Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= wdS20990
(768 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenas... 171 3e-42
CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein. 171 3e-42
CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein. 171 3e-42
BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenas... 171 3e-42
BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein. 171 3e-42
AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitr... 171 3e-42
AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein. 171 3e-42
X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase... 170 5e-42
BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein pr... 170 5e-42
BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenas... 170 5e-42
BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenas... 170 5e-42
AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenas... 170 5e-42
AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitra... 170 5e-42
CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein. 169 9e-42
U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase ... 167 4e-41
U62389-1|AAB17375.1| 154|Homo sapiens putative cytosolic NADP-d... 83 8e-16
AK128134-1|BAC87289.1| 377|Homo sapiens member 6 (SLC12A6). pr... 30 7.9
>DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenase 1
protein.
Length = 371
Score = 171 bits (415), Expect = 3e-42
Identities = 89/172 (51%), Positives = 110/172 (63%), Gaps = 3/172 (1%)
Frame = +1
Query: 256 HRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTV 435
+RDAT+DQVT D+A AI KHNVG+KCATITPDE+RVEEFKLK+MW SPNGTIRNILGGTV
Sbjct: 19 NRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTV 78
Query: 436 FREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRKILLYRNPERLNLFTLHEMVRQRGVY 615
FRE I+C++IPR+V GW KPI+IG R + P ++ + T + V
Sbjct: 79 FREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEI-TYTPSDGTQKVT 137
Query: 616 YMILKLR---ALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILKR 762
Y++ + FQ+AL K WPLYLSTKNTILK+
Sbjct: 138 YLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKK 189
Score = 83.4 bits (197), Expect = 8e-16
Identities = 40/65 (61%), Positives = 50/65 (76%), Gaps = 2/65 (3%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTE-RRVLYDFKT-PGVAMGMYNTDESIRSF 683
HA+GDQY+A DFVVP PGKVE+ YT DGT + ++++F+ GVAMGMYN D+SI F
Sbjct: 104 HAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDF 163
Query: 684 AHSSF 698
AHSSF
Sbjct: 164 AHSSF 168
>CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 171 bits (415), Expect = 3e-42
Identities = 89/172 (51%), Positives = 110/172 (63%), Gaps = 3/172 (1%)
Frame = +1
Query: 256 HRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTV 435
+RDAT+DQVT D+A AI KHNVG+KCATITPDE+RVEEFKLK+MW SPNGTIRNILGGTV
Sbjct: 48 NRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTV 107
Query: 436 FREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRKILLYRNPERLNLFTLHEMVRQRGVY 615
FRE I+C++IPR+V GW KPI+IG R + P ++ + T + V
Sbjct: 108 FREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEI-TYTPSDGTQKVT 166
Query: 616 YMILKLR---ALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILKR 762
Y++ + FQ+AL K WPLYLSTKNTILK+
Sbjct: 167 YLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKK 218
Score = 83.4 bits (197), Expect = 8e-16
Identities = 40/65 (61%), Positives = 50/65 (76%), Gaps = 2/65 (3%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTE-RRVLYDFKT-PGVAMGMYNTDESIRSF 683
HA+GDQY+A DFVVP PGKVE+ YT DGT + ++++F+ GVAMGMYN D+SI F
Sbjct: 133 HAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDF 192
Query: 684 AHSSF 698
AHSSF
Sbjct: 193 AHSSF 197
Score = 58.4 bits (135), Expect = 3e-08
Identities = 25/42 (59%), Positives = 33/42 (78%)
Frame = +2
Query: 128 VAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGL 253
++ VVEM GDEMTRI+W IKE+LIFPYV++D +DLG+
Sbjct: 5 ISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGI 46
>CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 171 bits (415), Expect = 3e-42
Identities = 89/172 (51%), Positives = 110/172 (63%), Gaps = 3/172 (1%)
Frame = +1
Query: 256 HRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTV 435
+RDAT+DQVT D+A AI KHNVG+KCATITPDE+RVEEFKLK+MW SPNGTIRNILGGTV
Sbjct: 48 NRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTV 107
Query: 436 FREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRKILLYRNPERLNLFTLHEMVRQRGVY 615
FRE I+C++IPR+V GW KPI+IG R + P ++ + T + V
Sbjct: 108 FREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEM-TYTPSDGTQKVT 166
Query: 616 YMILKLR---ALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILKR 762
Y++ + FQ+AL K WPLYLSTKNTILK+
Sbjct: 167 YLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKK 218
Score = 83.4 bits (197), Expect = 8e-16
Identities = 40/65 (61%), Positives = 50/65 (76%), Gaps = 2/65 (3%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTE-RRVLYDFKT-PGVAMGMYNTDESIRSF 683
HA+GDQY+A DFVVP PGKVE+ YT DGT + ++++F+ GVAMGMYN D+SI F
Sbjct: 133 HAYGDQYRATDFVVPGPGKVEMTYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDF 192
Query: 684 AHSSF 698
AHSSF
Sbjct: 193 AHSSF 197
Score = 58.4 bits (135), Expect = 3e-08
Identities = 25/42 (59%), Positives = 33/42 (78%)
Frame = +2
Query: 128 VAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGL 253
++ VVEM GDEMTRI+W IKE+LIFPYV++D +DLG+
Sbjct: 5 ISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGI 46
>BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenase 1
(NADP+), soluble protein.
Length = 414
Score = 171 bits (415), Expect = 3e-42
Identities = 89/172 (51%), Positives = 110/172 (63%), Gaps = 3/172 (1%)
Frame = +1
Query: 256 HRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTV 435
+RDAT+DQVT D+A AI KHNVG+KCATITPDE+RVEEFKLK+MW SPNGTIRNILGGTV
Sbjct: 48 NRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTV 107
Query: 436 FREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRKILLYRNPERLNLFTLHEMVRQRGVY 615
FRE I+C++IPR+V GW KPI+IG R + P ++ + T + V
Sbjct: 108 FREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEI-TYTPSDGTQKVT 166
Query: 616 YMILKLR---ALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILKR 762
Y++ + FQ+AL K WPLYLSTKNTILK+
Sbjct: 167 YLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKK 218
Score = 83.4 bits (197), Expect = 8e-16
Identities = 40/65 (61%), Positives = 50/65 (76%), Gaps = 2/65 (3%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTE-RRVLYDFKT-PGVAMGMYNTDESIRSF 683
HA+GDQY+A DFVVP PGKVE+ YT DGT + ++++F+ GVAMGMYN D+SI F
Sbjct: 133 HAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDF 192
Query: 684 AHSSF 698
AHSSF
Sbjct: 193 AHSSF 197
Score = 58.4 bits (135), Expect = 3e-08
Identities = 25/42 (59%), Positives = 33/42 (78%)
Frame = +2
Query: 128 VAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGL 253
++ VVEM GDEMTRI+W IKE+LIFPYV++D +DLG+
Sbjct: 5 ISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGI 46
>BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein.
Length = 414
Score = 171 bits (415), Expect = 3e-42
Identities = 89/172 (51%), Positives = 110/172 (63%), Gaps = 3/172 (1%)
Frame = +1
Query: 256 HRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTV 435
+RDAT+DQVT D+A AI KHNVG+KCATITPDE+RVEEFKLK+MW SPNGTIRNILGGTV
Sbjct: 48 NRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTV 107
Query: 436 FREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRKILLYRNPERLNLFTLHEMVRQRGVY 615
FRE I+C++IPR+V GW KPI+IG R + P ++ + T + V
Sbjct: 108 FREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEI-TYTPSDGTQKVT 166
Query: 616 YMILKLR---ALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILKR 762
Y++ + FQ+AL K WPLYLSTKNTILK+
Sbjct: 167 YLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKK 218
Score = 83.4 bits (197), Expect = 8e-16
Identities = 40/65 (61%), Positives = 50/65 (76%), Gaps = 2/65 (3%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTE-RRVLYDFKT-PGVAMGMYNTDESIRSF 683
HA+GDQY+A DFVVP PGKVE+ YT DGT + ++++F+ GVAMGMYN D+SI F
Sbjct: 133 HAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDF 192
Query: 684 AHSSF 698
AHSSF
Sbjct: 193 AHSSF 197
Score = 58.4 bits (135), Expect = 3e-08
Identities = 25/42 (59%), Positives = 33/42 (78%)
Frame = +2
Query: 128 VAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGL 253
++ VVEM GDEMTRI+W IKE+LIFPYV++D +DLG+
Sbjct: 5 ISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGI 46
>AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 171 bits (415), Expect = 3e-42
Identities = 89/172 (51%), Positives = 110/172 (63%), Gaps = 3/172 (1%)
Frame = +1
Query: 256 HRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTV 435
+RDAT+DQVT D+A AI KHNVG+KCATITPDE+RVEEFKLK+MW SPNGTIRNILGGTV
Sbjct: 48 NRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTV 107
Query: 436 FREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRKILLYRNPERLNLFTLHEMVRQRGVY 615
FRE I+C++IPR+V GW KPI+IG R + P ++ + T + V
Sbjct: 108 FREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEI-TYTPSDGTQKVT 166
Query: 616 YMILKLR---ALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILKR 762
Y++ + FQ+AL K WPLYLSTKNTILK+
Sbjct: 167 YLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKK 218
Score = 83.4 bits (197), Expect = 8e-16
Identities = 40/65 (61%), Positives = 50/65 (76%), Gaps = 2/65 (3%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTE-RRVLYDFKT-PGVAMGMYNTDESIRSF 683
HA+GDQY+A DFVVP PGKVE+ YT DGT + ++++F+ GVAMGMYN D+SI F
Sbjct: 133 HAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDF 192
Query: 684 AHSSF 698
AHSSF
Sbjct: 193 AHSSF 197
Score = 58.4 bits (135), Expect = 3e-08
Identities = 25/42 (59%), Positives = 33/42 (78%)
Frame = +2
Query: 128 VAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGL 253
++ VVEM GDEMTRI+W IKE+LIFPYV++D +DLG+
Sbjct: 5 ISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGI 46
>AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein.
Length = 414
Score = 171 bits (415), Expect = 3e-42
Identities = 89/172 (51%), Positives = 110/172 (63%), Gaps = 3/172 (1%)
Frame = +1
Query: 256 HRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTV 435
+RDAT+DQVT D+A AI KHNVG+KCATITPDE+RVEEFKLK+MW SPNGTIRNILGGTV
Sbjct: 48 NRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTV 107
Query: 436 FREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRKILLYRNPERLNLFTLHEMVRQRGVY 615
FRE I+C++IPR+V GW KPI+IG R + P ++ + T + V
Sbjct: 108 FREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEI-TYTPSDGTQKVT 166
Query: 616 YMILKLR---ALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILKR 762
Y++ + FQ+AL K WPLYLSTKNTILK+
Sbjct: 167 YLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKK 218
Score = 83.4 bits (197), Expect = 8e-16
Identities = 40/65 (61%), Positives = 50/65 (76%), Gaps = 2/65 (3%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTE-RRVLYDFKT-PGVAMGMYNTDESIRSF 683
HA+GDQY+A DFVVP PGKVE+ YT DGT + ++++F+ GVAMGMYN D+SI F
Sbjct: 133 HAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDF 192
Query: 684 AHSSF 698
AHSSF
Sbjct: 193 AHSSF 197
Score = 58.4 bits (135), Expect = 3e-08
Identities = 25/42 (59%), Positives = 33/42 (78%)
Frame = +2
Query: 128 VAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGL 253
++ VVEM GDEMTRI+W IKE+LIFPYV++D +DLG+
Sbjct: 5 ISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGI 46
>X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase
(NADP+) protein.
Length = 452
Score = 170 bits (413), Expect = 5e-42
Identities = 96/174 (55%), Positives = 113/174 (64%), Gaps = 5/174 (2%)
Frame = +1
Query: 253 PHRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGT 432
P+RD TDDQVTIDSA A K++V +KCATITPDE RVEEFKLKKMW SPNGTIRNILGGT
Sbjct: 87 PNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGT 146
Query: 433 VFREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRK---ILLYRNPERLNLFTLHE--MV 597
VFREPI+C++IPR+VPGWTKPI IG R A + K + R +FT + V
Sbjct: 147 VFREPIICKNIPRLVPGWTKPITIG--RHAHGDQYKATDFVADRAGTFKMVFTPKDGSGV 204
Query: 598 RQRGVYYMILKLRALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILK 759
++ VY + FQ A+QKKWPLY+STKNTILK
Sbjct: 205 KEWEVYN--FPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILK 256
Score = 80.6 bits (190), Expect = 6e-15
Identities = 37/71 (52%), Positives = 48/71 (67%), Gaps = 1/71 (1%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTERR-VLYDFKTPGVAMGMYNTDESIRSFA 686
HAHGDQYKA DFV + G ++V+T +DG+ + +Y+F GV MGMYNTDESI FA
Sbjct: 173 HAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFA 232
Query: 687 HSSFSGSFTEK 719
HS F + +K
Sbjct: 233 HSCFQYAIQKK 243
Score = 70.9 bits (166), Expect = 5e-12
Identities = 32/51 (62%), Positives = 38/51 (74%)
Frame = +2
Query: 101 RNYGTAKRVVAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGL 253
R + KR+ AKPVVEMDGDEMTRI+W IKE+LI P+V + YFDLGL
Sbjct: 36 RRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGL 86
>BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein
protein.
Length = 414
Score = 170 bits (413), Expect = 5e-42
Identities = 89/172 (51%), Positives = 110/172 (63%), Gaps = 3/172 (1%)
Frame = +1
Query: 256 HRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTV 435
+RDAT+DQVT D+A AI KHNVG+KCATITPDE+RVEEFKLK+MW SPNGTIRNILGGTV
Sbjct: 48 NRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTV 107
Query: 436 FREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRKILLYRNPERLNLFTLHEMVRQRGVY 615
FRE I+C++IPR+V GW KPI+IG R + P ++ + T + V
Sbjct: 108 FREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEI-TYTPSDGTQKVT 166
Query: 616 YMILKLR---ALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILKR 762
Y++ + FQ+AL K WPLYLSTKNTILK+
Sbjct: 167 YLVHNSEGGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKK 218
Score = 81.0 bits (191), Expect = 4e-15
Identities = 40/65 (61%), Positives = 45/65 (69%), Gaps = 2/65 (3%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTERRVLYDFKT--PGVAMGMYNTDESIRSF 683
HA+GDQY+A DFVVP PGKVE+ YT DGT + L GVAMGMYN D+SI F
Sbjct: 133 HAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNSEGGGGVAMGMYNQDKSIEDF 192
Query: 684 AHSSF 698
AHSSF
Sbjct: 193 AHSSF 197
Score = 58.4 bits (135), Expect = 3e-08
Identities = 25/42 (59%), Positives = 33/42 (78%)
Frame = +2
Query: 128 VAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGL 253
++ VVEM GDEMTRI+W IKE+LIFPYV++D +DLG+
Sbjct: 5 ISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGI 46
>BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 170 bits (413), Expect = 5e-42
Identities = 96/174 (55%), Positives = 113/174 (64%), Gaps = 5/174 (2%)
Frame = +1
Query: 253 PHRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGT 432
P+RD TDDQVTIDSA A K++V +KCATITPDE RVEEFKLKKMW SPNGTIRNILGGT
Sbjct: 87 PNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGT 146
Query: 433 VFREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRK---ILLYRNPERLNLFTLHE--MV 597
VFREPI+C++IPR+VPGWTKPI IG R A + K + R +FT + V
Sbjct: 147 VFREPIICKNIPRLVPGWTKPITIG--RHAHGDQYKATDFVADRAGTFKMVFTPKDGSGV 204
Query: 598 RQRGVYYMILKLRALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILK 759
++ VY + FQ A+QKKWPLY+STKNTILK
Sbjct: 205 KEWEVYN--FPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILK 256
Score = 80.6 bits (190), Expect = 6e-15
Identities = 37/71 (52%), Positives = 48/71 (67%), Gaps = 1/71 (1%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTERR-VLYDFKTPGVAMGMYNTDESIRSFA 686
HAHGDQYKA DFV + G ++V+T +DG+ + +Y+F GV MGMYNTDESI FA
Sbjct: 173 HAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFA 232
Query: 687 HSSFSGSFTEK 719
HS F + +K
Sbjct: 233 HSCFQYAIQKK 243
Score = 70.9 bits (166), Expect = 5e-12
Identities = 32/51 (62%), Positives = 38/51 (74%)
Frame = +2
Query: 101 RNYGTAKRVVAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGL 253
R + KR+ AKPVVEMDGDEMTRI+W IKE+LI P+V + YFDLGL
Sbjct: 36 RRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGL 86
>BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 170 bits (413), Expect = 5e-42
Identities = 96/174 (55%), Positives = 113/174 (64%), Gaps = 5/174 (2%)
Frame = +1
Query: 253 PHRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGT 432
P+RD TDDQVTIDSA A K++V +KCATITPDE RVEEFKLKKMW SPNGTIRNILGGT
Sbjct: 87 PNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGT 146
Query: 433 VFREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRK---ILLYRNPERLNLFTLHE--MV 597
VFREPI+C++IPR+VPGWTKPI IG R A + K + R +FT + V
Sbjct: 147 VFREPIICKNIPRLVPGWTKPITIG--RHAHGDQYKATDFVADRAGTFKMVFTPKDGSGV 204
Query: 598 RQRGVYYMILKLRALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILK 759
++ VY + FQ A+QKKWPLY+STKNTILK
Sbjct: 205 KEWEVYN--FPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILK 256
Score = 80.6 bits (190), Expect = 6e-15
Identities = 37/71 (52%), Positives = 48/71 (67%), Gaps = 1/71 (1%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTERR-VLYDFKTPGVAMGMYNTDESIRSFA 686
HAHGDQYKA DFV + G ++V+T +DG+ + +Y+F GV MGMYNTDESI FA
Sbjct: 173 HAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFA 232
Query: 687 HSSFSGSFTEK 719
HS F + +K
Sbjct: 233 HSCFQYAIQKK 243
Score = 70.9 bits (166), Expect = 5e-12
Identities = 32/51 (62%), Positives = 38/51 (74%)
Frame = +2
Query: 101 RNYGTAKRVVAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGL 253
R + KR+ AKPVVEMDGDEMTRI+W IKE+LI P+V + YFDLGL
Sbjct: 36 RRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGL 86
>AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial precursor variant protein.
Length = 452
Score = 170 bits (413), Expect = 5e-42
Identities = 96/174 (55%), Positives = 113/174 (64%), Gaps = 5/174 (2%)
Frame = +1
Query: 253 PHRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGT 432
P+RD TDDQVTIDSA A K++V +KCATITPDE RVEEFKLKKMW SPNGTIRNILGGT
Sbjct: 87 PNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGT 146
Query: 433 VFREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRK---ILLYRNPERLNLFTLHE--MV 597
VFREPI+C++IPR+VPGWTKPI IG R A + K + R +FT + V
Sbjct: 147 VFREPIICKNIPRLVPGWTKPITIG--RHAHGDQYKATDFVADRAGTFKMVFTPKDGSGV 204
Query: 598 RQRGVYYMILKLRALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILK 759
++ VY + FQ A+QKKWPLY+STKNTILK
Sbjct: 205 KEWEVYN--FPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILK 256
Score = 80.6 bits (190), Expect = 6e-15
Identities = 37/71 (52%), Positives = 48/71 (67%), Gaps = 1/71 (1%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTERR-VLYDFKTPGVAMGMYNTDESIRSFA 686
HAHGDQYKA DFV + G ++V+T +DG+ + +Y+F GV MGMYNTDESI FA
Sbjct: 173 HAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFA 232
Query: 687 HSSFSGSFTEK 719
HS F + +K
Sbjct: 233 HSCFQYAIQKK 243
Score = 70.9 bits (166), Expect = 5e-12
Identities = 32/51 (62%), Positives = 38/51 (74%)
Frame = +2
Query: 101 RNYGTAKRVVAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGL 253
R + KR+ AKPVVEMDGDEMTRI+W IKE+LI P+V + YFDLGL
Sbjct: 36 RRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGL 86
>AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 170 bits (413), Expect = 5e-42
Identities = 89/171 (52%), Positives = 109/171 (63%), Gaps = 3/171 (1%)
Frame = +1
Query: 256 HRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTV 435
+RDAT+DQVT D+A AI KHNVG+KCATITPDE+RVEEFKLK+MW SPNGTIRNILGGTV
Sbjct: 48 NRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTV 107
Query: 436 FREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRKILLYRNPERLNLFTLHEMVRQRGVY 615
FRE I+C++IPR+V GW KPI+IG R + P ++ + T + V
Sbjct: 108 FREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEI-TYTPSDGTQKVT 166
Query: 616 YMILKLR---ALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILK 759
Y++ + FQ+AL K WPLYLSTKNTILK
Sbjct: 167 YLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILK 217
Score = 83.4 bits (197), Expect = 8e-16
Identities = 40/65 (61%), Positives = 50/65 (76%), Gaps = 2/65 (3%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTE-RRVLYDFKT-PGVAMGMYNTDESIRSF 683
HA+GDQY+A DFVVP PGKVE+ YT DGT + ++++F+ GVAMGMYN D+SI F
Sbjct: 133 HAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDF 192
Query: 684 AHSSF 698
AHSSF
Sbjct: 193 AHSSF 197
Score = 58.4 bits (135), Expect = 3e-08
Identities = 25/42 (59%), Positives = 33/42 (78%)
Frame = +2
Query: 128 VAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGL 253
++ VVEM GDEMTRI+W IKE+LIFPYV++D +DLG+
Sbjct: 5 ISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGI 46
>CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 169 bits (411), Expect = 9e-42
Identities = 88/172 (51%), Positives = 110/172 (63%), Gaps = 3/172 (1%)
Frame = +1
Query: 256 HRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTV 435
+RDAT+DQVT D+A AI KHNVG+KCATITPDE+RVEEFKLK+MW SPNGTIRNILGGTV
Sbjct: 48 NRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTV 107
Query: 436 FREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRKILLYRNPERLNLFTLHEMVRQRGVY 615
FRE I+C++IPR+V GW +PI+IG R + P ++ + T + V
Sbjct: 108 FREAIICKNIPRLVSGWVEPIIIGRHAYGDQYRATDFVVPGPGKVEI-TYTPSDGTQKVT 166
Query: 616 YMILKLR---ALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILKR 762
Y++ + FQ+AL K WPLYLSTKNTILK+
Sbjct: 167 YLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKK 218
Score = 84.6 bits (200), Expect = 3e-16
Identities = 42/75 (56%), Positives = 54/75 (72%), Gaps = 2/75 (2%)
Frame = +3
Query: 480 WLDETYCDRPHAHGDQYKAQDFVVPKPGKVELVYTTRDGTTE-RRVLYDFKT-PGVAMGM 653
W++ R HA+GDQY+A DFVVP PGKVE+ YT DGT + ++++F+ GVAMGM
Sbjct: 124 WVEPIIIGR-HAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGM 182
Query: 654 YNTDESIRSFAHSSF 698
YN D+SI FAHSSF
Sbjct: 183 YNQDKSIEDFAHSSF 197
Score = 56.0 bits (129), Expect = 1e-07
Identities = 24/42 (57%), Positives = 32/42 (76%)
Frame = +2
Query: 128 VAAKPVVEMDGDEMTRIMWAKIKERLIFPYVKVDCLYFDLGL 253
++ VVEM GDEMTRI+W IKE+LI PYV++D +DLG+
Sbjct: 5 ISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGI 46
>U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase
protein.
Length = 419
Score = 167 bits (406), Expect = 4e-41
Identities = 95/174 (54%), Positives = 112/174 (64%), Gaps = 5/174 (2%)
Frame = +1
Query: 253 PHRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGT 432
P+RD TDDQVTIDSA A K++V +KCATITPDE RVEEFKLKKMW SPNGTIRNI GGT
Sbjct: 54 PNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNIHGGT 113
Query: 433 VFREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRK---ILLYRNPERLNLFTLHE--MV 597
VFREPI+C++IPR+VPGWTKPI IG R A + K + R +FT + V
Sbjct: 114 VFREPIICKNIPRLVPGWTKPITIG--RHAHGDQYKATDFVADRAGTFKMVFTPKDGSGV 171
Query: 598 RQRGVYYMILKLRALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILK 759
++ VY + FQ A+QKKWPLY+STKNTILK
Sbjct: 172 KEWEVYN--FPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILK 223
Score = 80.6 bits (190), Expect = 6e-15
Identities = 37/71 (52%), Positives = 48/71 (67%), Gaps = 1/71 (1%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTERR-VLYDFKTPGVAMGMYNTDESIRSFA 686
HAHGDQYKA DFV + G ++V+T +DG+ + +Y+F GV MGMYNTDESI FA
Sbjct: 140 HAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFA 199
Query: 687 HSSFSGSFTEK 719
HS F + +K
Sbjct: 200 HSCFQYAIQKK 210
>U62389-1|AAB17375.1| 154|Homo sapiens putative cytosolic
NADP-dependent isocitrate dehydrogenase protein.
Length = 154
Score = 83.4 bits (197), Expect = 8e-16
Identities = 40/65 (61%), Positives = 50/65 (76%), Gaps = 2/65 (3%)
Frame = +3
Query: 510 HAHGDQYKAQDFVVPKPGKVELVYTTRDGTTE-RRVLYDFKT-PGVAMGMYNTDESIRSF 683
HA+GDQY+A DFVVP PGKVE+ YT DGT + ++++F+ GVAMGMYN D+SI F
Sbjct: 34 HAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDF 93
Query: 684 AHSSF 698
AHSSF
Sbjct: 94 AHSSF 98
Score = 78.2 bits (184), Expect = 3e-14
Identities = 46/120 (38%), Positives = 61/120 (50%), Gaps = 3/120 (2%)
Frame = +1
Query: 412 RNILGGTVFREPILCQSIPRVVPGWTKPIVIGLMRTATNTRRKILLYRNPERLNLFTLHE 591
RNILGGTVF E I+C++IPR+V GW KPI+IG R + P ++ + T
Sbjct: 1 RNILGGTVFXEAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEI-TYTP 59
Query: 592 MVRQRGVYYMILKLR---ALLWACTIPTNRFGPLPIPVFQVALQKKWPLYLSTKNTILKR 762
+ V Y++ + FQ+AL K WPLYLSTKNTILK+
Sbjct: 60 SDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKK 119
>AK128134-1|BAC87289.1| 377|Homo sapiens member 6 (SLC12A6).
protein.
Length = 377
Score = 30.3 bits (65), Expect = 7.9
Identities = 21/76 (27%), Positives = 32/76 (42%), Gaps = 7/76 (9%)
Frame = -2
Query: 362 TLCSSGVIVAHLMPTLCFRMACAESMVT*SSVASRCGGPSQSKDNPP*HMEI-------S 204
TL + ++ H++ C A A + S C P++ P H+ I +
Sbjct: 16 TLTRTMYLITHMLSHTCTHNARAHRLTPTCSHTCLCNAPTRQIAPTPTHLHIHTHICPHT 75
Query: 203 VSL*S*PT*CVSSHHH 156
+SL PT C SSH H
Sbjct: 76 LSLSHTPTQCTSSHSH 91
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 119,439,429
Number of Sequences: 237096
Number of extensions: 2573910
Number of successful extensions: 5437
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 5230
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5421
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 9255747988
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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