Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= wdS00063
(768 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P31939 Cluster: Bifunctional purine biosynthesis protei... 149 1e-34
UniRef50_Q4SHT8 Cluster: Chromosome 5 SCAF14581, whole genome sh... 103 4e-21
UniRef50_A5E8X1 Cluster: Phosphoribosylaminoimidazolecarboxamide... 87 5e-16
UniRef50_Q2JI00 Cluster: Bifunctional purine biosynthesis protei... 85 2e-15
UniRef50_Q9PC10 Cluster: Bifunctional purine biosynthesis protei... 84 3e-15
UniRef50_Q2JR47 Cluster: Bifunctional purine biosynthesis protei... 84 4e-15
UniRef50_Q73LG8 Cluster: Phosphoribosylaminoimidazolecarboxamide... 83 7e-15
UniRef50_A1K9K5 Cluster: Phosphoribosylaminoimidazolecarboxamide... 83 1e-14
UniRef50_UPI00015BCE7E Cluster: UPI00015BCE7E related cluster; n... 82 1e-14
UniRef50_A7DF55 Cluster: Phosphoribosylaminoimidazolecarboxamide... 82 1e-14
UniRef50_A7HM64 Cluster: IMP cyclohydrolase; n=1; Fervidobacteri... 81 2e-14
UniRef50_Q8ZAR3 Cluster: Bifunctional purine biosynthesis protei... 81 2e-14
UniRef50_P74741 Cluster: Bifunctional purine biosynthesis protei... 81 2e-14
UniRef50_O67775 Cluster: Bifunctional purine biosynthesis protei... 81 4e-14
UniRef50_Q550I9 Cluster: AICAR transformylase / IMP cyclohydrola... 80 7e-14
UniRef50_Q8PYG4 Cluster: Formyltransferase phosphoribosylaminoim... 79 9e-14
UniRef50_Q9FPL3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 79 1e-13
UniRef50_A2SS05 Cluster: Phosphoribosylaminoimidazolecarboxamide... 79 1e-13
UniRef50_Q7X311 Cluster: Putative AICAR transformylase; n=1; unc... 79 2e-13
UniRef50_A0JTW4 Cluster: Phosphoribosylaminoimidazolecarboxamide... 78 3e-13
UniRef50_Q9RW01 Cluster: Bifunctional purine biosynthesis protei... 77 4e-13
UniRef50_Q1V178 Cluster: Bifunctional purine biosynthesis protei... 75 3e-12
UniRef50_Q8XMK2 Cluster: Bifunctional purine biosynthesis protei... 74 5e-12
UniRef50_Q0YKD5 Cluster: IMP cyclohydrolase; n=2; Geobacter|Rep:... 73 8e-12
UniRef50_Q9F1T4 Cluster: Bifunctional purine biosynthesis protei... 73 8e-12
UniRef50_Q316G8 Cluster: Phosphoribosylaminoimidazolecarboxamide... 73 1e-11
UniRef50_A7BET6 Cluster: Putative uncharacterized protein; n=1; ... 73 1e-11
UniRef50_P67543 Cluster: Bifunctional purine biosynthesis protei... 72 1e-11
UniRef50_Q9PNY2 Cluster: Bifunctional purine biosynthesis protei... 72 1e-11
UniRef50_Q7VRP9 Cluster: Phosphoribosylaminoimidazolecarboxamide... 71 2e-11
UniRef50_Q95QQ5 Cluster: Putative uncharacterized protein; n=2; ... 71 2e-11
UniRef50_Q8CXK7 Cluster: Bifunctional purine biosynthesis protei... 71 2e-11
UniRef50_Q83EI4 Cluster: Phosphoribosylaminoimidazolecarboxamide... 71 3e-11
UniRef50_A7I7L2 Cluster: Phosphoribosylaminoimidazolecarboxamide... 71 4e-11
UniRef50_P43852 Cluster: Bifunctional purine biosynthesis protei... 71 4e-11
UniRef50_Q8G6B1 Cluster: Bifunctional purine biosynthesis protei... 69 1e-10
UniRef50_Q8F3W6 Cluster: Bifunctional purine biosynthesis protei... 69 2e-10
UniRef50_Q83GZ1 Cluster: Phosphoribosylaminoimidazolecarboxamide... 65 2e-09
UniRef50_A6G003 Cluster: Bifunctional phosphoribosylaminoimidazo... 65 2e-09
UniRef50_Q7MUT5 Cluster: Phosphoribosylaminoimidazolecarboxamide... 65 2e-09
UniRef50_Q8A155 Cluster: Bifunctional purine biosynthesis protei... 65 2e-09
UniRef50_P12048 Cluster: Bifunctional purine biosynthesis protei... 64 3e-09
UniRef50_Q6L122 Cluster: Phosphoribosylaminoimidazolecarboxamide... 62 2e-08
UniRef50_Q8D244 Cluster: Bifunctional purine biosynthesis protei... 61 3e-08
UniRef50_A1G3C3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 59 1e-07
UniRef50_Q9X0X6 Cluster: Bifunctional purine biosynthesis protei... 58 2e-07
UniRef50_Q6MIZ2 Cluster: IMP cyclohydrolase; n=1; Bdellovibrio b... 56 1e-06
UniRef50_A7PK27 Cluster: Chromosome chr15 scaffold_19, whole gen... 55 2e-06
UniRef50_A5B1A5 Cluster: DNA-directed RNA polymerase; n=1; Vitis... 55 2e-06
UniRef50_Q89B23 Cluster: Bifunctional purine biosynthesis protei... 53 7e-06
UniRef50_A4MAE3 Cluster: Phosphoribosylaminoimidazolecarboxamide... 51 3e-05
UniRef50_A1IEQ8 Cluster: IMP cyclohydrolase; n=1; Candidatus Des... 48 3e-04
UniRef50_Q3JNS9 Cluster: Putative uncharacterized protein; n=9; ... 43 0.007
UniRef50_O28464 Cluster: Inosine monophosphate cyclohydrolase; n... 43 0.007
UniRef50_A1FWI7 Cluster: Putative uncharacterized protein precur... 38 0.36
UniRef50_Q08W60 Cluster: Putative uncharacterized protein; n=1; ... 37 0.63
UniRef50_Q5FJY6 Cluster: Carbamoyl-phosphate synthase large subu... 36 0.84
UniRef50_A5B3D8 Cluster: DNA-directed RNA polymerase; n=1; Vitis... 36 1.1
UniRef50_A1HBX2 Cluster: Putative uncharacterized protein; n=2; ... 35 1.9
UniRef50_A4M1L4 Cluster: Putative uncharacterized protein; n=1; ... 35 2.6
UniRef50_Q2VZX1 Cluster: Putative uncharacterized protein; n=1; ... 34 4.5
UniRef50_Q53PF8 Cluster: Putative uncharacterized protein; n=1; ... 34 4.5
UniRef50_P77886 Cluster: Carbamoyl-phosphate synthase pyrimidine... 34 4.5
UniRef50_Q28WT5 Cluster: GA17407-PA; n=2; Coelomata|Rep: GA17407... 33 5.9
UniRef50_Q6NM73 Cluster: Cysteine-rich repeat secretory protein ... 33 5.9
UniRef50_Q1JTG1 Cluster: Putative uncharacterized protein precur... 33 7.8
>UniRef50_P31939 Cluster: Bifunctional purine biosynthesis protein
PURH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3)
(5-aminoimidazole-4-carboxamide ribonucleotide
formyltransferase) (AICAR transformylase); IMP
cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=105; cellular organisms|Rep:
Bifunctional purine biosynthesis protein PURH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3)
(5-aminoimidazole-4-carboxamide ribonucleotide
formyltransferase) (AICAR transformylase); IMP
cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Homo sapiens (Human)
Length = 592
Score = 149 bits (360), Expect = 1e-34
Identities = 68/84 (80%), Positives = 74/84 (88%)
Frame = +3
Query: 510 DLAISDYFRKQYSPGQAQLTLRYGMNPHQKPAQVFTTRDSLPITTLNGAPGFINLCDALN 689
D AISDYFRKQYS G +Q+ LRYGMNPHQ PAQ++T + LPIT LNGAPGFINLCDALN
Sbjct: 186 DEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALN 245
Query: 690 AWQLVKELKEALNLPAAASFKHVS 761
AWQLVKELKEAL +PAAASFKHVS
Sbjct: 246 AWQLVKELKEALGIPAAASFKHVS 269
Score = 105 bits (252), Expect = 1e-21
Identities = 51/81 (62%), Positives = 62/81 (76%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL+ A++L+ GL L+ASGGTA ALR+AGL V+DVS++T PEMLGGRVKTLHPAVHAG
Sbjct: 16 GLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAG 75
Query: 183 ILARLSDSDQEDMKRQKYEMI 245
ILAR D DM R + +I
Sbjct: 76 ILARNIPEDNADMARLDFNLI 96
Score = 64.9 bits (151), Expect = 2e-09
Identities = 30/48 (62%), Positives = 38/48 (79%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
AKNH RVTVVC+P DY VV E++ ++ TSL TR++LALKAFTHT+
Sbjct: 136 AKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTA 183
Score = 62.9 bits (146), Expect = 8e-09
Identities = 35/71 (49%), Positives = 44/71 (61%), Gaps = 5/71 (7%)
Frame = +2
Query: 257 CNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRAQPR-----TTTGSPSSVTRPTTML*S 421
CNLYPFV+TV+ P VTV +AVE IDIGGVTLLRA + T P +T + S
Sbjct: 101 CNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQS 160
Query: 422 KKSKRTNIIRR 454
+SK T++ R
Sbjct: 161 SESKDTSLETR 171
>UniRef50_Q4SHT8 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=3; Euteleostomi|Rep: Chromosome 5
SCAF14581, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 628
Score = 103 bits (248), Expect = 4e-21
Identities = 50/81 (61%), Positives = 61/81 (75%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL+ AK L + GL L+ASGGTA LR+AG V+DVS++T PEMLGGRVKTLHPAVH G
Sbjct: 10 GLVQFAKRLVDVGLSLVASGGTAKTLRDAGWAVRDVSELTGHPEMLGGRVKTLHPAVHGG 69
Query: 183 ILARLSDSDQEDMKRQKYEMI 245
ILAR S +D DM++ Y +I
Sbjct: 70 ILARKSPADTADMEKLGYSLI 90
Score = 103 bits (247), Expect = 5e-21
Identities = 44/62 (70%), Positives = 53/62 (85%)
Frame = +3
Query: 576 YGMNPHQKPAQVFTTRDSLPITTLNGAPGFINLCDALNAWQLVKELKEALNLPAAASFKH 755
YGMNPHQ PAQ++T R +LP+ +NG+PGFINLCDALNAWQLV+EL +AL + AA SFKH
Sbjct: 191 YGMNPHQAPAQLYTLRPALPLRVVNGSPGFINLCDALNAWQLVRELSKALGVAAATSFKH 250
Query: 756 VS 761
VS
Sbjct: 251 VS 252
Score = 64.9 bits (151), Expect = 2e-09
Identities = 30/35 (85%), Positives = 31/35 (88%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
VCNLYPFV+TVS P VTV DAVE IDIGGVTLLRA
Sbjct: 94 VCNLYPFVKTVSNPSVTVEDAVEQIDIGGVTLLRA 128
Score = 45.6 bits (103), Expect = 0.001
Identities = 28/62 (45%), Positives = 36/62 (58%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTSDLTSPYRTTSAS 540
AKNH RVTVVCDPADY V +E++ + T +R RL+ T PYRTTS
Sbjct: 130 AKNHARVTVVCDPADYPRVAEEMEGSGSRDTP--SRTRLS---------TTRPYRTTSGD 178
Query: 541 NT 546
++
Sbjct: 179 SS 180
>UniRef50_A5E8X1 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase /IMP cyclohydrolase; n=4;
Bacteria|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase /IMP cyclohydrolase - Bradyrhizobium
sp. (strain BTAi1 / ATCC BAA-1182)
Length = 530
Score = 87.0 bits (206), Expect = 5e-16
Identities = 43/75 (57%), Positives = 57/75 (76%), Gaps = 1/75 (1%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL+ A+SL+ G++LI++GGTA A+ +AGL V+DVSD+T PEM+ GRVKTLHP VH G
Sbjct: 20 GLVEFARSLAARGIELISTGGTAKAIADAGLKVKDVSDLTGFPEMMDGRVKTLHPKVHGG 79
Query: 183 ILA-RLSDSDQEDMK 224
+LA R +D E MK
Sbjct: 80 LLAIRGNDEHAEAMK 94
Score = 43.2 bits (97), Expect = 0.007
Identities = 23/68 (33%), Positives = 39/68 (57%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTSDLTSPYRTTSAS 540
+KNH+ V VV D DYD V++++ ++ T+L R+RLA KA+ T+ + A+
Sbjct: 140 SKNHEDVAVVVDVNDYDAVLEDLARHE-GSTTLLLRRRLAAKAYARTAAYDAAISNWFAA 198
Query: 541 NTRPDKPN 564
+ D P+
Sbjct: 199 TIQNDAPD 206
Score = 38.7 bits (86), Expect = 0.16
Identities = 18/35 (51%), Positives = 23/35 (65%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V NLYPF TV + +D +ENIDIGG ++RA
Sbjct: 105 VVNLYPFEATVER-SAPFSDCIENIDIGGPAMIRA 138
>UniRef50_Q2JI00 Cluster: Bifunctional purine biosynthesis protein
PurH; n=1; Synechococcus sp. JA-2-3B'a(2-13)|Rep:
Bifunctional purine biosynthesis protein PurH -
Synechococcus sp. (strain JA-2-3B'a(2-13))
(Cyanobacteria bacteriumYellowstone B-Prime)
Length = 577
Score = 84.6 bits (200), Expect = 2e-15
Identities = 46/76 (60%), Positives = 56/76 (73%), Gaps = 2/76 (2%)
Frame = +3
Query: 3 GLLSLAKSL-SECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHA 179
GL+ LA+SL E G QL++SGGTA AL AG+ V VS T APE+LGGRVKTLHP +H
Sbjct: 27 GLIPLAQSLVQEHGFQLLSSGGTAKALSEAGIPVTPVSAHTGAPEILGGRVKTLHPRIHG 86
Query: 180 GILARLSDS-DQEDMK 224
GILARL S D+ D++
Sbjct: 87 GILARLECSEDRADLE 102
Score = 43.2 bits (97), Expect = 0.007
Identities = 20/35 (57%), Positives = 25/35 (71%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V N YPF QTV++ V++ +A E IDIGG TL RA
Sbjct: 113 VVNFYPFEQTVAQAGVSLEEAFEQIDIGGPTLARA 147
>UniRef50_Q9PC10 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=214; cellular organisms|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Xylella fastidiosa
Length = 527
Score = 84.2 bits (199), Expect = 3e-15
Identities = 38/69 (55%), Positives = 51/69 (73%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL+ LA++L ++L+++GGTAT +R AGL VQDV+D+T PEM+ GRVKTLHP VH G
Sbjct: 20 GLVELARALLAYNIELLSTGGTATIIREAGLPVQDVADLTGFPEMMDGRVKTLHPMVHGG 79
Query: 183 ILARLSDSD 209
+L R D
Sbjct: 80 LLGRAGIDD 88
Score = 46.8 bits (106), Expect = 6e-04
Identities = 20/35 (57%), Positives = 26/35 (74%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
+ NLYPF Q +K D T+ADAV+ IDIGG +LR+
Sbjct: 103 ILNLYPFEQITAKKDCTLADAVDTIDIGGPAMLRS 137
>UniRef50_Q2JR47 Cluster: Bifunctional purine biosynthesis protein
PurH; n=12; Bacteria|Rep: Bifunctional purine
biosynthesis protein PurH - Synechococcus sp. (strain
JA-3-3Ab) (Cyanobacteria bacteriumYellowstone A-Prime)
Length = 537
Score = 83.8 bits (198), Expect = 4e-15
Identities = 44/76 (57%), Positives = 56/76 (73%), Gaps = 2/76 (2%)
Frame = +3
Query: 3 GLLSLAKSL-SECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHA 179
GL+ LA++L E G QL++SGGTA AL AG+ V VS+ T APE+LGGRVKTLHP +H
Sbjct: 19 GLIPLAQALVQEHGFQLLSSGGTAKALSEAGIPVTPVSEHTGAPEILGGRVKTLHPRIHG 78
Query: 180 GILARLS-DSDQEDMK 224
GILARL D+ D++
Sbjct: 79 GILARLERREDRADLE 94
Score = 43.6 bits (98), Expect = 0.006
Identities = 20/35 (57%), Positives = 25/35 (71%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V N YPF QTV++ V++ +A E IDIGG TL RA
Sbjct: 105 VVNFYPFEQTVARAGVSLEEAFEQIDIGGPTLARA 139
>UniRef50_Q73LG8 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2; Bacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Treponema
denticola
Length = 533
Score = 83.0 bits (196), Expect = 7e-15
Identities = 39/74 (52%), Positives = 51/74 (68%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL A L G IASGGTA L+ AG+ V++VS+ T +PE+LGGRVKTLHP +H G
Sbjct: 13 GLKDFAFRLKAAGYDFIASGGTAKTLQEAGIKVKEVSEYTSSPEILGGRVKTLHPMIHGG 72
Query: 183 ILARLSDSDQEDMK 224
ILAR + D+ ++K
Sbjct: 73 ILARDTKEDRAELK 86
Score = 54.8 bits (126), Expect = 2e-06
Identities = 23/35 (65%), Positives = 28/35 (80%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
+ NLYPF +T+S PD T +D +ENIDIGGV LLRA
Sbjct: 97 IANLYPFEKTISSPDSTESDCIENIDIGGVALLRA 131
Score = 54.4 bits (125), Expect = 3e-06
Identities = 27/44 (61%), Positives = 33/44 (75%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAF 492
AKN+ RVTV+CDPADYD V EI+ K + SL R+RLA+KAF
Sbjct: 133 AKNYSRVTVICDPADYDEVSSEIE--KTGEISLSLRKRLAIKAF 174
Score = 33.5 bits (73), Expect = 5.9
Identities = 29/75 (38%), Positives = 38/75 (50%), Gaps = 4/75 (5%)
Frame = +3
Query: 549 PGQAQLTLRYGMNPHQKPAQVFTTRDSL-PI--TTLNG-APGFINLCDALNAWQLVKELK 716
PGQ LRYG NPHQK A ++T P+ L G A + N+ DA AW+ V
Sbjct: 210 PGQ---DLRYGENPHQK-AWLYTNEPKAGPLGGKVLQGKALSYNNILDADAAWRAVSMFT 265
Query: 717 EALNLPAAASFKHVS 761
+ PAA KH++
Sbjct: 266 K----PAAVVVKHLT 276
>UniRef50_A1K9K5 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2; Bacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Azoarcus sp.
(strain BH72)
Length = 527
Score = 82.6 bits (195), Expect = 1e-14
Identities = 40/72 (55%), Positives = 52/72 (72%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G+L A+ L+ G++L+++GGTA LR+AGL V DVS+ T PEML GRVKTLHP VH G
Sbjct: 15 GVLDFARELAGLGIKLLSTGGTAALLRDAGLPVTDVSEHTGFPEMLDGRVKTLHPKVHGG 74
Query: 183 ILARLSDSDQED 218
ILAR ++ D
Sbjct: 75 ILARRDLAEHMD 86
Score = 56.0 bits (129), Expect = 1e-06
Identities = 28/53 (52%), Positives = 35/53 (66%), Gaps = 3/53 (5%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRAQPR---TTTGSPSSVTRP 403
V NLYPF TV++PD T+ DA+ENIDIGG T++RA + T G VT P
Sbjct: 100 VVNLYPFQATVARPDCTLEDAIENIDIGGPTMVRAAAKNHGTEAGGVGIVTDP 152
Score = 41.1 bits (92), Expect = 0.029
Identities = 25/52 (48%), Positives = 31/52 (59%), Gaps = 4/52 (7%)
Frame = +1
Query: 361 AKNHDR----VTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
AKNH V +V DP DY +V E+K N + S TR LA+KAFTHT+
Sbjct: 136 AKNHGTEAGGVGIVTDPEDYAGIVAELKANA-NTLSYKTRFALAVKAFTHTA 186
>UniRef50_UPI00015BCE7E Cluster: UPI00015BCE7E related cluster; n=1;
unknown|Rep: UPI00015BCE7E UniRef100 entry - unknown
Length = 506
Score = 82.2 bits (194), Expect = 1e-14
Identities = 41/82 (50%), Positives = 56/82 (68%), Gaps = 1/82 (1%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G+L LAK L G ++++SGGT T L+NAG+ +VS++T E+LGGRVKTLHPA+H G
Sbjct: 12 GILELAKELLNQGYEILSSGGTYTYLKNAGVDAIEVSEVTGFREILGGRVKTLHPAIHGG 71
Query: 183 ILARLS-DSDQEDMKRQKYEMI 245
IL R + D E++K E I
Sbjct: 72 ILFREDVEKDLEEIKENSIEPI 93
Score = 36.7 bits (81), Expect = 0.63
Identities = 22/48 (45%), Positives = 29/48 (60%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
AKNH RV+V+ D DY ++++K N Q R+ LALKAF TS
Sbjct: 132 AKNHKRVSVLTDIEDYGWFIEKLKMNAVSQQD---RKYLALKAFWLTS 176
>UniRef50_A7DF55 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=3;
Alphaproteobacteria|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Methylobacterium
extorquens PA1
Length = 581
Score = 82.2 bits (194), Expect = 1e-14
Identities = 37/63 (58%), Positives = 50/63 (79%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL A +LS+ G++L+++GGT AL AGL V++VS++TR PEM+ GRVKTLHPAVH G
Sbjct: 69 GLTDFAAALSQRGVELVSTGGTHRALTEAGLAVREVSELTRFPEMMDGRVKTLHPAVHGG 128
Query: 183 ILA 191
+LA
Sbjct: 129 LLA 131
Score = 42.7 bits (96), Expect = 0.010
Identities = 22/48 (45%), Positives = 32/48 (66%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
AKNH V VV D +DY ++ E+ E+ + T+ TR+RLA KAF+ T+
Sbjct: 189 AKNHADVAVVVDVSDYGAILAELAEHDGNLTAT-TRRRLAQKAFSRTA 235
Score = 37.5 bits (83), Expect = 0.36
Identities = 18/35 (51%), Positives = 23/35 (65%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V NLYPF +T+ K D VENID+GG ++RA
Sbjct: 154 VVNLYPFEETL-KAGKAYDDCVENIDVGGPAMIRA 187
>UniRef50_A7HM64 Cluster: IMP cyclohydrolase; n=1; Fervidobacterium
nodosum Rt17-B1|Rep: IMP cyclohydrolase -
Fervidobacterium nodosum Rt17-B1
Length = 429
Score = 81.4 bits (192), Expect = 2e-14
Identities = 41/82 (50%), Positives = 58/82 (70%), Gaps = 1/82 (1%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL+ AK+L + G+++I++GGTA L +AG+ V+ VSD+T PE+LGGRVKTLHP + G
Sbjct: 15 GLVEFAKNLVDRGVEIISTGGTAKLLSDAGIPVKQVSDVTGFPEILGGRVKTLHPKIFGG 74
Query: 183 ILARLSD-SDQEDMKRQKYEMI 245
ILA L D S +D++ E I
Sbjct: 75 ILADLGDKSHVKDLRDNFIEPI 96
Score = 49.6 bits (113), Expect = 8e-05
Identities = 26/47 (55%), Positives = 29/47 (61%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHT 501
AKNH V VVCDPADYD V+K I + L R+ ALKAF HT
Sbjct: 135 AKNHRNVVVVCDPADYDKVIKSI--DLCGDVQLHDRRMFALKAFYHT 179
Score = 35.1 bits (77), Expect = 1.9
Identities = 21/36 (58%), Positives = 23/36 (63%), Gaps = 1/36 (2%)
Frame = +2
Query: 254 VCNLYPFVQTVSKP-DVTVADAVENIDIGGVTLLRA 358
V NLYPF + K D V +ENIDIGGV LLRA
Sbjct: 100 VVNLYPFDEVQKKTRDEDVL--IENIDIGGVALLRA 133
>UniRef50_Q8ZAR3 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=59; Proteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Yersinia pestis
Length = 529
Score = 81.4 bits (192), Expect = 2e-14
Identities = 37/69 (53%), Positives = 50/69 (72%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G++ A++LS+ G++L+++GGTA L +AGL V +VSD T PEM+ GRVKTLHP VH G
Sbjct: 19 GIIEFAQALSQRGIELLSTGGTARLLADAGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGG 78
Query: 183 ILARLSDSD 209
IL R D
Sbjct: 79 ILGRRGQDD 87
Score = 54.8 bits (126), Expect = 2e-06
Identities = 23/35 (65%), Positives = 30/35 (85%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V NLYPF QTV++PD ++ DAVENIDIGG T++R+
Sbjct: 102 VVNLYPFAQTVARPDCSLEDAVENIDIGGPTMVRS 136
Score = 39.9 bits (89), Expect = 0.068
Identities = 19/48 (39%), Positives = 28/48 (58%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
AKNH V +V +DY ++ E+ +N + TR LA+KAF HT+
Sbjct: 138 AKNHKDVAIVVKSSDYPAIITEL-DNNDGSLTYPTRFNLAIKAFEHTA 184
>UniRef50_P74741 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=49; root|Rep: Bifunctional purine
biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Synechocystis sp. (strain PCC
6803)
Length = 511
Score = 81.4 bits (192), Expect = 2e-14
Identities = 43/76 (56%), Positives = 54/76 (71%), Gaps = 2/76 (2%)
Frame = +3
Query: 3 GLLSLAKSL-SECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHA 179
G++ LA+ L +E LI+SGGTA L+ AG+ V VSD T APE+LGGRVKTLHP +H
Sbjct: 14 GIVELAQRLVNEFQFDLISSGGTAKTLKEAGVPVTKVSDYTGAPEILGGRVKTLHPRIHG 73
Query: 180 GILARLS-DSDQEDMK 224
GILAR SDQ D++
Sbjct: 74 GILARRDLPSDQADLE 89
Score = 56.4 bits (130), Expect = 7e-07
Identities = 26/46 (56%), Positives = 34/46 (73%)
Frame = +2
Query: 221 ETSEVRDDKRGVCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
E +++R V NLYPF QT++KP VTVA+AVE IDIGG ++RA
Sbjct: 89 EANDIRPLDLVVVNLYPFEQTIAKPGVTVAEAVEQIDIGGPAMIRA 134
>UniRef50_O67775 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=9; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Aquifex aeolicus
Length = 506
Score = 80.6 bits (190), Expect = 4e-14
Identities = 38/76 (50%), Positives = 57/76 (75%), Gaps = 1/76 (1%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G+ LAK+L E G +++++GGTA LR G++V++VS+IT PE+L GRVKTLHP VH G
Sbjct: 12 GIDKLAKALQELGYEIVSTGGTAKYLREKGISVKEVSEITGFPEILEGRVKTLHPVVHGG 71
Query: 183 ILAR-LSDSDQEDMKR 227
IL R + D+E++++
Sbjct: 72 ILFRDWVEKDKEEIEK 87
Score = 41.1 bits (92), Expect = 0.029
Identities = 21/48 (43%), Positives = 31/48 (64%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
AKN RV ++ DP DYD V++++K+ +L R LA KAF+HT+
Sbjct: 132 AKNFFRVVILVDPEDYDWVIEKLKKG---NLTLQDRAYLAWKAFSHTA 176
>UniRef50_Q550I9 Cluster: AICAR transformylase / IMP cyclohydrolase;
n=2; Dictyostelium discoideum|Rep: AICAR transformylase
/ IMP cyclohydrolase - Dictyostelium discoideum AX4
Length = 542
Score = 79.8 bits (188), Expect = 7e-14
Identities = 37/64 (57%), Positives = 47/64 (73%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G++ +K LS G LI++GGTA +L + GL VQ VSD+T PEML GRVKTLHP +H G
Sbjct: 12 GIVEFSKILSSKGFNLISTGGTAKSLVDNGLKVQQVSDVTEYPEMLDGRVKTLHPKIHGG 71
Query: 183 ILAR 194
+LAR
Sbjct: 72 LLAR 75
Score = 54.4 bits (125), Expect = 3e-06
Identities = 24/38 (63%), Positives = 30/38 (78%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRAQPR 367
V NLYPFV+TVSK T+ +A+ENIDIGG TL+RA +
Sbjct: 97 VVNLYPFVETVSKESTTLEEAIENIDIGGHTLIRASSK 134
Score = 33.5 bits (73), Expect = 5.9
Identities = 18/52 (34%), Positives = 29/52 (55%), Gaps = 5/52 (9%)
Frame = +1
Query: 358 TAKNHDRVTVVCDPADYDVVVKEIKE-----NKHHQTSLGTRQRLALKAFTH 498
++KN V ++ DP+DY + + I+ N +L R++LALKAF H
Sbjct: 132 SSKNFQNVLIIVDPSDYKWIGERIQSSTDSTNVLSSITLEERKKLALKAFQH 183
>UniRef50_Q8PYG4 Cluster: Formyltransferase
phosphoribosylaminoimidazolecarboxamide; n=4;
Methanosarcinaceae|Rep: Formyltransferase
phosphoribosylaminoimidazolecarboxamide - Methanosarcina
mazei (Methanosarcina frisia)
Length = 538
Score = 79.4 bits (187), Expect = 9e-14
Identities = 36/82 (43%), Positives = 55/82 (67%), Gaps = 1/82 (1%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G++ A+ L G+++I++GGTA LR+A + V DVS++T PEM+GGRVKTLHP +H G
Sbjct: 14 GIVEFARGLEALGVKIISTGGTAKILRDADIEVTDVSEVTGYPEMMGGRVKTLHPRIHGG 73
Query: 183 ILA-RLSDSDQEDMKRQKYEMI 245
+L R S E+ ++ +I
Sbjct: 74 LLCLRESKEQMEEAAKEDISLI 95
Score = 46.8 bits (106), Expect = 6e-04
Identities = 21/33 (63%), Positives = 27/33 (81%)
Frame = +2
Query: 260 NLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
NLYPF TVS+ +V + +A+ENIDIGG TLLR+
Sbjct: 101 NLYPFEITVSRENVELEEAIENIDIGGPTLLRS 133
Score = 44.4 bits (100), Expect = 0.003
Identities = 23/49 (46%), Positives = 33/49 (67%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTSD 507
AKN+ VTV+ DP+DY ++KE++ + S TR LA+KAF HT+D
Sbjct: 135 AKNYRSVTVLSDPSDYGRILKELRSS--GIISDKTRAELAVKAFRHTAD 181
>UniRef50_Q9FPL3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=14;
Viridiplantae|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Nicotiana tabacum
(Common tobacco)
Length = 612
Score = 79.0 bits (186), Expect = 1e-13
Identities = 38/79 (48%), Positives = 53/79 (67%)
Frame = +3
Query: 6 LLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAGI 185
L L L E G ++++GGT++AL AG++V V ++TR PEML GRVKTLHP+VH GI
Sbjct: 101 LAKLGNGLQELGYTIVSTGGTSSALEGAGVSVTKVEELTRFPEMLDGRVKTLHPSVHGGI 160
Query: 186 LARLSDSDQEDMKRQKYEM 242
LAR D + +K+E+
Sbjct: 161 LAR-RDQEHHMEALEKHEI 178
Score = 38.3 bits (85), Expect = 0.21
Identities = 18/36 (50%), Positives = 23/36 (63%), Gaps = 1/36 (2%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPD-VTVADAVENIDIGGVTLLRA 358
V NLYPF VS ++ D +ENIDIGG ++RA
Sbjct: 185 VVNLYPFYAKVSSSSGISFEDGIENIDIGGPAMIRA 220
Score = 33.9 bits (74), Expect = 4.5
Identities = 28/85 (32%), Positives = 41/85 (48%), Gaps = 1/85 (1%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTSDLTSPYRTTSAS 540
AKNH V VV D DY +++ ++ + Q R++LA KAF H + S
Sbjct: 222 AKNHRDVLVVVDSEDYPALLEFLRGDNDDQQ---FRRKLAWKAFQHVASYDSAVSEWLWK 278
Query: 541 NTRPDK-PN*P*DTV*THIRNRPRF 612
T DK P P TV H+++ R+
Sbjct: 279 QTVGDKFP--PGLTVPLHLKSLLRY 301
>UniRef50_A2SS05 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=3;
Methanomicrobiales|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase -
Methanocorpusculum labreanum (strain ATCC 43576 / DSM
4855 / Z)
Length = 497
Score = 79.0 bits (186), Expect = 1e-13
Identities = 40/81 (49%), Positives = 54/81 (66%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G+L LA++L + +++SGGTA ALR AG+ +DVS+ T+ PEM+ GRVKTLHP VH G
Sbjct: 13 GILDLARALVAKNIGILSSGGTAKALREAGIPAKDVSEYTQFPEMMDGRVKTLHPKVHGG 72
Query: 183 ILARLSDSDQEDMKRQKYEMI 245
+L R D + MK E I
Sbjct: 73 LLGR-RGIDDDVMKAHFIEPI 92
Score = 33.9 bits (74), Expect = 4.5
Identities = 20/48 (41%), Positives = 29/48 (60%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
+KN+ V V+ DP+DY + ++ IK TS + RLA KAFT T+
Sbjct: 131 SKNYKDVAVLTDPSDYPMAIEAIKTGGF--TS-EQKLRLATKAFTRTA 175
Score = 33.5 bits (73), Expect = 5.9
Identities = 22/70 (31%), Positives = 31/70 (44%)
Frame = +3
Query: 504 GLDLAISDYFRKQYSPGQAQLTLRYGMNPHQKPAQVFTTRDSLPITTLNGAPGFINLCDA 683
G+D D + Q+ G+ LRYG NPHQK A T+ + + + N D
Sbjct: 187 GIDKEFPDVYTMQFGNGRK---LRYGENPHQKAAVYGTSGIAGQVALQGKEMSYNNYLDV 243
Query: 684 LNAWQLVKEL 713
A L +EL
Sbjct: 244 HAAVSLCREL 253
>UniRef50_Q7X311 Cluster: Putative AICAR transformylase; n=1;
uncultured Acidobacteria bacterium|Rep: Putative AICAR
transformylase - uncultured Acidobacteria bacterium
Length = 571
Score = 78.6 bits (185), Expect = 2e-13
Identities = 37/82 (45%), Positives = 53/82 (64%), Gaps = 1/82 (1%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G++ A L ++++++GGTA LR AG+ V+DVSD+T PEM+ GRVKTLHP +H G
Sbjct: 24 GIVDFASELRAFDIEIVSTGGTAKTLREAGIEVRDVSDVTGFPEMMDGRVKTLHPKIHGG 83
Query: 183 IL-ARLSDSDQEDMKRQKYEMI 245
+L R S S + M+ E I
Sbjct: 84 LLGVRDSPSHESSMREHGIEPI 105
Score = 39.5 bits (88), Expect = 0.090
Identities = 16/35 (45%), Positives = 26/35 (74%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V +LYPF +T+ V++A+A+E IDIGG ++R+
Sbjct: 109 VIDLYPFERTIKGAAVSLAEAIEQIDIGGPAMIRS 143
>UniRef50_A0JTW4 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=2;
Arthrobacter|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Arthrobacter sp.
(strain FB24)
Length = 559
Score = 77.8 bits (183), Expect = 3e-13
Identities = 35/63 (55%), Positives = 47/63 (74%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL LAK L E G++++++G TA + AG+ VQ+V ++T +PEML GRVKTLHP VH G
Sbjct: 23 GLEELAKGLHEAGVKIVSTGSTAKKIAAAGIPVQEVEEVTGSPEMLDGRVKTLHPRVHGG 82
Query: 183 ILA 191
ILA
Sbjct: 83 ILA 85
Score = 44.8 bits (101), Expect = 0.002
Identities = 27/60 (45%), Positives = 32/60 (53%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTSDLTSPYRTTSAS 540
AKNH V +V DP Y VV+ E L TRQRLA KAF HT+ + T +AS
Sbjct: 143 AKNHAAVAIVTDPNFYGDVVRAAAEGGF---DLKTRQRLAAKAFAHTASYDTAVATWTAS 199
Score = 37.9 bits (84), Expect = 0.27
Identities = 19/35 (54%), Positives = 23/35 (65%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V NLYPFV+TV K D VE IDIGG ++R+
Sbjct: 108 VVNLYPFVETV-KSGAAQDDVVEQIDIGGPAMVRS 141
>UniRef50_Q9RW01 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=3; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Deinococcus radiodurans
Length = 510
Score = 77.4 bits (182), Expect = 4e-13
Identities = 35/64 (54%), Positives = 46/64 (71%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G++ A L + G +L+++GGT L AG+ V+ VSD+T PEML GRVKTLHPA+H G
Sbjct: 14 GVVEFAAQLQQRGWELLSTGGTFATLSGAGIPVRQVSDVTGFPEMLDGRVKTLHPAIHGG 73
Query: 183 ILAR 194
ILAR
Sbjct: 74 ILAR 77
Score = 42.3 bits (95), Expect = 0.013
Identities = 22/49 (44%), Positives = 31/49 (63%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTSD 507
AKNHD V V+ DPADY + +++ + S R+RLA KA+ HTS+
Sbjct: 133 AKNHDAVLVLVDPADYALALQD-------EVSPAERRRLAAKAYRHTSE 174
Score = 35.1 bits (77), Expect = 1.9
Identities = 20/38 (52%), Positives = 27/38 (71%), Gaps = 3/38 (7%)
Frame = +2
Query: 254 VC-NLYPFVQTVSK--PDVTVADAVENIDIGGVTLLRA 358
VC NLYPF +TV++ PD V +ENIDIGG ++R+
Sbjct: 97 VCVNLYPFRETVARGAPDPEV---IENIDIGGPAMIRS 131
>UniRef50_Q1V178 Cluster: Bifunctional purine biosynthesis protein;
n=2; Candidatus Pelagibacter ubique|Rep: Bifunctional
purine biosynthesis protein - Candidatus Pelagibacter
ubique HTCC1002
Length = 518
Score = 74.5 bits (175), Expect = 3e-12
Identities = 64/246 (26%), Positives = 107/246 (43%), Gaps = 12/246 (4%)
Frame = +3
Query: 12 SLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAGILA 191
SL + L++ ++LI+SGGT ++ Q+VS+ T +PE+LGGRVKTLHP +HAGIL+
Sbjct: 26 SLLRVLAKYKIELISSGGTFKEIKKLKFKCQEVSEYTGSPEILGGRVKTLHPKIHAGILS 85
Query: 192 RLSD-SDQEDMKRQKYEMIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAA*PSCAHSQE 368
+ +D S +++K +Y+ I A ++
Sbjct: 86 KRNDKSHTKELKANQYDEIDLVIVNFYPFEKTLDQTTNHSKIIENIDVGGPTMVRAAAKN 145
Query: 369 XXXXXXXXXXXXXXCCSQRNQREQTSSDV-FGHKAEISPEGVHSYFGLDLAISDYF---- 533
+ + S+ + F K + +Y+ D IS+YF
Sbjct: 146 YNDVTVITSSDQYETLINELENNKGSTSIEFREKMSLEAFSETAYY--DAVISNYFNKIK 203
Query: 534 -----RKQYSPGQAQLTLRYGMNPHQKPAQVFTTRDSLPITTLNGAP-GFINLCDALNAW 695
+K+ G LRYG NPHQ+ A +++ +L I ++G + N D +A
Sbjct: 204 KNNFPKKKIIYGNLIEKLRYGENPHQE-AAIYSKTQNLNIKQIHGKQLSYNNYNDIFSAL 262
Query: 696 QLVKEL 713
+ K L
Sbjct: 263 TISKSL 268
Score = 39.5 bits (88), Expect = 0.090
Identities = 17/48 (35%), Positives = 33/48 (68%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
AKN++ VTV+ Y+ ++ E++ NK TS+ R++++L+AF+ T+
Sbjct: 143 AKNYNDVTVITSSDQYETLINELENNK-GSTSIEFREKMSLEAFSETA 189
Score = 33.1 bits (72), Expect = 7.8
Identities = 14/35 (40%), Positives = 23/35 (65%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
+ N YPF +T+ + + +ENID+GG T++RA
Sbjct: 108 IVNFYPFEKTLDQT-TNHSKIIENIDVGGPTMVRA 141
>UniRef50_Q8XMK2 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=14; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Clostridium perfringens
Length = 501
Score = 73.7 bits (173), Expect = 5e-12
Identities = 39/74 (52%), Positives = 54/74 (72%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G+L LAK L + +++I+SGGT L+ + V+++S+IT PEML GRVKTLHP VHAG
Sbjct: 14 GVLELAKFLRDRDVEIISSGGTYKYLKENNIEVKEISEITDFPEMLDGRVKTLHPLVHAG 73
Query: 183 ILARLSDSDQEDMK 224
ILA + D ++E MK
Sbjct: 74 ILA-IRD-NKEHMK 85
Score = 38.3 bits (85), Expect = 0.21
Identities = 21/46 (45%), Positives = 28/46 (60%)
Frame = +2
Query: 221 ETSEVRDDKRGVCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
E E+ V NLYPF + V + D++ + VE IDIGG T+LRA
Sbjct: 88 EEREINTIDYVVVNLYPFFEKV-REDLSFEEKVEFIDIGGPTMLRA 132
Score = 33.1 bits (72), Expect = 7.8
Identities = 20/44 (45%), Positives = 25/44 (56%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAF 492
AKN V V+ D DY+ V+ EIKEN + S R+ LA K F
Sbjct: 134 AKNFKDVVVLSDKKDYEKVMNEIKEN--NCVSFKLRKTLAGKVF 175
>UniRef50_Q0YKD5 Cluster: IMP cyclohydrolase; n=2; Geobacter|Rep:
IMP cyclohydrolase - Geobacter sp. FRC-32
Length = 388
Score = 72.9 bits (171), Expect = 8e-12
Identities = 34/67 (50%), Positives = 43/67 (64%)
Frame = +3
Query: 561 QLTLRYGMNPHQKPAQVFTTRDSLPITTLNGAPGFINLCDALNAWQLVKELKEALNLPAA 740
++ L+YG N HQ PA + +S LNG P +IN+ DAL AWQL +ELK A + P A
Sbjct: 2 EIKLKYGCNSHQTPANLIIPENS-GFQVLNGTPSYINILDALGAWQLARELKIATSKPGA 60
Query: 741 ASFKHVS 761
ASFKH S
Sbjct: 61 ASFKHTS 67
>UniRef50_Q9F1T4 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=57; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Streptococcus suis
Length = 515
Score = 72.9 bits (171), Expect = 8e-12
Identities = 31/64 (48%), Positives = 46/64 (71%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G++ A+ L++ G ++I++GGT AL AG+T + D+T PEM+ GRVKTLHP +H G
Sbjct: 14 GIVEFAQELTKFGWEIISTGGTKVALDQAGVTTIAIDDVTGFPEMMDGRVKTLHPKIHGG 73
Query: 183 ILAR 194
+LAR
Sbjct: 74 LLAR 77
Score = 58.8 bits (136), Expect = 1e-07
Identities = 34/69 (49%), Positives = 40/69 (57%), Gaps = 3/69 (4%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS---DLTSPYRTT 531
AKNH VTVV DPADY V+ EI E +TS TRQRLA K F HT+ L + Y T
Sbjct: 135 AKNHASVTVVVDPADYPTVLGEIAE--QGETSYATRQRLAAKVFRHTAAYDALIADYFTK 192
Query: 532 SASNTRPDK 558
+P+K
Sbjct: 193 QVGEDKPEK 201
Score = 49.2 bits (112), Expect = 1e-04
Identities = 22/35 (62%), Positives = 28/35 (80%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V NLYPF +T+ +PDVT AVENIDIGG ++LR+
Sbjct: 99 VVNLYPFKETILRPDVTYDLAVENIDIGGPSMLRS 133
>UniRef50_Q316G8 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=4; Desulfovibrionaceae|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Desulfovibrio desulfuricans (strain
G20)
Length = 252
Score = 72.5 bits (170), Expect = 1e-11
Identities = 33/63 (52%), Positives = 45/63 (71%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL+ A L++ G++L+++GGT L AGL V VS +T PE++GGRVKTLHP +H G
Sbjct: 71 GLVEFATFLTQNGVELVSTGGTQRTLTEAGLDVTPVSKVTGFPEIMGGRVKTLHPHIHGG 130
Query: 183 ILA 191
ILA
Sbjct: 131 ILA 133
Score = 40.3 bits (90), Expect = 0.051
Identities = 20/49 (40%), Positives = 30/49 (61%)
Frame = +1
Query: 358 TAKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
TAKN + V+ DPADY ++E+++N + L RQ +A+K F TS
Sbjct: 190 TAKNFHSMLVLPDPADYQAAMQEMRDN-DMRVGLAMRQAMAVKTFRATS 237
>UniRef50_A7BET6 Cluster: Putative uncharacterized protein; n=1;
Actinomyces odontolyticus ATCC 17982|Rep: Putative
uncharacterized protein - Actinomyces odontolyticus ATCC
17982
Length = 614
Score = 72.5 bits (170), Expect = 1e-11
Identities = 32/63 (50%), Positives = 46/63 (73%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL LA++L E G++++++G TA + AG+ V V D+T PE+L GRVKTLHP +H+G
Sbjct: 28 GLEDLARALGEAGVEIVSTGSTAARIAAAGVAVTPVDDVTGFPEVLEGRVKTLHPFIHSG 87
Query: 183 ILA 191
ILA
Sbjct: 88 ILA 90
Score = 39.1 bits (87), Expect = 0.12
Identities = 22/50 (44%), Positives = 30/50 (60%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRAQPRTTTGSPSSVTRP 403
VCNLYPF TV+ + + VE IDIGG +++RA + S + VT P
Sbjct: 113 VCNLYPFQDTVAS-GASFDECVEQIDIGGPSMVRAAAKNHP-SVAVVTSP 160
>UniRef50_P67543 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=18; Staphylococcus|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Staphylococcus aureus (strain Mu50
/ ATCC 700699)
Length = 492
Score = 72.1 bits (169), Expect = 1e-11
Identities = 35/82 (42%), Positives = 52/82 (63%), Gaps = 1/82 (1%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G++ AK+L++ +L ++GGT L A + V+ VSD+T PE++ GRVKTLHPAVH G
Sbjct: 13 GIVEFAKALTQLNYELYSTGGTKRILDEANVPVRSVSDLTHFPEIMDGRVKTLHPAVHGG 72
Query: 183 ILA-RLSDSDQEDMKRQKYEMI 245
ILA R ++ Q ++I
Sbjct: 73 ILADRNKPQHLNELSEQHIDLI 94
Score = 56.8 bits (131), Expect = 6e-07
Identities = 25/35 (71%), Positives = 30/35 (85%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V NLYPF QTV+ PDVT+ +A+ENIDIGG T+LRA
Sbjct: 98 VVNLYPFQQTVANPDVTMDEAIENIDIGGPTMLRA 132
Score = 35.5 bits (78), Expect = 1.5
Identities = 17/49 (34%), Positives = 28/49 (57%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTSD 507
AKN+ VT + PADY V+ ++ + ++ RQ L +K F HT++
Sbjct: 134 AKNYKHVTTIVHPADYHEVLTRLRNDSLDES---YRQSLMIKVFEHTAE 179
>UniRef50_Q9PNY2 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=21; Epsilonproteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Campylobacter jejuni
Length = 510
Score = 72.1 bits (169), Expect = 1e-11
Identities = 30/69 (43%), Positives = 46/69 (66%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G++ K L G +++++GGT L+ G+ V +VSD T++PE+ GRVKTLHP +H G
Sbjct: 12 GIVEFGKELENLGFEILSTGGTFKLLKENGIKVIEVSDFTKSPELFEGRVKTLHPKIHGG 71
Query: 183 ILARLSDSD 209
IL + SD +
Sbjct: 72 ILHKRSDEN 80
Score = 40.7 bits (91), Expect = 0.039
Identities = 18/49 (36%), Positives = 32/49 (65%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTSD 507
AKN+ V V+CDP DY+ V++ +K+ ++ + R L +KA+ HT++
Sbjct: 132 AKNYKDVMVLCDPLDYEKVIETLKKGQNDE---NFRLNLMIKAYEHTAN 177
Score = 34.7 bits (76), Expect = 2.6
Identities = 26/69 (37%), Positives = 28/69 (40%), Gaps = 1/69 (1%)
Frame = +3
Query: 552 GQAQLTLRYGMNPHQKPA-QVFTTRDSLPITTLNGAPGFINLCDALNAWQLVKELKEALN 728
GQ +YG NPHQK A F S L G F NL D A L +A
Sbjct: 202 GQKVFDTKYGENPHQKGALYEFDAFFSANFKALKGEASFNNLTDINAALNLASSFDKA-- 259
Query: 729 LPAAASFKH 755
PA A KH
Sbjct: 260 -PAIAIVKH 267
Score = 33.1 bits (72), Expect = 7.8
Identities = 17/36 (47%), Positives = 23/36 (63%), Gaps = 1/36 (2%)
Frame = +2
Query: 254 VC-NLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
VC NLYPF +T D + +ENIDIGG ++R+
Sbjct: 96 VCVNLYPFKKTTIMSD-DFDEIIENIDIGGPAMIRS 130
>UniRef50_Q7VRP9 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase, IMP cyclohydrolase and MGS-like
domain; n=2; Candidatus Blochmannia|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase, IMP cyclohydrolase and MGS-like
domain - Blochmannia floridanus
Length = 549
Score = 71.3 bits (167), Expect = 2e-11
Identities = 34/63 (53%), Positives = 46/63 (73%)
Frame = +3
Query: 6 LLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAGI 185
LL +KSLS G++L+++ GTA L NAGLTV +SD T PE++ G+VKTLH + AGI
Sbjct: 20 LLHFSKSLSHLGIKLLSTEGTALILTNAGLTVNKISDYTNFPEIMNGQVKTLHHKICAGI 79
Query: 186 LAR 194
L+R
Sbjct: 80 LSR 82
Score = 37.5 bits (83), Expect = 0.36
Identities = 19/46 (41%), Positives = 25/46 (54%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTH 498
AKN+ ++ D DYD ++ EI H SL TR LA KAF +
Sbjct: 138 AKNYKNTVIIVDNNDYDNILNEI-NTLHGSISLNTRLNLAAKAFKY 182
>UniRef50_Q95QQ5 Cluster: Putative uncharacterized protein; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 420
Score = 71.3 bits (167), Expect = 2e-11
Identities = 30/44 (68%), Positives = 36/44 (81%)
Frame = +3
Query: 630 LPITTLNGAPGFINLCDALNAWQLVKELKEALNLPAAASFKHVS 761
+PI LNG+PG+IN+ D LN WQLVKEL +A +PAAASFKHVS
Sbjct: 1 MPIKVLNGSPGYINILDGLNGWQLVKELSDATKMPAAASFKHVS 44
>UniRef50_Q8CXK7 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=34; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Oceanobacillus iheyensis
Length = 510
Score = 71.3 bits (167), Expect = 2e-11
Identities = 29/68 (42%), Positives = 46/68 (67%)
Frame = +3
Query: 6 LLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAGI 185
++ AK L E G +++++GGT ++ AG+ V V ++T PEML GRVKTLHP +H G+
Sbjct: 15 IIEFAKGLKESGFEILSTGGTLRSIAEAGIDVTPVDEVTGFPEMLDGRVKTLHPMIHGGL 74
Query: 186 LARLSDSD 209
L + S+ +
Sbjct: 75 LGKRSNHE 82
Score = 50.0 bits (114), Expect = 6e-05
Identities = 21/33 (63%), Positives = 27/33 (81%)
Frame = +2
Query: 260 NLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
NLYPF +TV KPDV+ D +ENIDIGG ++LR+
Sbjct: 101 NLYPFKETVQKPDVSHQDIIENIDIGGPSMLRS 133
Score = 35.9 bits (79), Expect = 1.1
Identities = 35/115 (30%), Positives = 53/115 (46%), Gaps = 5/115 (4%)
Frame = +3
Query: 432 REQTSSDVFGHKAEISPEGVHSYFGLDLAISDYFRKQYSPGQAQLTLRYGMNPHQKPA-- 605
R+Q ++ VF H A + +YF L Y + LRYG NPHQ+ A
Sbjct: 167 RQQLAAKVFRHTASYDAM-IANYF-LSQTEEQYPESYTVTYEKVQDLRYGENPHQQAAFY 224
Query: 606 -QVFTTRDSLPIT-TLNGAP-GFINLCDALNAWQLVKELKEALNLPAAASFKHVS 761
+ +R +L L+G + N+ D A ++VKE E PAA + KH++
Sbjct: 225 KEPIQSRPTLATAKQLHGKELSYNNIQDTNAAIEIVKEFAE----PAAVAVKHMN 275
>UniRef50_Q83EI4 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=5; Coxiella
burnetii|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Coxiella burnetii
Length = 526
Score = 70.9 bits (166), Expect = 3e-11
Identities = 33/64 (51%), Positives = 43/64 (67%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL+ L CG+++IA+GGTA L+ L V DV T PE++ GRVKTLHP +HAG
Sbjct: 23 GLIEFISQLVTCGVEIIATGGTAELLKQHQLPVIDVFTYTGFPEIMDGRVKTLHPKIHAG 82
Query: 183 ILAR 194
+LAR
Sbjct: 83 LLAR 86
Score = 50.8 bits (116), Expect = 4e-05
Identities = 26/48 (54%), Positives = 32/48 (66%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
AKN VTVV DP DY +++EIK + H T+L TR+RLA K F H S
Sbjct: 142 AKNFAAVTVVVDPEDYSRILEEIKTH-HGSTTLSTRKRLAQKTFEHLS 188
Score = 46.8 bits (106), Expect = 6e-04
Identities = 22/35 (62%), Positives = 27/35 (77%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V NLYPFVQTVS + ++ AVE IDIGG ++LRA
Sbjct: 106 VVNLYPFVQTVSASNCSLEKAVEQIDIGGPSMLRA 140
>UniRef50_A7I7L2 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=1; Candidatus
Methanoregula boonei 6A8|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Methanoregula
boonei (strain 6A8)
Length = 525
Score = 70.5 bits (165), Expect = 4e-11
Identities = 33/69 (47%), Positives = 45/69 (65%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G++ LA++L + +++SGGT TAL AG+ +VS T PEM+ GRVKTLHP VH G
Sbjct: 43 GIVDLAQALIQHNFSIMSSGGTGTALAGAGIPFTEVSRYTGFPEMMDGRVKTLHPKVHGG 102
Query: 183 ILARLSDSD 209
+L R D
Sbjct: 103 LLGRRQIDD 111
Score = 33.5 bits (73), Expect = 5.9
Identities = 26/68 (38%), Positives = 31/68 (45%), Gaps = 4/68 (5%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRL--ALKAFTHTS--DLTSPYRT 528
AKN V VV DP+DY VVK + N QRL A KAF T+ D
Sbjct: 161 AKNFKDVAVVVDPSDYPEVVKTLSSN----VGFSHEQRLIFAKKAFARTAAYDAAISNHL 216
Query: 529 TSASNTRP 552
++ NT P
Sbjct: 217 SNLDNTFP 224
>UniRef50_P43852 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=88; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Haemophilus influenzae
Length = 532
Score = 70.5 bits (165), Expect = 4e-11
Identities = 34/69 (49%), Positives = 45/69 (65%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G++ A+ L + G++L+++GGTA L L V +VSD T PEM+ GRVKTLHP VH G
Sbjct: 18 GIVEFAQGLVKRGVKLLSTGGTAKLLAQNALPVIEVSDYTGFPEMMDGRVKTLHPKVHGG 77
Query: 183 ILARLSDSD 209
IL R D
Sbjct: 78 ILGRRGTDD 86
Score = 57.2 bits (132), Expect = 4e-07
Identities = 25/35 (71%), Positives = 30/35 (85%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V NLYPF TV+KPD T+ADAVENIDIGG T++R+
Sbjct: 101 VVNLYPFAATVAKPDCTLADAVENIDIGGPTMVRS 135
Score = 37.9 bits (84), Expect = 0.27
Identities = 19/52 (36%), Positives = 32/52 (61%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTSDLTS 516
AKNH V +V + D++ ++ E+ ++++ T TR LA+KAF HT+ S
Sbjct: 137 AKNHKDVAIVVNNHDFNAILAEMDQHQNSLT-FETRFDLAIKAFEHTAQYDS 187
>UniRef50_Q8G6B1 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=89; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bifidobacterium longum
Length = 545
Score = 68.9 bits (161), Expect = 1e-10
Identities = 31/69 (44%), Positives = 48/69 (69%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G+ LA++ + G +++++G TA L G+ V +VSD+T PE L GRVKTLHP +HAG
Sbjct: 20 GIEVLAEAFVKAGTEVVSTGSTAKKLAELGVKVTEVSDVTGFPECLDGRVKTLHPYIHAG 79
Query: 183 ILARLSDSD 209
ILA +++ +
Sbjct: 80 ILADMTNPE 88
Score = 42.3 bits (95), Expect = 0.013
Identities = 22/48 (45%), Positives = 28/48 (58%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
AKNH V +V DPADY +V + + SL R+ LA KAF HT+
Sbjct: 140 AKNHATVAIVTDPADYALVASRVADGTGF--SLDERKWLAAKAFAHTA 185
Score = 36.3 bits (80), Expect = 0.84
Identities = 17/34 (50%), Positives = 22/34 (64%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLR 355
V NLYPF TV + AD +E IDIGG +++R
Sbjct: 105 VVNLYPFADTV-RSGANEADTIEKIDIGGPSMVR 137
>UniRef50_Q8F3W6 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=6; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Leptospira interrogans
Length = 511
Score = 68.5 bits (160), Expect = 2e-10
Identities = 33/85 (38%), Positives = 54/85 (63%), Gaps = 4/85 (4%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL+ AK L++ G+++I++GGT L++ G+ + D T PE+L GRVKTLHP VH G
Sbjct: 16 GLVEFAKFLNQNGVEIISTGGTLKLLKDNGIAAIAIDDYTGFPEILDGRVKTLHPKVHGG 75
Query: 183 ILARLSD----SDQEDMKRQKYEMI 245
+L +S+ E++K K +++
Sbjct: 76 LLGVISNPAHKQKMEELKIPKIDLV 100
Score = 52.4 bits (120), Expect = 1e-05
Identities = 21/35 (60%), Positives = 31/35 (88%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V NLYPF++TVSKP+V + +A+ENIDIGG +++R+
Sbjct: 101 VVNLYPFLKTVSKPEVQLEEAIENIDIGGPSMIRS 135
>UniRef50_Q83GZ1 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=2; Tropheryma whipplei|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 542
Score = 65.3 bits (152), Expect = 2e-09
Identities = 29/63 (46%), Positives = 45/63 (71%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL LA++L+ ++++++G TA +R + V+DVS++T E+L GRVKTLHP +HA
Sbjct: 19 GLADLAEALAAHSVKIVSTGSTAEFIRGVSIPVRDVSEVTGVGELLDGRVKTLHPKIHAP 78
Query: 183 ILA 191
ILA
Sbjct: 79 ILA 81
Score = 42.3 bits (95), Expect = 0.013
Identities = 20/49 (40%), Positives = 31/49 (63%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTSD 507
AKNH RV V+ DP+DY V+ ++ + R +LA+KA++HTS+
Sbjct: 140 AKNHTRVVVIVDPSDYIHVINSLERGAPSR----LRHQLAIKAYSHTSE 184
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/41 (41%), Positives = 23/41 (56%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRAQPRTTT 376
V NLYPF + + +D +E IDIGG L+RA + T
Sbjct: 104 VVNLYPFFEISKNSEAEFSDVIEQIDIGGSALIRAAAKNHT 144
>UniRef50_A6G003 Cluster: Bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=1; Plesiocystis
pacifica SIR-1|Rep: Bifunctional
phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Plesiocystis
pacifica SIR-1
Length = 543
Score = 65.3 bits (152), Expect = 2e-09
Identities = 31/70 (44%), Positives = 48/70 (68%)
Frame = +3
Query: 15 LAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAGILAR 194
LA+ L ++++++GGT AL G+ V VS+ T APE+L GRVKTLHP +H GILA
Sbjct: 30 LAEILIAHKVEVLSTGGTYRALSELGVAVVKVSEFTGAPEILDGRVKTLHPKIHGGILAL 89
Query: 195 LSDSDQEDMK 224
+++ Q +++
Sbjct: 90 PTEAHQRELE 99
Score = 52.0 bits (119), Expect = 2e-05
Identities = 21/35 (60%), Positives = 29/35 (82%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
+ NLYPF +T++KP + ADA+ENIDIGG T++RA
Sbjct: 110 IVNLYPFRETIAKPGCSFADAIENIDIGGPTMVRA 144
Score = 36.3 bits (80), Expect = 0.84
Identities = 30/79 (37%), Positives = 40/79 (50%), Gaps = 9/79 (11%)
Frame = +3
Query: 552 GQAQLTLRYGMNPHQKPAQVFTTRDSLPITTLN-------GAPGFINLCDALNAWQLVKE 710
G++ LRYG NPHQ+ T+ S T L+ A + NL DA A L+++
Sbjct: 225 GESVAELRYGENPHQQARFFATSYASDEATGLDQAIVHQGKALSYNNLLDADAALGLIRD 284
Query: 711 LKEAL--NLPAAASFKHVS 761
LK L AAA FKH+S
Sbjct: 285 LKAGLPEGGKAAAVFKHLS 303
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/48 (37%), Positives = 27/48 (56%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
AKN +RV V+ DP DY + + + E + R+ +A KAF HT+
Sbjct: 146 AKNWNRVAVIVDPEDYSSLSEVLGETEGTLPE-SFRRNMARKAFAHTA 192
>UniRef50_Q7MUT5 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase; n=24;
Bacteria|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase/IMP cyclohydrolase - Porphyromonas
gingivalis (Bacteroides gingivalis)
Length = 508
Score = 64.9 bits (151), Expect = 2e-09
Identities = 29/64 (45%), Positives = 41/64 (64%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL + L+ G++ +++GGT + + G + V D+TR P MLGGRVKTLHP + G
Sbjct: 20 GLAEILAELNRQGVEFVSTGGTHEFITSLGYACRAVDDLTRYPSMLGGRVKTLHPMIFGG 79
Query: 183 ILAR 194
ILAR
Sbjct: 80 ILAR 83
Score = 33.9 bits (74), Expect = 4.5
Identities = 15/34 (44%), Positives = 23/34 (67%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLR 355
+ +LYPF TV+ + D +E IDIGG++L+R
Sbjct: 105 IVDLYPFEATVAS-GASEEDIIEKIDIGGISLIR 137
>UniRef50_Q8A155 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=5; Bacteroides|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bacteroides thetaiotaomicron
Length = 507
Score = 64.9 bits (151), Expect = 2e-09
Identities = 32/80 (40%), Positives = 49/80 (61%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL + L E G++ +++GGT + + G + V D+T P +LGGRVKTLHP + G
Sbjct: 19 GLDEIITKLYEEGVEFLSTGGTRQFIESLGYPCKAVEDLTTYPSILGGRVKTLHPKIFGG 78
Query: 183 ILARLSDSDQEDMKRQKYEM 242
IL R D +Q+ + +KYE+
Sbjct: 79 ILCR-RDLEQDIQQIEKYEI 97
Score = 37.9 bits (84), Expect = 0.27
Identities = 19/46 (41%), Positives = 29/46 (63%)
Frame = +2
Query: 221 ETSEVRDDKRGVCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
E E+ + + +LYPF TV+ + AD +E IDIGG++L+RA
Sbjct: 93 EKYEIPEIDLVIVDLYPFEATVAS-GASEADIIEKIDIGGISLIRA 137
>UniRef50_P12048 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=71; Bacteria|Rep: Bifunctional
purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Bacillus subtilis
Length = 512
Score = 64.5 bits (150), Expect = 3e-09
Identities = 27/62 (43%), Positives = 44/62 (70%)
Frame = +3
Query: 6 LLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAGI 185
L+ K L+E G+++I++GGT L+ G+ V +S++T PE++ GR+KTLHP +H G+
Sbjct: 16 LVPFVKELTELGVEVISTGGTKKLLQENGVDVIGISEVTGFPEIMDGRLKTLHPNIHGGL 75
Query: 186 LA 191
LA
Sbjct: 76 LA 77
Score = 52.0 bits (119), Expect = 2e-05
Identities = 23/35 (65%), Positives = 28/35 (80%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V NLYPF +T+SK DVT +A+ENIDIGG +LRA
Sbjct: 100 VVNLYPFKETISKEDVTYEEAIENIDIGGPGMLRA 134
Score = 48.0 bits (109), Expect = 3e-04
Identities = 27/69 (39%), Positives = 37/69 (53%), Gaps = 3/69 (4%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS---DLTSPYRTT 531
+KNH VTV+ DPADY V+ +IKE SL ++ LA K F HT+ L + Y T
Sbjct: 136 SKNHQDVTVIVDPADYSPVLNQIKE--EGSVSLQKKRELAAKVFRHTAAYDALIADYLTN 193
Query: 532 SASNTRPDK 558
P++
Sbjct: 194 VVGEKEPEQ 202
>UniRef50_Q6L122 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=4; Thermoplasmatales|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Picrophilus torridus
Length = 494
Score = 61.7 bits (143), Expect = 2e-08
Identities = 32/78 (41%), Positives = 48/78 (61%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GL L + L+ + A+ GT L ++G+ + +SDIT ++L GRVKTLHPAV +G
Sbjct: 12 GLTDLLRHLNG---DVYATPGTFKFLSDSGIKAKRISDITGFDDLLNGRVKTLHPAVFSG 68
Query: 183 ILARLSDSDQEDMKRQKY 236
IL+R + + D+KR Y
Sbjct: 69 ILSRRDEQSEADLKRYNY 86
Score = 44.0 bits (99), Expect = 0.004
Identities = 19/48 (39%), Positives = 32/48 (66%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
AKN+ VTV P DY++++K++++ + SL TR+ LAL+AF +
Sbjct: 126 AKNYQHVTVASSPEDYNIIIKDLRDG---EISLRTRETLALRAFARAA 170
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/35 (48%), Positives = 25/35 (71%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
+CNLY F + K ++ D +ENIDIGG++L+RA
Sbjct: 93 ICNLYNFESYIDK---SIEDMIENIDIGGLSLIRA 124
>UniRef50_Q8D244 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=2; Gammaproteobacteria|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Wigglesworthia glossinidia
brevipalpis
Length = 529
Score = 60.9 bits (141), Expect = 3e-08
Identities = 30/82 (36%), Positives = 51/82 (62%), Gaps = 1/82 (1%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G+ SLAK+L + ++LI + GT L G+ VS+ PE++ GRVKTLHP +H G
Sbjct: 20 GIFSLAKNLIKHKVKLITTSGTYKYLLEKGIFSTSVSEYINHPEIINGRVKTLHPKIHGG 79
Query: 183 ILARLSD-SDQEDMKRQKYEMI 245
IL+ + ++ +++ +K +M+
Sbjct: 80 ILSNNKNINENKNLNIKKIDMV 101
Score = 39.9 bits (89), Expect = 0.068
Identities = 15/35 (42%), Positives = 24/35 (68%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
+ N YPF + V K ++ + + ++NIDIGGV L R+
Sbjct: 102 ITNFYPFKKKVKKENIKIENIIDNIDIGGVALARS 136
>UniRef50_A1G3C3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=1; Salinispora arenicola
CNS205|Rep: Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Salinispora arenicola CNS205
Length = 190
Score = 58.8 bits (136), Expect = 1e-07
Identities = 31/71 (43%), Positives = 45/71 (63%)
Frame = +3
Query: 15 LAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAGILAR 194
LA L G ++A+ GT LR+ G+TV VSD+ P +LGGRVKTL ++ GILAR
Sbjct: 16 LATGLLGLGWDVVATEGTRRLLRDHGVTVGAVSDLAGVPTLLGGRVKTLTVSLMGGILAR 75
Query: 195 LSDSDQEDMKR 227
+D+ +++R
Sbjct: 76 DEPADRAEVER 86
>UniRef50_Q9X0X6 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=4; Thermotogaceae|Rep:
Bifunctional purine biosynthesis protein purH [Includes:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Thermotoga maritima
Length = 452
Score = 58.0 bits (134), Expect = 2e-07
Identities = 29/60 (48%), Positives = 38/60 (63%)
Frame = +3
Query: 9 LSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAGIL 188
L + + L E G ++ AS GTA L++ G+ DVS IT +LGG VKTLHP + AGIL
Sbjct: 15 LDILRELHEKGWEIWASSGTAKFLKSNGIEANDVSTITGFENLLGGLVKTLHPEIFAGIL 74
Score = 34.3 bits (75), Expect = 3.4
Identities = 21/50 (42%), Positives = 27/50 (54%)
Frame = +3
Query: 564 LTLRYGMNPHQKPAQVFTTRDSLPITTLNGAPGFINLCDALNAWQLVKEL 713
L LRYG NPH+K A V+ + + I F N+ DA NAW + K L
Sbjct: 167 LQLRYGENPHEK-AFVY-GKPAFEILHEGKTISFNNILDAENAWFMAKNL 214
>UniRef50_Q6MIZ2 Cluster: IMP cyclohydrolase; n=1; Bdellovibrio
bacteriovorus|Rep: IMP cyclohydrolase - Bdellovibrio
bacteriovorus
Length = 507
Score = 55.6 bits (128), Expect = 1e-06
Identities = 30/69 (43%), Positives = 42/69 (60%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
GLL LAK+L+ ++LIASGGTA AL AGL V V ++ E GR+KT+ + +
Sbjct: 16 GLLELAKNLAAQNVELIASGGTAKALTEAGLKVTAVETLSGKGEAFNGRMKTISFEIASS 75
Query: 183 ILARLSDSD 209
+L R D +
Sbjct: 76 LLFRRQDEN 84
Score = 39.1 bits (87), Expect = 0.12
Identities = 20/35 (57%), Positives = 23/35 (65%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V NLYPF T+ K + +ENIDIGG TLLRA
Sbjct: 101 VVNLYPFHATLQK-QAGFEECIENIDIGGPTLLRA 134
Score = 36.7 bits (81), Expect = 0.63
Identities = 19/48 (39%), Positives = 27/48 (56%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
AKN VTV+CDP+ Y +KE N + T+ RQ+ A +T T+
Sbjct: 136 AKNFHSVTVLCDPSQYSEFLKEFNGN-NGSTTWEFRQKCAAAVYTMTA 182
>UniRef50_A7PK27 Cluster: Chromosome chr15 scaffold_19, whole genome
shotgun sequence; n=1; Vitis vinifera|Rep: Chromosome
chr15 scaffold_19, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 227
Score = 55.2 bits (127), Expect = 2e-06
Identities = 27/63 (42%), Positives = 37/63 (58%)
Frame = +3
Query: 6 LLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAGI 185
L L SL G ++++ GGT AL NA ++ V +T P++L G VKTLHP + GI
Sbjct: 34 LAFLGNSLQILGYRIVSFGGTTLALENAWVSTTKVEQLTCFPKILDGHVKTLHPNIQGGI 93
Query: 186 LAR 194
L R
Sbjct: 94 LPR 96
>UniRef50_A5B1A5 Cluster: DNA-directed RNA polymerase; n=1; Vitis
vinifera|Rep: DNA-directed RNA polymerase - Vitis
vinifera (Grape)
Length = 202
Score = 55.2 bits (127), Expect = 2e-06
Identities = 27/63 (42%), Positives = 37/63 (58%)
Frame = +3
Query: 6 LLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAGI 185
L L SL G ++++ GGT AL NA ++ V +T P++L G VKTLHP + GI
Sbjct: 34 LAFLGNSLQILGYRIVSFGGTTLALENAWVSTTKVEQLTCFPKILDGHVKTLHPNIQGGI 93
Query: 186 LAR 194
L R
Sbjct: 94 LPR 96
>UniRef50_Q89B23 Cluster: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)]; n=2; Buchnera aphidicola (Baizongia
pistaciae)|Rep: Bifunctional purine biosynthesis protein
purH [Includes: Phosphoribosylaminoimidazolecarboxamide
formyltransferase (EC 2.1.2.3) (AICAR transformylase);
IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP
synthetase) (ATIC)] - Buchnera aphidicola subsp.
Baizongia pistaciae
Length = 529
Score = 53.2 bits (122), Expect = 7e-06
Identities = 23/63 (36%), Positives = 40/63 (63%)
Frame = +3
Query: 6 LLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAGI 185
++ +KSL ++L A+ GTA L+ + D+++ T PE++ GR+KTLH ++A I
Sbjct: 20 IIEFSKSLISKNIKLFATKGTANFLKKNNIYATDITNYTNFPEIMNGRIKTLHHKIYASI 79
Query: 186 LAR 194
LA+
Sbjct: 80 LAQ 82
Score = 34.7 bits (76), Expect = 2.6
Identities = 14/35 (40%), Positives = 23/35 (65%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRA 358
V N YPF + + ++ + D +E+IDIGG ++RA
Sbjct: 102 VINFYPFEEASNNTNLHLNDIIEHIDIGGPAIVRA 136
>UniRef50_A4MAE3 Cluster: Phosphoribosylaminoimidazolecarboxamide
formyltransferase; n=1; Petrotoga mobilis SJ95|Rep:
Phosphoribosylaminoimidazolecarboxamide
formyltransferase - Petrotoga mobilis SJ95
Length = 489
Score = 51.2 bits (117), Expect = 3e-05
Identities = 26/71 (36%), Positives = 41/71 (57%)
Frame = +3
Query: 6 LLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAGI 185
L LA L G+++I + GT L+ G+ ++D PE+LGGRVK++ P + GI
Sbjct: 16 LEDLASFLYRNGVEIICTEGTNKYLQEKGIPTVKMADYIGFPEILGGRVKSIDPKLAGGI 75
Query: 186 LARLSDSDQED 218
LA+ +D E+
Sbjct: 76 LAKSNDKKHEE 86
Score = 33.9 bits (74), Expect = 4.5
Identities = 18/48 (37%), Positives = 26/48 (54%)
Frame = +1
Query: 361 AKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
AKN+ V + DP DY V+ +++ L R++LALK F TS
Sbjct: 135 AKNYKDVVALADPKDYQTVIDNLED--CGDVPLQLRRKLALKVFFSTS 180
>UniRef50_A1IEQ8 Cluster: IMP cyclohydrolase; n=1; Candidatus
Desulfococcus oleovorans Hxd3|Rep: IMP cyclohydrolase -
Candidatus Desulfococcus oleovorans Hxd3
Length = 225
Score = 47.6 bits (108), Expect = 3e-04
Identities = 22/38 (57%), Positives = 27/38 (71%)
Frame = +2
Query: 254 VCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRAQPR 367
V NLYPF QTV++PDVT A NIDIGG ++RA +
Sbjct: 119 VVNLYPFSQTVARPDVTPEQARGNIDIGGPCMVRASAK 156
Score = 45.2 bits (102), Expect = 0.002
Identities = 25/49 (51%), Positives = 31/49 (63%)
Frame = +1
Query: 358 TAKNHDRVTVVCDPADYDVVVKEIKENKHHQTSLGTRQRLALKAFTHTS 504
+AKN RV V DPADY+ V E+ E++ SL TR LA KAF HT+
Sbjct: 154 SAKNFLRVASVVDPADYNTVADEM-EHRQGALSLDTRFELAQKAFDHTA 201
Score = 34.7 bits (76), Expect = 2.6
Identities = 19/41 (46%), Positives = 24/41 (58%), Gaps = 1/41 (2%)
Frame = +3
Query: 108 VSDITRAPEMLGGRVKTLHPAVHAGILAR-LSDSDQEDMKR 227
VSD T PE GG VKTL ++ G+L ++S DMKR
Sbjct: 69 VSDYTGQPETQGGLVKTLDFKIYLGLLTETYNESHARDMKR 109
>UniRef50_Q3JNS9 Cluster: Putative uncharacterized protein; n=9;
Burkholderia|Rep: Putative uncharacterized protein -
Burkholderia pseudomallei (strain 1710b)
Length = 917
Score = 43.2 bits (97), Expect = 0.007
Identities = 23/34 (67%), Positives = 24/34 (70%)
Frame = -3
Query: 355 AQEGHAADVDVLDRVRHGHVRLRYRLDERVQVTD 254
AQ AADVDVLDRV V LR RLDER+QV D
Sbjct: 723 AQHRRAADVDVLDRVGERAVVLRNRLDERIQVHD 756
>UniRef50_O28464 Cluster: Inosine monophosphate cyclohydrolase; n=1;
Archaeoglobus fulgidus|Rep: Inosine monophosphate
cyclohydrolase - Archaeoglobus fulgidus
Length = 157
Score = 43.2 bits (97), Expect = 0.007
Identities = 23/63 (36%), Positives = 37/63 (58%)
Frame = +3
Query: 3 GLLSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAG 182
G+ LAK L+E G +++A+ GTA L+ G+ +S+IT E +KTLHP ++
Sbjct: 12 GIECLAKRLAEMGYEILATEGTADYLQEKGVNALKLSEITGIAE--SKSIKTLHPKIYEM 69
Query: 183 ILA 191
I +
Sbjct: 70 IFS 72
>UniRef50_A1FWI7 Cluster: Putative uncharacterized protein
precursor; n=1; Stenotrophomonas maltophilia R551-3|Rep:
Putative uncharacterized protein precursor -
Stenotrophomonas maltophilia R551-3
Length = 589
Score = 37.5 bits (83), Expect = 0.36
Identities = 18/41 (43%), Positives = 23/41 (56%)
Frame = -2
Query: 149 PTSEHLRCSRDVRHILNCEAGVPKRRGGTATGNQLQATFRQ 27
P H R + DV H+L+ +A + R GG A G QL A RQ
Sbjct: 490 PAVHHFREAGDVGHVLHGQARIADRLGGAAGGQQLHAACRQ 530
>UniRef50_Q08W60 Cluster: Putative uncharacterized protein; n=1;
Stigmatella aurantiaca DW4/3-1|Rep: Putative
uncharacterized protein - Stigmatella aurantiaca DW4/3-1
Length = 611
Score = 36.7 bits (81), Expect = 0.63
Identities = 20/66 (30%), Positives = 32/66 (48%)
Frame = +2
Query: 212 GRHETSEVRDDKRGVCNLYPFVQTVSKPDVTVADAVENIDIGGVTLLRAQPRTTTGSPSS 391
G ETSE+R++ N+ P Q ++ VE + +GG L+A P TT + ++
Sbjct: 239 GHSETSELREESHDGGNIPPSRQPTRLLELAGGQLVEAVHMGGRRSLQAAPTATTATTTT 298
Query: 392 VTRPTT 409
T T
Sbjct: 299 TTTTAT 304
>UniRef50_Q5FJY6 Cluster: Carbamoyl-phosphate synthase large subunit;
n=5; Lactobacillus|Rep: Carbamoyl-phosphate synthase
large subunit - Lactobacillus acidophilus
Length = 1061
Score = 36.3 bits (80), Expect = 0.84
Identities = 22/71 (30%), Positives = 33/71 (46%)
Frame = +3
Query: 15 LAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAGILAR 194
LA+ G +L+A+ GTA AG+T V + P L +++ H V +
Sbjct: 956 LARRFDRLGFKLVATEGTANIFAEAGITTGIVEKVHNNPRNLLEKIRQ-HKIVMVVNITN 1014
Query: 195 LSDSDQEDMKR 227
LSD+ ED R
Sbjct: 1015 LSDAASEDALR 1025
>UniRef50_A5B3D8 Cluster: DNA-directed RNA polymerase; n=1; Vitis
vinifera|Rep: DNA-directed RNA polymerase - Vitis
vinifera (Grape)
Length = 153
Score = 35.9 bits (79), Expect = 1.1
Identities = 15/20 (75%), Positives = 16/20 (80%)
Frame = +3
Query: 135 MLGGRVKTLHPAVHAGILAR 194
ML G VKTLHP +H GILAR
Sbjct: 1 MLDGHVKTLHPNIHGGILAR 20
>UniRef50_A1HBX2 Cluster: Putative uncharacterized protein; n=2;
Ralstonia pickettii|Rep: Putative uncharacterized
protein - Ralstonia pickettii 12J
Length = 699
Score = 35.1 bits (77), Expect = 1.9
Identities = 20/32 (62%), Positives = 21/32 (65%)
Frame = -3
Query: 355 AQEGHAADVDVLDRVRHGHVRLRYRLDERVQV 260
AQ G AADVDVLD V L +RL ERVQV
Sbjct: 434 AQHGRAADVDVLDGVGQRAFVLGHRLLERVQV 465
>UniRef50_A4M1L4 Cluster: Putative uncharacterized protein; n=1;
Geobacter bemidjiensis Bem|Rep: Putative uncharacterized
protein - Geobacter bemidjiensis Bem
Length = 546
Score = 34.7 bits (76), Expect = 2.6
Identities = 17/32 (53%), Positives = 21/32 (65%)
Frame = -3
Query: 355 AQEGHAADVDVLDRVRHGHVRLRYRLDERVQV 260
A+ G AAD+DVLD + HG V R ERV+V
Sbjct: 412 AEHGRAADIDVLDGILHGAVLFRDGRLERVEV 443
>UniRef50_Q2VZX1 Cluster: Putative uncharacterized protein; n=1;
Magnetospirillum magneticum AMB-1|Rep: Putative
uncharacterized protein - Magnetospirillum magneticum
(strain AMB-1 / ATCC 700264)
Length = 309
Score = 33.9 bits (74), Expect = 4.5
Identities = 20/52 (38%), Positives = 31/52 (59%), Gaps = 1/52 (1%)
Frame = +3
Query: 51 IASGGTATALRNAGLTVQDVSDITRAPEM-LGGRVKTLHPAVHAGILARLSD 203
+ + GT T RN+ TV+ SDIT A + +GG T+ A+ AG++ R +D
Sbjct: 58 VQNSGTITEARNSWGTVKTGSDITEASIVNIGGIETTIKAAMAAGMVTRNAD 109
>UniRef50_Q53PF8 Cluster: Putative uncharacterized protein; n=1;
Oryza sativa (japonica cultivar-group)|Rep: Putative
uncharacterized protein - Oryza sativa subsp. japonica
(Rice)
Length = 289
Score = 33.9 bits (74), Expect = 4.5
Identities = 17/49 (34%), Positives = 23/49 (46%)
Frame = +2
Query: 32 GMWPAVDCQWRYRHGASERRPHSSRCVGHHESTGDARRSGENFTSSGTR 178
G P +W+ RHGA + S R G + GD+RR T+ G R
Sbjct: 16 GARPCARRRWKGRHGAGAKEEASGRSDGFGVAQGDSRRVAAQGTARGER 64
>UniRef50_P77886 Cluster: Carbamoyl-phosphate synthase
pyrimidine-specific large chain; n=32; Firmicutes|Rep:
Carbamoyl-phosphate synthase pyrimidine-specific large
chain - Lactobacillus plantarum
Length = 1058
Score = 33.9 bits (74), Expect = 4.5
Identities = 24/70 (34%), Positives = 35/70 (50%)
Frame = +3
Query: 9 LSLAKSLSECGLQLIASGGTATALRNAGLTVQDVSDITRAPEMLGGRVKTLHPAVHAGIL 188
++LAK G QL+A+ GTATAL GL V V I L R++ V ++
Sbjct: 951 VALAKRFHALGYQLLATRGTATALTTHGLPVTTVDKIDSGERDLLHRMEAGEIQV---VI 1007
Query: 189 ARLSDSDQED 218
+SD +Q +
Sbjct: 1008 NTVSDEEQAE 1017
>UniRef50_Q28WT5 Cluster: GA17407-PA; n=2; Coelomata|Rep: GA17407-PA -
Drosophila pseudoobscura (Fruit fly)
Length = 2180
Score = 33.5 bits (73), Expect = 5.9
Identities = 22/59 (37%), Positives = 29/59 (49%)
Frame = -1
Query: 408 VVGRVTDDGDPVVVLGCARRRVTPPMSMFSTASATVTSGLDTVWTNGYRLQTPRLSSRT 232
+V RV+ G P AR R + P + +T SAT T G+ T T GY + S RT
Sbjct: 2041 MVTRVSLPGQPSAAAEQARSRPSLPAKIPTTQSATQTEGVATKCTYGYMVSNGLPSYRT 2099
>UniRef50_Q6NM73 Cluster: Cysteine-rich repeat secretory protein 3
precursor; n=4; core eudicotyledons|Rep: Cysteine-rich
repeat secretory protein 3 precursor - Arabidopsis
thaliana (Mouse-ear cress)
Length = 307
Score = 33.5 bits (73), Expect = 5.9
Identities = 17/54 (31%), Positives = 30/54 (55%)
Frame = -1
Query: 450 LMMFVLFDFFDYNIVVGRVTDDGDPVVVLGCARRRVTPPMSMFSTASATVTSGL 289
+MM +LF D N+VV T + ++ GCAR++ + P ++S A + + L
Sbjct: 12 MMMCLLFP--DLNVVVKSATTEYTTLIYKGCARQQFSDPSGLYSQALSAMFGSL 63
>UniRef50_Q1JTG1 Cluster: Putative uncharacterized protein
precursor; n=1; Toxoplasma gondii RH|Rep: Putative
uncharacterized protein precursor - Toxoplasma gondii RH
Length = 1480
Score = 33.1 bits (72), Expect = 7.8
Identities = 22/68 (32%), Positives = 30/68 (44%), Gaps = 3/68 (4%)
Frame = +2
Query: 212 GRHETSEVRDDKRGVCNLYP---FVQTVSKPDVTVADAVENIDIGGVTLLRAQPRTTTGS 382
G+H E +KRG +L F + P+VT D G + A+P + T S
Sbjct: 339 GQHAAKESSPEKRGCSSLRSVDFFSTSAPHPEVTDTAKASRSDFGTQFIEGARPPSLTAS 398
Query: 383 PSSVTRPT 406
PSS R T
Sbjct: 399 PSSRQRTT 406
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 724,494,378
Number of Sequences: 1657284
Number of extensions: 14481158
Number of successful extensions: 51991
Number of sequences better than 10.0: 66
Number of HSP's better than 10.0 without gapping: 49446
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 51956
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 64204279620
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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