BLASTX 2.2.12 [Aug-07-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= tesV0337.Seq (742 letters) Database: uniref50 1,657,284 sequences; 575,637,011 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value UniRef50_Q9VHB8 Cluster: CG8199-PA; n=2; Eukaryota|Rep: CG8199-P... 134 2e-30 UniRef50_P12694 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 133 5e-30 UniRef50_Q295J7 Cluster: GA20891-PA; n=7; Coelomata|Rep: GA20891... 132 9e-30 UniRef50_Q4A1S8 Cluster: Putative uncharacterized protein; n=4; ... 130 3e-29 UniRef50_Q9LPL5 Cluster: Branched-chain alpha keto-acid dehydrog... 120 4e-26 UniRef50_A7RZV6 Cluster: Predicted protein; n=6; Eumetazoa|Rep: ... 120 4e-26 UniRef50_A6RV39 Cluster: Putative uncharacterized protein; n=1; ... 106 7e-22 UniRef50_Q4DB65 Cluster: 2-oxoisovalerate dehydrogenase alpha su... 100 7e-20 UniRef50_A0DAM1 Cluster: Chromosome undetermined scaffold_43, wh... 99 1e-19 UniRef50_Q4Y3F8 Cluster: Branched-chain alpha keto-acid dehydrog... 98 2e-19 UniRef50_Q4P2J0 Cluster: Putative uncharacterized protein; n=1; ... 95 1e-18 UniRef50_Q5KGR5 Cluster: Branched-chain alpha-keto acid dehydrog... 94 4e-18 UniRef50_Q1KSF2 Cluster: Mitochondrial branched-chain alpha-keto... 93 9e-18 UniRef50_Q6YPX5 Cluster: Thiamine pyrophosphate-dependent dehydr... 81 2e-14 UniRef50_Q5QUK4 Cluster: Alpha keto acid dehydrogenase complex, ... 79 1e-13 UniRef50_Q4QC52 Cluster: 2-oxoisovalerate dehydrogenase alpha su... 75 1e-12 UniRef50_Q9HN77 Cluster: Pyruvate dehydrogenase alpha subunit; n... 73 1e-11 UniRef50_A7HBV0 Cluster: 3-methyl-2-oxobutanoate dehydrogenase; ... 71 2e-11 UniRef50_Q9YBC0 Cluster: Pyruvate dehydrogenase E1 component, al... 69 1e-10 UniRef50_P35485 Cluster: Pyruvate dehydrogenase E1 component sub... 69 2e-10 UniRef50_Q4N1L6 Cluster: Branched-chain alpha keto-acid dehydrog... 67 5e-10 UniRef50_Q4L1A7 Cluster: Pyruvate dehydrogenase E1 component alp... 58 2e-07 UniRef50_Q5KUY4 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 58 3e-07 UniRef50_Q8CX87 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 57 5e-07 UniRef50_A6CP23 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 55 2e-06 UniRef50_P21873 Cluster: Pyruvate dehydrogenase E1 component sub... 55 2e-06 UniRef50_P47516 Cluster: Pyruvate dehydrogenase E1 component sub... 54 3e-06 UniRef50_A1UJ85 Cluster: Pyruvate dehydrogenase; n=16; Mycobacte... 54 4e-06 UniRef50_A7K3C9 Cluster: Dehydrogenase E1 component superfamily;... 54 5e-06 UniRef50_Q97CK0 Cluster: 2-oxoisovalerate dehydrogenase alpha su... 53 9e-06 UniRef50_Q835M4 Cluster: Pyruvate dehydrogenase complex E1 compo... 52 1e-05 UniRef50_A7D3P2 Cluster: Pyruvate dehydrogenase; n=1; Halorubrum... 52 2e-05 UniRef50_A0LLM4 Cluster: Pyruvate dehydrogenase; n=1; Syntrophob... 50 5e-05 UniRef50_Q0W151 Cluster: Pyruvate dehydrogenase complex E1, tran... 50 6e-05 UniRef50_A5UU15 Cluster: Pyruvate dehydrogenase; n=3; Chloroflex... 50 8e-05 UniRef50_Q9KG99 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 49 1e-04 UniRef50_A0K283 Cluster: Pyruvate dehydrogenase; n=4; Actinobact... 49 1e-04 UniRef50_UPI00005103B4 Cluster: COG1071: Pyruvate/2-oxoglutarate... 48 2e-04 UniRef50_Q4MTG0 Cluster: Pyruvate dehydrogenase E1 component sub... 48 2e-04 UniRef50_Q8EVQ2 Cluster: Pyruvate dehydrogenase E1 component sub... 48 3e-04 UniRef50_P09060 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 48 3e-04 UniRef50_A0JUQ5 Cluster: Pyruvate dehydrogenase; n=4; Actinobact... 47 4e-04 UniRef50_Q6L1L8 Cluster: Pyruvate dehydrogenase E1 component alp... 46 7e-04 UniRef50_Q1LFS5 Cluster: Dehydrogenase, E1 component; n=22; Prot... 46 0.001 UniRef50_Q2J998 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp... 45 0.002 UniRef50_Q3W421 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp... 45 0.002 UniRef50_O48615 Cluster: Alpha-keto acid dehydrogenase-like prot... 45 0.002 UniRef50_Q1AZ54 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacte... 44 0.003 UniRef50_Q9RYC1 Cluster: 2-oxo acid dehydrogenase, E1 component,... 44 0.005 UniRef50_A3RZM3 Cluster: Pyruvate dehydrogenase E1 component alp... 44 0.005 UniRef50_P37940 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 44 0.005 UniRef50_Q5SJR9 Cluster: Pyruvate dehydrogenase (Lipoamide) (EC ... 43 0.009 UniRef50_A6GB57 Cluster: Pyruvate dehydrogenase; n=1; Plesiocyst... 43 0.009 UniRef50_A0M1U4 Cluster: 2-oxoisovalerate dehydrogenase E1 compo... 43 0.009 UniRef50_Q749T8 Cluster: Pyruvate dehydrogenase complex E1 compo... 42 0.012 UniRef50_Q49108 Cluster: Pyruvate dehydrogenase EI alpha subunit... 42 0.012 UniRef50_Q12FH4 Cluster: Pyruvate dehydrogenase; n=37; Bacteria|... 42 0.012 UniRef50_A5IXN2 Cluster: Pyruvate dehydrogenase E1 component, al... 41 0.028 UniRef50_Q53610 Cluster: Branched-chain alpha-keto acid dehydrog... 40 0.049 UniRef50_A0JY23 Cluster: Pyruvate dehydrogenase; n=2; Arthrobact... 40 0.049 UniRef50_Q8D6Q7 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 40 0.064 UniRef50_Q83DQ6 Cluster: Dehydrogenase, E1 component, alpha subu... 40 0.064 UniRef50_Q83FF2 Cluster: Pyruvate dehydrogenase E1 component alp... 40 0.085 UniRef50_A6WG12 Cluster: Pyruvate dehydrogenase; n=3; Actinomyce... 40 0.085 UniRef50_Q72GU1 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 40 0.085 UniRef50_Q5LVW0 Cluster: Dehydrogenase/transketolase family prot... 39 0.15 UniRef50_Q9RPS5 Cluster: TPP-dependent branched-chain alpha-keto... 38 0.20 UniRef50_Q7N5R1 Cluster: Similar to 3-methyl-2-oxobutanoate dehy... 38 0.26 UniRef50_Q3DYK5 Cluster: Dehydrogenase, E1 component; n=3; Bacte... 38 0.26 UniRef50_Q1IY28 Cluster: Pyruvate dehydrogenase; n=1; Deinococcu... 38 0.26 UniRef50_Q67SE7 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 38 0.34 UniRef50_P16387 Cluster: Pyruvate dehydrogenase E1 component sub... 38 0.34 UniRef50_Q6A611 Cluster: Pyruvate dehydrogenase E1 component, al... 37 0.45 UniRef50_A4F1Y5 Cluster: Branched-chain alpha-keto acid decarbox... 37 0.45 UniRef50_Q1EGI2 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 36 1.4 UniRef50_Q9HNV6 Cluster: Pyruvate dehydrogenase alpha subunit; n... 36 1.4 UniRef50_Q74AD3 Cluster: Dehydrogenase complex, E1 component, al... 35 1.8 UniRef50_Q2BFQ9 Cluster: Putative uncharacterized protein; n=1; ... 35 1.8 UniRef50_Q67ME6 Cluster: Branched-chain alpha-keto acid dehydrog... 35 2.4 UniRef50_Q479Q2 Cluster: Dehydrogenase, E1 component; n=2; Rhodo... 35 2.4 UniRef50_Q02C52 Cluster: Pyruvate dehydrogenase; n=1; Solibacter... 35 2.4 UniRef50_A0LSF3 Cluster: Pyruvate dehydrogenase; n=5; Bacteria|R... 35 2.4 UniRef50_Q8YNY8 Cluster: Asr4421 protein; n=1; Nostoc sp. PCC 71... 34 4.2 UniRef50_A6DTS3 Cluster: Dehydrogenase complex, E1 component, al... 34 4.2 UniRef50_Q8ZUR8 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 34 4.2 UniRef50_Q2JA37 Cluster: Pyruvate dehydrogenase; n=11; Actinomyc... 33 7.4 UniRef50_A7GY08 Cluster: Ferric uptake regulation protein; n=2; ... 33 7.4 UniRef50_A3S1N4 Cluster: Putative uncharacterized protein; n=1; ... 33 7.4 UniRef50_Q1XDM0 Cluster: Pyruvate dehydrogenase E1 component sub... 33 7.4 UniRef50_Q5DY55 Cluster: Putative uncharacterized protein; n=1; ... 33 9.7 >UniRef50_Q9VHB8 Cluster: CG8199-PA; n=2; Eukaryota|Rep: CG8199-PA - Drosophila melanogaster (Fruit fly) Length = 439 Score = 134 bits (324), Expect = 2e-30 Identities = 60/118 (50%), Positives = 82/118 (69%) Frame = +3 Query: 255 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHM 434 GA+AP+VS++ Y PIPIYRVMD +G I D+ ++P L + + M++ MV L+ M Sbjct: 48 GAKAPFVSKLNLIQPEDYAPIPIYRVMDQDGYIADETQDPQLGREVVEKMFRDMVLLNTM 107 Query: 435 DKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608 DKILYESQRQGRISFYMTN+GEE + AL +DL++ QYRE GV ++RG + + Sbjct: 108 DKILYESQRQGRISFYMTNFGEEASHIGSAAALEMRDLIYGQYREAGVLVWRGFRIDQ 165 Score = 54.8 bits (126), Expect = 2e-06 Identities = 21/34 (61%), Positives = 28/34 (82%) Frame = +1 Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708 + ++QCYGN +D G+G+QMPVHYGS+ N VTIS Sbjct: 165 QFIDQCYGNTDDLGRGKQMPVHYGSRELNFVTIS 198 >UniRef50_P12694 Cluster: 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor; n=29; Euteleostomi|Rep: 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor - Homo sapiens (Human) Length = 445 Score = 133 bits (321), Expect = 5e-30 Identities = 62/112 (55%), Positives = 79/112 (70%) Frame = +3 Query: 255 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHM 434 GA A ++ +++F IPIYRVMD GQII+ +E+P+L K ++ +YK+M L+ M Sbjct: 56 GASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTM 115 Query: 435 DKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYR 590 D+ILYESQRQGRISFYMTNYGEEG + AL DLVF QYRE GV +YR Sbjct: 116 DRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYR 167 Score = 52.8 bits (121), Expect = 9e-06 Identities = 22/30 (73%), Positives = 23/30 (76%) Frame = +1 Query: 619 QCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708 QCYGN D GKGRQMPVHYG K + VTIS Sbjct: 177 QCYGNISDLGKGRQMPVHYGCKERHFVTIS 206 >UniRef50_Q295J7 Cluster: GA20891-PA; n=7; Coelomata|Rep: GA20891-PA - Drosophila pseudoobscura (Fruit fly) Length = 439 Score = 132 bits (319), Expect = 9e-30 Identities = 60/118 (50%), Positives = 83/118 (70%) Frame = +3 Query: 255 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHM 434 GA+AP+VS++K Y PIPIYRVMD +G I D+ ++P L + + M++ M+ L+ M Sbjct: 48 GAKAPFVSKLKLNMPEDYAPIPIYRVMDRDGFIADETQDPQLGREVVEKMFRDMLLLNTM 107 Query: 435 DKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608 DKILYESQRQGRISFYMTN+GEE + AL +DL++ QYRE GV ++RG + + Sbjct: 108 DKILYESQRQGRISFYMTNFGEEASHIGSAAALEMRDLIYGQYREAGVLVWRGFRIDQ 165 Score = 54.8 bits (126), Expect = 2e-06 Identities = 21/34 (61%), Positives = 28/34 (82%) Frame = +1 Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708 + ++QCYGN +D G+G+QMPVHYGS+ N VTIS Sbjct: 165 QFIDQCYGNVDDLGRGKQMPVHYGSRELNFVTIS 198 >UniRef50_Q4A1S8 Cluster: Putative uncharacterized protein; n=4; Caenorhabditis|Rep: Putative uncharacterized protein - Caenorhabditis elegans Length = 432 Score = 130 bits (315), Expect = 3e-29 Identities = 58/114 (50%), Positives = 82/114 (71%) Frame = +3 Query: 261 RAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDK 440 +A + +++ N +PIYRV + G +IDK+++PN D+ T + MYKTM QL+ MD+ Sbjct: 42 KAAFTEKLEIVNADDTPALPIYRVTNAVGDVIDKSQDPNFDEQTSLKMYKTMTQLNIMDR 101 Query: 441 ILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTV 602 ILY+SQRQGRISFYMT++GEEG + AL P+DL++ QYRE GV L+RG T+ Sbjct: 102 ILYDSQRQGRISFYMTSFGEEGNHVGSAAALEPQDLIYGQYREAGVLLWRGYTM 155 Score = 56.8 bits (131), Expect = 5e-07 Identities = 22/32 (68%), Positives = 27/32 (84%) Frame = +1 Query: 613 VNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708 +NQCYGN +D GKGRQMP+H+G+K N VTIS Sbjct: 159 MNQCYGNADDLGKGRQMPMHFGTKERNFVTIS 190 >UniRef50_Q9LPL5 Cluster: Branched-chain alpha keto-acid dehydrogenase E1-alpha subunit; n=13; Magnoliophyta|Rep: Branched-chain alpha keto-acid dehydrogenase E1-alpha subunit - Arabidopsis thaliana (Mouse-ear cress) Length = 472 Score = 120 bits (289), Expect = 4e-26 Identities = 59/118 (50%), Positives = 77/118 (65%) Frame = +3 Query: 255 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHM 434 G + Y SEMKF E+S IP YRV+D +G+II ++ + + + MY+ M L M Sbjct: 84 GGKVGYTSEMKFIPESSSRRIPCYRVLDEDGRIIPDSDFIPVSEKLAVRMYEQMATLQVM 143 Query: 435 DKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608 D I YE+QRQGRISFY+T+ GEE I A+ ALSP D+V QYRE GV L+RG T+ E Sbjct: 144 DHIFYEAQRQGRISFYLTSVGEEAINIASAAALSPDDVVLPQYREPGVLLWRGFTLEE 201 Score = 50.8 bits (116), Expect = 3e-05 Identities = 21/34 (61%), Positives = 24/34 (70%) Frame = +1 Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708 + NQC+GN D GKGRQMP+HYGS N TIS Sbjct: 201 EFANQCFGNKADYGKGRQMPIHYGSNRLNYFTIS 234 >UniRef50_A7RZV6 Cluster: Predicted protein; n=6; Eumetazoa|Rep: Predicted protein - Nematostella vectensis Length = 444 Score = 120 bits (289), Expect = 4e-26 Identities = 54/98 (55%), Positives = 71/98 (72%) Frame = +3 Query: 315 IPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY 494 IP+YRVMD G+II + +P L + T+++MYK M L+ MD+ILYESQRQGRISFYMTNY Sbjct: 74 IPVYRVMDRQGKIIIDSHDPKLPEGTIVDMYKKMTLLNTMDRILYESQRQGRISFYMTNY 133 Query: 495 GEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608 GEE + AL +DL+ QYRE GV ++RG T+ + Sbjct: 134 GEEATHFGSAAALEMEDLIMGQYREAGVLMWRGFTLAD 171 Score = 56.0 bits (129), Expect = 9e-07 Identities = 24/32 (75%), Positives = 25/32 (78%) Frame = +1 Query: 613 VNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708 +NQCY N D GKGRQMPVHYGSK N VTIS Sbjct: 173 MNQCYANQHDAGKGRQMPVHYGSKELNFVTIS 204 >UniRef50_A6RV39 Cluster: Putative uncharacterized protein; n=1; Botryotinia fuckeliana B05.10|Rep: Putative uncharacterized protein - Botryotinia fuckeliana B05.10 Length = 211 Score = 106 bits (254), Expect = 7e-22 Identities = 55/136 (40%), Positives = 81/136 (59%), Gaps = 1/136 (0%) Frame = +3 Query: 246 RISGA-RAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQ 422 R GA + + S + F + ++Y IP YR M +G+I+D + D+A L MY M++ Sbjct: 52 RFPGAVDSKFTSSLSFEHPSTYNAIPTYRTMSPDGEILDPSAVLPSDEAAL-EMYLNMIK 110 Query: 423 LSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTV 602 +S MD I+ E+QRQGR+SFYM + GEEG + AL D++FSQYRE GVF+ RG T+ Sbjct: 111 VSIMDVIMVEAQRQGRLSFYMPSQGEEGTCVGSAAALEKDDVIFSQYREAGVFMQRGFTL 170 Query: 603 TETCEPVLRKLRGSGE 650 E + + G+ Sbjct: 171 DEFMSQLFANRKDKGK 186 Score = 40.3 bits (90), Expect = 0.049 Identities = 16/32 (50%), Positives = 23/32 (71%) Frame = +1 Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVT 702 + ++Q + N +D GK R MPVHYGSK N+V+ Sbjct: 172 EFMSQLFANRKDKGKARNMPVHYGSKELNIVS 203 >UniRef50_Q4DB65 Cluster: 2-oxoisovalerate dehydrogenase alpha subunit, putative; n=3; Trypanosoma|Rep: 2-oxoisovalerate dehydrogenase alpha subunit, putative - Trypanosoma cruzi Length = 431 Score = 99.5 bits (237), Expect = 7e-20 Identities = 48/114 (42%), Positives = 70/114 (61%) Frame = +3 Query: 267 PYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKIL 446 P V E+ F ++ Y P++ V+D +G++++ +EP + K TLI M + M++ +D IL Sbjct: 45 PTVDELTF-HQRKYPSTPMFHVLDLDGRVVNPKQEPEVPKETLIKMMEAMLRQQSIDLIL 103 Query: 447 YESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608 E+QRQGRISFYMT+ GEE AL +D +F QYRE YRG TV + Sbjct: 104 MEAQRQGRISFYMTSMGEEASAVGTAAALDMRDELFLQYREAAALTYRGYTVKD 157 Score = 41.5 bits (93), Expect = 0.021 Identities = 18/35 (51%), Positives = 24/35 (68%) Frame = +1 Query: 604 RKLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708 + +V QC G E+ KGRQMP+HYGS+ N+ IS Sbjct: 156 KDMVAQCMGTIENELKGRQMPIHYGSRALNVHMIS 190 >UniRef50_A0DAM1 Cluster: Chromosome undetermined scaffold_43, whole genome shotgun sequence; n=3; Oligohymenophorea|Rep: Chromosome undetermined scaffold_43, whole genome shotgun sequence - Paramecium tetraurelia Length = 406 Score = 98.7 bits (235), Expect = 1e-19 Identities = 45/102 (44%), Positives = 66/102 (64%) Frame = +3 Query: 303 SYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFY 482 ++EPI +RV+D G ++ K E N+ K L ++ M+ + MD +LY SQRQG+ISFY Sbjct: 30 NFEPIKQFRVIDLEGNLVAK-EYNNIPKEILNQIFDLMISIEEMDNLLYMSQRQGKISFY 88 Query: 483 MTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608 MT++GE T AL P+D +F QYRE G F++RG T+ + Sbjct: 89 MTSFGETATTVGTTAALQPQDFIFPQYREQGSFMWRGFTIEQ 130 Score = 55.6 bits (128), Expect = 1e-06 Identities = 24/34 (70%), Positives = 28/34 (82%) Frame = +1 Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708 ++VNQC GN D GKGRQMPVHYGSK N+VT+S Sbjct: 130 QIVNQCIGNHLDGGKGRQMPVHYGSKDLNIVTVS 163 >UniRef50_Q4Y3F8 Cluster: Branched-chain alpha keto-acid dehydrogenase, putative; n=7; Plasmodium|Rep: Branched-chain alpha keto-acid dehydrogenase, putative - Plasmodium chabaudi Length = 432 Score = 98.3 bits (234), Expect = 2e-19 Identities = 51/125 (40%), Positives = 78/125 (62%) Frame = +3 Query: 270 YVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILY 449 + +++K NE + +PI+R++D NG ++D + P D ++N+YK MV+ S D+I Y Sbjct: 48 FSTDLKTVNEVA--KLPIFRILDTNGNLLDGHTAP-FDDEEVLNLYKQMVEFSIWDEIFY 104 Query: 450 ESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLR 629 QRQGRISFY+ N GEEG+ +AL+ D ++ QYRE G+ L RG T E +L Sbjct: 105 GIQRQGRISFYIVNDGEEGLHFGIGKALTVDDHLYCQYRETGILLSRGFTY----EDILN 160 Query: 630 KLRGS 644 +L G+ Sbjct: 161 QLFGT 165 >UniRef50_Q4P2J0 Cluster: Putative uncharacterized protein; n=1; Ustilago maydis|Rep: Putative uncharacterized protein - Ustilago maydis (Smut fungus) Length = 786 Score = 95.5 bits (227), Expect = 1e-18 Identities = 48/105 (45%), Positives = 66/105 (62%), Gaps = 2/105 (1%) Frame = +3 Query: 294 NETSYEPIPIYRVMDNNGQIID--KNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQG 467 N+ S IP YR+MD G+++ E N+ + + MY+TM+ L +D ILY +QRQG Sbjct: 390 NKNSQGGIPTYRLMDGVGRLLPGVTQEMINITQQEAVKMYRTMLLLPQIDVILYNAQRQG 449 Query: 468 RISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTV 602 RISF MT+YGEEG + L KD VF+QYRE GV L+R ++ Sbjct: 450 RISFMMTSYGEEGAVIGSAAGLDAKDEVFAQYRESGVLLWRDFSI 494 Score = 35.9 bits (79), Expect = 1.0 Identities = 15/32 (46%), Positives = 22/32 (68%) Frame = +1 Query: 613 VNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708 ++Q +G +D GRQMP+H+GS H+ TIS Sbjct: 498 MSQVFGAEDDLCGGRQMPIHFGSTQHHFHTIS 529 >UniRef50_Q5KGR5 Cluster: Branched-chain alpha-keto acid dehydrogenase E1-alpha subunit, putative; n=2; Filobasidiella neoformans|Rep: Branched-chain alpha-keto acid dehydrogenase E1-alpha subunit, putative - Cryptococcus neoformans (Filobasidiella neoformans) Length = 504 Score = 93.9 bits (223), Expect = 4e-18 Identities = 52/153 (33%), Positives = 79/153 (51%), Gaps = 1/153 (0%) Frame = +3 Query: 276 SEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYES 455 +EM +FN + + IP +RV+D G ++ E K +++Y+TM + +D +LY+S Sbjct: 97 AEMGWFNAVA-KTIPTFRVLDEEGHMVKDGHESQATKEQTLSIYRTMTLIPIVDNVLYQS 155 Query: 456 QRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKL 635 QRQGRISFYM GEE + A+ D +F QYRE L+RG T+ + Sbjct: 156 QRQGRISFYMQCAGEEAAIVGSAAAMLANDEIFGQYRESAALLHRGFTLDALMAQCFGNV 215 Query: 636 RGSGERETDAGPLRKQAPQHG-HNILVH*GTQI 731 G + P+ +P+HG H I TQ+ Sbjct: 216 DDKGTKGR-MMPVHYSSPEHGFHTITSPLATQM 247 >UniRef50_Q1KSF2 Cluster: Mitochondrial branched-chain alpha-keto acid dehydrogenase E1; n=1; Toxoplasma gondii|Rep: Mitochondrial branched-chain alpha-keto acid dehydrogenase E1 - Toxoplasma gondii Length = 463 Score = 92.7 bits (220), Expect = 9e-18 Identities = 49/121 (40%), Positives = 71/121 (58%) Frame = +3 Query: 270 YVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILY 449 + ++M NET IPI+R++D +GQI D + P + ++ Y+ MV+LS D + Y Sbjct: 78 FTTDMNISNETPV--IPIFRILDYDGQIADGWQCP-MTNDEVLEAYQFMVKLSIWDNMFY 134 Query: 450 ESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLR 629 QRQGRISFY+ N GEE + A AL KD +F QYRE+GV + G T + E + Sbjct: 135 SVQRQGRISFYIQNQGEEALQTAVGLALDKKDHLFCQYRELGVLMLHGFTAEDALEQLFA 194 Query: 630 K 632 + Sbjct: 195 R 195 >UniRef50_Q6YPX5 Cluster: Thiamine pyrophosphate-dependent dehydrogenase, E1 component alpha subunit; n=2; Candidatus Phytoplasma asteris|Rep: Thiamine pyrophosphate-dependent dehydrogenase, E1 component alpha subunit - Onion yellows phytoplasma Length = 363 Score = 81.4 bits (192), Expect = 2e-14 Identities = 39/103 (37%), Positives = 59/103 (57%), Gaps = 2/103 (1%) Frame = +3 Query: 306 YEPIP--IYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISF 479 Y+P+ ++++D NG ++ EP L K L+ MYKTMV D + QRQGR+ Sbjct: 6 YDPLKGKQFQILDENGNLVQPELEPKLSKDVLLKMYKTMVLGRQADLAALKYQRQGRMGN 65 Query: 480 YMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608 Y+ N G+E AL P+D V YR+ G+FLYRG+++ + Sbjct: 66 YLLNSGQEASQVGVAAALEPQDWVSPYYRDAGIFLYRGVSLEQ 108 >UniRef50_Q5QUK4 Cluster: Alpha keto acid dehydrogenase complex, E1 component, alpha subunit; n=32; Gammaproteobacteria|Rep: Alpha keto acid dehydrogenase complex, E1 component, alpha subunit - Idiomarina loihiensis Length = 395 Score = 79.0 bits (186), Expect = 1e-13 Identities = 39/112 (34%), Positives = 66/112 (58%) Frame = +3 Query: 273 VSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYE 452 V++ K+F++ S IP+ +++ +G + P DK ++ ++ TM + +D+ + Sbjct: 12 VTKPKWFDKDSVT-IPMLQILKEDGSFHKDADMPEYDKELIVKIHDTMQFIRILDERMIA 70 Query: 453 SQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608 +QRQGRISFY+ + GEE + A+ AL D++ QYRE G YRG TV + Sbjct: 71 AQRQGRISFYLASRGEEAESVASAAALDAGDMIMGQYREQGALAYRGFTVEQ 122 Score = 44.0 bits (99), Expect = 0.004 Identities = 19/34 (55%), Positives = 24/34 (70%) Frame = +1 Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708 + +NQ + N +D GKGRQMPVHYG N +TIS Sbjct: 122 QFMNQLFSNEKDLGKGRQMPVHYGCADLNFMTIS 155 >UniRef50_Q4QC52 Cluster: 2-oxoisovalerate dehydrogenase alpha subunit, putative; n=3; Leishmania|Rep: 2-oxoisovalerate dehydrogenase alpha subunit, putative - Leishmania major Length = 479 Score = 75.4 bits (177), Expect = 1e-12 Identities = 35/69 (50%), Positives = 45/69 (65%) Frame = +3 Query: 402 MYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVF 581 M M+ + MDKI+ E+QRQGRISFYMT +GEE A L+ D +F+QYRE G+ Sbjct: 124 MMSAMLTHNTMDKIMLEAQRQGRISFYMTMFGEEAAVIGAAAGLASNDELFAQYREAGIL 183 Query: 582 LYRGMTVTE 608 YRG T+ E Sbjct: 184 TYRGYTIPE 192 Score = 46.8 bits (106), Expect = 6e-04 Identities = 20/34 (58%), Positives = 24/34 (70%), Gaps = 2/34 (5%) Frame = +1 Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSK--HHNMVT 702 + + QC GNCE KGRQMP+HYGSK H MV+ Sbjct: 192 EFIAQCMGNCECDAKGRQMPIHYGSKRLHAQMVS 225 >UniRef50_Q9HN77 Cluster: Pyruvate dehydrogenase alpha subunit; n=8; Halobacteriaceae|Rep: Pyruvate dehydrogenase alpha subunit - Halobacterium salinarium (Halobacterium halobium) Length = 419 Score = 72.5 bits (170), Expect = 1e-11 Identities = 38/100 (38%), Positives = 53/100 (53%) Frame = +3 Query: 312 PIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTN 491 P YRV+D NG+++D E P+L L+ MY+ M D+ QRQGRI Y Sbjct: 57 PDDTYRVLDENGELVDGAEVPDLTDDELVEMYRYMKLARRFDERAVSLQRQGRIGTYPPL 116 Query: 492 YGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTET 611 G+EG A+ AL+ D + YRE G L RG+ + +T Sbjct: 117 SGQEGAQIASAMALADDDWIVPSYREHGASLVRGLPLKDT 156 >UniRef50_A7HBV0 Cluster: 3-methyl-2-oxobutanoate dehydrogenase; n=4; Cystobacterineae|Rep: 3-methyl-2-oxobutanoate dehydrogenase - Anaeromyxobacter sp. Fw109-5 Length = 399 Score = 71.3 bits (167), Expect = 2e-11 Identities = 36/101 (35%), Positives = 58/101 (57%), Gaps = 1/101 (0%) Frame = +3 Query: 318 PIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYG 497 P+YR++ +G+++ +E L A ++ +Y+ MV +D+ + QRQGRI FY+ + G Sbjct: 31 PLYRLVAEDGELVGAPDEVTLPDAEVLRLYRLMVLNRSLDERMITLQRQGRIGFYIGSIG 90 Query: 498 EEGIT*AAPRALSPKDLVFSQYREVGVFLYRGM-TVTETCE 617 EE + A++ D +F YRE G L RGM VT C+ Sbjct: 91 EEATILGSAAAMAESDWIFPCYREHGAALMRGMPLVTFLCD 131 >UniRef50_Q9YBC0 Cluster: Pyruvate dehydrogenase E1 component, alpha subunit; n=1; Aeropyrum pernix|Rep: Pyruvate dehydrogenase E1 component, alpha subunit - Aeropyrum pernix Length = 377 Score = 68.9 bits (161), Expect = 1e-10 Identities = 31/100 (31%), Positives = 55/100 (55%) Frame = +3 Query: 327 RVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEG 506 R +D G+++D+ P + + ++ +Y MV+ +D L + QR G+++ + N G+E Sbjct: 16 RAVDEEGRVVDEELLPKVSEGEIVEIYTYMVRARVIDSWLLKLQRMGKVALHAPNKGQEA 75 Query: 507 IT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVL 626 + A + L D VF YRE+G +L RGM+ E + L Sbjct: 76 VAVGAAKPLRRDDWVFPSYRELGAYLVRGMSEEEILDRAL 115 >UniRef50_P35485 Cluster: Pyruvate dehydrogenase E1 component subunit alpha; n=2; Firmicutes|Rep: Pyruvate dehydrogenase E1 component subunit alpha - Acholeplasma laidlawii Length = 345 Score = 68.5 bits (160), Expect = 2e-10 Identities = 34/86 (39%), Positives = 47/86 (54%) Frame = +3 Query: 336 DNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT* 515 D NG+++++ EP L K TL+ MYKT V + D + QRQGR+ Y N G+E Sbjct: 1 DQNGKVVNEKMEPKLPKETLLKMYKTAVLGRNADIKALQYQRQGRMLTYAPNMGQEAAQI 60 Query: 516 AAPRALSPKDLVFSQYREVGVFLYRG 593 A+ P+D YRE+ LYRG Sbjct: 61 GMAAAMEPQDWNSPMYRELNTLLYRG 86 >UniRef50_Q4N1L6 Cluster: Branched-chain alpha keto-acid dehydrogenase, putative; n=3; Piroplasmida|Rep: Branched-chain alpha keto-acid dehydrogenase, putative - Theileria parva Length = 464 Score = 66.9 bits (156), Expect = 5e-10 Identities = 34/89 (38%), Positives = 51/89 (57%) Frame = +3 Query: 300 TSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISF 479 T + +PI++VM +G + + ++ P + + MV+L+ D + Y QRQGRISF Sbjct: 75 TDSQVMPIFQVMKTDGTLHEGHKSPFESDEKVKEYLQIMVKLNVWDNLFYNIQRQGRISF 134 Query: 480 YMTNYGEEGIT*AAPRALSPKDLVFSQYR 566 Y+ N GEE A AL P+D +F QYR Sbjct: 135 YIQNQGEEATQLGAGLALQPQDHLFCQYR 163 Score = 35.1 bits (77), Expect = 1.8 Identities = 16/42 (38%), Positives = 24/42 (57%) Frame = +1 Query: 583 YTEG*L*RKLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708 Y +G ++ Q + +D GKGRQMP+ Y K N+ TI+ Sbjct: 179 YVKGCTEDDVLAQLFSTHKDEGKGRQMPISYSKKEVNLHTIT 220 >UniRef50_Q4L1A7 Cluster: Pyruvate dehydrogenase E1 component alpha subunit; n=9; Mycoplasma|Rep: Pyruvate dehydrogenase E1 component alpha subunit - Mycoplasma synoviae Length = 374 Score = 58.4 bits (135), Expect = 2e-07 Identities = 34/97 (35%), Positives = 47/97 (48%), Gaps = 1/97 (1%) Frame = +3 Query: 309 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 488 +P + RV+D NG +IDK +P L L+ YK MV D + + QRQGR+ + Sbjct: 20 DPSKLIRVLDVNGNLIDKKYKPQLTDKQLVEGYKWMVLSRQQDTYMLQLQRQGRMLTFAP 79 Query: 489 NYGEEGIT*AAPRAL-SPKDLVFSQYREVGVFLYRGM 596 N GEE + A AL KD +R L G+ Sbjct: 80 NLGEEALQVATAFALDKKKDWFLPAFRSNATMLALGV 116 >UniRef50_Q5KUY4 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) alpha subunit; n=2; Geobacillus|Rep: Pyruvate dehydrogenase E1 (Lipoamide) alpha subunit - Geobacillus kaustophilus Length = 359 Score = 57.6 bits (133), Expect = 3e-07 Identities = 36/110 (32%), Positives = 52/110 (47%) Frame = +3 Query: 312 PIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTN 491 P+ I R++D NG D+ + L+ Y+ M + +D+ L QRQGRI Y Sbjct: 8 PVEIVRILDENGNG-DEEKLAAFSDEWLLRAYREMRRARVIDERLLRMQRQGRIGTYAPF 66 Query: 492 YGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRG 641 G+E + AL D +F YREV V L GM + + V +L G Sbjct: 67 SGQEAAQIGSALALHKDDWIFPSYREVAVCLMHGMPLEQFFHYVQGRLSG 116 >UniRef50_Q8CX87 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) alpha subunit; n=5; Bacillaceae|Rep: Pyruvate dehydrogenase E1 (Lipoamide) alpha subunit - Oceanobacillus iheyensis Length = 358 Score = 56.8 bits (131), Expect = 5e-07 Identities = 31/99 (31%), Positives = 48/99 (48%) Frame = +3 Query: 309 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 488 E P+ R+MD NG+I D + +DKA + Y+ ++ + D+ QRQGRI Y Sbjct: 7 EEFPMIRIMDQNGKITDTSYLEQIDKALVQQFYRQLICMRAFDQKAINLQRQGRIGTYPG 66 Query: 489 NYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVT 605 G+EG + AL D + YR+ + G + T Sbjct: 67 FEGQEGAQVGSALALDEDDWMLPTYRDHAASITFGKSYT 105 >UniRef50_A6CP23 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) alpha subunit; n=2; Bacillus sp. SG-1|Rep: Pyruvate dehydrogenase E1 (Lipoamide) alpha subunit - Bacillus sp. SG-1 Length = 364 Score = 55.2 bits (127), Expect = 2e-06 Identities = 31/99 (31%), Positives = 49/99 (49%) Frame = +3 Query: 297 ETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRIS 476 E E PI R++DN+G ++ +++P + + Y+ MV++ DK QRQGRI Sbjct: 9 EEMEEQFPIKRIIDNDGTLLG-DKDPGITEQLAKEFYRHMVRIRTFDKKAISLQRQGRIG 67 Query: 477 FYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRG 593 Y G+E + AL D +F YR+ G + G Sbjct: 68 TYAPFEGQEASQVGSSAALKEDDWMFPSYRDHGAAMTFG 106 >UniRef50_P21873 Cluster: Pyruvate dehydrogenase E1 component subunit alpha; n=33; Bacilli|Rep: Pyruvate dehydrogenase E1 component subunit alpha - Bacillus stearothermophilus (Geobacillus stearothermophilus) Length = 369 Score = 54.8 bits (126), Expect = 2e-06 Identities = 25/96 (26%), Positives = 48/96 (50%) Frame = +3 Query: 309 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 488 E P +++++ G+++++ P L L + + MV +D+ RQGR+ FY Sbjct: 19 EQFPTFQILNEEGEVVNEEAMPELSDEQLKELMRRMVYTRILDQRSISLNRQGRLGFYAP 78 Query: 489 NYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596 G+E A+ AL +D + YR+V ++ G+ Sbjct: 79 TAGQEASQIASHFALEKEDFILPGYRDVPQIIWHGL 114 >UniRef50_P47516 Cluster: Pyruvate dehydrogenase E1 component subunit alpha; n=5; Mycoplasma|Rep: Pyruvate dehydrogenase E1 component subunit alpha - Mycoplasma genitalium Length = 358 Score = 54.4 bits (125), Expect = 3e-06 Identities = 31/95 (32%), Positives = 46/95 (48%) Frame = +3 Query: 312 PIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTN 491 P +Y+V DN G++ID N + L L + Y M MDK + QR G++ + N Sbjct: 10 PTTLYQVYDNEGKLIDPNHKITLTDEQLKHAYYLMNLSRMMDKKMLVWQRAGKMLNFAPN 69 Query: 492 YGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596 GEE + L+ D V +R + LYRG+ Sbjct: 70 LGEEALQVGMGLGLNENDWVCPTFRSGALMLYRGV 104 >UniRef50_A1UJ85 Cluster: Pyruvate dehydrogenase; n=16; Mycobacterium|Rep: Pyruvate dehydrogenase - Mycobacterium sp. (strain KMS) Length = 356 Score = 54.0 bits (124), Expect = 4e-06 Identities = 28/74 (37%), Positives = 39/74 (52%) Frame = +3 Query: 375 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVF 554 +L TL +Y+TMV +D QRQG ++ Y + G+E A L D +F Sbjct: 27 DLPPETLAWLYETMVVTRDLDTEFVHLQRQGELALYASCRGQEAAQIGATACLRKTDWLF 86 Query: 555 SQYREVGVFLYRGM 596 QYRE+G FL RG+ Sbjct: 87 PQYREIGAFLLRGI 100 >UniRef50_A7K3C9 Cluster: Dehydrogenase E1 component superfamily; n=10; Gammaproteobacteria|Rep: Dehydrogenase E1 component superfamily - Vibrio sp. Ex25 Length = 398 Score = 53.6 bits (123), Expect = 5e-06 Identities = 39/145 (26%), Positives = 64/145 (44%), Gaps = 1/145 (0%) Frame = +3 Query: 297 ETSYEPIPIYRVMDNNGQIIDKNEEPN-LDKATLINMYKTMVQLSHMDKILYESQRQGRI 473 E + + +P++R +D++G ++ + PN D TL+ Y+ MV D QR G++ Sbjct: 34 EMNVQALPMHRFIDHHGDLV--GQLPNWADTETLVGFYRDMVLTRTYDNKAVALQRTGKL 91 Query: 474 SFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRGSGER 653 Y ++ G E I A RAL D+ YR++ RG+ + + + G ER Sbjct: 92 GTYPSHLGAEAIGIAVGRALKADDVFVPYYRDMPAMWCRGIGMEKNLQ-----YWGGDER 146 Query: 654 ETDAGPLRKQAPQHGHNILVH*GTQ 728 +D P P V TQ Sbjct: 147 GSDFAPEGSPIPSRDLPFCVPIATQ 171 >UniRef50_Q97CK0 Cluster: 2-oxoisovalerate dehydrogenase alpha subunit; n=2; Thermoplasma|Rep: 2-oxoisovalerate dehydrogenase alpha subunit - Thermoplasma volcanium Length = 337 Score = 52.8 bits (121), Expect = 9e-06 Identities = 33/104 (31%), Positives = 53/104 (50%) Frame = +3 Query: 384 KATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQY 563 K+ + + +MV DK + +QRQG + FY G+E A ALS +DLV+ Y Sbjct: 10 KSLYVKGFTSMVLGRLFDKKVITAQRQGLVGFYTPMMGQEATQAGAAMALSKQDLVYGYY 69 Query: 564 REVGVFLYRGMTVTETCEPVLRKLRGSGERETDAGPLRKQAPQH 695 R+V + +Y G + E + ++ G+ E +T G +Q P H Sbjct: 70 RDVTLLIYLGYPI----EKIFDQIMGNAE-DTSKG---RQMPSH 105 Score = 40.3 bits (90), Expect = 0.049 Identities = 16/33 (48%), Positives = 22/33 (66%) Frame = +1 Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTI 705 K+ +Q GN ED KGRQMP HY +K N +++ Sbjct: 84 KIFDQIMGNAEDTSKGRQMPSHYSAKAVNFMSV 116 >UniRef50_Q835M4 Cluster: Pyruvate dehydrogenase complex E1 component, alpha subunit; n=10; Bacilli|Rep: Pyruvate dehydrogenase complex E1 component, alpha subunit - Enterococcus faecalis (Streptococcus faecalis) Length = 371 Score = 52.0 bits (119), Expect = 1e-05 Identities = 25/97 (25%), Positives = 51/97 (52%) Frame = +3 Query: 318 PIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYG 497 P ++++D +G+I++++ P+L L+ + MV +D+ RQGR+ F+ G Sbjct: 24 PTFQILDQDGKIVNEDLVPDLSDEELVELMTRMVWSRVLDQRSTALNRQGRLGFFAPTAG 83 Query: 498 EEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608 +E A+ A+ +D + YR+V + G+ + E Sbjct: 84 QEASQLASQFAMEKEDYLLPGYRDVPQLVQHGLPLRE 120 >UniRef50_A7D3P2 Cluster: Pyruvate dehydrogenase; n=1; Halorubrum lacusprofundi ATCC 49239|Rep: Pyruvate dehydrogenase - Halorubrum lacusprofundi ATCC 49239 Length = 382 Score = 51.6 bits (118), Expect = 2e-05 Identities = 29/91 (31%), Positives = 44/91 (48%) Frame = +3 Query: 324 YRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 503 YRV+ +G + P+L +Y+ +V D+ QRQGRI Y G+E Sbjct: 22 YRVLGPDGIPLPDATVPDLSDERFRAIYRDLVTTRRFDERAVSLQRQGRIGTYAPCAGQE 81 Query: 504 GIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596 G + AL+ +DL+ QYRE G + R + Sbjct: 82 GSAVGSTHALADRDLISYQYREHGAIVVRDL 112 >UniRef50_A0LLM4 Cluster: Pyruvate dehydrogenase; n=1; Syntrophobacter fumaroxidans MPOB|Rep: Pyruvate dehydrogenase - Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) Length = 365 Score = 50.4 bits (115), Expect = 5e-05 Identities = 27/88 (30%), Positives = 49/88 (55%) Frame = +3 Query: 330 VMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGI 509 +++ NG++ DK+ EP++ ++ L+ +Y+ MV D+ + QRQGRI + G+E Sbjct: 17 ILNENGEV-DKSLEPDIPESLLVKLYRAMVLSRKFDERMLILQRQGRIGTFAPIKGQEAQ 75 Query: 510 T*AAPRALSPKDLVFSQYREVGVFLYRG 593 A L P D + +RE+ ++RG Sbjct: 76 V-GAVALLEPGDWLVPSFREMPAEVWRG 102 >UniRef50_Q0W151 Cluster: Pyruvate dehydrogenase complex E1, transketolase alpha subunit; n=1; uncultured methanogenic archaeon RC-I|Rep: Pyruvate dehydrogenase complex E1, transketolase alpha subunit - Uncultured methanogenic archaeon RC-I Length = 359 Score = 50.0 bits (114), Expect = 6e-05 Identities = 28/92 (30%), Positives = 49/92 (53%), Gaps = 1/92 (1%) Frame = +3 Query: 324 YRVMDNNGQIIDKNE-EPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGE 500 +R++ +G NE +P L + L+ MY+ MVQ D+ + QR GR+ Y G+ Sbjct: 15 FRIVSQDGSA---NELDPGLPEDLLLKMYRLMVQARTYDEKALKLQRGGRMGTYPPIAGQ 71 Query: 501 EGIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596 E I + A++ +D + YRE+G + +G+ Sbjct: 72 EAIQIGSALAMAEEDWMVPSYREIGAMIAKGV 103 >UniRef50_A5UU15 Cluster: Pyruvate dehydrogenase; n=3; Chloroflexi (class)|Rep: Pyruvate dehydrogenase - Roseiflexus sp. RS-1 Length = 350 Score = 49.6 bits (113), Expect = 8e-05 Identities = 28/94 (29%), Positives = 47/94 (50%), Gaps = 1/94 (1%) Frame = +3 Query: 363 NEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIT*AAPRALSP 539 + + LD ATLI+ Y+ MV + ++ E + +I ++ Y GEE A AL P Sbjct: 16 SNDSGLDAATLIDYYRQMVLIRRFEEKCQEMYTRAKIGGFLHLYIGEEATAVGAIAALRP 75 Query: 540 KDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRG 641 D +F+ YR+ G + RG+ + + K+ G Sbjct: 76 DDHIFTHYRDHGHAIARGLDINALMAELFGKVTG 109 >UniRef50_Q9KG99 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) alpha subunit; n=1; Bacillus halodurans|Rep: Pyruvate dehydrogenase E1 (Lipoamide) alpha subunit - Bacillus halodurans Length = 367 Score = 49.2 bits (112), Expect = 1e-04 Identities = 27/83 (32%), Positives = 43/83 (51%) Frame = +3 Query: 321 IYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGE 500 +++V+ G+ + E LDK +++MYK M+ D+ + QRQGRI Y + G+ Sbjct: 18 LFQVLTPKGECQYEGSE-FLDKTFVLSMYKQMINCREFDEKALKLQRQGRIGTYASFKGQ 76 Query: 501 EGIT*AAPRALSPKDLVFSQYRE 569 E AL P D +F YR+ Sbjct: 77 EACQIGGALALRPTDWLFPTYRD 99 >UniRef50_A0K283 Cluster: Pyruvate dehydrogenase; n=4; Actinobacteria (class)|Rep: Pyruvate dehydrogenase - Arthrobacter sp. (strain FB24) Length = 415 Score = 48.8 bits (111), Expect = 1e-04 Identities = 29/88 (32%), Positives = 44/88 (50%) Frame = +3 Query: 378 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFS 557 LD L Y M + D+ QRQG+++ ++ G+E + RA P+D +F Sbjct: 58 LDAEKLRGFYADMAAIRRFDQEATALQRQGQLALWVPLTGQEAAQIGSGRASQPQDYIFP 117 Query: 558 QYREVGVFLYRGMTVTETCEPVLRKLRG 641 YRE GV L R + + E +LR+ RG Sbjct: 118 TYREHGVALTRNVDLAE----LLRQFRG 141 >UniRef50_UPI00005103B4 Cluster: COG1071: Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit; n=1; Brevibacterium linens BL2|Rep: COG1071: Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit - Brevibacterium linens BL2 Length = 368 Score = 48.4 bits (110), Expect = 2e-04 Identities = 25/74 (33%), Positives = 38/74 (51%) Frame = +3 Query: 387 ATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYR 566 A L +Y+ MV + + + RQGR++ Y + G+E A AL+P D +F YR Sbjct: 41 AALTGLYRQMVLVRRFEAQVTHLTRQGRLATYPSAAGQEAAEVGATTALAPNDWLFPTYR 100 Query: 567 EVGVFLYRGMTVTE 608 + L RG+ V E Sbjct: 101 DSAALLTRGVPVAE 114 >UniRef50_Q4MTG0 Cluster: Pyruvate dehydrogenase E1 component subunit alpha; n=38; Bacilli|Rep: Pyruvate dehydrogenase E1 component subunit alpha - Bacillus cereus Length = 371 Score = 48.0 bits (109), Expect = 2e-04 Identities = 23/90 (25%), Positives = 45/90 (50%) Frame = +3 Query: 327 RVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEG 506 ++++ G+++++ P L L + + MV +D+ RQGR+ FY G+E Sbjct: 27 QILNEKGEVVNEAAMPELSDDQLKELMRRMVYTRVLDQRSISLNRQGRLGFYAPTAGQEA 86 Query: 507 IT*AAPRALSPKDLVFSQYREVGVFLYRGM 596 A+ AL +D + YR+V ++ G+ Sbjct: 87 SQLASHFALEAEDFILPGYRDVPQLVWHGL 116 >UniRef50_Q8EVQ2 Cluster: Pyruvate dehydrogenase E1 component subunit alpha; n=1; Mycoplasma penetrans|Rep: Pyruvate dehydrogenase E1 component subunit alpha - Mycoplasma penetrans Length = 359 Score = 47.6 bits (108), Expect = 3e-04 Identities = 26/91 (28%), Positives = 43/91 (47%) Frame = +3 Query: 324 YRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 503 Y V+D +G + L + Y TMV MD+ + + QRQG++ + N GEE Sbjct: 13 YSVLDIDGNVTQVGYRIPLSNEEIEKAYYTMVLTRRMDEKMIKWQRQGKMLTFPPNMGEE 72 Query: 504 GIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596 + A ++ +D +R VFL+ G+ Sbjct: 73 ALQVATSISMDKQDWFAPAFRSAAVFLHSGV 103 >UniRef50_P09060 Cluster: 2-oxoisovalerate dehydrogenase subunit alpha; n=68; Proteobacteria|Rep: 2-oxoisovalerate dehydrogenase subunit alpha - Pseudomonas putida Length = 410 Score = 47.6 bits (108), Expect = 3e-04 Identities = 28/96 (29%), Positives = 48/96 (50%) Frame = +3 Query: 321 IYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGE 500 + RV+D G E ++D L + M++ D + +QRQ ++SFYM + GE Sbjct: 54 LVRVLDEQGDAQGPWAE-DIDPQILRQGMRAMLKTRIFDSRMVVAQRQKKMSFYMQSLGE 112 Query: 501 EGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608 E I AL+ D+ F YR+ + + R +++ E Sbjct: 113 EAIGSGQALALNRTDMCFPTYRQQSILMARDVSLVE 148 >UniRef50_A0JUQ5 Cluster: Pyruvate dehydrogenase; n=4; Actinobacteria (class)|Rep: Pyruvate dehydrogenase - Arthrobacter sp. (strain FB24) Length = 392 Score = 47.2 bits (107), Expect = 4e-04 Identities = 29/98 (29%), Positives = 46/98 (46%) Frame = +3 Query: 399 NMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGV 578 ++Y+ MV + +D QRQG + + G+E + R+L D VFS YRE GV Sbjct: 60 SLYEDMVVIRRIDTEATALQRQGELGLWPPLLGQEASQIGSARSLRDDDFVFSSYRENGV 119 Query: 579 FLYRGMTVTETCEPVLRKLRGSGERETDAGPLRKQAPQ 692 RG+ + + +L+ RG+ D + PQ Sbjct: 120 AYCRGVDLAD----ILKVWRGNASAGWDPYTINMATPQ 153 >UniRef50_Q6L1L8 Cluster: Pyruvate dehydrogenase E1 component alpha subunit; n=2; Thermoplasmatales|Rep: Pyruvate dehydrogenase E1 component alpha subunit - Picrophilus torridus Length = 333 Score = 46.4 bits (105), Expect = 7e-04 Identities = 23/69 (33%), Positives = 36/69 (52%) Frame = +3 Query: 369 EPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDL 548 E ++ K +I+ Y+ MV +DK L RQG + FY+ N G E + A A+ D Sbjct: 3 EEDISKEDIISAYRNMVLERFLDKKLLGINRQGFLPFYIPNIGHEALHAAIGMAIRDDDF 62 Query: 549 VFSQYREVG 575 + YR++G Sbjct: 63 FYPYYRDLG 71 >UniRef50_Q1LFS5 Cluster: Dehydrogenase, E1 component; n=22; Proteobacteria|Rep: Dehydrogenase, E1 component - Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) Length = 367 Score = 46.0 bits (104), Expect = 0.001 Identities = 28/90 (31%), Positives = 44/90 (48%), Gaps = 5/90 (5%) Frame = +3 Query: 357 DKNEEPNL-----DKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AA 521 D + EP+L D ATL+ +Y+ MV D QR G+I + + G+E I Sbjct: 18 DGSPEPDLPDFARDPATLLPLYRAMVLTRQFDLKAIAMQRTGQIGTFASALGQEAIGVGV 77 Query: 522 PRALSPKDLVFSQYREVGVFLYRGMTVTET 611 A+ D++ YR+ RG+T+TE+ Sbjct: 78 ATAMRRDDVLVPSYRDHAAQFVRGVTMTES 107 >UniRef50_Q2J998 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp. CcI3|Rep: Pyruvate dehydrogenase - Frankia sp. (strain CcI3) Length = 417 Score = 44.8 bits (101), Expect = 0.002 Identities = 30/106 (28%), Positives = 49/106 (46%), Gaps = 1/106 (0%) Frame = +3 Query: 327 RVMDNNGQII-DKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 503 R++ +G ++ D D + Y +MV +D+ QRQG + ++ G+E Sbjct: 52 RLLAPDGSLVADSRFSVLADHELRMEFYTSMVLARRLDEEATALQRQGELVLWIPLRGQE 111 Query: 504 GIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRG 641 + A P+D +F YRE V +RG+ E V+R LRG Sbjct: 112 AAQVGSAAAARPRDYLFPSYREHAVAWHRGVPAVE----VIRLLRG 153 >UniRef50_Q3W421 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp. EAN1pec|Rep: Pyruvate dehydrogenase - Frankia sp. EAN1pec Length = 358 Score = 44.8 bits (101), Expect = 0.002 Identities = 30/106 (28%), Positives = 48/106 (45%), Gaps = 1/106 (0%) Frame = +3 Query: 327 RVMDNNGQIIDKNE-EPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 503 R++ +G ++D D + Y+ MV+ +D+ QRQG + ++ G+E Sbjct: 19 RLLAPDGTLVDDPRFTVRADSRQTESFYREMVRARRLDEEATALQRQGELVLWIPLRGQE 78 Query: 504 GIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRG 641 + A P D +F YRE V +RG+ E LR LRG Sbjct: 79 AAQVGSAAAAEPADFLFPSYREHAVVWHRGIPPVE----ALRLLRG 120 >UniRef50_O48615 Cluster: Alpha-keto acid dehydrogenase-like protein; n=21; Eukaryota|Rep: Alpha-keto acid dehydrogenase-like protein - Hordeum vulgare (Barley) Length = 64 Score = 44.8 bits (101), Expect = 0.002 Identities = 19/35 (54%), Positives = 24/35 (68%) Frame = +1 Query: 604 RKLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708 ++ NQ +GN D GKGRQMP+HYGS N+ T S Sbjct: 27 QEFANQLFGNNLDYGKGRQMPIHYGSNRLNLFTRS 61 Score = 36.3 bits (80), Expect = 0.79 Identities = 16/27 (59%), Positives = 20/27 (74%) Frame = +3 Query: 528 ALSPKDLVFSQYREVGVFLYRGMTVTE 608 ALS +D+V QYRE GV L+RG T+ E Sbjct: 2 ALSAQDIVLPQYREPGVLLWRGFTLQE 28 >UniRef50_Q1AZ54 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacter xylanophilus DSM 9941|Rep: Pyruvate dehydrogenase - Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129) Length = 325 Score = 44.4 bits (100), Expect = 0.003 Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 1/116 (0%) Frame = +3 Query: 354 IDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRIS-FYMTNYGEEGIT*AAPRA 530 +++ E P ++ L++ Y+ MV+ ++ L +G+IS FY G+EG A A Sbjct: 1 MEEREMPERER--LLDFYERMVRCMLWEQKLLRFIDEGKISGFYHAGRGQEGTQVGAVAA 58 Query: 531 LSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRGSGERETDAGPLRKQAPQHG 698 L P D + +R G + RGM +++ L GS R AG + PQ G Sbjct: 59 LGPDDYMMYAHRGCGYMVARGMPMSKLFGDFLANTEGS-TRGLGAGIVHIAWPQLG 113 >UniRef50_Q9RYC1 Cluster: 2-oxo acid dehydrogenase, E1 component, alpha subunit; n=2; Deinococcus|Rep: 2-oxo acid dehydrogenase, E1 component, alpha subunit - Deinococcus radiodurans Length = 381 Score = 43.6 bits (98), Expect = 0.005 Identities = 20/43 (46%), Positives = 29/43 (67%) Frame = +1 Query: 610 LVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS*SIREHKLPP 738 L++QC G+ D +GRQMP H+ S+ HN V+ S SI ++PP Sbjct: 118 LISQCLGSNTDECRGRQMPHHFSSRAHNFVSASSSIAS-QVPP 159 >UniRef50_A3RZM3 Cluster: Pyruvate dehydrogenase E1 component alpha subunit; n=5; Proteobacteria|Rep: Pyruvate dehydrogenase E1 component alpha subunit - Ralstonia solanacearum UW551 Length = 368 Score = 43.6 bits (98), Expect = 0.005 Identities = 21/74 (28%), Positives = 39/74 (52%) Frame = +3 Query: 390 TLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYRE 569 TL+ +Y+ MV D QR G++ + ++ G+E I A+ +D++F YR+ Sbjct: 34 TLLALYRAMVLTRAFDTKAIALQRTGKLGTFASSVGQEAIGVGVASAMRAEDVLFPSYRD 93 Query: 570 VGVFLYRGMTVTET 611 L RG+++ E+ Sbjct: 94 HSAQLLRGVSMAES 107 >UniRef50_P37940 Cluster: 2-oxoisovalerate dehydrogenase subunit alpha; n=37; Firmicutes|Rep: 2-oxoisovalerate dehydrogenase subunit alpha - Bacillus subtilis Length = 330 Score = 43.6 bits (98), Expect = 0.005 Identities = 25/85 (29%), Positives = 45/85 (52%), Gaps = 1/85 (1%) Frame = +3 Query: 357 DKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALS 536 ++++ L ++MY+TM+ +D+ ++ R G+I F ++ G+E A AL Sbjct: 4 NRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPFVISCQGQEAAQVGAAFALD 63 Query: 537 PK-DLVFSQYREVGVFLYRGMTVTE 608 + D V YR++GV L GMT + Sbjct: 64 REMDYVLPYYRDMGVVLAFGMTAKD 88 >UniRef50_Q5SJR9 Cluster: Pyruvate dehydrogenase (Lipoamide) (EC 1.2.4.1) E1-alpha chain; n=2; Thermus thermophilus|Rep: Pyruvate dehydrogenase (Lipoamide) (EC 1.2.4.1) E1-alpha chain - Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) Length = 346 Score = 42.7 bits (96), Expect = 0.009 Identities = 24/83 (28%), Positives = 39/83 (46%) Frame = +3 Query: 354 IDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRAL 533 +D+ E P ++ L +Y+ M + D+ QRQGR+ Y G+E AL Sbjct: 9 LDEGEFPLAEEEAL-RLYRAMRRARFFDEKALTLQRQGRLGVYAPFMGQEAAQVGVALAL 67 Query: 534 SPKDLVFSQYREVGVFLYRGMTV 602 +D V YRE + L +G+ + Sbjct: 68 EERDWVVPSYRESAMLLAKGLPI 90 >UniRef50_A6GB57 Cluster: Pyruvate dehydrogenase; n=1; Plesiocystis pacifica SIR-1|Rep: Pyruvate dehydrogenase - Plesiocystis pacifica SIR-1 Length = 308 Score = 42.7 bits (96), Expect = 0.009 Identities = 36/137 (26%), Positives = 60/137 (43%) Frame = +3 Query: 300 TSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISF 479 T++EP + ++D+ G + D LD L + YK +V +D L + + Sbjct: 4 TAWEPEGVEALLDSKGALADPAAVSGLD---LRSFYKQLVAARILDLKLGRLE----LPM 56 Query: 480 YMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRGSGERET 659 + GEE ++ A + +D VF R+ V L RG+ +TE +LR+L G ET Sbjct: 57 WAPAAGEEAVSVAVGSLVGEEDWVFVGNRDAAVALTRGLPLTE----ILRQLLGQASAET 112 Query: 660 DAGPLRKQAPQHGHNIL 710 L H ++ Sbjct: 113 RGRGLPGSLSSREHKLM 129 >UniRef50_A0M1U4 Cluster: 2-oxoisovalerate dehydrogenase E1 component subunits alpha and beta; n=18; Bacteroidetes|Rep: 2-oxoisovalerate dehydrogenase E1 component subunits alpha and beta - Gramella forsetii (strain KT0803) Length = 685 Score = 42.7 bits (96), Expect = 0.009 Identities = 23/102 (22%), Positives = 53/102 (51%), Gaps = 1/102 (0%) Frame = +3 Query: 288 FFNETSYEPIPIYRVMDNNGQIIDKN-EEPNLDKATLINMYKTMVQLSHMDKILYESQRQ 464 FF+ + Y ++ NN + +E L ++++Y++M++ +++ + RQ Sbjct: 4 FFSLECFTDKQNYFMLSNNTKSRTMEYKETQLSNDAMLDLYRSMLKPRMIEEKMLILLRQ 63 Query: 465 GRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYR 590 G+IS + + G+E I+ ++L ++ + +R +GVF R Sbjct: 64 GKISKWFSGIGQEAISVGVTKSLETEEYILPMHRNLGVFTSR 105 >UniRef50_Q749T8 Cluster: Pyruvate dehydrogenase complex E1 component, alpha subunit; n=4; Geobacter|Rep: Pyruvate dehydrogenase complex E1 component, alpha subunit - Geobacter sulfurreducens Length = 352 Score = 42.3 bits (95), Expect = 0.012 Identities = 25/77 (32%), Positives = 36/77 (46%) Frame = +3 Query: 372 PNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLV 551 P+L L ++ M+ D+ QR+GRI Y + G+E + AL P D V Sbjct: 29 PDLSGDQLRRLHYLMLLTRTFDRRALALQREGRIGTYPSVLGQEAAQVGSAFALQPSDWV 88 Query: 552 FSQYREVGVFLYRGMTV 602 F +RE+G L G V Sbjct: 89 FPSFREMGAHLTLGYPV 105 >UniRef50_Q49108 Cluster: Pyruvate dehydrogenase EI alpha subunit; n=5; Mollicutes|Rep: Pyruvate dehydrogenase EI alpha subunit - Mycoplasma capricolum Length = 370 Score = 42.3 bits (95), Expect = 0.012 Identities = 27/92 (29%), Positives = 43/92 (46%), Gaps = 1/92 (1%) Frame = +3 Query: 330 VMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGI 509 V+D +G++I+ P + ++ YK M D QRQGR+ ++++ G+E Sbjct: 17 VLDKDGKVINPKLMPKISDQEILEAYKIMNLSRRQDIYQNTMQRQGRLLSFLSSTGQEAC 76 Query: 510 T*AAPRALSPK-DLVFSQYREVGVFLYRGMTV 602 A AL+ K D S YR +L G V Sbjct: 77 EVAYINALNKKTDHFVSGYRNNAAWLAMGQLV 108 >UniRef50_Q12FH4 Cluster: Pyruvate dehydrogenase; n=37; Bacteria|Rep: Pyruvate dehydrogenase - Polaromonas sp. (strain JS666 / ATCC BAA-500) Length = 337 Score = 42.3 bits (95), Expect = 0.012 Identities = 33/120 (27%), Positives = 57/120 (47%), Gaps = 2/120 (1%) Frame = +3 Query: 381 DKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIT*AAPRALSPKDLVFS 557 DKA + + M+++ M++ + + +I ++ Y GEE + A RAL P+D V + Sbjct: 17 DKAFALAVLAGMLRIRRMEEKCAQLYGEQKIRGFLHLYIGEEAVAVGALRALQPQDNVVA 76 Query: 558 QYREVGVFLYRGMTVTETCEPVLRKLRGSGERETDAGPLRKQAPQ-HGHNILVH*GTQIA 734 YRE G L RG+ + + K G + L +A + +G N +V G +A Sbjct: 77 TYREHGHALLRGLAMNGIMAEMYGKREGCSRGRGGSMHLFDRATRFYGGNAIVGGGLPLA 136 >UniRef50_A5IXN2 Cluster: Pyruvate dehydrogenase E1 component, alphasubunit; n=1; Mycoplasma agalactiae|Rep: Pyruvate dehydrogenase E1 component, alphasubunit - Mycoplasma agalactiae Length = 363 Score = 41.1 bits (92), Expect = 0.028 Identities = 25/98 (25%), Positives = 44/98 (44%) Frame = +3 Query: 309 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 488 +P R +D +G++I + + K L+ MYK M++ D Q+ GR+ + Sbjct: 14 DPNETVRFLDVDGKLIQEFKPSAETKKKLVEMYKNMIRSRQWDLYSLTLQKTGRLGTFAP 73 Query: 489 NYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTV 602 GEE L+ +D YR + L RG+++ Sbjct: 74 ALGEEAALTGIGFNLNKEDWFIPHYRVLPTQLARGISM 111 >UniRef50_Q53610 Cluster: Branched-chain alpha-keto acid dehydrogenase E1-alpha subunit; n=16; Actinomycetales|Rep: Branched-chain alpha-keto acid dehydrogenase E1-alpha subunit - Streptomyces avermitilis Length = 406 Score = 40.3 bits (90), Expect = 0.049 Identities = 24/71 (33%), Positives = 32/71 (45%) Frame = +3 Query: 393 LINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREV 572 L +Y+ MV D QRQG + + + G+E + RA D VF YRE Sbjct: 70 LRGLYRDMVLSRRFDAEATSLQRQGELGLWASMLGQEAAQIGSGRATRDDDYVFPTYREH 129 Query: 573 GVFLYRGMTVT 605 GV RG+ T Sbjct: 130 GVAWCRGVDPT 140 >UniRef50_A0JY23 Cluster: Pyruvate dehydrogenase; n=2; Arthrobacter|Rep: Pyruvate dehydrogenase - Arthrobacter sp. (strain FB24) Length = 359 Score = 40.3 bits (90), Expect = 0.049 Identities = 24/68 (35%), Positives = 33/68 (48%), Gaps = 1/68 (1%) Frame = +3 Query: 378 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRAL-SPKDLVF 554 L L +Y MV + H+D QRQG I Y G+E + A+ + +D VF Sbjct: 30 LTAGQLRELYSLMVAVRHLDTSAIAWQRQGLIPGYAPELGQEAAQVGSGYAVDTARDFVF 89 Query: 555 SQYREVGV 578 YRE+GV Sbjct: 90 PTYREMGV 97 >UniRef50_Q8D6Q7 Cluster: Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component, eukaryotic type, alpha subunit; n=4; Vibrionaceae|Rep: Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component, eukaryotic type, alpha subunit - Vibrio vulnificus Length = 364 Score = 39.9 bits (89), Expect = 0.064 Identities = 23/97 (23%), Positives = 44/97 (45%), Gaps = 1/97 (1%) Frame = +3 Query: 309 EPIPIYRVMDNNGQIIDKNEEPN-LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYM 485 + +P++R +D G + ++ P+ + L+ Y+ M+ D QR G++ Y Sbjct: 4 QALPMHRFLDYEGNV--QSPLPSWASEERLVQFYRDMLITRAYDNKAVALQRTGKLGTYP 61 Query: 486 TNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596 ++ G E AL P D+ YR++ RG+ Sbjct: 62 SHLGSEAFGVGIGHALKPSDVFIPYYRDMPAMWVRGI 98 >UniRef50_Q83DQ6 Cluster: Dehydrogenase, E1 component, alpha subunit; n=3; Coxiella burnetii|Rep: Dehydrogenase, E1 component, alpha subunit - Coxiella burnetii Length = 368 Score = 39.9 bits (89), Expect = 0.064 Identities = 22/93 (23%), Positives = 41/93 (44%), Gaps = 6/93 (6%) Frame = +3 Query: 348 QIIDKNEEPN------LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGI 509 Q +D N P D L+ +Y+ M + +D QR G++ Y ++ G+E + Sbjct: 17 QFLDANSNPTQPFPDFADPDMLLYLYRRMALIRQLDNKAINLQRTGKMGTYPSSRGQEAV 76 Query: 510 T*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608 A+ +D+ YR+ G G+ ++E Sbjct: 77 GIGMGSAMQKEDIFCPYYRDQGALFEHGIKLSE 109 >UniRef50_Q83FF2 Cluster: Pyruvate dehydrogenase E1 component alpha subunit; n=2; Tropheryma whipplei|Rep: Pyruvate dehydrogenase E1 component alpha subunit - Tropheryma whipplei (strain Twist) (Whipple's bacillus) Length = 370 Score = 39.5 bits (88), Expect = 0.085 Identities = 23/96 (23%), Positives = 44/96 (45%) Frame = +3 Query: 375 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVF 554 +LD + Y+ ++ + +D QR+G ++ + YG+E A A S D++F Sbjct: 33 SLDVEDIQRFYRDIILVRQIDHEAALLQRRGELALWPPVYGQEASQIGATYACSENDMIF 92 Query: 555 SQYREVGVFLYRGMTVTETCEPVLRKLRGSGERETD 662 YR+ V RG+ + + + RG+ + D Sbjct: 93 PSYRDHAVMHARGIDLVH----IAKLFRGASNNDWD 124 >UniRef50_A6WG12 Cluster: Pyruvate dehydrogenase; n=3; Actinomycetales|Rep: Pyruvate dehydrogenase - Kineococcus radiotolerans SRS30216 Length = 390 Score = 39.5 bits (88), Expect = 0.085 Identities = 23/76 (30%), Positives = 38/76 (50%) Frame = +3 Query: 369 EPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDL 548 E +L+ L+ + + MV L +D QRQG++ + + G+E + A +D Sbjct: 39 EVDLEPEELLALLRDMVLLRRLDAEGEALQRQGQLGLWPGSRGQEAAQVGSATACRRQDQ 98 Query: 549 VFSQYREVGVFLYRGM 596 VF YR+ G L RG+ Sbjct: 99 VFPSYRDHGAVLGRGI 114 >UniRef50_Q72GU1 Cluster: 2-oxoisovalerate dehydrogenase subunit alpha; n=2; Thermus thermophilus|Rep: 2-oxoisovalerate dehydrogenase subunit alpha - Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) Length = 367 Score = 39.5 bits (88), Expect = 0.085 Identities = 20/45 (44%), Positives = 25/45 (55%) Frame = +1 Query: 604 RKLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS*SIREHKLPP 738 ++L Q DP KGRQMP H GSK N T++ I H +PP Sbjct: 109 KELFGQMLATKADPNKGRQMPEHPGSKALNFFTVASPIASH-VPP 152 >UniRef50_Q5LVW0 Cluster: Dehydrogenase/transketolase family protein; n=23; Proteobacteria|Rep: Dehydrogenase/transketolase family protein - Silicibacter pomeroyi Length = 740 Score = 38.7 bits (86), Expect = 0.15 Identities = 21/77 (27%), Positives = 38/77 (49%) Frame = +3 Query: 372 PNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLV 551 P L +A +++Y+ V +D+ Q+ G+ + + + G EG+ A +AL P D+ Sbjct: 38 PGLTQAQAVSLYRAQVLSRALDRTSRAMQKAGQGFYTIGSSGHEGMA-AVAQALRPTDIA 96 Query: 552 FSQYREVGVFLYRGMTV 602 F YR+ + R V Sbjct: 97 FLHYRDAAFQIARAEQV 113 >UniRef50_Q9RPS5 Cluster: TPP-dependent branched-chain alpha-keto acid dehydrogenase, E1 alpha subunit; n=3; Lactobacillales|Rep: TPP-dependent branched-chain alpha-keto acid dehydrogenase, E1 alpha subunit - Enterococcus faecalis (Streptococcus faecalis) Length = 330 Score = 38.3 bits (85), Expect = 0.20 Identities = 17/29 (58%), Positives = 20/29 (68%), Gaps = 1/29 (3%) Frame = +1 Query: 625 YGNCEDPGK-GRQMPVHYGSKHHNMVTIS 708 +G DP GRQMP HYGSK HN+V+ S Sbjct: 94 FGKEADPSSHGRQMPNHYGSKEHNIVSFS 122 >UniRef50_Q7N5R1 Cluster: Similar to 3-methyl-2-oxobutanoate dehydrogenase; n=1; Photorhabdus luminescens subsp. laumondii|Rep: Similar to 3-methyl-2-oxobutanoate dehydrogenase - Photorhabdus luminescens subsp. laumondii Length = 665 Score = 37.9 bits (84), Expect = 0.26 Identities = 18/58 (31%), Positives = 32/58 (55%) Frame = +3 Query: 459 RQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRK 632 RQGR F+++ G EG+ P+ + D++ YR+ + L RGM++ E ++ K Sbjct: 46 RQGRAWFHVSAAGHEGLA-VLPQLMEKNDVLVPYYRDRALVLARGMSIVEMTRELMGK 102 >UniRef50_Q3DYK5 Cluster: Dehydrogenase, E1 component; n=3; Bacteria|Rep: Dehydrogenase, E1 component - Chloroflexus aurantiacus J-10-fl Length = 321 Score = 37.9 bits (84), Expect = 0.26 Identities = 14/40 (35%), Positives = 26/40 (65%) Frame = +3 Query: 480 YMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMT 599 Y + G E ++ AA +L P+D++ +R++G +L RG+T Sbjct: 39 YFSQIGHEALSVAAALSLGPRDIIAPMHRDLGAYLVRGLT 78 >UniRef50_Q1IY28 Cluster: Pyruvate dehydrogenase; n=1; Deinococcus geothermalis DSM 11300|Rep: Pyruvate dehydrogenase - Deinococcus geothermalis (strain DSM 11300) Length = 361 Score = 37.9 bits (84), Expect = 0.26 Identities = 21/77 (27%), Positives = 35/77 (45%) Frame = +3 Query: 381 DKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQ 560 D T + +Y+ M + H D+ + R GR+ + G E AL+ D +F Sbjct: 36 DVPTRLKLYRLMRRARHFDERAWVLYRTGRMGVFPPYGGMEASQVGTAAALTHADWLFPT 95 Query: 561 YREVGVFLYRGMTVTET 611 YR+ G L G+ + +T Sbjct: 96 YRDTGAALTYGLPLEQT 112 >UniRef50_Q67SE7 Cluster: Pyruvate dehydrogenase E1 alpha subunit; n=2; Bacilli|Rep: Pyruvate dehydrogenase E1 alpha subunit - Symbiobacterium thermophilum Length = 368 Score = 37.5 bits (83), Expect = 0.34 Identities = 27/110 (24%), Positives = 49/110 (44%), Gaps = 1/110 (0%) Frame = +3 Query: 318 PIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYG 497 P+ R++ +G +++ L L ++Y+ MV L D+ QRQGR+ + G Sbjct: 15 PVRRILQADGTLLEP-VPAFLSVDQLKDVYRKMVYLRVFDQRCLNLQRQGRMGTFAPFSG 73 Query: 498 EEGIT*AAPRALSP-KDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRGS 644 +E + L P +D +F YR+ G G+ + + +GS Sbjct: 74 QEASQVGSAYLLRPDRDWIFPTYRDHGAMHVMGVPLVNILRYFMGDEQGS 123 >UniRef50_P16387 Cluster: Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial precursor; n=34; Dikarya|Rep: Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial precursor - Saccharomyces cerevisiae (Baker's yeast) Length = 420 Score = 37.5 bits (83), Expect = 0.34 Identities = 36/120 (30%), Positives = 55/120 (45%), Gaps = 4/120 (3%) Frame = +3 Query: 384 KATLINMYKTMVQLSHMDKILYESQRQGRI-SFYMTNYGEEGIT*AAPRALSPKDLVFSQ 560 KATL+ MYK MV + M+ + +I F + G+E I A++ D + + Sbjct: 78 KATLLQMYKDMVIIRRMEMACDALYKAKKIRGFCHLSVGQEAIAVGIENAITKLDSIITS 137 Query: 561 YREVGVFLYRGMTVTETCEPVLRKLRG--SGERETDAGPLRKQAPQ-HGHNILVH*GTQI 731 YR G RG +V + VL +L G +G G + AP +G N +V G Q+ Sbjct: 138 YRCHGFTFMRGASV----KAVLAELMGRRAGVSYGKGGSMHLYAPGFYGGNGIV--GAQV 191 >UniRef50_Q6A611 Cluster: Pyruvate dehydrogenase E1 component, alpha subunit; n=1; Propionibacterium acnes|Rep: Pyruvate dehydrogenase E1 component, alpha subunit - Propionibacterium acnes Length = 381 Score = 37.1 bits (82), Expect = 0.45 Identities = 29/119 (24%), Positives = 50/119 (42%), Gaps = 1/119 (0%) Frame = +3 Query: 255 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEP-NLDKATLINMYKTMVQLSH 431 G P+V + +P + R++D G++ + P +L L+ + MV Sbjct: 10 GGTDPFVLPARQHPVNRPDPAMV-RILDEQGRLTTHPDFPVDLVDDDLVKALEMMVMTRR 68 Query: 432 MDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608 +D QR G + + G+E A AL D VF YRE G+ G+++ + Sbjct: 69 LDVEATALQRHGELGLWPPLLGQEATQAGAWLALREGDQVFPTYREQGLAHAMGVSLAD 127 >UniRef50_A4F1Y5 Cluster: Branched-chain alpha-keto acid decarboxylase; n=1; Streptomyces virginiae|Rep: Branched-chain alpha-keto acid decarboxylase - Streptomyces virginiae Length = 677 Score = 37.1 bits (82), Expect = 0.45 Identities = 19/58 (32%), Positives = 31/58 (53%) Frame = +3 Query: 459 RQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRK 632 RQG+ F++++ G E + A L P+DL+F YR+ + L RGM ++ K Sbjct: 57 RQGQAWFHISSAGHEALA-ALCELLEPEDLIFPHYRDRTLMLARGMDAEGQARDLMAK 113 >UniRef50_Q1EGI2 Cluster: Pyruvate dehydrogenase E1 alpha subunit; n=6; Spirotrichea|Rep: Pyruvate dehydrogenase E1 alpha subunit - Euplotes sp. BB-2004 Length = 389 Score = 35.5 bits (78), Expect = 1.4 Identities = 31/125 (24%), Positives = 58/125 (46%), Gaps = 4/125 (3%) Frame = +3 Query: 288 FFNETSYEPIPIYRVMDNNGQIIDKNEEPN---LDKATLINMYKTMVQLSHMDKILYESQ 458 FF+ T +P ++V I+++E P K+ L+N YK M + ++ + Sbjct: 22 FFSSTIEVELPKFKV-----HRIEESELPTKATTTKSELLNYYKDMALMRRVEIVSDMLY 76 Query: 459 RQGRISFYMTNY-GEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKL 635 + I + Y G+E IT AL+ +D + + YR+ + RG T E ++++ Sbjct: 77 KNKWIRGFCHLYDGQESITVGMEAALTMEDHIINAYRDHTTAMGRGHTSYEIIAEMMQRS 136 Query: 636 RGSGE 650 GS + Sbjct: 137 TGSSK 141 >UniRef50_Q9HNV6 Cluster: Pyruvate dehydrogenase alpha subunit; n=1; Halobacterium salinarum|Rep: Pyruvate dehydrogenase alpha subunit - Halobacterium salinarium (Halobacterium halobium) Length = 322 Score = 35.5 bits (78), Expect = 1.4 Identities = 21/65 (32%), Positives = 32/65 (49%) Frame = +3 Query: 414 MVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRG 593 MV+ H D+ QR+G + Y G+EG A AL+ D +F YR + L RG Sbjct: 1 MVRARHFDERALALQRRGWMPGYPPFKGQEGSQVGAAHALAGDDWLFPTYRSNAMQLARG 60 Query: 594 MTVTE 608 + ++ Sbjct: 61 VPASD 65 >UniRef50_Q74AD3 Cluster: Dehydrogenase complex, E1 component, alpha subunit; n=5; Geobacter|Rep: Dehydrogenase complex, E1 component, alpha subunit - Geobacter sulfurreducens Length = 325 Score = 35.1 bits (77), Expect = 1.8 Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 1/73 (1%) Frame = +3 Query: 378 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIT*AAPRALSPKDLVF 554 L + L+ M++ MV ++ E +G I+ ++ Y G+E + A AL D + Sbjct: 9 LPDSELLKMHEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAALRKDDYIL 68 Query: 555 SQYREVGVFLYRG 593 S YRE + RG Sbjct: 69 SAYREHAQAIVRG 81 >UniRef50_Q2BFQ9 Cluster: Putative uncharacterized protein; n=1; Bacillus sp. NRRL B-14911|Rep: Putative uncharacterized protein - Bacillus sp. NRRL B-14911 Length = 668 Score = 35.1 bits (77), Expect = 1.8 Identities = 22/89 (24%), Positives = 45/89 (50%), Gaps = 1/89 (1%) Frame = +3 Query: 378 LDKATLINMYKTMVQLSHMDKILYESQRQGRI-SFYMTNYGEEGIT*AAPRALSPKDLVF 554 L + T+ +MYK M+ + +++ L + +G + T+ G+E A+ + D+VF Sbjct: 14 LSQETIDSMYKKMITIRTLEETLLDLFSKGELFGTTHTSIGQEANAVASMAHIKNGDVVF 73 Query: 555 SQYREVGVFLYRGMTVTETCEPVLRKLRG 641 S +R G ++ G V + V+ ++ G Sbjct: 74 SNHRCHGHYIAYGAPVDQLIAEVMGRVTG 102 >UniRef50_Q67ME6 Cluster: Branched-chain alpha-keto acid dehydrogenase E1 alpha subunit; n=23; Bacteria|Rep: Branched-chain alpha-keto acid dehydrogenase E1 alpha subunit - Symbiobacterium thermophilum Length = 352 Score = 34.7 bits (76), Expect = 2.4 Identities = 32/116 (27%), Positives = 49/116 (42%), Gaps = 1/116 (0%) Frame = +3 Query: 360 KNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSP 539 ++E L + MY M+ +D+ L+ QR G+I F ++ G+E A A Sbjct: 26 RHEALGLTADQVREMYYYMLLTRRLDERLWLLQRGGKIPFVISPQGQEAAQVGAAFAFRR 85 Query: 540 K-DLVFSQYREVGVFLYRGMTVTETCEPVLRKLRGSGERETDAGPLRKQAPQHGHN 704 + D YR++GV L G+T E + + R D KQ P H N Sbjct: 86 RQDWFTPYYRDLGVNLVVGVTPREV-------MLSAFARGADPASGGKQMPSHWGN 134 >UniRef50_Q479Q2 Cluster: Dehydrogenase, E1 component; n=2; Rhodocyclaceae|Rep: Dehydrogenase, E1 component - Dechloromonas aromatica (strain RCB) Length = 320 Score = 34.7 bits (76), Expect = 2.4 Identities = 17/66 (25%), Positives = 30/66 (45%) Frame = +3 Query: 396 INMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVG 575 + +Y+ ++ + + + GRI T+ G+E A AL DL+ + +R G Sbjct: 11 LRLYEQLLLIRAYENAIVRGSTDGRIPGTCTSVGQEAAAVGAINALEADDLILTNHRSAG 70 Query: 576 VFLYRG 593 L RG Sbjct: 71 HLLARG 76 >UniRef50_Q02C52 Cluster: Pyruvate dehydrogenase; n=1; Solibacter usitatus Ellin6076|Rep: Pyruvate dehydrogenase - Solibacter usitatus (strain Ellin6076) Length = 340 Score = 34.7 bits (76), Expect = 2.4 Identities = 20/81 (24%), Positives = 38/81 (46%), Gaps = 1/81 (1%) Frame = +3 Query: 402 MYKTMVQLSHMDKILYESQRQGRI-SFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGV 578 +Y ++ D+I + RQG+I G+E I + P+D++F +R++ V Sbjct: 30 LYYMLLMREVEDRIERKLYRQGKILGGVYVGRGQEAIPVGSALVAVPEDVMFPSHRDMAV 89 Query: 579 FLYRGMTVTETCEPVLRKLRG 641 F RG++ + +L G Sbjct: 90 FFIRGVSARRVLAQYMGRLGG 110 >UniRef50_A0LSF3 Cluster: Pyruvate dehydrogenase; n=5; Bacteria|Rep: Pyruvate dehydrogenase - Acidothermus cellulolyticus (strain ATCC 43068 / 11B) Length = 375 Score = 34.7 bits (76), Expect = 2.4 Identities = 20/65 (30%), Positives = 32/65 (49%), Gaps = 1/65 (1%) Frame = +3 Query: 405 YKTMVQLSHMDKILYESQRQGRISFYM-TNYGEEGIT*AAPRALSPKDLVFSQYREVGVF 581 Y+ M + ++ E ++ +I Y N GEE A++P D +F+ YRE G Sbjct: 45 YRMMQLIRRFEERAAEMYQRAKIGGYCHLNLGEEATVVGLMDAMAPHDYLFTTYREHGYA 104 Query: 582 LYRGM 596 L RG+ Sbjct: 105 LARGI 109 >UniRef50_Q8YNY8 Cluster: Asr4421 protein; n=1; Nostoc sp. PCC 7120|Rep: Asr4421 protein - Anabaena sp. (strain PCC 7120) Length = 71 Score = 33.9 bits (74), Expect = 4.2 Identities = 16/38 (42%), Positives = 24/38 (63%) Frame = -3 Query: 185 FTIFVIDLFLTSLLLTSIACFQKSNTKVYDCTDSRKYC 72 F ++ +FL +L+TS+ +KSNT V+ T S KYC Sbjct: 26 FMVYAKSIFL-KVLMTSVYSLKKSNTYVFTVTYSGKYC 62 >UniRef50_A6DTS3 Cluster: Dehydrogenase complex, E1 component, alpha subunit; n=1; Lentisphaera araneosa HTCC2155|Rep: Dehydrogenase complex, E1 component, alpha subunit - Lentisphaera araneosa HTCC2155 Length = 320 Score = 33.9 bits (74), Expect = 4.2 Identities = 22/90 (24%), Positives = 41/90 (45%), Gaps = 1/90 (1%) Frame = +3 Query: 375 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIT*AAPRALSPKDLV 551 N+ K + M + M+++ ++ +S +Q I+ + Y G+E + A L+P D Sbjct: 3 NIGKEKALQMLEQMIRVRRFEEGCLKSYQQKFITGFCHTYIGQEAVAVGAMAHLTPTDAY 62 Query: 552 FSQYREVGVFLYRGMTVTETCEPVLRKLRG 641 + YR L G+T E + K+ G Sbjct: 63 VTSYRCHAQGLIGGLTSREVMAEMFGKITG 92 >UniRef50_Q8ZUR8 Cluster: Pyruvate dehydrogenase E1 alpha subunit; n=3; Pyrobaculum|Rep: Pyruvate dehydrogenase E1 alpha subunit - Pyrobaculum aerophilum Length = 372 Score = 33.9 bits (74), Expect = 4.2 Identities = 25/102 (24%), Positives = 45/102 (44%), Gaps = 2/102 (1%) Frame = +3 Query: 297 ETSYEPIPIYRVMDNNGQIIDKNEEP-NLDKATLINMYKTMVQLSHMDKILYESQRQGRI 473 +T + ++RV+ +G ++ E + L Y+ MV +D+ R G++ Sbjct: 13 KTEVKEPQVFRVLGQDGSPLETYEVGYKPSEGELAKAYRWMVLGRVLDRYALMYHRMGKV 72 Query: 474 -SFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596 S Y + G E AL P+D V YR + + + RG+ Sbjct: 73 KSTYGPHEGHEAADAGTALALRPEDWVAPYYRNLTLLIARGV 114 >UniRef50_Q2JA37 Cluster: Pyruvate dehydrogenase; n=11; Actinomycetales|Rep: Pyruvate dehydrogenase - Frankia sp. (strain CcI3) Length = 388 Score = 33.1 bits (72), Expect = 7.4 Identities = 16/46 (34%), Positives = 24/46 (52%) Frame = +3 Query: 459 RQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596 RQGR++ Y + G+E AA L D +F YR+ + RG+ Sbjct: 73 RQGRLAVYPASTGQEACQIAAAMVLRESDWLFPSYRDTLAVVSRGV 118 >UniRef50_A7GY08 Cluster: Ferric uptake regulation protein; n=2; Campylobacter|Rep: Ferric uptake regulation protein - Campylobacter curvus 525.92 Length = 147 Score = 33.1 bits (72), Expect = 7.4 Identities = 16/46 (34%), Positives = 27/46 (58%) Frame = -2 Query: 177 ICYRSFSHITTFDIDSLFSKIQYKSLRLH*FSKILLFIQNSTLCSS 40 I YRS +H++ DI + FSKI +++ L +L F+ LC++ Sbjct: 32 ILYRSQTHLSAQDIQTEFSKIHAQNISLPTIYALLNFLDECRLCNT 77 >UniRef50_A3S1N4 Cluster: Putative uncharacterized protein; n=1; Prochlorococcus marinus str. MIT 9211|Rep: Putative uncharacterized protein - Prochlorococcus marinus str. MIT 9211 Length = 263 Score = 33.1 bits (72), Expect = 7.4 Identities = 17/51 (33%), Positives = 26/51 (50%) Frame = -3 Query: 173 VIDLFLTSLLLTSIACFQKSNTKVYDCTDSRKYCCSYKIQLYVHPSSPSKS 21 ++DL TS LL A F+ T++ + + + CC Y I L + PS S Sbjct: 12 LLDLSKTSQLLAIKAEFEAEGTRIEELSVLSQLCCKYSIPLTLKVGGPSAS 62 >UniRef50_Q1XDM0 Cluster: Pyruvate dehydrogenase E1 component subunit alpha; n=52; cellular organisms|Rep: Pyruvate dehydrogenase E1 component subunit alpha - Porphyra yezoensis Length = 346 Score = 33.1 bits (72), Expect = 7.4 Identities = 17/66 (25%), Positives = 38/66 (57%), Gaps = 1/66 (1%) Frame = +3 Query: 375 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIT*AAPRALSPKDLV 551 NL+K+ L+ +Y+ M+ + + + + +G++ ++ Y G+E ++ + L+P D V Sbjct: 20 NLNKSNLLVLYEDMLLGRNFEDMCAQMYYKGKMFGFVHLYNGQEAVSTGVIKLLNPTDYV 79 Query: 552 FSQYRE 569 S YR+ Sbjct: 80 CSTYRD 85 >UniRef50_Q5DY55 Cluster: Putative uncharacterized protein; n=1; Vibrio fischeri ES114|Rep: Putative uncharacterized protein - Vibrio fischeri (strain ATCC 700601 / ES114) Length = 147 Score = 32.7 bits (71), Expect = 9.7 Identities = 20/52 (38%), Positives = 29/52 (55%), Gaps = 1/52 (1%) Frame = +3 Query: 342 NGQIIDKNEEPNLDKATLINMY-KTMVQLSHMDKILYESQRQGRISFYMTNY 494 N II K EE ++DK LI +Y KT L+ + K ++ S R G +S N+ Sbjct: 76 NKTIIVKKEERSVDKQKLIFLYKKTSNNLNQLAKQIHTSNRAGTLSREKMNH 127 Database: uniref50 Posted date: Oct 5, 2007 11:19 AM Number of letters in database: 575,637,011 Number of sequences in database: 1,657,284 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.279 0.0580 0.190 Matrix: BLOSUM62 Gap Penalties: Existence: 9, Extension: 2 Number of Hits to DB: 808,290,510 Number of Sequences: 1657284 Number of extensions: 17325550 Number of successful extensions: 45983 Number of sequences better than 10.0: 90 Number of HSP's better than 10.0 without gapping: 44241 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 45959 length of database: 575,637,011 effective HSP length: 99 effective length of database: 411,565,895 effective search space used: 60500186565 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 37 (14.9 bits) X3: 62 (25.0 bits) S1: 41 (21.7 bits)
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