Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= tesV0336.Seq
(741 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9VHB8 Cluster: CG8199-PA; n=2; Eukaryota|Rep: CG8199-P... 168 1e-40
UniRef50_Q295J7 Cluster: GA20891-PA; n=7; Coelomata|Rep: GA20891... 166 6e-40
UniRef50_Q4A1S8 Cluster: Putative uncharacterized protein; n=4; ... 163 4e-39
UniRef50_P12694 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 160 4e-38
UniRef50_A7RZV6 Cluster: Predicted protein; n=6; Eumetazoa|Rep: ... 156 5e-37
UniRef50_Q9LPL5 Cluster: Branched-chain alpha keto-acid dehydrog... 145 9e-34
UniRef50_A0DAM1 Cluster: Chromosome undetermined scaffold_43, wh... 130 3e-29
UniRef50_A6RV39 Cluster: Putative uncharacterized protein; n=1; ... 125 1e-27
UniRef50_Q4DB65 Cluster: 2-oxoisovalerate dehydrogenase alpha su... 123 5e-27
UniRef50_Q5KGR5 Cluster: Branched-chain alpha-keto acid dehydrog... 116 6e-25
UniRef50_Q4P2J0 Cluster: Putative uncharacterized protein; n=1; ... 111 1e-23
UniRef50_Q4Y3F8 Cluster: Branched-chain alpha keto-acid dehydrog... 110 4e-23
UniRef50_Q4QC52 Cluster: 2-oxoisovalerate dehydrogenase alpha su... 105 1e-21
UniRef50_Q5QUK4 Cluster: Alpha keto acid dehydrogenase complex, ... 103 6e-21
UniRef50_Q1KSF2 Cluster: Mitochondrial branched-chain alpha-keto... 102 1e-20
UniRef50_Q9YBC0 Cluster: Pyruvate dehydrogenase E1 component, al... 83 7e-15
UniRef50_A7HBV0 Cluster: 3-methyl-2-oxobutanoate dehydrogenase; ... 82 2e-14
UniRef50_Q4N1L6 Cluster: Branched-chain alpha keto-acid dehydrog... 81 4e-14
UniRef50_Q6YPX5 Cluster: Thiamine pyrophosphate-dependent dehydr... 79 1e-13
UniRef50_P35485 Cluster: Pyruvate dehydrogenase E1 component sub... 70 5e-11
UniRef50_O48615 Cluster: Alpha-keto acid dehydrogenase-like prot... 66 6e-10
UniRef50_Q97CK0 Cluster: 2-oxoisovalerate dehydrogenase alpha su... 66 9e-10
UniRef50_Q9RPS5 Cluster: TPP-dependent branched-chain alpha-keto... 63 8e-09
UniRef50_Q9HN77 Cluster: Pyruvate dehydrogenase alpha subunit; n... 63 8e-09
UniRef50_P09060 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 61 2e-08
UniRef50_P37940 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 61 2e-08
UniRef50_Q9RYC1 Cluster: 2-oxo acid dehydrogenase, E1 component,... 60 6e-08
UniRef50_A0M1U4 Cluster: 2-oxoisovalerate dehydrogenase E1 compo... 59 1e-07
UniRef50_Q67ME6 Cluster: Branched-chain alpha-keto acid dehydrog... 58 2e-07
UniRef50_Q4L1A7 Cluster: Pyruvate dehydrogenase E1 component alp... 57 4e-07
UniRef50_Q5KUY4 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 54 3e-06
UniRef50_P47516 Cluster: Pyruvate dehydrogenase E1 component sub... 54 3e-06
UniRef50_Q72GU1 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 54 5e-06
UniRef50_Q020J5 Cluster: Dehydrogenase, E1 component; n=1; Solib... 53 6e-06
UniRef50_Q8CX87 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 52 1e-05
UniRef50_Q8EVQ2 Cluster: Pyruvate dehydrogenase E1 component sub... 50 5e-05
UniRef50_Q7N5R1 Cluster: Similar to 3-methyl-2-oxobutanoate dehy... 50 5e-05
UniRef50_A1UJ85 Cluster: Pyruvate dehydrogenase; n=16; Mycobacte... 50 8e-05
UniRef50_Q1IQR3 Cluster: Dehydrogenase, E1 component; n=1; Acido... 49 1e-04
UniRef50_A6GB57 Cluster: Pyruvate dehydrogenase; n=1; Plesiocyst... 48 2e-04
UniRef50_A6CP23 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 48 2e-04
UniRef50_Q0W151 Cluster: Pyruvate dehydrogenase complex E1, tran... 48 2e-04
UniRef50_Q6L1L8 Cluster: Pyruvate dehydrogenase E1 component alp... 46 0.001
UniRef50_Q835M4 Cluster: Pyruvate dehydrogenase complex E1 compo... 45 0.002
UniRef50_P21873 Cluster: Pyruvate dehydrogenase E1 component sub... 45 0.002
UniRef50_Q7NLM8 Cluster: Gll1094 protein; n=1; Gloeobacter viola... 44 0.004
UniRef50_Q6MAE2 Cluster: Putative pyruvate dehydrogenase (Lipoam... 44 0.004
UniRef50_A0LLM4 Cluster: Pyruvate dehydrogenase; n=1; Syntrophob... 44 0.005
UniRef50_A5IXN2 Cluster: Pyruvate dehydrogenase E1 component, al... 43 0.007
UniRef50_A5UU15 Cluster: Pyruvate dehydrogenase; n=3; Chloroflex... 40 0.049
UniRef50_A7D3P2 Cluster: Pyruvate dehydrogenase; n=1; Halorubrum... 40 0.049
UniRef50_A0K283 Cluster: Pyruvate dehydrogenase; n=4; Actinobact... 40 0.064
UniRef50_Q49108 Cluster: Pyruvate dehydrogenase EI alpha subunit... 39 0.11
UniRef50_Q8ZUR8 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 39 0.11
UniRef50_Q9KG99 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 38 0.20
UniRef50_Q5SJR9 Cluster: Pyruvate dehydrogenase (Lipoamide) (EC ... 38 0.20
UniRef50_Q1LFS5 Cluster: Dehydrogenase, E1 component; n=22; Prot... 38 0.26
UniRef50_A5UVY9 Cluster: Pyruvate dehydrogenase; n=2; Roseiflexu... 38 0.26
UniRef50_UPI00005103B4 Cluster: COG1071: Pyruvate/2-oxoglutarate... 37 0.60
UniRef50_Q4MTG0 Cluster: Pyruvate dehydrogenase E1 component sub... 37 0.60
UniRef50_Q5VGY4 Cluster: Pyruvate dehydrogenase alpha subunit; n... 36 1.4
UniRef50_Q12FH4 Cluster: Pyruvate dehydrogenase; n=37; Bacteria|... 35 1.8
UniRef50_Q8YNY8 Cluster: Asr4421 protein; n=1; Nostoc sp. PCC 71... 34 4.2
UniRef50_A7CXZ4 Cluster: Pyruvate dehydrogenase; n=1; Opitutacea... 33 5.6
UniRef50_A3ZN48 Cluster: Putative uncharacterized protein; n=1; ... 33 5.6
UniRef50_Q53610 Cluster: Branched-chain alpha-keto acid dehydrog... 33 7.4
UniRef50_A7GY08 Cluster: Ferric uptake regulation protein; n=2; ... 33 7.4
UniRef50_A3S1N4 Cluster: Putative uncharacterized protein; n=1; ... 33 7.4
UniRef50_A0JUQ5 Cluster: Pyruvate dehydrogenase; n=4; Actinobact... 33 7.4
UniRef50_Q5DY55 Cluster: Putative uncharacterized protein; n=1; ... 33 9.7
UniRef50_Q2J998 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp... 33 9.7
UniRef50_Q02C52 Cluster: Pyruvate dehydrogenase; n=1; Solibacter... 33 9.7
UniRef50_A3EK78 Cluster: Putative uncharacterized protein; n=1; ... 33 9.7
UniRef50_O64493 Cluster: F20D22.9 protein; n=5; Magnoliophyta|Re... 33 9.7
UniRef50_A2FMN4 Cluster: ImpB/MucB/SamB family protein; n=1; Tri... 33 9.7
>UniRef50_Q9VHB8 Cluster: CG8199-PA; n=2; Eukaryota|Rep: CG8199-PA -
Drosophila melanogaster (Fruit fly)
Length = 439
Score = 168 bits (408), Expect = 1e-40
Identities = 80/152 (52%), Positives = 105/152 (69%), Gaps = 2/152 (1%)
Frame = +3
Query: 255 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHM 434
GA+AP+VS++ Y PIPIYRVMD +G I D+ ++P L + + M++ MV L+ M
Sbjct: 48 GAKAPFVSKLNLIQPEDYAPIPIYRVMDQDGYIADETQDPQLGREVVEKMFRDMVLLNTM 107
Query: 435 DKILYESQRQGRISFYMTNYGEEG--IT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTE 608
DKILYESQRQGRISFYMTN+GEE I AA I+ QYRE GV ++RG + +
Sbjct: 108 DKILYESQRQGRISFYMTNFGEEASHIGSAAALEMRDLIYG--QYREAGVLVWRGFRIDQ 165
Query: 609 LVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTI 704
++QCYGN +D G+G+QMPVHYGS+ N VTI
Sbjct: 166 FIDQCYGNTDDLGRGKQMPVHYGSRELNFVTI 197
>UniRef50_Q295J7 Cluster: GA20891-PA; n=7; Coelomata|Rep: GA20891-PA
- Drosophila pseudoobscura (Fruit fly)
Length = 439
Score = 166 bits (403), Expect = 6e-40
Identities = 80/152 (52%), Positives = 106/152 (69%), Gaps = 2/152 (1%)
Frame = +3
Query: 255 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHM 434
GA+AP+VS++K Y PIPIYRVMD +G I D+ ++P L + + M++ M+ L+ M
Sbjct: 48 GAKAPFVSKLKLNMPEDYAPIPIYRVMDRDGFIADETQDPQLGREVVEKMFRDMLLLNTM 107
Query: 435 DKILYESQRQGRISFYMTNYGEEG--IT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTE 608
DKILYESQRQGRISFYMTN+GEE I AA I+ QYRE GV ++RG + +
Sbjct: 108 DKILYESQRQGRISFYMTNFGEEASHIGSAAALEMRDLIYG--QYREAGVLVWRGFRIDQ 165
Query: 609 LVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTI 704
++QCYGN +D G+G+QMPVHYGS+ N VTI
Sbjct: 166 FIDQCYGNVDDLGRGKQMPVHYGSRELNFVTI 197
>UniRef50_Q4A1S8 Cluster: Putative uncharacterized protein; n=4;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 432
Score = 163 bits (396), Expect = 4e-39
Identities = 77/150 (51%), Positives = 104/150 (69%), Gaps = 2/150 (1%)
Frame = +3
Query: 261 RAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDK 440
+A + +++ N +PIYRV + G +IDK+++PN D+ T + MYKTM QL+ MD+
Sbjct: 42 KAAFTEKLEIVNADDTPALPIYRVTNAVGDVIDKSQDPNFDEQTSLKMYKTMTQLNIMDR 101
Query: 441 ILYESQRQGRISFYMTNYGEEG--IT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELV 614
ILY+SQRQGRISFYMT++GEEG + AA I+ QYRE GV L+RG T+ +
Sbjct: 102 ILYDSQRQGRISFYMTSFGEEGNHVGSAAALEPQDLIYG--QYREAGVLLWRGYTMENFM 159
Query: 615 NQCYGNCEDPGKGRQMPVHYGSKHHNMVTI 704
NQCYGN +D GKGRQMP+H+G+K N VTI
Sbjct: 160 NQCYGNADDLGKGRQMPMHFGTKERNFVTI 189
>UniRef50_P12694 Cluster: 2-oxoisovalerate dehydrogenase subunit
alpha, mitochondrial precursor; n=29; Euteleostomi|Rep:
2-oxoisovalerate dehydrogenase subunit alpha,
mitochondrial precursor - Homo sapiens (Human)
Length = 445
Score = 160 bits (388), Expect = 4e-38
Identities = 77/150 (51%), Positives = 97/150 (64%)
Frame = +3
Query: 255 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHM 434
GA A ++ +++F IPIYRVMD GQII+ +E+P+L K ++ +YK+M L+ M
Sbjct: 56 GASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTM 115
Query: 435 DKILYESQRQGRISFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELV 614
D+ILYESQRQGRISFYMTNYGEEG + QYRE GV +YR + +
Sbjct: 116 DRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFM 175
Query: 615 NQCYGNCEDPGKGRQMPVHYGSKHHNMVTI 704
QCYGN D GKGRQMPVHYG K + VTI
Sbjct: 176 AQCYGNISDLGKGRQMPVHYGCKERHFVTI 205
>UniRef50_A7RZV6 Cluster: Predicted protein; n=6; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 444
Score = 156 bits (379), Expect = 5e-37
Identities = 73/130 (56%), Positives = 90/130 (69%)
Frame = +3
Query: 315 IPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY 494
IP+YRVMD G+II + +P L + T+++MYK M L+ MD+ILYESQRQGRISFYMTNY
Sbjct: 74 IPVYRVMDRQGKIIIDSHDPKLPEGTIVDMYKKMTLLNTMDRILYESQRQGRISFYMTNY 133
Query: 495 GEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHY 674
GEE + + QYRE GV ++RG T+ + +NQCY N D GKGRQMPVHY
Sbjct: 134 GEEATHFGSAAALEMEDLIMGQYREAGVLMWRGFTLADFMNQCYANQHDAGKGRQMPVHY 193
Query: 675 GSKHHNMVTI 704
GSK N VTI
Sbjct: 194 GSKELNFVTI 203
>UniRef50_Q9LPL5 Cluster: Branched-chain alpha keto-acid
dehydrogenase E1-alpha subunit; n=13; Magnoliophyta|Rep:
Branched-chain alpha keto-acid dehydrogenase E1-alpha
subunit - Arabidopsis thaliana (Mouse-ear cress)
Length = 472
Score = 145 bits (352), Expect = 9e-34
Identities = 73/150 (48%), Positives = 92/150 (61%)
Frame = +3
Query: 255 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHM 434
G + Y SEMKF E+S IP YRV+D +G+II ++ + + + MY+ M L M
Sbjct: 84 GGKVGYTSEMKFIPESSSRRIPCYRVLDEDGRIIPDSDFIPVSEKLAVRMYEQMATLQVM 143
Query: 435 DKILYESQRQGRISFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELV 614
D I YE+QRQGRISFY+T+ GEE I A+ QYRE GV L+RG T+ E
Sbjct: 144 DHIFYEAQRQGRISFYLTSVGEEAINIASAAALSPDDVVLPQYREPGVLLWRGFTLEEFA 203
Query: 615 NQCYGNCEDPGKGRQMPVHYGSKHHNMVTI 704
NQC+GN D GKGRQMP+HYGS N TI
Sbjct: 204 NQCFGNKADYGKGRQMPIHYGSNRLNYFTI 233
>UniRef50_A0DAM1 Cluster: Chromosome undetermined scaffold_43, whole
genome shotgun sequence; n=3; Oligohymenophorea|Rep:
Chromosome undetermined scaffold_43, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 406
Score = 130 bits (315), Expect = 3e-29
Identities = 63/134 (47%), Positives = 87/134 (64%)
Frame = +3
Query: 303 SYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFY 482
++EPI +RV+D G ++ K E N+ K L ++ M+ + MD +LY SQRQG+ISFY
Sbjct: 30 NFEPIKQFRVIDLEGNLVAK-EYNNIPKEILNQIFDLMISIEEMDNLLYMSQRQGKISFY 88
Query: 483 MTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQM 662
MT++GE T + + QYRE G F++RG T+ ++VNQC GN D GKGRQM
Sbjct: 89 MTSFGETATTVGTTAALQPQDFIFPQYREQGSFMWRGFTIEQIVNQCIGNHLDGGKGRQM 148
Query: 663 PVHYGSKHHNMVTI 704
PVHYGSK N+VT+
Sbjct: 149 PVHYGSKDLNIVTV 162
>UniRef50_A6RV39 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 211
Score = 125 bits (302), Expect = 1e-27
Identities = 69/155 (44%), Positives = 97/155 (62%), Gaps = 3/155 (1%)
Frame = +3
Query: 246 RISGA-RAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQ 422
R GA + + S + F + ++Y IP YR M +G+I+D + D+A L MY M++
Sbjct: 52 RFPGAVDSKFTSSLSFEHPSTYNAIPTYRTMSPDGEILDPSAVLPSDEAAL-EMYLNMIK 110
Query: 423 LSHMDKILYESQRQGRISFYMTNYGEEG--IT*AAPRHSHRKIWSSVQYREVGVFLYRGM 596
+S MD I+ E+QRQGR+SFYM + GEEG + AA I+S QYRE GVF+ RG
Sbjct: 111 VSIMDVIMVEAQRQGRLSFYMPSQGEEGTCVGSAAALEKDDVIFS--QYREAGVFMQRGF 168
Query: 597 TVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVT 701
T+ E ++Q + N +D GK R MPVHYGSK N+V+
Sbjct: 169 TLDEFMSQLFANRKDKGKARNMPVHYGSKELNIVS 203
>UniRef50_Q4DB65 Cluster: 2-oxoisovalerate dehydrogenase alpha
subunit, putative; n=3; Trypanosoma|Rep:
2-oxoisovalerate dehydrogenase alpha subunit, putative -
Trypanosoma cruzi
Length = 431
Score = 123 bits (296), Expect = 5e-27
Identities = 60/143 (41%), Positives = 87/143 (60%)
Frame = +3
Query: 267 PYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKIL 446
P V E+ F ++ Y P++ V+D +G++++ +EP + K TLI M + M++ +D IL
Sbjct: 45 PTVDELTF-HQRKYPSTPMFHVLDLDGRVVNPKQEPEVPKETLIKMMEAMLRQQSIDLIL 103
Query: 447 YESQRQGRISFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCY 626
E+QRQGRISFYMT+ GEE + +QYRE YRG TV ++V QC
Sbjct: 104 MEAQRQGRISFYMTSMGEEASAVGTAAALDMRDELFLQYREAAALTYRGYTVKDMVAQCM 163
Query: 627 GNCEDPGKGRQMPVHYGSKHHNM 695
G E+ KGRQMP+HYGS+ N+
Sbjct: 164 GTIENELKGRQMPIHYGSRALNV 186
>UniRef50_Q5KGR5 Cluster: Branched-chain alpha-keto acid
dehydrogenase E1-alpha subunit, putative; n=2;
Filobasidiella neoformans|Rep: Branched-chain alpha-keto
acid dehydrogenase E1-alpha subunit, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 504
Score = 116 bits (279), Expect = 6e-25
Identities = 62/146 (42%), Positives = 88/146 (60%), Gaps = 3/146 (2%)
Frame = +3
Query: 276 SEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYES 455
+EM +FN + + IP +RV+D G ++ E K +++Y+TM + +D +LY+S
Sbjct: 97 AEMGWFNAVA-KTIPTFRVLDEEGHMVKDGHESQATKEQTLSIYRTMTLIPIVDNVLYQS 155
Query: 456 QRQGRISFYMTNYGEEG--IT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYG 629
QRQGRISFYM GEE + AA ++ +I+ QYRE L+RG T+ L+ QC+G
Sbjct: 156 QRQGRISFYMQCAGEEAAIVGSAAAMLANDEIFG--QYRESAALLHRGFTLDALMAQCFG 213
Query: 630 NCEDPG-KGRQMPVHYGSKHHNMVTI 704
N +D G KGR MPVHY S H TI
Sbjct: 214 NVDDKGTKGRMMPVHYSSPEHGFHTI 239
>UniRef50_Q4P2J0 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 786
Score = 111 bits (268), Expect = 1e-23
Identities = 58/139 (41%), Positives = 82/139 (58%), Gaps = 2/139 (1%)
Frame = +3
Query: 294 NETSYEPIPIYRVMDNNGQIID--KNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQG 467
N+ S IP YR+MD G+++ E N+ + + MY+TM+ L +D ILY +QRQG
Sbjct: 390 NKNSQGGIPTYRLMDGVGRLLPGVTQEMINITQQEAVKMYRTMLLLPQIDVILYNAQRQG 449
Query: 468 RISFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPG 647
RISF MT+YGEEG + K QYRE GV L+R ++ ++Q +G +D
Sbjct: 450 RISFMMTSYGEEGAVIGSAAGLDAKDEVFAQYRESGVLLWRDFSIDHFMSQVFGAEDDLC 509
Query: 648 KGRQMPVHYGSKHHNMVTI 704
GRQMP+H+GS H+ TI
Sbjct: 510 GGRQMPIHFGSTQHHFHTI 528
>UniRef50_Q4Y3F8 Cluster: Branched-chain alpha keto-acid
dehydrogenase, putative; n=7; Plasmodium|Rep:
Branched-chain alpha keto-acid dehydrogenase, putative -
Plasmodium chabaudi
Length = 432
Score = 110 bits (264), Expect = 4e-23
Identities = 59/146 (40%), Positives = 87/146 (59%), Gaps = 1/146 (0%)
Frame = +3
Query: 270 YVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILY 449
+ +++K NE + +PI+R++D NG ++D + P D ++N+YK MV+ S D+I Y
Sbjct: 48 FSTDLKTVNEVA--KLPIFRILDTNGNLLDGHTAP-FDDEEVLNLYKQMVEFSIWDEIFY 104
Query: 450 ESQRQGRISFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYG 629
QRQGRISFY+ N GEEG+ + QYRE G+ L RG T +++NQ +G
Sbjct: 105 GIQRQGRISFYIVNDGEEGLHFGIGKALTVDDHLYCQYRETGILLSRGFTYEDILNQLFG 164
Query: 630 -NCEDPGKGRQMPVHYGSKHHNMVTI 704
+D GKGRQM + Y K N+ TI
Sbjct: 165 TKYDDEGKGRQMCICYTKKDLNIHTI 190
>UniRef50_Q4QC52 Cluster: 2-oxoisovalerate dehydrogenase alpha
subunit, putative; n=3; Leishmania|Rep: 2-oxoisovalerate
dehydrogenase alpha subunit, putative - Leishmania major
Length = 479
Score = 105 bits (252), Expect = 1e-21
Identities = 55/104 (52%), Positives = 70/104 (67%), Gaps = 4/104 (3%)
Frame = +3
Query: 402 MYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEG--IT*AAPRHSHRKIWSSVQYREVG 575
M M+ + MDKI+ E+QRQGRISFYMT +GEE I AA S+ ++++ QYRE G
Sbjct: 124 MMSAMLTHNTMDKIMLEAQRQGRISFYMTMFGEEAAVIGAAAGLASNDELFA--QYREAG 181
Query: 576 VFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSK--HHNMVT 701
+ YRG T+ E + QC GNCE KGRQMP+HYGSK H MV+
Sbjct: 182 ILTYRGYTIPEFIAQCMGNCECDAKGRQMPIHYGSKRLHAQMVS 225
>UniRef50_Q5QUK4 Cluster: Alpha keto acid dehydrogenase complex, E1
component, alpha subunit; n=32; Gammaproteobacteria|Rep:
Alpha keto acid dehydrogenase complex, E1 component,
alpha subunit - Idiomarina loihiensis
Length = 395
Score = 103 bits (246), Expect = 6e-21
Identities = 54/144 (37%), Positives = 83/144 (57%)
Frame = +3
Query: 273 VSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYE 452
V++ K+F++ S IP+ +++ +G + P DK ++ ++ TM + +D+ +
Sbjct: 12 VTKPKWFDKDSVT-IPMLQILKEDGSFHKDADMPEYDKELIVKIHDTMQFIRILDERMIA 70
Query: 453 SQRQGRISFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGN 632
+QRQGRISFY+ + GEE + A+ QYRE G YRG TV + +NQ + N
Sbjct: 71 AQRQGRISFYLASRGEEAESVASAAALDAGDMIMGQYREQGALAYRGFTVEQFMNQLFSN 130
Query: 633 CEDPGKGRQMPVHYGSKHHNMVTI 704
+D GKGRQMPVHYG N +TI
Sbjct: 131 EKDLGKGRQMPVHYGCADLNFMTI 154
>UniRef50_Q1KSF2 Cluster: Mitochondrial branched-chain alpha-keto
acid dehydrogenase E1; n=1; Toxoplasma gondii|Rep:
Mitochondrial branched-chain alpha-keto acid
dehydrogenase E1 - Toxoplasma gondii
Length = 463
Score = 102 bits (244), Expect = 1e-20
Identities = 56/145 (38%), Positives = 80/145 (55%)
Frame = +3
Query: 270 YVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILY 449
+ ++M NET IPI+R++D +GQI D + P + ++ Y+ MV+LS D + Y
Sbjct: 78 FTTDMNISNETPV--IPIFRILDYDGQIADGWQCP-MTNDEVLEAYQFMVKLSIWDNMFY 134
Query: 450 ESQRQGRISFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYG 629
QRQGRISFY+ N GEE + A +K QYRE+GV + G T + + Q +
Sbjct: 135 SVQRQGRISFYIQNQGEEALQTAVGLALDKKDHLFCQYRELGVLMLHGFTAEDALEQLFA 194
Query: 630 NCEDPGKGRQMPVHYGSKHHNMVTI 704
D KGRQMP+ Y N+ TI
Sbjct: 195 RRGDESKGRQMPISYSKHSVNLHTI 219
>UniRef50_Q9YBC0 Cluster: Pyruvate dehydrogenase E1 component, alpha
subunit; n=1; Aeropyrum pernix|Rep: Pyruvate
dehydrogenase E1 component, alpha subunit - Aeropyrum
pernix
Length = 377
Score = 83.0 bits (196), Expect = 7e-15
Identities = 36/124 (29%), Positives = 70/124 (56%)
Frame = +3
Query: 327 RVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEG 506
R +D G+++D+ P + + ++ +Y MV+ +D L + QR G+++ + N G+E
Sbjct: 16 RAVDEEGRVVDEELLPKVSEGEIVEIYTYMVRARVIDSWLLKLQRMGKVALHAPNKGQEA 75
Query: 507 IT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKH 686
+ A + R W YRE+G +L RGM+ E++++ N +DP KG + +G++
Sbjct: 76 VAVGAAKPLRRDDWVFPSYRELGAYLVRGMSEEEILDRALANADDPLKGSDFAI-FGNRK 134
Query: 687 HNMV 698
+N+V
Sbjct: 135 YNLV 138
>UniRef50_A7HBV0 Cluster: 3-methyl-2-oxobutanoate dehydrogenase;
n=4; Cystobacterineae|Rep: 3-methyl-2-oxobutanoate
dehydrogenase - Anaeromyxobacter sp. Fw109-5
Length = 399
Score = 81.8 bits (193), Expect = 2e-14
Identities = 41/118 (34%), Positives = 62/118 (52%)
Frame = +3
Query: 318 PIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYG 497
P+YR++ +G+++ +E L A ++ +Y+ MV +D+ + QRQGRI FY+ + G
Sbjct: 31 PLYRLVAEDGELVGAPDEVTLPDAEVLRLYRLMVLNRSLDERMITLQRQGRIGFYIGSIG 90
Query: 498 EEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVH 671
EE + W YRE G L RGM + + +GN D KGRQMP H
Sbjct: 91 EEATILGSAAAMAESDWIFPCYREHGAALMRGMPLVTFLCDLFGNAGDAMKGRQMPCH 148
>UniRef50_Q4N1L6 Cluster: Branched-chain alpha keto-acid
dehydrogenase, putative; n=3; Piroplasmida|Rep:
Branched-chain alpha keto-acid dehydrogenase, putative -
Theileria parva
Length = 464
Score = 80.6 bits (190), Expect = 4e-14
Identities = 48/145 (33%), Positives = 76/145 (52%), Gaps = 10/145 (6%)
Frame = +3
Query: 300 TSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISF 479
T + +PI++VM +G + + ++ P + + MV+L+ D + Y QRQGRISF
Sbjct: 75 TDSQVMPIFQVMKTDGTLHEGHKSPFESDEKVKEYLQIMVKLNVWDNLFYNIQRQGRISF 134
Query: 480 YMTNYGEE------GIT*AAPRH---SHRKIWSSVQ-YREVGVFLYRGMTVTELVNQCYG 629
Y+ N GEE G+ H +R + +RE+GV +G T +++ Q +
Sbjct: 135 YIQNQGEEATQLGAGLALQPQDHLFCQYRYFTKDYKNFRELGVIYVKGCTEDDVLAQLFS 194
Query: 630 NCEDPGKGRQMPVHYGSKHHNMVTI 704
+D GKGRQMP+ Y K N+ TI
Sbjct: 195 THKDEGKGRQMPISYSKKEVNLHTI 219
>UniRef50_Q6YPX5 Cluster: Thiamine pyrophosphate-dependent
dehydrogenase, E1 component alpha subunit; n=2;
Candidatus Phytoplasma asteris|Rep: Thiamine
pyrophosphate-dependent dehydrogenase, E1 component
alpha subunit - Onion yellows phytoplasma
Length = 363
Score = 79.0 bits (186), Expect = 1e-13
Identities = 39/111 (35%), Positives = 59/111 (53%), Gaps = 2/111 (1%)
Frame = +3
Query: 306 YEPIP--IYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISF 479
Y+P+ ++++D NG ++ EP L K L+ MYKTMV D + QRQGR+
Sbjct: 6 YDPLKGKQFQILDENGNLVQPELEPKLSKDVLLKMYKTMVLGRQADLAALKYQRQGRMGN 65
Query: 480 YMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGN 632
Y+ N G+E + W S YR+ G+FLYRG+++ + YGN
Sbjct: 66 YLLNSGQEASQVGVAAALEPQDWVSPYYRDAGIFLYRGVSLEQFYLYWYGN 116
>UniRef50_P35485 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=2; Firmicutes|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Acholeplasma
laidlawii
Length = 345
Score = 70.1 bits (164), Expect = 5e-11
Identities = 36/99 (36%), Positives = 51/99 (51%)
Frame = +3
Query: 336 DNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT* 515
D NG+++++ EP L K TL+ MYKT V + D + QRQGR+ Y N G+E
Sbjct: 1 DQNGKVVNEKMEPKLPKETLLKMYKTAVLGRNADIKALQYQRQGRMLTYAPNMGQEAAQI 60
Query: 516 AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGN 632
+ W+S YRE+ LYRG + + YGN
Sbjct: 61 GMAAAMEPQDWNSPMYRELNTLLYRGDKLENVFLYWYGN 99
>UniRef50_O48615 Cluster: Alpha-keto acid dehydrogenase-like
protein; n=21; Eukaryota|Rep: Alpha-keto acid
dehydrogenase-like protein - Hordeum vulgare (Barley)
Length = 64
Score = 66.5 bits (155), Expect = 6e-10
Identities = 29/48 (60%), Positives = 34/48 (70%)
Frame = +3
Query: 558 QYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVT 701
QYRE GV L+RG T+ E NQ +GN D GKGRQMP+HYGS N+ T
Sbjct: 12 QYREPGVLLWRGFTLQEFANQLFGNNLDYGKGRQMPIHYGSNRLNLFT 59
>UniRef50_Q97CK0 Cluster: 2-oxoisovalerate dehydrogenase alpha
subunit; n=2; Thermoplasma|Rep: 2-oxoisovalerate
dehydrogenase alpha subunit - Thermoplasma volcanium
Length = 337
Score = 66.1 bits (154), Expect = 9e-10
Identities = 34/107 (31%), Positives = 55/107 (51%)
Frame = +3
Query: 384 KATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRHSHRKIWSSVQY 563
K+ + + +MV DK + +QRQG + FY G+E A ++ Y
Sbjct: 10 KSLYVKGFTSMVLGRLFDKKVITAQRQGLVGFYTPMMGQEATQAGAAMALSKQDLVYGYY 69
Query: 564 REVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTI 704
R+V + +Y G + ++ +Q GN ED KGRQMP HY +K N +++
Sbjct: 70 RDVTLLIYLGYPIEKIFDQIMGNAEDTSKGRQMPSHYSAKAVNFMSV 116
>UniRef50_Q9RPS5 Cluster: TPP-dependent branched-chain alpha-keto
acid dehydrogenase, E1 alpha subunit; n=3;
Lactobacillales|Rep: TPP-dependent branched-chain
alpha-keto acid dehydrogenase, E1 alpha subunit -
Enterococcus faecalis (Streptococcus faecalis)
Length = 330
Score = 62.9 bits (146), Expect = 8e-09
Identities = 38/114 (33%), Positives = 62/114 (54%), Gaps = 2/114 (1%)
Frame = +3
Query: 366 EEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*A-APRHSHRK 542
++ L K LI Y+ +++ +D+ L++ R G+ SF ++ G E A A + +K
Sbjct: 7 KKSGLSKEELIQAYRQVLRGRRLDERLWQLTRIGKTSFNISGQGAEVAQVAMAMAFNPQK 66
Query: 543 IWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGK-GRQMPVHYGSKHHNMVT 701
+ YR++ L GMT +++ +G DP GRQMP HYGSK HN+V+
Sbjct: 67 DYFLPYYRDMTACLVWGMTSKDILMGSFGKEADPSSHGRQMPNHYGSKEHNIVS 120
>UniRef50_Q9HN77 Cluster: Pyruvate dehydrogenase alpha subunit; n=8;
Halobacteriaceae|Rep: Pyruvate dehydrogenase alpha
subunit - Halobacterium salinarium (Halobacterium
halobium)
Length = 419
Score = 62.9 bits (146), Expect = 8e-09
Identities = 35/99 (35%), Positives = 48/99 (48%)
Frame = +3
Query: 312 PIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTN 491
P YRV+D NG+++D E P+L L+ MY+ M D+ QRQGRI Y
Sbjct: 57 PDDTYRVLDENGELVDGAEVPDLTDDELVEMYRYMKLARRFDERAVSLQRQGRIGTYPPL 116
Query: 492 YGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTE 608
G+EG A+ W YRE G L RG+ + +
Sbjct: 117 SGQEGAQIASAMALADDDWIVPSYREHGASLVRGLPLKD 155
>UniRef50_P09060 Cluster: 2-oxoisovalerate dehydrogenase subunit
alpha; n=68; Proteobacteria|Rep: 2-oxoisovalerate
dehydrogenase subunit alpha - Pseudomonas putida
Length = 410
Score = 61.3 bits (142), Expect = 2e-08
Identities = 37/128 (28%), Positives = 61/128 (47%)
Frame = +3
Query: 321 IYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGE 500
+ RV+D G E ++D L + M++ D + +QRQ ++SFYM + GE
Sbjct: 54 LVRVLDEQGDAQGPWAE-DIDPQILRQGMRAMLKTRIFDSRMVVAQRQKKMSFYMQSLGE 112
Query: 501 EGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGS 680
E I +R YR+ + + R +++ E++ Q N DP KGRQ+P+ Y
Sbjct: 113 EAIGSGQALALNRTDMCFPTYRQQSILMARDVSLVEMICQLLSNERDPLKGRQLPIMYSV 172
Query: 681 KHHNMVTI 704
+ TI
Sbjct: 173 REAGFFTI 180
>UniRef50_P37940 Cluster: 2-oxoisovalerate dehydrogenase subunit
alpha; n=37; Firmicutes|Rep: 2-oxoisovalerate
dehydrogenase subunit alpha - Bacillus subtilis
Length = 330
Score = 61.3 bits (142), Expect = 2e-08
Identities = 35/117 (29%), Positives = 62/117 (52%), Gaps = 2/117 (1%)
Frame = +3
Query: 357 DKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRHSH 536
++++ L ++MY+TM+ +D+ ++ R G+I F ++ G+E A
Sbjct: 4 NRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPFVISCQGQEAAQVGAAFALD 63
Query: 537 RKI-WSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGK-GRQMPVHYGSKHHNMVT 701
R++ + YR++GV L GMT +L+ + DP GRQMP H+G K + +VT
Sbjct: 64 REMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNSGGRQMPGHFGQKKNRIVT 120
>UniRef50_Q9RYC1 Cluster: 2-oxo acid dehydrogenase, E1 component,
alpha subunit; n=2; Deinococcus|Rep: 2-oxo acid
dehydrogenase, E1 component, alpha subunit - Deinococcus
radiodurans
Length = 381
Score = 60.1 bits (139), Expect = 6e-08
Identities = 37/108 (34%), Positives = 56/108 (51%), Gaps = 3/108 (2%)
Frame = +3
Query: 387 ATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*A---APRHSHRKIWSSV 557
A L +++ M+Q D+ L RQGR SFY G E A R H +W
Sbjct: 43 ALLRELHRLMLQGREFDRKLITLLRQGRTSFYSQASGMEATQIGLAKAIRAGHDWVWGYY 102
Query: 558 QYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVT 701
+ + +G+ L G+ + L++QC G+ D +GRQMP H+ S+ HN V+
Sbjct: 103 RDQVLGMGL--GVPMFTLISQCLGSNTDECRGRQMPHHFSSRAHNFVS 148
>UniRef50_A0M1U4 Cluster: 2-oxoisovalerate dehydrogenase E1
component subunits alpha and beta; n=18;
Bacteroidetes|Rep: 2-oxoisovalerate dehydrogenase E1
component subunits alpha and beta - Gramella forsetii
(strain KT0803)
Length = 685
Score = 58.8 bits (136), Expect = 1e-07
Identities = 37/150 (24%), Positives = 74/150 (49%), Gaps = 1/150 (0%)
Frame = +3
Query: 288 FFNETSYEPIPIYRVMDNNGQIIDKN-EEPNLDKATLINMYKTMVQLSHMDKILYESQRQ 464
FF+ + Y ++ NN + +E L ++++Y++M++ +++ + RQ
Sbjct: 4 FFSLECFTDKQNYFMLSNNTKSRTMEYKETQLSNDAMLDLYRSMLKPRMIEEKMLILLRQ 63
Query: 465 GRISFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDP 644
G+IS + + G+E I+ + + + +R +GVF R + + L Q G
Sbjct: 64 GKISKWFSGIGQEAISVGVTKSLETEEYILPMHRNLGVFTSREIPLNRLFAQWQGKASGF 123
Query: 645 GKGRQMPVHYGSKHHNMVTII*FH*GTQIG 734
KGR H+G++ +N+V +I H G Q+G
Sbjct: 124 TKGRDRSFHFGTQEYNIVGMI-SHLGPQLG 152
>UniRef50_Q67ME6 Cluster: Branched-chain alpha-keto acid
dehydrogenase E1 alpha subunit; n=23; Bacteria|Rep:
Branched-chain alpha-keto acid dehydrogenase E1 alpha
subunit - Symbiobacterium thermophilum
Length = 352
Score = 58.0 bits (134), Expect = 2e-07
Identities = 36/116 (31%), Positives = 61/116 (52%), Gaps = 2/116 (1%)
Frame = +3
Query: 360 KNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGI-T*AAPRHSH 536
++E L + MY M+ +D+ L+ QR G+I F ++ G+E AA
Sbjct: 26 RHEALGLTADQVREMYYYMLLTRRLDERLWLLQRGGKIPFVISPQGQEAAQVGAAFAFRR 85
Query: 537 RKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGK-GRQMPVHYGSKHHNMVT 701
R+ W + YR++GV L G+T E++ + DP G+QMP H+G++ N+V+
Sbjct: 86 RQDWFTPYYRDLGVNLVVGVTPREVMLSAFARGADPASGGKQMPSHWGNRPLNIVS 141
>UniRef50_Q4L1A7 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=9; Mycoplasma|Rep: Pyruvate dehydrogenase E1
component alpha subunit - Mycoplasma synoviae
Length = 374
Score = 57.2 bits (132), Expect = 4e-07
Identities = 35/109 (32%), Positives = 51/109 (46%), Gaps = 1/109 (0%)
Frame = +3
Query: 309 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 488
+P + RV+D NG +IDK +P L L+ YK MV D + + QRQGR+ +
Sbjct: 20 DPSKLIRVLDVNGNLIDKKYKPQLTDKQLVEGYKWMVLSRQQDTYMLQLQRQGRMLTFAP 79
Query: 489 NYGEEGIT*A-APRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGN 632
N GEE + A A +K W +R L G+ + + GN
Sbjct: 80 NLGEEALQVATAFALDKKKDWFLPAFRSNATMLALGVPMVNQMLYWNGN 128
>UniRef50_Q5KUY4 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
alpha subunit; n=2; Geobacillus|Rep: Pyruvate
dehydrogenase E1 (Lipoamide) alpha subunit - Geobacillus
kaustophilus
Length = 359
Score = 54.4 bits (125), Expect = 3e-06
Identities = 35/118 (29%), Positives = 53/118 (44%)
Frame = +3
Query: 312 PIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTN 491
P+ I R++D NG D+ + L+ Y+ M + +D+ L QRQGRI Y
Sbjct: 8 PVEIVRILDENGNG-DEEKLAAFSDEWLLRAYREMRRARVIDERLLRMQRQGRIGTYAPF 66
Query: 492 YGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMP 665
G+E + H+ W YREV V L GM + + + G G++MP
Sbjct: 67 SGQEAAQIGSALALHKDDWIFPSYREVAVCLMHGMPLEQFFHYVQGRL----SGKRMP 120
>UniRef50_P47516 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=5; Mycoplasma|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Mycoplasma
genitalium
Length = 358
Score = 54.4 bits (125), Expect = 3e-06
Identities = 36/121 (29%), Positives = 54/121 (44%)
Frame = +3
Query: 312 PIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTN 491
P +Y+V DN G++ID N + L L + Y M MDK + QR G++ + N
Sbjct: 10 PTTLYQVYDNEGKLIDPNHKITLTDEQLKHAYYLMNLSRMMDKKMLVWQRAGKMLNFAPN 69
Query: 492 YGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVH 671
GEE + + W +R + LYRG+ +L+ GN KG Q+
Sbjct: 70 LGEEALQVGMGLGLNENDWVCPTFRSGALMLYRGVKPEQLLLYWNGN----EKGSQIDAK 125
Query: 672 Y 674
Y
Sbjct: 126 Y 126
>UniRef50_Q72GU1 Cluster: 2-oxoisovalerate dehydrogenase subunit
alpha; n=2; Thermus thermophilus|Rep: 2-oxoisovalerate
dehydrogenase subunit alpha - Thermus thermophilus
(strain HB27 / ATCC BAA-163 / DSM 7039)
Length = 367
Score = 53.6 bits (123), Expect = 5e-06
Identities = 45/146 (30%), Positives = 65/146 (44%), Gaps = 2/146 (1%)
Frame = +3
Query: 273 VSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYE 452
V E F + EPI R++ G+ + + +L+ L +Y+ M+ +D+
Sbjct: 2 VKETHRFEPFTEEPI---RLIGEEGEWLG-DFPLDLEGEKLRRLYRDMLAARMLDERYTI 57
Query: 453 SQRQGRISFYMTNYGEEGIT*AAPRHSHRK--IWSSVQYREVGVFLYRGMTVTELVNQCY 626
R G+ SF G E A H+ R W YR+ G+ L G+ + EL Q
Sbjct: 58 LIRTGKTSFIAPAAGHEAAQ-VAIAHAIRPGFDWVFPYYRDHGLALALGIPLKELFGQML 116
Query: 627 GNCEDPGKGRQMPVHYGSKHHNMVTI 704
DP KGRQMP H GSK N T+
Sbjct: 117 ATKADPNKGRQMPEHPGSKALNFFTV 142
>UniRef50_Q020J5 Cluster: Dehydrogenase, E1 component; n=1;
Solibacter usitatus Ellin6076|Rep: Dehydrogenase, E1
component - Solibacter usitatus (strain Ellin6076)
Length = 697
Score = 53.2 bits (122), Expect = 6e-06
Identities = 33/105 (31%), Positives = 51/105 (48%), Gaps = 2/105 (1%)
Frame = +3
Query: 393 LINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRHSHR-KIWSSVQYRE 569
LI ++ M +D +RQ RI F ++ G E + AA + W YR+
Sbjct: 22 LIRAFRIMHTARRLDDREIALKRQNRIFFQISGAGHEAVQVAAAMSLRPGRDWVYPYYRD 81
Query: 570 VGVFLYRGMTVTELVNQCYGNCEDPGK-GRQMPVHYGSKHHNMVT 701
+ L G+T E++ Q G DP GRQMP H+G+ +N+V+
Sbjct: 82 RALCLALGVTPLEMLQQAVGAAADPASGGRQMPSHWGNAAYNIVS 126
>UniRef50_Q8CX87 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
alpha subunit; n=5; Bacillaceae|Rep: Pyruvate
dehydrogenase E1 (Lipoamide) alpha subunit -
Oceanobacillus iheyensis
Length = 358
Score = 52.4 bits (120), Expect = 1e-05
Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 3/117 (2%)
Frame = +3
Query: 309 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 488
E P+ R+MD NG+I D + +DKA + Y+ ++ + D+ QRQGRI Y
Sbjct: 7 EEFPMIRIMDQNGKITDTSYLEQIDKALVQQFYRQLICMRAFDQKAINLQRQGRIGTYPG 66
Query: 489 NYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVN---QCYGNCEDPGK 650
G+EG + W YR+ + G + T L + + GN GK
Sbjct: 67 FEGQEGAQVGSALALDEDDWMLPTYRDHAASITFGKSYTILSSWNGRVEGNLPPEGK 123
>UniRef50_Q8EVQ2 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=1; Mycoplasma penetrans|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Mycoplasma
penetrans
Length = 359
Score = 50.4 bits (115), Expect = 5e-05
Identities = 28/103 (27%), Positives = 49/103 (47%)
Frame = +3
Query: 324 YRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 503
Y V+D +G + L + Y TMV MD+ + + QRQG++ + N GEE
Sbjct: 13 YSVLDIDGNVTQVGYRIPLSNEEIEKAYYTMVLTRRMDEKMIKWQRQGKMLTFPPNMGEE 72
Query: 504 GIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGN 632
+ A ++ W + +R VFL+ G+ + +++ GN
Sbjct: 73 ALQVATSISMDKQDWFAPAFRSAAVFLHSGVPMWKIMLVWKGN 115
>UniRef50_Q7N5R1 Cluster: Similar to 3-methyl-2-oxobutanoate
dehydrogenase; n=1; Photorhabdus luminescens subsp.
laumondii|Rep: Similar to 3-methyl-2-oxobutanoate
dehydrogenase - Photorhabdus luminescens subsp.
laumondii
Length = 665
Score = 50.4 bits (115), Expect = 5e-05
Identities = 29/93 (31%), Positives = 46/93 (49%)
Frame = +3
Query: 459 RQGRISFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCE 638
RQGR F+++ G EG+ P+ + YR+ + L RGM++ E+ + G
Sbjct: 46 RQGRAWFHVSAAGHEGLA-VLPQLMEKNDVLVPYYRDRALVLARGMSIVEMTRELMGKAT 104
Query: 639 DPGKGRQMPVHYGSKHHNMVTII*FH*GTQIGP 737
GR M H+ SK HN+ +++ GTQ P
Sbjct: 105 SHSAGRTMSNHFCSKEHNIFSVVSLT-GTQCIP 136
>UniRef50_A1UJ85 Cluster: Pyruvate dehydrogenase; n=16;
Mycobacterium|Rep: Pyruvate dehydrogenase -
Mycobacterium sp. (strain KMS)
Length = 356
Score = 49.6 bits (113), Expect = 8e-05
Identities = 26/79 (32%), Positives = 39/79 (49%)
Frame = +3
Query: 375 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRHSHRKIWSS 554
+L TL +Y+TMV +D QRQG ++ Y + G+E A + W
Sbjct: 27 DLPPETLAWLYETMVVTRDLDTEFVHLQRQGELALYASCRGQEAAQIGATACLRKTDWLF 86
Query: 555 VQYREVGVFLYRGMTVTEL 611
QYRE+G FL RG+ ++
Sbjct: 87 PQYREIGAFLLRGIAPAQM 105
>UniRef50_Q1IQR3 Cluster: Dehydrogenase, E1 component; n=1;
Acidobacteria bacterium Ellin345|Rep: Dehydrogenase, E1
component - Acidobacteria bacterium (strain Ellin345)
Length = 736
Score = 49.2 bits (112), Expect = 1e-04
Identities = 37/118 (31%), Positives = 54/118 (45%), Gaps = 2/118 (1%)
Frame = +3
Query: 354 IDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRHS 533
++K E L + L+ Y+ M +D +RQ R+ F ++ G E + AA
Sbjct: 18 VNKTYE-GLTREDLLRAYRLMYLSRRIDDREILLKRQQRVFFQISGAGHEAMLVAAGLLL 76
Query: 534 HRKI-WSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGKG-RQMPVHYGSKHHNMVT 701
W YR+ + L GMT E++ G DP G RQMP H+G K N+VT
Sbjct: 77 KPGYDWFFPYYRDRALCLALGMTAEEMLLGAVGAAADPNSGGRQMPSHWGHKGLNIVT 134
>UniRef50_A6GB57 Cluster: Pyruvate dehydrogenase; n=1; Plesiocystis
pacifica SIR-1|Rep: Pyruvate dehydrogenase -
Plesiocystis pacifica SIR-1
Length = 308
Score = 48.4 bits (110), Expect = 2e-04
Identities = 34/133 (25%), Positives = 60/133 (45%)
Frame = +3
Query: 300 TSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISF 479
T++EP + ++D+ G + D LD L + YK +V +D L + +
Sbjct: 4 TAWEPEGVEALLDSKGALADPAAVSGLD---LRSFYKQLVAARILDLKLGRLE----LPM 56
Query: 480 YMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQ 659
+ GEE ++ A + W V R+ V L RG+ +TE++ Q G +GR
Sbjct: 57 WAPAAGEEAVSVAVGSLVGEEDWVFVGNRDAAVALTRGLPLTEILRQLLGQASAETRGRG 116
Query: 660 MPVHYGSKHHNMV 698
+P S+ H ++
Sbjct: 117 LPGSLSSREHKLM 129
>UniRef50_A6CP23 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
alpha subunit; n=2; Bacillus sp. SG-1|Rep: Pyruvate
dehydrogenase E1 (Lipoamide) alpha subunit - Bacillus
sp. SG-1
Length = 364
Score = 48.4 bits (110), Expect = 2e-04
Identities = 28/106 (26%), Positives = 49/106 (46%)
Frame = +3
Query: 297 ETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRIS 476
E E PI R++DN+G ++ +++P + + Y+ MV++ DK QRQGRI
Sbjct: 9 EEMEEQFPIKRIIDNDGTLLG-DKDPGITEQLAKEFYRHMVRIRTFDKKAISLQRQGRIG 67
Query: 477 FYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELV 614
Y G+E + W YR+ G + G ++ ++
Sbjct: 68 TYAPFEGQEASQVGSSAALKEDDWMFPSYRDHGAAMTFGHSLRNIL 113
>UniRef50_Q0W151 Cluster: Pyruvate dehydrogenase complex E1,
transketolase alpha subunit; n=1; uncultured
methanogenic archaeon RC-I|Rep: Pyruvate dehydrogenase
complex E1, transketolase alpha subunit - Uncultured
methanogenic archaeon RC-I
Length = 359
Score = 48.4 bits (110), Expect = 2e-04
Identities = 34/120 (28%), Positives = 56/120 (46%), Gaps = 5/120 (4%)
Frame = +3
Query: 324 YRVMDNNGQIIDKNE-EPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGE 500
+R++ +G NE +P L + L+ MY+ MVQ D+ + QR GR+ Y G+
Sbjct: 15 FRIVSQDGSA---NELDPGLPEDLLLKMYRLMVQARTYDEKALKLQRGGRMGTYPPIAGQ 71
Query: 501 EGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTEL----VNQCYGNCEDPGKGRQMPV 668
E I + + W YRE+G + +G+ + L + YGN P R +P+
Sbjct: 72 EAIQIGSALAMAEEDWMVPSYREIGAMIAKGVPMQTLYMLWMGNDYGN-RTPDNVRCLPI 130
>UniRef50_Q6L1L8 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=2; Thermoplasmatales|Rep: Pyruvate
dehydrogenase E1 component alpha subunit - Picrophilus
torridus
Length = 333
Score = 46.0 bits (104), Expect = 0.001
Identities = 31/113 (27%), Positives = 53/113 (46%)
Frame = +3
Query: 369 EPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRHSHRKIW 548
E ++ K +I+ Y+ MV +DK L RQG + FY+ N G E + A +
Sbjct: 3 EEDISKEDIISAYRNMVLERFLDKKLLGINRQGFLPFYIPNIGHEALHAAIGMAIRDDDF 62
Query: 549 SSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTII 707
YR++G + R + + ++ Q + D GR MP+H +K + +I
Sbjct: 63 FYPYYRDLGSDIAR-VGLDFVLAQMFSTEMDNELGRDMPLHISNKAKRVGPVI 114
>UniRef50_Q835M4 Cluster: Pyruvate dehydrogenase complex E1
component, alpha subunit; n=10; Bacilli|Rep: Pyruvate
dehydrogenase complex E1 component, alpha subunit -
Enterococcus faecalis (Streptococcus faecalis)
Length = 371
Score = 44.8 bits (101), Expect = 0.002
Identities = 23/97 (23%), Positives = 49/97 (50%)
Frame = +3
Query: 318 PIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYG 497
P ++++D +G+I++++ P+L L+ + MV +D+ RQGR+ F+ G
Sbjct: 24 PTFQILDQDGKIVNEDLVPDLSDEELVELMTRMVWSRVLDQRSTALNRQGRLGFFAPTAG 83
Query: 498 EEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTE 608
+E A+ ++ + YR+V + G+ + E
Sbjct: 84 QEASQLASQFAMEKEDYLLPGYRDVPQLVQHGLPLRE 120
>UniRef50_P21873 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=33; Bacilli|Rep: Pyruvate dehydrogenase
E1 component subunit alpha - Bacillus stearothermophilus
(Geobacillus stearothermophilus)
Length = 369
Score = 44.8 bits (101), Expect = 0.002
Identities = 22/96 (22%), Positives = 46/96 (47%)
Frame = +3
Query: 309 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 488
E P +++++ G+++++ P L L + + MV +D+ RQGR+ FY
Sbjct: 19 EQFPTFQILNEEGEVVNEEAMPELSDEQLKELMRRMVYTRILDQRSISLNRQGRLGFYAP 78
Query: 489 NYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGM 596
G+E A+ ++ + YR+V ++ G+
Sbjct: 79 TAGQEASQIASHFALEKEDFILPGYRDVPQIIWHGL 114
>UniRef50_Q7NLM8 Cluster: Gll1094 protein; n=1; Gloeobacter
violaceus|Rep: Gll1094 protein - Gloeobacter violaceus
Length = 481
Score = 44.0 bits (99), Expect = 0.004
Identities = 24/79 (30%), Positives = 38/79 (48%)
Frame = +3
Query: 459 RQGRISFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCE 638
RQG+ ++ G E + A H HR+ + YR+ + L +G T +L + +
Sbjct: 34 RQGKGWIHIPGMGHESLI-AITHHLHREDYLFTYYRDRALMLGKGFTAQQLAWDYFACAK 92
Query: 639 DPGKGRQMPVHYGSKHHNM 695
GR MPVH +KH N+
Sbjct: 93 SSTGGRGMPVHCSAKHLNI 111
>UniRef50_Q6MAE2 Cluster: Putative pyruvate dehydrogenase
(Lipoamide), E1 component, alpha chain; n=1; Candidatus
Protochlamydia amoebophila UWE25|Rep: Putative pyruvate
dehydrogenase (Lipoamide), E1 component, alpha chain -
Protochlamydia amoebophila (strain UWE25)
Length = 342
Score = 44.0 bits (99), Expect = 0.004
Identities = 27/100 (27%), Positives = 47/100 (47%), Gaps = 1/100 (1%)
Frame = +3
Query: 378 LDKATLINMYKTMVQLSHMDKILYESQRQGRIS-FYMTNYGEEGIT*AAPRHSHRKIWSS 554
L LI ++ M+++ + + + +QG+I F+ G+E I AA + + W +
Sbjct: 21 LGPQALIECFQQMLKIRNFELRAESAYQQGKIGGFFHAYVGQEAIQTAAVQAIGQSNWYA 80
Query: 555 VQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHY 674
YR + L G T EL+ + YG KGR +H+
Sbjct: 81 TSYRCHALALLLGATPNELMAELYGRATGNAKGRGGSMHF 120
>UniRef50_A0LLM4 Cluster: Pyruvate dehydrogenase; n=1;
Syntrophobacter fumaroxidans MPOB|Rep: Pyruvate
dehydrogenase - Syntrophobacter fumaroxidans (strain DSM
10017 / MPOB)
Length = 365
Score = 43.6 bits (98), Expect = 0.005
Identities = 29/107 (27%), Positives = 53/107 (49%)
Frame = +3
Query: 330 VMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGI 509
+++ NG++ DK+ EP++ ++ L+ +Y+ MV D+ + QRQGRI + G+E
Sbjct: 17 ILNENGEV-DKSLEPDIPESLLVKLYRAMVLSRKFDERMLILQRQGRIGTFAPIKGQEAQ 75
Query: 510 T*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGK 650
A W +RE+ ++RG + E V Y + G+
Sbjct: 76 V-GAVALLEPGDWLVPSFREMPAEVWRGKKL-ENVLLLYAGYNEGGR 120
>UniRef50_A5IXN2 Cluster: Pyruvate dehydrogenase E1 component,
alphasubunit; n=1; Mycoplasma agalactiae|Rep: Pyruvate
dehydrogenase E1 component, alphasubunit - Mycoplasma
agalactiae
Length = 363
Score = 43.2 bits (97), Expect = 0.007
Identities = 25/108 (23%), Positives = 50/108 (46%)
Frame = +3
Query: 309 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 488
+P R +D +G++I + + K L+ MYK M++ D Q+ GR+ +
Sbjct: 14 DPNETVRFLDVDGKLIQEFKPSAETKKKLVEMYKNMIRSRQWDLYSLTLQKTGRLGTFAP 73
Query: 489 NYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGN 632
GEE + +++ W YR + L RG+++ ++ + G+
Sbjct: 74 ALGEEAALTGIGFNLNKEDWFIPHYRVLPTQLARGISMDKIYSYWQGS 121
>UniRef50_A5UU15 Cluster: Pyruvate dehydrogenase; n=3; Chloroflexi
(class)|Rep: Pyruvate dehydrogenase - Roseiflexus sp.
RS-1
Length = 350
Score = 40.3 bits (90), Expect = 0.049
Identities = 27/111 (24%), Positives = 47/111 (42%), Gaps = 1/111 (0%)
Frame = +3
Query: 363 NEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIT*AAPRHSHR 539
+ + LD ATLI+ Y+ MV + ++ E + +I ++ Y GEE A
Sbjct: 16 SNDSGLDAATLIDYYRQMVLIRRFEEKCQEMYTRAKIGGFLHLYIGEEATAVGAIAALRP 75
Query: 540 KIWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHN 692
YR+ G + RG+ + L+ + +G KG +H+ N
Sbjct: 76 DDHIFTHYRDHGHAIARGLDINALMAELFGKVTGCSKGLGGSMHFADASKN 126
>UniRef50_A7D3P2 Cluster: Pyruvate dehydrogenase; n=1; Halorubrum
lacusprofundi ATCC 49239|Rep: Pyruvate dehydrogenase -
Halorubrum lacusprofundi ATCC 49239
Length = 382
Score = 40.3 bits (90), Expect = 0.049
Identities = 33/125 (26%), Positives = 52/125 (41%), Gaps = 3/125 (2%)
Frame = +3
Query: 324 YRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 503
YRV+ +G + P+L +Y+ +V D+ QRQGRI Y G+E
Sbjct: 22 YRVLGPDGIPLPDATVPDLSDERFRAIYRDLVTTRRFDERAVSLQRQGRIGTYAPCAGQE 81
Query: 504 GIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGN---CEDPGKGRQMPVHY 674
G + + S QYRE G + R + ++E + G+ E G P++
Sbjct: 82 GSAVGSTHALADRDLISYQYREHGAIVVRDL-LSEYLPYWLGHESGTEAIADGNVFPLNI 140
Query: 675 GSKHH 689
G H
Sbjct: 141 GIAAH 145
>UniRef50_A0K283 Cluster: Pyruvate dehydrogenase; n=4;
Actinobacteria (class)|Rep: Pyruvate dehydrogenase -
Arthrobacter sp. (strain FB24)
Length = 415
Score = 39.9 bits (89), Expect = 0.064
Identities = 25/84 (29%), Positives = 39/84 (46%)
Frame = +3
Query: 378 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRHSHRKIWSSV 557
LD L Y M + D+ QRQG+++ ++ G+E + R S + +
Sbjct: 58 LDAEKLRGFYADMAAIRRFDQEATALQRQGQLALWVPLTGQEAAQIGSGRASQPQDYIFP 117
Query: 558 QYREVGVFLYRGMTVTELVNQCYG 629
YRE GV L R + + EL+ Q G
Sbjct: 118 TYREHGVALTRNVDLAELLRQFRG 141
>UniRef50_Q49108 Cluster: Pyruvate dehydrogenase EI alpha subunit;
n=5; Mollicutes|Rep: Pyruvate dehydrogenase EI alpha
subunit - Mycoplasma capricolum
Length = 370
Score = 39.1 bits (87), Expect = 0.11
Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 1/108 (0%)
Frame = +3
Query: 330 VMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGI 509
V+D +G++I+ P + ++ YK M D QRQGR+ ++++ G+E
Sbjct: 17 VLDKDGKVINPKLMPKISDQEILEAYKIMNLSRRQDIYQNTMQRQGRLLSFLSSTGQEAC 76
Query: 510 T*AAPRHSHRKIWSSVQ-YREVGVFLYRGMTVTELVNQCYGNCEDPGK 650
A ++K V YR +L G V ++ GN E GK
Sbjct: 77 EVAYINALNKKTDHFVSGYRNNAAWLAMGQLVRNIMLYWIGN-EAGGK 123
>UniRef50_Q8ZUR8 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=3; Pyrobaculum|Rep: Pyruvate dehydrogenase E1 alpha
subunit - Pyrobaculum aerophilum
Length = 372
Score = 39.1 bits (87), Expect = 0.11
Identities = 27/129 (20%), Positives = 55/129 (42%), Gaps = 2/129 (1%)
Frame = +3
Query: 297 ETSYEPIPIYRVMDNNGQIIDKNEEP-NLDKATLINMYKTMVQLSHMDKILYESQRQGRI 473
+T + ++RV+ +G ++ E + L Y+ MV +D+ R G++
Sbjct: 13 KTEVKEPQVFRVLGQDGSPLETYEVGYKPSEGELAKAYRWMVLGRVLDRYALMYHRMGKV 72
Query: 474 -SFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGK 650
S Y + G E + W + YR + + + RG+ + + + + DP K
Sbjct: 73 KSTYGPHEGHEAADAGTALALRPEDWVAPYYRNLTLLIARGVPLEVIWAKFFAKLGDPDK 132
Query: 651 GRQMPVHYG 677
GR + + +G
Sbjct: 133 GRNLTIEWG 141
>UniRef50_Q9KG99 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
alpha subunit; n=1; Bacillus halodurans|Rep: Pyruvate
dehydrogenase E1 (Lipoamide) alpha subunit - Bacillus
halodurans
Length = 367
Score = 38.3 bits (85), Expect = 0.20
Identities = 20/61 (32%), Positives = 34/61 (55%)
Frame = +3
Query: 321 IYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGE 500
+++V+ G+ + E LDK +++MYK M+ D+ + QRQGRI Y + G+
Sbjct: 18 LFQVLTPKGECQYEGSE-FLDKTFVLSMYKQMINCREFDEKALKLQRQGRIGTYASFKGQ 76
Query: 501 E 503
E
Sbjct: 77 E 77
>UniRef50_Q5SJR9 Cluster: Pyruvate dehydrogenase (Lipoamide) (EC
1.2.4.1) E1-alpha chain; n=2; Thermus thermophilus|Rep:
Pyruvate dehydrogenase (Lipoamide) (EC 1.2.4.1) E1-alpha
chain - Thermus thermophilus (strain HB8 / ATCC 27634 /
DSM 579)
Length = 346
Score = 38.3 bits (85), Expect = 0.20
Identities = 22/87 (25%), Positives = 38/87 (43%)
Frame = +3
Query: 354 IDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRHS 533
+D+ E P ++ L +Y+ M + D+ QRQGR+ Y G+E
Sbjct: 9 LDEGEFPLAEEEAL-RLYRAMRRARFFDEKALTLQRQGRLGVYAPFMGQEAAQVGVALAL 67
Query: 534 HRKIWSSVQYREVGVFLYRGMTVTELV 614
+ W YRE + L +G+ + L+
Sbjct: 68 EERDWVVPSYRESAMLLAKGLPIHTLI 94
>UniRef50_Q1LFS5 Cluster: Dehydrogenase, E1 component; n=22;
Proteobacteria|Rep: Dehydrogenase, E1 component -
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM
2839)
Length = 367
Score = 37.9 bits (84), Expect = 0.26
Identities = 27/89 (30%), Positives = 39/89 (43%), Gaps = 5/89 (5%)
Frame = +3
Query: 357 DKNEEPNL-----DKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AA 521
D + EP+L D ATL+ +Y+ MV D QR G+I + + G+E I
Sbjct: 18 DGSPEPDLPDFARDPATLLPLYRAMVLTRQFDLKAIAMQRTGQIGTFASALGQEAIGVGV 77
Query: 522 PRHSHRKIWSSVQYREVGVFLYRGMTVTE 608
R YR+ RG+T+TE
Sbjct: 78 ATAMRRDDVLVPSYRDHAAQFVRGVTMTE 106
>UniRef50_A5UVY9 Cluster: Pyruvate dehydrogenase; n=2;
Roseiflexus|Rep: Pyruvate dehydrogenase - Roseiflexus
sp. RS-1
Length = 334
Score = 37.9 bits (84), Expect = 0.26
Identities = 31/112 (27%), Positives = 50/112 (44%), Gaps = 4/112 (3%)
Frame = +3
Query: 378 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*A---APRHSHRKIW 548
L + LI +TM+ D L+ RQGR F +T G E A R H +
Sbjct: 15 LSRQRLIAGLRTMIASRETDDRLWLLNRQGRAHFVVTPAGHEATQLGCAWAIRVGHDYV- 73
Query: 549 SSVQYREVGVFLYRGMTVTELVNQCYGNCEDPGK-GRQMPVHYGSKHHNMVT 701
YR++ + + G +V +++ +DP GRQM H+ S+ +V+
Sbjct: 74 -VPYYRDMTLVMALGQSVLDILLHAMARRDDPSSGGRQMFGHFSSRRLRIVS 124
>UniRef50_UPI00005103B4 Cluster: COG1071: Pyruvate/2-oxoglutarate
dehydrogenase complex, dehydrogenase (E1) component,
eukaryotic type, alpha subunit; n=1; Brevibacterium
linens BL2|Rep: COG1071: Pyruvate/2-oxoglutarate
dehydrogenase complex, dehydrogenase (E1) component,
eukaryotic type, alpha subunit - Brevibacterium linens
BL2
Length = 368
Score = 36.7 bits (81), Expect = 0.60
Identities = 21/76 (27%), Positives = 34/76 (44%)
Frame = +3
Query: 387 ATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRHSHRKIWSSVQYR 566
A L +Y+ MV + + + RQGR++ Y + G+E A W YR
Sbjct: 41 AALTGLYRQMVLVRRFEAQVTHLTRQGRLATYPSAAGQEAAEVGATTALAPNDWLFPTYR 100
Query: 567 EVGVFLYRGMTVTELV 614
+ L RG+ V E++
Sbjct: 101 DSAALLTRGVPVAEIL 116
>UniRef50_Q4MTG0 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=38; Bacilli|Rep: Pyruvate dehydrogenase
E1 component subunit alpha - Bacillus cereus
Length = 371
Score = 36.7 bits (81), Expect = 0.60
Identities = 20/90 (22%), Positives = 42/90 (46%)
Frame = +3
Query: 327 RVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEG 506
++++ G+++++ P L L + + MV +D+ RQGR+ FY G+E
Sbjct: 27 QILNEKGEVVNEAAMPELSDDQLKELMRRMVYTRVLDQRSISLNRQGRLGFYAPTAGQEA 86
Query: 507 IT*AAPRHSHRKIWSSVQYREVGVFLYRGM 596
A+ + + YR+V ++ G+
Sbjct: 87 SQLASHFALEAEDFILPGYRDVPQLVWHGL 116
>UniRef50_Q5VGY4 Cluster: Pyruvate dehydrogenase alpha subunit; n=6;
Plasmodium|Rep: Pyruvate dehydrogenase alpha subunit -
Plasmodium falciparum
Length = 608
Score = 35.5 bits (78), Expect = 1.4
Identities = 28/134 (20%), Positives = 63/134 (47%), Gaps = 2/134 (1%)
Frame = +3
Query: 303 SYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFY 482
+Y IY M+NN I + + N+ + + +Y+ M + ++ + R++ +
Sbjct: 166 NYSEFNIY--MENNN-IEEYISDVNISREEICTLYEDMYLGRLFENLVAKLYYNKRVNGF 222
Query: 483 MTNY-GEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGN-CEDPGKGR 656
+ Y G+E ++ ++ + + YR+ L +G+ +++N+ YGN KG+
Sbjct: 223 VHLYNGQEAVSTGIIKNLKNSDFVTSTYRDHVHALSKGVPAHKILNELYGNYYGSTNKGK 282
Query: 657 QMPVHYGSKHHNMV 698
+H SK +N +
Sbjct: 283 GGSMHIYSKENNFI 296
>UniRef50_Q12FH4 Cluster: Pyruvate dehydrogenase; n=37;
Bacteria|Rep: Pyruvate dehydrogenase - Polaromonas sp.
(strain JS666 / ATCC BAA-500)
Length = 337
Score = 35.1 bits (77), Expect = 1.8
Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 1/98 (1%)
Frame = +3
Query: 381 DKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIT*AAPRHSHRKIWSSV 557
DKA + + M+++ M++ + + +I ++ Y GEE + A R +
Sbjct: 17 DKAFALAVLAGMLRIRRMEEKCAQLYGEQKIRGFLHLYIGEEAVAVGALRALQPQDNVVA 76
Query: 558 QYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVH 671
YRE G L RG+ + ++ + YG E +GR +H
Sbjct: 77 TYREHGHALLRGLAMNGIMAEMYGKREGCSRGRGGSMH 114
>UniRef50_Q8YNY8 Cluster: Asr4421 protein; n=1; Nostoc sp. PCC
7120|Rep: Asr4421 protein - Anabaena sp. (strain PCC
7120)
Length = 71
Score = 33.9 bits (74), Expect = 4.2
Identities = 16/38 (42%), Positives = 24/38 (63%)
Frame = -2
Query: 185 FTIFVIDLFLTSLLLTSIACFQKSNTKVYDCTDSRKYC 72
F ++ +FL +L+TS+ +KSNT V+ T S KYC
Sbjct: 26 FMVYAKSIFL-KVLMTSVYSLKKSNTYVFTVTYSGKYC 62
>UniRef50_A7CXZ4 Cluster: Pyruvate dehydrogenase; n=1; Opitutaceae
bacterium TAV2|Rep: Pyruvate dehydrogenase - Opitutaceae
bacterium TAV2
Length = 365
Score = 33.5 bits (73), Expect = 5.6
Identities = 23/101 (22%), Positives = 43/101 (42%), Gaps = 1/101 (0%)
Frame = +3
Query: 375 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIT*AAPRHSHRKIWS 551
+L A I +Y+TMV++ ++ + + +I ++ Y G+E +
Sbjct: 30 DLTPAARIELYRTMVRIRRFEERSLRAYQAKKIGGFLHLYIGQEAVAVGCCSLMGEHDHV 89
Query: 552 SVQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHY 674
YR+ G + GM L+ + YG KG+ +HY
Sbjct: 90 ITAYRDHGHAIAVGMDTKALMAELYGKATGCSKGKGGSMHY 130
>UniRef50_A3ZN48 Cluster: Putative uncharacterized protein; n=1;
Blastopirellula marina DSM 3645|Rep: Putative
uncharacterized protein - Blastopirellula marina DSM
3645
Length = 254
Score = 33.5 bits (73), Expect = 5.6
Identities = 15/38 (39%), Positives = 23/38 (60%), Gaps = 1/38 (2%)
Frame = +2
Query: 578 VFIPRD-DCDGTCEPVLRKLRGSGERETDAGPLRKQAP 688
+++P D DG +P+L L G+GER TD ++K P
Sbjct: 55 LYLPTDYKADGESKPLLLFLHGAGERGTDLNQVKKHGP 92
>UniRef50_Q53610 Cluster: Branched-chain alpha-keto acid
dehydrogenase E1-alpha subunit; n=16;
Actinomycetales|Rep: Branched-chain alpha-keto acid
dehydrogenase E1-alpha subunit - Streptomyces
avermitilis
Length = 406
Score = 33.1 bits (72), Expect = 7.4
Identities = 22/79 (27%), Positives = 33/79 (41%)
Frame = +3
Query: 393 LINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREV 572
L +Y+ MV D QRQG + + + G+E + R + + YRE
Sbjct: 70 LRGLYRDMVLSRRFDAEATSLQRQGELGLWASMLGQEAAQIGSGRATRDDDYVFPTYREH 129
Query: 573 GVFLYRGMTVTELVNQCYG 629
GV RG+ T L+ G
Sbjct: 130 GVAWCRGVDPTNLLGMFRG 148
>UniRef50_A7GY08 Cluster: Ferric uptake regulation protein; n=2;
Campylobacter|Rep: Ferric uptake regulation protein -
Campylobacter curvus 525.92
Length = 147
Score = 33.1 bits (72), Expect = 7.4
Identities = 16/46 (34%), Positives = 27/46 (58%)
Frame = -1
Query: 177 ICYRSFSHITTFDIDSLFSKIQYKSLRLH*FSKILLFIQNSTLCSS 40
I YRS +H++ DI + FSKI +++ L +L F+ LC++
Sbjct: 32 ILYRSQTHLSAQDIQTEFSKIHAQNISLPTIYALLNFLDECRLCNT 77
>UniRef50_A3S1N4 Cluster: Putative uncharacterized protein; n=1;
Prochlorococcus marinus str. MIT 9211|Rep: Putative
uncharacterized protein - Prochlorococcus marinus str.
MIT 9211
Length = 263
Score = 33.1 bits (72), Expect = 7.4
Identities = 17/51 (33%), Positives = 26/51 (50%)
Frame = -2
Query: 173 VIDLFLTSLLLTSIACFQKSNTKVYDCTDSRKYCCSYKIQLYVHPSSPSKS 21
++DL TS LL A F+ T++ + + + CC Y I L + PS S
Sbjct: 12 LLDLSKTSQLLAIKAEFEAEGTRIEELSVLSQLCCKYSIPLTLKVGGPSAS 62
>UniRef50_A0JUQ5 Cluster: Pyruvate dehydrogenase; n=4;
Actinobacteria (class)|Rep: Pyruvate dehydrogenase -
Arthrobacter sp. (strain FB24)
Length = 392
Score = 33.1 bits (72), Expect = 7.4
Identities = 20/78 (25%), Positives = 35/78 (44%)
Frame = +3
Query: 399 NMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGV 578
++Y+ MV + +D QRQG + + G+E + R + YRE GV
Sbjct: 60 SLYEDMVVIRRIDTEATALQRQGELGLWPPLLGQEASQIGSARSLRDDDFVFSSYRENGV 119
Query: 579 FLYRGMTVTELVNQCYGN 632
RG+ + +++ GN
Sbjct: 120 AYCRGVDLADILKVWRGN 137
>UniRef50_Q5DY55 Cluster: Putative uncharacterized protein; n=1;
Vibrio fischeri ES114|Rep: Putative uncharacterized
protein - Vibrio fischeri (strain ATCC 700601 / ES114)
Length = 147
Score = 32.7 bits (71), Expect = 9.7
Identities = 20/52 (38%), Positives = 29/52 (55%), Gaps = 1/52 (1%)
Frame = +3
Query: 342 NGQIIDKNEEPNLDKATLINMY-KTMVQLSHMDKILYESQRQGRISFYMTNY 494
N II K EE ++DK LI +Y KT L+ + K ++ S R G +S N+
Sbjct: 76 NKTIIVKKEERSVDKQKLIFLYKKTSNNLNQLAKQIHTSNRAGTLSREKMNH 127
>UniRef50_Q2J998 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp.
CcI3|Rep: Pyruvate dehydrogenase - Frankia sp. (strain
CcI3)
Length = 417
Score = 32.7 bits (71), Expect = 9.7
Identities = 23/106 (21%), Positives = 44/106 (41%), Gaps = 1/106 (0%)
Frame = +3
Query: 327 RVMDNNGQII-DKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 503
R++ +G ++ D D + Y +MV +D+ QRQG + ++ G+E
Sbjct: 52 RLLAPDGSLVADSRFSVLADHELRMEFYTSMVLARRLDEEATALQRQGELVLWIPLRGQE 111
Query: 504 GIT*AAPRHSHRKIWSSVQYREVGVFLYRGMTVTELVNQCYGNCED 641
+ + + + YRE V +RG+ E++ G D
Sbjct: 112 AAQVGSAAAARPRDYLFPSYREHAVAWHRGVPAVEVIRLLRGVSHD 157
>UniRef50_Q02C52 Cluster: Pyruvate dehydrogenase; n=1; Solibacter
usitatus Ellin6076|Rep: Pyruvate dehydrogenase -
Solibacter usitatus (strain Ellin6076)
Length = 340
Score = 32.7 bits (71), Expect = 9.7
Identities = 25/103 (24%), Positives = 46/103 (44%), Gaps = 1/103 (0%)
Frame = +3
Query: 402 MYKTMVQLSHMDKILYESQRQGRI-SFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGV 578
+Y ++ D+I + RQG+I G+E I + + + +R++ V
Sbjct: 30 LYYMLLMREVEDRIERKLYRQGKILGGVYVGRGQEAIPVGSALVAVPEDVMFPSHRDMAV 89
Query: 579 FLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTII 707
F RG++ ++ Q G +GR +H G N+V+II
Sbjct: 90 FFIRGVSARRVLAQYMGRLGGLTRGRDGNMHMGDMSVNVVSII 132
>UniRef50_A3EK78 Cluster: Putative uncharacterized protein; n=1;
Vibrio cholerae V51|Rep: Putative uncharacterized
protein - Vibrio cholerae V51
Length = 327
Score = 32.7 bits (71), Expect = 9.7
Identities = 27/126 (21%), Positives = 58/126 (46%), Gaps = 2/126 (1%)
Frame = +3
Query: 243 SRISG--ARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTM 416
S+++G AR P V +F+E++ + P Y D ID+ +++A N+
Sbjct: 8 SQVTGRPARKPRVGTRGYFSESNDQAAPSYPGQDWFNDCIDEFANA-MEQA---NIPYDP 63
Query: 417 VQLSHMDKILYESQRQGRISFYMTNYGEEGIT*AAPRHSHRKIWSSVQYREVGVFLYRGM 596
+L H+ + + E++ EEG++ A + + +++ + +GV Y +
Sbjct: 64 QRLDHLARAIAEAKANWEADIVSQAEAEEGLSATARKWTAQRVHQAFNKFGIGVAAYESV 123
Query: 597 TVTELV 614
V +L+
Sbjct: 124 LVADLL 129
>UniRef50_O64493 Cluster: F20D22.9 protein; n=5; Magnoliophyta|Rep:
F20D22.9 protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 838
Score = 32.7 bits (71), Expect = 9.7
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 3/50 (6%)
Frame = -2
Query: 725 CSLMELDNCD---HVVVLASVMDRHLSPFPRILAVSVTLVHKFRHSHPSV 585
CS+++ D C H VL S M H SP R LA V V + PS+
Sbjct: 573 CSILKSDKCRLTIHHAVLCSEMGAHFSPCGRYLAACVACVIPHAETDPSL 622
>UniRef50_A2FMN4 Cluster: ImpB/MucB/SamB family protein; n=1;
Trichomonas vaginalis G3|Rep: ImpB/MucB/SamB family
protein - Trichomonas vaginalis G3
Length = 519
Score = 32.7 bits (71), Expect = 9.7
Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 5/80 (6%)
Frame = +2
Query: 461 TRPHF-ILYDQLRRG----GHHIGSASALSPKDLVFSSIQRSRSVFIPRDDCDGTCEPVL 625
T+PH I+Y+Q + G + I S + KD + +Q+ RS +CD T +
Sbjct: 2 TQPHAGIIYNQAKAGLTSNSNDIASKVYDASKDTRYFQLQKERS-----KNCDATVSKIK 56
Query: 626 RKLRGSGERETDAGPLRKQA 685
KLR +G E D + +A
Sbjct: 57 EKLRSTGAAEMDFAAYQVEA 76
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 795,844,090
Number of Sequences: 1657284
Number of extensions: 17030891
Number of successful extensions: 46733
Number of sequences better than 10.0: 75
Number of HSP's better than 10.0 without gapping: 44835
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 46671
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 60500186565
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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