Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= wdS30992
(737 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P07864 Cluster: L-lactate dehydrogenase C chain; n=371;... 175 7e-43
UniRef50_UPI0000519EC7 Cluster: PREDICTED: similar to Ecdysone-i... 143 3e-33
UniRef50_UPI0000DB7268 Cluster: PREDICTED: similar to L-lactate ... 139 8e-32
UniRef50_Q6NPB9 Cluster: AT22132p; n=2; Drosophila melanogaster|... 134 3e-30
UniRef50_Q7NG49 Cluster: L-lactate dehydrogenase; n=4; Cyanobact... 131 2e-29
UniRef50_Q892U0 Cluster: L-lactate dehydrogenase; n=12; Bacteria... 122 1e-26
UniRef50_Q8XP62 Cluster: L-lactate dehydrogenase; n=11; Clostrid... 121 2e-26
UniRef50_UPI0000DB7267 Cluster: PREDICTED: similar to Ecdysone-i... 119 9e-26
UniRef50_P22988 Cluster: L-lactate dehydrogenase A; n=19; Magnol... 118 2e-25
UniRef50_P20619 Cluster: L-lactate dehydrogenase X; n=14; Bacill... 111 2e-23
UniRef50_Q1IRL5 Cluster: L-lactate dehydrogenase; n=6; Bacteria|... 109 5e-23
UniRef50_Q81K80 Cluster: L-lactate dehydrogenase 2; n=12; Firmic... 105 1e-21
UniRef50_UPI00015B6427 Cluster: PREDICTED: similar to lactate de... 102 8e-21
UniRef50_P19869 Cluster: L-lactate dehydrogenase 2; n=17; Bacter... 101 2e-20
UniRef50_Q97DC6 Cluster: L-lactate dehydrogenase 2; n=1; Clostri... 101 2e-20
UniRef50_O51114 Cluster: L-lactate dehydrogenase; n=4; Borrelia ... 98 2e-19
UniRef50_Q4SRH5 Cluster: L-lactate dehydrogenase; n=4; Euteleost... 97 3e-19
UniRef50_Q838C9 Cluster: L-lactate dehydrogenase 2; n=9; Bacilli... 97 4e-19
UniRef50_Q2S4R2 Cluster: L-lactate dehydrogenase; n=1; Salinibac... 95 2e-18
UniRef50_A6M0Q2 Cluster: L-lactate dehydrogenase; n=1; Clostridi... 95 2e-18
UniRef50_A5KJY5 Cluster: Putative uncharacterized protein; n=2; ... 94 3e-18
UniRef50_Q4JY42 Cluster: L-lactate dehydrogenase; n=1; Corynebac... 93 6e-18
UniRef50_P62051 Cluster: L-lactate dehydrogenase; n=2; Desulfovi... 93 9e-18
UniRef50_Q1FID3 Cluster: L-lactate dehydrogenase precursor; n=1;... 90 5e-17
UniRef50_P0A3M9 Cluster: L-lactate dehydrogenase; n=140; Bacteri... 90 5e-17
UniRef50_A3DCA4 Cluster: L-lactate dehydrogenase precursor; n=2;... 84 3e-15
UniRef50_Q6A9C3 Cluster: L-lactate dehydrogenase; n=2; Propionib... 84 3e-15
UniRef50_Q8ELF0 Cluster: L-lactate dehydrogenase; n=5; Bacillace... 84 3e-15
UniRef50_Q81XJ7 Cluster: L-lactate dehydrogenase 3; n=13; Firmic... 84 3e-15
UniRef50_Q3U1V6 Cluster: Ubiquitin-conjugating enzyme E2 variant... 83 7e-15
UniRef50_Q8ZVB2 Cluster: Malate dehydrogenase; n=14; Thermoprote... 83 7e-15
UniRef50_A4QXM2 Cluster: Putative uncharacterized protein; n=1; ... 83 9e-15
UniRef50_Q4L941 Cluster: L-lactate dehydrogenase; n=1; Staphyloc... 82 1e-14
UniRef50_Q6KIP9 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 81 3e-14
UniRef50_A4L2P0 Cluster: L-lactate dehydrogenase; n=4; Lactobaci... 81 4e-14
UniRef50_Q9P7P7 Cluster: Probable L-lactate dehydrogenase; n=2; ... 81 4e-14
UniRef50_P16115 Cluster: L-lactate dehydrogenase; n=4; Thermotog... 80 6e-14
UniRef50_Q3ZZJ7 Cluster: Malate dehydrogenase; n=5; cellular org... 79 9e-14
UniRef50_Q8IX04 Cluster: Ubiquitin-conjugating enzyme E2 variant... 79 1e-13
UniRef50_P62056 Cluster: L-lactate dehydrogenase; n=2; Bacteria|... 79 1e-13
UniRef50_A1HSK3 Cluster: Lactate/malate dehydrogenase; n=1; Ther... 76 8e-13
UniRef50_P59390 Cluster: L-lactate dehydrogenase 2; n=8; Lactoba... 76 8e-13
UniRef50_P47698 Cluster: L-lactate dehydrogenase; n=2; Mycoplasm... 75 1e-12
UniRef50_Q9CGG8 Cluster: L-lactate dehydrogenase 3; n=3; Lactoco... 75 2e-12
UniRef50_Q8RED8 Cluster: L-lactate dehydrogenase; n=3; Fusobacte... 74 4e-12
UniRef50_Q185V1 Cluster: L-lactate dehydrogenase; n=3; Clostridi... 72 1e-11
UniRef50_A6NLX8 Cluster: L-lactate dehydrogenase; n=4; Eutheria|... 70 7e-11
UniRef50_A1U9V0 Cluster: Lactate/malate dehydrogenase; n=6; Acti... 69 9e-11
UniRef50_Q64P62 Cluster: Malate dehydrogenase; n=28; Bacteroidet... 69 9e-11
UniRef50_A3JXA9 Cluster: L-lactate dehydrogenase; n=1; Sagittula... 69 1e-10
UniRef50_A7DRG3 Cluster: Lactate/malate dehydrogenase; n=1; Cand... 69 2e-10
UniRef50_A3ZZ88 Cluster: L-lactate/malate dehydrogenase; n=1; Bl... 67 4e-10
UniRef50_Q7UY63 Cluster: L-lactate/malate dehydrogenase; n=2; Pl... 67 5e-10
UniRef50_A2UB98 Cluster: Lactate/malate dehydrogenase precursor;... 66 8e-10
UniRef50_Q8VMZ6 Cluster: L-lactate dehydrogenase; n=1; Listeria ... 65 1e-09
UniRef50_A6Q7S2 Cluster: Malate dehydrogenase, NAD-dependent; n=... 65 2e-09
UniRef50_P50933 Cluster: L-lactate dehydrogenase; n=7; Bacteria|... 65 2e-09
UniRef50_Q9P4B6 Cluster: L-lactate dehydrogenase A; n=48; Rhizop... 64 3e-09
UniRef50_A4E9T4 Cluster: Putative uncharacterized protein; n=1; ... 63 6e-09
UniRef50_P59050 Cluster: L-lactate dehydrogenase 1; n=3; Bifidob... 63 6e-09
UniRef50_A4A2L6 Cluster: L-lactate dehydrogenase; n=4; Bacteria|... 62 1e-08
UniRef50_Q6ABQ3 Cluster: L-lactate dehydrogenase; n=1; Propionib... 62 2e-08
UniRef50_Q8TWG5 Cluster: Malate dehydrogenase; n=2; Euryarchaeot... 62 2e-08
UniRef50_Q59G78 Cluster: Lactate dehydrogenase B variant; n=1; H... 61 2e-08
UniRef50_A0RXX8 Cluster: Malate/L-lactate dehydrogenase; n=1; Ce... 61 2e-08
UniRef50_UPI000038D9FF Cluster: COG0039: Malate/lactate dehydrog... 61 3e-08
UniRef50_O08349 Cluster: Malate dehydrogenase; n=1; Archaeoglobu... 61 3e-08
UniRef50_A3EWH3 Cluster: Malate/lactate dehydrogenase; n=1; Lept... 60 4e-08
UniRef50_O67655 Cluster: Malate dehydrogenase 1; n=3; Bacteria|R... 60 6e-08
UniRef50_A0LRV1 Cluster: Lactate/malate dehydrogenase; n=3; Acti... 59 1e-07
UniRef50_Q9EVR0 Cluster: L-lactate dehydrogenase; n=1; Selenomon... 59 1e-07
UniRef50_Q98PG4 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 59 1e-07
UniRef50_O26290 Cluster: Malate dehydrogenase; n=2; Methanobacte... 58 2e-07
UniRef50_Q18WQ6 Cluster: Malate dehydrogenase, NAD-dependent; n=... 58 2e-07
UniRef50_Q4UJ29 Cluster: L-lactate dehydrogenase, putative; n=2;... 58 2e-07
UniRef50_Q27743 Cluster: L-lactate dehydrogenase; n=17; Apicompl... 58 2e-07
UniRef50_Q1FMY2 Cluster: L-lactate dehydrogenase; n=1; Clostridi... 58 3e-07
UniRef50_Q6JH30 Cluster: Lactate dehydrogenase; n=3; Plasmodium ... 58 3e-07
UniRef50_A2SSY4 Cluster: L-lactate dehydrogenase; n=3; Methanomi... 58 3e-07
UniRef50_Q6F0L9 Cluster: L-lactate dehydrogenase; n=6; Mollicute... 58 3e-07
UniRef50_Q3J7E7 Cluster: Malate dehydrogenase; n=5; Gammaproteob... 57 4e-07
UniRef50_Q87JV1 Cluster: Lactate dehydrogenase; n=4; Vibrio|Rep:... 57 5e-07
UniRef50_Q8YJE7 Cluster: Malate dehydrogenase; n=98; Bacteria|Re... 56 7e-07
UniRef50_P0C0J4 Cluster: L-lactate dehydrogenase; n=5; Mycoplasm... 56 9e-07
UniRef50_Q92BI0 Cluster: L-lactate dehydrogenase 2; n=18; Bacter... 56 9e-07
UniRef50_A7I5J9 Cluster: L-lactate dehydrogenase precursor; n=1;... 56 1e-06
UniRef50_Q92AZ3 Cluster: Lin1775 protein; n=13; Listeria|Rep: Li... 55 2e-06
UniRef50_Q0UX88 Cluster: L-lactate dehydrogenase; n=2; Phaeospha... 55 2e-06
UniRef50_Q03BE6 Cluster: L-lactate dehydrogenase; n=1; Lactobaci... 54 3e-06
UniRef50_Q07841 Cluster: Malate dehydrogenase; n=7; Halobacteria... 53 6e-06
UniRef50_Q7NHJ3 Cluster: Malate dehydrogenase; n=13; cellular or... 53 8e-06
UniRef50_A7DSJ4 Cluster: Lactate/malate dehydrogenase; n=1; Cand... 52 2e-05
UniRef50_Q82R06 Cluster: Putative lactate dehydrogenase; n=1; St... 51 3e-05
UniRef50_Q04GC4 Cluster: Enzyme with possible activities of L-2-... 50 8e-05
UniRef50_Q4A0K7 Cluster: Lactate dehydrogenase; n=1; Staphylococ... 49 1e-04
UniRef50_Q38YI2 Cluster: Putative malate dehydrogenase; n=1; Lac... 49 1e-04
UniRef50_Q03ZZ4 Cluster: Enzyme with possible activities of L-2-... 49 1e-04
UniRef50_Q7M9A7 Cluster: Malate dehydrogenase; n=4; Epsilonprote... 48 2e-04
UniRef50_UPI00015BB1FC Cluster: malate dehydrogenase (NAD); n=1;... 48 3e-04
UniRef50_A1C5Q5 Cluster: L-lactate dehydrogenase; n=4; Pezizomyc... 48 3e-04
UniRef50_Q8I8U4 Cluster: Lactate dehydrogenase; n=3; Eimeriorina... 47 4e-04
UniRef50_O67581 Cluster: Malate dehydrogenase 2; n=1; Aquifex ae... 47 4e-04
UniRef50_P14295 Cluster: L-2-hydroxyisocaproate dehydrogenase; n... 47 4e-04
UniRef50_Q7VFV4 Cluster: Malate dehydrogenase; n=1; Helicobacter... 47 6e-04
UniRef50_Q6A6E3 Cluster: L-lactate dehydrogenase; n=1; Propionib... 46 7e-04
UniRef50_Q2FPC3 Cluster: Lactate/malate dehydrogenase; n=2; Meth... 46 0.001
UniRef50_Q034P5 Cluster: Enzyme with possible activities of L-2-... 46 0.001
UniRef50_Q6LZI3 Cluster: Malate dehydrogenase; n=5; Methanococcu... 46 0.001
UniRef50_Q979N9 Cluster: Malate dehydrogenase; n=4; Thermoplasma... 45 0.002
UniRef50_UPI000023CE12 Cluster: hypothetical protein FG10444.1; ... 45 0.002
UniRef50_Q5FIY9 Cluster: L-LDH; n=6; Lactobacillus|Rep: L-LDH - ... 45 0.002
UniRef50_O52354 Cluster: L-lactate dehydrogenase; n=1; Mycoplasm... 44 0.003
UniRef50_A0RPE9 Cluster: Malate dehydrogenase; n=1; Campylobacte... 44 0.005
UniRef50_A7U552 Cluster: Mitochondrial malate-dehydrogenase; n=2... 44 0.005
UniRef50_P11386 Cluster: Malate dehydrogenase; n=6; Sulfolobacea... 44 0.005
UniRef50_A5Z9B1 Cluster: Putative uncharacterized protein; n=1; ... 43 0.007
UniRef50_Q5M0L6 Cluster: L-2-hydroxyisocaproate dehydrogenase; n... 43 0.009
UniRef50_Q0P989 Cluster: L-lactate dehydrogenase; n=10; Campylob... 42 0.012
UniRef50_Q88ZG9 Cluster: L-2-hydroxyisocaproate dehydrogenase; n... 42 0.021
UniRef50_A7I2F1 Cluster: Malate dehydrogenase; n=1; Campylobacte... 41 0.028
UniRef50_Q5CYZ2 Cluster: Lactate dehydrogenase, adjacent gene en... 41 0.028
UniRef50_Q8Y860 Cluster: Lmo1057 protein; n=11; Listeria|Rep: Lm... 41 0.036
UniRef50_Q7MTK2 Cluster: Malate dehydrogenase; n=4; Bacteroidale... 39 0.11
UniRef50_Q5LXE1 Cluster: Malate dehydrogenase; n=115; cellular o... 39 0.11
UniRef50_Q01VS4 Cluster: Methyltransferase type 11; n=1; Solibac... 39 0.15
UniRef50_A3CTN0 Cluster: Lactate/malate dehydrogenase; n=1; Meth... 38 0.26
UniRef50_Q8YXL9 Cluster: All1193 protein; n=2; Nostocaceae|Rep: ... 38 0.34
UniRef50_Q0PQR8 Cluster: Malate dehydrogenase NAD-dependent; n=1... 37 0.45
UniRef50_A2QJT7 Cluster: Catalytic activity: precursor; n=1; Asp... 37 0.45
UniRef50_A4BB89 Cluster: Lactate dehydrogenase; n=2; Gammaproteo... 37 0.59
UniRef50_A5IYS9 Cluster: L-lactate dehydrogenase; n=2; Mycoplasm... 36 0.78
UniRef50_Q8IE66 Cluster: Oxidoreductase, putative; n=6; Plasmodi... 36 0.78
UniRef50_Q5B0T8 Cluster: Putative uncharacterized protein; n=1; ... 36 0.78
UniRef50_Q6YPG1 Cluster: Putative uncharacterized protein OJA121... 36 1.0
UniRef50_A1CF32 Cluster: Forkhead domain protein; n=3; Trichocom... 35 2.4
UniRef50_Q182W1 Cluster: Putative exported protein precursor; n=... 34 3.2
UniRef50_A2SR33 Cluster: Lactate/malate dehydrogenase; n=1; Meth... 34 3.2
UniRef50_A2A0F6 Cluster: Transcriptional regulator, XRE family; ... 34 4.2
UniRef50_Q6VVP7 Cluster: Malate dehydrogenase; n=6; Plasmodium|R... 33 5.5
UniRef50_Q2LTZ4 Cluster: Hypothetical sex pilus assembly and syn... 33 7.3
UniRef50_Q097V0 Cluster: Putative uncharacterized protein; n=1; ... 33 7.3
UniRef50_A2SKC7 Cluster: Flagellin-related hook-associated prote... 33 9.7
>UniRef50_P07864 Cluster: L-lactate dehydrogenase C chain; n=371;
Eukaryota|Rep: L-lactate dehydrogenase C chain - Homo
sapiens (Human)
Length = 332
Score = 175 bits (427), Expect = 7e-43
Identities = 98/215 (45%), Positives = 130/215 (60%), Gaps = 10/215 (4%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
IIP ++ YSPD +++ SNPVDILTY+ WKISGLP RV +G G + AR
Sbjct: 120 IIPAIVHYSPDCKILVVSNPVDILTYIVWKISGLPVTRV------IGSGC----NLDSAR 169
Query: 182 YRY------HVLPXXXXXXXXXXXXSSMVC----INIAGVRLSDLNNQIGTDDDPENWKE 331
+RY V P S V +N+AGV L L+ ++GTD D E+WK
Sbjct: 170 FRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHWKN 229
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFL 511
+H+ V++SAYE+IKLKGYTSWAIGLS+ +V +IL N VH VST +KG +GI++E+FL
Sbjct: 230 IHKQVIQSAYEIIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFL 289
Query: 512 SLPCVLSHCGVSDVIRQPLTELEVAQLSGNLLKSW 616
S+PCVL GVSDV++ L E A + W
Sbjct: 290 SIPCVLGRNGVSDVVKINLNSEEEALFKKSAETLW 324
Score = 85.4 bits (202), Expect = 1e-15
Identities = 36/54 (66%), Positives = 45/54 (83%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+++G T IGSG NLDSARFRYL+ ++LG+ TSCHG+IIGEHGDSSVP+WS
Sbjct: 149 KISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWS 202
>UniRef50_UPI0000519EC7 Cluster: PREDICTED: similar to
Ecdysone-inducible gene L3 CG10160-PA; n=2;
Apocrita|Rep: PREDICTED: similar to Ecdysone-inducible
gene L3 CG10160-PA - Apis mellifera
Length = 409
Score = 143 bits (347), Expect = 3e-33
Identities = 87/214 (40%), Positives = 122/214 (57%), Gaps = 12/214 (5%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
IIP L+ YSP+ ++++ SNPVDIL+++TWKISGLP RV +G GT V AR
Sbjct: 196 IIPTLVGYSPNAVILVVSNPVDILSWLTWKISGLPASRV------IGTGT----HVDSAR 245
Query: 182 YRY------HVLPXXXXXXXXXXXXSSMV----CINIAGVRLSDLNNQIGTDDDPENWKE 331
+R+ + P S V +N+AGV+ D+ IG + D E W E
Sbjct: 246 FRFLIADRLGIAPSSVHATIIGEHGDSQVPLWSGVNVAGVQFRDILPNIGLETDEERWYE 305
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFL 511
L + VV+ V LKGYT+ IGL+ A IVRAIL N V VST ++G H + E+FL
Sbjct: 306 LSKEVVRLGPTVRCLKGYTNTTIGLATADIVRAILNNTQRVMPVSTLIQGHHEVCHEMFL 365
Query: 512 SLPCVLSHCGVSDVIRQPLTELE--VAQLSGNLL 607
SLPC + G++++IR +TE E + Q S N++
Sbjct: 366 SLPCSIGEQGITNIIRMRITEYEKKLFQTSANVV 399
Score = 76.6 bits (180), Expect = 6e-13
Identities = 33/57 (57%), Positives = 46/57 (80%)
Frame = +3
Query: 81 LRGRLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
L +++G ++ IG+GT++DSARFR+L++DRLGIA +S H IIGEHGDS VP+WS
Sbjct: 222 LTWKISGLPASRVIGTGTHVDSARFRFLIADRLGIAPSSVHATIIGEHGDSQVPLWS 278
>UniRef50_UPI0000DB7268 Cluster: PREDICTED: similar to L-lactate
dehydrogenase A chain (LDH-A) (LDH muscle subunit)
(LDH-M); n=2; Apis mellifera|Rep: PREDICTED: similar to
L-lactate dehydrogenase A chain (LDH-A) (LDH muscle
subunit) (LDH-M) - Apis mellifera
Length = 348
Score = 139 bits (336), Expect = 8e-32
Identities = 75/206 (36%), Positives = 116/206 (56%), Gaps = 13/206 (6%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
+IP++ KY+P++IL+I + PVDIL+Y K+SG P HRV +GLGT + R
Sbjct: 132 VIPKVCKYAPNSILLIVTAPVDILSYAAMKLSGFPPHRV------VGLGTF----LDSCR 181
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVC------------INIAGVRLSDLNNQIGTDDDPENW 325
++Y + +S++C + + G++L D+N IGT DPE+W
Sbjct: 182 FQYFI--AQKLGISASSVQASVICENGPTSVPIWSAVTVMGIKLKDINKDIGTKADPESW 239
Query: 326 KELHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKG-EHGIEDE 502
ELH V+ ++I KGY W +G+ A++V AI+ N VSTYLKG HG+E +
Sbjct: 240 GELHAKVIDCDNDLISRKGYRCWGMGICAAEVVDAIVRNTCICVTVSTYLKGCRHGLEKD 299
Query: 503 VFLSLPCVLSHCGVSDVIRQPLTELE 580
V++SLPC++ G+ ++R P T E
Sbjct: 300 VYMSLPCIVGRNGIETLLRHPYTPEE 325
Score = 55.2 bits (127), Expect = 2e-06
Identities = 25/57 (43%), Positives = 38/57 (66%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA*T 260
+L+G +G GT LDS RF+Y ++ +LGI+ +S +I E+G +SVP+WSA T
Sbjct: 161 KLSGFPPHRVVGLGTFLDSCRFQYFIAQKLGISASSVQASVICENGPTSVPIWSAVT 217
>UniRef50_Q6NPB9 Cluster: AT22132p; n=2; Drosophila
melanogaster|Rep: AT22132p - Drosophila melanogaster
(Fruit fly)
Length = 361
Score = 134 bits (323), Expect = 3e-30
Identities = 76/207 (36%), Positives = 115/207 (55%), Gaps = 6/207 (2%)
Frame = +2
Query: 5 IPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARY 184
+P+L++ SP+ +I SNP D++TY +I+ LPKHR L TV + R
Sbjct: 150 VPKLVELSPNATFIIISNPADVMTYAVQRITNLPKHRCFTTG--CHLDTVRFRNLIANRL 207
Query: 185 RYHVLPXXXXXXXXXXXXSSMV----CINIAGVRLSDLNNQIGTDDDPENWKELHENVVK 352
R + P +S V ++IAG+RL+D+ + DDPENW ++++ V
Sbjct: 208 R--LPPSQVHGYVIGEHGASAVPVWSSVSIAGIRLNDVVKNLACGDDPENWAKINKQVTT 265
Query: 353 SAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLS 532
V K KGYT+WAI L+ A IV+A+ + V T +KG GI+D V LSLPC+++
Sbjct: 266 GGLAVAKTKGYTNWAIALTCADIVQAMSGGKGKIACVGTDMKGLSGIQDNVVLSLPCLVT 325
Query: 533 HCGVSDVIRQPLTELEVAQL--SGNLL 607
G+S V PLT++E ++L S N+L
Sbjct: 326 AGGISHVFELPLTDVEQSKLLASANIL 352
Score = 58.0 bits (134), Expect = 2e-07
Identities = 23/43 (53%), Positives = 34/43 (79%)
Frame = +3
Query: 126 SGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
+G +LD+ RFR L+++RL + + HGY+IGEHG S+VPVWS+
Sbjct: 190 TGCHLDTVRFRNLIANRLRLPPSQVHGYVIGEHGASAVPVWSS 232
>UniRef50_Q7NG49 Cluster: L-lactate dehydrogenase; n=4;
Cyanobacteria|Rep: L-lactate dehydrogenase - Gloeobacter
violaceus
Length = 330
Score = 131 bits (316), Expect = 2e-29
Identities = 83/207 (40%), Positives = 118/207 (57%), Gaps = 10/207 (4%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
+I +++++ P+ IL++ SNPVD++TYV K++GLP RV +G GTV + AR
Sbjct: 119 LIGEIMEHCPNAILLVVSNPVDVMTYVAMKLAGLPPSRV------IGSGTV----LDTAR 168
Query: 182 YRY------HVLPXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKE 331
+RY V P S V + N+AG LS++ +GT DDP E
Sbjct: 169 FRYLLAERLRVDPRSLHAYIIGEHGDSEVPVWSRANVAGAFLSEIEPAVGTPDDPAKMFE 228
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFL 511
+ E+V +AYE+I+ KG TSWAIGL+ QIVRAI N N V VS + G HGIE EV L
Sbjct: 229 VFEHVKNAAYEIIERKGATSWAIGLATTQIVRAITRNQNRVLPVSVLMSGLHGIE-EVCL 287
Query: 512 SLPCVLSHCGVSDVIRQPLTELEVAQL 592
+ P VL+ G+ +++ L+ E QL
Sbjct: 288 AYPAVLNRQGIDRLVKFSLSPGEEEQL 314
>UniRef50_Q892U0 Cluster: L-lactate dehydrogenase; n=12;
Bacteria|Rep: L-lactate dehydrogenase - Clostridium
tetani
Length = 316
Score = 122 bits (293), Expect = 1e-26
Identities = 77/215 (35%), Positives = 122/215 (56%), Gaps = 12/215 (5%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+P+++KYSP +IL++ SNPVDILTYVT+K+SG P+ RV +G GTV + +R
Sbjct: 104 IVPEVVKYSPKSILLVVSNPVDILTYVTYKLSGFPQERV------IGSGTV----LDTSR 153
Query: 182 YRYHV----------LPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKE 331
+RY + + ++ NIAG+ + D I +
Sbjct: 154 FRYLLGEHFKIDVRNVHTYILGEHGDSEIAAWSLTNIAGISVEDYCKDICKGCEGNFKNR 213
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFL 511
+ E V +AYEV++ KGYTS+AI L++ +IV AI+ + +S+ VST L+GE+GI D +++
Sbjct: 214 IPEEVKNAAYEVLERKGYTSYAIALAVRRIVEAIIRDEDSILTVSTLLRGEYGIND-IYM 272
Query: 512 SLPCVLSHCGVSDVIRQPLTELEVAQL--SGNLLK 610
+P V+ G+ V+ L++ E QL S +LK
Sbjct: 273 GIPSVIGETGIKRVLEVKLSKDEEKQLKESAEVLK 307
Score = 61.3 bits (142), Expect = 2e-08
Identities = 27/54 (50%), Positives = 35/54 (64%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+L+G IGSGT LD++RFRYLL + I + H YI+GEHGDS + WS
Sbjct: 133 KLSGFPQERVIGSGTVLDTSRFRYLLGEHFKIDVRNVHTYILGEHGDSEIAAWS 186
>UniRef50_Q8XP62 Cluster: L-lactate dehydrogenase; n=11;
Clostridium|Rep: L-lactate dehydrogenase - Clostridium
perfringens
Length = 317
Score = 121 bits (291), Expect = 2e-26
Identities = 68/205 (33%), Positives = 112/205 (54%), Gaps = 2/205 (0%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+P+++KYSP++IL++ SNPVDILTY+T+K+SG PK RV L +
Sbjct: 105 IVPEVVKYSPNSILLVVSNPVDILTYITYKLSGFPKERVIGSGTVLDTSRLKYMLSEHFD 164
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAY 361
+ ++ NIAG + + + + D KEL E V +AY
Sbjct: 165 IDARNVHTYIIGEHGDSEITAWSLTNIAGANVEEYCKTVCANCDGSFKKELPEKVKNAAY 224
Query: 362 EVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCG 541
E+I KGYT++A+ L++ +IV AIL + N++ VS+ +G++GI D V+L++P ++ G
Sbjct: 225 EIINSKGYTNYAVALAVTRIVEAILRDENAILTVSSLFEGQYGI-DNVYLAMPTIVDRSG 283
Query: 542 VSDVIRQPLTELEVAQL--SGNLLK 610
++ P++ E L S +LK
Sbjct: 284 ARQILDVPISNEEKENLIKSAEILK 308
Score = 59.7 bits (138), Expect = 7e-08
Identities = 26/54 (48%), Positives = 35/54 (64%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+L+G IGSGT LD++R +Y+LS+ I + H YIIGEHGDS + WS
Sbjct: 134 KLSGFPKERVIGSGTVLDTSRLKYMLSEHFDIDARNVHTYIIGEHGDSEITAWS 187
>UniRef50_UPI0000DB7267 Cluster: PREDICTED: similar to
Ecdysone-inducible gene L3 CG10160-PA; n=1; Apis
mellifera|Rep: PREDICTED: similar to Ecdysone-inducible
gene L3 CG10160-PA - Apis mellifera
Length = 368
Score = 119 bits (286), Expect = 9e-26
Identities = 69/202 (34%), Positives = 109/202 (53%), Gaps = 7/202 (3%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQ-- 175
IIP + +++ ++L+I + P D+++Y+ WK+SG P +RV LG+GT+ A Q
Sbjct: 145 IIPAIARFAAKSVLLIVTRPADVMSYIAWKLSGFPSNRV------LGIGTLIDCARLQDF 198
Query: 176 ARYRYHVLPXXXXXXXXXXXXSSMV----CINIAGVRLSDLNNQIGTDDDPENWKELHEN 343
R +V V I++ G++L D+N++IG DDPE W E+ EN
Sbjct: 199 VSRRLNVARSSVSCMTIGSQGDMAVPLWSSISVGGMKLRDINSRIGEQDDPEKWYEIEEN 258
Query: 344 VVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTY-LKGEHGIEDEVFLSLP 520
V E+ + KG W + +S +IV AI+ N V ST+ L HG + +V++S+P
Sbjct: 259 VKSVGKELEEKKGSCCWGVAISTTEIVDAIVRNTKVVLPASTHILSCAHGTDKDVYMSVP 318
Query: 521 CVLSHCGVSDVIRQPLTELEVA 586
CV+ GV +RQ L+E E A
Sbjct: 319 CVIGREGVYCTVRQKLSEQEKA 340
Score = 46.0 bits (104), Expect = 0.001
Identities = 22/55 (40%), Positives = 33/55 (60%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
+L+G S +G GT +D AR + +S RL +A +S IG GD +VP+WS+
Sbjct: 174 KLSGFPSNRVLGIGTLIDCARLQDFVSRRLNVARSSVSCMTIGSQGDMAVPLWSS 228
>UniRef50_P22988 Cluster: L-lactate dehydrogenase A; n=19;
Magnoliophyta|Rep: L-lactate dehydrogenase A - Hordeum
vulgare (Barley)
Length = 356
Score = 118 bits (283), Expect = 2e-25
Identities = 73/207 (35%), Positives = 96/207 (46%), Gaps = 2/207 (0%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+P + ++SPD +L++ SNPVD+LTYV WK+SG P RV L
Sbjct: 142 IVPPVAEHSPDALLLVVSNPVDVLTYVAWKLSGFPASRVIGSGTNLDSSRFRFLIAEHLD 201
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAY 361
+ + I++ G+ D + + VV AY
Sbjct: 202 VNAQDVQAYMVGEHGDSSVAIWSSISVGGMPAFKSLRDSHRSFDEAALEGIRRAVVGGAY 261
Query: 362 EVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIED--EVFLSLPCVLSH 535
EVI LKGYTSWAIG S+A + ++L + VH VS G HGI D EVFLSLP L
Sbjct: 262 EVIGLKGYTSWAIGYSVASLAASLLRDQRRVHPVSVLASGFHGISDGHEVFLSLPARLGR 321
Query: 536 CGVSDVIRQPLTELEVAQLSGNLLKSW 616
G+ V LTE E AQL + W
Sbjct: 322 GGILGVAEMDLTEAEAAQLRRSAKTLW 348
Score = 66.9 bits (156), Expect = 5e-10
Identities = 27/55 (49%), Positives = 41/55 (74%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
+L+G ++ IGSGTNLDS+RFR+L+++ L + Y++GEHGDSSV +WS+
Sbjct: 171 KLSGFPASRVIGSGTNLDSSRFRFLIAEHLDVNAQDVQAYMVGEHGDSSVAIWSS 225
>UniRef50_P20619 Cluster: L-lactate dehydrogenase X; n=14;
Bacillales|Rep: L-lactate dehydrogenase X - Bacillus
psychrosaccharolyticus
Length = 319
Score = 111 bits (266), Expect = 2e-23
Identities = 77/216 (35%), Positives = 119/216 (55%), Gaps = 10/216 (4%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
++ Q++ D I +IA+NPVDILTY TWK SGLPK RV +G GT+ L + G+ R
Sbjct: 106 LVDQVMASGFDGIFLIATNPVDILTYATWKFSGLPKERV------IGSGTI-LDS-GRFR 157
Query: 182 YR----YHVLPXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKELH 337
+ + + P + + + +I GV + +L + + E+ +L
Sbjct: 158 FLLGEYFDIAPANVHAHIIGEHGDTELPVWSHADIGGVPVEELITR-NPEYKMEDLDQLF 216
Query: 338 ENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSL 517
NV +AY +IK KG T + I + LA+I +AIL N NSV VSTYL GE+G E +V++ +
Sbjct: 217 VNVRDAAYHIIKKKGATYYGIAMGLARITKAILNNENSVLTVSTYLDGEYG-EKDVYIGV 275
Query: 518 PCVLSHCGVSDVIRQPLTELEVAQL--SGNLLKSWL 619
P V++ G+ +++ L+E E Q S +LK L
Sbjct: 276 PAVVNRTGIREILELTLSETEQKQFTHSSTVLKEIL 311
Score = 63.7 bits (148), Expect = 5e-09
Identities = 28/54 (51%), Positives = 36/54 (66%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+ +G IGSGT LDS RFR+LL + IA + H +IIGEHGD+ +PVWS
Sbjct: 135 KFSGLPKERVIGSGTILDSGRFRFLLGEYFDIAPANVHAHIIGEHGDTELPVWS 188
>UniRef50_Q1IRL5 Cluster: L-lactate dehydrogenase; n=6;
Bacteria|Rep: L-lactate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 321
Score = 109 bits (263), Expect = 5e-23
Identities = 76/219 (34%), Positives = 122/219 (55%), Gaps = 12/219 (5%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+P+++K++PD +L+IA+NPVDI++Y ++KISGLP HRV LG GT+ + AR
Sbjct: 109 IVPEVVKHNPDGLLLIATNPVDIISYASYKISGLPAHRV------LGSGTI----LDTAR 158
Query: 182 YRY------HVLPXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKE 331
+RY V + V I NIAG+RL + D +
Sbjct: 159 FRYLLGQHFSVDARSVHGLILGEHGDTEVPIWSLANIAGIRLREYCRLHSLPYDEHVFDT 218
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFL 511
+ + +AY++I+ KG T +A+ + L QIV +I+ + +V ST ++G +GI D V+L
Sbjct: 219 IFTDTRDAAYKIIERKGATYYAVAVGLMQIVESIVRDQKTVLTTSTLVEGAYGIND-VYL 277
Query: 512 SLPCVLSHCGVSDVIRQPLTELEVAQL--SGNLLKSWLK 622
SLP ++ GV V+ L+E E+A+L S +LK ++
Sbjct: 278 SLPTIVGAKGVVQVLTPDLSEEELAKLQHSAEVLKGMIE 316
Score = 65.7 bits (153), Expect = 1e-09
Identities = 27/54 (50%), Positives = 37/54 (68%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+++G + +GSGT LD+ARFRYLL + S HG I+GEHGD+ VP+WS
Sbjct: 138 KISGLPAHRVLGSGTILDTARFRYLLGQHFSVDARSVHGLILGEHGDTEVPIWS 191
>UniRef50_Q81K80 Cluster: L-lactate dehydrogenase 2; n=12;
Firmicutes|Rep: L-lactate dehydrogenase 2 - Bacillus
anthracis
Length = 314
Score = 105 bits (252), Expect = 1e-21
Identities = 70/197 (35%), Positives = 109/197 (55%), Gaps = 9/197 (4%)
Frame = +2
Query: 32 DTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRY------H 193
D I +IA+NPVDILTYVTWK SGLPK RV +G GT + AR+RY
Sbjct: 115 DGIFLIATNPVDILTYVTWKESGLPKERV------IGSGTT----LDSARFRYMLGDYLD 164
Query: 194 VLPXXXXXXXXXXXXSSMVCI-NIAGVRLSDLNNQIGTDDD--PENWKELHENVVKSAYE 364
V P + + + + A + + L + ++ E+ ++ ENV +AY
Sbjct: 165 VDPRNVHAYIVGEHGDTELPVWSHATIGVQKLETILANNEQYKQEDLDKIFENVRDAAYH 224
Query: 365 VIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGV 544
+I+ KG T + IG+SL ++ +AIL N NSV VS YL+G++G E + ++ +P V++ GV
Sbjct: 225 IIERKGATYYGIGMSLLRVTKAILNNENSVLTVSAYLEGQYG-EKDAYVGVPAVINREGV 283
Query: 545 SDVIRQPLTELEVAQLS 595
+++ L E E A+ +
Sbjct: 284 REIVELELNEEEKAKFA 300
Score = 68.1 bits (159), Expect = 2e-10
Identities = 28/44 (63%), Positives = 34/44 (77%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IGSGT LDSARFRY+L D L + + H YI+GEHGD+ +PVWS
Sbjct: 144 IGSGTTLDSARFRYMLGDYLDVDPRNVHAYIVGEHGDTELPVWS 187
>UniRef50_UPI00015B6427 Cluster: PREDICTED: similar to lactate
dehydrogenase; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to lactate dehydrogenase - Nasonia vitripennis
Length = 352
Score = 102 bits (245), Expect = 8e-21
Identities = 69/204 (33%), Positives = 105/204 (51%), Gaps = 11/204 (5%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVP-------- 157
++P L KY+P+++L++ S PVD+L+++ K+SG P RV LGLGT+
Sbjct: 137 LVPSLTKYAPNSVLLVVSEPVDVLSHLAMKLSGFPSQRV------LGLGTLLDNCRLQHE 190
Query: 158 -LPAVGQARYRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKE- 331
+G + H + S+ ++ G++L D++ IG DPE +
Sbjct: 191 LAKELGVNQAAVHSMVIAESGPTSVPIWSAA---SVMGMKLKDIDKDIG---DPEGFAAA 244
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKG-EHGIEDEVF 508
LH VV E+I+ KG WA L +I+ AI+ N + VST++KG HG+E +VF
Sbjct: 245 LHAKVVNCNRELIRRKGQHCWAAALCTCEIIDAIVRNTCACLTVSTFVKGCRHGLEKDVF 304
Query: 509 LSLPCVLSHCGVSDVIRQPLTELE 580
SLPCVL GV +R T E
Sbjct: 305 ASLPCVLGRGGVLAYMRHLYTPEE 328
Score = 50.0 bits (114), Expect = 6e-05
Identities = 22/55 (40%), Positives = 34/55 (61%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
+L+G S +G GT LD+ R ++ L+ LG+ + H +I E G +SVP+WSA
Sbjct: 166 KLSGFPSQRVLGLGTLLDNCRLQHELAKELGVNQAAVHSMVIAESGPTSVPIWSA 220
>UniRef50_P19869 Cluster: L-lactate dehydrogenase 2; n=17;
Bacteria|Rep: L-lactate dehydrogenase 2 -
Bifidobacterium longum
Length = 320
Score = 101 bits (242), Expect = 2e-20
Identities = 61/198 (30%), Positives = 104/198 (52%), Gaps = 1/198 (0%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+P L+K +P+ I ++ +NPVDI T+V K++GLP++++ L + Q
Sbjct: 108 IMPNLVKVAPNAIYMLITNPVDIATHVAQKLTGLPENQIFGSGTNLDSARLRFLIAQQTG 167
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDD-DPENWKELHENVVKSA 358
+ I GV + D G D D + +E+H+ V +A
Sbjct: 168 VNVKNVHAYIAGEHGDSEVPLWESATIGGVPMCDWTPLPGHDPLDADKREEIHQEVKNAA 227
Query: 359 YEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHC 538
Y++I KG T++AIG+S I+ A+L + N + VS+ LK HGI D + +S+P +L+
Sbjct: 228 YKIINGKGATNYAIGMSGVDIIEAVLHDTNRILPVSSMLKDFHGISD-ICMSVPTLLNRQ 286
Query: 539 GVSDVIRQPLTELEVAQL 592
GV++ I P+++ E+A L
Sbjct: 287 GVNNTINTPVSDKELAAL 304
Score = 66.9 bits (156), Expect = 5e-10
Identities = 28/57 (49%), Positives = 37/57 (64%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA*T 260
+L G GSGTNLDSAR R+L++ + G+ + H YI GEHGDS VP+W + T
Sbjct: 137 KLTGLPENQIFGSGTNLDSARLRFLIAQQTGVNVKNVHAYIAGEHGDSEVPLWESAT 193
>UniRef50_Q97DC6 Cluster: L-lactate dehydrogenase 2; n=1;
Clostridium acetobutylicum|Rep: L-lactate dehydrogenase
2 - Clostridium acetobutylicum
Length = 320
Score = 101 bits (241), Expect = 2e-20
Identities = 72/216 (33%), Positives = 119/216 (55%), Gaps = 9/216 (4%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+ + KY+ D I+++ +NPVDI TY PK+++ +G GT+ L +
Sbjct: 108 IMKNICKYTKDAIIIVVTNPVDIATYYCQNNFDYPKNKI------IGTGTL-LDTARMRK 160
Query: 182 Y---RYHV----LPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHE 340
+Y+V + +S +NIAG+ + LN+ I D + E+ +
Sbjct: 161 IIGKKYNVDSKNVHGYVLGEHGGSSFTSWSDVNIAGIPFNQLND-IFKDHYKVDKDEVDK 219
Query: 341 NVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLP 520
V S EV+KLKGYTS I +S++++V+A+L N S+ VS+ L+GE+GI D V LS+P
Sbjct: 220 EVRDSGIEVLKLKGYTSAGIAMSVSRLVKAMLLNEQSILPVSSTLEGEYGIND-VALSIP 278
Query: 521 CVLSHCGVSDVIRQPLTELEVAQL--SGNLLKSWLK 622
C+++ G+ + PL++ EV +L S + LKS +K
Sbjct: 279 CIITSNGIEKKLEIPLSKDEVEKLNKSADNLKSIIK 314
Score = 50.8 bits (116), Expect = 3e-05
Identities = 20/44 (45%), Positives = 30/44 (68%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IG+GT LD+AR R ++ + + + + HGY++GEHG SS WS
Sbjct: 147 IGTGTLLDTARMRKIIGKKYNVDSKNVHGYVLGEHGGSSFTSWS 190
>UniRef50_O51114 Cluster: L-lactate dehydrogenase; n=4; Borrelia
burgdorferi group|Rep: L-lactate dehydrogenase -
Borrelia burgdorferi (Lyme disease spirochete)
Length = 316
Score = 98.3 bits (234), Expect = 2e-19
Identities = 69/217 (31%), Positives = 111/217 (51%), Gaps = 11/217 (5%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
II ++ D I V+ASNPVDI+TYVT K S P H+V +G GT+ + +R
Sbjct: 105 IITNVVSSGFDGIFVVASNPVDIMTYVTMKYSKFPIHKV------IGTGTI----LDTSR 154
Query: 182 YRYHV-------LPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPE-NWKELH 337
RY + SS + + + L+ + E E+H
Sbjct: 155 LRYFLSDHFNVNTQNIHSYIMGEHGDSSFATWDETKIAMKPLSEYLAEGKITELELDEIH 214
Query: 338 ENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEH-GIEDEVFLS 514
+ VV +AYEVIKLKG T +AIGL + IV AI+ + N + +S+Y+ G++ G+ ++++
Sbjct: 215 KKVVNAAYEVIKLKGATYYAIGLGIKNIVNAIIGDQNVILPISSYINGQYGGLIKDIYIG 274
Query: 515 LPCVLSHCGVSDVIRQPLT--ELEVAQLSGNLLKSWL 619
P ++ GV +V+ ++ EL+ S N LKS++
Sbjct: 275 APAIVCKEGVKEVLNFKISPKELDKFNSSANQLKSYI 311
Score = 58.4 bits (135), Expect = 2e-07
Identities = 24/43 (55%), Positives = 30/43 (69%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 248
IG+GT LD++R RY LSD + T + H YI+GEHGDSS W
Sbjct: 144 IGTGTILDTSRLRYFLSDHFNVNTQNIHSYIMGEHGDSSFATW 186
>UniRef50_Q4SRH5 Cluster: L-lactate dehydrogenase; n=4;
Euteleostomi|Rep: L-lactate dehydrogenase - Tetraodon
nigroviridis (Green puffer)
Length = 360
Score = 97.5 bits (232), Expect = 3e-19
Identities = 54/120 (45%), Positives = 66/120 (55%), Gaps = 2/120 (1%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
IIPQ+IKYSP+ L++ SNPVD+LTYVTWK+SGLPKHRV + L + + R
Sbjct: 121 IIPQIIKYSPNCTLIVVSNPVDVLTYVTWKLSGLPKHRV--IGSGTNLDSARFRYLMAER 178
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVC--INIAGVRLSDLNNQIGTDDDPENWKELHENVVKS 355
H S V N+AGV L LN IGTDDD E W+ H+ VV S
Sbjct: 179 LGIHASSFNGWVLGEHGDTSVPVWSGANVAGVNLQKLNPDIGTDDDKEEWRATHKAVVDS 238
Score = 79.0 bits (186), Expect = 1e-13
Identities = 34/54 (62%), Positives = 45/54 (83%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+L+G IGSGTNLDSARFRYL+++RLGI +S +G+++GEHGD+SVPVWS
Sbjct: 150 KLSGLPKHRVIGSGTNLDSARFRYLMAERLGIHASSFNGWVLGEHGDTSVPVWS 203
Score = 44.4 bits (100), Expect = 0.003
Identities = 23/61 (37%), Positives = 30/61 (49%)
Frame = +1
Query: 349 EKCLRSHQTEGIHFLGYRTVAGSDREGYTHER*QRSCGLYLSQGRARHRRRSIFVAAVRV 528
+ CL Q EG+H LG+R G + E GL+ Q RHRR + VAA+R
Sbjct: 253 QDCLPGDQAEGLHQLGHRPECGRPHREHRQEHEPSPPGLHHGQRHVRHRRGGLPVAALRA 312
Query: 529 E 531
E
Sbjct: 313 E 313
>UniRef50_Q838C9 Cluster: L-lactate dehydrogenase 2; n=9;
Bacilli|Rep: L-lactate dehydrogenase 2 - Enterococcus
faecalis (Streptococcus faecalis)
Length = 317
Score = 97.1 bits (231), Expect = 4e-19
Identities = 75/214 (35%), Positives = 109/214 (50%), Gaps = 11/214 (5%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTV--PLPAVGQ 175
I+ ++K D ILVIASNPVD+LTYV W+ SGLP RV +G GT +
Sbjct: 105 IVNNIMKSGFDGILVIASNPVDVLTYVAWQASGLPVSRV------IGTGTTLDTTRFRKE 158
Query: 176 ARYRYHVLPXXXXXXXXXXXXSSMVCI---NIAGVR----LSDLNNQIGTDDDPENWKEL 334
R + P S V + + G + + D ++ +DD P +
Sbjct: 159 LSQRLAIDPRNVHGYIIGEHGDSEVAVWSHTMIGTKPILEIVDTTERLTSDDLPI----I 214
Query: 335 HENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLS 514
+ V +AYE+I K T + IG+S A+IV+AIL N ++ VS YL G++G +D VF
Sbjct: 215 SDKVKNTAYEIIDRKQATYYGIGMSTARIVKAILNNEQAILPVSAYLDGQYGQQD-VFTG 273
Query: 515 LPCVLSHCGVSDVIRQPL--TELEVAQLSGNLLK 610
+P V+ + GV+D+I L E E+ Q S LK
Sbjct: 274 IPAVVGNQGVTDIIELNLNAAEKELFQKSVTQLK 307
Score = 63.3 bits (147), Expect = 6e-09
Identities = 29/44 (65%), Positives = 32/44 (72%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IG+GT LD+ RFR LS RL I + HGYIIGEHGDS V VWS
Sbjct: 144 IGTGTTLDTTRFRKELSQRLAIDPRNVHGYIIGEHGDSEVAVWS 187
>UniRef50_Q2S4R2 Cluster: L-lactate dehydrogenase; n=1; Salinibacter
ruber DSM 13855|Rep: L-lactate dehydrogenase -
Salinibacter ruber (strain DSM 13855)
Length = 316
Score = 95.1 bits (226), Expect = 2e-18
Identities = 71/199 (35%), Positives = 106/199 (53%), Gaps = 6/199 (3%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
II QL K++P+ ILV+A+NPVD+LTY+ ++S P R+ LG GT+ A +A
Sbjct: 104 IIIQLDKHAPNAILVVATNPVDVLTYICQELSSRPNRRI------LGTGTLLDTARFRAL 157
Query: 182 Y--RYHVLPXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKELHEN 343
Y V P S V I I G ++ +G + + E + + E
Sbjct: 158 LGRHYGVDPRSVHAYILGEHGDSEVPIWSNATIGGQKIRG-ETVLGKEWEEEAMQSIFEQ 216
Query: 344 VVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPC 523
+AYE+I KG+T AIGL +A+IVRA+L + +V VST G +GI D+V LS+PC
Sbjct: 217 ARDAAYEIIDRKGHTDTAIGLVIARIVRAVLEDQQNVLPVSTRPDGAYGI-DDVCLSVPC 275
Query: 524 VLSHCGVSDVIRQPLTELE 580
V+ G+ + L++ E
Sbjct: 276 VVGLEGMEKRVDPGLSDEE 294
Score = 62.1 bits (144), Expect = 1e-08
Identities = 26/44 (59%), Positives = 32/44 (72%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+G+GT LD+ARFR LL G+ S H YI+GEHGDS VP+WS
Sbjct: 143 LGTGTLLDTARFRALLGRHYGVDPRSVHAYILGEHGDSEVPIWS 186
>UniRef50_A6M0Q2 Cluster: L-lactate dehydrogenase; n=1; Clostridium
beijerinckii NCIMB 8052|Rep: L-lactate dehydrogenase -
Clostridium beijerinckii NCIMB 8052
Length = 316
Score = 94.7 bits (225), Expect = 2e-18
Identities = 64/211 (30%), Positives = 105/211 (49%), Gaps = 10/211 (4%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+P ++K I+V+ +NPVD+++Y K+SGLP +V +G GT A+ AR
Sbjct: 105 IVPNIMKSGFSGIIVVITNPVDVMSYYVHKLSGLPASKV------IGTGT----ALDSAR 154
Query: 182 YRYHVL------PXXXXXXXXXXXXSSMVC----INIAGVRLSDLNNQIGTDDDPENWKE 331
+YH+ P S + I + G + D+ N N
Sbjct: 155 LKYHLADVMSVDPQSVHALCMGEHGDSQIIPWSQITVGGKKFLDIINDNKMRLKGFNLNS 214
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFL 511
+ E++ K AY ++ KG T++ I + QIV+AIL + N V VS L GE+G E + +
Sbjct: 215 VTEDIKKIAYRIVNAKGATTFGIAATTVQIVKAILRDENKVIPVSAMLNGEYG-ESDTYA 273
Query: 512 SLPCVLSHCGVSDVIRQPLTELEVAQLSGNL 604
+P VL++ GV +++ L E E A+L ++
Sbjct: 274 GVPAVLNNQGVKELVEYHLVESEKAELKESI 304
Score = 54.4 bits (125), Expect = 3e-06
Identities = 24/54 (44%), Positives = 35/54 (64%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+L+G ++ IG+GT LDSAR +Y L+D + + S H +GEHGDS + WS
Sbjct: 134 KLSGLPASKVIGTGTALDSARLKYHLADVMSVDPQSVHALCMGEHGDSQIIPWS 187
>UniRef50_A5KJY5 Cluster: Putative uncharacterized protein; n=2;
Ruminococcus|Rep: Putative uncharacterized protein -
Ruminococcus torques ATCC 27756
Length = 316
Score = 94.3 bits (224), Expect = 3e-18
Identities = 65/207 (31%), Positives = 110/207 (53%), Gaps = 10/207 (4%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
II ++ + + + IL+I SNPVDILT V + SG PK RV +G GTV + AR
Sbjct: 103 IIKEIKRVNCEGILLIVSNPVDILTEVALRESGFPKERV------IGSGTV----LDTAR 152
Query: 182 YRYHV----------LPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKE 331
+Y + + ++ C NI G++L D G + ++ +E
Sbjct: 153 LKYIISEKLDVDSRNVHAFIVGEHGDSELAAWSCANIYGIKLQDFAKMRGYEHFAQDMEE 212
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFL 511
+++ V SAYE+I+ KG T + IG++ +IV AI+ N+++V +S L G++G+E + L
Sbjct: 213 VYKGVRDSAYEIIERKGATYYGIGMAAEKIVEAIVRNSHTVAPISVSLDGKYGLEG-LCL 271
Query: 512 SLPCVLSHCGVSDVIRQPLTELEVAQL 592
S+P ++ G V+ +E E+ +L
Sbjct: 272 SIPTIVGRGGAEQVLEIDFSEEEMKKL 298
Score = 58.8 bits (136), Expect = 1e-07
Identities = 24/54 (44%), Positives = 37/54 (68%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
R +G IGSGT LD+AR +Y++S++L + + + H +I+GEHGDS + WS
Sbjct: 132 RESGFPKERVIGSGTVLDTARLKYIISEKLDVDSRNVHAFIVGEHGDSELAAWS 185
>UniRef50_Q4JY42 Cluster: L-lactate dehydrogenase; n=1;
Corynebacterium jeikeium K411|Rep: L-lactate
dehydrogenase - Corynebacterium jeikeium (strain K411)
Length = 326
Score = 93.1 bits (221), Expect = 6e-18
Identities = 67/215 (31%), Positives = 110/215 (51%), Gaps = 12/215 (5%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+ ++ + + I ++ASNPVDIL+Y TWK SG+ RV +G GT+ + AR
Sbjct: 115 IVGDVMSHGFNGIFLVASNPVDILSYATWKFSGMDSSRV------IGSGTI----LDTAR 164
Query: 182 YRY------HVLPXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKE 331
+RY + P + + + ++AG + IG D E+ E
Sbjct: 165 FRYALGRYFDLAPTSVHAYVIGEHGDTELPVLSAGSVAGTSIHHRLEMIGESAD-EDVDE 223
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFL 511
+ +AYE+I+ KG TS+ IG+ LA+I +A+ +N + V +ST L+GE+G ED +++
Sbjct: 224 IFVKTRDAAYEIIQAKGSTSFGIGMGLARITQAVFSNQDVVLPISTLLQGEYGFED-IYI 282
Query: 512 SLPCVLSHCGVSDVIRQPL--TELEVAQLSGNLLK 610
P V++ GV + L E E S N+L+
Sbjct: 283 GTPAVINRQGVRHAVELQLDSEEKERFDHSANVLR 317
Score = 64.5 bits (150), Expect = 3e-09
Identities = 30/55 (54%), Positives = 38/55 (69%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
+ +G S+ IGSGT LD+ARFRY L +A TS H Y+IGEHGD+ +PV SA
Sbjct: 144 KFSGMDSSRVIGSGTILDTARFRYALGRYFDLAPTSVHAYVIGEHGDTELPVLSA 198
>UniRef50_P62051 Cluster: L-lactate dehydrogenase; n=2;
Desulfovibrio vulgaris subsp. vulgaris|Rep: L-lactate
dehydrogenase - Desulfovibrio vulgaris (strain
Hildenborough / ATCC 29579 / NCIMB8303)
Length = 309
Score = 92.7 bits (220), Expect = 9e-18
Identities = 67/210 (31%), Positives = 113/210 (53%), Gaps = 10/210 (4%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+ +++Y+ D + ++A+NPVD+LT+V ++G+ RV +G GTV + AR
Sbjct: 100 ILTAVMQYADDPLYIMATNPVDVLTHVARTVTGVAPGRV------IGSGTV----LDSAR 149
Query: 182 YRYHVLPXXXXXXXXXXXX------SSMVCI----NIAGVRLSDLNNQIGTDDDPENWKE 331
+R HV S V + N++G+ ++++ + G D ++
Sbjct: 150 FRGHVAEILGVDVRGVHAHIVGEHGDSEVALWSRANVSGIPVAEMCARRGIAYDAAFREK 209
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFL 511
+V +AYE+I KG T + IG+SL +IV AIL + +SV VS + G +G+ D V L
Sbjct: 210 ALGHVRHAAYEIIGRKGATGYGIGMSLCRIVEAILHDEHSVLTVSCPVAGHYGLGD-VSL 268
Query: 512 SLPCVLSHCGVSDVIRQPLTELEVAQLSGN 601
SLPCV+ G+ +V+ P+ E E A L+ +
Sbjct: 269 SLPCVIGSDGIEEVLDAPIAEDEQAALAAS 298
Score = 56.8 bits (131), Expect = 5e-07
Identities = 25/44 (56%), Positives = 32/44 (72%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IGSGT LDSARFR +++ LG+ H +I+GEHGDS V +WS
Sbjct: 139 IGSGTVLDSARFRGHVAEILGVDVRGVHAHIVGEHGDSEVALWS 182
>UniRef50_Q1FID3 Cluster: L-lactate dehydrogenase precursor; n=1;
Clostridium phytofermentans ISDg|Rep: L-lactate
dehydrogenase precursor - Clostridium phytofermentans
ISDg
Length = 325
Score = 90.2 bits (214), Expect = 5e-17
Identities = 62/213 (29%), Positives = 112/213 (52%), Gaps = 12/213 (5%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+ ++K + I ++ +NPVD + +++SGLPK +V LG GT A+ AR
Sbjct: 107 IVEPVMKSGFNGIFLVVTNPVDSIAQYVYQLSGLPKQQV------LGTGT----AIDSAR 156
Query: 182 YRY------HVLPXXXXXXXXXXXXSSMVC----INIAGVRLSDL--NNQIGTDDDPENW 325
++ HV P S +C + + G + D+ +N+ +D D +
Sbjct: 157 LKHFIGDILHVDPRSIQAYTMGEHGDSQMCPWSLVTVGGKNIMDIVRDNKEYSDID---F 213
Query: 326 KELHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEV 505
E+ V + ++++ +KG T + I + I++AIL + NS+ VST L+GE+G E +V
Sbjct: 214 NEILYKVTRVGFDILSVKGTTCYGIASAAVGIIKAILYDENSILPVSTLLEGEYG-EFDV 272
Query: 506 FLSLPCVLSHCGVSDVIRQPLTELEVAQLSGNL 604
+ +PC+L+ GV DV+ +TE+E+ Q ++
Sbjct: 273 YAGVPCILNRFGVKDVVEVNMTEVELNQFRASV 305
Score = 48.4 bits (110), Expect = 2e-04
Identities = 21/54 (38%), Positives = 32/54 (59%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+L+G +G+GT +DSAR ++ + D L + S Y +GEHGDS + WS
Sbjct: 136 QLSGLPKQQVLGTGTAIDSARLKHFIGDILHVDPRSIQAYTMGEHGDSQMCPWS 189
>UniRef50_P0A3M9 Cluster: L-lactate dehydrogenase; n=140;
Bacteria|Rep: L-lactate dehydrogenase - Streptococcus
pneumoniae
Length = 328
Score = 90.2 bits (214), Expect = 5e-17
Identities = 66/210 (31%), Positives = 105/210 (50%), Gaps = 10/210 (4%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+ Q+++ I ++A+NPVD+LTY TWK SG PK RV +G GT ++ AR
Sbjct: 108 IVTQVVESGFKGIFLVAANPVDVLTYSTWKFSGFPKERV------IGSGT----SLDSAR 157
Query: 182 YRY------HVLPXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKE 331
+R V S + NIAGV L + + E E
Sbjct: 158 FRQALAEKLDVDARSVHAYIMGEHGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAE-LIE 216
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFL 511
L E V +AY +I KG T + I ++LA+I +AIL + N+V +S + +G++G+E+ VF+
Sbjct: 217 LFEGVRDAAYTIINKKGATYYGIAVALARITKAILDDENAVLPLSVFQEGQYGVEN-VFI 275
Query: 512 SLPCVLSHCGVSDVIRQPLTELEVAQLSGN 601
P V+ G+ + PL + E ++ +
Sbjct: 276 GQPAVVGAHGIVRPVNIPLNDAETQKMQAS 305
Score = 62.9 bits (146), Expect = 8e-09
Identities = 28/54 (51%), Positives = 36/54 (66%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+ +G IGSGT+LDSARFR L+++L + S H YI+GEHGDS VWS
Sbjct: 137 KFSGFPKERVIGSGTSLDSARFRQALAEKLDVDARSVHAYIMGEHGDSEFAVWS 190
>UniRef50_A3DCA4 Cluster: L-lactate dehydrogenase precursor; n=2;
Clostridium|Rep: L-lactate dehydrogenase precursor -
Clostridium thermocellum (strain ATCC 27405 / DSM 1237)
Length = 318
Score = 84.2 bits (199), Expect = 3e-15
Identities = 67/224 (29%), Positives = 112/224 (50%), Gaps = 12/224 (5%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
+ ++KY ++++ SNPVDI+TY+ K SGLP +V +G GTV + R
Sbjct: 106 VTQNIMKYYNHGVILVVSNPVDIITYMIQKWSGLPVGKV------IGSGTV----LDSIR 155
Query: 182 YRYHV-------LPXXXXXXXXXXXXSSMV---CINIAGVRLSDLNNQIGTDDDPENWKE 331
+RY + + S + C +IAG +++ + + E+ K+
Sbjct: 156 FRYLLSEKLGVDVKNVHGYIIGEHGDSQLPLWSCTHIAGKNINEYIDDPKCNFTEEDKKK 215
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFL 511
+ E+V + +IK KG T + I +S+ IV +L N N++ V T + G +GIED V +
Sbjct: 216 IAEDVKTAGATIIKNKGATYYGIAVSINTIVETLLKNQNTIRTVGTVINGMYGIED-VAI 274
Query: 512 SLPCVLSHCGVSDVIRQPLT--ELEVAQLSGNLLKSWLKLRDNL 637
SLP +++ GV +V++ LT E E + S +K L NL
Sbjct: 275 SLPSIVNSEGVQEVLQFNLTPEEEEALRFSAEQVKKVLNEVKNL 318
Score = 73.3 bits (172), Expect = 6e-12
Identities = 31/44 (70%), Positives = 37/44 (84%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IGSGT LDS RFRYLLS++LG+ + HGYIIGEHGDS +P+WS
Sbjct: 145 IGSGTVLDSIRFRYLLSEKLGVDVKNVHGYIIGEHGDSQLPLWS 188
>UniRef50_Q6A9C3 Cluster: L-lactate dehydrogenase; n=2;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 319
Score = 84.2 bits (199), Expect = 3e-15
Identities = 58/203 (28%), Positives = 99/203 (48%), Gaps = 3/203 (1%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
++PQL++ SP+ + V+ +NP D+LT V + +GLP +RV L + A
Sbjct: 109 LMPQLVEQSPNALFVLVTNPCDVLTVVAQEATGLPANRVFSTGTMLDTSRLRWLIRQWAN 168
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDL---NNQIGTDDDPENWKELHENVVK 352
+ NI+GV + D N++ T+D +L
Sbjct: 169 VEQRHVHATIVGEHGDSEFPLWSTANISGVPIRDWAVDGNRVFTEDV---LADLAHEAAY 225
Query: 353 SAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLS 532
+AY++I+ KG T++AIGL+ A++ A+L SV +S+ + HGI V LS+PC++S
Sbjct: 226 AAYKIIEGKGATNYAIGLTGARLAEALLRPGRSVLPLSSVMTDMHGISG-VALSMPCIVS 284
Query: 533 HCGVSDVIRQPLTELEVAQLSGN 601
G+ V+ + E+A L +
Sbjct: 285 RDGIEGVVPVAMDTEEIASLKAS 307
Score = 46.0 bits (104), Expect = 0.001
Identities = 19/51 (37%), Positives = 28/51 (54%)
Frame = +3
Query: 99 GCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
G + +GT LD++R R+L+ + H I+GEHGDS P+WS
Sbjct: 141 GLPANRVFSTGTMLDTSRLRWLIRQWANVEQRHVHATIVGEHGDSEFPLWS 191
>UniRef50_Q8ELF0 Cluster: L-lactate dehydrogenase; n=5;
Bacillaceae|Rep: L-lactate dehydrogenase -
Oceanobacillus iheyensis
Length = 321
Score = 84.2 bits (199), Expect = 3e-15
Identities = 60/205 (29%), Positives = 104/205 (50%), Gaps = 7/205 (3%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+ ++ + I +IA+NPVDILT SGLP HRV +G GT A + R
Sbjct: 108 IVTDVMNSGFNGIFLIATNPVDILTQAVISFSGLPPHRV------IGSGTTLDTA--RLR 159
Query: 182 YR----YHVLPXXXXXXXXXXXXSSMVCI-NIAGVRLSDLNNQIGTDDD--PENWKELHE 340
Y +H+ P + + + + A + L + + E+ ++
Sbjct: 160 YELGEYFHLSPKNIHAYIIGEHGDTELPLWSTATIGTVPLLTYLNRSESYTTEDLDDIFT 219
Query: 341 NVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLP 520
NV +AY +I+ KG T + I +SL ++ AIL + +S+ S++L+GE+G+ D V + +P
Sbjct: 220 NVRDAAYRIIQKKGATYYGIAMSLVRVTEAILKDEHSILTTSSFLQGEYGV-DNVCIGVP 278
Query: 521 CVLSHCGVSDVIRQPLTELEVAQLS 595
+++ GVS++I P+ E E Q +
Sbjct: 279 TIINRNGVSEIIEVPMNEDEQKQFN 303
Score = 59.3 bits (137), Expect = 1e-07
Identities = 25/47 (53%), Positives = 33/47 (70%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA*T 260
IGSGT LD+AR RY L + ++ + H YIIGEHGD+ +P+WS T
Sbjct: 147 IGSGTTLDTARLRYELGEYFHLSPKNIHAYIIGEHGDTELPLWSTAT 193
>UniRef50_Q81XJ7 Cluster: L-lactate dehydrogenase 3; n=13;
Firmicutes|Rep: L-lactate dehydrogenase 3 - Bacillus
anthracis
Length = 316
Score = 84.2 bits (199), Expect = 3e-15
Identities = 62/209 (29%), Positives = 105/209 (50%), Gaps = 12/209 (5%)
Frame = +2
Query: 32 DTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYR------YH 193
D I ++ASNPVDI+TY WK+SGLP++RV +G GT ++ +R R H
Sbjct: 115 DGIFLLASNPVDIITYQVWKLSGLPRNRV------IGTGT----SLDSSRLRTILSEMLH 164
Query: 194 VLPXXXXXXXXXXXXSSMVC----INIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAY 361
V P S + + + G + + + + E+ E K+ +
Sbjct: 165 VDPRSIHGYSLGEHGDSQMVAWSHVTVGGKPILQILEEQKERFGEIDLDEIVEKTAKAGW 224
Query: 362 EVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCG 541
E+ K KG T + IG SLA I +I + + V AVS L GE+G E ++ +P +++ G
Sbjct: 225 EIYKRKGTTYYGIGNSLAYIASSIFNDDHRVIAVSAILDGEYG-EYDICTGVPAIITRDG 283
Query: 542 VSDVIRQPLTELEVAQL--SGNLLKSWLK 622
+ +++ LTE E ++ S ++L+ ++K
Sbjct: 284 IREIVELNLTEDEESRFAKSNDILRDYMK 312
Score = 59.3 bits (137), Expect = 1e-07
Identities = 26/54 (48%), Positives = 36/54 (66%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+L+G IG+GT+LDS+R R +LS+ L + S HGY +GEHGDS + WS
Sbjct: 134 KLSGLPRNRVIGTGTSLDSSRLRTILSEMLHVDPRSIHGYSLGEHGDSQMVAWS 187
>UniRef50_Q3U1V6 Cluster: Ubiquitin-conjugating enzyme E2 variant 3;
n=23; Tetrapoda|Rep: Ubiquitin-conjugating enzyme E2
variant 3 - Mus musculus (Mouse)
Length = 471
Score = 83.0 bits (196), Expect = 7e-15
Identities = 36/68 (52%), Positives = 52/68 (76%)
Frame = +2
Query: 356 AYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSH 535
A E++K+KG SW++GLS+A +V I+ N VH+VST KG +G+++EVFLSLPC+L
Sbjct: 376 AMELLKVKGQRSWSVGLSVADLVDTIINNKRKVHSVSTLAKGYYGLDNEVFLSLPCILGT 435
Query: 536 CGVSDVIR 559
GVS+VI+
Sbjct: 436 GGVSEVIK 443
Score = 47.2 bits (107), Expect = 4e-04
Identities = 19/39 (48%), Positives = 28/39 (71%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRV 118
++P L YS +L++AS PV+I++YVTWK+S P RV
Sbjct: 276 LVPALGHYSQHAVLLVASQPVEIMSYVTWKLSTFPATRV 314
Score = 42.7 bits (96), Expect = 0.009
Identities = 17/48 (35%), Positives = 30/48 (62%)
Frame = +3
Query: 108 STAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+T +G G NLDS R +Y+++ L + T+ +++GE G++ V WS
Sbjct: 311 ATRVVGIGCNLDSQRLQYIITSVLKVQTSGKEVWVVGEQGENKVCSWS 358
>UniRef50_Q8ZVB2 Cluster: Malate dehydrogenase; n=14;
Thermoprotei|Rep: Malate dehydrogenase - Pyrobaculum
aerophilum
Length = 309
Score = 83.0 bits (196), Expect = 7e-15
Identities = 59/195 (30%), Positives = 94/195 (48%), Gaps = 5/195 (2%)
Frame = +2
Query: 11 QLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRY 190
++ KY+PD+I+++ +NP+D +TYV WK +G P+ RV L G + A +
Sbjct: 103 EIKKYAPDSIVILTTNPLDAMTYVMWKATGFPRERVIGFSGVLDAGRLAF----YAAKKL 158
Query: 191 HVLPXXXXXXXXXXXXSSMVCIN----IAGVRLSDLNNQIGTDDDPENWKELHENVVKSA 358
+ P SM + + GV LS L + E KE+ E VK+
Sbjct: 159 GISPASILPIVLGQHGESMFPVPSKSYVHGVPLSKLLTE-------EQLKEVVEETVKAG 211
Query: 359 YEVIKLKGYTS-WAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSH 535
+ +L+G++S W G LA + A+ +A S L+GE+G+ D V + +P +L
Sbjct: 212 ARITELRGFSSNWGPGAGLAIMAEAVKRDAKRALIASVVLQGEYGVRD-VPVEVPIILGR 270
Query: 536 CGVSDVIRQPLTELE 580
GV V+ LTE E
Sbjct: 271 SGVVKVLEVELTEEE 285
Score = 33.9 bits (74), Expect = 4.2
Identities = 15/42 (35%), Positives = 24/42 (57%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 245
IG LD+ R + + +LGI+ S ++G+HG+S PV
Sbjct: 139 IGFSGVLDAGRLAFYAAKKLGISPASILPIVLGQHGESMFPV 180
>UniRef50_A4QXM2 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 323
Score = 82.6 bits (195), Expect = 9e-15
Identities = 60/210 (28%), Positives = 103/210 (49%), Gaps = 7/210 (3%)
Frame = +2
Query: 2 IIPQLIKY-SPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPA--VG 172
I+P+++++ SPD +L++++NPVD++TY K SG P H V +G GT A G
Sbjct: 111 IVPKVVQHASPDALLLVSANPVDVMTYAAVKFSGFPAHSV------IGSGTSLDSARFAG 164
Query: 173 QARYRYHVLPXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKELHE 340
+ ++ P S + + ++G+R+ D Q GT D E K+
Sbjct: 165 ELGKHLNIDPRSLHAVVIGEHGESELPVWSLATVSGMRVEDYCRQTGTPWDEETKKQCFA 224
Query: 341 NVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLP 520
NV +A +I+ KG T + I +L +IV + + N++ VS G + D+V LS+P
Sbjct: 225 NVKDAAAAIIEKKGVTGYGIASALLRIVECVRRDENTLMPVSCV--GSYAGVDDVALSVP 282
Query: 521 CVLSHCGVSDVIRQPLTELEVAQLSGNLLK 610
L+ G + + L++ E L + K
Sbjct: 283 RKLNRYGCMEYVPMMLSKEEEGSLRASAEK 312
Score = 57.6 bits (133), Expect = 3e-07
Identities = 27/54 (50%), Positives = 35/54 (64%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+ +G + + IGSGT+LDSARF L L I S H +IGEHG+S +PVWS
Sbjct: 141 KFSGFPAHSVIGSGTSLDSARFAGELGKHLNIDPRSLHAVVIGEHGESELPVWS 194
>UniRef50_Q4L941 Cluster: L-lactate dehydrogenase; n=1;
Staphylococcus haemolyticus JCSC1435|Rep: L-lactate
dehydrogenase - Staphylococcus haemolyticus (strain
JCSC1435)
Length = 318
Score = 82.2 bits (194), Expect = 1e-14
Identities = 61/204 (29%), Positives = 105/204 (51%), Gaps = 7/204 (3%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQ-- 175
+I +++ D V+ SNPVDI++YV ++S PK+++ +G GT A Q
Sbjct: 103 MIQRIVDSGFDGYFVLPSNPVDIMSYVVKRVSNFPKNKI------IGSGTSLDTARFQFF 156
Query: 176 ARYRYHVLPXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWK-ELHE 340
+ V P S V + IAG + DL + ++ + E +K +
Sbjct: 157 LSREFDVAPNQVYAPIIGEHGDSQVAVWSHAQIAGEPVLDL---LPSNTNLEAFKTSISN 213
Query: 341 NVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLP 520
+ Y++ KG T++ I LSL +IV AIL N N + VS+Y++GE+G+ D V++ +P
Sbjct: 214 RTTQIGYDIYVRKGTTNFGISLSLVRIVEAILFNKNIIMNVSSYVEGEYGLSD-VYIGVP 272
Query: 521 CVLSHCGVSDVIRQPLTELEVAQL 592
V++ G +I L++ E++QL
Sbjct: 273 TVINRNGADRIIELALSKEELSQL 296
Score = 56.8 bits (131), Expect = 5e-07
Identities = 26/54 (48%), Positives = 34/54 (62%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
R++ IGSGT+LD+ARF++ LS +A + IIGEHGDS V VWS
Sbjct: 132 RVSNFPKNKIIGSGTSLDTARFQFFLSREFDVAPNQVYAPIIGEHGDSQVAVWS 185
>UniRef50_Q6KIP9 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
mobile|Rep: L-lactate dehydrogenase - Mycoplasma mobile
Length = 318
Score = 81.0 bits (191), Expect = 3e-14
Identities = 52/183 (28%), Positives = 94/183 (51%), Gaps = 2/183 (1%)
Frame = +2
Query: 38 ILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVLPXXXXX 217
+ ++ +NPVD++T++ +G K+RV + L + L + + H P
Sbjct: 117 VSIVVANPVDVMTFIYQHETGFDKNRV--ISSGTSLDSARLRFEISKKLKVH--PKSVQA 172
Query: 218 XXXXXXXSSMVCINIAGVRLSDLNNQIGTDD--DPENWKELHENVVKSAYEVIKLKGYTS 391
S V + A N+I + + +++H V K AYE+I KG T
Sbjct: 173 FVLGEHGDSSVSVYSAATVSGKSFNEIVKERGISKKELEDMHTTVYKKAYEIINRKGSTY 232
Query: 392 WAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIRQPLT 571
+ IG ++A++V AILT+++++ V YL G++G++D +++ +P VL GV +VI LT
Sbjct: 233 FGIGSTVAELVEAILTDSHAIFGVGVYLTGQYGVKD-LYIGVPTVLGSKGVVEVINFNLT 291
Query: 572 ELE 580
+ E
Sbjct: 292 KEE 294
Score = 54.0 bits (124), Expect = 4e-06
Identities = 25/47 (53%), Positives = 34/47 (72%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA*T 260
I SGT+LDSAR R+ +S +L + S +++GEHGDSSV V+SA T
Sbjct: 144 ISSGTSLDSARLRFEISKKLKVHPKSVQAFVLGEHGDSSVSVYSAAT 190
>UniRef50_A4L2P0 Cluster: L-lactate dehydrogenase; n=4;
Lactobacillus|Rep: L-lactate dehydrogenase -
Lactobacillus reuteri
Length = 312
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/197 (29%), Positives = 94/197 (47%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
II ++K + VI+SNPVDILT + +ISG PK RV L + + +
Sbjct: 106 IIKPIVKSGFTGVFVISSNPVDILTTIAQRISGFPKERVIGTGTSLDSMRLRVLLSKKLH 165
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAY 361
+V+ ++ I I G L+ + TD E+ + V ++
Sbjct: 166 LSVNVIDALMLGEHGDTSFAAFNEITIGGKALNIITALSNTDKS-----EIEKAVHEAGS 220
Query: 362 EVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCG 541
++I KG T + I L+ I RAI+ N N V +S L G++GI D ++L P +++ G
Sbjct: 221 QIIANKGGTFYGIAKCLSYITRAIIENRNLVLPISAPLDGQYGIND-LYLGTPAIINSQG 279
Query: 542 VSDVIRQPLTELEVAQL 592
+ V+ PLT EV ++
Sbjct: 280 IGQVVEYPLTSDEVKKM 296
Score = 45.6 bits (103), Expect = 0.001
Identities = 21/49 (42%), Positives = 31/49 (63%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSS 236
R++G IG+GT+LDS R R LLS +L ++ ++GEHGD+S
Sbjct: 135 RISGFPKERVIGTGTSLDSMRLRVLLSKKLHLSVNVIDALMLGEHGDTS 183
>UniRef50_Q9P7P7 Cluster: Probable L-lactate dehydrogenase; n=2;
Ascomycota|Rep: Probable L-lactate dehydrogenase -
Schizosaccharomyces pombe (Fission yeast)
Length = 330
Score = 80.6 bits (190), Expect = 4e-14
Identities = 62/207 (29%), Positives = 104/207 (50%), Gaps = 10/207 (4%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+ ++ KY+ D IL++A+NPVD+LTY T K++G P RV +G GT+ + AR
Sbjct: 119 ILREVTKYTKDAILLVATNPVDVLTYATLKLTGFPAERV------IGSGTI----IDTAR 168
Query: 182 YRYHV------LPXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKE 331
++Y + P S + + +IAG+ L+D + T D + E
Sbjct: 169 FQYLIGKLYGLDPQSVNADIIGEHGDSELAVWSHASIAGLSLADFCEESETKYDEQALNE 228
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFL 511
+ +AY++I+ KG T + + L +I+ AI+ + N++ VS L I D F
Sbjct: 229 CFKETKNAAYDIIQRKGSTEYGVAAGLVRILAAIIRDENALLTVSG-LDSYSNIGDVCF- 286
Query: 512 SLPCVLSHCGVSDVIRQPLTELEVAQL 592
S+P L+ G +I L++ E A+L
Sbjct: 287 SMPRKLNKDGAHRIINAKLSKDEDAKL 313
Score = 55.6 bits (128), Expect = 1e-06
Identities = 26/54 (48%), Positives = 35/54 (64%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+L G + IGSGT +D+ARF+YL+ G+ S + IIGEHGDS + VWS
Sbjct: 148 KLTGFPAERVIGSGTIIDTARFQYLIGKLYGLDPQSVNADIIGEHGDSELAVWS 201
>UniRef50_P16115 Cluster: L-lactate dehydrogenase; n=4;
Thermotogaceae|Rep: L-lactate dehydrogenase - Thermotoga
maritima
Length = 319
Score = 79.8 bits (188), Expect = 6e-14
Identities = 62/203 (30%), Positives = 101/203 (49%), Gaps = 5/203 (2%)
Frame = +2
Query: 20 KYSPDTILVIASNPVDILTYVTWKISGLPKHRVH---RVRH*LGLGTVPLPAVGQARYRY 190
KY+PD+I+++ +NPVD+LTY K SG+ +V V L T+ G +
Sbjct: 105 KYAPDSIVIVVTNPVDVLTYFFLKESGMDPRKVFGSGTVLDTARLRTLIAQHCGFSPRSV 164
Query: 191 HVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVI 370
HV S + I G+ L ++ QI D + + E ++AYE+I
Sbjct: 165 HVYVIGEHGDSEVPVWSGAM---IGGIPLQNMC-QICQKCDSKILENFAEKTKRAAYEII 220
Query: 371 KLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSD 550
+ KG T +AI L++A IV +I + V +S YL+ G++D + +S+P L GV
Sbjct: 221 ERKGATHYAIALAVADIVESIFFDEKRVLTLSVYLEDYLGVKD-LCISVPVTLGKHGVER 279
Query: 551 VIRQPLT--ELEVAQLSGNLLKS 613
++ L ELE + S ++LK+
Sbjct: 280 ILELNLNEEELEAFRKSASILKN 302
Score = 60.1 bits (139), Expect = 6e-08
Identities = 26/43 (60%), Positives = 31/43 (72%)
Frame = +3
Query: 123 GSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
GSGT LD+AR R L++ G + S H Y+IGEHGDS VPVWS
Sbjct: 139 GSGTVLDTARLRTLIAQHCGFSPRSVHVYVIGEHGDSEVPVWS 181
>UniRef50_Q3ZZJ7 Cluster: Malate dehydrogenase; n=5; cellular
organisms|Rep: Malate dehydrogenase - Dehalococcoides
sp. (strain CBDB1)
Length = 307
Score = 79.4 bits (187), Expect = 9e-14
Identities = 63/203 (31%), Positives = 98/203 (48%), Gaps = 3/203 (1%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
++ +KYSP+ LV+ SNPVD +TY+ WK+SGLP+ RV + L G + A AR
Sbjct: 101 VVSNCLKYSPEATLVVVSNPVDTMTYLAWKLSGLPRKRVVGLSGVLDGGRL---ATFVAR 157
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQ-IGTDDDPENWKELHENVVKSA 358
V P SMV ++ R + +N + + PE EL + V
Sbjct: 158 -ELGVNPSAVSPCVMGEHGGSMVVMS----RFTLVNGKPLSELVSPEKADELAKRAVNGG 212
Query: 359 YEVIK-LK-GYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLS 532
E++ LK G +A S+A +V AI + V + L GE+G+ + + L +P L
Sbjct: 213 AEIVAFLKTGSAFYAPSASVAAMVEAIFLGSGKVMNCAAVLDGEYGLRN-IVLGVPVKLG 271
Query: 533 HCGVSDVIRQPLTELEVAQLSGN 601
G+ ++I PL E A+L +
Sbjct: 272 KGGIKEIITLPLDGQENARLQAS 294
>UniRef50_Q8IX04 Cluster: Ubiquitin-conjugating enzyme E2 variant 3;
n=15; Euteleostomi|Rep: Ubiquitin-conjugating enzyme E2
variant 3 - Homo sapiens (Human)
Length = 471
Score = 79.0 bits (186), Expect = 1e-13
Identities = 37/78 (47%), Positives = 53/78 (67%)
Frame = +2
Query: 356 AYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSH 535
A E++++KG SW++GLS+A +V +I+ N VH+VS KG + I EVFLSLPC+L
Sbjct: 376 AMELLRVKGQRSWSVGLSVADMVDSIVNNKKKVHSVSALAKGYYDINSEVFLSLPCILGT 435
Query: 536 CGVSDVIRQPLTELEVAQ 589
GVS+VI+ L E V +
Sbjct: 436 NGVSEVIKTTLKEDTVTE 453
Score = 50.4 bits (115), Expect = 5e-05
Identities = 20/39 (51%), Positives = 30/39 (76%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRV 118
++P L YS ++L++AS PV+I+TYVTWK+S P +RV
Sbjct: 276 LVPALGHYSQHSVLLVASQPVEIMTYVTWKLSTFPANRV 314
Score = 41.1 bits (92), Expect = 0.028
Identities = 18/44 (40%), Positives = 27/44 (61%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IG G NLDS R +Y++++ L T+ ++IGE G+ V WS
Sbjct: 315 IGIGCNLDSQRLQYIITNVLKAQTSGKEVWVIGEQGEDKVLTWS 358
>UniRef50_P62056 Cluster: L-lactate dehydrogenase; n=2;
Bacteria|Rep: L-lactate dehydrogenase - Treponema
denticola
Length = 315
Score = 78.6 bits (185), Expect = 1e-13
Identities = 65/199 (32%), Positives = 97/199 (48%), Gaps = 11/199 (5%)
Frame = +2
Query: 38 ILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHV------- 196
+++I SNPVDILT K SG + RV +G GTV + AR+RY +
Sbjct: 116 VMLIVSNPVDILTRAALKASGWERGRV------IGSGTV----LDTARFRYTLSKECGVD 165
Query: 197 ---LPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWK-ELHENVVKSAYE 364
+ ++ ++AG R+ + + P K ++ E V SAY
Sbjct: 166 ARNIHGYILGEHGDSEFAAWSMTSVAGRRIDEYCSGGVCSSGPHFDKAKILEEVRNSAYH 225
Query: 365 VIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGV 544
+I KG T +A+GL+L +I AIL N +S+ +VS L GE G++D V LS+PC++ G
Sbjct: 226 IIDYKGSTYFAVGLALTRIAGAILRNEHSILSVSMTLDGEFGLKD-VCLSVPCIVGRSGA 284
Query: 545 SDVIRQPLTELEVAQLSGN 601
VI L E A L +
Sbjct: 285 ERVIESDLPADEQAALEAS 303
Score = 62.9 bits (146), Expect = 8e-09
Identities = 27/44 (61%), Positives = 31/44 (70%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IGSGT LD+ARFRY LS G+ + HGYI+GEHGDS WS
Sbjct: 143 IGSGTVLDTARFRYTLSKECGVDARNIHGYILGEHGDSEFAAWS 186
>UniRef50_A1HSK3 Cluster: Lactate/malate dehydrogenase; n=1;
Thermosinus carboxydivorans Nor1|Rep: Lactate/malate
dehydrogenase - Thermosinus carboxydivorans Nor1
Length = 303
Score = 76.2 bits (179), Expect = 8e-13
Identities = 65/224 (29%), Positives = 113/224 (50%), Gaps = 12/224 (5%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
++ Q + YSP+ I+ + +NP+D++T + +++SGLP +RV +G+GTV + AR
Sbjct: 99 LVRQAVHYSPNCIIFMVTNPLDVMTQLAYQVSGLPANRV------IGMGTV----LDTAR 148
Query: 182 YRYHVL------PXXXXXXXXXXXXSSMVC----INIAGVRLSDLNNQIGTDDDPENWKE 331
YR ++ +MVC I + GV L+ L D
Sbjct: 149 YRSYLAVAFDADARDIDAYVVGEHGETMVCLTSQITVRGVPLTALPGY-----DQAKLAP 203
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFL 511
+ ENVV+++ +VI LKG T +A + ++ AI+ ++ +V V TY ++G V L
Sbjct: 204 IIENVVQASSQVIALKGGTVFAPATAACAVLEAIVRDSRAVLPVCTY-NPQYG----VAL 258
Query: 512 SLPCVLSHCGVSDVIRQPLTELEVAQLSGNL--LKSWLKLRDNL 637
SLP ++ G V+ LT E QL+ ++ +K ++K + L
Sbjct: 259 SLPTIVGRGGAGPVLPLALTAAEQEQLAASVANIKKYVKEMEQL 302
>UniRef50_P59390 Cluster: L-lactate dehydrogenase 2; n=8;
Lactobacillus|Rep: L-lactate dehydrogenase 2 -
Lactobacillus plantarum
Length = 309
Score = 76.2 bits (179), Expect = 8e-13
Identities = 58/183 (31%), Positives = 90/183 (49%)
Frame = +2
Query: 44 VIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVLPXXXXXXX 223
VI+SNPVDILT +T ++SG P+HRV + L T L V A+
Sbjct: 118 VISSNPVDILTSMTQRLSGFPRHRV--IGTGTSLDTARL-RVALAQKLNVATTAVDAAVL 174
Query: 224 XXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKGYTSWAIG 403
SS+V + + L DD + E+ + V ++I KG T + +
Sbjct: 175 GEHGDSSIVNFDEIMINAQPLKTVTTVDDQFK--AEIEQAVRGKGGQIISQKGATFYGVA 232
Query: 404 LSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIRQPLTELEV 583
+SL QI RAIL + N+ VS L G++GI D ++L P +++ G+ VI L++ E
Sbjct: 233 VSLMQICRAILNDENAELIVSAALSGQYGIND-LYLGSPAIINRNGLQKVIEAELSDDER 291
Query: 584 AQL 592
A++
Sbjct: 292 ARM 294
Score = 54.0 bits (124), Expect = 4e-06
Identities = 24/50 (48%), Positives = 35/50 (70%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSV 239
RL+G IG+GT+LD+AR R L+ +L +ATT+ ++GEHGDSS+
Sbjct: 133 RLSGFPRHRVIGTGTSLDTARLRVALAQKLNVATTAVDAAVLGEHGDSSI 182
>UniRef50_P47698 Cluster: L-lactate dehydrogenase; n=2;
Mycoplasma|Rep: L-lactate dehydrogenase - Mycoplasma
genitalium
Length = 312
Score = 75.4 bits (177), Expect = 1e-12
Identities = 60/217 (27%), Positives = 103/217 (47%), Gaps = 9/217 (4%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I ++ K + + +IASNPVDI++Y K++G ++V +G GT+ + AR
Sbjct: 104 IAKEIKKSGFNGVTLIASNPVDIMSYTYLKVTGFEPNKV------IGSGTL----LDSAR 153
Query: 182 YRYHVL-------PXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHE 340
RY + SS+ I+ A + L + D + + E+ +
Sbjct: 154 LRYAIATKYQMSSKDVQAYVIGEHGDSSVSIISSAKIAGLSLKHFSKASDIEKEFGEIDQ 213
Query: 341 NVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLP 520
+ + AYE+I+ KG T + IG + A + IL + V V+ L G++G +D +F P
Sbjct: 214 FIRRRAYEIIERKGATFYGIGEASADVAEQILKDTKEVRVVAPLLTGQYGAKDMMF-GTP 272
Query: 521 CVLSHCGVSDVIRQPLTELEVAQLSGNL--LKSWLKL 625
CVLS G+ ++ L+ E L ++ LK +KL
Sbjct: 273 CVLSRKGIEKILEIELSNTEKVALENSIKVLKDNIKL 309
Score = 52.4 bits (120), Expect = 1e-05
Identities = 24/55 (43%), Positives = 35/55 (63%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
++ G IGSGT LDSAR RY ++ + +++ Y+IGEHGDSSV + S+
Sbjct: 133 KVTGFEPNKVIGSGTLLDSARLRYAIATKYQMSSKDVQAYVIGEHGDSSVSIISS 187
>UniRef50_Q9CGG8 Cluster: L-lactate dehydrogenase 3; n=3;
Lactococcus lactis|Rep: L-lactate dehydrogenase 3 -
Lactococcus lactis subsp. lactis (Streptococcus lactis)
Length = 323
Score = 74.5 bits (175), Expect = 2e-12
Identities = 48/183 (26%), Positives = 86/183 (46%)
Frame = +2
Query: 32 DTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVLPXXX 211
D I ++ASNPVD+L V ++SGLPKHRV L + + + +
Sbjct: 119 DGIFLVASNPVDVLAQVVAEVSGLPKHRVIGTGTLLETSRMRQIVAEKLQINPKSIHGYV 178
Query: 212 XXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKGYTS 391
++ + + + L+ + + P + E+ + + + ++ KG TS
Sbjct: 179 LAEHGKSSFAAWSNVTVGAIPLTTWLKKYPNPEFP-TFDEIDQEIREVGLDIFMQKGNTS 237
Query: 392 WAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIRQPLT 571
+ I SLA++ RAI N + + VS YL GE+G + +++ P ++ GV V+ LT
Sbjct: 238 YGIAASLARLTRAIFRNESVILPVSAYLTGEYG-QFDLYTGSPAIIDRTGVRAVLELELT 296
Query: 572 ELE 580
+ E
Sbjct: 297 QEE 299
Score = 50.0 bits (114), Expect = 6e-05
Identities = 20/44 (45%), Positives = 31/44 (70%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IG+GT L+++R R +++++L I S HGY++ EHG SS WS
Sbjct: 148 IGTGTLLETSRMRQIVAEKLQINPKSIHGYVLAEHGKSSFAAWS 191
>UniRef50_Q8RED8 Cluster: L-lactate dehydrogenase; n=3;
Fusobacterium nucleatum|Rep: L-lactate dehydrogenase -
Fusobacterium nucleatum subsp. nucleatum
Length = 318
Score = 73.7 bits (173), Expect = 4e-12
Identities = 52/194 (26%), Positives = 86/194 (44%), Gaps = 2/194 (1%)
Frame = +2
Query: 5 IPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAV--GQA 178
+P ++K + I V +NPVDI+TY ++SG PK+RV + GL + L +
Sbjct: 104 VPDVVKAGFNGIFVTITNPVDIVTYFVRELSGFPKNRV--IGTGTGLDSARLKRILSEVT 161
Query: 179 RYRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSA 358
V+ ++ I GV D L + VV++A
Sbjct: 162 NIDSQVIQAYMLGEHGDTQIANFSSATIQGVPFLDYMKTHPEQFKGVELSVLEKQVVRTA 221
Query: 359 YEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHC 538
+++I K T + IG + + +V+AI N V S YL GE+G + +P ++
Sbjct: 222 WDIISGKNCTEFGIGCTCSNLVKAIFHNERRVLPCSAYLNGEYG-HSGFYTGVPAIIGSN 280
Query: 539 GVSDVIRQPLTELE 580
GV +++ PL E E
Sbjct: 281 GVEEILELPLDERE 294
Score = 46.0 bits (104), Expect = 0.001
Identities = 22/56 (39%), Positives = 34/56 (60%)
Frame = +3
Query: 93 LAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA*T 260
L+G IG+GT LDSAR + +LS+ I + Y++GEHGD+ + +S+ T
Sbjct: 133 LSGFPKNRVIGTGTGLDSARLKRILSEVTNIDSQVIQAYMLGEHGDTQIANFSSAT 188
>UniRef50_Q185V1 Cluster: L-lactate dehydrogenase; n=3;
Clostridium|Rep: L-lactate dehydrogenase - Clostridium
difficile (strain 630)
Length = 322
Score = 72.1 bits (169), Expect = 1e-11
Identities = 59/217 (27%), Positives = 97/217 (44%), Gaps = 5/217 (2%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LG---LGTVPLPAVG 172
I+ ++ D I V+ SNPVD++T W+ SG PK++V L L + G
Sbjct: 110 IVKPIVDSGFDGIFVVISNPVDVVTNYIWEKSGFPKNKVIGTGTALDSTRLRRILSEETG 169
Query: 173 QARYRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVK 352
A+ S ++I G + D+ + + + E K
Sbjct: 170 IAQQSIQAYSMGEHGDSQMVPWSH---VSIGGKPILDMIKDNPSIYSNLDLPSIVEKNKK 226
Query: 353 SAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLS 532
+ +I K T + IG +L +IV+AIL N V VST L+G++ E VF +PCV+
Sbjct: 227 TGISIINGKDCTEFGIGTALVEIVKAILHNEKKVLPVSTLLEGQYN-ERNVFAGVPCVIG 285
Query: 533 HCGVSDVIRQPLTELEVAQL--SGNLLKSWLKLRDNL 637
G+ +I +TE E + S ++L+ ++ L L
Sbjct: 286 KDGIEQIIEINMTEYEQNEFNKSCSVLREYIALSKTL 322
Score = 52.8 bits (121), Expect = 8e-06
Identities = 24/44 (54%), Positives = 29/44 (65%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IG+GT LDS R R +LS+ GIA S Y +GEHGDS + WS
Sbjct: 149 IGTGTALDSTRLRRILSEETGIAQQSIQAYSMGEHGDSQMVPWS 192
>UniRef50_A6NLX8 Cluster: L-lactate dehydrogenase; n=4;
Eutheria|Rep: L-lactate dehydrogenase - Homo sapiens
(Human)
Length = 253
Score = 69.7 bits (163), Expect = 7e-11
Identities = 28/44 (63%), Positives = 36/44 (81%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IGSG NLD+ RF++ + +LGI + SC G+I+GEHGDSSVPVWS
Sbjct: 208 IGSGCNLDTVRFQFFIGQKLGIHSESCRGWILGEHGDSSVPVWS 251
Score = 51.6 bits (118), Expect = 2e-05
Identities = 22/39 (56%), Positives = 29/39 (74%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRV 118
+I +++ SP L+I SNPVDILTYV WK+S PK+RV
Sbjct: 169 MISSIVQQSPLCKLIIVSNPVDILTYVAWKLSAFPKNRV 207
>UniRef50_A1U9V0 Cluster: Lactate/malate dehydrogenase; n=6;
Actinomycetales|Rep: Lactate/malate dehydrogenase -
Mycobacterium sp. (strain KMS)
Length = 329
Score = 69.3 bits (162), Expect = 9e-11
Identities = 62/212 (29%), Positives = 100/212 (47%), Gaps = 13/212 (6%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
+ PQL+++SPD +++ +NPVD++TY + ++ G GTV + +R
Sbjct: 118 LTPQLLEHSPDAVVIFVTNPVDVVTYAASSVVDAQPGQI------FGTGTV----LDSSR 167
Query: 182 YRY-------------HVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPEN 322
+RY H L S++ I G ++ ++ D+
Sbjct: 168 FRYLVAQRAAIAVGNVHALVIGEHGDSEIPLWSTL-SIGGVGADAYRVDGRLVFDEPTRT 226
Query: 323 WKELHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDE 502
+ +VV +AYE+I KG T+ AIGL+ A++V A+L + + V VST G +GI
Sbjct: 227 --AVATDVVNAAYEIIAGKGATNLAIGLATARVVEAVLGDQHRVLPVSTVQDGAYGITG- 283
Query: 503 VFLSLPCVLSHCGVSDVIRQPLTELEVAQLSG 598
V LSLP V+S G V+ EL +L G
Sbjct: 284 VALSLPTVVSAGGARRVLE---VELSPGELDG 312
Score = 62.1 bits (144), Expect = 1e-08
Identities = 25/43 (58%), Positives = 33/43 (76%)
Frame = +3
Query: 123 GSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
G+GT LDS+RFRYL++ R IA + H +IGEHGDS +P+WS
Sbjct: 158 GTGTVLDSSRFRYLVAQRAAIAVGNVHALVIGEHGDSEIPLWS 200
>UniRef50_Q64P62 Cluster: Malate dehydrogenase; n=28;
Bacteroidetes|Rep: Malate dehydrogenase - Bacteroides
fragilis
Length = 313
Score = 69.3 bits (162), Expect = 9e-11
Identities = 55/205 (26%), Positives = 96/205 (46%), Gaps = 5/205 (2%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
+ L+KYSP+ I+V+ SNP+D +TY+ K GLPK+RV +G+G A+ +R
Sbjct: 103 VAENLLKYSPNAIIVVISNPMDTMTYLALKSLGLPKNRV------IGMG----GALDSSR 152
Query: 182 YRY---HVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQ-IGTDDDPENWKELHENVV 349
++Y L I RL+ Q + T E E+ + +
Sbjct: 153 FKYFLSQALGCNANEVEGMVIGGHGDTTMIPLARLATYKGQPVSTLLSEEKLNEVVASTM 212
Query: 350 KSAYEVIKLKGYTSW-AIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCV 526
+ KL G ++W A G + A +V +I+ N + S L+GE+G E ++ + +P +
Sbjct: 213 VGGATLTKLLGTSAWYAPGAAGAYVVESIIHNQKKMVPCSVMLEGEYG-ESDLCIGVPVI 271
Query: 527 LSHCGVSDVIRQPLTELEVAQLSGN 601
L G+ ++ L E A+ + +
Sbjct: 272 LGKNGIEKIVELELNADEKAKFAAS 296
Score = 43.6 bits (98), Expect = 0.005
Identities = 19/40 (47%), Positives = 25/40 (62%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSV 239
IG G LDS+RF+Y LS LG G +IG HGD+++
Sbjct: 142 IGMGGALDSSRFKYFLSQALGCNANEVEGMVIGGHGDTTM 181
>UniRef50_A3JXA9 Cluster: L-lactate dehydrogenase; n=1; Sagittula
stellata E-37|Rep: L-lactate dehydrogenase - Sagittula
stellata E-37
Length = 300
Score = 68.9 bits (161), Expect = 1e-10
Identities = 62/212 (29%), Positives = 101/212 (47%), Gaps = 10/212 (4%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
++ + + +PD IL+IASNPVDI+T+VT +SGLP RV +G GT+ + AR
Sbjct: 90 VVGDVTRAAPDAILLIASNPVDIMTHVTQALSGLPAGRV------IGSGTI----LDTAR 139
Query: 182 YRY------HVLPXXXXXXXXXXXXSSMV----CINIAGVRLSDLNNQIGTDDDPENWKE 331
+R+ ++ P + V V + QI + +
Sbjct: 140 FRWLLGRHLNIAPRSVHAYVLGEHGDTEVLAWTAARAGSVSIESFAAQIRAPLTADVRER 199
Query: 332 LHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFL 511
+ + V +AY +I+ KG T + IG LA++V AI ++ +V VST L G+ V
Sbjct: 200 IDKGVRNAAYTIIEGKGATWYGIGAGLARLVAAIGSDEQTVLTVST-LSDVAGVR-RVAC 257
Query: 512 SLPCVLSHCGVSDVIRQPLTELEVAQLSGNLL 607
SLP V+ GV+ + ++ E A L + +
Sbjct: 258 SLPRVVGREGVTAELMPDISRQENAALEASAM 289
Score = 63.3 bits (147), Expect = 6e-09
Identities = 29/54 (53%), Positives = 37/54 (68%)
Frame = +3
Query: 93 LAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
L+G + IGSGT LD+ARFR+LL L IA S H Y++GEHGD+ V W+A
Sbjct: 120 LSGLPAGRVIGSGTILDTARFRWLLGRHLNIAPRSVHAYVLGEHGDTEVLAWTA 173
>UniRef50_A7DRG3 Cluster: Lactate/malate dehydrogenase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
Lactate/malate dehydrogenase - Candidatus Nitrosopumilus
maritimus SCM1
Length = 304
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/196 (27%), Positives = 94/196 (47%), Gaps = 3/196 (1%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPL---PAVG 172
++ + KY+ D++++ +NP+D + Y+T+K+SG + RV + L L A G
Sbjct: 100 VVENVKKYADDSMIIPVTNPLDPMAYITYKVSGFDRSRVFGMGGMLDLSRFRQFIHEATG 159
Query: 173 QARYRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVK 352
+R L +++G+ L L + E +EL +N +
Sbjct: 160 HSRDSIRALVIGEHGENMLPLPRFS---SVSGIPLPSLLPK-------EKLEELVQNTKQ 209
Query: 353 SAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLS 532
A +VI+LKG T A G +++ IV A++ + V V+TYL GE+ D V + +P V+
Sbjct: 210 VAAKVIELKGATVHAPGNAISAIVEAVVRDRKQVIPVATYLDGEYDHSD-VTIGVPAVIG 268
Query: 533 HCGVSDVIRQPLTELE 580
GV +I L + E
Sbjct: 269 KNGVEKIIELDLNDEE 284
Score = 36.7 bits (81), Expect = 0.59
Identities = 16/52 (30%), Positives = 29/52 (55%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 245
+++G + G G LD +RFR + + G + S +IGEHG++ +P+
Sbjct: 129 KVSGFDRSRVFGMGGMLDLSRFRQFIHEATGHSRDSIRALVIGEHGENMLPL 180
>UniRef50_A3ZZ88 Cluster: L-lactate/malate dehydrogenase; n=1;
Blastopirellula marina DSM 3645|Rep: L-lactate/malate
dehydrogenase - Blastopirellula marina DSM 3645
Length = 308
Score = 67.3 bits (157), Expect = 4e-10
Identities = 53/194 (27%), Positives = 83/194 (42%)
Frame = +2
Query: 5 IPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARY 184
IP L SP I V+ +NPVD++T+ ++SG P+ RV V L T L + R+
Sbjct: 102 IPILAAASPQAICVMVTNPVDVMTWFALQLSGFPQERVFGVG--TLLDTARLRRLLSERW 159
Query: 185 RYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYE 364
H +A + L + D + L +SA +
Sbjct: 160 SVHASDVRAYVIGEHGEDQ------VASFSSASLGGEAMKPSD--DLASLARQAAESAGK 211
Query: 365 VIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGV 544
+ + +G+T++ I + I+ +I N VS + HG+ D V LSLP V+ G+
Sbjct: 212 IYRTRGFTNYGIAGATMMILESIRNNRRRTAPVSMRINNYHGVSD-VCLSLPAVIGRRGI 270
Query: 545 SDVIRQPLTELEVA 586
V+R L E E A
Sbjct: 271 ERVLRPELNEAEQA 284
Score = 46.4 bits (105), Expect = 7e-04
Identities = 22/55 (40%), Positives = 32/55 (58%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
+L+G G GT LD+AR R LLS+R + + Y+IGEHG+ V +S+
Sbjct: 130 QLSGFPQERVFGVGTLLDTARLRRLLSERWSVHASDVRAYVIGEHGEDQVASFSS 184
>UniRef50_Q7UY63 Cluster: L-lactate/malate dehydrogenase; n=2;
Planctomycetaceae|Rep: L-lactate/malate dehydrogenase -
Rhodopirellula baltica
Length = 304
Score = 66.9 bits (156), Expect = 5e-10
Identities = 59/195 (30%), Positives = 89/195 (45%), Gaps = 1/195 (0%)
Frame = +2
Query: 5 IPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARY 184
+P L K SP+ I+V+ SNPVD L Y T +++G RV +G GT+ V RY
Sbjct: 102 MPGLAKASPNAIVVMVSNPVDALAYETIRLTGFDPKRV------IGTGTL----VDSIRY 151
Query: 185 RYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENW-KELHENVVKSAY 361
R +L + S + G P + + + E Y
Sbjct: 152 RA-LLSTELKIHAQDIRAYILGEHGDTQFAASSIAMTGGERFYPSDTSRRMFEETKAMGY 210
Query: 362 EVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCG 541
EV +LKG+TS+ I ++ I+ +I + VS + G G+ED V LSLP V+ G
Sbjct: 211 EVFRLKGHTSYGIAMATITILDSIAYDLRHTMPVSVLVDGYLGVED-VCLSLPAVIGREG 269
Query: 542 VSDVIRQPLTELEVA 586
V+ ++ L+E E A
Sbjct: 270 VTRILHPTLSEDEEA 284
Score = 45.6 bits (103), Expect = 0.001
Identities = 23/48 (47%), Positives = 28/48 (58%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDS 233
RL G IG+GT +DS R+R LLS L I YI+GEHGD+
Sbjct: 130 RLTGFDPKRVIGTGTLVDSIRYRALLSTELKIHAQDIRAYILGEHGDT 177
>UniRef50_A2UB98 Cluster: Lactate/malate dehydrogenase precursor;
n=2; Bacteria|Rep: Lactate/malate dehydrogenase
precursor - Bacillus coagulans 36D1
Length = 327
Score = 66.1 bits (154), Expect = 8e-10
Identities = 43/199 (21%), Positives = 92/199 (46%), Gaps = 2/199 (1%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
++ + KY+ + +++ +NP+D + Y+ G K R+ L + L +
Sbjct: 109 VMAGITKYTKEAVIIFITNPLDTIVYIAENEFGYSKGRIFGTG--TMLDSARLRQLVAEN 166
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVC--INIAGVRLSDLNNQIGTDDDPENWKELHENVVKS 355
Y + V +N+ G R +L++ + +P + + + VVK+
Sbjct: 167 YSIDPKSVTGYMMGEHGFTAFPVFSRLNVQGFREKELDS-VFKGKEPLDREAFRQKVVKT 225
Query: 356 AYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSH 535
A++V+ KG+T+ + + + +A++ + S++ VS L G++G +V LS+P V+
Sbjct: 226 AFDVLNGKGWTNAGVAEAAVTLAKAVMLDEKSIYPVSATLHGQYGYNGDVALSIPSVIGR 285
Query: 536 CGVSDVIRQPLTELEVAQL 592
G+ + L E E + L
Sbjct: 286 NGIEQQLEIELDEQETSWL 304
Score = 46.4 bits (105), Expect = 7e-04
Identities = 21/43 (48%), Positives = 30/43 (69%)
Frame = +3
Query: 123 GSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
G+GT LDSAR R L+++ I S GY++GEHG ++ PV+S
Sbjct: 149 GTGTMLDSARLRQLVAENYSIDPKSVTGYMMGEHGFTAFPVFS 191
>UniRef50_Q8VMZ6 Cluster: L-lactate dehydrogenase; n=1; Listeria
grayi|Rep: L-lactate dehydrogenase - Listeria grayi
(Listeria murrayi)
Length = 126
Score = 65.3 bits (152), Expect = 1e-09
Identities = 30/87 (34%), Positives = 55/87 (63%)
Frame = +2
Query: 341 NVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLP 520
+V +AYE+I KG T + I +LA+I +AIL N N++ +S YL G +G++D +++ P
Sbjct: 26 SVRDAAYEIINKKGATFYGIAAALARITQAILNNENAILPLSVYLDGHYGLKD-IYIGAP 84
Query: 521 CVLSHCGVSDVIRQPLTELEVAQLSGN 601
V++ GV ++ L++ E Q++ +
Sbjct: 85 AVVNRKGVRHIVEMKLSDTEQEQMNAS 111
>UniRef50_A6Q7S2 Cluster: Malate dehydrogenase, NAD-dependent; n=1;
Sulfurovum sp. NBC37-1|Rep: Malate dehydrogenase,
NAD-dependent - Sulfurovum sp. (strain NBC37-1)
Length = 320
Score = 64.9 bits (151), Expect = 2e-09
Identities = 55/207 (26%), Positives = 93/207 (44%), Gaps = 9/207 (4%)
Frame = +2
Query: 11 QLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRY 190
++ +Y+PD I+++ SNP+D++TYV K +G P+ RV LG+ + L A A + Y
Sbjct: 108 EIKEYAPDAIVIVVSNPLDVMTYVALKETGFPRQRV------LGMAGI-LDAARMAHFIY 160
Query: 191 HVL---PXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKELHENVV 349
L +MV + +AGV + DL D E E+
Sbjct: 161 EKLEYGAGQIRATVMGGHGDTMVPLPKFTTVAGVPIEDLL-------DSEEIGEIVRKTR 213
Query: 350 KSAYEVIKLKGYTS--WAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPC 523
E++ L G S +A S +V AIL + N +H+ + LK ++G D + +P
Sbjct: 214 NGGAEIVNLLGDGSAYYAPAKSTTVMVEAILKDTNQIHSCAIMLKNDYGYSD-IVSGVPV 272
Query: 524 VLSHCGVSDVIRQPLTELEVAQLSGNL 604
++ G VI L L+ + ++
Sbjct: 273 MIGAGGAEKVINMTLKPLQQTRFKNSV 299
>UniRef50_P50933 Cluster: L-lactate dehydrogenase; n=7;
Bacteria|Rep: L-lactate dehydrogenase - Deinococcus
radiodurans
Length = 304
Score = 64.9 bits (151), Expect = 2e-09
Identities = 27/45 (60%), Positives = 34/45 (75%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
IGSGT LDSARFR+L++ G+ T HGY++GEHGDS V WS+
Sbjct: 136 IGSGTVLDSARFRHLMAQHAGVDGTHAHGYVLGEHGDSEVLAWSS 180
Score = 50.4 bits (115), Expect = 5e-05
Identities = 50/198 (25%), Positives = 87/198 (43%), Gaps = 1/198 (0%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKIS-GLPKHRVHRVRH*LGLGTVPLPAVGQA 178
++PQ+ + +PD +L++ SNPVD+LT + +++ G P V + G
Sbjct: 99 LVPQITRAAPDAVLLVTSNPVDLLTDLATQLAPGQPVIGSGTVLDSARFRHLMAQHAGVD 158
Query: 179 RYRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSA 358
H SS + +AG+ ++D + + ++ E +A
Sbjct: 159 GTHAHGYVLGEHGDSEVLAWSSAM---VAGMPVADFMQAQNLPWNEQVRAKIDEGTRNAA 215
Query: 359 YEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHC 538
+I+ K T + IG +LA+I A+L + +V VS E+G+ LSLP V+
Sbjct: 216 ASIIEGKRATYYGIGAALARITEAVLRDRRAVLTVSAPTP-EYGVS----LSLPRVVGRQ 270
Query: 539 GVSDVIRQPLTELEVAQL 592
GV + LT E +L
Sbjct: 271 GVLSTLHPKLTGDEQQKL 288
>UniRef50_Q9P4B6 Cluster: L-lactate dehydrogenase A; n=48; Rhizopus
oryzae|Rep: L-lactate dehydrogenase A - Rhizopus oryzae
(Rhizopus delemar)
Length = 320
Score = 64.1 bits (149), Expect = 3e-09
Identities = 59/198 (29%), Positives = 88/198 (44%), Gaps = 10/198 (5%)
Frame = +2
Query: 29 PDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYH----- 193
PD ++++ +NPVDILT++ +SGLP ++V +G GT + R R H
Sbjct: 111 PDAVILVVANPVDILTHIAKTLSGLPPNQV------IGSGTY----LDTTRLRVHLGDVF 160
Query: 194 -VLPXXXXXXXXXXXXSSMV----CINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSA 358
V P S + +I G L+ D + + + A
Sbjct: 161 DVNPQSVHAFVLGEHGDSQMIAWEAASIGGQPLTSFPEFAKLDKTA-----ISKAISGKA 215
Query: 359 YEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHC 538
E+I+LKG T + IG A +V I+ N SVH VS Y++ ++G S+P L
Sbjct: 216 MEIIRLKGATFYGIGACAADLVHTIMLNRKSVHPVSVYVE-KYG----ATFSMPAKLGWR 270
Query: 539 GVSDVIRQPLTELEVAQL 592
GV + PLTE E A L
Sbjct: 271 GVEQIYEVPLTEEEEALL 288
Score = 50.8 bits (116), Expect = 3e-05
Identities = 23/54 (42%), Positives = 30/54 (55%)
Frame = +3
Query: 93 LAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
L+G IGSGT LD+ R R L D + S H +++GEHGDS + W A
Sbjct: 132 LSGLPPNQVIGSGTYLDTTRLRVHLGDVFDVNPQSVHAFVLGEHGDSQMIAWEA 185
>UniRef50_A4E9T4 Cluster: Putative uncharacterized protein; n=1;
Collinsella aerofaciens ATCC 25986|Rep: Putative
uncharacterized protein - Collinsella aerofaciens ATCC
25986
Length = 325
Score = 63.3 bits (147), Expect = 6e-09
Identities = 59/206 (28%), Positives = 94/206 (45%), Gaps = 4/206 (1%)
Frame = +2
Query: 32 DTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVLPXXX 211
D I V SNP D++ W ++G ++ + GL + L + + V P
Sbjct: 116 DGIFVSISNPCDVVCTELWHLTGYDPKKI--IGSGCGLDSARLRT--EISKKVGVSPKSV 171
Query: 212 XXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLK 379
S + IAG L++L + D + E+ E K Y + K
Sbjct: 172 DAYMIGEHGFSQLAAFKAATIAGKSLNELQAE-NPDKYAFDHMEVEELARKGGYVTYQGK 230
Query: 380 GYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIR 559
T +A+ S A++ A+L N ++V + ST + G++G E+ +F SLPCV+ GV +V
Sbjct: 231 QCTEYAVANSAARVCAAVLHNEHAVLSASTLMTGQYG-EEGIFTSLPCVIGAEGVEEVYT 289
Query: 560 QPLTELEVAQLSGNLLKSWLKLRDNL 637
L+E E L G L KS +RDN+
Sbjct: 290 LDLSEHE---LEG-LHKSCQHIRDNI 311
Score = 46.4 bits (105), Expect = 7e-04
Identities = 24/56 (42%), Positives = 32/56 (57%)
Frame = +3
Query: 93 LAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA*T 260
L G IGSG LDSAR R +S ++G++ S Y+IGEHG S + + A T
Sbjct: 136 LTGYDPKKIIGSGCGLDSARLRTEISKKVGVSPKSVDAYMIGEHGFSQLAAFKAAT 191
>UniRef50_P59050 Cluster: L-lactate dehydrogenase 1; n=3;
Bifidobacterium longum|Rep: L-lactate dehydrogenase 1 -
Bifidobacterium longum
Length = 316
Score = 63.3 bits (147), Expect = 6e-09
Identities = 47/187 (25%), Positives = 84/187 (44%)
Frame = +2
Query: 32 DTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVLPXXX 211
D ++V+ SNPVD++ + WK SGLP+ +V L + + +
Sbjct: 116 DGVIVMVSNPVDVMAWYAWKRSGLPRTQVLGTGTALDTSRLKTIIGEETGLDPRNVGGFV 175
Query: 212 XXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKGYTS 391
++ +++ G + + E+ E E++ KG T+
Sbjct: 176 MGEHGDSQFTAWSTVSLGGKPFARFLADNQDRFASVSTTEIEEKTRTRGNEIVAAKGGTN 235
Query: 392 WAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIRQPLT 571
+ I ++A IV+ IL + + VST L GE+G E +VFL +P L G ++++ L+
Sbjct: 236 FGIASTVAGIVQTILWDERRIVPVSTLLDGEYG-EHDVFLGVPTELRANGANEIVELDLS 294
Query: 572 ELEVAQL 592
E E A+L
Sbjct: 295 EDERAKL 301
Score = 47.6 bits (108), Expect = 3e-04
Identities = 18/52 (34%), Positives = 32/52 (61%)
Frame = +3
Query: 96 AGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+G T +G+GT LD++R + ++ + G+ + G+++GEHGDS WS
Sbjct: 137 SGLPRTQVLGTGTALDTSRLKTIIGEETGLDPRNVGGFVMGEHGDSQFTAWS 188
>UniRef50_A4A2L6 Cluster: L-lactate dehydrogenase; n=4;
Bacteria|Rep: L-lactate dehydrogenase - Blastopirellula
marina DSM 3645
Length = 313
Score = 62.1 bits (144), Expect = 1e-08
Identities = 61/202 (30%), Positives = 90/202 (44%), Gaps = 5/202 (2%)
Frame = +2
Query: 32 DTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTV--PLPAVGQARYRYHVLPX 205
D I + SNPVDILTY+ + LP RV +GLGT + + P
Sbjct: 112 DAICFVVSNPVDILTYLAAQRLNLPTSRV------IGLGTQLDTIRFRALIAQEMKLPPT 165
Query: 206 XXXXXXXXXXXSSMVCI-NIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKG 382
SM+ + + A V L+ G P EL S EVIK KG
Sbjct: 166 QVKALILGEHGDSMLPVWSAATVNGLPLDKFPGWT--PNKATELFTRTRGSGAEVIKKKG 223
Query: 383 YTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIRQ 562
+A+G+++ ++ AI + N V VS+ G +GI + V LS+P ++ GV+
Sbjct: 224 GAGFAVGIAIRDVIEAIALDKNQVLPVSSVQNGCYGIRN-VALSVPTLVGRDGVAGTFEV 282
Query: 563 PLTELEVAQL--SGNLLKSWLK 622
L E+ QL SG +L+ L+
Sbjct: 283 DLWPKEMQQLRHSGQVLRQTLE 304
Score = 54.0 bits (124), Expect = 4e-06
Identities = 24/47 (51%), Positives = 31/47 (65%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA*T 260
IG GT LD+ RFR L++ + + T I+GEHGDS +PVWSA T
Sbjct: 141 IGLGTQLDTIRFRALIAQEMKLPPTQVKALILGEHGDSMLPVWSAAT 187
>UniRef50_Q6ABQ3 Cluster: L-lactate dehydrogenase; n=1;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 322
Score = 61.7 bits (143), Expect = 2e-08
Identities = 37/112 (33%), Positives = 61/112 (54%)
Frame = +2
Query: 257 NIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAIL 436
+I G+ L++ +G P + ++ +VV+SA+++++ KG+TS I + + RA+L
Sbjct: 196 SIGGLTLAEATTALGLQ--PLSPDQVGNSVVQSAFDILEGKGWTSSGISKAAVSLARAML 253
Query: 437 TNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIRQPLTELEVAQL 592
+ S+H V T G G EV LSLP V+S GV + L E E +L
Sbjct: 254 LDQRSIHPVCTLADGVLGFHSEVSLSLPTVVSGHGVEHHLNIVLDEWEQEKL 305
Score = 44.4 bits (100), Expect = 0.003
Identities = 25/66 (37%), Positives = 38/66 (57%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA*T*REYASVISTIRS 299
+G+GT LDSAR R L+D G++ S +++GEHG ++ P S +AS+ +
Sbjct: 150 VGTGTALDSARLRRHLADWAGVSPDSVQAFMLGEHGATAFPYLS------HASIGGLTLA 203
Query: 300 EPTTIL 317
E TT L
Sbjct: 204 EATTAL 209
>UniRef50_Q8TWG5 Cluster: Malate dehydrogenase; n=2;
Euryarchaeota|Rep: Malate dehydrogenase - Methanopyrus
kandleri
Length = 317
Score = 61.7 bits (143), Expect = 2e-08
Identities = 53/191 (27%), Positives = 90/191 (47%), Gaps = 5/191 (2%)
Frame = +2
Query: 26 SPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGT----VPLPAVGQARYRYH 193
+P+ I+++ +NPVD+LTYV K+SGLPK+RV +GLGT + + + H
Sbjct: 113 NPEAIVLVVTNPVDVLTYVALKVSGLPKNRV------IGLGTHLDSMRFKVLIAKHFNVH 166
Query: 194 VLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIK 373
+ + + I+ V + G +D + +E V ++ +I+
Sbjct: 167 -MSEVHTRIIGEHGDTMVPVISSTSVGGIPVTRMPGWED--FDVEEAVREVKEAGQRIIE 223
Query: 374 LKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGE-HGIEDEVFLSLPCVLSHCGVSD 550
G + + ++ +VR IL + V VS YL GE GI D V + +P L GV +
Sbjct: 224 TWGGSQFGPAQAITNLVRTILQDERRVLTVSAYLDGEIDGIRD-VCIGVPARLGREGVLE 282
Query: 551 VIRQPLTELEV 583
++ L E E+
Sbjct: 283 IVPIELEEDEM 293
Score = 50.4 bits (115), Expect = 5e-05
Identities = 23/55 (41%), Positives = 34/55 (61%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
+++G IG GT+LDS RF+ L++ + + H IIGEHGD+ VPV S+
Sbjct: 134 KVSGLPKNRVIGLGTHLDSMRFKVLIAKHFNVHMSEVHTRIIGEHGDTMVPVISS 188
>UniRef50_Q59G78 Cluster: Lactate dehydrogenase B variant; n=1; Homo
sapiens|Rep: Lactate dehydrogenase B variant - Homo
sapiens (Human)
Length = 129
Score = 61.3 bits (142), Expect = 2e-08
Identities = 26/42 (61%), Positives = 35/42 (83%)
Frame = +2
Query: 353 SAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLK 478
SAYEVIKLKGYT+WAIGLS+A ++ ++L N + +H VST +K
Sbjct: 14 SAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVK 55
>UniRef50_A0RXX8 Cluster: Malate/L-lactate dehydrogenase; n=1;
Cenarchaeum symbiosum|Rep: Malate/L-lactate
dehydrogenase - Cenarchaeum symbiosum
Length = 302
Score = 61.3 bits (142), Expect = 2e-08
Identities = 52/196 (26%), Positives = 91/196 (46%), Gaps = 3/196 (1%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPL---PAVG 172
++ ++ +++ D++++ +NP+D +TY+ +K SG K+RV + L L A G
Sbjct: 100 VVEKVKEHAKDSMIIPVTNPLDPITYIAYKTSGFEKNRVFGMGGMLDLSRFRQFIHEATG 159
Query: 173 QARYRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVK 352
+R L ++G+ L L + E EL + K
Sbjct: 160 YSRDSIRALVMGEHGENMLPLPRFST---VSGIPLLSLISA-------EKAAELVRDTKK 209
Query: 353 SAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLS 532
A +VI+LKG T A G S++ +V +I+ + V VS YL+GE+G V + +P V+
Sbjct: 210 VAAKVIELKGATVHAPGNSISAMVESIVRDKKQVIPVSAYLEGEYG-HSGVTIGVPAVIG 268
Query: 533 HCGVSDVIRQPLTELE 580
GV ++ L E
Sbjct: 269 RKGVEKIVELDLDGAE 284
Score = 35.9 bits (79), Expect = 1.0
Identities = 15/52 (28%), Positives = 27/52 (51%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 245
+ +G G G LD +RFR + + G + S ++GEHG++ +P+
Sbjct: 129 KTSGFEKNRVFGMGGMLDLSRFRQFIHEATGYSRDSIRALVMGEHGENMLPL 180
>UniRef50_UPI000038D9FF Cluster: COG0039: Malate/lactate
dehydrogenases; n=2; Nostoc punctiforme PCC 73102|Rep:
COG0039: Malate/lactate dehydrogenases - Nostoc
punctiforme PCC 73102
Length = 317
Score = 60.9 bits (141), Expect = 3e-08
Identities = 47/183 (25%), Positives = 80/183 (43%), Gaps = 3/183 (1%)
Frame = +2
Query: 5 IPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQ--- 175
I +L + +P++I++I SNPVD+LT + S ++ + L + Q
Sbjct: 107 IKELDRVAPNSIVIIISNPVDVLTRIAQATSTRAENLIFGSGTVLDTARLRYQLGKQLNV 166
Query: 176 ARYRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKS 355
A+ H SS I G+ L++ G + + +E + K
Sbjct: 167 AKQDIHAYVIGEHGDSQFVVWSSAF---IGGILLTEFPIPQGATLE-QIQQEYAQLTRKR 222
Query: 356 AYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSH 535
Y + + KGYTS+ I + Q+V IL + + VST +G+ EV L LPC++
Sbjct: 223 GYNIFERKGYTSYGISTVVCQLVDTILRDEKQIFPVSTRADSNYGVGSEVVLGLPCIIGS 282
Query: 536 CGV 544
G+
Sbjct: 283 TGI 285
Score = 58.0 bits (134), Expect = 2e-07
Identities = 25/44 (56%), Positives = 30/44 (68%)
Frame = +3
Query: 123 GSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
GSGT LD+AR RY L +L +A H Y+IGEHGDS VWS+
Sbjct: 146 GSGTVLDTARLRYQLGKQLNVAKQDIHAYVIGEHGDSQFVVWSS 189
>UniRef50_O08349 Cluster: Malate dehydrogenase; n=1; Archaeoglobus
fulgidus|Rep: Malate dehydrogenase - Archaeoglobus
fulgidus
Length = 294
Score = 60.9 bits (141), Expect = 3e-08
Identities = 51/210 (24%), Positives = 104/210 (49%), Gaps = 3/210 (1%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGT-VPLPAVGQA 178
I ++++ +P++ +++ +NP+D++TY+ WK SG P++ V G+G + + +
Sbjct: 101 IAKKIVENAPESKILVVTNPMDVMTYIMWKESGKPRNEV------FGMGNQLDSQRLKER 154
Query: 179 RYRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSA 358
Y S V ++A D + ++ +W+ + +V A
Sbjct: 155 LYNAGARNIRRAWIIGEHGDSMFVAKSLA-----DFDGEV-------DWEAVENDVRFVA 202
Query: 359 YEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHC 538
EVIK KG T + +++ ++V+A++ + + S L+GE+GIE+ V + +P L
Sbjct: 203 AEVIKRKGATIFGPAVAIYRMVKAVVEDTGEIIPTSMILQGEYGIEN-VAVGVPAKLGKN 261
Query: 539 G--VSDVIRQPLTELEVAQLSGNLLKSWLK 622
G V+D I+ E+E + S +L+ L+
Sbjct: 262 GAEVAD-IKLSDEEIEKLRNSAKILRERLE 290
>UniRef50_A3EWH3 Cluster: Malate/lactate dehydrogenase; n=1;
Leptospirillum sp. Group II UBA|Rep: Malate/lactate
dehydrogenase - Leptospirillum sp. Group II UBA
Length = 320
Score = 60.5 bits (140), Expect = 4e-08
Identities = 51/222 (22%), Positives = 107/222 (48%), Gaps = 10/222 (4%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
+ ++ K++PD+++++ +NP+D++ Y+ WK++G P+ RV +G+G A+ +R
Sbjct: 106 VAEKIRKHAPDSVVIMVTNPMDLMAYILWKVTGFPRERV------IGMG----GALDSSR 155
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVCINIAG--VRLSDLNNQIGTD----DDPENWKELHEN 343
+ Y V +MV V L + + G DP+ ++L
Sbjct: 156 FAYFV---SEVTNTSVSNIQTMVMGGHGDDMVPLLEFSTIAGVSLKKALDPDVLQKLVAR 212
Query: 344 VVKSAYEVIKLKGYTS--WAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSL 517
E+++L +S +A ++ ++ +IL + + V S YL+GE+G++ VF +
Sbjct: 213 TRDGGGEIVRLMKDSSAYFAPAAAIYSMIESILHDRHRVIPSSVYLEGEYGVKG-VFSGV 271
Query: 518 PCVLSHCGVSDVIRQPLT--ELEVAQLSGNLLKSWLKLRDNL 637
P + + G+ ++ PL+ E E S ++ ++ D L
Sbjct: 272 PVQIGNIGLEKIVLLPLSAEEEEAFHRSTESIRQGIRTIDRL 313
Score = 37.5 bits (83), Expect = 0.34
Identities = 16/42 (38%), Positives = 25/42 (59%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 245
IG G LDS+RF Y +S+ + ++ ++G HGD VP+
Sbjct: 145 IGMGGALDSSRFAYFVSEVTNTSVSNIQTMVMGGHGDDMVPL 186
>UniRef50_O67655 Cluster: Malate dehydrogenase 1; n=3; Bacteria|Rep:
Malate dehydrogenase 1 - Aquifex aeolicus
Length = 335
Score = 60.1 bits (139), Expect = 6e-08
Identities = 52/208 (25%), Positives = 99/208 (47%), Gaps = 15/208 (7%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I ++ +Y+PD I+++ +NPVD++TYV +K+ PK+RV +G+ V + AR
Sbjct: 117 IADRIKRYAPDAIVIVVTNPVDVMTYVAYKLLNFPKNRV------MGMAGV----LDSAR 166
Query: 182 YR------YHVLPXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKE 331
++ V P MV + N+ G+ L DL + E ++
Sbjct: 167 FKTFISEELMVSPKDIHAYVIGGHGDEMVPLISISNVGGIPLKDLLPK-------EKLEK 219
Query: 332 LHENVVKSAYEVIKLKGYTS-WAIGLSLAQIVRAILTNANSVHAVSTYLKGE----HGIE 496
+ E E++ L G ++ +A ++ ++ A++ N+ + S YL GE +G++
Sbjct: 220 IIERTRFGGGEIVNLMGTSAYYAPAAAIVDMIEALVQNSKRILPCSVYLDGEAGEYYGVQ 279
Query: 497 DEVFLSLPCVLSHCGVSDVIRQPLTELE 580
+ +P L GV ++I+ P+ E E
Sbjct: 280 G-FCVGVPVKLGSNGVEEIIKVPMIEEE 306
Score = 43.6 bits (98), Expect = 0.005
Identities = 19/44 (43%), Positives = 27/44 (61%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+G LDSARF+ +S+ L ++ H Y+IG HGD VP+ S
Sbjct: 156 MGMAGVLDSARFKTFISEELMVSPKDIHAYVIGGHGDEMVPLIS 199
>UniRef50_A0LRV1 Cluster: Lactate/malate dehydrogenase; n=3;
Actinomycetales|Rep: Lactate/malate dehydrogenase -
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Length = 330
Score = 58.8 bits (136), Expect = 1e-07
Identities = 59/210 (28%), Positives = 94/210 (44%), Gaps = 13/210 (6%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVH---------RVRH*LG--LG 148
+ + KY+P ++++ SNP+D +T +T ++G PK+RV R H + LG
Sbjct: 119 VAENIAKYAPSAVVIVVSNPLDEMTALTQLVTGFPKNRVMGQAGMLDTARFSHFVAEELG 178
Query: 149 TVPLPAVGQARYRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWK 328
VP+ AV H V I+ RL+DL PE +
Sbjct: 179 -VPIRAVRTLTLGSH------GDTMVPVPSQCFVTIDGEQRRLADLV-------PPEKIQ 224
Query: 329 ELHENVVKSAYEVIKL--KGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDE 502
EL E E++ L G +A + A++ RA+ ++ V V ++ GE+GI
Sbjct: 225 ELVERTRNGGGEIVALLKTGSAYFAPSAAAARMARAVAEDSGQVLPVCAWVDGEYGIHG- 283
Query: 503 VFLSLPCVLSHCGVSDVIRQPLTELEVAQL 592
V+L + + GV V+ PLTE E+A L
Sbjct: 284 VYLGVEAEIGAQGVRRVVTTPLTESELAAL 313
Score = 37.5 bits (83), Expect = 0.34
Identities = 15/42 (35%), Positives = 25/42 (59%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 245
+G LD+ARF + +++ LG+ + +G HGD+ VPV
Sbjct: 158 MGQAGMLDTARFSHFVAEELGVPIRAVRTLTLGSHGDTMVPV 199
>UniRef50_Q9EVR0 Cluster: L-lactate dehydrogenase; n=1; Selenomonas
ruminantium|Rep: L-lactate dehydrogenase - Selenomonas
ruminantium
Length = 318
Score = 58.8 bits (136), Expect = 1e-07
Identities = 46/204 (22%), Positives = 101/204 (49%), Gaps = 7/204 (3%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
++ +++K + + ++++ +NP+D+ TYV P++ + LG GT+ L R
Sbjct: 107 VMGEIVKRTKEAMIIMITNPLDVATYVVSTQFDYPRNLI------LGTGTM-LETYRFRR 159
Query: 182 Y---RYHVLPXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKELHE 340
+Y V P ++ AG + DL+ + + + + +
Sbjct: 160 ILADKYQVDPKNINGYVLGEHGNAAFVAWSTTGCAGFPIDDLDEYFHRTEKLSH-EAVEQ 218
Query: 341 NVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLP 520
+V+ AY+VI KG+T+ I ++ + ++++L + +++ S L+GE+GI+D V LS+P
Sbjct: 219 ELVQVAYDVINKKGFTNTGIAMAACRFIKSVLYDEHTILPCSAVLEGEYGIKD-VALSIP 277
Query: 521 CVLSHCGVSDVIRQPLTELEVAQL 592
++ G+ LT+ E+ ++
Sbjct: 278 RMVCADGIMRSFEVHLTDDELEKM 301
Score = 47.2 bits (107), Expect = 4e-04
Identities = 17/44 (38%), Positives = 32/44 (72%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+G+GT L++ RFR +L+D+ + + +GY++GEHG+++ WS
Sbjct: 146 LGTGTMLETYRFRRILADKYQVDPKNINGYVLGEHGNAAFVAWS 189
>UniRef50_Q98PG4 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
pulmonis|Rep: L-lactate dehydrogenase - Mycoplasma
pulmonis
Length = 315
Score = 58.8 bits (136), Expect = 1e-07
Identities = 25/44 (56%), Positives = 34/44 (77%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+ SGT LD++RFR LS++ G+ T S HG++IGEHGD SV V+S
Sbjct: 141 MSSGTFLDTSRFRKFLSEKTGVPTNSVHGFVIGEHGDKSVVVFS 184
>UniRef50_O26290 Cluster: Malate dehydrogenase; n=2;
Methanobacteriaceae|Rep: Malate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 325
Score = 58.4 bits (135), Expect = 2e-07
Identities = 45/186 (24%), Positives = 85/186 (45%), Gaps = 4/186 (2%)
Frame = +2
Query: 11 QLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRY 190
Q+ +++PD+I+++ +NPVD++TYV + SG RV + + L ++ L +
Sbjct: 107 QIARFAPDSIILVVTNPVDVMTYVALRYSGFHPSRVFGLGN--HLDSLRLKNYMARHFNV 164
Query: 191 HV--LPXXXXXXXXXXXXSSMVCINIAGVRLSD-LNNQIGTDDDPENWKELHENVVKSAY 361
HV + + +I G+ + + + K+ + V+ +
Sbjct: 165 HVSEVHTRVIGQHGPYMVPLISSTSIGGIPIEHYARRDYFSGYKKFDLKKTIDKVIHAGS 224
Query: 362 EVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGE-HGIEDEVFLSLPCVLSHC 538
+I KG T + +++ IV IL + + VST ++GE GI D V L +P L
Sbjct: 225 NIISRKGATEYGPAFAISNIVTTILNDERRILTVSTLMEGEIDGIRD-VCLGVPVKLGKN 283
Query: 539 GVSDVI 556
G+ V+
Sbjct: 284 GIEGVV 289
Score = 35.1 bits (77), Expect = 1.8
Identities = 16/55 (29%), Positives = 28/55 (50%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
R +G + G G +LDS R + ++ + + H +IG+HG VP+ S+
Sbjct: 133 RYSGFHPSRVFGLGNHLDSLRLKNYMARHFNVHVSEVHTRVIGQHGPYMVPLISS 187
>UniRef50_Q18WQ6 Cluster: Malate dehydrogenase, NAD-dependent; n=2;
Desulfitobacterium hafniense|Rep: Malate dehydrogenase,
NAD-dependent - Desulfitobacterium hafniense (strain
DCB-2)
Length = 320
Score = 58.0 bits (134), Expect = 2e-07
Identities = 51/190 (26%), Positives = 95/190 (50%), Gaps = 5/190 (2%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
++ Q++++SP++ L+I SNPVDI+TYV +K SG ++R+ +G V + AR
Sbjct: 103 VVRQVVQHSPNSTLIILSNPVDIMTYVAFKESGFKRNRI------IGQSGV----LDSAR 152
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVCIN--IAGVRLSDLNNQIGTDDDPE-NWKELHENVVK 352
+RY V V + + VR ++ PE +++ E +
Sbjct: 153 FRYFVASELKVSAEDVTGFVLGVHGDDMVPLVRYCSVHGIPIQQLLPEAEIEKIMERTRQ 212
Query: 353 SAYEVIKLKGYTS--WAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCV 526
+ E++ L G S +A +L +++ +IL + + V +L+GE G +D V L++P V
Sbjct: 213 AGSEIVNLLGNGSAYYAPAAALTEMIESILLDKHRVMPCIVHLEGELGYQDLV-LNVPAV 271
Query: 527 LSHCGVSDVI 556
+ GV ++
Sbjct: 272 IGRQGVEKIL 281
Score = 44.4 bits (100), Expect = 0.003
Identities = 19/50 (38%), Positives = 28/50 (56%)
Frame = +3
Query: 96 AGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 245
+G IG LDSARFRY ++ L ++ G+++G HGD VP+
Sbjct: 134 SGFKRNRIIGQSGVLDSARFRYFVASELKVSAEDVTGFVLGVHGDDMVPL 183
>UniRef50_Q4UJ29 Cluster: L-lactate dehydrogenase, putative; n=2;
Theileria|Rep: L-lactate dehydrogenase, putative -
Theileria annulata
Length = 367
Score = 58.0 bits (134), Expect = 2e-07
Identities = 50/196 (25%), Positives = 91/196 (46%), Gaps = 9/196 (4%)
Frame = +2
Query: 20 KYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARY---RY 190
KY+P+ +++ +NP+D++ ++ K++G PK+ V +G+G + L + Y +
Sbjct: 163 KYAPEAFVIVITNPMDVMVHLMLKVTGFPKNMV------VGMGGL-LDSSRMNCYIAEKL 215
Query: 191 HVLPXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKELHENVVKSA 358
V P SM+ + + G+ + Q E+ KE+ E V SA
Sbjct: 216 GVNPKYVHGSVIGAHGDSMIPLVSRSTVYGIPILQFVEQGYIT--MEDIKEIEERTVTSA 273
Query: 359 YEVIKLKGYTS--WAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLS 532
+E++KL G S +A + ++ + L + V S YL+G++G D ++ P V+
Sbjct: 274 FEILKLYGSGSSYFAPATAAIEMASSYLNDKKCVFPCSCYLEGQYGHRD-IYCGTPAVIG 332
Query: 533 HCGVSDVIRQPLTELE 580
GV V LT E
Sbjct: 333 ANGVEKVFELKLTPEE 348
Score = 44.4 bits (100), Expect = 0.003
Identities = 19/54 (35%), Positives = 31/54 (57%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
++ G +G G LDS+R ++++LG+ HG +IG HGDS +P+ S
Sbjct: 186 KVTGFPKNMVVGMGGLLDSSRMNCYIAEKLGVNPKYVHGSVIGAHGDSMIPLVS 239
>UniRef50_Q27743 Cluster: L-lactate dehydrogenase; n=17;
Apicomplexa|Rep: L-lactate dehydrogenase - Plasmodium
falciparum (isolate CDC / Honduras)
Length = 316
Score = 58.0 bits (134), Expect = 2e-07
Identities = 51/198 (25%), Positives = 92/198 (46%), Gaps = 8/198 (4%)
Frame = +2
Query: 20 KYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARY---RY 190
K P+ +++ +NPVD++ + + SG+PK+++ +GLG V L Y +
Sbjct: 115 KNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKI------IGLGGV-LDTSRLKYYISQKL 167
Query: 191 HVLPXXXXXXXXXXXXSSMVC----INIAGVRLSD-LNNQIGTDDDPENWKELHENVVKS 355
+V P + MV I + G+ L + +NN++ +D + E + + V +
Sbjct: 168 NVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELE---AIFDRTVNT 224
Query: 356 AYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSH 535
A E++ L A ++ ++ + L + V ST L+G++G D +F P VL
Sbjct: 225 ALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSD-IFGGTPVVLGA 283
Query: 536 CGVSDVIRQPLTELEVAQ 589
GV VI L E A+
Sbjct: 284 NGVEQVIELQLNSEEKAK 301
Score = 36.7 bits (81), Expect = 0.59
Identities = 15/48 (31%), Positives = 26/48 (54%)
Frame = +3
Query: 96 AGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSV 239
+G IG G LD++R +Y +S +L + + +I+G HG+ V
Sbjct: 140 SGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMV 187
>UniRef50_Q1FMY2 Cluster: L-lactate dehydrogenase; n=1; Clostridium
phytofermentans ISDg|Rep: L-lactate dehydrogenase -
Clostridium phytofermentans ISDg
Length = 319
Score = 57.6 bits (133), Expect = 3e-07
Identities = 35/109 (32%), Positives = 58/109 (53%)
Frame = +2
Query: 254 INIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAI 433
++IAG + +L + + +L + + ++ KG T + IG SLA++ RAI
Sbjct: 190 VSIAGKPILELIKEKPEKYGQIDLSKLSDEARAGGWHILTGKGSTEFGIGASLAEVTRAI 249
Query: 434 LTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIRQPLTELE 580
++ V VST L GE+G + +V+ S+P VL GV ++I LT E
Sbjct: 250 FSDEKKVLPVSTLLNGEYG-QHDVYASVPTVLGIHGVEEIIELNLTPEE 297
Score = 46.8 bits (106), Expect = 6e-04
Identities = 20/48 (41%), Positives = 30/48 (62%)
Frame = +3
Query: 108 STAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
S I + T LDSAR R ++D + I S +G+++GEHG+S + WS
Sbjct: 141 SNKIISTSTVLDSARLRRAIADAVEIDQKSIYGFVLGEHGESQMVAWS 188
>UniRef50_Q6JH30 Cluster: Lactate dehydrogenase; n=3; Plasmodium
(Plasmodium)|Rep: Lactate dehydrogenase - Plasmodium
vivax
Length = 299
Score = 57.6 bits (133), Expect = 3e-07
Identities = 48/192 (25%), Positives = 89/192 (46%), Gaps = 8/192 (4%)
Frame = +2
Query: 29 PDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARY---RYHVL 199
P+ +++ +NPVD++ + ++ SG+PK+++ +GLG V L Y + +V
Sbjct: 111 PNAFIIVVTNPVDVMVQLLFEHSGVPKNKI------IGLGGV-LDTSRLKYYISQKLNVC 163
Query: 200 PXXXXXXXXXXXXSSMVC----INIAGVRLSD-LNNQIGTDDDPENWKELHENVVKSAYE 364
P + MV I + G+ L + +NN+ TD++ E + + V +A E
Sbjct: 164 PRDVNALIVGAHGNKMVLLKRYITVGGIPLQEFINNKKITDEEVEG---IFDRTVNTALE 220
Query: 365 VIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGV 544
++ L A ++ ++ + L + V ST L+G++G +F P V+ GV
Sbjct: 221 IVNLLASPYVAPAAAIIEMAESYLKDIKKVLVCSTLLEGQYG-HSNIFGGTPLVIGGTGV 279
Query: 545 SDVIRQPLTELE 580
VI L E
Sbjct: 280 EQVIELQLNAEE 291
Score = 35.5 bits (78), Expect = 1.4
Identities = 15/48 (31%), Positives = 25/48 (52%)
Frame = +3
Query: 96 AGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSV 239
+G IG G LD++R +Y +S +L + + I+G HG+ V
Sbjct: 133 SGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNALIVGAHGNKMV 180
>UniRef50_A2SSY4 Cluster: L-lactate dehydrogenase; n=3;
Methanomicrobiales|Rep: L-lactate dehydrogenase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 319
Score = 57.6 bits (133), Expect = 3e-07
Identities = 46/180 (25%), Positives = 87/180 (48%), Gaps = 2/180 (1%)
Frame = +2
Query: 11 QLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRY 190
Q+ + +P+ IL++ +NPVDI+T V K SG+ HRV + L ++ L A +
Sbjct: 108 QVGRMAPEAILLVVTNPVDIMTTVALKYSGMMPHRVFGLG--THLDSMRLKACLAEFFNV 165
Query: 191 HV--LPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYE 364
HV + + G++ ++N +G P +E+ + V S
Sbjct: 166 HVSEIHTRIIGEHGDTMVPMWSATTVGGIQ---IDNLLGVAKLPR--EEMIQRVKSSGSY 220
Query: 365 VIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGV 544
+I+ KG T + G ++A ++R I+ + N + V+T ++ E + V +S+P ++ GV
Sbjct: 221 IIEAKGATVYGPGDAIATLIRTIVEDENRMLTVATQIRREVFGHEGVCVSVPARITRGGV 280
Score = 51.2 bits (117), Expect = 3e-05
Identities = 23/57 (40%), Positives = 34/57 (59%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA*T 260
+ +G + G GT+LDS R + L++ + + H IIGEHGD+ VP+WSA T
Sbjct: 134 KYSGMMPHRVFGLGTHLDSMRLKACLAEFFNVHVSEIHTRIIGEHGDTMVPMWSATT 190
>UniRef50_Q6F0L9 Cluster: L-lactate dehydrogenase; n=6;
Mollicutes|Rep: L-lactate dehydrogenase - Mesoplasma
florum (Acholeplasma florum)
Length = 317
Score = 57.6 bits (133), Expect = 3e-07
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 6/200 (3%)
Frame = +2
Query: 5 IPQLIKYSP-DTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I + IK S + + VIASNP D+LT V +++G +H V +G GT L + R
Sbjct: 105 IAEAIKASGFNGVTVIASNPCDVLTTVYQQVTGYDEHSV------VGAGTT-LDSARLRR 157
Query: 182 Y---RYHVLPXXXXXXXXXXXX-SSMVCINIAGVRLSDLNNQIGTDDDPE-NWKELHENV 346
+ +V P SS+ + A V ++ + E + +E
Sbjct: 158 LVAEKLNVAPKSVNAYIMGEHGDSSVAAYSKATVMGQPISKYLAEGKITEADLEECWTRA 217
Query: 347 VKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCV 526
++ AYE+I+ KG T + IG+ L I AIL + + V L GE+G + + +P +
Sbjct: 218 IRMAYEIIERKGATYYGIGVCLNAISSAILRDEKTTFMVGAKLNGEYG-QKGFYTGVPVI 276
Query: 527 LSHCGVSDVIRQPLTELEVA 586
L G +I L++ E A
Sbjct: 277 LGSKGWETIIEWDLSDAEKA 296
Score = 56.4 bits (130), Expect = 7e-07
Identities = 24/44 (54%), Positives = 34/44 (77%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+G+GT LDSAR R L++++L +A S + YI+GEHGDSSV +S
Sbjct: 144 VGAGTTLDSARLRRLVAEKLNVAPKSVNAYIMGEHGDSSVAAYS 187
>UniRef50_Q3J7E7 Cluster: Malate dehydrogenase; n=5;
Gammaproteobacteria|Rep: Malate dehydrogenase -
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Length = 311
Score = 57.2 bits (132), Expect = 4e-07
Identities = 47/198 (23%), Positives = 91/198 (45%), Gaps = 2/198 (1%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+ +++++P ++++I +NPVD+LTY W+ G + RV L + G+
Sbjct: 104 IMNNVMRFAPQSLVMIVTNPVDVLTYHAWRHCGWDRARVFGQAGVLDSARMASFIAGETG 163
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAY 361
+ + I+G+ L+ +Q + +++ E +
Sbjct: 164 LSVKDISAMVLGGHGDTMLPLIRYTTISGIPLTHFLDQ-------QVIEKIIERTRHGGF 216
Query: 362 EVIKLKGYTSW--AIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSH 535
E+++L+ +S A ++A +V AI N + L+GE+G E+EV + +P VL
Sbjct: 217 EILRLRQTSSAYDAPAAAIAGMVDAIRHNRKRILPCVAILQGEYG-ENEVAMGVPSVLGG 275
Query: 536 CGVSDVIRQPLTELEVAQ 589
G+ ++ PLTE E Q
Sbjct: 276 DGLERIVELPLTEEEQEQ 293
>UniRef50_Q87JV1 Cluster: Lactate dehydrogenase; n=4; Vibrio|Rep:
Lactate dehydrogenase - Vibrio parahaemolyticus
Length = 317
Score = 56.8 bits (131), Expect = 5e-07
Identities = 33/88 (37%), Positives = 48/88 (54%)
Frame = +2
Query: 329 ELHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVF 508
EL E V ++ YE+ + K T I S+ +I++AI N SV V T + G++G+ V
Sbjct: 209 ELLEAVKQAGYEIFRRKHNTVHGIAASVFRIIQAIKINERSVLPVGTMMSGQYGVSG-VV 267
Query: 509 LSLPCVLSHCGVSDVIRQPLTELEVAQL 592
LSLP V+ G V+ P TE E+ L
Sbjct: 268 LSLPTVVGKKGAESVLTHPFTEEELETL 295
Score = 34.3 bits (75), Expect = 3.2
Identities = 13/36 (36%), Positives = 24/36 (66%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHG 227
I SG +D+AR ++++R+ + + GY++GEHG
Sbjct: 141 ISSGCVIDTARLMSIVANRVDLDPKNIFGYVLGEHG 176
>UniRef50_Q8YJE7 Cluster: Malate dehydrogenase; n=98; Bacteria|Rep:
Malate dehydrogenase - Brucella melitensis
Length = 320
Score = 56.4 bits (130), Expect = 7e-07
Identities = 53/202 (26%), Positives = 91/202 (45%), Gaps = 12/202 (5%)
Frame = +2
Query: 20 KYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRY--- 190
KY+P+ ++ +NP+D + + K SGLP H+V +G+ V + AR+RY
Sbjct: 109 KYAPEAFVICITNPLDAMVWALQKFSGLPAHKV------VGMAGV----LDSARFRYFLS 158
Query: 191 ---HVLPXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKELHENVV 349
+V SMV + +AG+ LSDL T D ++ +
Sbjct: 159 EEFNVSVEDVTAFVLGGHGDSMVPLARYSTVAGIPLSDLVKMGWTSQD--KLDKIIQRTR 216
Query: 350 KSAYEVIKL--KGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPC 523
E++ L G +A S Q+ + L + V V+ L G++G++D +++ +P
Sbjct: 217 DGGAEIVGLLKTGSAFYAPAASAIQMAESYLKDKKRVLPVAAQLSGQYGVKD-MYVGVPT 275
Query: 524 VLSHCGVSDVIRQPLTELEVAQ 589
V+ GV +I L + E AQ
Sbjct: 276 VIGANGVERIIEIDLDKDEKAQ 297
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/52 (36%), Positives = 30/52 (57%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 245
+ +G + +G LDSARFRY LS+ ++ +++G HGDS VP+
Sbjct: 132 KFSGLPAHKVVGMAGVLDSARFRYFLSEEFNVSVEDVTAFVLGGHGDSMVPL 183
>UniRef50_P0C0J4 Cluster: L-lactate dehydrogenase; n=5; Mycoplasma
hyopneumoniae|Rep: L-lactate dehydrogenase - Mycoplasma
hyopneumoniae
Length = 315
Score = 56.0 bits (129), Expect = 9e-07
Identities = 47/181 (25%), Positives = 75/181 (41%)
Frame = +2
Query: 38 ILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVLPXXXXX 217
I +I +NPVDI+T SG +V L + +A+ + +
Sbjct: 115 ISIIVANPVDIITRAYRDASGFSDQKVIGSGTVLDTARLQFAIAKRAKVSPNSVQAYVMG 174
Query: 218 XXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKGYTSWA 397
+ I IAG + G D KEL V + AYE+I K T +
Sbjct: 175 EHGDSSFVAYSNIKIAGECFCAYSKLTGIDSSNYE-KELEYPVSRRAYEIINRKRATFYG 233
Query: 398 IGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIRQPLTEL 577
IG ++A+IV I+ + ++ L+GE+G V + +P VL G+ +I L +
Sbjct: 234 IGAAIAKIVSNIIKDTKNIMIAGANLRGEYGFHG-VNIGVPVVLGANGIEKIIEISLNDK 292
Query: 578 E 580
E
Sbjct: 293 E 293
Score = 47.6 bits (108), Expect = 3e-04
Identities = 20/44 (45%), Positives = 30/44 (68%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IGSGT LD+AR ++ ++ R ++ S Y++GEHGDSS +S
Sbjct: 142 IGSGTVLDTARLQFAIAKRAKVSPNSVQAYVMGEHGDSSFVAYS 185
>UniRef50_Q92BI0 Cluster: L-lactate dehydrogenase 2; n=18;
Bacteria|Rep: L-lactate dehydrogenase 2 - Listeria
innocua
Length = 311
Score = 56.0 bits (129), Expect = 9e-07
Identities = 25/54 (46%), Positives = 35/54 (64%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+L+G +G+G LD+ R R LL+++L IA S +I+GEHGDS PVWS
Sbjct: 133 KLSGLPREQVLGTGVWLDTTRLRRLLAEKLDIAAQSIDAFILGEHGDSQFPVWS 186
Score = 47.6 bits (108), Expect = 3e-04
Identities = 19/39 (48%), Positives = 29/39 (74%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRV 118
I+P+++K I +IA+NP DI+TY WK+SGLP+ +V
Sbjct: 104 IVPEMMKGGFKGIFLIATNPCDIITYQVWKLSGLPREQV 142
>UniRef50_A7I5J9 Cluster: L-lactate dehydrogenase precursor; n=1;
Candidatus Methanoregula boonei 6A8|Rep: L-lactate
dehydrogenase precursor - Methanoregula boonei (strain
6A8)
Length = 332
Score = 55.6 bits (128), Expect = 1e-06
Identities = 50/181 (27%), Positives = 89/181 (49%), Gaps = 5/181 (2%)
Frame = +2
Query: 26 SPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVLPX 205
+PDT +++ +NPVD++T V K SGL ++V + L ++ L ++ + ++ HV
Sbjct: 113 APDTKIIMVTNPVDVMTCVALKYSGLKPNQVFGLG--THLDSMRLKSLIASYFKVHV--S 168
Query: 206 XXXXXXXXXXXSSMV----CINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIK 373
SMV I G+++S+L ++ ++V S ++IK
Sbjct: 169 EVHTRIIGEHGDSMVPLWSATTIGGIKISNLPAFAHLP-----VQDFIQSVKTSGEQIIK 223
Query: 374 LKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGE-HGIEDEVFLSLPCVLSHCGVSD 550
KG T + G ++A +V+ IL + N + VS Y+K E HGI V + +P ++ G
Sbjct: 224 NKGSTVYGPGEAIATLVKTILGDENRILTVSAYVKSEVHGI-GGVCIGVPARINKNGAFP 282
Query: 551 V 553
V
Sbjct: 283 V 283
Score = 51.6 bits (118), Expect = 2e-05
Identities = 24/57 (42%), Positives = 33/57 (57%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA*T 260
+ +G G GT+LDS R + L++ + + H IIGEHGDS VP+WSA T
Sbjct: 134 KYSGLKPNQVFGLGTHLDSMRLKSLIASYFKVHVSEVHTRIIGEHGDSMVPLWSATT 190
>UniRef50_Q92AZ3 Cluster: Lin1775 protein; n=13; Listeria|Rep:
Lin1775 protein - Listeria innocua
Length = 302
Score = 55.2 bits (127), Expect = 2e-06
Identities = 50/197 (25%), Positives = 86/197 (43%), Gaps = 4/197 (2%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I+P+++ I V +NP D++T + KISG RV L + VG+A
Sbjct: 102 IVPKILATGFKGIFVNITNPCDVITMLIQKISGFDHSRVFGTGTSLDTARM-RRVVGEA- 159
Query: 182 YRYHVLPXXXXXXXXXXXXSSMV----CINIAGVRLSDLNNQIGTDDDPENWKELHENVV 349
H+ P S + I GV ++D + P + L + V
Sbjct: 160 --LHINPKSIEGYVLGEHGESQFVAWSTVKIGGVNITDYKTK-----TPLDLPALKDAVR 212
Query: 350 KSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVL 529
+ ++ KG+TS+ I + A IV A+LT+A V ++ + + + ++ P ++
Sbjct: 213 GGGWNILTGKGWTSFGIATATAGIVDALLTDAKQVFPLAVFSE-----QTNTYIGQPALI 267
Query: 530 SHCGVSDVIRQPLTELE 580
GV D I+ PLT+ E
Sbjct: 268 GANGVLDTIKPPLTKEE 284
Score = 51.6 bits (118), Expect = 2e-05
Identities = 23/58 (39%), Positives = 36/58 (62%)
Frame = +3
Query: 78 MLRGRLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
ML +++G + G+GT+LD+AR R ++ + L I S GY++GEHG+S WS
Sbjct: 127 MLIQKISGFDHSRVFGTGTSLDTARMRRVVGEALHINPKSIEGYVLGEHGESQFVAWS 184
>UniRef50_Q0UX88 Cluster: L-lactate dehydrogenase; n=2;
Phaeosphaeria nodorum|Rep: L-lactate dehydrogenase -
Phaeosphaeria nodorum (Septoria nodorum)
Length = 326
Score = 55.2 bits (127), Expect = 2e-06
Identities = 22/54 (40%), Positives = 36/54 (66%)
Frame = +3
Query: 93 LAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
++G +G+GT+LDSAR R +L+ + G++ +S Y++GEHGDS WS+
Sbjct: 134 MSGLPENQVLGTGTSLDSARLRGVLAGKAGVSPSSIDAYVLGEHGDSQFVAWSS 187
Score = 50.4 bits (115), Expect = 5e-05
Identities = 53/176 (30%), Positives = 80/176 (45%), Gaps = 3/176 (1%)
Frame = +2
Query: 26 SPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPA--VGQARYRYHVL 199
S T+L++ +NPVDIL Y +SGLP+++V LG GT A G + V
Sbjct: 112 SAHTVLLLVANPVDILVYFARMMSGLPENQV------LGTGTSLDSARLRGVLAGKAGVS 165
Query: 200 P-XXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKL 376
P S V + A + + L +G + E +E+ +A +I
Sbjct: 166 PSSIDAYVLGEHGDSQFVAWSSASIGTTPLRLALGDELTDEFKEEVAMKTRGAAGAIIAA 225
Query: 377 KGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGV 544
KG TS+ IG A I R IL ++ +V +S + + E G LS+P VL G+
Sbjct: 226 KGCTSYGIGNVAASICRHILFDSRTVRPLS-FFQPELG----CCLSMPAVLGRRGI 276
>UniRef50_Q03BE6 Cluster: L-lactate dehydrogenase; n=1;
Lactobacillus casei ATCC 334|Rep: L-lactate
dehydrogenase - Lactobacillus casei (strain ATCC 334)
Length = 312
Score = 54.4 bits (125), Expect = 3e-06
Identities = 24/43 (55%), Positives = 28/43 (65%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 248
+GSGT LDSAR R + R + HGYI+GEHGDS PVW
Sbjct: 142 LGSGTALDSARLRSEIGLRYNVDARIVHGYIMGEHGDSEFPVW 184
>UniRef50_Q07841 Cluster: Malate dehydrogenase; n=7;
Halobacteriaceae|Rep: Malate dehydrogenase - Haloarcula
marismortui (Halobacterium marismortui)
Length = 304
Score = 53.2 bits (122), Expect = 6e-06
Identities = 24/44 (54%), Positives = 30/44 (68%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IG G LDSARFRY+LS+ + G I+GEHGD+ VPV+S
Sbjct: 142 IGFGGRLDSARFRYVLSEEFDAPVQNVEGTILGEHGDAQVPVFS 185
Score = 52.0 bits (119), Expect = 1e-05
Identities = 52/191 (27%), Positives = 85/191 (44%), Gaps = 2/191 (1%)
Frame = +2
Query: 14 LIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYH 193
L +++ D I + SNPVD+L ++ + +V +G G + AR+RY
Sbjct: 107 LDEHNDDYISLTTSNPVDLLNRHLYEAGDRSREQV------IGFGG----RLDSARFRY- 155
Query: 194 VLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDD--PENWKELHENVVKSAYEV 367
VL + + A V + GTD + + ++L ++ +SA +V
Sbjct: 156 VLSEEFDAPVQNVEGTILGEHGDAQVPVFSKVRVDGTDPEFSGDEKEQLLGDLQESAMDV 215
Query: 368 IKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVS 547
I+ KG T W +A +V AIL + V S L+GE G ED F +P L GV
Sbjct: 216 IERKGATEWGPARGVAHMVEAILHDTGEVLPASVKLEGEFGHEDTAF-GVPVRLGSNGVE 274
Query: 548 DVIRQPLTELE 580
+++ L + E
Sbjct: 275 EIVEWDLDDYE 285
>UniRef50_Q7NHJ3 Cluster: Malate dehydrogenase; n=13; cellular
organisms|Rep: Malate dehydrogenase - Gloeobacter
violaceus
Length = 325
Score = 52.8 bits (121), Expect = 8e-06
Identities = 44/199 (22%), Positives = 84/199 (42%), Gaps = 2/199 (1%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
+ + + +SP+ +V+ +NP+D +++V W+ SGL RV + L +
Sbjct: 108 VTQKAVAHSPEATVVVVTNPLDAMSHVAWRASGLVPERVMGMAGVLDAARFETFIAWELG 167
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAY 361
+ + I+GV L+ L + D L E
Sbjct: 168 FSVRDIRAMVLGGHGDLMVPLPRYTTISGVPLTQLLSSARID-------ALIERTRTGGA 220
Query: 362 EVIKL--KGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSH 535
E++ L +G +A + A+++ +L + + V+ YL GE+G+ + + + +P +LS
Sbjct: 221 EIVHLLKRGGAYYAPAAAAARMIETLLGDERRLLPVAAYLSGEYGLRN-IHMGVPVILSR 279
Query: 536 CGVSDVIRQPLTELEVAQL 592
GV V+ L E A L
Sbjct: 280 HGVERVVELTLETEEKAAL 298
Score = 35.1 bits (77), Expect = 1.8
Identities = 16/52 (30%), Positives = 26/52 (50%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 245
R +G + +G LD+ARF ++ LG + ++G HGD VP+
Sbjct: 137 RASGLVPERVMGMAGVLDAARFETFIAWELGFSVRDIRAMVLGGHGDLMVPL 188
>UniRef50_A7DSJ4 Cluster: Lactate/malate dehydrogenase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
Lactate/malate dehydrogenase - Candidatus Nitrosopumilus
maritimus SCM1
Length = 303
Score = 51.6 bits (118), Expect = 2e-05
Identities = 48/217 (22%), Positives = 100/217 (46%), Gaps = 5/217 (2%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I ++ KY P I+++ SNP+D+LTY K +G + +V +G+ + ++ +R
Sbjct: 100 IAKKIKKYCPSAIVLLVSNPLDVLTYFFQKTTGFSRFKV------IGIAS----SLDTSR 149
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDP-----ENWKELHENV 346
+RY++ S+ + + G + + + + D+P ++ + +NV
Sbjct: 150 FRYYI---SETLSVPQSSVSNALVLGEHGDSMVPIFSGVSVGDNPLFSMIDSRDTITDNV 206
Query: 347 VKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCV 526
+ K + + I ++ +V AI S L GE+ E +V + +P +
Sbjct: 207 RNYWRTLRNFKSRSQFGIAKNVFDVVDAIRNKKEISIPASVVLDGEYD-EHDVAMGIPVI 265
Query: 527 LSHCGVSDVIRQPLTELEVAQLSGNLLKSWLKLRDNL 637
++ GVS++ + L + E S +L KS K+R ++
Sbjct: 266 INQNGVSEIQKIKLDDTE----SSSLKKSAEKIRSDI 298
>UniRef50_Q82R06 Cluster: Putative lactate dehydrogenase; n=1;
Streptomyces avermitilis|Rep: Putative lactate
dehydrogenase - Streptomyces avermitilis
Length = 303
Score = 51.2 bits (117), Expect = 3e-05
Identities = 21/39 (53%), Positives = 29/39 (74%)
Frame = +3
Query: 123 GSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSV 239
G G+NLDSAR+R L+ L + T+ HG++IGEHGD +V
Sbjct: 140 GIGSNLDSARYRLTLAHLLDVPATTVHGHVIGEHGDGAV 178
>UniRef50_Q04GC4 Cluster: Enzyme with possible activities of L-2-
hydroxyisocaproate/malate/lactate dehydrogenase; n=2;
Oenococcus oeni|Rep: Enzyme with possible activities of
L-2- hydroxyisocaproate/malate/lactate dehydrogenase -
Oenococcus oeni (strain BAA-331 / PSU-1)
Length = 304
Score = 49.6 bits (113), Expect = 8e-05
Identities = 21/45 (46%), Positives = 30/45 (66%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
IG+GT LDS+R + + +R I S G++IGEHG+S P WS+
Sbjct: 142 IGTGTFLDSSRLKKEIGERFKIDPRSVSGFVIGEHGNSQFPAWSS 186
>UniRef50_Q4A0K7 Cluster: Lactate dehydrogenase; n=1; Staphylococcus
saprophyticus subsp. saprophyticus ATCC 15305|Rep:
Lactate dehydrogenase - Staphylococcus saprophyticus
subsp. saprophyticus (strain ATCC 15305 /DSM 20229)
Length = 310
Score = 49.2 bits (112), Expect = 1e-04
Identities = 18/44 (40%), Positives = 31/44 (70%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IG+GT L+++RF+ +++D I + ++IGEHG ++PVWS
Sbjct: 141 IGTGTALETSRFKTIIADHYQIDPNNVEAFVIGEHGQHAIPVWS 184
>UniRef50_Q38YI2 Cluster: Putative malate dehydrogenase; n=1;
Lactobacillus sakei subsp. sakei 23K|Rep: Putative
malate dehydrogenase - Lactobacillus sakei subsp. sakei
(strain 23K)
Length = 301
Score = 49.2 bits (112), Expect = 1e-04
Identities = 21/53 (39%), Positives = 30/53 (56%)
Frame = +3
Query: 93 LAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
L G +G+GT LD+AR + + L +A S GY++GEHG+S WS
Sbjct: 133 LTGFPKERVLGTGTTLDTARMQVAVGHYLNVAPNSVQGYVLGEHGNSQFVAWS 185
Score = 47.6 bits (108), Expect = 3e-04
Identities = 41/147 (27%), Positives = 62/147 (42%), Gaps = 2/147 (1%)
Frame = +2
Query: 38 ILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYH--VLPXXX 211
IL+ +NP D++T ++G PK RV LG GT A Q ++ V P
Sbjct: 115 ILLNITNPCDVITQYLQALTGFPKERV------LGTGTTLDTARMQVAVGHYLNVAPNSV 168
Query: 212 XXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKGYTS 391
+S + +GV + + T PE + + + A+E++ KGYTS
Sbjct: 169 QGYVLGEHGNSQF-VAWSGVHVG--GQPLATQLSPEQLAQFEVDARQGAWEILSGKGYTS 225
Query: 392 WAIGLSLAQIVRAILTNANSVHAVSTY 472
+ I A AIL N V VS +
Sbjct: 226 YGIANQAAHCAAAILQNTRQVLPVSNF 252
>UniRef50_Q03ZZ4 Cluster: Enzyme with possible activities of L-2-
hydroxyisocaproate/malate/lactate dehydrogenase; n=3;
Lactobacillales|Rep: Enzyme with possible activities of
L-2- hydroxyisocaproate/malate/lactate dehydrogenase -
Leuconostoc mesenteroides subsp. mesenteroides (strain
ATCC 8293 /NCDO 523)
Length = 304
Score = 49.2 bits (112), Expect = 1e-04
Identities = 22/54 (40%), Positives = 29/54 (53%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+ G + G+GT LD+AR + L D L I GY++GEHGDS WS
Sbjct: 132 KATGLPANQVFGTGTYLDTARLKRALGDTLAIDPRGISGYMLGEHGDSQFAAWS 185
Score = 37.1 bits (82), Expect = 0.45
Identities = 41/192 (21%), Positives = 75/192 (39%), Gaps = 2/192 (1%)
Frame = +2
Query: 38 ILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVLPXXXXX 217
+L++ SNPVD++T + K +GLP ++V L + +
Sbjct: 115 VLIVISNPVDVITGIYQKATGLPANQVFGTGTYLDTARLKRALGDTLAIDPRGISGYMLG 174
Query: 218 XXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKGYTSWA 397
++ +N G +L N ++ E + V K YT++A
Sbjct: 175 EHGDSQFAAWSTVNALGKNADELVKLYDI-----NLDKVAEAARVGGFTVFAGKKYTNFA 229
Query: 398 IGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIRQPLTEL 577
I + + + +L+NA VS Y + G ++S P ++ GV+ LT+
Sbjct: 230 IAHAAVSLAKLVLSNARREAIVSHYDERFEG-----YISTPAIIGRDGVTAEFDLQLTDE 284
Query: 578 E--VAQLSGNLL 607
E + Q S N +
Sbjct: 285 EKILLQKSANAI 296
>UniRef50_Q7M9A7 Cluster: Malate dehydrogenase; n=4;
Epsilonproteobacteria|Rep: Malate dehydrogenase -
Wolinella succinogenes
Length = 314
Score = 48.4 bits (110), Expect = 2e-04
Identities = 53/202 (26%), Positives = 90/202 (44%), Gaps = 9/202 (4%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
++ ++ Y +++LV+ SNP+D + Y K SGL +V LG+ + L + A
Sbjct: 99 VLSEVKPYIQESVLVMVSNPLDAMVYTAIKESGLSPLQV------LGMAGI-LDSARMAS 151
Query: 182 YRYHVL---PXXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKELHE 340
+ + L MV + N+AGV +++L +P+ +E+
Sbjct: 152 FIFEKLGYGSDQIVASVMGGHGDDMVPLPRYSNVAGVPITELL-------EPQEIEEIIH 204
Query: 341 NVVKSAYEVIKL--KGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLS 514
+ E++ KG +A S A +V AIL N++ V S L+GE+G D V
Sbjct: 205 RTRNAGAEIVGYLKKGSAYFAPAKSTAIMVEAILKNSHQVFPCSVLLQGEYGYSD-VVGG 263
Query: 515 LPCVLSHCGVSDVIRQPLTELE 580
+P L GV ++I L E
Sbjct: 264 VPVKLGSRGVCEIIELELLHEE 285
>UniRef50_UPI00015BB1FC Cluster: malate dehydrogenase (NAD); n=1;
Ignicoccus hospitalis KIN4/I|Rep: malate dehydrogenase
(NAD) - Ignicoccus hospitalis KIN4/I
Length = 311
Score = 47.6 bits (108), Expect = 3e-04
Identities = 20/47 (42%), Positives = 30/47 (63%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA*T 260
IG+GT+LD+ RFR +S+ L + GY++GEHG+ + WS T
Sbjct: 144 IGTGTSLDTYRFRSAVSELLNEPIAAIDGYVVGEHGEEAFVAWSTVT 190
>UniRef50_A1C5Q5 Cluster: L-lactate dehydrogenase; n=4;
Pezizomycotina|Rep: L-lactate dehydrogenase -
Aspergillus clavatus
Length = 312
Score = 47.6 bits (108), Expect = 3e-04
Identities = 21/39 (53%), Positives = 29/39 (74%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRV 118
IIP + + PDTIL++ SNPVD+LT V ++SGLP +V
Sbjct: 108 IIPAMRPFRPDTILLVVSNPVDLLTTVAQQLSGLPPTQV 146
Score = 44.4 bits (100), Expect = 0.003
Identities = 22/57 (38%), Positives = 31/57 (54%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA*T 260
+L+G T +GSGT L+S R R L++ G+A S Y++G HG WS T
Sbjct: 137 QLSGLPPTQVLGSGTLLESVRLRGLVAKTTGVAPDSVDLYVLGVHGIGETVAWSTAT 193
>UniRef50_Q8I8U4 Cluster: Lactate dehydrogenase; n=3;
Eimeriorina|Rep: Lactate dehydrogenase - Eimeria tenella
Length = 331
Score = 47.2 bits (107), Expect = 4e-04
Identities = 22/50 (44%), Positives = 30/50 (60%)
Frame = +3
Query: 96 AGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 245
AG + G LDSARFR LL+DRLG++ ++G HGD+ VP+
Sbjct: 145 AGLPAARVCGMAGVLDSARFRRLLADRLGVSPRDVQAMVLGVHGDNMVPL 194
>UniRef50_O67581 Cluster: Malate dehydrogenase 2; n=1; Aquifex
aeolicus|Rep: Malate dehydrogenase 2 - Aquifex aeolicus
Length = 334
Score = 47.2 bits (107), Expect = 4e-04
Identities = 56/219 (25%), Positives = 96/219 (43%), Gaps = 13/219 (5%)
Frame = +2
Query: 20 KYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVL 199
+Y+ D+I+++ SNPVD LTY T K++G RV +G+ V + AR++ V
Sbjct: 126 EYAKDSIIIVVSNPVDTLTYATIKLTGFEPRRV------IGMAGV----LDSARFKNFV- 174
Query: 200 PXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDP----ENWKELHENVVKS---A 358
+ + G + + + D P + E+ E + K+
Sbjct: 175 ---KEKIGISNADIRTLVLGTHGDLMVPVTSHSFIGDKPIEEVFSASEIDELIEKTRKGG 231
Query: 359 YEVIKLKGYTS-WAIGLSLAQIVRAILTNANSVHAVSTYLKGE---HGIEDEVFLSLPCV 526
+++ L G ++ +A S+ +V +I+ + V S Y++GE H + V + LP V
Sbjct: 232 AQIVSLMGTSAYYAPAASVVIMVESIINDRKRVMPCSVYVEGEAAKHYEIEGVCIGLPVV 291
Query: 527 LSHCGVSDVIRQPLTELEVAQL--SGNLLKSWLKLRDNL 637
L GV D L+ E +L S LK + L D L
Sbjct: 292 LGKKGVEDFELVNLSGYEKRELLRSAKTLKEMVSLADKL 330
Score = 41.9 bits (94), Expect = 0.016
Identities = 20/54 (37%), Positives = 29/54 (53%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+L G IG LDSARF+ + +++GI+ ++G HGD VPV S
Sbjct: 149 KLTGFEPRRVIGMAGVLDSARFKNFVKEKIGISNADIRTLVLGTHGDLMVPVTS 202
>UniRef50_P14295 Cluster: L-2-hydroxyisocaproate dehydrogenase;
n=15; Lactobacillales|Rep: L-2-hydroxyisocaproate
dehydrogenase - Lactobacillus confusus
Length = 310
Score = 47.2 bits (107), Expect = 4e-04
Identities = 42/169 (24%), Positives = 77/169 (45%)
Frame = +2
Query: 38 ILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVLPXXXXX 217
+LV+ SNPVD++T + ++G P H+V L + AVG+A + + P
Sbjct: 118 VLVVISNPVDVITALFQHVTGFPAHKVIGTGTLLDTARMQ-RAVGEA---FDLDPRSVSG 173
Query: 218 XXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKGYTSWA 397
+S + + VR+ D + + E K + V+ KGYTS+
Sbjct: 174 YNLGEHGNSQF-VAWSTVRVMGQPIVTLADAGDIDLAAIEEEARKGGFTVLNGKGYTSYG 232
Query: 398 IGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGV 544
+ S +I +A++ +A++ VS + + G ++LS P ++ GV
Sbjct: 233 VATSAIRIAKAVMADAHAELVVSN-RRDDMG----MYLSYPAIIGRDGV 276
Score = 41.1 bits (92), Expect = 0.028
Identities = 18/44 (40%), Positives = 26/44 (59%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IG+GT LD+AR + + + + S GY +GEHG+S WS
Sbjct: 145 IGTGTLLDTARMQRAVGEAFDLDPRSVSGYNLGEHGNSQFVAWS 188
>UniRef50_Q7VFV4 Cluster: Malate dehydrogenase; n=1; Helicobacter
hepaticus|Rep: Malate dehydrogenase - Helicobacter
hepaticus
Length = 315
Score = 46.8 bits (106), Expect = 6e-04
Identities = 50/217 (23%), Positives = 93/217 (42%), Gaps = 6/217 (2%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQAR 181
I + + +P ++L++ SNP+D + V + S K RV +G + +
Sbjct: 104 ISSNVARIAPQSLLIVVSNPLDAMCLVAKQWSKFEKERV--------IGMAGILDSARLT 155
Query: 182 YRYHVLPXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDD-DPENWKELHENVVKSA 358
Y V+ S + +R ++ TD P+ +EL +
Sbjct: 156 YESKVMLGDFNKHIQSYVIGSHSDDMLPLLRHCLCEGKVFTDIFTPKMQEELIKETKGGG 215
Query: 359 YEVIKL--KGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLS 532
+++ KG +A + +I+ AI T + S + +GE+GI+D ++L LP L
Sbjct: 216 AKIVNYYQKGSAYFAPASGVIKILEAISTLNEEILVCSVFTEGEYGIKD-IYLGLPIKLG 274
Query: 533 HCGVSDVIRQPLT--ELEVAQLSGNLLKSWLK-LRDN 634
GV ++ PL E E+ +S +K ++ L+DN
Sbjct: 275 KKGVEHIVELPLNQQEQEMLNISTQGIKEQVEILKDN 311
>UniRef50_Q6A6E3 Cluster: L-lactate dehydrogenase; n=1;
Propionibacterium acnes|Rep: L-lactate dehydrogenase -
Propionibacterium acnes
Length = 321
Score = 46.4 bits (105), Expect = 7e-04
Identities = 20/44 (45%), Positives = 30/44 (68%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+G+GT LDSAR +++D LG+ GY+IGEHG S P+++
Sbjct: 151 LGTGTILDSARMCRVVADHLGVDPDYVRGYMIGEHGPSGFPMFT 194
>UniRef50_Q2FPC3 Cluster: Lactate/malate dehydrogenase; n=2;
Methanomicrobiales|Rep: Lactate/malate dehydrogenase -
Methanospirillum hungatei (strain JF-1 / DSM 864)
Length = 290
Score = 46.0 bits (104), Expect = 0.001
Identities = 38/172 (22%), Positives = 78/172 (45%)
Frame = +2
Query: 38 ILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVLPXXXXX 217
I+++ +NP DILTY WK G+ K+R+ +G G + AR++Y +
Sbjct: 107 IIIVVTNPADILTYYLWKSLGILKNRI------IGFG----GQLDSARFQYEL------- 149
Query: 218 XXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKGYTSWA 397
+ + G + ++ G D + ++ + ++ E+IK KG T +A
Sbjct: 150 -SLRSIRDDGIILGEHGEHQVPIFSKTGLDVEIPIRDDILVTLRNASMEIIKGKGATEYA 208
Query: 398 IGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDV 553
+ ++ +I+T+A + S L+GE+ + L +P ++ G+ +
Sbjct: 209 PVYHIWHLIESIITDAKTNLICSAILEGEYDVTG-CSLGVPVIIGREGILSI 259
Score = 43.2 bits (97), Expect = 0.007
Identities = 23/51 (45%), Positives = 30/51 (58%)
Frame = +3
Query: 99 GCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
G L IG G LDSARF+Y LS + + G I+GEHG+ VP++S
Sbjct: 127 GILKNRIIGFGGQLDSARFQYELS----LRSIRDDGIILGEHGEHQVPIFS 173
>UniRef50_Q034P5 Cluster: Enzyme with possible activities of L-2-
hydroxyisocaproate/malate/lactate dehydrogenase; n=1;
Lactobacillus casei ATCC 334|Rep: Enzyme with possible
activities of L-2- hydroxyisocaproate/malate/lactate
dehydrogenase - Lactobacillus casei (strain ATCC 334)
Length = 301
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/44 (43%), Positives = 27/44 (61%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IG+GT+LD+ R R ++D L + GY +GEHG+S WS
Sbjct: 142 IGTGTSLDTYRMRRAVADTLHVNVADVRGYNMGEHGESQFTAWS 185
>UniRef50_Q6LZI3 Cluster: Malate dehydrogenase; n=5;
Methanococcus|Rep: Malate dehydrogenase - Methanococcus
maripaludis
Length = 314
Score = 45.6 bits (103), Expect = 0.001
Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 3/200 (1%)
Frame = +2
Query: 32 DTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVLPXXX 211
DT + + SNPVD++TY SG K++V + L ++ + H L
Sbjct: 115 DTKIFMISNPVDLMTYKALIESGYEKNQVFGLG--THLDSMRFKVAVAKHFEVH-LDDVR 171
Query: 212 XXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKGYTS 391
S + I+ V + +D P ++++ E + E+I LK +
Sbjct: 172 TRIVGEHGDSMVPVISATAVGGIPIKRLPKYEDFP--YEKILERIKGYGQEIINLKNGSE 229
Query: 392 WAIGLSLAQIVRAILTNANSVHAVSTYLKGE-HGIEDEVFLSLPCVLSHCGVSDVIRQPL 568
+ ++ IVR I + + +STY++ E GIE + +P + G+ +VI +
Sbjct: 230 YGPASAIVNIVRCIAHDEKRLLTLSTYIEDEIEGIEGGCCIGVPVKVGKNGIEEVIHIKM 289
Query: 569 --TELEVAQLSGNLLKSWLK 622
E+E + S L+K + +
Sbjct: 290 EDDEIEGFKKSFELVKGYCR 309
Score = 41.9 bits (94), Expect = 0.016
Identities = 20/44 (45%), Positives = 26/44 (59%)
Frame = +3
Query: 123 GSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
G GT+LDS RF+ ++ + I+GEHGDS VPV SA
Sbjct: 145 GLGTHLDSMRFKVAVAKHFEVHLDDVRTRIVGEHGDSMVPVISA 188
>UniRef50_Q979N9 Cluster: Malate dehydrogenase; n=4;
Thermoplasmatales|Rep: Malate dehydrogenase -
Thermoplasma volcanium
Length = 325
Score = 45.2 bits (102), Expect = 0.002
Identities = 18/33 (54%), Positives = 24/33 (72%)
Frame = +2
Query: 20 KYSPDTILVIASNPVDILTYVTWKISGLPKHRV 118
KYSPD+I+V+ SNP DI+ Y KISG+ R+
Sbjct: 114 KYSPDSIIVVVSNPADIMAYALQKISGVDPQRI 146
Score = 42.7 bits (96), Expect = 0.009
Identities = 18/51 (35%), Positives = 30/51 (58%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVP 242
+++G +G G +LDS+RFR L+ L ++ + ++IG HGD VP
Sbjct: 137 KISGVDPQRIMGLGGSLDSSRFRTFLAKELDVSVEDVNAFVIGGHGDDMVP 187
>UniRef50_UPI000023CE12 Cluster: hypothetical protein FG10444.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG10444.1 - Gibberella zeae PH-1
Length = 309
Score = 44.8 bits (101), Expect = 0.002
Identities = 54/204 (26%), Positives = 90/204 (44%), Gaps = 7/204 (3%)
Frame = +2
Query: 23 YSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVLP 202
+ DT+L+I ++PVD+LT + ++SGLP+ +V L T L G R V P
Sbjct: 111 FRADTVLLIVADPVDLLTSLAKQMSGLPESQVFGTG--TALDTYRLR--GMIASRALVSP 166
Query: 203 XXXXXXXXXXXXSSMVCI----NIAGVRLSDLNNQIGTDDDPENWKELHENVVK-SAYEV 367
V + I V + D+ D + E + K + ++
Sbjct: 167 YTVDAFVVGRHGEEQVVVWSSATIGAVPIQDVKMLDSID------RSRIELICKHRSNQI 220
Query: 368 IKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVS 547
I KG + I +A + +++ + + ++ VS Y + EHG LSLP V+ G+
Sbjct: 221 ILGKGSAPFGIASVVANLCCSVILDKHEMYPVS-YFQEEHG----CCLSLPAVIGRKGIL 275
Query: 548 DVIRQPLTELEVA--QLSGNLLKS 613
+ + E E A +LSG LLK+
Sbjct: 276 NSVPLATNENESAAVKLSGKLLKA 299
Score = 43.2 bits (97), Expect = 0.007
Identities = 18/60 (30%), Positives = 35/60 (58%)
Frame = +3
Query: 81 LRGRLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA*T 260
L +++G + G+GT LD+ R R +++ R ++ + +++G HG+ V VWS+ T
Sbjct: 130 LAKQMSGLPESQVFGTGTALDTYRLRGMIASRALVSPYTVDAFVVGRHGEEQVVVWSSAT 189
>UniRef50_Q5FIY9 Cluster: L-LDH; n=6; Lactobacillus|Rep: L-LDH -
Lactobacillus acidophilus
Length = 304
Score = 44.8 bits (101), Expect = 0.002
Identities = 18/51 (35%), Positives = 30/51 (58%)
Frame = +3
Query: 99 GCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
G +G+GT LD+AR + ++ ++LG + G+++GEHG S WS
Sbjct: 135 GLSKNQVLGTGTFLDTARMQRIIGEKLGQDPKNVEGWVLGEHGSSQFIAWS 185
>UniRef50_O52354 Cluster: L-lactate dehydrogenase; n=1; Mycoplasma
gallisepticum|Rep: L-lactate dehydrogenase - Mycoplasma
gallisepticum
Length = 323
Score = 44.4 bits (100), Expect = 0.003
Identities = 16/44 (36%), Positives = 29/44 (65%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
I +G L++ R R ++S+ LG+ + S G+++GEHG ++ WS
Sbjct: 147 ISTGCQLETMRTRKMISEALGVNSDSVEGFVVGEHGSGAIVPWS 190
Score = 44.4 bits (100), Expect = 0.003
Identities = 23/72 (31%), Positives = 40/72 (55%)
Frame = +2
Query: 326 KELHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEV 505
K++ VVK A+E+IK K T + I S++ I RA + N N+V V L ++ + +
Sbjct: 214 KDIFSRVVKEAFEIIKFKKATYFGIAESMSLITRAYIYNLNTVLGVGVQLDDKY-VASGI 272
Query: 506 FLSLPCVLSHCG 541
+ ++P V+ G
Sbjct: 273 YFTVPAVVGKHG 284
>UniRef50_A0RPE9 Cluster: Malate dehydrogenase; n=1; Campylobacter
fetus subsp. fetus 82-40|Rep: Malate dehydrogenase -
Campylobacter fetus subsp. fetus (strain 82-40)
Length = 306
Score = 43.6 bits (98), Expect = 0.005
Identities = 18/40 (45%), Positives = 24/40 (60%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSV 239
IG LDSARFRY +S +LG+ C G +G H +S +
Sbjct: 140 IGMAGELDSARFRYYMSQKLGLNVAQCFGKCVGMHNNSMI 179
Score = 41.9 bits (94), Expect = 0.016
Identities = 14/33 (42%), Positives = 26/33 (78%)
Frame = +2
Query: 20 KYSPDTILVIASNPVDILTYVTWKISGLPKHRV 118
K++P +I+++ +NP+DI+ YV +K SG +H+V
Sbjct: 107 KFAPKSIIIVVTNPLDIMVYVAFKESGFARHKV 139
>UniRef50_A7U552 Cluster: Mitochondrial malate-dehydrogenase; n=2;
Toxoplasma gondii|Rep: Mitochondrial
malate-dehydrogenase - Toxoplasma gondii
Length = 470
Score = 43.6 bits (98), Expect = 0.005
Identities = 38/189 (20%), Positives = 78/189 (41%), Gaps = 2/189 (1%)
Frame = +2
Query: 20 KYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVL 199
+Y P+ ++ +NP+D++ Y+ + GLP H+V + L + + +
Sbjct: 263 QYCPNAFVICITNPLDVMVYILREKCGLPPHKVCGMAGVLDSARLRTFLSERLNVSVDDI 322
Query: 200 PXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKL- 376
+ G+ L +L ++G E ++ + E++ L
Sbjct: 323 HALVMGGHGDTMVPLPRFTTVGGIPLPEL-VKMGMISQQE-VDDIVQRTRNGGGEIVSLL 380
Query: 377 -KGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDV 553
G +A + + A L + V + YL GE+G++D +++ +PCV+ GV +
Sbjct: 381 KTGSAFFAPAAAGVLMAEAYLKDRKRVLPCAAYLNGEYGVKD-MYVGVPCVIGAGGVEKI 439
Query: 554 IRQPLTELE 580
+ LT E
Sbjct: 440 VELDLTPEE 448
Score = 41.9 bits (94), Expect = 0.016
Identities = 17/36 (47%), Positives = 24/36 (66%)
Frame = +3
Query: 138 LDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 245
LDSAR R LS+RL ++ H ++G HGD+ VP+
Sbjct: 302 LDSARLRTFLSERLNVSVDDIHALVMGGHGDTMVPL 337
>UniRef50_P11386 Cluster: Malate dehydrogenase; n=6;
Sulfolobaceae|Rep: Malate dehydrogenase - Sulfolobus
acidocaldarius
Length = 306
Score = 43.6 bits (98), Expect = 0.005
Identities = 30/107 (28%), Positives = 54/107 (50%), Gaps = 1/107 (0%)
Frame = +2
Query: 320 NWKELHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIED 499
N E+ + V K A E+I++ G T+W G + +++R++ N V +V+ H ED
Sbjct: 197 NKAEVEDYVKKIAAEIIRVLGGTTWGPGADIEEVIRSVALNEGKVMSVAF----PHKYED 252
Query: 500 EVF-LSLPCVLSHCGVSDVIRQPLTELEVAQLSGNLLKSWLKLRDNL 637
E+ +S P V+ V + L E + A+LS + + + + NL
Sbjct: 253 EIIHISEPVVVGRT-VGPALTSALDENDKARLSQAIKEVYNVYKSNL 298
Score = 37.9 bits (84), Expect = 0.26
Identities = 15/47 (31%), Positives = 28/47 (59%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA*T 260
I +G +++ R R ++ +L I GY+ GEHG++++ +WS T
Sbjct: 138 ISTGNQVETMRMRSYIAKKLNIPAYEVGGYVGGEHGEAAMVLWSTVT 184
>UniRef50_A5Z9B1 Cluster: Putative uncharacterized protein; n=1;
Eubacterium ventriosum ATCC 27560|Rep: Putative
uncharacterized protein - Eubacterium ventriosum ATCC
27560
Length = 312
Score = 43.2 bits (97), Expect = 0.007
Identities = 21/54 (38%), Positives = 31/54 (57%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
+ G +GT+LD+AR R ++D IA S G+ +GEHGDSS+ +S
Sbjct: 133 KATGLPKNRVFSTGTSLDTARMRRTVADLCNIAPQSVIGFAMGEHGDSSMVPFS 186
>UniRef50_Q5M0L6 Cluster: L-2-hydroxyisocaproate dehydrogenase; n=3;
Streptococcus thermophilus|Rep: L-2-hydroxyisocaproate
dehydrogenase - Streptococcus thermophilus (strain CNRZ
1066)
Length = 316
Score = 42.7 bits (96), Expect = 0.009
Identities = 48/188 (25%), Positives = 77/188 (40%)
Frame = +2
Query: 38 ILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVLPXXXXX 217
IL++ SNPVD +T + + +G PK RV L + AVG+ V P
Sbjct: 117 ILLVISNPVDAVTALYQEFTGWPKERVIGTGTLLDTARMKT-AVGEV---LEVNPKSVSG 172
Query: 218 XXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKGYTSWA 397
+S A ++ I E + L +K ++V KGYTS+
Sbjct: 173 YNLGEHGNSQFT---AWSQVKVKGQDITALTSEEERQNLFRASMKGGHKVFYGKGYTSYG 229
Query: 398 IGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIRQPLTEL 577
I + ++V IL++A VS+Y + + +L P +L GV + L+
Sbjct: 230 IASAALRLVAIILSDAQEEVTVSSYQE-----IYQTYLGYPVILGRQGVEAPVHLTLSAE 284
Query: 578 EVAQLSGN 601
E L G+
Sbjct: 285 EKHLLQGS 292
Score = 42.7 bits (96), Expect = 0.009
Identities = 19/44 (43%), Positives = 27/44 (61%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IG+GT LD+AR + + + L + S GY +GEHG+S WS
Sbjct: 144 IGTGTLLDTARMKTAVGEVLEVNPKSVSGYNLGEHGNSQFTAWS 187
>UniRef50_Q0P989 Cluster: L-lactate dehydrogenase; n=10;
Campylobacter|Rep: L-lactate dehydrogenase -
Campylobacter jejuni
Length = 308
Score = 42.3 bits (95), Expect = 0.012
Identities = 20/37 (54%), Positives = 25/37 (67%)
Frame = +3
Query: 123 GSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDS 233
GSGTNLDS+R + LL+ L I + +IGEHGDS
Sbjct: 143 GSGTNLDSSRLKKLLAKDLNINSKDIFACMIGEHGDS 179
>UniRef50_Q88ZG9 Cluster: L-2-hydroxyisocaproate dehydrogenase; n=2;
Lactobacillus plantarum|Rep: L-2-hydroxyisocaproate
dehydrogenase - Lactobacillus plantarum
Length = 319
Score = 41.5 bits (93), Expect = 0.021
Identities = 18/54 (33%), Positives = 28/54 (51%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
R G G+GT LD+AR + ++++ + GY+ GEHG+S WS
Sbjct: 133 RATGLSRQQVFGTGTFLDTARMQKVVAEAFDCDPKNISGYVYGEHGESQFSAWS 186
>UniRef50_A7I2F1 Cluster: Malate dehydrogenase; n=1; Campylobacter
hominis ATCC BAA-381|Rep: Malate dehydrogenase -
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 /
NCTC 13146 /CH001A)
Length = 297
Score = 41.1 bits (92), Expect = 0.028
Identities = 34/146 (23%), Positives = 62/146 (42%), Gaps = 1/146 (0%)
Frame = +2
Query: 20 KYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVL 199
KY+P+ I+++ +NPVD L +V +K SG K ++ + AR RY +
Sbjct: 108 KYAPEAIIILITNPVDTLAFVAYKASGFKKEKI----------IAMAGELDSARLRYEI- 156
Query: 200 PXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLK 379
S + N L D + G P+N + EN + S ++ L+
Sbjct: 157 AKSENVNVTDIKASVVGAHNDEMQILEDEIYKFGKKFKPQNLSLIKENTINSGSKITALQ 216
Query: 380 GYTS-WAIGLSLAQIVRAILTNANSV 454
+S +A +++ AI+ + N +
Sbjct: 217 KTSSFFAPAACSVKMIDAIINDKNEI 242
>UniRef50_Q5CYZ2 Cluster: Lactate dehydrogenase, adjacent gene
encodes predicted malate dehydrogenase; n=8;
Cryptosporidium|Rep: Lactate dehydrogenase, adjacent
gene encodes predicted malate dehydrogenase -
Cryptosporidium parvum Iowa II
Length = 337
Score = 41.1 bits (92), Expect = 0.028
Identities = 42/208 (20%), Positives = 83/208 (39%), Gaps = 3/208 (1%)
Frame = +2
Query: 20 KYSPDTILVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVL 199
KY P+ ++ +NP+D++ K+SGLP ++V + L +
Sbjct: 126 KYCPNAFVICITNPLDVMVSHFQKVSGLPHNKVCGMAGVLDSSRFRTFIAQHFGVNASDV 185
Query: 200 PXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDDDPENWKELHENVV-KSAYEVIKL 376
+++ GV LS Q + + H + K + +K
Sbjct: 186 SANVIGGHGDGMVPVTSSVSVGGVPLSSFIKQGLITQEQIDEIVCHTRIAWKEVADNLK- 244
Query: 377 KGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVI 556
G +A + ++ A L + +V S + +G++ +++ +P ++ GV D++
Sbjct: 245 TGTAYFAPAAAAVKMAEAYLKDKKAVVPCSAFCSNHYGVKG-IYMGVPTIIGKNGVEDIL 303
Query: 557 RQPLTELEVAQL--SGNLLKSWLKLRDN 634
LT LE L S N + + K+ DN
Sbjct: 304 ELDLTPLEQKLLGESINEVNTISKVLDN 331
Score = 38.7 bits (86), Expect = 0.15
Identities = 18/55 (32%), Positives = 28/55 (50%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
+++G G LDS+RFR ++ G+ + +IG HGD VPV S+
Sbjct: 149 KVSGLPHNKVCGMAGVLDSSRFRTFIAQHFGVNASDVSANVIGGHGDGMVPVTSS 203
>UniRef50_Q8Y860 Cluster: Lmo1057 protein; n=11; Listeria|Rep:
Lmo1057 protein - Listeria monocytogenes
Length = 317
Score = 40.7 bits (91), Expect = 0.036
Identities = 18/54 (33%), Positives = 31/54 (57%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
R +G + I GT L ++ F+ ++ I+ + HGYIIG++ + +PVWS
Sbjct: 126 RFSGLSANQIITLGTMLATSYFQVEIAKLFKISPKNVHGYIIGDNAEDVIPVWS 179
Score = 39.1 bits (87), Expect = 0.11
Identities = 22/74 (29%), Positives = 40/74 (54%)
Frame = +2
Query: 410 LAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIRQPLTELEVAQ 589
LA++ IL + V V +K +G+E+ VF+S+P V+ GV +++ L++ E +
Sbjct: 235 LAELTEVILRDEARVITVGVEVKEAYGLENPVFISVPAVIGAEGVRELLELNLSDDEQKE 294
Query: 590 LSGNLLKSWLKLRD 631
L K+ KL +
Sbjct: 295 LKQIAAKTTEKLEE 308
>UniRef50_Q7MTK2 Cluster: Malate dehydrogenase; n=4;
Bacteroidales|Rep: Malate dehydrogenase - Porphyromonas
gingivalis (Bacteroides gingivalis)
Length = 334
Score = 39.1 bits (87), Expect = 0.11
Identities = 37/126 (29%), Positives = 52/126 (41%), Gaps = 2/126 (1%)
Frame = +2
Query: 23 YSPDTI-LVIASNPVDILTYVTWKISGLPKHRVHRVRH*LGLGTVPLPAVGQARYRYHVL 199
Y PD ++I NP DI VT SGL +V + GL + L + +
Sbjct: 113 YCPDCKHVIIIFNPADITGLVTLIYSGLKPSQVTTLA---GLDSTRLQSELAKHFGIKQS 169
Query: 200 PXXXXXXXXXXXXSSMVCINIAGVRLSDLNNQIGTDD-DPENWKELHENVVKSAYEVIKL 376
V + A V + L + IGTD E W EL + VVK +IKL
Sbjct: 170 LVTNTRTYGGHGEQMAVFASTAKVNGTPLTDLIGTDKLTNEQWAELKQRVVKGGANIIKL 229
Query: 377 KGYTSW 394
+G +S+
Sbjct: 230 RGRSSF 235
>UniRef50_Q5LXE1 Cluster: Malate dehydrogenase; n=115; cellular
organisms|Rep: Malate dehydrogenase - Silicibacter
pomeroyi
Length = 320
Score = 39.1 bits (87), Expect = 0.11
Identities = 16/51 (31%), Positives = 28/51 (54%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVP 242
+ +G + G LDSARFR+ L++ ++ +++G HGD+ VP
Sbjct: 132 QFSGLPANKVCGMAGVLDSARFRHFLAEEFNVSMKDVTAFVLGGHGDTMVP 182
>UniRef50_Q01VS4 Cluster: Methyltransferase type 11; n=1; Solibacter
usitatus Ellin6076|Rep: Methyltransferase type 11 -
Solibacter usitatus (strain Ellin6076)
Length = 246
Score = 38.7 bits (86), Expect = 0.15
Identities = 31/102 (30%), Positives = 54/102 (52%), Gaps = 9/102 (8%)
Frame = -2
Query: 496 FDAVLALEISRDRMNAVSVREYSPHDLSQRQSD-SPGSVSLQFDDFVS--TFHDI----- 341
FD+VLA++IS + M A++ + S ++ R +D S +FD VS TFH I
Sbjct: 78 FDSVLAIDIS-EPMLAIARAKRSAPNIEYRLADASTAEFEGEFDAVVSHTTFHHIADVAG 136
Query: 340 -LVKLLPVLRIVVGSDLIVEITEAYSRYVYADHTGTLLSPCS 218
+ + P+L G LI+++ + + R+ Y + G +L C+
Sbjct: 137 TITRFKPML-ARQGRFLIIDLVDRWPRFRYKPYAGLILGACA 177
>UniRef50_A3CTN0 Cluster: Lactate/malate dehydrogenase; n=1;
Methanoculleus marisnigri JR1|Rep: Lactate/malate
dehydrogenase - Methanoculleus marisnigri (strain ATCC
35101 / DSM 1498 / JR1)
Length = 288
Score = 37.9 bits (84), Expect = 0.26
Identities = 21/44 (47%), Positives = 29/44 (65%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
IG G+ LDSARF L + +GI + +++GEHGD VPV+S
Sbjct: 134 IGFGSQLDSARFAGFLRE-VGIPGPA---WVLGEHGDRQVPVFS 173
Score = 35.9 bits (79), Expect = 1.0
Identities = 28/110 (25%), Positives = 51/110 (46%)
Frame = +2
Query: 266 GVRLSDLNNQIGTDDDPENWKELHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNA 445
G R + ++ G+D D + + + ++ EVI+ KG T + +A ++RAIL +
Sbjct: 165 GDRQVPVFSKTGSDLDTGEREAILSRMRGASMEVIRGKGGTVFGPAYHIAMLIRAILHDR 224
Query: 446 NSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIRQPLTELEVAQLS 595
V S L GE G+ L +P + G+ + L E A+++
Sbjct: 225 REVLPCSCVLDGEFGLSG-CSLGVPARIGREGILGIEEWELDTWESAKMA 273
>UniRef50_Q8YXL9 Cluster: All1193 protein; n=2; Nostocaceae|Rep:
All1193 protein - Anabaena sp. (strain PCC 7120)
Length = 167
Score = 37.5 bits (83), Expect = 0.34
Identities = 20/69 (28%), Positives = 39/69 (56%)
Frame = -2
Query: 493 DAVLALEISRDRMNAVSVREYSPHDLSQRQSDSPGSVSLQFDDFVSTFHDILVKLLPVLR 314
D +++L +R N V +R+ S +S + S ++S+ FD+ V++ + V+L V R
Sbjct: 72 DLMISLPSQMERFNGVRIRDQSGKAISAKTEISKDNLSITFDEPVTSGASVEVELTGVRR 131
Query: 313 IVVGSDLIV 287
VG D+++
Sbjct: 132 NGVGQDVLL 140
>UniRef50_Q0PQR8 Cluster: Malate dehydrogenase NAD-dependent; n=1;
Endoriftia persephone 'Hot96_1+Hot96_2'|Rep: Malate
dehydrogenase NAD-dependent - Endoriftia persephone
'Hot96_1+Hot96_2'
Length = 170
Score = 37.1 bits (82), Expect = 0.45
Identities = 12/33 (36%), Positives = 23/33 (69%)
Frame = +2
Query: 20 KYSPDTILVIASNPVDILTYVTWKISGLPKHRV 118
+++PD +++ +NP+D + Y K+SGLP R+
Sbjct: 35 QHAPDAFVILTTNPLDSIVYAFHKLSGLPAERI 67
Score = 35.1 bits (77), Expect = 1.8
Identities = 16/52 (30%), Positives = 28/52 (53%)
Frame = +3
Query: 90 RLAGCLSTAFIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 245
+L+G + IG LD+ARFR ++ G++ ++G HG + +PV
Sbjct: 58 KLSGLPAERIIGMAGALDTARFRTYIAMETGLSVKDVSCLVMGGHGPTMIPV 109
>UniRef50_A2QJT7 Cluster: Catalytic activity: precursor; n=1;
Aspergillus niger|Rep: Catalytic activity: precursor -
Aspergillus niger
Length = 307
Score = 37.1 bits (82), Expect = 0.45
Identities = 14/39 (35%), Positives = 28/39 (71%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRV 118
I+ ++ ++P+ I+++ +NPVD LT + I+GLP+ +V
Sbjct: 101 ILNEMRPFNPNAIILVVANPVDTLTTLAQDIAGLPRKQV 139
>UniRef50_A4BB89 Cluster: Lactate dehydrogenase; n=2;
Gammaproteobacteria|Rep: Lactate dehydrogenase -
Reinekea sp. MED297
Length = 319
Score = 36.7 bits (81), Expect = 0.59
Identities = 15/43 (34%), Positives = 25/43 (58%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVW 248
I +G +D+AR L+S+++ + + GYI+GEHG W
Sbjct: 141 ISAGCIIDTARLMKLVSEKVDVDPKNVSGYILGEHGSHCFMPW 183
>UniRef50_A5IYS9 Cluster: L-lactate dehydrogenase; n=2;
Mycoplasma|Rep: L-lactate dehydrogenase - Mycoplasma
agalactiae
Length = 323
Score = 36.3 bits (80), Expect = 0.78
Identities = 13/44 (29%), Positives = 27/44 (61%)
Frame = +3
Query: 120 IGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWS 251
I +GTNL++ R + +L+ + + + ++GEHG +++ WS
Sbjct: 143 ISAGTNLETGRLKKMLAAKFNTSPDAIRASVLGEHGATAMIAWS 186
>UniRef50_Q8IE66 Cluster: Oxidoreductase, putative; n=6;
Plasmodium|Rep: Oxidoreductase, putative - Plasmodium
falciparum (isolate 3D7)
Length = 334
Score = 36.3 bits (80), Expect = 0.78
Identities = 15/36 (41%), Positives = 23/36 (63%)
Frame = +3
Query: 138 LDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 245
L SAR R+ L+++L + G++IG HGD VP+
Sbjct: 157 LHSARLRHNLAEKLRVNPGDVQGFVIGAHGDKMVPL 192
>UniRef50_Q5B0T8 Cluster: Putative uncharacterized protein; n=1;
Emericella nidulans|Rep: Putative uncharacterized
protein - Emericella nidulans (Aspergillus nidulans)
Length = 237
Score = 36.3 bits (80), Expect = 0.78
Identities = 15/39 (38%), Positives = 27/39 (69%)
Frame = +2
Query: 2 IIPQLIKYSPDTILVIASNPVDILTYVTWKISGLPKHRV 118
II ++ + DT+L+I +NPVD++T + ++S LP +V
Sbjct: 107 IINEMKPFRSDTVLLIVANPVDLMTSLAKELSNLPSAQV 145
>UniRef50_Q6YPG1 Cluster: Putative uncharacterized protein
OJA1212_C06.24; n=1; Oryza sativa (japonica
cultivar-group)|Rep: Putative uncharacterized protein
OJA1212_C06.24 - Oryza sativa subsp. japonica (Rice)
Length = 255
Score = 35.9 bits (79), Expect = 1.0
Identities = 19/39 (48%), Positives = 22/39 (56%)
Frame = -3
Query: 117 TRCLGSPLIFHVTYVRISTGLLAITNIVSGLYFISCGII 1
TR G+P FH TYV STGL I++ SG S G I
Sbjct: 65 TRLAGNPDSFHATYVSTSTGLETISSSASGECSASAGTI 103
>UniRef50_A1CF32 Cluster: Forkhead domain protein; n=3;
Trichocomaceae|Rep: Forkhead domain protein -
Aspergillus clavatus
Length = 494
Score = 34.7 bits (76), Expect = 2.4
Identities = 19/39 (48%), Positives = 22/39 (56%)
Frame = +1
Query: 541 SL*RHPPASNRT*SGTAFGKSAKVMAKVAGQPLILTRNA 657
SL PPA R SG GK+ K+ AK GQ LI+T A
Sbjct: 326 SLGSDPPAPQRQRSGAKGGKATKITAKYRGQMLIVTGQA 364
>UniRef50_Q182W1 Cluster: Putative exported protein precursor; n=2;
Clostridium difficile|Rep: Putative exported protein
precursor - Clostridium difficile (strain 630)
Length = 651
Score = 34.3 bits (75), Expect = 3.2
Identities = 24/75 (32%), Positives = 38/75 (50%), Gaps = 3/75 (4%)
Frame = +2
Query: 284 LNNQIGTDDDPENWKELHENVVKSAYEVI-KLKGYTSWAIGLSLAQIVRAILTN--ANSV 454
+NN I TD +E + +KS+YE + K+K AIG+ +R + + N
Sbjct: 121 INNIIATDGTALYVEEGGDLHIKSSYESVEKIKANGKDAIGIYTENDIRILNKDIEVNGE 180
Query: 455 HAVSTYLKGEHGIED 499
HA+ Y KG+ IE+
Sbjct: 181 HAIGVYSKGDVEIEE 195
>UniRef50_A2SR33 Cluster: Lactate/malate dehydrogenase; n=1;
Methanocorpusculum labreanum Z|Rep: Lactate/malate
dehydrogenase - Methanocorpusculum labreanum (strain
ATCC 43576 / DSM 4855 / Z)
Length = 283
Score = 34.3 bits (75), Expect = 3.2
Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 1/52 (1%)
Frame = +3
Query: 102 CLSTA-FIGSGTNLDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPVWSA 254
CL + +G G LDS RF +L +GI G ++GEHG+ VP++S+
Sbjct: 126 CLDESQVVGFGGLLDSRRFTVVLRS-IGI---EAEGQVLGEHGEHQVPLFSS 173
>UniRef50_A2A0F6 Cluster: Transcriptional regulator, XRE family;
n=1; Microscilla marina ATCC 23134|Rep: Transcriptional
regulator, XRE family - Microscilla marina ATCC 23134
Length = 135
Score = 33.9 bits (74), Expect = 4.2
Identities = 19/73 (26%), Positives = 37/73 (50%)
Frame = -2
Query: 478 LEISRDRMNAVSVREYSPHDLSQRQSDSPGSVSLQFDDFVSTFHDILVKLLPVLRIVVGS 299
L I+ + + ++ DL+++ VS ++S H++ VK + L +V+G
Sbjct: 25 LAITEQIFEILESKGWTQKDLAKKMGKHESEVS----KWLSGLHNLTVKTITKLEVVLGE 80
Query: 298 DLIVEITEAYSRY 260
D+I+ TEA +Y
Sbjct: 81 DIILTPTEAQKQY 93
>UniRef50_Q6VVP7 Cluster: Malate dehydrogenase; n=6; Plasmodium|Rep:
Malate dehydrogenase - Plasmodium falciparum
Length = 313
Score = 33.5 bits (73), Expect = 5.5
Identities = 13/36 (36%), Positives = 24/36 (66%)
Frame = +3
Query: 138 LDSARFRYLLSDRLGIATTSCHGYIIGEHGDSSVPV 245
LD++R+ L++D+L ++ + I+G HGD VP+
Sbjct: 146 LDTSRYCSLIADKLKVSAEDVNAVILGGHGDLMVPL 181
>UniRef50_Q2LTZ4 Cluster: Hypothetical sex pilus assembly and
synthesis protein; n=1; Syntrophus aciditrophicus
SB|Rep: Hypothetical sex pilus assembly and synthesis
protein - Syntrophus aciditrophicus (strain SB)
Length = 194
Score = 33.1 bits (72), Expect = 7.3
Identities = 19/69 (27%), Positives = 38/69 (55%), Gaps = 2/69 (2%)
Frame = -2
Query: 550 VRDSTVTQHARQRQKYFVFDAVLA--LEISRDRMNAVSVREYSPHDLSQRQSDSPGSVSL 377
+ ++ +T A Q+ + VL +EI+ DR++ V+ +S + + S SPG+V
Sbjct: 32 IANAVMTYRALNYQRTIIVPPVLKSRIEITGDRVSEEYVKAFSRYIAALSFSYSPGTVKP 91
Query: 376 QFDDFVSTF 350
QFD+ ++ +
Sbjct: 92 QFDELLALY 100
>UniRef50_Q097V0 Cluster: Putative uncharacterized protein; n=1;
Stigmatella aurantiaca DW4/3-1|Rep: Putative
uncharacterized protein - Stigmatella aurantiaca DW4/3-1
Length = 320
Score = 33.1 bits (72), Expect = 7.3
Identities = 28/81 (34%), Positives = 40/81 (49%)
Frame = +2
Query: 299 GTDDDPENWKELHENVVKSAYEVIKLKGYTSWAIGLSLAQIVRAILTNANSVHAVSTYLK 478
G D PE+ + L+E VV + E + L T WA L A + RA L + + V+T+ +
Sbjct: 4 GNDTWPESLQALYEQVVAAPREAV-LSARTQWAEQLG-AWVQRASL-DEREMARVATWAR 60
Query: 479 GEHGIEDEVFLSLPCVLSHCG 541
E G L +LSHCG
Sbjct: 61 LEAGPRSAG--ELVFLLSHCG 79
>UniRef50_A2SKC7 Cluster: Flagellin-related hook-associated protein;
n=1; Methylibium petroleiphilum PM1|Rep:
Flagellin-related hook-associated protein - Methylibium
petroleiphilum (strain PM1)
Length = 398
Score = 32.7 bits (71), Expect = 9.7
Identities = 22/75 (29%), Positives = 33/75 (44%)
Frame = +2
Query: 398 IGLSLAQIVRAILTNANSVHAVSTYLKGEHGIEDEVFLSLPCVLSHCGVSDVIRQPLTEL 577
+ +SL Q+ +LT ANS +YL G + F+ P + GVS P TE
Sbjct: 110 LAISLRQMRAELLTIANSPDGAGSYLFAGQGASNPPFVDTPTGVQFRGVSGETGAPSTEP 169
Query: 578 EVAQLSGNLLKSWLK 622
+ G +WL+
Sbjct: 170 LPLTMDGR--STWLQ 182
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 721,565,543
Number of Sequences: 1657284
Number of extensions: 14147169
Number of successful extensions: 39786
Number of sequences better than 10.0: 142
Number of HSP's better than 10.0 without gapping: 38314
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 39753
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 60088620670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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