Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= wdS00186
(659 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P40320 Cluster: S-adenosylmethionine synthetase; n=19; ... 160 2e-38
UniRef50_Q00266 Cluster: S-adenosylmethionine synthetase isoform... 137 3e-31
UniRef50_P19358 Cluster: S-adenosylmethionine synthetase 2; n=65... 109 8e-23
UniRef50_Q2U8T6 Cluster: S-adenosylmethionine synthetase; n=2; A... 103 5e-21
UniRef50_Q837P9 Cluster: S-adenosylmethionine synthetase; n=45; ... 103 5e-21
UniRef50_Q9K7Q9 Cluster: S-adenosylmethionine synthetase; n=65; ... 101 2e-20
UniRef50_Q7QWJ4 Cluster: S-adenosylmethionine synthetase; n=1; G... 99 8e-20
UniRef50_P0A820 Cluster: S-adenosylmethionine synthetase; n=23; ... 97 4e-19
UniRef50_Q1GND0 Cluster: S-adenosylmethionine synthetase; n=29; ... 96 6e-19
UniRef50_O09486 Cluster: S-adenosylmethionine synthetase; n=1; A... 95 2e-18
UniRef50_Q5EK82 Cluster: S-adenosyl methionine synthetase 2; n=6... 93 7e-18
UniRef50_Q6SZ22 Cluster: S-adenosylmethionine synthetase; n=4; S... 90 5e-17
UniRef50_A7APP7 Cluster: S-adenosylmethionine synthetase, putati... 88 2e-16
UniRef50_P72871 Cluster: S-adenosylmethionine synthetase; n=119;... 88 2e-16
UniRef50_Q4A5F4 Cluster: S-adenosylmethionine synthetase; n=4; B... 86 6e-16
UniRef50_Q650L4 Cluster: S-adenosylmethionine synthetase; n=19; ... 85 1e-15
UniRef50_UPI00015BD1C2 Cluster: UPI00015BD1C2 related cluster; n... 85 1e-15
UniRef50_A5BU08 Cluster: Putative uncharacterized protein; n=1; ... 83 4e-15
UniRef50_Q661P3 Cluster: S-adenosylmethionine synthetase; n=3; B... 83 4e-15
UniRef50_Q7NB16 Cluster: S-adenosylmethionine synthetase; n=2; M... 82 1e-14
UniRef50_Q6KHY1 Cluster: S-adenosylmethionine synthetase; n=7; M... 82 1e-14
UniRef50_Q2GDS4 Cluster: S-adenosylmethionine synthetase; n=1; N... 81 2e-14
UniRef50_A6QA94 Cluster: S-adenosylmethionine synthetase; n=20; ... 79 7e-14
UniRef50_A6BGC6 Cluster: S-adenosylmethionine synthetase; n=1; D... 79 1e-13
UniRef50_Q6A7D8 Cluster: S-adenosylmethionine synthetase; n=11; ... 77 5e-13
UniRef50_P78003 Cluster: S-adenosylmethionine synthetase; n=4; M... 77 5e-13
UniRef50_Q1VNA9 Cluster: S-adenosylmethionine synthetase; n=1; P... 74 3e-12
UniRef50_UPI000039A2E5 Cluster: COG0192: S-adenosylmethionine sy... 74 4e-12
UniRef50_Q5FGR4 Cluster: S-adenosylmethionine synthetase; n=13; ... 74 4e-12
UniRef50_Q60BL6 Cluster: S-adenosylmethionine synthetase; n=6; B... 65 2e-09
UniRef50_Q0GGP1 Cluster: S-adenosylmethionine synthetase; n=2; A... 61 3e-08
UniRef50_Q027Y1 Cluster: Methionine adenosyltransferase; n=1; So... 60 4e-08
UniRef50_Q2LSR0 Cluster: S-adenosylmethionine synthetase; n=1; S... 54 4e-06
UniRef50_Q0JN66 Cluster: Os01g0323600 protein; n=1; Oryza sativa... 52 9e-06
UniRef50_Q9S992 Cluster: MET adenosyltransferase homolog; n=3; c... 45 0.001
UniRef50_Q42242 Cluster: S-adenosyl methionine synthase; n=5; Eu... 44 0.003
UniRef50_A6PKG8 Cluster: Methionine adenosyltransferase precurso... 43 0.008
UniRef50_Q09A96 Cluster: Putative uncharacterized protein; n=1; ... 39 0.12
UniRef50_A2Y188 Cluster: Putative uncharacterized protein; n=1; ... 36 0.65
UniRef50_Q6MA58 Cluster: Putative uncharacterized protein; n=1; ... 36 1.1
UniRef50_A2VEZ2 Cluster: RT01136p; n=1; Drosophila melanogaster|... 36 1.1
UniRef50_A0U6S4 Cluster: Putative uncharacterized protein precur... 35 2.0
UniRef50_A3J8N0 Cluster: Signal transduction histidine kinase; n... 33 4.6
UniRef50_P15557 Cluster: Acylase ACY 1 [Includes: Cephalosporin ... 33 4.6
UniRef50_Q12WV1 Cluster: Putative uncharacterized protein; n=1; ... 33 6.1
>UniRef50_P40320 Cluster: S-adenosylmethionine synthetase; n=19;
Eukaryota|Rep: S-adenosylmethionine synthetase -
Drosophila melanogaster (Fruit fly)
Length = 408
Score = 160 bits (389), Expect = 2e-38
Identities = 69/87 (79%), Positives = 81/87 (93%)
Frame = +2
Query: 248 QGGLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNL 427
+ GLC+RC+VQV+YAIG+AEPLSITVFDYGTSHK+Q++LL I+++NFDLRPGKIVK+LNL
Sbjct: 318 KAGLCKRCLVQVSYAIGLAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNL 377
Query: 428 RAPIYQRTSTYGHFGRAGFPWESPKPL 508
R PIYQRTSTYGHFGRAGF WE KPL
Sbjct: 378 RQPIYQRTSTYGHFGRAGFSWEEAKPL 404
Score = 130 bits (313), Expect = 4e-29
Identities = 60/84 (71%), Positives = 66/84 (78%)
Frame = +3
Query: 3 KVIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXX 182
KV+K VIPA+Y+D T++HINPCGLF+IGGP DAGLTGRKIIVDTY
Sbjct: 236 KVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSG 295
Query: 183 KDFTKVDRSAAYAARWVAKSLVKA 254
KDFTKVDRSAAYAARWVAKSLVKA
Sbjct: 296 KDFTKVDRSAAYAARWVAKSLVKA 319
>UniRef50_Q00266 Cluster: S-adenosylmethionine synthetase isoform
type-1; n=171; cellular organisms|Rep:
S-adenosylmethionine synthetase isoform type-1 - Homo
sapiens (Human)
Length = 395
Score = 137 bits (331), Expect = 3e-31
Identities = 58/88 (65%), Positives = 76/88 (86%)
Frame = +2
Query: 248 QGGLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNL 427
+ GLCRR +VQV+YAIGVAEPLSI++F YGTS KT+++LL +V KNFDLRPG IV++L+L
Sbjct: 307 KAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDL 366
Query: 428 RAPIYQRTSTYGHFGRAGFPWESPKPLL 511
+ PIYQ+T+ YGHFGR+ FPWE P+ L+
Sbjct: 367 KKPIYQKTACYGHFGRSEFPWEVPRKLV 394
Score = 118 bits (285), Expect = 9e-26
Identities = 56/84 (66%), Positives = 64/84 (76%)
Frame = +3
Query: 3 KVIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXX 182
+VI+ V+PA+YLDE TV H+ P G F+IGGPQ DAG+TGRKIIVDTY
Sbjct: 225 QVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSG 284
Query: 183 KDFTKVDRSAAYAARWVAKSLVKA 254
KD+TKVDRSAAYAARWVAKSLVKA
Sbjct: 285 KDYTKVDRSAAYAARWVAKSLVKA 308
>UniRef50_P19358 Cluster: S-adenosylmethionine synthetase 2; n=659;
cellular organisms|Rep: S-adenosylmethionine synthetase
2 - Saccharomyces cerevisiae (Baker's yeast)
Length = 384
Score = 109 bits (261), Expect = 8e-23
Identities = 47/85 (55%), Positives = 63/85 (74%)
Frame = +2
Query: 254 GLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRA 433
GLC+R VQ +YAIG+AEPLS+ V YGT+ K+ +++ I++KNFDLRPG +VKEL+L
Sbjct: 298 GLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDDEIIEIIKKNFDLRPGVLVKELDLAR 357
Query: 434 PIYQRTSTYGHFGRAGFPWESPKPL 508
PIY T++YGHF + WE PK L
Sbjct: 358 PIYLPTASYGHFTNQEYSWEKPKKL 382
Score = 103 bits (247), Expect = 4e-21
Identities = 50/83 (60%), Positives = 57/83 (68%)
Frame = +3
Query: 6 VIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXK 185
++++VIP LDE T I P G F+IGGPQ DAGLTGRKIIVD Y K
Sbjct: 215 IVEKVIPKDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGK 274
Query: 186 DFTKVDRSAAYAARWVAKSLVKA 254
D++KVDRSAAYAARWVAKSLV A
Sbjct: 275 DYSKVDRSAAYAARWVAKSLVAA 297
>UniRef50_Q2U8T6 Cluster: S-adenosylmethionine synthetase; n=2;
Ascomycota|Rep: S-adenosylmethionine synthetase -
Aspergillus oryzae
Length = 384
Score = 103 bits (246), Expect = 5e-21
Identities = 52/115 (45%), Positives = 70/115 (60%), Gaps = 6/115 (5%)
Frame = +2
Query: 185 GLHQGRPLRSIRRP---MGRQVARQ---GGLCRRCMVQVAYAIGVAEPLSITVFDYGTSH 346
G G+ R + R M R +A+ GL RC++Q++Y+IG+AEPLSI + + TS
Sbjct: 269 GAFSGKDFRQVDRSAAYMARWIAKSLVHHGLAHRCLIQLSYSIGIAEPLSIFIDTFKTSK 328
Query: 347 KTQQQLLSIVQKNFDLRPGKIVKELNLRAPIYQRTSTYGHFGRAGFPWESPKPLL 511
T QL I++KNFDLRP I K+LNL PIY +T+ GHF FPWE P L+
Sbjct: 329 FTSDQLKEIIRKNFDLRPAAIAKDLNLIDPIYYQTAKNGHFTNEKFPWEQPLDLV 383
Score = 88.2 bits (209), Expect = 2e-16
Identities = 43/82 (52%), Positives = 53/82 (64%)
Frame = +3
Query: 3 KVIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXX 182
KV+++ IPA+YLD+RT HI P G + AG+TGRKI+VDTY
Sbjct: 214 KVVRKSIPAKYLDDRTAYHIQPTGDVGVSPSGKFAGVTGRKIVVDTYGGWGAHGGGAFSG 273
Query: 183 KDFTKVDRSAAYAARWVAKSLV 248
KDF +VDRSAAY ARW+AKSLV
Sbjct: 274 KDFRQVDRSAAYMARWIAKSLV 295
>UniRef50_Q837P9 Cluster: S-adenosylmethionine synthetase; n=45;
cellular organisms|Rep: S-adenosylmethionine synthetase
- Enterococcus faecalis (Streptococcus faecalis)
Length = 394
Score = 103 bits (246), Expect = 5e-21
Identities = 51/87 (58%), Positives = 60/87 (68%)
Frame = +3
Query: 3 KVIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXX 182
+VI EVIP + LD+ T INP G F+IGGPQ DAGLTGRKIIVDTY
Sbjct: 215 QVINEVIPHELLDDETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSG 274
Query: 183 KDFTKVDRSAAYAARWVAKSLVKAACA 263
KD TKVDRSA+YAAR++AK++V A A
Sbjct: 275 KDATKVDRSASYAARYIAKNIVAAGLA 301
Score = 95.9 bits (228), Expect = 8e-19
Identities = 43/82 (52%), Positives = 61/82 (74%), Gaps = 2/82 (2%)
Frame = +2
Query: 254 GLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRA 433
GL ++ VQ+AYAIGVA+P+SI++ +GTS + +L+ V+KNFDLRP I++ L+LR
Sbjct: 299 GLAKKVEVQLAYAIGVAQPVSISINTFGTSDLPESKLIEAVRKNFDLRPAGIIEMLDLRR 358
Query: 434 PIYQRTSTYGHFGRA--GFPWE 493
PIY++T+ YGHFGR PWE
Sbjct: 359 PIYKQTAAYGHFGRTDIDLPWE 380
>UniRef50_Q9K7Q9 Cluster: S-adenosylmethionine synthetase; n=65;
cellular organisms|Rep: S-adenosylmethionine synthetase
- Bacillus halodurans
Length = 399
Score = 101 bits (241), Expect = 2e-20
Identities = 50/86 (58%), Positives = 58/86 (67%)
Frame = +3
Query: 6 VIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXK 185
VI+ V+P + +DE T INP G F+IGGPQ DAGLTGRKIIVDTY K
Sbjct: 223 VIRSVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGK 282
Query: 186 DFTKVDRSAAYAARWVAKSLVKAACA 263
D TKVDRS AYAAR+VAK++V A A
Sbjct: 283 DPTKVDRSGAYAARYVAKNIVAAGLA 308
Score = 95.9 bits (228), Expect = 8e-19
Identities = 42/82 (51%), Positives = 62/82 (75%), Gaps = 2/82 (2%)
Frame = +2
Query: 254 GLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRA 433
GL +C VQ+AYAIGVA+P+SI++ +GT ++ +L+ +V+++FDLRP I+K L+LR
Sbjct: 306 GLADKCEVQLAYAIGVAKPVSISIDTFGTGQVSEARLVELVREHFDLRPAGIIKMLDLRR 365
Query: 434 PIYQRTSTYGHFGRAG--FPWE 493
PIY++T+ YGHFGR PWE
Sbjct: 366 PIYKQTAAYGHFGRTDVELPWE 387
>UniRef50_Q7QWJ4 Cluster: S-adenosylmethionine synthetase; n=1;
Giardia lamblia ATCC 50803|Rep: S-adenosylmethionine
synthetase - Giardia lamblia ATCC 50803
Length = 436
Score = 99.1 bits (236), Expect = 8e-20
Identities = 47/88 (53%), Positives = 62/88 (70%), Gaps = 4/88 (4%)
Frame = +2
Query: 257 LCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQ---QQLLS-IVQKNFDLRPGKIVKELN 424
+C+RCMVQ+ YAIGVAEP+SI V YG+ K + QQL+ +++ F L PGKI++E
Sbjct: 346 ICKRCMVQIGYAIGVAEPVSIFVEMYGSELKPEYADQQLIERAIRRTFGLTPGKIIQEYA 405
Query: 425 LRAPIYQRTSTYGHFGRAGFPWESPKPL 508
L PI+ TS YGHFGR+ FPWE P+ L
Sbjct: 406 LDTPIFFNTSRYGHFGRSEFPWEQPRRL 433
Score = 68.5 bits (160), Expect = 1e-10
Identities = 34/66 (51%), Positives = 41/66 (62%)
Frame = +3
Query: 48 TVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYAAR 227
T + INP F+IGGP+SD GLTGRK+I D+Y KD +KVDRS AY AR
Sbjct: 274 TKLLINPSDRFVIGGPKSDCGLTGRKVIADSYGSFGSHGGGAFSGKDASKVDRSGAYLAR 333
Query: 228 WVAKSL 245
+A SL
Sbjct: 334 NIAMSL 339
>UniRef50_P0A820 Cluster: S-adenosylmethionine synthetase; n=23;
Proteobacteria|Rep: S-adenosylmethionine synthetase -
Shigella flexneri
Length = 384
Score = 96.7 bits (230), Expect = 4e-19
Identities = 47/87 (54%), Positives = 58/87 (66%)
Frame = +3
Query: 3 KVIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXX 182
++IK ++PA++L T INP G F+IGGP D GLTGRKIIVDTY
Sbjct: 206 EIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSG 265
Query: 183 KDFTKVDRSAAYAARWVAKSLVKAACA 263
KD +KVDRSAAYAAR+VAK++V A A
Sbjct: 266 KDPSKVDRSAAYAARYVAKNIVAAGLA 292
Score = 95.5 bits (227), Expect = 1e-18
Identities = 53/117 (45%), Positives = 69/117 (58%), Gaps = 3/117 (2%)
Frame = +2
Query: 152 GGARRGRFLWQGLHQGRPLRSIRRPMGRQVARQ---GGLCRRCMVQVAYAIGVAEPLSIT 322
G AR G + G + RS R VA+ GL RC +QV+YAIGVAEP SI
Sbjct: 254 GMARHGGGAFSGKDPSKVDRSAAYA-ARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIM 312
Query: 323 VFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIYQRTSTYGHFGRAGFPWE 493
V +GT +QL +V++ FDLRP +++ L+L PIY+ T+ YGHFGR FPWE
Sbjct: 313 VETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWE 369
>UniRef50_Q1GND0 Cluster: S-adenosylmethionine synthetase; n=29;
Alphaproteobacteria|Rep: S-adenosylmethionine synthetase
- Sphingopyxis alaskensis (Sphingomonas alaskensis)
Length = 406
Score = 96.3 bits (229), Expect = 6e-19
Identities = 49/86 (56%), Positives = 56/86 (65%)
Frame = +3
Query: 6 VIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXK 185
VI +V+PA+ L TV HINP G F IGGP DAGLTGRKIIVDTY K
Sbjct: 226 VIADVLPAELLTANTVYHINPTGRFEIGGPDGDAGLTGRKIIVDTYGGASPHGGGAFSGK 285
Query: 186 DFTKVDRSAAYAARWVAKSLVKAACA 263
D TKVDRSAAY R++AK++V A A
Sbjct: 286 DPTKVDRSAAYITRYLAKNIVAAGLA 311
Score = 78.2 bits (184), Expect = 2e-13
Identities = 54/140 (38%), Positives = 73/140 (52%), Gaps = 11/140 (7%)
Frame = +2
Query: 107 GPDGTQNHRGH---VWRVGGAR-RGRFLWQGLHQGRPLRS---IRRPMGRQVARQGGLCR 265
GPDG G V GGA G + G + RS I R + + + GL R
Sbjct: 254 GPDGDAGLTGRKIIVDTYGGASPHGGGAFSGKDPTKVDRSAAYITRYLAKNIVA-AGLAR 312
Query: 266 RCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIYQ 445
RC +Q++YAIGVAEPLSI V +GT + ++ +++ + L P I L L PIY+
Sbjct: 313 RCTIQLSYAIGVAEPLSIYVDLHGTGTVDEGRIEAVLPQLVRLTPKGIRTHLGLNKPIYR 372
Query: 446 RTSTYGHFGRA----GFPWE 493
+T+ YGHFGR FPWE
Sbjct: 373 QTAAYGHFGRQADGDAFPWE 392
>UniRef50_O09486 Cluster: S-adenosylmethionine synthetase; n=1;
Amoeba proteus|Rep: S-adenosylmethionine synthetase -
Amoeba proteus (Amoeba)
Length = 426
Score = 94.7 bits (225), Expect = 2e-18
Identities = 60/150 (40%), Positives = 76/150 (50%), Gaps = 7/150 (4%)
Frame = +2
Query: 80 YNWRTSVRRGPDGTQNHRGHVWRVGG-ARRGRFLWQGLHQGRPLRSIRRPMGRQVAR--- 247
Y W GT + V GG G + G + RS R VA+
Sbjct: 276 YGWTVGGPNADAGTTGRKIIVDTYGGHGAHGGGAFSGKDPSKVDRSAAY-YARYVAQNLV 334
Query: 248 QGGLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNL 427
+ LCRR +VQV+Y IG EPL+I V YGT + +LL I+ KNFD RPG I++EL+L
Sbjct: 335 RAKLCRRVLVQVSYVIGKPEPLNIYVNTYGTGTHSDSELLEIINKNFDFRPGFIIEELDL 394
Query: 428 RAP---IYQRTSTYGHFGRAGFPWESPKPL 508
P Y T+ +GHFGR FPWE K L
Sbjct: 395 LNPDRIKYVETAYHGHFGRPEFPWEQEKTL 424
>UniRef50_Q5EK82 Cluster: S-adenosyl methionine synthetase 2; n=6;
Spermatophyta|Rep: S-adenosyl methionine synthetase 2 -
Pinus taeda (Loblolly pine)
Length = 115
Score = 92.7 bits (220), Expect = 7e-18
Identities = 49/100 (49%), Positives = 65/100 (65%), Gaps = 8/100 (8%)
Frame = +2
Query: 233 RQVARQ---GGLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPG 403
RQ A+ GL RRC+VQV+YAIGV EPLSI V YGT +++L I++++FD RPG
Sbjct: 9 RQAAKSIVAAGLARRCLVQVSYAIGVPEPLSIFVDSYGTGSIPDKEILEIIKEHFDFRPG 68
Query: 404 KIVKELNLRA---PIYQRTSTYGHFGR--AGFPWESPKPL 508
I L+L+ +Q+T+ YGHFGR F WE+ KPL
Sbjct: 69 MITINLDLKRGGNGRFQKTAAYGHFGRDDPDFTWETVKPL 108
>UniRef50_Q6SZ22 Cluster: S-adenosylmethionine synthetase; n=4;
Streptococcus|Rep: S-adenosylmethionine synthetase -
Streptococcus pyogenes
Length = 353
Score = 89.8 bits (213), Expect = 5e-17
Identities = 42/91 (46%), Positives = 61/91 (67%)
Frame = +2
Query: 221 RPMGRQVARQGGLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRP 400
R + + + R+G +RC VQ+AYAIGVAEP+S+ V +GTS T QL ++++ +DL P
Sbjct: 263 RKIAKDIVREG-YAKRCEVQLAYAIGVAEPVSVYVETFGTSRYTSTQLEGMIRERYDLTP 321
Query: 401 GKIVKELNLRAPIYQRTSTYGHFGRAGFPWE 493
I+KEL+L Y +TS +GHF +A PWE
Sbjct: 322 QGIIKELHLLNVDYTKTSCFGHFTKAYLPWE 352
Score = 69.3 bits (162), Expect = 8e-11
Identities = 33/68 (48%), Positives = 43/68 (63%)
Frame = +3
Query: 60 INPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYAARWVAK 239
+NP G F++GG +DAG+TGRKI+ DTY KD +KVDRSAAY AR +AK
Sbjct: 208 VNPTGRFVLGGSFADAGVTGRKIVADTYGGFAHHGGGAFSGKDPSKVDRSAAYMARKIAK 267
Query: 240 SLVKAACA 263
+V+ A
Sbjct: 268 DIVREGYA 275
>UniRef50_A7APP7 Cluster: S-adenosylmethionine synthetase, putative;
n=1; Babesia bovis|Rep: S-adenosylmethionine synthetase,
putative - Babesia bovis
Length = 416
Score = 88.2 bits (209), Expect = 2e-16
Identities = 52/124 (41%), Positives = 68/124 (54%)
Frame = +3
Query: 6 VIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXK 185
V+K +P+++LD+ TV NP G ++ GGP D+GLTGRKI+VDTY K
Sbjct: 223 VVKPTVPSKFLDKDTVYLFNPSGKWVHGGPACDSGLTGRKIVVDTYGGWGAHGGGCFSGK 282
Query: 186 DFTKVDRSAAYAARWVAKSLVKAACAGAAWCRLLMLLV*LSHYRLQSLIMALHIRLSNNC 365
D TKVDRS AY R VAKSLV +CR ++L V S L +LHI C
Sbjct: 283 DATKVDRSGAYYCRLVAKSLV-----ANGFCRRVLLQVAYSIAVANPL--SLHINSFGTC 335
Query: 366 SPSY 377
+ +
Sbjct: 336 AEGF 339
Score = 84.2 bits (199), Expect = 2e-15
Identities = 41/84 (48%), Positives = 56/84 (66%), Gaps = 4/84 (4%)
Frame = +2
Query: 254 GLCRRCMVQVAYAIGVAEPLSITVFDYGTSHK--TQQQLLSIVQKNFDLRPGKIVKELNL 427
G CRR ++QVAY+I VA PLS+ + +GT + +L IV +NFD R G I+K+L+L
Sbjct: 306 GFCRRVLLQVAYSIAVANPLSLHINSFGTCAEGFDDNKLKEIVFRNFDFRVGCIIKQLDL 365
Query: 428 RAPIYQRTSTYGHFGRAG--FPWE 493
PI+ +TS YGHFGR G + WE
Sbjct: 366 TRPIFSKTSCYGHFGRHGDEYTWE 389
>UniRef50_P72871 Cluster: S-adenosylmethionine synthetase; n=119;
Bacteria|Rep: S-adenosylmethionine synthetase -
Synechocystis sp. (strain PCC 6803)
Length = 426
Score = 87.8 bits (208), Expect = 2e-16
Identities = 43/74 (58%), Positives = 51/74 (68%)
Frame = +3
Query: 42 ERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYA 221
++T +NP G F++GGPQ DAGLTGRKIIVDTY KD TKVDRSAAYA
Sbjct: 246 DKTRFIVNPTGKFVVGGPQGDAGLTGRKIIVDTYGGYSRHGGGAFSGKDPTKVDRSAAYA 305
Query: 222 ARWVAKSLVKAACA 263
AR+VAK++V A A
Sbjct: 306 ARYVAKNIVAAGLA 319
Score = 79.4 bits (187), Expect = 7e-14
Identities = 40/89 (44%), Positives = 54/89 (60%), Gaps = 9/89 (10%)
Frame = +2
Query: 254 GLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLR- 430
GL +C VQV+YAIGVA P+S+ + +GT +++LL +V NF+LRP I++ LNLR
Sbjct: 317 GLADKCEVQVSYAIGVARPVSVLIDTFGTGKVDEEKLLEVVLANFELRPAGIIQSLNLRN 376
Query: 431 ------APIYQRTSTYGHFGR--AGFPWE 493
YQ + YGHFGR PWE
Sbjct: 377 LPAERGGRFYQDVAAYGHFGRNDLDLPWE 405
>UniRef50_Q4A5F4 Cluster: S-adenosylmethionine synthetase; n=4;
Bacteria|Rep: S-adenosylmethionine synthetase -
Mycoplasma synoviae (strain 53)
Length = 382
Score = 86.2 bits (204), Expect = 6e-16
Identities = 45/87 (51%), Positives = 54/87 (62%)
Frame = +3
Query: 3 KVIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXX 182
+++K V+ L+ I INP G F+IGGP SD GLTGRKIIVDTY
Sbjct: 198 QILKPVLDEFNLELPERILINPTGKFVIGGPFSDTGLTGRKIIVDTYGGSARHGGGAFSG 257
Query: 183 KDFTKVDRSAAYAARWVAKSLVKAACA 263
KD TK+DRS AY ARW+AK+LV A A
Sbjct: 258 KDATKLDRSGAYMARWIAKNLVAANIA 284
Score = 82.2 bits (194), Expect = 1e-14
Identities = 47/120 (39%), Positives = 67/120 (55%), Gaps = 5/120 (4%)
Frame = +2
Query: 152 GGARRGRFLWQGLHQGRPLRSIRRPMGRQVARQ---GGLCRRCMVQVAYAIGVAEPLSIT 322
G AR G + G + RS M R +A+ + + VQ+AY+IGVA+P+S+
Sbjct: 246 GSARHGGGAFSGKDATKLDRS-GAYMARWIAKNLVAANIADKIEVQIAYSIGVAKPVSVM 304
Query: 323 VFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIYQRTSTYGHFGRAG--FPWES 496
V +G + + +L + NF+L P I+K LNL PIYQ++S YGHFGR F WES
Sbjct: 305 VNTFGENKVPEDVVLDAILNNFELTPKGIIKSLNLNKPIYQKSSVYGHFGREDFQFTWES 364
>UniRef50_Q650L4 Cluster: S-adenosylmethionine synthetase; n=19;
cellular organisms|Rep: S-adenosylmethionine synthetase
- Bacteroides fragilis
Length = 430
Score = 85.4 bits (202), Expect = 1e-15
Identities = 41/75 (54%), Positives = 49/75 (65%)
Frame = +3
Query: 39 DERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAY 218
++ + H+NP G F+IGGP D GLTGRKIIVDTY KD +KVDRSAAY
Sbjct: 242 NDHIIYHVNPTGKFVIGGPHGDTGLTGRKIIVDTYGGKGAHGGGAFSGKDPSKVDRSAAY 301
Query: 219 AARWVAKSLVKAACA 263
AAR +AK+LV A A
Sbjct: 302 AARHIAKNLVAAGVA 316
Score = 66.9 bits (156), Expect = 4e-10
Identities = 34/76 (44%), Positives = 46/76 (60%), Gaps = 2/76 (2%)
Frame = +2
Query: 254 GLCRRCMVQVAYAIGVAEPLSITVFDYGTSH--KTQQQLLSIVQKNFDLRPGKIVKELNL 427
G+ +VQV+YAIGVA P++I V YG S+ + ++ + + FDLRP I L L
Sbjct: 314 GVADEMLVQVSYAIGVARPINIYVNTYGRSNVKMSDGEIARKIDELFDLRPKAIEDRLKL 373
Query: 428 RAPIYQRTSTYGHFGR 475
R PIY T+ YGH GR
Sbjct: 374 RYPIYSETAAYGHMGR 389
>UniRef50_UPI00015BD1C2 Cluster: UPI00015BD1C2 related cluster; n=1;
unknown|Rep: UPI00015BD1C2 UniRef100 entry - unknown
Length = 372
Score = 85.0 bits (201), Expect = 1e-15
Identities = 39/92 (42%), Positives = 57/92 (61%), Gaps = 3/92 (3%)
Frame = +2
Query: 227 MGRQVARQ---GGLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLR 397
M R +A+ G ++ +VQ+AYA GV EP+ + +GT K + S +++ F L
Sbjct: 272 MARYIAKHIVAAGWAKKILVQIAYAFGVKEPIGFDIETFGTETKPIDLIKSRIREVFSLY 331
Query: 398 PGKIVKELNLRAPIYQRTSTYGHFGRAGFPWE 493
P I++ L+LR PIY+RTS YGHFG+ G PWE
Sbjct: 332 PKDIIETLDLRKPIYKRTSCYGHFGKEGLPWE 363
Score = 82.6 bits (195), Expect = 8e-15
Identities = 41/86 (47%), Positives = 53/86 (61%)
Frame = +3
Query: 6 VIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXK 185
+IK+ IP + L + T I INP G FIIGGP +D G+TGRKI+ D Y K
Sbjct: 201 IIKKHIPNELLRKETKIKINPAGRFIIGGPVADTGMTGRKIVSDAYGDISFSGGSAFSGK 260
Query: 186 DFTKVDRSAAYAARWVAKSLVKAACA 263
D TK DR+A+Y AR++AK +V A A
Sbjct: 261 DPTKTDRAASYMARYIAKHIVAAGWA 286
>UniRef50_A5BU08 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 158
Score = 83.4 bits (197), Expect = 4e-15
Identities = 37/75 (49%), Positives = 49/75 (65%)
Frame = +3
Query: 3 KVIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXX 182
+ IK +IP +YLD++T+ H+NP G F+I GP+ D GLTGRKII+DTY
Sbjct: 80 RAIKPIIPKKYLDKKTIFHLNPSGRFVIDGPRGDVGLTGRKIIIDTYKGWGGHDGGVCSG 139
Query: 183 KDFTKVDRSAAYAAR 227
KD TK+DR+ A AR
Sbjct: 140 KDPTKMDRNGACMAR 154
>UniRef50_Q661P3 Cluster: S-adenosylmethionine synthetase; n=3;
Borrelia burgdorferi group|Rep: S-adenosylmethionine
synthetase - Borrelia garinii
Length = 392
Score = 83.4 bits (197), Expect = 4e-15
Identities = 43/85 (50%), Positives = 53/85 (62%), Gaps = 1/85 (1%)
Frame = +3
Query: 3 KVIKEVIPAQ-YLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXX 179
++IK I + +DE T INP G F+IGGP D GLTGRKII D+Y
Sbjct: 214 EIIKPTIQDKSIIDENTTYCINPSGNFVIGGPTGDTGLTGRKIIADSYGGFARHGGGAYS 273
Query: 180 XKDFTKVDRSAAYAARWVAKSLVKA 254
KD TKVDRSAAY AR++AK++V A
Sbjct: 274 GKDATKVDRSAAYMARYIAKNMVAA 298
Score = 74.1 bits (174), Expect = 3e-12
Identities = 41/117 (35%), Positives = 62/117 (52%), Gaps = 3/117 (2%)
Frame = +2
Query: 152 GGARRGRFLWQGLHQGRPLRSIRRPMGRQVARQ---GGLCRRCMVQVAYAIGVAEPLSIT 322
G AR G + G + RS M R +A+ G+ + +Q+AYAIG+ P+SI
Sbjct: 263 GFARHGGGAYSGKDATKVDRSAAY-MARYIAKNMVAAGISKEFELQLAYAIGIENPISIQ 321
Query: 323 VFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIYQRTSTYGHFGRAGFPWE 493
+ K ++L+ + NFDL P I+++L L+ PIY +T TYG G+ F WE
Sbjct: 322 ITSGINDPKYANKILNFIVNNFDLTPNGIIEKLKLKQPIYLKTCTYGQLGKNEFEWE 378
>UniRef50_Q7NB16 Cluster: S-adenosylmethionine synthetase; n=2;
Mycoplasmataceae|Rep: S-adenosylmethionine synthetase -
Mycoplasma gallisepticum
Length = 395
Score = 82.2 bits (194), Expect = 1e-14
Identities = 37/68 (54%), Positives = 46/68 (67%)
Frame = +3
Query: 60 INPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYAARWVAK 239
INP GLF+ GGP +D GLTGRK++VD++ KD+TKVDRS AY ARW+AK
Sbjct: 234 INPSGLFVSGGPTADTGLTGRKLLVDSFGIYAHHGGGAYSGKDYTKVDRSGAYYARWIAK 293
Query: 240 SLVKAACA 263
+VKA A
Sbjct: 294 HIVKAKLA 301
Score = 47.6 bits (108), Expect = 3e-04
Identities = 26/75 (34%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Frame = +2
Query: 257 LCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLS-IVQKNFDLRPGKIVKELNLRA 433
L +C V +++AIG+ +PL I V + T H + L++ IV+K F+ I++ L L+
Sbjct: 300 LASQCEVIISWAIGLTKPLDIVVNCFNT-HTVELDLINQIVKKIFNHDLATIIELLKLKT 358
Query: 434 PIYQRTSTYGHFGRA 478
Y + YGHFG++
Sbjct: 359 TNYSGLAVYGHFGKS 373
>UniRef50_Q6KHY1 Cluster: S-adenosylmethionine synthetase; n=7;
Mycoplasma|Rep: S-adenosylmethionine synthetase -
Mycoplasma mobile
Length = 386
Score = 81.8 bits (193), Expect = 1e-14
Identities = 45/87 (51%), Positives = 50/87 (57%)
Frame = +3
Query: 3 KVIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXX 182
++I V L+ I IN G F IGGP D GLTGRKIIVDTY
Sbjct: 198 EIIYVVTDKYKLNRNFEILINTAGDFTIGGPIGDTGLTGRKIIVDTYGGWARHGGGAFSG 257
Query: 183 KDFTKVDRSAAYAARWVAKSLVKAACA 263
KD+TKVDRS AY ARWVAK+LV A A
Sbjct: 258 KDYTKVDRSGAYFARWVAKNLVAAEVA 284
Score = 54.0 bits (124), Expect = 3e-06
Identities = 26/68 (38%), Positives = 47/68 (69%), Gaps = 1/68 (1%)
Frame = +2
Query: 275 VQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKN-FDLRPGKIVKELNLRAPIYQRT 451
+Q A+AIG P++I + T+ K + +L+ V KN F+ G+I+++L+L+ PIY++
Sbjct: 289 IQFAFAIGKEMPIAINI--NVTNEKYKIELIEKVVKNLFNFNVGEIIEKLDLKKPIYEQV 346
Query: 452 STYGHFGR 475
+++GHFGR
Sbjct: 347 ASFGHFGR 354
>UniRef50_Q2GDS4 Cluster: S-adenosylmethionine synthetase; n=1;
Neorickettsia sennetsu str. Miyayama|Rep:
S-adenosylmethionine synthetase - Neorickettsia sennetsu
(strain Miyayama)
Length = 382
Score = 81.4 bits (192), Expect = 2e-14
Identities = 41/85 (48%), Positives = 50/85 (58%)
Frame = +3
Query: 9 IKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKD 188
I V+P + I INP G F IGGP+ D GLTGRKI+ DTY KD
Sbjct: 202 IVSVLPKDWSFSADSIIINPAGAFTIGGPKGDCGLTGRKIVADTYGGVIPNGGGAFSGKD 261
Query: 189 FTKVDRSAAYAARWVAKSLVKAACA 263
TKVDRSAAY AR++AK++V + A
Sbjct: 262 ATKVDRSAAYLARYIAKNIVFSGAA 286
Score = 60.1 bits (139), Expect = 5e-08
Identities = 29/78 (37%), Positives = 45/78 (57%)
Frame = +2
Query: 254 GLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRA 433
G +C+VQ+ YAIG+ PL++ + G + ++Q+ S++ D P I L+L
Sbjct: 284 GAASKCVVQLCYAIGMDAPLNVQISLPGITACDEEQIFSLIVDKIDFSPLGISTLLHLDR 343
Query: 434 PIYQRTSTYGHFGRAGFP 487
PIY +TST GHFG + P
Sbjct: 344 PIYLKTSTIGHFGHSYNP 361
>UniRef50_A6QA94 Cluster: S-adenosylmethionine synthetase; n=20;
Epsilonproteobacteria|Rep: S-adenosylmethionine
synthetase - Sulfurovum sp. (strain NBC37-1)
Length = 405
Score = 79.4 bits (187), Expect = 7e-14
Identities = 42/97 (43%), Positives = 59/97 (60%), Gaps = 3/97 (3%)
Frame = +3
Query: 3 KVIKEVIP--AQYLD-ERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXX 173
K+IKE + A + D ++TV +IN G ++ P +D+GLTGRK++ DTY
Sbjct: 214 KIIKEEVQFEAGHFDADKTVFYINNTGRYVTHSPIADSGLTGRKVVCDTYGGYAPIGGGA 273
Query: 174 XXXKDFTKVDRSAAYAARWVAKSLVKAACAGAAWCRL 284
KD++KVDRSA YAARW+AK +V A A A +L
Sbjct: 274 QSSKDYSKVDRSALYAARWLAKHIVAAGLAKKALVQL 310
Score = 39.5 bits (88), Expect = 0.070
Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 7/87 (8%)
Frame = +2
Query: 254 GLCRRCMVQVAYAIGVAEPLSITVFDYGT--SHKTQQQLLSIVQKNFDLRPGKIVKELNL 427
GL ++ +VQ++Y I P+S+TV T + + L ++ F L P I+ + L
Sbjct: 301 GLAKKALVQLSYVIAEPRPISVTVDTQHTALTDMKDEVLSQMIADKFVLSPKWIMHKFGL 360
Query: 428 RAP-----IYQRTSTYGHFGRAGFPWE 493
P +Y + G G +PWE
Sbjct: 361 DKPSKEHFLYAEIAAKGQIGYPEYPWE 387
>UniRef50_A6BGC6 Cluster: S-adenosylmethionine synthetase; n=1;
Dorea longicatena DSM 13814|Rep: S-adenosylmethionine
synthetase - Dorea longicatena DSM 13814
Length = 387
Score = 78.6 bits (185), Expect = 1e-13
Identities = 41/87 (47%), Positives = 53/87 (60%)
Frame = +3
Query: 3 KVIKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXX 182
KV++ + DE T I INP G F+ GG +D GLTGRK++VDTY
Sbjct: 210 KVLRSALRLLPPDEDTKILINPSGKFVCGGFDADTGLTGRKLMVDTYGSMVPHGGGAFSG 269
Query: 183 KDFTKVDRSAAYAARWVAKSLVKAACA 263
KD +KVDRSAAY AR++AK++V A A
Sbjct: 270 KDCSKVDRSAAYMARYIAKNIVAAEFA 296
Score = 70.1 bits (164), Expect = 4e-11
Identities = 36/89 (40%), Positives = 53/89 (59%), Gaps = 1/89 (1%)
Frame = +2
Query: 266 RCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSI-VQKNFDLRPGKIVKELNLRAPIY 442
+C V +AYAIGVAEP+ I V + T L+ + F + P +I++ L L PI+
Sbjct: 298 KCQVSLAYAIGVAEPVMIEVDTFDTGKVCADDCLAAAIPLVFGVTPVQIMESLRLNRPIF 357
Query: 443 QRTSTYGHFGRAGFPWESPKPLL*NDLQN 529
++T+ +GHFGR FPWE +L DLQ+
Sbjct: 358 RQTAVFGHFGRKEFPWERTDKVL--DLQD 384
>UniRef50_Q6A7D8 Cluster: S-adenosylmethionine synthetase; n=11;
Bacteria|Rep: S-adenosylmethionine synthetase -
Propionibacterium acnes
Length = 396
Score = 76.6 bits (180), Expect = 5e-13
Identities = 37/76 (48%), Positives = 49/76 (64%)
Frame = +3
Query: 36 LDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAA 215
+DE T I +NP G F+ GGP++D GLTGRK++V TY KD +KVDRSAA
Sbjct: 220 IDEHTEILVNPSGRFVEGGPRADTGLTGRKLMVGTYGGLGSHGGGAFSGKDPSKVDRSAA 279
Query: 216 YAARWVAKSLVKAACA 263
Y AR +A+++V A A
Sbjct: 280 YMARLIARTIVDAGLA 295
Score = 65.7 bits (153), Expect = 9e-10
Identities = 36/92 (39%), Positives = 47/92 (51%), Gaps = 3/92 (3%)
Frame = +2
Query: 227 MGRQVAR---QGGLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLR 397
M R +AR GL C V ++YAIG A+P++ V GT L + + F LR
Sbjct: 281 MARLIARTIVDAGLAAECEVGISYAIGKADPVAFEVDTLGTGEYADHILTAAARDVFVLR 340
Query: 398 PGKIVKELNLRAPIYQRTSTYGHFGRAGFPWE 493
P I+ LNLR P Y+ + YGH GR WE
Sbjct: 341 PAGIIDVLNLRTPRYRDLAVYGHMGRDWPRWE 372
>UniRef50_P78003 Cluster: S-adenosylmethionine synthetase; n=4;
Mycoplasma|Rep: S-adenosylmethionine synthetase -
Mycoplasma pneumoniae
Length = 383
Score = 76.6 bits (180), Expect = 5e-13
Identities = 40/88 (45%), Positives = 53/88 (60%), Gaps = 1/88 (1%)
Frame = +3
Query: 3 KVIKEVIPAQYLDERTVIH-INPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXX 179
+VI V+ L++ + H +NP G F++GGP +D GLTGRKIIVDTY
Sbjct: 201 QVILPVLTEYGLNDPKIKHLVNPGGSFVVGGPMADTGLTGRKIIVDTYGPYANHGGGSFS 260
Query: 180 XKDFTKVDRSAAYAARWVAKSLVKAACA 263
KD TKVDR+ AY AR++AK +V A
Sbjct: 261 GKDPTKVDRTGAYFARFIAKHIVSLGWA 288
Score = 45.2 bits (102), Expect = 0.001
Identities = 24/82 (29%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Frame = +2
Query: 254 GLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLS-IVQKNFDLRPGKIVKELNLR 430
G C V +++ P SI V + + + +QL++ ++ + F+ KI+ +L L
Sbjct: 286 GWAEECEVSISWVFSQPLPQSIQVKCFNINKEFSEQLINQVISQYFNWSVAKIIAKLKLL 345
Query: 431 API-YQRTSTYGHFGRAGFPWE 493
+ Y R + YGHFG PWE
Sbjct: 346 DQVEYFRYAVYGHFGHQTAPWE 367
>UniRef50_Q1VNA9 Cluster: S-adenosylmethionine synthetase; n=1;
Psychroflexus torquis ATCC 700755|Rep:
S-adenosylmethionine synthetase - Psychroflexus torquis
ATCC 700755
Length = 344
Score = 74.1 bits (174), Expect = 3e-12
Identities = 36/80 (45%), Positives = 51/80 (63%)
Frame = +3
Query: 9 IKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKD 188
+ E++ A ++++ + +NP G F+ GGP D GLTGRKI+VD Y KD
Sbjct: 180 VSEIV-ATHVNQNFQLDLNPSGSFVKGGPAGDTGLTGRKIVVDAYGPSVPVGGGAFSGKD 238
Query: 189 FTKVDRSAAYAARWVAKSLV 248
+KVDRSAAYAAR +AK++V
Sbjct: 239 PSKVDRSAAYAARHLAKNIV 258
Score = 60.5 bits (140), Expect = 4e-08
Identities = 30/79 (37%), Positives = 46/79 (58%)
Frame = +2
Query: 257 LCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAP 436
L C+V+V+YAIG AEP +TV + TS+ + + V K FD++PG I++ L+L
Sbjct: 262 LADECLVRVSYAIGKAEPYELTVNTFDTSNVKENVINDFVNK-FDMKPGAIIERLDLINV 320
Query: 437 IYQRTSTYGHFGRAGFPWE 493
Y+ + + HFG WE
Sbjct: 321 NYRIDTLFSHFGHDDRNWE 339
>UniRef50_UPI000039A2E5 Cluster: COG0192: S-adenosylmethionine
synthetase; n=1; Rickettsia rickettsii|Rep: COG0192:
S-adenosylmethionine synthetase - Rickettsia rickettsii
Length = 85
Score = 73.7 bits (173), Expect = 4e-12
Identities = 30/61 (49%), Positives = 45/61 (73%)
Frame = +2
Query: 293 IGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIYQRTSTYGHFG 472
IGVA P+S+ GTS + +Q+ ++ ++FD+RPG+I+K L LR P YQ+T++YGHFG
Sbjct: 8 IGVAAPVSVYAETCGTSTLSNEQITKLITQHFDMRPGRIIKHLKLRTPCYQQTASYGHFG 67
Query: 473 R 475
R
Sbjct: 68 R 68
>UniRef50_Q5FGR4 Cluster: S-adenosylmethionine synthetase; n=13;
Rickettsiales|Rep: S-adenosylmethionine synthetase -
Ehrlichia ruminantium (strain Gardel)
Length = 401
Score = 73.7 bits (173), Expect = 4e-12
Identities = 36/85 (42%), Positives = 51/85 (60%)
Frame = +3
Query: 9 IKEVIPAQYLDERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKD 188
+ + +P ++ + +N G F+IGGP D GLTGRKI++DTY KD
Sbjct: 212 VSKSLPKGWMCSDSNFLVNTTGRFVIGGPVGDCGLTGRKIMIDTYGGHVPHGGGAFSGKD 271
Query: 189 FTKVDRSAAYAARWVAKSLVKAACA 263
+KVDRSAAY AR++AK++V A A
Sbjct: 272 PSKVDRSAAYMARYLAKNIVSAKLA 296
Score = 71.7 bits (168), Expect = 1e-11
Identities = 44/125 (35%), Positives = 61/125 (48%), Gaps = 5/125 (4%)
Frame = +2
Query: 134 GHVWRVGGARRGRFLWQGLHQGRPLRSIRRPMGRQVARQGGLCRRCMVQVAYAIGVAEPL 313
GHV GGA G+ R + R + + + L +C+VQ++YAIG++ P
Sbjct: 258 GHVPHGGGAFSGK---DPSKVDRSAAYMARYLAKNIV-SAKLATKCLVQISYAIGISSPT 313
Query: 314 SITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIYQRTSTYGHFGR-----A 478
S V +GT ++ + N DL P I K L L PIY+ TS+YGHFGR
Sbjct: 314 SFYVNTFGTGIIDDNEIQKFIMDNIDLSPYGICKHLLLFNPIYKITSSYGHFGRIPSLNG 373
Query: 479 GFPWE 493
F WE
Sbjct: 374 SFSWE 378
>UniRef50_Q60BL6 Cluster: S-adenosylmethionine synthetase; n=6;
Bacteria|Rep: S-adenosylmethionine synthetase -
Methylococcus capsulatus
Length = 397
Score = 64.9 bits (151), Expect = 2e-09
Identities = 34/89 (38%), Positives = 48/89 (53%), Gaps = 9/89 (10%)
Frame = +2
Query: 254 GLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNL-- 427
GL C VQ++Y IG A P+S+ V +GT + + ++K+FD R G IV++ NL
Sbjct: 298 GLAEECEVQLSYTIGQARPVSVQVSTFGTGLVGEDVIKQRLEKHFDFRLGAIVRDFNLRR 357
Query: 428 -----RAPIYQRTSTYGHFGRA--GFPWE 493
R Y+R YGHFG + PWE
Sbjct: 358 LPAEYRGSFYRRLPAYGHFGASFTALPWE 386
Score = 58.0 bits (134), Expect = 2e-07
Identities = 31/75 (41%), Positives = 40/75 (53%)
Frame = +3
Query: 39 DERTVIHINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAY 218
DE T I +NP G+ GP + +G+TGRK DTY K ++DR AAY
Sbjct: 226 DEHTEIFVNPRGMLHRSGPAAHSGMTGRKSASDTYGGYARHAGSALSGKGPLRIDRVAAY 285
Query: 219 AARWVAKSLVKAACA 263
AAR AK++V A A
Sbjct: 286 AARHAAKNVVAAGLA 300
>UniRef50_Q0GGP1 Cluster: S-adenosylmethionine synthetase; n=2;
Alexandrium minutum|Rep: S-adenosylmethionine synthetase
- Alexandrium minutum
Length = 112
Score = 60.9 bits (141), Expect = 3e-08
Identities = 35/82 (42%), Positives = 45/82 (54%), Gaps = 10/82 (12%)
Frame = +2
Query: 293 IGVAEPLSITVFDYGTSHK--TQQQLLSIVQKNFDLRPGKIVKELNLRAPIYQRTSTYGH 466
IGVA+PLS+ V YGT + + + ++++ FD RPG I L LR P YQ T+ Y H
Sbjct: 5 IGVAKPLSLFVETYGTEQGALSAEDITNVIKIAFDCRPGAIAMSLALREPKYQETAAYCH 64
Query: 467 FGRAG--------FPWESPKPL 508
FGR F WES K L
Sbjct: 65 FGREAVTKDGKKFFEWESAKDL 86
>UniRef50_Q027Y1 Cluster: Methionine adenosyltransferase; n=1;
Solibacter usitatus Ellin6076|Rep: Methionine
adenosyltransferase - Solibacter usitatus (strain
Ellin6076)
Length = 364
Score = 60.5 bits (140), Expect = 4e-08
Identities = 28/69 (40%), Positives = 40/69 (57%)
Frame = +3
Query: 57 HINPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYAARWVA 236
H+N G F +GGP+ D GL+G+K++VD Y KDF K DR+ A AR +A
Sbjct: 221 HVNGAGNFEVGGPEGDNGLSGKKLVVDGYGPRVPIGGGALSGKDFFKADRAGAILARRLA 280
Query: 237 KSLVKAACA 263
K++V + A
Sbjct: 281 KAVVMSGAA 289
>UniRef50_Q2LSR0 Cluster: S-adenosylmethionine synthetase; n=1;
Syntrophus aciditrophicus SB|Rep: S-adenosylmethionine
synthetase - Syntrophus aciditrophicus (strain SB)
Length = 392
Score = 53.6 bits (123), Expect = 4e-06
Identities = 23/58 (39%), Positives = 39/58 (67%)
Frame = +2
Query: 254 GLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNL 427
GL +C +Q++YAIG+A P+SI V +GT + ++ +IV++ FDL P +++ NL
Sbjct: 300 GLAGKCSIQLSYAIGIARPISIYVHTFGTGVISDNKIGTIVREYFDLSPRGMIERFNL 357
Score = 46.8 bits (106), Expect = 5e-04
Identities = 30/83 (36%), Positives = 45/83 (54%), Gaps = 4/83 (4%)
Frame = +3
Query: 30 QYLDERTVIHINPCGLF--IIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFT--K 197
+++DE+T NP G + + +D+G+TGRK++V Y + T K
Sbjct: 221 EWVDEQTDFLFNPTGEWQSVNSCSAADSGVTGRKLVVQLYGGYPGAQLGGGSIVNKTPEK 280
Query: 198 VDRSAAYAARWVAKSLVKAACAG 266
VD SAA AR+VAK++V A AG
Sbjct: 281 VDCSAALGARYVAKNIVAAGLAG 303
>UniRef50_Q0JN66 Cluster: Os01g0323600 protein; n=1; Oryza sativa
(japonica cultivar-group)|Rep: Os01g0323600 protein -
Oryza sativa subsp. japonica (Rice)
Length = 212
Score = 52.4 bits (120), Expect = 9e-06
Identities = 32/81 (39%), Positives = 42/81 (51%)
Frame = +2
Query: 8 HQRGYPCTIS**ENCNSH*SMWTLYNWRTSVRRGPDGTQNHRGHVWRVGGARRGRFLWQG 187
HQ G+P + E+ + L + R RR P Q+H H+ R+G ARR R L QG
Sbjct: 40 HQAGHPRQVPRREDHLPPQPLGPLRHRRAPRRRRPHRPQDHHRHLRRMGRARRRRLLRQG 99
Query: 188 LHQGRPLRSIRRPMGRQVARQ 250
QGRP R + R GRQ R+
Sbjct: 100 PDQGRPERRLHRQAGRQEHRR 120
>UniRef50_Q9S992 Cluster: MET adenosyltransferase homolog; n=3; core
eudicotyledons|Rep: MET adenosyltransferase homolog -
Brassica napus (Rape)
Length = 68
Score = 45.2 bits (102), Expect = 0.001
Identities = 23/56 (41%), Positives = 35/56 (62%), Gaps = 5/56 (8%)
Frame = +2
Query: 356 QQLLSIVQKNFDLRPGKIVKELNLRA---PIYQRTSTYGHFGR--AGFPWESPKPL 508
+++L IV+++FD RPG + L+L+ + +T+ YGHFGR F WE KPL
Sbjct: 6 KEILKIVKESFDFRPGMMTINLDLKRGGNGRFLKTAAYGHFGRDDPDFTWEVVKPL 61
>UniRef50_Q42242 Cluster: S-adenosyl methionine synthase; n=5;
Eukaryota|Rep: S-adenosyl methionine synthase -
Arabidopsis thaliana (Mouse-ear cress)
Length = 56
Score = 44.0 bits (99), Expect = 0.003
Identities = 25/55 (45%), Positives = 33/55 (60%), Gaps = 5/55 (9%)
Frame = +2
Query: 377 QKNFDLRPGKIVKELNLRAP---IYQRTSTYGHFGR--AGFPWESPKPLL*NDLQ 526
+++FD RPG I L+L+ + +TS YGHFGR A F WE KPL N +Q
Sbjct: 1 KESFDFRPGMISINLDLKRGGNGRFLKTSAYGHFGRDDADFTWEVVKPLKSNKVQ 55
>UniRef50_A6PKG8 Cluster: Methionine adenosyltransferase precursor;
n=1; Victivallis vadensis ATCC BAA-548|Rep: Methionine
adenosyltransferase precursor - Victivallis vadensis
ATCC BAA-548
Length = 338
Score = 42.7 bits (96), Expect = 0.008
Identities = 25/64 (39%), Positives = 29/64 (45%)
Frame = +3
Query: 60 INPCGLFIIGGPQSDAGLTGRKIIVDTYXXXXXXXXXXXXXKDFTKVDRSAAYAARWVAK 239
+N G F+ GP D G TGRK+ VD Y KD TK D S AR A
Sbjct: 209 VNGTGRFVKHGPIGDCGTTGRKLAVDFYGGNCVIGGGSPWTKDGTKADLSLNLLARARAV 268
Query: 240 SLVK 251
S +K
Sbjct: 269 SYIK 272
>UniRef50_Q09A96 Cluster: Putative uncharacterized protein; n=1;
Stigmatella aurantiaca DW4/3-1|Rep: Putative
uncharacterized protein - Stigmatella aurantiaca DW4/3-1
Length = 596
Score = 38.7 bits (86), Expect = 0.12
Identities = 29/88 (32%), Positives = 42/88 (47%)
Frame = -1
Query: 266 AGTSRLDERLGDPSGGVCCGAVDLGEVLARESXXXXXXXXXXXVHDDFASRQARV*LRSS 87
AG +R LGD + V GAV LG VLARE V DD +R ARV ++
Sbjct: 292 AGQTRGHHVLGDVAPHVRRGAVHLGRVLAREGAAAVTAHAAVGVDDDLPARHARVAHGAT 351
Query: 86 NYKESTWINVNYSSLIKILCRDNLFDDL 3
+++ + ++ L+ L R DD+
Sbjct: 352 HHEAAGGVDEELGLLVDELGRQRPGDDV 379
>UniRef50_A2Y188 Cluster: Putative uncharacterized protein; n=1;
Oryza sativa (indica cultivar-group)|Rep: Putative
uncharacterized protein - Oryza sativa subsp. indica
(Rice)
Length = 184
Score = 36.3 bits (80), Expect = 0.65
Identities = 20/47 (42%), Positives = 24/47 (51%)
Frame = +2
Query: 116 GTQNHRGHVWRVGGARRGRFLWQGLHQGRPLRSIRRPMGRQVARQGG 256
G Q R VW+ LW+G GR RS RRPMG++ R GG
Sbjct: 73 GNQRLRARVWK--RITVAALLWKGGVVGRGRRSGRRPMGKRKVRSGG 117
>UniRef50_Q6MA58 Cluster: Putative uncharacterized protein; n=1;
Candidatus Protochlamydia amoebophila UWE25|Rep:
Putative uncharacterized protein - Protochlamydia
amoebophila (strain UWE25)
Length = 86
Score = 35.5 bits (78), Expect = 1.1
Identities = 17/48 (35%), Positives = 29/48 (60%)
Frame = +2
Query: 311 LSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKIVKELNLRAPIYQRTS 454
LS V +GT ++ +L I+ FDL +++ LNL+ P+Y++TS
Sbjct: 34 LSQKVDTFGTGTVSEAELSRIIPLIFDLTTKGVIQMLNLKRPVYRQTS 81
>UniRef50_A2VEZ2 Cluster: RT01136p; n=1; Drosophila
melanogaster|Rep: RT01136p - Drosophila melanogaster
(Fruit fly)
Length = 108
Score = 35.5 bits (78), Expect = 1.1
Identities = 21/60 (35%), Positives = 28/60 (46%)
Frame = -3
Query: 318 IDNGSATPIA*ATCTMQRRHKPP*RATWRPIGRRMLRSGRPW*SPCQRKRPRRAPPTRHT 139
+D+G+A P A AT P +WRP + R W S QR+RP +P R T
Sbjct: 1 MDSGAAAPAA-ATAAPVAVRGHPVWVSWRPPRWHTVAGARSWDSGWQRRRPGSSPSARST 59
>UniRef50_A0U6S4 Cluster: Putative uncharacterized protein
precursor; n=5; Burkholderia|Rep: Putative
uncharacterized protein precursor - Burkholderia
cenocepacia MC0-3
Length = 957
Score = 34.7 bits (76), Expect = 2.0
Identities = 20/42 (47%), Positives = 22/42 (52%)
Frame = +2
Query: 131 RGHVWRVGGARRGRFLWQGLHQGRPLRSIRRPMGRQVARQGG 256
RGH RVG RRGR +G R R RR +GR V R G
Sbjct: 325 RGHALRVGRGRRGRLRQRGQQFARG-RGDRRALGRLVGRDEG 365
>UniRef50_A3J8N0 Cluster: Signal transduction histidine kinase; n=1;
Marinobacter sp. ELB17|Rep: Signal transduction
histidine kinase - Marinobacter sp. ELB17
Length = 435
Score = 33.5 bits (73), Expect = 4.6
Identities = 18/59 (30%), Positives = 28/59 (47%)
Frame = +2
Query: 209 RSIRRPMGRQVARQGGLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKN 385
R RP+G+ V R G LCR + Y I + + +++ D S ++ L IV N
Sbjct: 293 RQHARPIGKSVVRSGALCRELFADMQYLI-ENKSIQVSMDDQAGSISIEKDLFRIVLAN 350
>UniRef50_P15557 Cluster: Acylase ACY 1 [Includes: Cephalosporin
acylase (EC 3.5.1.-) (GL-7ACA acylase);
Gamma-glutamyltranspeptidase (EC 2.3.2.2) (GGT)]
[Contains: Acylase ACY 1 large subunit; Acylase ACY 1
small subunit]; n=5; Proteobacteria|Rep: Acylase ACY 1
[Includes: Cephalosporin acylase (EC 3.5.1.-) (GL-7ACA
acylase); Gamma-glutamyltranspeptidase (EC 2.3.2.2)
(GGT)] [Contains: Acylase ACY 1 large subunit; Acylase
ACY 1 small subunit] - Pseudomonas sp. (strain SE83)
Length = 558
Score = 33.5 bits (73), Expect = 4.6
Identities = 19/64 (29%), Positives = 27/64 (42%)
Frame = +2
Query: 230 GRQVARQGGLCRRCMVQVAYAIGVAEPLSITVFDYGTSHKTQQQLLSIVQKNFDLRPGKI 409
G Q+ GG V +A+ VAEP+ + + G SH +V N PGK
Sbjct: 38 GAQILLAGGNAIDAAVASLFALTVAEPMMVGILGGGLSHIRLADGRHVVIDNLSTAPGKA 97
Query: 410 VKEL 421
E+
Sbjct: 98 TAEM 101
>UniRef50_Q12WV1 Cluster: Putative uncharacterized protein; n=1;
Methanococcoides burtonii DSM 6242|Rep: Putative
uncharacterized protein - Methanococcoides burtonii
(strain DSM 6242)
Length = 201
Score = 33.1 bits (72), Expect = 6.1
Identities = 20/56 (35%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Frame = +2
Query: 104 RGPDGTQNHRGHVWRVGGARRGRFLWQ--GLHQGRPLRSIRRPMGRQVARQGGLCR 265
+GP G QN +GG +GR G +QGR R R G V GG+C+
Sbjct: 115 QGPIGGQNQPRGQGPIGGQNQGRGQGPIGGQNQGRGQRGFRAGNGNNVVGTGGVCK 170
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 691,207,692
Number of Sequences: 1657284
Number of extensions: 14582559
Number of successful extensions: 38474
Number of sequences better than 10.0: 45
Number of HSP's better than 10.0 without gapping: 36789
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 38450
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 50000004659
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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