Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= wdS00004
(783 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_O01382 Cluster: Caspase precursor (EC 3.4.22.-) (drICE)... 141 2e-32
UniRef50_UPI0000D55B5F Cluster: PREDICTED: similar to Caspase pr... 140 4e-32
UniRef50_UPI00015B4D75 Cluster: PREDICTED: similar to CG7788-PA;... 106 7e-22
UniRef50_UPI00015B57EE Cluster: PREDICTED: similar to ENSANGP000... 105 2e-21
UniRef50_Q98UI8 Cluster: Caspase-3; n=4; Chordata|Rep: Caspase-3... 95 1e-18
UniRef50_Q7Q1E0 Cluster: ENSANGP00000015118; n=2; Culicidae|Rep:... 91 4e-17
UniRef50_P55210 Cluster: Caspase-7 precursor (EC 3.4.22.60) (CAS... 87 5e-16
UniRef50_Q5DD62 Cluster: SJCHGC00800 protein; n=3; Schistosoma j... 83 1e-14
UniRef50_Q17FE3 Cluster: Caspase-1; n=3; Endopterygota|Rep: Casp... 81 3e-14
UniRef50_P55213 Cluster: Caspase-3 precursor (EC 3.4.22.56) (CAS... 81 3e-14
UniRef50_UPI0000E48555 Cluster: PREDICTED: similar to Lice2 cyst... 79 2e-13
UniRef50_Q7Q802 Cluster: ENSANGP00000021365; n=4; Cellia|Rep: EN... 76 1e-12
UniRef50_Q8I6Y2 Cluster: Caspase-3; n=2; Geodia cydonium|Rep: Ca... 49 3e-12
UniRef50_Q7Q803 Cluster: ENSANGP00000021367; n=6; Anopheles gamb... 75 3e-12
UniRef50_Q8JIS8 Cluster: Caspase 3A; n=3; Euteleostomi|Rep: Casp... 74 4e-12
UniRef50_A1L2P4 Cluster: LOC100036910 protein; n=1; Xenopus laev... 74 4e-12
UniRef50_UPI0000519DFF Cluster: PREDICTED: similar to Caspase pr... 73 8e-12
UniRef50_Q2TM51 Cluster: Caspase; n=3; Penaeidae|Rep: Caspase - ... 71 4e-11
UniRef50_UPI0000F2097E Cluster: PREDICTED: hypothetical protein;... 67 5e-10
UniRef50_Q92851-2 Cluster: Isoform B of Q92851 ; n=9; Mammalia|R... 65 2e-09
UniRef50_Q6KF63 Cluster: Caspase 10; n=3; Catarrhini|Rep: Caspas... 65 2e-09
UniRef50_Q92851 Cluster: Caspase-10 precursor (EC 3.4.22.63) (CA... 65 2e-09
UniRef50_Q3HL92 Cluster: Caspase-like protein; n=6; Eumetazoa|Re... 65 2e-09
UniRef50_Q7QKT2 Cluster: ENSANGP00000015505; n=3; Anopheles gamb... 64 3e-09
UniRef50_UPI0000E49D20 Cluster: PREDICTED: hypothetical protein;... 63 7e-09
UniRef50_Q4RG79 Cluster: Chromosome 2 SCAF15106, whole genome sh... 63 7e-09
UniRef50_A7SPA7 Cluster: Predicted protein; n=1; Nematostella ve... 63 9e-09
UniRef50_A7S4V9 Cluster: Predicted protein; n=2; Nematostella ve... 62 2e-08
UniRef50_Q14790 Cluster: Caspase-8 precursor (EC 3.4.22.61) (CAS... 61 4e-08
UniRef50_UPI00015553DC Cluster: PREDICTED: similar to caspase-15... 60 5e-08
UniRef50_Q9I8J3 Cluster: Caspase-8; n=11; Danio rerio|Rep: Caspa... 60 5e-08
UniRef50_UPI0000E48C15 Cluster: PREDICTED: similar to caspase 8;... 60 6e-08
UniRef50_Q0WYJ4 Cluster: Caspase 10; n=4; Percomorpha|Rep: Caspa... 60 8e-08
UniRef50_Q09HM6 Cluster: Caspase-8; n=1; Molgula tectiformis|Rep... 60 8e-08
UniRef50_A7SXL6 Cluster: Predicted protein; n=1; Nematostella ve... 59 1e-07
UniRef50_A7S119 Cluster: Predicted protein; n=1; Nematostella ve... 59 1e-07
UniRef50_Q9NHF9 Cluster: Caspase 6-like protein BG2; n=3; Sophop... 58 2e-07
UniRef50_A2BGE2 Cluster: Novel protein similar to caspase 8; n=4... 58 3e-07
UniRef50_UPI0000E472FD Cluster: PREDICTED: similar to caspase 8;... 57 6e-07
UniRef50_P55212 Cluster: Caspase-6 precursor (EC 3.4.22.59) (CAS... 56 1e-06
UniRef50_UPI0000ECB87F Cluster: Caspase-10 precursor (EC 3.4.22.... 55 2e-06
UniRef50_Q5C0Y4 Cluster: SJCHGC07329 protein; n=1; Schistosoma j... 55 2e-06
UniRef50_Q16FR8 Cluster: Caspase-1; n=1; Aedes aegypti|Rep: Casp... 55 2e-06
UniRef50_UPI0000F2DFE7 Cluster: PREDICTED: similar to apoptotic ... 55 2e-06
UniRef50_A5JSK5 Cluster: Cysteine protease; n=2; Eukaryota|Rep: ... 55 2e-06
UniRef50_Q16PQ5 Cluster: Ecdysone-inducible caspase, putative; n... 55 2e-06
UniRef50_UPI0000586459 Cluster: PREDICTED: similar to caspase-3,... 54 3e-06
UniRef50_Q8I749 Cluster: Caspase-related protein; n=1; Suberites... 54 3e-06
UniRef50_A7S9L1 Cluster: Predicted protein; n=1; Nematostella ve... 54 3e-06
UniRef50_Q9IB64 Cluster: Caspase-8; n=1; Xenopus laevis|Rep: Cas... 54 4e-06
UniRef50_Q9IB62 Cluster: Caspase-10; n=5; Xenopus|Rep: Caspase-1... 54 5e-06
UniRef50_Q5D0W5 Cluster: Caspase 3C; n=2; Hydra vulgaris|Rep: Ca... 53 7e-06
UniRef50_UPI0001554FA5 Cluster: PREDICTED: similar to initiator ... 53 9e-06
UniRef50_Q2HZ04 Cluster: ICE-5; n=3; Bombyx mori|Rep: ICE-5 - Bo... 53 9e-06
UniRef50_UPI00015B57F0 Cluster: PREDICTED: similar to GA20532-PA... 52 1e-05
UniRef50_Q4JQQ0 Cluster: Initiator caspase; n=2; Gallus gallus|R... 52 1e-05
UniRef50_P31944 Cluster: Caspase-14 precursor (EC 3.4.22.-) (CAS... 52 1e-05
UniRef50_Q8ITP2 Cluster: AmphiCASP-6; n=2; Chordata|Rep: AmphiCA... 52 2e-05
UniRef50_Q6E5N8 Cluster: Caspase 8; n=1; Ictalurus punctatus|Rep... 52 2e-05
UniRef50_UPI00015B59A2 Cluster: PREDICTED: similar to ecdysone-i... 51 3e-05
UniRef50_Q4FJK5 Cluster: Casp9 protein; n=20; Eutheria|Rep: Casp... 51 3e-05
UniRef50_Q90WU0 Cluster: Caspase 9; n=2; Gallus gallus|Rep: Casp... 51 4e-05
UniRef50_Q4SC67 Cluster: Chromosome undetermined SCAF14659, whol... 51 4e-05
UniRef50_Q3T2L0 Cluster: Caspase-15; n=11; Theria|Rep: Caspase-1... 51 4e-05
UniRef50_A3QVU6 Cluster: Initiator caspase; n=3; Culicidae|Rep: ... 51 4e-05
UniRef50_UPI000065FEF6 Cluster: Homolog of Ictalurus punctatus "... 50 5e-05
UniRef50_Q28GK9 Cluster: Novel protein; n=1; Xenopus tropicalis|... 50 7e-05
UniRef50_Q0PKX0 Cluster: Caspase Xa; n=4; Danio rerio|Rep: Caspa... 49 1e-04
UniRef50_P55211 Cluster: Caspase-9 precursor (EC 3.4.22.62) (CAS... 49 1e-04
UniRef50_UPI0000E82482 Cluster: PREDICTED: hypothetical protein;... 48 2e-04
UniRef50_UPI0000F2DFE8 Cluster: PREDICTED: similar to initiator ... 48 3e-04
UniRef50_Q56VC9 Cluster: Caspase-8; n=3; Euteleostei|Rep: Caspas... 48 3e-04
UniRef50_Q4V923 Cluster: Zgc:101776 protein; n=8; Clupeocephala|... 47 5e-04
UniRef50_UPI0000F1EFFE Cluster: PREDICTED: hypothetical protein;... 47 6e-04
UniRef50_P42575 Cluster: Caspase-2 precursor (EC 3.4.22.55) (CAS... 46 0.001
UniRef50_UPI0000E4A098 Cluster: PREDICTED: similar to CGI-141 pr... 46 0.001
UniRef50_Q9Y1U6 Cluster: Cell death protein CED-3; n=1; Pristion... 46 0.001
UniRef50_UPI0000F1EBE3 Cluster: PREDICTED: similar to caspase 10... 45 0.002
UniRef50_Q9GV89 Cluster: Caspase 3A; n=1; Hydra vulgaris|Rep: Ca... 45 0.002
UniRef50_UPI00006A1E20 Cluster: Caspase-9 precursor (EC 3.4.22.6... 45 0.002
UniRef50_Q4SNC6 Cluster: Chromosome 8 SCAF14543, whole genome sh... 45 0.002
UniRef50_Q69HP8 Cluster: Caspase-1-like; n=1; Ciona intestinalis... 44 0.004
UniRef50_UPI0000F21D96 Cluster: PREDICTED: hypothetical protein,... 44 0.006
UniRef50_A2I5C3 Cluster: Putative caspase 3; n=1; Mytilus gallop... 44 0.006
UniRef50_Q4S1R8 Cluster: Chromosome undetermined SCAF14764, whol... 43 0.008
UniRef50_UPI0000F2CF2E Cluster: PREDICTED: similar to caspase 12... 42 0.017
UniRef50_UPI0000D56041 Cluster: PREDICTED: similar to CG7486-PB,... 42 0.017
UniRef50_UPI0000E45DDA Cluster: PREDICTED: similar to caspase 3;... 42 0.023
UniRef50_Q9I9L7 Cluster: Caspase; n=2; Danio rerio|Rep: Caspase ... 42 0.023
UniRef50_P55865 Cluster: Caspase-1-A precursor; n=3; Xenopus|Rep... 42 0.023
UniRef50_Q0Z8U7 Cluster: Caspase-8; n=1; Haemaphysalis longicorn... 41 0.030
UniRef50_P29466-2 Cluster: Isoform Beta of P29466 ; n=11; Theria... 40 0.053
UniRef50_P29466 Cluster: Caspase-1 precursor (EC 3.4.22.36) (CAS... 40 0.053
UniRef50_Q7ZXD2 Cluster: MGC53258 protein; n=3; Xenopus|Rep: MGC... 40 0.070
UniRef50_Q504J1 Cluster: Caspase b; n=7; Danio rerio|Rep: Caspas... 40 0.070
UniRef50_UPI0000E47913 Cluster: PREDICTED: similar to cysteine p... 40 0.093
UniRef50_UPI000155BC01 Cluster: PREDICTED: similar to cellular F... 39 0.12
UniRef50_Q07BT4 Cluster: Caspase-1; n=2; Percomorpha|Rep: Caspas... 39 0.12
UniRef50_UPI0000E47F37 Cluster: PREDICTED: similar to caspase-3,... 39 0.16
UniRef50_Q178B7 Cluster: Caspase-3; n=2; Aedes aegypti|Rep: Casp... 39 0.16
UniRef50_Q9XYF4 Cluster: Caspase Nc precursor (EC 3.4.22.-) (NED... 39 0.16
UniRef50_Q0Z855 Cluster: Caspase-2; n=1; Haemaphysalis longicorn... 38 0.28
UniRef50_A6NFM5 Cluster: Uncharacterized protein ENSP00000371619... 38 0.28
UniRef50_P42573 Cluster: Cell death protein 3 precursor (EC 3.4.... 38 0.37
UniRef50_UPI0000661247 Cluster: Homolog of Brachydanio rerio "Ca... 37 0.50
UniRef50_A3QU14 Cluster: DNA polymerase; n=1; Oryctes rhinoceros... 37 0.50
UniRef50_UPI0000F2CF2D Cluster: PREDICTED: similar to evolutiona... 37 0.65
UniRef50_UPI000065DDFC Cluster: CASP8 and FADD-like apoptosis re... 37 0.65
UniRef50_Q498I3 Cluster: LOC780745 protein; n=6; Xenopus|Rep: LO... 37 0.65
UniRef50_P51878 Cluster: Caspase-5 precursor (EC 3.4.22.58) (CAS... 36 0.86
UniRef50_O15519-8 Cluster: Isoform 8 of O15519 ; n=3; Homo/Pan/G... 36 1.1
UniRef50_O15519 Cluster: CASP8 and FADD-like apoptosis regulator... 36 1.1
UniRef50_UPI000051A33A Cluster: PREDICTED: similar to CG6597-PA,... 36 1.5
UniRef50_O42284 Cluster: Caspase-1; n=3; Gallus gallus|Rep: Casp... 35 2.0
UniRef50_Q7KHK9 Cluster: DREAM; n=2; Sophophora|Rep: DREAM - Dro... 34 3.5
UniRef50_P29466-4 Cluster: Isoform Delta of P29466 ; n=2; Euarch... 33 6.1
UniRef50_Q74BT1 Cluster: Fibronectin type III domain protein; n=... 33 6.1
UniRef50_Q9NBW3 Cluster: Cysteine protease; n=4; melanogaster su... 33 8.1
UniRef50_Q8I5D6 Cluster: Putative uncharacterized protein; n=3; ... 33 8.1
>UniRef50_O01382 Cluster: Caspase precursor (EC 3.4.22.-) (drICE)
[Contains: Caspase subunit p21; Caspase subunit p12];
n=13; Endopterygota|Rep: Caspase precursor (EC 3.4.22.-)
(drICE) [Contains: Caspase subunit p21; Caspase subunit
p12] - Drosophila melanogaster (Fruit fly)
Length = 339
Score = 141 bits (342), Expect = 2e-32
Identities = 60/85 (70%), Positives = 72/85 (84%), Gaps = 2/85 (2%)
Frame = +3
Query: 6 ETHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITL--SNTETDGXXXXXYR 179
+T YK DN+W +FTA+ CP+LAGKPKLFFIQACQGD+LDGG+T+ S TETDG Y+
Sbjct: 179 DTQYKLDNIWSFFTANHCPSLAGKPKLFFIQACQGDRLDGGVTMQRSQTETDGDSSMSYK 238
Query: 180 IPIHADFLIVFSTVPGYYSWRNTTR 254
IP+HADFLI +STVPG+YSWRNTTR
Sbjct: 239 IPVHADFLIAYSTVPGFYSWRNTTR 263
Score = 98.3 bits (234), Expect = 2e-19
Identities = 45/60 (75%), Positives = 49/60 (81%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWFMQSLC EL G + DILTLLTFVCQRVA+DFES TPD MHQQKQ+PCI +MLTR
Sbjct: 265 SWFMQSLCAELAANGKRLDILTLLTFVCQRVAVDFESCTPDTPEMHQQKQIPCITTMLTR 324
>UniRef50_UPI0000D55B5F Cluster: PREDICTED: similar to Caspase
precursor (drICE); n=1; Tribolium castaneum|Rep:
PREDICTED: similar to Caspase precursor (drICE) -
Tribolium castaneum
Length = 309
Score = 140 bits (339), Expect = 4e-32
Identities = 61/84 (72%), Positives = 69/84 (82%), Gaps = 1/84 (1%)
Frame = +3
Query: 6 ETHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG-XXXXXYRI 182
+T YKPD LW YF AD+CP+LAGKPK+FF+QACQGDKLDGG+ LS TETDG YRI
Sbjct: 155 DTQYKPDLLWSYFAADRCPSLAGKPKIFFLQACQGDKLDGGVILSRTETDGHLEIDSYRI 214
Query: 183 PIHADFLIVFSTVPGYYSWRNTTR 254
P ADFL+V+STV GYYSWRNTTR
Sbjct: 215 PAQADFLVVYSTVKGYYSWRNTTR 238
Score = 94.3 bits (224), Expect = 3e-18
Identities = 42/60 (70%), Positives = 48/60 (80%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+Q+LCEELRN G D+ T+LTFV QRVA DFESN PD MHQQKQ+PC+ SMLTR
Sbjct: 240 SWFIQALCEELRNKGFDYDLGTILTFVSQRVAFDFESNCPDSPTMHQQKQIPCVMSMLTR 299
>UniRef50_UPI00015B4D75 Cluster: PREDICTED: similar to CG7788-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
CG7788-PA - Nasonia vitripennis
Length = 456
Score = 106 bits (254), Expect = 7e-22
Identities = 44/83 (53%), Positives = 58/83 (69%), Gaps = 2/83 (2%)
Frame = +3
Query: 3 HETHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS--NTETDGXXXXXY 176
H+ Y +++W FT+ CP+L GKP+LFFIQAC+GD+ D GI L +E DG +
Sbjct: 303 HDRKYNAESIWSSFTSSNCPSLEGKPRLFFIQACRGDQTDEGIKLQYCRSEPDGHPNLVF 362
Query: 177 RIPIHADFLIVFSTVPGYYSWRN 245
RIP H DFLI +ST+PG+YSWRN
Sbjct: 363 RIPTHRDFLIAYSTIPGFYSWRN 385
Score = 87.4 bits (207), Expect = 4e-16
Identities = 36/60 (60%), Positives = 49/60 (81%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+Q+LC EL YG ++D+LT+LTFVCQRVA+DFES +P+ HQ+KQ+P + +MLTR
Sbjct: 390 SWFVQALCSELDVYGDRQDLLTILTFVCQRVAIDFESYSPERANFHQKKQIPAVTTMLTR 449
>UniRef50_UPI00015B57EE Cluster: PREDICTED: similar to
ENSANGP00000010319; n=2; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000010319 - Nasonia
vitripennis
Length = 379
Score = 105 bits (251), Expect = 2e-21
Identities = 53/95 (55%), Positives = 63/95 (66%), Gaps = 7/95 (7%)
Frame = +3
Query: 15 YKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITL---SNTETDGXXXXXYRIP 185
YK +N+W FTADKC +LAGKPKLFF QAC+GD LDGGI + TETD Y+IP
Sbjct: 229 YKLENVWKPFTADKCSSLAGKPKLFFFQACRGDNLDGGIKMMRSGTTETDS-SSASYQIP 287
Query: 186 IHADFLIVFSTVPGYYSWRN----TTRALGLCNLF 278
+ADFL STV G+YSWRN T LC++F
Sbjct: 288 TYADFLFAHSTVQGFYSWRNPEEGTWYVQSLCDVF 322
Score = 49.2 bits (112), Expect = 1e-04
Identities = 24/61 (39%), Positives = 36/61 (59%), Gaps = 1/61 (1%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPM-HQQKQVPCINSMLT 433
+W++QSLC+ Y D+ L+T ++VA +F S D+ PM H +KQVP + S L
Sbjct: 312 TWYVQSLCDVFDEYAATHDLAKLMTITARKVATNFASYN-DLDPMLHGKKQVPSVISSLI 370
Query: 434 R 436
R
Sbjct: 371 R 371
>UniRef50_Q98UI8 Cluster: Caspase-3; n=4; Chordata|Rep: Caspase-3 -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 282
Score = 95.5 bits (227), Expect = 1e-18
Identities = 46/101 (45%), Positives = 58/101 (57%), Gaps = 4/101 (3%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTV 221
F D+CP+L GKPKLFFIQAC+G +LD G+ +T+ RIP+ ADFL +STV
Sbjct: 146 FRGDRCPSLVGKPKLFFIQACRGTELDPGVETDHTDHPDIPDGRERIPVEADFLYAYSTV 205
Query: 222 PGYYSWRNTTRA----LGLCNLFVKN*ETMVLKEIFLHS*H 332
PGYYSWRNT LC + K + L +I H
Sbjct: 206 PGYYSWRNTMTGSWFIQSLCEMMTKYGSELELLQIMTRVNH 246
Score = 65.3 bits (152), Expect = 2e-09
Identities = 30/60 (50%), Positives = 44/60 (73%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+QSLCE + YG++ ++L ++T V +VALDFES T ++ +KQ+PCI SMLT+
Sbjct: 218 SWFIQSLCEMMTKYGSELELLQIMTRVNHKVALDFES-TSNMPGFDAKKQIPCIVSMLTK 276
>UniRef50_Q7Q1E0 Cluster: ENSANGP00000015118; n=2; Culicidae|Rep:
ENSANGP00000015118 - Anopheles gambiae str. PEST
Length = 294
Score = 90.6 bits (215), Expect = 4e-17
Identities = 40/94 (42%), Positives = 60/94 (63%)
Frame = +3
Query: 3 HETHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRI 182
++ Y+ +W +FTAD CP+LAG+PK+F +QAC+G++LD G+ + DG Y I
Sbjct: 149 YDQPYELSLIWSFFTADNCPSLAGRPKIFVVQACRGNQLDHGV---KVQKDG--VARYSI 203
Query: 183 PIHADFLIVFSTVPGYYSWRNTTRALGLCNLFVK 284
P HADFL ++T+PG+ ++RNTT N K
Sbjct: 204 PTHADFLFAYATIPGFMAFRNTTEGSWFINELCK 237
Score = 63.3 bits (147), Expect = 7e-09
Identities = 31/60 (51%), Positives = 41/60 (68%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+ LC+EL+ G + DI TLLTFV Q+VA D ES ++ + +KQ PC+ SMLTR
Sbjct: 229 SWFINELCKELQENGHRYDINTLLTFVTQKVAYDHES-VSNMPEYNMRKQTPCVVSMLTR 287
>UniRef50_P55210 Cluster: Caspase-7 precursor (EC 3.4.22.60)
(CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3)
(Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7
subunit p20; Caspase-7 subunit p11]; n=58;
Euteleostomi|Rep: Caspase-7 precursor (EC 3.4.22.60)
(CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3)
(Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7
subunit p20; Caspase-7 subunit p11] - Homo sapiens
(Human)
Length = 303
Score = 87.0 bits (206), Expect = 5e-16
Identities = 41/77 (53%), Positives = 50/77 (64%), Gaps = 1/77 (1%)
Frame = +3
Query: 27 NLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITL-SNTETDGXXXXXYRIPIHADFL 203
+L +F D+C TL KPKLFFIQAC+G +LD GI S D Y+IP+ ADFL
Sbjct: 161 DLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFL 220
Query: 204 IVFSTVPGYYSWRNTTR 254
+STVPGYYSWR+ R
Sbjct: 221 FAYSTVPGYYSWRSPGR 237
Score = 60.5 bits (140), Expect = 5e-08
Identities = 28/60 (46%), Positives = 40/60 (66%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+Q+LC L +G +I+ +LT V RVA FES + D H++KQ+PC+ SMLT+
Sbjct: 239 SWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDD-PHFHEKKQIPCVVSMLTK 297
>UniRef50_Q5DD62 Cluster: SJCHGC00800 protein; n=3; Schistosoma
japonicum|Rep: SJCHGC00800 protein - Schistosoma
japonicum (Blood fluke)
Length = 288
Score = 82.6 bits (195), Expect = 1e-14
Identities = 33/72 (45%), Positives = 49/72 (68%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFST 218
+F D+CP+L GKPKLFF QAC+G D G++ + G ++P+ AD L+ +ST
Sbjct: 143 FFRGDRCPSLIGKPKLFFFQACRGVSFDKGVSTMVADA-GDDVIVRKLPVEADILVSYST 201
Query: 219 VPGYYSWRNTTR 254
VPGY++WRN+T+
Sbjct: 202 VPGYFAWRNSTK 213
Score = 39.5 bits (88), Expect = 0.093
Identities = 24/63 (38%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Frame = +2
Query: 257 SWFMQSLCEELRN---YGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSM 427
SW++Q LC L G DI+TLLT V + VA + S+T + KQ+ S
Sbjct: 215 SWYIQELCNALETDIKNGNHTDIMTLLTVVARVVAYQYRSSTRQV-ETDNMKQMTSTFST 273
Query: 428 LTR 436
LTR
Sbjct: 274 LTR 276
>UniRef50_Q17FE3 Cluster: Caspase-1; n=3; Endopterygota|Rep:
Caspase-1 - Aedes aegypti (Yellowfever mosquito)
Length = 293
Score = 81.0 bits (191), Expect = 3e-14
Identities = 36/85 (42%), Positives = 50/85 (58%), Gaps = 5/85 (5%)
Frame = +3
Query: 6 ETHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS-----NTETDGXXXX 170
+ Y D+LW F + CP+L GKPK+FFIQAC+G++ D G+ + +
Sbjct: 128 DNKYNVDSLWKNFVGNACPSLIGKPKMFFIQACRGEQFDEGVAYAAKSPKDMVDSRQEQV 187
Query: 171 XYRIPIHADFLIVFSTVPGYYSWRN 245
Y IP AD L+++ST GYYSWRN
Sbjct: 188 LYSIPAMADLLVMYSTYDGYYSWRN 212
Score = 68.9 bits (161), Expect = 1e-10
Identities = 33/60 (55%), Positives = 40/60 (66%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+QSLC EL G RD+LTLLT V +R A +F+S P M KQ+PCI SMLT+
Sbjct: 217 SWFIQSLCTELDENGRVRDLLTLLTGVSRRTAYEFQSFVPHNAKMDAMKQIPCIVSMLTK 276
>UniRef50_P55213 Cluster: Caspase-3 precursor (EC 3.4.22.56)
(CASP-3) (Apopain) (Cysteine protease CPP32) (Yama
protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1)
(LICE) (IRP) [Contains: Caspase-3 subunit p17; Caspase-3
subunit p12]; n=32; Euteleostomi|Rep: Caspase-3
precursor (EC 3.4.22.56) (CASP-3) (Apopain) (Cysteine
protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage
activity 1) (SCA-1) (LICE) (IRP) [Contains: Caspase-3
subunit p17; Caspase-3 subunit p12] - Rattus norvegicus
(Rat)
Length = 277
Score = 81.0 bits (191), Expect = 3e-14
Identities = 39/71 (54%), Positives = 48/71 (67%), Gaps = 1/71 (1%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQGDKLDGGI-TLSNTETDGXXXXXYRIPIHADFLIVFS 215
+F D C +L GKPKLF IQAC+G +LD GI T S T+ D +IP+ ADFL +S
Sbjct: 142 FFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDDD---MACQKIPVEADFLYAYS 198
Query: 216 TVPGYYSWRNT 248
T PGYYSWRN+
Sbjct: 199 TAPGYYSWRNS 209
Score = 59.7 bits (138), Expect = 8e-08
Identities = 29/60 (48%), Positives = 42/60 (70%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+QSLC L+ Y + + + +LT V ++VA +FES + D T H +KQ+PCI SMLT+
Sbjct: 213 SWFIQSLCAMLKLYAHKLEFMHILTRVNRKVATEFESFSLDAT-FHAKKQIPCIVSMLTK 271
>UniRef50_UPI0000E48555 Cluster: PREDICTED: similar to Lice2
cysteine protease, partial; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to Lice2 cysteine
protease, partial - Strongylocentrotus purpuratus
Length = 388
Score = 78.6 bits (185), Expect = 2e-13
Identities = 36/69 (52%), Positives = 45/69 (65%), Gaps = 6/69 (8%)
Frame = +3
Query: 57 CPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG------XXXXXYRIPIHADFLIVFST 218
CPTL GKPKLFFIQAC+G ++D G+ + E D Y IP+ ADFL+ FS+
Sbjct: 249 CPTLVGKPKLFFIQACRGTQMDHGVRVPAGEGDDEPDAALGQKMFYTIPVEADFLMAFSS 308
Query: 219 VPGYYSWRN 245
PGYYSWR+
Sbjct: 309 TPGYYSWRS 317
Score = 41.5 bits (93), Expect = 0.023
Identities = 22/60 (36%), Positives = 35/60 (58%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+Q++ YGT D+ ++T V + VA +ES + D + +KQ+PC S LT+
Sbjct: 322 SWFIQAIITIFEKYGTCMDVNQMMTRVNRAVAYRYESISGD-ERYNGRKQMPCFVSTLTK 380
>UniRef50_Q7Q802 Cluster: ENSANGP00000021365; n=4; Cellia|Rep:
ENSANGP00000021365 - Anopheles gambiae str. PEST
Length = 296
Score = 75.8 bits (178), Expect = 1e-12
Identities = 34/79 (43%), Positives = 47/79 (59%), Gaps = 2/79 (2%)
Frame = +3
Query: 15 YKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS--NTETDGXXXXXYRIPI 188
Y D LW F + C TL GKPKLFF+QAC+G D G+ L + ++D Y IP
Sbjct: 144 YSVDKLWESFMGNACTTLLGKPKLFFVQACRGSTFDKGVKLGCRDLDSDHFSSHKYVIPT 203
Query: 189 HADFLIVFSTVPGYYSWRN 245
AD L+++S+ G+ SWR+
Sbjct: 204 TADLLVMYSSYKGHVSWRS 222
Score = 58.8 bits (136), Expect = 1e-07
Identities = 29/60 (48%), Positives = 38/60 (63%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+Q+LC EL ++L LLT V +RVA D++SN P M KQ+P I SMLT+
Sbjct: 227 SWFIQALCVELETNWKHMELLQLLTGVSRRVAYDYQSNEPSKGRMDAMKQMPSIVSMLTK 286
>UniRef50_Q8I6Y2 Cluster: Caspase-3; n=2; Geodia cydonium|Rep:
Caspase-3 - Geodia cydonium (Sponge)
Length = 426
Score = 48.8 bits (111), Expect(2) = 3e-12
Identities = 23/62 (37%), Positives = 31/62 (50%)
Frame = +3
Query: 135 LSNTETDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTRALGLCNLFVKN*ETMVLKEI 314
L ETDG +P ADF++ ++TVPGY SWRN+ FV + KE
Sbjct: 317 LDADETDGGGYSREALPTEADFVLAYATVPGYVSWRNSEYGSWFIKAFVDTMRDLASKEH 376
Query: 315 FL 320
F+
Sbjct: 377 FM 378
Score = 46.0 bits (104), Expect(2) = 3e-12
Identities = 19/45 (42%), Positives = 29/45 (64%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG 158
++L YF P+L GKPK+F +QAC+G K D G+ +T+ +G
Sbjct: 249 EDLTKYFDGVNRPSLIGKPKVFVVQACRGGKFDYGVESESTDGEG 293
Score = 36.3 bits (80), Expect = 0.86
Identities = 19/60 (31%), Positives = 35/60 (58%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+++ + +R+ ++ + +LT V ++VA DF+S + KQ+P +MLTR
Sbjct: 358 SWFIKAFVDTMRDLASKEHFMDILTEVNRKVAYDFQSR-------GRNKQIPAPVTMLTR 410
>UniRef50_Q7Q803 Cluster: ENSANGP00000021367; n=6; Anopheles gambiae
str. PEST|Rep: ENSANGP00000021367 - Anopheles gambiae
str. PEST
Length = 320
Score = 74.5 bits (175), Expect = 3e-12
Identities = 32/60 (53%), Positives = 47/60 (78%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+++LC+ELR +G +++L LLT V +RVA +F+SN P+ + + QKQ+PCI SMLTR
Sbjct: 254 SWFIRALCDELREHGNSKELLQLLTSVSRRVAYEFQSNVPNNSQIDCQKQMPCIVSMLTR 313
Score = 66.9 bits (156), Expect = 5e-10
Identities = 38/99 (38%), Positives = 46/99 (46%), Gaps = 22/99 (22%)
Frame = +3
Query: 15 YKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETD------------- 155
+ D LW F D CP+L GKPKLFFIQAC+G D G+ S T
Sbjct: 151 FNVDRLWENFIGDSCPSLLGKPKLFFIQACRGSSFDTGVHFSQCMTQVAKTVVPYAMREL 210
Query: 156 ---------GXXXXXYRIPIHADFLIVFSTVPGYYSWRN 245
Y IP AD L+++ST G+YSWRN
Sbjct: 211 PQPSIVPGCPKSSIQYAIPSMADLLVMYSTYKGHYSWRN 249
>UniRef50_Q8JIS8 Cluster: Caspase 3A; n=3; Euteleostomi|Rep: Caspase
3A - Oryzias latipes (Medaka fish) (Japanese ricefish)
Length = 290
Score = 74.1 bits (174), Expect = 4e-12
Identities = 42/96 (43%), Positives = 52/96 (54%), Gaps = 4/96 (4%)
Frame = +3
Query: 57 CPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTVPGYYS 236
C +L GKPKLFFIQAC+G D GI E D +IP+ ADFL +STV GYYS
Sbjct: 161 CLSLVGKPKLFFIQACRGMLFDEGI-----EHDAKDDTSEKIPLEADFLFAYSTVSGYYS 215
Query: 237 WRNTTRA----LGLCNLFVKN*ETMVLKEIFLHS*H 332
WR+T LC + K +T+ L +I H
Sbjct: 216 WRSTANGSWFIQSLCEMLEKFSKTLDLMQIMTRVNH 251
Score = 54.4 bits (125), Expect = 3e-06
Identities = 26/60 (43%), Positives = 39/60 (65%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+QSLCE L + D++ ++T V +VA FES++ + +KQ+PCI SMLT+
Sbjct: 223 SWFIQSLCEMLEKFSKTLDLMQIMTRVNHKVATHFESSS-NAPGFSGKKQIPCIVSMLTK 281
>UniRef50_A1L2P4 Cluster: LOC100036910 protein; n=1; Xenopus
laevis|Rep: LOC100036910 protein - Xenopus laevis
(African clawed frog)
Length = 235
Score = 74.1 bits (174), Expect = 4e-12
Identities = 35/67 (52%), Positives = 43/67 (64%)
Frame = +3
Query: 27 NLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLI 206
NL F D+C TL GKPK+FFIQAC+G +LD GI + G +RIP+ ADFL
Sbjct: 149 NLTDLFRGDRCKTLVGKPKIFFIQACRGTELDSGIETDSGSEPG--EETHRIPVEADFLY 206
Query: 207 VFSTVPG 227
+STVPG
Sbjct: 207 AYSTVPG 213
>UniRef50_UPI0000519DFF Cluster: PREDICTED: similar to Caspase
precursor (drICE); n=1; Apis mellifera|Rep: PREDICTED:
similar to Caspase precursor (drICE) - Apis mellifera
Length = 280
Score = 72.9 bits (171), Expect = 8e-12
Identities = 37/85 (43%), Positives = 52/85 (61%), Gaps = 1/85 (1%)
Frame = +3
Query: 3 HETHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGIT-LSNTETDGXXXXXYR 179
++ Y +W F +D C +LAGKPKLFFIQAC+G D GI S ++D Y
Sbjct: 129 YDISYPVQMIWQPFNSDNCISLAGKPKLFFIQACRGVTSDSGIQGRSGIDSD---EMTYV 185
Query: 180 IPIHADFLIVFSTVPGYYSWRNTTR 254
+P+ ADFL +ST+ G YS+R+T +
Sbjct: 186 LPMTADFLYAYSTMEGCYSFRDTNK 210
Score = 44.4 bits (100), Expect = 0.003
Identities = 21/63 (33%), Positives = 37/63 (58%)
Frame = +2
Query: 248 NSCSWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSM 427
N SW++Q+LC+ + + D+L +LT ++VA ++ S+ D ++KQ+P S
Sbjct: 209 NKGSWYIQTLCKVINEHWKNYDMLKMLTITLRKVATEY-SSQHDEMDKDKKKQMPTFTST 267
Query: 428 LTR 436
LTR
Sbjct: 268 LTR 270
>UniRef50_Q2TM51 Cluster: Caspase; n=3; Penaeidae|Rep: Caspase -
Fenneropenaeus merguiensis (Banana prawn) (Penaeus
merguiensis)
Length = 320
Score = 70.5 bits (165), Expect = 4e-11
Identities = 33/84 (39%), Positives = 54/84 (64%), Gaps = 7/84 (8%)
Frame = +3
Query: 30 LWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSN------TETDG-XXXXXYRIPI 188
LW FTA++C +LAGKPKL+FIQAC+G +D G+ +S +TD Y IP+
Sbjct: 168 LWINFTAERCASLAGKPKLYFIQACRGLDVDKGVNMSRAVRGMAVQTDNIGSTEEYVIPV 227
Query: 189 HADFLIVFSTVPGYYSWRNTTRAL 260
HAD L+++++ PG+ ++ + + +
Sbjct: 228 HADQLVMWASYPGFPAFTSNRKGI 251
>UniRef50_UPI0000F2097E Cluster: PREDICTED: hypothetical protein;
n=3; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 266
Score = 66.9 bits (156), Expect = 5e-10
Identities = 29/67 (43%), Positives = 41/67 (61%)
Frame = +3
Query: 45 TADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTVP 224
T+D CP+L KPK+FF+QAC+G + D G+ + E +P DFL +STV
Sbjct: 127 TSDLCPSLRDKPKIFFLQACRGVEYDPGVEADSVEASEDFFGISDVP-ELDFLCCYSTVE 185
Query: 225 GYYSWRN 245
GY++WRN
Sbjct: 186 GYFAWRN 192
>UniRef50_Q92851-2 Cluster: Isoform B of Q92851 ; n=9; Mammalia|Rep:
Isoform B of Q92851 - Homo sapiens (Human)
Length = 479
Score = 65.3 bits (152), Expect = 2e-09
Identities = 34/73 (46%), Positives = 46/73 (63%), Gaps = 4/73 (5%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS----NTETDGXXXXXYRIPIHADFLI 206
+FTA +CP LA KPKLFFIQACQG+++ +++ N E IP ADFL+
Sbjct: 337 HFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE-QAPTSLQDSIPAEADFLL 395
Query: 207 VFSTVPGYYSWRN 245
+TVPGY S+R+
Sbjct: 396 GLATVPGYVSFRH 408
>UniRef50_Q6KF63 Cluster: Caspase 10; n=3; Catarrhini|Rep: Caspase
10 - Homo sapiens (Human)
Length = 455
Score = 65.3 bits (152), Expect = 2e-09
Identities = 34/73 (46%), Positives = 46/73 (63%), Gaps = 4/73 (5%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS----NTETDGXXXXXYRIPIHADFLI 206
+FTA +CP LA KPKLFFIQACQG+++ +++ N E IP ADFL+
Sbjct: 313 HFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE-QAPTSLQDSIPAEADFLL 371
Query: 207 VFSTVPGYYSWRN 245
+TVPGY S+R+
Sbjct: 372 GLATVPGYVSFRH 384
>UniRef50_Q92851 Cluster: Caspase-10 precursor (EC 3.4.22.63)
(CASP-10) (ICE-like apoptotic protease 4) (Apoptotic
protease Mch-4) (FAS-associated death domain protein
interleukin-1B-converting enzyme 2) (FLICE2) [Contains:
Caspase-10 subunit p23/17; Caspase-10 subunit p12]; n=9;
Eutheria|Rep: Caspase-10 precursor (EC 3.4.22.63)
(CASP-10) (ICE-like apoptotic protease 4) (Apoptotic
protease Mch-4) (FAS-associated death domain protein
interleukin-1B-converting enzyme 2) (FLICE2) [Contains:
Caspase-10 subunit p23/17; Caspase-10 subunit p12] -
Homo sapiens (Human)
Length = 521
Score = 65.3 bits (152), Expect = 2e-09
Identities = 34/73 (46%), Positives = 46/73 (63%), Gaps = 4/73 (5%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS----NTETDGXXXXXYRIPIHADFLI 206
+FTA +CP LA KPKLFFIQACQG+++ +++ N E IP ADFL+
Sbjct: 380 HFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE-QAPTSLQDSIPAEADFLL 438
Query: 207 VFSTVPGYYSWRN 245
+TVPGY S+R+
Sbjct: 439 GLATVPGYVSFRH 451
>UniRef50_Q3HL92 Cluster: Caspase-like protein; n=6; Eumetazoa|Rep:
Caspase-like protein - Aiptasia pallida (Sea anemone)
Length = 415
Score = 64.9 bits (151), Expect = 2e-09
Identities = 30/65 (46%), Positives = 39/65 (60%)
Frame = +3
Query: 54 KCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTVPGYY 233
K L GKPK+F QACQG + G+ ++ +IP+ ADFL +STVPGYY
Sbjct: 279 KGTNLVGKPKIFIFQACQGHEYMDGVDATDAPP---ADKRVQIPVEADFLYAYSTVPGYY 335
Query: 234 SWRNT 248
SWRN+
Sbjct: 336 SWRNS 340
Score = 38.7 bits (86), Expect = 0.16
Identities = 23/60 (38%), Positives = 34/60 (56%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+QS+ E Y D+LT++T V VA +S T D ++KQ+P I SM+ +
Sbjct: 344 SWFIQSIAEVFDKYAKTTDLLTMMTRVNALVA-THQSRTND-PYSDRKKQIPSIVSMMRK 401
>UniRef50_Q7QKT2 Cluster: ENSANGP00000015505; n=3; Anopheles gambiae
str. PEST|Rep: ENSANGP00000015505 - Anopheles gambiae
str. PEST
Length = 263
Score = 64.5 bits (150), Expect = 3e-09
Identities = 30/75 (40%), Positives = 46/75 (61%), Gaps = 2/75 (2%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG--XXXXXYRIPIHAD 197
D LW F +KCP+L GKPKL FIQ+C+G KLD G +++ + +IP++AD
Sbjct: 119 DELWTNFVGNKCPSLIGKPKLVFIQSCRGGKLDYGASIATADARPGLEEPVDVKIPMYAD 178
Query: 198 FLIVFSTVPGYYSWR 242
L+++S+ + S R
Sbjct: 179 LLVMYSSFEHHSSIR 193
>UniRef50_UPI0000E49D20 Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 329
Score = 63.3 bits (147), Expect = 7e-09
Identities = 46/135 (34%), Positives = 71/135 (52%), Gaps = 11/135 (8%)
Frame = +3
Query: 30 LWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXY----------- 176
L+ +F +KCPTL GKPKLF IQAC+GD+ + G+ TD
Sbjct: 176 LFEFFRGEKCPTLIGKPKLFLIQACRGDRHEIGVDPPVDVTDSAAPEDEWVTVTDSGTRP 235
Query: 177 RIPIHADFLIVFSTVPGYYSWRNTTRALGLCNLFVKN*ETMVLKEIFLHS*HLFVRELL* 356
IP AD L+ +S V GYYS R+T A G + +++ + K + LH + + E+L
Sbjct: 236 TIPAAADMLLSYSVVQGYYSHRDT--AFG--SWYIQ----ALAKVLALHGTTMEITEILT 287
Query: 357 ILSQIHQISHRCINK 401
+++Q+ IS R + +
Sbjct: 288 LVNQL--ISQRAVER 300
Score = 40.3 bits (90), Expect = 0.053
Identities = 23/60 (38%), Positives = 34/60 (56%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SW++Q+L + L +GT +I +LT V Q ++ D M +KQ+PC SMLTR
Sbjct: 263 SWYIQALAKVLALHGTTMEITEILTLVNQLISQRAVERCLD-PRMVGKKQMPCYMSMLTR 321
>UniRef50_Q4RG79 Cluster: Chromosome 2 SCAF15106, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 2 SCAF15106, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 242
Score = 63.3 bits (147), Expect = 7e-09
Identities = 41/106 (38%), Positives = 50/106 (47%), Gaps = 28/106 (26%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQ--------------------ACQGDKLDGGITLS----NTE 149
F D C +L GKPKLFFIQ AC+G + D GI N
Sbjct: 83 FRGDMCKSLVGKPKLFFIQFSAETATQDHNEMSSHLLHQACRGSEFDDGIQTDSGPPNDT 142
Query: 150 TDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTR----ALGLCNL 275
+ ++IP+ ADFL +STVPGYYSWRN R LCN+
Sbjct: 143 METDANPRHKIPVEADFLFAYSTVPGYYSWRNPGRGSWFVQALCNV 188
Score = 56.0 bits (129), Expect = 1e-06
Identities = 27/60 (45%), Positives = 39/60 (65%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+Q+LC L +G Q +I+ +LT V VA FES + D ++KQ+PC+ SMLT+
Sbjct: 179 SWFVQALCNVLNEFGKQLEIMQILTRVNYMVATSFESWSED-PRFSEKKQIPCVVSMLTK 237
>UniRef50_A7SPA7 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 242
Score = 62.9 bits (146), Expect = 9e-09
Identities = 32/70 (45%), Positives = 40/70 (57%), Gaps = 2/70 (2%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNT-ETDGXXXXXYRI-PIHADFLIVFS 215
F + CPTLA KPKLFFIQAC+G D GI T + D P + FL+ ++
Sbjct: 110 FKGNACPTLAHKPKLFFIQACRGQDFDRGIQADATRDMDASDAVRQNAEPNESHFLLGYA 169
Query: 216 TVPGYYSWRN 245
T PGY SWR+
Sbjct: 170 TPPGYVSWRS 179
>UniRef50_A7S4V9 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 358
Score = 61.7 bits (143), Expect = 2e-08
Identities = 29/68 (42%), Positives = 39/68 (57%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTV 221
F + L GKPKLFF+QAC+G D G + ++ +P ADFLI ++TV
Sbjct: 226 FNGYQAKDLIGKPKLFFLQACRGGDFDHGARMEQIDSPTDKSS---LPSEADFLIAYATV 282
Query: 222 PGYYSWRN 245
PGY SWR+
Sbjct: 283 PGYVSWRH 290
Score = 40.7 bits (91), Expect = 0.040
Identities = 23/60 (38%), Positives = 37/60 (61%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+Q+L E + T D+L++L V ++VAL+FES +++KQ+P MLT+
Sbjct: 295 SWFIQALVEVFKTDATTEDVLSMLIKVNRKVALEFES-------FNRKKQMPSPVVMLTK 347
>UniRef50_Q14790 Cluster: Caspase-8 precursor (EC 3.4.22.61)
(CASP-8) (ICE-like apoptotic protease 5)
(MORT1-associated CED-3 homolog) (MACH) (FADD-homologous
ICE/CED-3-like protease) (FADD-like ICE) (FLICE)
(Apoptotic cysteine protease) (Apoptotic protease Mch-5)
(CAP4) [Contains: Caspase-8 subunit p18; Caspase-8
subunit p10]; n=35; Amniota|Rep: Caspase-8 precursor (EC
3.4.22.61) (CASP-8) (ICE-like apoptotic protease 5)
(MORT1-associated CED-3 homolog) (MACH) (FADD-homologous
ICE/CED-3-like protease) (FADD-like ICE) (FLICE)
(Apoptotic cysteine protease) (Apoptotic protease Mch-5)
(CAP4) [Contains: Caspase-8 subunit p18; Caspase-8
subunit p10] - Homo sapiens (Human)
Length = 479
Score = 60.9 bits (141), Expect = 4e-08
Identities = 35/75 (46%), Positives = 41/75 (54%), Gaps = 7/75 (9%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSN-------TETDGXXXXXYRIPIHADF 200
FT KCP+LAGKPK+FFIQACQGD GI + E D IP ADF
Sbjct: 340 FTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADF 399
Query: 201 LIVFSTVPGYYSWRN 245
L+ +TV S+RN
Sbjct: 400 LLGMATVNNCVSYRN 414
>UniRef50_UPI00015553DC Cluster: PREDICTED: similar to caspase-15;
n=1; Ornithorhynchus anatinus|Rep: PREDICTED: similar to
caspase-15 - Ornithorhynchus anatinus
Length = 237
Score = 60.5 bits (140), Expect = 5e-08
Identities = 30/76 (39%), Positives = 42/76 (55%), Gaps = 2/76 (2%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNT--ETDGXXXXXYRIPIHAD 197
+ ++ F CP L KPK+F IQAC+GD+ DGG+ + E R+P +D
Sbjct: 93 EEIFKLFNNANCPNLREKPKIFIIQACRGDRTDGGVEAFDNVPEEMDDTSNVKRLPTTSD 152
Query: 198 FLIVFSTVPGYYSWRN 245
F IV+ST G+ S RN
Sbjct: 153 FFIVYSTQKGHVSVRN 168
>UniRef50_Q9I8J3 Cluster: Caspase-8; n=11; Danio rerio|Rep:
Caspase-8 - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 476
Score = 60.5 bits (140), Expect = 5e-08
Identities = 35/77 (45%), Positives = 43/77 (55%), Gaps = 11/77 (14%)
Frame = +3
Query: 57 CPTLAGKPKLFFIQACQGDKLDGGITLSN-----------TETDGXXXXXYRIPIHADFL 203
C TLA KPKLFFIQACQGD+ G+ S+ E D +IPI ADFL
Sbjct: 340 CRTLASKPKLFFIQACQGDENQAGVWTSDGREDAPEEDEEYEEDAGIIVLRKIPIEADFL 399
Query: 204 IVFSTVPGYYSWRNTTR 254
I +TV Y S+R+T +
Sbjct: 400 IGMATVEHYLSYRHTKK 416
>UniRef50_UPI0000E48C15 Cluster: PREDICTED: similar to caspase 8;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to caspase 8 - Strongylocentrotus purpuratus
Length = 300
Score = 60.1 bits (139), Expect = 6e-08
Identities = 40/114 (35%), Positives = 56/114 (49%), Gaps = 4/114 (3%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFL 203
D L F D P+L KPKLFFIQACQG+ G + + T +P ++D L
Sbjct: 161 DALTGLFRGDYVPSLVNKPKLFFIQACQGNDAQGAVDIQQDAT-----ATATLPHNSDTL 215
Query: 204 IVFSTVPGYYSWRNTTRA----LGLCNLFVKN*ETMVLKEIFLHS*HLFVRELL 353
+ +T+PGY S+RN + LCN+ T K++ L S V EL+
Sbjct: 216 VSHATIPGYASFRNAYSGSLFIISLCNII----NTHYKKKVDLLSMLTMVNELM 265
>UniRef50_Q0WYJ4 Cluster: Caspase 10; n=4; Percomorpha|Rep: Caspase
10 - Paralichthys olivaceus (Japanese flounder)
Length = 494
Score = 59.7 bits (138), Expect = 8e-08
Identities = 36/86 (41%), Positives = 45/86 (52%), Gaps = 7/86 (8%)
Frame = +3
Query: 18 KPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXY------- 176
K ++L A CPTLA KPKLFFIQACQG K + + E DG
Sbjct: 340 KINDLMEPLNAHNCPTLAQKPKLFFIQACQGKKGQSAVYI---EADGPATSLICTDAVRD 396
Query: 177 RIPIHADFLIVFSTVPGYYSWRNTTR 254
P+ ADFLI +TVP + S+R+ R
Sbjct: 397 SFPVDADFLISMATVPSFVSYRDKQR 422
>UniRef50_Q09HM6 Cluster: Caspase-8; n=1; Molgula tectiformis|Rep:
Caspase-8 - Molgula tectiformis
Length = 700
Score = 59.7 bits (138), Expect = 8e-08
Identities = 37/104 (35%), Positives = 52/104 (50%), Gaps = 5/104 (4%)
Frame = +3
Query: 15 YKPDNLWYYFTADKCPTLAGKPKLFFIQACQG-DKLDGGITL----SNTETDGXXXXXYR 179
++ ++ +FT C TL KPKL FIQAC G ++++G S+ +DG
Sbjct: 530 FRISDIQSFFTTTTCSTLQDKPKLVFIQACAGANEMEGKEIQCQQESDIHSDGDDNIKEA 589
Query: 180 IPIHADFLIVFSTVPGYYSWRNTTRALGLCNLFVKN*ETMVLKE 311
P ADFL+ ST PGY S+R+T VKN + KE
Sbjct: 590 TPFLADFLLANSTWPGYRSYRSTKTGSWFITALVKNLKMYSCKE 633
>UniRef50_A7SXL6 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 180
Score = 59.3 bits (137), Expect = 1e-07
Identities = 32/76 (42%), Positives = 39/76 (51%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFL 203
D + F CP LA KPKLFFIQAC+GD +D G + +P ADFL
Sbjct: 24 DEITGKFQGTNCPQLATKPKLFFIQACRGDDVDKGYR-GHRNHHHEEELPVTLPSEADFL 82
Query: 204 IVFSTVPGYYSWRNTT 251
I +ST G S+R T
Sbjct: 83 IAYSTTKGKVSFRRYT 98
>UniRef50_A7S119 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 229
Score = 58.8 bits (136), Expect = 1e-07
Identities = 27/74 (36%), Positives = 45/74 (60%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFL 203
++L F CP+L GKPK+FF+QAC+G K + + ++++ +P +DFL
Sbjct: 95 ESLTNKFRGSTCPSLQGKPKVFFLQACRGAKKE--LVAVESDSEPVPIRHSGLPSDSDFL 152
Query: 204 IVFSTVPGYYSWRN 245
I +++ PGY S+RN
Sbjct: 153 ICYASSPGYESYRN 166
>UniRef50_Q9NHF9 Cluster: Caspase 6-like protein BG2; n=3;
Sophophora|Rep: Caspase 6-like protein BG2 - Drosophila
melanogaster (Fruit fly)
Length = 308
Score = 58.4 bits (135), Expect = 2e-07
Identities = 32/87 (36%), Positives = 42/87 (48%), Gaps = 10/87 (11%)
Frame = +3
Query: 15 YKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSN----------TETDGXX 164
Y + LW F D C TL KPKLFFIQAC+G L+ + S+
Sbjct: 142 YPVERLWNPFLGDNCKTLKNKPKLFFIQACRGANLEKAVEFSSFAVMTRELVPEPAAAVQ 201
Query: 165 XXXYRIPIHADFLIVFSTVPGYYSWRN 245
Y IP AD L+ +ST ++S+RN
Sbjct: 202 PITYAIPSTADILVFYSTFDKFFSFRN 228
Score = 39.9 bits (89), Expect = 0.070
Identities = 24/67 (35%), Positives = 38/67 (56%), Gaps = 7/67 (10%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQR-------DILTLLTFVCQRVALDFESNTPDITPMHQQKQVPC 415
SWF+QSLC L ++L LLT V ++VA +++SNT + ++Q K++P
Sbjct: 233 SWFIQSLCRVLDQAAANEAATPEGVELLRLLTAVNRKVAYEYQSNTKN-EALNQMKEMPN 291
Query: 416 INSMLTR 436
S LT+
Sbjct: 292 FMSTLTK 298
>UniRef50_A2BGE2 Cluster: Novel protein similar to caspase 8; n=4;
Danio rerio|Rep: Novel protein similar to caspase 8 -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 366
Score = 57.6 bits (133), Expect = 3e-07
Identities = 31/80 (38%), Positives = 45/80 (56%), Gaps = 4/80 (5%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSN----TETDGXXXXXYRIPIH 191
D++ F C +LAGKPK+FFIQAC+G ++ + +++ + T IP
Sbjct: 221 DDITSPFNGANCSSLAGKPKVFFIQACRGHEIQSKVMVADGSGGSRTQKPGRVSVSIPKD 280
Query: 192 ADFLIVFSTVPGYYSWRNTT 251
+DFLI STV GY S R+ T
Sbjct: 281 SDFLIARSTVEGYVSIRDRT 300
>UniRef50_UPI0000E472FD Cluster: PREDICTED: similar to caspase 8;
n=2; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to caspase 8 - Strongylocentrotus purpuratus
Length = 790
Score = 56.8 bits (131), Expect = 6e-07
Identities = 36/104 (34%), Positives = 48/104 (46%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTV 221
F D P+L KPKLFFIQACQG + G + + T +P +D L+ STV
Sbjct: 663 FRGDYVPSLVNKPKLFFIQACQGREAQGAVDIQQDAT-------ATLPNESDTLVSMSTV 715
Query: 222 PGYYSWRNTTRALGLCNLFVKN*ETMVLKEIFLHS*HLFVRELL 353
PGY S R+ ++ T K + L S V E+L
Sbjct: 716 PGYASNRSVSQGTWFITALCSIINTYYKKNVDLLSMLTLVNEML 759
Score = 50.8 bits (116), Expect = 4e-05
Identities = 29/77 (37%), Positives = 39/77 (50%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFL 203
D L F + P+L KPKLFFIQACQGD + + T +P +D L
Sbjct: 529 DALTGLFRGEYVPSLVNKPKLFFIQACQGDNAQRAVDIQQDATT-------TLPNESDTL 581
Query: 204 IVFSTVPGYYSWRNTTR 254
+ STV GY S R+ ++
Sbjct: 582 VSMSTVSGYASNRSVSQ 598
>UniRef50_P55212 Cluster: Caspase-6 precursor (EC 3.4.22.59)
(CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6
subunit p18; Caspase-6 subunit p11]; n=35;
Euteleostomi|Rep: Caspase-6 precursor (EC 3.4.22.59)
(CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6
subunit p18; Caspase-6 subunit p11] - Homo sapiens
(Human)
Length = 293
Score = 56.0 bits (129), Expect = 1e-06
Identities = 31/80 (38%), Positives = 41/80 (51%), Gaps = 11/80 (13%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGI-----------TLSNTETDGXXXXXYRIPI 188
F DKC +L GKPK+F IQAC+G++ D + L T+ Y +P
Sbjct: 143 FKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPA 202
Query: 189 HADFLIVFSTVPGYYSWRNT 248
ADFL+ +S GYYS R T
Sbjct: 203 GADFLMCYSVAEGYYSHRET 222
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/60 (40%), Positives = 35/60 (58%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SW++Q LCE L YG+ + LLT V ++V+ D + + +KQVPC SMLT+
Sbjct: 226 SWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAI-GKKQVPCFASMLTK 284
>UniRef50_UPI0000ECB87F Cluster: Caspase-10 precursor (EC 3.4.22.63)
(CASP-10) (ICE-like apoptotic protease 4) (Apoptotic
protease Mch-4) (FAS-associated death domain protein
interleukin-1B-converting enzyme 2) (FLICE2) [Contains:
Caspase-10 subunit p23/17; Caspase-10 subunit p12].;
n=2; Gallus gallus|Rep: Caspase-10 precursor (EC
3.4.22.63) (CASP-10) (ICE-like apoptotic protease 4)
(Apoptotic protease Mch-4) (FAS-associated death domain
protein interleukin-1B-converting enzyme 2) (FLICE2)
[Contains: Caspase-10 subunit p23/17; Caspase-10 subunit
p12]. - Gallus gallus
Length = 537
Score = 55.2 bits (127), Expect = 2e-06
Identities = 29/76 (38%), Positives = 41/76 (53%), Gaps = 7/76 (9%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSN-------TETDGXXXXXYRIPIHAD 197
YFTA +CP L KPKLFF+QACQG ++ + + + IP AD
Sbjct: 390 YFTAKQCPQLTEKPKLFFVQACQGKEVQRPVYVETDARVPDFSSVPQSTSPSESIPEEAD 449
Query: 198 FLIVFSTVPGYYSWRN 245
FL+ +T+ GY S+R+
Sbjct: 450 FLLGMATIDGYASFRH 465
>UniRef50_Q5C0Y4 Cluster: SJCHGC07329 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC07329 protein - Schistosoma
japonicum (Blood fluke)
Length = 239
Score = 55.2 bits (127), Expect = 2e-06
Identities = 31/101 (30%), Positives = 49/101 (48%), Gaps = 10/101 (9%)
Frame = +3
Query: 12 HYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLD----------GGITLSNTETDGX 161
H D L FT +CP LAGKPK IQAC+G++ + + ++ E
Sbjct: 87 HVSIDELVSCFTNKRCPLLAGKPKFILIQACRGEERNHNDSKMGDFLDSLPSNSREISLD 146
Query: 162 XXXXYRIPIHADFLIVFSTVPGYYSWRNTTRALGLCNLFVK 284
+P +D +I ++T+PG+ SWR+ T +FV+
Sbjct: 147 PSSWLSLPHMSDCVIAYTTLPGFVSWRSETEGSWYVKVFVE 187
>UniRef50_Q16FR8 Cluster: Caspase-1; n=1; Aedes aegypti|Rep:
Caspase-1 - Aedes aegypti (Yellowfever mosquito)
Length = 283
Score = 55.2 bits (127), Expect = 2e-06
Identities = 32/79 (40%), Positives = 44/79 (55%), Gaps = 8/79 (10%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITL------SNTETD--GXXXXXYRIPIHA 194
+FT ++AGKPKLF +QAC+G KLD G+ L ++ D Y P A
Sbjct: 137 HFTPTALKSMAGKPKLFIVQACRGRKLDRGVQLRAKLIQADCAKDVVDSQSVVYTYPEFA 196
Query: 195 DFLIVFSTVPGYYSWRNTT 251
D L+V S+ G+YS+RN T
Sbjct: 197 DLLLVMSSHHGHYSFRNET 215
>UniRef50_UPI0000F2DFE7 Cluster: PREDICTED: similar to apoptotic
cysteine protease proMch4; n=1; Monodelphis
domestica|Rep: PREDICTED: similar to apoptotic cysteine
protease proMch4 - Monodelphis domestica
Length = 452
Score = 54.8 bits (126), Expect = 2e-06
Identities = 30/76 (39%), Positives = 39/76 (51%), Gaps = 4/76 (5%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYR----IPIHADFLI 206
YF A +CP LA KPKLFF QACQG + + L IP+ ADFL+
Sbjct: 310 YFKAHRCPGLANKPKLFFFQACQGPDIQESMLLEEDAKISPPIQVETPQRYIPVEADFLL 369
Query: 207 VFSTVPGYYSWRNTTR 254
+TV G + R+T +
Sbjct: 370 GMATVDGCCAIRHTIK 385
>UniRef50_A5JSK5 Cluster: Cysteine protease; n=2; Eukaryota|Rep:
Cysteine protease - Oryzias latipes (Medaka fish)
(Japanese ricefish)
Length = 319
Score = 54.8 bits (126), Expect = 2e-06
Identities = 27/68 (39%), Positives = 39/68 (57%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTV 221
F A + L GKPK+F IQACQG ++ G+ L++ E D IP AD L+ +TV
Sbjct: 186 FKASEQSALTGKPKMFLIQACQGGQIHKGVALTDVEAD--DCSTQTIPEEADILVALATV 243
Query: 222 PGYYSWRN 245
Y ++R+
Sbjct: 244 EDYPAYRH 251
>UniRef50_Q16PQ5 Cluster: Ecdysone-inducible caspase, putative; n=2;
Culicidae|Rep: Ecdysone-inducible caspase, putative -
Aedes aegypti (Yellowfever mosquito)
Length = 449
Score = 54.8 bits (126), Expect = 2e-06
Identities = 32/74 (43%), Positives = 41/74 (55%), Gaps = 6/74 (8%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLD-GGITLS-NTETDG----XXXXXYRIPIHADFL 203
F CP L +PKLFF C+GD D G + L+ +TE DG +P +AD L
Sbjct: 307 FNNANCPKLIRRPKLFFFSICRGDNPDYGTLRLAEHTERDGMINLKKDPPTNMPTYADML 366
Query: 204 IVFSTVPGYYSWRN 245
I FSTVPGY + R+
Sbjct: 367 ICFSTVPGYAAHRD 380
>UniRef50_UPI0000586459 Cluster: PREDICTED: similar to caspase-3,
partial; n=10; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to caspase-3, partial -
Strongylocentrotus purpuratus
Length = 437
Score = 54.4 bits (125), Expect = 3e-06
Identities = 21/30 (70%), Positives = 26/30 (86%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGI 131
F +D+CPTL GKPKLFF+QAC+G KLD G+
Sbjct: 261 FCSDRCPTLNGKPKLFFLQACRGKKLDDGV 290
Score = 39.5 bits (88), Expect = 0.093
Identities = 21/60 (35%), Positives = 37/60 (61%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SWF+Q+L E + + + D+L+++T V +VA FES++ + KQ+P +MLT+
Sbjct: 375 SWFIQALTETILQHAGEEDLLSMITMVNGKVARAFESSS------GRHKQMPAPVTMLTK 428
Score = 38.3 bits (85), Expect = 0.21
Identities = 14/35 (40%), Positives = 21/35 (60%)
Frame = +3
Query: 150 TDGXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTR 254
TD ++P +D L+ ++TVPG+ SWRN R
Sbjct: 339 TDSFASSRSKVPSQSDMLLAYATVPGFVSWRNAER 373
>UniRef50_Q8I749 Cluster: Caspase-related protein; n=1; Suberites
domuncula|Rep: Caspase-related protein - Suberites
domuncula (Sponge)
Length = 496
Score = 54.4 bits (125), Expect = 3e-06
Identities = 35/90 (38%), Positives = 46/90 (51%), Gaps = 13/90 (14%)
Frame = +3
Query: 57 CPTLAGKPKLFFIQACQGDKLDGGI---TLSNTETD------GXXXXXYRIPIHADFLIV 209
CPTL GKPK+FF+QAC+GD G +S TE D G IP ADF
Sbjct: 359 CPTLRGKPKIFFVQACRGDIESMGFKNEEVSKTEDDLQADMPGGHLHTDTIPQEADFFYG 418
Query: 210 FSTVPGYYSWRNTTRA----LGLCNLFVKN 287
F+T GY ++R+ LC +F+K+
Sbjct: 419 FATPLGYAAYRSRRHGSWYISELCQVFIKH 448
>UniRef50_A7S9L1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 262
Score = 54.4 bits (125), Expect = 3e-06
Identities = 34/82 (41%), Positives = 47/82 (57%), Gaps = 13/82 (15%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLD-GGITLSNTET-DGXXXXXYRIPIH-------- 191
F+ +C +LAGKPKLFFIQAC+G+K D G I +T + Y+ +
Sbjct: 116 FSNARCRSLAGKPKLFFIQACRGEKKDFGTIVQDGPKTPEEHQETPYKFDLSPHNKGAST 175
Query: 192 ---ADFLIVFSTVPGYYSWRNT 248
ADFL+ +STV G+ S+RNT
Sbjct: 176 AEMADFLLAYSTVGGHASFRNT 197
>UniRef50_Q9IB64 Cluster: Caspase-8; n=1; Xenopus laevis|Rep:
Caspase-8 - Xenopus laevis (African clawed frog)
Length = 500
Score = 54.0 bits (124), Expect = 4e-06
Identities = 31/73 (42%), Positives = 39/73 (53%), Gaps = 4/73 (5%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQG----DKLDGGITLSNTETDGXXXXXYRIPIHADFLI 206
YF C +L KPK+FFIQACQG K+D + S E D +P+ ADFL
Sbjct: 363 YFNGQHCRSLINKPKIFFIQACQGKESHPKVDMDMDTSFYEPDANGS---HLPLEADFLT 419
Query: 207 VFSTVPGYYSWRN 245
F+TV Y S R+
Sbjct: 420 AFATVEDYTSLRH 432
>UniRef50_Q9IB62 Cluster: Caspase-10; n=5; Xenopus|Rep: Caspase-10 -
Xenopus laevis (African clawed frog)
Length = 520
Score = 53.6 bits (123), Expect = 5e-06
Identities = 34/90 (37%), Positives = 42/90 (46%), Gaps = 2/90 (2%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXY--RIPIHADFLIVF 212
YFTA C +L KPKLFFIQACQG + + Y +P ADFL+
Sbjct: 371 YFTATSCISLTLKPKLFFIQACQGIYTHPSSKVEPDASVPVEHKKYIVNVPKEADFLLGM 430
Query: 213 STVPGYYSWRNTTRALGLCNLFVKN*ETMV 302
STV GY ++R+ KN MV
Sbjct: 431 STVDGYAAYRHKKYGSWYIQALCKNLVEMV 460
>UniRef50_Q5D0W5 Cluster: Caspase 3C; n=2; Hydra vulgaris|Rep:
Caspase 3C - Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 326
Score = 53.2 bits (122), Expect = 7e-06
Identities = 28/62 (45%), Positives = 34/62 (54%), Gaps = 2/62 (3%)
Frame = +3
Query: 66 LAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXX--YRIPIHADFLIVFSTVPGYYSW 239
LAGKPKLF IQAC+G K I + G + + +DFL +STV YYSW
Sbjct: 189 LAGKPKLFLIQACRGTKYMESIDTVDGFGPGLSNESNVLDVTVESDFLYAYSTVQSYYSW 248
Query: 240 RN 245
RN
Sbjct: 249 RN 250
>UniRef50_UPI0001554FA5 Cluster: PREDICTED: similar to initiator
caspase, partial; n=1; Ornithorhynchus anatinus|Rep:
PREDICTED: similar to initiator caspase, partial -
Ornithorhynchus anatinus
Length = 480
Score = 52.8 bits (121), Expect = 9e-06
Identities = 27/70 (38%), Positives = 39/70 (55%), Gaps = 3/70 (4%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTE---TDGXXXXXYRIPIHADFLIVF 212
FT+ C TLA KPK+FF+QACQG + GG++L E + +P AD L+
Sbjct: 334 FTSSACRTLATKPKIFFVQACQGGQGQGGLSLRGREGALLEADAVVIPSVPDWADLLVGM 393
Query: 213 STVPGYYSWR 242
+TV + +R
Sbjct: 394 ATVEDFICFR 403
>UniRef50_Q2HZ04 Cluster: ICE-5; n=3; Bombyx mori|Rep: ICE-5 -
Bombyx mori (Silk moth)
Length = 312
Score = 52.8 bits (121), Expect = 9e-06
Identities = 26/53 (49%), Positives = 34/53 (64%)
Frame = +3
Query: 63 TLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTV 221
TL GKPK+FFIQAC+G +D G T+ DG R+P H+DFL + S+V
Sbjct: 158 TLVGKPKIFFIQACRGPFMDEGRTV---VLDGESRSVLRLPTHSDFLFLHSSV 207
Score = 36.3 bits (80), Expect = 0.86
Identities = 18/60 (30%), Positives = 32/60 (53%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SW +Q+LCE +R + D+L ++T V + +A + TP + +KQ+ LT+
Sbjct: 247 SWLIQTLCEIIRKNHKEIDLLHMITMVNKSIAYAKSTYTPKCQETNNKKQMSETRFTLTK 306
>UniRef50_UPI00015B57F0 Cluster: PREDICTED: similar to GA20532-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
GA20532-PA - Nasonia vitripennis
Length = 1390
Score = 52.4 bits (120), Expect = 1e-05
Identities = 32/90 (35%), Positives = 47/90 (52%), Gaps = 6/90 (6%)
Frame = +3
Query: 63 TLAGKPKLFFIQACQGDKLDGGI------TLSNTETDGXXXXXYRIPIHADFLIVFSTVP 224
+L KPK+FFIQAC+G ++D GI T S E DG ++ I AD +S+ P
Sbjct: 290 SLINKPKIFFIQACRGPQIDKGICSNEVNTSSEDEVDGNEVFT-KVSIKADIFKAYSSPP 348
Query: 225 GYYSWRNTTRALGLCNLFVKN*ETMVLKEI 314
+ SW+ + +C F K +T L+ I
Sbjct: 349 DFVSWQASLFIREVCKSFNKYGKTADLETI 378
>UniRef50_Q4JQQ0 Cluster: Initiator caspase; n=2; Gallus gallus|Rep:
Initiator caspase - Gallus gallus (Chicken)
Length = 464
Score = 52.4 bits (120), Expect = 1e-05
Identities = 30/73 (41%), Positives = 40/73 (54%), Gaps = 5/73 (6%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITL-----SNTETDGXXXXXYRIPIHADFLI 206
F+ CP+LAGKPKLFFIQACQG +T+ + ETD IP AD L+
Sbjct: 321 FSGSNCPSLAGKPKLFFIQACQGSVGHPAVTVKEDCSGHLETDA--IPALSIPDQADVLV 378
Query: 207 VFSTVPGYYSWRN 245
+TV + +R+
Sbjct: 379 GMATVEDFECYRS 391
>UniRef50_P31944 Cluster: Caspase-14 precursor (EC 3.4.22.-)
(CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14
subunit 2]; n=14; Mammalia|Rep: Caspase-14 precursor (EC
3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1;
Caspase-14 subunit 2] - Homo sapiens (Human)
Length = 242
Score = 52.4 bits (120), Expect = 1e-05
Identities = 28/77 (36%), Positives = 41/77 (53%), Gaps = 1/77 (1%)
Frame = +3
Query: 18 KPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTE-TDGXXXXXYRIPIHA 194
K +NL+ C L KPK++ IQAC+G++ D G T+ E IP +
Sbjct: 104 KLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYT 163
Query: 195 DFLIVFSTVPGYYSWRN 245
D L V+STV GY ++R+
Sbjct: 164 DALHVYSTVEGYIAYRH 180
>UniRef50_Q8ITP2 Cluster: AmphiCASP-6; n=2; Chordata|Rep:
AmphiCASP-6 - Branchiostoma floridae (Florida lancelet)
(Amphioxus)
Length = 400
Score = 52.0 bits (119), Expect = 2e-05
Identities = 33/81 (40%), Positives = 42/81 (51%), Gaps = 12/81 (14%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQG----------DKLDGGITLSNTETDGXXXXXYR--IP 185
F AD+C +L GKPKLFFIQAC+G D+ DG E R +P
Sbjct: 250 FRADRCTSLKGKPKLFFIQACRGAKHEIPVEPLDEPDGLEGSGEAEPMDMVDAGVRPTLP 309
Query: 186 IHADFLIVFSTVPGYYSWRNT 248
ADFL+ +S G+YS R+T
Sbjct: 310 AGADFLMAYSVSEGFYSHRDT 330
Score = 42.7 bits (96), Expect = 0.010
Identities = 21/60 (35%), Positives = 33/60 (55%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESNTPDITPMHQQKQVPCINSMLTR 436
SW++Q LC L+ +GT ++ +L V + V+ T D + KQ+PC SMLT+
Sbjct: 334 SWYVQDLCAALKQHGTNMEVHQILALVNRMVSCREVERTTDQRSL-GMKQMPCFLSMLTK 392
>UniRef50_Q6E5N8 Cluster: Caspase 8; n=1; Ictalurus punctatus|Rep:
Caspase 8 - Ictalurus punctatus (Channel catfish)
Length = 366
Score = 51.6 bits (118), Expect = 2e-05
Identities = 34/90 (37%), Positives = 46/90 (51%), Gaps = 15/90 (16%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQG-----------DKLDGGITLSNTE----TDG 158
D+++ F+ + CP+L KPK+F IQAC+G D + T + TE +
Sbjct: 209 DDIFGPFSGNSCPSLINKPKVFIIQACRGKEYHLPVEVQPDSYEEEDTEAETEDEKSLET 268
Query: 159 XXXXXYRIPIHADFLIVFSTVPGYYSWRNT 248
IP ADFLI STV GYYS R+T
Sbjct: 269 DAVQMMTIPADADFLIARSTVKGYYSMRDT 298
>UniRef50_UPI00015B59A2 Cluster: PREDICTED: similar to
ecdysone-inducible caspase, putative; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to
ecdysone-inducible caspase, putative - Nasonia
vitripennis
Length = 438
Score = 51.2 bits (117), Expect = 3e-05
Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 9/78 (11%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDK---------LDGGITLSNTETDGXXXXXYRIPIHA 194
FTA +CP+L KPK+F Q C+GDK + +D + ++
Sbjct: 287 FTAMQCPSLINKPKIFIFQTCRGDKHQQAVVSRFATDAVVTKEASSDSHKPFGVSMRNYS 346
Query: 195 DFLIVFSTVPGYYSWRNT 248
D +I ++T+PGY S+R+T
Sbjct: 347 DTIIAYATLPGYVSYRDT 364
>UniRef50_Q4FJK5 Cluster: Casp9 protein; n=20; Eutheria|Rep: Casp9
protein - Mus musculus (Mouse)
Length = 454
Score = 51.2 bits (117), Expect = 3e-05
Identities = 31/90 (34%), Positives = 44/90 (48%), Gaps = 22/90 (24%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG--------XXXXXYR------ 179
F CP+L GKPKLFFIQAC G++ D G ++ T + G Y+
Sbjct: 305 FNGSGCPSLGGKPKLFFIQACGGEQKDHGFEVACTSSQGRTLDSDSEPDAVPYQEGPRPL 364
Query: 180 --------IPIHADFLIVFSTVPGYYSWRN 245
+P +D L+ +ST PG+ SWR+
Sbjct: 365 DQLDAVSSLPTPSDILVSYSTFPGFVSWRD 394
>UniRef50_Q90WU0 Cluster: Caspase 9; n=2; Gallus gallus|Rep: Caspase
9 - Gallus gallus (Chicken)
Length = 403
Score = 50.8 bits (116), Expect = 4e-05
Identities = 31/91 (34%), Positives = 43/91 (47%), Gaps = 22/91 (24%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS-----------NTETDG--------- 158
YF +CP+L GKPKLFFIQAC G++ D G + + E+D
Sbjct: 253 YFNGSQCPSLRGKPKLFFIQACGGEQKDQGFEVDCESPQDETCRRSIESDAIPFQAPSGN 312
Query: 159 --XXXXXYRIPIHADFLIVFSTVPGYYSWRN 245
+P D L+ +ST PG+ SWR+
Sbjct: 313 EDEPDAVASLPTPGDILVSYSTFPGFVSWRD 343
>UniRef50_Q4SC67 Cluster: Chromosome undetermined SCAF14659, whole
genome shotgun sequence; n=2; Deuterostomia|Rep:
Chromosome undetermined SCAF14659, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 445
Score = 50.8 bits (116), Expect = 4e-05
Identities = 34/94 (36%), Positives = 43/94 (45%), Gaps = 25/94 (26%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETD----GXXXXXYRIPI------ 188
Y CP+L GKPKLFFIQAC GD+ D G +S E + G IP+
Sbjct: 262 YLNGQYCPSLQGKPKLFFIQACGGDEKDTGFQVSPDEFEPPVVGADDQTDAIPVSSSSDS 321
Query: 189 ---------------HADFLIVFSTVPGYYSWRN 245
+D L+ +ST PGY SWR+
Sbjct: 322 LSMSDEPDARASLPTSSDILVSYSTFPGYVSWRD 355
>UniRef50_Q3T2L0 Cluster: Caspase-15; n=11; Theria|Rep: Caspase-15 -
Bos taurus (Bovine)
Length = 368
Score = 50.8 bits (116), Expect = 4e-05
Identities = 23/75 (30%), Positives = 40/75 (53%), Gaps = 1/75 (1%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETD-GXXXXXYRIPIHADF 200
++++ F CP L KPK+F IQAC+G++ D G+ + D R+P +D+
Sbjct: 231 EDIFEMFNNKNCPALQEKPKIFIIQACRGERRDSGVETDDEPMDLDDGSEKKRLPTFSDY 290
Query: 201 LIVFSTVPGYYSWRN 245
IV+ T + + R+
Sbjct: 291 FIVYPTQADHVALRD 305
>UniRef50_A3QVU6 Cluster: Initiator caspase; n=3; Culicidae|Rep:
Initiator caspase - Aedes aegypti (Yellowfever mosquito)
Length = 493
Score = 50.8 bits (116), Expect = 4e-05
Identities = 26/61 (42%), Positives = 36/61 (59%), Gaps = 1/61 (1%)
Frame = +3
Query: 66 LAGKPKLFFIQACQGDKLDGGITLS-NTETDGXXXXXYRIPIHADFLIVFSTVPGYYSWR 242
L GKPKL F+QACQG L + ++ E DG ++ DFL+ +STVPG+ S R
Sbjct: 366 LTGKPKLLFVQACQGSGLQTAVDVAPRLEHDGPSSET-TASVYVDFLVAWSTVPGFASIR 424
Query: 243 N 245
+
Sbjct: 425 H 425
>UniRef50_UPI000065FEF6 Cluster: Homolog of Ictalurus punctatus
"Caspase 8.; n=1; Takifugu rubripes|Rep: Homolog of
Ictalurus punctatus "Caspase 8. - Takifugu rubripes
Length = 340
Score = 50.4 bits (115), Expect = 5e-05
Identities = 27/68 (39%), Positives = 36/68 (52%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTV 221
F A + L KPK+F IQACQG G+ L + +TD IP AD L+ +TV
Sbjct: 211 FKATRQSALVSKPKMFLIQACQGKGTHRGVLLKDLQTD--DCHTLSIPEEADILVATATV 268
Query: 222 PGYYSWRN 245
Y S+R+
Sbjct: 269 EDYVSFRH 276
>UniRef50_Q28GK9 Cluster: Novel protein; n=1; Xenopus
tropicalis|Rep: Novel protein - Xenopus tropicalis
(Western clawed frog) (Silurana tropicalis)
Length = 239
Score = 50.0 bits (114), Expect = 7e-05
Identities = 29/107 (27%), Positives = 55/107 (51%), Gaps = 4/107 (3%)
Frame = +3
Query: 27 NLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITL-SNTETDGXXXXXYRIPIHADFL 203
+L+ + P LAG PKLFF+QAC+G++ D G+ L ++ +T + + D +
Sbjct: 99 DLYDILAPNNSPLLAGVPKLFFVQACRGEQFDEGVFLETDGDTCATDAFSLSLNLPRDSV 158
Query: 204 IVFSTVPGYYSWRNTTRAL---GLCNLFVKN*ETMVLKEIFLHS*HL 335
++F++ G+ +++N ++ LCNL + L I H+
Sbjct: 159 LMFASSEGHVAFQNPGGSVFLQTLCNLLEGEERNLELNRILTRLAHM 205
>UniRef50_Q0PKX0 Cluster: Caspase Xa; n=4; Danio rerio|Rep: Caspase
Xa - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 345
Score = 49.2 bits (112), Expect = 1e-04
Identities = 34/91 (37%), Positives = 40/91 (43%), Gaps = 7/91 (7%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQG-------DKLDGGITLSNTETDGXXXXXYRIPIHADF 200
FT C L GKPKLFFIQAC+G + G S E DG IP DF
Sbjct: 208 FTGINCQKLVGKPKLFFIQACRGLRKQLCVNAQADGDGESEMEVDG-DDFEITIPSDTDF 266
Query: 201 LIVFSTVPGYYSWRNTTRALGLCNLFVKN*E 293
LI ST G+ S+R + +N E
Sbjct: 267 LIARSTTDGHLSYREPDKGSWFIQSLCRNLE 297
>UniRef50_P55211 Cluster: Caspase-9 precursor (EC 3.4.22.62)
(CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6)
(Apoptotic protease Mch-6) (Apoptotic protease-
activating factor 3) (APAF-3) [Contains: Caspase-9
subunit p35; Caspase-9 subunit p10]; n=23;
Tetrapoda|Rep: Caspase-9 precursor (EC 3.4.22.62)
(CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6)
(Apoptotic protease Mch-6) (Apoptotic protease-
activating factor 3) (APAF-3) [Contains: Caspase-9
subunit p35; Caspase-9 subunit p10] - Homo sapiens
(Human)
Length = 416
Score = 49.2 bits (112), Expect = 1e-04
Identities = 31/90 (34%), Positives = 41/90 (45%), Gaps = 22/90 (24%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITL-----------SNTETDG---------- 158
F CP+L GKPKLFFIQAC G++ D G + SN E D
Sbjct: 267 FNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTF 326
Query: 159 -XXXXXYRIPIHADFLIVFSTVPGYYSWRN 245
+P +D + +ST PG+ SWR+
Sbjct: 327 DQLDAISSLPTPSDIFVSYSTFPGFVSWRD 356
>UniRef50_UPI0000E82482 Cluster: PREDICTED: hypothetical protein;
n=2; Gallus gallus|Rep: PREDICTED: hypothetical protein
- Gallus gallus
Length = 266
Score = 48.4 bits (110), Expect = 2e-04
Identities = 25/81 (30%), Positives = 46/81 (56%), Gaps = 2/81 (2%)
Frame = +3
Query: 30 LWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIH--ADFL 203
+++ +A CP LA +PK+FFIQAC+G LD G+ + T++ + +H +
Sbjct: 103 IFHIVSAQNCPALAERPKVFFIQACRGAALDQGVFV-ETDSGQPEPASFSEYLHIPPNTA 161
Query: 204 IVFSTVPGYYSWRNTTRALGL 266
++F+ PGY ++ N ++ L
Sbjct: 162 VMFACSPGYGAFLNPAGSMFL 182
>UniRef50_UPI0000F2DFE8 Cluster: PREDICTED: similar to initiator
caspase; n=1; Monodelphis domestica|Rep: PREDICTED:
similar to initiator caspase - Monodelphis domestica
Length = 473
Score = 48.0 bits (109), Expect = 3e-04
Identities = 24/41 (58%), Positives = 27/41 (65%), Gaps = 3/41 (7%)
Frame = +3
Query: 9 THYKP---DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLD 122
T +KP L YFTA++C TL KPKLFFIQACQ K D
Sbjct: 299 TDWKPVAIKKLLSYFTANECKTLKDKPKLFFIQACQNGKSD 339
>UniRef50_Q56VC9 Cluster: Caspase-8; n=3; Euteleostei|Rep: Caspase-8
- Oryzias latipes (Medaka fish) (Japanese ricefish)
Length = 481
Score = 48.0 bits (109), Expect = 3e-04
Identities = 29/75 (38%), Positives = 37/75 (49%), Gaps = 7/75 (9%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITL-------SNTETDGXXXXXYRIPIHADF 200
F + + P+L GKPKLFFIQACQG G + E D +P ADF
Sbjct: 341 FPSYRAPSLIGKPKLFFIQACQGTLAQSGYLPGSEVKGDAELEADASSSTSNSVPNDADF 400
Query: 201 LIVFSTVPGYYSWRN 245
L+ +TV S+RN
Sbjct: 401 LLGMATVAECKSFRN 415
>UniRef50_Q4V923 Cluster: Zgc:101776 protein; n=8;
Clupeocephala|Rep: Zgc:101776 protein - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 436
Score = 47.2 bits (107), Expect = 5e-04
Identities = 33/96 (34%), Positives = 42/96 (43%), Gaps = 26/96 (27%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETD----GXXXXXYRIPIHA---- 194
Y CP+L GKPKLFFIQAC G + D G +S + G IP+ +
Sbjct: 277 YLNGQNCPSLQGKPKLFFIQACGGGEKDIGFEVSPDDVQPCIGGIDDEMDAIPMSSSSDS 336
Query: 195 ------------------DFLIVFSTVPGYYSWRNT 248
D L+ +ST PGY SWR+T
Sbjct: 337 LSTASDELDARASLPTPSDILVSYSTFPGYVSWRDT 372
>UniRef50_UPI0000F1EFFE Cluster: PREDICTED: hypothetical protein;
n=4; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 277
Score = 46.8 bits (106), Expect = 6e-04
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 4/72 (5%)
Frame = +3
Query: 27 NLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITL----SNTETDGXXXXXYRIPIHA 194
NL ++ + P + K KLF IQAC+G LDGG+ L S++E IPI
Sbjct: 121 NLAEIYSCFRSPIMKDKSKLFLIQACRGGDLDGGVELETDSSSSEEQDILSELLSIPI-- 178
Query: 195 DFLIVFSTVPGY 230
D + ++T PGY
Sbjct: 179 DTAVTYATSPGY 190
>UniRef50_P42575 Cluster: Caspase-2 precursor (EC 3.4.22.55)
(CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural
precursor cell expressed developmentally down- regulated
protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18;
Caspase-2 subunit p13; Caspase-2 subunit p12]; n=34;
Euteleostomi|Rep: Caspase-2 precursor (EC 3.4.22.55)
(CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural
precursor cell expressed developmentally down- regulated
protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18;
Caspase-2 subunit p13; Caspase-2 subunit p12] - Homo
sapiens (Human)
Length = 452
Score = 46.0 bits (104), Expect = 0.001
Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 12/83 (14%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSN----------TETDG--XXXXXYRIP 185
F CP+L KPK+FFIQAC+GD+ D G+ + E+D R+P
Sbjct: 300 FDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLP 359
Query: 186 IHADFLIVFSTVPGYYSWRNTTR 254
+D + ++ + G + RNT R
Sbjct: 360 TRSDMICGYACLKGTAAMRNTKR 382
>UniRef50_UPI0000E4A098 Cluster: PREDICTED: similar to CGI-141
protein; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to CGI-141 protein -
Strongylocentrotus purpuratus
Length = 225
Score = 45.6 bits (103), Expect = 0.001
Identities = 17/24 (70%), Positives = 22/24 (91%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGD 113
F++D CPTL GKPKLFF+QAC+G+
Sbjct: 74 FSSDLCPTLNGKPKLFFLQACRGE 97
>UniRef50_Q9Y1U6 Cluster: Cell death protein CED-3; n=1;
Pristionchus pacificus|Rep: Cell death protein CED-3 -
Pristionchus pacificus
Length = 417
Score = 45.6 bits (103), Expect = 0.001
Identities = 26/92 (28%), Positives = 42/92 (45%), Gaps = 11/92 (11%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETD-----------GXXXXXYRIPI 188
F P LAGKPK+ +QAC+G++ D G +++ G + P
Sbjct: 271 FNTHNAPHLAGKPKIILLQACRGERKDIGYEETDSGRPFAFLECLGMGGGGMMTRNKRPA 330
Query: 189 HADFLIVFSTVPGYYSWRNTTRALGLCNLFVK 284
+D L+ ++T Y SWRN+ + FV+
Sbjct: 331 ESDILVAYATPAHYVSWRNSEKGSWFIQSFVE 362
>UniRef50_UPI0000F1EBE3 Cluster: PREDICTED: similar to caspase 10;
n=2; Danio rerio|Rep: PREDICTED: similar to caspase 10 -
Danio rerio
Length = 306
Score = 45.2 bits (102), Expect = 0.002
Identities = 27/73 (36%), Positives = 39/73 (53%), Gaps = 6/73 (8%)
Frame = +3
Query: 54 KCPTLAGKPKLFFIQACQGDKLDGGI---TLSNTE---TDGXXXXXYRIPIHADFLIVFS 215
+C +L KPKLFFIQAC+G + + T + E IP AD+L+ S
Sbjct: 169 RCSSLYQKPKLFFIQACRGTQNQRAVFPQTFTEDEDVLASDAGVPRDSIPEMADYLMAMS 228
Query: 216 TVPGYYSWRNTTR 254
TVP Y S+R+ ++
Sbjct: 229 TVPWYASYRDKSK 241
>UniRef50_Q9GV89 Cluster: Caspase 3A; n=1; Hydra vulgaris|Rep:
Caspase 3A - Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 347
Score = 45.2 bits (102), Expect = 0.002
Identities = 30/101 (29%), Positives = 45/101 (44%)
Frame = +3
Query: 18 KPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHAD 197
K ++L F AD P KPK+F +QAC+G+K D + IP+ +D
Sbjct: 183 KINSLLENFKADNAPAFDKKPKVFIVQACRGEK-DDIRKDGIKDAKRTYYNESTIPMLSD 241
Query: 198 FLIVFSTVPGYYSWRNTTRALGLCNLFVKN*ETMVLKEIFL 320
F++ + GY + R+T + VK KE FL
Sbjct: 242 FVVAYPCAAGYTALRSTVKGSWFIQELVKCLSIFYDKEDFL 282
>UniRef50_UPI00006A1E20 Cluster: Caspase-9 precursor (EC 3.4.22.62)
(CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6)
(Apoptotic protease Mch-6) (Apoptotic protease-
activating factor 3) (APAF-3) [Contains: Caspase-9
subunit p35; Caspase-9 subunit p10].; n=1; Xenopus
tropicalis|Rep: Caspase-9 precursor (EC 3.4.22.62)
(CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6)
(Apoptotic protease Mch-6) (Apoptotic protease-
activating factor 3) (APAF-3) [Contains: Caspase-9
subunit p35; Caspase-9 subunit p10]. - Xenopus
tropicalis
Length = 141
Score = 44.8 bits (101), Expect = 0.002
Identities = 17/24 (70%), Positives = 19/24 (79%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQG 110
YF KCP+L GKPK+FFIQAC G
Sbjct: 51 YFNGSKCPSLRGKPKIFFIQACGG 74
>UniRef50_Q4SNC6 Cluster: Chromosome 8 SCAF14543, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 8
SCAF14543, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 397
Score = 44.8 bits (101), Expect = 0.002
Identities = 18/35 (51%), Positives = 24/35 (68%), Gaps = 2/35 (5%)
Frame = +3
Query: 33 WYYFTADK--CPTLAGKPKLFFIQACQGDKLDGGI 131
W + D CP L KPK+FFIQAC+GD++D G+
Sbjct: 265 WVFTAFDNAHCPLLQNKPKMFFIQACRGDEMDCGV 299
>UniRef50_Q69HP8 Cluster: Caspase-1-like; n=1; Ciona
intestinalis|Rep: Caspase-1-like - Ciona intestinalis
(Transparent sea squirt)
Length = 254
Score = 44.0 bits (99), Expect = 0.004
Identities = 16/25 (64%), Positives = 23/25 (92%)
Frame = +3
Query: 45 TADKCPTLAGKPKLFFIQACQGDKL 119
+A +CP+LAGKPKLFF+QAC+G ++
Sbjct: 163 SATECPSLAGKPKLFFVQACRGKEI 187
>UniRef50_UPI0000F21D96 Cluster: PREDICTED: hypothetical protein,
partial; n=1; Danio rerio|Rep: PREDICTED: hypothetical
protein, partial - Danio rerio
Length = 170
Score = 43.6 bits (98), Expect = 0.006
Identities = 18/36 (50%), Positives = 23/36 (63%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTE 149
F DKC +L GKPK+F QAC+GDK D + + E
Sbjct: 123 FKGDKCRSLVGKPKIFIWQACRGDKKDDPVAPMSAE 158
>UniRef50_A2I5C3 Cluster: Putative caspase 3; n=1; Mytilus
galloprovincialis|Rep: Putative caspase 3 - Mytilus
galloprovincialis (Mediterranean mussel)
Length = 56
Score = 43.6 bits (98), Expect = 0.006
Identities = 19/42 (45%), Positives = 25/42 (59%)
Frame = +3
Query: 6 ETHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGI 131
+T K + YF A+ C L KPK+F IQAC+G L GG+
Sbjct: 14 DTSIKMKSFLSYFNAENCKELQLKPKIFIIQACRGTGLGGGV 55
>UniRef50_Q4S1R8 Cluster: Chromosome undetermined SCAF14764, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF14764, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 279
Score = 43.2 bits (97), Expect = 0.008
Identities = 23/78 (29%), Positives = 46/78 (58%), Gaps = 5/78 (6%)
Frame = +3
Query: 27 NLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITL---SNTETDGXXXXXYR--IPIH 191
+++ YF +KC + K K+F IQAC+GD LD G+ + ++ + D ++ + +
Sbjct: 107 HIFAYFD-NKC--MEKKTKVFLIQACRGDALDDGVEVDAAADADADASAACVFQQCLSVP 163
Query: 192 ADFLIVFSTVPGYYSWRN 245
D +++++T PGY ++ N
Sbjct: 164 LDTVVMYATAPGYAAFMN 181
>UniRef50_UPI0000F2CF2E Cluster: PREDICTED: similar to caspase 12;
n=1; Monodelphis domestica|Rep: PREDICTED: similar to
caspase 12 - Monodelphis domestica
Length = 405
Score = 41.9 bits (94), Expect = 0.017
Identities = 19/37 (51%), Positives = 25/37 (67%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGIT 134
D ++ F CP+L GKPK+ IQAC+G+KL GIT
Sbjct: 259 DVIFQIFNDSNCPSLKGKPKVIIIQACRGEKL--GIT 293
>UniRef50_UPI0000D56041 Cluster: PREDICTED: similar to CG7486-PB,
isoform B; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG7486-PB, isoform B - Tribolium castaneum
Length = 568
Score = 41.9 bits (94), Expect = 0.017
Identities = 24/64 (37%), Positives = 34/64 (53%), Gaps = 2/64 (3%)
Frame = +3
Query: 60 PTLAGKPKLFFIQACQGDKLDG-GITLSNTETDGXXXXXYR-IPIHADFLIVFSTVPGYY 233
P L+GKPK+ +Q+CQG + + ETDG +P AD ++TVPGY
Sbjct: 437 PHLSGKPKVLILQSCQGTRCQKIQSDDDDIETDGPSSPVQESVPPIADLFTFWATVPGYG 496
Query: 234 SWRN 245
+ RN
Sbjct: 497 AIRN 500
>UniRef50_UPI0000E45DDA Cluster: PREDICTED: similar to caspase 3;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to caspase 3 - Strongylocentrotus purpuratus
Length = 526
Score = 41.5 bits (93), Expect = 0.023
Identities = 29/93 (31%), Positives = 40/93 (43%), Gaps = 22/93 (23%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQG----------------------DKLDGGITLSNTETD 155
F+ +CP L GKPK+FFIQAC+G D D S TD
Sbjct: 323 FSGRQCPALLGKPKIFFIQACRGQMRTKSALDTDDPRRLSPIEMVDDPDIDSCSSRRPTD 382
Query: 156 GXXXXXYRIPIHADFLIVFSTVPGYYSWRNTTR 254
+P +AD + ++T GY+S RN +
Sbjct: 383 DAVDIDGDVPDNADIYVAYATSEGYFSIRNQVK 415
>UniRef50_Q9I9L7 Cluster: Caspase; n=2; Danio rerio|Rep: Caspase -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 383
Score = 41.5 bits (93), Expect = 0.023
Identities = 30/104 (28%), Positives = 50/104 (48%), Gaps = 6/104 (5%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIH--AD 197
DN++ ++ CP L KPK+ IQAC+G + G + S+ E D +H D
Sbjct: 244 DNVYRRLNSENCPALRDKPKVILIQACRGGE-HGRVWASDGEPDEPIEIEDDDFVHKEKD 302
Query: 198 FLIVFSTVPGYYSWRN----TTRALGLCNLFVKN*ETMVLKEIF 317
F+ + S P S+R+ T L ++F+K ++E+F
Sbjct: 303 FISLMSCTPDTKSYRHVQNGTFYVQTLVDVFIKCAHEDHIEELF 346
>UniRef50_P55865 Cluster: Caspase-1-A precursor; n=3; Xenopus|Rep:
Caspase-1-A precursor - Xenopus laevis (African clawed
frog)
Length = 386
Score = 41.5 bits (93), Expect = 0.023
Identities = 22/78 (28%), Positives = 36/78 (46%), Gaps = 1/78 (1%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG-XXXXXYRIPIHADF 200
D ++ F C L KPK+ IQAC+G+ G + + + + + ADF
Sbjct: 248 DEIFSTFNNVNCSKLRNKPKVIIIQACRGENKGGLLVRDDVASPPLEDDGLHFVQREADF 307
Query: 201 LIVFSTVPGYYSWRNTTR 254
+ S+ P SWR+ T+
Sbjct: 308 ICFCSSTPDTVSWRDPTK 325
>UniRef50_Q0Z8U7 Cluster: Caspase-8; n=1; Haemaphysalis
longicornis|Rep: Caspase-8 - Haemaphysalis longicornis
(Bush tick)
Length = 306
Score = 41.1 bits (92), Expect = 0.030
Identities = 16/27 (59%), Positives = 20/27 (74%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLD 122
F CP+L GKPKLFF+QAC+G + D
Sbjct: 156 FNDSNCPSLQGKPKLFFVQACRGREDD 182
>UniRef50_P29466-2 Cluster: Isoform Beta of P29466 ; n=11;
Theria|Rep: Isoform Beta of P29466 - Homo sapiens
(Human)
Length = 383
Score = 40.3 bits (90), Expect = 0.053
Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 11/76 (14%)
Frame = +3
Query: 57 CPTLAGKPKLFFIQACQGDK-----------LDGGITLSNTETDGXXXXXYRIPIHADFL 203
CP+L KPK+ IQAC+GD + G ++L TE + + I DF+
Sbjct: 249 CPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTE-EFEDDAIKKAHIEKDFI 307
Query: 204 IVFSTVPGYYSWRNTT 251
S+ P SWR+ T
Sbjct: 308 AFCSSTPDNVSWRHPT 323
>UniRef50_P29466 Cluster: Caspase-1 precursor (EC 3.4.22.36)
(CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1
beta-converting enzyme) (ICE) (Interleukin- 1
beta-converting enzyme) (p45) [Contains: Caspase-1
subunit p20; Caspase-1 subunit p10]; n=29; Eutheria|Rep:
Caspase-1 precursor (EC 3.4.22.36) (CASP-1)
(Interleukin-1 beta convertase) (IL-1BC) (IL-1
beta-converting enzyme) (ICE) (Interleukin- 1
beta-converting enzyme) (p45) [Contains: Caspase-1
subunit p20; Caspase-1 subunit p10] - Homo sapiens
(Human)
Length = 404
Score = 40.3 bits (90), Expect = 0.053
Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 11/76 (14%)
Frame = +3
Query: 57 CPTLAGKPKLFFIQACQGDK-----------LDGGITLSNTETDGXXXXXYRIPIHADFL 203
CP+L KPK+ IQAC+GD + G ++L TE + + I DF+
Sbjct: 270 CPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTE-EFEDDAIKKAHIEKDFI 328
Query: 204 IVFSTVPGYYSWRNTT 251
S+ P SWR+ T
Sbjct: 329 AFCSSTPDNVSWRHPT 344
>UniRef50_Q7ZXD2 Cluster: MGC53258 protein; n=3; Xenopus|Rep:
MGC53258 protein - Xenopus laevis (African clawed frog)
Length = 419
Score = 39.9 bits (89), Expect = 0.070
Identities = 14/25 (56%), Positives = 19/25 (76%)
Frame = +3
Query: 57 CPTLAGKPKLFFIQACQGDKLDGGI 131
CP L KPK+FF QAC+G++ D G+
Sbjct: 273 CPQLQNKPKMFFFQACRGEETDRGV 297
>UniRef50_Q504J1 Cluster: Caspase b; n=7; Danio rerio|Rep: Caspase b
- Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 404
Score = 39.9 bits (89), Expect = 0.070
Identities = 21/77 (27%), Positives = 36/77 (46%)
Frame = +3
Query: 15 YKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHA 194
Y + + + + CP L KPK+ IQAC+G + G + D + +
Sbjct: 267 YFIEETFSHLNSVNCPALIDKPKVILIQACRGGQSSGVLA-----QDSVFASDSWVHMEK 321
Query: 195 DFLIVFSTVPGYYSWRN 245
DF+ ST+P +++RN
Sbjct: 322 DFVCFMSTMPNTFAYRN 338
>UniRef50_UPI0000E47913 Cluster: PREDICTED: similar to cysteine
protease CPP32 isoform alpha; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to cysteine protease
CPP32 isoform alpha - Strongylocentrotus purpuratus
Length = 505
Score = 39.5 bits (88), Expect = 0.093
Identities = 24/76 (31%), Positives = 39/76 (51%), Gaps = 8/76 (10%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKLDGGITLS-------NTET-DGXXXXXYRIPIHAD 197
F D+ P + KPK+F IQ+C+G + G++ S N ET D P+++D
Sbjct: 364 FHGDQIPKMQDKPKVFIIQSCRGKEKQRGVSSSDGPATELNPETMDYPEPAVTTRPVNSD 423
Query: 198 FLIVFSTVPGYYSWRN 245
LI ++T ++RN
Sbjct: 424 ILIAYATSQSKKAFRN 439
>UniRef50_UPI000155BC01 Cluster: PREDICTED: similar to cellular
FLICE-like inhibitory protein long form; n=1;
Ornithorhynchus anatinus|Rep: PREDICTED: similar to
cellular FLICE-like inhibitory protein long form -
Ornithorhynchus anatinus
Length = 508
Score = 39.1 bits (87), Expect = 0.12
Identities = 15/21 (71%), Positives = 17/21 (80%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQA 101
+FT D CP L GKPKLFFIQ+
Sbjct: 369 FFTGDACPALLGKPKLFFIQS 389
>UniRef50_Q07BT4 Cluster: Caspase-1; n=2; Percomorpha|Rep: Caspase-1
- Dicentrarchus labrax (European sea bass)
Length = 394
Score = 39.1 bits (87), Expect = 0.12
Identities = 15/41 (36%), Positives = 28/41 (68%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNT 146
+N++ + ++KCP L KPK+ IQAC+G+ G + +S++
Sbjct: 240 NNIYEHLGSEKCPALLNKPKIIIIQACRGN-AGGAVLVSDS 279
>UniRef50_UPI0000E47F37 Cluster: PREDICTED: similar to caspase-3,
partial; n=3; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to caspase-3, partial -
Strongylocentrotus purpuratus
Length = 608
Score = 38.7 bits (86), Expect = 0.16
Identities = 13/26 (50%), Positives = 19/26 (73%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQACQGDKL 119
F+ + CP L GKPK+ QAC+G+K+
Sbjct: 105 FSGNNCPALIGKPKIMIFQACRGEKI 130
>UniRef50_Q178B7 Cluster: Caspase-3; n=2; Aedes aegypti|Rep:
Caspase-3 - Aedes aegypti (Yellowfever mosquito)
Length = 391
Score = 38.7 bits (86), Expect = 0.16
Identities = 31/84 (36%), Positives = 36/84 (42%)
Frame = +3
Query: 63 TLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTVPGYYSWR 242
TL GKPKLFF+QAC+GD + E D + D L FST G S+R
Sbjct: 283 TLKGKPKLFFVQACKGDAV--------MEADATRTATNKF----DILKCFSTYEGTLSFR 330
Query: 243 NTTRALGLCNLFVKN*ETMVLKEI 314
TT K E KEI
Sbjct: 331 YTTEGTTFIQTLFKLIEQNSDKEI 354
>UniRef50_Q9XYF4 Cluster: Caspase Nc precursor (EC 3.4.22.-)
(NEDD2-like caspase DRONC) [Contains: Caspase Nc subunit
1; Caspase Nc subunit 2]; n=2; Sophophora|Rep: Caspase
Nc precursor (EC 3.4.22.-) (NEDD2-like caspase DRONC)
[Contains: Caspase Nc subunit 1; Caspase Nc subunit 2] -
Drosophila melanogaster (Fruit fly)
Length = 450
Score = 38.7 bits (86), Expect = 0.16
Identities = 24/86 (27%), Positives = 38/86 (44%), Gaps = 17/86 (19%)
Frame = +3
Query: 39 YFTADKCPTLAGKPKLFFIQACQGDKLDGGITLS-----------------NTETDGXXX 167
+F KCP L KPK+ C+GD+ D G + +T+T+G
Sbjct: 297 HFQTAKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPS 356
Query: 168 XXYRIPIHADFLIVFSTVPGYYSWRN 245
+P AD L+ ++ PGY + R+
Sbjct: 357 PSTNVPSLADTLVCYANTPGYVTHRD 382
>UniRef50_Q0Z855 Cluster: Caspase-2; n=1; Haemaphysalis
longicornis|Rep: Caspase-2 - Haemaphysalis longicornis
(Bush tick)
Length = 340
Score = 37.9 bits (84), Expect = 0.28
Identities = 16/35 (45%), Positives = 21/35 (60%)
Frame = +3
Query: 27 NLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGI 131
+++ F + CP L GKPKLFFI +G D GI
Sbjct: 120 DVYQLFDNENCPNLRGKPKLFFIPGSRGCMWDNGI 154
>UniRef50_A6NFM5 Cluster: Uncharacterized protein ENSP00000371619;
n=11; Eutheria|Rep: Uncharacterized protein
ENSP00000371619 - Homo sapiens (Human)
Length = 408
Score = 37.9 bits (84), Expect = 0.28
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 1/59 (1%)
Frame = +3
Query: 54 KCPTLAGKPKLFFIQACQGDKLDGGITLSNTETD-GXXXXXYRIPIHADFLIVFSTVPG 227
+C L G+PK+F +QAC+G D G+ + +P HAD L +++ G
Sbjct: 254 RCQVLQGRPKIFLLQACRGGNRDAGVGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQG 312
>UniRef50_P42573 Cluster: Cell death protein 3 precursor (EC
3.4.22.-) [Contains: Cell death protein 3 subunit 1;
Cell death protein 3 subunit 2]; n=3;
Caenorhabditis|Rep: Cell death protein 3 precursor (EC
3.4.22.-) [Contains: Cell death protein 3 subunit 1;
Cell death protein 3 subunit 2] - Caenorhabditis elegans
Length = 503
Score = 37.5 bits (83), Expect = 0.37
Identities = 16/37 (43%), Positives = 24/37 (64%)
Frame = +3
Query: 48 ADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG 158
A P LA KPK+ F+QAC+G++ D G + ++ DG
Sbjct: 340 AANAPRLANKPKIVFVQACRGERRDNGFPVLDS-VDG 375
Score = 35.9 bits (79), Expect = 1.1
Identities = 14/38 (36%), Positives = 25/38 (65%)
Frame = +2
Query: 257 SWFMQSLCEELRNYGTQRDILTLLTFVCQRVALDFESN 370
SWF+Q++CE + D++ LLT V ++VA F+++
Sbjct: 435 SWFIQAVCEVFSTHAKDMDVVELLTEVNKKVACGFQTS 472
>UniRef50_UPI0000661247 Cluster: Homolog of Brachydanio rerio
"Caspase.; n=4; Takifugu rubripes|Rep: Homolog of
Brachydanio rerio "Caspase. - Takifugu rubripes
Length = 358
Score = 37.1 bits (82), Expect = 0.50
Identities = 13/31 (41%), Positives = 20/31 (64%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDK 116
D ++ + + CP L KPK+ IQAC+GD+
Sbjct: 213 DKIYRHLGPEHCPALLNKPKIIIIQACRGDE 243
>UniRef50_A3QU14 Cluster: DNA polymerase; n=1; Oryctes rhinoceros
virus|Rep: DNA polymerase - Oryctes rhinoceros virus
Length = 1280
Score = 37.1 bits (82), Expect = 0.50
Identities = 21/79 (26%), Positives = 37/79 (46%)
Frame = -3
Query: 502 WYSILMRRFRKFIKLFFSKQEKACQHTIYARYLFLLMHRCDIWCI*LKI*SNSLTNKCQE 323
+Y + IK K + T+ ++Y+ LLM + + ++++T K
Sbjct: 1193 YYQNMYTTIFNLIKFHIKKNNEPYNITLSSKYILLLMLKGFLDAYEATFLTHAVTCKSDV 1252
Query: 322 CKNISLSTIVSQFFTKRLH 266
C NISLS+ Q FT+ +H
Sbjct: 1253 CNNISLSSDADQIFTEPIH 1271
>UniRef50_UPI0000F2CF2D Cluster: PREDICTED: similar to
evolutionarily related interleukin-1beta converting
enzyme; n=1; Monodelphis domestica|Rep: PREDICTED:
similar to evolutionarily related interleukin-1beta
converting enzyme - Monodelphis domestica
Length = 372
Score = 36.7 bits (81), Expect = 0.65
Identities = 22/83 (26%), Positives = 33/83 (39%), Gaps = 9/83 (10%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSNTETDG---------XXXXXY 176
D ++ CP L KPK+ IQAC+G K + + E +
Sbjct: 228 DTIFNILNTKNCPKLKDKPKVIIIQACRGVKSGKVLMRDSPEISEDSEINPELLEEDAIF 287
Query: 177 RIPIHADFLIVFSTVPGYYSWRN 245
+ DF+ FS+ P SWR+
Sbjct: 288 ETHVEKDFISFFSSTPNNVSWRD 310
>UniRef50_UPI000065DDFC Cluster: CASP8 and FADD-like apoptosis
regulator precursor (Cellular FLICE-like inhibitory
protein) (c-FLIP) (Caspase-eight-related protein)
(Casper) (Caspase-like apoptosis regulatory protein)
(CLARP) (MACH-related inducer of toxicity) (MRIT)
(Caspase homolog) (C; n=1; Takifugu rubripes|Rep: CASP8
and FADD-like apoptosis regulator precursor (Cellular
FLICE-like inhibitory protein) (c-FLIP)
(Caspase-eight-related protein) (Casper) (Caspase-like
apoptosis regulatory protein) (CLARP) (MACH-related
inducer of toxicity) (MRIT) (Caspase homolog) (C -
Takifugu rubripes
Length = 472
Score = 36.7 bits (81), Expect = 0.65
Identities = 16/25 (64%), Positives = 18/25 (72%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQ 98
D++ FTA CP LAGKPKL FIQ
Sbjct: 332 DSVSQQFTAKGCPALAGKPKLLFIQ 356
>UniRef50_Q498I3 Cluster: LOC780745 protein; n=6; Xenopus|Rep:
LOC780745 protein - Xenopus laevis (African clawed frog)
Length = 512
Score = 36.7 bits (81), Expect = 0.65
Identities = 14/25 (56%), Positives = 17/25 (68%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQ 98
D + + FT CP L GKPKLFF+Q
Sbjct: 377 DRIKHIFTGKSCPDLLGKPKLFFVQ 401
>UniRef50_P51878 Cluster: Caspase-5 precursor (EC 3.4.22.58)
(CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III)
[Contains: Caspase-5 subunit p20; Caspase-5 subunit
p10]; n=25; Eutheria|Rep: Caspase-5 precursor (EC
3.4.22.58) (CASP-5) (ICH-3 protease) (TY protease)
(ICE(rel)-III) [Contains: Caspase-5 subunit p20;
Caspase-5 subunit p10] - Homo sapiens (Human)
Length = 418
Score = 36.3 bits (80), Expect = 0.86
Identities = 25/87 (28%), Positives = 39/87 (44%), Gaps = 10/87 (11%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDK------LDGGITL----SNTETDGXXXXX 173
D ++ F C +L KPK+ +QAC+G+K D +L S + +
Sbjct: 273 DTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLAVISSQSSENLEADSV 332
Query: 174 YRIPIHADFLIVFSTVPGYYSWRNTTR 254
+I DF+ S+ P SWR+ TR
Sbjct: 333 CKIHEEKDFIAFCSSTPHNVSWRDRTR 359
>UniRef50_O15519-8 Cluster: Isoform 8 of O15519 ; n=3;
Homo/Pan/Gorilla group|Rep: Isoform 8 of O15519 - Homo
sapiens (Human)
Length = 445
Score = 35.9 bits (79), Expect = 1.1
Identities = 14/19 (73%), Positives = 15/19 (78%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQ 98
F D CP LAGKPK+FFIQ
Sbjct: 305 FMGDSCPYLAGKPKMFFIQ 323
>UniRef50_O15519 Cluster: CASP8 and FADD-like apoptosis regulator
precursor (Cellular FLICE-like inhibitory protein)
(c-FLIP) (Caspase-eight-related protein) (Casper)
(Caspase-like apoptosis regulatory protein) (CLARP)
(MACH-related inducer of toxicity) (MRIT) (Caspase
homolog) (CASH) (Inhibitor of FLICE) (I-FLICE)
(FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin)
[Contains: CASP8 and FADD-like apoptosis regulator
subunit p43; CASP8 and FADD-like apoptosis regulator
subunit p12]; n=46; Amniota|Rep: CASP8 and FADD-like
apoptosis regulator precursor (Cellular FLICE-like
inhibitory protein) (c-FLIP) (Caspase-eight-related
protein) (Casper) (Caspase-like apoptosis regulatory
protein) (CLARP) (MACH-related inducer of toxicity)
(MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE)
(I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1)
(Usurpin) [Contains: CASP8 and FADD-like apoptosis
regulator subunit p43; CASP8 and FADD-like apoptosis
regulator subunit p12] - Homo sapiens (Human)
Length = 480
Score = 35.9 bits (79), Expect = 1.1
Identities = 14/19 (73%), Positives = 15/19 (78%)
Frame = +3
Query: 42 FTADKCPTLAGKPKLFFIQ 98
F D CP LAGKPK+FFIQ
Sbjct: 340 FMGDSCPYLAGKPKMFFIQ 358
>UniRef50_UPI000051A33A Cluster: PREDICTED: similar to CG6597-PA,
isoform A; n=2; Coelomata|Rep: PREDICTED: similar to
CG6597-PA, isoform A - Apis mellifera
Length = 478
Score = 35.5 bits (78), Expect = 1.5
Identities = 14/28 (50%), Positives = 16/28 (57%)
Frame = +3
Query: 15 YKPDNLWYYFTADKCPTLAGKPKLFFIQ 98
Y LW F D CP L KPK+FF+Q
Sbjct: 166 YPAQMLWMPFLPDSCPGLIDKPKIFFLQ 193
>UniRef50_O42284 Cluster: Caspase-1; n=3; Gallus gallus|Rep:
Caspase-1 - Gallus gallus (Chicken)
Length = 283
Score = 35.1 bits (77), Expect = 2.0
Identities = 23/90 (25%), Positives = 41/90 (45%), Gaps = 14/90 (15%)
Frame = +3
Query: 24 DNLWYYFTADKCPTLAGKPKLFFIQACQGDKLDGGITLSN--------TETDGXXXXXYR 179
+ ++ F C L GKPK+ IQ C+GD + G + + + + +DG +
Sbjct: 137 NTIYENFNNKHCRALMGKPKVVIIQCCRGDNI-GSVQIRDSIDPEMPTSTSDGWRCVELQ 195
Query: 180 ------IPIHADFLIVFSTVPGYYSWRNTT 251
+ +DF ++S+ P SWR+ T
Sbjct: 196 GSKTREAHLESDFATLYSSTPDTVSWRSPT 225
>UniRef50_Q7KHK9 Cluster: DREAM; n=2; Sophophora|Rep: DREAM -
Drosophila melanogaster (Fruit fly)
Length = 527
Score = 34.3 bits (75), Expect = 3.5
Identities = 15/32 (46%), Positives = 19/32 (59%)
Frame = +3
Query: 63 TLAGKPKLFFIQACQGDKLDGGITLSNTETDG 158
TL KPKL F+QAC+GD GG + +G
Sbjct: 416 TLKDKPKLIFVQACKGDCQLGGFMTDAAQPNG 447
>UniRef50_P29466-4 Cluster: Isoform Delta of P29466 ; n=2;
Euarchontoglires|Rep: Isoform Delta of P29466 - Homo
sapiens (Human)
Length = 263
Score = 33.5 bits (73), Expect = 6.1
Identities = 12/21 (57%), Positives = 16/21 (76%)
Frame = +3
Query: 57 CPTLAGKPKLFFIQACQGDKL 119
CP+L KPK+ IQAC+GD +
Sbjct: 177 CPSLKDKPKVIIIQACRGDNV 197
>UniRef50_Q74BT1 Cluster: Fibronectin type III domain protein; n=2;
Geobacter|Rep: Fibronectin type III domain protein -
Geobacter sulfurreducens
Length = 1047
Score = 33.5 bits (73), Expect = 6.1
Identities = 19/75 (25%), Positives = 28/75 (37%)
Frame = +3
Query: 60 PTLAGKPKLFFIQACQGDKLDGGITLSNTETDGXXXXXYRIPIHADFLIVFSTVPGYYSW 239
P+ P + G + G +T+S T +D ++ +T P YSW
Sbjct: 689 PSDTAAPTVAVSAPANGATVSGTVTVSATASDNVGVTKVEFMVNGTVASTVTTAPYSYSW 748
Query: 240 RNTTRALGLCNLFVK 284
TT A G L K
Sbjct: 749 NTTTSANGTYTLTAK 763
>UniRef50_Q9NBW3 Cluster: Cysteine protease; n=4; melanogaster
subgroup|Rep: Cysteine protease - Drosophila
melanogaster (Fruit fly)
Length = 255
Score = 33.1 bits (72), Expect = 8.1
Identities = 16/35 (45%), Positives = 22/35 (62%)
Frame = +3
Query: 6 ETHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQG 110
E H D L+ F + PTL+GKPK+ +QAC+G
Sbjct: 127 EYHLDDDVLFPLF---RNPTLSGKPKILIVQACKG 158
>UniRef50_Q8I5D6 Cluster: Putative uncharacterized protein; n=3;
Plasmodium|Rep: Putative uncharacterized protein -
Plasmodium falciparum (isolate 3D7)
Length = 818
Score = 33.1 bits (72), Expect = 8.1
Identities = 16/36 (44%), Positives = 19/36 (52%)
Frame = -3
Query: 781 NNYNL*DLKKPTFIYL*NIHIYCQ*KKYHLSFFHHN 674
NNY+ + KK T Y N H Y Y+ SF HHN
Sbjct: 229 NNYSFINKKKYTQYYNNNTHSYFHIYNYYSSFIHHN 264
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 718,615,777
Number of Sequences: 1657284
Number of extensions: 14127260
Number of successful extensions: 30109
Number of sequences better than 10.0: 121
Number of HSP's better than 10.0 without gapping: 28753
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 30030
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 66262109095
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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