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Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= tesV0337.Seq
         (742 letters)

Database: uniref50 
           1,657,284 sequences; 575,637,011 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q9VHB8 Cluster: CG8199-PA; n=2; Eukaryota|Rep: CG8199-P...   134   2e-30
UniRef50_P12694 Cluster: 2-oxoisovalerate dehydrogenase subunit ...   133   5e-30
UniRef50_Q295J7 Cluster: GA20891-PA; n=7; Coelomata|Rep: GA20891...   132   9e-30
UniRef50_Q4A1S8 Cluster: Putative uncharacterized protein; n=4; ...   130   3e-29
UniRef50_Q9LPL5 Cluster: Branched-chain alpha keto-acid dehydrog...   120   4e-26
UniRef50_A7RZV6 Cluster: Predicted protein; n=6; Eumetazoa|Rep: ...   120   4e-26
UniRef50_A6RV39 Cluster: Putative uncharacterized protein; n=1; ...   106   7e-22
UniRef50_Q4DB65 Cluster: 2-oxoisovalerate dehydrogenase alpha su...   100   7e-20
UniRef50_A0DAM1 Cluster: Chromosome undetermined scaffold_43, wh...    99   1e-19
UniRef50_Q4Y3F8 Cluster: Branched-chain alpha keto-acid dehydrog...    98   2e-19
UniRef50_Q4P2J0 Cluster: Putative uncharacterized protein; n=1; ...    95   1e-18
UniRef50_Q5KGR5 Cluster: Branched-chain alpha-keto acid dehydrog...    94   4e-18
UniRef50_Q1KSF2 Cluster: Mitochondrial branched-chain alpha-keto...    93   9e-18
UniRef50_Q6YPX5 Cluster: Thiamine pyrophosphate-dependent dehydr...    81   2e-14
UniRef50_Q5QUK4 Cluster: Alpha keto acid dehydrogenase complex, ...    79   1e-13
UniRef50_Q4QC52 Cluster: 2-oxoisovalerate dehydrogenase alpha su...    75   1e-12
UniRef50_Q9HN77 Cluster: Pyruvate dehydrogenase alpha subunit; n...    73   1e-11
UniRef50_A7HBV0 Cluster: 3-methyl-2-oxobutanoate dehydrogenase; ...    71   2e-11
UniRef50_Q9YBC0 Cluster: Pyruvate dehydrogenase E1 component, al...    69   1e-10
UniRef50_P35485 Cluster: Pyruvate dehydrogenase E1 component sub...    69   2e-10
UniRef50_Q4N1L6 Cluster: Branched-chain alpha keto-acid dehydrog...    67   5e-10
UniRef50_Q4L1A7 Cluster: Pyruvate dehydrogenase E1 component alp...    58   2e-07
UniRef50_Q5KUY4 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a...    58   3e-07
UniRef50_Q8CX87 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a...    57   5e-07
UniRef50_A6CP23 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a...    55   2e-06
UniRef50_P21873 Cluster: Pyruvate dehydrogenase E1 component sub...    55   2e-06
UniRef50_P47516 Cluster: Pyruvate dehydrogenase E1 component sub...    54   3e-06
UniRef50_A1UJ85 Cluster: Pyruvate dehydrogenase; n=16; Mycobacte...    54   4e-06
UniRef50_A7K3C9 Cluster: Dehydrogenase E1 component superfamily;...    54   5e-06
UniRef50_Q97CK0 Cluster: 2-oxoisovalerate dehydrogenase alpha su...    53   9e-06
UniRef50_Q835M4 Cluster: Pyruvate dehydrogenase complex E1 compo...    52   1e-05
UniRef50_A7D3P2 Cluster: Pyruvate dehydrogenase; n=1; Halorubrum...    52   2e-05
UniRef50_A0LLM4 Cluster: Pyruvate dehydrogenase; n=1; Syntrophob...    50   5e-05
UniRef50_Q0W151 Cluster: Pyruvate dehydrogenase complex E1, tran...    50   6e-05
UniRef50_A5UU15 Cluster: Pyruvate dehydrogenase; n=3; Chloroflex...    50   8e-05
UniRef50_Q9KG99 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a...    49   1e-04
UniRef50_A0K283 Cluster: Pyruvate dehydrogenase; n=4; Actinobact...    49   1e-04
UniRef50_UPI00005103B4 Cluster: COG1071: Pyruvate/2-oxoglutarate...    48   2e-04
UniRef50_Q4MTG0 Cluster: Pyruvate dehydrogenase E1 component sub...    48   2e-04
UniRef50_Q8EVQ2 Cluster: Pyruvate dehydrogenase E1 component sub...    48   3e-04
UniRef50_P09060 Cluster: 2-oxoisovalerate dehydrogenase subunit ...    48   3e-04
UniRef50_A0JUQ5 Cluster: Pyruvate dehydrogenase; n=4; Actinobact...    47   4e-04
UniRef50_Q6L1L8 Cluster: Pyruvate dehydrogenase E1 component alp...    46   7e-04
UniRef50_Q1LFS5 Cluster: Dehydrogenase, E1 component; n=22; Prot...    46   0.001
UniRef50_Q2J998 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp...    45   0.002
UniRef50_Q3W421 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp...    45   0.002
UniRef50_O48615 Cluster: Alpha-keto acid dehydrogenase-like prot...    45   0.002
UniRef50_Q1AZ54 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacte...    44   0.003
UniRef50_Q9RYC1 Cluster: 2-oxo acid dehydrogenase, E1 component,...    44   0.005
UniRef50_A3RZM3 Cluster: Pyruvate dehydrogenase E1 component alp...    44   0.005
UniRef50_P37940 Cluster: 2-oxoisovalerate dehydrogenase subunit ...    44   0.005
UniRef50_Q5SJR9 Cluster: Pyruvate dehydrogenase (Lipoamide) (EC ...    43   0.009
UniRef50_A6GB57 Cluster: Pyruvate dehydrogenase; n=1; Plesiocyst...    43   0.009
UniRef50_A0M1U4 Cluster: 2-oxoisovalerate dehydrogenase E1 compo...    43   0.009
UniRef50_Q749T8 Cluster: Pyruvate dehydrogenase complex E1 compo...    42   0.012
UniRef50_Q49108 Cluster: Pyruvate dehydrogenase EI alpha subunit...    42   0.012
UniRef50_Q12FH4 Cluster: Pyruvate dehydrogenase; n=37; Bacteria|...    42   0.012
UniRef50_A5IXN2 Cluster: Pyruvate dehydrogenase E1 component, al...    41   0.028
UniRef50_Q53610 Cluster: Branched-chain alpha-keto acid dehydrog...    40   0.049
UniRef50_A0JY23 Cluster: Pyruvate dehydrogenase; n=2; Arthrobact...    40   0.049
UniRef50_Q8D6Q7 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c...    40   0.064
UniRef50_Q83DQ6 Cluster: Dehydrogenase, E1 component, alpha subu...    40   0.064
UniRef50_Q83FF2 Cluster: Pyruvate dehydrogenase E1 component alp...    40   0.085
UniRef50_A6WG12 Cluster: Pyruvate dehydrogenase; n=3; Actinomyce...    40   0.085
UniRef50_Q72GU1 Cluster: 2-oxoisovalerate dehydrogenase subunit ...    40   0.085
UniRef50_Q5LVW0 Cluster: Dehydrogenase/transketolase family prot...    39   0.15 
UniRef50_Q9RPS5 Cluster: TPP-dependent branched-chain alpha-keto...    38   0.20 
UniRef50_Q7N5R1 Cluster: Similar to 3-methyl-2-oxobutanoate dehy...    38   0.26 
UniRef50_Q3DYK5 Cluster: Dehydrogenase, E1 component; n=3; Bacte...    38   0.26 
UniRef50_Q1IY28 Cluster: Pyruvate dehydrogenase; n=1; Deinococcu...    38   0.26 
UniRef50_Q67SE7 Cluster: Pyruvate dehydrogenase E1 alpha subunit...    38   0.34 
UniRef50_P16387 Cluster: Pyruvate dehydrogenase E1 component sub...    38   0.34 
UniRef50_Q6A611 Cluster: Pyruvate dehydrogenase E1 component, al...    37   0.45 
UniRef50_A4F1Y5 Cluster: Branched-chain alpha-keto acid decarbox...    37   0.45 
UniRef50_Q1EGI2 Cluster: Pyruvate dehydrogenase E1 alpha subunit...    36   1.4  
UniRef50_Q9HNV6 Cluster: Pyruvate dehydrogenase alpha subunit; n...    36   1.4  
UniRef50_Q74AD3 Cluster: Dehydrogenase complex, E1 component, al...    35   1.8  
UniRef50_Q2BFQ9 Cluster: Putative uncharacterized protein; n=1; ...    35   1.8  
UniRef50_Q67ME6 Cluster: Branched-chain alpha-keto acid dehydrog...    35   2.4  
UniRef50_Q479Q2 Cluster: Dehydrogenase, E1 component; n=2; Rhodo...    35   2.4  
UniRef50_Q02C52 Cluster: Pyruvate dehydrogenase; n=1; Solibacter...    35   2.4  
UniRef50_A0LSF3 Cluster: Pyruvate dehydrogenase; n=5; Bacteria|R...    35   2.4  
UniRef50_Q8YNY8 Cluster: Asr4421 protein; n=1; Nostoc sp. PCC 71...    34   4.2  
UniRef50_A6DTS3 Cluster: Dehydrogenase complex, E1 component, al...    34   4.2  
UniRef50_Q8ZUR8 Cluster: Pyruvate dehydrogenase E1 alpha subunit...    34   4.2  
UniRef50_Q2JA37 Cluster: Pyruvate dehydrogenase; n=11; Actinomyc...    33   7.4  
UniRef50_A7GY08 Cluster: Ferric uptake regulation protein; n=2; ...    33   7.4  
UniRef50_A3S1N4 Cluster: Putative uncharacterized protein; n=1; ...    33   7.4  
UniRef50_Q1XDM0 Cluster: Pyruvate dehydrogenase E1 component sub...    33   7.4  
UniRef50_Q5DY55 Cluster: Putative uncharacterized protein; n=1; ...    33   9.7  

>UniRef50_Q9VHB8 Cluster: CG8199-PA; n=2; Eukaryota|Rep: CG8199-PA -
           Drosophila melanogaster (Fruit fly)
          Length = 439

 Score =  134 bits (324), Expect = 2e-30
 Identities = 60/118 (50%), Positives = 82/118 (69%)
 Frame = +3

Query: 255 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHM 434
           GA+AP+VS++       Y PIPIYRVMD +G I D+ ++P L +  +  M++ MV L+ M
Sbjct: 48  GAKAPFVSKLNLIQPEDYAPIPIYRVMDQDGYIADETQDPQLGREVVEKMFRDMVLLNTM 107

Query: 435 DKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608
           DKILYESQRQGRISFYMTN+GEE     +  AL  +DL++ QYRE GV ++RG  + +
Sbjct: 108 DKILYESQRQGRISFYMTNFGEEASHIGSAAALEMRDLIYGQYREAGVLVWRGFRIDQ 165



 Score = 54.8 bits (126), Expect = 2e-06
 Identities = 21/34 (61%), Positives = 28/34 (82%)
 Frame = +1

Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708
           + ++QCYGN +D G+G+QMPVHYGS+  N VTIS
Sbjct: 165 QFIDQCYGNTDDLGRGKQMPVHYGSRELNFVTIS 198


>UniRef50_P12694 Cluster: 2-oxoisovalerate dehydrogenase subunit
           alpha, mitochondrial precursor; n=29; Euteleostomi|Rep:
           2-oxoisovalerate dehydrogenase subunit alpha,
           mitochondrial precursor - Homo sapiens (Human)
          Length = 445

 Score =  133 bits (321), Expect = 5e-30
 Identities = 62/112 (55%), Positives = 79/112 (70%)
 Frame = +3

Query: 255 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHM 434
           GA A ++ +++F        IPIYRVMD  GQII+ +E+P+L K  ++ +YK+M  L+ M
Sbjct: 56  GASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTM 115

Query: 435 DKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYR 590
           D+ILYESQRQGRISFYMTNYGEEG    +  AL   DLVF QYRE GV +YR
Sbjct: 116 DRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYR 167



 Score = 52.8 bits (121), Expect = 9e-06
 Identities = 22/30 (73%), Positives = 23/30 (76%)
 Frame = +1

Query: 619 QCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708
           QCYGN  D GKGRQMPVHYG K  + VTIS
Sbjct: 177 QCYGNISDLGKGRQMPVHYGCKERHFVTIS 206


>UniRef50_Q295J7 Cluster: GA20891-PA; n=7; Coelomata|Rep: GA20891-PA
           - Drosophila pseudoobscura (Fruit fly)
          Length = 439

 Score =  132 bits (319), Expect = 9e-30
 Identities = 60/118 (50%), Positives = 83/118 (70%)
 Frame = +3

Query: 255 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHM 434
           GA+AP+VS++K      Y PIPIYRVMD +G I D+ ++P L +  +  M++ M+ L+ M
Sbjct: 48  GAKAPFVSKLKLNMPEDYAPIPIYRVMDRDGFIADETQDPQLGREVVEKMFRDMLLLNTM 107

Query: 435 DKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608
           DKILYESQRQGRISFYMTN+GEE     +  AL  +DL++ QYRE GV ++RG  + +
Sbjct: 108 DKILYESQRQGRISFYMTNFGEEASHIGSAAALEMRDLIYGQYREAGVLVWRGFRIDQ 165



 Score = 54.8 bits (126), Expect = 2e-06
 Identities = 21/34 (61%), Positives = 28/34 (82%)
 Frame = +1

Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708
           + ++QCYGN +D G+G+QMPVHYGS+  N VTIS
Sbjct: 165 QFIDQCYGNVDDLGRGKQMPVHYGSRELNFVTIS 198


>UniRef50_Q4A1S8 Cluster: Putative uncharacterized protein; n=4;
           Caenorhabditis|Rep: Putative uncharacterized protein -
           Caenorhabditis elegans
          Length = 432

 Score =  130 bits (315), Expect = 3e-29
 Identities = 58/114 (50%), Positives = 82/114 (71%)
 Frame = +3

Query: 261 RAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDK 440
           +A +  +++  N      +PIYRV +  G +IDK+++PN D+ T + MYKTM QL+ MD+
Sbjct: 42  KAAFTEKLEIVNADDTPALPIYRVTNAVGDVIDKSQDPNFDEQTSLKMYKTMTQLNIMDR 101

Query: 441 ILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTV 602
           ILY+SQRQGRISFYMT++GEEG    +  AL P+DL++ QYRE GV L+RG T+
Sbjct: 102 ILYDSQRQGRISFYMTSFGEEGNHVGSAAALEPQDLIYGQYREAGVLLWRGYTM 155



 Score = 56.8 bits (131), Expect = 5e-07
 Identities = 22/32 (68%), Positives = 27/32 (84%)
 Frame = +1

Query: 613 VNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708
           +NQCYGN +D GKGRQMP+H+G+K  N VTIS
Sbjct: 159 MNQCYGNADDLGKGRQMPMHFGTKERNFVTIS 190


>UniRef50_Q9LPL5 Cluster: Branched-chain alpha keto-acid
           dehydrogenase E1-alpha subunit; n=13; Magnoliophyta|Rep:
           Branched-chain alpha keto-acid dehydrogenase E1-alpha
           subunit - Arabidopsis thaliana (Mouse-ear cress)
          Length = 472

 Score =  120 bits (289), Expect = 4e-26
 Identities = 59/118 (50%), Positives = 77/118 (65%)
 Frame = +3

Query: 255 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHM 434
           G +  Y SEMKF  E+S   IP YRV+D +G+II  ++   + +   + MY+ M  L  M
Sbjct: 84  GGKVGYTSEMKFIPESSSRRIPCYRVLDEDGRIIPDSDFIPVSEKLAVRMYEQMATLQVM 143

Query: 435 DKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608
           D I YE+QRQGRISFY+T+ GEE I  A+  ALSP D+V  QYRE GV L+RG T+ E
Sbjct: 144 DHIFYEAQRQGRISFYLTSVGEEAINIASAAALSPDDVVLPQYREPGVLLWRGFTLEE 201



 Score = 50.8 bits (116), Expect = 3e-05
 Identities = 21/34 (61%), Positives = 24/34 (70%)
 Frame = +1

Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708
           +  NQC+GN  D GKGRQMP+HYGS   N  TIS
Sbjct: 201 EFANQCFGNKADYGKGRQMPIHYGSNRLNYFTIS 234


>UniRef50_A7RZV6 Cluster: Predicted protein; n=6; Eumetazoa|Rep:
           Predicted protein - Nematostella vectensis
          Length = 444

 Score =  120 bits (289), Expect = 4e-26
 Identities = 54/98 (55%), Positives = 71/98 (72%)
 Frame = +3

Query: 315 IPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY 494
           IP+YRVMD  G+II  + +P L + T+++MYK M  L+ MD+ILYESQRQGRISFYMTNY
Sbjct: 74  IPVYRVMDRQGKIIIDSHDPKLPEGTIVDMYKKMTLLNTMDRILYESQRQGRISFYMTNY 133

Query: 495 GEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608
           GEE     +  AL  +DL+  QYRE GV ++RG T+ +
Sbjct: 134 GEEATHFGSAAALEMEDLIMGQYREAGVLMWRGFTLAD 171



 Score = 56.0 bits (129), Expect = 9e-07
 Identities = 24/32 (75%), Positives = 25/32 (78%)
 Frame = +1

Query: 613 VNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708
           +NQCY N  D GKGRQMPVHYGSK  N VTIS
Sbjct: 173 MNQCYANQHDAGKGRQMPVHYGSKELNFVTIS 204


>UniRef50_A6RV39 Cluster: Putative uncharacterized protein; n=1;
           Botryotinia fuckeliana B05.10|Rep: Putative
           uncharacterized protein - Botryotinia fuckeliana B05.10
          Length = 211

 Score =  106 bits (254), Expect = 7e-22
 Identities = 55/136 (40%), Positives = 81/136 (59%), Gaps = 1/136 (0%)
 Frame = +3

Query: 246 RISGA-RAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQ 422
           R  GA  + + S + F + ++Y  IP YR M  +G+I+D +     D+A L  MY  M++
Sbjct: 52  RFPGAVDSKFTSSLSFEHPSTYNAIPTYRTMSPDGEILDPSAVLPSDEAAL-EMYLNMIK 110

Query: 423 LSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTV 602
           +S MD I+ E+QRQGR+SFYM + GEEG    +  AL   D++FSQYRE GVF+ RG T+
Sbjct: 111 VSIMDVIMVEAQRQGRLSFYMPSQGEEGTCVGSAAALEKDDVIFSQYREAGVFMQRGFTL 170

Query: 603 TETCEPVLRKLRGSGE 650
            E    +    +  G+
Sbjct: 171 DEFMSQLFANRKDKGK 186



 Score = 40.3 bits (90), Expect = 0.049
 Identities = 16/32 (50%), Positives = 23/32 (71%)
 Frame = +1

Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVT 702
           + ++Q + N +D GK R MPVHYGSK  N+V+
Sbjct: 172 EFMSQLFANRKDKGKARNMPVHYGSKELNIVS 203


>UniRef50_Q4DB65 Cluster: 2-oxoisovalerate dehydrogenase alpha
           subunit, putative; n=3; Trypanosoma|Rep:
           2-oxoisovalerate dehydrogenase alpha subunit, putative -
           Trypanosoma cruzi
          Length = 431

 Score = 99.5 bits (237), Expect = 7e-20
 Identities = 48/114 (42%), Positives = 70/114 (61%)
 Frame = +3

Query: 267 PYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKIL 446
           P V E+ F ++  Y   P++ V+D +G++++  +EP + K TLI M + M++   +D IL
Sbjct: 45  PTVDELTF-HQRKYPSTPMFHVLDLDGRVVNPKQEPEVPKETLIKMMEAMLRQQSIDLIL 103

Query: 447 YESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608
            E+QRQGRISFYMT+ GEE        AL  +D +F QYRE     YRG TV +
Sbjct: 104 MEAQRQGRISFYMTSMGEEASAVGTAAALDMRDELFLQYREAAALTYRGYTVKD 157



 Score = 41.5 bits (93), Expect = 0.021
 Identities = 18/35 (51%), Positives = 24/35 (68%)
 Frame = +1

Query: 604 RKLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708
           + +V QC G  E+  KGRQMP+HYGS+  N+  IS
Sbjct: 156 KDMVAQCMGTIENELKGRQMPIHYGSRALNVHMIS 190


>UniRef50_A0DAM1 Cluster: Chromosome undetermined scaffold_43, whole
           genome shotgun sequence; n=3; Oligohymenophorea|Rep:
           Chromosome undetermined scaffold_43, whole genome
           shotgun sequence - Paramecium tetraurelia
          Length = 406

 Score = 98.7 bits (235), Expect = 1e-19
 Identities = 45/102 (44%), Positives = 66/102 (64%)
 Frame = +3

Query: 303 SYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFY 482
           ++EPI  +RV+D  G ++ K E  N+ K  L  ++  M+ +  MD +LY SQRQG+ISFY
Sbjct: 30  NFEPIKQFRVIDLEGNLVAK-EYNNIPKEILNQIFDLMISIEEMDNLLYMSQRQGKISFY 88

Query: 483 MTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608
           MT++GE   T     AL P+D +F QYRE G F++RG T+ +
Sbjct: 89  MTSFGETATTVGTTAALQPQDFIFPQYREQGSFMWRGFTIEQ 130



 Score = 55.6 bits (128), Expect = 1e-06
 Identities = 24/34 (70%), Positives = 28/34 (82%)
 Frame = +1

Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708
           ++VNQC GN  D GKGRQMPVHYGSK  N+VT+S
Sbjct: 130 QIVNQCIGNHLDGGKGRQMPVHYGSKDLNIVTVS 163


>UniRef50_Q4Y3F8 Cluster: Branched-chain alpha keto-acid
           dehydrogenase, putative; n=7; Plasmodium|Rep:
           Branched-chain alpha keto-acid dehydrogenase, putative -
           Plasmodium chabaudi
          Length = 432

 Score = 98.3 bits (234), Expect = 2e-19
 Identities = 51/125 (40%), Positives = 78/125 (62%)
 Frame = +3

Query: 270 YVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILY 449
           + +++K  NE +   +PI+R++D NG ++D +  P  D   ++N+YK MV+ S  D+I Y
Sbjct: 48  FSTDLKTVNEVA--KLPIFRILDTNGNLLDGHTAP-FDDEEVLNLYKQMVEFSIWDEIFY 104

Query: 450 ESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLR 629
             QRQGRISFY+ N GEEG+     +AL+  D ++ QYRE G+ L RG T     E +L 
Sbjct: 105 GIQRQGRISFYIVNDGEEGLHFGIGKALTVDDHLYCQYRETGILLSRGFTY----EDILN 160

Query: 630 KLRGS 644
           +L G+
Sbjct: 161 QLFGT 165


>UniRef50_Q4P2J0 Cluster: Putative uncharacterized protein; n=1;
           Ustilago maydis|Rep: Putative uncharacterized protein -
           Ustilago maydis (Smut fungus)
          Length = 786

 Score = 95.5 bits (227), Expect = 1e-18
 Identities = 48/105 (45%), Positives = 66/105 (62%), Gaps = 2/105 (1%)
 Frame = +3

Query: 294 NETSYEPIPIYRVMDNNGQIID--KNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQG 467
           N+ S   IP YR+MD  G+++     E  N+ +   + MY+TM+ L  +D ILY +QRQG
Sbjct: 390 NKNSQGGIPTYRLMDGVGRLLPGVTQEMINITQQEAVKMYRTMLLLPQIDVILYNAQRQG 449

Query: 468 RISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTV 602
           RISF MT+YGEEG    +   L  KD VF+QYRE GV L+R  ++
Sbjct: 450 RISFMMTSYGEEGAVIGSAAGLDAKDEVFAQYRESGVLLWRDFSI 494



 Score = 35.9 bits (79), Expect = 1.0
 Identities = 15/32 (46%), Positives = 22/32 (68%)
 Frame = +1

Query: 613 VNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708
           ++Q +G  +D   GRQMP+H+GS  H+  TIS
Sbjct: 498 MSQVFGAEDDLCGGRQMPIHFGSTQHHFHTIS 529


>UniRef50_Q5KGR5 Cluster: Branched-chain alpha-keto acid
           dehydrogenase E1-alpha subunit, putative; n=2;
           Filobasidiella neoformans|Rep: Branched-chain alpha-keto
           acid dehydrogenase E1-alpha subunit, putative -
           Cryptococcus neoformans (Filobasidiella neoformans)
          Length = 504

 Score = 93.9 bits (223), Expect = 4e-18
 Identities = 52/153 (33%), Positives = 79/153 (51%), Gaps = 1/153 (0%)
 Frame = +3

Query: 276 SEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYES 455
           +EM +FN  + + IP +RV+D  G ++    E    K   +++Y+TM  +  +D +LY+S
Sbjct: 97  AEMGWFNAVA-KTIPTFRVLDEEGHMVKDGHESQATKEQTLSIYRTMTLIPIVDNVLYQS 155

Query: 456 QRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKL 635
           QRQGRISFYM   GEE     +  A+   D +F QYRE    L+RG T+          +
Sbjct: 156 QRQGRISFYMQCAGEEAAIVGSAAAMLANDEIFGQYRESAALLHRGFTLDALMAQCFGNV 215

Query: 636 RGSGERETDAGPLRKQAPQHG-HNILVH*GTQI 731
              G +     P+   +P+HG H I     TQ+
Sbjct: 216 DDKGTKGR-MMPVHYSSPEHGFHTITSPLATQM 247


>UniRef50_Q1KSF2 Cluster: Mitochondrial branched-chain alpha-keto
           acid dehydrogenase E1; n=1; Toxoplasma gondii|Rep:
           Mitochondrial branched-chain alpha-keto acid
           dehydrogenase E1 - Toxoplasma gondii
          Length = 463

 Score = 92.7 bits (220), Expect = 9e-18
 Identities = 49/121 (40%), Positives = 71/121 (58%)
 Frame = +3

Query: 270 YVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILY 449
           + ++M   NET    IPI+R++D +GQI D  + P +    ++  Y+ MV+LS  D + Y
Sbjct: 78  FTTDMNISNETPV--IPIFRILDYDGQIADGWQCP-MTNDEVLEAYQFMVKLSIWDNMFY 134

Query: 450 ESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLR 629
             QRQGRISFY+ N GEE +  A   AL  KD +F QYRE+GV +  G T  +  E +  
Sbjct: 135 SVQRQGRISFYIQNQGEEALQTAVGLALDKKDHLFCQYRELGVLMLHGFTAEDALEQLFA 194

Query: 630 K 632
           +
Sbjct: 195 R 195


>UniRef50_Q6YPX5 Cluster: Thiamine pyrophosphate-dependent
           dehydrogenase, E1 component alpha subunit; n=2;
           Candidatus Phytoplasma asteris|Rep: Thiamine
           pyrophosphate-dependent dehydrogenase, E1 component
           alpha subunit - Onion yellows phytoplasma
          Length = 363

 Score = 81.4 bits (192), Expect = 2e-14
 Identities = 39/103 (37%), Positives = 59/103 (57%), Gaps = 2/103 (1%)
 Frame = +3

Query: 306 YEPIP--IYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISF 479
           Y+P+    ++++D NG ++    EP L K  L+ MYKTMV     D    + QRQGR+  
Sbjct: 6   YDPLKGKQFQILDENGNLVQPELEPKLSKDVLLKMYKTMVLGRQADLAALKYQRQGRMGN 65

Query: 480 YMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608
           Y+ N G+E        AL P+D V   YR+ G+FLYRG+++ +
Sbjct: 66  YLLNSGQEASQVGVAAALEPQDWVSPYYRDAGIFLYRGVSLEQ 108


>UniRef50_Q5QUK4 Cluster: Alpha keto acid dehydrogenase complex, E1
           component, alpha subunit; n=32; Gammaproteobacteria|Rep:
           Alpha keto acid dehydrogenase complex, E1 component,
           alpha subunit - Idiomarina loihiensis
          Length = 395

 Score = 79.0 bits (186), Expect = 1e-13
 Identities = 39/112 (34%), Positives = 66/112 (58%)
 Frame = +3

Query: 273 VSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYE 452
           V++ K+F++ S   IP+ +++  +G      + P  DK  ++ ++ TM  +  +D+ +  
Sbjct: 12  VTKPKWFDKDSVT-IPMLQILKEDGSFHKDADMPEYDKELIVKIHDTMQFIRILDERMIA 70

Query: 453 SQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608
           +QRQGRISFY+ + GEE  + A+  AL   D++  QYRE G   YRG TV +
Sbjct: 71  AQRQGRISFYLASRGEEAESVASAAALDAGDMIMGQYREQGALAYRGFTVEQ 122



 Score = 44.0 bits (99), Expect = 0.004
 Identities = 19/34 (55%), Positives = 24/34 (70%)
 Frame = +1

Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708
           + +NQ + N +D GKGRQMPVHYG    N +TIS
Sbjct: 122 QFMNQLFSNEKDLGKGRQMPVHYGCADLNFMTIS 155


>UniRef50_Q4QC52 Cluster: 2-oxoisovalerate dehydrogenase alpha
           subunit, putative; n=3; Leishmania|Rep: 2-oxoisovalerate
           dehydrogenase alpha subunit, putative - Leishmania major
          Length = 479

 Score = 75.4 bits (177), Expect = 1e-12
 Identities = 35/69 (50%), Positives = 45/69 (65%)
 Frame = +3

Query: 402 MYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVF 581
           M   M+  + MDKI+ E+QRQGRISFYMT +GEE     A   L+  D +F+QYRE G+ 
Sbjct: 124 MMSAMLTHNTMDKIMLEAQRQGRISFYMTMFGEEAAVIGAAAGLASNDELFAQYREAGIL 183

Query: 582 LYRGMTVTE 608
            YRG T+ E
Sbjct: 184 TYRGYTIPE 192



 Score = 46.8 bits (106), Expect = 6e-04
 Identities = 20/34 (58%), Positives = 24/34 (70%), Gaps = 2/34 (5%)
 Frame = +1

Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSK--HHNMVT 702
           + + QC GNCE   KGRQMP+HYGSK  H  MV+
Sbjct: 192 EFIAQCMGNCECDAKGRQMPIHYGSKRLHAQMVS 225


>UniRef50_Q9HN77 Cluster: Pyruvate dehydrogenase alpha subunit; n=8;
           Halobacteriaceae|Rep: Pyruvate dehydrogenase alpha
           subunit - Halobacterium salinarium (Halobacterium
           halobium)
          Length = 419

 Score = 72.5 bits (170), Expect = 1e-11
 Identities = 38/100 (38%), Positives = 53/100 (53%)
 Frame = +3

Query: 312 PIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTN 491
           P   YRV+D NG+++D  E P+L    L+ MY+ M      D+     QRQGRI  Y   
Sbjct: 57  PDDTYRVLDENGELVDGAEVPDLTDDELVEMYRYMKLARRFDERAVSLQRQGRIGTYPPL 116

Query: 492 YGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTET 611
            G+EG   A+  AL+  D +   YRE G  L RG+ + +T
Sbjct: 117 SGQEGAQIASAMALADDDWIVPSYREHGASLVRGLPLKDT 156


>UniRef50_A7HBV0 Cluster: 3-methyl-2-oxobutanoate dehydrogenase;
           n=4; Cystobacterineae|Rep: 3-methyl-2-oxobutanoate
           dehydrogenase - Anaeromyxobacter sp. Fw109-5
          Length = 399

 Score = 71.3 bits (167), Expect = 2e-11
 Identities = 36/101 (35%), Positives = 58/101 (57%), Gaps = 1/101 (0%)
 Frame = +3

Query: 318 PIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYG 497
           P+YR++  +G+++   +E  L  A ++ +Y+ MV    +D+ +   QRQGRI FY+ + G
Sbjct: 31  PLYRLVAEDGELVGAPDEVTLPDAEVLRLYRLMVLNRSLDERMITLQRQGRIGFYIGSIG 90

Query: 498 EEGIT*AAPRALSPKDLVFSQYREVGVFLYRGM-TVTETCE 617
           EE     +  A++  D +F  YRE G  L RGM  VT  C+
Sbjct: 91  EEATILGSAAAMAESDWIFPCYREHGAALMRGMPLVTFLCD 131


>UniRef50_Q9YBC0 Cluster: Pyruvate dehydrogenase E1 component, alpha
           subunit; n=1; Aeropyrum pernix|Rep: Pyruvate
           dehydrogenase E1 component, alpha subunit - Aeropyrum
           pernix
          Length = 377

 Score = 68.9 bits (161), Expect = 1e-10
 Identities = 31/100 (31%), Positives = 55/100 (55%)
 Frame = +3

Query: 327 RVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEG 506
           R +D  G+++D+   P + +  ++ +Y  MV+   +D  L + QR G+++ +  N G+E 
Sbjct: 16  RAVDEEGRVVDEELLPKVSEGEIVEIYTYMVRARVIDSWLLKLQRMGKVALHAPNKGQEA 75

Query: 507 IT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVL 626
           +   A + L   D VF  YRE+G +L RGM+  E  +  L
Sbjct: 76  VAVGAAKPLRRDDWVFPSYRELGAYLVRGMSEEEILDRAL 115


>UniRef50_P35485 Cluster: Pyruvate dehydrogenase E1 component
           subunit alpha; n=2; Firmicutes|Rep: Pyruvate
           dehydrogenase E1 component subunit alpha - Acholeplasma
           laidlawii
          Length = 345

 Score = 68.5 bits (160), Expect = 2e-10
 Identities = 34/86 (39%), Positives = 47/86 (54%)
 Frame = +3

Query: 336 DNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT* 515
           D NG+++++  EP L K TL+ MYKT V   + D    + QRQGR+  Y  N G+E    
Sbjct: 1   DQNGKVVNEKMEPKLPKETLLKMYKTAVLGRNADIKALQYQRQGRMLTYAPNMGQEAAQI 60

Query: 516 AAPRALSPKDLVFSQYREVGVFLYRG 593
               A+ P+D     YRE+   LYRG
Sbjct: 61  GMAAAMEPQDWNSPMYRELNTLLYRG 86


>UniRef50_Q4N1L6 Cluster: Branched-chain alpha keto-acid
           dehydrogenase, putative; n=3; Piroplasmida|Rep:
           Branched-chain alpha keto-acid dehydrogenase, putative -
           Theileria parva
          Length = 464

 Score = 66.9 bits (156), Expect = 5e-10
 Identities = 34/89 (38%), Positives = 51/89 (57%)
 Frame = +3

Query: 300 TSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISF 479
           T  + +PI++VM  +G + + ++ P      +    + MV+L+  D + Y  QRQGRISF
Sbjct: 75  TDSQVMPIFQVMKTDGTLHEGHKSPFESDEKVKEYLQIMVKLNVWDNLFYNIQRQGRISF 134

Query: 480 YMTNYGEEGIT*AAPRALSPKDLVFSQYR 566
           Y+ N GEE     A  AL P+D +F QYR
Sbjct: 135 YIQNQGEEATQLGAGLALQPQDHLFCQYR 163



 Score = 35.1 bits (77), Expect = 1.8
 Identities = 16/42 (38%), Positives = 24/42 (57%)
 Frame = +1

Query: 583 YTEG*L*RKLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708
           Y +G     ++ Q +   +D GKGRQMP+ Y  K  N+ TI+
Sbjct: 179 YVKGCTEDDVLAQLFSTHKDEGKGRQMPISYSKKEVNLHTIT 220


>UniRef50_Q4L1A7 Cluster: Pyruvate dehydrogenase E1 component alpha
           subunit; n=9; Mycoplasma|Rep: Pyruvate dehydrogenase E1
           component alpha subunit - Mycoplasma synoviae
          Length = 374

 Score = 58.4 bits (135), Expect = 2e-07
 Identities = 34/97 (35%), Positives = 47/97 (48%), Gaps = 1/97 (1%)
 Frame = +3

Query: 309 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 488
           +P  + RV+D NG +IDK  +P L    L+  YK MV     D  + + QRQGR+  +  
Sbjct: 20  DPSKLIRVLDVNGNLIDKKYKPQLTDKQLVEGYKWMVLSRQQDTYMLQLQRQGRMLTFAP 79

Query: 489 NYGEEGIT*AAPRAL-SPKDLVFSQYREVGVFLYRGM 596
           N GEE +  A   AL   KD     +R     L  G+
Sbjct: 80  NLGEEALQVATAFALDKKKDWFLPAFRSNATMLALGV 116


>UniRef50_Q5KUY4 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
           alpha subunit; n=2; Geobacillus|Rep: Pyruvate
           dehydrogenase E1 (Lipoamide) alpha subunit - Geobacillus
           kaustophilus
          Length = 359

 Score = 57.6 bits (133), Expect = 3e-07
 Identities = 36/110 (32%), Positives = 52/110 (47%)
 Frame = +3

Query: 312 PIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTN 491
           P+ I R++D NG   D+ +        L+  Y+ M +   +D+ L   QRQGRI  Y   
Sbjct: 8   PVEIVRILDENGNG-DEEKLAAFSDEWLLRAYREMRRARVIDERLLRMQRQGRIGTYAPF 66

Query: 492 YGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRG 641
            G+E     +  AL   D +F  YREV V L  GM + +    V  +L G
Sbjct: 67  SGQEAAQIGSALALHKDDWIFPSYREVAVCLMHGMPLEQFFHYVQGRLSG 116


>UniRef50_Q8CX87 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
           alpha subunit; n=5; Bacillaceae|Rep: Pyruvate
           dehydrogenase E1 (Lipoamide) alpha subunit -
           Oceanobacillus iheyensis
          Length = 358

 Score = 56.8 bits (131), Expect = 5e-07
 Identities = 31/99 (31%), Positives = 48/99 (48%)
 Frame = +3

Query: 309 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 488
           E  P+ R+MD NG+I D +    +DKA +   Y+ ++ +   D+     QRQGRI  Y  
Sbjct: 7   EEFPMIRIMDQNGKITDTSYLEQIDKALVQQFYRQLICMRAFDQKAINLQRQGRIGTYPG 66

Query: 489 NYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVT 605
             G+EG    +  AL   D +   YR+    +  G + T
Sbjct: 67  FEGQEGAQVGSALALDEDDWMLPTYRDHAASITFGKSYT 105


>UniRef50_A6CP23 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
           alpha subunit; n=2; Bacillus sp. SG-1|Rep: Pyruvate
           dehydrogenase E1 (Lipoamide) alpha subunit - Bacillus
           sp. SG-1
          Length = 364

 Score = 55.2 bits (127), Expect = 2e-06
 Identities = 31/99 (31%), Positives = 49/99 (49%)
 Frame = +3

Query: 297 ETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRIS 476
           E   E  PI R++DN+G ++  +++P + +      Y+ MV++   DK     QRQGRI 
Sbjct: 9   EEMEEQFPIKRIIDNDGTLLG-DKDPGITEQLAKEFYRHMVRIRTFDKKAISLQRQGRIG 67

Query: 477 FYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRG 593
            Y    G+E     +  AL   D +F  YR+ G  +  G
Sbjct: 68  TYAPFEGQEASQVGSSAALKEDDWMFPSYRDHGAAMTFG 106


>UniRef50_P21873 Cluster: Pyruvate dehydrogenase E1 component
           subunit alpha; n=33; Bacilli|Rep: Pyruvate dehydrogenase
           E1 component subunit alpha - Bacillus stearothermophilus
           (Geobacillus stearothermophilus)
          Length = 369

 Score = 54.8 bits (126), Expect = 2e-06
 Identities = 25/96 (26%), Positives = 48/96 (50%)
 Frame = +3

Query: 309 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 488
           E  P +++++  G+++++   P L    L  + + MV    +D+      RQGR+ FY  
Sbjct: 19  EQFPTFQILNEEGEVVNEEAMPELSDEQLKELMRRMVYTRILDQRSISLNRQGRLGFYAP 78

Query: 489 NYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596
             G+E    A+  AL  +D +   YR+V   ++ G+
Sbjct: 79  TAGQEASQIASHFALEKEDFILPGYRDVPQIIWHGL 114


>UniRef50_P47516 Cluster: Pyruvate dehydrogenase E1 component
           subunit alpha; n=5; Mycoplasma|Rep: Pyruvate
           dehydrogenase E1 component subunit alpha - Mycoplasma
           genitalium
          Length = 358

 Score = 54.4 bits (125), Expect = 3e-06
 Identities = 31/95 (32%), Positives = 46/95 (48%)
 Frame = +3

Query: 312 PIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTN 491
           P  +Y+V DN G++ID N +  L    L + Y  M     MDK +   QR G++  +  N
Sbjct: 10  PTTLYQVYDNEGKLIDPNHKITLTDEQLKHAYYLMNLSRMMDKKMLVWQRAGKMLNFAPN 69

Query: 492 YGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596
            GEE +       L+  D V   +R   + LYRG+
Sbjct: 70  LGEEALQVGMGLGLNENDWVCPTFRSGALMLYRGV 104


>UniRef50_A1UJ85 Cluster: Pyruvate dehydrogenase; n=16;
           Mycobacterium|Rep: Pyruvate dehydrogenase -
           Mycobacterium sp. (strain KMS)
          Length = 356

 Score = 54.0 bits (124), Expect = 4e-06
 Identities = 28/74 (37%), Positives = 39/74 (52%)
 Frame = +3

Query: 375 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVF 554
           +L   TL  +Y+TMV    +D      QRQG ++ Y +  G+E     A   L   D +F
Sbjct: 27  DLPPETLAWLYETMVVTRDLDTEFVHLQRQGELALYASCRGQEAAQIGATACLRKTDWLF 86

Query: 555 SQYREVGVFLYRGM 596
            QYRE+G FL RG+
Sbjct: 87  PQYREIGAFLLRGI 100


>UniRef50_A7K3C9 Cluster: Dehydrogenase E1 component superfamily;
           n=10; Gammaproteobacteria|Rep: Dehydrogenase E1
           component superfamily - Vibrio sp. Ex25
          Length = 398

 Score = 53.6 bits (123), Expect = 5e-06
 Identities = 39/145 (26%), Positives = 64/145 (44%), Gaps = 1/145 (0%)
 Frame = +3

Query: 297 ETSYEPIPIYRVMDNNGQIIDKNEEPN-LDKATLINMYKTMVQLSHMDKILYESQRQGRI 473
           E + + +P++R +D++G ++   + PN  D  TL+  Y+ MV     D      QR G++
Sbjct: 34  EMNVQALPMHRFIDHHGDLV--GQLPNWADTETLVGFYRDMVLTRTYDNKAVALQRTGKL 91

Query: 474 SFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRGSGER 653
             Y ++ G E I  A  RAL   D+    YR++     RG+ + +  +       G  ER
Sbjct: 92  GTYPSHLGAEAIGIAVGRALKADDVFVPYYRDMPAMWCRGIGMEKNLQ-----YWGGDER 146

Query: 654 ETDAGPLRKQAPQHGHNILVH*GTQ 728
            +D  P     P       V   TQ
Sbjct: 147 GSDFAPEGSPIPSRDLPFCVPIATQ 171


>UniRef50_Q97CK0 Cluster: 2-oxoisovalerate dehydrogenase alpha
           subunit; n=2; Thermoplasma|Rep: 2-oxoisovalerate
           dehydrogenase alpha subunit - Thermoplasma volcanium
          Length = 337

 Score = 52.8 bits (121), Expect = 9e-06
 Identities = 33/104 (31%), Positives = 53/104 (50%)
 Frame = +3

Query: 384 KATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQY 563
           K+  +  + +MV     DK +  +QRQG + FY    G+E     A  ALS +DLV+  Y
Sbjct: 10  KSLYVKGFTSMVLGRLFDKKVITAQRQGLVGFYTPMMGQEATQAGAAMALSKQDLVYGYY 69

Query: 564 REVGVFLYRGMTVTETCEPVLRKLRGSGERETDAGPLRKQAPQH 695
           R+V + +Y G  +    E +  ++ G+ E +T  G   +Q P H
Sbjct: 70  RDVTLLIYLGYPI----EKIFDQIMGNAE-DTSKG---RQMPSH 105



 Score = 40.3 bits (90), Expect = 0.049
 Identities = 16/33 (48%), Positives = 22/33 (66%)
 Frame = +1

Query: 607 KLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTI 705
           K+ +Q  GN ED  KGRQMP HY +K  N +++
Sbjct: 84  KIFDQIMGNAEDTSKGRQMPSHYSAKAVNFMSV 116


>UniRef50_Q835M4 Cluster: Pyruvate dehydrogenase complex E1
           component, alpha subunit; n=10; Bacilli|Rep: Pyruvate
           dehydrogenase complex E1 component, alpha subunit -
           Enterococcus faecalis (Streptococcus faecalis)
          Length = 371

 Score = 52.0 bits (119), Expect = 1e-05
 Identities = 25/97 (25%), Positives = 51/97 (52%)
 Frame = +3

Query: 318 PIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYG 497
           P ++++D +G+I++++  P+L    L+ +   MV    +D+      RQGR+ F+    G
Sbjct: 24  PTFQILDQDGKIVNEDLVPDLSDEELVELMTRMVWSRVLDQRSTALNRQGRLGFFAPTAG 83

Query: 498 EEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608
           +E    A+  A+  +D +   YR+V   +  G+ + E
Sbjct: 84  QEASQLASQFAMEKEDYLLPGYRDVPQLVQHGLPLRE 120


>UniRef50_A7D3P2 Cluster: Pyruvate dehydrogenase; n=1; Halorubrum
           lacusprofundi ATCC 49239|Rep: Pyruvate dehydrogenase -
           Halorubrum lacusprofundi ATCC 49239
          Length = 382

 Score = 51.6 bits (118), Expect = 2e-05
 Identities = 29/91 (31%), Positives = 44/91 (48%)
 Frame = +3

Query: 324 YRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 503
           YRV+  +G  +     P+L       +Y+ +V     D+     QRQGRI  Y    G+E
Sbjct: 22  YRVLGPDGIPLPDATVPDLSDERFRAIYRDLVTTRRFDERAVSLQRQGRIGTYAPCAGQE 81

Query: 504 GIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596
           G    +  AL+ +DL+  QYRE G  + R +
Sbjct: 82  GSAVGSTHALADRDLISYQYREHGAIVVRDL 112


>UniRef50_A0LLM4 Cluster: Pyruvate dehydrogenase; n=1;
           Syntrophobacter fumaroxidans MPOB|Rep: Pyruvate
           dehydrogenase - Syntrophobacter fumaroxidans (strain DSM
           10017 / MPOB)
          Length = 365

 Score = 50.4 bits (115), Expect = 5e-05
 Identities = 27/88 (30%), Positives = 49/88 (55%)
 Frame = +3

Query: 330 VMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGI 509
           +++ NG++ DK+ EP++ ++ L+ +Y+ MV     D+ +   QRQGRI  +    G+E  
Sbjct: 17  ILNENGEV-DKSLEPDIPESLLVKLYRAMVLSRKFDERMLILQRQGRIGTFAPIKGQEAQ 75

Query: 510 T*AAPRALSPKDLVFSQYREVGVFLYRG 593
              A   L P D +   +RE+   ++RG
Sbjct: 76  V-GAVALLEPGDWLVPSFREMPAEVWRG 102


>UniRef50_Q0W151 Cluster: Pyruvate dehydrogenase complex E1,
           transketolase alpha subunit; n=1; uncultured
           methanogenic archaeon RC-I|Rep: Pyruvate dehydrogenase
           complex E1, transketolase alpha subunit - Uncultured
           methanogenic archaeon RC-I
          Length = 359

 Score = 50.0 bits (114), Expect = 6e-05
 Identities = 28/92 (30%), Positives = 49/92 (53%), Gaps = 1/92 (1%)
 Frame = +3

Query: 324 YRVMDNNGQIIDKNE-EPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGE 500
           +R++  +G     NE +P L +  L+ MY+ MVQ    D+   + QR GR+  Y    G+
Sbjct: 15  FRIVSQDGSA---NELDPGLPEDLLLKMYRLMVQARTYDEKALKLQRGGRMGTYPPIAGQ 71

Query: 501 EGIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596
           E I   +  A++ +D +   YRE+G  + +G+
Sbjct: 72  EAIQIGSALAMAEEDWMVPSYREIGAMIAKGV 103


>UniRef50_A5UU15 Cluster: Pyruvate dehydrogenase; n=3; Chloroflexi
           (class)|Rep: Pyruvate dehydrogenase - Roseiflexus sp.
           RS-1
          Length = 350

 Score = 49.6 bits (113), Expect = 8e-05
 Identities = 28/94 (29%), Positives = 47/94 (50%), Gaps = 1/94 (1%)
 Frame = +3

Query: 363 NEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIT*AAPRALSP 539
           + +  LD ATLI+ Y+ MV +   ++   E   + +I  ++  Y GEE     A  AL P
Sbjct: 16  SNDSGLDAATLIDYYRQMVLIRRFEEKCQEMYTRAKIGGFLHLYIGEEATAVGAIAALRP 75

Query: 540 KDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRG 641
            D +F+ YR+ G  + RG+ +      +  K+ G
Sbjct: 76  DDHIFTHYRDHGHAIARGLDINALMAELFGKVTG 109


>UniRef50_Q9KG99 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
           alpha subunit; n=1; Bacillus halodurans|Rep: Pyruvate
           dehydrogenase E1 (Lipoamide) alpha subunit - Bacillus
           halodurans
          Length = 367

 Score = 49.2 bits (112), Expect = 1e-04
 Identities = 27/83 (32%), Positives = 43/83 (51%)
 Frame = +3

Query: 321 IYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGE 500
           +++V+   G+   +  E  LDK  +++MYK M+     D+   + QRQGRI  Y +  G+
Sbjct: 18  LFQVLTPKGECQYEGSE-FLDKTFVLSMYKQMINCREFDEKALKLQRQGRIGTYASFKGQ 76

Query: 501 EGIT*AAPRALSPKDLVFSQYRE 569
           E        AL P D +F  YR+
Sbjct: 77  EACQIGGALALRPTDWLFPTYRD 99


>UniRef50_A0K283 Cluster: Pyruvate dehydrogenase; n=4;
           Actinobacteria (class)|Rep: Pyruvate dehydrogenase -
           Arthrobacter sp. (strain FB24)
          Length = 415

 Score = 48.8 bits (111), Expect = 1e-04
 Identities = 29/88 (32%), Positives = 44/88 (50%)
 Frame = +3

Query: 378 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFS 557
           LD   L   Y  M  +   D+     QRQG+++ ++   G+E     + RA  P+D +F 
Sbjct: 58  LDAEKLRGFYADMAAIRRFDQEATALQRQGQLALWVPLTGQEAAQIGSGRASQPQDYIFP 117

Query: 558 QYREVGVFLYRGMTVTETCEPVLRKLRG 641
            YRE GV L R + + E    +LR+ RG
Sbjct: 118 TYREHGVALTRNVDLAE----LLRQFRG 141


>UniRef50_UPI00005103B4 Cluster: COG1071: Pyruvate/2-oxoglutarate
           dehydrogenase complex, dehydrogenase (E1) component,
           eukaryotic type, alpha subunit; n=1; Brevibacterium
           linens BL2|Rep: COG1071: Pyruvate/2-oxoglutarate
           dehydrogenase complex, dehydrogenase (E1) component,
           eukaryotic type, alpha subunit - Brevibacterium linens
           BL2
          Length = 368

 Score = 48.4 bits (110), Expect = 2e-04
 Identities = 25/74 (33%), Positives = 38/74 (51%)
 Frame = +3

Query: 387 ATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYR 566
           A L  +Y+ MV +   +  +    RQGR++ Y +  G+E     A  AL+P D +F  YR
Sbjct: 41  AALTGLYRQMVLVRRFEAQVTHLTRQGRLATYPSAAGQEAAEVGATTALAPNDWLFPTYR 100

Query: 567 EVGVFLYRGMTVTE 608
           +    L RG+ V E
Sbjct: 101 DSAALLTRGVPVAE 114


>UniRef50_Q4MTG0 Cluster: Pyruvate dehydrogenase E1 component
           subunit alpha; n=38; Bacilli|Rep: Pyruvate dehydrogenase
           E1 component subunit alpha - Bacillus cereus
          Length = 371

 Score = 48.0 bits (109), Expect = 2e-04
 Identities = 23/90 (25%), Positives = 45/90 (50%)
 Frame = +3

Query: 327 RVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEG 506
           ++++  G+++++   P L    L  + + MV    +D+      RQGR+ FY    G+E 
Sbjct: 27  QILNEKGEVVNEAAMPELSDDQLKELMRRMVYTRVLDQRSISLNRQGRLGFYAPTAGQEA 86

Query: 507 IT*AAPRALSPKDLVFSQYREVGVFLYRGM 596
              A+  AL  +D +   YR+V   ++ G+
Sbjct: 87  SQLASHFALEAEDFILPGYRDVPQLVWHGL 116


>UniRef50_Q8EVQ2 Cluster: Pyruvate dehydrogenase E1 component
           subunit alpha; n=1; Mycoplasma penetrans|Rep: Pyruvate
           dehydrogenase E1 component subunit alpha - Mycoplasma
           penetrans
          Length = 359

 Score = 47.6 bits (108), Expect = 3e-04
 Identities = 26/91 (28%), Positives = 43/91 (47%)
 Frame = +3

Query: 324 YRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 503
           Y V+D +G +        L    +   Y TMV    MD+ + + QRQG++  +  N GEE
Sbjct: 13  YSVLDIDGNVTQVGYRIPLSNEEIEKAYYTMVLTRRMDEKMIKWQRQGKMLTFPPNMGEE 72

Query: 504 GIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596
            +  A   ++  +D     +R   VFL+ G+
Sbjct: 73  ALQVATSISMDKQDWFAPAFRSAAVFLHSGV 103


>UniRef50_P09060 Cluster: 2-oxoisovalerate dehydrogenase subunit
           alpha; n=68; Proteobacteria|Rep: 2-oxoisovalerate
           dehydrogenase subunit alpha - Pseudomonas putida
          Length = 410

 Score = 47.6 bits (108), Expect = 3e-04
 Identities = 28/96 (29%), Positives = 48/96 (50%)
 Frame = +3

Query: 321 IYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGE 500
           + RV+D  G       E ++D   L    + M++    D  +  +QRQ ++SFYM + GE
Sbjct: 54  LVRVLDEQGDAQGPWAE-DIDPQILRQGMRAMLKTRIFDSRMVVAQRQKKMSFYMQSLGE 112

Query: 501 EGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608
           E I      AL+  D+ F  YR+  + + R +++ E
Sbjct: 113 EAIGSGQALALNRTDMCFPTYRQQSILMARDVSLVE 148


>UniRef50_A0JUQ5 Cluster: Pyruvate dehydrogenase; n=4;
           Actinobacteria (class)|Rep: Pyruvate dehydrogenase -
           Arthrobacter sp. (strain FB24)
          Length = 392

 Score = 47.2 bits (107), Expect = 4e-04
 Identities = 29/98 (29%), Positives = 46/98 (46%)
 Frame = +3

Query: 399 NMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGV 578
           ++Y+ MV +  +D      QRQG +  +    G+E     + R+L   D VFS YRE GV
Sbjct: 60  SLYEDMVVIRRIDTEATALQRQGELGLWPPLLGQEASQIGSARSLRDDDFVFSSYRENGV 119

Query: 579 FLYRGMTVTETCEPVLRKLRGSGERETDAGPLRKQAPQ 692
              RG+ + +    +L+  RG+     D   +    PQ
Sbjct: 120 AYCRGVDLAD----ILKVWRGNASAGWDPYTINMATPQ 153


>UniRef50_Q6L1L8 Cluster: Pyruvate dehydrogenase E1 component alpha
           subunit; n=2; Thermoplasmatales|Rep: Pyruvate
           dehydrogenase E1 component alpha subunit - Picrophilus
           torridus
          Length = 333

 Score = 46.4 bits (105), Expect = 7e-04
 Identities = 23/69 (33%), Positives = 36/69 (52%)
 Frame = +3

Query: 369 EPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDL 548
           E ++ K  +I+ Y+ MV    +DK L    RQG + FY+ N G E +  A   A+   D 
Sbjct: 3   EEDISKEDIISAYRNMVLERFLDKKLLGINRQGFLPFYIPNIGHEALHAAIGMAIRDDDF 62

Query: 549 VFSQYREVG 575
            +  YR++G
Sbjct: 63  FYPYYRDLG 71


>UniRef50_Q1LFS5 Cluster: Dehydrogenase, E1 component; n=22;
           Proteobacteria|Rep: Dehydrogenase, E1 component -
           Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM
           2839)
          Length = 367

 Score = 46.0 bits (104), Expect = 0.001
 Identities = 28/90 (31%), Positives = 44/90 (48%), Gaps = 5/90 (5%)
 Frame = +3

Query: 357 DKNEEPNL-----DKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AA 521
           D + EP+L     D ATL+ +Y+ MV     D      QR G+I  + +  G+E I    
Sbjct: 18  DGSPEPDLPDFARDPATLLPLYRAMVLTRQFDLKAIAMQRTGQIGTFASALGQEAIGVGV 77

Query: 522 PRALSPKDLVFSQYREVGVFLYRGMTVTET 611
             A+   D++   YR+      RG+T+TE+
Sbjct: 78  ATAMRRDDVLVPSYRDHAAQFVRGVTMTES 107


>UniRef50_Q2J998 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp.
           CcI3|Rep: Pyruvate dehydrogenase - Frankia sp. (strain
           CcI3)
          Length = 417

 Score = 44.8 bits (101), Expect = 0.002
 Identities = 30/106 (28%), Positives = 49/106 (46%), Gaps = 1/106 (0%)
 Frame = +3

Query: 327 RVMDNNGQII-DKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 503
           R++  +G ++ D       D    +  Y +MV    +D+     QRQG +  ++   G+E
Sbjct: 52  RLLAPDGSLVADSRFSVLADHELRMEFYTSMVLARRLDEEATALQRQGELVLWIPLRGQE 111

Query: 504 GIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRG 641
                +  A  P+D +F  YRE  V  +RG+   E    V+R LRG
Sbjct: 112 AAQVGSAAAARPRDYLFPSYREHAVAWHRGVPAVE----VIRLLRG 153


>UniRef50_Q3W421 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp.
           EAN1pec|Rep: Pyruvate dehydrogenase - Frankia sp.
           EAN1pec
          Length = 358

 Score = 44.8 bits (101), Expect = 0.002
 Identities = 30/106 (28%), Positives = 48/106 (45%), Gaps = 1/106 (0%)
 Frame = +3

Query: 327 RVMDNNGQIIDKNE-EPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 503
           R++  +G ++D        D     + Y+ MV+   +D+     QRQG +  ++   G+E
Sbjct: 19  RLLAPDGTLVDDPRFTVRADSRQTESFYREMVRARRLDEEATALQRQGELVLWIPLRGQE 78

Query: 504 GIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRG 641
                +  A  P D +F  YRE  V  +RG+   E     LR LRG
Sbjct: 79  AAQVGSAAAAEPADFLFPSYREHAVVWHRGIPPVE----ALRLLRG 120


>UniRef50_O48615 Cluster: Alpha-keto acid dehydrogenase-like
           protein; n=21; Eukaryota|Rep: Alpha-keto acid
           dehydrogenase-like protein - Hordeum vulgare (Barley)
          Length = 64

 Score = 44.8 bits (101), Expect = 0.002
 Identities = 19/35 (54%), Positives = 24/35 (68%)
 Frame = +1

Query: 604 RKLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS 708
           ++  NQ +GN  D GKGRQMP+HYGS   N+ T S
Sbjct: 27  QEFANQLFGNNLDYGKGRQMPIHYGSNRLNLFTRS 61



 Score = 36.3 bits (80), Expect = 0.79
 Identities = 16/27 (59%), Positives = 20/27 (74%)
 Frame = +3

Query: 528 ALSPKDLVFSQYREVGVFLYRGMTVTE 608
           ALS +D+V  QYRE GV L+RG T+ E
Sbjct: 2   ALSAQDIVLPQYREPGVLLWRGFTLQE 28


>UniRef50_Q1AZ54 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacter
           xylanophilus DSM 9941|Rep: Pyruvate dehydrogenase -
           Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
          Length = 325

 Score = 44.4 bits (100), Expect = 0.003
 Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
 Frame = +3

Query: 354 IDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRIS-FYMTNYGEEGIT*AAPRA 530
           +++ E P  ++  L++ Y+ MV+    ++ L     +G+IS FY    G+EG    A  A
Sbjct: 1   MEEREMPERER--LLDFYERMVRCMLWEQKLLRFIDEGKISGFYHAGRGQEGTQVGAVAA 58

Query: 531 LSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRGSGERETDAGPLRKQAPQHG 698
           L P D +   +R  G  + RGM +++     L    GS  R   AG +    PQ G
Sbjct: 59  LGPDDYMMYAHRGCGYMVARGMPMSKLFGDFLANTEGS-TRGLGAGIVHIAWPQLG 113


>UniRef50_Q9RYC1 Cluster: 2-oxo acid dehydrogenase, E1 component,
           alpha subunit; n=2; Deinococcus|Rep: 2-oxo acid
           dehydrogenase, E1 component, alpha subunit - Deinococcus
           radiodurans
          Length = 381

 Score = 43.6 bits (98), Expect = 0.005
 Identities = 20/43 (46%), Positives = 29/43 (67%)
 Frame = +1

Query: 610 LVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS*SIREHKLPP 738
           L++QC G+  D  +GRQMP H+ S+ HN V+ S SI   ++PP
Sbjct: 118 LISQCLGSNTDECRGRQMPHHFSSRAHNFVSASSSIAS-QVPP 159


>UniRef50_A3RZM3 Cluster: Pyruvate dehydrogenase E1 component alpha
           subunit; n=5; Proteobacteria|Rep: Pyruvate dehydrogenase
           E1 component alpha subunit - Ralstonia solanacearum
           UW551
          Length = 368

 Score = 43.6 bits (98), Expect = 0.005
 Identities = 21/74 (28%), Positives = 39/74 (52%)
 Frame = +3

Query: 390 TLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYRE 569
           TL+ +Y+ MV     D      QR G++  + ++ G+E I      A+  +D++F  YR+
Sbjct: 34  TLLALYRAMVLTRAFDTKAIALQRTGKLGTFASSVGQEAIGVGVASAMRAEDVLFPSYRD 93

Query: 570 VGVFLYRGMTVTET 611
               L RG+++ E+
Sbjct: 94  HSAQLLRGVSMAES 107


>UniRef50_P37940 Cluster: 2-oxoisovalerate dehydrogenase subunit
           alpha; n=37; Firmicutes|Rep: 2-oxoisovalerate
           dehydrogenase subunit alpha - Bacillus subtilis
          Length = 330

 Score = 43.6 bits (98), Expect = 0.005
 Identities = 25/85 (29%), Positives = 45/85 (52%), Gaps = 1/85 (1%)
 Frame = +3

Query: 357 DKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALS 536
           ++++   L     ++MY+TM+    +D+ ++   R G+I F ++  G+E     A  AL 
Sbjct: 4   NRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPFVISCQGQEAAQVGAAFALD 63

Query: 537 PK-DLVFSQYREVGVFLYRGMTVTE 608
            + D V   YR++GV L  GMT  +
Sbjct: 64  REMDYVLPYYRDMGVVLAFGMTAKD 88


>UniRef50_Q5SJR9 Cluster: Pyruvate dehydrogenase (Lipoamide) (EC
           1.2.4.1) E1-alpha chain; n=2; Thermus thermophilus|Rep:
           Pyruvate dehydrogenase (Lipoamide) (EC 1.2.4.1) E1-alpha
           chain - Thermus thermophilus (strain HB8 / ATCC 27634 /
           DSM 579)
          Length = 346

 Score = 42.7 bits (96), Expect = 0.009
 Identities = 24/83 (28%), Positives = 39/83 (46%)
 Frame = +3

Query: 354 IDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRAL 533
           +D+ E P  ++  L  +Y+ M +    D+     QRQGR+  Y    G+E        AL
Sbjct: 9   LDEGEFPLAEEEAL-RLYRAMRRARFFDEKALTLQRQGRLGVYAPFMGQEAAQVGVALAL 67

Query: 534 SPKDLVFSQYREVGVFLYRGMTV 602
             +D V   YRE  + L +G+ +
Sbjct: 68  EERDWVVPSYRESAMLLAKGLPI 90


>UniRef50_A6GB57 Cluster: Pyruvate dehydrogenase; n=1; Plesiocystis
           pacifica SIR-1|Rep: Pyruvate dehydrogenase -
           Plesiocystis pacifica SIR-1
          Length = 308

 Score = 42.7 bits (96), Expect = 0.009
 Identities = 36/137 (26%), Positives = 60/137 (43%)
 Frame = +3

Query: 300 TSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISF 479
           T++EP  +  ++D+ G + D      LD   L + YK +V    +D  L   +    +  
Sbjct: 4   TAWEPEGVEALLDSKGALADPAAVSGLD---LRSFYKQLVAARILDLKLGRLE----LPM 56

Query: 480 YMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRGSGERET 659
           +    GEE ++ A    +  +D VF   R+  V L RG+ +TE    +LR+L G    ET
Sbjct: 57  WAPAAGEEAVSVAVGSLVGEEDWVFVGNRDAAVALTRGLPLTE----ILRQLLGQASAET 112

Query: 660 DAGPLRKQAPQHGHNIL 710
               L        H ++
Sbjct: 113 RGRGLPGSLSSREHKLM 129


>UniRef50_A0M1U4 Cluster: 2-oxoisovalerate dehydrogenase E1
           component subunits alpha and beta; n=18;
           Bacteroidetes|Rep: 2-oxoisovalerate dehydrogenase E1
           component subunits alpha and beta - Gramella forsetii
           (strain KT0803)
          Length = 685

 Score = 42.7 bits (96), Expect = 0.009
 Identities = 23/102 (22%), Positives = 53/102 (51%), Gaps = 1/102 (0%)
 Frame = +3

Query: 288 FFNETSYEPIPIYRVMDNNGQIIDKN-EEPNLDKATLINMYKTMVQLSHMDKILYESQRQ 464
           FF+   +     Y ++ NN +      +E  L    ++++Y++M++   +++ +    RQ
Sbjct: 4   FFSLECFTDKQNYFMLSNNTKSRTMEYKETQLSNDAMLDLYRSMLKPRMIEEKMLILLRQ 63

Query: 465 GRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYR 590
           G+IS + +  G+E I+    ++L  ++ +   +R +GVF  R
Sbjct: 64  GKISKWFSGIGQEAISVGVTKSLETEEYILPMHRNLGVFTSR 105


>UniRef50_Q749T8 Cluster: Pyruvate dehydrogenase complex E1
           component, alpha subunit; n=4; Geobacter|Rep: Pyruvate
           dehydrogenase complex E1 component, alpha subunit -
           Geobacter sulfurreducens
          Length = 352

 Score = 42.3 bits (95), Expect = 0.012
 Identities = 25/77 (32%), Positives = 36/77 (46%)
 Frame = +3

Query: 372 PNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLV 551
           P+L    L  ++  M+     D+     QR+GRI  Y +  G+E     +  AL P D V
Sbjct: 29  PDLSGDQLRRLHYLMLLTRTFDRRALALQREGRIGTYPSVLGQEAAQVGSAFALQPSDWV 88

Query: 552 FSQYREVGVFLYRGMTV 602
           F  +RE+G  L  G  V
Sbjct: 89  FPSFREMGAHLTLGYPV 105


>UniRef50_Q49108 Cluster: Pyruvate dehydrogenase EI alpha subunit;
           n=5; Mollicutes|Rep: Pyruvate dehydrogenase EI alpha
           subunit - Mycoplasma capricolum
          Length = 370

 Score = 42.3 bits (95), Expect = 0.012
 Identities = 27/92 (29%), Positives = 43/92 (46%), Gaps = 1/92 (1%)
 Frame = +3

Query: 330 VMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGI 509
           V+D +G++I+    P +    ++  YK M      D      QRQGR+  ++++ G+E  
Sbjct: 17  VLDKDGKVINPKLMPKISDQEILEAYKIMNLSRRQDIYQNTMQRQGRLLSFLSSTGQEAC 76

Query: 510 T*AAPRALSPK-DLVFSQYREVGVFLYRGMTV 602
             A   AL+ K D   S YR    +L  G  V
Sbjct: 77  EVAYINALNKKTDHFVSGYRNNAAWLAMGQLV 108


>UniRef50_Q12FH4 Cluster: Pyruvate dehydrogenase; n=37;
           Bacteria|Rep: Pyruvate dehydrogenase - Polaromonas sp.
           (strain JS666 / ATCC BAA-500)
          Length = 337

 Score = 42.3 bits (95), Expect = 0.012
 Identities = 33/120 (27%), Positives = 57/120 (47%), Gaps = 2/120 (1%)
 Frame = +3

Query: 381 DKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIT*AAPRALSPKDLVFS 557
           DKA  + +   M+++  M++   +   + +I  ++  Y GEE +   A RAL P+D V +
Sbjct: 17  DKAFALAVLAGMLRIRRMEEKCAQLYGEQKIRGFLHLYIGEEAVAVGALRALQPQDNVVA 76

Query: 558 QYREVGVFLYRGMTVTETCEPVLRKLRGSGERETDAGPLRKQAPQ-HGHNILVH*GTQIA 734
            YRE G  L RG+ +      +  K  G       +  L  +A + +G N +V  G  +A
Sbjct: 77  TYREHGHALLRGLAMNGIMAEMYGKREGCSRGRGGSMHLFDRATRFYGGNAIVGGGLPLA 136


>UniRef50_A5IXN2 Cluster: Pyruvate dehydrogenase E1 component,
           alphasubunit; n=1; Mycoplasma agalactiae|Rep: Pyruvate
           dehydrogenase E1 component, alphasubunit - Mycoplasma
           agalactiae
          Length = 363

 Score = 41.1 bits (92), Expect = 0.028
 Identities = 25/98 (25%), Positives = 44/98 (44%)
 Frame = +3

Query: 309 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 488
           +P    R +D +G++I + +     K  L+ MYK M++    D      Q+ GR+  +  
Sbjct: 14  DPNETVRFLDVDGKLIQEFKPSAETKKKLVEMYKNMIRSRQWDLYSLTLQKTGRLGTFAP 73

Query: 489 NYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTV 602
             GEE         L+ +D     YR +   L RG+++
Sbjct: 74  ALGEEAALTGIGFNLNKEDWFIPHYRVLPTQLARGISM 111


>UniRef50_Q53610 Cluster: Branched-chain alpha-keto acid
           dehydrogenase E1-alpha subunit; n=16;
           Actinomycetales|Rep: Branched-chain alpha-keto acid
           dehydrogenase E1-alpha subunit - Streptomyces
           avermitilis
          Length = 406

 Score = 40.3 bits (90), Expect = 0.049
 Identities = 24/71 (33%), Positives = 32/71 (45%)
 Frame = +3

Query: 393 LINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREV 572
           L  +Y+ MV     D      QRQG +  + +  G+E     + RA    D VF  YRE 
Sbjct: 70  LRGLYRDMVLSRRFDAEATSLQRQGELGLWASMLGQEAAQIGSGRATRDDDYVFPTYREH 129

Query: 573 GVFLYRGMTVT 605
           GV   RG+  T
Sbjct: 130 GVAWCRGVDPT 140


>UniRef50_A0JY23 Cluster: Pyruvate dehydrogenase; n=2;
           Arthrobacter|Rep: Pyruvate dehydrogenase - Arthrobacter
           sp. (strain FB24)
          Length = 359

 Score = 40.3 bits (90), Expect = 0.049
 Identities = 24/68 (35%), Positives = 33/68 (48%), Gaps = 1/68 (1%)
 Frame = +3

Query: 378 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRAL-SPKDLVF 554
           L    L  +Y  MV + H+D      QRQG I  Y    G+E     +  A+ + +D VF
Sbjct: 30  LTAGQLRELYSLMVAVRHLDTSAIAWQRQGLIPGYAPELGQEAAQVGSGYAVDTARDFVF 89

Query: 555 SQYREVGV 578
             YRE+GV
Sbjct: 90  PTYREMGV 97


>UniRef50_Q8D6Q7 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
           complex, dehydrogenase component, eukaryotic type, alpha
           subunit; n=4; Vibrionaceae|Rep: Pyruvate/2-oxoglutarate
           dehydrogenase complex, dehydrogenase component,
           eukaryotic type, alpha subunit - Vibrio vulnificus
          Length = 364

 Score = 39.9 bits (89), Expect = 0.064
 Identities = 23/97 (23%), Positives = 44/97 (45%), Gaps = 1/97 (1%)
 Frame = +3

Query: 309 EPIPIYRVMDNNGQIIDKNEEPN-LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYM 485
           + +P++R +D  G +  ++  P+   +  L+  Y+ M+     D      QR G++  Y 
Sbjct: 4   QALPMHRFLDYEGNV--QSPLPSWASEERLVQFYRDMLITRAYDNKAVALQRTGKLGTYP 61

Query: 486 TNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596
           ++ G E        AL P D+    YR++     RG+
Sbjct: 62  SHLGSEAFGVGIGHALKPSDVFIPYYRDMPAMWVRGI 98


>UniRef50_Q83DQ6 Cluster: Dehydrogenase, E1 component, alpha
           subunit; n=3; Coxiella burnetii|Rep: Dehydrogenase, E1
           component, alpha subunit - Coxiella burnetii
          Length = 368

 Score = 39.9 bits (89), Expect = 0.064
 Identities = 22/93 (23%), Positives = 41/93 (44%), Gaps = 6/93 (6%)
 Frame = +3

Query: 348 QIIDKNEEPN------LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGI 509
           Q +D N  P        D   L+ +Y+ M  +  +D      QR G++  Y ++ G+E +
Sbjct: 17  QFLDANSNPTQPFPDFADPDMLLYLYRRMALIRQLDNKAINLQRTGKMGTYPSSRGQEAV 76

Query: 510 T*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608
                 A+  +D+    YR+ G     G+ ++E
Sbjct: 77  GIGMGSAMQKEDIFCPYYRDQGALFEHGIKLSE 109


>UniRef50_Q83FF2 Cluster: Pyruvate dehydrogenase E1 component alpha
           subunit; n=2; Tropheryma whipplei|Rep: Pyruvate
           dehydrogenase E1 component alpha subunit - Tropheryma
           whipplei (strain Twist) (Whipple's bacillus)
          Length = 370

 Score = 39.5 bits (88), Expect = 0.085
 Identities = 23/96 (23%), Positives = 44/96 (45%)
 Frame = +3

Query: 375 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVF 554
           +LD   +   Y+ ++ +  +D      QR+G ++ +   YG+E     A  A S  D++F
Sbjct: 33  SLDVEDIQRFYRDIILVRQIDHEAALLQRRGELALWPPVYGQEASQIGATYACSENDMIF 92

Query: 555 SQYREVGVFLYRGMTVTETCEPVLRKLRGSGERETD 662
             YR+  V   RG+ +      + +  RG+   + D
Sbjct: 93  PSYRDHAVMHARGIDLVH----IAKLFRGASNNDWD 124


>UniRef50_A6WG12 Cluster: Pyruvate dehydrogenase; n=3;
           Actinomycetales|Rep: Pyruvate dehydrogenase -
           Kineococcus radiotolerans SRS30216
          Length = 390

 Score = 39.5 bits (88), Expect = 0.085
 Identities = 23/76 (30%), Positives = 38/76 (50%)
 Frame = +3

Query: 369 EPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDL 548
           E +L+   L+ + + MV L  +D      QRQG++  +  + G+E     +  A   +D 
Sbjct: 39  EVDLEPEELLALLRDMVLLRRLDAEGEALQRQGQLGLWPGSRGQEAAQVGSATACRRQDQ 98

Query: 549 VFSQYREVGVFLYRGM 596
           VF  YR+ G  L RG+
Sbjct: 99  VFPSYRDHGAVLGRGI 114


>UniRef50_Q72GU1 Cluster: 2-oxoisovalerate dehydrogenase subunit
           alpha; n=2; Thermus thermophilus|Rep: 2-oxoisovalerate
           dehydrogenase subunit alpha - Thermus thermophilus
           (strain HB27 / ATCC BAA-163 / DSM 7039)
          Length = 367

 Score = 39.5 bits (88), Expect = 0.085
 Identities = 20/45 (44%), Positives = 25/45 (55%)
 Frame = +1

Query: 604 RKLVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTIS*SIREHKLPP 738
           ++L  Q      DP KGRQMP H GSK  N  T++  I  H +PP
Sbjct: 109 KELFGQMLATKADPNKGRQMPEHPGSKALNFFTVASPIASH-VPP 152


>UniRef50_Q5LVW0 Cluster: Dehydrogenase/transketolase family
           protein; n=23; Proteobacteria|Rep:
           Dehydrogenase/transketolase family protein -
           Silicibacter pomeroyi
          Length = 740

 Score = 38.7 bits (86), Expect = 0.15
 Identities = 21/77 (27%), Positives = 38/77 (49%)
 Frame = +3

Query: 372 PNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLV 551
           P L +A  +++Y+  V    +D+     Q+ G+  + + + G EG+  A  +AL P D+ 
Sbjct: 38  PGLTQAQAVSLYRAQVLSRALDRTSRAMQKAGQGFYTIGSSGHEGMA-AVAQALRPTDIA 96

Query: 552 FSQYREVGVFLYRGMTV 602
           F  YR+    + R   V
Sbjct: 97  FLHYRDAAFQIARAEQV 113


>UniRef50_Q9RPS5 Cluster: TPP-dependent branched-chain alpha-keto
           acid dehydrogenase, E1 alpha subunit; n=3;
           Lactobacillales|Rep: TPP-dependent branched-chain
           alpha-keto acid dehydrogenase, E1 alpha subunit -
           Enterococcus faecalis (Streptococcus faecalis)
          Length = 330

 Score = 38.3 bits (85), Expect = 0.20
 Identities = 17/29 (58%), Positives = 20/29 (68%), Gaps = 1/29 (3%)
 Frame = +1

Query: 625 YGNCEDPGK-GRQMPVHYGSKHHNMVTIS 708
           +G   DP   GRQMP HYGSK HN+V+ S
Sbjct: 94  FGKEADPSSHGRQMPNHYGSKEHNIVSFS 122


>UniRef50_Q7N5R1 Cluster: Similar to 3-methyl-2-oxobutanoate
           dehydrogenase; n=1; Photorhabdus luminescens subsp.
           laumondii|Rep: Similar to 3-methyl-2-oxobutanoate
           dehydrogenase - Photorhabdus luminescens subsp.
           laumondii
          Length = 665

 Score = 37.9 bits (84), Expect = 0.26
 Identities = 18/58 (31%), Positives = 32/58 (55%)
 Frame = +3

Query: 459 RQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRK 632
           RQGR  F+++  G EG+    P+ +   D++   YR+  + L RGM++ E    ++ K
Sbjct: 46  RQGRAWFHVSAAGHEGLA-VLPQLMEKNDVLVPYYRDRALVLARGMSIVEMTRELMGK 102


>UniRef50_Q3DYK5 Cluster: Dehydrogenase, E1 component; n=3;
           Bacteria|Rep: Dehydrogenase, E1 component - Chloroflexus
           aurantiacus J-10-fl
          Length = 321

 Score = 37.9 bits (84), Expect = 0.26
 Identities = 14/40 (35%), Positives = 26/40 (65%)
 Frame = +3

Query: 480 YMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMT 599
           Y +  G E ++ AA  +L P+D++   +R++G +L RG+T
Sbjct: 39  YFSQIGHEALSVAAALSLGPRDIIAPMHRDLGAYLVRGLT 78


>UniRef50_Q1IY28 Cluster: Pyruvate dehydrogenase; n=1; Deinococcus
           geothermalis DSM 11300|Rep: Pyruvate dehydrogenase -
           Deinococcus geothermalis (strain DSM 11300)
          Length = 361

 Score = 37.9 bits (84), Expect = 0.26
 Identities = 21/77 (27%), Positives = 35/77 (45%)
 Frame = +3

Query: 381 DKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQ 560
           D  T + +Y+ M +  H D+  +   R GR+  +    G E        AL+  D +F  
Sbjct: 36  DVPTRLKLYRLMRRARHFDERAWVLYRTGRMGVFPPYGGMEASQVGTAAALTHADWLFPT 95

Query: 561 YREVGVFLYRGMTVTET 611
           YR+ G  L  G+ + +T
Sbjct: 96  YRDTGAALTYGLPLEQT 112


>UniRef50_Q67SE7 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
           n=2; Bacilli|Rep: Pyruvate dehydrogenase E1 alpha
           subunit - Symbiobacterium thermophilum
          Length = 368

 Score = 37.5 bits (83), Expect = 0.34
 Identities = 27/110 (24%), Positives = 49/110 (44%), Gaps = 1/110 (0%)
 Frame = +3

Query: 318 PIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYG 497
           P+ R++  +G +++      L    L ++Y+ MV L   D+     QRQGR+  +    G
Sbjct: 15  PVRRILQADGTLLEP-VPAFLSVDQLKDVYRKMVYLRVFDQRCLNLQRQGRMGTFAPFSG 73

Query: 498 EEGIT*AAPRALSP-KDLVFSQYREVGVFLYRGMTVTETCEPVLRKLRGS 644
           +E     +   L P +D +F  YR+ G     G+ +       +   +GS
Sbjct: 74  QEASQVGSAYLLRPDRDWIFPTYRDHGAMHVMGVPLVNILRYFMGDEQGS 123


>UniRef50_P16387 Cluster: Pyruvate dehydrogenase E1 component
           subunit alpha, mitochondrial precursor; n=34;
           Dikarya|Rep: Pyruvate dehydrogenase E1 component subunit
           alpha, mitochondrial precursor - Saccharomyces
           cerevisiae (Baker's yeast)
          Length = 420

 Score = 37.5 bits (83), Expect = 0.34
 Identities = 36/120 (30%), Positives = 55/120 (45%), Gaps = 4/120 (3%)
 Frame = +3

Query: 384 KATLINMYKTMVQLSHMDKILYESQRQGRI-SFYMTNYGEEGIT*AAPRALSPKDLVFSQ 560
           KATL+ MYK MV +  M+       +  +I  F   + G+E I      A++  D + + 
Sbjct: 78  KATLLQMYKDMVIIRRMEMACDALYKAKKIRGFCHLSVGQEAIAVGIENAITKLDSIITS 137

Query: 561 YREVGVFLYRGMTVTETCEPVLRKLRG--SGERETDAGPLRKQAPQ-HGHNILVH*GTQI 731
           YR  G    RG +V    + VL +L G  +G      G +   AP  +G N +V  G Q+
Sbjct: 138 YRCHGFTFMRGASV----KAVLAELMGRRAGVSYGKGGSMHLYAPGFYGGNGIV--GAQV 191


>UniRef50_Q6A611 Cluster: Pyruvate dehydrogenase E1 component, alpha
           subunit; n=1; Propionibacterium acnes|Rep: Pyruvate
           dehydrogenase E1 component, alpha subunit -
           Propionibacterium acnes
          Length = 381

 Score = 37.1 bits (82), Expect = 0.45
 Identities = 29/119 (24%), Positives = 50/119 (42%), Gaps = 1/119 (0%)
 Frame = +3

Query: 255 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEP-NLDKATLINMYKTMVQLSH 431
           G   P+V   +       +P  + R++D  G++    + P +L    L+   + MV    
Sbjct: 10  GGTDPFVLPARQHPVNRPDPAMV-RILDEQGRLTTHPDFPVDLVDDDLVKALEMMVMTRR 68

Query: 432 MDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTE 608
           +D      QR G +  +    G+E     A  AL   D VF  YRE G+    G+++ +
Sbjct: 69  LDVEATALQRHGELGLWPPLLGQEATQAGAWLALREGDQVFPTYREQGLAHAMGVSLAD 127


>UniRef50_A4F1Y5 Cluster: Branched-chain alpha-keto acid
           decarboxylase; n=1; Streptomyces virginiae|Rep:
           Branched-chain alpha-keto acid decarboxylase -
           Streptomyces virginiae
          Length = 677

 Score = 37.1 bits (82), Expect = 0.45
 Identities = 19/58 (32%), Positives = 31/58 (53%)
 Frame = +3

Query: 459 RQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRK 632
           RQG+  F++++ G E +  A    L P+DL+F  YR+  + L RGM        ++ K
Sbjct: 57  RQGQAWFHISSAGHEALA-ALCELLEPEDLIFPHYRDRTLMLARGMDAEGQARDLMAK 113


>UniRef50_Q1EGI2 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
           n=6; Spirotrichea|Rep: Pyruvate dehydrogenase E1 alpha
           subunit - Euplotes sp. BB-2004
          Length = 389

 Score = 35.5 bits (78), Expect = 1.4
 Identities = 31/125 (24%), Positives = 58/125 (46%), Gaps = 4/125 (3%)
 Frame = +3

Query: 288 FFNETSYEPIPIYRVMDNNGQIIDKNEEPN---LDKATLINMYKTMVQLSHMDKILYESQ 458
           FF+ T    +P ++V       I+++E P      K+ L+N YK M  +  ++ +     
Sbjct: 22  FFSSTIEVELPKFKV-----HRIEESELPTKATTTKSELLNYYKDMALMRRVEIVSDMLY 76

Query: 459 RQGRISFYMTNY-GEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGMTVTETCEPVLRKL 635
           +   I  +   Y G+E IT     AL+ +D + + YR+    + RG T  E    ++++ 
Sbjct: 77  KNKWIRGFCHLYDGQESITVGMEAALTMEDHIINAYRDHTTAMGRGHTSYEIIAEMMQRS 136

Query: 636 RGSGE 650
            GS +
Sbjct: 137 TGSSK 141


>UniRef50_Q9HNV6 Cluster: Pyruvate dehydrogenase alpha subunit; n=1;
           Halobacterium salinarum|Rep: Pyruvate dehydrogenase
           alpha subunit - Halobacterium salinarium (Halobacterium
           halobium)
          Length = 322

 Score = 35.5 bits (78), Expect = 1.4
 Identities = 21/65 (32%), Positives = 32/65 (49%)
 Frame = +3

Query: 414 MVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRG 593
           MV+  H D+     QR+G +  Y    G+EG    A  AL+  D +F  YR   + L RG
Sbjct: 1   MVRARHFDERALALQRRGWMPGYPPFKGQEGSQVGAAHALAGDDWLFPTYRSNAMQLARG 60

Query: 594 MTVTE 608
           +  ++
Sbjct: 61  VPASD 65


>UniRef50_Q74AD3 Cluster: Dehydrogenase complex, E1 component, alpha
           subunit; n=5; Geobacter|Rep: Dehydrogenase complex, E1
           component, alpha subunit - Geobacter sulfurreducens
          Length = 325

 Score = 35.1 bits (77), Expect = 1.8
 Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 1/73 (1%)
 Frame = +3

Query: 378 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIT*AAPRALSPKDLVF 554
           L  + L+ M++ MV     ++   E   +G I+ ++  Y G+E +   A  AL   D + 
Sbjct: 9   LPDSELLKMHEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAALRKDDYIL 68

Query: 555 SQYREVGVFLYRG 593
           S YRE    + RG
Sbjct: 69  SAYREHAQAIVRG 81


>UniRef50_Q2BFQ9 Cluster: Putative uncharacterized protein; n=1;
           Bacillus sp. NRRL B-14911|Rep: Putative uncharacterized
           protein - Bacillus sp. NRRL B-14911
          Length = 668

 Score = 35.1 bits (77), Expect = 1.8
 Identities = 22/89 (24%), Positives = 45/89 (50%), Gaps = 1/89 (1%)
 Frame = +3

Query: 378 LDKATLINMYKTMVQLSHMDKILYESQRQGRI-SFYMTNYGEEGIT*AAPRALSPKDLVF 554
           L + T+ +MYK M+ +  +++ L +   +G +     T+ G+E    A+   +   D+VF
Sbjct: 14  LSQETIDSMYKKMITIRTLEETLLDLFSKGELFGTTHTSIGQEANAVASMAHIKNGDVVF 73

Query: 555 SQYREVGVFLYRGMTVTETCEPVLRKLRG 641
           S +R  G ++  G  V +    V+ ++ G
Sbjct: 74  SNHRCHGHYIAYGAPVDQLIAEVMGRVTG 102


>UniRef50_Q67ME6 Cluster: Branched-chain alpha-keto acid
           dehydrogenase E1 alpha subunit; n=23; Bacteria|Rep:
           Branched-chain alpha-keto acid dehydrogenase E1 alpha
           subunit - Symbiobacterium thermophilum
          Length = 352

 Score = 34.7 bits (76), Expect = 2.4
 Identities = 32/116 (27%), Positives = 49/116 (42%), Gaps = 1/116 (0%)
 Frame = +3

Query: 360 KNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSP 539
           ++E   L    +  MY  M+    +D+ L+  QR G+I F ++  G+E     A  A   
Sbjct: 26  RHEALGLTADQVREMYYYMLLTRRLDERLWLLQRGGKIPFVISPQGQEAAQVGAAFAFRR 85

Query: 540 K-DLVFSQYREVGVFLYRGMTVTETCEPVLRKLRGSGERETDAGPLRKQAPQHGHN 704
           + D     YR++GV L  G+T  E        +  +  R  D     KQ P H  N
Sbjct: 86  RQDWFTPYYRDLGVNLVVGVTPREV-------MLSAFARGADPASGGKQMPSHWGN 134


>UniRef50_Q479Q2 Cluster: Dehydrogenase, E1 component; n=2;
           Rhodocyclaceae|Rep: Dehydrogenase, E1 component -
           Dechloromonas aromatica (strain RCB)
          Length = 320

 Score = 34.7 bits (76), Expect = 2.4
 Identities = 17/66 (25%), Positives = 30/66 (45%)
 Frame = +3

Query: 396 INMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVG 575
           + +Y+ ++ +   +  +      GRI    T+ G+E     A  AL   DL+ + +R  G
Sbjct: 11  LRLYEQLLLIRAYENAIVRGSTDGRIPGTCTSVGQEAAAVGAINALEADDLILTNHRSAG 70

Query: 576 VFLYRG 593
             L RG
Sbjct: 71  HLLARG 76


>UniRef50_Q02C52 Cluster: Pyruvate dehydrogenase; n=1; Solibacter
           usitatus Ellin6076|Rep: Pyruvate dehydrogenase -
           Solibacter usitatus (strain Ellin6076)
          Length = 340

 Score = 34.7 bits (76), Expect = 2.4
 Identities = 20/81 (24%), Positives = 38/81 (46%), Gaps = 1/81 (1%)
 Frame = +3

Query: 402 MYKTMVQLSHMDKILYESQRQGRI-SFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGV 578
           +Y  ++     D+I  +  RQG+I        G+E I   +     P+D++F  +R++ V
Sbjct: 30  LYYMLLMREVEDRIERKLYRQGKILGGVYVGRGQEAIPVGSALVAVPEDVMFPSHRDMAV 89

Query: 579 FLYRGMTVTETCEPVLRKLRG 641
           F  RG++        + +L G
Sbjct: 90  FFIRGVSARRVLAQYMGRLGG 110


>UniRef50_A0LSF3 Cluster: Pyruvate dehydrogenase; n=5; Bacteria|Rep:
           Pyruvate dehydrogenase - Acidothermus cellulolyticus
           (strain ATCC 43068 / 11B)
          Length = 375

 Score = 34.7 bits (76), Expect = 2.4
 Identities = 20/65 (30%), Positives = 32/65 (49%), Gaps = 1/65 (1%)
 Frame = +3

Query: 405 YKTMVQLSHMDKILYESQRQGRISFYM-TNYGEEGIT*AAPRALSPKDLVFSQYREVGVF 581
           Y+ M  +   ++   E  ++ +I  Y   N GEE        A++P D +F+ YRE G  
Sbjct: 45  YRMMQLIRRFEERAAEMYQRAKIGGYCHLNLGEEATVVGLMDAMAPHDYLFTTYREHGYA 104

Query: 582 LYRGM 596
           L RG+
Sbjct: 105 LARGI 109


>UniRef50_Q8YNY8 Cluster: Asr4421 protein; n=1; Nostoc sp. PCC
           7120|Rep: Asr4421 protein - Anabaena sp. (strain PCC
           7120)
          Length = 71

 Score = 33.9 bits (74), Expect = 4.2
 Identities = 16/38 (42%), Positives = 24/38 (63%)
 Frame = -3

Query: 185 FTIFVIDLFLTSLLLTSIACFQKSNTKVYDCTDSRKYC 72
           F ++   +FL  +L+TS+   +KSNT V+  T S KYC
Sbjct: 26  FMVYAKSIFL-KVLMTSVYSLKKSNTYVFTVTYSGKYC 62


>UniRef50_A6DTS3 Cluster: Dehydrogenase complex, E1 component, alpha
           subunit; n=1; Lentisphaera araneosa HTCC2155|Rep:
           Dehydrogenase complex, E1 component, alpha subunit -
           Lentisphaera araneosa HTCC2155
          Length = 320

 Score = 33.9 bits (74), Expect = 4.2
 Identities = 22/90 (24%), Positives = 41/90 (45%), Gaps = 1/90 (1%)
 Frame = +3

Query: 375 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIT*AAPRALSPKDLV 551
           N+ K   + M + M+++   ++   +S +Q  I+ +   Y G+E +   A   L+P D  
Sbjct: 3   NIGKEKALQMLEQMIRVRRFEEGCLKSYQQKFITGFCHTYIGQEAVAVGAMAHLTPTDAY 62

Query: 552 FSQYREVGVFLYRGMTVTETCEPVLRKLRG 641
            + YR     L  G+T  E    +  K+ G
Sbjct: 63  VTSYRCHAQGLIGGLTSREVMAEMFGKITG 92


>UniRef50_Q8ZUR8 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
           n=3; Pyrobaculum|Rep: Pyruvate dehydrogenase E1 alpha
           subunit - Pyrobaculum aerophilum
          Length = 372

 Score = 33.9 bits (74), Expect = 4.2
 Identities = 25/102 (24%), Positives = 45/102 (44%), Gaps = 2/102 (1%)
 Frame = +3

Query: 297 ETSYEPIPIYRVMDNNGQIIDKNEEP-NLDKATLINMYKTMVQLSHMDKILYESQRQGRI 473
           +T  +   ++RV+  +G  ++  E      +  L   Y+ MV    +D+      R G++
Sbjct: 13  KTEVKEPQVFRVLGQDGSPLETYEVGYKPSEGELAKAYRWMVLGRVLDRYALMYHRMGKV 72

Query: 474 -SFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596
            S Y  + G E        AL P+D V   YR + + + RG+
Sbjct: 73  KSTYGPHEGHEAADAGTALALRPEDWVAPYYRNLTLLIARGV 114


>UniRef50_Q2JA37 Cluster: Pyruvate dehydrogenase; n=11;
           Actinomycetales|Rep: Pyruvate dehydrogenase - Frankia
           sp. (strain CcI3)
          Length = 388

 Score = 33.1 bits (72), Expect = 7.4
 Identities = 16/46 (34%), Positives = 24/46 (52%)
 Frame = +3

Query: 459 RQGRISFYMTNYGEEGIT*AAPRALSPKDLVFSQYREVGVFLYRGM 596
           RQGR++ Y  + G+E    AA   L   D +F  YR+    + RG+
Sbjct: 73  RQGRLAVYPASTGQEACQIAAAMVLRESDWLFPSYRDTLAVVSRGV 118


>UniRef50_A7GY08 Cluster: Ferric uptake regulation protein; n=2;
           Campylobacter|Rep: Ferric uptake regulation protein -
           Campylobacter curvus 525.92
          Length = 147

 Score = 33.1 bits (72), Expect = 7.4
 Identities = 16/46 (34%), Positives = 27/46 (58%)
 Frame = -2

Query: 177 ICYRSFSHITTFDIDSLFSKIQYKSLRLH*FSKILLFIQNSTLCSS 40
           I YRS +H++  DI + FSKI  +++ L     +L F+    LC++
Sbjct: 32  ILYRSQTHLSAQDIQTEFSKIHAQNISLPTIYALLNFLDECRLCNT 77


>UniRef50_A3S1N4 Cluster: Putative uncharacterized protein; n=1;
           Prochlorococcus marinus str. MIT 9211|Rep: Putative
           uncharacterized protein - Prochlorococcus marinus str.
           MIT 9211
          Length = 263

 Score = 33.1 bits (72), Expect = 7.4
 Identities = 17/51 (33%), Positives = 26/51 (50%)
 Frame = -3

Query: 173 VIDLFLTSLLLTSIACFQKSNTKVYDCTDSRKYCCSYKIQLYVHPSSPSKS 21
           ++DL  TS LL   A F+   T++ + +   + CC Y I L +    PS S
Sbjct: 12  LLDLSKTSQLLAIKAEFEAEGTRIEELSVLSQLCCKYSIPLTLKVGGPSAS 62


>UniRef50_Q1XDM0 Cluster: Pyruvate dehydrogenase E1 component
           subunit alpha; n=52; cellular organisms|Rep: Pyruvate
           dehydrogenase E1 component subunit alpha - Porphyra
           yezoensis
          Length = 346

 Score = 33.1 bits (72), Expect = 7.4
 Identities = 17/66 (25%), Positives = 38/66 (57%), Gaps = 1/66 (1%)
 Frame = +3

Query: 375 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIT*AAPRALSPKDLV 551
           NL+K+ L+ +Y+ M+   + + +  +   +G++  ++  Y G+E ++    + L+P D V
Sbjct: 20  NLNKSNLLVLYEDMLLGRNFEDMCAQMYYKGKMFGFVHLYNGQEAVSTGVIKLLNPTDYV 79

Query: 552 FSQYRE 569
            S YR+
Sbjct: 80  CSTYRD 85


>UniRef50_Q5DY55 Cluster: Putative uncharacterized protein; n=1;
           Vibrio fischeri ES114|Rep: Putative uncharacterized
           protein - Vibrio fischeri (strain ATCC 700601 / ES114)
          Length = 147

 Score = 32.7 bits (71), Expect = 9.7
 Identities = 20/52 (38%), Positives = 29/52 (55%), Gaps = 1/52 (1%)
 Frame = +3

Query: 342 NGQIIDKNEEPNLDKATLINMY-KTMVQLSHMDKILYESQRQGRISFYMTNY 494
           N  II K EE ++DK  LI +Y KT   L+ + K ++ S R G +S    N+
Sbjct: 76  NKTIIVKKEERSVDKQKLIFLYKKTSNNLNQLAKQIHTSNRAGTLSREKMNH 127


  Database: uniref50
    Posted date:  Oct 5, 2007 11:19 AM
  Number of letters in database: 575,637,011
  Number of sequences in database:  1,657,284
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 808,290,510
Number of Sequences: 1657284
Number of extensions: 17325550
Number of successful extensions: 45983
Number of sequences better than 10.0: 90
Number of HSP's better than 10.0 without gapping: 44241
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 45959
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 60500186565
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)

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