Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= wdS20135
(664 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein. 91 2e-18
M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein. 91 2e-18
M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein. 91 2e-18
CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein. 91 2e-18
BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal ... 91 2e-18
BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal ... 91 2e-18
BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein. 91 2e-18
BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic pepti... 80 8e-15
AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4 pro... 79 1e-14
AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor prot... 79 1e-14
AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein. 79 1e-14
BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein. 77 6e-14
AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3 pro... 77 6e-14
M26901-1|AAA60364.1| 403|Homo sapiens renin protein. 76 1e-13
M10152-1|AAD03461.1| 406|Homo sapiens renin protein. 76 1e-13
L00073-1|AAA60363.1| 406|Homo sapiens renin protein. 76 1e-13
CR536498-1|CAG38737.1| 406|Homo sapiens REN protein. 76 1e-13
BC047752-1|AAH47752.1| 406|Homo sapiens renin protein. 76 1e-13
BC033474-1|AAH33474.1| 406|Homo sapiens renin protein. 76 1e-13
AY436324-1|AAR03502.1| 403|Homo sapiens renin protein. 76 1e-13
AL592146-1|CAI16594.1| 406|Homo sapiens renin protein. 76 1e-13
AL592114-1|CAH71224.1| 406|Homo sapiens renin protein. 76 1e-13
J00287-1|AAA98529.1| 388|Homo sapiens PEP protein. 74 4e-13
BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I (... 74 4e-13
U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein. 74 5e-13
M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein. 74 5e-13
M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein. 74 5e-13
M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein. 74 5e-13
J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein. 74 5e-13
J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein. 74 5e-13
BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein. 74 5e-13
BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein. 74 5e-13
BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinog... 74 5e-13
BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein. 74 5e-13
AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinog... 74 5e-13
AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein. 74 5e-13
AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternativ... 74 5e-13
M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein. 73 1e-12
BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein. 60 7e-09
X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mR... 54 3e-07
AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinog... 39 0.018
BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving ... 35 0.23
AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein. 35 0.23
AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein. 35 0.23
AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic ... 35 0.23
AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1 pro... 35 0.23
AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein. 35 0.23
AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein. 35 0.23
AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein. 35 0.23
AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein. 35 0.23
AF141344-1|AAG49447.1| 119|Homo sapiens LYST-interacting protei... 35 0.23
AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease ... 35 0.23
AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein. 35 0.23
DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving ... 35 0.30
BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving ... 35 0.30
BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving ... 35 0.30
AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving ... 35 0.30
AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving ... 35 0.30
AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic ... 35 0.30
AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase prot... 35 0.30
AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2 pro... 35 0.30
AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein. 35 0.30
AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving ... 35 0.30
AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving ... 35 0.30
AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving ... 35 0.30
AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving ... 35 0.30
AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving ... 35 0.30
AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein. 35 0.30
AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving ... 33 0.69
AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens ... 33 0.69
AC004144-1|AAC27979.1| 1007|Homo sapiens R34001_1 protein. 33 0.91
AK055141-1|BAB70862.1| 260|Homo sapiens protein ( Homo sapiens ... 32 2.1
BC133035-1|AAI33036.1| 129|Homo sapiens keratin associated prot... 31 4.9
BC130399-1|AAI30400.1| 129|Homo sapiens keratin associated prot... 31 4.9
BC030606-1|AAH30606.2| 514|Homo sapiens coiled-coil domain cont... 31 4.9
AB126075-1|BAD20202.1| 129|Homo sapiens keratin associated prot... 31 4.9
AK075015-1|BAC11354.1| 397|Homo sapiens protein ( Homo sapiens ... 24 8.3
>X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 91.5 bits (217), Expect = 2e-18
Identities = 52/95 (54%), Positives = 59/95 (62%), Gaps = 11/95 (11%)
Frame = +2
Query: 248 ADPSSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEPLS 394
A P+S AL R+PLH+ + R EVG +E L K V+ GP PE L
Sbjct: 15 AAPAS--ALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLK 72
Query: 395 NYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPS 499
NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS
Sbjct: 73 NYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPS 107
Score = 66.9 bits (156), Expect = 6e-11
Identities = 30/45 (66%), Positives = 36/45 (80%)
Frame = +1
Query: 517 NIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+IAC +H+KY+S KS TYV NGT F I YGSGSLSG+LS D V+V
Sbjct: 114 DIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
>M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 91.5 bits (217), Expect = 2e-18
Identities = 52/95 (54%), Positives = 59/95 (62%), Gaps = 11/95 (11%)
Frame = +2
Query: 248 ADPSSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEPLS 394
A P+S AL R+PLH+ + R EVG +E L K V+ GP PE L
Sbjct: 15 AAPAS--ALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLK 72
Query: 395 NYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPS 499
NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS
Sbjct: 73 NYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPS 107
Score = 66.9 bits (156), Expect = 6e-11
Identities = 30/45 (66%), Positives = 36/45 (80%)
Frame = +1
Query: 517 NIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+IAC +H+KY+S KS TYV NGT F I YGSGSLSG+LS D V+V
Sbjct: 114 DIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
>M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 91.5 bits (217), Expect = 2e-18
Identities = 52/95 (54%), Positives = 59/95 (62%), Gaps = 11/95 (11%)
Frame = +2
Query: 248 ADPSSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEPLS 394
A P+S AL R+PLH+ + R EVG +E L K V+ GP PE L
Sbjct: 15 AAPAS--ALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLK 72
Query: 395 NYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPS 499
NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS
Sbjct: 73 NYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPS 107
Score = 66.9 bits (156), Expect = 6e-11
Identities = 30/45 (66%), Positives = 36/45 (80%)
Frame = +1
Query: 517 NIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+IAC +H+KY+S KS TYV NGT F I YGSGSLSG+LS D V+V
Sbjct: 114 DIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
>CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 91.5 bits (217), Expect = 2e-18
Identities = 52/95 (54%), Positives = 59/95 (62%), Gaps = 11/95 (11%)
Frame = +2
Query: 248 ADPSSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEPLS 394
A P+S AL R+PLH+ + R EVG +E L K V+ GP PE L
Sbjct: 15 AAPAS--ALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLK 72
Query: 395 NYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPS 499
NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS
Sbjct: 73 NYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPS 107
Score = 66.9 bits (156), Expect = 6e-11
Identities = 30/45 (66%), Positives = 36/45 (80%)
Frame = +1
Query: 517 NIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+IAC +H+KY+S KS TYV NGT F I YGSGSLSG+LS D V+V
Sbjct: 114 DIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
>BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 91.5 bits (217), Expect = 2e-18
Identities = 52/95 (54%), Positives = 59/95 (62%), Gaps = 11/95 (11%)
Frame = +2
Query: 248 ADPSSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEPLS 394
A P+S AL R+PLH+ + R EVG +E L K V+ GP PE L
Sbjct: 15 AAPAS--ALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLK 72
Query: 395 NYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPS 499
NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS
Sbjct: 73 NYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPS 107
Score = 66.9 bits (156), Expect = 6e-11
Identities = 30/45 (66%), Positives = 36/45 (80%)
Frame = +1
Query: 517 NIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+IAC +H+KY+S KS TYV NGT F I YGSGSLSG+LS D V+V
Sbjct: 114 DIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
>BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 91.5 bits (217), Expect = 2e-18
Identities = 52/95 (54%), Positives = 59/95 (62%), Gaps = 11/95 (11%)
Frame = +2
Query: 248 ADPSSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEPLS 394
A P+S AL R+PLH+ + R EVG +E L K V+ GP PE L
Sbjct: 15 AAPAS--ALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLK 72
Query: 395 NYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPS 499
NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS
Sbjct: 73 NYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPS 107
Score = 66.9 bits (156), Expect = 6e-11
Identities = 30/45 (66%), Positives = 36/45 (80%)
Frame = +1
Query: 517 NIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+IAC +H+KY+S KS TYV NGT F I YGSGSLSG+LS D V+V
Sbjct: 114 DIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
>BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 91.5 bits (217), Expect = 2e-18
Identities = 52/95 (54%), Positives = 59/95 (62%), Gaps = 11/95 (11%)
Frame = +2
Query: 248 ADPSSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEPLS 394
A P+S AL R+PLH+ + R EVG +E L K V+ GP PE L
Sbjct: 15 AAPAS--ALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLK 72
Query: 395 NYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPS 499
NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS
Sbjct: 73 NYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPS 107
Score = 66.9 bits (156), Expect = 6e-11
Identities = 30/45 (66%), Positives = 36/45 (80%)
Frame = +1
Query: 517 NIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+IAC +H+KY+S KS TYV NGT F I YGSGSLSG+LS D V+V
Sbjct: 114 DIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSV 158
>BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic
peptidase protein.
Length = 420
Score = 79.8 bits (188), Expect = 8e-15
Identities = 43/90 (47%), Positives = 55/90 (61%), Gaps = 5/90 (5%)
Frame = +2
Query: 251 DPSSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 415
+PS L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 20 EPSGA-TLIRIPLHRVQPGRRTLNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 416 YGVISIGTPPQSFKVVFDTGSSNLWVPSKK 505
+G I +GTPPQ+F V FDTGSSNLWVPS++
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRR 108
Score = 67.7 bits (158), Expect = 3e-11
Identities = 25/55 (45%), Positives = 42/55 (76%)
Frame = +1
Query: 499 QKVHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLK 663
++ H+ ++ C LH+++D + S ++ ANGT+FAIQYG+G + G LS D +T+GG+K
Sbjct: 107 RRCHFFSVPCWLHHRFDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIK 161
>AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4
protein.
Length = 420
Score = 79.4 bits (187), Expect = 1e-14
Identities = 43/90 (47%), Positives = 55/90 (61%), Gaps = 5/90 (5%)
Frame = +2
Query: 251 DPSSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 415
+PS L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 20 EPSGA-TLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 416 YGVISIGTPPQSFKVVFDTGSSNLWVPSKK 505
+G I +GTPPQ+F V FDTGSSNLWVPS++
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRR 108
Score = 67.7 bits (158), Expect = 3e-11
Identities = 25/55 (45%), Positives = 42/55 (76%)
Frame = +1
Query: 499 QKVHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLK 663
++ H+ ++ C LH+++D + S ++ ANGT+FAIQYG+G + G LS D +T+GG+K
Sbjct: 107 RRCHFFSVPCWLHHRFDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIK 161
>AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor
protein.
Length = 420
Score = 79.4 bits (187), Expect = 1e-14
Identities = 43/90 (47%), Positives = 55/90 (61%), Gaps = 5/90 (5%)
Frame = +2
Query: 251 DPSSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 415
+PS L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 20 EPSGA-TLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 416 YGVISIGTPPQSFKVVFDTGSSNLWVPSKK 505
+G I +GTPPQ+F V FDTGSSNLWVPS++
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRR 108
Score = 67.7 bits (158), Expect = 3e-11
Identities = 25/55 (45%), Positives = 42/55 (76%)
Frame = +1
Query: 499 QKVHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLK 663
++ H+ ++ C LH+++D + S ++ ANGT+FAIQYG+G + G LS D +T+GG+K
Sbjct: 107 RRCHFFSVPCWLHHRFDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIK 161
>AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein.
Length = 420
Score = 79.4 bits (187), Expect = 1e-14
Identities = 43/90 (47%), Positives = 55/90 (61%), Gaps = 5/90 (5%)
Frame = +2
Query: 251 DPSSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 415
+PS L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 20 EPSGA-TLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 416 YGVISIGTPPQSFKVVFDTGSSNLWVPSKK 505
+G I +GTPPQ+F V FDTGSSNLWVPS++
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRR 108
Score = 67.7 bits (158), Expect = 3e-11
Identities = 25/55 (45%), Positives = 42/55 (76%)
Frame = +1
Query: 499 QKVHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLK 663
++ H+ ++ C LH+++D + S ++ ANGT+FAIQYG+G + G LS D +T+GG+K
Sbjct: 107 RRCHFFSVPCWLHHRFDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIK 161
>BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein.
Length = 464
Score = 77.0 bits (181), Expect = 6e-14
Identities = 40/83 (48%), Positives = 52/83 (62%), Gaps = 5/83 (6%)
Frame = +2
Query: 272 LYRVPLHRMKTARTHFHEV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 436
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 22 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 81
Query: 437 TPPQSFKVVFDTGSSNLWVPSKK 505
TPPQ+F V FDTGSSNLWVPS++
Sbjct: 82 TPPQNFTVAFDTGSSNLWVPSRR 104
Score = 59.3 bits (137), Expect = 1e-08
Identities = 21/55 (38%), Positives = 39/55 (70%)
Frame = +1
Query: 499 QKVHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLK 663
++ H+ ++ C H++++ S ++ +GT+FAIQYG+G + G LS D +T+GG+K
Sbjct: 103 RRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGRVDGILSEDKLTIGGIK 157
>AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3
protein.
Length = 450
Score = 77.0 bits (181), Expect = 6e-14
Identities = 40/83 (48%), Positives = 52/83 (62%), Gaps = 5/83 (6%)
Frame = +2
Query: 272 LYRVPLHRMKTARTHFHEV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 436
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 26 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 85
Query: 437 TPPQSFKVVFDTGSSNLWVPSKK 505
TPPQ+F V FDTGSSNLWVPS++
Sbjct: 86 TPPQNFTVAFDTGSSNLWVPSRR 108
Score = 59.3 bits (137), Expect = 1e-08
Identities = 21/55 (38%), Positives = 39/55 (70%)
Frame = +1
Query: 499 QKVHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLK 663
++ H+ ++ C H++++ S ++ +GT+FAIQYG+G + G LS D +T+GG+K
Sbjct: 107 RRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGRVDGILSEDKLTIGGIK 161
>M26901-1|AAA60364.1| 403|Homo sapiens renin protein.
Length = 403
Score = 76.2 bits (179), Expect = 1e-13
Identities = 42/92 (45%), Positives = 53/92 (57%), Gaps = 8/92 (8%)
Frame = +2
Query: 254 PSSVMALYRVPLHRMKTARTHFHEVGTELELLR------LKYDVTGPSPEP--LSNYLDA 409
P+ R+ L RM + R E G ++ L +K G + L+NY+D
Sbjct: 25 PTDTTTFKRIFLKRMPSIRESLKERGVDMASLGPEWSQPMKRLTLGNTTSSVILTNYMDT 84
Query: 410 QYYGVISIGTPPQSFKVVFDTGSSNLWVPSKK 505
QYYG I IGTPPQ+FKVVFDTGSSN+WVPS K
Sbjct: 85 QYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSK 116
Score = 54.4 bits (125), Expect = 3e-07
Identities = 21/46 (45%), Positives = 33/46 (71%)
Frame = +1
Query: 523 ACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG+
Sbjct: 123 ACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGI 168
>M10152-1|AAD03461.1| 406|Homo sapiens renin protein.
Length = 406
Score = 76.2 bits (179), Expect = 1e-13
Identities = 42/92 (45%), Positives = 53/92 (57%), Gaps = 8/92 (8%)
Frame = +2
Query: 254 PSSVMALYRVPLHRMKTARTHFHEVGTELELLR------LKYDVTGPSPEP--LSNYLDA 409
P+ R+ L RM + R E G ++ L +K G + L+NY+D
Sbjct: 25 PTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDT 84
Query: 410 QYYGVISIGTPPQSFKVVFDTGSSNLWVPSKK 505
QYYG I IGTPPQ+FKVVFDTGSSN+WVPS K
Sbjct: 85 QYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSK 116
Score = 54.4 bits (125), Expect = 3e-07
Identities = 21/46 (45%), Positives = 33/46 (71%)
Frame = +1
Query: 523 ACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG+
Sbjct: 123 ACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGI 168
>L00073-1|AAA60363.1| 406|Homo sapiens renin protein.
Length = 406
Score = 76.2 bits (179), Expect = 1e-13
Identities = 42/92 (45%), Positives = 53/92 (57%), Gaps = 8/92 (8%)
Frame = +2
Query: 254 PSSVMALYRVPLHRMKTARTHFHEVGTELELLR------LKYDVTGPSPEP--LSNYLDA 409
P+ R+ L RM + R E G ++ L +K G + L+NY+D
Sbjct: 25 PTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDT 84
Query: 410 QYYGVISIGTPPQSFKVVFDTGSSNLWVPSKK 505
QYYG I IGTPPQ+FKVVFDTGSSN+WVPS K
Sbjct: 85 QYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSK 116
Score = 54.4 bits (125), Expect = 3e-07
Identities = 21/46 (45%), Positives = 33/46 (71%)
Frame = +1
Query: 523 ACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG+
Sbjct: 123 ACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGI 168
>CR536498-1|CAG38737.1| 406|Homo sapiens REN protein.
Length = 406
Score = 76.2 bits (179), Expect = 1e-13
Identities = 42/92 (45%), Positives = 53/92 (57%), Gaps = 8/92 (8%)
Frame = +2
Query: 254 PSSVMALYRVPLHRMKTARTHFHEVGTELELLR------LKYDVTGPSPEP--LSNYLDA 409
P+ R+ L RM + R E G ++ L +K G + L+NY+D
Sbjct: 25 PTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDT 84
Query: 410 QYYGVISIGTPPQSFKVVFDTGSSNLWVPSKK 505
QYYG I IGTPPQ+FKVVFDTGSSN+WVPS K
Sbjct: 85 QYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSK 116
Score = 54.4 bits (125), Expect = 3e-07
Identities = 21/46 (45%), Positives = 33/46 (71%)
Frame = +1
Query: 523 ACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG+
Sbjct: 123 ACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGI 168
>BC047752-1|AAH47752.1| 406|Homo sapiens renin protein.
Length = 406
Score = 76.2 bits (179), Expect = 1e-13
Identities = 42/92 (45%), Positives = 53/92 (57%), Gaps = 8/92 (8%)
Frame = +2
Query: 254 PSSVMALYRVPLHRMKTARTHFHEVGTELELLR------LKYDVTGPSPEP--LSNYLDA 409
P+ R+ L RM + R E G ++ L +K G + L+NY+D
Sbjct: 25 PTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDT 84
Query: 410 QYYGVISIGTPPQSFKVVFDTGSSNLWVPSKK 505
QYYG I IGTPPQ+FKVVFDTGSSN+WVPS K
Sbjct: 85 QYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSK 116
Score = 54.4 bits (125), Expect = 3e-07
Identities = 21/46 (45%), Positives = 33/46 (71%)
Frame = +1
Query: 523 ACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG+
Sbjct: 123 ACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGI 168
>BC033474-1|AAH33474.1| 406|Homo sapiens renin protein.
Length = 406
Score = 76.2 bits (179), Expect = 1e-13
Identities = 42/92 (45%), Positives = 53/92 (57%), Gaps = 8/92 (8%)
Frame = +2
Query: 254 PSSVMALYRVPLHRMKTARTHFHEVGTELELLR------LKYDVTGPSPEP--LSNYLDA 409
P+ R+ L RM + R E G ++ L +K G + L+NY+D
Sbjct: 25 PTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDT 84
Query: 410 QYYGVISIGTPPQSFKVVFDTGSSNLWVPSKK 505
QYYG I IGTPPQ+FKVVFDTGSSN+WVPS K
Sbjct: 85 QYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSK 116
Score = 54.4 bits (125), Expect = 3e-07
Identities = 21/46 (45%), Positives = 33/46 (71%)
Frame = +1
Query: 523 ACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG+
Sbjct: 123 ACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGI 168
>AY436324-1|AAR03502.1| 403|Homo sapiens renin protein.
Length = 403
Score = 76.2 bits (179), Expect = 1e-13
Identities = 42/92 (45%), Positives = 53/92 (57%), Gaps = 8/92 (8%)
Frame = +2
Query: 254 PSSVMALYRVPLHRMKTARTHFHEVGTELELLR------LKYDVTGPSPEP--LSNYLDA 409
P+ R+ L RM + R E G ++ L +K G + L+NY+D
Sbjct: 25 PTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDT 84
Query: 410 QYYGVISIGTPPQSFKVVFDTGSSNLWVPSKK 505
QYYG I IGTPPQ+FKVVFDTGSSN+WVPS K
Sbjct: 85 QYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSK 116
Score = 54.4 bits (125), Expect = 3e-07
Identities = 21/46 (45%), Positives = 33/46 (71%)
Frame = +1
Query: 523 ACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG+
Sbjct: 123 ACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGI 168
>AL592146-1|CAI16594.1| 406|Homo sapiens renin protein.
Length = 406
Score = 76.2 bits (179), Expect = 1e-13
Identities = 42/92 (45%), Positives = 53/92 (57%), Gaps = 8/92 (8%)
Frame = +2
Query: 254 PSSVMALYRVPLHRMKTARTHFHEVGTELELLR------LKYDVTGPSPEP--LSNYLDA 409
P+ R+ L RM + R E G ++ L +K G + L+NY+D
Sbjct: 25 PTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDT 84
Query: 410 QYYGVISIGTPPQSFKVVFDTGSSNLWVPSKK 505
QYYG I IGTPPQ+FKVVFDTGSSN+WVPS K
Sbjct: 85 QYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSK 116
Score = 54.4 bits (125), Expect = 3e-07
Identities = 21/46 (45%), Positives = 33/46 (71%)
Frame = +1
Query: 523 ACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG+
Sbjct: 123 ACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGI 168
>AL592114-1|CAH71224.1| 406|Homo sapiens renin protein.
Length = 406
Score = 76.2 bits (179), Expect = 1e-13
Identities = 42/92 (45%), Positives = 53/92 (57%), Gaps = 8/92 (8%)
Frame = +2
Query: 254 PSSVMALYRVPLHRMKTARTHFHEVGTELELLR------LKYDVTGPSPEP--LSNYLDA 409
P+ R+ L RM + R E G ++ L +K G + L+NY+D
Sbjct: 25 PTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDT 84
Query: 410 QYYGVISIGTPPQSFKVVFDTGSSNLWVPSKK 505
QYYG I IGTPPQ+FKVVFDTGSSN+WVPS K
Sbjct: 85 QYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSK 116
Score = 54.4 bits (125), Expect = 3e-07
Identities = 21/46 (45%), Positives = 33/46 (71%)
Frame = +1
Query: 523 ACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG+
Sbjct: 123 ACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGI 168
>J00287-1|AAA98529.1| 388|Homo sapiens PEP protein.
Length = 388
Score = 74.1 bits (174), Expect = 4e-13
Identities = 44/100 (44%), Positives = 54/100 (54%), Gaps = 12/100 (12%)
Frame = +2
Query: 236 IFFGADPSSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP---- 382
+ G S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 5 LLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLVD 64
Query: 383 -EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPS 499
+PL NYLD +Y+G I IGTP Q F VVFDTGSSNLWVPS
Sbjct: 65 EQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPS 104
Score = 49.2 bits (112), Expect = 1e-05
Identities = 20/52 (38%), Positives = 33/52 (63%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
V+ +++AC HN+++ S TY + +I YG+GS++G L D V VGG+
Sbjct: 105 VYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGI 156
>BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I
(pepsinogen A) protein.
Length = 388
Score = 74.1 bits (174), Expect = 4e-13
Identities = 44/100 (44%), Positives = 54/100 (54%), Gaps = 12/100 (12%)
Frame = +2
Query: 236 IFFGADPSSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP---- 382
+ G S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 5 LLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLVD 64
Query: 383 -EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPS 499
+PL NYLD +Y+G I IGTP Q F VVFDTGSSNLWVPS
Sbjct: 65 EQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPS 104
Score = 49.2 bits (112), Expect = 1e-05
Identities = 20/52 (38%), Positives = 33/52 (63%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
V+ +++AC HN+++ S TY + +I YG+GS++G L D V VGG+
Sbjct: 105 VYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGI 156
>U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein.
Length = 388
Score = 73.7 bits (173), Expect = 5e-13
Identities = 43/86 (50%), Positives = 54/86 (62%), Gaps = 9/86 (10%)
Frame = +2
Query: 269 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 421
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 422 VISIGTPPQSFKVVFDTGSSNLWVPS 499
ISIGTPPQ+F V+FDTGSSNLWVPS
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPS 101
Score = 52.8 bits (121), Expect = 1e-06
Identities = 22/53 (41%), Positives = 35/53 (66%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLK 663
V+ + AC H++++ +S TY NG F++QYGSGSL+GF D +TV ++
Sbjct: 102 VYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQ 154
>M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 73.7 bits (173), Expect = 5e-13
Identities = 40/87 (45%), Positives = 54/87 (62%), Gaps = 10/87 (11%)
Frame = +2
Query: 269 ALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSPEPLSNYLDAQYY 418
+L+RVPL R + AR+ E L +++ + + EPL NYLD +Y+
Sbjct: 20 SLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYF 79
Query: 419 GVISIGTPPQSFKVVFDTGSSNLWVPS 499
G ISIG+PPQ+F V+FDTGSSNLWVPS
Sbjct: 80 GTISIGSPPQNFTVIFDTGSSNLWVPS 106
Score = 54.4 bits (125), Expect = 3e-07
Identities = 24/52 (46%), Positives = 34/52 (65%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
V+ T+ AC H+++ +S TY G F+IQYG+GSLSG + D V+V GL
Sbjct: 107 VYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGL 158
>M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein.
Length = 388
Score = 73.7 bits (173), Expect = 5e-13
Identities = 43/86 (50%), Positives = 54/86 (62%), Gaps = 9/86 (10%)
Frame = +2
Query: 269 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 421
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 422 VISIGTPPQSFKVVFDTGSSNLWVPS 499
ISIGTPPQ+F V+FDTGSSNLWVPS
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPS 101
Score = 52.8 bits (121), Expect = 1e-06
Identities = 22/53 (41%), Positives = 35/53 (66%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLK 663
V+ + AC H++++ +S TY NG F++QYGSGSL+GF D +TV ++
Sbjct: 102 VYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQ 154
>M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein.
Length = 385
Score = 73.7 bits (173), Expect = 5e-13
Identities = 43/86 (50%), Positives = 54/86 (62%), Gaps = 9/86 (10%)
Frame = +2
Query: 269 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 421
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 14 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 72
Query: 422 VISIGTPPQSFKVVFDTGSSNLWVPS 499
ISIGTPPQ+F V+FDTGSSNLWVPS
Sbjct: 73 EISIGTPPQNFLVLFDTGSSNLWVPS 98
Score = 52.8 bits (121), Expect = 1e-06
Identities = 22/53 (41%), Positives = 35/53 (66%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLK 663
V+ + AC H++++ +S TY NG F++QYGSGSL+GF D +TV ++
Sbjct: 99 VYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQ 151
>J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein.
Length = 396
Score = 73.7 bits (173), Expect = 5e-13
Identities = 40/87 (45%), Positives = 54/87 (62%), Gaps = 10/87 (11%)
Frame = +2
Query: 269 ALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSPEPLSNYLDAQYY 418
+L+RVPL R + AR+ E L +++ + + EPL NYLD +Y+
Sbjct: 20 SLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYF 79
Query: 419 GVISIGTPPQSFKVVFDTGSSNLWVPS 499
G ISIG+PPQ+F V+FDTGSSNLWVPS
Sbjct: 80 GTISIGSPPQNFTVIFDTGSSNLWVPS 106
Score = 54.4 bits (125), Expect = 3e-07
Identities = 24/52 (46%), Positives = 34/52 (65%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
V+ T+ AC H+++ +S TY G F+IQYG+GSLSG + D V+V GL
Sbjct: 107 VYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGL 158
>J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein.
Length = 388
Score = 73.7 bits (173), Expect = 5e-13
Identities = 43/86 (50%), Positives = 54/86 (62%), Gaps = 9/86 (10%)
Frame = +2
Query: 269 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 421
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 422 VISIGTPPQSFKVVFDTGSSNLWVPS 499
ISIGTPPQ+F V+FDTGSSNLWVPS
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPS 101
Score = 52.8 bits (121), Expect = 1e-06
Identities = 22/53 (41%), Positives = 35/53 (66%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLK 663
V+ + AC H++++ +S TY NG F++QYGSGSL+GF D +TV ++
Sbjct: 102 VYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQ 154
>BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein.
Length = 363
Score = 73.7 bits (173), Expect = 5e-13
Identities = 40/87 (45%), Positives = 54/87 (62%), Gaps = 10/87 (11%)
Frame = +2
Query: 269 ALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSPEPLSNYLDAQYY 418
+L+RVPL R + AR+ E L +++ + + EPL NYLD +Y+
Sbjct: 20 SLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYF 79
Query: 419 GVISIGTPPQSFKVVFDTGSSNLWVPS 499
G ISIG+PPQ+F V+FDTGSSNLWVPS
Sbjct: 80 GTISIGSPPQNFTVIFDTGSSNLWVPS 106
Score = 54.4 bits (125), Expect = 3e-07
Identities = 24/52 (46%), Positives = 34/52 (65%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
V+ T+ AC H+++ +S TY G F+IQYG+GSLSG + D V+V GL
Sbjct: 107 VYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGL 158
>BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 73.7 bits (173), Expect = 5e-13
Identities = 40/87 (45%), Positives = 54/87 (62%), Gaps = 10/87 (11%)
Frame = +2
Query: 269 ALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSPEPLSNYLDAQYY 418
+L+RVPL R + AR+ E L +++ + + EPL NYLD +Y+
Sbjct: 20 SLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYF 79
Query: 419 GVISIGTPPQSFKVVFDTGSSNLWVPS 499
G ISIG+PPQ+F V+FDTGSSNLWVPS
Sbjct: 80 GTISIGSPPQNFTVIFDTGSSNLWVPS 106
Score = 54.4 bits (125), Expect = 3e-07
Identities = 24/52 (46%), Positives = 34/52 (65%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
V+ T+ AC H+++ +S TY G F+IQYG+GSLSG + D V+V GL
Sbjct: 107 VYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGL 158
>BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 73.7 bits (173), Expect = 5e-13
Identities = 43/86 (50%), Positives = 54/86 (62%), Gaps = 9/86 (10%)
Frame = +2
Query: 269 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 421
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 422 VISIGTPPQSFKVVFDTGSSNLWVPS 499
ISIGTPPQ+F V+FDTGSSNLWVPS
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPS 101
Score = 52.8 bits (121), Expect = 1e-06
Identities = 22/53 (41%), Positives = 35/53 (66%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLK 663
V+ + AC H++++ +S TY NG F++QYGSGSL+GF D +TV ++
Sbjct: 102 VYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQ 154
>BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 73.7 bits (173), Expect = 5e-13
Identities = 40/87 (45%), Positives = 54/87 (62%), Gaps = 10/87 (11%)
Frame = +2
Query: 269 ALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSPEPLSNYLDAQYY 418
+L+RVPL R + AR+ E L +++ + + EPL NYLD +Y+
Sbjct: 20 SLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYF 79
Query: 419 GVISIGTPPQSFKVVFDTGSSNLWVPS 499
G ISIG+PPQ+F V+FDTGSSNLWVPS
Sbjct: 80 GTISIGSPPQNFTVIFDTGSSNLWVPS 106
Score = 54.4 bits (125), Expect = 3e-07
Identities = 24/52 (46%), Positives = 34/52 (65%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
V+ T+ AC H+++ +S TY G F+IQYG+GSLSG + D V+V GL
Sbjct: 107 VYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGL 158
>AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 73.7 bits (173), Expect = 5e-13
Identities = 43/86 (50%), Positives = 54/86 (62%), Gaps = 9/86 (10%)
Frame = +2
Query: 269 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 421
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 422 VISIGTPPQSFKVVFDTGSSNLWVPS 499
ISIGTPPQ+F V+FDTGSSNLWVPS
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPS 101
Score = 52.8 bits (121), Expect = 1e-06
Identities = 22/53 (41%), Positives = 35/53 (66%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLK 663
V+ + AC H++++ +S TY NG F++QYGSGSL+GF D +TV ++
Sbjct: 102 VYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQ 154
>AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein.
Length = 396
Score = 73.7 bits (173), Expect = 5e-13
Identities = 40/87 (45%), Positives = 54/87 (62%), Gaps = 10/87 (11%)
Frame = +2
Query: 269 ALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSPEPLSNYLDAQYY 418
+L+RVPL R + AR+ E L +++ + + EPL NYLD +Y+
Sbjct: 20 SLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYF 79
Query: 419 GVISIGTPPQSFKVVFDTGSSNLWVPS 499
G ISIG+PPQ+F V+FDTGSSNLWVPS
Sbjct: 80 GTISIGSPPQNFTVIFDTGSSNLWVPS 106
Score = 54.4 bits (125), Expect = 3e-07
Identities = 24/52 (46%), Positives = 34/52 (65%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
V+ T+ AC H+++ +S TY G F+IQYG+GSLSG + D V+V GL
Sbjct: 107 VYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGL 158
>AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternative
protein.
Length = 363
Score = 73.7 bits (173), Expect = 5e-13
Identities = 40/87 (45%), Positives = 54/87 (62%), Gaps = 10/87 (11%)
Frame = +2
Query: 269 ALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSPEPLSNYLDAQYY 418
+L+RVPL R + AR+ E L +++ + + EPL NYLD +Y+
Sbjct: 20 SLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYF 79
Query: 419 GVISIGTPPQSFKVVFDTGSSNLWVPS 499
G ISIG+PPQ+F V+FDTGSSNLWVPS
Sbjct: 80 GTISIGSPPQNFTVIFDTGSSNLWVPS 106
Score = 54.4 bits (125), Expect = 3e-07
Identities = 24/52 (46%), Positives = 34/52 (65%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
V+ T+ AC H+++ +S TY G F+IQYG+GSLSG + D V+V GL
Sbjct: 107 VYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGL 158
>M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein.
Length = 388
Score = 72.5 bits (170), Expect = 1e-12
Identities = 43/100 (43%), Positives = 54/100 (54%), Gaps = 12/100 (12%)
Frame = +2
Query: 236 IFFGADPSSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP---- 382
+ G S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 5 LLLGLVALSECIMYKVPLIRKKSFRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVD 64
Query: 383 -EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPS 499
+PL NYLD +Y+G I IGTP Q F V+FDTGSSNLWVPS
Sbjct: 65 EQPLENYLDMEYFGTIGIGTPAQDFTVLFDTGSSNLWVPS 104
Score = 49.2 bits (112), Expect = 1e-05
Identities = 20/52 (38%), Positives = 33/52 (63%)
Frame = +1
Query: 505 VHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
V+ +++AC HN+++ S TY + +I YG+GS++G L D V VGG+
Sbjct: 105 VYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGI 156
>BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein.
Length = 104
Score = 60.1 bits (139), Expect = 7e-09
Identities = 38/82 (46%), Positives = 49/82 (59%), Gaps = 9/82 (10%)
Frame = +2
Query: 269 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 421
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 422 VISIGTPPQSFKVVFDTGSSNL 487
ISIGTPPQ+F V+FDTGSS L
Sbjct: 76 EISIGTPPQNFLVLFDTGSSPL 97
>X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mRNA
fragment for renin (aa 105-401). ).
Length = 300
Score = 54.4 bits (125), Expect = 3e-07
Identities = 21/46 (45%), Positives = 33/46 (71%)
Frame = +1
Query: 523 ACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGL 660
AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG+
Sbjct: 16 ACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGI 61
>AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 86
Score = 38.7 bits (86), Expect = 0.018
Identities = 28/70 (40%), Positives = 37/70 (52%), Gaps = 9/70 (12%)
Frame = +2
Query: 260 SVMALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQ 412
+V+ RVPL + K+ R E G E LR KYD + EP++ Y+DA
Sbjct: 18 AVICKQRVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAA 76
Query: 413 YYGVISIGTP 442
Y+G ISIGTP
Sbjct: 77 YFGEISIGTP 86
>BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving
enzyme 2 protein.
Length = 518
Score = 35.1 bits (77), Expect = 0.23
Identities = 15/27 (55%), Positives = 19/27 (70%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY + IGTPPQ +++ DTGSSN V
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV 118
Score = 33.5 bits (73), Expect = 0.69
Identities = 13/36 (36%), Positives = 22/36 (61%)
Frame = +1
Query: 544 YDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+D+ +S TY + G ++Y GS +GF+ D VT+
Sbjct: 130 FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTI 165
>AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein.
Length = 518
Score = 35.1 bits (77), Expect = 0.23
Identities = 15/27 (55%), Positives = 19/27 (70%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY + IGTPPQ +++ DTGSSN V
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV 118
Score = 33.5 bits (73), Expect = 0.69
Identities = 13/36 (36%), Positives = 22/36 (61%)
Frame = +1
Query: 544 YDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+D+ +S TY + G ++Y GS +GF+ D VT+
Sbjct: 130 FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTI 165
>AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein.
Length = 439
Score = 35.1 bits (77), Expect = 0.23
Identities = 15/27 (55%), Positives = 19/27 (70%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY + IGTPPQ +++ DTGSSN V
Sbjct: 13 YYLEMLIGTPPQKLQILVDTGSSNFAV 39
Score = 33.5 bits (73), Expect = 0.69
Identities = 13/36 (36%), Positives = 22/36 (61%)
Frame = +1
Query: 544 YDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+D+ +S TY + G ++Y GS +GF+ D VT+
Sbjct: 51 FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTI 86
>AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic
proteinase Asp 1 protein.
Length = 518
Score = 35.1 bits (77), Expect = 0.23
Identities = 15/27 (55%), Positives = 19/27 (70%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY + IGTPPQ +++ DTGSSN V
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV 118
Score = 33.5 bits (73), Expect = 0.69
Identities = 13/36 (36%), Positives = 22/36 (61%)
Frame = +1
Query: 544 YDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+D+ +S TY + G ++Y GS +GF+ D VT+
Sbjct: 130 FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTI 165
>AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1
protein.
Length = 518
Score = 35.1 bits (77), Expect = 0.23
Identities = 15/27 (55%), Positives = 19/27 (70%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY + IGTPPQ +++ DTGSSN V
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV 118
Score = 33.5 bits (73), Expect = 0.69
Identities = 13/36 (36%), Positives = 22/36 (61%)
Frame = +1
Query: 544 YDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+D+ +S TY + G ++Y GS +GF+ D VT+
Sbjct: 130 FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTI 165
>AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein.
Length = 518
Score = 35.1 bits (77), Expect = 0.23
Identities = 15/27 (55%), Positives = 19/27 (70%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY + IGTPPQ +++ DTGSSN V
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV 118
Score = 33.5 bits (73), Expect = 0.69
Identities = 13/36 (36%), Positives = 22/36 (61%)
Frame = +1
Query: 544 YDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+D+ +S TY + G ++Y GS +GF+ D VT+
Sbjct: 130 FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTI 165
>AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein.
Length = 396
Score = 35.1 bits (77), Expect = 0.23
Identities = 15/27 (55%), Positives = 19/27 (70%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY + IGTPPQ +++ DTGSSN V
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV 118
Score = 33.5 bits (73), Expect = 0.69
Identities = 13/36 (36%), Positives = 22/36 (61%)
Frame = +1
Query: 544 YDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+D+ +S TY + G ++Y GS +GF+ D VT+
Sbjct: 130 FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTI 165
>AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein.
Length = 468
Score = 35.1 bits (77), Expect = 0.23
Identities = 15/27 (55%), Positives = 19/27 (70%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY + IGTPPQ +++ DTGSSN V
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV 118
Score = 33.5 bits (73), Expect = 0.69
Identities = 13/36 (36%), Positives = 22/36 (61%)
Frame = +1
Query: 544 YDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+D+ +S TY + G ++Y GS +GF+ D VT+
Sbjct: 130 FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTI 165
>AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 35.1 bits (77), Expect = 0.23
Identities = 15/27 (55%), Positives = 19/27 (70%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY + IGTPPQ +++ DTGSSN V
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV 118
Score = 33.5 bits (73), Expect = 0.69
Identities = 13/36 (36%), Positives = 22/36 (61%)
Frame = +1
Query: 544 YDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+D+ +S TY + G ++Y GS +GF+ D VT+
Sbjct: 130 FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTI 165
>AF141344-1|AAG49447.1| 119|Homo sapiens LYST-interacting protein
LIP8 protein.
Length = 119
Score = 35.1 bits (77), Expect = 0.23
Identities = 18/51 (35%), Positives = 22/51 (43%), Gaps = 2/51 (3%)
Frame = -1
Query: 634 WRGSRRGCRSRTVSRTGCHSRRTSWTCGCRTCC--AANKRCWCSALFGRHP 488
W GS+R C + V + S SW CR CC + CSA R P
Sbjct: 8 WPGSKRECANCRVGTSSWRSSGWSWWKDCRPCCRPTGMRPTSCSAPLSRRP 58
>AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease
protein.
Length = 518
Score = 35.1 bits (77), Expect = 0.23
Identities = 15/27 (55%), Positives = 19/27 (70%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY + IGTPPQ +++ DTGSSN V
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV 118
Score = 33.5 bits (73), Expect = 0.69
Identities = 13/36 (36%), Positives = 22/36 (61%)
Frame = +1
Query: 544 YDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+D+ +S TY + G ++Y GS +GF+ D VT+
Sbjct: 130 FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTI 165
>AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 35.1 bits (77), Expect = 0.23
Identities = 15/27 (55%), Positives = 19/27 (70%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY + IGTPPQ +++ DTGSSN V
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV 118
Score = 33.5 bits (73), Expect = 0.69
Identities = 13/36 (36%), Positives = 22/36 (61%)
Frame = +1
Query: 544 YDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+D+ +S TY + G ++Y GS +GF+ D VT+
Sbjct: 130 FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTI 165
>DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAV 101
>BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAV 101
>BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAV 101
>AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving
enzyme type C protein.
Length = 457
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAV 101
>AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving
enzyme type B protein.
Length = 476
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAV 101
>AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic
proteinase Asp 2 protein.
Length = 501
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAV 101
>AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase
protein.
Length = 501
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAV 101
>AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2
protein.
Length = 501
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAV 101
>AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein.
Length = 488
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 62 YYVEMTVGSPPQTLNILVDTGSSNFAV 88
>AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving
enzyme protein.
Length = 501
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAV 101
>AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving
enzyme isoform I-127 protein.
Length = 127
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAV 101
>AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving
enzyme I-432 protein.
Length = 432
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAV 101
>AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving
enzyme I-457 protein.
Length = 457
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAV 101
>AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving
enzyme I-476 protein.
Length = 476
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAV 101
>AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein.
Length = 532
Score = 34.7 bits (76), Expect = 0.30
Identities = 13/27 (48%), Positives = 20/27 (74%)
Frame = +2
Query: 413 YYGVISIGTPPQSFKVVFDTGSSNLWV 493
YY +++G+PPQ+ ++ DTGSSN V
Sbjct: 106 YYVEMTVGSPPQTLNILVDTGSSNFAV 132
>AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving
enzyme 2, EC 3.4.23. protein.
Length = 415
Score = 33.5 bits (73), Expect = 0.69
Identities = 13/36 (36%), Positives = 22/36 (61%)
Frame = +1
Query: 544 YDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+D+ +S TY + G ++Y GS +GF+ D VT+
Sbjct: 27 FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTI 62
>AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens
cDNA PSEC0239 fis, clone OVARC1000363, highly similar to
Homo sapiens aspartyl protease mRNA. ).
Length = 423
Score = 33.5 bits (73), Expect = 0.69
Identities = 13/36 (36%), Positives = 22/36 (61%)
Frame = +1
Query: 544 YDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTV 651
+D+ +S TY + G ++Y GS +GF+ D VT+
Sbjct: 35 FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTI 70
Score = 32.3 bits (70), Expect = 1.6
Identities = 13/21 (61%), Positives = 16/21 (76%)
Frame = +2
Query: 431 IGTPPQSFKVVFDTGSSNLWV 493
IGTPPQ +++ DTGSSN V
Sbjct: 3 IGTPPQKLQILVDTGSSNFAV 23
>AC004144-1|AAC27979.1| 1007|Homo sapiens R34001_1 protein.
Length = 1007
Score = 33.1 bits (72), Expect = 0.91
Identities = 14/37 (37%), Positives = 16/37 (43%), Gaps = 1/37 (2%)
Frame = -1
Query: 580 HSRRTSWTCG-CRTCCAANKRCWCSALFGRHPEVGGS 473
H R T W CR C + CWC GRH G+
Sbjct: 962 HRRCTPWPAQTCRPCWNTTRSCWCRPCGGRHGGTEGA 998
>AK055141-1|BAB70862.1| 260|Homo sapiens protein ( Homo sapiens
cDNA FLJ30579 fis, clone BRAWH2006989, weakly similar to
DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT (EC
2.7.7.6). ).
Length = 260
Score = 31.9 bits (69), Expect = 2.1
Identities = 17/35 (48%), Positives = 18/35 (51%)
Frame = -1
Query: 643 HHQWRGSRRGCRSRTVSRTGCHSRRTSWTCGCRTC 539
H+ W GS R C S T S G HS SWT R C
Sbjct: 26 HNSWTGSNRACSSWTGSTRG-HS---SWTGSSRAC 56
>BC133035-1|AAI33036.1| 129|Homo sapiens keratin associated protein
5-6 protein.
Length = 129
Score = 30.7 bits (66), Expect = 4.9
Identities = 17/41 (41%), Positives = 21/41 (51%)
Frame = -1
Query: 628 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCSA 506
GS+ GC S S+ GC S CGC C K C+CS+
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCSS 98
>BC130399-1|AAI30400.1| 129|Homo sapiens keratin associated protein
5-6 protein.
Length = 129
Score = 30.7 bits (66), Expect = 4.9
Identities = 17/41 (41%), Positives = 21/41 (51%)
Frame = -1
Query: 628 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCSA 506
GS+ GC S S+ GC S CGC C K C+CS+
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCSS 98
>BC030606-1|AAH30606.2| 514|Homo sapiens coiled-coil domain
containing 11 protein.
Length = 514
Score = 30.7 bits (66), Expect = 4.9
Identities = 12/26 (46%), Positives = 18/26 (69%)
Frame = -1
Query: 478 GSGVEYHLERLRRRADTDHSVVLSIK 401
G G E+HLER+RR ++++ SIK
Sbjct: 30 GQGAEHHLERIRRSHQKHNAILASIK 55
>AB126075-1|BAD20202.1| 129|Homo sapiens keratin associated protein
protein.
Length = 129
Score = 30.7 bits (66), Expect = 4.9
Identities = 17/41 (41%), Positives = 21/41 (51%)
Frame = -1
Query: 628 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCSA 506
GS+ GC S S+ GC S CGC C K C+CS+
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCSS 98
>AK075015-1|BAC11354.1| 397|Homo sapiens protein ( Homo sapiens
cDNA FLJ90534 fis, clone OVARC1000003, highly similar to
Homo sapiens sodium dependent phosphate transporter
isoform ).
Length = 397
Score = 24.2 bits (50), Expect(2) = 8.3
Identities = 13/41 (31%), Positives = 16/41 (39%)
Frame = -1
Query: 652 PR*HHQWRGSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAA 530
P+ W S + + TGC R C CR CC A
Sbjct: 297 PKKLQNWMRSLKPWDAVVSKFTGCFQMRCC--CCCRVCCRA 335
Score = 24.2 bits (50), Expect(2) = 8.3
Identities = 7/13 (53%), Positives = 8/13 (61%)
Frame = -1
Query: 556 CGCRTCCAANKRC 518
CGC CC +K C
Sbjct: 340 CGCPKCCRCSKCC 352
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 95,332,424
Number of Sequences: 237096
Number of extensions: 2170758
Number of successful extensions: 4147
Number of sequences better than 10.0: 77
Number of HSP's better than 10.0 without gapping: 3909
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4136
length of database: 76,859,062
effective HSP length: 87
effective length of database: 56,231,710
effective search space used: 7478817430
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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