Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= wdS00372
(458 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 120 2e-26
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 109 3e-23
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 99 4e-20
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 89 3e-17
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 87 2e-16
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 87 2e-16
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 87 2e-16
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 81 9e-15
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 79 5e-14
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 78 1e-13
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 77 1e-13
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 76 3e-13
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 73 2e-12
UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8; ... 71 1e-11
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 69 4e-11
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 68 9e-11
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 68 1e-10
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 67 2e-10
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 65 6e-10
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 63 2e-09
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 58 1e-07
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 58 1e-07
UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subuni... 57 2e-07
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 56 3e-07
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 54 1e-06
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 54 1e-06
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 51 1e-05
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 50 3e-05
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 49 6e-05
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 48 7e-05
UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila melanogaster|... 48 1e-04
UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 47 2e-04
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 46 3e-04
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 46 4e-04
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 46 4e-04
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 46 5e-04
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 45 0.001
UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 45 0.001
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 44 0.001
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 42 0.005
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 42 0.005
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 42 0.006
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 42 0.008
UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependen... 41 0.015
UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1; ... 41 0.015
UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella ve... 40 0.026
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 40 0.034
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 40 0.034
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 38 0.10
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 37 0.18
UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp - Pa... 37 0.24
UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenas... 37 0.24
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 36 0.32
UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 36 0.32
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 36 0.42
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 36 0.56
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 36 0.56
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 35 0.73
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 35 0.97
UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1; V... 35 0.97
UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1; N... 35 0.97
UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2... 34 1.3
UniRef50_A3Y262 Cluster: Phosphorelay protein; n=4; Vibrionales|... 34 1.3
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 34 1.7
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 33 2.2
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 33 2.2
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 33 2.2
UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1; ... 33 3.0
UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2; R... 33 3.9
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 33 3.9
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 33 3.9
UniRef50_O16397 Cluster: Serpentine receptor, class h protein 19... 32 5.2
UniRef50_Q2UB49 Cluster: Predicted protein; n=1; Aspergillus ory... 32 5.2
UniRef50_UPI00015B5390 Cluster: PREDICTED: similar to sec-23 int... 32 6.8
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 32 6.8
UniRef50_UPI0000F2CDC4 Cluster: PREDICTED: similar to transmembr... 31 9.0
UniRef50_A1U9A1 Cluster: Butyryl-CoA dehydrogenase; n=29; Actino... 31 9.0
UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;... 31 9.0
UniRef50_Q44471 Cluster: Probable tartrate dehydrogenase/decarbo... 31 9.0
UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella pneumophi... 31 9.0
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 120 bits (288), Expect = 2e-26
Identities = 54/86 (62%), Positives = 67/86 (77%)
Frame = +3
Query: 24 IPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAI 203
IP AQYGGRHAVTMLPGGGIGPE MGYVR+IF+Y GAPIDFEV+DIDP+ + +DD+ YAI
Sbjct: 49 IPSAQYGGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEVIDIDPSTEGNDDLDYAI 108
Query: 204 TTIKXTVWG*RATLKPKXGSLCXVTQ 281
T+IK + ++ K SL V++
Sbjct: 109 TSIKRNGVALKGNIETKSQSLTEVSR 134
Score = 107 bits (256), Expect = 2e-22
Identities = 48/75 (64%), Positives = 60/75 (80%)
Frame = +1
Query: 232 KGQH*NQNXAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYA 411
KG ++ + SRNVA+RNELD+Y +++CKSYPG+ RH DIDVV+IRQNT+GEYA
Sbjct: 119 KGNIETKSQSLTEVSRNVAIRNELDLYVNVVHCKSYPGIPARHHDIDVVLIRQNTDGEYA 178
Query: 412 MLEHESVNGVVESMK 456
MLEHESV G+VESMK
Sbjct: 179 MLEHESVPGIVESMK 193
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 109 bits (262), Expect = 3e-23
Identities = 45/68 (66%), Positives = 57/68 (83%)
Frame = +3
Query: 12 KQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV 191
K + IPKA YGGRH VTMLPGGGIGPE M YV+++F++ G P+DFEVVDIDP + +DD+
Sbjct: 37 KVEKIPKAHYGGRHTVTMLPGGGIGPELMNYVKEVFRFAGVPVDFEVVDIDPASEGNDDL 96
Query: 192 QYAITTIK 215
+YAIT+IK
Sbjct: 97 EYAITSIK 104
Score = 103 bits (248), Expect = 1e-21
Identities = 48/75 (64%), Positives = 59/75 (78%)
Frame = +1
Query: 232 KGQH*NQNXAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYA 411
KG ++ A + SRNVALRNELD+Y +L+CKS+ + H+++DVVIIRQNTEGEYA
Sbjct: 111 KGNIETKSEATGIISRNVALRNELDLYVNVLHCKSFNAIPAHHQNVDVVIIRQNTEGEYA 170
Query: 412 MLEHESVNGVVESMK 456
MLEHESV GVVESMK
Sbjct: 171 MLEHESVRGVVESMK 185
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 99.1 bits (236), Expect = 4e-20
Identities = 48/82 (58%), Positives = 58/82 (70%), Gaps = 1/82 (1%)
Frame = +1
Query: 214 RXRCGAKGQ-H*NQNXAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQ 390
R R KG N N SRN LR LD+YA +++CKS PGV TRHKDID++I+R+
Sbjct: 109 RNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVRE 168
Query: 391 NTEGEYAMLEHESVNGVVESMK 456
NTEGEY+ LEHESV GVVES+K
Sbjct: 169 NTEGEYSSLEHESVAGVVESLK 190
Score = 72.5 bits (170), Expect = 4e-12
Identities = 31/68 (45%), Positives = 47/68 (69%)
Frame = +3
Query: 12 KQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV 191
+Q + P A+YGGRH VTM+PG GIGPE M +V+ +F++ P+DFE V + D ++D+
Sbjct: 42 EQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNAD-EEDI 100
Query: 192 QYAITTIK 215
+ AI I+
Sbjct: 101 RNAIMAIR 108
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 89.4 bits (212), Expect = 3e-17
Identities = 39/63 (61%), Positives = 53/63 (84%)
Frame = +1
Query: 268 VTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVE 447
V+S NV LR ELD++A ++NC + PG+ TRH+++D+V+IR+NTEGEYA LEHE V GVVE
Sbjct: 108 VSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYAGLEHEVVPGVVE 167
Query: 448 SMK 456
S+K
Sbjct: 168 SLK 170
Score = 39.5 bits (88), Expect = 0.034
Identities = 19/50 (38%), Positives = 27/50 (54%)
Frame = +3
Query: 24 IPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTM 173
+P+ G AVT++PG GIGP V + + + API FE D+ M
Sbjct: 29 MPRPGDGAPRAVTLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKYDVHGEM 78
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 87.0 bits (206), Expect = 2e-16
Identities = 37/61 (60%), Positives = 51/61 (83%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESM 453
S N+ LR LD++A I+ CKS PG+ TRH ++D+VIIRQNTEGEY+ LEHE+V+GV+E++
Sbjct: 132 SLNLELRVHLDLFANIVRCKSIPGIQTRHNNVDLVIIRQNTEGEYSHLEHENVSGVIENL 191
Query: 454 K 456
K
Sbjct: 192 K 192
Score = 66.1 bits (154), Expect = 3e-10
Identities = 32/68 (47%), Positives = 46/68 (67%), Gaps = 5/68 (7%)
Frame = +3
Query: 27 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDD-----V 191
P A+YGGR+ VT++PG GIGPE + V+DIF++IG P+DFE +++ D+D
Sbjct: 43 PPARYGGRNTVTLIPGDGIGPEMVVAVQDIFRHIGVPVDFEELNLSGLDIKDEDSYLGAF 102
Query: 192 QYAITTIK 215
AIT+IK
Sbjct: 103 NEAITSIK 110
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 87.0 bits (206), Expect = 2e-16
Identities = 37/63 (58%), Positives = 53/63 (84%)
Frame = +1
Query: 268 VTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVE 447
V+S N+ LR ELD++A ++NC + PG+ TRH+++D+V+IR+NTEGEY+ LEHE V GVVE
Sbjct: 109 VSSLNMQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEGEYSGLEHEVVPGVVE 168
Query: 448 SMK 456
S+K
Sbjct: 169 SLK 171
Score = 38.3 bits (85), Expect = 0.079
Identities = 16/46 (34%), Positives = 26/46 (56%)
Frame = +3
Query: 24 IPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI 161
+P+ G VT++PG GIGP G V + + + AP+ FE ++
Sbjct: 30 MPRPGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEV 75
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 86.6 bits (205), Expect = 2e-16
Identities = 37/61 (60%), Positives = 51/61 (83%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESM 453
S N+ LRNELD+YA +++ +S PGV TR++DID+V+IR+ TEGEY+ LEHESV G+VE +
Sbjct: 118 SLNMKLRNELDLYANVVHARSLPGVKTRYQDIDIVVIREQTEGEYSALEHESVPGIVECL 177
Query: 454 K 456
K
Sbjct: 178 K 178
Score = 44.8 bits (101), Expect = 0.001
Identities = 25/76 (32%), Positives = 42/76 (55%), Gaps = 4/76 (5%)
Frame = +3
Query: 27 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFE---VVDIDPTMDND-DDVQ 194
P A G R T++PG G+GPE + ++++FK P+DFE + +++P + +DV
Sbjct: 32 PGALGGNRTTCTLIPGDGVGPELVQCLQEVFKSADVPVDFECYFLSEVNPVLSAKLEDVI 91
Query: 195 YAITTIKXTVWG*RAT 242
+I K + G AT
Sbjct: 92 ASIRKNKVCIKGVLAT 107
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 81.4 bits (192), Expect = 9e-15
Identities = 40/61 (65%), Positives = 49/61 (80%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESM 453
S NVALR +LD++A + KS PGV TR +ID+VIIR+NTEGEY+ LEHESV GVVES+
Sbjct: 104 SLNVALRKQLDIFANVALFKSIPGVKTRLNNIDMVIIRENTEGEYSGLEHESVPGVVESL 163
Query: 454 K 456
K
Sbjct: 164 K 164
Score = 59.3 bits (137), Expect = 4e-08
Identities = 28/67 (41%), Positives = 46/67 (68%)
Frame = +3
Query: 15 QKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQ 194
++L+PK +YGGR+ VT++PG G+G E V IF+ PID+E +DI ++N ++VQ
Sbjct: 19 EQLLPK-KYGGRYTVTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDIS-GLENTENVQ 76
Query: 195 YAITTIK 215
A+ ++K
Sbjct: 77 RAVESLK 83
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 79.0 bits (186), Expect = 5e-14
Identities = 38/61 (62%), Positives = 48/61 (78%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESM 453
S NVALR +LD+YA + KS GV TR DID+++IR+NTEGE++ LEHESV GVVES+
Sbjct: 103 SLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESL 162
Query: 454 K 456
K
Sbjct: 163 K 163
Score = 55.2 bits (127), Expect = 6e-07
Identities = 27/67 (40%), Positives = 43/67 (64%)
Frame = +3
Query: 15 QKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQ 194
++ +PK +YGGR VT++PG G+G E VR IF+ PID+E ++I T D+ + V
Sbjct: 18 ERTLPK-KYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQT-DHKEGVY 75
Query: 195 YAITTIK 215
A+ ++K
Sbjct: 76 EAVESLK 82
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 77.8 bits (183), Expect = 1e-13
Identities = 30/63 (47%), Positives = 47/63 (74%)
Frame = +3
Query: 27 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAIT 206
P A+YGGRH VT++PG GIGPE + +VR++F++ P+DFEVV ++ + ++DD+ AI
Sbjct: 43 PPAKYGGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNSSSTSEDDISNAIM 102
Query: 207 TIK 215
I+
Sbjct: 103 AIR 105
Score = 60.1 bits (139), Expect = 2e-08
Identities = 25/53 (47%), Positives = 38/53 (71%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESV 432
SRN LR LD+YA +++C+S PGV TRHK+ID++II + +E + E+E +
Sbjct: 127 SRNNLLRTSLDLYANVMHCQSLPGVQTRHKNIDIIIILEKSEFSALLAENEKI 179
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 77.4 bits (182), Expect = 1e-13
Identities = 34/61 (55%), Positives = 46/61 (75%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESM 453
S N+ LR EL++YA + C S PG TR+ D+D++ IR+NTEGEY+ LEH+ V GVVES+
Sbjct: 121 SLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGEYSGLEHQVVKGVVESL 180
Query: 454 K 456
K
Sbjct: 181 K 181
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 76.2 bits (179), Expect = 3e-13
Identities = 32/63 (50%), Positives = 48/63 (76%)
Frame = +1
Query: 268 VTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVE 447
+ S ++ LR +LD++A +++ KS PG TRH ++D+VIIR+ TEGEY+ LEHES GV+E
Sbjct: 125 LASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIE 184
Query: 448 SMK 456
+K
Sbjct: 185 CLK 187
Score = 44.4 bits (100), Expect = 0.001
Identities = 19/59 (32%), Positives = 36/59 (61%), Gaps = 2/59 (3%)
Frame = +3
Query: 45 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDID--PTMDNDDDVQYAITTIK 215
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMK 105
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 73.3 bits (172), Expect = 2e-12
Identities = 30/56 (53%), Positives = 43/56 (76%)
Frame = +1
Query: 289 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMK 456
L LD+YA +++ K+ P V T HKD+D++++ +NTEGEY+ LEHESV GV ES+K
Sbjct: 2 LHTTLDLYASVIHLKNLPNVETWHKDVDILVVWENTEGEYSNLEHESVKGVTESLK 57
>UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8;
Eutheria|Rep: Isocitrate dehydrogenase 3 gamma - Homo
sapiens (Human)
Length = 88
Score = 70.9 bits (166), Expect = 1e-11
Identities = 31/68 (45%), Positives = 46/68 (67%)
Frame = +3
Query: 12 KQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV 191
+Q + P A+YGGRH VTM+PG GIGPE M +V+ +F++ P+DFE V + D ++D+
Sbjct: 15 EQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNAD-EEDI 73
Query: 192 QYAITTIK 215
AI I+
Sbjct: 74 CNAIMAIR 81
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 69.3 bits (162), Expect = 4e-11
Identities = 35/81 (43%), Positives = 51/81 (62%)
Frame = +1
Query: 214 RXRCGAKGQH*NQNXAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 393
R R G KG + +S NV LR ++YA + ++ PGV TR+ +D+V++R+N
Sbjct: 61 RTRIGLKGPVTTPIGGGF-SSINVELRKRFELYANVRPIRNLPGVHTRYPGVDLVVVREN 119
Query: 394 TEGEYAMLEHESVNGVVESMK 456
TEG Y+ +EHE V GVVES+K
Sbjct: 120 TEGLYSGIEHEVVPGVVESLK 140
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 68.1 bits (159), Expect = 9e-11
Identities = 31/61 (50%), Positives = 44/61 (72%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESM 453
S N+A+R E +YA + C+S G T + ++DVV IR+NTEGEY+ +EHE V GVV+S+
Sbjct: 102 SLNLAVRKEFSLYANVRPCRSLEGHKTLYDNVDVVTIRENTEGEYSGIEHEIVPGVVQSI 161
Query: 454 K 456
K
Sbjct: 162 K 162
Score = 43.6 bits (98), Expect = 0.002
Identities = 20/47 (42%), Positives = 27/47 (57%)
Frame = +3
Query: 42 GGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDND 182
G VT++PG GIGPE V+ IF+ API ++ VD+ P D
Sbjct: 22 GDVRRVTLIPGDGIGPEISASVQKIFEAADAPIAWDPVDVTPVKGRD 68
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 67.7 bits (158), Expect = 1e-10
Identities = 28/55 (50%), Positives = 43/55 (78%)
Frame = +1
Query: 292 RNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMK 456
R ELD++A +++C + G +RH+++D+V+IR+NTEGEYA EHE V GV+ES +
Sbjct: 70 RKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYAGREHEVVPGVIESFQ 124
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 66.9 bits (156), Expect = 2e-10
Identities = 29/60 (48%), Positives = 43/60 (71%)
Frame = +1
Query: 268 VTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVE 447
+ S ++ LR +LD++A +++ KS PG TRH ++D+VIIR+ TEGEY+ LEHE V E
Sbjct: 125 LASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHECCEEVAE 184
Score = 44.4 bits (100), Expect = 0.001
Identities = 19/59 (32%), Positives = 36/59 (61%), Gaps = 2/59 (3%)
Frame = +3
Query: 45 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDID--PTMDNDDDVQYAITTIK 215
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMK 105
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 65.3 bits (152), Expect = 6e-10
Identities = 31/66 (46%), Positives = 44/66 (66%)
Frame = +1
Query: 259 AAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNG 438
AA S N+ LR D+YA + C S G T + D+++V IR+NTEGEY+ +EH V+G
Sbjct: 104 AAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDG 163
Query: 439 VVESMK 456
VV+S+K
Sbjct: 164 VVQSIK 169
Score = 39.1 bits (87), Expect = 0.045
Identities = 19/44 (43%), Positives = 24/44 (54%)
Frame = +3
Query: 18 KLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFE 149
K + + GG VT++PG GIGPE V IF API +E
Sbjct: 21 KQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWE 64
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 63.3 bits (147), Expect = 2e-09
Identities = 27/51 (52%), Positives = 40/51 (78%)
Frame = +1
Query: 304 DMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMK 456
D+ A ++ +S P V TRHK+ID++++R NTEGEY+ LE ES+N VVES++
Sbjct: 17 DLCANVVQFESQPRVETRHKNIDILVVRDNTEGEYSNLEDESMNRVVESLR 67
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 57.6 bits (133), Expect = 1e-07
Identities = 26/51 (50%), Positives = 37/51 (72%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHE 426
S NVA+R ELD+YA + KS PG+ + +DID+V++R+NTE YA +E E
Sbjct: 80 SVNVAIRKELDLYANLRPAKSLPGIKSPFQDIDLVVVRENTEDLYAGIEFE 130
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 57.6 bits (133), Expect = 1e-07
Identities = 26/61 (42%), Positives = 41/61 (67%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESM 453
S N+ LR ++A + KS G T ++++D+V+IR+NTEGEY+ +EH GVV+S+
Sbjct: 113 SLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIRENTEGEYSGIEHIVCPGVVQSI 172
Query: 454 K 456
K
Sbjct: 173 K 173
Score = 39.9 bits (89), Expect = 0.026
Identities = 17/45 (37%), Positives = 25/45 (55%)
Frame = +3
Query: 45 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDN 179
G++ V+ + G GIGPE V+ IF PI++E D+ P N
Sbjct: 35 GKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVN 79
>UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subunit;
n=1; Pan troglodytes|Rep: Isocitrate dehydrogenase 3
gamma subunit - Pan troglodytes (Chimpanzee)
Length = 165
Score = 57.2 bits (132), Expect = 2e-07
Identities = 24/37 (64%), Positives = 30/37 (81%)
Frame = +3
Query: 27 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAP 137
P A+YGGRH VTM+PG GIGPE M +V+ +F+Y GAP
Sbjct: 105 PSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRY-GAP 140
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 56.4 bits (130), Expect = 3e-07
Identities = 29/62 (46%), Positives = 38/62 (61%), Gaps = 1/62 (1%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSY-PGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVES 450
S NVALR L +Y + C SY P V T+H D+DVVIIR+N E Y+ +EH+ E
Sbjct: 86 SLNVALRQRLGLYVNVRPCVSYFPVVGTKHPDLDVVIIRENEEDTYSGVEHKLSEDTHEC 145
Query: 451 MK 456
+K
Sbjct: 146 VK 147
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 54.4 bits (125), Expect = 1e-06
Identities = 24/53 (45%), Positives = 38/53 (71%)
Frame = +1
Query: 268 VTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHE 426
+ S NVALR LD+YA + ++ PGV +R+ +ID+V++R+NTE Y+ +E E
Sbjct: 79 IRSVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRENTEDLYSGIEFE 131
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 54.4 bits (125), Expect = 1e-06
Identities = 26/58 (44%), Positives = 36/58 (62%)
Frame = +1
Query: 283 VALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMK 456
V LR DMYA I KS PG+ T++ ++D++I+R+NTE Y EH +GV MK
Sbjct: 83 VKLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVRENTEDLYKGFEHIVSDGVAVGMK 140
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 50.8 bits (116), Expect = 1e-05
Identities = 26/54 (48%), Positives = 36/54 (66%), Gaps = 2/54 (3%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRHKD--IDVVIIRQNTEGEYAMLEHES 429
S NV LR EL +YA I CK+Y GV T D +D+V++R+NTE YA +E ++
Sbjct: 78 SVNVFLRQELGLYACIRPCKTYKGVRTYFADSNVDLVVVRENTEDLYAGVEFQA 131
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 49.6 bits (113), Expect = 3e-05
Identities = 26/53 (49%), Positives = 32/53 (60%)
Frame = +1
Query: 283 VALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGV 441
V LR+ LD YA I K+Y GV DID VI+R+NTEG Y +E E G+
Sbjct: 78 VKLRHILDTYANIRPVKAYKGVKCLRPDIDYVIVRENTEGLYKGIEAEIDEGI 130
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 48.8 bits (111), Expect = 6e-05
Identities = 21/56 (37%), Positives = 35/56 (62%)
Frame = +1
Query: 289 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVESMK 456
+R + +AY+ C G+ + + D DVVIIR EG+Y+ +EH V GV++++K
Sbjct: 143 IRKQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEGDYSGIEHLVVPGVMQTIK 198
Score = 35.5 bits (78), Expect = 0.56
Identities = 16/43 (37%), Positives = 27/43 (62%)
Frame = +3
Query: 57 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDD 185
VT++ G G+G E M V+++ + API+++V D D+DD
Sbjct: 72 VTLINGEGVGRELMDAVQEVICAVKAPIEWDVHDEFKAKDSDD 114
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 48.4 bits (110), Expect = 7e-05
Identities = 27/62 (43%), Positives = 36/62 (58%), Gaps = 1/62 (1%)
Frame = +1
Query: 274 SRNVALRNELDMYAYIL-NCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVES 450
S NV LR L +YA + +C +P V T +IDVVIIR+N E YA +E+ ES
Sbjct: 83 SLNVTLRKTLGLYANVRPSCSYFPFVNTSAPEIDVVIIRENEEDLYAGIEYHHTADTYES 142
Query: 451 MK 456
+K
Sbjct: 143 VK 144
>UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila
melanogaster|Rep: IP13250p - Drosophila melanogaster
(Fruit fly)
Length = 475
Score = 48.0 bits (109), Expect = 1e-04
Identities = 22/71 (30%), Positives = 38/71 (53%)
Frame = +1
Query: 241 H*NQNXAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLE 420
H + A + + + N+LD+Y + +S+PG R +D+ +I QN G + LE
Sbjct: 118 HVDNQADAEAKQKALKICNDLDLYVFKTRTRSFPGFKCRFPGVDIQLIGQNNMGIFNELE 177
Query: 421 HESVNGVVESM 453
+ V GVVE++
Sbjct: 178 YSPVEGVVEAL 188
>UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 106
Score = 46.8 bits (106), Expect = 2e-04
Identities = 24/58 (41%), Positives = 30/58 (51%)
Frame = +3
Query: 12 KQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDD 185
+Q + P A+YGG VTM PG G GPE M V P+DFE V + D +D
Sbjct: 3 QQTIPPSAKYGGILTVTMSPGDGDGPELMLTVXXXXXSACVPVDFEEVVVSSNADEED 60
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 46.4 bits (105), Expect = 3e-04
Identities = 21/54 (38%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Frame = +1
Query: 268 VTSRNVALRNELDMYAYILNCKSYPGVATRHK---DIDVVIIRQNTEGEYAMLE 420
+ S NVALR D+Y + C+ YPG + HK +D+++ R+NTE Y +E
Sbjct: 111 IRSLNVALRQIFDLYTCVRPCRYYPGTPSPHKTPEKLDIIVYRENTEDIYLGIE 164
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 46.0 bits (104), Expect = 4e-04
Identities = 22/42 (52%), Positives = 27/42 (64%)
Frame = +1
Query: 283 VALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEY 408
V LR LD+YA I KSYP + DID+VI+R+NTE Y
Sbjct: 82 VVLRRMLDLYANIRPAKSYPHMPALRDDIDMVIVRENTEDLY 123
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 46.0 bits (104), Expect = 4e-04
Identities = 23/54 (42%), Positives = 31/54 (57%)
Frame = +1
Query: 283 VALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVV 444
V LR E D++A + KS PGV + D+D VI+R+NTE Y E + G V
Sbjct: 80 VRLRREFDLFANLRPVKSLPGVPCLYPDLDFVIVRENTEDLYVGDEEYTPEGAV 133
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 45.6 bits (103), Expect = 5e-04
Identities = 22/63 (34%), Positives = 36/63 (57%), Gaps = 2/63 (3%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRH--KDIDVVIIRQNTEGEYAMLEHESVNGVVE 447
S NV LR + YA + + +P V T + + ID+V++R+N E YA +EH V +
Sbjct: 98 SANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVVRENVEDLYAGIEHMQTPSVAQ 157
Query: 448 SMK 456
++K
Sbjct: 158 TLK 160
Score = 38.3 bits (85), Expect = 0.079
Identities = 15/36 (41%), Positives = 23/36 (63%)
Frame = +3
Query: 45 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEV 152
GR +T++PG GIGPEC+ + + AP+ +EV
Sbjct: 18 GRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEV 53
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 44.8 bits (101), Expect = 0.001
Identities = 21/49 (42%), Positives = 29/49 (59%)
Frame = +1
Query: 292 RNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNG 438
R LD+YA + ++Y G R D D+V++R+NTEG YA E NG
Sbjct: 104 RKNLDLYANVRPARTYAGRPGRLGDFDLVVVRENTEGFYADRNMEQGNG 152
>UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=73; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Staphylococcus epidermidis (strain ATCC 35984 /
RP62A)
Length = 422
Score = 44.8 bits (101), Expect = 0.001
Identities = 24/65 (36%), Positives = 39/65 (60%), Gaps = 3/65 (4%)
Frame = +1
Query: 268 VTSRNVALRNELDMYAYILNCKSYPGVAT---RHKDIDVVIIRQNTEGEYAMLEHESVNG 438
+ S NVALR ELD++ + + + GV + R +D+D+VI R+NTE YA +E +
Sbjct: 101 IRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPEDVDMVIFRENTEDIYAGIEFKQGTS 160
Query: 439 VVESM 453
V+ +
Sbjct: 161 EVKKV 165
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 44.4 bits (100), Expect = 0.001
Identities = 19/59 (32%), Positives = 36/59 (61%), Gaps = 2/59 (3%)
Frame = +3
Query: 45 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDID--PTMDNDDDVQYAITTIK 215
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 15 GAFPVTMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQVLSSMK 73
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 42.3 bits (95), Expect = 0.005
Identities = 20/52 (38%), Positives = 34/52 (65%), Gaps = 3/52 (5%)
Frame = +1
Query: 265 YVTSRN-VALRNELDMYAYILNCKSYPGVATRHK--DIDVVIIRQNTEGEYA 411
YVT + +R +LD + + K +PG+ T K +IDV+++R+N+EGEY+
Sbjct: 87 YVTLEPLIQMRQQLDQFLCLRPAKHFPGIPTPLKKCEIDVLVVRENSEGEYS 138
Score = 33.1 bits (72), Expect = 3.0
Identities = 13/37 (35%), Positives = 21/37 (56%)
Frame = +3
Query: 48 RHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVD 158
+H + ++PG GIG E M +F+ + PI + VD
Sbjct: 10 QHKIIVIPGDGIGAEVMNEAEKMFQSLNLPIQRDYVD 46
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 42.3 bits (95), Expect = 0.005
Identities = 19/41 (46%), Positives = 28/41 (68%)
Frame = +1
Query: 289 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYA 411
+R D++A I +S GVA+ D+D+VI+R+NTEG YA
Sbjct: 102 VRKRFDLFANIRPARSLEGVASTVPDMDLVIVRENTEGLYA 142
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 41.9 bits (94), Expect = 0.006
Identities = 17/38 (44%), Positives = 25/38 (65%)
Frame = +1
Query: 289 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEG 402
LR D++A + +SYPG+ DID+VI+R+N EG
Sbjct: 95 LRKGFDLFANVRPTRSYPGIGCLFDDIDLVIVRENNEG 132
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 41.5 bits (93), Expect = 0.008
Identities = 19/47 (40%), Positives = 29/47 (61%)
Frame = +1
Query: 283 VALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEH 423
V LR ELD++A I K PGV +++D++I+R+N E Y E+
Sbjct: 82 VRLRRELDLFANIRPAKVLPGVPALKENVDLIIVRENIEDLYVGAEN 128
>UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=4; Chloroflexaceae|Rep: Isocitrate dehydrogenase,
NADP-dependent - Roseiflexus sp. RS-1
Length = 453
Score = 40.7 bits (91), Expect = 0.015
Identities = 25/66 (37%), Positives = 39/66 (59%), Gaps = 3/66 (4%)
Frame = +1
Query: 268 VTSRNVALRNELDMYAYILNCKSYPGVAT---RHKDIDVVIIRQNTEGEYAMLEHESVNG 438
+ S NVALR LD+Y + + + GV + R + +D+VI R+NTE YA +E+ + G
Sbjct: 109 IRSLNVALRQLLDLYVCLRPVRYFQGVPSPVKRPELVDMVIFRENTEDIYAGIEYAA--G 166
Query: 439 VVESMK 456
E+ K
Sbjct: 167 TPEAQK 172
>UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 230
Score = 40.7 bits (91), Expect = 0.015
Identities = 22/58 (37%), Positives = 31/58 (53%)
Frame = -3
Query: 453 H*LDHTIHGFVFQHSVFTFCVLSDNNNINVLMSGRNARVRFTVQYVSIHVQFVSESHI 280
H L+HT VFQ +FTF V SD +N L + +A F S ++QF S+ +I
Sbjct: 77 HRLNHTRVRLVFQSRIFTFSVFSDEGKVNALQTRLDAGNVFDQDQRSKNIQFFSQRNI 134
>UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 419
Score = 39.9 bits (89), Expect = 0.026
Identities = 21/54 (38%), Positives = 33/54 (61%), Gaps = 3/54 (5%)
Frame = +1
Query: 268 VTSRNVALRNELDMYAYILNCKSYPGVATRHK---DIDVVIIRQNTEGEYAMLE 420
+ S NVALR +LD+Y + + + GV + K D+D+ I R+N+E YA +E
Sbjct: 113 IRSLNVALRQQLDLYVCLRPVRWFEGVPSPVKKPGDVDMTIFRENSEDIYAGIE 166
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 39.5 bits (88), Expect = 0.034
Identities = 24/64 (37%), Positives = 36/64 (56%), Gaps = 3/64 (4%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRHKD---IDVVIIRQNTEGEYAMLEHESVNGVV 444
S NVALR LD+YA + GV + K+ +D++ R+NTE YA +E E+ V
Sbjct: 155 SLNVALRKTLDLYANVRPTYYLDGVPSPVKNPEKMDMITFRENTEDVYAGIEWEAGTDEV 214
Query: 445 ESMK 456
E ++
Sbjct: 215 EQVR 218
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 39.5 bits (88), Expect = 0.034
Identities = 22/47 (46%), Positives = 28/47 (59%), Gaps = 5/47 (10%)
Frame = +1
Query: 292 RNELDMYAYILNCKSYPGV----ATRHK-DIDVVIIRQNTEGEYAML 417
R E D Y I + +PGV A R DID V++R+NTEGEY+ L
Sbjct: 98 RREFDQYVNIRPVRLFPGVPCALANRKVGDIDFVVVRENTEGEYSSL 144
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 37.9 bits (84), Expect = 0.10
Identities = 20/46 (43%), Positives = 29/46 (63%)
Frame = +1
Query: 283 VALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLE 420
VALR E+ ++A + KS G + K ID+VI+R+NTE Y +E
Sbjct: 111 VALRREMGLFANVRPVKSVEG--EKGKPIDMVIVRENTEDLYIKIE 154
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 37.1 bits (82), Expect = 0.18
Identities = 22/63 (34%), Positives = 35/63 (55%), Gaps = 2/63 (3%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSY--PGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVVE 447
S NVALR ++D+Y + + Y P + +D+VI R+N+E YA +E + G E
Sbjct: 123 SLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVDMVIFRENSEDIYAGIEWQ--EGSAE 180
Query: 448 SMK 456
+ K
Sbjct: 181 AKK 183
>UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp -
Pasteurella multocida
Length = 415
Score = 36.7 bits (81), Expect = 0.24
Identities = 20/54 (37%), Positives = 33/54 (61%), Gaps = 3/54 (5%)
Frame = +1
Query: 268 VTSRNVALRNELDMYAYILNCKSYPGVAT--RHKD-IDVVIIRQNTEGEYAMLE 420
+ S NVA+R LD+Y + + Y G + +H + +D+VI R+N+E YA +E
Sbjct: 111 IRSLNVAMRQGLDLYNCLRPIRYYDGTPSPVKHPELVDMVIFRENSEDIYAGVE 164
>UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenase;
n=1; Plesiocystis pacifica SIR-1|Rep: Probable
3-isopropylmalate dehydrogenase - Plesiocystis pacifica
SIR-1
Length = 368
Score = 36.7 bits (81), Expect = 0.24
Identities = 24/50 (48%), Positives = 29/50 (58%), Gaps = 10/50 (20%)
Frame = +1
Query: 292 RNELDMYAYILNCKSYPGVATR----HKDI------DVVIIRQNTEGEYA 411
R L++YA + K YPGV R HK I D+VIIR+NTEG YA
Sbjct: 87 RMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAGKVDMVIIRENTEGLYA 136
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 36.3 bits (80), Expect = 0.32
Identities = 20/46 (43%), Positives = 29/46 (63%), Gaps = 3/46 (6%)
Frame = +1
Query: 283 VALRNELDMYAYILNCKSYPGVAT---RHKDIDVVIIRQNTEGEYA 411
+ LR +LD++A + K Y GV + R ID VI+R+N+EG YA
Sbjct: 93 LTLRFKLDLFANVRPIKLYKGVPSPLGRPGPIDYVIVRENSEGLYA 138
>UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 90
Score = 36.3 bits (80), Expect = 0.32
Identities = 18/37 (48%), Positives = 20/37 (54%)
Frame = +3
Query: 42 GGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEV 152
GG VT++PG GIGPE V IF API V
Sbjct: 2 GGVKTVTLIPGDGIGPEISAAVMKIFDAAKAPIQANV 38
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 35.9 bits (79), Expect = 0.42
Identities = 20/47 (42%), Positives = 28/47 (59%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAM 414
S NVA+R ELD++A + V+ + ID V R+NTEGEY +
Sbjct: 104 SANVAMRRELDLFANVRP------VSIPSEGIDWVFFRENTEGEYVL 144
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 35.5 bits (78), Expect = 0.56
Identities = 21/55 (38%), Positives = 30/55 (54%), Gaps = 3/55 (5%)
Frame = +1
Query: 283 VALRNELDMYAYI---LNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNG 438
V LR ELD+YA I + G R + +D+V++R+NTE YA E +G
Sbjct: 88 VRLRRELDLYANIRPVFDDLPENGSNPRRRKVDLVVVRENTEDVYAGRERVEDDG 142
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 35.5 bits (78), Expect = 0.56
Identities = 16/46 (34%), Positives = 26/46 (56%)
Frame = +1
Query: 283 VALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLE 420
V LR EL +A + K+ G+ + +D+V++R+NTE Y E
Sbjct: 78 VRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTECLYMGFE 123
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 35.1 bits (77), Expect = 0.73
Identities = 14/42 (33%), Positives = 26/42 (61%)
Frame = +1
Query: 283 VALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEY 408
V++R + D+YA + K++P D+++V +R+ TEG Y
Sbjct: 86 VSIRRKYDLYANVRPIKTFPNSNAPLGDVEMVCVREGTEGLY 127
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 34.7 bits (76), Expect = 0.97
Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 5/48 (10%)
Frame = +1
Query: 283 VALRNELDMYAYILNCKSYPGV-----ATRHKDIDVVIIRQNTEGEYA 411
+ R E D Y + + + GV + DID +I+R+NTEGEY+
Sbjct: 95 IKFRREFDQYVNLRPARLFDGVPCPLAGRKAGDIDFMIVRENTEGEYS 142
>UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: 3-isopropylmalate
dehydrogenase - Victivallis vadensis ATCC BAA-548
Length = 369
Score = 34.7 bits (76), Expect = 0.97
Identities = 18/45 (40%), Positives = 27/45 (60%), Gaps = 5/45 (11%)
Frame = +1
Query: 289 LRNELDMYAYILNCKSYPGVAT-----RHKDIDVVIIRQNTEGEY 408
LR +LD Y + K +PGV T + +DID V++R+N+ G Y
Sbjct: 94 LRFDLDQYINLRPVKLFPGVETPLANKKPEDIDYVVVRENSGGVY 138
>UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-isopropylmalate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 478
Score = 34.7 bits (76), Expect = 0.97
Identities = 17/43 (39%), Positives = 26/43 (60%), Gaps = 3/43 (6%)
Frame = +1
Query: 289 LRNELDMYAYILNCKSYPGVAT---RHKDIDVVIIRQNTEGEY 408
LR ELD Y + + +PGVA+ ++D V++R+ TEG Y
Sbjct: 224 LRFELDHYVNLRPSRIFPGVASPLANPGEVDFVVVREGTEGPY 266
>UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2;
Deinococcus|Rep: Isocitrate dehydrogenase, putative -
Deinococcus radiodurans
Length = 333
Score = 34.3 bits (75), Expect = 1.3
Identities = 16/44 (36%), Positives = 29/44 (65%)
Frame = +1
Query: 289 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLE 420
LR + ++YA + K+ P V ++++D+VI+R+NT+G Y E
Sbjct: 89 LRQKYNLYANVRPTKTRP-VPHSYENVDLVIVRENTQGLYVEQE 131
>UniRef50_A3Y262 Cluster: Phosphorelay protein; n=4;
Vibrionales|Rep: Phosphorelay protein - Vibrio sp.
MED222
Length = 114
Score = 34.3 bits (75), Expect = 1.3
Identities = 12/27 (44%), Positives = 21/27 (77%)
Frame = -1
Query: 152 HFEVNRSTDVFEYVANVSHALRTDTAS 72
H E+N+ +D +Y+A++SHAL++ AS
Sbjct: 39 HLELNKESDTSKYLADISHALKSSAAS 65
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 33.9 bits (74), Expect = 1.7
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 3/44 (6%)
Frame = +1
Query: 289 LRNELDMYAYILNCKSYPGVATR---HKDIDVVIIRQNTEGEYA 411
+R Y KS PG+++ DID VI R+N EGEY+
Sbjct: 94 IRKNFQQYVNFRPIKSLPGISSPLAGGNDIDFVIFRENAEGEYS 137
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 33.5 bits (73), Expect = 2.2
Identities = 14/31 (45%), Positives = 20/31 (64%)
Frame = +3
Query: 57 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFE 149
VT++PG GIGPE + V +F +G P +E
Sbjct: 12 VTLIPGDGIGPEIVDVVVRVFDALGNPFAWE 42
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 33.5 bits (73), Expect = 2.2
Identities = 19/42 (45%), Positives = 23/42 (54%), Gaps = 2/42 (4%)
Frame = +1
Query: 289 LRNELDMYAYILNCKSYPGVAT--RHKDIDVVIIRQNTEGEY 408
LR LD YA + PGV R +D VI+R+NTEG Y
Sbjct: 98 LRGGLDTYANVRPIALLPGVDAPLRGTAVDYVIVRENTEGLY 139
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 33.5 bits (73), Expect = 2.2
Identities = 19/43 (44%), Positives = 27/43 (62%)
Frame = +1
Query: 283 VALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYA 411
V LR ELD+YA N + P ++ ++VI+R+NTEG YA
Sbjct: 83 VTLRKELDLYA---NLRIIPDLSNGK---EIVIVRENTEGLYA 119
>UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 173
Score = 33.1 bits (72), Expect = 3.0
Identities = 19/40 (47%), Positives = 21/40 (52%)
Frame = -2
Query: 157 STTSKSIGAPMYLNMSRTYPMHSGPIPPPGSMVTA*RPPY 38
ST S S+G L M T + S PIP PG VT PPY
Sbjct: 70 STVSHSMGTFSDLKMVLTESVISLPIPSPGMRVTVYLPPY 109
>UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Rhodobacterales|Rep: 3-isopropylmalate dehydrogenase -
Stappia aggregata IAM 12614
Length = 369
Score = 32.7 bits (71), Expect = 3.9
Identities = 18/48 (37%), Positives = 28/48 (58%), Gaps = 5/48 (10%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRHKD-----IDVVIIRQNTEG 402
S ++ LR+ +YA + K+YP R D ID+VI+R++TEG
Sbjct: 87 SPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRAAGIDLVILRESTEG 134
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 32.7 bits (71), Expect = 3.9
Identities = 19/44 (43%), Positives = 25/44 (56%), Gaps = 3/44 (6%)
Frame = +1
Query: 289 LRNELDMYAYILNCKSYPGVATRHKD---IDVVIIRQNTEGEYA 411
+R ELD+Y + K Y T K ID+V +R+NTEG YA
Sbjct: 92 MRFELDLYVNLRPVKLYHPRLTPLKGKNKIDIVFVRENTEGLYA 135
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 32.7 bits (71), Expect = 3.9
Identities = 18/46 (39%), Positives = 26/46 (56%)
Frame = +1
Query: 283 VALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLE 420
V LR + D+YA I K+Y + T + +D V R+ TEG Y +E
Sbjct: 88 VTLRQKFDLYANIRPTKTYDRL-TPDRKLDCVCFREATEGLYTGVE 132
>UniRef50_O16397 Cluster: Serpentine receptor, class h protein 190;
n=1; Caenorhabditis elegans|Rep: Serpentine receptor,
class h protein 190 - Caenorhabditis elegans
Length = 333
Score = 32.3 bits (70), Expect = 5.2
Identities = 12/25 (48%), Positives = 17/25 (68%)
Frame = +3
Query: 87 PECMGYVRDIFKYIGAPIDFEVVDI 161
PE GY IFKY AP+++ VV++
Sbjct: 79 PELAGYPLGIFKYFNAPVEYYVVEV 103
>UniRef50_Q2UB49 Cluster: Predicted protein; n=1; Aspergillus
oryzae|Rep: Predicted protein - Aspergillus oryzae
Length = 401
Score = 32.3 bits (70), Expect = 5.2
Identities = 17/40 (42%), Positives = 21/40 (52%)
Frame = -2
Query: 166 GSMSTTSKSIGAPMYLNMSRTYPMHSGPIPPPGSMVTA*R 47
G +T K I LN+ RT GP+PPP SM+ A R
Sbjct: 146 GHYTTEQKEIVIHQKLNVVRTAERERGPVPPPLSMLYAER 185
>UniRef50_UPI00015B5390 Cluster: PREDICTED: similar to sec-23
interacting protein P125; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to sec-23 interacting protein P125 -
Nasonia vitripennis
Length = 1368
Score = 31.9 bits (69), Expect = 6.8
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 1/39 (2%)
Frame = -2
Query: 184 SSLSIVGSMST-TSKSIGAPMYLNMSRTYPMHSGPIPPP 71
S+ SI S S TS + APMY+ M T P+ + P+ PP
Sbjct: 1321 STPSISASPSNVTSPTAAAPMYVGMDPTAPISAKPVGPP 1359
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 31.9 bits (69), Expect = 6.8
Identities = 18/64 (28%), Positives = 37/64 (57%), Gaps = 3/64 (4%)
Frame = +1
Query: 274 SRNVALRNELDMYAYILNCKSYPGVATRHKD---IDVVIIRQNTEGEYAMLEHESVNGVV 444
S NVALR E+D++ + K + + + K+ ++ ++R ++E Y+ +E ++ G +
Sbjct: 114 SLNVALRQEMDLFVNMRTIKGFSALPSPLKNPFLTNITVLRDSSEDVYSGIEWQA--GSI 171
Query: 445 ESMK 456
ES K
Sbjct: 172 ESEK 175
>UniRef50_UPI0000F2CDC4 Cluster: PREDICTED: similar to transmembrane
receptor precusor; n=1; Monodelphis domestica|Rep:
PREDICTED: similar to transmembrane receptor precusor -
Monodelphis domestica
Length = 412
Score = 31.5 bits (68), Expect = 9.0
Identities = 16/42 (38%), Positives = 23/42 (54%)
Frame = +1
Query: 34 RNTAVVTR*PCSLEAVSVLSAWDTFATYSNTSVLLLTSKWWT 159
++T V + P S A VLS DT + S +L+T +WWT
Sbjct: 326 QHTDVEPKRPDSRTAQCVLSVRDTTISTEKESTILITFQWWT 367
>UniRef50_A1U9A1 Cluster: Butyryl-CoA dehydrogenase; n=29;
Actinomycetales|Rep: Butyryl-CoA dehydrogenase -
Mycobacterium sp. (strain KMS)
Length = 385
Score = 31.5 bits (68), Expect = 9.0
Identities = 13/27 (48%), Positives = 16/27 (59%)
Frame = +1
Query: 322 LNCKSYPGVATRHKDIDVVIIRQNTEG 402
L CK+ P RHK I VV++ Q T G
Sbjct: 167 LLCKTDPSATPRHKGISVVLVEQGTTG 193
>UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
2 - Pyrococcus furiosus
Length = 355
Score = 31.5 bits (68), Expect = 9.0
Identities = 20/44 (45%), Positives = 24/44 (54%), Gaps = 3/44 (6%)
Frame = +1
Query: 289 LRNELDMYAYILNCKSYPGVATRHKD---IDVVIIRQNTEGEYA 411
LR LD+Y + K Y T K ID+V IR+NTEG YA
Sbjct: 91 LRFSLDLYVNLRPVKLYHPKLTPLKGKEKIDMVFIRENTEGLYA 134
>UniRef50_Q44471 Cluster: Probable tartrate
dehydrogenase/decarboxylase ttuC; n=66; cellular
organisms|Rep: Probable tartrate
dehydrogenase/decarboxylase ttuC - Agrobacterium vitis
(Rhizobium vitis)
Length = 364
Score = 31.5 bits (68), Expect = 9.0
Identities = 16/41 (39%), Positives = 24/41 (58%), Gaps = 5/41 (12%)
Frame = +1
Query: 304 DMYAYILNCKSYPGVATRHK-----DIDVVIIRQNTEGEYA 411
D YA + K PG+ + D+D VI+R+N+EGEY+
Sbjct: 99 DQYANVRPTKILPGITPPLRNCGPGDLDWVIVRENSEGEYS 139
>UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella
pneumophila|Rep: Protein dlpA - Legionella pneumophila
subsp. pneumophila (strain Philadelphia 1 /ATCC 33152 /
DSM 7513)
Length = 615
Score = 31.5 bits (68), Expect = 9.0
Identities = 18/63 (28%), Positives = 32/63 (50%)
Frame = +1
Query: 265 YVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVNGVV 444
Y S + LR LD++A + C S + + K + IIR+N+EG Y ++ + +
Sbjct: 96 YYVSPVIQLRQGLDLFANVRPCFS---IDDQSKPFNFCIIRENSEGLYCGFDYFPLPKAI 152
Query: 445 ESM 453
S+
Sbjct: 153 HSL 155
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 486,687,353
Number of Sequences: 1657284
Number of extensions: 9602643
Number of successful extensions: 28559
Number of sequences better than 10.0: 80
Number of HSP's better than 10.0 without gapping: 27510
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 28539
length of database: 575,637,011
effective HSP length: 94
effective length of database: 419,852,315
effective search space used: 24351434270
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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