Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= wdS30485
(628 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9NXA8 Cluster: NAD-dependent deacetylase sirtuin-5; n=... 203 2e-51
UniRef50_UPI0000D578DC Cluster: PREDICTED: similar to sirtuin 5 ... 159 7e-38
UniRef50_A7RMK8 Cluster: Predicted protein; n=5; Eumetazoa|Rep: ... 149 4e-35
UniRef50_Q8ZT00 Cluster: NAD-dependent deacetylase 2; n=2; cellu... 120 2e-26
UniRef50_Q8U1Q1 Cluster: NAD-dependent deacetylase; n=19; cellul... 114 1e-24
UniRef50_Q9CBW6 Cluster: NAD-dependent deacetylase; n=14; Mycoba... 109 7e-23
UniRef50_Q0LFI4 Cluster: Silent information regulator protein Si... 105 9e-22
UniRef50_Q3E2I1 Cluster: Silent information regulator protein Si... 104 2e-21
UniRef50_Q8Y015 Cluster: NAD-dependent deacetylase; n=11; Bacter... 101 1e-20
UniRef50_A5WD15 Cluster: Silent information regulator protein Si... 98 2e-19
UniRef50_A1FG80 Cluster: Silent information regulator protein Si... 97 4e-19
UniRef50_A7DQD6 Cluster: Silent information regulator protein Si... 95 2e-18
UniRef50_Q1D737 Cluster: NAD-dependent deacetylase; n=1; Myxococ... 94 3e-18
UniRef50_Q8FRV5 Cluster: NAD-dependent deacetylase 2; n=9; Coryn... 94 3e-18
UniRef50_Q0LN22 Cluster: Silent information regulator protein Si... 93 5e-18
UniRef50_Q9RYD4 Cluster: NAD-dependent deacetylase; n=4; Deinoco... 93 7e-18
UniRef50_Q0LIC7 Cluster: Silent information regulator protein Si... 92 9e-18
UniRef50_A5K7T7 Cluster: NAD-dependent deacetylase, putative; n=... 92 1e-17
UniRef50_Q607X6 Cluster: NAD-dependent deacetylase; n=1; Methylo... 92 1e-17
UniRef50_Q8F3Z6 Cluster: NAD-dependent deacetylase; n=4; Leptosp... 89 6e-17
UniRef50_A0LG97 Cluster: Silent information regulator protein Si... 89 1e-16
UniRef50_Q8ZFR1 Cluster: NAD-dependent deacetylase; n=149; cellu... 88 2e-16
UniRef50_Q6C8C7 Cluster: Similar to DEHA0C01507g Debaryomyces ha... 87 2e-16
UniRef50_Q21KQ1 Cluster: Silent information regulator protein Si... 85 1e-15
UniRef50_Q4APN6 Cluster: Silent information regulator protein Si... 85 2e-15
UniRef50_Q2YZT2 Cluster: Putative uncharacterized protein; n=1; ... 85 2e-15
UniRef50_A4J646 Cluster: Silent information regulator protein Si... 85 2e-15
UniRef50_A5USR3 Cluster: Silent information regulator protein Si... 84 2e-15
UniRef50_A7SK95 Cluster: Predicted protein; n=1; Nematostella ve... 82 9e-15
UniRef50_Q9WYW0 Cluster: NAD-dependent deacetylase; n=4; Thermot... 82 1e-14
UniRef50_Q9I4L0 Cluster: NAD-dependent deacetylase 1; n=10; Bact... 81 2e-14
UniRef50_A7B9E8 Cluster: Putative uncharacterized protein; n=1; ... 81 2e-14
UniRef50_A6DC77 Cluster: Silent information regulator protein Si... 81 2e-14
UniRef50_Q88BY5 Cluster: NAD-dependent deacetylase; n=9; Bacteri... 81 3e-14
UniRef50_A1I9S7 Cluster: NAD-dependent deacetylase; n=1; Candida... 80 4e-14
UniRef50_Q5YR82 Cluster: Putative Sir2 family regulator; n=1; No... 79 7e-14
UniRef50_Q67KQ0 Cluster: NAD-dependent deacetylase; n=1; Symbiob... 79 9e-14
UniRef50_UPI000049979A Cluster: Sir2 family transcriptional regu... 79 1e-13
UniRef50_Q2LSF2 Cluster: Sir2 family of NAD+-dependent deacetyla... 78 2e-13
UniRef50_A6P1S7 Cluster: Putative uncharacterized protein; n=2; ... 78 2e-13
UniRef50_Q974M6 Cluster: NAD-dependent deacetylase; n=8; Thermop... 78 2e-13
UniRef50_Q8ZU41 Cluster: NAD-dependent deacetylase 1; n=3; Pyrob... 77 3e-13
UniRef50_UPI000049971A Cluster: Sir2 family transcriptional regu... 77 3e-13
UniRef50_Q6BVM7 Cluster: Similar to CA4170|IPF7784 Candida albic... 77 3e-13
UniRef50_Q97MB4 Cluster: NAD-dependent deacetylase; n=7; Bacteri... 76 8e-13
UniRef50_Q89EA6 Cluster: NAD-dependent deacetylase 2; n=9; Prote... 76 8e-13
UniRef50_UPI0000519F58 Cluster: PREDICTED: similar to Sirt4 CG31... 75 1e-12
UniRef50_A1HU63 Cluster: Silent information regulator protein Si... 75 1e-12
UniRef50_Q5L014 Cluster: NAD-dependent deacetylase 1; n=7; Bacil... 75 1e-12
UniRef50_A7H7B6 Cluster: Silent information regulator protein Si... 75 2e-12
UniRef50_A1ZZG3 Cluster: NAD-dependent deacetylase; n=35; Bacter... 75 2e-12
UniRef50_A0NQ49 Cluster: Silent information regulator protein Si... 75 2e-12
UniRef50_Q046W9 Cluster: NAD-dependent protein deacetylase, SIR2... 74 2e-12
UniRef50_UPI00006CB0CC Cluster: transcriptional regulator, Sir2 ... 74 3e-12
UniRef50_Q73KE1 Cluster: NAD-dependent deacetylase; n=1; Trepone... 74 3e-12
UniRef50_A1HLU5 Cluster: Silent information regulator protein Si... 73 4e-12
UniRef50_A6PTK3 Cluster: Silent information regulator protein Si... 73 6e-12
UniRef50_Q7WLE5 Cluster: NAD-dependent deacetylase; n=47; Bacter... 73 7e-12
UniRef50_UPI00015B4FA0 Cluster: PREDICTED: similar to chromatin ... 72 1e-11
UniRef50_A1ZHW6 Cluster: NAD-dependent deacetylase; n=2; Microsc... 72 1e-11
UniRef50_A6FYM4 Cluster: Sir2 family protein; n=1; Plesiocystis ... 71 2e-11
UniRef50_A4M603 Cluster: Silent information regulator protein Si... 71 2e-11
UniRef50_Q5V4Q5 Cluster: NAD-dependent deacetylase; n=2; Halobac... 71 2e-11
UniRef50_A3JEV2 Cluster: NAD-dependent deacetylase; n=2; Marinob... 71 2e-11
UniRef50_Q8A3H9 Cluster: NAD-dependent deacetylase; n=3; Bactero... 71 2e-11
UniRef50_Q5P3W1 Cluster: NAD-dependent deacetylase 2; n=4; Prote... 71 3e-11
UniRef50_A6LP94 Cluster: Silent information regulator protein Si... 71 3e-11
UniRef50_Q1YSP9 Cluster: NAD-dependent deacetylase; n=1; gamma p... 70 5e-11
UniRef50_Q81NT6 Cluster: NAD-dependent deacetylase; n=11; Bacill... 70 5e-11
UniRef50_Q8CJM9 Cluster: NAD-dependent deacetylase 2; n=3; Actin... 70 5e-11
UniRef50_A2QWZ2 Cluster: Function: human SIRT5 belongs to the Si... 69 7e-11
UniRef50_Q899G3 Cluster: NAD-dependent deacetylase; n=19; cellul... 69 7e-11
UniRef50_Q12Y78 Cluster: Silent information regulator protein Si... 69 9e-11
UniRef50_A7HL19 Cluster: Silent information regulator protein Si... 69 1e-10
UniRef50_Q8CNF4 Cluster: NAD-dependent deacetylase; n=17; Staphy... 69 1e-10
UniRef50_A5UYK2 Cluster: Silent information regulator protein Si... 68 2e-10
UniRef50_A0PU12 Cluster: Sir2-like regulatory protein; n=1; Myco... 68 2e-10
UniRef50_Q8R216 Cluster: NAD-dependent deacetylase sirtuin-4; n=... 68 2e-10
UniRef50_Q8IRR5 Cluster: CG3187-PC, isoform C; n=4; Diptera|Rep:... 68 2e-10
UniRef50_Q7JMD3 Cluster: Putative uncharacterized protein sir-2.... 67 3e-10
UniRef50_A4A8B4 Cluster: Silent information regulator protein Si... 67 4e-10
UniRef50_Q5BVX8 Cluster: SJCHGC08739 protein; n=1; Schistosoma j... 67 4e-10
UniRef50_A1CTI6 Cluster: SIR2 family histone deacetylase, putati... 66 6e-10
UniRef50_Q6MJJ2 Cluster: NAD-dependent deacetylase; n=5; Proteob... 66 6e-10
UniRef50_Q6AF12 Cluster: Regulatory protein, Sir2 family; n=2; A... 66 9e-10
UniRef50_Q1QTH0 Cluster: Silent information regulator protein Si... 66 9e-10
UniRef50_A3LRA1 Cluster: Transcriptional regulatory protein; n=2... 66 9e-10
UniRef50_Q1RPU9 Cluster: Zinc finger protein; n=1; Ciona intesti... 65 1e-09
UniRef50_Q7S223 Cluster: Putative uncharacterized protein NCU059... 65 1e-09
UniRef50_A4RCT8 Cluster: Putative uncharacterized protein; n=3; ... 65 1e-09
UniRef50_A3ZMQ7 Cluster: Sir2 family, possible ADP ribosyltransf... 65 1e-09
UniRef50_A3WK56 Cluster: SIR2-like regulatory protein, NAD-depen... 65 1e-09
UniRef50_O07595 Cluster: NAD-dependent deacetylase; n=3; Bacillu... 64 2e-09
UniRef50_Q1D9X2 Cluster: Sir2 family protein; n=1; Myxococcus xa... 64 3e-09
UniRef50_A6SP88 Cluster: Putative uncharacterized protein; n=2; ... 64 3e-09
UniRef50_Q9Y6E7 Cluster: NAD-dependent deacetylase sirtuin-4; n=... 64 3e-09
UniRef50_Q882K4 Cluster: NAD-dependent deacetylase 3; n=5; Pseud... 64 3e-09
UniRef50_Q9USN7 Cluster: Sir2 family histone deacetylase Hst2; n... 63 5e-09
UniRef50_A4QUX8 Cluster: Putative uncharacterized protein; n=1; ... 63 6e-09
UniRef50_Q54LF0 Cluster: Ankyrin repeat-containing protein; n=1;... 62 8e-09
UniRef50_Q3S8X8 Cluster: IS-Sir2; n=3; Pseudomonas syringae grou... 62 1e-08
UniRef50_Q8R984 Cluster: NAD-dependent deacetylase 2; n=1; Therm... 62 1e-08
UniRef50_A6TNA0 Cluster: Silent information regulator protein Si... 62 1e-08
UniRef50_A2F8E1 Cluster: Transcriptional regulator, Sir2 family ... 62 1e-08
UniRef50_Q9RL35 Cluster: NAD-dependent deacetylase 1; n=8; Actin... 62 1e-08
UniRef50_Q839C6 Cluster: NAD-dependent deacetylase; n=14; Bacill... 61 2e-08
UniRef50_Q8REC3 Cluster: NAD-dependent deacetylase; n=3; Fusobac... 60 3e-08
UniRef50_A6G0H3 Cluster: Silent information regulator protein Si... 60 4e-08
UniRef50_Q89LY4 Cluster: NAD-dependent deacetylase 1; n=12; Prot... 60 4e-08
UniRef50_Q3A6W7 Cluster: NAD-dependent protein deacetylases, SIR... 60 6e-08
UniRef50_Q0AY57 Cluster: Regulatory protein, sir2 family; n=1; S... 59 7e-08
UniRef50_A0Z2E4 Cluster: NAD-dependent deacetylase; n=1; marine ... 59 7e-08
UniRef50_A5DW75 Cluster: Putative uncharacterized protein; n=1; ... 59 7e-08
UniRef50_UPI0000499DEA Cluster: Sir2 family transcriptional regu... 59 1e-07
UniRef50_Q21921 Cluster: NAD-dependent deacetylase SIR2 homolog;... 58 1e-07
UniRef50_Q8G465 Cluster: Sir2-type regulatory protein; n=2; Bifi... 58 2e-07
UniRef50_A6WG46 Cluster: Silent information regulator protein Si... 58 2e-07
UniRef50_Q8N6T7 Cluster: Mono-ADP-ribosyltransferase sirtuin-6; ... 58 2e-07
UniRef50_A1A3R7 Cluster: Sir2-type regulatory protein; n=2; Bifi... 57 3e-07
UniRef50_Q22KA8 Cluster: Transcriptional regulator, Sir2 family ... 57 3e-07
UniRef50_A2DZ01 Cluster: Transcriptional regulator, Sir2 family ... 57 3e-07
UniRef50_Q3V7G9 Cluster: Putative cobalamin biosynthetic protein... 57 4e-07
UniRef50_Q5KZE8 Cluster: NAD-dependent deacetylase 2; n=3; Bacte... 57 4e-07
UniRef50_Q54QE6 Cluster: Zn finger-containing protein; n=5; Euka... 56 5e-07
UniRef50_UPI00006CA40C Cluster: transcriptional regulator, Sir2 ... 56 7e-07
UniRef50_UPI0000E49AD8 Cluster: PREDICTED: similar to NAD-depend... 56 9e-07
UniRef50_Q3F1F4 Cluster: SIR2 family protein; n=1; Bacillus thur... 56 9e-07
UniRef50_Q011Q8 Cluster: NAD-dependent deacetylase SIRT2; n=2; O... 56 9e-07
UniRef50_UPI0000E49846 Cluster: PREDICTED: similar to Sirtuin (s... 55 2e-06
UniRef50_A1ZPG8 Cluster: NAD-dependent deacetylase; n=1; Microsc... 55 2e-06
UniRef50_A2DP91 Cluster: Transcriptional regulator, Sir2 family ... 54 2e-06
UniRef50_Q5KDE0 Cluster: NAD-dependent histone deacetylase, puta... 54 2e-06
UniRef50_UPI0000D55B5A Cluster: PREDICTED: similar to CG5216-PA;... 54 3e-06
UniRef50_Q9I4E1 Cluster: NAD-dependent deacetylase 2; n=6; Pseud... 54 3e-06
UniRef50_A1DG07 Cluster: SIR2 family histone deacetylase, putati... 53 5e-06
UniRef50_Q885X7 Cluster: NAD-dependent deacetylase 2; n=4; Pseud... 53 5e-06
UniRef50_UPI0000F1D51E Cluster: PREDICTED: hypothetical protein;... 53 6e-06
UniRef50_A2F8N6 Cluster: Transcriptional regulator, Sir2 family ... 53 6e-06
UniRef50_Q96EB6 Cluster: NAD-dependent deacetylase sirtuin-1; n=... 53 6e-06
UniRef50_UPI000051AA14 Cluster: PREDICTED: similar to NAD-depend... 52 9e-06
UniRef50_Q4WFZ3 Cluster: SIR2 family histone deacetylase, putati... 52 9e-06
UniRef50_O94066 Cluster: Transcription regulatory protein; n=6; ... 52 9e-06
UniRef50_Q9FE17 Cluster: Sir2-like protein; n=9; Magnoliophyta|R... 52 1e-05
UniRef50_Q75DM1 Cluster: ABL004Wp; n=1; Eremothecium gossypii|Re... 52 1e-05
UniRef50_Q9NRC8 Cluster: NAD-dependent deacetylase sirtuin-7; n=... 52 1e-05
UniRef50_UPI00015B57C0 Cluster: PREDICTED: similar to GA18743-PA... 52 1e-05
UniRef50_Q7PS76 Cluster: ENSANGP00000025231; n=1; Anopheles gamb... 52 1e-05
UniRef50_Q22ZC3 Cluster: Transcriptional regulator, Sir2 family ... 52 1e-05
UniRef50_A2F9H1 Cluster: Transcriptional regulator, Sir2 family ... 52 1e-05
UniRef50_Q88ZA0 Cluster: NAD-dependent deacetylase; n=4; Lactoba... 52 1e-05
UniRef50_Q8FUC8 Cluster: NAD-dependent deacetylase 1; n=6; Coryn... 52 1e-05
UniRef50_A0DQW0 Cluster: Chromosome undetermined scaffold_6, who... 51 3e-05
UniRef50_Q54P49 Cluster: Zn finger-containing protein; n=1; Dict... 50 3e-05
UniRef50_A7EC18 Cluster: Putative uncharacterized protein; n=1; ... 50 3e-05
UniRef50_O59923 Cluster: NAD-dependent histone deacetylase SIR2;... 50 3e-05
UniRef50_Q9VH08 Cluster: CG6284-PA; n=9; Eumetazoa|Rep: CG6284-P... 50 5e-05
UniRef50_Q7SCL4 Cluster: Putative uncharacterized protein NCU005... 50 5e-05
UniRef50_A6RXY5 Cluster: Putative uncharacterized protein; n=2; ... 50 5e-05
UniRef50_Q8R104 Cluster: NAD-dependent deacetylase sirtuin-3; n=... 50 5e-05
UniRef50_O96505 Cluster: SIR2; n=4; Sophophora|Rep: SIR2 - Droso... 50 6e-05
UniRef50_Q25337 Cluster: NAD-dependent deacetylase SIR2 homolog;... 50 6e-05
UniRef50_UPI00004997CB Cluster: Sir2 family transcriptional regu... 49 8e-05
UniRef50_A5AF92 Cluster: Putative uncharacterized protein; n=1; ... 49 8e-05
UniRef50_Q6FKU1 Cluster: Similar to sp|P53686 Saccharomyces cere... 49 8e-05
UniRef50_A1CD03 Cluster: SIR2 family histone deacetylase, putati... 49 8e-05
UniRef50_Q4DP02 Cluster: Silent information regulator 2, putativ... 49 1e-04
UniRef50_Q23E36 Cluster: Transcriptional regulator, Sir2 family ... 49 1e-04
UniRef50_A7AWG1 Cluster: Transcriptional regulator, Sir2 family ... 49 1e-04
UniRef50_A0C6J0 Cluster: Chromosome undetermined scaffold_152, w... 49 1e-04
UniRef50_Q8IXJ6 Cluster: NAD-dependent deacetylase sirtuin-2; n=... 49 1e-04
UniRef50_Q9JN05 Cluster: NAD-dependent deacetylase; n=13; Campyl... 49 1e-04
UniRef50_Q298C7 Cluster: GA18650-PA; n=1; Drosophila pseudoobscu... 48 1e-04
UniRef50_Q8N6T7-2 Cluster: Isoform 2 of Q8N6T7 ; n=5; Catarrhini... 48 2e-04
UniRef50_Q7ZVK3 Cluster: NAD-dependent deacetylase sirtuin-2; n=... 47 3e-04
UniRef50_O25849 Cluster: NAD-dependent deacetylase; n=11; Bacter... 47 3e-04
UniRef50_UPI000023DCB3 Cluster: hypothetical protein FG05505.1; ... 47 4e-04
UniRef50_Q1RL71 Cluster: Zinc finger protein; n=2; Ciona intesti... 46 6e-04
UniRef50_A7RLD5 Cluster: Predicted protein; n=1; Nematostella ve... 46 6e-04
UniRef50_Q9NTG7 Cluster: NAD-dependent deacetylase sirtuin-3, mi... 46 6e-04
UniRef50_A0JXS0 Cluster: Silent information regulator protein Si... 46 7e-04
UniRef50_Q55DB0 Cluster: NAD(+)-dependent deacetylase, silent in... 46 7e-04
UniRef50_Q0R0H8 Cluster: Sir2-like protein; n=1; Naegleria sp. T... 46 7e-04
UniRef50_A4VDQ9 Cluster: Chromatin regulatory protein sir2; n=1;... 46 7e-04
UniRef50_A2QFF9 Cluster: Complex: Sir2p is one of four Silent In... 46 7e-04
UniRef50_Q4P3S4 Cluster: Putative uncharacterized protein; n=1; ... 46 0.001
UniRef50_Q4UH74 Cluster: Sir2-like histone deacetylase, putative... 45 0.001
UniRef50_Q7VIN2 Cluster: NAD-dependent deacetylase; n=1; Helicob... 45 0.001
UniRef50_UPI000050FCF4 Cluster: COG0846: NAD-dependent protein d... 45 0.002
UniRef50_A4QX96 Cluster: Putative uncharacterized protein; n=2; ... 45 0.002
UniRef50_Q9VAQ1 Cluster: CG11305-PA; n=8; Coelomata|Rep: CG11305... 44 0.002
UniRef50_A2GAR7 Cluster: Transcriptional regulator, Sir2 family ... 44 0.002
UniRef50_Q6C219 Cluster: Yarrowia lipolytica chromosome F of str... 44 0.002
UniRef50_A3LN35 Cluster: NAD-dependent histone deacetylase SIR2;... 44 0.002
UniRef50_Q7QZ37 Cluster: GLP_464_19573_21615; n=1; Giardia lambl... 44 0.003
UniRef50_Q7SB01 Cluster: Putative uncharacterized protein NCU076... 44 0.003
UniRef50_Q4P1X1 Cluster: Putative uncharacterized protein; n=1; ... 44 0.003
UniRef50_Q07FY7 Cluster: Sirtuin (Silent mating type information... 44 0.004
UniRef50_Q1RPU3 Cluster: Zinc finger protein; n=1; Ciona intesti... 44 0.004
UniRef50_A5DNV7 Cluster: Putative uncharacterized protein; n=1; ... 44 0.004
UniRef50_UPI0000D573CE Cluster: PREDICTED: similar to CG11305-PA... 43 0.005
UniRef50_A6DES9 Cluster: Transcriptional regulator, Sir2 family ... 43 0.005
UniRef50_Q175I4 Cluster: Chromatin regulatory protein sir2; n=3;... 43 0.005
UniRef50_A7SX90 Cluster: Predicted protein; n=3; Eumetazoa|Rep: ... 43 0.005
UniRef50_A5K3P4 Cluster: Putative uncharacterized protein; n=1; ... 43 0.005
UniRef50_Q7RP35 Cluster: Sir2-like protein; n=5; Plasmodium (Vin... 43 0.007
UniRef50_Q4QB33 Cluster: Sir2-family protein-like protein; n=4; ... 43 0.007
UniRef50_Q6C8V5 Cluster: Similar to tr|Q9FY91 Arabidopsis thalia... 43 0.007
UniRef50_Q6BPH5 Cluster: Debaryomyces hansenii chromosome E of s... 43 0.007
UniRef50_UPI00015B56BB Cluster: PREDICTED: similar to ENSANGP000... 42 0.012
UniRef50_A6Q2C0 Cluster: Transcriptional regulator, Sir2 family;... 42 0.016
UniRef50_A0C2R2 Cluster: Chromosome undetermined scaffold_145, w... 42 0.016
UniRef50_Q4WET3 Cluster: SIR2 family histone deacetylase, putati... 42 0.016
UniRef50_A5DJ74 Cluster: Putative uncharacterized protein; n=1; ... 42 0.016
UniRef50_A4R235 Cluster: Putative uncharacterized protein; n=1; ... 42 0.016
UniRef50_Q03ZB1 Cluster: NAD-dependent protein deacetylase, SIR2... 41 0.021
UniRef50_Q9FY91 Cluster: SIR2-family protein; n=12; Magnoliophyt... 41 0.021
UniRef50_Q95Q89 Cluster: Yeast sir related protein 2.4; n=2; Cae... 41 0.021
UniRef50_Q7R0G2 Cluster: GLP_29_33086_34261; n=1; Giardia lambli... 41 0.028
UniRef50_A2QUR5 Cluster: Remark: the H. sapiens SIRT4 belongs to... 41 0.028
UniRef50_A0D0F1 Cluster: Chromosome undetermined scaffold_33, wh... 40 0.049
UniRef50_P06700 Cluster: NAD-dependent histone deacetylase SIR2;... 40 0.049
UniRef50_Q23YS7 Cluster: Transcriptional regulator, Sir2 family ... 40 0.065
UniRef50_A5DSX8 Cluster: NAD-dependent histone deacetylase SIR2;... 40 0.065
UniRef50_A6XDL2 Cluster: Sirtuin 1; n=2; Schistosoma|Rep: Sirtui... 39 0.085
UniRef50_Q8IKW2 Cluster: Putative uncharacterized protein; n=1; ... 39 0.11
UniRef50_Q2U9Y7 Cluster: Sirtuin 4 and related class II sirtuins... 38 0.15
UniRef50_A2DKF0 Cluster: Transcriptional regulator, Sir2 family ... 38 0.20
UniRef50_Q480E0 Cluster: Putative membrane protein; n=1; Colwell... 38 0.26
UniRef50_A7HID4 Cluster: Silent information regulator protein Si... 38 0.26
UniRef50_Q5KA61 Cluster: Histone deacetylase, putative; n=1; Fil... 38 0.26
UniRef50_A1ZMS1 Cluster: Silent information regulator protein Si... 37 0.45
UniRef50_A2DZ29 Cluster: Transcriptional regulator, Sir2 family ... 37 0.45
UniRef50_Q6ZMU6 Cluster: CDNA FLJ16662 fis, clone TESTI4046240, ... 37 0.45
UniRef50_Q8SSB6 Cluster: SIR2-LIKE PROTEIN INVOLVED IN TELOMERIC... 37 0.45
UniRef50_Q5CYK0 Cluster: Bacterial-like Sir2 family protein; n=2... 36 0.79
UniRef50_Q6CAJ8 Cluster: Similar to sp|P53687 Saccharomyces cere... 36 0.79
UniRef50_O94640 Cluster: NAD-dependent histone deacetylase sir2;... 36 0.79
UniRef50_A6Q178 Cluster: Transcription regulator, Sir2 family; n... 36 1.1
UniRef50_Q7QZ36 Cluster: GLP_464_21655_23334; n=1; Giardia lambl... 36 1.1
UniRef50_Q7S6G9 Cluster: Putative uncharacterized protein NCU047... 35 1.4
UniRef50_Q0CR31 Cluster: NAD-dependent histone deacetylase SIR2;... 35 1.4
UniRef50_A4A980 Cluster: NAD-dependent deacetylase; n=5; Gammapr... 35 1.8
UniRef50_A2Q9C4 Cluster: Contig An01c0250, complete genome; n=18... 35 1.8
UniRef50_A5C953 Cluster: Putative uncharacterized protein; n=1; ... 34 3.2
UniRef50_Q5AQ47 Cluster: Potential Sir2 family histone deacetyla... 34 3.2
UniRef50_Q2H5A0 Cluster: Putative uncharacterized protein; n=1; ... 34 3.2
UniRef50_A6SFT5 Cluster: Putative uncharacterized protein; n=1; ... 33 5.6
UniRef50_Q874C2 Cluster: Cation-transporting ATPase; n=1; Tramet... 33 7.4
UniRef50_Q55PY8 Cluster: Putative uncharacterized protein; n=2; ... 33 7.4
UniRef50_A7TQE2 Cluster: Putative uncharacterized protein; n=1; ... 33 7.4
UniRef50_A7EMW8 Cluster: Putative uncharacterized protein; n=1; ... 33 7.4
UniRef50_UPI00006A2625 Cluster: UPI00006A2625 related cluster; n... 32 9.8
UniRef50_Q3AR72 Cluster: VCBS; n=1; Chlorobium chlorochromatii C... 32 9.8
UniRef50_Q54RU1 Cluster: ABC transporter B family protein; n=1; ... 32 9.8
>UniRef50_Q9NXA8 Cluster: NAD-dependent deacetylase sirtuin-5; n=28;
Coelomata|Rep: NAD-dependent deacetylase sirtuin-5 -
Homo sapiens (Human)
Length = 310
Score = 203 bits (496), Expect = 2e-51
Identities = 101/178 (56%), Positives = 124/178 (69%), Gaps = 3/178 (1%)
Frame = +1
Query: 19 AGHFAIAKFEDNHGSQ-KKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVN 195
AGH AIA+ E G Q +++ VITQN+D LH +AGTK L+E+HG+L+KTRCT C V N
Sbjct: 116 AGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAEN 175
Query: 196 NDSPICTCK*RSPRF*YGGFD--IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAA 369
SPIC G D IPV+ LP C++A CG LLRPH+VWFGE+L+ ILE
Sbjct: 176 YKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEV 235
Query: 370 EHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEGPC 543
+ ++ CD+CLVVGTSSVVYPAAMFAPQ A+RG VAEFN E TPA F+F+GPC
Sbjct: 236 DRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPC 293
>UniRef50_UPI0000D578DC Cluster: PREDICTED: similar to sirtuin 5
(silent mating type information regulation 2 homolog) 5;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
sirtuin 5 (silent mating type information regulation 2
homolog) 5 - Tribolium castaneum
Length = 254
Score = 159 bits (385), Expect = 7e-38
Identities = 79/158 (50%), Positives = 107/158 (67%), Gaps = 2/158 (1%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQ-KKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND 201
H A+AK+E Q ++ VITQNVDGLH RAG++ ++ELHG+L K CTKCK++ VN +
Sbjct: 87 HKALAKYEKICKEQGRQFHVITQNVDGLHKRAGSENVLELHGSLDKVICTKCKQIEVNTE 146
Query: 202 SPICTCK*RSPRF*YGGFDIPVKLLPHCKK-AHCGALLRPHIVWFGESLEHDILEAAEHA 378
+PIC D+P+ L K + C AL+RP+IVWFGE+L+ D+L+ +
Sbjct: 147 NPICEALRGRGDPSKRDQDLPIIPLEELPKCSECQALVRPYIVWFGENLDPDVLDRSRQL 206
Query: 379 MSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNI 492
+ +CD+CLV+GTSSVVYPAAMFAP RG VAEFN+
Sbjct: 207 IESCDLCLVIGTSSVVYPAAMFAPTVVERGKPVAEFNL 244
>UniRef50_A7RMK8 Cluster: Predicted protein; n=5; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 273
Score = 149 bits (362), Expect = 4e-35
Identities = 78/172 (45%), Positives = 103/172 (59%), Gaps = 1/172 (0%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQ-KKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND 201
HFAIA+F+ ++ K++ V+TQN+D LH AG + +IELHG L+KTRC V
Sbjct: 93 HFAIAEFQKKMRNEGKQVWVVTQNIDELHKTAGAEDVIELHGTLFKTRCNH-----VTTQ 147
Query: 202 SPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAM 381
I +P IP+ LP C + C AL+RPH+VWFGE+L+ +L+ E +
Sbjct: 148 GSITLGIVLAPDPNAPDAKIPLTELPRCVRPECDALVRPHVVWFGEALDPVVLQQIEKVL 207
Query: 382 STCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEG 537
CD C +VGTSSVVYPAA FAP A RG VAEFN+E T F+F+G
Sbjct: 208 GECDFCFIVGTSSVVYPAAGFAPMLAQRGVPVAEFNMEETSCTGQFSFHFQG 259
>UniRef50_Q8ZT00 Cluster: NAD-dependent deacetylase 2; n=2; cellular
organisms|Rep: NAD-dependent deacetylase 2 - Pyrobaculum
aerophilum
Length = 249
Score = 120 bits (290), Expect = 2e-26
Identities = 75/177 (42%), Positives = 99/177 (55%)
Frame = +1
Query: 7 ANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEV 186
A + GH+AIA+ E G + VITQNVDGLH RAG++ ++ELHG++++ RC KC V
Sbjct: 72 ARPSPGHYAIAELEAM-GVVRG--VITQNVDGLHQRAGSRLVVELHGSIWRARCVKCGSV 128
Query: 187 LVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEA 366
+ D P+ ++P P C+K CG LLRP +VWFGE L + A
Sbjct: 129 YIL-DKPV--------------EEVP----PLCRK--CGGLLRPDVVWFGEPLPQEAWRA 167
Query: 367 AEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEG 537
A S DV LVVGTS VVYPAA A GA V E N+EP+ I+ + +G
Sbjct: 168 AVELASVSDVLLVVGTSGVVYPAAYIPRIAKEAGARVVEINVEPSAITPIADVFIQG 224
>UniRef50_Q8U1Q1 Cluster: NAD-dependent deacetylase; n=19; cellular
organisms|Rep: NAD-dependent deacetylase - Pyrococcus
furiosus
Length = 250
Score = 114 bits (275), Expect = 1e-24
Identities = 75/180 (41%), Positives = 95/180 (52%), Gaps = 2/180 (1%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKC-- 177
+A H A+A+ E G K VITQNVD LH AG+K +IELHGN+++ +CT C
Sbjct: 73 EAKPNPAHIALAELE-KMGIIK--AVITQNVDDLHREAGSKNVIELHGNIFRVKCTSCSY 129
Query: 178 KEVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDI 357
+E L +D G+ + +L P C K CG+LLRP +VWFGE+L
Sbjct: 130 REYLKESDRI--------------GWLLSQEL-PRCPK--CGSLLRPDVVWFGEALPEKE 172
Query: 358 LEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEG 537
L A DV LVVGTS VVYPAA G IV E NIEP+ I+ F+ G
Sbjct: 173 LTTAFSLAKKADVVLVVGTSGVVYPAAYIPYIVKESGGIVVEINIEPSAITPIADFFLRG 232
>UniRef50_Q9CBW6 Cluster: NAD-dependent deacetylase; n=14;
Mycobacterium|Rep: NAD-dependent deacetylase -
Mycobacterium leprae
Length = 237
Score = 109 bits (261), Expect = 7e-23
Identities = 69/162 (42%), Positives = 89/162 (54%), Gaps = 1/162 (0%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND 201
GH AIA +++ Q +++VITQNVD LH RAG+ + LHG+L+K C +C V
Sbjct: 68 GHRAIAAWQE----QIEVSVITQNVDDLHERAGSTPVHHLHGSLFKFHCARCN-VAYTGA 122
Query: 202 SPICTCK*RSPRF*YGGFDIPVKLLP-HCKKAHCGALLRPHIVWFGESLEHDILEAAEHA 378
P D+P +L +CG L+RP IVWFGE L + A A
Sbjct: 123 LP----------------DMPEPVLEVDPPVCYCGGLIRPAIVWFGEPLPDEPWRRAVEA 166
Query: 379 MSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
T DV +VVGTS++VYPAA A SRGA+V E N EPTP
Sbjct: 167 TETTDVMVVVGTSAIVYPAAGLPELALSRGAVVIEVNPEPTP 208
>UniRef50_Q0LFI4 Cluster: Silent information regulator protein Sir2;
n=1; Herpetosiphon aurantiacus ATCC 23779|Rep: Silent
information regulator protein Sir2 - Herpetosiphon
aurantiacus ATCC 23779
Length = 171
Score = 105 bits (252), Expect = 9e-22
Identities = 68/163 (41%), Positives = 88/163 (53%), Gaps = 1/163 (0%)
Frame = +1
Query: 19 AGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE-VLVN 195
AGH A+A+ E + S +T+ITQN+DGLH RAG+ R+IELHG + C+ + L
Sbjct: 8 AGHVALAQLEQHIPS---VTIITQNIDGLHQRAGSTRVIELHGTINTVSCSAAEHGSLAW 64
Query: 196 NDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEH 375
DSP LP C C A LRP +VWFGE L+ ++AAE
Sbjct: 65 PDSPN---------------------LPFCSV--CAAPLRPDVVWFGERLDLAKIQAAEL 101
Query: 376 AMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
A TCDV L +GTS VV PAA F A + A + + N+E TP
Sbjct: 102 ASQTCDVFLAIGTSGVVAPAATFPMTARAHRARLIDLNLEDTP 144
>UniRef50_Q3E2I1 Cluster: Silent information regulator protein Sir2;
n=7; Bacteria|Rep: Silent information regulator protein
Sir2 - Chloroflexus aurantiacus J-10-fl
Length = 254
Score = 104 bits (250), Expect = 2e-21
Identities = 67/156 (42%), Positives = 85/156 (54%)
Frame = +1
Query: 70 KITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YG 249
++T++TQN+DGLH RAG+ ++IELHGN+++ RCT D I T
Sbjct: 99 RLTLVTQNIDGLHQRAGSPQVIELHGNIHRARCTV--------DGSIHTT---------- 140
Query: 250 GFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVY 429
+D +L P C +CGALLRP +VWFGE L LEAA A CDV +GTS VV
Sbjct: 141 -WDYDEEL-PQCP--NCGALLRPDVVWFGEYLPPGALEAAYAATLDCDVFCSIGTSGVVE 196
Query: 430 PAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEG 537
PAA A SRGA V N+E T +F G
Sbjct: 197 PAASLPRIALSRGATVLILNLEQTTTARSPLFTVYG 232
>UniRef50_Q8Y015 Cluster: NAD-dependent deacetylase; n=11;
Bacteria|Rep: NAD-dependent deacetylase - Ralstonia
solanacearum (Pseudomonas solanacearum)
Length = 246
Score = 101 bits (242), Expect = 1e-20
Identities = 68/163 (41%), Positives = 82/163 (50%), Gaps = 4/163 (2%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTR----CTKCKEVLV 192
H AIA ++K + ++TQNVDGLH RAG+ +IELHGNL+ + C KC
Sbjct: 90 HLAIAAL----ATRKTVALVTQNVDGLHQRAGSVGVIELHGNLFANKWLDGCGKCDVATA 145
Query: 193 NNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAE 372
P P C A CGA+LRP +VWFGE L AE
Sbjct: 146 EPGRP-----------------------PRC--AACGAMLRPGVVWFGERLPVVANYRAE 180
Query: 373 HAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
A +TCDVCLVVGTS +VYPAA A GA V N EP+
Sbjct: 181 EAANTCDVCLVVGTSGMVYPAAGLPGLAKDHGARVIVVNPEPS 223
>UniRef50_A5WD15 Cluster: Silent information regulator protein Sir2;
n=2; Psychrobacter|Rep: Silent information regulator
protein Sir2 - Psychrobacter sp. PRwf-1
Length = 249
Score = 97.9 bits (233), Expect = 2e-19
Identities = 65/174 (37%), Positives = 92/174 (52%), Gaps = 8/174 (4%)
Frame = +1
Query: 25 HFAIAKFE----DNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKC----K 180
H+A+A + DNH K ++ITQNVD LH +AG++ I LHG+L+K +C++C
Sbjct: 84 HYALANLQQWATDNH---KDCSLITQNVDDLHEQAGSQA-IHLHGHLWKNKCSQCDASFS 139
Query: 181 EVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDIL 360
+ + ND + +C P+ CG +RP IVWFGE L
Sbjct: 140 DAIDYNDLQLLSC--------------PM----------CGGHIRPDIVWFGEMLPQGAW 175
Query: 361 EAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISI 522
+ AE A CDV + +GTSS+VYPAA A A GA V E N+ PT + L+ +
Sbjct: 176 QYAEEAAVHCDVFISIGTSSLVYPAAGLAQLAKQTGAKVIEINLNPTQSPLVDV 229
>UniRef50_A1FG80 Cluster: Silent information regulator protein Sir2;
n=3; Pseudomonas|Rep: Silent information regulator
protein Sir2 - Pseudomonas putida W619
Length = 252
Score = 96.7 bits (230), Expect = 4e-19
Identities = 61/163 (37%), Positives = 83/163 (50%), Gaps = 1/163 (0%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE 183
+A A H AI + GS + +TV+TQN+D LH RAG + ++ LHG+L + +C C
Sbjct: 76 QAKPNAAHQAIHRLS---GSGRSVTVVTQNIDDLHERAGNQEVLHLHGSLMRPKCFACHR 132
Query: 184 VLVNN-DSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDIL 360
+V PI + G P P C++ C LRP IVWFGE L +
Sbjct: 133 FVVEPLVFPIIPAE--------GALIEP----PRCRR--CNGRLRPAIVWFGEYLPPGVW 178
Query: 361 EAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFN 489
+AA A CD+ L +GTS VV PAA A + GA+V N
Sbjct: 179 KAASQAARQCDILLSIGTSGVVRPAADLPDIALASGAVVIHVN 221
>UniRef50_A7DQD6 Cluster: Silent information regulator protein Sir2;
n=1; Candidatus Nitrosopumilus maritimus SCM1|Rep:
Silent information regulator protein Sir2 - Candidatus
Nitrosopumilus maritimus SCM1
Length = 242
Score = 94.7 bits (225), Expect = 2e-18
Identities = 61/165 (36%), Positives = 86/165 (52%)
Frame = +1
Query: 7 ANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEV 186
AN GH AIA+ E + +TQN+DGLH +AG+ +++ELHG++ K +CT C
Sbjct: 76 ANPNQGHKAIAELE----KFADVVSLTQNIDGLHQKAGSTKVLELHGSIVKIKCTVC--- 128
Query: 187 LVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEA 366
+ I T +P P CK CG++LRP +VWFGESL D+ +
Sbjct: 129 --DFSDEIMTDFTENP--------------PLCK---CGSILRPDVVWFGESLPQDVWQE 169
Query: 367 AEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
A + CD+ ++VGTS VV PA A A++ E N E T
Sbjct: 170 AIIHANQCDLMIIVGTSLVVSPANTLPIYAKQNNAMLIEINPENT 214
>UniRef50_Q1D737 Cluster: NAD-dependent deacetylase; n=1; Myxococcus
xanthus DK 1622|Rep: NAD-dependent deacetylase -
Myxococcus xanthus (strain DK 1622)
Length = 245
Score = 93.9 bits (223), Expect = 3e-18
Identities = 62/165 (37%), Positives = 82/165 (49%), Gaps = 6/165 (3%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND 201
GH A+ +E + G + + TQNVDGLH RAG++R++E+HGNL+KTRC++C
Sbjct: 76 GHEALVAWERHLGD--RFLLATQNVDGLHTRAGSQRVVEMHGNLFKTRCSRCGR------ 127
Query: 202 SPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLE-HDILEAAEHA 378
P F P +P C CG LLRPHIVWFGE L+ DI + +
Sbjct: 128 ----------PPF-EDATVYPAGAVPECDA--CGKLLRPHIVWFGEYLDPADIQRIEDFS 174
Query: 379 MSTCD-----VCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEP 498
+ V L GTS VYPAA Q G N++P
Sbjct: 175 LRAATSGGRFVFLAAGTSGAVYPAAGIVDQVRKAGGKTWLVNLDP 219
>UniRef50_Q8FRV5 Cluster: NAD-dependent deacetylase 2; n=9;
Corynebacterineae|Rep: NAD-dependent deacetylase 2 -
Corynebacterium efficiens
Length = 254
Score = 93.9 bits (223), Expect = 3e-18
Identities = 60/174 (34%), Positives = 88/174 (50%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE 183
KA AGH IA +E +H + V TQN+D LH RAG+ + LHG+L++ RC+ C +
Sbjct: 78 KARPNAGHETIAYWEGSH-LVDAVHVTTQNIDNLHERAGSTEVTHLHGSLFEFRCSICSK 136
Query: 184 VLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILE 363
++ PR PV+ L + CG +RP +VWFGE+L +
Sbjct: 137 PWRDDGD--------YPRE-------PVERLAPPTCSLCGNPVRPGVVWFGEALPQEEWA 181
Query: 364 AAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIF 525
AE M D+ ++VGTS +VYPAA A RG + E + T + I+ +
Sbjct: 182 VAERRMREADLVVIVGTSGIVYPAASLPVLAHQRGVPILEITPKETDLSRIATY 235
>UniRef50_Q0LN22 Cluster: Silent information regulator protein Sir2;
n=1; Herpetosiphon aurantiacus ATCC 23779|Rep: Silent
information regulator protein Sir2 - Herpetosiphon
aurantiacus ATCC 23779
Length = 243
Score = 93.1 bits (221), Expect = 5e-18
Identities = 66/179 (36%), Positives = 93/179 (51%), Gaps = 2/179 (1%)
Frame = +1
Query: 7 ANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEV 186
A AGH+A+A+ E G+Q K+ TQN+D LH RAG+ ++ E+HG+L +T C++ +
Sbjct: 79 AQPNAGHYALAQLEQL-GTQFKL--FTQNIDSLHQRAGSSQVYEVHGSLARTICSREGNL 135
Query: 187 LV--NNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDIL 360
+ N + PIC CGA LRP IVWFGE L+ IL
Sbjct: 136 VETWNAEQPICPA--------------------------CGAPLRPDIVWFGELLDAGIL 169
Query: 361 EAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEG 537
+AA+ A + DV LV+GTS++V P A +A R V E N + P I+ F G
Sbjct: 170 QAAKAAFDSSDVALVIGTSAIVEPIASLPHRALRRKKTVIEINPD-IPLRGIATFSLAG 227
>UniRef50_Q9RYD4 Cluster: NAD-dependent deacetylase; n=4;
Deinococci|Rep: NAD-dependent deacetylase - Deinococcus
radiodurans
Length = 246
Score = 92.7 bits (220), Expect = 7e-18
Identities = 69/164 (42%), Positives = 86/164 (52%), Gaps = 4/164 (2%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTK----RLIELHGNLYKTRCTKCKEVL 189
GH +A+ E G + TQNVDGLHARAG+ L+ELHGNL + R EV
Sbjct: 81 GHELLAELERRKGPG--FFLATQNVDGLHARAGSGSAGGELVELHGNLLQARDELTGEVF 138
Query: 190 VNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAA 369
P+ +P +P L P+ G +RPHIVWFGE L D L+AA
Sbjct: 139 -----PLA-----AP----DELTLP-PLSPN------GQRMRPHIVWFGEYLPVDALDAA 177
Query: 370 EHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
+ A + +V LV+GTSSVVYPAA A + RG V E N E T
Sbjct: 178 QRAFAGAEVALVIGTSSVVYPAAGLAAETLRRGGAVIEINPEAT 221
>UniRef50_Q0LIC7 Cluster: Silent information regulator protein Sir2;
n=2; Bacteria|Rep: Silent information regulator protein
Sir2 - Herpetosiphon aurantiacus ATCC 23779
Length = 244
Score = 92.3 bits (219), Expect = 9e-18
Identities = 60/164 (36%), Positives = 84/164 (51%)
Frame = +1
Query: 19 AGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNN 198
A H A+A+FE + G ++ T+ITQN+DGLH AG++ L+E HG+L ++RC+
Sbjct: 76 AAHRALARFEQSLGKHQRFTLITQNIDGLHQLAGSRNLVEFHGSLRQSRCSD-----EQC 130
Query: 199 DSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHA 378
D P + + LP C CG LRP IV F E++ A+ +
Sbjct: 131 DQPS-----------FVDQRAHTQTLPLCPT--CGKPLRPDIVLFEEAIPVWAETQAKRS 177
Query: 379 MSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPAN 510
+ CD L VGTS V+PAA FA A GA N+EP A+
Sbjct: 178 LRECDFFLAVGTSGTVFPAAAFARTAQMLGARTMLVNLEPHAAD 221
>UniRef50_A5K7T7 Cluster: NAD-dependent deacetylase, putative; n=5;
Plasmodium|Rep: NAD-dependent deacetylase, putative -
Plasmodium vivax
Length = 306
Score = 91.9 bits (218), Expect = 1e-17
Identities = 56/160 (35%), Positives = 86/160 (53%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND 201
GH A++K E + G K TVITQN+DGLH +G ++I LHG++++ RC C+E + N
Sbjct: 95 GHTALSKLE-SLGYLK--TVITQNIDGLHEESGNSKVIPLHGSVFEARCCTCRETIQLNK 151
Query: 202 SPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAM 381
+ ++ F + +L P C CG + +P++V FGE + +L+ AE +
Sbjct: 152 IMLQ----KTSHFMH-------QLPPECP---CGGIFKPNVVLFGEVIPKSLLKQAEKEI 197
Query: 382 STCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
CD+ LV+GTSS V A A + + E NI T
Sbjct: 198 DKCDLLLVIGTSSTVSTATNLCYHAHRKKKKIVEVNISKT 237
>UniRef50_Q607X6 Cluster: NAD-dependent deacetylase; n=1;
Methylococcus capsulatus|Rep: NAD-dependent deacetylase
- Methylococcus capsulatus
Length = 255
Score = 91.9 bits (218), Expect = 1e-17
Identities = 60/162 (37%), Positives = 82/162 (50%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE 183
+A H+AIA ++T+ITQNVD LH RAG+ I LHG+L+ RC+ C
Sbjct: 76 RAEPNPAHYAIAALA---ADCPRLTLITQNVDDLHERAGSADPIRLHGSLHHPRCSAC-- 130
Query: 184 VLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILE 363
++P P GG + P C A CGA +RP +VW GE+L +
Sbjct: 131 -----EAPY-RLPPGIPDEPEGGRRVDP---PRC--ARCGAPVRPGVVWLGENLPQAAWD 179
Query: 364 AAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFN 489
AA A CD+ +GTS++V+PAA A RGA V + N
Sbjct: 180 AARQAAEDCDLMFSIGTSALVWPAAQLPALVARRGATVVQVN 221
>UniRef50_Q8F3Z6 Cluster: NAD-dependent deacetylase; n=4;
Leptospira|Rep: NAD-dependent deacetylase - Leptospira
interrogans
Length = 246
Score = 89.4 bits (212), Expect = 6e-17
Identities = 59/162 (36%), Positives = 81/162 (50%), Gaps = 4/162 (2%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKC----KEVL 189
GHFA+ + E H +ITQNVDGLH++AG+K+L E+HGN++ RC C KE +
Sbjct: 79 GHFALVELERIHPD---FFLITQNVDGLHSQAGSKKLTEIHGNIFINRCISCGQESKETI 135
Query: 190 VNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAA 369
N +P L P C+ +C + LRP +VWFGES + L +
Sbjct: 136 SENTTP---------------------LPPQCQ--NCNSFLRPGVVWFGESYDDFKLNLS 172
Query: 370 EHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIE 495
M D+ LV+GTS V A A GA++ E N E
Sbjct: 173 IQRMKHTDLLLVLGTSGSVSMPVYLAQIAKDSGALLIEINPE 214
>UniRef50_A0LG97 Cluster: Silent information regulator protein Sir2;
n=1; Syntrophobacter fumaroxidans MPOB|Rep: Silent
information regulator protein Sir2 - Syntrophobacter
fumaroxidans (strain DSM 10017 / MPOB)
Length = 248
Score = 88.6 bits (210), Expect = 1e-16
Identities = 58/163 (35%), Positives = 81/163 (49%)
Frame = +1
Query: 1 AKANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCK 180
A+ N+ H A+A E G K++ +TQN+D LH RAG+K +IE HG+ RC +C+
Sbjct: 76 ARPNFA--HLALADLE-KRGIVKEL--VTQNIDSLHQRAGSKNVIEFHGHNRSLRCDRCQ 130
Query: 181 EVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDIL 360
+V + T L P C CG LRP IV+FGE +
Sbjct: 131 KVYARESVSLAT------------------LPPACA---CGNALRPEIVFFGEDIPPQAY 169
Query: 361 EAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFN 489
+A +A CD ++VGTS+ V PA+ A SRGA + E N
Sbjct: 170 RSALNAAQKCDFMMIVGTSASVAPASQLPLVAKSRGAFILEIN 212
>UniRef50_Q8ZFR1 Cluster: NAD-dependent deacetylase; n=149; cellular
organisms|Rep: NAD-dependent deacetylase - Yersinia
pestis
Length = 278
Score = 87.8 bits (208), Expect = 2e-16
Identities = 60/161 (37%), Positives = 82/161 (50%)
Frame = +1
Query: 19 AGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNN 198
A HFA+A E G + +ITQN+D LH RAG+KR+I +HG L K RCT+ +VL
Sbjct: 106 AAHFALADLEAVLGDN--LVLITQNIDNLHERAGSKRVIHMHGELLKVRCTQSGQVLD-- 161
Query: 199 DSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHA 378
+ G D+ HC + LRPHIVWFGE ++ A
Sbjct: 162 ---------------WQG-DLSADERCHC--CQFPSPLRPHIVWFGEMPMG--MDDIYQA 201
Query: 379 MSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
++ D + +GTS VYPAA F ++ GA E N+EP+
Sbjct: 202 LAEADFFISIGTSGHVYPAAGFVHESHLHGAHTVELNLEPS 242
>UniRef50_Q6C8C7 Cluster: Similar to DEHA0C01507g Debaryomyces
hansenii IPF 2468.1; n=2; Ascomycota|Rep: Similar to
DEHA0C01507g Debaryomyces hansenii IPF 2468.1 - Yarrowia
lipolytica (Candida lipolytica)
Length = 303
Score = 87.4 bits (207), Expect = 2e-16
Identities = 62/175 (35%), Positives = 92/175 (52%), Gaps = 11/175 (6%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAG--TKRLIELHGNLYKTRCTK- 174
KA GH+A+A+ + + +TQNVDGL +RA + L++LHG+L+ +CT
Sbjct: 77 KAKPNPGHYALAELARR--LRGRFLTLTQNVDGLSSRAEHPQEALLKLHGDLFALKCTSF 134
Query: 175 -CKEVLVNNDS-PICTCK*RSPRF*YGGFD---IPVKLLPHCKKAHCG-ALLRPHIVWFG 336
C +N + P+ + + IPV+ LP C HC LLRP +VWFG
Sbjct: 135 FCSYTTEDNFADPLTPALSITDNYNSAQLQRHRIPVEDLPTCP--HCKEGLLRPGVVWFG 192
Query: 337 ESLEHDILEAAEHAM--STCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIE 495
ESL ++ A+ + D+ +VVGTS V+PAA + + A G VA FN+E
Sbjct: 193 ESLPFKVMNTADEFLEDEDVDLIIVVGTSGSVWPAAGYVERVALSGGKVAIFNME 247
>UniRef50_Q21KQ1 Cluster: Silent information regulator protein Sir2;
n=2; Gammaproteobacteria|Rep: Silent information
regulator protein Sir2 - Saccharophagus degradans
(strain 2-40 / ATCC 43961 / DSM 17024)
Length = 235
Score = 85.4 bits (202), Expect = 1e-15
Identities = 61/172 (35%), Positives = 86/172 (50%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H A+ +FE + + ++TQNVD LH G+K LI +HG L K RC ++V +D
Sbjct: 76 HTALGEFEQHFSGE--FLLVTQNVDNLHELGGSKNLIHMHGELLKARCPVSEKV---SD- 129
Query: 205 PICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMS 384
CT D+ + L C+ LLRPHIVWFGE ++ E A+
Sbjct: 130 --CTK------------DLTDQSL--CECCTPPNLLRPHIVWFGEMPL--AMDTIEQALC 171
Query: 385 TCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEGP 540
CD+ + +GTS VYPAA F AAS GA E N++ + + +GP
Sbjct: 172 ECDLFVSIGTSGNVYPAAGFVELAASYGATTVELNLDASANSRAFDTSLQGP 223
>UniRef50_Q4APN6 Cluster: Silent information regulator protein Sir2;
n=1; Chlorobium phaeobacteroides BS1|Rep: Silent
information regulator protein Sir2 - Chlorobium
phaeobacteroides BS1
Length = 217
Score = 84.6 bits (200), Expect = 2e-15
Identities = 52/144 (36%), Positives = 76/144 (52%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
V+TQN+DG+H RAG+K +IELHG+L++ R C+ +C R D
Sbjct: 76 VVTQNIDGMHQRAGSKDVIELHGSLWRLR---CQ-----------SCGFRKE-------D 114
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
+ + CG LRP I+WFG+ L+ ++ A A+ CD+ + +GTS V+PAA
Sbjct: 115 LAESY--ETTRCDCGDRLRPDIIWFGDMLDAVVMSKASQAIRNCDLFVSIGTSGTVWPAA 172
Query: 439 MFAPQAASRGAIVAEFNIEPTPAN 510
F A GA E N EP+ A+
Sbjct: 173 GFPDLAKQSGAYCIEINPEPSGAS 196
>UniRef50_Q2YZT2 Cluster: Putative uncharacterized protein; n=1;
uncultured delta proteobacterium|Rep: Putative
uncharacterized protein - uncultured delta
proteobacterium
Length = 254
Score = 84.6 bits (200), Expect = 2e-15
Identities = 57/166 (34%), Positives = 83/166 (50%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE 183
+A H+A+AK E G K I ITQN+D +H RAG+K +IE HGN CTKCK+
Sbjct: 76 QAKPNRAHYALAKLEAA-GILKAI--ITQNIDNMHQRAGSKNVIEFHGNAETLTCTKCKK 132
Query: 184 VLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILE 363
+ + + IP P C+ C ++RP +V+FGE++
Sbjct: 133 KFTREEITMES--------------IP----PLCE---CKGVIRPDVVFFGETIPAHATR 171
Query: 364 AAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
A + C + LV+GTS+ V PA+ +A GAI+ E N+ T
Sbjct: 172 MAGKEVEKCAMILVIGTSADVAPASRLPIKAKEGGAIIVEINLRET 217
>UniRef50_A4J646 Cluster: Silent information regulator protein Sir2;
n=2; Peptococcaceae|Rep: Silent information regulator
protein Sir2 - Desulfotomaculum reducens MI-1
Length = 256
Score = 84.6 bits (200), Expect = 2e-15
Identities = 65/179 (36%), Positives = 87/179 (48%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE 183
KA HFA+A+ E + VITQN+DGLH AG+KR+ E+HGNL C CK+
Sbjct: 79 KAKPNNAHFALARLEKMGWL---LGVITQNIDGLHQHAGSKRVWEVHGNLKGCSCLSCKK 135
Query: 184 VLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILE 363
FD+ +L + CG LLRP +V FG+++ D
Sbjct: 136 Q----------------------FDMG-QLHKQLRCPFCGGLLRPDVVLFGDAMPEDFF- 171
Query: 364 AAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEGP 540
AE MS C + LV+G+S VYP A PQ +S+ I+ N EPT + S F P
Sbjct: 172 MAEKVMSGCQLLLVIGSSLQVYPVASL-PQLSSKTVII---NKEPTTWDKHSDVVFHEP 226
>UniRef50_A5USR3 Cluster: Silent information regulator protein Sir2;
n=3; Chloroflexi (class)|Rep: Silent information
regulator protein Sir2 - Roseiflexus sp. RS-1
Length = 259
Score = 84.2 bits (199), Expect = 2e-15
Identities = 56/151 (37%), Positives = 76/151 (50%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H+A+ E ++ + T+ITQ++DGLH RAG++ LIEL+G+L + RC + + D
Sbjct: 85 HYALVDLEQHYPA---FTLITQSIDGLHWRAGSRDLIELNGSLRRCRCFESGHIAFAWDD 141
Query: 205 PICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMS 384
+IP P C CG+LLRP +V FGE L H L A A+
Sbjct: 142 D---------------GEIP----PRC--VQCGSLLRPDVVMFGEGLPHHELRRARQAVE 180
Query: 385 TCDVCLVVGTSSVVYPAAMFAPQAASRGAIV 477
CDV L VGT + P A F A GA V
Sbjct: 181 QCDVFLCVGTVGAIEPVASFPFVARRHGAFV 211
>UniRef50_A7SK95 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 323
Score = 82.2 bits (194), Expect = 9e-15
Identities = 56/185 (30%), Positives = 90/185 (48%), Gaps = 12/185 (6%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H+A+AK E GS + +TQNVD LH +AG+K +IELHG ++ C C ++
Sbjct: 131 HYALAKLE-TLGSVHSL--VTQNVDALHTKAGSKNVIELHGCSHRVICLGCNQITARTAL 187
Query: 205 PICTCK*RSPRF*YGGFDIP----------VK--LLPHCKKAHCGALLRPHIVWFGESLE 348
+ G P VK +P CK CG +L+P +V+FG+S+
Sbjct: 188 QKRMIEFNPDWHAVGQGQAPDGDTFLTSEAVKDFKVPPCKA--CGGILKPEVVFFGDSVP 245
Query: 349 HDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFY 528
I+ A ++ D ++G++ VY + FA +A+ +G +A NI T A+ ++
Sbjct: 246 KQIVNIAYDRLAESDALWIIGSTVEVYSSYRFATEASKQGKPIAILNIGKTRADKLASLK 305
Query: 529 FEGPC 543
G C
Sbjct: 306 VSGVC 310
>UniRef50_Q9WYW0 Cluster: NAD-dependent deacetylase; n=4;
Thermotoga|Rep: NAD-dependent deacetylase - Thermotoga
maritima
Length = 246
Score = 81.8 bits (193), Expect = 1e-14
Identities = 58/167 (34%), Positives = 84/167 (50%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE 183
+A H +AK E+ + VITQN+D LH RAG+K++IELHGN+ + C +C++
Sbjct: 73 QAKPNLAHVLLAKLEEKGLIE---AVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEK 129
Query: 184 VLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILE 363
D K S D+P+ C C +L+RP+IV+FGE+L D L
Sbjct: 130 KYTVED---VIKKLESS-------DVPL-----CD--DCNSLIRPNIVFFGENLPQDALR 172
Query: 364 AAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
A S + +V+G+S VVYPAA G + N+ TP
Sbjct: 173 EAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETP 219
>UniRef50_Q9I4L0 Cluster: NAD-dependent deacetylase 1; n=10;
Bacteria|Rep: NAD-dependent deacetylase 1 - Pseudomonas
aeruginosa
Length = 250
Score = 81.4 bits (192), Expect = 2e-14
Identities = 53/140 (37%), Positives = 67/140 (47%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
++TQNVD LH RAG++ ++ LHG+L+ RC C + P R
Sbjct: 95 LVTQNVDDLHERAGSRDVLHLHGSLHAPRCATCAAAY-RDALPDSVEPEEGRRI------ 147
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
P P C CG +RP +VWFGE+L L A A CD+ L VGTS VV PAA
Sbjct: 148 EP----PRCPA--CGGQVRPGVVWFGEALPEAALREAFAAACECDLLLSVGTSGVVQPAA 201
Query: 439 MFAPQAASRGAIVAEFNIEP 498
A GA V N +P
Sbjct: 202 RIPGLALEHGASVVHVNPQP 221
>UniRef50_A7B9E8 Cluster: Putative uncharacterized protein; n=1;
Actinomyces odontolyticus ATCC 17982|Rep: Putative
uncharacterized protein - Actinomyces odontolyticus ATCC
17982
Length = 251
Score = 81.0 bits (191), Expect = 2e-14
Identities = 53/138 (38%), Positives = 71/138 (51%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H A+A E + + VITQN+DGLH RAG++ + ELHGN + CT C V DS
Sbjct: 83 HRALASLE---AAGRLDAVITQNIDGLHQRAGSRAVWELHGNWERLVCTSCGAVASLGDS 139
Query: 205 PICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMS 384
+ +P C C + +RP IV +GESL+ ++EAA A+S
Sbjct: 140 ----------------VRVDGDPVPACPS--CASQMRPDIVMYGESLDQGVIEAAVSAIS 181
Query: 385 TCDVCLVVGTSSVVYPAA 438
+V GTS VVYPAA
Sbjct: 182 RASTLIVAGTSLVVYPAA 199
>UniRef50_A6DC77 Cluster: Silent information regulator protein Sir2;
n=1; Caminibacter mediatlanticus TB-2|Rep: Silent
information regulator protein Sir2 - Caminibacter
mediatlanticus TB-2
Length = 243
Score = 81.0 bits (191), Expect = 2e-14
Identities = 51/160 (31%), Positives = 77/160 (48%), Gaps = 1/160 (0%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H+ +A E G K VITQN+D LH +AG+K +IE HG K C CK
Sbjct: 82 HYFLADLEKK-GILK--AVITQNIDNLHQKAGSKNVIEFHGTANKLECLNCKSK------ 132
Query: 205 PICTCK*RSPRF*YGGFDIPVKLLPH-CKKAHCGALLRPHIVWFGESLEHDILEAAEHAM 381
+ F++P++ +P C K C +L+P V+F E + + E + +
Sbjct: 133 -------------FNSFEVPLENIPPLCPK--CNGVLKPDFVFFKEPIPKEAFEKSIYYS 177
Query: 382 STCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
D+ LV+GT+ + PA+ A GA + E NIEP+
Sbjct: 178 QNADIMLVIGTTGEIMPASELPLLAKQNGAAIIEINIEPS 217
>UniRef50_Q88BY5 Cluster: NAD-dependent deacetylase; n=9;
Bacteria|Rep: NAD-dependent deacetylase - Pseudomonas
putida (strain KT2440)
Length = 262
Score = 80.6 bits (190), Expect = 3e-14
Identities = 55/180 (30%), Positives = 83/180 (46%)
Frame = +1
Query: 1 AKANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCK 180
++A + H +I + D + ++V+TQN+D LH RAG+ ++ LHG+L +C C
Sbjct: 75 SQAKPNSAHLSIPQLAD---AGWDVSVVTQNIDDLHERAGSSPVVHLHGSLMDVKCFGCH 131
Query: 181 EVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDIL 360
+ + P G P P C + C LRP +VWF E+L +
Sbjct: 132 RPAELSPDQLAV-----PL--EGQLIEP----PRCTR--CNGRLRPGVVWFRENLPDNAW 178
Query: 361 EAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEGP 540
+A + CD+ + VGTS VV PAA A + GA V N+E + EGP
Sbjct: 179 RSAVRLVRACDLLVSVGTSGVVMPAAGIPDMALAVGATVIHVNLEDVGMDGADEIMLEGP 238
>UniRef50_A1I9S7 Cluster: NAD-dependent deacetylase; n=1; Candidatus
Desulfococcus oleovorans Hxd3|Rep: NAD-dependent
deacetylase - Candidatus Desulfococcus oleovorans Hxd3
Length = 273
Score = 80.2 bits (189), Expect = 4e-14
Identities = 52/138 (37%), Positives = 72/138 (52%), Gaps = 1/138 (0%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNN-DSPICTCK*RSPRF*YGGF 255
VITQN+D LH AG ++IE+HGN ++ RC KC+ + + I K R
Sbjct: 104 VITQNIDNLHQEAGNTQVIEMHGNGFRFRCLKCRSRRSHERHALIGRVKERLSTLPDFSP 163
Query: 256 DIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPA 435
+P C CG+ +RP +V FGE++ +E A A +CDV L +GTS VV PA
Sbjct: 164 ASIFAAMPDCDL--CGSGMRPDVVMFGETVME--VENAFAAARSCDVMLALGTSGVVTPA 219
Query: 436 AMFAPQAASRGAIVAEFN 489
A +A + GA V N
Sbjct: 220 AQIPAEAKASGAKVIVIN 237
>UniRef50_Q5YR82 Cluster: Putative Sir2 family regulator; n=1;
Nocardia farcinica|Rep: Putative Sir2 family regulator -
Nocardia farcinica
Length = 248
Score = 79.4 bits (187), Expect = 7e-14
Identities = 55/174 (31%), Positives = 83/174 (47%), Gaps = 2/174 (1%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKC 177
+A AGH A+ E + + +T+ITQNVD LH RAG+ +R++E+HGN+++ C C
Sbjct: 72 QAEPNAGHLALVDLER---AGRAVTIITQNVDRLHQRAGSSPQRVVEIHGNMFEVVCVGC 128
Query: 178 KEVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDI 357
+ + + P P C + CG +L+ + FG+ L+
Sbjct: 129 -DYETGMADVLARVEAGEPD-------------PACPE--CGGILKAATIMFGQQLDQRT 172
Query: 358 LEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLIS 519
+ A T D+ L VGTS V PAA A GA + N EPTP + I+
Sbjct: 173 MTKAALTAQTSDIFLAVGTSLQVEPAASMCALAVDAGADLVIVNAEPTPYDSIA 226
>UniRef50_Q67KQ0 Cluster: NAD-dependent deacetylase; n=1;
Symbiobacterium thermophilum|Rep: NAD-dependent
deacetylase - Symbiobacterium thermophilum
Length = 251
Score = 79.0 bits (186), Expect = 9e-14
Identities = 54/144 (37%), Positives = 74/144 (51%), Gaps = 3/144 (2%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
+ITQNVDGLH AG+ +IELHG+L + +C +C RF D
Sbjct: 98 LITQNVDGLHQAAGSPDVIELHGSLRECQCLRCGR-----------------RFPSRLID 140
Query: 259 IPVKL---LPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVY 429
+ V+ +P C + CG +L+P +V F E+L D +EAA A D+ LVVG+S V
Sbjct: 141 VEVETEADIPRCPE--CGGVLKPGVVLFEEALPADAIEAAIEAAMKADLFLVVGSSLEVG 198
Query: 430 PAAMFAPQAASRGAIVAEFNIEPT 501
PA A G +A FN+ PT
Sbjct: 199 PANQLPVLAVQHGGRLAIFNLTPT 222
>UniRef50_UPI000049979A Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 319
Score = 78.6 bits (185), Expect = 1e-13
Identities = 59/158 (37%), Positives = 80/158 (50%)
Frame = +1
Query: 16 TAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVN 195
T HFA+ K E+ G ++I ITQNVD LH AG++++IELHG +C KC
Sbjct: 92 TKAHFALRKLEEI-GKLEEI--ITQNVDNLHQLAGSRKVIELHGTGKICQCIKCG---YQ 145
Query: 196 NDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEH 375
++ + K G IP +P C K CG L++ +V FGE LE + E A
Sbjct: 146 GNADVVLPK---------GL-IPWIDIPRCPK--CGGLIKLDVVLFGEQLEKEKFEKAFE 193
Query: 376 AMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFN 489
S+ DV LV+G+S V PA +A A VA N
Sbjct: 194 VASSSDVFLVIGSSLEVMPANALPRKAKMNSATVAYIN 231
>UniRef50_Q2LSF2 Cluster: Sir2 family of NAD+-dependent deacetylase;
n=2; Syntrophus aciditrophicus SB|Rep: Sir2 family of
NAD+-dependent deacetylase - Syntrophus aciditrophicus
(strain SB)
Length = 271
Score = 78.2 bits (184), Expect = 2e-13
Identities = 56/170 (32%), Positives = 80/170 (47%), Gaps = 2/170 (1%)
Frame = +1
Query: 1 AKANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTK 174
A+A H A+A+ E K VITQN+D LH +AG +++ ELHGN+ +C
Sbjct: 86 AEAQPNRAHLAVAELEK---IGKLNCVITQNIDNLHQKAGNAPEKVYELHGNMRWLKCLS 142
Query: 175 CKEVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHD 354
C + + + T F P C K C L++P +++FGE+L
Sbjct: 143 CGDRVSVPEMFRETALQEMDGF------------PFCAK--CQGLMKPDVIFFGEALPEK 188
Query: 355 ILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
L A CD+ LV+G+S VVYPAA A GA + N + TP
Sbjct: 189 TLRDATWQARNCDLLLVIGSSLVVYPAAYMPMYAKDAGARLVIINRDETP 238
>UniRef50_A6P1S7 Cluster: Putative uncharacterized protein; n=2;
Bacteria|Rep: Putative uncharacterized protein -
Bacteroides capillosus ATCC 29799
Length = 262
Score = 78.2 bits (184), Expect = 2e-13
Identities = 53/166 (31%), Positives = 80/166 (48%)
Frame = +1
Query: 7 ANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEV 186
A A H +A+ E + K ++TQN+DGLH +AG+K ++ELHG++ + C KC +
Sbjct: 99 AQPNAAHKKLAELEQ---AGKLTAMVTQNIDGLHQKAGSKNVLELHGSVLRNYCEKCGKF 155
Query: 187 LVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEA 366
D + +P C K CG ++P +V + E+L+ IL A
Sbjct: 156 FSLEDV------------------MASSGVPRCDK--CGGRVKPDVVLYEEALDQQILTA 195
Query: 367 AEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
A A+ D+ ++ GTS VYPAA RG + N PTP
Sbjct: 196 ALEAIQKADMLIIGGTSLAVYPAASLVNY--YRGNKLVLINKSPTP 239
>UniRef50_Q974M6 Cluster: NAD-dependent deacetylase; n=8;
Thermoprotei|Rep: NAD-dependent deacetylase - Sulfolobus
tokodaii
Length = 250
Score = 77.8 bits (183), Expect = 2e-13
Identities = 60/165 (36%), Positives = 82/165 (49%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H+A+A+ E G + I ITQN+DGLH AG++ +IELHGN+ K C C L DS
Sbjct: 80 HYALAELE-KMGLIRAI--ITQNIDGLHQLAGSRNVIELHGNMRKCYCVNC---LKTYDS 133
Query: 205 PICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMS 384
K I + LP K CG ++RP +V FGE + ++I A E A
Sbjct: 134 DTVLDK------------IDKEGLP--PKCECGGVIRPDVVLFGEPV-YNISSALEIARE 178
Query: 385 TCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLIS 519
D+ L +G+S VYPA M G + N E TP + I+
Sbjct: 179 -ADLVLAIGSSLTVYPANMIPLTVKEMGGKLIILNAEETPLDNIA 222
>UniRef50_Q8ZU41 Cluster: NAD-dependent deacetylase 1; n=3;
Pyrobaculum|Rep: NAD-dependent deacetylase 1 -
Pyrobaculum aerophilum
Length = 254
Score = 77.4 bits (182), Expect = 3e-13
Identities = 57/171 (33%), Positives = 77/171 (45%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H+A+A+ E K VITQNVD LH AG+K +IELHG L CT C ++
Sbjct: 87 HYALAEMER---LGKLCAVITQNVDRLHQAAGSKNVIELHGALEYAVCTNCGSKYALAEA 143
Query: 205 PICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMS 384
K R P C K CG +++P +V+FGE L D L A
Sbjct: 144 ----LKWRKSG------------APRCPK--CGGVIKPDVVFFGEPLPQDALREAFMLAE 185
Query: 385 TCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEG 537
+V + +GTS VYPA A RGA + N + T + + + G
Sbjct: 186 MAEVFMAIGTSLAVYPANQLPLVAKKRGAKLVIINADETYYDFFADYIIRG 236
>UniRef50_UPI000049971A Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 285
Score = 77.0 bits (181), Expect = 3e-13
Identities = 58/171 (33%), Positives = 83/171 (48%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H A+A+ E G K T++TQNVDGLH +AG+K ++E+HG+ C C + + D
Sbjct: 101 HEALAELE-KIGVVK--TIVTQNVDGLHQQAGSKNVVEMHGSGRACYCIDC-DYISRADD 156
Query: 205 PICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMS 384
I + P P + +P C K CG LL+ +V FGE L+ + A +
Sbjct: 157 DIWSKP--VP---------PSQCIPRCPK--CGGLLKLDVVLFGEKLDRVTYDEVVEAST 203
Query: 385 TCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEG 537
D LV+GTS V P + +A GA VA N TP + + F G
Sbjct: 204 KTDFLLVIGTSLQVAPCNIIPFRAKHCGAQVAFINCSKTPMDEYADFVVRG 254
>UniRef50_Q6BVM7 Cluster: Similar to CA4170|IPF7784 Candida
albicans; n=2; Saccharomycetaceae|Rep: Similar to
CA4170|IPF7784 Candida albicans - Debaryomyces hansenii
(Yeast) (Torulaspora hansenii)
Length = 301
Score = 77.0 bits (181), Expect = 3e-13
Identities = 65/194 (33%), Positives = 88/194 (45%), Gaps = 29/194 (14%)
Frame = +1
Query: 1 AKANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAG--TKRLIELHGNLYKTRCTK 174
+KA GH A+AK S + ITQNVDGL RAG ++L E+HG+L+ RCT
Sbjct: 75 SKAKPNKGHLALAKLSKL--SNIEFMTITQNVDGLLIRAGHPKEKLHEIHGSLFDLRCTS 132
Query: 175 --CKEVLVNNDSPICTCK*RSPRF*YGGFD------------------IPVKLLP----- 279
C V +N T F Y PVK +P
Sbjct: 133 FMCNYVDHDNFKNPLTKALADTEFEYDKSGRKRKIIDETEVNKLSPQFAPVKQIPEEELP 192
Query: 280 HCKKAHCGALLRPHIVWFGESLEHDILEAAEH--AMSTCDVCLVVGTSSVVYPAAMFAPQ 453
C G+LLRP +VWFGESL ++ ++ + D+ LV+GTS VYPA + +
Sbjct: 193 QCPVCEDGSLLRPGVVWFGESLPLQTIDKIDNFIELDKIDLILVIGTSGTVYPANSYVDR 252
Query: 454 AASRGAIVAEFNIE 495
+G VA FN +
Sbjct: 253 IKLKGGKVAIFNTD 266
>UniRef50_Q97MB4 Cluster: NAD-dependent deacetylase; n=7;
Bacteria|Rep: NAD-dependent deacetylase - Clostridium
acetobutylicum
Length = 245
Score = 75.8 bits (178), Expect = 8e-13
Identities = 49/144 (34%), Positives = 73/144 (50%)
Frame = +1
Query: 7 ANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEV 186
A A H+++AK E+ G K I +TQN+DGLH AG+K + ELHG++++ C C
Sbjct: 83 AKPNAAHYSLAKIEEQ-GKLKAI--VTQNIDGLHQLAGSKNVYELHGSIHRNYCMDC--- 136
Query: 187 LVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEA 366
F +P C K CG +++P +V + E L+ I++
Sbjct: 137 --------------GKSFDLEYVIKSETTIPKCDK--CGGIVKPDVVLYEEGLDDSIIQN 180
Query: 367 AEHAMSTCDVCLVVGTSSVVYPAA 438
+ A+S D +V GTS VVYPAA
Sbjct: 181 SVKAISEADTLIVGGTSLVVYPAA 204
>UniRef50_Q89EA6 Cluster: NAD-dependent deacetylase 2; n=9;
Proteobacteria|Rep: NAD-dependent deacetylase 2 -
Bradyrhizobium japonicum
Length = 273
Score = 75.8 bits (178), Expect = 8e-13
Identities = 55/185 (29%), Positives = 86/185 (46%), Gaps = 12/185 (6%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H A+A+ E N ++TQNVD LH AG +++I+LHG L RC C ++
Sbjct: 86 HHALARLEANGRCGM---LLTQNVDRLHQSAGHRQVIDLHGRLDLVRCMGCGAKTPRSEF 142
Query: 205 PICTCK*RSPRF*YGGFDIP---VKL---------LPHCKKAHCGALLRPHIVWFGESLE 348
+ + D P L +P C+ CG +L+P +V+FGE++
Sbjct: 143 QDTLGRANAEWLALDASDAPDGDADLEHADFSSFKVPACEA--CGGILKPDVVFFGENVP 200
Query: 349 HDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFY 528
D++ A+ +S D L+VG+S +VY F AA R +A N+ T A+ +
Sbjct: 201 RDVVATAQDHLSQADAMLIVGSSLMVYSGFRFVQAAAQRQIPIAAVNLGRTRADDLLTLK 260
Query: 529 FEGPC 543
E C
Sbjct: 261 VEERC 265
>UniRef50_UPI0000519F58 Cluster: PREDICTED: similar to Sirt4
CG3187-PC, isoform C isoform 2; n=2; Endopterygota|Rep:
PREDICTED: similar to Sirt4 CG3187-PC, isoform C isoform
2 - Apis mellifera
Length = 302
Score = 74.9 bits (176), Expect = 1e-12
Identities = 49/168 (29%), Positives = 86/168 (51%), Gaps = 13/168 (7%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE--------VLVNNDSPICTCK*RSP 234
+ITQNVD LH +AG+K++IELHG ++ C C E + + +P T +
Sbjct: 126 IITQNVDNLHTKAGSKKVIELHGTAFRVMCLNCNERICRYYLQDIFDRINPNMTVTSQMI 185
Query: 235 RF*YGGFDIPVK-----LLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVC 399
R G ++ + +P C+K C +L+P I++FG+++ I+E ++ + D
Sbjct: 186 R-PDGDVELTQEQVEEFKVPICEK--CDGILKPDIIFFGDNVPRKIVENIKYNIEHSDSL 242
Query: 400 LVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEGPC 543
L++GT+ + + A QA + G +A NI T + ++ EG C
Sbjct: 243 LIIGTTLTTFSSYRIALQANNIGKPIAILNIGKTRVDNLAKIKVEGRC 290
>UniRef50_A1HU63 Cluster: Silent information regulator protein Sir2;
n=1; Thermosinus carboxydivorans Nor1|Rep: Silent
information regulator protein Sir2 - Thermosinus
carboxydivorans Nor1
Length = 243
Score = 74.9 bits (176), Expect = 1e-12
Identities = 51/141 (36%), Positives = 74/141 (52%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
++TQN+DGLH+RAG + ELHGNLY+ C +C+ N P+ R
Sbjct: 97 LMTQNIDGLHSRAGAGVVWELHGNLYRGYCMECRTEYDMN-GPLAAFLQRG--------Q 147
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
IP A CGA+LRP +V+FG+ L + AE S D+ LV+G++ V PA
Sbjct: 148 IPT-------SACCGAVLRPDVVFFGDKLPAETWRHAERLASASDLMLVIGSTLEVAPAC 200
Query: 439 MFAPQAASRGAIVAEFNIEPT 501
+ P+ + AI+ N+ PT
Sbjct: 201 -YLPELSREIAII---NLGPT 217
>UniRef50_Q5L014 Cluster: NAD-dependent deacetylase 1; n=7;
Bacillaceae|Rep: NAD-dependent deacetylase 1 -
Geobacillus kaustophilus
Length = 242
Score = 74.9 bits (176), Expect = 1e-12
Identities = 56/160 (35%), Positives = 72/160 (45%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND 201
GH +A +E Q T++TQNVDG H AG++R+IELHG+L C +C E
Sbjct: 78 GHRLLADWERRGIVQ---TIVTQNVDGFHQEAGSRRVIELHGSLRTVHCQRCGE------ 128
Query: 202 SPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAM 381
P F Y L CG +LRP +V FGE L + A A
Sbjct: 129 --------SKPSFVY---------LHGVLTCECGGVLRPSVVLFGEPLPEKAITEAWEAA 171
Query: 382 STCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
D+ LV+G+S V PA A GA + N EPT
Sbjct: 172 QQADLFLVLGSSLQVSPANQLPLVAKRNGAKLVIINWEPT 211
>UniRef50_A7H7B6 Cluster: Silent information regulator protein Sir2;
n=2; Anaeromyxobacter|Rep: Silent information regulator
protein Sir2 - Anaeromyxobacter sp. Fw109-5
Length = 270
Score = 74.5 bits (175), Expect = 2e-12
Identities = 55/171 (32%), Positives = 82/171 (47%), Gaps = 5/171 (2%)
Frame = +1
Query: 7 ANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTK-CKE 183
A AGH A+ E G ++ T++TQN+DGLH RAG++R++ +HG+ RC C
Sbjct: 82 ARPNAGHAALVALERALG--ERFTLVTQNIDGLHRRAGSERVLCIHGDAAYVRCADGCGT 139
Query: 184 VLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKA--HCGALLRPHIVWFGESLE--H 351
L++ P F G D P+ + A CG LRPH++WF E + +
Sbjct: 140 GLLD-----------LPLFPQRGKDDPLTDADRARLACPSCGGWLRPHVLWFDEYYDEVN 188
Query: 352 DILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
+E+A A + ++ LVVGTS A R A + + N E P
Sbjct: 189 YRMESALRAAAEAELLLVVGTSGATNLPMQIGRLAFERQAALVDVNPEVNP 239
>UniRef50_A1ZZG3 Cluster: NAD-dependent deacetylase; n=35;
Bacteria|Rep: NAD-dependent deacetylase - Microscilla
marina ATCC 23134
Length = 245
Score = 74.5 bits (175), Expect = 2e-12
Identities = 48/139 (34%), Positives = 73/139 (52%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND 201
GH A+A+ E + ++ +ITQN+D LH +AG+ ++ LHG L K R T
Sbjct: 83 GHLALARLEAKY----EVVIITQNIDDLHEKAGSSNVLHLHGELGKARST---------- 128
Query: 202 SPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAM 381
+P Y + P+ + C+K G+ LRPHIVWFGE++ ++ A
Sbjct: 129 --------TNPELVYDWGNKPINIGDKCEK---GSQLRPHIVWFGEAV--PMMTVAIQET 175
Query: 382 STCDVCLVVGTSSVVYPAA 438
+ ++ +VVGTS VYPAA
Sbjct: 176 HSANLFIVVGTSLAVYPAA 194
>UniRef50_A0NQ49 Cluster: Silent information regulator protein Sir2;
n=1; Stappia aggregata IAM 12614|Rep: Silent information
regulator protein Sir2 - Stappia aggregata IAM 12614
Length = 260
Score = 74.5 bits (175), Expect = 2e-12
Identities = 57/169 (33%), Positives = 77/169 (45%), Gaps = 2/169 (1%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAG--TKRLIELHGNLYKTRCTKC 177
KA A HFA+ S K + +ITQNVDGLH RAG L+E+HGN C C
Sbjct: 90 KAEPNAAHFALTTLAR---SGKLVCLITQNVDGLHQRAGFPDDLLVEIHGNSTFASCLSC 146
Query: 178 KEVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDI 357
+ + P G P C + C LL+ ++ FG+ +
Sbjct: 147 --------GARAELEAQKPAVDAGES-------PRCSQ--CDGLLKAAVISFGQQMPERE 189
Query: 358 LEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
L+ A A S CD+ LV+G+S VV+PAA A GA + N + TP
Sbjct: 190 LQRAAEAASACDLFLVLGSSLVVHPAAQLPAVAVQSGAELVILNGQETP 238
>UniRef50_Q046W9 Cluster: NAD-dependent protein deacetylase, SIR2
family; n=6; Lactobacillus|Rep: NAD-dependent protein
deacetylase, SIR2 family - Lactobacillus gasseri (strain
ATCC 33323 / DSM 20243)
Length = 237
Score = 74.1 bits (174), Expect = 2e-12
Identities = 53/153 (34%), Positives = 76/153 (49%), Gaps = 1/153 (0%)
Frame = +1
Query: 67 KKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*Y 246
K T+ITQNVDGL +AG K +IE HGNLY CTKC E +
Sbjct: 95 KNGTLITQNVDGLDKKAGNKHVIEFHGNLYNIFCTKCHEKI------------------- 135
Query: 247 GGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVV 426
++ K H K H ++RP IV +GE + +L + A+ D+ ++ GTS VV
Sbjct: 136 -SYEEYKKSYLHAKD-H--GIIRPGIVLYGEPINEMVLTDSVKAIQNSDLVIIAGTSFVV 191
Query: 427 YP-AAMFAPQAASRGAIVAEFNIEPTPANLISI 522
YP A + A + A+ V PTP ++++I
Sbjct: 192 YPFAQLLAYRQATAKVWVINNTPVPTPKDVLTI 224
>UniRef50_UPI00006CB0CC Cluster: transcriptional regulator, Sir2
family protein; n=1; Tetrahymena thermophila SB210|Rep:
transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 442
Score = 73.7 bits (173), Expect = 3e-12
Identities = 49/144 (34%), Positives = 72/144 (50%), Gaps = 2/144 (1%)
Frame = +1
Query: 76 TVITQNVDGLHARAGTKR--LIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YG 249
+VITQNVD LH ++G R + ELHGN+ RC KC V + R +G
Sbjct: 147 SVITQNVDNLHHQSGIPRKDIHELHGNIISERCEKCNYVHYRDFYT------RLKHLKWG 200
Query: 250 GFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVY 429
P C+K C L +V+FGES+ +I ++A+ + + D+C+VVGTS V
Sbjct: 201 D---PHNTGRICQKNGCDGQLHDTLVFFGESVLQNIKQSAQEQIESADLCIVVGTSLTVQ 257
Query: 430 PAAMFAPQAASRGAIVAEFNIEPT 501
AA + RG + N++ T
Sbjct: 258 SAARLVWISQQRGIPIVIINLQKT 281
>UniRef50_Q73KE1 Cluster: NAD-dependent deacetylase; n=1; Treponema
denticola|Rep: NAD-dependent deacetylase - Treponema
denticola
Length = 251
Score = 73.7 bits (173), Expect = 3e-12
Identities = 52/152 (34%), Positives = 72/152 (47%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
VITQN+D LH +AG+K +IE+HG+ C C ++ T K
Sbjct: 101 VITQNIDLLHQKAGSKNVIEVHGSPSVHYCINCSYTETFEETAK-TAK------------ 147
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
+P C K CG+ ++P I +FGE+L L AE S D LV+GTS +VYPAA
Sbjct: 148 --TGEVPRCPK--CGSPIKPAITFFGEALPQKALMKAETEASKSDFMLVLGTSLLVYPAA 203
Query: 439 MFAPQAASRGAIVAEFNIEPTPANLISIFYFE 534
G +A N +PT + + FE
Sbjct: 204 ALPAYTLRNGGKIAIVNNQPTQFDSYTDLLFE 235
>UniRef50_A1HLU5 Cluster: Silent information regulator protein Sir2;
n=1; Thermosinus carboxydivorans Nor1|Rep: Silent
information regulator protein Sir2 - Thermosinus
carboxydivorans Nor1
Length = 261
Score = 73.3 bits (172), Expect = 4e-12
Identities = 57/167 (34%), Positives = 79/167 (47%), Gaps = 6/167 (3%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKC------KE 183
GH A+A+ G K+ +TQNVDGLH RAG++ + ELHG L C KC ++
Sbjct: 82 GHLALAELAQA-GFVTKL--VTQNVDGLHQRAGSQGVAELHGTLRTVSCIKCGSQYDSRQ 138
Query: 184 VLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILE 363
+L +ND+ K + R+ +G C C LRP +V FGESL
Sbjct: 139 MLPHNDTWEEDYK--AGRYRHGS---------ECYCPRCQGQLRPDVVLFGESLPDTAWN 187
Query: 364 AAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
A D +V+G+S VV PA A +GA + N + TP
Sbjct: 188 EAVRWSRKADFFVVIGSSLVVSPANYLPQLAVEQGAKLLIINSDSTP 234
>UniRef50_A6PTK3 Cluster: Silent information regulator protein Sir2;
n=1; Victivallis vadensis ATCC BAA-548|Rep: Silent
information regulator protein Sir2 - Victivallis
vadensis ATCC BAA-548
Length = 248
Score = 72.9 bits (171), Expect = 6e-12
Identities = 46/142 (32%), Positives = 71/142 (50%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
V TQN+D LH +AG++ + ELHG+ + C KC++ +F Y
Sbjct: 99 VYTQNIDLLHQQAGSRHVYELHGSPARHHCLKCRK-----------------QFGYAEI- 140
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
P+ L + CG L++P IV++GE+L+ +L A M ++ LV+G+S V PAA
Sbjct: 141 APLVLAGKVPRCGCGGLVKPDIVFYGENLDEALLNQAFADMEKAELVLVLGSSLTVQPAA 200
Query: 439 MFAPQAASRGAIVAEFNIEPTP 504
A G + N +PTP
Sbjct: 201 SLPMAANYGGGKIVIVNAQPTP 222
>UniRef50_Q7WLE5 Cluster: NAD-dependent deacetylase; n=47;
Bacteria|Rep: NAD-dependent deacetylase - Bordetella
bronchiseptica (Alcaligenes bronchisepticus)
Length = 274
Score = 72.5 bits (170), Expect = 7e-12
Identities = 54/192 (28%), Positives = 90/192 (46%), Gaps = 12/192 (6%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCK- 180
+A A H A+A+ Q + ++TQNVD LH AG + +++LHG L + RC +C
Sbjct: 79 QARPNAAHHALARLAQR--GQVDL-LVTQNVDRLHQAAGGREVLDLHGRLDEVRCMQCDW 135
Query: 181 ---------EVLVNNDSPICTCK*RSPR--F*YGGFDIPVKLLPHCKKAHCGALLRPHIV 327
+ + N +P G D ++P C + CG +++P +V
Sbjct: 136 RGPRGPWQHTLELANPQWAALQAGAAPDGDADLEGQDFSRFVVPSCPR--CGGIVKPDVV 193
Query: 328 WFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPA 507
+FGE++ + ++ A A+ D LVVG+S ++Y F AA G +A N+ T A
Sbjct: 194 FFGETVPRERVQRAYAALEHADAVLVVGSSLMLYSGYRFVQAAARAGLPIAAINLGRTRA 253
Query: 508 NLISIFYFEGPC 543
+ + PC
Sbjct: 254 DDMLALKVSRPC 265
>UniRef50_UPI00015B4FA0 Cluster: PREDICTED: similar to chromatin
regulatory protein sir2; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to chromatin regulatory protein sir2 -
Nasonia vitripennis
Length = 736
Score = 72.1 bits (169), Expect = 1e-11
Identities = 52/170 (30%), Positives = 79/170 (46%), Gaps = 15/170 (8%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKC---------KEVLVN-NDSPICTCK*R 228
VITQNVD LH +AG+K ++ELHG Y+ C C +EVL N +C+
Sbjct: 560 VITQNVDNLHIKAGSKNVVELHGTGYRVVCLSCNNKIDRFVFQEVLNKLNPDMKASCEAI 619
Query: 229 SPRF*YGGFDIPVK-----LLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCD 393
P G D+ +P C K CG +++P IV+FG+++ ++E ++ + D
Sbjct: 620 RPD---GDVDLSQDQIDDFKIPPCSK--CGGIMKPDIVFFGDNVPKQVVERVQNEVEEAD 674
Query: 394 VCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEGPC 543
LV+GTS + QA +A NI T + + G C
Sbjct: 675 SLLVLGTSLTTFSGYRIVLQAVEAVKPIAILNIGDTRGDEHAQIRVHGRC 724
>UniRef50_A1ZHW6 Cluster: NAD-dependent deacetylase; n=2;
Microscilla marina ATCC 23134|Rep: NAD-dependent
deacetylase - Microscilla marina ATCC 23134
Length = 279
Score = 72.1 bits (169), Expect = 1e-11
Identities = 50/138 (36%), Positives = 72/138 (52%), Gaps = 6/138 (4%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTK--CKEVL 189
GH+A+A+ E G K+ T++TQNVDGLH RAG+ K + +HG+L RC+K C L
Sbjct: 89 GHYAVAEMEKILGG-KRFTLVTQNVDGLHFRAGSTFKNTLLIHGDLTHVRCSKDSCDTEL 147
Query: 190 VNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGE--SLEHDILE 363
+ I S I ++ + CGAL RPH++WF E + ++ E
Sbjct: 148 LPFPEGIAPKTRESA--------ISLEEWERLRCPSCGALTRPHVLWFDEYYNEKYYKYE 199
Query: 364 AAEHAMSTCDVCLVVGTS 417
A H D+ +VVGTS
Sbjct: 200 TALHKNREADLLIVVGTS 217
>UniRef50_A6FYM4 Cluster: Sir2 family protein; n=1; Plesiocystis
pacifica SIR-1|Rep: Sir2 family protein - Plesiocystis
pacifica SIR-1
Length = 297
Score = 71.3 bits (167), Expect = 2e-11
Identities = 52/177 (29%), Positives = 85/177 (48%), Gaps = 10/177 (5%)
Frame = +1
Query: 1 AKANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCK 180
++A A H +A+ E + +ITQNVD LH +AG++ ++ELHG L + RC C
Sbjct: 93 SRARPNAAHRVLAQLE---AAGVLSGLITQNVDRLHHQAGSRAVVELHGALAEVRCLSC- 148
Query: 181 EVLVNNDSPICTCK*RSPRF*Y--------GGFDI--PVKLLPHCKKAHCGALLRPHIVW 330
+ + D+ +P + + G ++ PV CG LL+P++V+
Sbjct: 149 QTIEGRDALQDRLLGLNPSWRHLDAAMAPDGDAELEDPVDRFQVADCQACGGLLKPNVVF 208
Query: 331 FGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
FGE + ++ A + +V V G+S V+ F +A +RG VA N PT
Sbjct: 209 FGEQVPQATVDQAYAMVEDAEVLAVFGSSLAVFSGLRFVKRAKARGIPVAIINAGPT 265
>UniRef50_A4M603 Cluster: Silent information regulator protein Sir2;
n=1; Petrotoga mobilis SJ95|Rep: Silent information
regulator protein Sir2 - Petrotoga mobilis SJ95
Length = 256
Score = 71.3 bits (167), Expect = 2e-11
Identities = 51/158 (32%), Positives = 83/158 (52%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE 183
KA T H + + E G K I +TQN+D LH +AG+K++ E+HG +K CTKCK
Sbjct: 79 KAEPTFTHKFLVQLE-KEGKLKGI--VTQNIDSLHQKAGSKKVYEIHGGCWKNYCTKCKR 135
Query: 184 VLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILE 363
+ I + +++P C +CG +++P IV+FGE +++ L
Sbjct: 136 KY--SQEEILE-------------KMNNEVVPKCD--NCGGVIKPDIVFFGEPVKY--LT 176
Query: 364 AAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIV 477
+E M ++ LV+G+S V PAAM + ++G I+
Sbjct: 177 ESEILMKNSELVLVLGSSLAVIPAAML--PSLTKGKII 212
>UniRef50_Q5V4Q5 Cluster: NAD-dependent deacetylase; n=2;
Halobacteriaceae|Rep: NAD-dependent deacetylase -
Haloarcula marismortui (Halobacterium marismortui)
Length = 260
Score = 71.3 bits (167), Expect = 2e-11
Identities = 54/163 (33%), Positives = 74/163 (45%), Gaps = 1/163 (0%)
Frame = +1
Query: 19 AGHFAIAKFE-DNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVN 195
A H A+A E D H V+TQN+DGLH AGT R++ELHG + C C
Sbjct: 94 AAHEALAALEADGHLD----AVLTQNIDGLHDAAGTDRVVELHGTHRRVVCDDCGH---R 146
Query: 196 NDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEH 375
D+ + + D+P P C CG + RP +V FGE + + A+
Sbjct: 147 RDAEVVFEQAAE------SSDLP----PRC---DCGGVYRPDVVLFGEPMPDVAMNEAQR 193
Query: 376 AMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
DV L VG+S V PA++ AA + + N E TP
Sbjct: 194 LARDSDVFLAVGSSLSVQPASLLPKIAAEGDSTLVVVNYEETP 236
>UniRef50_A3JEV2 Cluster: NAD-dependent deacetylase; n=2;
Marinobacter|Rep: NAD-dependent deacetylase -
Marinobacter sp. ELB17
Length = 300
Score = 70.9 bits (166), Expect = 2e-11
Identities = 56/185 (30%), Positives = 86/185 (46%), Gaps = 13/185 (7%)
Frame = +1
Query: 7 ANYTAGHFAIAKFED-NHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE 183
A+ A H I++ E NH S V+TQNVD LH +AGT+ + +LHG + C C +
Sbjct: 105 ASPNASHHHISQLEMLNHSS----LVVTQNVDRLHQKAGTQAVTDLHGRADEVLCMSC-D 159
Query: 184 VLVNNDSPICTCK*RSPRF*Y--------GGFDIPVKL----LPHCKKAHCGALLRPHIV 327
D C +P+F G D+ + L C CG +L+P +V
Sbjct: 160 YRCMRDEVHQRCAILNPQFSAFTADVAPDGDADLDINFADFQLADCPV--CGGILKPDVV 217
Query: 328 WFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPA 507
+FG+ + + AA A+ D LV+G+S +VY F A G +A N+ T A
Sbjct: 218 FFGDYVPKQRVNAALDALKASDGLLVIGSSLMVYSGFRFCRYAHEWGKPIATLNLGRTRA 277
Query: 508 NLISI 522
+++
Sbjct: 278 ESLAM 282
>UniRef50_Q8A3H9 Cluster: NAD-dependent deacetylase; n=3;
Bacteroides|Rep: NAD-dependent deacetylase - Bacteroides
thetaiotaomicron
Length = 234
Score = 70.9 bits (166), Expect = 2e-11
Identities = 60/163 (36%), Positives = 79/163 (48%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND 201
GH +A+ E N +TVITQNVD LH RAG+ ++ LHG L K C N
Sbjct: 68 GHELLAELEKNFN----VTVITQNVDNLHERAGSSHIVHLHGELTKV----CSSRDPYNP 119
Query: 202 SPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAM 381
I K P + VK+ KA G LRP IVWFGE++ +E A +
Sbjct: 120 HYIKELK---PE------EYEVKM---GDKAGDGTQLRPFIVWFGEAVPE--IETAVRYV 165
Query: 382 STCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPAN 510
D+ +++GTS VYPAA RGA V + I+P P +
Sbjct: 166 EKADIFVIIGTSLNVYPAAGLL-HYVPRGAEV--YLIDPKPVD 205
>UniRef50_Q5P3W1 Cluster: NAD-dependent deacetylase 2; n=4;
Proteobacteria|Rep: NAD-dependent deacetylase 2 -
Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum
(strain EbN1))
Length = 260
Score = 70.5 bits (165), Expect = 3e-11
Identities = 46/118 (38%), Positives = 62/118 (52%), Gaps = 1/118 (0%)
Frame = +1
Query: 73 ITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGG 252
+ V+TQNVDGLH AG++ LIE+HG++++ RCT+CK D Y G
Sbjct: 104 VWVLTQNVDGLHRAAGSRNLIEIHGSVHRLRCTECKHARSVPD--------------YSG 149
Query: 253 FDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMST-CDVCLVVGTSSV 423
IP P C CG +LRP IV FGE L L E + D+ + +GT+SV
Sbjct: 150 LRIP----PGCPV--CGGVLRPDIVLFGEMLPETGLRRLEALLDDGVDLVVSIGTTSV 201
>UniRef50_A6LP94 Cluster: Silent information regulator protein Sir2;
n=1; Thermosipho melanesiensis BI429|Rep: Silent
information regulator protein Sir2 - Thermosipho
melanesiensis BI429
Length = 234
Score = 70.5 bits (165), Expect = 3e-11
Identities = 57/166 (34%), Positives = 78/166 (46%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE 183
KANY H +A+ E+ + VITQN+D LH +AG++ +IELHGN C +C+
Sbjct: 71 KANYNMSHKLLAELEE---MGYLLGVITQNIDDLHNKAGSRNVIELHGNATHFYCEECER 127
Query: 184 VLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILE 363
IC+C GG L+RP IV+FGE + +DI
Sbjct: 128 KYSFPKEYICSC---------GG------------------LIRPDIVFFGEPV-NDIDR 159
Query: 364 AAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
E + + LV+GTS VYPA+ F RG I+ N E T
Sbjct: 160 VFE-LLDKAETLLVMGTSLQVYPASNFPVYVKERGGILIIVNREET 204
>UniRef50_Q1YSP9 Cluster: NAD-dependent deacetylase; n=1; gamma
proteobacterium HTCC2207|Rep: NAD-dependent deacetylase
- gamma proteobacterium HTCC2207
Length = 270
Score = 69.7 bits (163), Expect = 5e-11
Identities = 58/193 (30%), Positives = 89/193 (46%), Gaps = 12/193 (6%)
Frame = +1
Query: 1 AKANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCK 180
+ A H A+A E G+ ++TQNVDGLH RAG++++I+LHG + C CK
Sbjct: 71 SSARPNGAHSALASLE-KAGAVS--CLVTQNVDGLHQRAGSQKVIDLHGRVDSVSCLSCK 127
Query: 181 EVLVNNDSPICT-CK*RSPRF--*YGGF----DIPVKLLPHCKK-----AHCGALLRPHI 324
L +P+ T + +P F G D V L H +CG +L+P
Sbjct: 128 LRLPR--APLQTWLEANNPDFAKLAGAIAPDGDADVDNLDHSSMQVPDCENCGGVLKPDA 185
Query: 325 VWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
V+FG+S+ + AE M D +VVG+S V + F A+ +G + N T
Sbjct: 186 VFFGDSVPAQRVADAEQQMKDADGLVVVGSSLVAFSGYRFCLWASKQGKPIVIINDGKTR 245
Query: 505 ANLISIFYFEGPC 543
+ ++ G C
Sbjct: 246 GDELATAKVAGLC 258
>UniRef50_Q81NT6 Cluster: NAD-dependent deacetylase; n=11; Bacillus
cereus group|Rep: NAD-dependent deacetylase - Bacillus
anthracis
Length = 242
Score = 69.7 bits (163), Expect = 5e-11
Identities = 56/165 (33%), Positives = 79/165 (47%), Gaps = 5/165 (3%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND 201
GH +A+ E+ K IT++TQN+DGLH G+K +I+LHG L C KCK
Sbjct: 83 GHRFLAELEEQG---KDITILTQNIDGLHQVGGSKHVIDLHGTLQTAHCPKCKM------ 133
Query: 202 SPICTCK*RSPRF*YGGFDIPVKL---LPHCKKAHCGALLRPHIVWFGESLEHDILEAAE 372
G+D+ + +P C+K C +L P +V +G++L + A
Sbjct: 134 ----------------GYDLQYMIDHEVPRCEK--CNFILNPDVVLYGDTLPQ--YQNAI 173
Query: 373 HAMSTCDVCLVVGTSSVVYPAAMFAPQAASR--GAIVAEFNIEPT 501
+ DV +V+GTS V P A F PQ A R GA N E T
Sbjct: 174 KRLYETDVLIVMGTSLKVQPVASF-PQIAKREVGATTILVNEELT 217
>UniRef50_Q8CJM9 Cluster: NAD-dependent deacetylase 2; n=3;
Actinomycetales|Rep: NAD-dependent deacetylase 2 -
Streptomyces coelicolor
Length = 241
Score = 69.7 bits (163), Expect = 5e-11
Identities = 60/168 (35%), Positives = 74/168 (44%), Gaps = 2/168 (1%)
Frame = +1
Query: 7 ANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKCK 180
A A H A+A E G + V+TQNVDGLH AG ++++ELHG CT C
Sbjct: 68 AEPNAAHRAVADLE-RRGVP--VRVLTQNVDGLHQLAGVSARKVLELHGTARDCVCTGC- 123
Query: 181 EVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDIL 360
P+ R G D P L CG +L+ V FGE L+ +L
Sbjct: 124 ----GARGPMADVLARIE----AGEDDPPCL-------DCGGVLKTATVMFGERLDPVVL 168
Query: 361 EAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
A C V + VGTS V PAA A A GA + N EPTP
Sbjct: 169 GEAAAISKACQVFVAVGTSLQVEPAAGLARVAVEHGARLVVVNAEPTP 216
>UniRef50_A2QWZ2 Cluster: Function: human SIRT5 belongs to the
Sir2-like proteins precursor; n=1; Aspergillus
niger|Rep: Function: human SIRT5 belongs to the
Sir2-like proteins precursor - Aspergillus niger
Length = 258
Score = 69.3 bits (162), Expect = 7e-11
Identities = 37/81 (45%), Positives = 52/81 (64%), Gaps = 2/81 (2%)
Frame = +1
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMST--CDVCLVVGTSSVVYP 432
+P + LPHC + G LLRP +VWFGESL ++ + ++ D+ LVVGTSS VYP
Sbjct: 144 VPYEELPHCPECKDG-LLRPGVVWFGESLPSHTIDYVDEWLNKGKVDLILVVGTSSRVYP 202
Query: 433 AAMFAPQAASRGAIVAEFNIE 495
AA + +A S+GA VA N++
Sbjct: 203 AAGYVDKARSKGARVAVVNMD 223
>UniRef50_Q899G3 Cluster: NAD-dependent deacetylase; n=19; cellular
organisms|Rep: NAD-dependent deacetylase - Clostridium
tetani
Length = 247
Score = 69.3 bits (162), Expect = 7e-11
Identities = 51/138 (36%), Positives = 69/138 (50%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H A+AK E G K I ITQN+DGLH AG+K +IELHG + + C C + N
Sbjct: 86 HHALAKLE-KVGKLKAI--ITQNIDGLHQLAGSKNVIELHGGVGRNYCMDCNKFFDLN-- 140
Query: 205 PICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMS 384
I K +++P C CG +++P +V + E L D + A +
Sbjct: 141 YILNNK---------------EVVPKCDV--CGGIVKPDVVLYEEPLNMDNINNAVRYVE 183
Query: 385 TCDVCLVVGTSSVVYPAA 438
DV +V GTS VVYPAA
Sbjct: 184 NSDVLIVGGTSLVVYPAA 201
>UniRef50_Q12Y78 Cluster: Silent information regulator protein Sir2;
n=1; Methanococcoides burtonii DSM 6242|Rep: Silent
information regulator protein Sir2 - Methanococcoides
burtonii (strain DSM 6242)
Length = 245
Score = 68.9 bits (161), Expect = 9e-11
Identities = 51/160 (31%), Positives = 76/160 (47%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H ++K E+ G K I ITQN+D LH +AG+K +IE+HG+ + C C
Sbjct: 79 HSVLSKLEEK-GIIKAI--ITQNIDMLHQKAGSKNVIEVHGSPQEHVCLACG-------- 127
Query: 205 PICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMS 384
+ + Y + + P C + CG L++P IV++GE L D +E A S
Sbjct: 128 -------KKYSYEYIAELLKAEGFPLCNE--CGGLVKPDIVFYGEMLRQDTIEKAIQESS 178
Query: 385 TCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
D+ LV+G++ VV PAA G + N TP
Sbjct: 179 KADLMLVLGSTLVVQPAASLPLYTIENGGELVIVNDMKTP 218
>UniRef50_A7HL19 Cluster: Silent information regulator protein Sir2;
n=1; Fervidobacterium nodosum Rt17-B1|Rep: Silent
information regulator protein Sir2 - Fervidobacterium
nodosum Rt17-B1
Length = 244
Score = 68.5 bits (160), Expect = 1e-10
Identities = 46/141 (32%), Positives = 66/141 (46%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
VITQN+D LH +AG++++ E+HGN+ C KC + R+
Sbjct: 96 VITQNIDNLHKKAGSQKVAEIHGNVRTWSCLKCGK-----------------RYDLFNSQ 138
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
L+ + CG + +P IV+FGE L + AE+ DV + +GTS VVYPAA
Sbjct: 139 HKEFLIDRNFRCECGGVTKPDIVFFGEMLPLNEYSKAENWAKESDVFIAMGTSLVVYPAA 198
Query: 439 MFAPQAASRGAIVAEFNIEPT 501
A GA + N T
Sbjct: 199 QLPIYAKHSGAKLCIINKNET 219
>UniRef50_Q8CNF4 Cluster: NAD-dependent deacetylase; n=17;
Staphylococcus|Rep: NAD-dependent deacetylase -
Staphylococcus epidermidis (strain ATCC 12228)
Length = 246
Score = 68.5 bits (160), Expect = 1e-10
Identities = 52/160 (32%), Positives = 74/160 (46%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H IA+ E+ QK + VITQN+DGLH AG+ + ELHG L + C C E
Sbjct: 88 HQWIAQLENQ---QKSLGVITQNIDGLHEDAGSHNIDELHGTLNRFYCINCYEE------ 138
Query: 205 PICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMS 384
Y + L +C+K CG ++RP IV +GE L + A +
Sbjct: 139 -------------YSKSYVMTHHLKYCEK--CGNVIRPDIVLYGEMLNQKTVFKALDKIQ 183
Query: 385 TCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
D +V+G+S VV PAA F + ++ N + TP
Sbjct: 184 HADTLIVLGSSLVVQPAAGFVSEFKGDNLVI--INRDATP 221
>UniRef50_A5UYK2 Cluster: Silent information regulator protein Sir2;
n=2; Roseiflexus|Rep: Silent information regulator
protein Sir2 - Roseiflexus sp. RS-1
Length = 261
Score = 68.1 bits (159), Expect = 2e-10
Identities = 52/161 (32%), Positives = 71/161 (44%)
Frame = +1
Query: 19 AGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNN 198
A H+A+A E + + +ITQN DGLH RAG++ + ELHG+L C +C+ +
Sbjct: 87 AAHYALAALEQHRTLR---AIITQNFDGLHQRAGSREVYELHGHLRTATCLECERQIPTQ 143
Query: 199 DSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHA 378
PR G P P C CG L+P +V F E L + A A
Sbjct: 144 A--------LLPRIRRGE---P----PRCS---CGHPLKPDVVLFDEMLPRGLYWLARRA 185
Query: 379 MSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
+ DV +V GTS V+P GA + N PT
Sbjct: 186 VEHADVIIVAGTSLEVFPVNDLPALGLRHGAKLIIINNGPT 226
>UniRef50_A0PU12 Cluster: Sir2-like regulatory protein; n=1;
Mycobacterium ulcerans Agy99|Rep: Sir2-like regulatory
protein - Mycobacterium ulcerans (strain Agy99)
Length = 283
Score = 68.1 bits (159), Expect = 2e-10
Identities = 55/189 (29%), Positives = 85/189 (44%), Gaps = 14/189 (7%)
Frame = +1
Query: 19 AGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNN 198
AGH A+A E + VITQNVD LH +AG+K ++ LHG + C C ++
Sbjct: 76 AGHRALAALER---AGVVTGVITQNVDLLHTKAGSKNVVNLHGTYAQVTCLGCGHT-ISR 131
Query: 199 DSPICTCK*RSPRF*-----YGGFDIP---------VKLLPHCKKAHCGALLRPHIVWFG 336
+ + +P F GG + + + CG +L+P IV+FG
Sbjct: 132 STLAAELESLNPGFIERAEAVGGLAVAPDADAVIADTESFRYIDCRCCGGMLKPDIVYFG 191
Query: 337 ESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLI 516
ES+ + ++ A + D LV G+S V+ F AA+RG VA N T + +
Sbjct: 192 ESVPKEPVDQAFSLVDQSDALLVAGSSLTVFSGYRFLRHAAARGIPVAIINRGHTRGDDL 251
Query: 517 SIFYFEGPC 543
+ +G C
Sbjct: 252 ADVKVDGGC 260
>UniRef50_Q8R216 Cluster: NAD-dependent deacetylase sirtuin-4; n=7;
cellular organisms|Rep: NAD-dependent deacetylase
sirtuin-4 - Mus musculus (Mouse)
Length = 333
Score = 68.1 bits (159), Expect = 2e-10
Identities = 48/167 (28%), Positives = 80/167 (47%), Gaps = 12/167 (7%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVN----------NDSPICTCK*R 228
++TQNVD LH++AG++RL ELHG +++ C C E N S +
Sbjct: 137 LVTQNVDALHSKAGSQRLTELHGCMHRVLCLNCGEQTARRVLQERFQALNPSWSAEAQGV 196
Query: 229 SPRF*YGGFDIPVK--LLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCL 402
+P + V+ +P C + CG L+P +V+FG+++ D ++ + D L
Sbjct: 197 APDGDVFLTEEQVRSFQVPCCDR--CGGPLKPDVVFFGDTVNPDKVDFVHRRVKEADSLL 254
Query: 403 VVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEGPC 543
VVG+S VY F A + +A NI PT ++ ++ + C
Sbjct: 255 VVGSSLQVYSGYRFILTAREQKLPIAILNIGPTRSDDLACLKLDSRC 301
>UniRef50_Q8IRR5 Cluster: CG3187-PC, isoform C; n=4; Diptera|Rep:
CG3187-PC, isoform C - Drosophila melanogaster (Fruit
fly)
Length = 312
Score = 67.7 bits (158), Expect = 2e-10
Identities = 52/188 (27%), Positives = 86/188 (45%), Gaps = 13/188 (6%)
Frame = +1
Query: 19 AGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNN 198
A H A+A+FE Q V+TQNVD LH +AG++ ++E+HG+ Y +C C+ + +
Sbjct: 114 ATHHALARFEREERVQ---AVVTQNVDRLHTKAGSRNVVEVHGSGYVVKCLSCEYRIDRH 170
Query: 199 DSPICTCK*RSPRF--------*YGGFDIPVKL-----LPHCKKAHCGALLRPHIVWFGE 339
+ +P F G +IP++ +P C CG L+P IV+FG+
Sbjct: 171 EFQSILAS-LNPAFKDAPDMIRPDGDVEIPLEYIENFRIPEC--TQCGGDLKPEIVFFGD 227
Query: 340 SLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLIS 519
S+ ++ + D LV+G+S +V+ Q V NI T A+ ++
Sbjct: 228 SVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQTKDLKLPVGIVNIGETRADHLA 287
Query: 520 IFYFEGPC 543
C
Sbjct: 288 DIKISAKC 295
>UniRef50_Q7JMD3 Cluster: Putative uncharacterized protein sir-2.2;
n=4; Caenorhabditis|Rep: Putative uncharacterized
protein sir-2.2 - Caenorhabditis elegans
Length = 289
Score = 67.3 bits (157), Expect = 3e-10
Identities = 52/177 (29%), Positives = 85/177 (48%), Gaps = 15/177 (8%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEV------ 186
H+A++K+E S + +ITQNVDGLH +AG+K + ELHG+ + +CT C +
Sbjct: 100 HYALSKWE---ASDRFQWLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYIESRQTY 156
Query: 187 --LVNNDSPICTCK*RSPRF*YGGFDIPVKL-------LPHCKKAHCGALLRPHIVWFGE 339
++ +P + +P DI + L +P C CG L++ + +FGE
Sbjct: 157 QDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPS--CGGLMKTDVTFFGE 214
Query: 340 SLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPAN 510
++ D + ++ CD L +GTS V F A + + NI PT A+
Sbjct: 215 NVNMDKVNFCYEKVNECDGILSLGTSLAVLSGFRFIHHANMKKKPIFIVNIGPTRAD 271
>UniRef50_A4A8B4 Cluster: Silent information regulator protein Sir2;
n=1; Congregibacter litoralis KT71|Rep: Silent
information regulator protein Sir2 - Congregibacter
litoralis KT71
Length = 297
Score = 66.9 bits (156), Expect = 4e-10
Identities = 57/176 (32%), Positives = 81/176 (46%), Gaps = 13/176 (7%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND 201
GH +A+ E +HG I +TQNVD LH RAG+ R+ +LHG L + RC C E L + D
Sbjct: 87 GHRLLAQLE-HHGLVSHI--VTQNVDRLHQRAGSIRVTDLHGRLDRVRCLGC-ETLSSRD 142
Query: 202 SPICTCK*RSPRF*Y--------GGFDIPVKL-----LPHCKKAHCGALLRPHIVWFGES 342
+ +P + G D+P + +P C C L P +V+FG S
Sbjct: 143 VLQKALERLNPHINHTTIEARPDGDADMPDAMVEGITVPSCDL--CDGTLMPDVVFFGGS 200
Query: 343 LEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPAN 510
+ +E + + + LVVG+S VY F AA G V N T A+
Sbjct: 201 IPGSRVEQCKQVLEHSNSVLVVGSSLQVYSGYRFCKWAAKAGKPVFLMNPGQTRAD 256
>UniRef50_Q5BVX8 Cluster: SJCHGC08739 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC08739 protein - Schistosoma
japonicum (Blood fluke)
Length = 179
Score = 66.9 bits (156), Expect = 4e-10
Identities = 29/57 (50%), Positives = 42/57 (73%), Gaps = 1/57 (1%)
Frame = +1
Query: 19 AGHFAIAKFEDNH-GSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEV 186
+GH A+A+ E + S + VITQNVD LHA+AG+ ++ELHGN+YKTRC +C ++
Sbjct: 118 SGHLALAQAEKLYVDSGRSFFVITQNVDDLHAKAGSGNILELHGNVYKTRCLECNDI 174
>UniRef50_A1CTI6 Cluster: SIR2 family histone deacetylase, putative;
n=8; Eurotiomycetidae|Rep: SIR2 family histone
deacetylase, putative - Aspergillus clavatus
Length = 320
Score = 66.1 bits (154), Expect = 6e-10
Identities = 37/77 (48%), Positives = 47/77 (61%), Gaps = 3/77 (3%)
Frame = +1
Query: 274 LPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMST---CDVCLVVGTSSVVYPAAMF 444
LPHC + G LLRP +VWFGESL L A + M + D+ LV+GTSS VYPAA +
Sbjct: 210 LPHCPECKEG-LLRPGVVWFGESLPSQTLRAVDKWMDSGPKVDLILVIGTSSRVYPAAGY 268
Query: 445 APQAASRGAIVAEFNIE 495
+A GA VA N++
Sbjct: 269 VDRARQLGAKVAVINMD 285
Score = 35.1 bits (77), Expect = 1.4
Identities = 20/58 (34%), Positives = 32/58 (55%), Gaps = 2/58 (3%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAG--TKRLIELHGNLYKTRCT 171
KA H+A+A+ + + +TQNVD L RA +++L LHG+L+ +CT
Sbjct: 82 KAKPNRAHYALAELARRN---RDFITLTQNVDDLSQRANHPSEQLHLLHGSLFTVKCT 136
>UniRef50_Q6MJJ2 Cluster: NAD-dependent deacetylase; n=5;
Proteobacteria|Rep: NAD-dependent deacetylase -
Bdellovibrio bacteriovorus
Length = 235
Score = 66.1 bits (154), Expect = 6e-10
Identities = 54/155 (34%), Positives = 73/155 (47%), Gaps = 1/155 (0%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
++TQNVD LH RAG+K L+ +HG L + C C E F + D
Sbjct: 92 LVTQNVDNLHRRAGSKNLLHMHGRLDRVFCLHCDE-----------------HFEWL-LD 133
Query: 259 IPV-KLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPA 435
+ V + PHC + G + RP IVWFGE H +E A+ D + +GTS VYPA
Sbjct: 134 LAVDQPCPHCGRK--GGV-RPDIVWFGEMPHH--MEEIYEALDKADYFISIGTSGNVYPA 188
Query: 436 AMFAPQAASRGAIVAEFNIEPTPANLISIFYFEGP 540
A F A I E N++ T + +F GP
Sbjct: 189 AGFVRLAWKAKKI--EINLKDTEISPAFDEHFVGP 221
>UniRef50_Q6AF12 Cluster: Regulatory protein, Sir2 family; n=2;
Actinobacteria (class)|Rep: Regulatory protein, Sir2
family - Leifsonia xyli subsp. xyli
Length = 283
Score = 65.7 bits (153), Expect = 9e-10
Identities = 46/160 (28%), Positives = 78/160 (48%), Gaps = 12/160 (7%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVL---- 189
GH A+A ED + V+TQNVDGLH +AG++R+++LHG++ + C C ++
Sbjct: 92 GHRALAALEDAGAAAG---VVTQNVDGLHKKAGSRRVVDLHGSVDRVLCLVCGQLFAREA 148
Query: 190 ----VNNDSPICTCK*RSPRF*YGG----FDIPVKLLPHCKKAHCGALLRPHIVWFGESL 345
++ +P + + F G DI ++P C CG L+P +V+FGE +
Sbjct: 149 ITAGIDAANPWLDAE-GAVEFAPDGDAIVTDIDAFVIPDC--TVCGERLKPDVVFFGEFI 205
Query: 346 EHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASR 465
+ A + + D ++ G+S VV +A R
Sbjct: 206 PAETYREASALVRSADALVIAGSSLVVNSGVRLLEEARRR 245
>UniRef50_Q1QTH0 Cluster: Silent information regulator protein Sir2;
n=2; Oceanospirillales|Rep: Silent information regulator
protein Sir2 - Chromohalobacter salexigens (strain DSM
3043 / ATCC BAA-138 / NCIMB13768)
Length = 242
Score = 65.7 bits (153), Expect = 9e-10
Identities = 55/151 (36%), Positives = 77/151 (50%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE 183
+A A H A+A+ E G Q ++VITQN+D LH RAG++ ++ LHG E
Sbjct: 67 QATPNAAHRALAELEQA-GFQ--VSVITQNIDDLHERAGSRDVLHLHG-----------E 112
Query: 184 VLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILE 363
+L++ S P Y ++L C K G+ LRP +VWFGE + +
Sbjct: 113 ILMSRSSA-------DPNLRYPVGRKGIRLGDLCDK---GSQLRPDVVWFGEPVPR-YAQ 161
Query: 364 AAEHAMSTCDVCLVVGTSSVVYPAAMFAPQA 456
A E ++ D+ LVVGTS V PAAM QA
Sbjct: 162 ACE-IVAEADLVLVVGTSLAVMPAAMLLDQA 191
>UniRef50_A3LRA1 Cluster: Transcriptional regulatory protein; n=2;
Saccharomycetales|Rep: Transcriptional regulatory
protein - Pichia stipitis (Yeast)
Length = 311
Score = 65.7 bits (153), Expect = 9e-10
Identities = 32/83 (38%), Positives = 50/83 (60%), Gaps = 3/83 (3%)
Frame = +1
Query: 256 DIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEH---AMSTCDVCLVVGTSSVV 426
+IP LP C G+LLRP +VWFGESL +++ + ++ + ++ D+ LV+GTS V
Sbjct: 194 NIPESELPQCPVCKDGSLLRPGVVWFGESLPLNVMNSVDNFIESNNSVDLILVIGTSGTV 253
Query: 427 YPAAMFAPQAASRGAIVAEFNIE 495
YPA + + +G VA FN +
Sbjct: 254 YPANSYVDRVKVKGGKVAIFNTD 276
Score = 41.5 bits (93), Expect = 0.016
Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 7/72 (9%)
Frame = +1
Query: 4 KANYTAGHFAIAKFED---NHGSQKKITVITQNVDGLHARAG--TKRLIELHGNLYKTRC 168
+A GH A++ + S + ITQNVDGL +R+G + L E+HG+L+ C
Sbjct: 76 QAKPNKGHLALSALSNLATRKDSNLEYITITQNVDGLSSRSGHAKENLYEIHGSLFNLNC 135
Query: 169 TK--CKEVLVNN 198
T C V NN
Sbjct: 136 TSFMCNYVDRNN 147
>UniRef50_Q1RPU9 Cluster: Zinc finger protein; n=1; Ciona
intestinalis|Rep: Zinc finger protein - Ciona
intestinalis (Transparent sea squirt)
Length = 320
Score = 65.3 bits (152), Expect = 1e-09
Identities = 48/165 (29%), Positives = 75/165 (45%), Gaps = 12/165 (7%)
Frame = +1
Query: 85 TQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNN----DSPICTCK*RSPRF*YGG 252
TQNVDGL +AG ++L ELHG + + C +C +L N D + YG
Sbjct: 150 TQNVDGLMVKAGAEQLTELHGQMRRVVCMRCNGLLDRNVMQKDMDELNKHWSAEVLGYGP 209
Query: 253 F--------DIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVV 408
D+ +P C+K CG L+P++ +FG+++ + + CD LVV
Sbjct: 210 DADVFICEEDVIDFNVPACRK--CGGDLKPNVTFFGDNVPGSKVTFVRSIVDKCDGVLVV 267
Query: 409 GTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEGPC 543
G+S V+ F QA G +A N+ T A+ + + C
Sbjct: 268 GSSLHVWSGYRFITQAHELGVPIAIVNVGETRADKFAAVKIDALC 312
>UniRef50_Q7S223 Cluster: Putative uncharacterized protein
NCU05973.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU05973.1 - Neurospora crassa
Length = 334
Score = 65.3 bits (152), Expect = 1e-09
Identities = 38/83 (45%), Positives = 50/83 (60%), Gaps = 4/83 (4%)
Frame = +1
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMST---CDVCLVVGTSSVVY 429
IP LPHC + C LLRP +VWFGESL +L + + D+ LV+GTSSVVY
Sbjct: 196 IPKSHLPHCPQ--CKNLLRPGVVWFGESLNPGMLAEIDAWIDQGGPIDIVLVIGTSSVVY 253
Query: 430 PAAMFAPQAASRG-AIVAEFNIE 495
PAA +A +A ++G V N+E
Sbjct: 254 PAAGYAEKARTKGKTSVVTVNME 276
Score = 37.1 bits (82), Expect = 0.34
Identities = 25/72 (34%), Positives = 39/72 (54%), Gaps = 7/72 (9%)
Frame = +1
Query: 19 AGHFAIAKFEDNHGSQKKITVITQNVDGLHARAG--TKRLIELHGNLYKTRC----TKCK 180
AGH A+A + + +TQNVD L +RAG ++L LHG+L+ +C ++C
Sbjct: 84 AGHHALAALAKKNPN---FLCLTQNVDNLSSRAGHQQQQLHTLHGSLFTLQCSSYPSQCT 140
Query: 181 EVLVNND-SPIC 213
+ NN P+C
Sbjct: 141 YIDKNNTLDPLC 152
>UniRef50_A4RCT8 Cluster: Putative uncharacterized protein; n=3;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 1040
Score = 65.3 bits (152), Expect = 1e-09
Identities = 36/79 (45%), Positives = 47/79 (59%), Gaps = 4/79 (5%)
Frame = +1
Query: 268 KLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMST----CDVCLVVGTSSVVYPA 435
K LP C K LLRP IVWFGESL D ++ A+ D+CLV+GTS+ V+PA
Sbjct: 244 KDLPQCPKCK-SELLRPGIVWFGESLPEDTVDKADALFQDEADPIDLCLVIGTSAKVWPA 302
Query: 436 AMFAPQAASRGAIVAEFNI 492
A + +A +GA VA N+
Sbjct: 303 AGYVDEARDKGARVAVVNL 321
Score = 39.9 bits (89), Expect = 0.049
Identities = 18/33 (54%), Positives = 24/33 (72%), Gaps = 2/33 (6%)
Frame = +1
Query: 76 TVITQNVDGLHARAG--TKRLIELHGNLYKTRC 168
T++TQNVD L RAG +L+ELHGNL+ +C
Sbjct: 115 TMLTQNVDNLSPRAGHPADQLLELHGNLFDLKC 147
>UniRef50_A3ZMQ7 Cluster: Sir2 family, possible ADP
ribosyltransferase; n=1; Blastopirellula marina DSM
3645|Rep: Sir2 family, possible ADP ribosyltransferase -
Blastopirellula marina DSM 3645
Length = 252
Score = 64.9 bits (151), Expect = 1e-09
Identities = 54/167 (32%), Positives = 80/167 (47%)
Frame = +1
Query: 19 AGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNN 198
AGH +A +E HG + + ITQN+DGLH AG+++++ELHG + C C
Sbjct: 83 AGHQILAAWEA-HGVARGL--ITQNIDGLHQIAGSRQVLELHGTAREATCLDCAARF--E 137
Query: 199 DSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHA 378
P+ +F G ++P P+C+ L+ V FG+ L D+LE A
Sbjct: 138 IDPLVV------QFRETG-EVPP--CPNCETGR----LKHATVSFGQMLPTDVLETAYDW 184
Query: 379 MSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLIS 519
S D+ L +G+S VV PAA RG V N + T + I+
Sbjct: 185 CSDADLILAIGSSLVVTPAADLPVAVRRRGGRVVILNRDETGLDQIA 231
>UniRef50_A3WK56 Cluster: SIR2-like regulatory protein,
NAD-dependent protein deacetylase; n=1; Idiomarina
baltica OS145|Rep: SIR2-like regulatory protein,
NAD-dependent protein deacetylase - Idiomarina baltica
OS145
Length = 279
Score = 64.9 bits (151), Expect = 1e-09
Identities = 54/156 (34%), Positives = 74/156 (47%), Gaps = 12/156 (7%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H IA+F+ HG TVITQNVDGLH +AG+ +I LHG C C + D
Sbjct: 86 HQVIAQFQQ-HGFID--TVITQNVDGLHQKAGSSTVINLHGYANDIVCMTCGDRSPRFDL 142
Query: 205 PICTCK*RSPRF*YGGF----DIPVKL--------LPHCKKAHCGALLRPHIVWFGESLE 348
+ +PRF D KL L HC HCG +L+P +V+FG+++
Sbjct: 143 HQRYAE-LNPRFNQSVSVIKPDGDAKLSAPTDEFKLIHCD--HCGGILKPDVVYFGDNVP 199
Query: 349 HDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQA 456
+EA A+ L+VG+S V+ FA A
Sbjct: 200 KKRVEACYQAIDDSQGLLIVGSSLKVFSGFRFARYA 235
>UniRef50_O07595 Cluster: NAD-dependent deacetylase; n=3;
Bacillus|Rep: NAD-dependent deacetylase - Bacillus
subtilis
Length = 247
Score = 64.5 bits (150), Expect = 2e-09
Identities = 48/162 (29%), Positives = 75/162 (46%), Gaps = 2/162 (1%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND 201
GH +A+ E K++ + TQN+DGLH +AG++ + ELHG++ C C D
Sbjct: 81 GHLLLAELEKQG---KQVDIFTQNIDGLHKKAGSRHVYELHGSIQTAACPACG---ARYD 134
Query: 202 SPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAM 381
P + ++P CG +L+ +V FG+++ H + +
Sbjct: 135 LPHLLER-----------EVPECTAAGNNGDICGTVLKTDVVLFGDAVMH--FDTLYEKL 181
Query: 382 STCDVCLVVGTSSVVYPAAMFAPQAAS--RGAIVAEFNIEPT 501
D+ LV+GTS V P A F P+ AS G N+EPT
Sbjct: 182 DQADLLLVIGTSLEVAP-ARFVPEDASLIPGMKKVIINLEPT 222
>UniRef50_Q1D9X2 Cluster: Sir2 family protein; n=1; Myxococcus
xanthus DK 1622|Rep: Sir2 family protein - Myxococcus
xanthus (strain DK 1622)
Length = 287
Score = 64.1 bits (149), Expect = 3e-09
Identities = 56/177 (31%), Positives = 88/177 (49%), Gaps = 13/177 (7%)
Frame = +1
Query: 1 AKANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKC- 177
+ A A H A+A+ E G + + ITQNVDGLH AG+ R+IELHG L + RC C
Sbjct: 86 SSARPNAAHAALAELEQA-GHVRGL--ITQNVDGLHHAAGSSRVIELHGALAQVRCLACG 142
Query: 178 ----KEVL---VNNDSPICTCK*RSPRF*YGGFDIPVKLL-----PHCKKAHCGALLRPH 321
+E L + + +P + + R G D+ + L P C CG L+P
Sbjct: 143 AQEAREALQARLLSLNPGFSLEVLELR-PDGDADLTSEQLSSFQVPAC--LVCGGTLKPD 199
Query: 322 IVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNI 492
+V+FG+++ + +A + D LVVG+S ++ F +A+ R +A N+
Sbjct: 200 VVFFGDNVPVPTVASAFALLEEGDALLVVGSSLAIFSGYRFLVRASERRMPIAILNL 256
>UniRef50_A6SP88 Cluster: Putative uncharacterized protein; n=2;
Sclerotiniaceae|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 332
Score = 64.1 bits (149), Expect = 3e-09
Identities = 35/76 (46%), Positives = 47/76 (61%), Gaps = 2/76 (2%)
Frame = +1
Query: 274 LPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAM--STCDVCLVVGTSSVVYPAAMFA 447
LPHC + ALLRP IVWFGE+L D L+ + + + D+ LVVGT++ VYPAA +
Sbjct: 213 LPHCPQCTT-ALLRPDIVWFGEALPEDTLDEVDRWIDKAPVDLILVVGTTAKVYPAAGYV 271
Query: 448 PQAASRGAIVAEFNIE 495
A GA VA N++
Sbjct: 272 DVARGAGARVAVINMD 287
Score = 32.7 bits (71), Expect = 7.4
Identities = 20/53 (37%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Frame = +1
Query: 22 GHFAIAKFEDN--HGSQKKITVITQNVDGLHARAGTKR--LIELHGNLYKTRC 168
GHFA+ + ++ +TQNVDGL RAG L LHG+L +C
Sbjct: 102 GHFALGELAKRMKKDGEEGFMCLTQNVDGLAQRAGHPEGSLKLLHGSLCDIKC 154
>UniRef50_Q9Y6E7 Cluster: NAD-dependent deacetylase sirtuin-4; n=23;
Deuterostomia|Rep: NAD-dependent deacetylase sirtuin-4 -
Homo sapiens (Human)
Length = 314
Score = 64.1 bits (149), Expect = 3e-09
Identities = 52/183 (28%), Positives = 83/183 (45%), Gaps = 10/183 (5%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE-----VL 189
H+A++ +E K ++TQNVD LH +AG++RL ELHG + + C C E VL
Sbjct: 125 HWALSTWEK---LGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVL 181
Query: 190 -----VNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHD 354
V N + +P + V+ CG L+P +V+FG+++ D
Sbjct: 182 QERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPD 241
Query: 355 ILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFE 534
++ + D LVVG+S VY F A + +A NI PT ++ ++
Sbjct: 242 KVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLN 301
Query: 535 GPC 543
C
Sbjct: 302 SRC 304
>UniRef50_Q882K4 Cluster: NAD-dependent deacetylase 3; n=5;
Pseudomonas|Rep: NAD-dependent deacetylase 3 -
Pseudomonas syringae pv. tomato
Length = 281
Score = 63.7 bits (148), Expect = 3e-09
Identities = 51/172 (29%), Positives = 80/172 (46%), Gaps = 17/172 (9%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKC----------KEVLVNNDSPICTCK*R 228
+ITQNVD LH +AG++ +IELHG+L++ C C +++L +N +
Sbjct: 102 LITQNVDALHTQAGSQDVIELHGSLHRVLCLDCQQRSDRTAIQEQMLAHNLYLADVHATQ 161
Query: 229 SP-------RF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMST 387
+P GF +P PHC+ G L+P +V+FGE++ A ++
Sbjct: 162 APDGDTLLDPAYEAGFKVPE--CPHCQ----GKRLKPDVVFFGENVASHTAARATLSVEQ 215
Query: 388 CDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYFEGPC 543
+ LVVGTS + + A A +G V N T A+ + E PC
Sbjct: 216 AEGLLVVGTSLMAWSAFRLCKAMAEQGKPVIAINHGKTRADELLRMKIEAPC 267
>UniRef50_Q9USN7 Cluster: Sir2 family histone deacetylase Hst2; n=1;
Schizosaccharomyces pombe|Rep: Sir2 family histone
deacetylase Hst2 - Schizosaccharomyces pombe (Fission
yeast)
Length = 332
Score = 63.3 bits (147), Expect = 5e-09
Identities = 48/143 (33%), Positives = 63/143 (44%), Gaps = 2/143 (1%)
Frame = +1
Query: 16 TAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVL 189
T H+ I D QK TQN+D L AG K LIE HG+ +RC +C E+
Sbjct: 97 TYTHYFIRLLHDKRLLQK---CYTQNIDTLERLAGVPDKALIEAHGSFQYSRCIECYEMA 153
Query: 190 VNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAA 369
C I K +P C C L++P IV++GE L E
Sbjct: 154 ETEYVRAC---------------IMQKQVPKCNS--CKGLIKPMIVFYGEGLPMRFFEHM 196
Query: 370 EHAMSTCDVCLVVGTSSVVYPAA 438
E CD+ LV+GTS +V+P A
Sbjct: 197 EKDTKVCDMALVIGTSLLVHPFA 219
>UniRef50_A4QUX8 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 460
Score = 62.9 bits (146), Expect = 6e-09
Identities = 40/131 (30%), Positives = 68/131 (51%), Gaps = 2/131 (1%)
Frame = +1
Query: 85 TQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
TQN+D L +AG +++IE HG+ C +CKE+ +++ +
Sbjct: 129 TQNIDCLERQAGVPGEKVIEAHGSFATQSCIECKELFPDDEMLL---------------H 173
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
+ +++P C A C L++P+IV+FGE L E H ++ D+ +++GTS VYP A
Sbjct: 174 VEKEIVPRC--ASCNGLVKPNIVFFGEPLPRTFSEKC-HLVAESDLAIIIGTSLTVYPFA 230
Query: 439 MFAPQAASRGA 471
P+ RG+
Sbjct: 231 GL-PELVPRGS 240
>UniRef50_Q54LF0 Cluster: Ankyrin repeat-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: Ankyrin
repeat-containing protein - Dictyostelium discoideum AX4
Length = 778
Score = 62.5 bits (145), Expect = 8e-09
Identities = 49/164 (29%), Positives = 71/164 (43%), Gaps = 2/164 (1%)
Frame = +1
Query: 16 TAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTK--RLIELHGNLYKTRCTKCKEVL 189
T H+ I + +G + TQNVD L R GT ++I HG+ + CT C++
Sbjct: 566 TKSHYFINDLNEKYGCL--LRNYTQNVDPLQERTGTPTDKIIHAHGSFDQWYCTVCQKQY 623
Query: 190 VNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAA 369
+ I GG LP C + C ++RP++V+FGE L D
Sbjct: 624 TDKSDRIWR------EIGRGG-------LPFCTEPECRHVIRPNVVFFGEPLSQDFRVNT 670
Query: 370 EHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
D+ +V+GTS +VYP A AS + FN E T
Sbjct: 671 ITDFRKADLLIVMGTSLIVYPFASLVNDVASDVPRLL-FNFEST 713
>UniRef50_Q3S8X8 Cluster: IS-Sir2; n=3; Pseudomonas syringae
group|Rep: IS-Sir2 - Pseudomonas syringae pv.
phaseolicola
Length = 182
Score = 62.1 bits (144), Expect = 1e-08
Identities = 33/76 (43%), Positives = 39/76 (51%)
Frame = +1
Query: 277 PHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQA 456
P C + C LRP +VWFGE L + + A A CDV L +GTS VV+PAA A
Sbjct: 78 PRCPR--CNGKLRPGVVWFGEDLPIAVWKRAVGAAQGCDVLLSIGTSGVVFPAAEIPRIA 135
Query: 457 ASRGAIVAEFNIEPTP 504
GA V N TP
Sbjct: 136 LKSGARVVHINTTETP 151
>UniRef50_Q8R984 Cluster: NAD-dependent deacetylase 2; n=1;
Thermoanaerobacter tengcongensis|Rep: NAD-dependent
deacetylase 2 - Thermoanaerobacter tengcongensis
Length = 250
Score = 62.1 bits (144), Expect = 1e-08
Identities = 39/118 (33%), Positives = 59/118 (50%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
VITQN+D LH +AG+K++ E+HGN + C +C E + K P
Sbjct: 104 VITQNIDNLHQKAGSKKVYEVHGNTREGSCLRCGEKVSFELLEEKVAKEEIP-------- 155
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYP 432
P C + CG +LRP +V FG+ + H + A + D+ +V+G+S VV P
Sbjct: 156 ------PRCDR--CGGMLRPDVVLFGDPMPH-AFDLALKEVQESDLLIVIGSSLVVAP 204
>UniRef50_A6TNA0 Cluster: Silent information regulator protein Sir2;
n=1; Alkaliphilus metalliredigens QYMF|Rep: Silent
information regulator protein Sir2 - Alkaliphilus
metalliredigens QYMF
Length = 249
Score = 61.7 bits (143), Expect = 1e-08
Identities = 45/137 (32%), Positives = 68/137 (49%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND 201
GH+ ++ E G + I TQNV GLH AG++ + ELHGN+ K RC C N++
Sbjct: 91 GHYILSDLEKK-GMIRSIA--TQNVAGLHVMAGSQNVYELHGNIRKIRCNNC-----NHE 142
Query: 202 SPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAM 381
+ + RF + V+ C LRP ++ FGE+L ++A +
Sbjct: 143 ASL-------ERF------LAVETCGSCGDKG----LRPSVILFGETLPPKAWDSALRDI 185
Query: 382 STCDVCLVVGTSSVVYP 432
CD+ +V+GTS VYP
Sbjct: 186 QKCDLLIVIGTSLEVYP 202
>UniRef50_A2F8E1 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 331
Score = 61.7 bits (143), Expect = 1e-08
Identities = 37/123 (30%), Positives = 58/123 (47%), Gaps = 3/123 (2%)
Frame = +1
Query: 79 VITQNVDGLHARAGTK--RLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*R-SPRF*YG 249
V TQNVDGL G +L++ HG L C C + P+ C + P F
Sbjct: 112 VYTQNVDGLEIPGGLPEDKLVQCHGALPTCHCCDCHAAV-----PLAECLRQIQPNFENR 166
Query: 250 GFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVY 429
++ ++PHC G ++P + +FGE++ + +CD+C++ GTS VY
Sbjct: 167 RLNMTNAVVPHCPSCD-GEHVKPDVTFFGEAMPDRFEQTLYEDFHSCDLCIITGTSLGVY 225
Query: 430 PAA 438
P A
Sbjct: 226 PFA 228
>UniRef50_Q9RL35 Cluster: NAD-dependent deacetylase 1; n=8;
Actinomycetales|Rep: NAD-dependent deacetylase 1 -
Streptomyces coelicolor
Length = 299
Score = 61.7 bits (143), Expect = 1e-08
Identities = 54/184 (29%), Positives = 84/184 (45%), Gaps = 11/184 (5%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE 183
+A AGH ++A F HG VITQNVDGLH AG++ ++ELHG+L + C C
Sbjct: 92 RARPNAGHRSVAAF-GRHGLLTG--VITQNVDGLHQAAGSEGVVELHGSLDRVVCLSC-G 147
Query: 184 VLVNNDSPICTCK*RSPRF--------*YGGFDIPVKLLPHCKKAHC---GALLRPHIVW 330
VL + + F G D+ + + + C G +L+P +V+
Sbjct: 148 VLSPRRELARRLEEANAGFSPVAAGINPDGDADLTDEQVGDFRVVPCAVCGGVLKPDVVF 207
Query: 331 FGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPAN 510
FGE++ +E + LV+G+S V F QAA G V N + T +
Sbjct: 208 FGENVPPRRVEHCRELVRGASSLLVLGSSLTVMSGLRFVRQAAEAGKPVLIVNRDATRGD 267
Query: 511 LISI 522
+++
Sbjct: 268 RLAV 271
>UniRef50_Q839C6 Cluster: NAD-dependent deacetylase; n=14;
Bacilli|Rep: NAD-dependent deacetylase - Enterococcus
faecalis (Streptococcus faecalis)
Length = 237
Score = 61.3 bits (142), Expect = 2e-08
Identities = 43/155 (27%), Positives = 70/155 (45%)
Frame = +1
Query: 67 KKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*Y 246
K+ +++QN+DGLH +AG++ +++ HGNLY+ C C + D
Sbjct: 93 KRGKIVSQNIDGLHRKAGSQEVVDFHGNLYECYCQTCGATVPWQD--------------- 137
Query: 247 GGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVV 426
L + A C +RP I + E L + +E A A+++ D+ ++VGTS V
Sbjct: 138 --------YLLSDRHADCHGQIRPAITLYEEGLSEEAIEKAIQAVASADLIVIVGTSFQV 189
Query: 427 YPAAMFAPQAASRGAIVAEFNIEPTPANLISIFYF 531
+P I+A I TP L +YF
Sbjct: 190 HPFCDLIHYKQPTATILA---INQTPLFLQQPYYF 221
>UniRef50_Q8REC3 Cluster: NAD-dependent deacetylase; n=3;
Fusobacterium nucleatum|Rep: NAD-dependent deacetylase -
Fusobacterium nucleatum subsp. nucleatum
Length = 252
Score = 60.5 bits (140), Expect = 3e-08
Identities = 46/152 (30%), Positives = 68/152 (44%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND 201
GH A+ + E G K VITQN+D LH +G K ++ELHG+L + C C + N
Sbjct: 90 GHMALVELE-KIGILK--AVITQNIDDLHQVSGNKNVLELHGSLKRWYCLSCGKTADRNF 146
Query: 202 SPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAM 381
S C C GG ++RP + +GE+L ++ A + +
Sbjct: 147 S--CEC---------GG------------------VVRPDVTLYGENLNQSVVNEAIYQL 177
Query: 382 STCDVCLVVGTSSVVYPAAMFAPQAASRGAIV 477
D +V GTS VYPAA + + I+
Sbjct: 178 EQADTLIVAGTSLTVYPAAYYLRYFRGKNLII 209
>UniRef50_A6G0H3 Cluster: Silent information regulator protein Sir2;
n=1; Plesiocystis pacifica SIR-1|Rep: Silent information
regulator protein Sir2 - Plesiocystis pacifica SIR-1
Length = 288
Score = 60.1 bits (139), Expect = 4e-08
Identities = 49/164 (29%), Positives = 74/164 (45%), Gaps = 4/164 (2%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVLVNN 198
H A+ + E G ++ ++TQNVDGLH RAG +R IE+HGN T + +
Sbjct: 100 HEALVRLEQALG--ERFCLVTQNVDGLHLRAGNSRERTIEVHGN------TDYMRPIEGD 151
Query: 199 DSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDIL--EAAE 372
+P+ + PR D + A G RPH++WF E E ++ ++A
Sbjct: 152 RTPVPIPE-AMPRVQKD--DPMTDAMWELLVADDGRRTRPHVLWFDEYYEEELFRSDSAL 208
Query: 373 HAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
A CD+ +VVGTS + A R A + + N P
Sbjct: 209 RAAGECDLIVVVGTSGAAAIPYHMSAAALERDAAIIDINPGQNP 252
>UniRef50_Q89LY4 Cluster: NAD-dependent deacetylase 1; n=12;
Proteobacteria|Rep: NAD-dependent deacetylase 1 -
Bradyrhizobium japonicum
Length = 254
Score = 60.1 bits (139), Expect = 4e-08
Identities = 52/169 (30%), Positives = 76/169 (44%), Gaps = 2/169 (1%)
Frame = +1
Query: 1 AKANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTK 174
A A GH A+A + + K VITQN+D LH +G + +IELHGN RC
Sbjct: 82 AAARPGRGHRALASL---YRAGKVPAVITQNIDNLHQASGFAHEHVIELHGNTTYARCVG 138
Query: 175 CKEVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHD 354
C + + K RF G P+C C ++ + FG+ + +
Sbjct: 139 CGQTY-----QLDWVK---RRFDQDG-------APNCTV--CDEPVKTATISFGQMMPEE 181
Query: 355 ILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
++ A CD+ + +G+S VV+PAA F A GA + N EPT
Sbjct: 182 EMQRATALSRACDLFIAIGSSLVVWPAAGFPMMAKRAGARLVIINREPT 230
>UniRef50_Q3A6W7 Cluster: NAD-dependent protein deacetylases, SIR2
family; n=2; Pelobacter|Rep: NAD-dependent protein
deacetylases, SIR2 family - Pelobacter carbinolicus
(strain DSM 2380 / Gra Bd 1)
Length = 278
Score = 59.7 bits (138), Expect = 6e-08
Identities = 44/143 (30%), Positives = 74/143 (51%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
+ITQN+D LH AG++++I+LHG+ +C C + + ++ T R+
Sbjct: 117 LITQNIDMLHQLAGSRKVIDLHGSYRSAQCLFCGK---SYEALSYTWWERA----MSTSS 169
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
P L +C C ++L+P IV+FGE + EAAE ++ CD+ LV+G+S V PA+
Sbjct: 170 KPP--LAYCSA--CNSVLKPDIVFFGEMVH--AFEAAEQLIAQCDLLLVLGSSLKVTPAS 223
Query: 439 MFAPQAASRGAIVAEFNIEPTPA 507
+ + +V + PA
Sbjct: 224 LLPYHTQATTVVVNRGAVMLPPA 246
>UniRef50_Q0AY57 Cluster: Regulatory protein, sir2 family; n=1;
Syntrophomonas wolfei subsp. wolfei str. Goettingen|Rep:
Regulatory protein, sir2 family - Syntrophomonas wolfei
subsp. wolfei (strain Goettingen)
Length = 253
Score = 59.3 bits (137), Expect = 7e-08
Identities = 39/142 (27%), Positives = 74/142 (52%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
++TQN+D LH +AG++++I +HGN + C + V++ + + T
Sbjct: 100 IVTQNIDNLHQKAGSQKVIPIHGNGARFLCQERNCRSVHDSNYVNTYP------------ 147
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
+++P C + CG +L+P +V FGE ++ + +A + + V +V+G+S VYP A
Sbjct: 148 ---EVIPRCSQ--CGGILKPDVVLFGEHIK-NYPDAMDRILG-ARVLVVIGSSLTVYPLA 200
Query: 439 MFAPQAASRGAIVAEFNIEPTP 504
F + ++ + N PTP
Sbjct: 201 GFVKEFSTFTQYLIIINKGPTP 222
>UniRef50_A0Z2E4 Cluster: NAD-dependent deacetylase; n=1; marine
gamma proteobacterium HTCC2080|Rep: NAD-dependent
deacetylase - marine gamma proteobacterium HTCC2080
Length = 288
Score = 59.3 bits (137), Expect = 7e-08
Identities = 46/163 (28%), Positives = 75/163 (46%), Gaps = 10/163 (6%)
Frame = +1
Query: 7 ANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKC--- 177
A A H A+ FE S + VITQNVD LH AG++ +I+LHG L + C C
Sbjct: 77 ARCNANHSALVDFEQ---SGRSTLVITQNVDRLHQAAGSQNVIDLHGRLDRVVCLDCGAG 133
Query: 178 -KEVLVNNDSPICTCK*R---SPRF*YGGFDIPVKLLPHCKKAHC---GALLRPHIVWFG 336
+ V + + R + G D+ + + C G +L+P +V+FG
Sbjct: 134 YERDRVQQELEELNPQHRGFEAMARPDGDADLSAEQVRDVNIWDCEVCGGMLKPDVVFFG 193
Query: 337 ESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASR 465
++ + + + A++ D LV+G+S V+ F QA +
Sbjct: 194 GTIPRERVTRCQEALTAADGLLVIGSSLQVFSGFRFCRQAVEQ 236
>UniRef50_A5DW75 Cluster: Putative uncharacterized protein; n=1;
Lodderomyces elongisporus NRRL YB-4239|Rep: Putative
uncharacterized protein - Lodderomyces elongisporus
(Yeast) (Saccharomyces elongisporus)
Length = 379
Score = 59.3 bits (137), Expect = 7e-08
Identities = 33/82 (40%), Positives = 45/82 (54%), Gaps = 3/82 (3%)
Frame = +1
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAM---STCDVCLVVGTSSVVY 429
I K LP C C LLRP +VWFGESL D++ ++ + D+ LV+GTS VY
Sbjct: 265 ISEKDLPRCPV--CSELLRPGVVWFGESLPLDVITKIDNFIEEDGPVDLILVIGTSGTVY 322
Query: 430 PAAMFAPQAASRGAIVAEFNIE 495
PA + + +G VA FN +
Sbjct: 323 PANSYVERVKYQGGKVAIFNTD 344
Score = 39.1 bits (87), Expect = 0.085
Identities = 21/47 (44%), Positives = 28/47 (59%), Gaps = 4/47 (8%)
Frame = +1
Query: 70 KITVITQNVDGLHARA--GTKRLIELHGNLYKTRCTK--CKEVLVNN 198
K ITQNVDGL +R+ + L E+HG+L+ +CT C V NN
Sbjct: 135 KFVTITQNVDGLSSRSEHDLQSLYEIHGSLFTLKCTSFMCNYVEKNN 181
>UniRef50_UPI0000499DEA Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 383
Score = 58.8 bits (136), Expect = 1e-07
Identities = 39/122 (31%), Positives = 59/122 (48%), Gaps = 2/122 (1%)
Frame = +1
Query: 79 VITQNVDGLHARAG--TKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGG 252
V TQN+DGL + AG ++I HG + C C + + I + K
Sbjct: 224 VYTQNIDGLESVAGIPNDKVICSHGTFRSSHCLSCHKKYPDTSVFIESIKKGE------- 276
Query: 253 FDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYP 432
+ HC +CG L++P IV+F ESL + E+ + CD+ L++GT+ VVYP
Sbjct: 277 -------IIHC---NCGGLIKPDIVFFNESLPDEFFESIKDKFDDCDMLLIIGTALVVYP 326
Query: 433 AA 438
A
Sbjct: 327 FA 328
>UniRef50_Q21921 Cluster: NAD-dependent deacetylase SIR2 homolog;
n=2; Caenorhabditis|Rep: NAD-dependent deacetylase SIR2
homolog - Caenorhabditis elegans
Length = 607
Score = 58.4 bits (135), Expect = 1e-07
Identities = 39/140 (27%), Positives = 64/140 (45%)
Frame = +1
Query: 85 TQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFDIP 264
TQN+D L + G KR++E HG+ K CT+C + N+ R ++
Sbjct: 236 TQNIDTLEHQTGIKRVVECHGSFSKCTCTRCGQKYDGNEI-------RE--------EVL 280
Query: 265 VKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMF 444
+ HCK+ C +++P+IV+FGE L + + D+ +V+G+S V P A+
Sbjct: 281 AMRVAHCKR--CEGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKVRPVALI 338
Query: 445 APQAASRGAIVAEFNIEPTP 504
P + N E P
Sbjct: 339 -PHCVDKNVPQILINRESLP 357
>UniRef50_Q8G465 Cluster: Sir2-type regulatory protein; n=2;
Bifidobacterium longum|Rep: Sir2-type regulatory protein
- Bifidobacterium longum
Length = 216
Score = 57.6 bits (133), Expect = 2e-07
Identities = 38/141 (26%), Positives = 61/141 (43%), Gaps = 2/141 (1%)
Frame = +1
Query: 85 TQNVDGLHARAGTKR--LIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
TQN D LH +AG ++ LHG + + C KC + D + P
Sbjct: 54 TQNFDALHEKAGNSDNVIVNLHGTIGTSHCMKCHQEYATADIMARLDEEPDPHC------ 107
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
+ L + C +++ +V+FGE+L +E + + D V+G++ VYPAA
Sbjct: 108 --HRKLKYRGDMPCNGIIKTDVVYFGEALPDGAMEKSYSLATKADELWVIGSTLEVYPAA 165
Query: 439 MFAPQAASRGAIVAEFNIEPT 501
P AA G + N+ T
Sbjct: 166 SIVPVAAQAGVPITIMNMGHT 186
>UniRef50_A6WG46 Cluster: Silent information regulator protein Sir2;
n=4; Actinomycetales|Rep: Silent information regulator
protein Sir2 - Kineococcus radiotolerans SRS30216
Length = 279
Score = 57.6 bits (133), Expect = 2e-07
Identities = 54/181 (29%), Positives = 77/181 (42%), Gaps = 15/181 (8%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE 183
+A H A+A E G+ VITQNVDGL AGT+ ++ELHGNL + C +C E
Sbjct: 74 RARPNDAHRAVAALE---GAGVVTGVITQNVDGLDLAAGTREVVELHGNLDRVVCLRCGE 130
Query: 184 VLVNNDSPICTCK*RSPRF*Y-----------GGFDIPVKLLPHCKKA---HCGA-LLRP 318
+ + +P F G D+ L + CG L+
Sbjct: 131 LTARAELAE-RLSAANPGFDARVEQLHALNPDGDADLTEAQLEGFRTVACRRCGEDALKA 189
Query: 319 HIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEP 498
+V+FGE++ D + + + V LV+G+S V F AA G VA P
Sbjct: 190 DVVFFGETVPKDRVARSFELLDAARVLLVLGSSLAVMSGYRFVLHAARNGQPVAIVTAGP 249
Query: 499 T 501
T
Sbjct: 250 T 250
>UniRef50_Q8N6T7 Cluster: Mono-ADP-ribosyltransferase sirtuin-6;
n=22; Euteleostomi|Rep: Mono-ADP-ribosyltransferase
sirtuin-6 - Homo sapiens (Human)
Length = 355
Score = 57.6 bits (133), Expect = 2e-07
Identities = 45/146 (30%), Positives = 66/146 (45%), Gaps = 5/146 (3%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKR--LIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGG 252
+++QNVDGLH R+G R L ELHGN++ C KCK V D+ + T G
Sbjct: 110 LVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYV-RDTVVGTM----------G 158
Query: 253 FDIPVKLLPHCKK---AHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSV 423
+L K C LR I+ + +SL L A+ A D+ + +GTS
Sbjct: 159 LKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQ 218
Query: 424 VYPAAMFAPQAASRGAIVAEFNIEPT 501
+ P+ RG + N++PT
Sbjct: 219 IRPSGNLPLATKRRGGRLVIVNLQPT 244
>UniRef50_A1A3R7 Cluster: Sir2-type regulatory protein; n=2;
Bifidobacterium adolescentis|Rep: Sir2-type regulatory
protein - Bifidobacterium adolescentis (strain ATCC
15703 / DSM 20083)
Length = 218
Score = 57.2 bits (132), Expect = 3e-07
Identities = 44/148 (29%), Positives = 68/148 (45%), Gaps = 9/148 (6%)
Frame = +1
Query: 85 TQNVDGLHARAGTKR--LIELHGNLYKTRCTKCK------EVLVNNDS-PICTCK*RSPR 237
TQN D LH +AG ++ LHG + + C KC E++ N D+ P C + P
Sbjct: 54 TQNFDALHEKAGNSSNVIVNLHGTIGTSHCMKCHAKYDTAEIMANLDNEPDPHCHRKLP- 112
Query: 238 F*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTS 417
Y G ++P C L++ +V+FGE+L +E + + D V+G++
Sbjct: 113 --YSG-NMP-----------CDGLIKTDVVYFGEALPDGAIEKSYRLAAQADELWVIGST 158
Query: 418 SVVYPAAMFAPQAASRGAIVAEFNIEPT 501
V PAA P AA G + N+ T
Sbjct: 159 LEVMPAASIVPVAAQAGVPITIMNMGRT 186
>UniRef50_Q22KA8 Cluster: Transcriptional regulator, Sir2 family
protein; n=3; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 386
Score = 57.2 bits (132), Expect = 3e-07
Identities = 54/171 (31%), Positives = 74/171 (43%), Gaps = 3/171 (1%)
Frame = +1
Query: 1 AKANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAG--TKRLIELHGNLYKTRCTK 174
++A T H A+ K + G K + I+QN+DGLH R+G L ELHGN +C K
Sbjct: 89 SRAVPTKSHMALVKL-NQEGILKYL--ISQNIDGLHRRSGFNPNSLSELHGNTNLEKCLK 145
Query: 175 CKEVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPH-CKKAHCGALLRPHIVWFGESLEH 351
C + + R R D+ L C CG L IV FGE+L
Sbjct: 146 CGKSYM-----------RDYRV-RKALDVHDHLTGRICDNQKCGGELVDTIVNFGENLPK 193
Query: 352 DILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
+E D+ LV+G+S V PAA A G + N++ TP
Sbjct: 194 KDMEQGFFNSKQADLHLVLGSSLRVTPAADMPLATAQNGNKLVVVNLQKTP 244
>UniRef50_A2DZ01 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 281
Score = 57.2 bits (132), Expect = 3e-07
Identities = 25/64 (39%), Positives = 39/64 (60%)
Frame = +1
Query: 298 CGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIV 477
CG++L+P + +F +++ I +AA +A+S+CD+ LVVGT V P F A G I+
Sbjct: 182 CGSVLKPQVAFFEDTIPRHIRDAAYNALSSCDLLLVVGTYCAVDPVLSFVRNAKRNGTIL 241
Query: 478 AEFN 489
E N
Sbjct: 242 VEIN 245
>UniRef50_Q3V7G9 Cluster: Putative cobalamin biosynthetic protein;
n=2; Acinetobacter|Rep: Putative cobalamin biosynthetic
protein - Acinetobacter sp. (strain ADP1)
Length = 233
Score = 56.8 bits (131), Expect = 4e-07
Identities = 38/123 (30%), Positives = 61/123 (49%)
Frame = +1
Query: 70 KITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YG 249
++ VITQN+D LH RAG+ ++ LHGN+ + + PI
Sbjct: 80 QVQVITQNIDDLHERAGSTHVLHLHGNIRLAKSSGPNAQFTQTFYPI------------D 127
Query: 250 GFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVY 429
G+ + + + K + G LRPH+VWFGE++ + A + DV +V+G++ VY
Sbjct: 128 GWQLDL----NQDKCNEGYPLRPHVVWFGEAV--PAYDDAIAMLKDADVFIVIGSTLSVY 181
Query: 430 PAA 438
P A
Sbjct: 182 PVA 184
>UniRef50_Q5KZE8 Cluster: NAD-dependent deacetylase 2; n=3;
Bacteria|Rep: NAD-dependent deacetylase 2 - Geobacillus
kaustophilus
Length = 247
Score = 56.8 bits (131), Expect = 4e-07
Identities = 45/153 (29%), Positives = 67/153 (43%)
Frame = +1
Query: 67 KKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*Y 246
K +T++TQN+DGLH +AG+ +IELHG L C P C K Y
Sbjct: 96 KTVTILTQNIDGLHTKAGSTNVIELHGTLQTATC------------PSCGNK-------Y 136
Query: 247 GGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVV 426
I +P C+K C +++P +V FG + +E A A + D+ L +GTS V
Sbjct: 137 DLSFINRHEVPRCEK--CQTIVKPDVVLFGGLVPR--MEEAFAAAAASDLLLAMGTSLEV 192
Query: 427 YPAAMFAPQAASRGAIVAEFNIEPTPANLISIF 525
P A+ + I T + +F
Sbjct: 193 APVNQIPFYVAAESPATRKVLINKTATRMDGMF 225
>UniRef50_Q54QE6 Cluster: Zn finger-containing protein; n=5;
Eukaryota|Rep: Zn finger-containing protein -
Dictyostelium discoideum AX4
Length = 512
Score = 56.4 bits (130), Expect = 5e-07
Identities = 47/155 (30%), Positives = 64/155 (41%), Gaps = 3/155 (1%)
Frame = +1
Query: 85 TQNVDGLHARAG--TKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
TQN+D L AG +L+E HG+ + C CK+ Y
Sbjct: 340 TQNIDTLERIAGIPANKLVEAHGSFATSHCVSCKKEYSTE---------------YVKER 384
Query: 259 IPVKLLPHCKKAH-CGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPA 435
I LP C + C +++P IV+FGESL + A + CD+ LV+GTS V+P
Sbjct: 385 IFKDELPECTETSGCKGIVKPDIVFFGESLPSRFNDCAREDFTKCDLLLVIGTSLKVHPF 444
Query: 436 AMFAPQAASRGAIVAEFNIEPTPANLISIFYFEGP 540
A A +G N E N F F P
Sbjct: 445 ASLINFA--KGCPRVLINFEEVGTNPYGGFKFNQP 477
>UniRef50_UPI00006CA40C Cluster: transcriptional regulator, Sir2
family protein; n=1; Tetrahymena thermophila SB210|Rep:
transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 471
Score = 56.0 bits (129), Expect = 7e-07
Identities = 43/146 (29%), Positives = 74/146 (50%), Gaps = 2/146 (1%)
Frame = +1
Query: 7 ANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKCK 180
+++T+ HF IA E N ++ I +QN+DGL AG +L++ HG+ +C CK
Sbjct: 278 SHFTSSHFFIA--ETNRRNRLLIN-FSQNIDGLELEAGLPESKLVQAHGHFRTAKCVNCK 334
Query: 181 EVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDIL 360
+V D + ++ + Y CK+ G +++P IV+FGESL
Sbjct: 335 KVA---DIELFNEAVKNDKICY------------CKECEEG-IVKPDIVFFGESLPQSFF 378
Query: 361 EAAEHAMSTCDVCLVVGTSSVVYPAA 438
+ + +++ D+ V+GTS V+P A
Sbjct: 379 QQID-SLNKADLVFVMGTSLKVFPFA 403
>UniRef50_UPI0000E49AD8 Cluster: PREDICTED: similar to NAD-dependent
deacetylase sirtuin 2 homolog; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to NAD-dependent
deacetylase sirtuin 2 homolog - Strongylocentrotus
purpuratus
Length = 400
Score = 55.6 bits (128), Expect = 9e-07
Identities = 37/120 (30%), Positives = 54/120 (45%), Gaps = 2/120 (1%)
Frame = +1
Query: 85 TQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
TQN+DGL AG + ++E HG+ + C C E+ R
Sbjct: 163 TQNIDGLDRMAGVPDELIMEAHGSFHTGHCLNCNEMYTEESM-------REK-------- 207
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
I L+P C K + +++P +V+FGESL CD+ +V+GTS VV P A
Sbjct: 208 IMADLIPRCAKCNETGVVKPDVVFFGESLPPRFPTLVSEDFPQCDLLIVMGTSLVVQPFA 267
>UniRef50_Q3F1F4 Cluster: SIR2 family protein; n=1; Bacillus
thuringiensis serovar israelensis ATCC 35646|Rep: SIR2
family protein - Bacillus thuringiensis serovar
israelensis ATCC 35646
Length = 241
Score = 55.6 bits (128), Expect = 9e-07
Identities = 43/137 (31%), Positives = 67/137 (48%), Gaps = 1/137 (0%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H +AK+E+ G K +VITQN+D H AG+K +IE+HG+L C C + D+
Sbjct: 78 HEILAKWEEQ-GKVK--SVITQNIDSYHKDAGSKNVIEMHGHLRNLVCDTCSK---EYDN 131
Query: 205 PICTCK*RSPRF*YGGFDIPVKLLPHC-KKAHCGALLRPHIVWFGESLEHDILEAAEHAM 381
+ T + + +C + C ++RP +V FGE+L A M
Sbjct: 132 SMYTKEDKD----------------NCGLEWECTGVVRPEVVLFGETLPPLAWHQANEQM 175
Query: 382 STCDVCLVVGTSSVVYP 432
D+ +V+GTS V+P
Sbjct: 176 KKTDLVIVLGTSLQVFP 192
>UniRef50_Q011Q8 Cluster: NAD-dependent deacetylase SIRT2; n=2;
Ostreococcus|Rep: NAD-dependent deacetylase SIRT2 -
Ostreococcus tauri
Length = 394
Score = 55.6 bits (128), Expect = 9e-07
Identities = 38/120 (31%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Frame = +1
Query: 85 TQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
TQN+D L G ++++ HGN C + E V D C+ +P
Sbjct: 192 TQNIDSLERATGLPKEKVVPAHGNFDGAHCLRGHEADV--DEVADACRAGTPMI------ 243
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
C K CG ++P IV+FGE+L E A+ CD+ +V+GTS VV+P A
Sbjct: 244 --------CSK--CGEYVKPDIVFFGENLPRRFFECAQEDFEVCDLLIVIGTSLVVHPFA 293
>UniRef50_UPI0000E49846 Cluster: PREDICTED: similar to Sirtuin
(silent mating type information regulation 2 homolog) 6
(S. cerevisiae); n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to Sirtuin (silent mating type
information regulation 2 homolog) 6 (S. cerevisiae) -
Strongylocentrotus purpuratus
Length = 521
Score = 54.8 bits (126), Expect = 2e-06
Identities = 46/168 (27%), Positives = 76/168 (45%), Gaps = 3/168 (1%)
Frame = +1
Query: 7 ANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAG--TKRLIELHGNLYKTRCTKCK 180
A TA H A+ + E Q +I+QN+DGLH R+G RL ELHGN++ +C +C+
Sbjct: 35 AKPTATHMALVELERRGKLQY---LISQNIDGLHLRSGFPKDRLAELHGNMFVEQCHRCR 91
Query: 181 EVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESL-EHDI 357
+ P+ T G + + C L I+ + ++L E D+
Sbjct: 92 RQTI-RAMPVPT---------LGLKPTGNRCSDKPGRGTCRGKLHDTILDWEDALPETDL 141
Query: 358 LEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
+A EH + D+ + +GTS + P+ G + N++PT
Sbjct: 142 TQAEEH-LRKSDLSICLGTSLQIIPSGTLPKLTKKNGGSLVIVNLQPT 188
>UniRef50_A1ZPG8 Cluster: NAD-dependent deacetylase; n=1;
Microscilla marina ATCC 23134|Rep: NAD-dependent
deacetylase - Microscilla marina ATCC 23134
Length = 278
Score = 54.8 bits (126), Expect = 2e-06
Identities = 49/163 (30%), Positives = 74/163 (45%), Gaps = 5/163 (3%)
Frame = +1
Query: 19 AGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCT-KCKEVL 189
AGH A+A E + ++ ITQN+D LH +AG +++E+HGN+ RC+ +C +
Sbjct: 89 AGHLALASTEVLLPNNFRL--ITQNIDRLHIKAGNTQAKVLEIHGNMETVRCSEECSMDV 146
Query: 190 VNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDIL--E 363
I T Y I + K CG+L+RP+++ F E + E
Sbjct: 147 YPFPLDIGTAP-------YDAKMI-TQQWEQLKCPDCGSLMRPNVLMFDEYYNERLYKQE 198
Query: 364 AAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNI 492
+A A V VVGTS A A RG+ + + NI
Sbjct: 199 SAIEAALNTGVLFVVGTSGATNLPHHIASTATYRGSSLVDINI 241
>UniRef50_A2DP91 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 267
Score = 54.4 bits (125), Expect = 2e-06
Identities = 41/144 (28%), Positives = 66/144 (45%), Gaps = 2/144 (1%)
Frame = +1
Query: 76 TVITQNVDGLHARAGTK-RLIELHGNLYKT-RCTKCKEVLVNNDSPICTCK*RSPRF*YG 249
T++TQN+D LH+ G + ++IELHG + + C KC N +P+ K
Sbjct: 100 TLLTQNIDSLHSFQGDESKIIELHGKVTEFGECEKC-----NRKTPVDHLK--------- 145
Query: 250 GFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVY 429
+ P C C + LRP + +F + + + + A T D+ +++GT VV
Sbjct: 146 --VLQSGKCPKCPV--CNSNLRPTVAFFQDLIPKALRQKATKICQTTDLLILIGTHCVVD 201
Query: 430 PAAMFAPQAASRGAIVAEFNIEPT 501
P +A GA V E N + T
Sbjct: 202 PVVTLVAEAFQSGATVVEINPDET 225
>UniRef50_Q5KDE0 Cluster: NAD-dependent histone deacetylase,
putative; n=2; Filobasidiella neoformans|Rep:
NAD-dependent histone deacetylase, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 413
Score = 54.4 bits (125), Expect = 2e-06
Identities = 43/143 (30%), Positives = 65/143 (45%), Gaps = 2/143 (1%)
Frame = +1
Query: 16 TAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKR--LIELHGNLYKTRCTKCKEVL 189
T H+ + F + H K+ V TQN+D L AG ++E HG+ C KC+ +
Sbjct: 142 TPTHYLLQLF-NRHNLLKR--VFTQNIDTLETLAGLPPHLIVEAHGSFATAHCLKCRREV 198
Query: 190 VNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAA 369
+ K + D +K + KK CG L++P IV+FGE L +
Sbjct: 199 DREE----VLKAGVRKGEVVRCDATLKAMGKGKK--CGGLVKPDIVFFGEGLPDRFFKLV 252
Query: 370 EHAMSTCDVCLVVGTSSVVYPAA 438
+ CD+ +V+GTS V P A
Sbjct: 253 PE-LRKCDLLIVIGTSLQVQPFA 274
>UniRef50_UPI0000D55B5A Cluster: PREDICTED: similar to CG5216-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG5216-PA - Tribolium castaneum
Length = 722
Score = 54.0 bits (124), Expect = 3e-06
Identities = 46/166 (27%), Positives = 74/166 (44%), Gaps = 11/166 (6%)
Frame = +1
Query: 40 KFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKC---------KEVLV 192
K +N+G K + TQN+D L A +++IE HG+ CTKC +E+++
Sbjct: 289 KMLENYG--KLLRNYTQNIDTLEKVANIEKVIECHGSFATATCTKCGHKVTADAIREIVL 346
Query: 193 NNDSPICT-CK*RSPRF*-YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEA 366
P+C C + + + + + G +++P IV+FGE L EA
Sbjct: 347 AQQIPLCEKCHPGKTSVPCIEEYKENSEEIDYRQLVSSG-IMKPDIVFFGEGLPDTFHEA 405
Query: 367 AEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTP 504
+ CD+ LV+G+S V P A+ P + N EP P
Sbjct: 406 MAQDKTECDLLLVIGSSLKVRPVALI-PSSLPPHVPQILINREPLP 450
>UniRef50_Q9I4E1 Cluster: NAD-dependent deacetylase 2; n=6;
Pseudomonadaceae|Rep: NAD-dependent deacetylase 2 -
Pseudomonas aeruginosa
Length = 256
Score = 54.0 bits (124), Expect = 3e-06
Identities = 47/143 (32%), Positives = 70/143 (48%), Gaps = 5/143 (3%)
Frame = +1
Query: 7 ANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKCK 180
A AGH AIA+ + + + + V+TQN+DG H +AG+ +RLIE+HG L C C
Sbjct: 84 ARPNAGHEAIAELQKH---KPECWVLTQNIDGFHRQAGSPAERLIEIHGELAPLYCQSC- 139
Query: 181 EVLVNNDSPICTCK*RSPRF*YGGFD--IPVKLLPHCKKAHCGALLRPHIVWFGESLEHD 354
+S GG + + +L P C A CG +LRP +V F E L +
Sbjct: 140 ----GAES--------------GGLEEHLHGQLPPRC--AACGGVLRPPVVLFEEMLPEE 179
Query: 355 ILEAAEHAM-STCDVCLVVGTSS 420
++ + D LVVGT++
Sbjct: 180 AIDTLYRELRKGFDAVLVVGTTA 202
>UniRef50_A1DG07 Cluster: SIR2 family histone deacetylase, putative;
n=3; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Neosartorya fischeri (strain
ATCC 1020 / DSM 3700 / NRRL 181)(Aspergillus
fischerianus (strain ATCC 1020 / DSM 3700 / NRRL 181))
Length = 425
Score = 53.2 bits (122), Expect = 5e-06
Identities = 40/139 (28%), Positives = 57/139 (41%), Gaps = 2/139 (1%)
Frame = +1
Query: 85 TQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
TQN+D L AG ++++E HG+ C CK K
Sbjct: 125 TQNIDCLERLAGVPGEKIVEAHGSFASQHCIDCKAAYPEPQMKEAIAKGE---------- 174
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
+PHC HC ++P IV+FGE+L + A D+C+V+GTS V+P A
Sbjct: 175 -----VPHCP--HCNGFVKPDIVFFGEALPEE-FHANRSLPEQADLCIVMGTSLTVHPFA 226
Query: 439 MFAPQAASRGAIVAEFNIE 495
P G N+E
Sbjct: 227 SL-PSFCREGVPRVLINME 244
>UniRef50_Q885X7 Cluster: NAD-dependent deacetylase 2; n=4;
Pseudomonas|Rep: NAD-dependent deacetylase 2 -
Pseudomonas syringae pv. tomato
Length = 248
Score = 53.2 bits (122), Expect = 5e-06
Identities = 52/164 (31%), Positives = 76/164 (46%), Gaps = 5/164 (3%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVLVNN 198
H+AIA+ + + + V+TQNVDG H AG+ +RLIE+HG L C C
Sbjct: 84 HYAIAQLQR---IKPECWVLTQNVDGYHRAAGSPPERLIEIHGQLSPLFCQSCAA----- 135
Query: 199 DSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHA 378
+ P+ + L P C+ CG +LRP +V F E L LE
Sbjct: 136 ---------QDPQL---SEHLQRPLPPLCRL--CGGILRPPVVLFQEMLPERALETLYEQ 181
Query: 379 MST-CDVCLVVGTSSVVYPAAMFAPQAASR--GAIVAEFNIEPT 501
++T D L +GT++ +P + P +R G AE N +PT
Sbjct: 182 LATGYDAVLSIGTTA-SFP-YIHEPVIRTRVSGGFTAEINPQPT 223
>UniRef50_UPI0000F1D51E Cluster: PREDICTED: hypothetical protein;
n=1; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 504
Score = 52.8 bits (121), Expect = 6e-06
Identities = 21/44 (47%), Positives = 28/44 (63%)
Frame = +1
Query: 274 LPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLV 405
L C++ C LLRPH+VWFGE+L+ IL E + TCD+ V
Sbjct: 166 LERCEQKACDGLLRPHVVWFGETLDSHILTKVEKELETCDLSAV 209
>UniRef50_A2F8N6 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 320
Score = 52.8 bits (121), Expect = 6e-06
Identities = 40/138 (28%), Positives = 65/138 (47%), Gaps = 2/138 (1%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVLVNN 198
HF +AK +NHG + +QN+DGL AG + L+E HG L K C KC + +
Sbjct: 109 HF-LAKLFENHGIL--LRHYSQNIDGLDKAAGLSEEHLVEWHGTLSKATCRKCSKKYTLD 165
Query: 199 DSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHA 378
D P+ I + +P C CG +++P ++ +G+ + D+ +
Sbjct: 166 DI--------KPK-------ILAEAVPRCS---CGGVIQPDVMLYGDYNDDDLYTHLDKD 207
Query: 379 MSTCDVCLVVGTSSVVYP 432
+ D+ V+GTS V P
Sbjct: 208 VEQADLLFVLGTSLKVEP 225
>UniRef50_Q96EB6 Cluster: NAD-dependent deacetylase sirtuin-1; n=29;
Euteleostomi|Rep: NAD-dependent deacetylase sirtuin-1 -
Homo sapiens (Human)
Length = 747
Score = 52.8 bits (121), Expect = 6e-06
Identities = 40/140 (28%), Positives = 61/140 (43%)
Frame = +1
Query: 85 TQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFDIP 264
TQN+D L AG +R+I+ HG+ C CK + C+ F+
Sbjct: 344 TQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKV--------DCEAVRGDI----FNQV 391
Query: 265 VKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMF 444
V P C A+++P IV+FGE+L A ++ D+ +V+G+S V P A+
Sbjct: 392 VPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALI 451
Query: 445 APQAASRGAIVAEFNIEPTP 504
P + N EP P
Sbjct: 452 -PSSIPHEVPQILINREPLP 470
>UniRef50_UPI000051AA14 Cluster: PREDICTED: similar to NAD-dependent
deacetylase sirtuin-1 (hSIRT1) (hSIR2) (SIR2-like
protein 1); n=1; Apis mellifera|Rep: PREDICTED: similar
to NAD-dependent deacetylase sirtuin-1 (hSIRT1) (hSIR2)
(SIR2-like protein 1) - Apis mellifera
Length = 868
Score = 52.4 bits (120), Expect = 9e-06
Identities = 38/126 (30%), Positives = 60/126 (47%)
Frame = +1
Query: 64 QKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF* 243
+K + +QN+D L AG + +IE HG+ CT+CK + +D R
Sbjct: 287 KKLLRNYSQNIDTLEQVAGIENVIECHGSFATASCTRCKYQVKADDI-------RE---- 335
Query: 244 YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSV 423
DI + +P C K +++P IV+FGE L +A CD+ +V+G+S
Sbjct: 336 ----DIFSQRIPLCPKC----IMKPDIVFFGEGLPDAFHDAMAKDKDECDLLIVIGSSLK 387
Query: 424 VYPAAM 441
V P A+
Sbjct: 388 VRPVAL 393
>UniRef50_Q4WFZ3 Cluster: SIR2 family histone deacetylase, putative;
n=4; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Aspergillus fumigatus (Sartorya
fumigata)
Length = 403
Score = 52.4 bits (120), Expect = 9e-06
Identities = 39/132 (29%), Positives = 60/132 (45%), Gaps = 2/132 (1%)
Frame = +1
Query: 79 VITQNVDGLHARAGTK--RLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGG 252
V TQN+DGL G +++ HG+ RC KCK ++
Sbjct: 180 VFTQNIDGLERDVGIPEDKILNAHGSWRTQRCWKCKTPYPDDLMKQA------------- 226
Query: 253 FDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYP 432
I +P+C+ CG ++P IV+FG+ L + + E +S D+ LV+GTS V P
Sbjct: 227 --ISTGTVPYCQVPDCGGAVKPDIVFFGQPLPAE-FDEKEKEVSEADMMLVMGTSLKVAP 283
Query: 433 AAMFAPQAASRG 468
+ P+ A G
Sbjct: 284 CSRL-PRLAREG 294
>UniRef50_O94066 Cluster: Transcription regulatory protein; n=6;
Saccharomycetales|Rep: Transcription regulatory protein
- Candida albicans (Yeast)
Length = 331
Score = 52.4 bits (120), Expect = 9e-06
Identities = 45/147 (30%), Positives = 64/147 (43%), Gaps = 8/147 (5%)
Frame = +1
Query: 22 GHFAIAKFE------DNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKC 177
G+FA KF + GS K+ V TQN+D L AG K ++E HG+ C C
Sbjct: 83 GNFAPTKFHHFIKLLQDQGSLKR--VYTQNIDTLERLAGVEDKYIVEAHGSFASNHCVDC 140
Query: 178 KEVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDI 357
+ + T K + K +P C+ HC ++P IV+FGE L
Sbjct: 141 HKEMTTE-----TLK----------TYMKDKKIPSCQ--HCEGYVKPDIVFFGEGLPVKF 183
Query: 358 LEAAEHAMSTCDVCLVVGTSSVVYPAA 438
+ E +V +V GTS V+P A
Sbjct: 184 FDLWEDDCEDVEVAIVAGTSLTVFPFA 210
>UniRef50_Q9FE17 Cluster: Sir2-like protein; n=9; Magnoliophyta|Rep:
Sir2-like protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 473
Score = 52.0 bits (119), Expect = 1e-05
Identities = 42/145 (28%), Positives = 64/145 (44%), Gaps = 3/145 (2%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKR--LIELHGNLYKTRCTKC-KEVLVNNDSPICTCK*RSPRF*YG 249
VI+QNVDGLH R+G R L ELHG+ + C C E L + + K S +
Sbjct: 111 VISQNVDGLHLRSGIPREKLSELHGDSFMEMCPSCGAEYLRDFEVETIGLKETSRK---- 166
Query: 250 GFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVY 429
C CGA L+ ++ + ++L ++ AE D+ L +GTS +
Sbjct: 167 -----------CSVEKCGAKLKDTVLDWEDALPPKEIDPAEKHCKKADLVLCLGTSLQIT 215
Query: 430 PAAMFAPQAASRGAIVAEFNIEPTP 504
PA + G + N++ TP
Sbjct: 216 PACNLPLKCLKGGGKIVIVNLQKTP 240
>UniRef50_Q75DM1 Cluster: ABL004Wp; n=1; Eremothecium gossypii|Rep:
ABL004Wp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 319
Score = 52.0 bits (119), Expect = 1e-05
Identities = 30/77 (38%), Positives = 44/77 (57%), Gaps = 3/77 (3%)
Frame = +1
Query: 274 LPHCKKAHCGALLRPHIVWFGESL---EHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMF 444
LP C + G LLRP +VW GESL + D ++A A D+ LV+GTS ++PA +
Sbjct: 202 LPRCPRCRVG-LLRPGVVWCGESLSLVQMDRVDAFLSAKQKVDLVLVIGTSGRLWPAMGY 260
Query: 445 APQAASRGAIVAEFNIE 495
+A G+ +A FN +
Sbjct: 261 VERAQLCGSRIAFFNTD 277
Score = 49.6 bits (113), Expect = 6e-05
Identities = 26/61 (42%), Positives = 39/61 (63%), Gaps = 4/61 (6%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGS--QKKITVITQNVDGLHARAGTKR--LIELHGNLYKTRCT 171
KA GHFA+A+ + +++I ++TQNVDGLH RAG +ELHG+++ RCT
Sbjct: 79 KARPNNGHFALAELCRRVAADERREILLVTQNVDGLHWRAGQPEASTVELHGSVFDYRCT 138
Query: 172 K 174
+
Sbjct: 139 E 139
>UniRef50_Q9NRC8 Cluster: NAD-dependent deacetylase sirtuin-7; n=24;
Eumetazoa|Rep: NAD-dependent deacetylase sirtuin-7 -
Homo sapiens (Human)
Length = 400
Score = 52.0 bits (119), Expect = 1e-05
Identities = 59/194 (30%), Positives = 83/194 (42%), Gaps = 13/194 (6%)
Frame = +1
Query: 1 AKANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKR--LIELHGNLYKTRCTK 174
++A T H +I + + Q V++QN DGLH R+G R + ELHGN+Y CT
Sbjct: 141 SEAEPTLTHMSITRLHEQKLVQH---VVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTS 197
Query: 175 CKEVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPH----CKKAH-CGALLRPHIVWFGE 339
C V N + FD+ + H + H CG LR IV FGE
Sbjct: 198 C----VPNREYVRV------------FDVTERTALHRHQTGRTCHKCGTQLRDTIVHFGE 241
Query: 340 --SLEHDI-LEAAEHAMSTCDVCLVVGTSSVV---YPAAMFAPQAASRGAIVAEFNIEPT 501
+L + EAA A S D L +G+S V YP + SR + N++ T
Sbjct: 242 RGTLGQPLNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWT 301
Query: 502 PANLISIFYFEGPC 543
P + + G C
Sbjct: 302 PKDDWAALKLHGKC 315
>UniRef50_UPI00015B57C0 Cluster: PREDICTED: similar to GA18743-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
GA18743-PA - Nasonia vitripennis
Length = 871
Score = 51.6 bits (118), Expect = 1e-05
Identities = 39/136 (28%), Positives = 62/136 (45%), Gaps = 10/136 (7%)
Frame = +1
Query: 64 QKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND---------SPIC- 213
+K + +QN+D L AG LIE HG+ CTKCK + ++D P+C
Sbjct: 288 KKLLRNYSQNIDTLERVAGINNLIECHGSFATASCTKCKYQVKSDDVKAEIFAQTIPMCP 347
Query: 214 TCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCD 393
C+ +S P + + +++P IV+FGE L +A CD
Sbjct: 348 KCQEQS----LPSITDPTS-SDNYRDIVAQGVMKPDIVFFGEGLPDAFHDAMASDKDVCD 402
Query: 394 VCLVVGTSSVVYPAAM 441
+ +V+G+S V P A+
Sbjct: 403 LLIVIGSSLKVRPVAL 418
>UniRef50_Q7PS76 Cluster: ENSANGP00000025231; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000025231 - Anopheles gambiae
str. PEST
Length = 182
Score = 51.6 bits (118), Expect = 1e-05
Identities = 42/135 (31%), Positives = 70/135 (51%), Gaps = 1/135 (0%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKIT-VITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNND 201
H+ +A+ E + +I+ ++TQNVD LH +AG+K++IELHG+ + T + + D
Sbjct: 69 HYTLARLE----REGRISGIVTQNVDRLHGKAGSKQVIELHGSGFDDNSTSMRP---DGD 121
Query: 202 SPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAM 381
+ S + GF I P C + CG L+P IV+FG+++ +E +
Sbjct: 122 VEL------SMEY-VQGFKI-----PPCPQ--CGGNLKPEIVFFGDNVPMPRIEKVVRMI 167
Query: 382 STCDVCLVVGTSSVV 426
D LV+G+S V
Sbjct: 168 IESDGVLVLGSSLTV 182
>UniRef50_Q22ZC3 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 308
Score = 51.6 bits (118), Expect = 1e-05
Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 2/121 (1%)
Frame = +1
Query: 82 ITQNVDGLHARAG--TKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGF 255
ITQN+DGL + G ++++ HG++ K C C + VN ++ + C
Sbjct: 157 ITQNIDGLELKTGINPSKVVQAHGHMRKAHCVNCNHI-VNIETYLQNC------------ 203
Query: 256 DIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPA 435
K L + C L++P IV+FGE L ++ ++ + + D +V+GTS V+P
Sbjct: 204 ----KQLKKTQCPICNNLVKPKIVFFGEFLPNEFYQSRD-ILPNSDCVVVMGTSLGVFPF 258
Query: 436 A 438
A
Sbjct: 259 A 259
>UniRef50_A2F9H1 Cluster: Transcriptional regulator, Sir2 family
protein; n=2; Trichomonas vaginalis|Rep: Transcriptional
regulator, Sir2 family protein - Trichomonas vaginalis
G3
Length = 304
Score = 51.6 bits (118), Expect = 1e-05
Identities = 38/120 (31%), Positives = 54/120 (45%), Gaps = 2/120 (1%)
Frame = +1
Query: 85 TQNVDGLHARAGTK--RLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
TQN+DGL AG +L+E HG CT+CK+ + + G
Sbjct: 114 TQNIDGLERIAGVPEDKLVESHGTFSTAHCTECKKEWKLEEI--------RDKLLLGK-- 163
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
P+ HC C ++P IV+FGE+L A + +CD+ L+ GTS V P A
Sbjct: 164 -PL----HCTDPDCKGFIKPDIVFFGENLPTSFQHNARIDLRSCDMLLISGTSLKVNPFA 218
>UniRef50_Q88ZA0 Cluster: NAD-dependent deacetylase; n=4;
Lactobacillus|Rep: NAD-dependent deacetylase -
Lactobacillus plantarum
Length = 234
Score = 51.6 bits (118), Expect = 1e-05
Identities = 21/38 (55%), Positives = 28/38 (73%)
Frame = +1
Query: 64 QKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKC 177
Q + +VITQN+D L+ A T +L+E HGNLY+ CTKC
Sbjct: 91 QGRASVITQNIDNLYGVAKTAQLVEFHGNLYQVYCTKC 128
Score = 34.3 bits (75), Expect = 2.4
Identities = 19/63 (30%), Positives = 31/63 (49%)
Frame = +1
Query: 310 LRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFN 489
LRP++V + E + +E A + D+ ++ GTS VYP A + ++A N
Sbjct: 150 LRPNVVLYDEGIASANIERAVQYLQQADLVVICGTSFRVYPFAGLIDYRNPKAQVLA-IN 208
Query: 490 IEP 498
EP
Sbjct: 209 AEP 211
>UniRef50_Q8FUC8 Cluster: NAD-dependent deacetylase 1; n=6;
Corynebacterium|Rep: NAD-dependent deacetylase 1 -
Corynebacterium efficiens
Length = 281
Score = 51.6 bits (118), Expect = 1e-05
Identities = 48/159 (30%), Positives = 70/159 (44%), Gaps = 15/159 (9%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKC-----KEVL------VNN---DSPICT 216
++TQNVDGLH RAG++ L+ LHG+L C +C +E+L +N DS
Sbjct: 99 IVTQNVDGLHRRAGSENLVALHGDLATIVCLQCGHREARELLDARLDHLNPGYFDSIALD 158
Query: 217 CK*RSPRF*YGGFDIPVKLLPHCKKAHCGA-LLRPHIVWFGESLEHDILEAAEHAMSTCD 393
+P D V+ A CG+ LL+P +V+FGE + + D
Sbjct: 159 PSAVNPDGDVTLDDHHVQRFTMAGCARCGSVLLKPDVVYFGEPVPSIRKTRVAQLLDGAD 218
Query: 394 VCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPAN 510
+V G+S V +A G VA N P A+
Sbjct: 219 AVVVAGSSLAVMSGYRIVIEAQRAGKPVAVINGGPGRAD 257
>UniRef50_A0DQW0 Cluster: Chromosome undetermined scaffold_6, whole
genome shotgun sequence; n=3; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_6,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 367
Score = 50.8 bits (116), Expect = 3e-05
Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 2/162 (1%)
Frame = +1
Query: 19 AGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNN 198
AGH AIA ++ + + +++QN+D + ++ I+ HG+ Y++ +
Sbjct: 190 AGHIAIANYKKKNPNT---LIVSQNIDNILTSILPQKQIK-HGH-YESIYEIHGNIKYMR 244
Query: 199 DSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESL--EHDILEAAE 372
S CT + Y D+ L P C K CG RPHI++F ES E+ ++ +
Sbjct: 245 CSKECTLEKDQLAILYDMPDLTKNLRPKCPK--CGEDARPHILFFDESYTNENCRIQELQ 302
Query: 373 HAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEP 498
T D +VVGT A + + AI+ E N EP
Sbjct: 303 EKYETYDTIIVVGTMLETGCAKSTVCKFIKKKAIIIEINPEP 344
>UniRef50_Q54P49 Cluster: Zn finger-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: Zn finger-containing
protein - Dictyostelium discoideum AX4
Length = 456
Score = 50.4 bits (115), Expect = 3e-05
Identities = 42/121 (34%), Positives = 60/121 (49%), Gaps = 4/121 (3%)
Frame = +1
Query: 88 QNVDGLHARAGTK--RLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFDI 261
QN D L AG +LIE HG+ +RCT C L + I + F +
Sbjct: 274 QNADTLERIAGIPLDKLIEAHGSFAVSRCTNCG--LEYSQEYI-----KDSIF----NND 322
Query: 262 PVK-LLPHCKKAHCG-ALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPA 435
P+K ++P CK C A+++P IV+FGESL + ++ CD +V+GTS V P
Sbjct: 323 PLKSVVPRCKVVQCNNAVIKPDIVFFGESLPPIFNQNILDDINRCDCLIVIGTSLKVQPI 382
Query: 436 A 438
A
Sbjct: 383 A 383
>UniRef50_A7EC18 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 446
Score = 50.4 bits (115), Expect = 3e-05
Identities = 42/123 (34%), Positives = 62/123 (50%), Gaps = 2/123 (1%)
Frame = +1
Query: 79 VITQNVDGLHARAG--TKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGG 252
+ TQN+D L RAG ++++IE HG+ RC CK + P K + G
Sbjct: 124 LFTQNIDCLERRAGVSSEKVIEAHGSFATQRCIDCK-----TEYPDDMMK----KAIQEG 174
Query: 253 FDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYP 432
D L+P C G L++P IV+FGE L + + + +T D+ +V+GTS V P
Sbjct: 175 -DPATCLVPQC-----GGLVKPDIVFFGEQLP-EAFHSHKMIPATADLIIVMGTSLSVQP 227
Query: 433 AAM 441
AM
Sbjct: 228 FAM 230
>UniRef50_O59923 Cluster: NAD-dependent histone deacetylase SIR2;
n=3; Candida albicans|Rep: NAD-dependent histone
deacetylase SIR2 - Candida albicans (Yeast)
Length = 515
Score = 50.4 bits (115), Expect = 3e-05
Identities = 41/140 (29%), Positives = 62/140 (44%), Gaps = 2/140 (1%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTK--RLIELHGNLYKTRCTKCKEVLVNN 198
H + +D H K + TQN+D L RAG K +L++ HG+ K +C C+ +
Sbjct: 306 HAFLKLLQDKH---KLLRNYTQNIDNLEQRAGLKSEKLVQCHGSFAKAKCVSCQGIFAGE 362
Query: 199 DSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHA 378
+ + PR + K P H GA ++P I +FGE L +
Sbjct: 363 KIYNHIRRKQVPRCAICWKN--TKQAP----IHFGA-IKPTITFFGEDLPERFHTLMDKD 415
Query: 379 MSTCDVCLVVGTSSVVYPAA 438
+ D+ LV+GTS V P A
Sbjct: 416 LQQIDLFLVIGTSLKVEPVA 435
>UniRef50_Q9VH08 Cluster: CG6284-PA; n=9; Eumetazoa|Rep: CG6284-PA -
Drosophila melanogaster (Fruit fly)
Length = 317
Score = 50.0 bits (114), Expect = 5e-05
Identities = 43/158 (27%), Positives = 71/158 (44%), Gaps = 6/158 (3%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKR--LIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGG 252
VI+QN+DGLH ++G R L ELHGN+Y +C KC+ V+ + + R
Sbjct: 110 VISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKCRRQFVSPSAVETVGQKSLQRACKSS 169
Query: 253 FDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYP 432
D + C+ G L + W + E+D+ H+ + D+ + +GT+ + P
Sbjct: 170 MDSKGR---SCRS---GILYDNVLDWEHDLPENDLEMGVMHS-TVADLNIALGTTLQIVP 222
Query: 433 AAMFAPQAASRGAIVAEFNIEPT----PANLISIFYFE 534
+ + G N++PT ANLI Y +
Sbjct: 223 SGDLPLKNLKCGGKFVICNLQPTKHDKKANLIISSYVD 260
>UniRef50_Q7SCL4 Cluster: Putative uncharacterized protein NCU00523.1;
n=2; Pezizomycotina|Rep: Putative uncharacterized protein
NCU00523.1 - Neurospora crassa
Length = 1220
Score = 50.0 bits (114), Expect = 5e-05
Identities = 39/122 (31%), Positives = 56/122 (45%), Gaps = 2/122 (1%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKR--LIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGG 252
+ TQN+D L AG ++E HG+ RC CK +P K R
Sbjct: 965 LFTQNIDCLERAAGVPADLIVEAHGSFASQRCIDCK-------TPYPDDKMRE------- 1010
Query: 253 FDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYP 432
+ +PHC+K C L++P IV+F E+L + H D+ LV+GTS V+P
Sbjct: 1011 -HVSRAEVPHCEK--CNGLVKPDIVFFHENLPSLFFDR-RHMAEEADLILVLGTSLTVHP 1066
Query: 433 AA 438
A
Sbjct: 1067 FA 1068
>UniRef50_A6RXY5 Cluster: Putative uncharacterized protein; n=2;
Pezizomycotina|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 446
Score = 50.0 bits (114), Expect = 5e-05
Identities = 45/134 (33%), Positives = 65/134 (48%), Gaps = 5/134 (3%)
Frame = +1
Query: 79 VITQNVDGLHARAG--TKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGG 252
+ TQN+D L RAG ++++IE HG+ RC CK + P K + G
Sbjct: 124 LFTQNIDCLERRAGVSSEKVIEAHGSFATQRCIDCK-----TEYPDDMMK----KAIEDG 174
Query: 253 FDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYP 432
D L+P C G L++P IV+FGE L + A + +T D+ +V+GTS V P
Sbjct: 175 -DPATCLVPQC-----GGLVKPDIVFFGEQLP-EAFHANKMIPATADLVIVMGTSLSVQP 227
Query: 433 AA---MFAPQAASR 465
A AP+ R
Sbjct: 228 FATLPTLAPETVPR 241
>UniRef50_Q8R104 Cluster: NAD-dependent deacetylase sirtuin-3; n=8;
Deuterostomia|Rep: NAD-dependent deacetylase sirtuin-3 -
Mus musculus (Mouse)
Length = 257
Score = 50.0 bits (114), Expect = 5e-05
Identities = 38/131 (29%), Positives = 59/131 (45%), Gaps = 3/131 (2%)
Frame = +1
Query: 55 HGSQKKITVITQNVDGLHARAG--TKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*R 228
H + + + TQN+DGL +G +L+E HG CT C+ D
Sbjct: 75 HDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDI-------- 126
Query: 229 SPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESL-EHDILEAAEHAMSTCDVCLV 405
D+ +P C C +++P IV+FGE L +L A+ A++ D+ L+
Sbjct: 127 -------WADVMADRVPRCPV--CTGVVKPDIVFFGEQLPARFLLHMADFALA--DLLLI 175
Query: 406 VGTSSVVYPAA 438
+GTS V P A
Sbjct: 176 LGTSLEVEPFA 186
>UniRef50_O96505 Cluster: SIR2; n=4; Sophophora|Rep: SIR2 -
Drosophila melanogaster (Fruit fly)
Length = 823
Score = 49.6 bits (113), Expect = 6e-05
Identities = 37/129 (28%), Positives = 58/129 (44%), Gaps = 11/129 (8%)
Frame = +1
Query: 85 TQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS----------PICT-CK*RS 231
TQN+D L AG +R+IE HG+ CTKC+ N D+ P+C C+
Sbjct: 312 TQNIDTLERVAGIQRVIECHGSFSTASCTKCR-FKCNADALRADIFAQRIPVCPQCQPNK 370
Query: 232 PRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVG 411
+ + + L + +++P IV+FGE L + CD+ +V+G
Sbjct: 371 EQSVDASVAVTEEELRQLVE---NGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIG 427
Query: 412 TSSVVYPAA 438
+S V P A
Sbjct: 428 SSLKVRPVA 436
>UniRef50_Q25337 Cluster: NAD-dependent deacetylase SIR2 homolog;
n=6; Leishmania|Rep: NAD-dependent deacetylase SIR2
homolog - Leishmania major
Length = 381
Score = 49.6 bits (113), Expect = 6e-05
Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 2/144 (1%)
Frame = +1
Query: 16 TAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVL 189
TA H I +D + + TQN+DGL AG + L+E HG+ C +C
Sbjct: 103 TAVHHFIRLLQDEG---RLLRCCTQNIDGLEKAAGVSPELLVEAHGSFAAAACIECHTPF 159
Query: 190 VNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAA 369
+ + + + C CG +++P++V+FGE+L +A
Sbjct: 160 SIEQNYL---------------EAMSGTVSRCST--CGGIVKPNVVFFGENLPDAFFDAL 202
Query: 370 EHAMSTCDVCLVVGTSSVVYPAAM 441
H ++ +++GTS V+P A+
Sbjct: 203 HHDAPIAELVIIIGTSMQVHPFAL 226
>UniRef50_UPI00004997CB Cluster: Sir2 family transcriptional
regulator; n=2; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 346
Score = 49.2 bits (112), Expect = 8e-05
Identities = 37/120 (30%), Positives = 54/120 (45%), Gaps = 2/120 (1%)
Frame = +1
Query: 79 VITQNVDGLHARAG--TKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGG 252
+ TQN+DGL ++G ++L+ HGN Y C KCK+ F
Sbjct: 192 LFTQNIDGLEIQSGFPNEKLVMAHGNYYSGHCLKCKK-----------------SFKQSY 234
Query: 253 FDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYP 432
F V+ C C L++P IV+FGE L E + CD+ +V+GTS + P
Sbjct: 235 FIDNVRDGKVCYCDSCKGLVKPDIVFFGEGLPQQFFNNFE-KVEECDLLIVLGTSLLNTP 293
>UniRef50_A5AF92 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 343
Score = 49.2 bits (112), Expect = 8e-05
Identities = 41/142 (28%), Positives = 64/142 (45%), Gaps = 3/142 (2%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKR--LIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGG 252
VI+QN+DGLH R+G R L ELHGN + C+ C + D + + +
Sbjct: 142 VISQNIDGLHLRSGIPRDKLAELHGNSFMEICSSCG---IEYDFNL---------YLHLV 189
Query: 253 FDIPVK-LLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVY 429
I +K C CGA LR ++ + ++L + AE DV L +GTS +
Sbjct: 190 ETIGLKETSRRCSNVDCGAKLRDTVLDWEDALPPKEMNPAEKHCRMADVVLCLGTSLQIT 249
Query: 430 PAAMFAPQAASRGAIVAEFNIE 495
PA ++ G + N++
Sbjct: 250 PACNLPLKSLRGGGKIVIVNLQ 271
>UniRef50_Q6FKU1 Cluster: Similar to sp|P53686 Saccharomyces
cerevisiae YPL015c; n=3; Saccharomycetales|Rep: Similar
to sp|P53686 Saccharomyces cerevisiae YPL015c - Candida
glabrata (Yeast) (Torulopsis glabrata)
Length = 364
Score = 49.2 bits (112), Expect = 8e-05
Identities = 39/145 (26%), Positives = 65/145 (44%), Gaps = 7/145 (4%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKR--LIELHGNLYKTRCTKCKEVLVNN 198
H+ + E N G ++ V TQN+D L AG L+E HG+ K C C + +
Sbjct: 89 HYLMKVLEKN-GRLRR--VYTQNIDTLEREAGIPDDYLVEAHGSFAKNHCIGCDKEFPLD 145
Query: 199 DSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHA 378
D + + + +K + + C AL++P IV+FGE+L ++ +
Sbjct: 146 DFKKALLRYNKYKMKHNN---DMKEFEYLRCPECEALIKPKIVFFGENLPKRFFDSWDTD 202
Query: 379 MSTCD-----VCLVVGTSSVVYPAA 438
+ + + +V GTS VYP A
Sbjct: 203 LEWLEEESNSIVIVAGTSLTVYPFA 227
>UniRef50_A1CD03 Cluster: SIR2 family histone deacetylase, putative;
n=2; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Aspergillus clavatus
Length = 329
Score = 49.2 bits (112), Expect = 8e-05
Identities = 34/127 (26%), Positives = 57/127 (44%), Gaps = 2/127 (1%)
Frame = +1
Query: 79 VITQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGG 252
+ TQN+DGL G +++ HG+ C KCK ++ K
Sbjct: 104 LFTQNIDGLERDTGVPENKILNAHGSWRTQHCWKCKTSYPDDLMKEAIAK---------- 153
Query: 253 FDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYP 432
++P+C+ CG ++P +V+FG+SL + E E + D+ +V+GTS V P
Sbjct: 154 -----GVVPYCQVPDCGGPIKPDVVFFGQSLPAE-FEDEEKKVPEADLMIVMGTSLKVAP 207
Query: 433 AAMFAPQ 453
+ Q
Sbjct: 208 CSRLPGQ 214
>UniRef50_Q4DP02 Cluster: Silent information regulator 2, putative;
n=4; Trypanosoma|Rep: Silent information regulator 2,
putative - Trypanosoma cruzi
Length = 359
Score = 48.8 bits (111), Expect = 1e-04
Identities = 36/123 (29%), Positives = 60/123 (48%), Gaps = 2/123 (1%)
Frame = +1
Query: 85 TQNVDGLHARAGTKR--LIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
TQN+DGL +G L+E HG+ C +C+ D + + + R +
Sbjct: 121 TQNIDGLERASGLPMSFLVEAHGSFSTASCIECRSPY---DIELASRESREGK------- 170
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
+PHC + CG +++P +V+FGESL D ++ ++ L++GTS V+P A
Sbjct: 171 -----VPHCDR--CGGVVKPDVVFFGESLP-DAFFNVFAEITEVELLLIMGTSLQVHPFA 222
Query: 439 MFA 447
A
Sbjct: 223 ELA 225
>UniRef50_Q23E36 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 1348
Score = 48.8 bits (111), Expect = 1e-04
Identities = 43/145 (29%), Positives = 70/145 (48%), Gaps = 2/145 (1%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKC 177
K ++T+ H+ +A E N Q + V +QNVDGL AG ++L ++HGN RC KC
Sbjct: 85 KPHFTSAHYFMA--EVNRREQL-LFVFSQNVDGLELEAGLPPEKLCQVHGNYRGARCQKC 141
Query: 178 KEVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDI 357
N Y F + +++ C+ G +RP++V+FGESL+
Sbjct: 142 GFKHDINK--------------YKEF-VQKQVIYKCENCKRGP-VRPNVVFFGESLDKGF 185
Query: 358 LEAAEHAMSTCDVCLVVGTSSVVYP 432
+ + ++ D ++GTS V P
Sbjct: 186 TKNT-YKIAAADCVFIMGTSMQVAP 209
>UniRef50_A7AWG1 Cluster: Transcriptional regulator, Sir2 family
domain containing protein; n=2; Babesia bovis|Rep:
Transcriptional regulator, Sir2 family domain containing
protein - Babesia bovis
Length = 656
Score = 48.8 bits (111), Expect = 1e-04
Identities = 44/127 (34%), Positives = 57/127 (44%), Gaps = 3/127 (2%)
Frame = +1
Query: 76 TVITQNVDGLHARAGTK--RLIELHGNLYKTRCTKC-KEVLVNNDSPICTCK*RSPRF*Y 246
TVITQN+DGLHA +G K IELHGN++ RC C + L +P + K P +
Sbjct: 139 TVITQNIDGLHAISGMKHSECIELHGNVFIERCIFCARRYLRPYVAPTISFK---PTGSH 195
Query: 247 GGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVV 426
G C G L + WF +H A HA D L +G+S V
Sbjct: 196 CGL---------CNFPPYGILTDVVLDWFDRYEDHFEKRAISHA-EEADFHLTLGSSLHV 245
Query: 427 YPAAMFA 447
PA +A
Sbjct: 246 EPACCYA 252
>UniRef50_A0C6J0 Cluster: Chromosome undetermined scaffold_152,
whole genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_152,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 449
Score = 48.8 bits (111), Expect = 1e-04
Identities = 39/135 (28%), Positives = 62/135 (45%), Gaps = 2/135 (1%)
Frame = +1
Query: 40 KFEDNHGSQKKITVITQNVDGLHARAGTK--RLIELHGNLYKTRCTKCKEVLVNNDSPIC 213
KF D+ G K TQN+DGL AG ++I+ HG++ RC +C+E + D
Sbjct: 287 KFLDSRGQLLKC--FTQNIDGLELDAGVSQDKVIQAHGHMRTARCIECQEEVSIKDFM-- 342
Query: 214 TCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCD 393
I + C+K L++P +V+FGE L + + + + D
Sbjct: 343 -------------SHIKKGDIHRCEKCPKKGLVKPDVVFFGEGLPGEFF-YSWNCLKDAD 388
Query: 394 VCLVVGTSSVVYPAA 438
+ +V+GTS V P A
Sbjct: 389 LLIVIGTSLKVMPFA 403
>UniRef50_Q8IXJ6 Cluster: NAD-dependent deacetylase sirtuin-2; n=31;
Coelomata|Rep: NAD-dependent deacetylase sirtuin-2 -
Homo sapiens (Human)
Length = 389
Score = 48.8 bits (111), Expect = 1e-04
Identities = 38/126 (30%), Positives = 58/126 (46%), Gaps = 2/126 (1%)
Frame = +1
Query: 85 TQNVDGLHARAGTKR--LIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
TQN+D L AG ++ L+E HG Y + C ++ P+ K +
Sbjct: 166 TQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSAS---CRHEYPLSWMKEK---------- 212
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
I ++ P C+ C +L++P IV+FGESL + D+ LV+GTS V P A
Sbjct: 213 IFSEVTPKCED--CQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFA 270
Query: 439 MFAPQA 456
+A
Sbjct: 271 SLISKA 276
>UniRef50_Q9JN05 Cluster: NAD-dependent deacetylase; n=13;
Campylobacter|Rep: NAD-dependent deacetylase -
Campylobacter jejuni
Length = 233
Score = 48.8 bits (111), Expect = 1e-04
Identities = 25/54 (46%), Positives = 34/54 (62%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEV 186
H IA+ ++ G K + VITQNVD L RAG K ++ LHG L + RC KC+ +
Sbjct: 69 HEKIAQLKEKWG--KNLFVITQNVDDLLERAGCKDVVHLHGFLPELRCLKCEGI 120
>UniRef50_Q298C7 Cluster: GA18650-PA; n=1; Drosophila
pseudoobscura|Rep: GA18650-PA - Drosophila pseudoobscura
(Fruit fly)
Length = 381
Score = 48.4 bits (110), Expect = 1e-04
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 2/123 (1%)
Frame = +1
Query: 85 TQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
TQN+D L AG ++LIE HG+ + C CK+ + + K +
Sbjct: 165 TQNIDTLDRLAGIPDEKLIEAHGSFHTNHCIGCKK-----EYDMAWMK----------KE 209
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
I LP C C +++P IV+FGE+L + + CD+ +++GT+ V+P A
Sbjct: 210 IFSDRLPTCTS--CKKIVKPDIVFFGENLPEKFHNSLDGDFKECDLLIIMGTTLEVHPFA 267
Query: 439 MFA 447
A
Sbjct: 268 SLA 270
>UniRef50_Q8N6T7-2 Cluster: Isoform 2 of Q8N6T7 ; n=5;
Catarrhini|Rep: Isoform 2 of Q8N6T7 - Homo sapiens
(Human)
Length = 328
Score = 47.6 bits (108), Expect = 2e-04
Identities = 21/42 (50%), Positives = 28/42 (66%), Gaps = 2/42 (4%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKR--LIELHGNLYKTRCTKCKEVLVNN 198
+++QNVDGLH R+G R L ELHGN++ C KCK V +
Sbjct: 110 LVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRD 151
>UniRef50_Q7ZVK3 Cluster: NAD-dependent deacetylase sirtuin-2; n=12;
Coelomata|Rep: NAD-dependent deacetylase sirtuin-2 -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 379
Score = 47.2 bits (107), Expect = 3e-04
Identities = 37/129 (28%), Positives = 60/129 (46%), Gaps = 2/129 (1%)
Frame = +1
Query: 85 TQNVDGLHARAGTKR--LIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
+QN+D L AG + LIE HG + + C L + + K +
Sbjct: 164 SQNIDTLERVAGLEGEDLIEAHGTFHTSHCVS---FLCRKEYSMDWMKNQ---------- 210
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
I + +P C CG+L++P IV+FGESL + + CD+ +++GTS V P A
Sbjct: 211 IFSEEIPKCDS--CGSLVKPDIVFFGESLPSRFFTSMKADFPQCDLLIIMGTSLQVQPFA 268
Query: 439 MFAPQAASR 465
+ ++R
Sbjct: 269 SLVSRVSNR 277
>UniRef50_O25849 Cluster: NAD-dependent deacetylase; n=11;
Bacteria|Rep: NAD-dependent deacetylase - Helicobacter
pylori (Campylobacter pylori)
Length = 229
Score = 47.2 bits (107), Expect = 3e-04
Identities = 22/50 (44%), Positives = 32/50 (64%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTK 174
H A+A+ E ++ ++ +ITQNVD LH RAG+ R++ LHG L R K
Sbjct: 69 HKALAELEKHY----QVNIITQNVDDLHERAGSSRILHLHGELLSVRSEK 114
Score = 40.3 bits (90), Expect = 0.037
Identities = 24/67 (35%), Positives = 38/67 (56%)
Frame = +1
Query: 310 LRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFN 489
LRP IVWFGE++ +L+ A + + +++GTS VYPAA A + A++ +
Sbjct: 138 LRPDIVWFGEAV--PLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTH-AHKDALI--YY 192
Query: 490 IEPTPAN 510
I+P N
Sbjct: 193 IDPKAKN 199
>UniRef50_UPI000023DCB3 Cluster: hypothetical protein FG05505.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG05505.1 - Gibberella zeae PH-1
Length = 330
Score = 46.8 bits (106), Expect = 4e-04
Identities = 23/58 (39%), Positives = 33/58 (56%)
Frame = +1
Query: 307 LLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVA 480
+L+P +V FGES++ + AAE A+ +VVGTS Y A A +A RG +A
Sbjct: 199 ILKPAVVMFGESIDSHVKNAAEEAIDNAGKLVVVGTSLATYSAWRLAKRAQDRGMPIA 256
>UniRef50_Q1RL71 Cluster: Zinc finger protein; n=2; Ciona
intestinalis|Rep: Zinc finger protein - Ciona
intestinalis (Transparent sea squirt)
Length = 523
Score = 46.4 bits (105), Expect = 6e-04
Identities = 40/131 (30%), Positives = 56/131 (42%), Gaps = 3/131 (2%)
Frame = +1
Query: 73 ITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*Y 246
+ + TQN+DGL AG +L+E HG CTKC + CK +
Sbjct: 206 LRMYTQNIDGLERLAGIPPSKLVEAHGTFSTASCTKCGK----------KCKGEVIK--- 252
Query: 247 GGFDIPVKLLPHCKKAH-CGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSV 423
I ++P C+ C ++P IV+FGE L + +CD+ LV GTS
Sbjct: 253 --DKILKGVIPRCQLTPLCYGTIKPDIVFFGEDLPKRFYYYLKD-FPSCDLLLVFGTSLQ 309
Query: 424 VYPAAMFAPQA 456
V P A A
Sbjct: 310 VEPFASLVDSA 320
>UniRef50_A7RLD5 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 335
Score = 46.4 bits (105), Expect = 6e-04
Identities = 38/124 (30%), Positives = 54/124 (43%), Gaps = 2/124 (1%)
Frame = +1
Query: 73 ITVITQNVDGLHARAG--TKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*Y 246
+ + TQN+DGL AG ++L+E HG C C + D R
Sbjct: 81 LRMYTQNIDGLERLAGLPAEKLVEAHGTFSTASCISCHH---SYDG-------EQIRKTI 130
Query: 247 GGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVV 426
DIP C+ C +++P +V+FGE L + E CD+ LV+GTS V
Sbjct: 131 ENGDIP-----RCETIKCKGVIKPDVVFFGEDLPKRFY-SFEIDFRKCDLLLVMGTSLEV 184
Query: 427 YPAA 438
P A
Sbjct: 185 EPFA 188
>UniRef50_Q9NTG7 Cluster: NAD-dependent deacetylase sirtuin-3,
mitochondrial precursor; n=22; Euteleostomi|Rep:
NAD-dependent deacetylase sirtuin-3, mitochondrial
precursor - Homo sapiens (Human)
Length = 399
Score = 46.4 bits (105), Expect = 6e-04
Identities = 37/131 (28%), Positives = 57/131 (43%), Gaps = 3/131 (2%)
Frame = +1
Query: 55 HGSQKKITVITQNVDGLHARAG--TKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*R 228
H + + TQN+DGL +G +L+E HG CT C+ D
Sbjct: 217 HDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRA------ 270
Query: 229 SPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESL-EHDILEAAEHAMSTCDVCLV 405
D+ +P C C +++P IV+FGE L + +L + M+ D+ L+
Sbjct: 271 ---------DVMADRVPRCPV--CTGVVKPDIVFFGEPLPQRFLLHVVDFPMA--DLLLI 317
Query: 406 VGTSSVVYPAA 438
+GTS V P A
Sbjct: 318 LGTSLEVEPFA 328
>UniRef50_A0JXS0 Cluster: Silent information regulator protein Sir2
precursor; n=11; Actinomycetales|Rep: Silent information
regulator protein Sir2 precursor - Arthrobacter sp.
(strain FB24)
Length = 306
Score = 46.0 bits (104), Expect = 7e-04
Identities = 47/179 (26%), Positives = 71/179 (39%), Gaps = 17/179 (9%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE 183
+A+ GH A A+ E +ITQNVD LH AG+ +++LHG + C C
Sbjct: 100 RADPNDGHAAAARLEQRG---LLTGLITQNVDRLHEDAGSVNVVDLHGRFDRVACLSCAR 156
Query: 184 VLVNNDSPICTCK*RSPRF*YGGF-DIPVKLLPHCKK-------------AHC---GALL 312
+ + +P F D V++ P AHC G L
Sbjct: 157 -RYSRTLLAGVLEELNPGFLEQALADGVVEMAPDADATVEDSALIRSFVVAHCPACGGTL 215
Query: 313 RPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFN 489
+P V+FGE++ D +E + + +V G+S V F AA + V N
Sbjct: 216 KPDFVYFGENVPKDRVERSYAMVDEAGALVVAGSSLTVMSGLRFVRHAAKQEKPVVIIN 274
>UniRef50_Q55DB0 Cluster: NAD(+)-dependent deacetylase, silent
information regulator protein (Sir2) family protein;
n=1; Dictyostelium discoideum AX4|Rep: NAD(+)-dependent
deacetylase, silent information regulator protein (Sir2)
family protein - Dictyostelium discoideum AX4
Length = 346
Score = 46.0 bits (104), Expect = 7e-04
Identities = 50/168 (29%), Positives = 73/168 (43%), Gaps = 10/168 (5%)
Frame = +1
Query: 19 AGHFAIAKFEDNHGSQKKITVITQNVDGLH--ARAGTKRLIELHG--NLYKTRCTKCK-- 180
+GH AI+ F + GS VITQNVD LH A+ ++L+E+HG +LYK C+
Sbjct: 113 SGHLAISNFVEYLGSN----VITQNVDALHLKAKVPIEKLVEVHGRISLYKCITKGCRFE 168
Query: 181 -EVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESL-EHD 354
+ ++N I G +I L P CKK + P + F E+ H
Sbjct: 169 YDDTIDN-IEIGDYSINGTTMKQGNLEITPPLCPECKKP-----ILPQSLLFDENYSSHQ 222
Query: 355 I--LEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNI 492
+E A + D+ + +GTS V A S + FNI
Sbjct: 223 FYNIEKAMDWIQEADIFIFIGTSFSVGITEEVICHAQSERKKMFNFNI 270
>UniRef50_Q0R0H8 Cluster: Sir2-like protein; n=1; Naegleria sp.
TES-2005|Rep: Sir2-like protein - Naegleria sp. TES-2005
Length = 137
Score = 46.0 bits (104), Expect = 7e-04
Identities = 26/73 (35%), Positives = 35/73 (47%)
Frame = +1
Query: 286 KKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASR 465
+K CG LR I+ FGE+L + L A D LV+GTS +V PAA
Sbjct: 25 RKCECGGDLRDTIIHFGENLPINELNIAYKNSQMGDFALVMGTSLMVNPAAALPGMVLEN 84
Query: 466 GAIVAEFNIEPTP 504
G + N++ TP
Sbjct: 85 GGSMCIVNLQKTP 97
>UniRef50_A4VDQ9 Cluster: Chromatin regulatory protein sir2; n=1;
Tetrahymena thermophila SB210|Rep: Chromatin regulatory
protein sir2 - Tetrahymena thermophila SB210
Length = 279
Score = 46.0 bits (104), Expect = 7e-04
Identities = 40/122 (32%), Positives = 58/122 (47%), Gaps = 3/122 (2%)
Frame = +1
Query: 82 ITQNVDGLHARAG--TKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGF 255
ITQN+DGL +AG K LI+ HGNL K+ C +C + + I F G
Sbjct: 120 ITQNIDGLELKAGLDKKYLIQAHGNLEKSHCIEC-----HKEDTI-------EYFKEGVL 167
Query: 256 DIPVKLLPHCKKA-HCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYP 432
+ +C+K +C L+P + +FGE L + M D+ +V+GTS V P
Sbjct: 168 KSDDAV--NCRKTKNCQGKLKPSVTFFGEKLPFYFYKIPLQ-MRFADLIIVMGTSLKVQP 224
Query: 433 AA 438
A
Sbjct: 225 FA 226
>UniRef50_A2QFF9 Cluster: Complex: Sir2p is one of four Silent
Information Regulator genes in yeast. Sir2p; n=6;
Pezizomycotina|Rep: Complex: Sir2p is one of four Silent
Information Regulator genes in yeast. Sir2p -
Aspergillus niger
Length = 378
Score = 46.0 bits (104), Expect = 7e-04
Identities = 40/139 (28%), Positives = 60/139 (43%), Gaps = 2/139 (1%)
Frame = +1
Query: 85 TQNVDGLHARAGTK--RLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
+QN+D L AG +++E HG+ C CK + K +
Sbjct: 125 SQNIDCLERLAGVPGDKIVEAHGSFATQHCIDCKAEYPEDLMKKAITKGK---------- 174
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
+P+C + C L++P IV+FGESL D + + D+C+V+GTS V P A
Sbjct: 175 -----VPYCTQ--CKGLVKPDIVFFGESLPADFFDNRD-LPEQADLCIVMGTSLQVQPFA 226
Query: 439 MFAPQAASRGAIVAEFNIE 495
P S G N+E
Sbjct: 227 SL-PAFVSDGVPRVLINME 244
>UniRef50_Q4P3S4 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 400
Score = 45.6 bits (103), Expect = 0.001
Identities = 21/72 (29%), Positives = 37/72 (51%)
Frame = +1
Query: 295 HCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAI 474
+CG +L+P +++FGES+ + + + + + L++GTS Y A QA +
Sbjct: 273 NCGGVLKPAVIFFGESVPDKLRDHSYEMVENANAMLLIGTSLATYSAFRLVKQAVEQNKP 332
Query: 475 VAEFNIEPTPAN 510
V N PT A+
Sbjct: 333 VMVLNRGPTRAD 344
>UniRef50_Q4UH74 Cluster: Sir2-like histone deacetylase, putative;
n=2; Theileria|Rep: Sir2-like histone deacetylase,
putative - Theileria annulata
Length = 928
Score = 45.2 bits (102), Expect = 0.001
Identities = 28/57 (49%), Positives = 35/57 (61%), Gaps = 4/57 (7%)
Frame = +1
Query: 64 QKKIT-VITQNVDGLHARAGT--KRLIELHGNLYKTRCTKC-KEVLVNNDSPICTCK 222
+KKI +ITQNVDGLHA +G +L ELHGN++ RC C K N SP + K
Sbjct: 202 RKKIRYIITQNVDGLHAVSGIPFDKLSELHGNVFVQRCLFCHKRYQRNYVSPTISFK 258
>UniRef50_Q7VIN2 Cluster: NAD-dependent deacetylase; n=1;
Helicobacter hepaticus|Rep: NAD-dependent deacetylase -
Helicobacter hepaticus
Length = 255
Score = 45.2 bits (102), Expect = 0.001
Identities = 49/162 (30%), Positives = 70/162 (43%), Gaps = 5/162 (3%)
Frame = +1
Query: 55 HGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSP 234
H ++ ITQNVD L RAG +I LHG L K C +C+ +
Sbjct: 92 HKDPIEVIHITQNVDDLLERAGVSNVIHLHGELCKIICPQCEHI---------------- 135
Query: 235 RF*YGGFDIP-VKLLPH-CKKAHCGALLRPHIVWFGE-SLEHDILEAAEHAMSTCDVCLV 405
FDI PH C G L+P IV+F E + ++ I+ +S+ D LV
Sbjct: 136 ------FDIGYTHFEPHNCPNCDYGK-LKPFIVFFYERAPKYVIMHDIFSQLSSKDCVLV 188
Query: 406 VGTSSVVYPAAMFAPQAASRGAIVAEF--NIEPTPANLISIF 525
+GTS V + A SR I + N++ P+ S+F
Sbjct: 189 IGTSGNVVDISTILAFAESRARIGYKILNNLQYCPSIAESVF 230
>UniRef50_UPI000050FCF4 Cluster: COG0846: NAD-dependent protein
deacetylases, SIR2 family; n=1; Brevibacterium linens
BL2|Rep: COG0846: NAD-dependent protein deacetylases,
SIR2 family - Brevibacterium linens BL2
Length = 309
Score = 44.8 bits (101), Expect = 0.002
Identities = 45/161 (27%), Positives = 68/161 (42%), Gaps = 20/161 (12%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKR-----LIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF* 243
++TQNVDGLH A + +I+LHG+L + C K + + + D +P F
Sbjct: 115 IVTQNVDGLHQAAAREEGSRSPVIDLHGSLDRVICLK-EGHMFDRDWVQIQLSELNPEFA 173
Query: 244 -YGGFD-IPVKLLPH-------------CKKAHCGALLRPHIVWFGESLEHDILEAAEHA 378
G D I V+ P CG +L+P +V+FG+S+ L+ A
Sbjct: 174 KLVGIDPIDVETAPDGDVDLEETADFIVTDCPRCGGILKPDVVYFGDSVPPARLQEANRI 233
Query: 379 MSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPT 501
+ +V+G+S V F AA G V PT
Sbjct: 234 CAEASGIVVLGSSLAVLSGLRFVRAAAKAGKPVVIVTDGPT 274
>UniRef50_A4QX96 Cluster: Putative uncharacterized protein; n=2;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 534
Score = 44.8 bits (101), Expect = 0.002
Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 2/100 (2%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKR--LIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGG 252
+ TQN+DGL AG ++E HG+ RC C + + P +
Sbjct: 123 LFTQNIDGLEKAAGVPPDLVVEAHGSFDSQRCIDCAQ-----EFPAADMR---------- 167
Query: 253 FDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAE 372
+ +PHC K CG L++P IV+FGE L A E
Sbjct: 168 AHVATSSVPHCGK--CGGLVKPDIVFFGEQLPDRFFRARE 205
>UniRef50_Q9VAQ1 Cluster: CG11305-PA; n=8; Coelomata|Rep: CG11305-PA
- Drosophila melanogaster (Fruit fly)
Length = 771
Score = 44.4 bits (100), Expect = 0.002
Identities = 54/194 (27%), Positives = 79/194 (40%), Gaps = 13/194 (6%)
Frame = +1
Query: 1 AKANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKR--LIELHGNLYKTRCTK 174
+ AN T H A+ + H + V++QN DGLH R+G R L E+HGN+Y C
Sbjct: 165 SSANPTYTHMALYEL---HRRRLLHHVVSQNCDGLHLRSGLPRNSLSEIHGNMYVEVCKN 221
Query: 175 CKEVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAH-----CGALLRPHIVWFGE 339
C+ V + FD +C K H C L IV FGE
Sbjct: 222 CRPNSVY----------------WRQFDTTEMTARYCHKTHRLCHRCSEPLYDTIVHFGE 265
Query: 340 --SLEHDILEAAEHA-MSTCDVCLVVGTSSVV---YPAAMFAPQAASRGAIVAEFNIEPT 501
+++ + A A DV L +G+S V Y + A + A + N++ T
Sbjct: 266 RGNVKWPLNWAGATANAQRADVILCLGSSLKVLKKYTWLWQMDRPARQRAKICVVNLQWT 325
Query: 502 PANLISIFYFEGPC 543
P + I+ G C
Sbjct: 326 PKDAIASIKINGKC 339
>UniRef50_A2GAR7 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 312
Score = 44.4 bits (100), Expect = 0.002
Identities = 38/140 (27%), Positives = 61/140 (43%), Gaps = 2/140 (1%)
Frame = +1
Query: 85 TQNVDGLHARAGTK--RLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
TQN+D L AG +++E HG+ C KC D F G
Sbjct: 123 TQNIDSLDISAGLPLDKIVEAHGSFTYLTCRKCGSKFEFADY--------KEEFQTG--- 171
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
K++ HC++ G +++P +V++GE L +E+ ST ++ +++GTS V P
Sbjct: 172 ---KVV-HCRECKEG-VIKPDVVFYGEDLPQRFHHLSENDFSTANLLIIMGTSLTVSPCC 226
Query: 439 MFAPQAASRGAIVAEFNIEP 498
M P + N EP
Sbjct: 227 ML-PGYCPPNCVRVLINNEP 245
>UniRef50_Q6C219 Cluster: Yarrowia lipolytica chromosome F of strain
CLIB122 of Yarrowia lipolytica; n=1; Yarrowia
lipolytica|Rep: Yarrowia lipolytica chromosome F of
strain CLIB122 of Yarrowia lipolytica - Yarrowia
lipolytica (Candida lipolytica)
Length = 320
Score = 44.4 bits (100), Expect = 0.002
Identities = 38/137 (27%), Positives = 62/137 (45%), Gaps = 8/137 (5%)
Frame = +1
Query: 67 KKITVITQNVDGLHARAGTK--RLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF 240
K + + TQN+D L AG + ++++ HG + C +C + TC+ P
Sbjct: 146 KLLRIYTQNIDDLEHIAGIEESKMVQCHGAFHMATCRQCGAKV--------TCESLRP-- 195
Query: 241 *YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESL----EHDILEAAEHAMST--CDVCL 402
+I +P C++ C +++P IV+FGE+L H + T D+ L
Sbjct: 196 -----EIVAGEIPMCRRKRCEGVIKPDIVFFGEALPDRFRHMVRSDIIMGGPTPKVDLFL 250
Query: 403 VVGTSSVVYPAAMFAPQ 453
+GTS V PA A Q
Sbjct: 251 CLGTSLKVSPACDIAKQ 267
>UniRef50_A3LN35 Cluster: NAD-dependent histone deacetylase SIR2;
n=1; Pichia stipitis|Rep: NAD-dependent histone
deacetylase SIR2 - Pichia stipitis (Yeast)
Length = 391
Score = 44.4 bits (100), Expect = 0.002
Identities = 34/120 (28%), Positives = 49/120 (40%), Gaps = 2/120 (1%)
Frame = +1
Query: 85 TQNVDGLHARAGTK--RLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
TQN+D L +R G +LI+ HG+ C C + PR
Sbjct: 199 TQNIDNLESRVGIHPDKLIQCHGSFGSASCLTCSNRFAGHKIFEHIRHQHVPRCSTCWKT 258
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
I ++ H +++P I +FGE L E TCD+ +VVGTS V P +
Sbjct: 259 IQEAVIIH-------GVIKPDITFFGEDLPKKFYRLLEPDCQTCDLVIVVGTSLKVEPVS 311
>UniRef50_Q7QZ37 Cluster: GLP_464_19573_21615; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_464_19573_21615 - Giardia lamblia
ATCC 50803
Length = 680
Score = 44.0 bits (99), Expect = 0.003
Identities = 39/124 (31%), Positives = 58/124 (46%), Gaps = 6/124 (4%)
Frame = +1
Query: 79 VITQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVL-VNNDSPICTCK*RSPR-F*Y 246
+ TQN+D L AG +R+++ HG+ CK + + N S +CT + F
Sbjct: 110 IYTQNIDELEIFAGVSPRRILQCHGSY-------CKGLYCLGNVSGVCTYQVEDQNVFRA 162
Query: 247 GGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAE--HAMSTCDVCLVVGTSS 420
D V HC + CG +L+P IV+FGE L + A E + L++GTS
Sbjct: 163 AAMDQSVS---HCPR--CGRVLKPRIVFFGEQLPSEFQLAPEIIGDAEKTSMLLILGTSL 217
Query: 421 VVYP 432
V P
Sbjct: 218 TVAP 221
>UniRef50_Q7SB01 Cluster: Putative uncharacterized protein
NCU07624.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU07624.1 - Neurospora crassa
Length = 437
Score = 44.0 bits (99), Expect = 0.003
Identities = 44/154 (28%), Positives = 60/154 (38%), Gaps = 2/154 (1%)
Frame = +1
Query: 16 TAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTK--RLIELHGNLYKTRCTKCKEVL 189
T H A+ + ++ G K + I+QN DGLH R+G + + ELHGN C C +
Sbjct: 83 TKTHMALVELQER-GILKGL--ISQNCDGLHRRSGIRADMISELHGNTNIEHCKNCGKEF 139
Query: 190 VNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAA 369
+ D R G P+ L L I+ F E L A
Sbjct: 140 LRADFYAVAPDNRPLHDHRTGRKCPICLTQP---------LHDTIIHFSEDLPLGPWSRA 190
Query: 370 EHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGA 471
E D+CLV+G+S V PA R A
Sbjct: 191 EAHCEKADLCLVLGSSLTVTPANELPQLVGERAA 224
>UniRef50_Q4P1X1 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 434
Score = 44.0 bits (99), Expect = 0.003
Identities = 40/127 (31%), Positives = 55/127 (43%), Gaps = 2/127 (1%)
Frame = +1
Query: 64 QKKITVITQNVDGLHARAGTK--RLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPR 237
QK V TQNVD L AG + +++E HG+ + C CK + D K S +
Sbjct: 133 QKLKRVFTQNVDTLERIAGVEADKVVEAHGSFATSTCIVCKHSV---DDDWIRNKVESGQ 189
Query: 238 F*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTS 417
K G L++P IV+FGESL + T D+ +V+GTS
Sbjct: 190 VARCPRPKCPGRKTGSKGEQRGGLVKPDIVFFGESLPPRFFRCIPD-LKTADLLIVMGTS 248
Query: 418 SVVYPAA 438
V P A
Sbjct: 249 LQVQPFA 255
>UniRef50_Q07FY7 Cluster: Sirtuin (Silent mating type information
regulation 2 homolog) 3; n=3; Xenopus|Rep: Sirtuin
(Silent mating type information regulation 2 homolog) 3
- Xenopus tropicalis (Western clawed frog) (Silurana
tropicalis)
Length = 401
Score = 43.6 bits (98), Expect = 0.004
Identities = 33/120 (27%), Positives = 54/120 (45%), Gaps = 2/120 (1%)
Frame = +1
Query: 85 TQNVDGLHARAG--TKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
TQN+DGL AG ++++E+HG + C+ C N+ + + G
Sbjct: 216 TQNIDGLERLAGIPVEKIVEVHGTFFSASCSLCYTPFPANE---------AKELIFDGNP 266
Query: 259 IPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
P CK C ++P IV+FGE L +A + D+ +++GTS + P A
Sbjct: 267 ------PCCK--FCAGPVKPDIVFFGEDLPQTFTQAYQD-FPKADLLIIMGTSLKIEPFA 317
>UniRef50_Q1RPU3 Cluster: Zinc finger protein; n=1; Ciona
intestinalis|Rep: Zinc finger protein - Ciona
intestinalis (Transparent sea squirt)
Length = 737
Score = 43.6 bits (98), Expect = 0.004
Identities = 31/121 (25%), Positives = 53/121 (43%), Gaps = 2/121 (1%)
Frame = +1
Query: 85 TQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFDIP 264
TQN+D L AG ++++ HG+ C C + N + DI
Sbjct: 279 TQNIDTLEQVAGISKVVQCHGSFATASCCSC-DYKTNCEELRA--------------DIF 323
Query: 265 VKLLPHCKKAHCG--ALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
+++PHC + +++P IV+FGE+L D+ +V+G+S V P A
Sbjct: 324 NQVVPHCPRCPSDDPGVIKPDIVFFGENLPQQFHRQMTSDKDDADLLIVIGSSLKVRPVA 383
Query: 439 M 441
+
Sbjct: 384 L 384
>UniRef50_A5DNV7 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 403
Score = 43.6 bits (98), Expect = 0.004
Identities = 37/132 (28%), Positives = 52/132 (39%), Gaps = 2/132 (1%)
Frame = +1
Query: 67 KKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF 240
K + V TQN+D L AG R++ HG L + C C+ + + K R +
Sbjct: 199 KLLRVYTQNIDNLELAAGIDPSRIVHCHGTLSTSTCLTCRATF-SGAATFAAIKMRQVPY 257
Query: 241 *YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSS 420
+ V L L++P I +FGE L + CD+ LV GTS
Sbjct: 258 ----CSLCVTDLGSVPMK---GLIKPDITFFGEDLSSRFETMIGKDVEECDLLLVAGTSL 310
Query: 421 VVYPAAMFAPQA 456
V P A A
Sbjct: 311 KVEPVASIVRNA 322
>UniRef50_UPI0000D573CE Cluster: PREDICTED: similar to CG11305-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG11305-PA - Tribolium castaneum
Length = 627
Score = 43.2 bits (97), Expect = 0.005
Identities = 20/36 (55%), Positives = 24/36 (66%), Gaps = 2/36 (5%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKR--LIELHGNLYKTRCTKCK 180
V++QN DGLH R+G R L ELHGN+Y C CK
Sbjct: 184 VVSQNCDGLHLRSGLPRTALSELHGNMYIEVCKTCK 219
>UniRef50_A6DES9 Cluster: Transcriptional regulator, Sir2 family
protein; n=2; Epsilonproteobacteria|Rep: Transcriptional
regulator, Sir2 family protein - Caminibacter
mediatlanticus TB-2
Length = 264
Score = 43.2 bits (97), Expect = 0.005
Identities = 29/90 (32%), Positives = 48/90 (53%), Gaps = 3/90 (3%)
Frame = +1
Query: 79 VITQNVDGLHARAGTK--RLIELHGNLYKTRCTK-CKEVLVNNDSPICTCK*RSPRF*YG 249
V T NVDG +AG +++E+HG+++ +CTK CK+ + N+ I + +F
Sbjct: 102 VFTSNVDGQFQKAGFSEMKIVEIHGSIHYLQCTKPCKQEIWENNEEI---EVDMDKF--- 155
Query: 250 GFDIPVKLLPHCKKAHCGALLRPHIVWFGE 339
K P+CK C + RP+I+ FG+
Sbjct: 156 ----EAKNFPYCK--FCKKIARPNILMFGD 179
>UniRef50_Q175I4 Cluster: Chromatin regulatory protein sir2; n=3;
Coelomata|Rep: Chromatin regulatory protein sir2 - Aedes
aegypti (Yellowfever mosquito)
Length = 720
Score = 43.2 bits (97), Expect = 0.005
Identities = 25/60 (41%), Positives = 34/60 (56%), Gaps = 2/60 (3%)
Frame = +1
Query: 7 ANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKR--LIELHGNLYKTRCTKCK 180
A+ T H A+++ G K V++QN DGLH R+G R L E+HGN+Y C CK
Sbjct: 124 ADPTYTHMALSELH-RRGILKH--VVSQNCDGLHLRSGLPRFCLSEVHGNMYVEVCKNCK 180
>UniRef50_A7SX90 Cluster: Predicted protein; n=3; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 306
Score = 43.2 bits (97), Expect = 0.005
Identities = 35/123 (28%), Positives = 55/123 (44%), Gaps = 4/123 (3%)
Frame = +1
Query: 85 TQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFDIP 264
+QN+D L AG R+I+ HG+ C +CK + P K DI
Sbjct: 160 SQNIDTLEQVAGITRVIQCHGSFSTASCMRCKHKV-----PCEAIK----------EDIF 204
Query: 265 VKLLPHCKKA----HCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYP 432
K +P C ++++P IV+FGESL + + D+ +V+G+S V P
Sbjct: 205 RKNIPVCSTCSPDEEFPSIMKPDIVFFGESLPSNFYTHLGDDSNKADLLIVIGSSLKVRP 264
Query: 433 AAM 441
A+
Sbjct: 265 VAL 267
>UniRef50_A5K3P4 Cluster: Putative uncharacterized protein; n=1;
Plasmodium vivax|Rep: Putative uncharacterized protein -
Plasmodium vivax
Length = 1259
Score = 43.2 bits (97), Expect = 0.005
Identities = 18/35 (51%), Positives = 25/35 (71%), Gaps = 2/35 (5%)
Frame = +1
Query: 79 VITQNVDGLHARAGTK--RLIELHGNLYKTRCTKC 177
+ITQN+D LH R GTK ++ E+HGN++ RC C
Sbjct: 362 LITQNIDSLHYRCGTKFSKISEIHGNIFIERCDFC 396
>UniRef50_Q7RP35 Cluster: Sir2-like protein; n=5; Plasmodium
(Vinckeia)|Rep: Sir2-like protein - Plasmodium yoelii
yoelii
Length = 1159
Score = 42.7 bits (96), Expect = 0.007
Identities = 18/35 (51%), Positives = 25/35 (71%), Gaps = 2/35 (5%)
Frame = +1
Query: 79 VITQNVDGLHARAGTK--RLIELHGNLYKTRCTKC 177
+ITQN+D LH R GTK ++ E+HGN++ RC C
Sbjct: 256 LITQNIDSLHYRCGTKFSQISEIHGNIFIERCDFC 290
>UniRef50_Q4QB33 Cluster: Sir2-family protein-like protein; n=4;
Trypanosomatidae|Rep: Sir2-family protein-like protein -
Leishmania major
Length = 320
Score = 42.7 bits (96), Expect = 0.007
Identities = 26/75 (34%), Positives = 37/75 (49%), Gaps = 1/75 (1%)
Frame = +1
Query: 298 CGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLV-VGTSSVVYPAAMFAPQAASRGAI 474
C +PH+V FGE++ I+EA + CL+ +GTS VY A + QA G
Sbjct: 210 CNGFFKPHVVLFGENVPKPIVEATMSLVRDKASCLLCLGTSLQVYSAYRYVLQANQLGIP 269
Query: 475 VAEFNIEPTPANLIS 519
VA N T + I+
Sbjct: 270 VAIVNAGTTRGDAIA 284
>UniRef50_Q6C8V5 Cluster: Similar to tr|Q9FY91 Arabidopsis thaliana
SIR2-family protein; n=1; Yarrowia lipolytica|Rep:
Similar to tr|Q9FY91 Arabidopsis thaliana SIR2-family
protein - Yarrowia lipolytica (Candida lipolytica)
Length = 411
Score = 42.7 bits (96), Expect = 0.007
Identities = 25/72 (34%), Positives = 36/72 (50%)
Frame = +1
Query: 274 LPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQ 453
+P C +CG +L+P IV+FGES+ A + + D LV+GTS + A Q
Sbjct: 312 IPPC--LNCGGVLKPSIVFFGESVPEADRARARDLLESSDQLLVIGTSLSTFSAFDLVRQ 369
Query: 454 AASRGAIVAEFN 489
+G VA N
Sbjct: 370 FYKQGKKVAVLN 381
>UniRef50_Q6BPH5 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Saccharomycetaceae|Rep: Debaryomyces hansenii chromosome
E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 573
Score = 42.7 bits (96), Expect = 0.007
Identities = 44/150 (29%), Positives = 64/150 (42%), Gaps = 7/150 (4%)
Frame = +1
Query: 10 NYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTK--RLIELHGNLYKTRCTKCK- 180
+YT H A K N G K + TQN+D L + G K +LI+ HG+ C CK
Sbjct: 327 SYTPLH-AFIKLLQNKG--KLLRNYTQNIDNLESNVGIKPEKLIQCHGSFATASCVTCKY 383
Query: 181 EVLVNNDSPICTCK*RSPRF*Y-GGFDIPVKLLPHCKKAHCG---ALLRPHIVWFGESLE 348
+V P K R Y K+L + + A+ +++P I +FGE L
Sbjct: 384 QVKGEKIYP----KIREKEVPYCPKCKNARKILLNKEDAYVPESYGVMKPDITFFGEPLP 439
Query: 349 HDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
+ CD+ + +GTS V P A
Sbjct: 440 TRFHNMIRQDLMECDLLISIGTSLKVSPVA 469
>UniRef50_UPI00015B56BB Cluster: PREDICTED: similar to
ENSANGP00000025716; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000025716 - Nasonia
vitripennis
Length = 581
Score = 41.9 bits (94), Expect = 0.012
Identities = 18/36 (50%), Positives = 24/36 (66%), Gaps = 2/36 (5%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKR--LIELHGNLYKTRCTKCK 180
+++QN DGLH R+G R L E+HGN+Y C CK
Sbjct: 175 IVSQNCDGLHLRSGIPRPLLSEVHGNMYVEVCRTCK 210
>UniRef50_A6Q2C0 Cluster: Transcriptional regulator, Sir2 family;
n=2; Bacteria|Rep: Transcriptional regulator, Sir2
family - Nitratiruptor sp. (strain SB155-2)
Length = 268
Score = 41.5 bits (93), Expect = 0.016
Identities = 29/95 (30%), Positives = 53/95 (55%), Gaps = 3/95 (3%)
Frame = +1
Query: 64 QKKITVITQNVDGLHARAG--TKRLIELHGNLYKTRCTK-CKEVLVNNDSPICTCK*RSP 234
+K+ V+T NVDG +AG ++ E+HG+++ +C K C++ + + D + +
Sbjct: 98 KKEYFVVTSNVDGQFQKAGFDEMKIDEVHGSIHYLQCIKPCRDDIWSADG--VDIQIDTE 155
Query: 235 RF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGE 339
RF + + LP C +CGA+ RP+I+ FG+
Sbjct: 156 RF------LAREPLPKCP--YCGAVARPNILMFGD 182
>UniRef50_A0C2R2 Cluster: Chromosome undetermined scaffold_145,
whole genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_145,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 258
Score = 41.5 bits (93), Expect = 0.016
Identities = 34/122 (27%), Positives = 55/122 (45%), Gaps = 2/122 (1%)
Frame = +1
Query: 73 ITVITQNVDGLHARAGTK--RLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*Y 246
+ TQN+DGL AG + ++I++HG+ C CK+ C + Y
Sbjct: 105 LNCFTQNIDGLELVAGVRESKVIQVHGHRRTASCIDCKKT-------YCV------KTFY 151
Query: 247 GGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVV 426
D + K C L++P +V+FG+SL E +S D+ +++GTS V
Sbjct: 152 QNVDKSEIM----KCTDCNGLIKPDVVFFGQSLPQLYFEKLPE-ISLSDLVIIMGTSLQV 206
Query: 427 YP 432
P
Sbjct: 207 QP 208
>UniRef50_Q4WET3 Cluster: SIR2 family histone deacetylase, putative;
n=4; Pezizomycotina|Rep: SIR2 family histone
deacetylase, putative - Aspergillus fumigatus (Sartorya
fumigata)
Length = 381
Score = 41.5 bits (93), Expect = 0.016
Identities = 20/62 (32%), Positives = 34/62 (54%)
Frame = +1
Query: 307 LLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEF 486
+L+P +V FGE+++ + AAE A+ L++G+S Y A +A RG +A
Sbjct: 276 ILKPAVVMFGENIDPGVKTAAEEAIDDAGRLLILGSSLATYSAWRLVERAHRRGMPIAII 335
Query: 487 NI 492
N+
Sbjct: 336 NL 337
Score = 36.3 bits (80), Expect = 0.60
Identities = 17/36 (47%), Positives = 23/36 (63%), Gaps = 1/36 (2%)
Frame = +1
Query: 76 TVITQNVDGLHARAGTKR-LIELHGNLYKTRCTKCK 180
+V+TQNVD H+ A + IELHG+L CT C+
Sbjct: 139 SVVTQNVDSFHSIAHPELPTIELHGHLKSVVCTSCR 174
>UniRef50_A5DJ74 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 522
Score = 41.5 bits (93), Expect = 0.016
Identities = 32/124 (25%), Positives = 52/124 (41%), Gaps = 6/124 (4%)
Frame = +1
Query: 85 TQNVDGLHARAG--TKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGGFD 258
TQN+D L + G + R+++ HG+ C CK + ++ C R+ Y
Sbjct: 298 TQNIDNLESNVGINSDRVVQCHGSFATATCVTCKNTIPGHEIFECI---RNKEVAYCTKC 354
Query: 259 IPVKLLPHCKK----AHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVV 426
+L K +++P I +FGE L + + CD+ + VGTS V
Sbjct: 355 TNSRLALMDKDDAYVPESYGVMKPDITFFGELLPAKFHDTINEDLHECDLVISVGTSLKV 414
Query: 427 YPAA 438
P A
Sbjct: 415 APVA 418
>UniRef50_A4R235 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 315
Score = 41.5 bits (93), Expect = 0.016
Identities = 33/98 (33%), Positives = 51/98 (52%), Gaps = 4/98 (4%)
Frame = +1
Query: 256 DIPVKLLPHCKKAHCGA-LLRPHIVWFGESL-EHDILEAAEHAMSTCDVCLVVGTSSVVY 429
D+ PHC A CG L+RP + ++L + D A + A+ DV LVVGT++V+
Sbjct: 208 DLEPSRFPHC--AACGKHLVRPTVQPNRQALADVDDFVARKPAV---DVALVVGTAAVLP 262
Query: 430 PAAMFAPQAASRGAIVAEFNIEPTPANLI--SIFYFEG 537
PA + + GA+V N +P A + F+F+G
Sbjct: 263 PAPRYLHETMRHGAVVVVVNPDPAVAEGLRDEDFFFQG 300
>UniRef50_Q03ZB1 Cluster: NAD-dependent protein deacetylase, SIR2
family; n=3; Leuconostocaceae|Rep: NAD-dependent protein
deacetylase, SIR2 family - Leuconostoc mesenteroides
subsp. mesenteroides (strain ATCC 8293 /NCDO 523)
Length = 234
Score = 41.1 bits (92), Expect = 0.021
Identities = 48/146 (32%), Positives = 68/146 (46%), Gaps = 2/146 (1%)
Frame = +1
Query: 64 QKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPR 237
Q K +ITQNVD LH +A + ++LI HG+LY +V D +SP
Sbjct: 92 QGKAKIITQNVDDLHVKAASDPEKLIRFHGSLY--------DVYAPVDGQ------KSPY 137
Query: 238 F*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTS 417
Y L ++A ALLRP I ++ E + D+ ++A + D+ ++VGTS
Sbjct: 138 QDY---------LRAMRRAD-NALLRPRITFY-EEMPFDVKKSALW-VRNADLIVIVGTS 185
Query: 418 SVVYPAAMFAPQAASRGAIVAEFNIE 495
VYP A Q AS V N E
Sbjct: 186 FKVYPFAGLL-QYASPAVPVMSINFE 210
>UniRef50_Q9FY91 Cluster: SIR2-family protein; n=12;
Magnoliophyta|Rep: SIR2-family protein - Arabidopsis
thaliana (Mouse-ear cress)
Length = 451
Score = 41.1 bits (92), Expect = 0.021
Identities = 19/33 (57%), Positives = 23/33 (69%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNLYKTRCTKC 177
+ITQNVD LH RAG+ L ELHG +Y C +C
Sbjct: 252 MITQNVDRLHHRAGSDPL-ELHGTVYTVMCLEC 283
Score = 41.1 bits (92), Expect = 0.021
Identities = 27/87 (31%), Positives = 42/87 (48%)
Frame = +1
Query: 250 GFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVY 429
GF IPV C+K C +L+P +++FG+++ + A D LV+G+S +
Sbjct: 343 GFHIPV-----CEK--CKGVLKPDVIFFGDNIPKERATQAMEVAKQSDAFLVLGSSLMTM 395
Query: 430 PAAMFAPQAASRGAIVAEFNIEPTPAN 510
A A GA+ A NI T A+
Sbjct: 396 SAFRLCRAAHEAGAMTAIVNIGETRAD 422
>UniRef50_Q95Q89 Cluster: Yeast sir related protein 2.4; n=2;
Caenorhabditis|Rep: Yeast sir related protein 2.4 -
Caenorhabditis elegans
Length = 299
Score = 41.1 bits (92), Expect = 0.021
Identities = 19/36 (52%), Positives = 24/36 (66%), Gaps = 2/36 (5%)
Frame = +1
Query: 76 TVITQNVDGLHARAG--TKRLIELHGNLYKTRCTKC 177
T+ITQNVDGL + G + LIE+HGNL+ C C
Sbjct: 119 TIITQNVDGLDRKVGIPVEDLIEVHGNLFLEVCQSC 154
>UniRef50_Q7R0G2 Cluster: GLP_29_33086_34261; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_29_33086_34261 - Giardia lamblia
ATCC 50803
Length = 391
Score = 40.7 bits (91), Expect = 0.028
Identities = 22/51 (43%), Positives = 30/51 (58%), Gaps = 2/51 (3%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGT--KRLIELHGNLYKTRC 168
GH AIAK + + VITQN+D LH ++G RL+E+HG L +C
Sbjct: 128 GHIAIAKIM----RKADVFVITQNIDTLHTKSGALENRLVEIHGRLGLYKC 174
>UniRef50_A2QUR5 Cluster: Remark: the H. sapiens SIRT4 belongs to a
group of four human SIRT proteins; n=1; Aspergillus
niger|Rep: Remark: the H. sapiens SIRT4 belongs to a
group of four human SIRT proteins - Aspergillus niger
Length = 357
Score = 40.7 bits (91), Expect = 0.028
Identities = 22/72 (30%), Positives = 36/72 (50%)
Frame = +1
Query: 277 PHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQA 456
P C + G +L+P ++ FGE+++ + AE A+ LV+G+S Y A +A
Sbjct: 240 PACPTSTAG-ILKPAVIMFGENIDPAVRLGAEEAIDDAGRLLVLGSSLATYSAWRLVERA 298
Query: 457 ASRGAIVAEFNI 492
RG + NI
Sbjct: 299 YKRGMPIGIINI 310
>UniRef50_A0D0F1 Cluster: Chromosome undetermined scaffold_33, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_33,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 264
Score = 39.9 bits (89), Expect = 0.049
Identities = 29/89 (32%), Positives = 46/89 (51%), Gaps = 2/89 (2%)
Frame = +1
Query: 79 VITQNVDGLHARAG--TKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*YGG 252
VIT NVDG +AG + + E+HG+++K +CT C ++ + + +
Sbjct: 97 VITSNVDGQFQKAGFDSNHIYEMHGSIHKFQCTPCDKLYDAHQFKDLSIDLEK----FSA 152
Query: 253 FDIPVKLLPHCKKAHCGALLRPHIVWFGE 339
D P LP C+ C LLRP+I+ FG+
Sbjct: 153 AD-P---LPKCE---CKRLLRPNILMFGD 174
>UniRef50_P06700 Cluster: NAD-dependent histone deacetylase SIR2;
n=13; Saccharomycetales|Rep: NAD-dependent histone
deacetylase SIR2 - Saccharomyces cerevisiae (Baker's
yeast)
Length = 562
Score = 39.9 bits (89), Expect = 0.049
Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 22/140 (15%)
Frame = +1
Query: 85 TQNVDGLHARAG--TKRLIELHGNLYKTRCTKCK---------EVLVNNDSPICT-CK*R 228
TQN+D L + AG T +L++ HG+ C C + N + P+C C +
Sbjct: 343 TQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKK 402
Query: 229 SPRF*YGGFDIPVKLL----------PHCKKAHCGALLRPHIVWFGESLEHDILEAAEHA 378
+ G++ V + P+ ++ +L+P I +FGE+L + ++
Sbjct: 403 RREYFPEGYNNKVGVAASQGSMSERPPYILNSY--GVLKPDITFFGEALPNKFHKSIRED 460
Query: 379 MSTCDVCLVVGTSSVVYPAA 438
+ CD+ + +GTS V P +
Sbjct: 461 ILECDLLICIGTSLKVAPVS 480
>UniRef50_Q23YS7 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 304
Score = 39.5 bits (88), Expect = 0.065
Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 3/105 (2%)
Frame = +1
Query: 67 KKITVITQNVDGLHARAG--TKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF 240
KK V+T NVDG +AG K + E+HG++ +CT C+ + + I +
Sbjct: 120 KKSFVLTSNVDGHFQKAGFDNKSVYEVHGSINFMQCTSCQRIYSADGYNII--------Y 171
Query: 241 *YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGE-SLEHDILEAAE 372
F+ LP+CK ++RP+I+ FG+ S D +E E
Sbjct: 172 DMNTFEAK-DPLPNCKNC-VNVIVRPNILMFGDYSFMSDRVEEQE 214
>UniRef50_A5DSX8 Cluster: NAD-dependent histone deacetylase SIR2;
n=1; Lodderomyces elongisporus NRRL YB-4239|Rep:
NAD-dependent histone deacetylase SIR2 - Lodderomyces
elongisporus (Yeast) (Saccharomyces elongisporus)
Length = 568
Score = 39.5 bits (88), Expect = 0.065
Identities = 33/124 (26%), Positives = 56/124 (45%), Gaps = 6/124 (4%)
Frame = +1
Query: 85 TQNVDGLHARAGT--KRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RS----PRF*Y 246
TQN+D L + AG +++++ HG+ C C+ V ++ T + + PR
Sbjct: 345 TQNIDNLESYAGIVPEKMVQCHGSFATATCVTCRNT-VAGETIFKTIRQKEIPYCPRCEA 403
Query: 247 GGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVV 426
I K + G + +P I +FGE+L + +S CD+ + +GTS V
Sbjct: 404 KKKSILKKNDDYYFPESYG-VYKPDITFFGEALPSRFHDLINTDISECDLLISIGTSLKV 462
Query: 427 YPAA 438
P A
Sbjct: 463 APVA 466
>UniRef50_A6XDL2 Cluster: Sirtuin 1; n=2; Schistosoma|Rep: Sirtuin 1
- Schistosoma mansoni (Blood fluke)
Length = 568
Score = 39.1 bits (87), Expect = 0.085
Identities = 16/32 (50%), Positives = 19/32 (59%)
Frame = +1
Query: 85 TQNVDGLHARAGTKRLIELHGNLYKTRCTKCK 180
TQN+D L AG RLI+ HG+ CT CK
Sbjct: 245 TQNIDTLEQAAGITRLIQCHGSFASATCTNCK 276
Score = 37.5 bits (83), Expect = 0.26
Identities = 21/64 (32%), Positives = 34/64 (53%)
Frame = +1
Query: 307 LLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEF 486
+L+P IV+FGE L ++ ++ + + D+ LV+G+S V P + P A R
Sbjct: 367 VLKPDIVFFGEGLSNEFHDSLSNDIKQTDLVLVIGSSLKVRPVS-HIPNAVPRQVPQILI 425
Query: 487 NIEP 498
N EP
Sbjct: 426 NREP 429
>UniRef50_Q8IKW2 Cluster: Putative uncharacterized protein; n=1;
Plasmodium falciparum 3D7|Rep: Putative uncharacterized
protein - Plasmodium falciparum (isolate 3D7)
Length = 1304
Score = 38.7 bits (86), Expect = 0.11
Identities = 16/35 (45%), Positives = 22/35 (62%), Gaps = 2/35 (5%)
Frame = +1
Query: 79 VITQNVDGLHARAGT--KRLIELHGNLYKTRCTKC 177
+ITQN+D LH R G + E+HGN++ RC C
Sbjct: 271 MITQNIDSLHHRCGKHFSKTAEIHGNIFTERCDFC 305
>UniRef50_Q2U9Y7 Cluster: Sirtuin 4 and related class II sirtuins;
n=10; Pezizomycotina|Rep: Sirtuin 4 and related class II
sirtuins - Aspergillus oryzae
Length = 407
Score = 38.3 bits (85), Expect = 0.15
Identities = 18/62 (29%), Positives = 33/62 (53%)
Frame = +1
Query: 307 LLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEF 486
+L+P ++ FGE+++ + AAE A+ L++G+S + A +A RG +
Sbjct: 303 VLKPAVIMFGENIQPAVKTAAEEAIDDAGRLLILGSSLATFSAWRLVERAHKRGMPIGII 362
Query: 487 NI 492
NI
Sbjct: 363 NI 364
Score = 34.3 bits (75), Expect = 2.4
Identities = 17/36 (47%), Positives = 21/36 (58%), Gaps = 1/36 (2%)
Frame = +1
Query: 76 TVITQNVDGLHARAGTK-RLIELHGNLYKTRCTKCK 180
+V+TQNVD H A +K IELHG L C C+
Sbjct: 166 SVVTQNVDSFHPIAHSKLSTIELHGYLRSVVCISCQ 201
>UniRef50_A2DKF0 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 347
Score = 37.9 bits (84), Expect = 0.20
Identities = 45/170 (26%), Positives = 72/170 (42%), Gaps = 3/170 (1%)
Frame = +1
Query: 25 HFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDS 204
H+ IA+ E NHG +++ +QNVD L +L +HG+ + C C + D
Sbjct: 139 HYFIAELE-NHGKLQRL--YSQNVDTLECGVPESKLRCVHGSWRNSYCLSCGKKFDIEDL 195
Query: 205 PICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGESL---EHDILEAAEH 375
+ +P C CG ++P IV+FG+ + DI +E
Sbjct: 196 REA---------------VQNGTVPTCP---CGGQIKPGIVFFGQKTNIEDEDITADSEE 237
Query: 376 AMSTCDVCLVVGTSSVVYPAAMFAPQAASRGAIVAEFNIEPTPANLISIF 525
D+ +V+GTS V P +M P+ S+ + N EP N + F
Sbjct: 238 G----DLLIVIGTSLKVAPISML-PEFFSQIPSIL-INREPVTCNFSAEF 281
>UniRef50_Q480E0 Cluster: Putative membrane protein; n=1; Colwellia
psychrerythraea 34H|Rep: Putative membrane protein -
Colwellia psychrerythraea (strain 34H / ATCC BAA-681)
(Vibriopsychroerythus)
Length = 512
Score = 37.5 bits (83), Expect = 0.26
Identities = 17/59 (28%), Positives = 30/59 (50%)
Frame = +1
Query: 280 HCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAAMFAPQA 456
HC+ HC LL+P I+ E+++ + +A + M C LV+G ++ +M A
Sbjct: 401 HCQ--HCSGLLKPQILAADENIDSECYQALQKNMMECGCLLVIGVPTITPVVSMIIENA 457
>UniRef50_A7HID4 Cluster: Silent information regulator protein Sir2;
n=9; Deltaproteobacteria|Rep: Silent information
regulator protein Sir2 - Anaeromyxobacter sp. Fw109-5
Length = 289
Score = 37.5 bits (83), Expect = 0.26
Identities = 27/92 (29%), Positives = 48/92 (52%), Gaps = 5/92 (5%)
Frame = +1
Query: 79 VITQNVDGLHARAG--TKRLIELHGNLYKTRCTK--CKEVLVN-NDSPICTCK*RSPRF* 243
V+T NVDG +AG ++++E+HG+++ +CT+ C + N D P+ R+ R
Sbjct: 107 VVTSNVDGQFQKAGFAEEQVLEVHGSIHHLQCTEPCCGTIWRNGEDVPVDEASMRARR-- 164
Query: 244 YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGE 339
+P C + H + RP+I+ FG+
Sbjct: 165 ----------IPRCIRCH--GVARPNILMFGD 184
>UniRef50_Q5KA61 Cluster: Histone deacetylase, putative; n=1;
Filobasidiella neoformans|Rep: Histone deacetylase,
putative - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 596
Score = 37.5 bits (83), Expect = 0.26
Identities = 13/33 (39%), Positives = 22/33 (66%)
Frame = +1
Query: 85 TQNVDGLHARAGTKRLIELHGNLYKTRCTKCKE 183
TQN+D L + AG +R+++ HG+ C +CK+
Sbjct: 248 TQNIDTLESLAGVERVLQCHGSFKTASCLRCKQ 280
>UniRef50_A1ZMS1 Cluster: Silent information regulator protein Sir2;
n=1; Microscilla marina ATCC 23134|Rep: Silent
information regulator protein Sir2 - Microscilla marina
ATCC 23134
Length = 276
Score = 36.7 bits (81), Expect = 0.45
Identities = 25/87 (28%), Positives = 46/87 (52%), Gaps = 3/87 (3%)
Frame = +1
Query: 82 ITQNVDGLHARAG-TK-RLIELHGNLYKTRCT-KCKEVLVNNDSPICTCK*RSPRF*YGG 252
IT N+DG H +AG TK ++ E+HG+++ +C+ C + + D+ +
Sbjct: 108 ITSNIDGQHLKAGATKDKVREVHGSIFHLQCSVPCHQEVWEGDT--------NEAIDVNN 159
Query: 253 FDIPVKLLPHCKKAHCGALLRPHIVWF 333
++ ++ LP C K CG + RP++ F
Sbjct: 160 ENLQLEDLPKCPK--CGKMSRPNVYMF 184
>UniRef50_A2DZ29 Cluster: Transcriptional regulator, Sir2 family
protein; n=4; Trichomonas vaginalis|Rep: Transcriptional
regulator, Sir2 family protein - Trichomonas vaginalis
G3
Length = 375
Score = 36.7 bits (81), Expect = 0.45
Identities = 35/124 (28%), Positives = 53/124 (42%)
Frame = +1
Query: 67 KKITVITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEVLVNNDSPICTCK*RSPRF*Y 246
K + + TQNVD L + L +HG+ ++ C C + D K PR
Sbjct: 172 KLLRLYTQNVDALDVGILPEHLRCVHGSWRESYCMTCDALHTIEDIRDSVEKGEVPR--- 228
Query: 247 GGFDIPVKLLPHCKKAHCGALLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVV 426
C CG ++P IV+FG+S+ + E E+ D+ LV+GTS V
Sbjct: 229 ------------C--IFCGGAIKPGIVFFGQSVNLNDFE-LENDAREADLLLVIGTSLRV 273
Query: 427 YPAA 438
P +
Sbjct: 274 APVS 277
>UniRef50_Q6ZMU6 Cluster: CDNA FLJ16662 fis, clone TESTI4046240,
highly similar to Homo sapiens sirtuin 7; n=1; Homo
sapiens|Rep: CDNA FLJ16662 fis, clone TESTI4046240,
highly similar to Homo sapiens sirtuin 7 - Homo sapiens
(Human)
Length = 162
Score = 36.7 bits (81), Expect = 0.45
Identities = 16/28 (57%), Positives = 21/28 (75%), Gaps = 2/28 (7%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKR--LIELHGNLY 156
V++QN DGLH R+G R + ELHGN+Y
Sbjct: 15 VVSQNCDGLHLRSGLPRTAISELHGNMY 42
>UniRef50_Q8SSB6 Cluster: SIR2-LIKE PROTEIN INVOLVED IN TELOMERIC
SILENCING; n=1; Encephalitozoon cuniculi|Rep: SIR2-LIKE
PROTEIN INVOLVED IN TELOMERIC SILENCING -
Encephalitozoon cuniculi
Length = 425
Score = 36.7 bits (81), Expect = 0.45
Identities = 42/151 (27%), Positives = 66/151 (43%), Gaps = 9/151 (5%)
Frame = +1
Query: 4 KANYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAG---TK----RLIELHGNLYKT 162
KA +A H ++ + D ++ + TQN+DGL +AG TK RL+ LHGN+
Sbjct: 154 KAQPSATHEFLSLYSD---ISRRFRIYTQNIDGLEEKAGLAATKDRSTRLVYLHGNMKSL 210
Query: 163 RCTKCKEVLVNNDSPICTCK*RSPRF*YGGFDIPVKLLPHCKKAHCGALLRPHIVWFGES 342
C C + D+ G K +K G + I+ + +S
Sbjct: 211 GCLYCGYKIEFGDAERDAYGRGEEIVCAGCVRRNEKRGRDVRKRPVG-VFHTTIIHYNQS 269
Query: 343 LEHD--ILEAAEHAMSTCDVCLVVGTSSVVY 429
I + AEH +TCD+ +V+GTS V+
Sbjct: 270 HPDSSFISKMAEHD-NTCDLFIVMGTSLKVF 299
>UniRef50_Q5CYK0 Cluster: Bacterial-like Sir2 family protein; n=2;
Cryptosporidium|Rep: Bacterial-like Sir2 family protein
- Cryptosporidium parvum Iowa II
Length = 299
Score = 35.9 bits (79), Expect = 0.79
Identities = 19/51 (37%), Positives = 30/51 (58%), Gaps = 2/51 (3%)
Frame = +1
Query: 22 GHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTKR--LIELHGNLYKTRC 168
GH ++K + + +I VITQN+DGL + R +IE+HG ++ RC
Sbjct: 97 GHRVLSKLCSDFPN--RIKVITQNIDGLMQQTNCPRENIIEIHGRIHYLRC 145
>UniRef50_Q6CAJ8 Cluster: Similar to sp|P53687 Saccharomyces
cerevisiae HST3 protein; n=1; Yarrowia lipolytica|Rep:
Similar to sp|P53687 Saccharomyces cerevisiae HST3
protein - Yarrowia lipolytica (Candida lipolytica)
Length = 385
Score = 35.9 bits (79), Expect = 0.79
Identities = 21/60 (35%), Positives = 32/60 (53%), Gaps = 2/60 (3%)
Frame = +1
Query: 16 TAGHFAIAKFEDNHGSQKKITVITQNVDGLHARA--GTKRLIELHGNLYKTRCTKCKEVL 189
T H +AK D G K ++ TQN+D L + K++++LHG+L C +C E L
Sbjct: 108 TRVHEFVAKL-DTAG--KLLSCYTQNIDSLEHKTEVSAKKIVQLHGHLDTLNCIQCSEKL 164
>UniRef50_O94640 Cluster: NAD-dependent histone deacetylase sir2;
n=1; Schizosaccharomyces pombe|Rep: NAD-dependent
histone deacetylase sir2 - Schizosaccharomyces pombe
(Fission yeast)
Length = 475
Score = 35.9 bits (79), Expect = 0.79
Identities = 19/59 (32%), Positives = 29/59 (49%), Gaps = 2/59 (3%)
Frame = +1
Query: 10 NYTAGHFAIAKFEDNHGSQKKITVITQNVDGLHARAGTK--RLIELHGNLYKTRCTKCK 180
+Y+ H I E + K T+ TQN+D L + G ++I+ HG+ C KCK
Sbjct: 223 HYSPSHAFIRLLEKKN---KLSTLFTQNIDNLEKKTGLSDNKIIQCHGSFATATCIKCK 278
>UniRef50_A6Q178 Cluster: Transcription regulator, Sir2 family; n=1;
Nitratiruptor sp. SB155-2|Rep: Transcription regulator,
Sir2 family - Nitratiruptor sp. (strain SB155-2)
Length = 234
Score = 35.5 bits (78), Expect = 1.1
Identities = 17/35 (48%), Positives = 22/35 (62%)
Frame = +1
Query: 82 ITQNVDGLHARAGTKRLIELHGNLYKTRCTKCKEV 186
+TQNVD L +AG I LHG L + RC CK++
Sbjct: 87 LTQNVDDLCEKAGDNP-IHLHGKLTEIRCEVCKKI 120
>UniRef50_Q7QZ36 Cluster: GLP_464_21655_23334; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_464_21655_23334 - Giardia lamblia
ATCC 50803
Length = 559
Score = 35.5 bits (78), Expect = 1.1
Identities = 15/44 (34%), Positives = 26/44 (59%)
Frame = +1
Query: 307 LLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
+L+P I++FGE L D+ E + S D+ + +G+S V P +
Sbjct: 414 ILKPQIIFFGEKLSSDLEEFIDDDCSVADMFIAIGSSLRVKPVS 457
>UniRef50_Q7S6G9 Cluster: Putative uncharacterized protein
NCU04737.1; n=3; Sordariomycetes|Rep: Putative
uncharacterized protein NCU04737.1 - Neurospora crassa
Length = 670
Score = 35.1 bits (77), Expect = 1.4
Identities = 18/52 (34%), Positives = 28/52 (53%), Gaps = 1/52 (1%)
Frame = +1
Query: 298 CGALLRPHIVWFGESLEHDI-LEAAEHAMSTCDVCLVVGTSSVVYPAAMFAP 450
CG +++P I +FGE+L + EH D+ +V+GTS V P + P
Sbjct: 422 CG-VMKPDITFFGEALPDEFSTRLTEHDRDLVDLVIVIGTSLKVAPVSEVVP 472
Score = 34.7 bits (76), Expect = 1.8
Identities = 15/39 (38%), Positives = 23/39 (58%), Gaps = 2/39 (5%)
Frame = +1
Query: 67 KKITVITQNVDGLHARAG--TKRLIELHGNLYKTRCTKC 177
K +T +QN+D L A+AG +L++ HG+ C KC
Sbjct: 290 KLLTNYSQNIDNLEAKAGIHPDKLVQCHGSFATATCVKC 328
>UniRef50_Q0CR31 Cluster: NAD-dependent histone deacetylase SIR2;
n=2; Pezizomycotina|Rep: NAD-dependent histone
deacetylase SIR2 - Aspergillus terreus (strain NIH 2624)
Length = 1068
Score = 35.1 bits (77), Expect = 1.4
Identities = 14/39 (35%), Positives = 23/39 (58%), Gaps = 2/39 (5%)
Frame = +1
Query: 67 KKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKC 177
K +T TQN+D + A AG +++++ HG+ C KC
Sbjct: 260 KLLTNYTQNIDNIEANAGVVPEKIVQCHGSFATATCVKC 298
>UniRef50_A4A980 Cluster: NAD-dependent deacetylase; n=5;
Gammaproteobacteria|Rep: NAD-dependent deacetylase -
Congregibacter litoralis KT71
Length = 241
Score = 34.7 bits (76), Expect = 1.8
Identities = 14/25 (56%), Positives = 18/25 (72%)
Frame = +1
Query: 79 VITQNVDGLHARAGTKRLIELHGNL 153
+ITQN+DGL +AG K I +HG L
Sbjct: 80 LITQNIDGLDGKAGNKDYIAIHGRL 104
>UniRef50_A2Q9C4 Cluster: Contig An01c0250, complete genome; n=18;
Pezizomycotina|Rep: Contig An01c0250, complete genome -
Aspergillus niger
Length = 495
Score = 34.7 bits (76), Expect = 1.8
Identities = 14/40 (35%), Positives = 23/40 (57%), Gaps = 2/40 (5%)
Frame = +1
Query: 67 KKITVITQNVDGLHARAGT--KRLIELHGNLYKTRCTKCK 180
K +T TQN+D + A AG + +++ HG+ C KC+
Sbjct: 262 KLLTNYTQNIDNIEANAGVLPENIVQCHGSFATATCVKCQ 301
>UniRef50_A5C953 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 362
Score = 33.9 bits (74), Expect = 3.2
Identities = 18/51 (35%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Frame = -1
Query: 250 HHIRIWGSSICKCI*GCHYSPILPY-ILYIEFCINFHEALSIFSFLLWHVN 101
HH +W + C+ C+Y L + ILY++ IN ALS+ F++ HV+
Sbjct: 226 HHC-VW---VVNCVGACNYKFFLLFLILYLDAVINLAFALSLLCFIVMHVS 272
>UniRef50_Q5AQ47 Cluster: Potential Sir2 family histone deacetylase;
n=2; Candida albicans|Rep: Potential Sir2 family histone
deacetylase - Candida albicans (Yeast)
Length = 657
Score = 33.9 bits (74), Expect = 3.2
Identities = 16/44 (36%), Positives = 25/44 (56%)
Frame = +1
Query: 307 LLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
+++P I +FGE L + A ++ D+ LV+GTS V P A
Sbjct: 495 VMKPDITFFGEQLPENFKIAINQDINKVDLVLVIGTSLKVAPVA 538
>UniRef50_Q2H5A0 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 387
Score = 33.9 bits (74), Expect = 3.2
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Frame = +1
Query: 79 VITQNVDGLHARAGTK--RLIELHGNLYKTRCTKCK 180
+ TQN+D L AG R++E HG+ RC CK
Sbjct: 123 LFTQNIDCLERAAGVPADRIVEAHGSFASQRCVDCK 158
>UniRef50_A6SFT5 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 224
Score = 33.1 bits (72), Expect = 5.6
Identities = 18/38 (47%), Positives = 25/38 (65%), Gaps = 3/38 (7%)
Frame = +1
Query: 310 LRPHIVWFGESLEHD--ILEAAEHAMSTCDV-CLVVGT 414
LRP+++ +GE D ILEAA+H + C V L+VGT
Sbjct: 130 LRPNVLLYGEPHPDDKEILEAAKHGLRICPVLVLIVGT 167
>UniRef50_Q874C2 Cluster: Cation-transporting ATPase; n=1; Trametes
versicolor|Rep: Cation-transporting ATPase - Trametes
versicolor (White-rot fungus) (Coriolus versicolor)
Length = 983
Score = 32.7 bits (71), Expect = 7.4
Identities = 12/38 (31%), Positives = 21/38 (55%)
Frame = +1
Query: 307 LLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSS 420
L P + W G+ + ++ +H +T DV + +GTSS
Sbjct: 253 LTTPALFWLGQKFYRNAYKSLKHGSATMDVLIAIGTSS 290
>UniRef50_Q55PY8 Cluster: Putative uncharacterized protein; n=2;
Filobasidiella neoformans|Rep: Putative uncharacterized
protein - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 361
Score = 32.7 bits (71), Expect = 7.4
Identities = 19/39 (48%), Positives = 23/39 (58%), Gaps = 7/39 (17%)
Frame = +1
Query: 79 VITQNVDGLHARA------GTK-RLIELHGNLYKTRCTK 174
+ITQNVD LH +A TK ++ELHG L K C K
Sbjct: 129 LITQNVDNLHPKAYRLLSPNTKPPILELHGTLAKVHCMK 167
>UniRef50_A7TQE2 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 602
Score = 32.7 bits (71), Expect = 7.4
Identities = 14/44 (31%), Positives = 24/44 (54%)
Frame = +1
Query: 307 LLRPHIVWFGESLEHDILEAAEHAMSTCDVCLVVGTSSVVYPAA 438
+++P I +FGE L + E + CD+ + +GTS V P +
Sbjct: 481 VMKPDITFFGEPLPDKFHNSIEKDVKGCDLLICIGTSLKVSPVS 524
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 694,284,071
Number of Sequences: 1657284
Number of extensions: 14928042
Number of successful extensions: 33793
Number of sequences better than 10.0: 254
Number of HSP's better than 10.0 without gapping: 32275
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 33672
length of database: 575,637,011
effective HSP length: 97
effective length of database: 414,880,463
effective search space used: 46051731393
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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