Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= tesV0561.Seq
(823 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P26267 Cluster: Pyruvate dehydrogenase E1 component sub... 127 3e-28
UniRef50_Q9W4H4 Cluster: CG7024-PA; n=2; Sophophora|Rep: CG7024-... 120 4e-26
UniRef50_UPI0000E4A5CB Cluster: PREDICTED: hypothetical protein,... 113 7e-24
UniRef50_Q6NX32 Cluster: Pyruvate dehydrogenase (Lipoamide) alph... 105 1e-21
UniRef50_Q4T3C0 Cluster: Chromosome undetermined SCAF10102, whol... 103 5e-21
UniRef50_P08559 Cluster: Pyruvate dehydrogenase E1 component sub... 101 2e-20
UniRef50_Q23KL2 Cluster: Pyruvate dehydrogenase E1 component; n=... 91 2e-17
UniRef50_Q1EGI2 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 87 5e-16
UniRef50_Q9R9N5 Cluster: Pyruvate dehydrogenase E1 component sub... 86 9e-16
UniRef50_Q8H1Y0 Cluster: Pyruvate dehydrogenase E1 component sub... 86 9e-16
UniRef50_A2QWB4 Cluster: Catalytic activity: Pyruvate + Lipoamid... 85 2e-15
UniRef50_P16387 Cluster: Pyruvate dehydrogenase E1 component sub... 85 3e-15
UniRef50_Q1EGH8 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 82 1e-14
UniRef50_O66112 Cluster: Pyruvate dehydrogenase E1 component sub... 76 1e-12
UniRef50_O96865 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 73 7e-12
UniRef50_Q4WHM5 Cluster: Pyruvate dehydrogenase E1 component alp... 70 6e-11
UniRef50_A6DTS3 Cluster: Dehydrogenase complex, E1 component, al... 70 8e-11
UniRef50_Q5FNM5 Cluster: Pyruvate dehydrogenase E1 component alp... 69 1e-10
UniRef50_Q4QDQ1 Cluster: Pyruvate dehydrogenase E1 component alp... 69 1e-10
UniRef50_Q74AD3 Cluster: Dehydrogenase complex, E1 component, al... 67 6e-10
UniRef50_Q2S150 Cluster: Pyruvate dehydrogenase E1 component, al... 66 8e-10
UniRef50_A7CXZ4 Cluster: Pyruvate dehydrogenase; n=1; Opitutacea... 66 8e-10
UniRef50_Q9Z8N4 Cluster: Pyruvate Dehydrogenase Alpha; n=8; Chla... 66 1e-09
UniRef50_Q8SQM8 Cluster: PYRUVATE DEHYDROGENASE E1 COMPONENT ALP... 66 1e-09
UniRef50_A6GG24 Cluster: Pyruvate dehydrogenase (Lipoamide), alp... 64 3e-09
UniRef50_Q1ATM5 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacte... 62 2e-08
UniRef50_Q95VS6 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 62 2e-08
UniRef50_Q12FH4 Cluster: Pyruvate dehydrogenase; n=37; Bacteria|... 60 9e-08
UniRef50_A3VIE7 Cluster: Tpp-dependent acetoin dehydrogenase e1 ... 60 9e-08
UniRef50_A5UU15 Cluster: Pyruvate dehydrogenase; n=3; Chloroflex... 59 2e-07
UniRef50_Q2ITF8 Cluster: Acetoin dehydrogenase (TPP-dependent) a... 56 1e-06
UniRef50_Q5VGY4 Cluster: Pyruvate dehydrogenase alpha subunit; n... 56 1e-06
UniRef50_A0LSF3 Cluster: Pyruvate dehydrogenase; n=5; Bacteria|R... 55 2e-06
UniRef50_A5V540 Cluster: Dehydrogenase, E1 component; n=3; Prote... 55 2e-06
UniRef50_Q6MAE2 Cluster: Putative pyruvate dehydrogenase (Lipoam... 53 8e-06
UniRef50_Q2WB98 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 53 1e-05
UniRef50_A0LTQ9 Cluster: Pyruvate dehydrogenase; n=1; Acidotherm... 52 1e-05
UniRef50_A7BPK6 Cluster: Pyruvate dehydrogenase; n=1; Beggiatoa ... 52 2e-05
UniRef50_Q28MR4 Cluster: Dehydrogenase E1 component; n=8; Bacter... 52 2e-05
UniRef50_Q1ARM0 Cluster: Pyruvate dehydrogenase; n=3; Bacteria|R... 52 2e-05
UniRef50_Q1KSF1 Cluster: Apicoplast pyruvate dehydrogenase E1 al... 52 2e-05
UniRef50_Q1XDM0 Cluster: Pyruvate dehydrogenase E1 component sub... 52 2e-05
UniRef50_A0HHH5 Cluster: Dehydrogenase, E1 component; n=2; Bacte... 51 4e-05
UniRef50_A4AFX0 Cluster: Acetoin dehydrogenase (TPP-dependent) a... 50 5e-05
UniRef50_Q3DZ88 Cluster: Dehydrogenase, E1 component; n=1; Chlor... 50 7e-05
UniRef50_A0UXT3 Cluster: Pyruvate dehydrogenase; n=1; Clostridiu... 50 9e-05
UniRef50_Q3J9C5 Cluster: Dehydrogenase, E1 component; n=3; Prote... 49 1e-04
UniRef50_Q1NYL5 Cluster: Pyruvate dehydrogenase E1 component alp... 49 2e-04
UniRef50_A3CMZ3 Cluster: Pyruvate dehydrogenase, TPP-dependent E... 49 2e-04
UniRef50_Q7V0M7 Cluster: Dehydrogenase, E1 component; n=1; Proch... 48 2e-04
UniRef50_Q13GQ3 Cluster: Putative 2-oxo acid dehydrogenase alpha... 48 2e-04
UniRef50_A6Q3I6 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 48 3e-04
UniRef50_A4X7T3 Cluster: Dehydrogenase, E1 component; n=3; Actin... 47 5e-04
UniRef50_Q97YF6 Cluster: Pyruvate dehydrogenase, alpha subunit (... 46 0.001
UniRef50_P27745 Cluster: Acetoin:2,6-dichlorophenolindophenol ox... 46 0.002
UniRef50_Q83X26 Cluster: Probable pyruvate dehydrogenase alpha-s... 45 0.002
UniRef50_A0LFE6 Cluster: Pyruvate dehydrogenase; n=1; Syntrophob... 45 0.002
UniRef50_Q0LRY7 Cluster: Dehydrogenase, E1 component:Transketola... 45 0.003
UniRef50_A6UDY5 Cluster: Dehydrogenase E1 component; n=2; Alphap... 44 0.003
UniRef50_Q8YDG0 Cluster: 2-OXOISOVALERATE DEHYDROGENASE BETA SUB... 44 0.005
UniRef50_A5V557 Cluster: Pyruvate dehydrogenase; n=1; Sphingomon... 44 0.006
UniRef50_A5U0N1 Cluster: Dehydrogenase E1 component; n=7; Mycoba... 43 0.008
UniRef50_A4VXG8 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 43 0.008
UniRef50_Q2BFQ9 Cluster: Putative uncharacterized protein; n=1; ... 43 0.011
UniRef50_Q00TN9 Cluster: Pyruvate dehydrogenase E1 component bet... 43 0.011
UniRef50_A5V4J0 Cluster: Pyruvate dehydrogenase; n=2; Sphingomon... 42 0.014
UniRef50_A3SJ75 Cluster: 2-oxoisovalerate dehydrogenase beta sub... 42 0.014
UniRef50_A0JUQ5 Cluster: Pyruvate dehydrogenase; n=4; Actinobact... 42 0.014
UniRef50_Q319T4 Cluster: Pyruvate dehydrogenase; n=1; Prochloroc... 42 0.019
UniRef50_Q98FT3 Cluster: Acetoin dehydrogenase (TPP-dependent) a... 41 0.033
UniRef50_Q7N3C2 Cluster: Similar to 3-methyl-2-oxobutanoate dehy... 41 0.033
UniRef50_Q8YDW3 Cluster: 2-OXOISOVALERATE DEHYDROGENASE BETA SUB... 41 0.043
UniRef50_Q479Q2 Cluster: Dehydrogenase, E1 component; n=2; Rhodo... 41 0.043
UniRef50_Q53610 Cluster: Branched-chain alpha-keto acid dehydrog... 40 0.057
UniRef50_Q0ET31 Cluster: Dehydrogenase, E1 component; n=1; Therm... 40 0.057
UniRef50_Q3WCG3 Cluster: Pyruvate dehydrogenase; n=4; Actinomyce... 40 0.075
UniRef50_A7HBV0 Cluster: 3-methyl-2-oxobutanoate dehydrogenase; ... 40 0.075
UniRef50_A6WG12 Cluster: Pyruvate dehydrogenase; n=3; Actinomyce... 40 0.075
UniRef50_Q0RLC2 Cluster: Pyruvate dehydrogenase E1 component, al... 39 0.13
UniRef50_A0H3S4 Cluster: Putative uncharacterized protein; n=1; ... 39 0.13
UniRef50_Q11G20 Cluster: Twin-arginine translocation pathway sig... 39 0.17
UniRef50_Q9HN77 Cluster: Pyruvate dehydrogenase alpha subunit; n... 38 0.23
UniRef50_Q9NYV4 Cluster: Cell division cycle 2-related protein k... 38 0.30
UniRef50_Q18CB6 Cluster: Acetoin:2,6-dichlorophenolindophenol ox... 38 0.40
UniRef50_Q0RVK8 Cluster: Probable pyruvate dehydrogenase; n=1; R... 38 0.40
UniRef50_Q0MX87 Cluster: Acetoin dehydrogenase alpha-subunit; n=... 38 0.40
UniRef50_Q41071 Cluster: Arabinogalactan-like protein; n=2; Pina... 38 0.40
UniRef50_A1SN84 Cluster: Pyruvate dehydrogenase; n=12; Bacteria|... 37 0.53
UniRef50_Q5VST9 Cluster: Obscurin; n=50; Amniota|Rep: Obscurin -... 37 0.53
UniRef50_Q748I3 Cluster: Dehydrogenase, E1 component, alpha and ... 37 0.70
UniRef50_Q8D6Q7 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 36 0.93
UniRef50_A6CP23 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 36 0.93
UniRef50_Q6A611 Cluster: Pyruvate dehydrogenase E1 component, al... 36 1.2
UniRef50_Q49108 Cluster: Pyruvate dehydrogenase EI alpha subunit... 36 1.2
UniRef50_Q1LFS5 Cluster: Dehydrogenase, E1 component; n=22; Prot... 36 1.2
UniRef50_A4XHV5 Cluster: Transketolase, central region; n=3; Bac... 36 1.2
UniRef50_A1UJ85 Cluster: Pyruvate dehydrogenase; n=16; Mycobacte... 36 1.6
UniRef50_A7D3P2 Cluster: Pyruvate dehydrogenase; n=1; Halorubrum... 36 1.6
UniRef50_UPI00015B6257 Cluster: PREDICTED: similar to chromodoma... 35 2.1
UniRef50_UPI000069F43F Cluster: Short transient receptor potenti... 35 2.1
UniRef50_Q5SJR9 Cluster: Pyruvate dehydrogenase (Lipoamide) (EC ... 35 2.1
UniRef50_A3RZM3 Cluster: Pyruvate dehydrogenase E1 component alp... 35 2.1
UniRef50_A6SG69 Cluster: Putative uncharacterized protein; n=2; ... 35 2.1
UniRef50_Q93N50 Cluster: Pyruvate dehydrogenase alpha subunit; n... 35 2.8
UniRef50_Q83DQ6 Cluster: Dehydrogenase, E1 component, alpha subu... 35 2.8
UniRef50_A7K3C9 Cluster: Dehydrogenase E1 component superfamily;... 35 2.8
UniRef50_Q16ZU1 Cluster: Putative uncharacterized protein; n=2; ... 35 2.8
UniRef50_Q7S5L7 Cluster: Predicted protein; n=1; Neurospora cras... 34 3.7
UniRef50_Q8U4T5 Cluster: 2-oxo acid dehydrogenase subunit E1; n=... 34 3.7
UniRef50_Q9P2K3 Cluster: REST corepressor 3; n=25; Tetrapoda|Rep... 34 3.7
UniRef50_Q756F4 Cluster: DNA repair and recombination protein RA... 34 3.7
UniRef50_UPI00005103B4 Cluster: COG1071: Pyruvate/2-oxoglutarate... 34 4.9
UniRef50_Q9VEJ1 Cluster: CG5836-PA; n=10; Eumetazoa|Rep: CG5836-... 34 4.9
UniRef50_A4RA81 Cluster: Putative uncharacterized protein; n=1; ... 34 4.9
UniRef50_A0LLM4 Cluster: Pyruvate dehydrogenase; n=1; Syntrophob... 33 6.5
UniRef50_Q9W554 Cluster: CG14814-PB, isoform B; n=5; Sophophora|... 33 6.5
UniRef50_Q2Y5G9 Cluster: TonB-like; n=1; Nitrosospira multiformi... 33 8.6
UniRef50_Q9RPS5 Cluster: TPP-dependent branched-chain alpha-keto... 33 8.6
UniRef50_A6X0T5 Cluster: Putative uncharacterized protein; n=1; ... 33 8.6
UniRef50_A4T104 Cluster: Conserved hypothetical proline rich pro... 33 8.6
UniRef50_A0K283 Cluster: Pyruvate dehydrogenase; n=4; Actinobact... 33 8.6
UniRef50_A6NGB9 Cluster: Uncharacterized protein WIPF3; n=17; Th... 33 8.6
UniRef50_Q4PDN8 Cluster: Putative uncharacterized protein; n=1; ... 33 8.6
>UniRef50_P26267 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha type I, mitochondrial precursor; n=10;
cellular organisms|Rep: Pyruvate dehydrogenase E1
component subunit alpha type I, mitochondrial precursor
- Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Length = 396
Score = 127 bits (307), Expect = 3e-28
Identities = 54/89 (60%), Positives = 69/89 (77%)
Frame = +3
Query: 243 RNQAYKLHKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSG 422
+ + +KLHKLD GP + +T EDA+ Y Q+ +RR+E+A+GNLYKEK +RGFCHLYSG
Sbjct: 33 QTKPFKLHKLDSGPDINVHVTKEDAVHYYTQMLTIRRMESAAGNLYKEKKVRGFCHLYSG 92
Query: 423 QEAVAVGMRAAMRDADSVITAYRCHGWTY 509
QEA AVG +AAM D+ +TAYRCHGWTY
Sbjct: 93 QEACAVGTKAAMDAGDAAVTAYRCHGWTY 121
Score = 74.9 bits (176), Expect = 2e-12
Identities = 33/46 (71%), Positives = 36/46 (78%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVXFAHKYRAD 691
R TG GKGGSMH+YG NFYGGNGIVGAQ PLG G+ FA KYR +
Sbjct: 137 RITGNVYGKGGSMHMYGENFYGGNGIVGAQQPLGTGIAFAMKYRKE 182
Score = 54.8 bits (126), Expect = 2e-06
Identities = 23/59 (38%), Positives = 33/59 (55%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
P+G+ + + + V ++GDGA NQGQL S NM KLWDLP ++V +G
Sbjct: 168 PLGTGIAFAMKYRKEKNVCITMFGDGATNQGQLFESMNMAKLWDLPVLYVCENNGYGMG 226
>UniRef50_Q9W4H4 Cluster: CG7024-PA; n=2; Sophophora|Rep: CG7024-PA
- Drosophila melanogaster (Fruit fly)
Length = 479
Score = 120 bits (289), Expect = 4e-26
Identities = 52/85 (61%), Positives = 63/85 (74%)
Frame = +3
Query: 255 YKLHKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAV 434
+K + L+ GP L+ EDAL +Y Q+ LRR ET +GN YKE+ IRGFCHLY+GQEAV
Sbjct: 43 FKCYDLENGPTMDVELSREDALTMYTQMLELRRFETVAGNYYKERKIRGFCHLYNGQEAV 102
Query: 435 AVGMRAAMRDADSVITAYRCHGWTY 509
AVGM+ +R DSVITAYRCH WTY
Sbjct: 103 AVGMKQRLRSCDSVITAYRCHAWTY 127
Score = 85.8 bits (203), Expect = 1e-15
Identities = 36/45 (80%), Positives = 38/45 (84%)
Frame = +2
Query: 557 RTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVXFAHKYRAD 691
RTGCSRGKGGSMH+Y FYGGNGIVGAQVPLGAG+ AH YR D
Sbjct: 144 RTGCSRGKGGSMHMYSDKFYGGNGIVGAQVPLGAGIGLAHSYRKD 188
Score = 66.9 bits (156), Expect = 6e-10
Identities = 29/59 (49%), Positives = 37/59 (62%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
P+G+ GL + GV+ LYGDGAANQGQ+ S+NM KLW LPC+FV +G
Sbjct: 174 PLGAGIGLAHSYRKDNGVSVVLYGDGAANQGQIFESFNMAKLWCLPCIFVCENNHYGMG 232
>UniRef50_UPI0000E4A5CB Cluster: PREDICTED: hypothetical protein,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: hypothetical protein, partial -
Strongylocentrotus purpuratus
Length = 378
Score = 113 bits (271), Expect = 7e-24
Identities = 47/85 (55%), Positives = 64/85 (75%)
Frame = +3
Query: 255 YKLHKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAV 434
+KLHKL++GP ++ LT ++AL Y ++ +RR+ETA+ LYK K +RGFCHLYSGQEA
Sbjct: 166 FKLHKLEEGPKKTSVLTKDEALDYYHKMQTIRRMETAAATLYKSKEVRGFCHLYSGQEAC 225
Query: 435 AVGMRAAMRDADSVITAYRCHGWTY 509
AVG+ + + D+VITAYR HGW Y
Sbjct: 226 AVGISSVLTPDDAVITAYRAHGWAY 250
Score = 81.8 bits (193), Expect = 2e-14
Identities = 34/43 (79%), Positives = 39/43 (90%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVXFAHKY 682
RRTGC++GKGGSMH+Y +NFYGGNGIVGAQVPLGAG+ A KY
Sbjct: 266 RRTGCAKGKGGSMHMYCKNFYGGNGIVGAQVPLGAGIALALKY 308
Score = 65.7 bits (153), Expect = 1e-09
Identities = 27/59 (45%), Positives = 38/59 (64%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
P+G+ L + ++ V +LYGDGAANQGQ+ +YN+ KLWDLPC+FV +G
Sbjct: 297 PLGAGIALALKYTDKKNVCISLYGDGAANQGQVFEAYNIAKLWDLPCIFVCENNKYGMG 355
>UniRef50_Q6NX32 Cluster: Pyruvate dehydrogenase (Lipoamide) alpha
1; n=3; Tetrapoda|Rep: Pyruvate dehydrogenase
(Lipoamide) alpha 1 - Xenopus tropicalis (Western clawed
frog) (Silurana tropicalis)
Length = 369
Score = 105 bits (253), Expect = 1e-21
Identities = 45/84 (53%), Positives = 60/84 (71%)
Frame = +3
Query: 261 LHKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAV 440
+H+L++GP T A LT E L+ Y + +RR+E S LYK+KIIRGFCHLY GQEA V
Sbjct: 53 VHRLEEGPPTQAVLTREQGLQYYRTMQTIRRMELKSDQLYKQKIIRGFCHLYDGQEACCV 112
Query: 441 GMRAAMRDADSVITAYRCHGWTYS 512
G+ AA+ D +ITAYR HG++Y+
Sbjct: 113 GLEAAINPTDHLITAYRAHGYSYT 136
Score = 61.7 bits (143), Expect = 2e-08
Identities = 24/30 (80%), Positives = 28/30 (93%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNFYGGNGIVGAQ 643
RR GC++GKGGSMH+Y +NFYGGNGIVGAQ
Sbjct: 151 RRGGCAKGKGGSMHMYAKNFYGGNGIVGAQ 180
Score = 38.3 bits (85), Expect = 0.23
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Frame = +1
Query: 715 GDGAAN-QGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
G+G QGQ+ +YNM LW LPC+F+ +G
Sbjct: 173 GNGIVGAQGQIFETYNMAALWKLPCIFICENNRYGMG 209
>UniRef50_Q4T3C0 Cluster: Chromosome undetermined SCAF10102, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF10102,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 491
Score = 103 bits (247), Expect = 5e-21
Identities = 67/173 (38%), Positives = 87/173 (50%), Gaps = 23/173 (13%)
Frame = +3
Query: 249 QAYKLHKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQE 428
Q LH+L++GP A LT E L+ Y + +RR+E + LYK+KIIRGFCHLY GQE
Sbjct: 1 QKCDLHRLEEGPPEKAELTREQGLQYYRTMQTIRRMELKADQLYKQKIIRGFCHLYDGQE 60
Query: 429 AVAVGMRAAMRDADSVITAYRCHGWTYSWAL----VCWGCSRS*RGAGP----------- 563
A A G+ AA+ +D +ITAYR HG+T++ + + + G P
Sbjct: 61 ACAAGIEAAITPSDHLITAYRAHGYTFTRGVSVKEILAELTGETGGTFPSSLVPQRLHRS 120
Query: 564 ----VAPGA----REVPCICTDATSMVATGLLVRRSRWELEWXSPTSTAPTGS 698
VA GA + C CT S AT R WELE P ST T S
Sbjct: 121 LPPQVAEGAWPKAKGALCTCTRLISTEATASWELRFLWELELLWPASTRETSS 173
>UniRef50_P08559 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha, somatic form, mitochondrial precursor;
n=110; cellular organisms|Rep: Pyruvate dehydrogenase E1
component subunit alpha, somatic form, mitochondrial
precursor - Homo sapiens (Human)
Length = 390
Score = 101 bits (242), Expect = 2e-20
Identities = 44/87 (50%), Positives = 59/87 (67%)
Frame = +3
Query: 261 LHKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAV 440
LH+L++GP + LT ED LK Y + +RR+E + LYK+KIIRGFCHL GQEA V
Sbjct: 43 LHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCV 102
Query: 441 GMRAAMRDADSVITAYRCHGWTYSWAL 521
G+ A + D +ITAYR HG+T++ L
Sbjct: 103 GLEAGINPTDHLITAYRAHGFTFTRGL 129
Score = 80.2 bits (189), Expect = 6e-14
Identities = 33/48 (68%), Positives = 39/48 (81%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVXFAHKYRADGE 697
R+ GC++GKGGSMH+Y +NFYGGNGIVGAQVPLGAG+ A KY E
Sbjct: 141 RKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDE 188
Score = 58.4 bits (135), Expect = 2e-07
Identities = 25/59 (42%), Positives = 34/59 (57%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
P+G+ L + + V LYGDGAANQGQ+ +YNM LW LPC+F+ +G
Sbjct: 172 PLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMG 230
>UniRef50_Q23KL2 Cluster: Pyruvate dehydrogenase E1 component; n=5;
Intramacronucleata|Rep: Pyruvate dehydrogenase E1
component - Tetrahymena thermophila SB210
Length = 429
Score = 91.5 bits (217), Expect = 2e-17
Identities = 40/75 (53%), Positives = 53/75 (70%)
Frame = +3
Query: 288 TSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDA 467
T +T T E+ LKLY+ + ++R+IE A LYK++ IRGFCHLY GQEAV G+ AA
Sbjct: 87 TQSTATKEELLKLYKDMNVMRKIELACDKLYKQREIRGFCHLYDGQEAVISGIEAACNLE 146
Query: 468 DSVITAYRCHGWTYS 512
D++ITAYRCH Y+
Sbjct: 147 DAIITAYRCHCHAYT 161
Score = 66.1 bits (154), Expect = 1e-09
Identities = 30/45 (66%), Positives = 37/45 (82%), Gaps = 2/45 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVXFAHKY 682
R+TG + GKGGSMH Y + +FYGG+GIVGAQVP+GAG+ FA KY
Sbjct: 176 RKTGSTGGKGGSMHFYRKKTHFYGGHGIVGAQVPMGAGLAFALKY 220
Score = 57.2 bits (132), Expect = 5e-07
Identities = 23/59 (38%), Positives = 36/59 (61%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
P+G+ + ++ V+ +YGDGAANQGQ+ + NM LW+LPC+FV + +G
Sbjct: 209 PMGAGLAFALKYEKKPNVSITMYGDGAANQGQIAEAANMAGLWNLPCLFVCENNLYGMG 267
>UniRef50_Q1EGI2 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=6; Spirotrichea|Rep: Pyruvate dehydrogenase E1 alpha
subunit - Euplotes sp. BB-2004
Length = 389
Score = 87.0 bits (206), Expect = 5e-16
Identities = 38/82 (46%), Positives = 54/82 (65%), Gaps = 1/82 (1%)
Frame = +3
Query: 255 YKLHKLDQGPA-TSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEA 431
+K+H++++ T AT T + L Y+ + ++RR+E S LYK K IRGFCHLY GQE+
Sbjct: 34 FKVHRIEESELPTKATTTKSELLNYYKDMALMRRVEIVSDMLYKNKWIRGFCHLYDGQES 93
Query: 432 VAVGMRAAMRDADSVITAYRCH 497
+ VGM AA+ D +I AYR H
Sbjct: 94 ITVGMEAALTMEDHIINAYRDH 115
Score = 68.9 bits (161), Expect = 1e-10
Identities = 33/50 (66%), Positives = 35/50 (70%), Gaps = 2/50 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLY--GRNFYGGNGIVGAQVPLGAGVXFAHKYRADGE 697
R TG S+GKGGSMH Y NFYGGNGIVGAQVP+G GV F KY E
Sbjct: 135 RSTGSSKGKGGSMHYYCSKNNFYGGNGIVGAQVPVGTGVAFGIKYEGKKE 184
Score = 51.2 bits (117), Expect = 3e-05
Identities = 23/59 (38%), Positives = 33/59 (55%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
PVG+ + ++ V A+YGDGAANQGQ+ + NM LW LP ++ A+G
Sbjct: 168 PVGTGVAFGIKYEGKKEVCVAMYGDGAANQGQIYEAANMAGLWKLPIIYTCENNKYAMG 226
>UniRef50_Q9R9N5 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=62; Bacteria|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Rhizobium
meliloti (Sinorhizobium meliloti)
Length = 348
Score = 86.2 bits (204), Expect = 9e-16
Identities = 42/86 (48%), Positives = 52/86 (60%)
Frame = +3
Query: 243 RNQAYKLHKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSG 422
R A K K D T A + ED LK Y ++ ++RR E +G LY I GFCHLY G
Sbjct: 12 RKTAAKPAKKDFAGGTIAEFSKEDDLKAYREMLLIRRFEEKAGQLYGMGFIGGFCHLYIG 71
Query: 423 QEAVAVGMRAAMRDADSVITAYRCHG 500
QEAV VGM+ A+++ D VIT YR HG
Sbjct: 72 QEAVVVGMQLALKEGDQVITGYRDHG 97
Score = 66.1 bits (154), Expect = 1e-09
Identities = 29/48 (60%), Positives = 39/48 (81%), Gaps = 2/48 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVXFAHKYRAD 691
RR G S+GKGGSMH++ + +FYGG+GIVGAQV LG G+ FA++YR +
Sbjct: 116 RRGGLSKGKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANRYRGN 163
Score = 50.4 bits (115), Expect = 5e-05
Identities = 20/42 (47%), Positives = 28/42 (66%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
V+ A +GDGAANQGQ+ S+NM LW LP +++ A+G
Sbjct: 166 VSLAYFGDGAANQGQVYESFNMAALWKLPVIYIVENNRYAMG 207
>UniRef50_Q8H1Y0 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha-2, mitochondrial precursor; n=33; cellular
organisms|Rep: Pyruvate dehydrogenase E1 component
subunit alpha-2, mitochondrial precursor - Arabidopsis
thaliana (Mouse-ear cress)
Length = 393
Score = 86.2 bits (204), Expect = 9e-16
Identities = 38/76 (50%), Positives = 54/76 (71%)
Frame = +3
Query: 270 LDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMR 449
L + P+ S +SE+ L + + +RR+E A+ +LYK K+IRGFCHLY GQEA+AVGM
Sbjct: 48 LCESPSRSVETSSEEILAFFRDMARMRRMEIAADSLYKAKLIRGFCHLYDGQEALAVGME 107
Query: 450 AAMRDADSVITAYRCH 497
AA+ D++IT+YR H
Sbjct: 108 AAITKKDAIITSYRDH 123
Score = 74.1 bits (174), Expect = 4e-12
Identities = 32/48 (66%), Positives = 38/48 (79%), Gaps = 2/48 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVXFAHKYRAD 691
R+TGCS GKGGSMH Y ++ FYGG+GIVGAQ+PLG G+ FA KY D
Sbjct: 143 RKTGCSHGKGGSMHFYKKDASFYGGHGIVGAQIPLGCGLAFAQKYNKD 190
Score = 57.6 bits (133), Expect = 4e-07
Identities = 26/59 (44%), Positives = 33/59 (55%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
P+G + + VTFALYGDGAANQGQL + N+ LWDLP + V +G
Sbjct: 176 PLGCGLAFAQKYNKDEAVTFALYGDGAANQGQLFEALNISALWDLPAILVCENNHYGMG 234
>UniRef50_A2QWB4 Cluster: Catalytic activity: Pyruvate + Lipoamide
<=> S-Acetyldihydrolipoamide + CO2; n=3; Ascomycota|Rep:
Catalytic activity: Pyruvate + Lipoamide <=>
S-Acetyldihydrolipoamide + CO2 - Aspergillus niger
Length = 403
Score = 85.4 bits (202), Expect = 2e-15
Identities = 41/89 (46%), Positives = 59/89 (66%)
Frame = +3
Query: 240 IRNQAYKLHKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYS 419
I + +++ + LD P + T T +LY ++++RR+E A+ LYKE+ IRGFCHL +
Sbjct: 49 IADDSFETYNLDPPPYSLET-TKSQLKQLYYDMSLIRRMELAADKLYKEQKIRGFCHLST 107
Query: 420 GQEAVAVGMRAAMRDADSVITAYRCHGWT 506
GQEAVAVG+ + D VITAYR HG+T
Sbjct: 108 GQEAVAVGVEHGISPEDKVITAYRAHGFT 136
Score = 66.5 bits (155), Expect = 8e-10
Identities = 26/43 (60%), Positives = 34/43 (79%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVXFAHKY 682
RR G GKGGS+H++ +NF+GGNGIVG+ VPLG G+ FA +Y
Sbjct: 153 RRDGICHGKGGSVHMFTKNFFGGNGIVGSNVPLGTGIAFAQQY 195
Score = 57.2 bits (132), Expect = 5e-07
Identities = 26/59 (44%), Positives = 34/59 (57%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
P+G+ Q + VT LYGDGAANQGQ+ +YNM KLW+LP +F +G
Sbjct: 184 PLGTGIAFAQQYDDTKKVTVNLYGDGAANQGQVHEAYNMAKLWELPVIFGCENNKYGMG 242
>UniRef50_P16387 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha, mitochondrial precursor; n=34;
Dikarya|Rep: Pyruvate dehydrogenase E1 component subunit
alpha, mitochondrial precursor - Saccharomyces
cerevisiae (Baker's yeast)
Length = 420
Score = 84.6 bits (200), Expect = 3e-15
Identities = 38/76 (50%), Positives = 52/76 (68%)
Frame = +3
Query: 282 PATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMR 461
P S + L++Y+ + I+RR+E A LYK K IRGFCHL GQEA+AVG+ A+
Sbjct: 70 PDLSYETSKATLLQMYKDMVIIRRMEMACDALYKAKKIRGFCHLSVGQEAIAVGIENAIT 129
Query: 462 DADSVITAYRCHGWTY 509
DS+IT+YRCHG+T+
Sbjct: 130 KLDSIITSYRCHGFTF 145
Score = 78.6 bits (185), Expect = 2e-13
Identities = 34/44 (77%), Positives = 37/44 (84%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVXFAHKYR 685
RR G S GKGGSMHLY FYGGNGIVGAQVPLGAG+ FAH+Y+
Sbjct: 161 RRAGVSYGKGGSMHLYAPGFYGGNGIVGAQVPLGAGLAFAHQYK 204
Score = 57.6 bits (133), Expect = 4e-07
Identities = 25/59 (42%), Positives = 33/59 (55%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
P+G+ Q +F LYGDGA+NQGQ+ S+NM KLW+LP VF +G
Sbjct: 192 PLGAGLAFAHQYKNEDACSFTLYGDGASNQGQVFESFNMAKLWNLPVVFCCENNKYGMG 250
>UniRef50_Q1EGH8 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=1; Nyctotherus ovalis|Rep: Pyruvate dehydrogenase E1
alpha subunit - Nyctotherus ovalis
Length = 136
Score = 82.2 bits (194), Expect = 1e-14
Identities = 38/89 (42%), Positives = 54/89 (60%), Gaps = 1/89 (1%)
Frame = +3
Query: 237 DIRNQAYKLHKLDQGPA-TSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHL 413
+I+ Y++ LD+ T A ++ LK Y + RR+E +YK+K +RGFCHL
Sbjct: 23 EIKLPQYEVFNLDKSILPTKAQTNRDEMLKYYHDMNFQRRVEIMCDEIYKKKEVRGFCHL 82
Query: 414 YSGQEAVAVGMRAAMRDADSVITAYRCHG 500
GQEAV+VG+ A + D +ITAYRCHG
Sbjct: 83 MDGQEAVSVGVEAGITKEDHLITAYRCHG 111
>UniRef50_O66112 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=38; Proteobacteria|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Zymomonas
mobilis
Length = 354
Score = 75.8 bits (178), Expect = 1e-12
Identities = 34/49 (69%), Positives = 39/49 (79%), Gaps = 2/49 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVXFAHKYRADG 694
R +G S GKGGSMH++ F+GGNGIVGAQVPLGAG+ FAHKYR DG
Sbjct: 120 RASGISHGKGGSMHMFSTEHKFFGGNGIVGAQVPLGAGLAFAHKYRNDG 168
Score = 74.1 bits (174), Expect = 4e-12
Identities = 35/72 (48%), Positives = 49/72 (68%), Gaps = 1/72 (1%)
Frame = +3
Query: 309 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDA-DSVITA 485
E+ L+ Y ++ ++RR E G LY +I GFCHLY GQEAVAVG++AA++ DSVIT
Sbjct: 37 EELLEFYRRMLMIRRFEERCGQLYGLGLIAGFCHLYIGQEAVAVGLQAALQPGRDSVITG 96
Query: 486 YRCHGWTYSWAL 521
YR HG ++ +
Sbjct: 97 YREHGHMLAYGI 108
Score = 51.2 bits (117), Expect = 3e-05
Identities = 23/59 (38%), Positives = 33/59 (55%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
P+G+ + G + A +GDG+ANQGQ+ +YNM LW LP +FV A+G
Sbjct: 153 PLGAGLAFAHKYRNDGGCSAAYFGDGSANQGQVYEAYNMAALWKLPVIFVIENNGYAMG 211
>UniRef50_O96865 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=2; Trypanosoma cruzi|Rep: Pyruvate dehydrogenase E1
alpha subunit - Trypanosoma cruzi
Length = 378
Score = 73.3 bits (172), Expect = 7e-12
Identities = 39/87 (44%), Positives = 50/87 (57%), Gaps = 4/87 (4%)
Frame = +3
Query: 255 YKLHKL---DQGPA-TSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSG 422
+KLH D P T+AT +E K E + +RR+E+ YK K IRGFCHLY G
Sbjct: 23 FKLHTAGRDDVPPVPTTATYDTEQMKKCLEMMFRIRRMESLCDQSYKLKKIRGFCHLYIG 82
Query: 423 QEAVAVGMRAAMRDADSVITAYRCHGW 503
QEA+ VGM + D ++TAYR H W
Sbjct: 83 QEAIPVGMENVLTLEDLIVTAYRDHAW 109
Score = 64.1 bits (149), Expect = 4e-09
Identities = 27/36 (75%), Positives = 32/36 (88%), Gaps = 2/36 (5%)
Frame = +2
Query: 563 GCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGV 664
GCS+GKGGSMH+Y NF+GGNGIVGAQVP+GAG+
Sbjct: 130 GCSKGKGGSMHMYSVKNNFFGGNGIVGAQVPIGAGL 165
Score = 41.9 bits (94), Expect = 0.019
Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 3/62 (4%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRR---RGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTA 816
P+G+ G R + R R V YGDGAANQGQ+ + N+ + +P +F
Sbjct: 160 PIGAGLGWRFALENRDKPRNVAVTFYGDGAANQGQVFEAMNIAAIHRIPVIFCCENNQFG 219
Query: 817 LG 822
+G
Sbjct: 220 MG 221
>UniRef50_Q4WHM5 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit, putative; n=1; Aspergillus fumigatus|Rep:
Pyruvate dehydrogenase E1 component alpha subunit,
putative - Aspergillus fumigatus (Sartorya fumigata)
Length = 360
Score = 70.1 bits (164), Expect = 6e-11
Identities = 31/54 (57%), Positives = 41/54 (75%)
Frame = +3
Query: 348 RRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCHGWTY 509
+R+E A+ LYK+K IRGFCHL +GQEAVAVG+ + D +ITAYR HG+T+
Sbjct: 81 QRLEIAADALYKQKKIRGFCHLSTGQEAVAVGIEYGISKEDKLITAYRSHGFTF 134
Score = 66.1 bits (154), Expect = 1e-09
Identities = 27/43 (62%), Positives = 34/43 (79%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVXFAHKY 682
R+ G S GKGGSMH++ F+GGNGIVGA VP+GAG+ FA +Y
Sbjct: 150 RQDGISHGKGGSMHMFCAGFFGGNGIVGAHVPVGAGIAFAQQY 192
Score = 54.0 bits (124), Expect = 4e-06
Identities = 24/49 (48%), Positives = 31/49 (63%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVF 792
PVG+ Q R +T YGDGAANQGQ+ ++NM KLW+LP +F
Sbjct: 181 PVGAGIAFAQQYNDRDNITVDAYGDGAANQGQVHEAFNMAKLWNLPVLF 229
>UniRef50_A6DTS3 Cluster: Dehydrogenase complex, E1 component, alpha
subunit; n=1; Lentisphaera araneosa HTCC2155|Rep:
Dehydrogenase complex, E1 component, alpha subunit -
Lentisphaera araneosa HTCC2155
Length = 320
Score = 69.7 bits (163), Expect = 8e-11
Identities = 31/63 (49%), Positives = 41/63 (65%)
Frame = +3
Query: 309 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAY 488
E AL++ EQ+ +RR E Y++K I GFCH Y GQEAVAVG A + D+ +T+Y
Sbjct: 7 EKALQMLEQMIRVRRFEEGCLKSYQQKFITGFCHTYIGQEAVAVGAMAHLTPTDAYVTSY 66
Query: 489 RCH 497
RCH
Sbjct: 67 RCH 69
Score = 61.7 bits (143), Expect = 2e-08
Identities = 26/43 (60%), Positives = 33/43 (76%), Gaps = 2/43 (4%)
Frame = +2
Query: 560 TGCSRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVXFAHKY 682
TGC RGKGGSMH++ + N+ GG+GIVG Q+P+G G FA KY
Sbjct: 91 TGCVRGKGGSMHVFSKKNNYLGGHGIVGGQIPIGLGAAFALKY 133
Score = 46.4 bits (105), Expect = 9e-04
Identities = 18/59 (30%), Positives = 29/59 (49%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
P+G + + + GV +GDGA+ QG S N+ LWD+P +F+ +G
Sbjct: 122 PIGLGAAFALKYEEKEGVALTFFGDGASMQGTFHESLNLASLWDVPVIFICENNQYGMG 180
>UniRef50_Q5FNM5 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=4; Bacteria|Rep: Pyruvate dehydrogenase E1
component alpha subunit - Gluconobacter oxydans
(Gluconobacter suboxydans)
Length = 334
Score = 69.3 bits (162), Expect = 1e-10
Identities = 32/74 (43%), Positives = 43/74 (58%)
Frame = +3
Query: 279 GPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAM 458
G + L+ E + Y + ++RR E +G LY +I GFCHLY GQEAV VG+ M
Sbjct: 9 GRSNGPALSPETMKRAYRDMLLVRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGIGLNM 68
Query: 459 RDADSVITAYRCHG 500
+ D IT+YR HG
Sbjct: 69 KQGDKSITSYRDHG 82
Score = 65.3 bits (152), Expect = 2e-09
Identities = 31/50 (62%), Positives = 36/50 (72%), Gaps = 2/50 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVXFAHKYRADGE 697
R G S GKGGSMH++ R FYGG+GIVGAQV LG G+ FA+KYR E
Sbjct: 101 RSGGYSHGKGGSMHMFSREKEFYGGHGIVGAQVALGTGLAFANKYRGTDE 150
Score = 38.7 bits (86), Expect = 0.17
Identities = 15/42 (35%), Positives = 25/42 (59%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
V+ +G+GA+ QGQ+ S+N+ L LPC++V +G
Sbjct: 151 VSIVYFGEGASAQGQVYESFNLAALHKLPCIYVIENNRYGMG 192
>UniRef50_Q4QDQ1 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit, putative; n=5; Euglenozoa|Rep: Pyruvate
dehydrogenase E1 component alpha subunit, putative -
Leishmania major
Length = 378
Score = 68.9 bits (161), Expect = 1e-10
Identities = 37/90 (41%), Positives = 48/90 (53%), Gaps = 4/90 (4%)
Frame = +3
Query: 255 YKLH---KLDQGPATSATLTSEDALKLYEQLTI-LRRIETASGNLYKEKIIRGFCHLYSG 422
+KLH + D P + + + LK L +RR+E+ YK K IRGFCHLY G
Sbjct: 23 FKLHTAGRTDMAPLPTQAVYDAEQLKQSLALMFRIRRMESLCDQSYKLKKIRGFCHLYIG 82
Query: 423 QEAVAVGMRAAMRDADSVITAYRCHGWTYS 512
QEA+ GM + D +IT YR HGW S
Sbjct: 83 QEAIPAGMENVLTFEDPIITGYRDHGWYIS 112
Score = 61.3 bits (142), Expect = 3e-08
Identities = 27/39 (69%), Positives = 32/39 (82%), Gaps = 2/39 (5%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLY--GRNFYGGNGIVGAQVPLGAGV 664
R+ GCS+GKGGSMH+Y FYGGNGIVGAQV +GAG+
Sbjct: 127 RQGGCSKGKGGSMHMYRVDNGFYGGNGIVGAQVSIGAGL 165
Score = 41.9 bits (94), Expect = 0.019
Identities = 21/47 (44%), Positives = 26/47 (55%)
Frame = +1
Query: 682 PRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
P+ VTF YGDGAANQGQ+ S N+ L LP +F +G
Sbjct: 177 PKHVAVTF--YGDGAANQGQIYESMNIAALQRLPVIFAVENNHFGMG 221
>UniRef50_Q74AD3 Cluster: Dehydrogenase complex, E1 component, alpha
subunit; n=5; Geobacter|Rep: Dehydrogenase complex, E1
component, alpha subunit - Geobacter sulfurreducens
Length = 325
Score = 66.9 bits (156), Expect = 6e-10
Identities = 32/68 (47%), Positives = 43/68 (63%)
Frame = +3
Query: 294 ATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADS 473
A L + LK++EQ+ + R E + Y + I GF HLYSGQEAVAVG AA+R D
Sbjct: 7 AILPDSELLKMHEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAALRKDDY 66
Query: 474 VITAYRCH 497
+++AYR H
Sbjct: 67 ILSAYREH 74
Score = 54.4 bits (125), Expect = 3e-06
Identities = 25/49 (51%), Positives = 32/49 (65%), Gaps = 2/49 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVXFAHKYRADG 694
+ TG +GKGGSMHL+ + F GG IVG Q P+ G+ FA KYR +G
Sbjct: 94 KATGMCKGKGGSMHLFDPSLAFMGGYAIVGGQFPIAVGLAFASKYRKEG 142
Score = 41.5 bits (93), Expect = 0.025
Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Frame = +1
Query: 685 RRRG-VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
R+ G ++ +GDGA NQG S N +LW+LP +F+ +G
Sbjct: 139 RKEGRISACFFGDGAVNQGTFHESLNWARLWELPVLFICENNFYGIG 185
>UniRef50_Q2S150 Cluster: Pyruvate dehydrogenase E1 component, alpha
subunit; n=1; Salinibacter ruber DSM 13855|Rep: Pyruvate
dehydrogenase E1 component, alpha subunit - Salinibacter
ruber (strain DSM 13855)
Length = 470
Score = 66.5 bits (155), Expect = 8e-10
Identities = 30/55 (54%), Positives = 40/55 (72%), Gaps = 2/55 (3%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVXFAHKYRADGESRSLC 712
+ TGCS+GKGGSMH + + GG+ IVGA +PLGAG+ FAHKYR + ++ LC
Sbjct: 231 KETGCSKGKGGSMHFFDAEKKMMGGHAIVGAHLPLGAGLAFAHKYRGE-DNVCLC 284
Score = 56.8 bits (131), Expect = 6e-07
Identities = 31/83 (37%), Positives = 43/83 (51%), Gaps = 1/83 (1%)
Frame = +3
Query: 255 YKLHKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAV 434
Y+ + D + ++ L L + + RR E +Y+ + I GF HLY GQEAV
Sbjct: 130 YETYPADTYGHDELGIADDEVLDLLRNMLLQRRFENRCRQMYQRQKISGFLHLYIGQEAV 189
Query: 435 AVG-MRAAMRDADSVITAYRCHG 500
+ G + A DSVITAYR HG
Sbjct: 190 STGSVNAIELGDDSVITAYRDHG 212
Score = 36.3 bits (80), Expect = 0.93
Identities = 17/59 (28%), Positives = 28/59 (47%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
P+G+ + V +GDGA +QG + N+ +++LP VFV A+G
Sbjct: 264 PLGAGLAFAHKYRGEDNVCLCFFGDGAMHQGAFREACNLAGIYELPIVFVCENNQYAMG 322
>UniRef50_A7CXZ4 Cluster: Pyruvate dehydrogenase; n=1; Opitutaceae
bacterium TAV2|Rep: Pyruvate dehydrogenase - Opitutaceae
bacterium TAV2
Length = 365
Score = 66.5 bits (155), Expect = 8e-10
Identities = 35/70 (50%), Positives = 43/70 (61%)
Frame = +3
Query: 291 SATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDAD 470
+A LT ++LY + +RR E S Y+ K I GF HLY GQEAVAVG + M + D
Sbjct: 28 NADLTPAARIELYRTMVRIRRFEERSLRAYQAKKIGGFLHLYIGQEAVAVGCCSLMGEHD 87
Query: 471 SVITAYRCHG 500
VITAYR HG
Sbjct: 88 HVITAYRDHG 97
Score = 66.1 bits (154), Expect = 1e-09
Identities = 27/46 (58%), Positives = 37/46 (80%), Gaps = 2/46 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLY--GRNFYGGNGIVGAQVPLGAGVXFAHKYR 685
+ TGCS+GKGGSMH + +N++GG+GIVG Q+PLG G+ +A KYR
Sbjct: 116 KATGCSKGKGGSMHYFDPSKNYWGGHGIVGGQIPLGTGLAYAVKYR 161
Score = 52.4 bits (120), Expect = 1e-05
Identities = 29/83 (34%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Frame = +1
Query: 580 GRFHAFVRTQLLWWQRDCWCAGPVGSWSGLRPQVPRR--RGVTFALYGDGAANQGQLLRS 753
G H F ++ W G + +GL V R +G A GDGA NQG + +
Sbjct: 126 GSMHYFDPSKNYWGGHGI-VGGQIPLGTGLAYAVKYRGLKGSAMAFMGDGAVNQGAVHEA 184
Query: 754 YNMLKLWDLPCVFVARTTVTALG 822
YN+ LWDLPC+FV ++G
Sbjct: 185 YNLAALWDLPCIFVIENNGYSMG 207
>UniRef50_Q9Z8N4 Cluster: Pyruvate Dehydrogenase Alpha; n=8;
Chlamydiaceae|Rep: Pyruvate Dehydrogenase Alpha -
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Length = 342
Score = 66.1 bits (154), Expect = 1e-09
Identities = 29/53 (54%), Positives = 35/53 (66%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVXFAHKYRADGESRSLC 712
+ TGC+ G+GGSMH+ G NF GG GIVG Q+PL AG F KY+ SLC
Sbjct: 111 KETGCALGRGGSMHMCGPNFPGGFGIVGGQIPLAAGAAFTIKYQEQKNRVSLC 163
Score = 47.2 bits (107), Expect = 5e-04
Identities = 22/60 (36%), Positives = 32/60 (53%)
Frame = +3
Query: 318 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 497
+K +Q+ ++R E Y E ++ GF H Y+GQEAVA A V ++YRCH
Sbjct: 32 IKFLKQMVLIREFEARGEEAYLEGLVGGFYHSYAGQEAVATAAIANTGLDPWVFSSYRCH 91
>UniRef50_Q8SQM8 Cluster: PYRUVATE DEHYDROGENASE E1 COMPONENT ALPHA
SUBUNIT; n=1; Encephalitozoon cuniculi|Rep: PYRUVATE
DEHYDROGENASE E1 COMPONENT ALPHA SUBUNIT -
Encephalitozoon cuniculi
Length = 349
Score = 66.1 bits (154), Expect = 1e-09
Identities = 26/43 (60%), Positives = 36/43 (83%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVXFAHKY 682
R+ G +GKGGSMHLY ++F+GG+GIVGAQ+PLG G+ +A +Y
Sbjct: 118 RQAGVCKGKGGSMHLYNKSFFGGHGIVGAQIPLGLGMAYALEY 160
Score = 61.7 bits (143), Expect = 2e-08
Identities = 28/67 (41%), Positives = 41/67 (61%)
Frame = +3
Query: 309 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAY 488
+ A+ +Y+Q+ +R ++ A YK K IRGFCHL GQE + + AM D D +++Y
Sbjct: 37 DKAVYIYKQMMRMRCMDEAMDREYKRKNIRGFCHLSIGQEGIYAALEYAM-DGDVAVSSY 95
Query: 489 RCHGWTY 509
RCHG Y
Sbjct: 96 RCHGIAY 102
Score = 50.0 bits (114), Expect = 7e-05
Identities = 21/33 (63%), Positives = 25/33 (75%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFV 795
V +A YGDGAANQGQ+ S+NM +W LP VFV
Sbjct: 172 VCYAFYGDGAANQGQVWESFNMAMVWRLPIVFV 204
>UniRef50_A6GG24 Cluster: Pyruvate dehydrogenase (Lipoamide), alpha
subunit; n=1; Plesiocystis pacifica SIR-1|Rep: Pyruvate
dehydrogenase (Lipoamide), alpha subunit - Plesiocystis
pacifica SIR-1
Length = 339
Score = 64.5 bits (150), Expect = 3e-09
Identities = 29/74 (39%), Positives = 43/74 (58%)
Frame = +3
Query: 282 PATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMR 461
P T + ++ LK + ++ +RR E + Y I GF HLY GQEA+AVG++ AM+
Sbjct: 11 PETLTSAGKDETLKAFREMLRIRRFEETAARAYTRGKISGFLHLYIGQEAIAVGVKLAMQ 70
Query: 462 DADSVITAYRCHGW 503
D V+ YR HG+
Sbjct: 71 ANDRVVGTYRDHGY 84
Score = 44.4 bits (100), Expect = 0.003
Identities = 23/55 (41%), Positives = 32/55 (58%), Gaps = 2/55 (3%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVXFAHKYRADGESRSLC 712
+ TG G GGSMH + R +GG I+G VP+ AG FA KY D ++ ++C
Sbjct: 102 KATGLVGGVGGSMHYFDRPNGLWGGYAIIGNHVPVAAGHAFASKYLGD-DAVTMC 155
>UniRef50_Q1ATM5 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacter
xylanophilus DSM 9941|Rep: Pyruvate dehydrogenase -
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 353
Score = 62.1 bits (144), Expect = 2e-08
Identities = 31/70 (44%), Positives = 43/70 (61%), Gaps = 1/70 (1%)
Frame = +3
Query: 291 SATLTSEDAL-KLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDA 467
SA TS D L +LY ++ ++R E A +++ I G+ H+Y+GQEAVA G A R+
Sbjct: 19 SAVATSPDRLAELYGKMVLIRAFEDACQRAFRQGKIGGYLHVYTGQEAVATGFLEAFREG 78
Query: 468 DSVITAYRCH 497
D VIT YR H
Sbjct: 79 DRVITGYRDH 88
Score = 58.4 bits (135), Expect = 2e-07
Identities = 28/55 (50%), Positives = 36/55 (65%), Gaps = 2/55 (3%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVXFAHKYRADGESRSLC 712
+RTG +GKGGSMHL+ R F GG GIVG +PLG G+ +A +Y G S +C
Sbjct: 108 KRTGLVKGKGGSMHLFDVERGFMGGYGIVGGHIPLGVGIAYALRY---GGSEGIC 159
>UniRef50_Q95VS6 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=2; Antonospora locustae|Rep: Pyruvate dehydrogenase E1
alpha subunit - Antonospora locustae (Nosema locustae)
Length = 342
Score = 62.1 bits (144), Expect = 2e-08
Identities = 27/43 (62%), Positives = 33/43 (76%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVXFAHKY 682
R G ++GKGGSMHLY +GG+GIVGAQVPLG G+ +A KY
Sbjct: 108 RAGGVAKGKGGSMHLYNDLLFGGHGIVGAQVPLGCGMAYALKY 150
Score = 52.8 bits (121), Expect = 1e-05
Identities = 25/69 (36%), Positives = 38/69 (55%)
Frame = +3
Query: 291 SATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDAD 470
S + +D KLY ++ +R ++ + +Y +IRGFCHL GQE V + R+ D
Sbjct: 21 SCKIRYDDVEKLYRKMLCMRYMDESISKMYSRGLIRGFCHLDIGQEEVYAALCHVARN-D 79
Query: 471 SVITAYRCH 497
I +YRCH
Sbjct: 80 KFIGSYRCH 88
Score = 52.0 bits (119), Expect = 2e-05
Identities = 20/35 (57%), Positives = 27/35 (77%)
Frame = +1
Query: 691 RGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFV 795
+ V F YGDGA+NQGQ+ S+N+ K+W+LP VFV
Sbjct: 163 KAVVFCFYGDGASNQGQIHESFNVAKIWNLPIVFV 197
>UniRef50_Q12FH4 Cluster: Pyruvate dehydrogenase; n=37;
Bacteria|Rep: Pyruvate dehydrogenase - Polaromonas sp.
(strain JS666 / ATCC BAA-500)
Length = 337
Score = 59.7 bits (138), Expect = 9e-08
Identities = 29/62 (46%), Positives = 39/62 (62%)
Frame = +3
Query: 315 ALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRC 494
AL + + +RR+E LY E+ IRGF HLY G+EAVAVG A++ D+V+ YR
Sbjct: 21 ALAVLAGMLRIRRMEEKCAQLYGEQKIRGFLHLYIGEEAVAVGALRALQPQDNVVATYRE 80
Query: 495 HG 500
HG
Sbjct: 81 HG 82
Score = 59.7 bits (138), Expect = 9e-08
Identities = 27/44 (61%), Positives = 32/44 (72%), Gaps = 2/44 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVXFAHK 679
+R GCSRG+GGSMHL+ R FYGGN IVG +PL AG+ A K
Sbjct: 101 KREGCSRGRGGSMHLFDRATRFYGGNAIVGGGLPLAAGLALADK 144
Score = 38.7 bits (86), Expect = 0.17
Identities = 21/82 (25%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Frame = +1
Query: 580 GRFHAFVRTQLLWWQRDCWCAG-PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSY 756
G H F R + G P+ + L ++ R+ +T +G+GA +G +
Sbjct: 111 GSMHLFDRATRFYGGNAIVGGGLPLAAGLALADKMAGRQALTACFFGEGAIAEGAFHEAA 170
Query: 757 NMLKLWDLPCVFVARTTVTALG 822
N+ LW LP +F + A+G
Sbjct: 171 NLAALWQLPVLFCCENNLYAMG 192
>UniRef50_A3VIE7 Cluster: Tpp-dependent acetoin dehydrogenase e1
alpha-subunit; n=2; Rhodobacterales|Rep: Tpp-dependent
acetoin dehydrogenase e1 alpha-subunit - Rhodobacterales
bacterium HTCC2654
Length = 335
Score = 59.7 bits (138), Expect = 9e-08
Identities = 31/79 (39%), Positives = 45/79 (56%)
Frame = +3
Query: 264 HKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG 443
H + A S T T ED L++Y Q+ +R E + LY + G H+YSG+EAVAVG
Sbjct: 5 HLREDTMAKSKTNT-EDYLRMYRQMVRIRTFEDNANQLYLSAKMPGLTHMYSGEEAVAVG 63
Query: 444 MRAAMRDADSVITAYRCHG 500
+ A+ D D + + +R HG
Sbjct: 64 ICEALTDDDRITSTHRGHG 82
Score = 38.7 bits (86), Expect = 0.17
Identities = 17/48 (35%), Positives = 25/48 (52%)
Frame = +1
Query: 649 VGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVF 792
+ + S LR ++ VT +GDGA QG + NM LW LP ++
Sbjct: 135 IATGSALRAKLQGSDDVTVCFFGDGATAQGLMYEVMNMAALWKLPVIY 182
>UniRef50_A5UU15 Cluster: Pyruvate dehydrogenase; n=3; Chloroflexi
(class)|Rep: Pyruvate dehydrogenase - Roseiflexus sp.
RS-1
Length = 350
Score = 58.8 bits (136), Expect = 2e-07
Identities = 28/67 (41%), Positives = 37/67 (55%)
Frame = +3
Query: 300 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 479
L + + Y Q+ ++RR E +Y I GF HLY G+EA AVG AA+R D +
Sbjct: 21 LDAATLIDYYRQMVLIRRFEEKCQEMYTRAKIGGFLHLYIGEEATAVGAIAALRPDDHIF 80
Query: 480 TAYRCHG 500
T YR HG
Sbjct: 81 THYRDHG 87
Score = 48.0 bits (109), Expect = 3e-04
Identities = 22/42 (52%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Frame = +2
Query: 560 TGCSRGKGGSMHLY--GRNFYGGNGIVGAQVPLGAGVXFAHK 679
TGCS+G GGSMH +NF+GG IVG+ +PL GV K
Sbjct: 108 TGCSKGLGGSMHFADASKNFWGGYAIVGSHLPLATGVALGMK 149
Score = 48.0 bits (109), Expect = 3e-04
Identities = 21/59 (35%), Positives = 31/59 (52%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
P+ + L ++ R+ V +GDGA N G+ S N +LW LP VFV + A+G
Sbjct: 139 PLATGVALGMKMQRKDSVVMVFFGDGATNGGEFYESLNFAQLWKLPVVFVCENNLYAMG 197
>UniRef50_Q2ITF8 Cluster: Acetoin dehydrogenase (TPP-dependent)
alpha chain; n=1; Rhodopseudomonas palustris HaA2|Rep:
Acetoin dehydrogenase (TPP-dependent) alpha chain -
Rhodopseudomonas palustris (strain HaA2)
Length = 323
Score = 56.0 bits (129), Expect = 1e-06
Identities = 30/69 (43%), Positives = 37/69 (53%), Gaps = 2/69 (2%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVXFAHKYRADGESRSLCTETEP 727
R TGCSRGKGGSMHL + F G IVG VP+G G+ + K + G+ +
Sbjct: 85 RVTGCSRGKGGSMHLIDESAGFMGSTAIVGGTVPVGVGLAYPMKLKRTGQIACVFLGDAV 144
Query: 728 PTRVNFFEA 754
P FFEA
Sbjct: 145 PETGVFFEA 153
Score = 38.7 bits (86), Expect = 0.17
Identities = 22/64 (34%), Positives = 32/64 (50%)
Frame = +3
Query: 306 SEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITA 485
SE +L + +R +E Y E+ +R HL GQEAVA AA+ AD ++
Sbjct: 2 SELPRRLLFDMMRIRAVEETIAKRYGEQKMRCPTHLSVGQEAVAAAAGAALEPADLAVSG 61
Query: 486 YRCH 497
+R H
Sbjct: 62 HRAH 65
>UniRef50_Q5VGY4 Cluster: Pyruvate dehydrogenase alpha subunit; n=6;
Plasmodium|Rep: Pyruvate dehydrogenase alpha subunit -
Plasmodium falciparum
Length = 608
Score = 55.6 bits (128), Expect = 1e-06
Identities = 25/70 (35%), Positives = 40/70 (57%)
Frame = +3
Query: 288 TSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDA 467
+ ++ E+ LYE + + R E LY K + GF HLY+GQEAV+ G+ ++++
Sbjct: 184 SDVNISREEICTLYEDMYLGRLFENLVAKLYYNKRVNGFVHLYNGQEAVSTGIIKNLKNS 243
Query: 468 DSVITAYRCH 497
D V + YR H
Sbjct: 244 DFVTSTYRDH 253
Score = 46.8 bits (106), Expect = 7e-04
Identities = 18/41 (43%), Positives = 29/41 (70%), Gaps = 2/41 (4%)
Frame = +2
Query: 569 SRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVXFAHKYR 685
++GKGGSMH+Y + NF GG G +G Q+P+ G+ ++ Y+
Sbjct: 279 NKGKGGSMHIYSKENNFIGGFGFIGEQIPIAVGLAYSILYK 319
Score = 33.9 bits (74), Expect = 4.9
Identities = 15/42 (35%), Positives = 20/42 (47%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
V GDG N GQ S N+ ++LP +FV A+G
Sbjct: 358 VVVCFLGDGTTNIGQFFESLNLASSYNLPIIFVIENNNWAIG 399
>UniRef50_A0LSF3 Cluster: Pyruvate dehydrogenase; n=5; Bacteria|Rep:
Pyruvate dehydrogenase - Acidothermus cellulolyticus
(strain ATCC 43068 / 11B)
Length = 375
Score = 55.2 bits (127), Expect = 2e-06
Identities = 27/75 (36%), Positives = 39/75 (52%), Gaps = 1/75 (1%)
Frame = +3
Query: 282 PATSATLTSEDALKLY-EQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAM 458
PA D L+ Y + ++RR E + +Y+ I G+CHL G+EA VG+ AM
Sbjct: 29 PADRLAQEPPDKLRAYYRMMQLIRRFEERAAEMYQRAKIGGYCHLNLGEEATVVGLMDAM 88
Query: 459 RDADSVITAYRCHGW 503
D + T YR HG+
Sbjct: 89 APHDYLFTTYREHGY 103
Score = 45.2 bits (102), Expect = 0.002
Identities = 23/46 (50%), Positives = 26/46 (56%), Gaps = 2/46 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVXFAHKYR 685
R TG S+G GGSMHL+ GG GIVG Q+P G A YR
Sbjct: 121 RTTGVSKGWGGSMHLFDAETRLLGGYGIVGGQIPPATGAALAIAYR 166
>UniRef50_A5V540 Cluster: Dehydrogenase, E1 component; n=3;
Proteobacteria|Rep: Dehydrogenase, E1 component -
Sphingomonas wittichii RW1
Length = 334
Score = 54.8 bits (126), Expect = 2e-06
Identities = 25/75 (33%), Positives = 43/75 (57%)
Frame = +3
Query: 276 QGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAA 455
+G A + + ++LY ++ +R E + G L+ I GF HL GQE V+VG+ A+
Sbjct: 10 RGAAHGRNARAPELIELYRRMVTIREAEKSCGALFAAGEIPGFIHLSDGQEGVSVGVMAS 69
Query: 456 MRDADSVITAYRCHG 500
+R D++ + +R HG
Sbjct: 70 LRADDTIASTHRGHG 84
Score = 37.9 bits (84), Expect = 0.30
Identities = 20/52 (38%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Frame = +2
Query: 563 GCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVXFAHKYRADGESRSLC 712
G +G+GGSMH+ + G NGIVG V + G A K R G+ ++C
Sbjct: 106 GACKGRGGSMHVADLSVGMLGANGIVGGGVAIALGSGLAQKLRG-GDGLAIC 156
>UniRef50_Q6MAE2 Cluster: Putative pyruvate dehydrogenase
(Lipoamide), E1 component, alpha chain; n=1; Candidatus
Protochlamydia amoebophila UWE25|Rep: Putative pyruvate
dehydrogenase (Lipoamide), E1 component, alpha chain -
Protochlamydia amoebophila (strain UWE25)
Length = 342
Score = 53.2 bits (122), Expect = 8e-06
Identities = 23/53 (43%), Positives = 32/53 (60%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVXFAHKYRADGESRSLC 712
R TG ++G+GGSMH + GG GIV QVP+ G FA KY+ + ++C
Sbjct: 106 RATGNAKGRGGSMHFFTDRLLGGFGIVTGQVPIATGAAFALKYKGNKNEVAVC 158
Score = 44.4 bits (100), Expect = 0.003
Identities = 19/60 (31%), Positives = 34/60 (56%)
Frame = +3
Query: 318 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 497
++ ++Q+ +R E + + Y++ I GF H Y GQEA+ A+ ++ T+YRCH
Sbjct: 27 IECFQQMLKIRNFELRAESAYQQGKIGGFFHAYVGQEAIQTAAVQAIGQSNWYATSYRCH 86
Score = 39.9 bits (89), Expect = 0.075
Identities = 16/42 (38%), Positives = 21/42 (50%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
V GDGA QG S N+ LW+LPC++V +G
Sbjct: 155 VAVCFMGDGAVPQGSFHESLNLASLWNLPCIYVIENNQWGMG 196
>UniRef50_Q2WB98 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex; n=1; Magnetospirillum magneticum AMB-1|Rep:
Pyruvate/2-oxoglutarate dehydrogenase complex -
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Length = 647
Score = 52.8 bits (121), Expect = 1e-05
Identities = 22/47 (46%), Positives = 30/47 (63%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVXFAHKYRADG 694
R +G RG+GGS HL G+ F+ NGI+G P+ AG+ AH+ DG
Sbjct: 89 RESGVCRGRGGSQHLRGQGFF-SNGIIGGMAPVAAGLAMAHRLAGDG 134
Score = 40.7 bits (91), Expect = 0.043
Identities = 19/59 (32%), Positives = 32/59 (54%)
Frame = +3
Query: 339 TILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCHGWTYSW 515
T++R +E +LY E + G H GQE V + +A+R D +++ +R HG +W
Sbjct: 17 TLIRVVEERLLSLYGEGRLHGTVHTCIGQEWTGVSVASALRSGDYILSNHRGHGHYLAW 75
>UniRef50_A0LTQ9 Cluster: Pyruvate dehydrogenase; n=1; Acidothermus
cellulolyticus 11B|Rep: Pyruvate dehydrogenase -
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Length = 342
Score = 52.4 bits (120), Expect = 1e-05
Identities = 29/81 (35%), Positives = 42/81 (51%)
Frame = +3
Query: 270 LDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMR 449
L + P +A + + L L+E + LR E + +L+ + +++G HL GQEAVA G
Sbjct: 9 LPERPTFTAEVNGRE-LDLFELMVRLRFFERRAHDLFLQGLVKGTSHLSLGQEAVATGFA 67
Query: 450 AAMRDADSVITAYRCHGWTYS 512
AAM D YR H T S
Sbjct: 68 AAMEPTDLTFATYRGHAHTLS 88
Score = 36.7 bits (81), Expect = 0.70
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 2/50 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVXFAHKYRADGE 697
R G GKGGSMHL G IVGA +P+ G ++ K R +
Sbjct: 103 RSVGLMAGKGGSMHLTSVEHGMMGSYAIVGAHLPVAVGAAWSAKVRGTNQ 152
>UniRef50_A7BPK6 Cluster: Pyruvate dehydrogenase; n=1; Beggiatoa sp.
PS|Rep: Pyruvate dehydrogenase - Beggiatoa sp. PS
Length = 331
Score = 52.0 bits (119), Expect = 2e-05
Identities = 24/63 (38%), Positives = 38/63 (60%)
Frame = +3
Query: 309 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAY 488
E+ L Y L ++RR+E A Y E+ +R HL GQEAVAVG+ ++ +D + +++
Sbjct: 14 EELLTFYRSLLLIRRVEEAIAERYTEQEMRCPTHLCIGQEAVAVGVCKMLQQSDGIFSSH 73
Query: 489 RCH 497
R H
Sbjct: 74 RAH 76
Score = 38.3 bits (85), Expect = 0.23
Identities = 17/38 (44%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAG 661
+ TGC G+GGSMHL F G IVG+ +P+ G
Sbjct: 96 KSTGCCGGRGGSMHLIDLAAGFIGATPIVGSTIPIAVG 133
>UniRef50_Q28MR4 Cluster: Dehydrogenase E1 component; n=8;
Bacteria|Rep: Dehydrogenase E1 component - Jannaschia
sp. (strain CCS1)
Length = 675
Score = 51.6 bits (118), Expect = 2e-05
Identities = 26/74 (35%), Positives = 40/74 (54%)
Frame = +3
Query: 285 ATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRD 464
AT L +D + + +RR ET + L+ + +I+G H GQEA+A G A +
Sbjct: 13 ATPNGLAPKDLRAALKMMLRIRRFETRAKELFLQGVIKGTAHSSVGQEAIAAGACAVLEP 72
Query: 465 ADSVITAYRCHGWT 506
AD ++T +R HG T
Sbjct: 73 ADFILTHHRGHGHT 86
Score = 44.8 bits (101), Expect = 0.003
Identities = 23/49 (46%), Positives = 27/49 (55%), Gaps = 2/49 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVXFAHKYRADG 694
R TG G GGSMH+ + R G NGIVGA + LG G A + A G
Sbjct: 103 RETGYCAGLGGSMHIADFDRGILGANGIVGAGIGLGTGAALAEQLDATG 151
Score = 38.7 bits (86), Expect = 0.17
Identities = 15/48 (31%), Positives = 27/48 (56%)
Frame = +1
Query: 649 VGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVF 792
+G+ + L Q+ + + +GDGAAN+G + N+ +W LP +F
Sbjct: 137 LGTGAALAEQLDATGAIGISFFGDGAANEGIFHEAMNLAAIWKLPLIF 184
>UniRef50_Q1ARM0 Cluster: Pyruvate dehydrogenase; n=3; Bacteria|Rep:
Pyruvate dehydrogenase - Rubrobacter xylanophilus
(strain DSM 9941 / NBRC 16129)
Length = 332
Score = 51.6 bits (118), Expect = 2e-05
Identities = 25/67 (37%), Positives = 38/67 (56%)
Frame = +3
Query: 300 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 479
L E + + + +RR E L+K + GF HLY G+EAVAVG +A+R+ D +
Sbjct: 2 LGEEKLVGMLRLMLRIRRFEEKLAELFKRGKLPGFVHLYIGEEAVAVGACSALREDDRIT 61
Query: 480 TAYRCHG 500
+ +R HG
Sbjct: 62 STHRGHG 68
Score = 39.5 bits (88), Expect = 0.099
Identities = 15/36 (41%), Positives = 22/36 (61%)
Frame = +1
Query: 688 RRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFV 795
R VT + +GDGA+NQG N+ +W LP +F+
Sbjct: 134 RDTVTVSFFGDGASNQGVFFEGMNLAAIWKLPVIFL 169
Score = 37.1 bits (82), Expect = 0.53
Identities = 17/38 (44%), Positives = 21/38 (55%), Gaps = 2/38 (5%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAG 661
+ G RGKGGSMH + G NGIVG +P+ G
Sbjct: 87 KEAGYCRGKGGSMHTVDFSLGIMGTNGIVGGGIPIAVG 124
>UniRef50_Q1KSF1 Cluster: Apicoplast pyruvate dehydrogenase E1 alpha
subunit; n=1; Toxoplasma gondii|Rep: Apicoplast pyruvate
dehydrogenase E1 alpha subunit - Toxoplasma gondii
Length = 635
Score = 51.6 bits (118), Expect = 2e-05
Identities = 21/46 (45%), Positives = 30/46 (65%), Gaps = 2/46 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVXFAHKYR 685
+ TGCSRG+GGSMH++ + N GG +G Q+P+ G F+ YR
Sbjct: 338 KATGCSRGRGGSMHMFSKKHNMIGGFAFIGEQIPVALGYAFSAAYR 383
Score = 49.2 bits (112), Expect = 1e-04
Identities = 24/58 (41%), Positives = 33/58 (56%)
Frame = +3
Query: 324 LYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 497
L E + R +E A LY GF HLY+GQEAV+ G+ +R D+V++ YR H
Sbjct: 261 LLEDMLTGRMVEDACARLYYMGKTAGFVHLYTGQEAVSAGVIKLLRPDDAVVSTYRDH 318
Score = 34.7 bits (76), Expect = 2.8
Identities = 17/42 (40%), Positives = 20/42 (47%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
V GDG N GQL + N+ L LP VFV A+G
Sbjct: 398 VAVCFLGDGTTNMGQLYEALNIAALSKLPIVFVVENNNWAIG 439
>UniRef50_Q1XDM0 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=52; cellular organisms|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Porphyra
yezoensis
Length = 346
Score = 51.6 bits (118), Expect = 2e-05
Identities = 25/71 (35%), Positives = 37/71 (52%)
Frame = +3
Query: 285 ATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRD 464
+T L + L LYE + + R E +Y + + GF HLY+GQEAV+ G+ +
Sbjct: 16 STGLNLNKSNLLVLYEDMLLGRNFEDMCAQMYYKGKMFGFVHLYNGQEAVSTGVIKLLNP 75
Query: 465 ADSVITAYRCH 497
D V + YR H
Sbjct: 76 TDYVCSTYRDH 86
Score = 46.8 bits (106), Expect = 7e-04
Identities = 19/46 (41%), Positives = 27/46 (58%), Gaps = 2/46 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVXFAHKYR 685
+ TGCS+G+GGSMH++ NF GG + +P+ G F YR
Sbjct: 106 KETGCSKGRGGSMHIFSAPHNFLGGFAFIAEGIPVATGAAFQSIYR 151
Score = 42.7 bits (96), Expect = 0.011
Identities = 18/42 (42%), Positives = 21/42 (50%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
VT +GDG N GQ NM LW LP +FV A+G
Sbjct: 163 VTACFFGDGTTNNGQFFECLNMAVLWKLPIIFVVENNQWAIG 204
>UniRef50_A0HHH5 Cluster: Dehydrogenase, E1 component; n=2;
Bacteria|Rep: Dehydrogenase, E1 component - Comamonas
testosteroni KF-1
Length = 327
Score = 50.8 bits (116), Expect = 4e-05
Identities = 26/66 (39%), Positives = 37/66 (56%)
Frame = +3
Query: 315 ALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRC 494
A +L EQ+ +R +E +L K I+G HL GQEA+ G AA + D V + YR
Sbjct: 16 AKELLEQMIRIRLLEEKIADLRKSGEIQGSVHLCIGQEAIYSGSCAARQPGDRVFSTYRG 75
Query: 495 HGWTYS 512
HGW ++
Sbjct: 76 HGWAHA 81
Score = 36.7 bits (81), Expect = 0.70
Identities = 19/49 (38%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVXFAHKYRADG 694
R TG G+GGS + F+G N IVGA P+ G A DG
Sbjct: 96 RETGVCAGRGGSAYFSAPEWGFFGENSIVGAGAPIACGAALASTMAKDG 144
>UniRef50_A4AFX0 Cluster: Acetoin dehydrogenase (TPP-dependent)
alpha chain; n=1; marine actinobacterium PHSC20C1|Rep:
Acetoin dehydrogenase (TPP-dependent) alpha chain -
marine actinobacterium PHSC20C1
Length = 327
Score = 50.4 bits (115), Expect = 5e-05
Identities = 24/63 (38%), Positives = 36/63 (57%)
Frame = +3
Query: 312 DALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYR 491
DAL+L + +R E L+ + ++RG HL GQEAV VG+ +A+ D++ YR
Sbjct: 17 DALELLRSMYEIRFFEDEIMGLFSQNLVRGSTHLCQGQEAVTVGVCSALSPGDTMTCTYR 76
Query: 492 CHG 500
HG
Sbjct: 77 GHG 79
Score = 37.1 bits (82), Expect = 0.53
Identities = 21/50 (42%), Positives = 23/50 (46%), Gaps = 2/50 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNF--YGGNGIVGAQVPLGAGVXFAHKYRADGE 697
R G GKGGSMHL + G N IVG +P G A YR E
Sbjct: 98 RAGGLCGGKGGSMHLADVSVGALGSNAIVGGHLPTTVGAALAASYRGTSE 147
Score = 36.7 bits (81), Expect = 0.70
Identities = 14/33 (42%), Positives = 20/33 (60%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFV 795
V+ A +GDG+ N G S N+ +W LP +FV
Sbjct: 148 VSVAFFGDGSTNIGAFHESLNLASIWKLPAIFV 180
>UniRef50_Q3DZ88 Cluster: Dehydrogenase, E1 component; n=1;
Chloroflexus aurantiacus J-10-fl|Rep: Dehydrogenase, E1
component - Chloroflexus aurantiacus J-10-fl
Length = 334
Score = 50.0 bits (114), Expect = 7e-05
Identities = 22/61 (36%), Positives = 35/61 (57%)
Frame = +3
Query: 333 QLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCHGWTYS 512
++ I+R E + L+ ++ G HL GQEAVA+G AAM+ D ++ +R HG +
Sbjct: 33 RMQIIRAFEEKAEELFARGLVHGTMHLSIGQEAVAIGASAAMKPGDYLLNHHRGHGHCLA 92
Query: 513 W 515
W
Sbjct: 93 W 93
Score = 43.6 bits (98), Expect = 0.006
Identities = 21/50 (42%), Positives = 28/50 (56%), Gaps = 2/50 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVXFAHKYRADGE 697
+ TG RG+GGSMH+ N G NGIVG +P+ GV + K R +
Sbjct: 107 KETGYCRGRGGSMHIANVEMNNLGANGIVGGGIPISVGVGLSIKKRRSSQ 156
Score = 41.1 bits (92), Expect = 0.033
Identities = 19/58 (32%), Positives = 28/58 (48%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTAL 819
P+ GL + R V ++GDGA N G S NM +W+LP V++ A+
Sbjct: 140 PISVGVGLSIKKRRSSQVCLTIFGDGAVNTGAFHESLNMASIWNLPVVYLCENNQYAM 197
>UniRef50_A0UXT3 Cluster: Pyruvate dehydrogenase; n=1; Clostridium
cellulolyticum H10|Rep: Pyruvate dehydrogenase -
Clostridium cellulolyticum H10
Length = 321
Score = 49.6 bits (113), Expect = 9e-05
Identities = 22/44 (50%), Positives = 27/44 (61%), Gaps = 2/44 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVXFAHK 679
R+TGC+ G+GGSMHL R +G IVG +PLG G A K
Sbjct: 86 RKTGCTSGRGGSMHLMAADRGIFGSTAIVGGSLPLGTGTALASK 129
Score = 39.1 bits (87), Expect = 0.13
Identities = 18/58 (31%), Positives = 30/58 (51%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTAL 819
P+G+ + L ++ + VT +GDGAA++G S N L LP ++V A+
Sbjct: 119 PLGTGTALASKIQKNDRVTAVFFGDGAADEGTFHESLNFASLKKLPILYVCENNFYAI 176
Score = 35.9 bits (79), Expect = 1.2
Identities = 19/66 (28%), Positives = 33/66 (50%)
Frame = +3
Query: 300 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 479
+ +E ++LY + +R +E YK ++ HL GQEA+A G+ +R D +
Sbjct: 1 MENERFIELYRVMQTIRIVERKIEEEYKNDEMKTPIHLSIGQEAIAAGVCINLRKDDYLF 60
Query: 480 TAYRCH 497
+R H
Sbjct: 61 GTHRSH 66
>UniRef50_Q3J9C5 Cluster: Dehydrogenase, E1 component; n=3;
Proteobacteria|Rep: Dehydrogenase, E1 component -
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Length = 339
Score = 49.2 bits (112), Expect = 1e-04
Identities = 30/67 (44%), Positives = 35/67 (52%), Gaps = 5/67 (7%)
Frame = +3
Query: 312 DALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG---MRAAMRDA--DSV 476
D +L ++ RR E S Y E+ + GF HLYSGQEAVA G M A R D
Sbjct: 5 DRKRLLREMVFFRRFEDRSFEAYMERKVGGFLHLYSGQEAVATGVLEMVQADRGVGFDYA 64
Query: 477 ITAYRCH 497
IT YR H
Sbjct: 65 ITGYRDH 71
Score = 48.0 bits (109), Expect = 3e-04
Identities = 22/49 (44%), Positives = 32/49 (65%), Gaps = 2/49 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVXFAHKYRADG 694
+ TG SRG+GGSMH++ + F GG +VG PL AG+ A K++ +G
Sbjct: 91 KETGSSRGRGGSMHIFDPSVRFMGGYALVGQPFPLAAGLALACKHQKEG 139
Score = 39.5 bits (88), Expect = 0.099
Identities = 17/42 (40%), Positives = 21/42 (50%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
+ GDGA NQG + NM LW LP +FV A+G
Sbjct: 141 IAVCFLGDGANNQGTFHETMNMASLWKLPVLFVCENNCYAIG 182
>UniRef50_Q1NYL5 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=1; Candidatus Sulcia muelleri str. Hc
(Homalodisca coagulata)|Rep: Pyruvate dehydrogenase E1
component alpha subunit - Candidatus Sulcia muelleri
str. Hc (Homalodisca coagulata)
Length = 58
Score = 48.8 bits (111), Expect = 2e-04
Identities = 22/54 (40%), Positives = 35/54 (64%)
Frame = +3
Query: 297 TLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAM 458
T+ ++ LK Y+ ++ R+ E +LY ++ IRGF HLY+GQEA+ G+ AM
Sbjct: 3 TINNDIYLKWYKDMSFWRKFEDKCRSLYLKQKIRGFLHLYNGQEAIPAGLVHAM 56
>UniRef50_A3CMZ3 Cluster: Pyruvate dehydrogenase, TPP-dependent E1
component alpha-subunit, putative; n=22; Bacteria|Rep:
Pyruvate dehydrogenase, TPP-dependent E1 component
alpha-subunit, putative - Streptococcus sanguinis
(strain SK36)
Length = 357
Score = 48.8 bits (111), Expect = 2e-04
Identities = 22/67 (32%), Positives = 38/67 (56%)
Frame = +3
Query: 300 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 479
++ E A +Y+ + +R E + + I GF HLY+G+EA+A G+ A + D D +
Sbjct: 39 VSKEKAKTMYKTMWDIRNFEENTRRFFAAGQIPGFVHLYAGEEAIATGVCANLTDKDYIT 98
Query: 480 TAYRCHG 500
+ +R HG
Sbjct: 99 STHRGHG 105
Score = 39.9 bits (89), Expect = 0.075
Identities = 17/52 (32%), Positives = 26/52 (50%)
Frame = +1
Query: 661 SGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTA 816
+ +R + + V +GDGAAN+G NM +W LP +FV + A
Sbjct: 162 AAMRNKYLKTDSVAVCFFGDGAANEGNFHECLNMASIWKLPVIFVNENNLFA 213
Score = 39.1 bits (87), Expect = 0.13
Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 2/45 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVXFAHKY 682
+ TG +GKGGSMH+ + G NG+VG L G +KY
Sbjct: 124 KETGLGKGKGGSMHIADLDKGILGANGMVGGGFGLATGAAMRNKY 168
>UniRef50_Q7V0M7 Cluster: Dehydrogenase, E1 component; n=1;
Prochlorococcus marinus subsp. pastoris str.
CCMP1986|Rep: Dehydrogenase, E1 component -
Prochlorococcus marinus subsp. pastoris (strain CCMP
1378 / MED4)
Length = 324
Score = 48.4 bits (110), Expect = 2e-04
Identities = 21/44 (47%), Positives = 29/44 (65%), Gaps = 2/44 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVXFAHK 679
+ +GC+ GKGGSMH+ N +G NGIVG VP+ G+ A+K
Sbjct: 111 KESGCNGGKGGSMHVADLSINHFGANGIVGGGVPIACGIALANK 154
Score = 43.2 bits (97), Expect = 0.008
Identities = 17/50 (34%), Positives = 29/50 (58%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFV 795
P+ L ++ ++ + F +GDGA+NQG +L S+N+ LP VF+
Sbjct: 144 PIACGIALANKLDKKDSIVFCFFGDGASNQGVVLESFNLAGFLSLPIVFI 193
Score = 42.3 bits (95), Expect = 0.014
Identities = 20/52 (38%), Positives = 32/52 (61%)
Frame = +3
Query: 345 LRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCHG 500
+R IE A +L K+ +RG H Y G+EA+A G+ + + D+V + +R HG
Sbjct: 41 IRAIEEAIVSLAKDNKLRGPIHSYVGEEAIATGVLSHAKPIDAVTSTHRGHG 92
>UniRef50_Q13GQ3 Cluster: Putative 2-oxo acid dehydrogenase alpha
subunit; n=1; Burkholderia xenovorans LB400|Rep:
Putative 2-oxo acid dehydrogenase alpha subunit -
Burkholderia xenovorans (strain LB400)
Length = 334
Score = 48.4 bits (110), Expect = 2e-04
Identities = 19/61 (31%), Positives = 36/61 (59%)
Frame = +3
Query: 318 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 497
+ +Y + ++R +E + L+ + + GF HL GQEAV+ G+ + + D++ T +R H
Sbjct: 20 IDIYRTMVLVREVELSLSRLFADSEVPGFIHLSLGQEAVSAGVASVLEVQDTLATTHRGH 79
Query: 498 G 500
G
Sbjct: 80 G 80
Score = 40.7 bits (91), Expect = 0.043
Identities = 19/50 (38%), Positives = 26/50 (52%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFV 795
P+ S + V + RGV A +GDGA +G L + NM LW P + V
Sbjct: 132 PIALGSAVAHHVRKTRGVAVAFFGDGAMAEGVLHETMNMAALWKAPLLLV 181
Score = 39.5 bits (88), Expect = 0.099
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Frame = +2
Query: 563 GCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVXFAHKYR 685
G +G+GGSMH+ G NGIVGA +P+ G AH R
Sbjct: 102 GLCKGRGGSMHVADLALGVLGANGIVGAGIPIALGSAVAHHVR 144
>UniRef50_A6Q3I6 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex, E1 component, alpha subunit; n=2; unclassified
Epsilonproteobacteria|Rep: Pyruvate/2-oxoglutarate
dehydrogenase complex, E1 component, alpha subunit -
Nitratiruptor sp. (strain SB155-2)
Length = 323
Score = 48.0 bits (109), Expect = 3e-04
Identities = 21/46 (45%), Positives = 29/46 (63%), Gaps = 2/46 (4%)
Frame = +2
Query: 560 TGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVXFAHKYRAD 691
TG S+GKGGSMHL+ +FYGG+ IV +P+ G +A K +
Sbjct: 87 TGISKGKGGSMHLFDPRLSFYGGDAIVAGHLPIATGCAYARKIEGE 132
Score = 44.4 bits (100), Expect = 0.003
Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 2/83 (2%)
Frame = +1
Query: 580 GRFHAFVRTQLLWWQRDCWCAG--PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRS 753
G H F +L ++ D AG P+ + ++ FA++GDGA+N G S
Sbjct: 95 GSMHLF-DPRLSFYGGDAIVAGHLPIATGCAYARKIEGENAGVFAIFGDGASNAGAFFES 153
Query: 754 YNMLKLWDLPCVFVARTTVTALG 822
N+ W LP +F A+G
Sbjct: 154 INIASAWKLPIIFFCENNYYAIG 176
Score = 36.7 bits (81), Expect = 0.70
Identities = 23/57 (40%), Positives = 28/57 (49%)
Frame = +3
Query: 327 YEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 497
Y + + R E A+ Y + I GF HL GQEA +VG A D V T YR H
Sbjct: 10 YYLMKLGREFEIAAKQEYMKGNIAGFLHLDIGQEACSVGSMQAF-DKGDVFTHYREH 65
>UniRef50_A4X7T3 Cluster: Dehydrogenase, E1 component; n=3;
Actinomycetales|Rep: Dehydrogenase, E1 component -
Salinispora tropica CNB-440
Length = 323
Score = 47.2 bits (107), Expect = 5e-04
Identities = 24/67 (35%), Positives = 37/67 (55%)
Frame = +3
Query: 300 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 479
+T +++LY + ++RR E + L + I G H Y GQE +A G+ AA+R D V
Sbjct: 1 MTEVGSVRLYRTVRLIRRFEERAIELVRSGHIVGGIHPYVGQEGIAAGVCAALRPDDVVA 60
Query: 480 TAYRCHG 500
+R HG
Sbjct: 61 GTHRGHG 67
Score = 41.1 bits (92), Expect = 0.033
Identities = 19/40 (47%), Positives = 26/40 (65%), Gaps = 3/40 (7%)
Frame = +1
Query: 685 RRRG---VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFV 795
RRRG V + GDGA N+G LL ++N+ LW +P +FV
Sbjct: 129 RRRGDDLVGVSFLGDGAVNEGMLLEAFNLAALWRVPVLFV 168
Score = 37.5 bits (83), Expect = 0.40
Identities = 20/48 (41%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVXFAHKYRAD 691
R TG +RG+GGSMH + G N IVGA + G +A + R D
Sbjct: 86 RVTGLNRGRGGSMHAADFAVGVLGANAIVGAGGAIVTGAVWARRRRGD 133
>UniRef50_Q97YF6 Cluster: Pyruvate dehydrogenase, alpha subunit
(Lipoamide); n=2; Sulfolobaceae|Rep: Pyruvate
dehydrogenase, alpha subunit (Lipoamide) - Sulfolobus
solfataricus
Length = 345
Score = 46.0 bits (104), Expect = 0.001
Identities = 29/78 (37%), Positives = 42/78 (53%), Gaps = 9/78 (11%)
Frame = +3
Query: 291 SATLTSEDALKLYEQLTILRRIETASGNLYKEKI---------IRGFCHLYSGQEAVAVG 443
+A L + D L +Y+++ I+R E + +Y E IRG HL GQEAVAVG
Sbjct: 18 NAGLKASDLLNMYKRMLIIRYFEESIRKIYHEGKNPFNMASGRIRGEMHLSIGQEAVAVG 77
Query: 444 MRAAMRDADSVITAYRCH 497
+RD D V++ +R H
Sbjct: 78 TLYDIRDEDVVVSTHRPH 95
Score = 44.8 bits (101), Expect = 0.003
Identities = 21/44 (47%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRN-FYGGNGIVGAQVPLGAGVXFAHKY 682
+ TG +GKGG MHL+ ++ + +GIVGA P AG FA KY
Sbjct: 115 KATGLCKGKGGHMHLFDKSKNFACSGIVGASFPQAAGAAFAFKY 158
>UniRef50_P27745 Cluster: Acetoin:2,6-dichlorophenolindophenol
oxidoreductase subunit alpha; n=58; cellular
organisms|Rep: Acetoin:2,6-dichlorophenolindophenol
oxidoreductase subunit alpha - Ralstonia eutropha
(strain ATCC 17699 / H16 / DSM 428 / Stanier
337)(Cupriavidus necator (strain ATCC 17699 / H16 / DSM
428 / Stanier337))
Length = 333
Score = 45.6 bits (103), Expect = 0.002
Identities = 22/50 (44%), Positives = 28/50 (56%), Gaps = 2/50 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVXFAHKYRADGE 697
++ G GKGGSMH+ + G NGI+GA PL G A K+R GE
Sbjct: 99 KKGGSCNGKGGSMHIADLSKGMMGANGILGAGAPLICGAALAAKFRGKGE 148
Score = 44.4 bits (100), Expect = 0.003
Identities = 22/67 (32%), Positives = 34/67 (50%)
Frame = +3
Query: 300 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 479
L E L +Y ++ +R E + I GF HLY+G+EA VG+ + D D +
Sbjct: 14 LDKETLLTVYRKMRTIRDFEERLHVDFGRGDIPGFVHLYAGEEAAGVGILHHLNDGDRIA 73
Query: 480 TAYRCHG 500
+ +R HG
Sbjct: 74 STHRGHG 80
Score = 42.3 bits (95), Expect = 0.014
Identities = 18/34 (52%), Positives = 24/34 (70%)
Frame = +1
Query: 694 GVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFV 795
G+TF GDGA+NQG L S N+ +W+LP +FV
Sbjct: 150 GITFC--GDGASNQGTFLESLNLAAVWNLPVIFV 181
>UniRef50_Q83X26 Cluster: Probable pyruvate dehydrogenase
alpha-subunit; n=1; Streptomyces rochei|Rep: Probable
pyruvate dehydrogenase alpha-subunit - Streptomyces
rochei (Streptomyces parvullus)
Length = 326
Score = 45.2 bits (102), Expect = 0.002
Identities = 25/60 (41%), Positives = 37/60 (61%), Gaps = 1/60 (1%)
Frame = +3
Query: 321 KLYEQLTILRRIETASGNLYK-EKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 497
+L + +R IE ++Y+ E+ +R HL GQEAVAVG+ AA+R D V + +RCH
Sbjct: 5 QLLRTMVRIRCIEEEIADVYRDEQQMRTPVHLSIGQEAVAVGVCAALRTEDVVYSGHRCH 64
Score = 33.9 bits (74), Expect = 4.9
Identities = 15/42 (35%), Positives = 23/42 (54%), Gaps = 2/42 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLY--GRNFYGGNGIVGAQVPLGAGVXFA 673
R TGC+ G+GGS+HL F + I+G + + G +A
Sbjct: 84 RETGCAAGRGGSVHLVDEAAGFGASSAILGEMISVATGAAWA 125
>UniRef50_A0LFE6 Cluster: Pyruvate dehydrogenase; n=1;
Syntrophobacter fumaroxidans MPOB|Rep: Pyruvate
dehydrogenase - Syntrophobacter fumaroxidans (strain DSM
10017 / MPOB)
Length = 320
Score = 45.2 bits (102), Expect = 0.002
Identities = 18/57 (31%), Positives = 31/57 (54%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTA 816
P+ + + +++ VT +GDGAA++G + N+ LWDLP +FV + A
Sbjct: 122 PIAAGVAFAQKYRKQKNVTVCFFGDGAADEGSFHEALNLAALWDLPVLFVCENNLYA 178
Score = 40.3 bits (90), Expect = 0.057
Identities = 23/67 (34%), Positives = 35/67 (52%), Gaps = 1/67 (1%)
Frame = +3
Query: 303 TSEDALKLYEQLTILRRIETASGNLYK-EKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 479
T E L++ + + RR E L + E + G L +GQEAVA G+ AA+ D ++
Sbjct: 4 TKEKLLEMLRSMLLTRRFEEKLTELCQIEGKVPGMMILCTGQEAVAAGVCAALEPQDVIV 63
Query: 480 TAYRCHG 500
+R HG
Sbjct: 64 PNHRSHG 70
Score = 39.1 bits (87), Expect = 0.13
Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVXFAHKYR 685
+RTG ++GK G++H+ N +VG +P+ AGV FA KYR
Sbjct: 89 KRTGFNKGKSGTLHVAVPEVNALCTTTVVGGGIPIAAGVAFAQKYR 134
>UniRef50_Q0LRY7 Cluster: Dehydrogenase, E1 component:Transketolase,
central region:Transketolase-like; n=3; cellular
organisms|Rep: Dehydrogenase, E1
component:Transketolase, central
region:Transketolase-like - Caulobacter sp. K31
Length = 680
Score = 44.8 bits (101), Expect = 0.003
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 8/88 (9%)
Frame = +3
Query: 282 PATSATLTSEDALK------LYEQLTILRRIETASGNLYKEKIIR--GFCHLYSGQEAVA 437
P T+ T EDA K ++ ++ +R E + L + R G HL +GQE V
Sbjct: 2 PGTNPRATKEDAAKAAFLSEMFGKICFVRAFEEEALRLTQANPPRVAGSMHLCAGQEVVP 61
Query: 438 VGMRAAMRDADSVITAYRCHGWTYSWAL 521
V A+ D D V+ YR HGW + L
Sbjct: 62 VAAMEALGDEDQVVCTYRGHGWALAAGL 89
>UniRef50_A6UDY5 Cluster: Dehydrogenase E1 component; n=2;
Alphaproteobacteria|Rep: Dehydrogenase E1 component -
Sinorhizobium medicae WSM419
Length = 342
Score = 44.4 bits (100), Expect = 0.003
Identities = 21/54 (38%), Positives = 30/54 (55%)
Frame = +1
Query: 661 SGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTALG 822
+GL + ++ V+ A +GDGA QG L S NM LW+LP +FV +G
Sbjct: 128 AGLSSRHLKQDSVSIAFFGDGAMQQGILYESMNMASLWNLPVLFVCINNQYGMG 181
Score = 37.9 bits (84), Expect = 0.30
Identities = 22/62 (35%), Positives = 32/62 (51%), Gaps = 1/62 (1%)
Frame = +3
Query: 318 LKLYEQLTILRRIETASGNLYKEKIIRG-FCHLYSGQEAVAVGMRAAMRDADSVITAYRC 494
L+LY + +R E G L+ G HL G+E+ A G+ AAM+ D+ T +R
Sbjct: 10 LELYRTMRRIRTFEERVGELFVRGQSAGSMLHLSIGEESSAAGVCAAMKPQDTFTTHHRG 69
Query: 495 HG 500
HG
Sbjct: 70 HG 71
Score = 37.5 bits (83), Expect = 0.40
Identities = 20/45 (44%), Positives = 25/45 (55%), Gaps = 4/45 (8%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVP--LGAGVXFAH 676
+ TG RGKGGSMH+ G N IVG +P +GAG+ H
Sbjct: 90 KETGYCRGKGGSMHIADMALGHLGANAIVGGGIPAVIGAGLSSRH 134
>UniRef50_Q8YDG0 Cluster: 2-OXOISOVALERATE DEHYDROGENASE BETA
SUBUNIT; n=3; Brucella|Rep: 2-OXOISOVALERATE
DEHYDROGENASE BETA SUBUNIT - Brucella melitensis
Length = 725
Score = 44.0 bits (99), Expect = 0.005
Identities = 21/62 (33%), Positives = 32/62 (51%)
Frame = +3
Query: 312 DALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYR 491
D LK Y Q+ ++RR E + K ++ G H GQEA AVG + ++ D + +R
Sbjct: 30 DLLKWYSQMKLIRRFEEKILDFEKAGLVHGPAHASIGQEAAAVGAMSVLKTDDQINGTHR 89
Query: 492 CH 497
H
Sbjct: 90 TH 91
Score = 36.7 bits (81), Expect = 0.70
Identities = 16/58 (27%), Positives = 30/58 (51%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTAL 819
P + L ++ R+G++ A +GDG + QG + N+ L+ LP +F + A+
Sbjct: 165 PHAAGYALADKILNRKGISVAFFGDGPSLQGATYEAMNIAALYRLPVIFYVENNLYAV 222
>UniRef50_A5V557 Cluster: Pyruvate dehydrogenase; n=1; Sphingomonas
wittichii RW1|Rep: Pyruvate dehydrogenase - Sphingomonas
wittichii RW1
Length = 331
Score = 43.6 bits (98), Expect = 0.006
Identities = 20/65 (30%), Positives = 37/65 (56%)
Frame = +3
Query: 306 SEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITA 485
++ +L+ Y ++ +R+ E + ++ + I G H Y+GQEA VG A+ D D ++
Sbjct: 6 NDRSLEKYRRMQRIRQFEDLAEAIHAQGEIPGSLHTYAGQEASGVGACMALDDTDYMVGT 65
Query: 486 YRCHG 500
+R HG
Sbjct: 66 HRSHG 70
Score = 40.3 bits (90), Expect = 0.057
Identities = 22/55 (40%), Positives = 30/55 (54%), Gaps = 2/55 (3%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVXFAHKYRADGESRSLC 712
+ TG +GKGGSMHL + G IVG+ VP+ AG K + +G +LC
Sbjct: 89 KATGICKGKGGSMHLSDFSVGSLGETSIVGSGVPVAAGAALGSKLQGNGRV-ALC 142
Score = 38.3 bits (85), Expect = 0.23
Identities = 16/50 (32%), Positives = 25/50 (50%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFV 795
PV + + L ++ V +GDGA N+G N+ +W LP +FV
Sbjct: 122 PVAAGAALGSKLQGNGRVALCFFGDGATNEGAFHEGMNLAAVWALPAIFV 171
>UniRef50_A5U0N1 Cluster: Dehydrogenase E1 component; n=7;
Mycobacterium tuberculosis complex|Rep: Dehydrogenase E1
component - Mycobacterium tuberculosis (strain ATCC
25177 / H37Ra)
Length = 334
Score = 43.2 bits (97), Expect = 0.008
Identities = 23/59 (38%), Positives = 35/59 (59%)
Frame = +3
Query: 321 KLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 497
+LY ++ +LR ++ A L E +I G GQEAV+VG AA+ + D +IT +R H
Sbjct: 18 ELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGEGDVIITTHRPH 76
>UniRef50_A4VXG8 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex, dehydrogenase (E1) component, eukaryotic type,
alpha subunit; n=40; Streptococcus|Rep:
Pyruvate/2-oxoglutarate dehydrogenase complex,
dehydrogenase (E1) component, eukaryotic type, alpha
subunit - Streptococcus suis (strain 05ZYH33)
Length = 337
Score = 43.2 bits (97), Expect = 0.008
Identities = 19/68 (27%), Positives = 36/68 (52%)
Frame = +3
Query: 297 TLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSV 476
++T E L ++ ++ +R ++ L + ++G H G+EA AVG A + D D +
Sbjct: 18 SITKEQHLDMFLKMQQIRDVDMKLNKLVRRGFVQGMTHFSVGEEAAAVGPIAGLTDEDII 77
Query: 477 ITAYRCHG 500
+ +R HG
Sbjct: 78 FSHHRGHG 85
Score = 40.3 bits (90), Expect = 0.057
Identities = 19/45 (42%), Positives = 25/45 (55%), Gaps = 2/45 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVXFAHKY 682
+ TG S+G+GGSMHL + +G NGIVG L G +Y
Sbjct: 104 KATGTSKGRGGSMHLANVEKGNFGSNGIVGGGYALAVGAALTQQY 148
Score = 33.5 bits (73), Expect = 6.5
Identities = 12/32 (37%), Positives = 18/32 (56%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLPCVF 792
+ A GD A N+G S N+ +W+LP +F
Sbjct: 154 IVIAFSGDSATNEGSFHESMNLAAVWNLPVIF 185
>UniRef50_Q2BFQ9 Cluster: Putative uncharacterized protein; n=1;
Bacillus sp. NRRL B-14911|Rep: Putative uncharacterized
protein - Bacillus sp. NRRL B-14911
Length = 668
Score = 42.7 bits (96), Expect = 0.011
Identities = 21/67 (31%), Positives = 37/67 (55%)
Frame = +3
Query: 300 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 479
L+ E +Y+++ +R +E +L+ + + G H GQEA AV A +++ D V
Sbjct: 14 LSQETIDSMYKKMITIRTLEETLLDLFSKGELFGTTHTSIGQEANAVASMAHIKNGDVVF 73
Query: 480 TAYRCHG 500
+ +RCHG
Sbjct: 74 SNHRCHG 80
Score = 33.9 bits (74), Expect = 4.9
Identities = 21/68 (30%), Positives = 32/68 (47%), Gaps = 8/68 (11%)
Frame = +1
Query: 643 GPVGSWSG--LRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFV------A 798
G VG+ +G L ++ + GDG +G + S N LWD+P +F+ A
Sbjct: 126 GIVGNATGAALANKLTGTDNIAVVFIGDGTLGEGLVYESMNFASLWDIPILFILENNRYA 185
Query: 799 RTTVTALG 822
+TT LG
Sbjct: 186 QTTPNELG 193
>UniRef50_Q00TN9 Cluster: Pyruvate dehydrogenase E1 component beta;
n=3; Ostreococcus|Rep: Pyruvate dehydrogenase E1
component beta - Ostreococcus tauri
Length = 835
Score = 42.7 bits (96), Expect = 0.011
Identities = 23/66 (34%), Positives = 32/66 (48%)
Frame = +3
Query: 300 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 479
L+ ED K Y + + R E Y IRGF HL +GQE++ + A+R D
Sbjct: 132 LSDEDLSKAYYMMQLCRDFENECNQAYMAGKIRGFMHLDNGQESIPALLNDAIRKDDLKH 191
Query: 480 TAYRCH 497
+ YR H
Sbjct: 192 SYYRDH 197
Score = 35.5 bits (78), Expect = 1.6
Identities = 17/35 (48%), Positives = 20/35 (57%), Gaps = 2/35 (5%)
Frame = +2
Query: 563 GCSRGKGGSMHLY--GRNFYGGNGIVGAQVPLGAG 661
G RG GGSMH+Y NF GG +V Q+P G
Sbjct: 220 GTCRGTGGSMHVYDMDTNFQGGWALVAEQLPYAVG 254
>UniRef50_A5V4J0 Cluster: Pyruvate dehydrogenase; n=2; Sphingomonas
wittichii RW1|Rep: Pyruvate dehydrogenase - Sphingomonas
wittichii RW1
Length = 327
Score = 42.3 bits (95), Expect = 0.014
Identities = 19/40 (47%), Positives = 24/40 (60%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTA 816
VT A +GDGAAN G + + NM LW LP +FV + A
Sbjct: 142 VTIANFGDGAANIGAVHEAMNMAALWQLPVIFVCQNNAYA 181
Score = 35.9 bits (79), Expect = 1.2
Identities = 19/49 (38%), Positives = 25/49 (51%), Gaps = 2/49 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLY--GRNFYGGNGIVGAQVPLGAGVXFAHKYRADG 694
R TG +GKGG MHL + GIVG+ P+ G+ +A K G
Sbjct: 92 RVTGACKGKGGPMHLTYPAKGIMVTTGIVGSTAPIANGLAWAAKLEGKG 140
>UniRef50_A3SJ75 Cluster: 2-oxoisovalerate dehydrogenase beta
subunit; n=1; Roseovarius nubinhibens ISM|Rep:
2-oxoisovalerate dehydrogenase beta subunit -
Roseovarius nubinhibens ISM
Length = 746
Score = 42.3 bits (95), Expect = 0.014
Identities = 20/59 (33%), Positives = 31/59 (52%)
Frame = +3
Query: 321 KLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 497
++ EQL ++R E L KE ++ G H GQE AVG+ +A+ D + +R H
Sbjct: 47 RMLEQLFLIRHFEERLLELSKEGLLHGPAHASIGQEGAAVGLMSALTSGDKINGTHRMH 105
Score = 34.7 bits (76), Expect = 2.8
Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 2/47 (4%)
Frame = +2
Query: 557 RTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVXFAHKYRAD 691
++G G+GGSMHL G N IVG +P G A K R +
Sbjct: 147 KSGYCGGRGGSMHLREPEAGVLGSNAIVGGNIPHAVGYALADKMRGE 193
>UniRef50_A0JUQ5 Cluster: Pyruvate dehydrogenase; n=4;
Actinobacteria (class)|Rep: Pyruvate dehydrogenase -
Arthrobacter sp. (strain FB24)
Length = 392
Score = 42.3 bits (95), Expect = 0.014
Identities = 23/70 (32%), Positives = 39/70 (55%)
Frame = +3
Query: 300 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 479
++ E LYE + ++RRI+T + L ++ + G GQEA +G ++RD D V
Sbjct: 53 VSDEQLGSLYEDMVVIRRIDTEATALQRQGEL-GLWPPLLGQEASQIGSARSLRDDDFVF 111
Query: 480 TAYRCHGWTY 509
++YR +G Y
Sbjct: 112 SSYRENGVAY 121
>UniRef50_Q319T4 Cluster: Pyruvate dehydrogenase; n=1;
Prochlorococcus marinus str. MIT 9312|Rep: Pyruvate
dehydrogenase - Prochlorococcus marinus (strain MIT
9312)
Length = 347
Score = 41.9 bits (94), Expect = 0.019
Identities = 21/48 (43%), Positives = 28/48 (58%), Gaps = 2/48 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVXFAHKYRAD 691
+ +G S+G GGSMHL+G + F G IVG VPL G A K + +
Sbjct: 108 KSSGISKGMGGSMHLFGGSVGFCGSVPIVGGTVPLAVGTALASKLKEE 155
Score = 35.1 bits (77), Expect = 2.1
Identities = 17/63 (26%), Positives = 33/63 (52%)
Frame = +3
Query: 309 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAY 488
++ L++ ++ ++R E + ++ G HL GQEA+ VG+ + + D V A+
Sbjct: 26 DELLEMLSKMILIRNAEYKIAKGREFGLVGGPVHLGVGQEAIPVGISQYLNNQDKVFGAH 85
Query: 489 RCH 497
R H
Sbjct: 86 RSH 88
>UniRef50_Q98FT3 Cluster: Acetoin dehydrogenase (TPP-dependent)
alpha chain; n=6; Bacteria|Rep: Acetoin dehydrogenase
(TPP-dependent) alpha chain - Rhizobium loti
(Mesorhizobium loti)
Length = 342
Score = 41.1 bits (92), Expect = 0.033
Identities = 19/66 (28%), Positives = 36/66 (54%)
Frame = +3
Query: 303 TSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVIT 482
++E ++ ++ ++RR E + Y +I G HL GQEA A+G+ + + D + +
Sbjct: 23 SAEQLREVLYKMYLIRRFEEGAEESYMRGLIHGTMHLSIGQEASAMGICMPLGEDDQITS 82
Query: 483 AYRCHG 500
+R HG
Sbjct: 83 THRGHG 88
Score = 39.9 bits (89), Expect = 0.075
Identities = 18/50 (36%), Positives = 27/50 (54%), Gaps = 2/50 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVXFAHKYRADGE 697
+ TG +G+GGSMH+ + G NGIVG +P+ G + K G+
Sbjct: 107 KTTGYCKGRGGSMHIADVAKGNLGANGIVGGGIPIAVGAALSSKMMKTGK 156
Score = 38.7 bits (86), Expect = 0.17
Identities = 16/50 (32%), Positives = 27/50 (54%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFV 795
P+ + L ++ + V + +GDGA N+G + NM +W LP +FV
Sbjct: 140 PIAVGAALSSKMMKTGKVVVSFFGDGANNEGAFHEALNMAAVWKLPVIFV 189
>UniRef50_Q7N3C2 Cluster: Similar to 3-methyl-2-oxobutanoate
dehydrogenase; n=1; Photorhabdus luminescens subsp.
laumondii|Rep: Similar to 3-methyl-2-oxobutanoate
dehydrogenase - Photorhabdus luminescens subsp.
laumondii
Length = 650
Score = 41.1 bits (92), Expect = 0.033
Identities = 20/46 (43%), Positives = 25/46 (54%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVXFAHKYRAD 691
+ TG G+GGS HL F+ NGI G +P+ G FA K R D
Sbjct: 82 KETGVCGGRGGSQHLCKEGFF-SNGIQGGILPVATGAAFAKKLRHD 126
>UniRef50_Q8YDW3 Cluster: 2-OXOISOVALERATE DEHYDROGENASE BETA
SUBUNIT; n=10; Bacteria|Rep: 2-OXOISOVALERATE
DEHYDROGENASE BETA SUBUNIT - Brucella melitensis
Length = 729
Score = 40.7 bits (91), Expect = 0.043
Identities = 21/47 (44%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Frame = +2
Query: 563 GCSRGKGGSMHLYGRNF--YGGNGIVGAQVPLGAGVXFAHKYRADGE 697
G RG+GGSMHL G N IVG VP+ AG +AH+ G+
Sbjct: 134 GFCRGRGGSMHLRWAESGNLGTNAIVGGGVPMAAGAAWAHRRAGKGD 180
Score = 35.1 bits (77), Expect = 2.1
Identities = 14/34 (41%), Positives = 20/34 (58%), Gaps = 1/34 (2%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLP-CVFV 795
V + +GDGA N G +L + N+ W LP C F+
Sbjct: 181 VVYTYFGDGATNIGSVLETMNLAAAWKLPICFFI 214
Score = 34.7 bits (76), Expect = 2.8
Identities = 17/58 (29%), Positives = 29/58 (50%)
Frame = +3
Query: 324 LYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 497
+ Q+ ++R E L + ++ G H GQE AVG +MR +D + ++R H
Sbjct: 34 MLSQMHLIRAFEEKVLELAGQGLVHGPAHSAIGQEGGAVGSAVSMRPSDQINGSHRAH 91
>UniRef50_Q479Q2 Cluster: Dehydrogenase, E1 component; n=2;
Rhodocyclaceae|Rep: Dehydrogenase, E1 component -
Dechloromonas aromatica (strain RCB)
Length = 320
Score = 40.7 bits (91), Expect = 0.043
Identities = 26/66 (39%), Positives = 35/66 (53%)
Frame = +3
Query: 303 TSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVIT 482
T+ D L+LYEQL ++R E A + I G C GQEA AVG A+ D ++T
Sbjct: 6 TAVDPLRLYEQLLLIRAYENAIVRGSTDGRIPGTC-TSVGQEAAAVGAINALEADDLILT 64
Query: 483 AYRCHG 500
+R G
Sbjct: 65 NHRSAG 70
Score = 37.5 bits (83), Expect = 0.40
Identities = 14/36 (38%), Positives = 22/36 (61%)
Frame = +1
Query: 688 RRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFV 795
R G+ +GDGAA +G S N+ LW+LP +++
Sbjct: 136 RPGIVACFFGDGAACEGSFHESLNLAALWNLPVLYI 171
>UniRef50_Q53610 Cluster: Branched-chain alpha-keto acid
dehydrogenase E1-alpha subunit; n=16;
Actinomycetales|Rep: Branched-chain alpha-keto acid
dehydrogenase E1-alpha subunit - Streptomyces
avermitilis
Length = 406
Score = 40.3 bits (90), Expect = 0.057
Identities = 23/69 (33%), Positives = 34/69 (49%)
Frame = +3
Query: 294 ATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADS 473
A +T E+ LY + + RR + + +L ++ + G GQEA +G A RD D
Sbjct: 63 ADITPEELRGLYRDMVLSRRFDAEATSLQRQGEL-GLWASMLGQEAAQIGSGRATRDDDY 121
Query: 474 VITAYRCHG 500
V YR HG
Sbjct: 122 VFPTYREHG 130
>UniRef50_Q0ET31 Cluster: Dehydrogenase, E1 component; n=1;
Thermoanaerobacter ethanolicus X514|Rep: Dehydrogenase,
E1 component - Thermoanaerobacter ethanolicus X514
Length = 262
Score = 40.3 bits (90), Expect = 0.057
Identities = 19/45 (42%), Positives = 25/45 (55%), Gaps = 1/45 (2%)
Frame = +2
Query: 560 TGCSRGKGGSMHLYGRN-FYGGNGIVGAQVPLGAGVXFAHKYRAD 691
TG RGKGG MHL+ + + +GIVGA +P G K R +
Sbjct: 100 TGLGRGKGGHMHLFDPDVHFSCSGIVGASIPQAVGAALTFKMRKE 144
>UniRef50_Q3WCG3 Cluster: Pyruvate dehydrogenase; n=4;
Actinomycetales|Rep: Pyruvate dehydrogenase - Frankia
sp. EAN1pec
Length = 332
Score = 39.9 bits (89), Expect = 0.075
Identities = 20/42 (47%), Positives = 24/42 (57%), Gaps = 3/42 (7%)
Frame = +1
Query: 685 RRRG---VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVAR 801
RR+G VT +GDGA N G + NM LWDLP V V +
Sbjct: 137 RRKGLDRVTAVSFGDGATNTGSFHEAANMAALWDLPLVLVCQ 178
>UniRef50_A7HBV0 Cluster: 3-methyl-2-oxobutanoate dehydrogenase;
n=4; Cystobacterineae|Rep: 3-methyl-2-oxobutanoate
dehydrogenase - Anaeromyxobacter sp. Fw109-5
Length = 399
Score = 39.9 bits (89), Expect = 0.075
Identities = 32/107 (29%), Positives = 48/107 (44%), Gaps = 2/107 (1%)
Frame = +3
Query: 279 GPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAM 458
G TL + L+LY + + R ++ L ++ I GF G+EA +G AAM
Sbjct: 44 GAPDEVTLPDAEVLRLYRLMVLNRSLDERMITLQRQGRI-GFYIGSIGEEATILGSAAAM 102
Query: 459 RDADSVITAYRCHGWTY--SWALVCWGCSRS*RGAGPVAPGAREVPC 593
++D + YR HG LV + C AG G R++PC
Sbjct: 103 AESDWIFPCYREHGAALMRGMPLVTFLCDLF-GNAGDAMKG-RQMPC 147
>UniRef50_A6WG12 Cluster: Pyruvate dehydrogenase; n=3;
Actinomycetales|Rep: Pyruvate dehydrogenase -
Kineococcus radiotolerans SRS30216
Length = 390
Score = 39.9 bits (89), Expect = 0.075
Identities = 25/73 (34%), Positives = 33/73 (45%)
Frame = +3
Query: 282 PATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMR 461
P L E+ L L + +LRR++ A G + + G GQEA VG A R
Sbjct: 36 PEHEVDLEPEELLALLRDMVLLRRLD-AEGEALQRQGQLGLWPGSRGQEAAQVGSATACR 94
Query: 462 DADSVITAYRCHG 500
D V +YR HG
Sbjct: 95 RQDQVFPSYRDHG 107
>UniRef50_Q0RLC2 Cluster: Pyruvate dehydrogenase E1 component, alpha
subunit; n=2; Bacteria|Rep: Pyruvate dehydrogenase E1
component, alpha subunit - Frankia alni (strain ACN14a)
Length = 342
Score = 39.1 bits (87), Expect = 0.13
Identities = 18/52 (34%), Positives = 27/52 (51%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVAR 801
P+ + L Q+ VT +GDGA+N G S N+ +W LP +FV +
Sbjct: 137 PIANGLALSAQLRGTDQVTVVNFGDGASNIGAFHESLNLASIWRLPVIFVCQ 188
>UniRef50_A0H3S4 Cluster: Putative uncharacterized protein; n=1;
Chloroflexus aggregans DSM 9485|Rep: Putative
uncharacterized protein - Chloroflexus aggregans DSM
9485
Length = 400
Score = 39.1 bits (87), Expect = 0.13
Identities = 25/83 (30%), Positives = 37/83 (44%), Gaps = 1/83 (1%)
Frame = -2
Query: 726 GSVSVQSERDSPSARYLWAKXTPAPNGTCAPTIPLPP*KLRPYKCMEPPLPREQPVLRPV 547
G+V +R P+ W+ P P G A PP + RP P L R QPV
Sbjct: 176 GAVRWSDDRPLPTGAVRWSDDRPLPTGAVAQPSASPPARCRPVPWRSPALHR-QPVADRC 234
Query: 546 SSESTPSTLTPM-SKSIRDNDTR 481
+ ST +P+ + ++R +D R
Sbjct: 235 RGAAQRSTASPLPTGAVRWSDDR 257
>UniRef50_Q11G20 Cluster: Twin-arginine translocation pathway
signal; n=2; Proteobacteria|Rep: Twin-arginine
translocation pathway signal - Mesorhizobium sp. (strain
BNC1)
Length = 375
Score = 38.7 bits (86), Expect = 0.17
Identities = 21/59 (35%), Positives = 35/59 (59%), Gaps = 4/59 (6%)
Frame = +3
Query: 321 KLYEQLTILRRIE----TASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITA 485
+L + T + RI T + + + RG+ H Y+GQEAVAVG+ +A+R++ V+ A
Sbjct: 30 QLVDMFTTILRIRWHERTMADKMLTDPNYRGYNHFYAGQEAVAVGVCSALRNSGGVMHA 88
>UniRef50_Q9HN77 Cluster: Pyruvate dehydrogenase alpha subunit; n=8;
Halobacteriaceae|Rep: Pyruvate dehydrogenase alpha
subunit - Halobacterium salinarium (Halobacterium
halobium)
Length = 419
Score = 38.3 bits (85), Expect = 0.23
Identities = 19/67 (28%), Positives = 37/67 (55%)
Frame = +3
Query: 300 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 479
LT ++ +++Y + + RR + + +L ++ I + L SGQE + A+ D D ++
Sbjct: 79 LTDDELVEMYRYMKLARRFDERAVSLQRQGRIGTYPPL-SGQEGAQIASAMALADDDWIV 137
Query: 480 TAYRCHG 500
+YR HG
Sbjct: 138 PSYREHG 144
>UniRef50_Q9NYV4 Cluster: Cell division cycle 2-related protein
kinase 7; n=32; Euteleostomi|Rep: Cell division cycle
2-related protein kinase 7 - Homo sapiens (Human)
Length = 1490
Score = 37.9 bits (84), Expect = 0.30
Identities = 28/71 (39%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Frame = -2
Query: 708 SERDSPSARYLWAKXTPA-PNGTCAP-TIPLPP*KLRPYKCMEPPLPREQPVLRPVSSES 535
SE+++P A P P T P T PLPP P +PPLP QP V + S
Sbjct: 521 SEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASS 580
Query: 534 TPSTLTPMSKS 502
T STL P + S
Sbjct: 581 T-STLPPSTHS 590
>UniRef50_Q18CB6 Cluster: Acetoin:2,6-dichlorophenolindophenol
oxidoreductase alpha subunit; n=2; Clostridium
difficile|Rep: Acetoin:2,6-dichlorophenolindophenol
oxidoreductase alpha subunit - Clostridium difficile
(strain 630)
Length = 322
Score = 37.5 bits (83), Expect = 0.40
Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 2/50 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVXFAHKYRADGE 697
+ TG +GKGGSMH+ G NG+VG + + G +Y+ G+
Sbjct: 90 KETGFCKGKGGSMHIADIESGNLGANGVVGGGLTIAPGAALTQQYKKTGK 139
Score = 34.7 bits (76), Expect = 2.8
Identities = 13/44 (29%), Positives = 22/44 (50%)
Frame = +1
Query: 661 SGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVF 792
+ L Q + + +GDGA+N+G N+ +W LP +F
Sbjct: 128 AALTQQYKKTGKIVLCSFGDGASNEGTFHEGINLSSIWKLPIIF 171
>UniRef50_Q0RVK8 Cluster: Probable pyruvate dehydrogenase; n=1;
Rhodococcus sp. RHA1|Rep: Probable pyruvate
dehydrogenase - Rhodococcus sp. (strain RHA1)
Length = 344
Score = 37.5 bits (83), Expect = 0.40
Identities = 18/46 (39%), Positives = 26/46 (56%), Gaps = 2/46 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHL-YG-RNFYGGNGIVGAQVPLGAGVXFAHKYR 685
R T SRG+ G H+ Y YG G++GA +P+ AGV + + R
Sbjct: 109 RATAPSRGRAGETHINYAPARIYGTTGVLGANIPIAAGVAYGVQQR 154
Score = 36.3 bits (80), Expect = 0.93
Identities = 12/35 (34%), Positives = 21/35 (60%)
Frame = +1
Query: 712 YGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTA 816
+G+G +N+G + NM +WDLP +F+ + A
Sbjct: 164 FGEGTSNRGAFHEALNMAAIWDLPVIFICENNLYA 198
>UniRef50_Q0MX87 Cluster: Acetoin dehydrogenase alpha-subunit; n=2;
Bacteria|Rep: Acetoin dehydrogenase alpha-subunit -
consortium cosmid clone pGZ1
Length = 344
Score = 37.5 bits (83), Expect = 0.40
Identities = 21/56 (37%), Positives = 30/56 (53%), Gaps = 3/56 (5%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVXFAHKYRADG-ESRSLC 712
R +G GKGGSMH+ + G NG+V A +P+ G A R G +S ++C
Sbjct: 106 RASGFCGGKGGSMHIADFSVGMLGANGVVAAGIPIAVGA--AQSMRVQGRDSIAVC 159
Score = 36.3 bits (80), Expect = 0.93
Identities = 17/38 (44%), Positives = 25/38 (65%)
Frame = +3
Query: 393 IRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCHGWT 506
+RG HL +GQEAVA G+ + +R D + + +R HG T
Sbjct: 52 VRGPLHLSTGQEAVATGVCSQLRADDWLTSTHRGHGHT 89
>UniRef50_Q41071 Cluster: Arabinogalactan-like protein; n=2;
Pinaceae|Rep: Arabinogalactan-like protein - Pinus taeda
(Loblolly pine)
Length = 168
Score = 37.5 bits (83), Expect = 0.40
Identities = 28/79 (35%), Positives = 33/79 (41%), Gaps = 3/79 (3%)
Frame = -2
Query: 741 LTLVGGSVSVQSERDSPSARYLWAKXTPAPNGTCAPTIPLPP*KLR---PYKCMEPPLPR 571
L L+ G + V S SPSA + TPAP T APT P + P PP+
Sbjct: 11 LFLLAGFL-VSSMAQSPSASPTKSPTTPAPTTTAAPTTTAAPPTITATPPTTTATPPVST 69
Query: 570 EQPVLRPVSSESTPSTLTP 514
PV P S P TP
Sbjct: 70 PPPVSSPPPVTSPPPAATP 88
>UniRef50_A1SN84 Cluster: Pyruvate dehydrogenase; n=12;
Bacteria|Rep: Pyruvate dehydrogenase - Nocardioides sp.
(strain BAA-499 / JS614)
Length = 344
Score = 37.1 bits (82), Expect = 0.53
Identities = 16/33 (48%), Positives = 20/33 (60%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFV 795
+ A+ G+GAANQG S N+ W LP VFV
Sbjct: 165 IAVAVTGEGAANQGAFHESLNLAARWSLPVVFV 197
>UniRef50_Q5VST9 Cluster: Obscurin; n=50; Amniota|Rep: Obscurin - Homo
sapiens (Human)
Length = 7968
Score = 37.1 bits (82), Expect = 0.53
Identities = 29/93 (31%), Positives = 36/93 (38%), Gaps = 10/93 (10%)
Frame = -2
Query: 762 HVVASKKLTLVGGSV-SVQSERDSPS------ARYLWAKXTPAPNGTCAP---TIPLPP* 613
H SK+L GG + Q ER SP A + K AP C+P P PP
Sbjct: 7000 HPQGSKQLPSTGGHPGTAQPERPSPDSPWGQPAPFCHPKQGSAPQEGCSPHPAVAPCPPG 7059
Query: 612 KLRPYKCMEPPLPREQPVLRPVSSESTPSTLTP 514
P C E PL P L + P+ +P
Sbjct: 7060 SFPPGSCKEAPLVPSSPFLGQPQAPPAPAKASP 7092
>UniRef50_Q748I3 Cluster: Dehydrogenase, E1 component, alpha and
beta subunits; n=1; Geobacter sulfurreducens|Rep:
Dehydrogenase, E1 component, alpha and beta subunits -
Geobacter sulfurreducens
Length = 652
Score = 36.7 bits (81), Expect = 0.70
Identities = 18/64 (28%), Positives = 32/64 (50%)
Frame = +3
Query: 309 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAY 488
+D +L +R++E L+ E ++ G H GQE V + A++ D+V + +
Sbjct: 11 KDCYELTVTALTIRKVEERLLELFSEGVLNGTIHTCIGQEWTGVAVANALQAGDTVFSNH 70
Query: 489 RCHG 500
R HG
Sbjct: 71 RGHG 74
Score = 36.7 bits (81), Expect = 0.70
Identities = 18/38 (47%), Positives = 22/38 (57%)
Frame = +2
Query: 563 GCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVXFAH 676
G G GGS HL+ NF+ NGI G VP+ AG A+
Sbjct: 96 GVCGGVGGSQHLHTENFF-SNGIQGGMVPVAAGRALAN 132
>UniRef50_Q8D6Q7 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex, dehydrogenase component, eukaryotic type, alpha
subunit; n=4; Vibrionaceae|Rep: Pyruvate/2-oxoglutarate
dehydrogenase complex, dehydrogenase component,
eukaryotic type, alpha subunit - Vibrio vulnificus
Length = 364
Score = 36.3 bits (80), Expect = 0.93
Identities = 21/61 (34%), Positives = 26/61 (42%)
Frame = +1
Query: 637 CAGPVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTA 816
C VG S L+ Q GDGA ++G L S N +W LP VFV A
Sbjct: 138 CTHAVGVASALKIQ--GNHDAALVTCGDGATSKGDFLESINCAGVWHLPLVFVVNNNQWA 195
Query: 817 L 819
+
Sbjct: 196 I 196
>UniRef50_A6CP23 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
alpha subunit; n=2; Bacillus sp. SG-1|Rep: Pyruvate
dehydrogenase E1 (Lipoamide) alpha subunit - Bacillus
sp. SG-1
Length = 364
Score = 36.3 bits (80), Expect = 0.93
Identities = 24/100 (24%), Positives = 47/100 (47%), Gaps = 5/100 (5%)
Frame = +3
Query: 216 IQHEKRGDIRNQAYKLHKLDQGPAT-----SATLTSEDALKLYEQLTILRRIETASGNLY 380
IQ RG+ + + + ++ T +T + A + Y + +R + + +L
Sbjct: 2 IQSRDRGEEMEEQFPIKRIIDNDGTLLGDKDPGITEQLAKEFYRHMVRIRTFDKKAISLQ 61
Query: 381 KEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCHG 500
++ I + + GQEA VG AA+++ D + +YR HG
Sbjct: 62 RQGRIGTYAP-FEGQEASQVGSSAALKEDDWMFPSYRDHG 100
>UniRef50_Q6A611 Cluster: Pyruvate dehydrogenase E1 component, alpha
subunit; n=1; Propionibacterium acnes|Rep: Pyruvate
dehydrogenase E1 component, alpha subunit -
Propionibacterium acnes
Length = 381
Score = 35.9 bits (79), Expect = 1.2
Identities = 22/82 (26%), Positives = 36/82 (43%)
Frame = +3
Query: 267 KLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGM 446
+L P L +D +K E + + RR++ + L + + G GQEA G
Sbjct: 40 RLTTHPDFPVDLVDDDLVKALEMMVMTRRLDVEATALQRHGEL-GLWPPLLGQEATQAGA 98
Query: 447 RAAMRDADSVITAYRCHGWTYS 512
A+R+ D V YR G ++
Sbjct: 99 WLALREGDQVFPTYREQGLAHA 120
>UniRef50_Q49108 Cluster: Pyruvate dehydrogenase EI alpha subunit;
n=5; Mollicutes|Rep: Pyruvate dehydrogenase EI alpha
subunit - Mycoplasma capricolum
Length = 370
Score = 35.9 bits (79), Expect = 1.2
Identities = 14/42 (33%), Positives = 23/42 (54%)
Frame = +1
Query: 694 GVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTAL 819
GV GDG +++G+ + N KL ++PC+FV A+
Sbjct: 158 GVVVTTTGDGGSSEGETYEAMNFAKLHEVPCIFVIENNKWAI 199
>UniRef50_Q1LFS5 Cluster: Dehydrogenase, E1 component; n=22;
Proteobacteria|Rep: Dehydrogenase, E1 component -
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM
2839)
Length = 367
Score = 35.9 bits (79), Expect = 1.2
Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 6/78 (7%)
Frame = +3
Query: 318 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 497
L LY + + R+ + + + + I F GQEA+ VG+ AMR D ++ +YR H
Sbjct: 36 LPLYRAMVLTRQFDLKAIAMQRTGQIGTFASAL-GQEAIGVGVATAMRRDDVLVPSYRDH 94
Query: 498 ------GWTYSWALVCWG 533
G T + +L+ WG
Sbjct: 95 AAQFVRGVTMTESLLYWG 112
>UniRef50_A4XHV5 Cluster: Transketolase, central region; n=3;
Bacteria|Rep: Transketolase, central region -
Caldicellulosiruptor saccharolyticus (strain ATCC 43494
/ DSM 8903)
Length = 823
Score = 35.9 bits (79), Expect = 1.2
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 7/73 (9%)
Frame = +3
Query: 303 TSEDALKLYEQLTILRRIETASGNLYKEKIIRGF-------CHLYSGQEAVAVGMRAAMR 461
+ ED L++Y + I+R ET + G HL GQEA AVG +
Sbjct: 40 SDEDLLRIYRDMLIIREFETMLSLIKTRGEYNGIKYDYPGPAHLSIGQEAAAVGQAFILD 99
Query: 462 DADSVITAYRCHG 500
D + ++R HG
Sbjct: 100 KNDFIFGSHRSHG 112
Score = 33.1 bits (72), Expect = 8.6
Identities = 17/44 (38%), Positives = 21/44 (47%), Gaps = 2/44 (4%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNF--YGGNGIVGAQVPLGAGVXFAHK 679
R TG +G GGSMH++ F Y N IVG + G K
Sbjct: 175 RETGFQKGLGGSMHVFFPPFGIYPNNAIVGGSADIAVGAALYKK 218
>UniRef50_A1UJ85 Cluster: Pyruvate dehydrogenase; n=16;
Mycobacterium|Rep: Pyruvate dehydrogenase -
Mycobacterium sp. (strain KMS)
Length = 356
Score = 35.5 bits (78), Expect = 1.6
Identities = 14/41 (34%), Positives = 24/41 (58%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTAL 819
VT A GDGA ++G + + N+ ++ +PCVF + A+
Sbjct: 153 VTVAFLGDGATSEGDVHEAMNLAAVYQVPCVFFVQNNQWAI 193
>UniRef50_A7D3P2 Cluster: Pyruvate dehydrogenase; n=1; Halorubrum
lacusprofundi ATCC 49239|Rep: Pyruvate dehydrogenase -
Halorubrum lacusprofundi ATCC 49239
Length = 382
Score = 35.5 bits (78), Expect = 1.6
Identities = 23/72 (31%), Positives = 34/72 (47%)
Frame = +3
Query: 285 ATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRD 464
AT L+ E +Y L RR + + +L ++ I + +GQE AVG A+ D
Sbjct: 35 ATVPDLSDERFRAIYRDLVTTRRFDERAVSLQRQGRIGTYAPC-AGQEGSAVGSTHALAD 93
Query: 465 ADSVITAYRCHG 500
D + YR HG
Sbjct: 94 RDLISYQYREHG 105
>UniRef50_UPI00015B6257 Cluster: PREDICTED: similar to chromodomain
helicase DNA binding protein; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to chromodomain
helicase DNA binding protein - Nasonia vitripennis
Length = 4629
Score = 35.1 bits (77), Expect = 2.1
Identities = 21/66 (31%), Positives = 30/66 (45%)
Frame = -2
Query: 711 QSERDSPSARYLWAKXTPAPNGTCAPTIPLPP*KLRPYKCMEPPLPREQPVLRPVSSEST 532
Q + P+ +Y AK +P A P RP PP ++Q RP+ S +
Sbjct: 315 QPQHPGPTPQYGPAKHATSPQYRAAFPQLSPQMSPRPQMSPRPPAVQQQMSPRPIMSPAK 374
Query: 531 PSTLTP 514
PSTL+P
Sbjct: 375 PSTLSP 380
>UniRef50_UPI000069F43F Cluster: Short transient receptor potential
channel 6 (TrpC6).; n=1; Xenopus tropicalis|Rep: Short
transient receptor potential channel 6 (TrpC6). -
Xenopus tropicalis
Length = 806
Score = 35.1 bits (77), Expect = 2.1
Identities = 29/80 (36%), Positives = 40/80 (50%), Gaps = 6/80 (7%)
Frame = +3
Query: 165 RKHNHESDCTGCSDKRKIQHEKRGDIRNQAYKLHKLDQGPATSA--TLTSED----ALKL 326
R H++ CT CS+K+K R AYK G A+ A +L+SED AL+L
Sbjct: 173 RPHDYFCKCTECSEKQKHDSFSHSRSRINAYK------GLASPAYLSLSSEDPVMTALEL 226
Query: 327 YEQLTILRRIETASGNLYKE 386
+L +L IE N YK+
Sbjct: 227 SNELAVLANIEKEFKNDYKK 246
>UniRef50_Q5SJR9 Cluster: Pyruvate dehydrogenase (Lipoamide) (EC
1.2.4.1) E1-alpha chain; n=2; Thermus thermophilus|Rep:
Pyruvate dehydrogenase (Lipoamide) (EC 1.2.4.1) E1-alpha
chain - Thermus thermophilus (strain HB8 / ATCC 27634 /
DSM 579)
Length = 346
Score = 35.1 bits (77), Expect = 2.1
Identities = 20/64 (31%), Positives = 34/64 (53%)
Frame = +3
Query: 300 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 479
L E+AL+LY + R + + L ++ + G + GQEA VG+ A+ + D V+
Sbjct: 16 LAEEEALRLYRAMRRARFFDEKALTLQRQGRL-GVYAPFMGQEAAQVGVALALEERDWVV 74
Query: 480 TAYR 491
+YR
Sbjct: 75 PSYR 78
>UniRef50_A3RZM3 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=5; Proteobacteria|Rep: Pyruvate dehydrogenase
E1 component alpha subunit - Ralstonia solanacearum
UW551
Length = 368
Score = 35.1 bits (77), Expect = 2.1
Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 6/78 (7%)
Frame = +3
Query: 318 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 497
L LY + + R +T + L + + F GQEA+ VG+ +AMR D + +YR H
Sbjct: 36 LALYRAMVLTRAFDTKAIALQRTGKLGTFASSV-GQEAIGVGVASAMRAEDVLFPSYRDH 94
Query: 498 ------GWTYSWALVCWG 533
G + + +L+ WG
Sbjct: 95 SAQLLRGVSMAESLLYWG 112
>UniRef50_A6SG69 Cluster: Putative uncharacterized protein; n=2;
Sclerotiniaceae|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 1355
Score = 35.1 bits (77), Expect = 2.1
Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Frame = -2
Query: 663 TPAPNGTCAPTIPLPP*--KLRPYKCMEPPLPREQPVLRPVSSESTPSTLTPMSKSIR 496
TPAP P P PP +P+ EP PR+ P+ P+ + P L P+S++ +
Sbjct: 18 TPAPPRFNQPPPPQPPLFRPPQPHAGREPTPPRDGPIPPPIQPQILPQPLLPISRAAK 75
>UniRef50_Q93N50 Cluster: Pyruvate dehydrogenase alpha subunit; n=4;
Proteobacteria|Rep: Pyruvate dehydrogenase alpha subunit
- Coxiella burnetii
Length = 341
Score = 34.7 bits (76), Expect = 2.8
Identities = 17/44 (38%), Positives = 25/44 (56%), Gaps = 2/44 (4%)
Frame = +2
Query: 560 TGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVXFAHKYR 685
TG + G+GGSM+L + F IV VP+G G+ F+ K +
Sbjct: 89 TGATAGRGGSMNLSDLSVGFVASTAIVANTVPIGVGLAFSQKLK 132
>UniRef50_Q83DQ6 Cluster: Dehydrogenase, E1 component, alpha
subunit; n=3; Coxiella burnetii|Rep: Dehydrogenase, E1
component, alpha subunit - Coxiella burnetii
Length = 368
Score = 34.7 bits (76), Expect = 2.8
Identities = 25/78 (32%), Positives = 38/78 (48%), Gaps = 6/78 (7%)
Frame = +3
Query: 318 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRC- 494
L LY ++ ++R+++ + NL + + G GQEAV +GM +AM+ D YR
Sbjct: 39 LYLYRRMALIRQLDNKAINLQRTGKM-GTYPSSRGQEAVGIGMGSAMQKEDIFCPYYRDQ 97
Query: 495 -----HGWTYSWALVCWG 533
HG S L WG
Sbjct: 98 GALFEHGIKLSEILAYWG 115
>UniRef50_A7K3C9 Cluster: Dehydrogenase E1 component superfamily;
n=10; Gammaproteobacteria|Rep: Dehydrogenase E1
component superfamily - Vibrio sp. Ex25
Length = 398
Score = 34.7 bits (76), Expect = 2.8
Identities = 19/61 (31%), Positives = 26/61 (42%)
Frame = +1
Query: 637 CAGPVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTA 816
C VG S L+ Q + GDG ++G L S N W++P VFV A
Sbjct: 172 CTHAVGVASALKIQ--GNHEAALVMCGDGGTSKGDFLESINCAGAWNIPLVFVVNNNQWA 229
Query: 817 L 819
+
Sbjct: 230 I 230
>UniRef50_Q16ZU1 Cluster: Putative uncharacterized protein; n=2; Aedes
aegypti|Rep: Putative uncharacterized protein - Aedes
aegypti (Yellowfever mosquito)
Length = 1636
Score = 34.7 bits (76), Expect = 2.8
Identities = 17/36 (47%), Positives = 21/36 (58%)
Frame = -2
Query: 606 RPYKCMEPPLPREQPVLRPVSSESTPSTLTPMSKSI 499
+P+ C PPLP P L PVSS P+T T SK +
Sbjct: 1425 KPFPCTVPPLP---PTLLPVSSTPLPTTPTAESKDV 1457
>UniRef50_Q7S5L7 Cluster: Predicted protein; n=1; Neurospora
crassa|Rep: Predicted protein - Neurospora crassa
Length = 596
Score = 34.3 bits (75), Expect = 3.7
Identities = 17/61 (27%), Positives = 27/61 (44%)
Frame = -2
Query: 663 TPAPNGTCAPTIPLPP*KLRPYKCMEPPLPREQPVLRPVSSESTPSTLTPMSKSIRDNDT 484
TPAP T P + PP + PP+ + PV+ + + P+ + P SI T
Sbjct: 60 TPAPAATSPPAVVAPPPAATKTQPASPPVVTQPPVVVAPPATTAPAVVKPSPTSITPQPT 119
Query: 483 R 481
+
Sbjct: 120 K 120
>UniRef50_Q8U4T5 Cluster: 2-oxo acid dehydrogenase subunit E1; n=1;
Haloferax volcanii|Rep: 2-oxo acid dehydrogenase subunit
E1 - Halobacterium volcanii (Haloferax volcanii)
Length = 353
Score = 34.3 bits (75), Expect = 3.7
Identities = 18/45 (40%), Positives = 23/45 (51%), Gaps = 1/45 (2%)
Frame = +2
Query: 554 RRTGCSRGKGGSMHLYGRNF-YGGNGIVGAQVPLGAGVXFAHKYR 685
R+TG RGKGG MHL+ + + GI+ P G A K R
Sbjct: 97 RKTGLCRGKGGHMHLFDPDVNFACAGIIAQGCPPAVGAAMAAKKR 141
Score = 34.3 bits (75), Expect = 3.7
Identities = 16/33 (48%), Positives = 20/33 (60%)
Frame = +1
Query: 697 VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFV 795
V A G+GA +QG L S N+ + DLP VFV
Sbjct: 146 VAVAFLGEGAIDQGGFLESLNLAAVHDLPVVFV 178
>UniRef50_Q9P2K3 Cluster: REST corepressor 3; n=25; Tetrapoda|Rep:
REST corepressor 3 - Homo sapiens (Human)
Length = 495
Score = 34.3 bits (75), Expect = 3.7
Identities = 22/64 (34%), Positives = 28/64 (43%), Gaps = 5/64 (7%)
Frame = -2
Query: 729 GGSVSVQSERDSPSARYLWAKXTPAPNGTCAPTIPL-----PP*KLRPYKCMEPPLPREQ 565
G S + E +P A PAP+ T PT P+ PP LRP P L R+
Sbjct: 373 GKSTDEEEEAQTPQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQP 432
Query: 564 PVLR 553
P L+
Sbjct: 433 PPLQ 436
>UniRef50_Q756F4 Cluster: DNA repair and recombination protein
RAD52; n=1; Eremothecium gossypii|Rep: DNA repair and
recombination protein RAD52 - Ashbya gossypii (Yeast)
(Eremothecium gossypii)
Length = 435
Score = 34.3 bits (75), Expect = 3.7
Identities = 20/48 (41%), Positives = 23/48 (47%), Gaps = 1/48 (2%)
Frame = -2
Query: 660 PAPNGTCAPTIPLP-P*KLRPYKCMEPPLPREQPVLRPVSSESTPSTL 520
PAP AP P P P +RP P P E P+ RP SSE+ L
Sbjct: 189 PAPKKRNAPLPPAPRPGAMRPEAAHAAPAPSEPPLERPRSSENDQEDL 236
>UniRef50_UPI00005103B4 Cluster: COG1071: Pyruvate/2-oxoglutarate
dehydrogenase complex, dehydrogenase (E1) component,
eukaryotic type, alpha subunit; n=1; Brevibacterium
linens BL2|Rep: COG1071: Pyruvate/2-oxoglutarate
dehydrogenase complex, dehydrogenase (E1) component,
eukaryotic type, alpha subunit - Brevibacterium linens
BL2
Length = 368
Score = 33.9 bits (74), Expect = 4.9
Identities = 13/40 (32%), Positives = 21/40 (52%)
Frame = +1
Query: 700 TFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTAL 819
T GDGA+++G ++N +W P VFV + A+
Sbjct: 164 TLTFLGDGASSEGDTHEAFNFASVWQTPTVFVLQNNQYAI 203
Score = 33.1 bits (72), Expect = 8.6
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Frame = +3
Query: 267 KLDQGPATSATLTSEDALK-LYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG 443
+L P + S+ AL LY Q+ ++RR E +L ++ + + +GQEA VG
Sbjct: 26 RLTDTPTEGLRIPSDAALTGLYRQMVLVRRFEAQVTHLTRQGRLATYPSA-AGQEAAEVG 84
Query: 444 MRAAMRDADSVITAYR 491
A+ D + YR
Sbjct: 85 ATTALAPNDWLFPTYR 100
>UniRef50_Q9VEJ1 Cluster: CG5836-PA; n=10; Eumetazoa|Rep: CG5836-PA
- Drosophila melanogaster (Fruit fly)
Length = 787
Score = 33.9 bits (74), Expect = 4.9
Identities = 22/73 (30%), Positives = 32/73 (43%)
Frame = -2
Query: 729 GGSVSVQSERDSPSARYLWAKXTPAPNGTCAPTIPLPP*KLRPYKCMEPPLPREQPVLRP 550
G ++ S + A PAP GT AP P+PP + +PP P +P+ P
Sbjct: 666 GHGLAAMDHGMSLGMEHAMAAYVPAPPGTQAPP-PMPPPLMPWMSAPQPPPPATEPLNPP 724
Query: 549 VSSESTPSTLTPM 511
+ P TL P+
Sbjct: 725 I-----PGTLPPL 732
>UniRef50_A4RA81 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 471
Score = 33.9 bits (74), Expect = 4.9
Identities = 25/62 (40%), Positives = 27/62 (43%), Gaps = 1/62 (1%)
Frame = -2
Query: 699 DSPSARYLWAKXTPAPNGTCAPTIPLPP*KLRPYKCMEPPLPREQP-VLRPVSSESTPST 523
D RY+ A P P T P IP P P P P E P V PV STPST
Sbjct: 323 DPSMGRYVLAGVPPLPTTTMVPRIPPPSVPPTP-----APAPVEAPGVDVPVEMPSTPST 377
Query: 522 LT 517
+T
Sbjct: 378 VT 379
>UniRef50_A0LLM4 Cluster: Pyruvate dehydrogenase; n=1;
Syntrophobacter fumaroxidans MPOB|Rep: Pyruvate
dehydrogenase - Syntrophobacter fumaroxidans (strain DSM
10017 / MPOB)
Length = 365
Score = 33.5 bits (73), Expect = 6.5
Identities = 16/54 (29%), Positives = 28/54 (51%), Gaps = 2/54 (3%)
Frame = +1
Query: 664 GLRPQVPRRRG--VTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTAL 819
GL + R+G V A +GDGA ++G + N ++ +P VF+ + A+
Sbjct: 143 GLAYGIKYRKGKNVAMAFFGDGATSEGDFHEALNFASVFQVPAVFICQNNHWAI 196
>UniRef50_Q9W554 Cluster: CG14814-PB, isoform B; n=5;
Sophophora|Rep: CG14814-PB, isoform B - Drosophila
melanogaster (Fruit fly)
Length = 1052
Score = 33.5 bits (73), Expect = 6.5
Identities = 25/70 (35%), Positives = 32/70 (45%), Gaps = 1/70 (1%)
Frame = -2
Query: 747 KKLTLVGGSVSVQSERDSPSARYLWAKXTPAPNGTCAPTIPLPP*KLRPYKCMEP-PLPR 571
KKL + G + +SP + L K P P GT P PP P K + P PR
Sbjct: 720 KKLGI--GQQGQTTPHESPILKLLTPKTAP-PKGTAPPKTSAPPKVSTPPKSTKQIPKPR 776
Query: 570 EQPVLRPVSS 541
+Q L PV+S
Sbjct: 777 KQKDLSPVAS 786
>UniRef50_Q2Y5G9 Cluster: TonB-like; n=1; Nitrosospira multiformis
ATCC 25196|Rep: TonB-like - Nitrosospira multiformis
(strain ATCC 25196 / NCIMB 11849)
Length = 353
Score = 33.1 bits (72), Expect = 8.6
Identities = 16/55 (29%), Positives = 23/55 (41%)
Frame = -2
Query: 678 LWAKXTPAPNGTCAPTIPLPP*KLRPYKCMEPPLPREQPVLRPVSSESTPSTLTP 514
LW+ PAP P PP + P ++PP + P P+ TP+ P
Sbjct: 49 LWSSLPPAPAPVVRAAPPPPPKPVEPMPEVKPPETKPLPKPEPLPQPETPTPSKP 103
>UniRef50_Q9RPS5 Cluster: TPP-dependent branched-chain alpha-keto
acid dehydrogenase, E1 alpha subunit; n=3;
Lactobacillales|Rep: TPP-dependent branched-chain
alpha-keto acid dehydrogenase, E1 alpha subunit -
Enterococcus faecalis (Streptococcus faecalis)
Length = 330
Score = 33.1 bits (72), Expect = 8.6
Identities = 16/58 (27%), Positives = 28/58 (48%)
Frame = +1
Query: 646 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLLRSYNMLKLWDLPCVFVARTTVTAL 819
P+ + G Q+ + V G+G+ANQG++ + N + LP +FV A+
Sbjct: 130 PLATGVGYAAQLQKADFVALTTTGEGSANQGEVQEAINFAGVKKLPVIFVVENNEYAI 187
>UniRef50_A6X0T5 Cluster: Putative uncharacterized protein; n=1;
Ochrobactrum anthropi ATCC 49188|Rep: Putative
uncharacterized protein - Ochrobactrum anthropi (strain
ATCC 49188 / DSM 6882 / NCTC 12168)
Length = 425
Score = 33.1 bits (72), Expect = 8.6
Identities = 18/53 (33%), Positives = 22/53 (41%)
Frame = -2
Query: 639 APTIPLPP*KLRPYKCMEPPLPREQPVLRPVSSESTPSTLTPMSKSIRDNDTR 481
APT P+PP K +PP PR QP P + L P + TR
Sbjct: 185 APTAPIPPRPPVEQKSAQPPQPRPQPRPAPNYPPQPRTVLPPRPAQAQPQSTR 237
>UniRef50_A4T104 Cluster: Conserved hypothetical proline rich
protein precursor; n=2; Mycobacterium|Rep: Conserved
hypothetical proline rich protein precursor -
Mycobacterium gilvum PYR-GCK
Length = 617
Score = 33.1 bits (72), Expect = 8.6
Identities = 21/60 (35%), Positives = 27/60 (45%), Gaps = 5/60 (8%)
Frame = -2
Query: 663 TPAPNGTCAPTIPLPP*KLRPYKCMEP-----PLPREQPVLRPVSSESTPSTLTPMSKSI 499
TP P T APT PP +P P P P E PV + TP+T TP ++ +
Sbjct: 552 TPTPTSTPAPTSTPPPVTSQPVPVETPTATQEPAPAETPVTE-IPVTETPATETPATECV 610
>UniRef50_A0K283 Cluster: Pyruvate dehydrogenase; n=4;
Actinobacteria (class)|Rep: Pyruvate dehydrogenase -
Arthrobacter sp. (strain FB24)
Length = 415
Score = 33.1 bits (72), Expect = 8.6
Identities = 24/80 (30%), Positives = 37/80 (46%), Gaps = 3/80 (3%)
Frame = +3
Query: 270 LDQGPATSATLTSEDALKL---YEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAV 440
L + P SA DA KL Y + +RR + + L ++ + + L +GQEA +
Sbjct: 45 LGEDPVFSAYANRLDAEKLRGFYADMAAIRRFDQEATALQRQGQLALWVPL-TGQEAAQI 103
Query: 441 GMRAAMRDADSVITAYRCHG 500
G A + D + YR HG
Sbjct: 104 GSGRASQPQDYIFPTYREHG 123
>UniRef50_A6NGB9 Cluster: Uncharacterized protein WIPF3; n=17;
Theria|Rep: Uncharacterized protein WIPF3 - Homo sapiens
(Human)
Length = 461
Score = 33.1 bits (72), Expect = 8.6
Identities = 24/67 (35%), Positives = 26/67 (38%), Gaps = 1/67 (1%)
Frame = -2
Query: 693 PSARYLWAKXTPAPNGTCAPTIPLPP*KLRPYKCMEPPLPREQPVLRPVSSES-TPSTLT 517
P Y K PA A P PP L PY P P L V+S S TP L
Sbjct: 246 PPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLP 305
Query: 516 PMSKSIR 496
P S S +
Sbjct: 306 PKSPSFQ 312
>UniRef50_Q4PDN8 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 433
Score = 33.1 bits (72), Expect = 8.6
Identities = 16/49 (32%), Positives = 26/49 (53%)
Frame = +3
Query: 249 QAYKLHKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKII 395
Q + LH + Q P ++ +S DA KL+ + IL ++ NL K +I
Sbjct: 34 QLFTLHSIQQRPRNASNSSSPDASKLFPDVAILPDFDSVLTNLPKNGLI 82
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 821,614,868
Number of Sequences: 1657284
Number of extensions: 16870013
Number of successful extensions: 56842
Number of sequences better than 10.0: 123
Number of HSP's better than 10.0 without gapping: 52421
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 56578
length of database: 575,637,011
effective HSP length: 100
effective length of database: 409,908,611
effective search space used: 70914189703
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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