Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= wdS30294
(753 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein. 143 7e-34
CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein. 142 1e-33
CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein. 142 1e-33
BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein pr... 142 1e-33
BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenas... 142 1e-33
BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein. 142 1e-33
AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitr... 142 1e-33
AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitra... 142 1e-33
AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein. 142 1e-33
DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenas... 140 6e-33
X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase... 136 8e-32
BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenas... 136 8e-32
BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenas... 136 8e-32
AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenas... 136 8e-32
U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase ... 133 6e-31
U62389-1|AAB17375.1| 154|Homo sapiens putative cytosolic NADP-d... 131 2e-30
>CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 143 bits (346), Expect = 7e-34
Identities = 65/94 (69%), Positives = 81/94 (86%)
Frame = +3
Query: 3 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 182
KI G VV++ GDEMTRIIW+LIKEKLI+P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 183 IKKYNVGIKCATITPDEKRVEEFK*RKCGKALMG 284
IKK+NVG+KCATITPDEKRVEEFK ++ K+ G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNG 97
Score = 138 bits (334), Expect = 2e-32
Identities = 60/86 (69%), Positives = 74/86 (86%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+K+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW +PIIIGRHA+ DQY+ATDFVVP
Sbjct: 88 LKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVEPIIIGRHAYGDQYRATDFVVP 147
Query: 434 GAGTLEIIFKPESG-EAIKHVVHEYK 508
G G +EI + P G + + ++VH ++
Sbjct: 148 GPGKVEITYTPSDGTQKVTYLVHNFE 173
Score = 131 bits (317), Expect = 2e-30
Identities = 58/79 (73%), Positives = 67/79 (84%)
Frame = +1
Query: 505 QGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDR 684
+G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+IYD+
Sbjct: 174 EGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDK 233
Query: 685 EYKKQFEDAGIWYEHRLID 741
+YK QFE IWYEHRLID
Sbjct: 234 QYKSQFEAQKIWYEHRLID 252
>CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 142 bits (344), Expect = 1e-33
Identities = 65/94 (69%), Positives = 80/94 (85%)
Frame = +3
Query: 3 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 182
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 183 IKKYNVGIKCATITPDEKRVEEFK*RKCGKALMG 284
IKK+NVG+KCATITPDEKRVEEFK ++ K+ G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNG 97
Score = 140 bits (338), Expect = 6e-33
Identities = 61/86 (70%), Positives = 74/86 (86%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+K+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 88 LKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVP 147
Query: 434 GAGTLEIIFKPESG-EAIKHVVHEYK 508
G G +EI + P G + + ++VH ++
Sbjct: 148 GPGKVEITYTPSDGTQKVTYLVHNFE 173
Score = 131 bits (317), Expect = 2e-30
Identities = 58/79 (73%), Positives = 67/79 (84%)
Frame = +1
Query: 505 QGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDR 684
+G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+IYD+
Sbjct: 174 EGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDK 233
Query: 685 EYKKQFEDAGIWYEHRLID 741
+YK QFE IWYEHRLID
Sbjct: 234 QYKSQFEAQKIWYEHRLID 252
>CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 142 bits (344), Expect = 1e-33
Identities = 65/94 (69%), Positives = 80/94 (85%)
Frame = +3
Query: 3 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 182
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 183 IKKYNVGIKCATITPDEKRVEEFK*RKCGKALMG 284
IKK+NVG+KCATITPDEKRVEEFK ++ K+ G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNG 97
Score = 138 bits (335), Expect = 1e-32
Identities = 60/86 (69%), Positives = 74/86 (86%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+K+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 88 LKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVP 147
Query: 434 GAGTLEIIFKPESG-EAIKHVVHEYK 508
G G +E+ + P G + + ++VH ++
Sbjct: 148 GPGKVEMTYTPSDGTQKVTYLVHNFE 173
Score = 131 bits (317), Expect = 2e-30
Identities = 58/79 (73%), Positives = 67/79 (84%)
Frame = +1
Query: 505 QGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDR 684
+G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+IYD+
Sbjct: 174 EGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDK 233
Query: 685 EYKKQFEDAGIWYEHRLID 741
+YK QFE IWYEHRLID
Sbjct: 234 QYKSQFEAQKIWYEHRLID 252
>BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein
protein.
Length = 414
Score = 142 bits (344), Expect = 1e-33
Identities = 65/94 (69%), Positives = 80/94 (85%)
Frame = +3
Query: 3 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 182
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 183 IKKYNVGIKCATITPDEKRVEEFK*RKCGKALMG 284
IKK+NVG+KCATITPDEKRVEEFK ++ K+ G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNG 97
Score = 138 bits (334), Expect = 2e-32
Identities = 61/83 (73%), Positives = 72/83 (86%), Gaps = 1/83 (1%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+K+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 88 LKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVP 147
Query: 434 GAGTLEIIFKPESG-EAIKHVVH 499
G G +EI + P G + + ++VH
Sbjct: 148 GPGKVEITYTPSDGTQKVTYLVH 170
Score = 130 bits (315), Expect = 4e-30
Identities = 58/78 (74%), Positives = 66/78 (84%)
Frame = +1
Query: 508 GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDRE 687
G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+IYD++
Sbjct: 175 GGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQ 234
Query: 688 YKKQFEDAGIWYEHRLID 741
YK QFE IWYEHRLID
Sbjct: 235 YKSQFEAQKIWYEHRLID 252
>BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenase 1
(NADP+), soluble protein.
Length = 414
Score = 142 bits (344), Expect = 1e-33
Identities = 65/94 (69%), Positives = 80/94 (85%)
Frame = +3
Query: 3 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 182
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 183 IKKYNVGIKCATITPDEKRVEEFK*RKCGKALMG 284
IKK+NVG+KCATITPDEKRVEEFK ++ K+ G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNG 97
Score = 140 bits (338), Expect = 6e-33
Identities = 61/86 (70%), Positives = 74/86 (86%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+K+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 88 LKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVP 147
Query: 434 GAGTLEIIFKPESG-EAIKHVVHEYK 508
G G +EI + P G + + ++VH ++
Sbjct: 148 GPGKVEITYTPSDGTQKVTYLVHNFE 173
Score = 131 bits (317), Expect = 2e-30
Identities = 58/79 (73%), Positives = 67/79 (84%)
Frame = +1
Query: 505 QGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDR 684
+G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+IYD+
Sbjct: 174 EGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDK 233
Query: 685 EYKKQFEDAGIWYEHRLID 741
+YK QFE IWYEHRLID
Sbjct: 234 QYKSQFEAQKIWYEHRLID 252
>BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein.
Length = 414
Score = 142 bits (344), Expect = 1e-33
Identities = 65/94 (69%), Positives = 80/94 (85%)
Frame = +3
Query: 3 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 182
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 183 IKKYNVGIKCATITPDEKRVEEFK*RKCGKALMG 284
IKK+NVG+KCATITPDEKRVEEFK ++ K+ G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNG 97
Score = 140 bits (338), Expect = 6e-33
Identities = 61/86 (70%), Positives = 74/86 (86%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+K+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 88 LKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVP 147
Query: 434 GAGTLEIIFKPESG-EAIKHVVHEYK 508
G G +EI + P G + + ++VH ++
Sbjct: 148 GPGKVEITYTPSDGTQKVTYLVHNFE 173
Score = 131 bits (317), Expect = 2e-30
Identities = 58/79 (73%), Positives = 67/79 (84%)
Frame = +1
Query: 505 QGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDR 684
+G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+IYD+
Sbjct: 174 EGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDK 233
Query: 685 EYKKQFEDAGIWYEHRLID 741
+YK QFE IWYEHRLID
Sbjct: 234 QYKSQFEAQKIWYEHRLID 252
>AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 142 bits (344), Expect = 1e-33
Identities = 65/94 (69%), Positives = 80/94 (85%)
Frame = +3
Query: 3 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 182
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 183 IKKYNVGIKCATITPDEKRVEEFK*RKCGKALMG 284
IKK+NVG+KCATITPDEKRVEEFK ++ K+ G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNG 97
Score = 140 bits (338), Expect = 6e-33
Identities = 61/86 (70%), Positives = 74/86 (86%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+K+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 88 LKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVP 147
Query: 434 GAGTLEIIFKPESG-EAIKHVVHEYK 508
G G +EI + P G + + ++VH ++
Sbjct: 148 GPGKVEITYTPSDGTQKVTYLVHNFE 173
Score = 131 bits (317), Expect = 2e-30
Identities = 58/79 (73%), Positives = 67/79 (84%)
Frame = +1
Query: 505 QGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDR 684
+G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+IYD+
Sbjct: 174 EGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDK 233
Query: 685 EYKKQFEDAGIWYEHRLID 741
+YK QFE IWYEHRLID
Sbjct: 234 QYKSQFEAQKIWYEHRLID 252
>AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 142 bits (344), Expect = 1e-33
Identities = 65/94 (69%), Positives = 80/94 (85%)
Frame = +3
Query: 3 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 182
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 183 IKKYNVGIKCATITPDEKRVEEFK*RKCGKALMG 284
IKK+NVG+KCATITPDEKRVEEFK ++ K+ G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNG 97
Score = 140 bits (338), Expect = 6e-33
Identities = 61/86 (70%), Positives = 74/86 (86%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+K+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 88 LKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVP 147
Query: 434 GAGTLEIIFKPESG-EAIKHVVHEYK 508
G G +EI + P G + + ++VH ++
Sbjct: 148 GPGKVEITYTPSDGTQKVTYLVHNFE 173
Score = 128 bits (309), Expect = 2e-29
Identities = 57/79 (72%), Positives = 66/79 (83%)
Frame = +1
Query: 505 QGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDR 684
+G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILK YDGRFKDIFQ+IYD+
Sbjct: 174 EGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKIYDGRFKDIFQEIYDK 233
Query: 685 EYKKQFEDAGIWYEHRLID 741
+YK QFE IWYEHRLID
Sbjct: 234 QYKSQFEAQKIWYEHRLID 252
>AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein.
Length = 414
Score = 142 bits (344), Expect = 1e-33
Identities = 65/94 (69%), Positives = 80/94 (85%)
Frame = +3
Query: 3 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEA 182
KI G VV++ GDEMTRIIW+LIKEKLI P+++++LH YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 183 IKKYNVGIKCATITPDEKRVEEFK*RKCGKALMG 284
IKK+NVG+KCATITPDEKRVEEFK ++ K+ G
Sbjct: 64 IKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNG 97
Score = 140 bits (338), Expect = 6e-33
Identities = 61/86 (70%), Positives = 74/86 (86%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+K+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 88 LKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVP 147
Query: 434 GAGTLEIIFKPESG-EAIKHVVHEYK 508
G G +EI + P G + + ++VH ++
Sbjct: 148 GPGKVEITYTPSDGTQKVTYLVHNFE 173
Score = 131 bits (317), Expect = 2e-30
Identities = 58/79 (73%), Positives = 67/79 (84%)
Frame = +1
Query: 505 QGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDR 684
+G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+IYD+
Sbjct: 174 EGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDK 233
Query: 685 EYKKQFEDAGIWYEHRLID 741
+YK QFE IWYEHRLID
Sbjct: 234 QYKSQFEAQKIWYEHRLID 252
>DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenase 1
protein.
Length = 371
Score = 140 bits (338), Expect = 6e-33
Identities = 61/86 (70%), Positives = 74/86 (86%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+K+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVP
Sbjct: 59 LKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVP 118
Query: 434 GAGTLEIIFKPESG-EAIKHVVHEYK 508
G G +EI + P G + + ++VH ++
Sbjct: 119 GPGKVEITYTPSDGTQKVTYLVHNFE 144
Score = 131 bits (317), Expect = 2e-30
Identities = 58/79 (73%), Positives = 67/79 (84%)
Frame = +1
Query: 505 QGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDR 684
+G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+IYD+
Sbjct: 145 EGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDK 204
Query: 685 EYKKQFEDAGIWYEHRLID 741
+YK QFE IWYEHRLID
Sbjct: 205 QYKSQFEAQKIWYEHRLID 223
Score = 102 bits (245), Expect = 1e-21
Identities = 46/68 (67%), Positives = 58/68 (85%)
Frame = +3
Query: 81 LILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFK*R 260
LI P+++++LH YDLG+ENRD T+DQVT D AEAIKK+NVG+KCATITPDEKRVEEFK +
Sbjct: 1 LIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLK 60
Query: 261 KCGKALMG 284
+ K+ G
Sbjct: 61 QMWKSPNG 68
>X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase
(NADP+) protein.
Length = 452
Score = 136 bits (329), Expect = 8e-32
Identities = 59/78 (75%), Positives = 65/78 (83%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+KKMWKSPNGTIRNILGGTVFRE IICKNIPRLV GW KPI IGRHAH DQYKATDFV
Sbjct: 128 LKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVAD 187
Query: 434 GAGTLEIIFKPESGEAIK 487
AGT +++F P+ G +K
Sbjct: 188 RAGTFKMVFTPKDGSGVK 205
Score = 128 bits (308), Expect = 3e-29
Identities = 61/91 (67%), Positives = 73/91 (80%)
Frame = +3
Query: 12 AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKK 191
A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQVTID A A +K
Sbjct: 47 AKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQK 106
Query: 192 YNVGIKCATITPDEKRVEEFK*RKCGKALMG 284
Y+V +KCATITPDE RVEEFK +K K+ G
Sbjct: 107 YSVAVKCATITPDEARVEEFKLKKMWKSPNG 137
Score = 118 bits (285), Expect = 2e-26
Identities = 50/76 (65%), Positives = 62/76 (81%)
Frame = +1
Query: 514 GVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYK 693
GV + M+NTD SI FAHS F++A+ +K+PLY+STKNTILK YDGRFKDIFQ+I+D+ YK
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYK 275
Query: 694 KQFEDAGIWYEHRLID 741
F+ IWYEHRLID
Sbjct: 276 TDFDKNKIWYEHRLID 291
>BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 136 bits (329), Expect = 8e-32
Identities = 59/78 (75%), Positives = 65/78 (83%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+KKMWKSPNGTIRNILGGTVFRE IICKNIPRLV GW KPI IGRHAH DQYKATDFV
Sbjct: 128 LKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVAD 187
Query: 434 GAGTLEIIFKPESGEAIK 487
AGT +++F P+ G +K
Sbjct: 188 RAGTFKMVFTPKDGSGVK 205
Score = 128 bits (308), Expect = 3e-29
Identities = 61/91 (67%), Positives = 73/91 (80%)
Frame = +3
Query: 12 AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKK 191
A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQVTID A A +K
Sbjct: 47 AKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQK 106
Query: 192 YNVGIKCATITPDEKRVEEFK*RKCGKALMG 284
Y+V +KCATITPDE RVEEFK +K K+ G
Sbjct: 107 YSVAVKCATITPDEARVEEFKLKKMWKSPNG 137
Score = 118 bits (285), Expect = 2e-26
Identities = 50/76 (65%), Positives = 62/76 (81%)
Frame = +1
Query: 514 GVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYK 693
GV + M+NTD SI FAHS F++A+ +K+PLY+STKNTILK YDGRFKDIFQ+I+D+ YK
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYK 275
Query: 694 KQFEDAGIWYEHRLID 741
F+ IWYEHRLID
Sbjct: 276 TDFDKNKIWYEHRLID 291
>BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 136 bits (329), Expect = 8e-32
Identities = 59/78 (75%), Positives = 65/78 (83%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+KKMWKSPNGTIRNILGGTVFRE IICKNIPRLV GW KPI IGRHAH DQYKATDFV
Sbjct: 128 LKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVAD 187
Query: 434 GAGTLEIIFKPESGEAIK 487
AGT +++F P+ G +K
Sbjct: 188 RAGTFKMVFTPKDGSGVK 205
Score = 128 bits (308), Expect = 3e-29
Identities = 61/91 (67%), Positives = 73/91 (80%)
Frame = +3
Query: 12 AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKK 191
A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQVTID A A +K
Sbjct: 47 AKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQK 106
Query: 192 YNVGIKCATITPDEKRVEEFK*RKCGKALMG 284
Y+V +KCATITPDE RVEEFK +K K+ G
Sbjct: 107 YSVAVKCATITPDEARVEEFKLKKMWKSPNG 137
Score = 118 bits (285), Expect = 2e-26
Identities = 50/76 (65%), Positives = 62/76 (81%)
Frame = +1
Query: 514 GVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYK 693
GV + M+NTD SI FAHS F++A+ +K+PLY+STKNTILK YDGRFKDIFQ+I+D+ YK
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYK 275
Query: 694 KQFEDAGIWYEHRLID 741
F+ IWYEHRLID
Sbjct: 276 TDFDKNKIWYEHRLID 291
>AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial precursor variant protein.
Length = 452
Score = 136 bits (329), Expect = 8e-32
Identities = 59/78 (75%), Positives = 65/78 (83%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+KKMWKSPNGTIRNILGGTVFRE IICKNIPRLV GW KPI IGRHAH DQYKATDFV
Sbjct: 128 LKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVAD 187
Query: 434 GAGTLEIIFKPESGEAIK 487
AGT +++F P+ G +K
Sbjct: 188 RAGTFKMVFTPKDGSGVK 205
Score = 128 bits (308), Expect = 3e-29
Identities = 61/91 (67%), Positives = 73/91 (80%)
Frame = +3
Query: 12 AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKK 191
A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQVTID A A +K
Sbjct: 47 AKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQK 106
Query: 192 YNVGIKCATITPDEKRVEEFK*RKCGKALMG 284
Y+V +KCATITPDE RVEEFK +K K+ G
Sbjct: 107 YSVAVKCATITPDEARVEEFKLKKMWKSPNG 137
Score = 117 bits (281), Expect = 5e-26
Identities = 49/76 (64%), Positives = 62/76 (81%)
Frame = +1
Query: 514 GVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYK 693
GV + M+NTD SI FAHS F++A+ +K+PLY+STKNTILK YDGRFKDIFQ+I+D+ Y+
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYE 275
Query: 694 KQFEDAGIWYEHRLID 741
F+ IWYEHRLID
Sbjct: 276 TDFDKNKIWYEHRLID 291
>U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase
protein.
Length = 419
Score = 133 bits (322), Expect = 6e-31
Identities = 58/78 (74%), Positives = 64/78 (82%)
Frame = +2
Query: 254 MKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVP 433
+KKMWKSPNGTIRNI GGTVFRE IICKNIPRLV GW KPI IGRHAH DQYKATDFV
Sbjct: 95 LKKMWKSPNGTIRNIHGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVAD 154
Query: 434 GAGTLEIIFKPESGEAIK 487
AGT +++F P+ G +K
Sbjct: 155 RAGTFKMVFTPKDGSGVK 172
Score = 118 bits (285), Expect = 2e-26
Identities = 50/76 (65%), Positives = 62/76 (81%)
Frame = +1
Query: 514 GVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDREYK 693
GV + M+NTD SI FAHS F++A+ +K+PLY+STKNTILK YDGRFKDIFQ+I+D+ YK
Sbjct: 183 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYK 242
Query: 694 KQFEDAGIWYEHRLID 741
F+ IWYEHRLID
Sbjct: 243 TDFDKNKIWYEHRLID 258
Score = 87.0 bits (206), Expect = 6e-17
Identities = 40/63 (63%), Positives = 50/63 (79%)
Frame = +3
Query: 96 LDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFK*RKCGKA 275
LD++L +DLG+ NRD+TDDQVTID A A +KY+V +KCATITPDE RVEEFK +K K+
Sbjct: 42 LDVQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKS 101
Query: 276 LMG 284
G
Sbjct: 102 PNG 104
>U62389-1|AAB17375.1| 154|Homo sapiens putative cytosolic
NADP-dependent isocitrate dehydrogenase protein.
Length = 154
Score = 131 bits (317), Expect = 2e-30
Identities = 58/79 (73%), Positives = 67/79 (84%)
Frame = +1
Query: 505 QGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFKDIFQDIYDR 684
+G GVA+ M+N D SI DFAHSSF+ AL + +PLYLSTKNTILKKYDGRFKDIFQ+IYD+
Sbjct: 75 EGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDK 134
Query: 685 EYKKQFEDAGIWYEHRLID 741
+YK QFE IWYEHRLID
Sbjct: 135 QYKSQFEAQKIWYEHRLID 153
Score = 113 bits (271), Expect = 9e-25
Identities = 50/74 (67%), Positives = 61/74 (82%), Gaps = 1/74 (1%)
Frame = +2
Query: 290 RNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPE 469
RNILGGTVF EAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVPG G +EI + P
Sbjct: 1 RNILGGTVFXEAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPS 60
Query: 470 SG-EAIKHVVHEYK 508
G + + ++VH ++
Sbjct: 61 DGTQKVTYLVHNFE 74
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 107,828,759
Number of Sequences: 237096
Number of extensions: 2242322
Number of successful extensions: 4334
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 4126
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4334
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 9071127468
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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