Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= wdV40523
(634 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9VQG2 Cluster: Gamma-secretase subunit Aph-1; n=7; End... 113 3e-24
UniRef50_Q96BI3 Cluster: Gamma-secretase subunit APH-1A; n=37; E... 93 4e-18
UniRef50_Q8WW43 Cluster: Gamma-secretase subunit APH-1B; n=21; E... 93 5e-18
UniRef50_A7S9N7 Cluster: Predicted protein; n=2; Eumetazoa|Rep: ... 89 6e-17
UniRef50_A7S9N6 Cluster: Predicted protein; n=1; Nematostella ve... 77 5e-13
UniRef50_Q8C7N7-2 Cluster: Isoform 2 of Q8C7N7 ; n=3; Murinae|Re... 73 4e-12
UniRef50_Q5DBY4 Cluster: SJCHGC06550 protein; n=1; Schistosoma j... 56 9e-07
UniRef50_O45876 Cluster: Gamma-secretase subunit aph-1; n=12; Bi... 39 0.087
UniRef50_Q8L9G7 Cluster: Gamma-secretase subunit APH1-like; n=3;... 38 0.20
UniRef50_Q4Q683 Cluster: Amino acid permease; n=13; Leishmania|R... 36 0.61
UniRef50_Q55FS3 Cluster: Putative uncharacterized protein; n=1; ... 36 0.81
UniRef50_Q1WA84 Cluster: Putative uncharacterized protein; n=1; ... 33 4.3
UniRef50_A0GWY0 Cluster: Hedgehog protein; n=2; Chloroflexus|Rep... 33 4.3
UniRef50_Q8EWP8 Cluster: Predicted cytoskeletal protein; n=1; My... 33 5.7
UniRef50_Q17KQ4 Cluster: Putative uncharacterized protein; n=1; ... 33 7.5
UniRef50_A2DP04 Cluster: Surface antigen BspA-like; n=1; Trichom... 33 7.5
UniRef50_UPI000155CAC6 Cluster: PREDICTED: similar to 5-hydroxyt... 32 10.0
UniRef50_Q6KI57 Cluster: Putative uncharacterized protein; n=1; ... 32 10.0
UniRef50_O25793 Cluster: Multidrug-efflux transporter; n=4; Heli... 32 10.0
UniRef50_A0PFN3 Cluster: Predicted novel alpha-adrenergic-like G... 32 10.0
>UniRef50_Q9VQG2 Cluster: Gamma-secretase subunit Aph-1; n=7;
Endopterygota|Rep: Gamma-secretase subunit Aph-1 -
Drosophila melanogaster (Fruit fly)
Length = 238
Score = 113 bits (272), Expect = 3e-24
Identities = 53/84 (63%), Positives = 65/84 (77%)
Frame = +1
Query: 4 LLRKTEAGLKEISENHEIGSNKLEMAYVSGLGFGTMSGAFALVNVLADSIGPGTLGLSGG 183
+LR TE GL ++E+ + NK +AYVSGLGFG +SG FALVNVLAD GPGT+GL GG
Sbjct: 83 ILRSTEQGLHAVAEDTRVTDNKHILAYVSGLGFGIISGMFALVNVLADMSGPGTMGLKGG 142
Query: 184 TEYFFVTSSAMTLCMILLNTFWSI 255
TE FFVTS+A L +ILL+TFWS+
Sbjct: 143 TELFFVTSAAQALSIILLHTFWSV 166
Score = 72.1 bits (169), Expect = 1e-11
Identities = 31/65 (47%), Positives = 47/65 (72%)
Frame = +3
Query: 255 IFFSGFDEKNYLKILWVIISHFFVSFLSLLNSRELYAASILPSYIGLMITSYNAFRCAGG 434
IFF+ FD NY+ I +V+ SH FVS ++LLN+ ELY ++L +Y+ ++T AFR AGG
Sbjct: 167 IFFNAFDTNNYIHIGYVVFSHLFVSLITLLNANELYTTTLLINYLVTILTGVLAFRVAGG 226
Query: 435 SSKTF 449
+S++F
Sbjct: 227 TSRSF 231
>UniRef50_Q96BI3 Cluster: Gamma-secretase subunit APH-1A; n=37;
Euteleostomi|Rep: Gamma-secretase subunit APH-1A - Homo
sapiens (Human)
Length = 265
Score = 93.5 bits (222), Expect = 4e-18
Identities = 39/84 (46%), Positives = 62/84 (73%)
Frame = +1
Query: 4 LLRKTEAGLKEISENHEIGSNKLEMAYVSGLGFGTMSGAFALVNVLADSIGPGTLGLSGG 183
LL+K + GL +SE+ + +MAYVSGL FG +SG F+++N+LAD++GPG +G+ G
Sbjct: 93 LLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGD 152
Query: 184 TEYFFVTSSAMTLCMILLNTFWSI 255
+ Y+F+TS+ +T +ILL+TFW +
Sbjct: 153 SPYYFLTSAFLTAAIILLHTFWGV 176
Score = 37.9 bits (84), Expect = 0.20
Identities = 24/72 (33%), Positives = 35/72 (48%)
Frame = +3
Query: 255 IFFSGFDEKNYLKILWVIISHFFVSFLSLLNSRELYAASILPSYIGLMITSYNAFRCAGG 434
+FF + + Y + V+ SH S L+ LN Y AS+LP Y + AF AGG
Sbjct: 177 VFFDACERRRYWALGLVVGSHLLTSGLTFLNP--WYEASLLPIYAVTVSMGLWAFITAGG 234
Query: 435 SSKTFIQSFSAR 470
S ++ +S R
Sbjct: 235 SLRSIQRSLLCR 246
>UniRef50_Q8WW43 Cluster: Gamma-secretase subunit APH-1B; n=21;
Euteleostomi|Rep: Gamma-secretase subunit APH-1B - Homo
sapiens (Human)
Length = 257
Score = 93.1 bits (221), Expect = 5e-18
Identities = 45/84 (53%), Positives = 59/84 (70%)
Frame = +1
Query: 4 LLRKTEAGLKEISENHEIGSNKLEMAYVSGLGFGTMSGAFALVNVLADSIGPGTLGLSGG 183
LL+K GLK I+ S +L +AYVSGLGFG MSG F+ VN L+DS+GPGT+G+ G
Sbjct: 93 LLKKASEGLKSINPGETAPSMRL-LAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGD 151
Query: 184 TEYFFVTSSAMTLCMILLNTFWSI 255
+ FF+ S+ MTL +ILL+ FW I
Sbjct: 152 SPQFFLYSAFMTLVIILLHVFWGI 175
>UniRef50_A7S9N7 Cluster: Predicted protein; n=2; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 243
Score = 89.4 bits (212), Expect = 6e-17
Identities = 40/84 (47%), Positives = 58/84 (69%)
Frame = +1
Query: 4 LLRKTEAGLKEISENHEIGSNKLEMAYVSGLGFGTMSGAFALVNVLADSIGPGTLGLSGG 183
++RK + GL + N++ K +AYV+GLG+G MSG FA+VNVLAD GPG++GL G
Sbjct: 84 IIRKADEGLLSMI-NNQSPLRKHRIAYVAGLGYGLMSGLFAMVNVLADISGPGSIGLHGN 142
Query: 184 TEYFFVTSSAMTLCMILLNTFWSI 255
+ F + S+ +T C +LLNTFW +
Sbjct: 143 AQNFLIVSAFLTSCFVLLNTFWGV 166
Score = 57.6 bits (133), Expect = 2e-07
Identities = 25/61 (40%), Positives = 40/61 (65%)
Frame = +3
Query: 255 IFFSGFDEKNYLKILWVIISHFFVSFLSLLNSRELYAASILPSYIGLMITSYNAFRCAGG 434
I+F G++ K +L + V+ SH FVS ++LLN Y A++L +Y L++ + AF+ AGG
Sbjct: 167 IWFDGWENKKWLNVFVVVASHLFVSLMTLLNQDSQYIATLLSAYFTLVVMAVLAFKVAGG 226
Query: 435 S 437
S
Sbjct: 227 S 227
>UniRef50_A7S9N6 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 115
Score = 76.6 bits (180), Expect = 5e-13
Identities = 31/56 (55%), Positives = 42/56 (75%)
Frame = +1
Query: 88 SGLGFGTMSGAFALVNVLADSIGPGTLGLSGGTEYFFVTSSAMTLCMILLNTFWSI 255
+GLG+G MSG FA+VNVLAD GPG++GL G + F + S+ +T C +LLNTFW +
Sbjct: 1 AGLGYGLMSGLFAMVNVLADISGPGSIGLHGNAQNFLIVSAFLTSCFVLLNTFWGV 56
>UniRef50_Q8C7N7-2 Cluster: Isoform 2 of Q8C7N7 ; n=3; Murinae|Rep:
Isoform 2 of Q8C7N7 - Mus musculus (Mouse)
Length = 212
Score = 73.3 bits (172), Expect = 4e-12
Identities = 36/80 (45%), Positives = 53/80 (66%)
Frame = +1
Query: 4 LLRKTEAGLKEISENHEIGSNKLEMAYVSGLGFGTMSGAFALVNVLADSIGPGTLGLSGG 183
LL+K GLK I+ S +L +AYVSGLGFG MSG F+ VN L++S+GPGT+G+ G
Sbjct: 93 LLKKASEGLKSINPEETAPSMRL-LAYVSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGD 151
Query: 184 TEYFFVTSSAMTLCMILLNT 243
+ FF+ S ++ + +N+
Sbjct: 152 SPQFFLNSVRISASPMDINS 171
>UniRef50_Q5DBY4 Cluster: SJCHGC06550 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC06550 protein - Schistosoma
japonicum (Blood fluke)
Length = 313
Score = 55.6 bits (128), Expect = 9e-07
Identities = 28/82 (34%), Positives = 46/82 (56%), Gaps = 1/82 (1%)
Frame = +1
Query: 40 SENHEIGSNKLEMAYVSGLGFGTMSGAFALVNVLADSIGPGTLGLS-GGTEYFFVTSSAM 216
+ N+ + + +AYVSGLG+G MS L+ +L DS GPG S ++ FF+ +S
Sbjct: 163 NNNNIVQLDHRTVAYVSGLGYGLMSCIIQLLRILIDSYGPGIFMYSTWDSKTFFLFASCQ 222
Query: 217 TLCMILLNTFWSIYSLVVLMKR 282
+C+ +L FWS+ ++R
Sbjct: 223 CMCISMLQVFWSLILFTGFVQR 244
Score = 39.9 bits (89), Expect = 0.050
Identities = 25/87 (28%), Positives = 40/87 (45%), Gaps = 5/87 (5%)
Frame = +3
Query: 177 WWDRILFCDKFCNDSLYDTTQHILEYIFFSGFDEKNYLKILWVIISHFFVSFLSLLNS-- 350
W + F C Q I F+GF ++ Y +I++V HF ++ LSL+N+
Sbjct: 210 WDSKTFFLFASCQCMCISMLQVFWSLILFTGFVQRVYSQIIFVYSMHFGLAALSLINTFP 269
Query: 351 ---RELYAASILPSYIGLMITSYNAFR 422
E+ + IG+MI +Y FR
Sbjct: 270 SPCPEIVCTVYMACLIGMMILAYFRFR 296
>UniRef50_O45876 Cluster: Gamma-secretase subunit aph-1; n=12;
Bilateria|Rep: Gamma-secretase subunit aph-1 -
Caenorhabditis elegans
Length = 308
Score = 39.1 bits (87), Expect = 0.087
Identities = 25/67 (37%), Positives = 36/67 (53%), Gaps = 9/67 (13%)
Frame = +1
Query: 1 LLLRKTEAGLKEISENHEI----GSNKLE-----MAYVSGLGFGTMSGAFALVNVLADSI 153
+LL+K + GL +I+ +I G + L +A V GLG G +S F +N A
Sbjct: 84 MLLKKAQRGLNKITRQGQISVAPGVSDLHNARHMLALVCGLGMGVISALFYTMNAFAIFS 143
Query: 154 GPGTLGL 174
GPGT+GL
Sbjct: 144 GPGTIGL 150
>UniRef50_Q8L9G7 Cluster: Gamma-secretase subunit APH1-like; n=3;
Magnoliophyta|Rep: Gamma-secretase subunit APH1-like -
Arabidopsis thaliana (Mouse-ear cress)
Length = 250
Score = 37.9 bits (84), Expect = 0.20
Identities = 18/63 (28%), Positives = 35/63 (55%), Gaps = 1/63 (1%)
Frame = +1
Query: 61 SNKLEMAYVSGLGFGTMSGAFALVNVLADSIGPGTLGLSGGTEY-FFVTSSAMTLCMILL 237
++KL++A GLG G F +++L + GP T + ++ FF+ S+ + L + +
Sbjct: 111 TDKLQIALAGGLGHGVAHAVFFCLSLLTPAFGPATFYVERCSKVPFFLISAIIALAFVTI 170
Query: 238 NTF 246
+TF
Sbjct: 171 HTF 173
>UniRef50_Q4Q683 Cluster: Amino acid permease; n=13; Leishmania|Rep:
Amino acid permease - Leishmania major
Length = 605
Score = 36.3 bits (80), Expect = 0.61
Identities = 24/59 (40%), Positives = 36/59 (61%), Gaps = 2/59 (3%)
Frame = +1
Query: 103 GTMSGAFALVNVLADSIGPGTLGLSGGTEYFFVTSSAMTLCMILLN--TFWSIYSLVVL 273
G +SGAF N+ + SIG G LGL T+ S+ + L MILL T++S++S+ +L
Sbjct: 87 GILSGAF---NMASSSIGAGILGLPAATD-----SAGIILAMILLAVITYFSVFSMYIL 137
>UniRef50_Q55FS3 Cluster: Putative uncharacterized protein; n=1;
Dictyostelium discoideum AX4|Rep: Putative
uncharacterized protein - Dictyostelium discoideum AX4
Length = 328
Score = 35.9 bits (79), Expect = 0.81
Identities = 16/44 (36%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Frame = +3
Query: 219 SLYDTTQHILEYIF-FSGFDEKNYLKILWVIISHFFVSFLSLLN 347
+L+ T H++ + F G+ K Y + +VII+HF ++L+LLN
Sbjct: 245 TLFMTLLHVVYNVLAFQGYRSKKYHLVAFVIITHFVTTYLTLLN 288
Score = 32.3 bits (70), Expect = 10.0
Identities = 19/56 (33%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Frame = +1
Query: 91 GLGFGTMSGAFALVNVLADSIGPGTL-GLSGGTEYFFVTSSAMTLCMILLNTFWSI 255
G+G G G ++L +S GPGTL + + F+ SS +TL M LL+ +++
Sbjct: 202 GVGSGVAYGFIMFGSILWESTGPGTLFSPACPSVNLFMLSSIITLFMTLLHVVYNV 257
>UniRef50_Q1WA84 Cluster: Putative uncharacterized protein; n=1;
Ictalurus punctatus|Rep: Putative uncharacterized
protein - Ictalurus punctatus (Channel catfish)
Length = 76
Score = 33.5 bits (73), Expect = 4.3
Identities = 12/21 (57%), Positives = 17/21 (80%)
Frame = +1
Query: 193 FFVTSSAMTLCMILLNTFWSI 255
+F+TS+ MTL M LL+TFW +
Sbjct: 1 YFITSALMTLAMTLLHTFWGV 21
>UniRef50_A0GWY0 Cluster: Hedgehog protein; n=2; Chloroflexus|Rep:
Hedgehog protein - Chloroflexus aggregans DSM 9485
Length = 314
Score = 33.5 bits (73), Expect = 4.3
Identities = 14/36 (38%), Positives = 21/36 (58%)
Frame = -3
Query: 203 VTKKYSVPPLRPNVPGPIESANTLTSANAPLIVPNP 96
V S+ PL P VP P+ ++ T+T +P I P+P
Sbjct: 149 VVSPTSLSPLTPTVPVPVTASPTMTLTPSPTITPSP 184
>UniRef50_Q8EWP8 Cluster: Predicted cytoskeletal protein; n=1;
Mycoplasma penetrans|Rep: Predicted cytoskeletal protein
- Mycoplasma penetrans
Length = 3317
Score = 33.1 bits (72), Expect = 5.7
Identities = 16/65 (24%), Positives = 36/65 (55%)
Frame = -1
Query: 265 LKNIYSRMC*VVSYKESLQNLSQKSILSHHSGLMCQGQSSQLIH*LVQMLHSLFRILGQT 86
LKNIYS+ +V++ N ++ + + L+C SSQL++ ++ L ++ + + ++
Sbjct: 2937 LKNIYSQKVKLVNFLADSSNEDVNCLVEYKASLLCDDLSSQLVNEQLKDLENVIKKIDES 2996
Query: 85 HKPSL 71
+ L
Sbjct: 2997 YLKEL 3001
>UniRef50_Q17KQ4 Cluster: Putative uncharacterized protein; n=1;
Aedes aegypti|Rep: Putative uncharacterized protein -
Aedes aegypti (Yellowfever mosquito)
Length = 658
Score = 32.7 bits (71), Expect = 7.5
Identities = 15/29 (51%), Positives = 17/29 (58%)
Frame = -3
Query: 191 YSVPPLRPNVPGPIESANTLTSANAPLIV 105
YS P P PG IES N LTS N P ++
Sbjct: 433 YSTDPSPPPTPGLIESFNQLTSPNLPPVI 461
>UniRef50_A2DP04 Cluster: Surface antigen BspA-like; n=1;
Trichomonas vaginalis G3|Rep: Surface antigen BspA-like
- Trichomonas vaginalis G3
Length = 727
Score = 32.7 bits (71), Expect = 7.5
Identities = 21/73 (28%), Positives = 32/73 (43%)
Frame = -3
Query: 281 LFIKTTKEYILQNVLSSIIQRVIAELVTKKYSVPPLRPNVPGPIESANTLTSANAPLIVP 102
+F+ TTKEY L IQ+ + + + P P P+ T AP P
Sbjct: 610 IFVYTTKEYKENTFLGHPIQQKLDQCTDTPPNPPAPTALPPTPVTPEPTKAPTVAP-YTP 668
Query: 101 NPRPDT*AISSLL 63
P+PDT + S ++
Sbjct: 669 TPKPDTPSSSKVM 681
>UniRef50_UPI000155CAC6 Cluster: PREDICTED: similar to
5-hydroxytryptamine 1A receptor (5-HT-1A) (Serotonin
receptor 1A) (5-HT1A); n=1; Ornithorhynchus
anatinus|Rep: PREDICTED: similar to 5-hydroxytryptamine
1A receptor (5-HT-1A) (Serotonin receptor 1A) (5-HT1A) -
Ornithorhynchus anatinus
Length = 440
Score = 32.3 bits (70), Expect = 10.0
Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 1/56 (1%)
Frame = +1
Query: 124 ALVNVLAD-SIGPGTLGLSGGTEYFFVTSSAMTLCMILLNTFWSIYSLVVLMKRTT 288
AL VL ++GP L + TSS + LC I L+ +W++ V ++R T
Sbjct: 162 ALYQVLGRWTLGPAACDLFISLDVLCCTSSILHLCAIALDRYWAVTEPVAYVRRRT 217
>UniRef50_Q6KI57 Cluster: Putative uncharacterized protein; n=1;
Mycoplasma mobile|Rep: Putative uncharacterized protein
- Mycoplasma mobile
Length = 111
Score = 32.3 bits (70), Expect = 10.0
Identities = 11/45 (24%), Positives = 26/45 (57%), Gaps = 2/45 (4%)
Frame = +3
Query: 267 GFDEKNYLKILWVIISHF--FVSFLSLLNSRELYAASILPSYIGL 395
G K YL+ W++ H+ F +++S+ +Y+ +L +++G+
Sbjct: 11 GSSFKKYLRFFWIVFFHYFCFFAYVSIFRFYSIYSIFVLNTFVGV 55
>UniRef50_O25793 Cluster: Multidrug-efflux transporter; n=4;
Helicobacter|Rep: Multidrug-efflux transporter -
Helicobacter pylori (Campylobacter pylori)
Length = 443
Score = 32.3 bits (70), Expect = 10.0
Identities = 13/42 (30%), Positives = 27/42 (64%), Gaps = 1/42 (2%)
Frame = +1
Query: 115 GAFALVN-VLADSIGPGTLGLSGGTEYFFVTSSAMTLCMILL 237
GAF ++ ++ +IGPG + GG ++ F+ ++ +TL +L+
Sbjct: 132 GAFIFISFTISMAIGPGVVAFLGGAKWLFLLTAILTLLSLLM 173
>UniRef50_A0PFN3 Cluster: Predicted novel alpha-adrenergic-like
G-protein coupled receptor; n=3; Branchiostoma
floridae|Rep: Predicted novel alpha-adrenergic-like
G-protein coupled receptor - Branchiostoma floridae
(Florida lancelet) (Amphioxus)
Length = 476
Score = 32.3 bits (70), Expect = 10.0
Identities = 14/39 (35%), Positives = 22/39 (56%)
Frame = +1
Query: 187 EYFFVTSSAMTLCMILLNTFWSIYSLVVLMKRTT*KFSG 303
+ F T+S + LCMI ++ +WS+ V K T K +G
Sbjct: 107 DVFACTASILNLCMISVDRYWSVTQAVQYFKNTNSKRAG 145
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 630,839,228
Number of Sequences: 1657284
Number of extensions: 13213909
Number of successful extensions: 35791
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 34436
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 35743
length of database: 575,637,011
effective HSP length: 97
effective length of database: 414,880,463
effective search space used: 46881492319
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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