Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= wdV11021
(707 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI0000DB7680 Cluster: PREDICTED: similar to Nicastrin ... 94 3e-18
UniRef50_UPI00015B504E Cluster: PREDICTED: similar to Nicastrin ... 81 2e-14
UniRef50_UPI0000D5652A Cluster: PREDICTED: similar to Nicastrin ... 78 2e-13
UniRef50_Q9VC27 Cluster: Nicastrin homolog precursor; n=9; Dipte... 78 2e-13
UniRef50_A7SD25 Cluster: Predicted protein; n=1; Nematostella ve... 69 1e-10
UniRef50_Q92542 Cluster: Nicastrin precursor; n=54; Euteleostomi... 59 1e-07
UniRef50_UPI0000E48526 Cluster: PREDICTED: similar to nicastrin;... 55 2e-06
UniRef50_Q23316 Cluster: Nicastrin precursor; n=3; Caenorhabditi... 42 0.011
UniRef50_UPI0000F21E4B Cluster: PREDICTED: hypothetical protein;... 39 0.10
UniRef50_Q54JT7 Cluster: Putative uncharacterized protein; n=1; ... 38 0.24
UniRef50_Q5C3V5 Cluster: SJCHGC05348 protein; n=1; Schistosoma j... 35 2.3
>UniRef50_UPI0000DB7680 Cluster: PREDICTED: similar to Nicastrin
precursor; n=1; Apis mellifera|Rep: PREDICTED: similar
to Nicastrin precursor - Apis mellifera
Length = 581
Score = 93.9 bits (223), Expect = 3e-18
Identities = 43/81 (53%), Positives = 60/81 (74%)
Frame = +3
Query: 12 RSLCSIQLNSFMFAAINTEVCMRRSATSTIVTTTKVCDPLGDQNVYYSLFPRTKESKKQS 191
R LC++++ SFMFAAIN+E C++RS T+ CDPLGD+N+Y+ L P K++ S
Sbjct: 164 RPLCALEMKSFMFAAINSESCIKRSDFKLNFNPTQFCDPLGDRNIYWPLAPINKDN--NS 221
Query: 192 ITLVTARIDSASLFDGVSPGA 254
I LV AR+D++SLFDG+SPGA
Sbjct: 222 IILVIARLDASSLFDGISPGA 242
Score = 50.0 bits (114), Expect = 6e-05
Identities = 23/49 (46%), Positives = 32/49 (65%)
Frame = +2
Query: 335 LYETNILWTLFNGEAFDYIGSQRVAYDIKRGVWPPNAPLAPTDVKLHVE 481
L TN+++ L NGEAFDYIGS R+ YD+K V + P PT ++ +E
Sbjct: 268 LNNTNVVFALLNGEAFDYIGSSRLIYDLKEDVMENSVP--PTSIQSFLE 314
>UniRef50_UPI00015B504E Cluster: PREDICTED: similar to Nicastrin
homolog; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to Nicastrin homolog - Nasonia vitripennis
Length = 640
Score = 81.4 bits (192), Expect = 2e-14
Identities = 37/81 (45%), Positives = 57/81 (70%)
Frame = +3
Query: 12 RSLCSIQLNSFMFAAINTEVCMRRSATSTIVTTTKVCDPLGDQNVYYSLFPRTKESKKQS 191
RSLC+I++ SFMFAA+N+E C+RRS +S CDPLGD+N+++ + P T K +
Sbjct: 189 RSLCAIEMKSFMFAALNSESCIRRSTSSINFNPNVFCDPLGDRNIHWPVGPITDNVK--N 246
Query: 192 ITLVTARIDSASLFDGVSPGA 254
+ +V AR+D+ SL++ + PGA
Sbjct: 247 VIMVIARLDANSLYENLVPGA 267
Score = 47.2 bits (107), Expect = 4e-04
Identities = 21/53 (39%), Positives = 34/53 (64%), Gaps = 2/53 (3%)
Frame = +2
Query: 344 TNILWTLFNGEAFDYIGSQRVAYDIKRGVWPP--NAPLAPTDVKLHVEIGQIG 496
TN++++L NGE+ DYIGS ++ YD+K G + N L + +E+GQ+G
Sbjct: 294 TNVVFSLLNGESMDYIGSSKLVYDLKEGTFRSLGNKLLKFEQISHVIELGQVG 346
>UniRef50_UPI0000D5652A Cluster: PREDICTED: similar to Nicastrin
homolog precursor; n=1; Tribolium castaneum|Rep:
PREDICTED: similar to Nicastrin homolog precursor -
Tribolium castaneum
Length = 676
Score = 78.2 bits (184), Expect = 2e-13
Identities = 38/84 (45%), Positives = 55/84 (65%), Gaps = 6/84 (7%)
Frame = +3
Query: 3 KRGRSLCSIQLNSFMFAAINTEVCMRRSATSTIVTTTKVCDPLGDQNVYYSLFP------ 164
+R RSLCS+QL SFM+AA N+ C+RRS T + + CDPLGDQNV+ +L+P
Sbjct: 189 QRDRSLCSLQLLSFMYAATNSSTCIRRSNAFTNLNPVRFCDPLGDQNVWAALYPLVKGAN 248
Query: 165 RTKESKKQSITLVTARIDSASLFD 236
T+ ++ +V AR+D+ S+FD
Sbjct: 249 LTEPNRNAKYIIVGARLDTTSMFD 272
Score = 55.2 bits (127), Expect = 1e-06
Identities = 25/69 (36%), Positives = 42/69 (60%), Gaps = 5/69 (7%)
Frame = +2
Query: 323 SKSNLYETNILWTLFNGEAFDYIGSQRVAYDIKRGVWPPNA-----PLAPTDVKLHVEIG 487
+ N YE N+L+ +FNGE +DYIGSQR Y++ RG +P + + D+ L VE+
Sbjct: 299 TNDNNYEKNVLFVIFNGETYDYIGSQRFVYELLRGKFPAKSGDYLPEITIDDIDLFVELS 358
Query: 488 QIGGSLSIM 514
Q+ + +++
Sbjct: 359 QLNWTETVV 367
>UniRef50_Q9VC27 Cluster: Nicastrin homolog precursor; n=9;
Diptera|Rep: Nicastrin homolog precursor - Drosophila
melanogaster (Fruit fly)
Length = 695
Score = 78.2 bits (184), Expect = 2e-13
Identities = 40/90 (44%), Positives = 60/90 (66%), Gaps = 8/90 (8%)
Frame = +3
Query: 12 RSLCSIQLNSFMFAAINTEVCMRRSATSTIVTTTKVCDPLGDQNVYYSLFPRTK--ESKK 185
RSLC++++ SFM AA+NTEVCMRR+ + +K CDPL +NVY +L+PR E+
Sbjct: 199 RSLCAVEVKSFMSAAVNTEVCMRRTNFINNLGGSKYCDPLEGRNVYATLYPRKPAIENNL 258
Query: 186 QSI------TLVTARIDSASLFDGVSPGAL 257
+++ LVT R+D+ ++FDGV GA+
Sbjct: 259 ETVHTNEKFILVTCRLDTTTMFDGVGLGAM 288
Score = 50.0 bits (114), Expect = 6e-05
Identities = 28/80 (35%), Positives = 48/80 (60%), Gaps = 4/80 (5%)
Frame = +2
Query: 308 QLIPVSKSNLYETNILWTLFNGEAFDYIGSQRVAYDIKRGVWPPNA----PLAPTDVKLH 475
QL+P +L+ N+L+ FNGE++DYIGSQR YD+++ +P + P+A ++
Sbjct: 306 QLLPPQSKDLH--NVLFVTFNGESYDYIGSQRFVYDMEKLQFPTESTGTPPIAFDNIDFM 363
Query: 476 VEIGQIGGSLSIM*TKIHGL 535
++IG + +I K+H L
Sbjct: 364 LDIGTLDDISNI---KLHAL 380
>UniRef50_A7SD25 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 991
Score = 68.9 bits (161), Expect = 1e-10
Identities = 33/79 (41%), Positives = 48/79 (60%)
Frame = +3
Query: 18 LCSIQLNSFMFAAINTEVCMRRSATSTIVTTTKVCDPLGDQNVYYSLFPRTKESKKQSIT 197
LCS QL FMFAA +T CMR++ T CDPLGD N++ +L+P + ++ I
Sbjct: 204 LCSAQLKDFMFAAKDTPTCMRKTNIPN-PTQNMFCDPLGDLNIWSTLYPMNRTPNEKEIV 262
Query: 198 LVTARIDSASLFDGVSPGA 254
+V A++DS+S F + GA
Sbjct: 263 VVAAKMDSSSFFHDLVYGA 281
Score = 47.6 bits (108), Expect = 3e-04
Identities = 18/38 (47%), Positives = 30/38 (78%)
Frame = +2
Query: 350 ILWTLFNGEAFDYIGSQRVAYDIKRGVWPPNAPLAPTD 463
I++ LF+GE++DYIGS R+ Y++++G++PPN P D
Sbjct: 314 IMFVLFHGESWDYIGSSRMVYEMEQGLFPPNPWKVPGD 351
>UniRef50_Q92542 Cluster: Nicastrin precursor; n=54;
Euteleostomi|Rep: Nicastrin precursor - Homo sapiens
(Human)
Length = 709
Score = 58.8 bits (136), Expect = 1e-07
Identities = 37/84 (44%), Positives = 48/84 (57%), Gaps = 5/84 (5%)
Frame = +3
Query: 18 LCSIQLNSFMFAAINTEVCMRRSATSTI--VTTTKVCDPLGDQNVYYSLFP-RTKESKKQ 188
LC++QL S M A I+T CMRRS+ + + VCDPL D NV+ L P T + K
Sbjct: 212 LCAMQLFSHMHAVISTATCMRRSSIQSTFSINPEIVCDPLSDYNVWSMLKPINTTGTLKP 271
Query: 189 SITLVTA--RIDSASLFDGVSPGA 254
+V A R+DS S F V+PGA
Sbjct: 272 DDRVVVAATRLDSRSFFWNVAPGA 295
Score = 45.2 bits (102), Expect = 0.002
Identities = 20/49 (40%), Positives = 32/49 (65%)
Frame = +2
Query: 347 NILWTLFNGEAFDYIGSQRVAYDIKRGVWPPNAPLAPTDVKLHVEIGQI 493
N+++ F GE FDYIGS R+ YD+++G + P+ +V VE+GQ+
Sbjct: 324 NVMFVFFQGETFDYIGSSRMVYDMEKGKF----PVQLENVDSFVELGQV 368
>UniRef50_UPI0000E48526 Cluster: PREDICTED: similar to nicastrin;
n=2; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to nicastrin - Strongylocentrotus purpuratus
Length = 713
Score = 54.8 bits (126), Expect = 2e-06
Identities = 27/73 (36%), Positives = 43/73 (58%), Gaps = 2/73 (2%)
Frame = +3
Query: 21 CSIQLNSFMFAAINTEVCMRRSATSTIVTTTKVCDPLGDQNVYYSLFPRTKES--KKQSI 194
C+ ++ FMF A +T CM R+ T + ++ CDPLGD NV+ +L P K + +S+
Sbjct: 218 CAGEMYDFMFGAKDTPTCMWRTQRMTNLESSVYCDPLGDWNVWATLLPTNKSTPPPDKSM 277
Query: 195 TLVTARIDSASLF 233
+ A++D A LF
Sbjct: 278 IIAAAQLDIADLF 290
Score = 48.4 bits (110), Expect = 2e-04
Identities = 17/31 (54%), Positives = 26/31 (83%)
Frame = +2
Query: 344 TNILWTLFNGEAFDYIGSQRVAYDIKRGVWP 436
TNI++T F GE++DYIGS R+ YD+ +G++P
Sbjct: 328 TNIMFTFFQGESYDYIGSSRMVYDMNKGIFP 358
>UniRef50_Q23316 Cluster: Nicastrin precursor; n=3;
Caenorhabditis|Rep: Nicastrin precursor - Caenorhabditis
elegans
Length = 723
Score = 42.3 bits (95), Expect = 0.011
Identities = 22/64 (34%), Positives = 33/64 (51%), Gaps = 8/64 (12%)
Frame = +2
Query: 329 SNLYETNILWTLFNGEAFDYIGSQRVAYDIKRGVWPPNA--------PLAPTDVKLHVEI 484
SN N+ + FNGE+ DYIGS AY ++ G +P P+ P ++ +E+
Sbjct: 327 SNTSNRNVFFAFFNGESLDYIGSGAAAYQMENGKFPQMIRSDRTHIHPIRPNELDYILEV 386
Query: 485 GQIG 496
QIG
Sbjct: 387 QQIG 390
>UniRef50_UPI0000F21E4B Cluster: PREDICTED: hypothetical protein;
n=1; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 301
Score = 39.1 bits (87), Expect = 0.10
Identities = 21/72 (29%), Positives = 36/72 (50%), Gaps = 6/72 (8%)
Frame = +3
Query: 18 LCSIQLNSFMFAAINTEVCMRRSATST--IVTTTKVCDPLGDQNVYYSLFPRTKESK--- 182
LC+++L S A +T CMRR+ + +CDPL D NV+ S+ P ++
Sbjct: 115 LCAMKLFSLKHAVTDTVTCMRRTDLQNKFCINPEILCDPLSDYNVWTSIRPLNNSARGHA 174
Query: 183 -KQSITLVTARI 215
+S+ + R+
Sbjct: 175 ENESVVIAAVRV 186
>UniRef50_Q54JT7 Cluster: Putative uncharacterized protein; n=1;
Dictyostelium discoideum AX4|Rep: Putative
uncharacterized protein - Dictyostelium discoideum AX4
Length = 629
Score = 37.9 bits (84), Expect = 0.24
Identities = 25/74 (33%), Positives = 38/74 (51%)
Frame = +3
Query: 30 QLNSFMFAAINTEVCMRRSATSTIVTTTKVCDPLGDQNVYYSLFPRTKESKKQSITLVTA 209
+L+SFM AIN E C+RR C+P+G Q+++ S +SK I LV
Sbjct: 158 ELDSFMQGAINAETCLRRG----------FCEPVGGQSIWSSFSEVIDQSK--PIILVML 205
Query: 210 RIDSASLFDGVSPG 251
ID+ + F ++ G
Sbjct: 206 PIDATAFFRDLATG 219
>UniRef50_Q5C3V5 Cluster: SJCHGC05348 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC05348 protein - Schistosoma
japonicum (Blood fluke)
Length = 387
Score = 34.7 bits (76), Expect = 2.3
Identities = 16/59 (27%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Frame = +2
Query: 326 KSNLYETNILWTLFNGEAFDYIGSQRVAYDIKRG--VWPPNAPLAPTDVKLHVEIGQIG 496
K + E ++ + + EA+D++GS R++YD+ G P+ +V +E+G++G
Sbjct: 317 KDSHLEKDLFFGFLDNEAYDFMGSYRLSYDLSSGNIARYTGRPVMWNNVHAVIELGEVG 375
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 705,828,598
Number of Sequences: 1657284
Number of extensions: 14198513
Number of successful extensions: 33930
Number of sequences better than 10.0: 11
Number of HSP's better than 10.0 without gapping: 32774
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 33918
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 56611575523
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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