
 Identities = 20/36 (55%), Positives = 26/36 (72%)
 Frame = +2

Query: 341 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           LL+ L   +K I+V +GAGISTS GIPDFR   G++
Sbjct: 103 LLSDLTS-AKKIMVISGAGISTSLGIPDFRSFKGLY 137


>UniRef50_A2QWZ2 Cluster: Function: human SIRT5 belongs to the
           Sir2-like proteins precursor; n=1; Aspergillus
           niger|Rep: Function: human SIRT5 belongs to the
           Sir2-like proteins precursor - Aspergillus niger
          Length = 258

 Score = 38.3 bits (85), Expect = 0.18
 Identities = 14/31 (45%), Positives = 21/31 (67%)
 Frame = +2

Query: 356 VKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +K  + ++   GAGIS S+G+P FRG  G+W
Sbjct: 18  LKGCRRVIALLGAGISASSGLPTFRGAGGLW 48


>UniRef50_Q7WLE5 Cluster: NAD-dependent deacetylase; n=47;
           Bacteria|Rep: NAD-dependent deacetylase - Bordetella
           bronchiseptica (Alcaligenes bronchisepticus)
          Length = 274

 Score = 38.3 bits (85), Expect = 0.18
 Identities = 21/51 (41%), Positives = 30/51 (58%), Gaps = 1/51 (1%)
 Frame = +2

Query: 365 SKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINV-SFADAQPQK 514
           S+ + V TGAG ST++GIPD+R   G W      +KP I+  +F   QP +
Sbjct: 18  SERLFVLTGAGCSTASGIPDYRDGQGQWK-----RKPPIDFQAFMGGQPAR 63


>UniRef50_UPI00015B4FA0 Cluster: PREDICTED: similar to chromatin
           regulatory protein sir2; n=1; Nasonia vitripennis|Rep:
           PREDICTED: similar to chromatin regulatory protein sir2
           - Nasonia vitripennis
          Length = 736

 Score = 37.9 bits (84), Expect = 0.24
 Identities = 23/53 (43%), Positives = 29/53 (54%)
 Frame = +2

Query: 341 LLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFAD 499
           +L   V  S  I V TGAGIST +GIPD+R   GV       ++P   VS+ D
Sbjct: 466 MLKHFVNTSGKICVITGAGISTESGIPDYRS-EGVGLFATSDRRP---VSYQD 514


>UniRef50_UPI00006CA40C Cluster: transcriptional regulator, Sir2
           family protein; n=1; Tetrahymena thermophila SB210|Rep:
           transcriptional regulator, Sir2 family protein -
           Tetrahymena thermophila SB210
          Length = 471

 Score = 37.9 bits (84), Expect = 0.24
 Identities = 20/35 (57%), Positives = 26/35 (74%), Gaps = 1/35 (2%)
 Frame = +2

Query: 374 IVVHTGAGISTSAGIPDFRGP-NGVWTLEKEGKKP 475
           IV  TGAGIS SAGIPDFR P +G+++  ++ K P
Sbjct: 214 IVFLTGAGISVSAGIPDFRTPGSGLYSQLQKYKLP 248


>UniRef50_Q4QKL5 Cluster: NAD-dependent deacetylase sirtuin 5; n=11;
           Haemophilus influenzae|Rep: NAD-dependent deacetylase
           sirtuin 5 - Haemophilus influenzae (strain 86-028NP)
          Length = 281

 Score = 37.9 bits (84), Expect = 0.24
 Identities = 17/50 (34%), Positives = 29/50 (58%)
 Frame = +2

Query: 350 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFAD 499
           +L++ +  I++  GAG+S  +G+PDFR   G W      K+   N+SF +
Sbjct: 10  ELIRKADGILITAGAGMSVDSGLPDFRSVGGFWNAYPMFKEH--NISFEE 57


>UniRef50_Q1D737 Cluster: NAD-dependent deacetylase; n=1; Myxococcus
           xanthus DK 1622|Rep: NAD-dependent deacetylase -
           Myxococcus xanthus (strain DK 1622)
          Length = 245

 Score = 37.9 bits (84), Expect = 0.24
 Identities = 16/33 (48%), Positives = 24/33 (72%), Gaps = 1/33 (3%)
 Frame = +2

Query: 353 LVKDSKH-IVVHTGAGISTSAGIPDFRGPNGVW 448
           L+ DS   ++V TGAG+S  +G+P FRG +G+W
Sbjct: 4   LILDSNTWLLVLTGAGVSAESGVPTFRGMSGLW 36


>UniRef50_A6XDL2 Cluster: Sirtuin 1; n=2; Schistosoma|Rep: Sirtuin 1
           - Schistosoma mansoni (Blood fluke)
          Length = 568

 Score = 37.9 bits (84), Expect = 0.24
 Identities = 17/32 (53%), Positives = 22/32 (68%)
 Frame = +2

Query: 353 LVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           L+     I+V TGAGIS S GIPDFR  +G++
Sbjct: 150 LLSTCTSILVITGAGISVSCGIPDFRSRDGIY 181


>UniRef50_Q8IXJ6 Cluster: NAD-dependent deacetylase sirtuin-2; n=31;
           Coelomata|Rep: NAD-dependent deacetylase sirtuin-2 -
           Homo sapiens (Human)
          Length = 389

 Score = 37.9 bits (84), Expect = 0.24
 Identities = 19/33 (57%), Positives = 25/33 (75%), Gaps = 2/33 (6%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGPN-GVW-TLEK 460
           + ++   GAGISTSAGIPDFR P+ G++  LEK
Sbjct: 77  RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEK 109


>UniRef50_Q6C8C7 Cluster: Similar to DEHA0C01507g Debaryomyces
           hansenii IPF 2468.1; n=2; Ascomycota|Rep: Similar to
           DEHA0C01507g Debaryomyces hansenii IPF 2468.1 - Yarrowia
           lipolytica (Candida lipolytica)
          Length = 303

 Score = 37.5 bits (83), Expect = 0.31
 Identities = 14/28 (50%), Positives = 20/28 (71%)
 Frame = +2

Query: 365 SKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           S+ I+   GAG+S S+G+P FRG  G+W
Sbjct: 16  SRKILALVGAGLSQSSGLPTFRGEGGIW 43


>UniRef50_A6SP88 Cluster: Putative uncharacterized protein; n=2;
           Sclerotiniaceae|Rep: Putative uncharacterized protein -
           Botryotinia fuckeliana B05.10
          Length = 332

 Score = 37.5 bits (83), Expect = 0.31
 Identities = 20/51 (39%), Positives = 28/51 (54%)
 Frame = +2

Query: 296 PEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           PE   SND  + K VL +     S  ++   GAG+  S+G+  FRGP G+W
Sbjct: 17  PEHRPSNDVASFKKVLAS-----STRVLALCGAGLGASSGLDTFRGPGGMW 62


>UniRef50_Q9NTG7 Cluster: NAD-dependent deacetylase sirtuin-3,
           mitochondrial precursor; n=22; Euteleostomi|Rep:
           NAD-dependent deacetylase sirtuin-3, mitochondrial
           precursor - Homo sapiens (Human)
          Length = 399

 Score = 37.5 bits (83), Expect = 0.31
 Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
 Frame = +2

Query: 311 SNDKLNQKCVLLAQLVKDS--KHIVVHTGAGISTSAGIPDFRGP 436
           S+DK       +A+L++    + +VV  GAGIST +GIPDFR P
Sbjct: 117 SSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSP 160


>UniRef50_UPI0000499DEA Cluster: Sir2 family transcriptional
           regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
           Sir2 family transcriptional regulator - Entamoeba
           histolytica HM-1:IMSS
          Length = 383

 Score = 37.1 bits (82), Expect = 0.41
 Identities = 15/23 (65%), Positives = 19/23 (82%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGP 436
           K+I+   GAG+ST+AGIPDFR P
Sbjct: 135 KNIIALVGAGMSTTAGIPDFRSP 157


>UniRef50_A2ABY8 Cluster: Sirtuin 7 (Silent mating type information
           regulation 2, homolog) 7; n=2; Murinae|Rep: Sirtuin 7
           (Silent mating type information regulation 2, homolog) 7
           - Mus musculus (Mouse)
          Length = 121

 Score = 37.1 bits (82), Expect = 0.41
 Identities = 19/43 (44%), Positives = 27/43 (62%)
 Frame = +2

Query: 299 EKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDF 427
           E  D  ++L +K   LA  V+ ++H+VV+TGAGIST   I  F
Sbjct: 78  EVCDDPEELRRKVRELAGAVRSARHLVVYTGAGISTCRQIDRF 120


>UniRef50_Q1RL71 Cluster: Zinc finger protein; n=2; Ciona
           intestinalis|Rep: Zinc finger protein - Ciona
           intestinalis (Transparent sea squirt)
          Length = 523

 Score = 37.1 bits (82), Expect = 0.41
 Identities = 17/33 (51%), Positives = 24/33 (72%), Gaps = 2/33 (6%)
 Frame = +2

Query: 344 LAQLVKDS--KHIVVHTGAGISTSAGIPDFRGP 436
           +A+L+     ++I+V  GAGIST +GIPDFR P
Sbjct: 110 VAELISSGGVRNIIVMAGAGISTGSGIPDFRTP 142


>UniRef50_Q882K4 Cluster: NAD-dependent deacetylase 3; n=5;
           Pseudomonas|Rep: NAD-dependent deacetylase 3 -
           Pseudomonas syringae pv. tomato
          Length = 281

 Score = 37.1 bits (82), Expect = 0.41
 Identities = 16/26 (61%), Positives = 21/26 (80%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGPNGV 445
           K  +V TGAGIST++GIPD+R  +GV
Sbjct: 20  KSFLVVTGAGISTASGIPDYRDKDGV 45


>UniRef50_Q7PS76 Cluster: ENSANGP00000025231; n=1; Anopheles gambiae
           str. PEST|Rep: ENSANGP00000025231 - Anopheles gambiae
           str. PEST
          Length = 182

 Score = 36.7 bits (81), Expect = 0.55
 Identities = 19/44 (43%), Positives = 26/44 (59%)
 Frame = +2

Query: 374 IVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKPTINVSFADAQ 505
           I+V TGAGIST +GIPD+R   GV    +   KP  +  F  ++
Sbjct: 1   ILVLTGAGISTESGIPDYRS-EGVGLYARSNHKPIQHGDFVKSE 43


>UniRef50_A2F9H1 Cluster: Transcriptional regulator, Sir2 family
           protein; n=2; Trichomonas vaginalis|Rep: Transcriptional
           regulator, Sir2 family protein - Trichomonas vaginalis
           G3
          Length = 304

 Score = 36.7 bits (81), Expect = 0.55
 Identities = 16/22 (72%), Positives = 19/22 (86%)
 Frame = +2

Query: 365 SKHIVVHTGAGISTSAGIPDFR 430
           +K I+  TGAGIST+AGIPDFR
Sbjct: 24  AKKIIFLTGAGISTAAGIPDFR 45


>UniRef50_Q89EA6 Cluster: NAD-dependent deacetylase 2; n=9;
           Proteobacteria|Rep: NAD-dependent deacetylase 2 -
           Bradyrhizobium japonicum
          Length = 273

 Score = 36.7 bits (81), Expect = 0.55
 Identities = 16/35 (45%), Positives = 22/35 (62%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           L   V   + + V TGAG ST++GIPD+R  +G W
Sbjct: 11  LQDFVARHQRLFVLTGAGCSTNSGIPDYRDSHGNW 45


>UniRef50_Q07FY7 Cluster: Sirtuin (Silent mating type information
           regulation 2 homolog) 3; n=3; Xenopus|Rep: Sirtuin
           (Silent mating type information regulation 2 homolog) 3
           - Xenopus tropicalis (Western clawed frog) (Silurana
           tropicalis)
          Length = 401

 Score = 36.3 bits (80), Expect = 0.72
 Identities = 15/22 (68%), Positives = 19/22 (86%)
 Frame = +2

Query: 371 HIVVHTGAGISTSAGIPDFRGP 436
           +I+V  GAGIST++GIPDFR P
Sbjct: 128 NIIVMAGAGISTASGIPDFRTP 149


>UniRef50_Q62HT8 Cluster: Transcriptional regulator, Sir2 family;
           n=39; Bacteria|Rep: Transcriptional regulator, Sir2
           family - Burkholderia mallei (Pseudomonas mallei)
          Length = 450

 Score = 36.3 bits (80), Expect = 0.72
 Identities = 13/25 (52%), Positives = 18/25 (72%)
 Frame = +2

Query: 374 IVVHTGAGISTSAGIPDFRGPNGVW 448
           ++V  GAGI   +G+PDFRG  G+W
Sbjct: 196 LLVTAGAGIGIDSGLPDFRGAEGLW 220


>UniRef50_A4A8B4 Cluster: Silent information regulator protein Sir2;
           n=1; Congregibacter litoralis KT71|Rep: Silent
           information regulator protein Sir2 - Congregibacter
           litoralis KT71
          Length = 297

 Score = 36.3 bits (80), Expect = 0.72
 Identities = 18/42 (42%), Positives = 25/42 (59%)
 Frame = +2

Query: 323 LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           L+ +   L+ L+ D   ++V TGAGIS S GIP +R   G W
Sbjct: 7   LHAESDFLSALI-DHAPVLVITGAGISVSTGIPTYRDEKGAW 47


>UniRef50_A1ZZG3 Cluster: NAD-dependent deacetylase; n=35;
           Bacteria|Rep: NAD-dependent deacetylase - Microscilla
           marina ATCC 23134
          Length = 245

 Score = 36.3 bits (80), Expect = 0.72
 Identities = 17/42 (40%), Positives = 26/42 (61%)
 Frame = +2

Query: 323 LNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           L+ K   +++ +   + IVV TGAGIS  +GI  FR  +G+W
Sbjct: 2   LSFKSQQVSKSIMSKQKIVVLTGAGISAESGISTFRDSDGLW 43


>UniRef50_A7SK95 Cluster: Predicted protein; n=1; Nematostella
           vectensis|Rep: Predicted protein - Nematostella
           vectensis
          Length = 323

 Score = 36.3 bits (80), Expect = 0.72
 Identities = 19/46 (41%), Positives = 27/46 (58%)
 Frame = +2

Query: 293 VPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFR 430
           VPE   S  +L+     L + + ++  I V TGAGIST +GI D+R
Sbjct: 36  VPEFHTSKQELSYITSRLDEFIAENPKIFVITGAGISTESGIRDYR 81


>UniRef50_Q6FKU1 Cluster: Similar to sp|P53686 Saccharomyces
           cerevisiae YPL015c; n=3; Saccharomycetales|Rep: Similar
           to sp|P53686 Saccharomyces cerevisiae YPL015c - Candida
           glabrata (Yeast) (Torulopsis glabrata)
          Length = 364

 Score = 36.3 bits (80), Expect = 0.72
 Identities = 15/24 (62%), Positives = 18/24 (75%)
 Frame = +2

Query: 365 SKHIVVHTGAGISTSAGIPDFRGP 436
           S  ++   GAGISTS+GIPDFR P
Sbjct: 16  SSKVIFLVGAGISTSSGIPDFRSP 39


>UniRef50_Q88BY5 Cluster: NAD-dependent deacetylase; n=9;
           Bacteria|Rep: NAD-dependent deacetylase - Pseudomonas
           putida (strain KT2440)
          Length = 262

 Score = 36.3 bits (80), Expect = 0.72
 Identities = 17/35 (48%), Positives = 23/35 (65%), Gaps = 1/35 (2%)
 Frame = +2

Query: 347 AQLVKDSKHIVVHTGAGISTSAGIPDFRGP-NGVW 448
           A+ ++ SK +V  TGAGIS  +GIP FR    G+W
Sbjct: 8   AEALRRSKTVVFFTGAGISADSGIPTFRDKLTGLW 42


>UniRef50_Q9I4E1 Cluster: NAD-dependent deacetylase 2; n=6;
           Pseudomonadaceae|Rep: NAD-dependent deacetylase 2 -
           Pseudomonas aeruginosa
          Length = 256

 Score = 36.3 bits (80), Expect = 0.72
 Identities = 16/44 (36%), Positives = 28/44 (63%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVWTLEKEGKKP 475
           +AQ ++ ++ I+V TGAG+S  +G+P +RG  G++    E   P
Sbjct: 10  VAQALRRAERILVITGAGLSADSGMPTYRGLGGLYNGRTEEGLP 53


>UniRef50_Q1D9X2 Cluster: Sir2 family protein; n=1; Myxococcus
           xanthus DK 1622|Rep: Sir2 family protein - Myxococcus
           xanthus (strain DK 1622)
          Length = 287

 Score = 35.9 bits (79), Expect = 0.96
 Identities = 15/20 (75%), Positives = 17/20 (85%)
 Frame = +2

Query: 377 VVHTGAGISTSAGIPDFRGP 436
           VV TGAG ST +GIPD+RGP
Sbjct: 30  VVLTGAGCSTESGIPDYRGP 49


>UniRef50_Q6MJJ2 Cluster: NAD-dependent deacetylase; n=5;
           Proteobacteria|Rep: NAD-dependent deacetylase -
           Bdellovibrio bacteriovorus
          Length = 235

 Score = 35.9 bits (79), Expect = 0.96
 Identities = 15/27 (55%), Positives = 20/27 (74%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGPNGVW 448
           K+IV+ TGAGIS  +GI  FR  +G+W
Sbjct: 7   KNIVILTGAGISAESGIRTFRDQDGLW 33


>UniRef50_Q8FUC8 Cluster: NAD-dependent deacetylase 1; n=6;
           Corynebacterium|Rep: NAD-dependent deacetylase 1 -
           Corynebacterium efficiens
          Length = 281

 Score = 35.9 bits (79), Expect = 0.96
 Identities = 13/23 (56%), Positives = 18/23 (78%)
 Frame = +2

Query: 374 IVVHTGAGISTSAGIPDFRGPNG 442
           ++  TGAG+ST +GIPD+R P G
Sbjct: 19  VLAVTGAGVSTDSGIPDYRSPRG 41


>UniRef50_UPI00005A356B Cluster: PREDICTED: similar to NAD-dependent
           deacetylase sirtuin-3, mitochondrial precursor
           (SIR2-like protein 3) (hSIRT3) isoform 1; n=2; Canis
           lupus familiaris|Rep: PREDICTED: similar to
           NAD-dependent deacetylase sirtuin-3, mitochondrial
           precursor (SIR2-like protein 3) (hSIRT3) isoform 1 -
           Canis familiaris
          Length = 248

 Score = 35.5 bits (78), Expect = 1.3
 Identities = 16/33 (48%), Positives = 24/33 (72%), Gaps = 2/33 (6%)
 Frame = +2

Query: 344 LAQLVKDS--KHIVVHTGAGISTSAGIPDFRGP 436
           +A+L++    + ++V  GAGIST +GIPDFR P
Sbjct: 101 IAELIRARACQRVLVMVGAGISTPSGIPDFRSP 133


>UniRef50_Q1QTH0 Cluster: Silent information regulator protein Sir2;
           n=2; Oceanospirillales|Rep: Silent information regulator
           protein Sir2 - Chromohalobacter salexigens (strain DSM
           3043 / ATCC BAA-138 / NCIMB13768)
          Length = 242

 Score = 35.5 bits (78), Expect = 1.3
 Identities = 14/26 (53%), Positives = 19/26 (73%)
 Frame = +2

Query: 371 HIVVHTGAGISTSAGIPDFRGPNGVW 448
           H+VV TGAGIS  +G+  FR  +G+W
Sbjct: 8   HLVVLTGAGISAESGLKTFRDGDGLW 33


>UniRef50_A0JXS0 Cluster: Silent information regulator protein Sir2
           precursor; n=11; Actinomycetales|Rep: Silent information
           regulator protein Sir2 precursor - Arthrobacter sp.
           (strain FB24)
          Length = 306

 Score = 35.5 bits (78), Expect = 1.3
 Identities = 13/18 (72%), Positives = 17/18 (94%)
 Frame = +2

Query: 386 TGAGISTSAGIPDFRGPN 439
           TGAG+ST +GIPD+RGP+
Sbjct: 48  TGAGLSTDSGIPDYRGPD 65


>UniRef50_Q4DP02 Cluster: Silent information regulator 2, putative;
           n=4; Trypanosoma|Rep: Silent information regulator 2,
           putative - Trypanosoma cruzi
          Length = 359

 Score = 35.5 bits (78), Expect = 1.3
 Identities = 15/22 (68%), Positives = 18/22 (81%)
 Frame = +2

Query: 374 IVVHTGAGISTSAGIPDFRGPN 439
           I+V  GAGIS +AGIPDFR P+
Sbjct: 32  ILVMAGAGISVAAGIPDFRSPH 53


>UniRef50_A2F8N6 Cluster: Transcriptional regulator, Sir2 family
           protein; n=1; Trichomonas vaginalis G3|Rep:
           Transcriptional regulator, Sir2 family protein -
           Trichomonas vaginalis G3
          Length = 320

 Score = 35.5 bits (78), Expect = 1.3
 Identities = 16/39 (41%), Positives = 27/39 (69%), Gaps = 1/39 (2%)
 Frame = +2

Query: 362 DSKHIVVHTGAGISTSAGIPDFRGPN-GVWTLEKEGKKP 475
           ++K I++ +GAG S ++GIPDFR P  G+++  K+   P
Sbjct: 35  NAKKILIFSGAGTSVASGIPDFRSPKIGLYSQLKKYNLP 73


>UniRef50_P48324 Cluster: Uncharacterized 24.3 kDa protein in
           psbH-rpl11 intergenic region; n=1; Cyanophora
           paradoxa|Rep: Uncharacterized 24.3 kDa protein in
           psbH-rpl11 intergenic region - Cyanophora paradoxa
          Length = 182

 Score = 35.5 bits (78), Expect = 1.3
 Identities = 18/52 (34%), Positives = 33/52 (63%)
 Frame = -3

Query: 305 ISLGLLVYLCFHKVIVLCIIARHFWETIYLMVLTQIFIEPLFKFKLRIFFYN 150
           ISL  L+Y   + + ++  I  HF    YL+VL ++ ++P+F++ + IFF+N
Sbjct: 101 ISLVNLLYKAIYWIYIIFAIFLHFMN--YLLVLLELTLQPIFEW-IEIFFFN 149


>UniRef50_Q9RL35 Cluster: NAD-dependent deacetylase 1; n=8;
           Actinomycetales|Rep: NAD-dependent deacetylase 1 -
           Streptomyces coelicolor
          Length = 299

 Score = 35.5 bits (78), Expect = 1.3
 Identities = 14/23 (60%), Positives = 19/23 (82%)
 Frame = +2

Query: 374 IVVHTGAGISTSAGIPDFRGPNG 442
           ++V +GAGIST +GIPD+RG  G
Sbjct: 34  VLVLSGAGISTESGIPDYRGEGG 56


>UniRef50_Q9I4L0 Cluster: NAD-dependent deacetylase 1; n=10;
           Bacteria|Rep: NAD-dependent deacetylase 1 - Pseudomonas
           aeruginosa
          Length = 250

 Score = 35.5 bits (78), Expect = 1.3
 Identities = 14/36 (38%), Positives = 24/36 (66%), Gaps = 1/36 (2%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGP-NGVW 448
           + +L+  ++ +V+ TGAG+S  +GIP FR    G+W
Sbjct: 4   VVELLAGARRLVIFTGAGVSAESGIPTFRDALGGLW 39


>UniRef50_Q2U9Y7 Cluster: Sirtuin 4 and related class II sirtuins;
           n=10; Pezizomycotina|Rep: Sirtuin 4 and related class II
           sirtuins - Aspergillus oryzae
          Length = 407

 Score = 35.1 bits (77), Expect = 1.7
 Identities = 14/28 (50%), Positives = 20/28 (71%)
 Frame = +2

Query: 377 VVHTGAGISTSAGIPDFRGPNGVWTLEK 460
           V+ TGAGIS ++G+ D+RG NG +   K
Sbjct: 85  VLLTGAGISVASGLSDYRGENGTYVTNK 112


>UniRef50_P53686 Cluster: NAD-dependent deacetylase HST2; n=4;
           Saccharomyces cerevisiae|Rep: NAD-dependent deacetylase
           HST2 - Saccharomyces cerevisiae (Baker's yeast)
          Length = 357

 Score = 35.1 bits (77), Expect = 1.7
 Identities = 14/21 (66%), Positives = 16/21 (76%)
 Frame = +2

Query: 374 IVVHTGAGISTSAGIPDFRGP 436
           ++   GAGISTS GIPDFR P
Sbjct: 27  VIFMVGAGISTSCGIPDFRSP 47


>UniRef50_Q6AF12 Cluster: Regulatory protein, Sir2 family; n=2;
           Actinobacteria (class)|Rep: Regulatory protein, Sir2
           family - Leifsonia xyli subsp. xyli
          Length = 283

 Score = 34.7 bits (76), Expect = 2.2
 Identities = 14/26 (53%), Positives = 18/26 (69%)
 Frame = +2

Query: 356 VKDSKHIVVHTGAGISTSAGIPDFRG 433
           V   +   V TGAG+ST +GIPD+RG
Sbjct: 24  VLSGRRFAVLTGAGVSTDSGIPDYRG 49


>UniRef50_Q5P3W1 Cluster: NAD-dependent deacetylase 2; n=4;
           Proteobacteria|Rep: NAD-dependent deacetylase 2 -
           Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum
           (strain EbN1))
          Length = 260

 Score = 34.7 bits (76), Expect = 2.2
 Identities = 14/35 (40%), Positives = 24/35 (68%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +A+L+  +  I+  TGAGIS  +G+P +RG  G++
Sbjct: 10  VARLIAGAPRILFITGAGISADSGLPTYRGIGGLY 44


>UniRef50_Q4XD65 Cluster: Putative uncharacterized protein; n=1;
           Plasmodium chabaudi|Rep: Putative uncharacterized
           protein - Plasmodium chabaudi
          Length = 177

 Score = 34.7 bits (76), Expect = 2.2
 Identities = 26/100 (26%), Positives = 52/100 (52%)
 Frame = -3

Query: 530 FKIIWVFGVVHQQMIH*WLAFYLPSLKSTLHLAL*SLEYPQKYLCQLQCGQQYVYYLSQV 351
           +  +W +  ++ + I+  L+ YL S+  ++H+++    Y  KYL    C   Y+ YLS  
Sbjct: 2   YLFVWRYIYIYIKSIY--LSIYL-SIYLSIHISI----YLSKYLSMYLCIYPYIIYLSS- 53

Query: 350 EPRVHISGSVCHLNQISLGLLVYLCFHKVIVLCIIARHFW 231
               ++S S+     +S+ L ++L  H  I L I++ +F+
Sbjct: 54  ----YLSMSIYLSIYLSIYLSIFLSIHPSIYLSILSVYFF 89


>UniRef50_A2DKY5 Cluster: Transcriptional regulator, Sir2 family
           protein; n=1; Trichomonas vaginalis G3|Rep:
           Transcriptional regulator, Sir2 family protein -
           Trichomonas vaginalis G3
          Length = 180

 Score = 34.7 bits (76), Expect = 2.2
 Identities = 17/36 (47%), Positives = 24/36 (66%), Gaps = 2/36 (5%)
 Frame = +2

Query: 323 LNQKCVLLAQLVKDS--KHIVVHTGAGISTSAGIPD 424
           +NQ   +LA L+K    K++VV TG+GI  + GIPD
Sbjct: 1   MNQNISVLANLLKSGNYKNVVVMTGSGICNACGIPD 36


>UniRef50_A5DW75 Cluster: Putative uncharacterized protein; n=1;
           Lodderomyces elongisporus NRRL YB-4239|Rep: Putative
           uncharacterized protein - Lodderomyces elongisporus
           (Yeast) (Saccharomyces elongisporus)
          Length = 379

 Score = 34.7 bits (76), Expect = 2.2
 Identities = 14/27 (51%), Positives = 18/27 (66%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGPNGVW 448
           K IV   GAG+  S+G+P FRG  G+W
Sbjct: 16  KKIVALVGAGLLASSGLPVFRGSQGLW 42


>UniRef50_A2QUR5 Cluster: Remark: the H. sapiens SIRT4 belongs to a
           group of four human SIRT proteins; n=1; Aspergillus
           niger|Rep: Remark: the H. sapiens SIRT4 belongs to a
           group of four human SIRT proteins - Aspergillus niger
          Length = 357

 Score = 34.7 bits (76), Expect = 2.2
 Identities = 14/28 (50%), Positives = 20/28 (71%)
 Frame = +2

Query: 377 VVHTGAGISTSAGIPDFRGPNGVWTLEK 460
           V+ TGAGIS ++G+ D+RG NG +   K
Sbjct: 58  VLLTGAGISVASGLSDYRGENGTYITNK 85


>UniRef50_Q8F3Z6 Cluster: NAD-dependent deacetylase; n=4;
           Leptospira|Rep: NAD-dependent deacetylase - Leptospira
           interrogans
          Length = 246

 Score = 34.7 bits (76), Expect = 2.2
 Identities = 13/21 (61%), Positives = 16/21 (76%)
 Frame = +2

Query: 386 TGAGISTSAGIPDFRGPNGVW 448
           +GAGIS  +GIP FRG  G+W
Sbjct: 19  SGAGISAESGIPTFRGSEGLW 39


>UniRef50_Q4APN6 Cluster: Silent information regulator protein Sir2;
           n=1; Chlorobium phaeobacteroides BS1|Rep: Silent
           information regulator protein Sir2 - Chlorobium
           phaeobacteroides BS1
          Length = 217

 Score = 34.3 bits (75), Expect = 2.9
 Identities = 11/21 (52%), Positives = 16/21 (76%)
 Frame = +2

Query: 386 TGAGISTSAGIPDFRGPNGVW 448
           TGAG+S  +G+P +RG  G+W
Sbjct: 4   TGAGMSAESGVPTYRGKGGIW 24


>UniRef50_A6Q946 Cluster: Transcriptional regulator, Sir2 family;
           n=1; Sulfurovum sp. NBC37-1|Rep: Transcriptional
           regulator, Sir2 family - Sulfurovum sp. (strain NBC37-1)
          Length = 271

 Score = 34.3 bits (75), Expect = 2.9
 Identities = 11/33 (33%), Positives = 21/33 (63%)
 Frame = +2

Query: 350 QLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           +++ ++  + +  GAG+   +G+PDFRG  G W
Sbjct: 11  KVLNETDALFIMAGAGMGVDSGLPDFRGVEGFW 43


>UniRef50_A3WK56 Cluster: SIR2-like regulatory protein,
           NAD-dependent protein deacetylase; n=1; Idiomarina
           baltica OS145|Rep: SIR2-like regulatory protein,
           NAD-dependent protein deacetylase - Idiomarina baltica
           OS145
          Length = 279

 Score = 34.3 bits (75), Expect = 2.9
 Identities = 14/37 (37%), Positives = 23/37 (62%)
 Frame = +2

Query: 338 VLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           V  A+L++ +    + +GAG+ST +GIP +R   G W
Sbjct: 9   VKAAELLRGNTPFTLLSGAGLSTDSGIPAYRNAQGQW 45


>UniRef50_Q54LF0 Cluster: Ankyrin repeat-containing protein; n=1;
           Dictyostelium discoideum AX4|Rep: Ankyrin
           repeat-containing protein - Dictyostelium discoideum AX4
          Length = 778

 Score = 34.3 bits (75), Expect = 2.9
 Identities = 14/32 (43%), Positives = 23/32 (71%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGPNGVWTLEKE 463
           K+++V +GAGIS +AGIP +R  +G+    K+
Sbjct: 489 KNVIVLSGAGISANAGIPPYRTKDGLLAKNKQ 520


>UniRef50_Q17JQ3 Cluster: Mitochondrial ribosomal protein, S34,
           putative; n=3; Endopterygota|Rep: Mitochondrial
           ribosomal protein, S34, putative - Aedes aegypti
           (Yellowfever mosquito)
          Length = 182

 Score = 34.3 bits (75), Expect = 2.9
 Identities = 15/29 (51%), Positives = 19/29 (65%)
 Frame = +2

Query: 431 GPNGVWTLEKEGKKPTINVSFADAQPQKP 517
           G N V+ L KEG+KPTI+VS    +P  P
Sbjct: 146 GHNNVYRLAKEGEKPTIDVSMGLGKPASP 174


>UniRef50_Q7S223 Cluster: Putative uncharacterized protein
           NCU05973.1; n=1; Neurospora crassa|Rep: Putative
           uncharacterized protein NCU05973.1 - Neurospora crassa
          Length = 334

 Score = 34.3 bits (75), Expect = 2.9
 Identities = 14/43 (32%), Positives = 25/43 (58%)
 Frame = +2

Query: 320 KLNQKCVLLAQLVKDSKHIVVHTGAGISTSAGIPDFRGPNGVW 448
           ++N       +L K  + + +  GAG+S ++G+P FRG  G+W
Sbjct: 4   RINNLAAFHQKLAKADRILAI-CGAGLSAASGLPTFRGVGGLW 45


>UniRef50_Q2KH01 Cluster: Putative uncharacterized protein; n=2;
           Magnaporthe grisea|Rep: Putative uncharacterized protein
           - Magnaporthe grisea 70-15
          Length = 449

 Score = 34.3 bits (75), Expect = 2.9
 Identities = 23/73 (31%), Positives = 37/73 (50%)
 Frame = +2

Query: 209 VPLDKLSPKNVLQLCKGLSPYENKGILGVPEKFDSNDKLNQKCVLLAQLVKDSKHIVVHT 388
           +P + L  K++ + C   +P  ++     P + D  D +        QL++  +  VV +
Sbjct: 55  LPGNSLLLKDLNRRCAASTPDRSRPSSPQPAEIDLVDAM--------QLLRSHRQTVVFS 106

Query: 389 GAGISTSAGIPDF 427
           GAGIS SAGIP F
Sbjct: 107 GAGISVSAGIPTF 119


>UniRef50_Q25337 Cluster: NAD-dependent deacetylase SIR2 homolog;
           n=6; Leishmania|Rep: NAD-dependent deacetylase SIR2
           homolog - Leishmania major
          Length = 381

 Score = 34.3 bits (75), Expect = 2.9
 Identities = 15/24 (62%), Positives = 18/24 (75%)
 Frame = +2

Query: 359 KDSKHIVVHTGAGISTSAGIPDFR 430
           KD + I+V  GAG S +AGIPDFR
Sbjct: 29  KDVRRILVLVGAGASVAAGIPDFR 52


>UniRef50_Q839C6 Cluster: NAD-dependent deacetylase; n=14;
           Bacilli|Rep: NAD-dependent deacetylase - Enterococcus
           faecalis (Streptococcus faecalis)
          Length = 237

 Score = 34.3 bits (75), Expect = 2.9
 Identities = 13/21 (61%), Positives = 18/21 (85%)
 Frame = +2

Query: 386 TGAGISTSAGIPDFRGPNGVW 448
           TGAGIST++G+PD+R   GV+
Sbjct: 23  TGAGISTASGVPDYRSLKGVY 43


>UniRef50_Q8A3H9 Cluster: NAD-dependent deacetylase; n=3;
           Bacteroides|Rep: NAD-dependent deacetylase - Bacteroides
           thetaiotaomicron
          Length = 234

 Score = 34.3 bits (75), Expect = 2.9
 Identities = 14/27 (51%), Positives = 19/27 (70%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGPNGVW 448
           K++VV TGAG+S  +GI  FR   G+W
Sbjct: 2   KNLVVLTGAGMSAESGISTFRDAGGLW 28


>UniRef50_A6FYM4 Cluster: Sir2 family protein; n=1; Plesiocystis
           pacifica SIR-1|Rep: Sir2 family protein - Plesiocystis
           pacifica SIR-1
          Length = 297

 Score = 33.9 bits (74), Expect = 3.9
 Identities = 16/30 (53%), Positives = 21/30 (70%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRG 433
           LA+L    + +V  TGAG ST +GIPD+RG
Sbjct: 27  LAELCA-GRRVVALTGAGCSTESGIPDYRG 55


>UniRef50_A5K7T7 Cluster: NAD-dependent deacetylase, putative; n=5;
           Plasmodium|Rep: NAD-dependent deacetylase, putative -
           Plasmodium vivax
          Length = 306

 Score = 33.9 bits (74), Expect = 3.9
 Identities = 14/37 (37%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
 Frame = +2

Query: 344 LAQLVKDSKHIVVHTGAGISTSAGIPDFRGPN-GVWT 451
           LA +++   ++V  TG+G S  + IP FRG N  +W+
Sbjct: 21  LACMIRGCTYVVALTGSGTSAESNIPSFRGANSSIWS 57


>UniRef50_Q8ZFR1 Cluster: NAD-dependent deacetylase; n=149; cellular
           organisms|Rep: NAD-dependent deacetylase - Yersinia
           pestis
          Length = 278

 Score = 33.9 bits (74), Expect = 3.9
 Identities = 14/25 (56%), Positives = 18/25 (72%)
 Frame = +2

Query: 374 IVVHTGAGISTSAGIPDFRGPNGVW 448
           +VV TGAGIS  +GI  FR  +G+W
Sbjct: 41  VVVLTGAGISAESGIRTFRADDGLW 65


>UniRef50_O25849 Cluster: NAD-dependent deacetylase; n=11;
           Bacteria|Rep: NAD-dependent deacetylase - Helicobacter
           pylori (Campylobacter pylori)
          Length = 229

 Score = 33.9 bits (74), Expect = 3.9
 Identities = 13/27 (48%), Positives = 20/27 (74%)
 Frame = +2

Query: 368 KHIVVHTGAGISTSAGIPDFRGPNGVW 448
           K++V+ +GAGIS  +GI  FR  +G+W
Sbjct: 2   KNLVILSGAGISAESGIKTFRDADGLW 28


  Database: uniref50
    Posted date:  Oct 5, 2007 11:19 AM
  Number of letters in database: 575,637,011
  Number of sequences in database:  1,657,284
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 711,743,914
Number of Sequences: 1657284
Number of extensions: 14796393
Number of successful extensions: 34633
Number of sequences better than 10.0: 261
Number of HSP's better than 10.0 without gapping: 33433
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 34621
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 55371905986
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)

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