Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= tesS0989
(698 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI00015B4FA0 Cluster: PREDICTED: similar to chromatin ... 160 3e-38
UniRef50_Q8IRR5 Cluster: CG3187-PC, isoform C; n=4; Diptera|Rep:... 157 3e-37
UniRef50_UPI0000519F58 Cluster: PREDICTED: similar to Sirt4 CG31... 148 1e-34
UniRef50_A0Z2E4 Cluster: NAD-dependent deacetylase; n=1; marine ... 130 3e-29
UniRef50_Q1YSP9 Cluster: NAD-dependent deacetylase; n=1; gamma p... 129 7e-29
UniRef50_Q1D9X2 Cluster: Sir2 family protein; n=1; Myxococcus xa... 127 3e-28
UniRef50_A7SK95 Cluster: Predicted protein; n=1; Nematostella ve... 122 6e-27
UniRef50_Q8R216 Cluster: NAD-dependent deacetylase sirtuin-4; n=... 121 1e-26
UniRef50_A4A8B4 Cluster: Silent information regulator protein Si... 118 1e-25
UniRef50_A3WK56 Cluster: SIR2-like regulatory protein, NAD-depen... 116 6e-25
UniRef50_A3JEV2 Cluster: NAD-dependent deacetylase; n=2; Marinob... 115 1e-24
UniRef50_Q7WLE5 Cluster: NAD-dependent deacetylase; n=47; Bacter... 115 1e-24
UniRef50_Q9FY91 Cluster: SIR2-family protein; n=12; Magnoliophyt... 114 2e-24
UniRef50_Q9Y6E7 Cluster: NAD-dependent deacetylase sirtuin-4; n=... 114 2e-24
UniRef50_Q89EA6 Cluster: NAD-dependent deacetylase 2; n=9; Prote... 113 3e-24
UniRef50_A6FYM4 Cluster: Sir2 family protein; n=1; Plesiocystis ... 113 4e-24
UniRef50_Q9RL35 Cluster: NAD-dependent deacetylase 1; n=8; Actin... 113 4e-24
UniRef50_A0PU12 Cluster: Sir2-like regulatory protein; n=1; Myco... 110 4e-23
UniRef50_Q8FUC8 Cluster: NAD-dependent deacetylase 1; n=6; Coryn... 104 2e-21
UniRef50_Q1RPU9 Cluster: Zinc finger protein; n=1; Ciona intesti... 103 4e-21
UniRef50_A0JXS0 Cluster: Silent information regulator protein Si... 100 3e-20
UniRef50_A6WG46 Cluster: Silent information regulator protein Si... 97 4e-19
UniRef50_Q7PS76 Cluster: ENSANGP00000025231; n=1; Anopheles gamb... 94 3e-18
UniRef50_Q882K4 Cluster: NAD-dependent deacetylase 3; n=5; Pseud... 94 3e-18
UniRef50_Q7JMD3 Cluster: Putative uncharacterized protein sir-2.... 91 2e-17
UniRef50_Q8R984 Cluster: NAD-dependent deacetylase 2; n=1; Therm... 70 3e-16
UniRef50_Q2YZT2 Cluster: Putative uncharacterized protein; n=1; ... 67 2e-15
UniRef50_Q6AF12 Cluster: Regulatory protein, Sir2 family; n=2; A... 85 2e-15
UniRef50_UPI000050FCF4 Cluster: COG0846: NAD-dependent protein d... 83 6e-15
UniRef50_A1HLU5 Cluster: Silent information regulator protein Si... 83 6e-15
UniRef50_Q974M6 Cluster: NAD-dependent deacetylase; n=8; Thermop... 64 1e-14
UniRef50_Q55PY8 Cluster: Putative uncharacterized protein; n=2; ... 81 3e-14
UniRef50_Q5KZE8 Cluster: NAD-dependent deacetylase 2; n=3; Bacte... 67 4e-14
UniRef50_A7HL19 Cluster: Silent information regulator protein Si... 61 4e-14
UniRef50_Q73KE1 Cluster: NAD-dependent deacetylase; n=1; Trepone... 60 5e-14
UniRef50_UPI000049979A Cluster: Sir2 family transcriptional regu... 80 6e-14
UniRef50_Q2LSF2 Cluster: Sir2 family of NAD+-dependent deacetyla... 79 8e-14
UniRef50_Q4QB33 Cluster: Sir2-family protein-like protein; n=4; ... 78 2e-13
UniRef50_Q8ZU41 Cluster: NAD-dependent deacetylase 1; n=3; Pyrob... 62 2e-13
UniRef50_A6DC77 Cluster: Silent information regulator protein Si... 67 2e-13
UniRef50_Q81NT6 Cluster: NAD-dependent deacetylase; n=11; Bacill... 62 2e-13
UniRef50_A6PTK3 Cluster: Silent information regulator protein Si... 58 2e-13
UniRef50_Q12Y78 Cluster: Silent information regulator protein Si... 62 3e-13
UniRef50_UPI0000D55B5A Cluster: PREDICTED: similar to CG5216-PA;... 75 1e-12
UniRef50_A5UYK2 Cluster: Silent information regulator protein Si... 58 2e-12
UniRef50_Q8U1Q1 Cluster: NAD-dependent deacetylase; n=19; cellul... 75 2e-12
UniRef50_Q8ZT00 Cluster: NAD-dependent deacetylase 2; n=2; cellu... 60 3e-12
UniRef50_A7DQD6 Cluster: Silent information regulator protein Si... 63 3e-12
UniRef50_Q9WYW0 Cluster: NAD-dependent deacetylase; n=4; Thermot... 74 4e-12
UniRef50_A4M603 Cluster: Silent information regulator protein Si... 73 5e-12
UniRef50_A4J646 Cluster: Silent information regulator protein Si... 57 3e-11
UniRef50_Q97MB4 Cluster: NAD-dependent deacetylase; n=7; Bacteri... 58 4e-11
UniRef50_A2QUR5 Cluster: Remark: the H. sapiens SIRT4 belongs to... 70 5e-11
UniRef50_Q8G465 Cluster: Sir2-type regulatory protein; n=2; Bifi... 68 2e-10
UniRef50_Q8CNF4 Cluster: NAD-dependent deacetylase; n=17; Staphy... 57 2e-10
UniRef50_Q21921 Cluster: NAD-dependent deacetylase SIR2 homolog;... 54 3e-10
UniRef50_UPI0000D578DC Cluster: PREDICTED: similar to sirtuin 5 ... 67 4e-10
UniRef50_UPI000049971A Cluster: Sir2 family transcriptional regu... 66 6e-10
UniRef50_A1A3R7 Cluster: Sir2-type regulatory protein; n=2; Bifi... 66 8e-10
UniRef50_Q5YR82 Cluster: Putative Sir2 family regulator; n=1; No... 66 1e-09
UniRef50_O94640 Cluster: NAD-dependent histone deacetylase sir2;... 66 1e-09
UniRef50_O07595 Cluster: NAD-dependent deacetylase; n=3; Bacillu... 66 1e-09
UniRef50_A1I9S7 Cluster: NAD-dependent deacetylase; n=1; Candida... 65 2e-09
UniRef50_O96505 Cluster: SIR2; n=4; Sophophora|Rep: SIR2 - Droso... 65 2e-09
UniRef50_A5K7T7 Cluster: NAD-dependent deacetylase, putative; n=... 65 2e-09
UniRef50_A2Q9C4 Cluster: Contig An01c0250, complete genome; n=18... 64 2e-09
UniRef50_Q5L014 Cluster: NAD-dependent deacetylase 1; n=7; Bacil... 64 2e-09
UniRef50_Q3A6W7 Cluster: NAD-dependent protein deacetylases, SIR... 64 4e-09
UniRef50_UPI00015B57C0 Cluster: PREDICTED: similar to GA18743-PA... 63 6e-09
UniRef50_Q54GV7 Cluster: NAD(+)-dependent deacetylase, silent in... 63 7e-09
UniRef50_Q9NXA8 Cluster: NAD-dependent deacetylase sirtuin-5; n=... 63 7e-09
UniRef50_UPI00006CB0CC Cluster: transcriptional regulator, Sir2 ... 62 1e-08
UniRef50_Q5V4Q5 Cluster: NAD-dependent deacetylase; n=2; Halobac... 62 2e-08
UniRef50_A6P1S7 Cluster: Putative uncharacterized protein; n=2; ... 61 2e-08
UniRef50_A0LG97 Cluster: Silent information regulator protein Si... 61 2e-08
UniRef50_Q1RPU3 Cluster: Zinc finger protein; n=1; Ciona intesti... 61 3e-08
UniRef50_Q2U9Y7 Cluster: Sirtuin 4 and related class II sirtuins... 60 4e-08
UniRef50_Q3F1F4 Cluster: SIR2 family protein; n=1; Bacillus thur... 60 7e-08
UniRef50_A1FG80 Cluster: Silent information regulator protein Si... 59 9e-08
UniRef50_Q4WET3 Cluster: SIR2 family histone deacetylase, putati... 59 9e-08
UniRef50_Q8F3Z6 Cluster: NAD-dependent deacetylase; n=4; Leptosp... 59 9e-08
UniRef50_A7RLD5 Cluster: Predicted protein; n=1; Nematostella ve... 59 1e-07
UniRef50_Q899G3 Cluster: NAD-dependent deacetylase; n=19; cellul... 58 2e-07
UniRef50_Q07FY7 Cluster: Sirtuin (Silent mating type information... 58 2e-07
UniRef50_Q4P1X1 Cluster: Putative uncharacterized protein; n=1; ... 58 2e-07
UniRef50_A1DG07 Cluster: SIR2 family histone deacetylase, putati... 41 3e-07
UniRef50_Q011Q8 Cluster: NAD-dependent deacetylase SIRT2; n=2; O... 39 3e-07
UniRef50_A7RMK8 Cluster: Predicted protein; n=5; Eumetazoa|Rep: ... 58 3e-07
UniRef50_A6LP94 Cluster: Silent information regulator protein Si... 57 4e-07
UniRef50_Q88BY5 Cluster: NAD-dependent deacetylase; n=9; Bacteri... 57 4e-07
UniRef50_Q5BVX8 Cluster: SJCHGC08739 protein; n=1; Schistosoma j... 57 5e-07
UniRef50_A3LN35 Cluster: NAD-dependent histone deacetylase SIR2;... 57 5e-07
UniRef50_Q9NTG7 Cluster: NAD-dependent deacetylase sirtuin-3, mi... 45 6e-07
UniRef50_A7SX90 Cluster: Predicted protein; n=3; Eumetazoa|Rep: ... 56 6e-07
UniRef50_Q6FKU1 Cluster: Similar to sp|P53686 Saccharomyces cere... 56 6e-07
UniRef50_Q6BPH5 Cluster: Debaryomyces hansenii chromosome E of s... 56 6e-07
UniRef50_A1HU63 Cluster: Silent information regulator protein Si... 56 8e-07
UniRef50_Q7RP35 Cluster: Sir2-like protein; n=5; Plasmodium (Vin... 56 8e-07
UniRef50_A3ZMQ7 Cluster: Sir2 family, possible ADP ribosyltransf... 56 1e-06
UniRef50_Q8REC3 Cluster: NAD-dependent deacetylase; n=3; Fusobac... 56 1e-06
UniRef50_A6TNA0 Cluster: Silent information regulator protein Si... 55 1e-06
UniRef50_Q8IKW2 Cluster: Putative uncharacterized protein; n=1; ... 55 1e-06
UniRef50_Q5KDE0 Cluster: NAD-dependent histone deacetylase, puta... 55 1e-06
UniRef50_Q67KQ0 Cluster: NAD-dependent deacetylase; n=1; Symbiob... 55 1e-06
UniRef50_Q8A3H9 Cluster: NAD-dependent deacetylase; n=3; Bactero... 55 1e-06
UniRef50_Q4UH74 Cluster: Sir2-like histone deacetylase, putative... 55 2e-06
UniRef50_A7EC18 Cluster: Putative uncharacterized protein; n=1; ... 55 2e-06
UniRef50_P06700 Cluster: NAD-dependent histone deacetylase SIR2;... 55 2e-06
UniRef50_A7B9E8 Cluster: Putative uncharacterized protein; n=1; ... 54 3e-06
UniRef50_Q0AY57 Cluster: Regulatory protein, sir2 family; n=1; S... 54 3e-06
UniRef50_Q8ZFR1 Cluster: NAD-dependent deacetylase; n=149; cellu... 48 4e-06
UniRef50_Q0LIC7 Cluster: Silent information regulator protein Si... 40 4e-06
UniRef50_UPI0000E49846 Cluster: PREDICTED: similar to Sirtuin (s... 54 4e-06
UniRef50_A7EMW8 Cluster: Putative uncharacterized protein; n=1; ... 54 4e-06
UniRef50_A6RXY5 Cluster: Putative uncharacterized protein; n=2; ... 54 4e-06
UniRef50_Q8R104 Cluster: NAD-dependent deacetylase sirtuin-3; n=... 42 5e-06
UniRef50_A2F9H1 Cluster: Transcriptional regulator, Sir2 family ... 53 6e-06
UniRef50_A5DJ74 Cluster: Putative uncharacterized protein; n=1; ... 53 6e-06
UniRef50_Q9JN05 Cluster: NAD-dependent deacetylase; n=13; Campyl... 53 6e-06
UniRef50_Q0LFI4 Cluster: Silent information regulator protein Si... 53 8e-06
UniRef50_O25849 Cluster: NAD-dependent deacetylase; n=11; Bacter... 53 8e-06
UniRef50_A5K3P4 Cluster: Putative uncharacterized protein; n=1; ... 52 1e-05
UniRef50_A4VDQ9 Cluster: Chromatin regulatory protein sir2; n=1;... 52 1e-05
UniRef50_Q5AQ47 Cluster: Potential Sir2 family histone deacetyla... 52 1e-05
UniRef50_A5DSX8 Cluster: NAD-dependent histone deacetylase SIR2;... 52 1e-05
UniRef50_Q5P3W1 Cluster: NAD-dependent deacetylase 2; n=4; Prote... 52 1e-05
UniRef50_A5AF92 Cluster: Putative uncharacterized protein; n=1; ... 52 1e-05
UniRef50_UPI00004997CB Cluster: Sir2 family transcriptional regu... 52 2e-05
UniRef50_A0NQ49 Cluster: Silent information regulator protein Si... 52 2e-05
UniRef50_Q54QE6 Cluster: Zn finger-containing protein; n=5; Euka... 51 2e-05
UniRef50_Q54P49 Cluster: Zn finger-containing protein; n=1; Dict... 51 2e-05
UniRef50_Q4WFZ3 Cluster: SIR2 family histone deacetylase, putati... 51 2e-05
UniRef50_A6RRE3 Cluster: Putative uncharacterized protein; n=1; ... 51 2e-05
UniRef50_A4QX96 Cluster: Putative uncharacterized protein; n=2; ... 43 3e-05
UniRef50_Q7SB01 Cluster: Putative uncharacterized protein NCU076... 51 3e-05
UniRef50_A4QUX8 Cluster: Putative uncharacterized protein; n=1; ... 51 3e-05
UniRef50_Q9FE17 Cluster: Sir2-like protein; n=9; Magnoliophyta|R... 50 4e-05
UniRef50_Q298C7 Cluster: GA18650-PA; n=1; Drosophila pseudoobscu... 50 4e-05
UniRef50_Q607X6 Cluster: NAD-dependent deacetylase; n=1; Methylo... 50 4e-05
UniRef50_Q88ZA0 Cluster: NAD-dependent deacetylase; n=4; Lactoba... 50 4e-05
UniRef50_Q95Q89 Cluster: Yeast sir related protein 2.4; n=2; Cae... 50 5e-05
UniRef50_Q89LY4 Cluster: NAD-dependent deacetylase 1; n=12; Prot... 50 5e-05
UniRef50_Q6C219 Cluster: Yarrowia lipolytica chromosome F of str... 50 7e-05
UniRef50_Q8IXJ6 Cluster: NAD-dependent deacetylase sirtuin-2; n=... 50 7e-05
UniRef50_UPI000051AA14 Cluster: PREDICTED: similar to NAD-depend... 49 1e-04
UniRef50_Q8N6T7-2 Cluster: Isoform 2 of Q8N6T7 ; n=5; Catarrhini... 49 1e-04
UniRef50_Q1QTH0 Cluster: Silent information regulator protein Si... 49 1e-04
UniRef50_Q8N6T7 Cluster: Mono-ADP-ribosyltransferase sirtuin-6; ... 49 1e-04
UniRef50_Q9I4L0 Cluster: NAD-dependent deacetylase 1; n=10; Bact... 49 1e-04
UniRef50_Q0CR31 Cluster: NAD-dependent histone deacetylase SIR2;... 49 1e-04
UniRef50_Q8Y015 Cluster: NAD-dependent deacetylase; n=11; Bacter... 49 1e-04
UniRef50_Q8CJM9 Cluster: NAD-dependent deacetylase 2; n=3; Actin... 49 1e-04
UniRef50_Q4APN6 Cluster: Silent information regulator protein Si... 48 2e-04
UniRef50_Q9VH08 Cluster: CG6284-PA; n=9; Eumetazoa|Rep: CG6284-P... 48 2e-04
UniRef50_Q839C6 Cluster: NAD-dependent deacetylase; n=14; Bacill... 48 2e-04
UniRef50_UPI0000E49AD8 Cluster: PREDICTED: similar to NAD-depend... 48 2e-04
UniRef50_Q9CBW6 Cluster: NAD-dependent deacetylase; n=14; Mycoba... 48 2e-04
UniRef50_Q22KA8 Cluster: Transcriptional regulator, Sir2 family ... 48 3e-04
UniRef50_Q7S6G9 Cluster: Putative uncharacterized protein NCU047... 48 3e-04
UniRef50_Q6CAJ8 Cluster: Similar to sp|P53687 Saccharomyces cere... 48 3e-04
UniRef50_Q7ZVK3 Cluster: NAD-dependent deacetylase sirtuin-2; n=... 48 3e-04
UniRef50_UPI0000499DEA Cluster: Sir2 family transcriptional regu... 47 4e-04
UniRef50_A1CD03 Cluster: SIR2 family histone deacetylase, putati... 47 4e-04
UniRef50_Q96EB6 Cluster: NAD-dependent deacetylase sirtuin-1; n=... 47 4e-04
UniRef50_A2F8N6 Cluster: Transcriptional regulator, Sir2 family ... 35 4e-04
UniRef50_A7H7B6 Cluster: Silent information regulator protein Si... 47 5e-04
UniRef50_Q4P3S4 Cluster: Putative uncharacterized protein; n=1; ... 47 5e-04
UniRef50_A1ZZG3 Cluster: NAD-dependent deacetylase; n=35; Bacter... 46 7e-04
UniRef50_Q046W9 Cluster: NAD-dependent protein deacetylase, SIR2... 46 9e-04
UniRef50_Q23E36 Cluster: Transcriptional regulator, Sir2 family ... 46 9e-04
UniRef50_Q9USN7 Cluster: Sir2 family histone deacetylase Hst2; n... 46 9e-04
UniRef50_Q0UNC9 Cluster: Putative uncharacterized protein; n=1; ... 46 9e-04
UniRef50_O59923 Cluster: NAD-dependent histone deacetylase SIR2;... 46 9e-04
UniRef50_UPI00006CA40C Cluster: transcriptional regulator, Sir2 ... 46 0.001
UniRef50_Q3E2I1 Cluster: Silent information regulator protein Si... 46 0.001
UniRef50_Q6C8V5 Cluster: Similar to tr|Q9FY91 Arabidopsis thalia... 46 0.001
UniRef50_Q6MJJ2 Cluster: NAD-dependent deacetylase; n=5; Proteob... 46 0.001
UniRef50_Q1D737 Cluster: NAD-dependent deacetylase; n=1; Myxococ... 45 0.002
UniRef50_Q0LN22 Cluster: Silent information regulator protein Si... 44 0.003
UniRef50_Q175I4 Cluster: Chromatin regulatory protein sir2; n=3;... 44 0.003
UniRef50_A6XDL2 Cluster: Sirtuin 1; n=2; Schistosoma|Rep: Sirtui... 44 0.003
UniRef50_Q5KA61 Cluster: Histone deacetylase, putative; n=1; Fil... 44 0.003
UniRef50_O94066 Cluster: Transcription regulatory protein; n=6; ... 44 0.003
UniRef50_Q1RL71 Cluster: Zinc finger protein; n=2; Ciona intesti... 44 0.004
UniRef50_Q6CQA7 Cluster: Kluyveromyces lactis strain NRRL Y-1140... 44 0.004
UniRef50_A1ZPG8 Cluster: NAD-dependent deacetylase; n=1; Microsc... 44 0.005
UniRef50_A2GAR7 Cluster: Transcriptional regulator, Sir2 family ... 44 0.005
UniRef50_Q9I4E1 Cluster: NAD-dependent deacetylase 2; n=6; Pseud... 44 0.005
UniRef50_A0C2R2 Cluster: Chromosome undetermined scaffold_145, w... 43 0.006
UniRef50_A3LRA1 Cluster: Transcriptional regulatory protein; n=2... 43 0.008
UniRef50_A2DKF0 Cluster: Transcriptional regulator, Sir2 family ... 42 0.011
UniRef50_Q875P9 Cluster: HST1; n=1; Lachancea kluyveri|Rep: HST1... 42 0.011
UniRef50_A6G0H3 Cluster: Silent information regulator protein Si... 42 0.015
UniRef50_A2DZ01 Cluster: Transcriptional regulator, Sir2 family ... 42 0.015
UniRef50_Q9NRC8 Cluster: NAD-dependent deacetylase sirtuin-7; n=... 42 0.015
UniRef50_Q3V7G9 Cluster: Putative cobalamin biosynthetic protein... 42 0.019
UniRef50_A5USR3 Cluster: Silent information regulator protein Si... 42 0.019
UniRef50_A7AWG1 Cluster: Transcriptional regulator, Sir2 family ... 42 0.019
UniRef50_A4RCT8 Cluster: Putative uncharacterized protein; n=3; ... 41 0.025
UniRef50_Q55DB0 Cluster: NAD(+)-dependent deacetylase, silent in... 41 0.034
UniRef50_Q7SCL4 Cluster: Putative uncharacterized protein NCU005... 41 0.034
UniRef50_Q4PG00 Cluster: Putative uncharacterized protein; n=1; ... 41 0.034
UniRef50_Q25337 Cluster: NAD-dependent deacetylase SIR2 homolog;... 41 0.034
UniRef50_UPI0000D573CE Cluster: PREDICTED: similar to CG11305-PA... 40 0.044
UniRef50_A1ZHW6 Cluster: NAD-dependent deacetylase; n=2; Microsc... 40 0.044
UniRef50_Q7R0G2 Cluster: GLP_29_33086_34261; n=1; Giardia lambli... 40 0.059
UniRef50_Q7QZ36 Cluster: GLP_464_21655_23334; n=1; Giardia lambl... 40 0.059
UniRef50_A0C6J0 Cluster: Chromosome undetermined scaffold_152, w... 40 0.059
UniRef50_Q8FRV5 Cluster: NAD-dependent deacetylase 2; n=9; Coryn... 40 0.059
UniRef50_Q03ZB1 Cluster: NAD-dependent protein deacetylase, SIR2... 39 0.10
UniRef50_A5WD15 Cluster: Silent information regulator protein Si... 39 0.10
UniRef50_Q9VAQ1 Cluster: CG11305-PA; n=8; Coelomata|Rep: CG11305... 39 0.10
UniRef50_A6SP88 Cluster: Putative uncharacterized protein; n=2; ... 39 0.10
UniRef50_Q885X7 Cluster: NAD-dependent deacetylase 2; n=4; Pseud... 39 0.10
UniRef50_A1ZMS1 Cluster: Silent information regulator protein Si... 39 0.14
UniRef50_Q21KQ1 Cluster: Silent information regulator protein Si... 38 0.18
UniRef50_A0D0F1 Cluster: Chromosome undetermined scaffold_33, wh... 38 0.31
UniRef50_A2DKY5 Cluster: Transcriptional regulator, Sir2 family ... 37 0.41
UniRef50_Q7S223 Cluster: Putative uncharacterized protein NCU059... 37 0.41
UniRef50_Q9RYD4 Cluster: NAD-dependent deacetylase; n=4; Deinoco... 37 0.41
UniRef50_UPI00015B56BB Cluster: PREDICTED: similar to ENSANGP000... 37 0.55
UniRef50_Q4DP02 Cluster: Silent information regulator 2, putativ... 36 0.72
UniRef50_Q22ZC3 Cluster: Transcriptional regulator, Sir2 family ... 36 0.72
UniRef50_Q8SSB6 Cluster: SIR2-LIKE PROTEIN INVOLVED IN TELOMERIC... 36 0.72
UniRef50_Q75DM1 Cluster: ABL004Wp; n=1; Eremothecium gossypii|Re... 36 0.72
UniRef50_A5DNV7 Cluster: Putative uncharacterized protein; n=1; ... 36 0.72
UniRef50_A1CTI6 Cluster: SIR2 family histone deacetylase, putati... 36 0.72
UniRef50_Q5KPC9 Cluster: Hst3 protein, putative; n=2; Filobasidi... 36 0.96
UniRef50_A7TQE2 Cluster: Putative uncharacterized protein; n=1; ... 36 0.96
UniRef50_A2QFF9 Cluster: Complex: Sir2p is one of four Silent In... 36 0.96
UniRef50_A6Q2C0 Cluster: Transcriptional regulator, Sir2 family;... 36 1.3
UniRef50_Q6QGI5 Cluster: Putative Sir2-like protein; n=2; Entero... 36 1.3
UniRef50_A2QWZ2 Cluster: Function: human SIRT5 belongs to the Si... 35 1.7
UniRef50_Q7VIN2 Cluster: NAD-dependent deacetylase; n=1; Helicob... 35 1.7
UniRef50_UPI000023DCB3 Cluster: hypothetical protein FG05505.1; ... 35 2.2
UniRef50_A7HID4 Cluster: Silent information regulator protein Si... 35 2.2
UniRef50_A6DES9 Cluster: Transcriptional regulator, Sir2 family ... 35 2.2
UniRef50_Q754T1 Cluster: AFL010Cp; n=1; Eremothecium gossypii|Re... 35 2.2
UniRef50_P53687 Cluster: NAD-dependent histone deacetylase HST3;... 34 2.9
UniRef50_Q4S7H2 Cluster: Chromosome 13 SCAF14715, whole genome s... 33 5.1
UniRef50_A7TCJ5 Cluster: Predicted protein; n=2; Nematostella ve... 33 5.1
UniRef50_A2DZ29 Cluster: Transcriptional regulator, Sir2 family ... 33 5.1
UniRef50_UPI000023EE57 Cluster: hypothetical protein FG09358.1; ... 33 6.7
UniRef50_Q2KH01 Cluster: Putative uncharacterized protein; n=2; ... 33 6.7
UniRef50_A7BW37 Cluster: Putative uncharacterized protein; n=1; ... 33 8.9
UniRef50_Q7R0R8 Cluster: GLP_79_6121_4343; n=1; Giardia lamblia ... 33 8.9
UniRef50_A2F1E9 Cluster: Putative uncharacterized protein; n=1; ... 33 8.9
>UniRef50_UPI00015B4FA0 Cluster: PREDICTED: similar to chromatin
regulatory protein sir2; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to chromatin regulatory protein sir2 -
Nasonia vitripennis
Length = 736
Score = 160 bits (389), Expect = 3e-38
Identities = 76/174 (43%), Positives = 109/174 (62%)
Frame = +3
Query: 177 CEVSESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSE 356
C+ +++ + + L N TH ++ +E GKV+ ++TQNVD LH KAGS+
Sbjct: 516 CKSDKTRRRYWARNYAAWPRFSLFQPNVTHKWLKNMEDIGKVSCVITQNVDNLHIKAGSK 575
Query: 357 KVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNS 536
V+ELHGT Y V CL C +IDR QE+L + NPDM++S IRPDGDVD ++ +
Sbjct: 576 NVVELHGTGYRVVCLSCNNKIDRFVFQEVLNKLNPDMKASCEAIRPDGDVDLSQDQIDDF 635
Query: 537 ELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
++ G +KPDIVFFGDNVPK VE+V+ V +D++ V+G+SLT +S Y
Sbjct: 636 KIPPCSKCGGIMKPDIVFFGDNVPKQVVERVQNEVEEADSLLVLGTSLTTFSGY 689
Score = 86.6 bits (205), Expect = 5e-16
Identities = 39/75 (52%), Positives = 47/75 (62%)
Frame = +1
Query: 31 LNVFYTTHGVLCEVVH**S*WSLGIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYW 210
L F T G +C + GIPDYRSE VGL+A S+ +P+ YQ+F K K R+RYW
Sbjct: 467 LKHFVNTSGKICVITGAGISTESGIPDYRSEGVGLFATSDRRPVSYQDFCKSDKTRRRYW 526
Query: 211 ARNYIGWPRFSCVQP 255
ARNY WPRFS QP
Sbjct: 527 ARNYAAWPRFSLFQP 541
>UniRef50_Q8IRR5 Cluster: CG3187-PC, isoform C; n=4; Diptera|Rep:
CG3187-PC, isoform C - Drosophila melanogaster (Fruit
fly)
Length = 312
Score = 157 bits (380), Expect = 3e-37
Identities = 73/148 (49%), Positives = 98/148 (66%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N TH + E++ +V ++VTQNVDRLH KAGS V+E+HG+ Y+V+CL C Y IDRHE
Sbjct: 113 NATHHALARFEREERVQAVVTQNVDRLHTKAGSRNVVEVHGSGYVVKCLSCEYRIDRHEF 172
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
Q IL NP + + MIRPDGDV+ +N + G LKP+IVFFGD+VP+
Sbjct: 173 QSILASLNPAFKDAPDMIRPDGDVEIPLEYIENFRIPECTQCGGDLKPEIVFFGDSVPRP 232
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
RV+Q+ V +SD + V+GSSL V+S Y
Sbjct: 233 RVDQIAGMVYNSDGLLVLGSSLLVFSGY 260
Score = 97.9 bits (233), Expect = 2e-19
Identities = 41/67 (61%), Positives = 49/67 (73%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTSHISVFE 279
GIPDYRSE VGLYARSNHKP+Q+ EFVK VR+RYWARN++GWP+FS QP +
Sbjct: 61 GIPDYRSEGVGLYARSNHKPVQHMEFVKSSAVRKRYWARNFVGWPKFSATQPNATHHALA 120
Query: 280 N*RRREK 300
R E+
Sbjct: 121 RFEREER 127
>UniRef50_UPI0000519F58 Cluster: PREDICTED: similar to Sirt4
CG3187-PC, isoform C isoform 2; n=2; Endopterygota|Rep:
PREDICTED: similar to Sirt4 CG3187-PC, isoform C isoform
2 - Apis mellifera
Length = 302
Score = 148 bits (358), Expect = 1e-34
Identities = 69/148 (46%), Positives = 98/148 (66%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N TH + +LE K+ I+TQNVD LH KAGS+KVIELHGT++ V CL C I R+ L
Sbjct: 108 NNTHKILTKLENANKIRYIITQNVDNLHTKAGSKKVIELHGTAFRVMCLNCNERICRYYL 167
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
Q+I NP+M + MIRPDGDV+ + + ++ + G LKPDI+FFGDNVP+
Sbjct: 168 QDIFDRINPNMTVTSQMIRPDGDVELTQEQVEEFKVPICEKCDGILKPDIIFFGDNVPRK 227
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
VE ++ + SD++ ++G++LT +SSY
Sbjct: 228 IVENIKYNIEHSDSLLIIGTTLTTFSSY 255
Score = 93.9 bits (223), Expect = 3e-18
Identities = 37/54 (68%), Positives = 45/54 (83%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
GIPDYRSE VGLYARSNHKP+ Y++F +R+RYWARNYIGWPRFS ++P +
Sbjct: 56 GIPDYRSEGVGLYARSNHKPVLYKDFCNSDAIRRRYWARNYIGWPRFSSIKPNN 109
>UniRef50_A0Z2E4 Cluster: NAD-dependent deacetylase; n=1; marine
gamma proteobacterium HTCC2080|Rep: NAD-dependent
deacetylase - marine gamma proteobacterium HTCC2080
Length = 288
Score = 130 bits (314), Expect = 3e-29
Identities = 62/170 (36%), Positives = 98/170 (57%)
Frame = +3
Query: 189 ESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIE 368
ES+ + G+ + ++ N H + + E+ G+ T ++TQNVDRLH AGS+ VI+
Sbjct: 58 ESRQRYWGRSMIGWPNVRDARCNANHSALVDFEQSGRSTLVITQNVDRLHQAAGSQNVID 117
Query: 369 LHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHS 548
LHG V CL C +R +Q+ L E NP +M RPDGD D + ++ +
Sbjct: 118 LHGRLDRVVCLDCGAGYERDRVQQELEELNPQHRGFEAMARPDGDADLSAEQVRDVNIWD 177
Query: 549 AQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
+ G LKPD+VFFG +P+ RV + ++ +T++D + V+GSSL V+S +
Sbjct: 178 CEVCGGMLKPDVVFFGGTIPRERVTRCQEALTAADGLLVIGSSLQVFSGF 227
Score = 51.6 bits (118), Expect = 2e-05
Identities = 24/45 (53%), Positives = 31/45 (68%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWP 234
GIP YR G + R+ +PIQ+QEFV+ + RQRYW R+ IGWP
Sbjct: 31 GIPTYRDTS-GTWLRN--RPIQHQEFVQQRESRQRYWGRSMIGWP 72
>UniRef50_Q1YSP9 Cluster: NAD-dependent deacetylase; n=1; gamma
proteobacterium HTCC2207|Rep: NAD-dependent deacetylase
- gamma proteobacterium HTCC2207
Length = 270
Score = 129 bits (311), Expect = 7e-29
Identities = 64/148 (43%), Positives = 83/148 (56%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + LEK G V+ +VTQNVD LH +AGS+KVI+LHG V CL C + R L
Sbjct: 76 NGAHSALASLEKAGAVSCLVTQNVDGLHQRAGSQKVIDLHGRVDSVSCLSCKLRLPRAPL 135
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
Q L NNPD I PDGD D + ++ ++ G LKPD VFFGD+VP
Sbjct: 136 QTWLEANNPDFAKLAGAIAPDGDADVDNLDHSSMQVPDCENCGGVLKPDAVFFGDSVPAQ 195
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
RV + + +D + V+GSSL +S Y
Sbjct: 196 RVADAEQQMKDADGLVVVGSSLVAFSGY 223
Score = 45.6 bits (103), Expect = 0.001
Identities = 21/52 (40%), Positives = 31/52 (59%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
G+P YR++ G + R P+ +QEF + RQR+WARN +GW S +P
Sbjct: 27 GVPTYRNQR-GEWQRK--PPVTHQEFTGNHQARQRFWARNLVGWRFMSSARP 75
>UniRef50_Q1D9X2 Cluster: Sir2 family protein; n=1; Myxococcus
xanthus DK 1622|Rep: Sir2 family protein - Myxococcus
xanthus (strain DK 1622)
Length = 287
Score = 127 bits (306), Expect = 3e-28
Identities = 66/170 (38%), Positives = 88/170 (51%)
Frame = +3
Query: 189 ESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIE 368
E +A+ + L N H + ELE+ G V ++TQNVD LHH AGS +VIE
Sbjct: 69 EVRARYWARSLMGWPRFSSARPNAAHAALAELEQAGHVRGLITQNVDGLHHAAGSSRVIE 128
Query: 369 LHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHS 548
LHG V+CL C + R LQ L NP +RPDGD D + + ++ +
Sbjct: 129 LHGALAQVRCLACGAQEAREALQARLLSLNPGFSLEVLELRPDGDADLTSEQLSSFQVPA 188
Query: 549 AQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
G LKPD+VFFGDNVP V + DA+ V+GSSL ++S Y
Sbjct: 189 CLVCGGTLKPDVVFFGDNVPVPTVASAFALLEEGDALLVVGSSLAIFSGY 238
Score = 64.1 bits (149), Expect = 3e-09
Identities = 31/61 (50%), Positives = 43/61 (70%), Gaps = 1/61 (1%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP-TSHISVF 276
GIPDYR G AR+ + PIQ++EF+ P+VR RYWAR+ +GWPRFS +P +H ++
Sbjct: 42 GIPDYRGP--GTRARARN-PIQHREFLTRPEVRARYWARSLMGWPRFSSARPNAAHAALA 98
Query: 277 E 279
E
Sbjct: 99 E 99
>UniRef50_A7SK95 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 323
Score = 122 bits (295), Expect = 6e-27
Identities = 65/148 (43%), Positives = 88/148 (59%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + +LE G V S+VTQNVD LH KAGS+ VIELHG S+ V CL C R L
Sbjct: 128 NEAHYALAKLETLGSVHSLVTQNVDALHTKAGSKNVIELHGCSHRVICLGCNQITARTAL 187
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
Q+ + E NPD + PDGD K+ ++ ++ G LKP++VFFGD+VPK
Sbjct: 188 QKRMIEFNPDWHAVGQGQAPDGDTFLTSEAVKDFKVPPCKACGGILKPEVVFFGDSVPKQ 247
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
V + SDA++++GS++ VYSSY
Sbjct: 248 IVNIAYDRLAESDALWIIGSTVEVYSSY 275
Score = 77.4 bits (182), Expect = 3e-13
Identities = 32/52 (61%), Positives = 39/52 (75%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GI DYRSE GLYA +N +P++YQ F+K +RQRYWARNY+GWP F QP
Sbjct: 76 GIRDYRSEGKGLYAITNDRPMEYQVFLKSAVMRQRYWARNYVGWPEFGSRQP 127
>UniRef50_Q8R216 Cluster: NAD-dependent deacetylase sirtuin-4; n=7;
cellular organisms|Rep: NAD-dependent deacetylase
sirtuin-4 - Mus musculus (Mouse)
Length = 333
Score = 121 bits (292), Expect = 1e-26
Identities = 61/148 (41%), Positives = 85/148 (57%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + E+ GK+ +VTQNVD LH KAGS+++ ELHG + V CL C + R L
Sbjct: 119 NPAHWALSNWERLGKLHWLVTQNVDALHSKAGSQRLTELHGCMHRVLCLNCGEQTARRVL 178
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
QE NP + + PDGDV + ++ ++ GPLKPD+VFFGD V
Sbjct: 179 QERFQALNPSWSAEAQGVAPDGDVFLTEEQVRSFQVPCCDRCGGPLKPDVVFFGDTVNPD 238
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
+V+ V + V +D++ V+GSSL VYS Y
Sbjct: 239 KVDFVHRRVKEADSLLVVGSSLQVYSGY 266
Score = 84.6 bits (200), Expect = 2e-15
Identities = 38/68 (55%), Positives = 47/68 (69%)
Frame = +1
Query: 103 IPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTSHISVFEN 282
IPDYRSE VGLYAR++ +PIQ+ +FV+ VRQRYWARN++GWP+FS QP N
Sbjct: 68 IPDYRSEKVGLYARTDRRPIQHIDFVRSAPVRQRYWARNFVGWPQFSSHQPNPAHWALSN 127
Query: 283 *RRREK*H 306
R K H
Sbjct: 128 WERLGKLH 135
>UniRef50_A4A8B4 Cluster: Silent information regulator protein Sir2;
n=1; Congregibacter litoralis KT71|Rep: Silent
information regulator protein Sir2 - Congregibacter
litoralis KT71
Length = 297
Score = 118 bits (285), Expect = 1e-25
Identities = 63/145 (43%), Positives = 84/145 (57%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEI 443
H + +LE G V+ IVTQNVDRLH +AGS +V +LHG V+CL C R LQ+
Sbjct: 88 HRLLAQLEHHGLVSHIVTQNVDRLHQRAGSIRVTDLHGRLDRVRCLGCETLSSRDVLQKA 147
Query: 444 LTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVE 623
L NP + + RPDGD D + + S G L PD+VFFG ++P RVE
Sbjct: 148 LERLNPHINHTTIEARPDGDADMPDAMVEGITVPSCDLCDGTLMPDVVFFGGSIPGSRVE 207
Query: 624 QVRKXVTSSDAVFVMGSSLTVYSSY 698
Q ++ + S++V V+GSSL VYS Y
Sbjct: 208 QCKQVLEHSNSVLVVGSSLQVYSGY 232
Score = 54.0 bits (124), Expect = 3e-06
Identities = 27/54 (50%), Positives = 33/54 (61%)
Frame = +1
Query: 94 SLGIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
S GIP YR E G + RSN PI +QEFV + RQRYW R+ +GWP +P
Sbjct: 34 STGIPTYRDEK-GAWLRSN--PITHQEFVADRRQRQRYWGRSLLGWPAVRDAKP 84
>UniRef50_A3WK56 Cluster: SIR2-like regulatory protein,
NAD-dependent protein deacetylase; n=1; Idiomarina
baltica OS145|Rep: SIR2-like regulatory protein,
NAD-dependent protein deacetylase - Idiomarina baltica
OS145
Length = 279
Score = 116 bits (279), Expect = 6e-25
Identities = 58/148 (39%), Positives = 83/148 (56%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H I + ++ G + +++TQNVD LH KAGS VI LHG + + C+ C R +L
Sbjct: 83 NRAHQVIAQFQQHGFIDTVITQNVDGLHQKAGSSTVINLHGYANDIVCMTCGDRSPRFDL 142
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
+ E NP S S+I+PDGD + +H G LKPD+V+FGDNVPK
Sbjct: 143 HQRYAELNPRFNQSVSVIKPDGDAKLSAPTDEFKLIH-CDHCGGILKPDVVYFGDNVPKK 201
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
RVE + + S + ++GSSL V+S +
Sbjct: 202 RVEACYQAIDDSQGLLIVGSSLKVFSGF 229
Score = 39.1 bits (87), Expect = 0.10
Identities = 20/52 (38%), Positives = 28/52 (53%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIP YR+ G + S P+Q+ +F+ R+RYWAR+ GW QP
Sbjct: 34 GIPAYRNAQ-GQWVHS--PPMQHHDFMNNDAARKRYWARSLGGWLNLYHAQP 82
>UniRef50_A3JEV2 Cluster: NAD-dependent deacetylase; n=2;
Marinobacter|Rep: NAD-dependent deacetylase -
Marinobacter sp. ELB17
Length = 300
Score = 115 bits (277), Expect = 1e-24
Identities = 63/170 (37%), Positives = 93/170 (54%)
Frame = +3
Query: 189 ESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIE 368
+++ + G+ L ++ + N +H I +LE + +VTQNVDRLH KAG++ V +
Sbjct: 86 QTRQRYWGRSLIGWPLMRNASPNASHHHISQLEMLNHSSLVVTQNVDRLHQKAGTQAVTD 145
Query: 369 LHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHS 548
LHG + V C+ C Y R E+ + NP + + + PDGD D N + +L
Sbjct: 146 LHGRADEVLCMSCDYRCMRDEVHQRCAILNPQFSAFTADVAPDGDADLDINF-ADFQLAD 204
Query: 549 AQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
G LKPD+VFFGD VPK RV + +SD + V+GSSL VYS +
Sbjct: 205 CPVCGGILKPDVVFFGDYVPKQRVNAALDALKASDGLLVIGSSLMVYSGF 254
Score = 53.2 bits (122), Expect = 6e-06
Identities = 28/63 (44%), Positives = 36/63 (57%), Gaps = 3/63 (4%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS---HIS 270
GIPDYR D G + R +P+Q+Q F+ + RQRYW R+ IGWP P + HIS
Sbjct: 59 GIPDYRDGD-GAWKRK--QPVQHQAFMGSVQTRQRYWGRSLIGWPLMRNASPNASHHHIS 115
Query: 271 VFE 279
E
Sbjct: 116 QLE 118
>UniRef50_Q7WLE5 Cluster: NAD-dependent deacetylase; n=47;
Bacteria|Rep: NAD-dependent deacetylase - Bordetella
bronchiseptica (Alcaligenes bronchisepticus)
Length = 274
Score = 115 bits (276), Expect = 1e-24
Identities = 58/148 (39%), Positives = 83/148 (56%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + L ++G+V +VTQNVDRLH AG +V++LHG V+C++C + R
Sbjct: 83 NAAHHALARLAQRGQVDLLVTQNVDRLHQAAGGREVLDLHGRLDEVRCMQCDWRGPRGPW 142
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
Q L NP + + PDGD D G + S G +KPD+VFFG+ VP+
Sbjct: 143 QHTLELANPQWAALQAGAAPDGDADLEGQDFSRFVVPSCPRCGGIVKPDVVFFGETVPRE 202
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
RV++ + +DAV V+GSSL +YS Y
Sbjct: 203 RVQRAYAALEHADAVLVVGSSLMLYSGY 230
Score = 45.6 bits (103), Expect = 0.001
Identities = 22/54 (40%), Positives = 30/54 (55%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
GIPDYR + G + R PI +Q F+ R RYWAR+ +GW F +P +
Sbjct: 34 GIPDYR-DGQGQWKRK--PPIDFQAFMGGQPARARYWARSMVGWRHFGQARPNA 84
>UniRef50_Q9FY91 Cluster: SIR2-family protein; n=12;
Magnoliophyta|Rep: SIR2-family protein - Arabidopsis
thaliana (Mouse-ear cress)
Length = 451
Score = 114 bits (275), Expect = 2e-24
Identities = 64/163 (39%), Positives = 88/163 (53%), Gaps = 18/163 (11%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQ-- 437
H + LEK G++ ++TQNVDRLHH+AGS+ +ELHGT Y V CL+C + R Q
Sbjct: 237 HTALASLEKAGRINFMITQNVDRLHHRAGSDP-LELHGTVYTVMCLECGFSFPRDLFQDQ 295
Query: 438 --------------EILTENNPDMESSFSMI-RPDGDVDCRGNK*KNS-ELHSAQSVKGP 569
E + +P E SF M RPDGD++ + + + KG
Sbjct: 296 LKAINPKASWAEAIESIDHGDPGSEKSFGMKQRPDGDIEIDEKFWEEGFHIPVCEKCKGV 355
Query: 570 LKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
LKPD++FFGDN+PK R Q + SDA V+GSSL S++
Sbjct: 356 LKPDVIFFGDNIPKERATQAMEVAKQSDAFLVLGSSLMTMSAF 398
Score = 64.9 bits (151), Expect = 2e-09
Identities = 29/52 (55%), Positives = 37/52 (71%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYRS + G Y+ S KPI +QEF + + R+RYWAR+Y GW RF+ QP
Sbjct: 184 GIPDYRSPN-GAYS-SGFKPITHQEFTRSSRARRRYWARSYAGWRRFTAAQP 233
>UniRef50_Q9Y6E7 Cluster: NAD-dependent deacetylase sirtuin-4; n=23;
Deuterostomia|Rep: NAD-dependent deacetylase sirtuin-4 -
Homo sapiens (Human)
Length = 314
Score = 114 bits (275), Expect = 2e-24
Identities = 62/148 (41%), Positives = 83/148 (56%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + EK GK+ +VTQNVD LH KAGS ++ ELHG V CL C + R L
Sbjct: 122 NPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVL 181
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
QE NP + + PDGDV + ++ ++ + G LKPD+VFFGD V
Sbjct: 182 QERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPD 241
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
+V+ V K V +D++ V+GSSL VYS Y
Sbjct: 242 KVDFVHKRVKEADSLLVVGSSLQVYSGY 269
Score = 85.8 bits (203), Expect = 9e-16
Identities = 34/52 (65%), Positives = 44/52 (84%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYRSE VGLYAR++ +PIQ+ +FV+ +RQRYWARN++GWP+FS QP
Sbjct: 70 GIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQP 121
>UniRef50_Q89EA6 Cluster: NAD-dependent deacetylase 2; n=9;
Proteobacteria|Rep: NAD-dependent deacetylase 2 -
Bradyrhizobium japonicum
Length = 273
Score = 113 bits (273), Expect = 3e-24
Identities = 56/148 (37%), Positives = 86/148 (58%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + LE G+ ++TQNVDRLH AG +VI+LHG LV+C+ C + R E
Sbjct: 83 NDAHHALARLEANGRCGMLLTQNVDRLHQSAGHRQVIDLHGRLDLVRCMGCGAKTPRSEF 142
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
Q+ L N + + + PDGD D + ++ + ++ G LKPD+VFFG+NVP+
Sbjct: 143 QDTLGRANAEWLALDASDAPDGDADLEHADFSSFKVPACEACGGILKPDVVFFGENVPRD 202
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
V + ++ +DA+ ++GSSL VYS +
Sbjct: 203 VVATAQDHLSQADAMLIVGSSLMVYSGF 230
Score = 50.0 bits (114), Expect = 5e-05
Identities = 23/52 (44%), Positives = 32/52 (61%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYR G + R+ +P+ +Q F+ R+RYWAR+ IGW RF +P
Sbjct: 34 GIPDYRDSH-GNWKRT--QPVNFQAFMSEEHTRRRYWARSLIGWRRFGQARP 82
>UniRef50_A6FYM4 Cluster: Sir2 family protein; n=1; Plesiocystis
pacifica SIR-1|Rep: Sir2 family protein - Plesiocystis
pacifica SIR-1
Length = 297
Score = 113 bits (272), Expect = 4e-24
Identities = 61/175 (34%), Positives = 94/175 (53%)
Frame = +3
Query: 168 SRICEVSESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKA 347
S E E++A+ + + ++ N H + +LE G ++ ++TQNVDRLHH+A
Sbjct: 69 SAYVEDPEARARYWSRAVVGWPKLSRARPNAAHRVLAQLEAAGVLSGLITQNVDRLHHQA 128
Query: 348 GSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK* 527
GS V+ELHG V+CL C R LQ+ L NP + + PDGD + +
Sbjct: 129 GSRAVVELHGALAEVRCLSCQTIEGRDALQDRLLGLNPSWRHLDAAMAPDGDAELE-DPV 187
Query: 528 KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYS 692
++ Q+ G LKP++VFFG+ VP+ V+Q V ++ + V GSSL V+S
Sbjct: 188 DRFQVADCQACGGLLKPNVVFFGEQVPQATVDQAYAMVEDAEVLAVFGSSLAVFS 242
Score = 54.8 bits (126), Expect = 2e-06
Identities = 24/54 (44%), Positives = 36/54 (66%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
GIPDYR E G AR+ + PI++ +V+ P+ R RYW+R +GWP+ S +P +
Sbjct: 49 GIPDYRGE--GTRARARN-PIRFSAYVEDPEARARYWSRAVVGWPKLSRARPNA 99
>UniRef50_Q9RL35 Cluster: NAD-dependent deacetylase 1; n=8;
Actinomycetales|Rep: NAD-dependent deacetylase 1 -
Streptomyces coelicolor
Length = 299
Score = 113 bits (272), Expect = 4e-24
Identities = 61/146 (41%), Positives = 79/146 (54%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + + G +T ++TQNVD LH AGSE V+ELHG+ V CL C R EL
Sbjct: 96 NAGHRSVAAFGRHGLLTGVITQNVDGLHQAAGSEGVVELHGSLDRVVCLSCGVLSPRREL 155
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
L E N + I PDGD D + + + G LKPD+VFFG+NVP
Sbjct: 156 ARRLEEANAGFSPVAAGINPDGDADLTDEQVGDFRVVPCAVCGGVLKPDVVFFGENVPPR 215
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTVYS 692
RVE R+ V + ++ V+GSSLTV S
Sbjct: 216 RVEHCRELVRGASSLLVLGSSLTVMS 241
Score = 61.7 bits (143), Expect = 2e-08
Identities = 28/59 (47%), Positives = 38/59 (64%), Gaps = 1/59 (1%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS-HISV 273
GIPDYR E L S H P+ YQ+F +P+ R+RYWAR+++GW F +P + H SV
Sbjct: 47 GIPDYRGEGGSL---SRHTPMTYQDFTAHPEARRRYWARSHLGWRTFGRARPNAGHRSV 102
>UniRef50_A0PU12 Cluster: Sir2-like regulatory protein; n=1;
Mycobacterium ulcerans Agy99|Rep: Sir2-like regulatory
protein - Mycobacterium ulcerans (strain Agy99)
Length = 283
Score = 110 bits (264), Expect = 4e-23
Identities = 65/155 (41%), Positives = 86/155 (55%), Gaps = 5/155 (3%)
Frame = +3
Query: 249 ATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRH 428
A N H + LE+ G VT ++TQNVD LH KAGS+ V+ LHGT V CL C + I R
Sbjct: 73 APNAGHRALAALERAGVVTGVITQNVDLLHTKAGSKNVVNLHGTYAQVTCLGCGHTISRS 132
Query: 429 ELQEILTENNPD-MESSFSM----IRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFF 593
L L NP +E + ++ + PD D ++ + G LKPDIV+F
Sbjct: 133 TLAAELESLNPGFIERAEAVGGLAVAPDADAVIADT--ESFRYIDCRCCGGMLKPDIVYF 190
Query: 594 GDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
G++VPK V+Q V SDA+ V GSSLTV+S Y
Sbjct: 191 GESVPKEPVDQAFSLVDQSDALLVAGSSLTVFSGY 225
Score = 46.4 bits (105), Expect = 7e-04
Identities = 23/54 (42%), Positives = 29/54 (53%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
GIPDYR D SN P+ ++F P RQRYWARN++GW P +
Sbjct: 28 GIPDYRGPDS---PPSN--PMTIRQFTSDPVFRQRYWARNHVGWRHMDDTAPNA 76
>UniRef50_Q8FUC8 Cluster: NAD-dependent deacetylase 1; n=6;
Corynebacterium|Rep: NAD-dependent deacetylase 1 -
Corynebacterium efficiens
Length = 281
Score = 104 bits (250), Expect = 2e-21
Identities = 61/153 (39%), Positives = 83/153 (54%), Gaps = 5/153 (3%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N TH + ELE+ G ++ IVTQNVD LH +AGSE ++ LHG + CL+C + R L
Sbjct: 81 NRTHYALVELERAGLLSGIVTQNVDGLHRRAGSENLVALHGDLATIVCLQCGHREARELL 140
Query: 435 QEILTENNPDMESSF----SMIRPDGDVDCRGNK*KNSELHS-AQSVKGPLKPDIVFFGD 599
L NP S S + PDGDV + + + A+ LKPD+V+FG+
Sbjct: 141 DARLDHLNPGYFDSIALDPSAVNPDGDVTLDDHHVQRFTMAGCARCGSVLLKPDVVYFGE 200
Query: 600 NVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
VP R +V + + +DAV V GSSL V S Y
Sbjct: 201 PVPSIRKTRVAQLLDGADAVVVAGSSLAVMSGY 233
Score = 49.2 bits (112), Expect = 1e-04
Identities = 25/61 (40%), Positives = 35/61 (57%), Gaps = 1/61 (1%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPT-SHISVF 276
GIPDYRS L + +P+ YQEF P RYWAR+++GW + QP +H ++
Sbjct: 32 GIPDYRSPRGSL---NQGRPMTYQEFRFDPVASHRYWARSFVGWRVMADAQPNRTHYALV 88
Query: 277 E 279
E
Sbjct: 89 E 89
>UniRef50_Q1RPU9 Cluster: Zinc finger protein; n=1; Ciona
intestinalis|Rep: Zinc finger protein - Ciona
intestinalis (Transparent sea squirt)
Length = 320
Score = 103 bits (247), Expect = 4e-21
Identities = 62/172 (36%), Positives = 89/172 (51%), Gaps = 1/172 (0%)
Frame = +3
Query: 186 SESKAKVLGKKLYR-LAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKV 362
S K K+ + Y A+ N H+ + +EK G+V TQNVD L KAG+E++
Sbjct: 106 SADKRKIYWARSYLGWAKYNAWKPNAAHVKLAAMEKDGRVDWHTTQNVDGLMVKAGAEQL 165
Query: 363 IELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSEL 542
ELHG V C++C +DR+ +Q+ + E N + PD DV + +
Sbjct: 166 TELHGQMRRVVCMRCNGLLDRNVMQKDMDELNKHWSAEVLGYGPDADVFICEEDVIDFNV 225
Query: 543 HSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
+ + G LKP++ FFGDNVP +V VR V D V V+GSSL V+S Y
Sbjct: 226 PACRKCGGDLKPNVTFFGDNVPGSKVTFVRSIVDKCDGVLVVGSSLHVWSGY 277
Score = 83.0 bits (196), Expect = 6e-15
Identities = 33/59 (55%), Positives = 48/59 (81%), Gaps = 1/59 (1%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP-TSHISV 273
GIPDYRS+DVGLYAR+NHKP+Q+Q+FVK R+ YWAR+Y+GW +++ +P +H+ +
Sbjct: 78 GIPDYRSKDVGLYARTNHKPMQHQDFVKSADKRKIYWARSYLGWAKYNAWKPNAAHVKL 136
>UniRef50_A0JXS0 Cluster: Silent information regulator protein Sir2
precursor; n=11; Actinomycetales|Rep: Silent information
regulator protein Sir2 precursor - Arthrobacter sp.
(strain FB24)
Length = 306
Score = 100 bits (240), Expect = 3e-20
Identities = 60/152 (39%), Positives = 82/152 (53%), Gaps = 6/152 (3%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H LE++G +T ++TQNVDRLH AGS V++LHG V CL C R L
Sbjct: 104 NDGHAAAARLEQRGLLTGLITQNVDRLHEDAGSVNVVDLHGRFDRVACLSCARRYSRTLL 163
Query: 435 QEILTENNPD-MESSFS----MIRPDGDVDCRGNK-*KNSELHSAQSVKGPLKPDIVFFG 596
+L E NP +E + + + PD D + ++ + + G LKPD V+FG
Sbjct: 164 AGVLEELNPGFLEQALADGVVEMAPDADATVEDSALIRSFVVAHCPACGGTLKPDFVYFG 223
Query: 597 DNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYS 692
+NVPK RVE+ V + A+ V GSSLTV S
Sbjct: 224 ENVPKDRVERSYAMVDEAGALVVAGSSLTVMS 255
Score = 52.4 bits (120), Expect = 1e-05
Identities = 25/52 (48%), Positives = 29/52 (55%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYR D A P+ YQEF+ + RQRYWARN+IGW P
Sbjct: 57 GIPDYRGPDAAPRA-----PMTYQEFIGHAGNRQRYWARNHIGWSHLRRADP 103
>UniRef50_A6WG46 Cluster: Silent information regulator protein Sir2;
n=4; Actinomycetales|Rep: Silent information regulator
protein Sir2 - Kineococcus radiotolerans SRS30216
Length = 279
Score = 97.1 bits (231), Expect = 4e-19
Identities = 58/175 (33%), Positives = 89/175 (50%), Gaps = 4/175 (2%)
Frame = +3
Query: 186 SESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVI 365
+E++ + G+ + N H + LE G VT ++TQNVD L AG+ +V+
Sbjct: 55 AEARRRYWGRSHVGWEHFRRARPNDAHRAVAALEGAGVVTGVITQNVDGLDLAAGTREVV 114
Query: 366 ELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMES---SFSMIRPDGDVDCRGNK*KNS 536
ELHG V CL+C R EL E L+ NP ++ + PDGD D + +
Sbjct: 115 ELHGNLDRVVCLRCGELTARAELAERLSAANPGFDARVEQLHALNPDGDADLTEAQLEGF 174
Query: 537 ELHSAQSV-KGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
+ + + LK D+VFFG+ VPK RV + + + ++ + V+GSSL V S Y
Sbjct: 175 RTVACRRCGEDALKADVVFFGETVPKDRVARSFELLDAARVLLVLGSSLAVMSGY 229
Score = 51.6 bits (118), Expect = 2e-05
Identities = 22/52 (42%), Positives = 29/52 (55%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYR L H P+ YQEF + R+RYW R+++GW F +P
Sbjct: 29 GIPDYRGPGGSL---QRHTPMTYQEFTGSAEARRRYWGRSHVGWEHFRRARP 77
>UniRef50_Q7PS76 Cluster: ENSANGP00000025231; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000025231 - Anopheles gambiae
str. PEST
Length = 182
Score = 93.9 bits (223), Expect = 3e-18
Identities = 38/52 (73%), Positives = 44/52 (84%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYRSE VGLYARSNHKPIQ+ +FVK R+RYWARNY+GWP+FS + P
Sbjct: 14 GIPDYRSEGVGLYARSNHKPIQHGDFVKSEATRKRYWARNYVGWPKFSSIAP 65
Score = 77.4 bits (182), Expect = 3e-13
Identities = 50/146 (34%), Positives = 76/146 (52%)
Frame = +3
Query: 249 ATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRH 428
A N TH + LE++G+++ IVTQNVDRL HG +
Sbjct: 64 APNVTHYTLARLEREGRISGIVTQNVDRL------------HGKA--------------- 96
Query: 429 ELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
++++ + + + + +RPDGDV+ + ++ G LKP+IVFFGDNVP
Sbjct: 97 GSKQVIELHGSGFDDNSTSMRPDGDVELSMEYVQGFKIPPCPQCGGNLKPEIVFFGDNVP 156
Query: 609 KYRVEQVRKXVTSSDAVFVMGSSLTV 686
R+E+V + + SD V V+GSSLTV
Sbjct: 157 MPRIEKVVRMIIESDGVLVLGSSLTV 182
>UniRef50_Q882K4 Cluster: NAD-dependent deacetylase 3; n=5;
Pseudomonas|Rep: NAD-dependent deacetylase 3 -
Pseudomonas syringae pv. tomato
Length = 281
Score = 93.9 bits (223), Expect = 3e-18
Identities = 50/155 (32%), Positives = 80/155 (51%), Gaps = 1/155 (0%)
Frame = +3
Query: 237 IQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYE 416
I N H + L+ + + ++TQNVD LH +AGS+ VIELHG+ + V CL C
Sbjct: 78 ISASQANAAHRALAALQAENLIKGLITQNVDALHTQAGSQDVIELHGSLHRVLCLDCQQR 137
Query: 417 IDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGP-LKPDIVFF 593
DR +QE + +N + + PDGD ++ +G LKPD+VFF
Sbjct: 138 SDRTAIQEQMLAHNLYLADVHATQAPDGDTLLDPAYEAGFKVPECPHCQGKRLKPDVVFF 197
Query: 594 GDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
G+NV + + V ++ + V+G+SL +S++
Sbjct: 198 GENVASHTAARATLSVEQAEGLLVVGTSLMAWSAF 232
Score = 61.3 bits (142), Expect = 2e-08
Identities = 29/51 (56%), Positives = 34/51 (66%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQ 252
GIPDYR +D G+ R +P+ YQEFV P RQRYWAR +GWPR S Q
Sbjct: 35 GIPDYRDKD-GV--RRGAQPMMYQEFVGNPAARQRYWARAMLGWPRISASQ 82
>UniRef50_Q7JMD3 Cluster: Putative uncharacterized protein sir-2.2;
n=4; Caenorhabditis|Rep: Putative uncharacterized
protein sir-2.2 - Caenorhabditis elegans
Length = 289
Score = 91.5 bits (217), Expect = 2e-17
Identities = 51/153 (33%), Positives = 75/153 (49%), Gaps = 3/153 (1%)
Frame = +3
Query: 249 ATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRH 428
A N H + + E + ++TQNVD LH KAGS+ V ELHG++ V+C C Y R
Sbjct: 95 APNINHYALSKWEASDRFQWLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYIESRQ 154
Query: 429 ELQEILTENNPDMESSF---SMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGD 599
Q+ L NP + + PDGD+ K ++ S G +K D+ FFG+
Sbjct: 155 TYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGGLMKTDVTFFGE 214
Query: 600 NVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
NV +V + V D + +G+SL V S +
Sbjct: 215 NVNMDKVNFCYEKVNECDGILSLGTSLAVLSGF 247
Score = 80.6 bits (190), Expect = 3e-14
Identities = 31/52 (59%), Positives = 41/52 (78%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYRS+DVGLYAR HKPI +Q++++ + RQRYW+RN++ WPRF P
Sbjct: 45 GIPDYRSKDVGLYARIAHKPIYFQDYMRSNRCRQRYWSRNFLAWPRFGQAAP 96
>UniRef50_Q8R984 Cluster: NAD-dependent deacetylase 2; n=1;
Thermoanaerobacter tengcongensis|Rep: NAD-dependent
deacetylase 2 - Thermoanaerobacter tengcongensis
Length = 250
Score = 69.7 bits (163), Expect(2) = 3e-16
Identities = 32/92 (34%), Positives = 53/92 (57%), Gaps = 2/92 (2%)
Frame = +3
Query: 228 LAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKC 407
L+ ++ N H + E+EK+G + ++TQN+D LH KAGS+KV E+HG + CL+C
Sbjct: 77 LSSMRNAEPNEAHYILSEMEKEGIIAGVITQNIDNLHQKAGSKKVYEVHGNTREGSCLRC 136
Query: 408 PYEIDRHELQEILTENN--PDMESSFSMIRPD 497
++ L+E + + P + M+RPD
Sbjct: 137 GEKVSFELLEEKVAKEEIPPRCDRCGGMLRPD 168
Score = 38.3 bits (85), Expect(2) = 3e-16
Identities = 19/41 (46%), Positives = 26/41 (63%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
G L+PD+V FGD +P + + K V SD + V+GSSL V
Sbjct: 163 GMLRPDVVLFGDPMP-HAFDLALKEVQESDLLIVIGSSLVV 202
>UniRef50_Q2YZT2 Cluster: Putative uncharacterized protein; n=1;
uncultured delta proteobacterium|Rep: Putative
uncharacterized protein - uncultured delta
proteobacterium
Length = 254
Score = 66.9 bits (156), Expect(2) = 2e-15
Identities = 42/127 (33%), Positives = 62/127 (48%), Gaps = 1/127 (0%)
Frame = +3
Query: 120 GGCWSVCP**SQTYTVSRICEVSESKAKVLGKKLYRLAEI-QLCATNXTHLCIRELEKKG 296
GG WS + + I AKV K L + E+ N H + +LE G
Sbjct: 39 GGLWSRF----DPFEYAHIDAFKRDPAKVW-KMLLEIDEVLNQAKPNRAHYALAKLEAAG 93
Query: 297 KVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESS 476
+ +I+TQN+D +H +AGS+ VIE HG + + C KC + R +EI E+ P +
Sbjct: 94 ILKAIITQNIDNMHQRAGSKNVIEFHGNAETLTCTKCKKKFTR---EEITMESIPPLCEC 150
Query: 477 FSMIRPD 497
+IRPD
Sbjct: 151 KGVIRPD 157
Score = 38.3 bits (85), Expect(2) = 2e-15
Identities = 15/42 (35%), Positives = 24/42 (57%)
Frame = +3
Query: 561 KGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
KG ++PD+VFFG+ +P + K V + V+G+S V
Sbjct: 151 KGVIRPDVVFFGETIPAHATRMAGKEVEKCAMILVIGTSADV 192
>UniRef50_Q6AF12 Cluster: Regulatory protein, Sir2 family; n=2;
Actinobacteria (class)|Rep: Regulatory protein, Sir2
family - Leifsonia xyli subsp. xyli
Length = 283
Score = 84.6 bits (200), Expect = 2e-15
Identities = 53/148 (35%), Positives = 77/148 (52%), Gaps = 2/148 (1%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + LE G +VTQNVD LH KAGS +V++LHG+ V CL C R +
Sbjct: 90 NDGHRALAALEDAGAAAGVVTQNVDGLHKKAGSRRVVDLHGSVDRVLCLVCGQLFAREAI 149
Query: 435 QEILTENNPDMESSFSM-IRPDGDVDCRGNK*KNSELHSAQSVKGP-LKPDIVFFGDNVP 608
+ NP +++ ++ PDGD ++ + +V G LKPD+VFFG+ +P
Sbjct: 150 TAGIDAANPWLDAEGAVEFAPDGDAIVTD---IDAFVIPDCTVCGERLKPDVVFFGEFIP 206
Query: 609 KYRVEQVRKXVTSSDAVFVMGSSLTVYS 692
+ V S+DA+ + GSSL V S
Sbjct: 207 AETYREASALVRSADALVIAGSSLVVNS 234
Score = 45.6 bits (103), Expect = 0.001
Identities = 22/52 (42%), Positives = 34/52 (65%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYR E G R+ P+ +Q+F+ + R+RYWA +++G+ RFS +P
Sbjct: 43 GIPDYRGE--GAPKRT---PMTFQQFLAEDRHRKRYWAGSHLGYRRFSAARP 89
>UniRef50_UPI000050FCF4 Cluster: COG0846: NAD-dependent protein
deacetylases, SIR2 family; n=1; Brevibacterium linens
BL2|Rep: COG0846: NAD-dependent protein deacetylases,
SIR2 family - Brevibacterium linens BL2
Length = 309
Score = 83.0 bits (196), Expect = 6e-15
Identities = 60/191 (31%), Positives = 89/191 (46%), Gaps = 11/191 (5%)
Frame = +3
Query: 153 QTYTVSRICEVSESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDR 332
Q T+ + +A+ + ++ N HL + +L V IVTQNVD
Sbjct: 67 QPMTIQTFLSHPDQRARYWARSWVGWPRMRSARPNAAHLGLAQLP----VAGIVTQNVDG 122
Query: 333 LHHKAGSEK-----VIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSM---- 485
LH A E+ VI+LHG+ V CLK + DR +Q L+E NP+ +
Sbjct: 123 LHQAAAREEGSRSPVIDLHGSLDRVICLKEGHMFDRDWVQIQLSELNPEFAKLVGIDPID 182
Query: 486 --IRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAV 659
PDGDVD + + G LKPD+V+FGD+VP R+++ + + +
Sbjct: 183 VETAPDGDVDLEETA--DFIVTDCPRCGGILKPDVVYFGDSVPPARLQEANRICAEASGI 240
Query: 660 FVMGSSLTVYS 692
V+GSSL V S
Sbjct: 241 VVLGSSLAVLS 251
>UniRef50_A1HLU5 Cluster: Silent information regulator protein Sir2;
n=1; Thermosinus carboxydivorans Nor1|Rep: Silent
information regulator protein Sir2 - Thermosinus
carboxydivorans Nor1
Length = 261
Score = 83.0 bits (196), Expect = 6e-15
Identities = 52/155 (33%), Positives = 78/155 (50%)
Frame = +3
Query: 222 YRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCL 401
+R+A + N HL + EL + G VT +VTQNVD LH +AGS+ V ELHGT V C+
Sbjct: 69 WRIARLWEVQPNPGHLALAELAQAGFVTKLVTQNVDGLHQRAGSQGVAELHGTLRTVSCI 128
Query: 402 KCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPD 581
KC + D + + +N E + G SE + + +G L+PD
Sbjct: 129 KCGSQYDSRQ----MLPHNDTWEEDYK----------AGRYRHGSECYCPR-CQGQLRPD 173
Query: 582 IVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
+V FG+++P + + +D V+GSSL V
Sbjct: 174 VVLFGESLPDTAWNEAVRWSRKADFFVVIGSSLVV 208
>UniRef50_Q974M6 Cluster: NAD-dependent deacetylase; n=8;
Thermoprotei|Rep: NAD-dependent deacetylase - Sulfolobus
tokodaii
Length = 250
Score = 63.7 bits (148), Expect(2) = 1e-14
Identities = 38/84 (45%), Positives = 46/84 (54%), Gaps = 3/84 (3%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGT---SYLVQCLKCPYEIDR 425
N H + ELEK G + +I+TQN+D LH AGS VIELHG Y V CLK Y+ D
Sbjct: 77 NRAHYALAELEKMGLIRAIITQNIDGLHQLAGSRNVIELHGNMRKCYCVNCLK-TYDSDT 135
Query: 426 HELQEILTENNPDMESSFSMIRPD 497
L +I E P +IRPD
Sbjct: 136 -VLDKIDKEGLPPKCECGGVIRPD 158
Score = 38.7 bits (86), Expect(2) = 1e-14
Identities = 17/42 (40%), Positives = 25/42 (59%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
G ++PD+V FG+ P Y + + +D V +GSSLTVY
Sbjct: 153 GVIRPDVVLFGE--PVYNISSALEIAREADLVLAIGSSLTVY 192
>UniRef50_Q55PY8 Cluster: Putative uncharacterized protein; n=2;
Filobasidiella neoformans|Rep: Putative uncharacterized
protein - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 361
Score = 81.0 bits (191), Expect = 3e-14
Identities = 54/170 (31%), Positives = 86/170 (50%), Gaps = 22/170 (12%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKA-------GSEKVIELHGTSYLVQCLKCPY 413
N TH+ I L G +++TQNVD LH KA ++ELHGT V C+K +
Sbjct: 111 NPTHIYIAALLHLGLAPNLITQNVDNLHPKAYRLLSPNTKPPILELHGTLAKVHCMKHRH 170
Query: 414 EIDRHELQEILTENNP-------DMESSFSMIR--PDGDVDCRGNK*KNSELHSAQSVKG 566
E R E QE ++ NP + E + + R PDGDVD RG + S + +
Sbjct: 171 EQSRDEYQEQISRLNPIWDEAAKEAERTGTQPRTNPDGDVDLRGANYNTFNVPSCRICEA 230
Query: 567 P------LKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
+KP++VFFG+ +P ++ + S+ ++ ++G+SL YS++
Sbjct: 231 EGEKPTMVKPNVVFFGETIPPAVRDESFSLINSASSLLILGTSLATYSAF 280
Score = 45.6 bits (103), Expect = 0.001
Identities = 25/63 (39%), Positives = 39/63 (61%), Gaps = 5/63 (7%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVK-YPK---VRQRYWARNYIGWPRFSCVQPT-SH 264
GI YR ++ G Y+ N+KPI + E V+ P+ R+RYWAR+++G+P QP +H
Sbjct: 56 GIRAYRGKE-GSYSNPNYKPILFHELVEDTPRGEMFRRRYWARSFLGYPPVRDAQPNPTH 114
Query: 265 ISV 273
I +
Sbjct: 115 IYI 117
>UniRef50_Q5KZE8 Cluster: NAD-dependent deacetylase 2; n=3;
Bacteria|Rep: NAD-dependent deacetylase 2 - Geobacillus
kaustophilus
Length = 247
Score = 66.9 bits (156), Expect(2) = 4e-14
Identities = 37/95 (38%), Positives = 55/95 (57%)
Frame = +3
Query: 213 KKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLV 392
K+++ L + A N H +R LE+ GK +I+TQN+D LH KAGS VIELHGT +
Sbjct: 68 KRMFSLKMMGGFAPNDGHRFLRWLEEMGKTVTILTQNIDGLHTKAGSTNVIELHGT---L 124
Query: 393 QCLKCPYEIDRHELQEILTENNPDMESSFSMIRPD 497
Q CP ++++L I P E ++++PD
Sbjct: 125 QTATCPSCGNKYDLSFINRHEVPRCEKCQTIVKPD 159
Score = 33.9 bits (74), Expect(2) = 4e-14
Identities = 17/39 (43%), Positives = 24/39 (61%)
Frame = +3
Query: 570 LKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
+KPD+V FG VP R+E+ +SD + MG+SL V
Sbjct: 156 VKPDVVLFGGLVP--RMEEAFAAAAASDLLLAMGTSLEV 192
>UniRef50_A7HL19 Cluster: Silent information regulator protein Sir2;
n=1; Fervidobacterium nodosum Rt17-B1|Rep: Silent
information regulator protein Sir2 - Fervidobacterium
nodosum Rt17-B1
Length = 244
Score = 60.9 bits (141), Expect(2) = 4e-14
Identities = 32/83 (38%), Positives = 45/83 (54%), Gaps = 2/83 (2%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKC--PYEIDRH 428
N H + LEK V ++TQN+D LH KAGS+KV E+HG CLKC Y++
Sbjct: 78 NEIHYLLAYLEKLNIVKGVITQNIDNLHKKAGSQKVAEIHGNVRTWSCLKCGKRYDLFNS 137
Query: 429 ELQEILTENNPDMESSFSMIRPD 497
+ +E L + N E + +PD
Sbjct: 138 QHKEFLIDRNFRCECG-GVTKPD 159
Score = 39.9 bits (89), Expect(2) = 4e-14
Identities = 18/42 (42%), Positives = 22/42 (52%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
G KPDIVFFG+ +P + SD MG+SL VY
Sbjct: 154 GVTKPDIVFFGEMLPLNEYSKAENWAKESDVFIAMGTSLVVY 195
>UniRef50_Q73KE1 Cluster: NAD-dependent deacetylase; n=1; Treponema
denticola|Rep: NAD-dependent deacetylase - Treponema
denticola
Length = 251
Score = 60.1 bits (139), Expect(2) = 5e-14
Identities = 23/50 (46%), Positives = 36/50 (72%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPY 413
H + +LEK+G + +++TQN+D LH KAGS+ VIE+HG+ + C+ C Y
Sbjct: 86 HTVLADLEKRGILKAVITQNIDLLHQKAGSKNVIEVHGSPSVHYCINCSY 135
Score = 40.3 bits (90), Expect(2) = 5e-14
Identities = 18/54 (33%), Positives = 29/54 (53%)
Frame = +3
Query: 528 KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
K E+ P+KP I FFG+ +P+ + + + SD + V+G+SL VY
Sbjct: 147 KTGEVPRCPKCGSPIKPAITFFGEALPQKALMKAETEASKSDFMLVLGTSLLVY 200
>UniRef50_UPI000049979A Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 319
Score = 79.8 bits (188), Expect = 6e-14
Identities = 51/141 (36%), Positives = 73/141 (51%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEI 443
H +R+LE+ GK+ I+TQNVD LH AGS KVIELHGT + QC+KC Y
Sbjct: 95 HFALRKLEEIGKLEEIITQNVDNLHQLAGSRKVIELHGTGKICQCIKCGY---------- 144
Query: 444 LTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVE 623
+ N D ++ P G + ++ G +K D+V FG+ + K + E
Sbjct: 145 --QGNAD------VVLPKGLIPW-------IDIPRCPKCGGLIKLDVVLFGEQLEKEKFE 189
Query: 624 QVRKXVTSSDAVFVMGSSLTV 686
+ + +SSD V+GSSL V
Sbjct: 190 KAFEVASSSDVFLVIGSSLEV 210
>UniRef50_Q2LSF2 Cluster: Sir2 family of NAD+-dependent deacetylase;
n=2; Syntrophus aciditrophicus SB|Rep: Sir2 family of
NAD+-dependent deacetylase - Syntrophus aciditrophicus
(strain SB)
Length = 271
Score = 79.4 bits (187), Expect = 8e-14
Identities = 55/156 (35%), Positives = 78/156 (50%), Gaps = 2/156 (1%)
Frame = +3
Query: 228 LAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGS--EKVIELHGTSYLVQCL 401
LAE Q N HL + ELEK GK+ ++TQN+D LH KAG+ EKV ELHG ++CL
Sbjct: 85 LAEAQ---PNRAHLAVAELEKIGKLNCVITQNIDNLHQKAGNAPEKVYELHGNMRWLKCL 141
Query: 402 KCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPD 581
C DR + E+ E ++ DG C +G +KPD
Sbjct: 142 SCG---DRVSVPEMFRET--------ALQEMDGFPFC-------------AKCQGLMKPD 177
Query: 582 IVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
++FFG+ +P+ + + D + V+GSSL VY
Sbjct: 178 VIFFGEALPEKTLRDATWQARNCDLLLVIGSSLVVY 213
>UniRef50_Q4QB33 Cluster: Sir2-family protein-like protein; n=4;
Trypanosomatidae|Rep: Sir2-family protein-like protein -
Leishmania major
Length = 320
Score = 78.2 bits (184), Expect = 2e-13
Identities = 56/171 (32%), Positives = 72/171 (42%), Gaps = 23/171 (13%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKA------------------GSEKVIELHGT 380
N H+ ++ K G V I+TQNVD LHH A + ELHG
Sbjct: 87 NAAHMALQAFTKSGAVAHILTQNVDGLHHLATYGGVGDAEEEHYYKYTTSDAPLKELHGN 146
Query: 381 SYLVQCLKCPYEIDRHELQEILTENNPDMESSF----SMIRPDGDVDCRGNK*KNSELHS 548
+ V C C + + R LQ L E NP + S RPDGD L
Sbjct: 147 IHNVICTSCGFFMPRARLQRELRERNPGFYEQYGADVSRTRPDGDYSAPTEAVNAMHLVM 206
Query: 549 AQSVKGPLKPDIVFFGDNVPKYRVEQVRKXV-TSSDAVFVMGSSLTVYSSY 698
G KP +V FG+NVPK VE V + + +G+SL VYS+Y
Sbjct: 207 CPRCNGFFKPHVVLFGENVPKPIVEATMSLVRDKASCLLCLGTSLQVYSAY 257
Score = 41.1 bits (92), Expect = 0.025
Identities = 17/44 (38%), Positives = 30/44 (68%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGW 231
GIPDYR + G Y R++ + +Q+F++ ++RYWAR+ +G+
Sbjct: 36 GIPDYRGPN-GQYHRADFVLLTFQKFMRDDNEKRRYWARSMLGY 78
>UniRef50_Q8ZU41 Cluster: NAD-dependent deacetylase 1; n=3;
Pyrobaculum|Rep: NAD-dependent deacetylase 1 -
Pyrobaculum aerophilum
Length = 254
Score = 62.5 bits (145), Expect(2) = 2e-13
Identities = 30/81 (37%), Positives = 42/81 (51%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + E+E+ GK+ +++TQNVDRLH AGS+ VIELHG C C + E
Sbjct: 84 NPAHYALAEMERLGKLCAVITQNVDRLHQAAGSKNVIELHGALEYAVCTNCGSKYALAEA 143
Query: 435 QEILTENNPDMESSFSMIRPD 497
+ P +I+PD
Sbjct: 144 LKWRKSGAPRCPKCGGVIKPD 164
Score = 35.9 bits (79), Expect(2) = 2e-13
Identities = 14/42 (33%), Positives = 25/42 (59%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
G +KPD+VFFG+ +P+ + + ++ +G+SL VY
Sbjct: 159 GVIKPDVVFFGEPLPQDALREAFMLAEMAEVFMAIGTSLAVY 200
>UniRef50_A6DC77 Cluster: Silent information regulator protein Sir2;
n=1; Caminibacter mediatlanticus TB-2|Rep: Silent
information regulator protein Sir2 - Caminibacter
mediatlanticus TB-2
Length = 243
Score = 67.3 bits (157), Expect(2) = 2e-13
Identities = 32/82 (39%), Positives = 50/82 (60%), Gaps = 1/82 (1%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + +LEKKG + +++TQN+D LH KAGS+ VIE HGT+ ++CL C + +
Sbjct: 79 NEAHYFLADLEKKGILKAVITQNIDNLHQKAGSKNVIEFHGTANKLECLNCKSKFNSF-- 136
Query: 435 QEILTENNPDM-ESSFSMIRPD 497
E+ EN P + +++PD
Sbjct: 137 -EVPLENIPPLCPKCNGVLKPD 157
Score = 31.1 bits (67), Expect(2) = 2e-13
Identities = 14/38 (36%), Positives = 23/38 (60%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSS 677
G LKPD VFF + +PK E+ ++D + V+G++
Sbjct: 152 GVLKPDFVFFKEPIPKEAFEKSIYYSQNADIMLVIGTT 189
>UniRef50_Q81NT6 Cluster: NAD-dependent deacetylase; n=11; Bacillus
cereus group|Rep: NAD-dependent deacetylase - Bacillus
anthracis
Length = 242
Score = 62.5 bits (145), Expect(2) = 2e-13
Identities = 33/95 (34%), Positives = 50/95 (52%)
Frame = +3
Query: 213 KKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLV 392
K+++++ N H + ELE++GK +I+TQN+D LH GS+ VI+LHGT
Sbjct: 67 KEIFQINTFHQYKPNRGHRFLAELEEQGKDITILTQNIDGLHQVGGSKHVIDLHGTLQTA 126
Query: 393 QCLKCPYEIDRHELQEILTENNPDMESSFSMIRPD 497
C KC D LQ ++ P E ++ PD
Sbjct: 127 HCPKCKMGYD---LQYMIDHEVPRCEKCNFILNPD 158
Score = 35.9 bits (79), Expect(2) = 2e-13
Identities = 16/39 (41%), Positives = 25/39 (64%)
Frame = +3
Query: 570 LKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
L PD+V +GD +P+Y + K + +D + VMG+SL V
Sbjct: 155 LNPDVVLYGDTLPQY--QNAIKRLYETDVLIVMGTSLKV 191
>UniRef50_A6PTK3 Cluster: Silent information regulator protein Sir2;
n=1; Victivallis vadensis ATCC BAA-548|Rep: Silent
information regulator protein Sir2 - Victivallis
vadensis ATCC BAA-548
Length = 248
Score = 57.6 bits (133), Expect(2) = 2e-13
Identities = 31/93 (33%), Positives = 45/93 (48%)
Frame = +3
Query: 219 LYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQC 398
LYRL E A H + LE+ G + + TQN+D LH +AGS V ELHG+ C
Sbjct: 72 LYRLEEFHPAAV---HRALAGLEQSGLLRGVYTQNIDLLHQQAGSRHVYELHGSPARHHC 128
Query: 399 LKCPYEIDRHELQEILTENNPDMESSFSMIRPD 497
LKC + E+ ++ +++PD
Sbjct: 129 LKCRKQFGYAEIAPLVLAGKVPRCGCGGLVKPD 161
Score = 40.3 bits (90), Expect(2) = 2e-13
Identities = 18/41 (43%), Positives = 28/41 (68%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
G +KPDIVF+G+N+ + + Q + ++ V V+GSSLTV
Sbjct: 156 GLVKPDIVFYGENLDEALLNQAFADMEKAELVLVLGSSLTV 196
>UniRef50_Q12Y78 Cluster: Silent information regulator protein Sir2;
n=1; Methanococcoides burtonii DSM 6242|Rep: Silent
information regulator protein Sir2 - Methanococcoides
burtonii (strain DSM 6242)
Length = 245
Score = 62.1 bits (144), Expect(2) = 3e-13
Identities = 30/79 (37%), Positives = 46/79 (58%), Gaps = 1/79 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEI 443
H + +LE+KG + +I+TQN+D LH KAGS+ VIE+HG+ CL C + + E+
Sbjct: 79 HSVLSKLEEKGIIKAIITQNIDMLHQKAGSKNVIEVHGSPQEHVCLACGKKYSYEYIAEL 138
Query: 444 L-TENNPDMESSFSMIRPD 497
L E P +++PD
Sbjct: 139 LKAEGFPLCNECGGLVKPD 157
Score = 35.5 bits (78), Expect(2) = 3e-13
Identities = 15/41 (36%), Positives = 28/41 (68%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
G +KPDIVF+G+ + + +E+ + + +D + V+GS+L V
Sbjct: 152 GLVKPDIVFYGEMLRQDTIEKAIQESSKADLMLVLGSTLVV 192
>UniRef50_UPI0000D55B5A Cluster: PREDICTED: similar to CG5216-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG5216-PA - Tribolium castaneum
Length = 722
Score = 75.4 bits (177), Expect = 1e-12
Identities = 53/144 (36%), Positives = 72/144 (50%), Gaps = 3/144 (2%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEI 443
H I+ LE GK+ TQN+D L A EKVIE HG+ C KC +++ ++EI
Sbjct: 285 HRFIKMLENYGKLLRNYTQNIDTLEKVANIEKVIECHGSFATATCTKCGHKVTADAIREI 344
Query: 444 -LTENNPDMESSFSMIRPDGDVDCRGNK*KNS-ELHSAQSV-KGPLKPDIVFFGDNVPKY 614
L + P E V C +NS E+ Q V G +KPDIVFFG+ +P
Sbjct: 345 VLAQQIPLCEKCHP---GKTSVPCIEEYKENSEEIDYRQLVSSGIMKPDIVFFGEGLPDT 401
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTV 686
E + + T D + V+GSSL V
Sbjct: 402 FHEAMAQDKTECDLLLVIGSSLKV 425
>UniRef50_A5UYK2 Cluster: Silent information regulator protein Sir2;
n=2; Roseiflexus|Rep: Silent information regulator
protein Sir2 - Roseiflexus sp. RS-1
Length = 261
Score = 58.0 bits (134), Expect(2) = 2e-12
Identities = 30/90 (33%), Positives = 43/90 (47%)
Frame = +3
Query: 228 LAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKC 407
L + A N H + LE+ + +I+TQN D LH +AGS +V ELHG CL+C
Sbjct: 77 LDRVLAAAPNAAHYALAALEQHRTLRAIITQNFDGLHQRAGSREVYELHGHLRTATCLEC 136
Query: 408 PYEIDRHELQEILTENNPDMESSFSMIRPD 497
+I L + P S ++PD
Sbjct: 137 ERQIPTQALLPRIRRGEPPRCSCGHPLKPD 166
Score = 37.1 bits (82), Expect(2) = 2e-12
Identities = 16/41 (39%), Positives = 25/41 (60%)
Frame = +3
Query: 567 PLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
PLKPD+V F + +P+ R+ V +D + V G+SL V+
Sbjct: 162 PLKPDVVLFDEMLPRGLYWLARRAVEHADVIIVAGTSLEVF 202
>UniRef50_Q8U1Q1 Cluster: NAD-dependent deacetylase; n=19; cellular
organisms|Rep: NAD-dependent deacetylase - Pyrococcus
furiosus
Length = 250
Score = 74.5 bits (175), Expect = 2e-12
Identities = 49/156 (31%), Positives = 76/156 (48%)
Frame = +3
Query: 222 YRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCL 401
+R+ +I N H+ + ELEK G + +++TQNVD LH +AGS+ VIELHG + V+C
Sbjct: 66 WRIKKILEAKPNPAHIALAELEKMGIIKAVITQNVDDLHREAGSKNVIELHGNIFRVKCT 125
Query: 402 KCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPD 581
C Y +E L E++ R + EL L+PD
Sbjct: 126 SCSY-------REYLKESD------------------RIGWLLSQELPRCPKCGSLLRPD 160
Query: 582 IVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
+V+FG+ +P+ + +D V V+G+S VY
Sbjct: 161 VVWFGEALPEKELTTAFSLAKKADVVLVVGTSGVVY 196
>UniRef50_Q8ZT00 Cluster: NAD-dependent deacetylase 2; n=2; cellular
organisms|Rep: NAD-dependent deacetylase 2 - Pyrobaculum
aerophilum
Length = 249
Score = 60.5 bits (140), Expect(2) = 3e-12
Identities = 31/78 (39%), Positives = 44/78 (56%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEI 443
H I ELE G V ++TQNVD LH +AGS V+ELHG+ + +C+KC + L +
Sbjct: 78 HYAIAELEAMGVVRGVITQNVDGLHQRAGSRLVVELHGSIWRARCVKCG---SVYILDKP 134
Query: 444 LTENNPDMESSFSMIRPD 497
+ E P ++RPD
Sbjct: 135 VEEVPPLCRKCGGLLRPD 152
Score = 33.9 bits (74), Expect(2) = 3e-12
Identities = 15/42 (35%), Positives = 26/42 (61%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
G L+PD+V+FG+ +P+ + + SD + V+G+S VY
Sbjct: 147 GLLRPDVVWFGEPLPQEAWRAAVELASVSDVLLVVGTSGVVY 188
>UniRef50_A7DQD6 Cluster: Silent information regulator protein Sir2;
n=1; Candidatus Nitrosopumilus maritimus SCM1|Rep:
Silent information regulator protein Sir2 - Candidatus
Nitrosopumilus maritimus SCM1
Length = 242
Score = 63.3 bits (147), Expect(2) = 3e-12
Identities = 36/81 (44%), Positives = 47/81 (58%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H I ELEK V S+ TQN+D LH KAGS KV+ELHG+ ++C C + E+
Sbjct: 79 NQGHKAIAELEKFADVVSL-TQNIDGLHQKAGSTKVLELHGSIVKIKCTVCDFS---DEI 134
Query: 435 QEILTENNPDMESSFSMIRPD 497
TE NP + S++RPD
Sbjct: 135 MTDFTE-NPPLCKCGSILRPD 154
Score = 31.1 bits (67), Expect(2) = 3e-12
Identities = 12/39 (30%), Positives = 25/39 (64%)
Frame = +3
Query: 570 LKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
L+PD+V+FG+++P+ ++ D + ++G+SL V
Sbjct: 151 LRPDVVWFGESLPQDVWQEAIIHANQCDLMIIVGTSLVV 189
>UniRef50_Q9WYW0 Cluster: NAD-dependent deacetylase; n=4;
Thermotoga|Rep: NAD-dependent deacetylase - Thermotoga
maritima
Length = 246
Score = 73.7 bits (173), Expect = 4e-12
Identities = 49/145 (33%), Positives = 83/145 (57%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H+ + +LE+KG + +++TQN+DRLH +AGS+KVIELHG C++C ++ +
Sbjct: 77 NLAHVLLAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCE---KKYTV 133
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
++++ + +ESS P D DC NS + +P+IVFFG+N+P+
Sbjct: 134 EDVIKK----LESSDV---PLCD-DC------NSLI----------RPNIVFFGENLPQD 169
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTVY 689
+ + + + + V+GSSL VY
Sbjct: 170 ALREAIGLSSRASLMIVLGSSLVVY 194
>UniRef50_A4M603 Cluster: Silent information regulator protein Sir2;
n=1; Petrotoga mobilis SJ95|Rep: Silent information
regulator protein Sir2 - Petrotoga mobilis SJ95
Length = 256
Score = 73.3 bits (172), Expect = 5e-12
Identities = 53/142 (37%), Positives = 73/142 (51%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQE 440
TH + +LEK+GK+ IVTQN+D LH KAGS+KV E+HG + C KC ++ +E
Sbjct: 85 THKFLVQLEKEGKLKGIVTQNIDSLHQKAGSKKVYEIHGGCWKNYCTKCKR---KYSQEE 141
Query: 441 ILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRV 620
IL + N N + + G +KPDIVFFG+ V KY
Sbjct: 142 ILEKMN------------------------NEVVPKCDNCGGVIKPDIVFFGEPV-KYLT 176
Query: 621 EQVRKXVTSSDAVFVMGSSLTV 686
E + +S+ V V+GSSL V
Sbjct: 177 ES-EILMKNSELVLVLGSSLAV 197
>UniRef50_A4J646 Cluster: Silent information regulator protein Sir2;
n=2; Peptococcaceae|Rep: Silent information regulator
protein Sir2 - Desulfotomaculum reducens MI-1
Length = 256
Score = 56.8 bits (131), Expect(2) = 3e-11
Identities = 25/64 (39%), Positives = 36/64 (56%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + LEK G + ++TQN+D LH AGS++V E+HG CL C + D +L
Sbjct: 83 NNAHFALARLEKMGWLLGVITQNIDGLHQHAGSKRVWEVHGNLKGCSCLSCKKQFDMGQL 142
Query: 435 QEIL 446
+ L
Sbjct: 143 HKQL 146
Score = 34.3 bits (75), Expect(2) = 3e-11
Identities = 17/42 (40%), Positives = 25/42 (59%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
G L+PD+V FGD +P+ K ++ + V+GSSL VY
Sbjct: 153 GLLRPDVVLFGDAMPE-DFFMAEKVMSGCQLLLVIGSSLQVY 193
>UniRef50_Q97MB4 Cluster: NAD-dependent deacetylase; n=7;
Bacteria|Rep: NAD-dependent deacetylase - Clostridium
acetobutylicum
Length = 245
Score = 58.4 bits (135), Expect(2) = 4e-11
Identities = 28/81 (34%), Positives = 46/81 (56%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + ++E++GK+ +IVTQN+D LH AGS+ V ELHG+ + C+ C D +
Sbjct: 86 NAAHYSLAKIEEQGKLKAIVTQNIDGLHQLAGSKNVYELHGSIHRNYCMDCGKSFDLEYV 145
Query: 435 QEILTENNPDMESSFSMIRPD 497
+ T P + +++PD
Sbjct: 146 IKSET-TIPKCDKCGGIVKPD 165
Score = 31.9 bits (69), Expect(2) = 4e-11
Identities = 13/42 (30%), Positives = 25/42 (59%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
G +KPD+V + + + ++ K ++ +D + V G+SL VY
Sbjct: 160 GIVKPDVVLYEEGLDDSIIQNSVKAISEADTLIVGGTSLVVY 201
>UniRef50_A2QUR5 Cluster: Remark: the H. sapiens SIRT4 belongs to a
group of four human SIRT proteins; n=1; Aspergillus
niger|Rep: Remark: the H. sapiens SIRT4 belongs to a
group of four human SIRT proteins - Aspergillus niger
Length = 357
Score = 70.1 bits (164), Expect = 5e-11
Identities = 52/172 (30%), Positives = 80/172 (46%), Gaps = 24/172 (13%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSE-KVIELHGTSYLVQCLKCPYEIDRHE 431
N TH I+++ KG ++S+VTQNVD H A E +ELHG C+ C ++ R E
Sbjct: 122 NSTHWAIKDIGTKGYISSVVTQNVDSFHSVAHPELPTLELHGYLRSAVCINCRTQVPRDE 181
Query: 432 LQE--------------------ILTENNPDMESSFSM-IRPDGDVDCRGNK*KNSELHS 548
Q+ L +NP+ + + I PDGDVD +
Sbjct: 182 FQQSLERLNPAWAEFLKKMVDIGALNADNPEEQRRRGLKINPDGDVDLPEAPYSTFRYPA 241
Query: 549 A-QSVKGPLKPDIVFFGDNV-PKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
S G LKP ++ FG+N+ P R+ + + + + V+GSSL YS++
Sbjct: 242 CPTSTAGILKPAVIMFGENIDPAVRL-GAEEAIDDAGRLLVLGSSLATYSAW 292
Score = 56.4 bits (130), Expect = 6e-07
Identities = 23/54 (42%), Positives = 32/54 (59%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
G+ DYR E+ ++PI Y EFV + R+RYWAR++IGWP +P S
Sbjct: 70 GLSDYRGENGTYITNKTYRPIYYHEFVARHEFRKRYWARSFIGWPGLLKAKPNS 123
>UniRef50_Q8G465 Cluster: Sir2-type regulatory protein; n=2;
Bifidobacterium longum|Rep: Sir2-type regulatory protein
- Bifidobacterium longum
Length = 216
Score = 68.1 bits (159), Expect = 2e-10
Identities = 45/144 (31%), Positives = 71/144 (49%), Gaps = 2/144 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLKCPYEIDRHELQ 437
H + +LE+ G +T + TQN D LH KAG+ ++ LHGT C+KC E ++
Sbjct: 37 HKALVKLEQAGMLTLLATQNFDALHEKAGNSDNVIVNLHGTIGTSHCMKCHQEYATADIM 96
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYR 617
L E PD ++ GD+ C G +K D+V+FG+ +P
Sbjct: 97 ARLDE-EPD-PHCHRKLKYRGDMPC----------------NGIIKTDVVYFGEALPDGA 138
Query: 618 VEQVRKXVTSSDAVFVMGSSLTVY 689
+E+ T +D ++V+GS+L VY
Sbjct: 139 MEKSYSLATKADELWVIGSTLEVY 162
>UniRef50_Q8CNF4 Cluster: NAD-dependent deacetylase; n=17;
Staphylococcus|Rep: NAD-dependent deacetylase -
Staphylococcus epidermidis (strain ATCC 12228)
Length = 246
Score = 57.2 bits (132), Expect(2) = 2e-10
Identities = 30/81 (37%), Positives = 43/81 (53%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H I +LE + K ++TQN+D LH AGS + ELHGT C+ C YE +
Sbjct: 85 NIVHQWIAQLENQQKSLGVITQNIDGLHEDAGSHNIDELHGTLNRFYCINC-YE--EYSK 141
Query: 435 QEILTENNPDMESSFSMIRPD 497
++T + E ++IRPD
Sbjct: 142 SYVMTHHLKYCEKCGNVIRPD 162
Score = 30.7 bits (66), Expect(2) = 2e-10
Identities = 13/39 (33%), Positives = 24/39 (61%)
Frame = +3
Query: 570 LKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
++PDIV +G+ + + V + + +D + V+GSSL V
Sbjct: 159 IRPDIVLYGEMLNQKTVFKALDKIQHADTLIVLGSSLVV 197
>UniRef50_Q21921 Cluster: NAD-dependent deacetylase SIR2 homolog;
n=2; Caenorhabditis|Rep: NAD-dependent deacetylase SIR2
homolog - Caenorhabditis elegans
Length = 607
Score = 53.6 bits (123), Expect(2) = 3e-10
Identities = 22/60 (36%), Positives = 37/60 (61%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQE 440
+H I+ELE G++ TQN+D L H+ G ++V+E HG+ C +C + D +E++E
Sbjct: 218 SHRFIKELETSGRLLRNYTQNIDTLEHQTGIKRVVECHGSFSKCTCTRCGQKYDGNEIRE 277
Score = 33.9 bits (74), Expect(2) = 3e-10
Identities = 16/42 (38%), Positives = 27/42 (64%)
Frame = +3
Query: 561 KGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
+G +KP+IVFFG+++ + + V + D + V+GSSL V
Sbjct: 291 EGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKV 332
>UniRef50_UPI0000D578DC Cluster: PREDICTED: similar to sirtuin 5
(silent mating type information regulation 2 homolog) 5;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
sirtuin 5 (silent mating type information regulation 2
homolog) 5 - Tribolium castaneum
Length = 254
Score = 66.9 bits (156), Expect = 4e-10
Identities = 51/152 (33%), Positives = 77/152 (50%), Gaps = 7/152 (4%)
Frame = +3
Query: 255 NXTHLCIRELEK----KGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEID 422
N H + + EK +G+ ++TQNVD LH +AGSE V+ELHG+ V C KC
Sbjct: 84 NNAHKALAKYEKICKEQGRQFHVITQNVDGLHKRAGSENVLELHGSLDKVICTKC----- 138
Query: 423 RHELQEILTENNPDMESSFSMIRPDGDVDCRGNK---*KNSELHSAQSVKGPLKPDIVFF 593
+ E+ TE NP E+ +R GD R EL + ++P IV+F
Sbjct: 139 --KQIEVNTE-NPICEA----LRGRGDPSKRDQDLPIIPLEELPKCSECQALVRPYIVWF 191
Query: 594 GDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
G+N+ +++ R+ + S D V+G+S VY
Sbjct: 192 GENLDPDVLDRSRQLIESCDLCLVIGTSSVVY 223
>UniRef50_UPI000049971A Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 285
Score = 66.5 bits (155), Expect = 6e-10
Identities = 46/144 (31%), Positives = 71/144 (49%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + ELEK G V +IVTQNVD LH +AGS+ V+E+HG+ C+ C Y
Sbjct: 98 NHVHEALAELEKIGVVKTIVTQNVDGLHQQAGSKNVVEMHGSGRACYCIDCDY------- 150
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
++ + D+ S +P C + G LK D+V FG+ + +
Sbjct: 151 ---ISRADDDIWS-----KPVPPSQC---------IPRCPKCGGLLKLDVVLFGEKLDRV 193
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTV 686
++V + T +D + V+G+SL V
Sbjct: 194 TYDEVVEASTKTDFLLVIGTSLQV 217
>UniRef50_A1A3R7 Cluster: Sir2-type regulatory protein; n=2;
Bifidobacterium adolescentis|Rep: Sir2-type regulatory
protein - Bifidobacterium adolescentis (strain ATCC
15703 / DSM 20083)
Length = 218
Score = 66.1 bits (154), Expect = 8e-10
Identities = 44/143 (30%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H + +LE+ G +T + TQN D LH KAG S ++ LHGT C+KC + D E+
Sbjct: 37 HKALVKLEQAGLLTLLATQNFDALHEKAGNSSNVIVNLHGTIGTSHCMKCHAKYDTAEIM 96
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYR 617
L +N PD + G++ C G +K D+V+FG+ +P
Sbjct: 97 ANL-DNEPD-PHCHRKLPYSGNMPC----------------DGLIKTDVVYFGEALPDGA 138
Query: 618 VEQVRKXVTSSDAVFVMGSSLTV 686
+E+ + +D ++V+GS+L V
Sbjct: 139 IEKSYRLAAQADELWVIGSTLEV 161
>UniRef50_Q5YR82 Cluster: Putative Sir2 family regulator; n=1;
Nocardia farcinica|Rep: Putative Sir2 family regulator -
Nocardia farcinica
Length = 248
Score = 65.7 bits (153), Expect = 1e-09
Identities = 29/72 (40%), Positives = 45/72 (62%), Gaps = 2/72 (2%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGS--EKVIELHGTSYLVQCLKCPYEIDRH 428
N HL + +LE+ G+ +I+TQNVDRLH +AGS ++V+E+HG + V C+ C YE
Sbjct: 76 NAGHLALVDLERAGRAVTIITQNVDRLHQRAGSSPQRVVEIHGNMFEVVCVGCDYETGMA 135
Query: 429 ELQEILTENNPD 464
++ + PD
Sbjct: 136 DVLARVEAGEPD 147
>UniRef50_O94640 Cluster: NAD-dependent histone deacetylase sir2;
n=1; Schizosaccharomyces pombe|Rep: NAD-dependent
histone deacetylase sir2 - Schizosaccharomyces pombe
(Fission yeast)
Length = 475
Score = 65.7 bits (153), Expect = 1e-09
Identities = 44/152 (28%), Positives = 75/152 (49%), Gaps = 10/152 (6%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
+H IR LEKK K++++ TQN+D L K G K+I+ HG+ C+KC +++D EL
Sbjct: 227 SHAFIRLLEKKNKLSTLFTQNIDNLEKKTGLSDNKIIQCHGSFATATCIKCKHKVDGSEL 286
Query: 435 QEILTENNPDMESSFS----MIRPDGDVDCRGNK*KNSELHSAQ---SVKGPLKPDIVFF 593
E + + +R G + + + S++ + G +KPDI FF
Sbjct: 287 YEDIRNQRVSYCNECGKPPLKLRRVGQNKKEKHYFSDGDSESSEDDLAQPGIMKPDITFF 346
Query: 594 GDNVPKYRVEQVRK-XVTSSDAVFVMGSSLTV 686
G+ +P +V + +D + +G+SL V
Sbjct: 347 GEALPDSFFNKVGSGELEETDLLICIGTSLKV 378
>UniRef50_O07595 Cluster: NAD-dependent deacetylase; n=3;
Bacillus|Rep: NAD-dependent deacetylase - Bacillus
subtilis
Length = 247
Score = 65.7 bits (153), Expect = 1e-09
Identities = 52/158 (32%), Positives = 80/158 (50%)
Frame = +3
Query: 213 KKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLV 392
K+L+++ N HL + ELEK+GK I TQN+D LH KAGS V ELHG+ +
Sbjct: 65 KELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNIDGLHKKAGSRHVYELHGS---I 121
Query: 393 QCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPL 572
Q CP R++L +L P+ ++ + +GD+ C G L
Sbjct: 122 QTAACPACGARYDLPHLLEREVPECTAAGN----NGDI-C-GT---------------VL 160
Query: 573 KPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
K D+V FGD V + + + + + +D + V+G+SL V
Sbjct: 161 KTDVVLFGDAVMHF--DTLYEKLDQADLLLVIGTSLEV 196
>UniRef50_A1I9S7 Cluster: NAD-dependent deacetylase; n=1; Candidatus
Desulfococcus oleovorans Hxd3|Rep: NAD-dependent
deacetylase - Candidatus Desulfococcus oleovorans Hxd3
Length = 273
Score = 64.9 bits (151), Expect = 2e-09
Identities = 52/192 (27%), Positives = 84/192 (43%), Gaps = 6/192 (3%)
Frame = +3
Query: 120 GGCWSVCP**SQTYTVSRICEVSESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKKGK 299
GG W T + + ++ K++ + LA N H + +LE+ G
Sbjct: 41 GGVWDRLNPAEVGDTQGLLASLEKNPEKLVAMFMELLAVFDAAIPNPGHRALFDLERMGI 100
Query: 300 VTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKC--PYEIDRHELQEILTE---NNPD 464
+ +++TQN+D LH +AG+ +VIE+HG + +CLKC +RH L + E PD
Sbjct: 101 LQAVITQNIDNLHQEAGNTQVIEMHGNGFRFRCLKCRSRRSHERHALIGRVKERLSTLPD 160
Query: 465 ME-SSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXV 641
+S PD D+ G ++PD+V FG+ V VE
Sbjct: 161 FSPASIFAAMPDCDLCGSG-----------------MRPDVVMFGETV--MEVENAFAAA 201
Query: 642 TSSDAVFVMGSS 677
S D + +G+S
Sbjct: 202 RSCDVMLALGTS 213
>UniRef50_O96505 Cluster: SIR2; n=4; Sophophora|Rep: SIR2 -
Drosophila melanogaster (Fruit fly)
Length = 823
Score = 64.9 bits (151), Expect = 2e-09
Identities = 44/142 (30%), Positives = 66/142 (46%), Gaps = 1/142 (0%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQ-E 440
H I+ LE KGK+ TQN+D L AG ++VIE HG+ C KC ++ + L+ +
Sbjct: 295 HRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVIECHGSFSTASCTKCRFKCNADALRAD 354
Query: 441 ILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRV 620
I + P +P+ + + E G +KPDIVFFG+ +P
Sbjct: 355 IFAQRIP----VCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYH 410
Query: 621 EQVRKXVTSSDAVFVMGSSLTV 686
+ D + V+GSSL V
Sbjct: 411 TVMATDKDVCDLLIVIGSSLKV 432
>UniRef50_A5K7T7 Cluster: NAD-dependent deacetylase, putative; n=5;
Plasmodium|Rep: NAD-dependent deacetylase, putative -
Plasmodium vivax
Length = 306
Score = 64.9 bits (151), Expect = 2e-09
Identities = 42/144 (29%), Positives = 73/144 (50%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + +LE G + +++TQN+D LH ++G+ KVI LHG+ + +C C I +L
Sbjct: 93 NPGHTALSKLESLGYLKTVITQNIDGLHEESGNSKVIPLHGSVFEARCCTCRETI---QL 149
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
+I+ + ++S M + + C G KP++V FG+ +PK
Sbjct: 150 NKIMLQ-----KTSHFMHQLPPECPC----------------GGIFKPNVVLFGEVIPKS 188
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTV 686
++Q K + D + V+G+S TV
Sbjct: 189 LLKQAEKEIDKCDLLLVIGTSSTV 212
>UniRef50_A2Q9C4 Cluster: Contig An01c0250, complete genome; n=18;
Pezizomycotina|Rep: Contig An01c0250, complete genome -
Aspergillus niger
Length = 495
Score = 64.5 bits (150), Expect = 2e-09
Identities = 47/157 (29%), Positives = 75/157 (47%), Gaps = 15/157 (9%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH IR L+ KGK+ + TQN+D + AG E +++ HG+ C+KC Y++ E+
Sbjct: 250 THAFIRVLQDKGKLLTNYTQNIDNIEANAGVLPENIVQCHGSFATATCVKCQYKVKGDEI 309
Query: 435 -QEILTENNPDMESSFSMIRPDGDVDCRGNK---*KNSELHSAQS--------VKGPLKP 578
EI P +S I D + + + KN + + S G +KP
Sbjct: 310 FDEIKKGVIPQCDSCRKRIAEDSGIKRKRSSNGVHKNRKDNDGDSTDDDYEIPTPGVMKP 369
Query: 579 DIVFFGDNVP-KYRVEQVRKXVTSSDAVFVMGSSLTV 686
DI FFG+++P ++ + D V V+G+SL V
Sbjct: 370 DITFFGEDLPDEFGRRLLHHDRDQVDLVIVIGTSLKV 406
Score = 33.5 bits (73), Expect = 5.1
Identities = 13/20 (65%), Positives = 17/20 (85%)
Frame = +1
Query: 94 SLGIPDYRSEDVGLYARSNH 153
SLGIPD+RS+D GLY++ H
Sbjct: 192 SLGIPDFRSKDTGLYSQLAH 211
>UniRef50_Q5L014 Cluster: NAD-dependent deacetylase 1; n=7;
Bacillaceae|Rep: NAD-dependent deacetylase 1 -
Geobacillus kaustophilus
Length = 242
Score = 64.5 bits (150), Expect = 2e-09
Identities = 28/62 (45%), Positives = 40/62 (64%)
Frame = +3
Query: 222 YRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCL 401
YR+ +Q C + H + + E++G V +IVTQNVD H +AGS +VIELHG+ V C
Sbjct: 65 YRIRTLQQCQPHDGHRLLADWERRGIVQTIVTQNVDGFHQEAGSRRVIELHGSLRTVHCQ 124
Query: 402 KC 407
+C
Sbjct: 125 RC 126
Score = 33.9 bits (74), Expect = 3.9
Identities = 14/41 (34%), Positives = 24/41 (58%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
G L+P +V FG+ +P+ + + + +D V+GSSL V
Sbjct: 146 GVLRPSVVLFGEPLPEKAITEAWEAAQQADLFLVLGSSLQV 186
>UniRef50_Q3A6W7 Cluster: NAD-dependent protein deacetylases, SIR2
family; n=2; Pelobacter|Rep: NAD-dependent protein
deacetylases, SIR2 family - Pelobacter carbinolicus
(strain DSM 2380 / Gra Bd 1)
Length = 278
Score = 63.7 bits (148), Expect = 4e-09
Identities = 49/142 (34%), Positives = 66/142 (46%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQE 440
TH + LEK G + ++TQN+D LH AGS KVI+LHG+ QCL C + E
Sbjct: 101 THRFLAGLEKAGGLAGLITQNIDMLHQLAGSRKVIDLHGSYRSAQCLFC------GKSYE 154
Query: 441 ILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRV 620
L+ + S S P L + LKPDIVFFG+ V +
Sbjct: 155 ALSYTWWERAMSTSSKPP---------------LAYCSACNSVLKPDIVFFGEMV--HAF 197
Query: 621 EQVRKXVTSSDAVFVMGSSLTV 686
E + + D + V+GSSL V
Sbjct: 198 EAAEQLIAQCDLLLVLGSSLKV 219
>UniRef50_UPI00015B57C0 Cluster: PREDICTED: similar to GA18743-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
GA18743-PA - Nasonia vitripennis
Length = 871
Score = 63.3 bits (147), Expect = 6e-09
Identities = 42/142 (29%), Positives = 66/142 (46%), Gaps = 1/142 (0%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQ-E 440
H I+ LEK+ K+ +QN+D L AG +IE HG+ C KC Y++ +++ E
Sbjct: 278 HQFIKMLEKQKKLLRNYSQNIDTLERVAGINNLIECHGSFATASCTKCKYQVKSDDVKAE 337
Query: 441 ILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRV 620
I + P P +S+ + +G +KPDIVFFG+ +P
Sbjct: 338 IFAQTIPMCPKCQEQSLPS------ITDPTSSDNYRDIVAQGVMKPDIVFFGEGLPDAFH 391
Query: 621 EQVRKXVTSSDAVFVMGSSLTV 686
+ + D + V+GSSL V
Sbjct: 392 DAMASDKDVCDLLIVIGSSLKV 413
>UniRef50_Q54GV7 Cluster: NAD(+)-dependent deacetylase, silent
information regulator protein (Sir2) family protein;
n=1; Dictyostelium discoideum AX4|Rep: NAD(+)-dependent
deacetylase, silent information regulator protein (Sir2)
family protein - Dictyostelium discoideum AX4
Length = 542
Score = 62.9 bits (146), Expect = 7e-09
Identities = 48/144 (33%), Positives = 71/144 (49%), Gaps = 2/144 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH I+ L++KGK+ TQN+D L H AG EK++ HG+ C+ C +D +
Sbjct: 372 THSFIKLLDEKGKLLRNYTQNIDTLEHVAGIDREKLVNCHGSFSTATCITCKLTVDGTTI 431
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
++ + + ME C+ + + QS +KPDIVFFG+N+P
Sbjct: 432 RDTIMK----MEIPL----------CQ-------QCNDGQSF---MKPDIVFFGENLPDR 467
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTV 686
+ V K V D + VMGSSL V
Sbjct: 468 FDQCVLKDVKDIDLLIVMGSSLQV 491
>UniRef50_Q9NXA8 Cluster: NAD-dependent deacetylase sirtuin-5; n=28;
Coelomata|Rep: NAD-dependent deacetylase sirtuin-5 -
Homo sapiens (Human)
Length = 310
Score = 62.9 bits (146), Expect = 7e-09
Identities = 39/141 (27%), Positives = 69/141 (48%), Gaps = 1/141 (0%)
Frame = +3
Query: 270 CIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILT 449
C L K+G+ ++TQN+D LH KAG++ ++E+HG+ + +C C + ++
Sbjct: 124 CETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYK------ 177
Query: 450 ENNPDMESSFSMIRPD-GDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQ 626
+P + P+ G D K A G L+P +V+FG+N+ +E+
Sbjct: 178 --SPICPALSGKGAPEPGTQDASIPVEKLPRCEEA-GCGGLLRPHVVWFGENLDPAILEE 234
Query: 627 VRKXVTSSDAVFVMGSSLTVY 689
V + + D V+G+S VY
Sbjct: 235 VDRELAHCDLCLVVGTSSVVY 255
>UniRef50_UPI00006CB0CC Cluster: transcriptional regulator, Sir2
family protein; n=1; Tetrahymena thermophila SB210|Rep:
transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 442
Score = 62.5 bits (145), Expect = 1e-08
Identities = 51/175 (29%), Positives = 87/175 (49%), Gaps = 3/175 (1%)
Frame = +3
Query: 180 EVSESKAKVLGKKLYRLAEIQLCA-TNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG-- 350
E+ E+K K L +K + + A + TH+ I +L K+ + S++TQNVD LHH++G
Sbjct: 104 ELEENKKKFLEEKGKPQIILAINAFPSPTHMAISKLYKENLIKSVITQNVDNLHHQSGIP 163
Query: 351 SEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*K 530
+ + ELHG +C KC Y R + D ++ + + +G C G
Sbjct: 164 RKDIHELHGNIISERCEKCNYVHYRDFYTRLKHLKWGDPHNTGRICQKNG---CDG---- 216
Query: 531 NSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSS 695
+LH +VFFG++V + + ++ + S+D V+G+SLTV S+
Sbjct: 217 --QLHDT----------LVFFGESVLQNIKQSAQEQIESADLCIVVGTSLTVQSA 259
>UniRef50_Q5V4Q5 Cluster: NAD-dependent deacetylase; n=2;
Halobacteriaceae|Rep: NAD-dependent deacetylase -
Haloarcula marismortui (Halobacterium marismortui)
Length = 260
Score = 61.7 bits (143), Expect = 2e-08
Identities = 43/144 (29%), Positives = 67/144 (46%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + LE G + +++TQN+D LH AG+++V+ELHGT V C C + D +
Sbjct: 93 NAAHEALAALEADGHLDAVLTQNIDGLHDAAGTDRVVELHGTHRRVVCDDCGHRRDAEVV 152
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
E E+ S + P DC G +PD+V FG+ +P
Sbjct: 153 FEQAAES--------SDLPP--RCDCGG----------------VYRPDVVLFGEPMPDV 186
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTV 686
+ + ++ SD +GSSL+V
Sbjct: 187 AMNEAQRLARDSDVFLAVGSSLSV 210
>UniRef50_A6P1S7 Cluster: Putative uncharacterized protein; n=2;
Bacteria|Rep: Putative uncharacterized protein -
Bacteroides capillosus ATCC 29799
Length = 262
Score = 61.3 bits (142), Expect = 2e-08
Identities = 27/51 (52%), Positives = 36/51 (70%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKC 407
N H + ELE+ GK+T++VTQN+D LH KAGS+ V+ELHG+ C KC
Sbjct: 102 NAAHKKLAELEQAGKLTAMVTQNIDGLHQKAGSKNVLELHGSVLRNYCEKC 152
>UniRef50_A0LG97 Cluster: Silent information regulator protein Sir2;
n=1; Syntrophobacter fumaroxidans MPOB|Rep: Silent
information regulator protein Sir2 - Syntrophobacter
fumaroxidans (strain DSM 10017 / MPOB)
Length = 248
Score = 61.3 bits (142), Expect = 2e-08
Identities = 26/59 (44%), Positives = 39/59 (66%)
Frame = +3
Query: 231 AEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKC 407
A ++ N HL + +LEK+G V +VTQN+D LH +AGS+ VIE HG + ++C +C
Sbjct: 71 AVLRQARPNFAHLALADLEKRGIVKELVTQNIDSLHQRAGSKNVIEFHGHNRSLRCDRC 129
>UniRef50_Q1RPU3 Cluster: Zinc finger protein; n=1; Ciona
intestinalis|Rep: Zinc finger protein - Ciona
intestinalis (Transparent sea squirt)
Length = 737
Score = 60.9 bits (141), Expect = 3e-08
Identities = 44/141 (31%), Positives = 64/141 (45%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEI 443
H I LEK G++ TQN+D L AG KV++ HG+ C C Y+ + EL+
Sbjct: 262 HRFISLLEKTGRLLRNYTQNIDTLEQVAGISKVVQCHGSFATASCCSCDYKTNCEELRAD 321
Query: 444 LTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVE 623
+ F+ + P C G +KPDIVFFG+N+P+
Sbjct: 322 I----------FNQVVP----HCP---------RCPSDDPGVIKPDIVFFGENLPQQFHR 358
Query: 624 QVRKXVTSSDAVFVMGSSLTV 686
Q+ +D + V+GSSL V
Sbjct: 359 QMTSDKDDADLLIVIGSSLKV 379
>UniRef50_Q2U9Y7 Cluster: Sirtuin 4 and related class II sirtuins;
n=10; Pezizomycotina|Rep: Sirtuin 4 and related class II
sirtuins - Aspergillus oryzae
Length = 407
Score = 60.5 bits (140), Expect = 4e-08
Identities = 32/70 (45%), Positives = 41/70 (58%), Gaps = 1/70 (1%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSE-KVIELHGTSYLVQCLKCPYEIDRHE 431
N TH IR+L KG ++S+VTQNVD H A S+ IELHG V C+ C + R E
Sbjct: 149 NSTHWAIRDLGAKGYLSSVVTQNVDSFHPIAHSKLSTIELHGYLRSVVCISCQNQFPRDE 208
Query: 432 LQEILTENNP 461
Q+ L + NP
Sbjct: 209 FQKSLEKLNP 218
Score = 55.6 bits (128), Expect = 1e-06
Identities = 21/54 (38%), Positives = 33/54 (61%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
G+ DYR E+ ++PI + EF+K + R+RYWAR+++GWP +P S
Sbjct: 97 GLSDYRGENGTYVTNKTYRPIYFHEFLKRHEFRKRYWARSFVGWPGLVKAKPNS 150
Score = 33.9 bits (74), Expect = 3.9
Identities = 13/48 (27%), Positives = 26/48 (54%)
Frame = +3
Query: 555 SVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
S G LKP ++ FG+N+ + + + + ++GSSL +S++
Sbjct: 299 STAGVLKPAVIMFGENIQPAVKTAAEEAIDDAGRLLILGSSLATFSAW 346
>UniRef50_Q3F1F4 Cluster: SIR2 family protein; n=1; Bacillus
thuringiensis serovar israelensis ATCC 35646|Rep: SIR2
family protein - Bacillus thuringiensis serovar
israelensis ATCC 35646
Length = 241
Score = 59.7 bits (138), Expect = 7e-08
Identities = 27/66 (40%), Positives = 39/66 (59%)
Frame = +3
Query: 225 RLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLK 404
R+ +I C N H + + E++GKV S++TQN+D H AGS+ VIE+HG + C
Sbjct: 65 RMNDISNCKPNKAHEILAKWEEQGKVKSVITQNIDSYHKDAGSKNVIEMHGHLRNLVCDT 124
Query: 405 CPYEID 422
C E D
Sbjct: 125 CSKEYD 130
Score = 36.7 bits (81), Expect = 0.55
Identities = 14/42 (33%), Positives = 26/42 (61%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
G ++P++V FG+ +P Q + + +D V V+G+SL V+
Sbjct: 150 GVVRPEVVLFGETLPPLAWHQANEQMKKTDLVIVLGTSLQVF 191
>UniRef50_A1FG80 Cluster: Silent information regulator protein Sir2;
n=3; Pseudomonas|Rep: Silent information regulator
protein Sir2 - Pseudomonas putida W619
Length = 252
Score = 59.3 bits (137), Expect = 9e-08
Identities = 26/73 (35%), Positives = 41/73 (56%)
Frame = +3
Query: 189 ESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIE 368
E+ A V G L+R ++ N H I L G+ ++VTQN+D LH +AG+++V+
Sbjct: 58 ENPALVWGWYLWRRQQVMQAKPNAAHQAIHRLSGSGRSVTVVTQNIDDLHERAGNQEVLH 117
Query: 369 LHGTSYLVQCLKC 407
LHG+ +C C
Sbjct: 118 LHGSLMRPKCFAC 130
>UniRef50_Q4WET3 Cluster: SIR2 family histone deacetylase, putative;
n=4; Pezizomycotina|Rep: SIR2 family histone
deacetylase, putative - Aspergillus fumigatus (Sartorya
fumigata)
Length = 381
Score = 59.3 bits (137), Expect = 9e-08
Identities = 33/70 (47%), Positives = 38/70 (54%), Gaps = 1/70 (1%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSE-KVIELHGTSYLVQCLKCPYEIDRHE 431
N TH IR+L KG V+S+VTQNVD H A E IELHG V C C + R E
Sbjct: 122 NSTHWAIRDLAAKGFVSSVVTQNVDSFHSIAHPELPTIELHGHLKSVVCTSCRNQFSRAE 181
Query: 432 LQEILTENNP 461
Q+ L NP
Sbjct: 182 FQKSLERLNP 191
Score = 51.6 bits (118), Expect = 2e-05
Identities = 20/54 (37%), Positives = 31/54 (57%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
G+ DYR E ++PI + EF+ + R+RYWAR+++GWP +P S
Sbjct: 70 GLSDYRGEKGTYVTNKFYRPIYFHEFLSRHESRKRYWARSFVGWPGLLKAEPNS 123
Score = 35.1 bits (77), Expect = 1.7
Identities = 15/48 (31%), Positives = 26/48 (54%)
Frame = +3
Query: 555 SVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
S G LKP +V FG+N+ + + + + ++GSSL YS++
Sbjct: 272 STAGILKPAVVMFGENIDPGVKTAAEEAIDDAGRLLILGSSLATYSAW 319
>UniRef50_Q8F3Z6 Cluster: NAD-dependent deacetylase; n=4;
Leptospira|Rep: NAD-dependent deacetylase - Leptospira
interrogans
Length = 246
Score = 59.3 bits (137), Expect = 9e-08
Identities = 31/92 (33%), Positives = 50/92 (54%)
Frame = +3
Query: 219 LYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQC 398
L+R I+ N H + ELE+ ++TQNVD LH +AGS+K+ E+HG ++ +C
Sbjct: 65 LWRRNIIETKRPNPGHFALVELERIHPDFFLITQNVDGLHSQAGSKKLTEIHGNIFINRC 124
Query: 399 LKCPYEIDRHELQEILTENNPDMESSFSMIRP 494
+ C E + + E T P ++ S +RP
Sbjct: 125 ISCGQE-SKETISENTTPLPPQCQNCNSFLRP 155
>UniRef50_A7RLD5 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 335
Score = 58.8 bits (136), Expect = 1e-07
Identities = 46/147 (31%), Positives = 69/147 (46%), Gaps = 3/147 (2%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRH 428
N H ++ L KG + + TQN+D L AG +EK++E HGT C+ C + D
Sbjct: 65 NYVHYFVKLLHDKGFLLRMYTQNIDGLERLAGLPAEKLVEAHGTFSTASCISCHHSYDGE 124
Query: 429 ELQEILTENNPDMESSFSMIRPDGDVD-CRGNK*KNSELHSAQSVKGPLKPDIVFFGDNV 605
++++ + EN GD+ C K KG +KPD+VFFG+++
Sbjct: 125 QIRKTI-EN--------------GDIPRCETIK-----------CKGVIKPDVVFFGEDL 158
Query: 606 PKYRVEQVRKXVTSSDAVFVMGSSLTV 686
PK R D + VMG+SL V
Sbjct: 159 PK-RFYSFEIDFRKCDLLLVMGTSLEV 184
>UniRef50_Q899G3 Cluster: NAD-dependent deacetylase; n=19; cellular
organisms|Rep: NAD-dependent deacetylase - Clostridium
tetani
Length = 247
Score = 58.4 bits (135), Expect = 2e-07
Identities = 49/145 (33%), Positives = 69/145 (47%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + +LEK GK+ +I+TQN+D LH AGS+ VIELHG C+ C D L
Sbjct: 83 NLAHHALAKLEKVGKLKAIITQNIDGLHQLAGSKNVIELHGGVGRNYCMDCNKFFD---L 139
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
IL NN + + P DV C G +KPD+V + + +
Sbjct: 140 NYIL--NNKE-------VVPKCDV-C----------------GGIVKPDVVLYEEPLNMD 173
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTVY 689
+ + V +SD + V G+SL VY
Sbjct: 174 NINNAVRYVENSDVLIVGGTSLVVY 198
>UniRef50_Q07FY7 Cluster: Sirtuin (Silent mating type information
regulation 2 homolog) 3; n=3; Xenopus|Rep: Sirtuin
(Silent mating type information regulation 2 homolog) 3
- Xenopus tropicalis (Western clawed frog) (Silurana
tropicalis)
Length = 401
Score = 58.0 bits (134), Expect = 2e-07
Identities = 43/146 (29%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGS--EKVIELHGTSYLVQCLKCPYEIDRH 428
N H I+ L KG + TQN+D L AG EK++E+HGT + C C +
Sbjct: 196 NLVHYFIKLLHDKGLLLRCYTQNIDGLERLAGIPVEKIVEVHGTFFSASCSLCYTPFPAN 255
Query: 429 ELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
E +E++ DG+ C + GP+KPDIVFFG+++P
Sbjct: 256 EAKELIF---------------DGNPPC------------CKFCAGPVKPDIVFFGEDLP 288
Query: 609 KYRVEQVRKXVTSSDAVFVMGSSLTV 686
+ Q + +D + +MG+SL +
Sbjct: 289 Q-TFTQAYQDFPKADLLIIMGTSLKI 313
>UniRef50_Q4P1X1 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 434
Score = 58.0 bits (134), Expect = 2e-07
Identities = 45/143 (31%), Positives = 70/143 (48%), Gaps = 2/143 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSE--KVIELHGTSYLVQCLKCPYEIDRHELQ 437
H + L++K K+ + TQNVD L AG E KV+E HG+ C+ C + +D ++
Sbjct: 123 HYFLTLLQRKQKLKRVFTQNVDTLERIAGVEADKVVEAHGSFATSTCIVCKHSVDDDWIR 182
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYR 617
N + RP C G K + + G +KPDIVFFG+++P R
Sbjct: 183 -----NKVESGQVARCPRPK----CPGRKTGSK----GEQRGGLVKPDIVFFGESLPP-R 228
Query: 618 VEQVRKXVTSSDAVFVMGSSLTV 686
+ + ++D + VMG+SL V
Sbjct: 229 FFRCIPDLKTADLLIVMGTSLQV 251
>UniRef50_A1DG07 Cluster: SIR2 family histone deacetylase, putative;
n=3; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Neosartorya fischeri (strain
ATCC 1020 / DSM 3700 / NRRL 181)(Aspergillus
fischerianus (strain ATCC 1020 / DSM 3700 / NRRL 181))
Length = 425
Score = 40.7 bits (91), Expect(2) = 3e-07
Identities = 22/81 (27%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H ++ L KG + TQN+D L AG EK++E HG+ C+ C +++
Sbjct: 108 HSFVKLLHDKGLLLKHFTQNIDCLERLAGVPGEKIVEAHGSFASQHCIDCKAAYPEPQMK 167
Query: 438 EILTENN-PDMESSFSMIRPD 497
E + + P ++PD
Sbjct: 168 EAIAKGEVPHCPHCNGFVKPD 188
Score = 36.7 bits (81), Expect(2) = 3e-07
Identities = 19/42 (45%), Positives = 26/42 (61%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
G +KPDIVFFG+ +P+ R +D VMG+SLTV+
Sbjct: 183 GFVKPDIVFFGEALPE-EFHANRSLPEQADLCIVMGTSLTVH 223
>UniRef50_Q011Q8 Cluster: NAD-dependent deacetylase SIRT2; n=2;
Ostreococcus|Rep: NAD-dependent deacetylase SIRT2 -
Ostreococcus tauri
Length = 394
Score = 39.1 bits (87), Expect(2) = 3e-07
Identities = 17/40 (42%), Positives = 27/40 (67%)
Frame = +3
Query: 570 LKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
+KPDIVFFG+N+P+ E ++ D + V+G+SL V+
Sbjct: 251 VKPDIVFFGENLPRRFFECAQEDFEVCDLLIVIGTSLVVH 290
Score = 38.3 bits (85), Expect(2) = 3e-07
Identities = 27/86 (31%), Positives = 38/86 (44%), Gaps = 3/86 (3%)
Frame = +3
Query: 249 ATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEID 422
A TH I+ L KG + TQN+D L G EKV+ HG CL+ +E D
Sbjct: 170 APTPTHYFIKLLHDKGILRRCFTQNIDSLERATGLPKEKVVPAHGNFDGAHCLR-GHEAD 228
Query: 423 RHELQEILTENNPDMESSF-SMIRPD 497
E+ + P + S ++PD
Sbjct: 229 VDEVADACRAGTPMICSKCGEYVKPD 254
>UniRef50_A7RMK8 Cluster: Predicted protein; n=5; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 273
Score = 57.6 bits (133), Expect = 3e-07
Identities = 46/162 (28%), Positives = 74/162 (45%), Gaps = 6/162 (3%)
Frame = +3
Query: 222 YRLAEIQLCATNXTHLCIRELEKK----GKVTSIVTQNVDRLHHKAGSEKVIELHGTSYL 389
YR + N H I E +KK GK +VTQN+D LH AG+E VIELHGT +
Sbjct: 79 YRREVVLSKKPNPAHFAIAEFQKKMRNEGKQVWVVTQNIDELHKTAGAEDVIELHGTLFK 138
Query: 390 VQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSA--QSVK 563
+C + T+ + + ++ PD + K +EL
Sbjct: 139 TRC------------NHVTTQGSITLG---IVLAPDPNAP--DAKIPLTELPRCVRPECD 181
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
++P +V+FG+ + ++Q+ K + D F++G+S VY
Sbjct: 182 ALVRPHVVWFGEALDPVVLQQIEKVLGECDFCFIVGTSSVVY 223
>UniRef50_A6LP94 Cluster: Silent information regulator protein Sir2;
n=1; Thermosipho melanesiensis BI429|Rep: Silent
information regulator protein Sir2 - Thermosipho
melanesiensis BI429
Length = 234
Score = 57.2 bits (132), Expect = 4e-07
Identities = 24/51 (47%), Positives = 34/51 (66%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKC 407
N +H + ELE+ G + ++TQN+D LH+KAGS VIELHG + C +C
Sbjct: 75 NMSHKLLAELEEMGYLLGVITQNIDDLHNKAGSRNVIELHGNATHFYCEEC 125
Score = 37.1 bits (82), Expect = 0.41
Identities = 18/45 (40%), Positives = 30/45 (66%)
Frame = +3
Query: 555 SVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
S G ++PDIVFFG+ P +++V + + ++ + VMG+SL VY
Sbjct: 138 SCGGLIRPDIVFFGE--PVNDIDRVFELLDKAETLLVMGTSLQVY 180
Score = 34.7 bits (76), Expect = 2.2
Identities = 16/43 (37%), Positives = 24/43 (55%)
Frame = +1
Query: 94 SLGIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNY 222
S GIPD+RSED GLY ++ Y+ F +P + Y + +
Sbjct: 25 SSGIPDFRSED-GLYKEYGYELFSYEFFKNHPDIFYEYIKKEF 66
>UniRef50_Q88BY5 Cluster: NAD-dependent deacetylase; n=9;
Bacteria|Rep: NAD-dependent deacetylase - Pseudomonas
putida (strain KT2440)
Length = 262
Score = 57.2 bits (132), Expect = 4e-07
Identities = 29/74 (39%), Positives = 41/74 (55%), Gaps = 2/74 (2%)
Frame = +3
Query: 219 LYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQC 398
L+R ++ N HL I +L G S+VTQN+D LH +AGS V+ LHG+ V+C
Sbjct: 68 LWRRHQVSQAKPNSAHLSIPQLADAGWDVSVVTQNIDDLHERAGSSPVVHLHGSLMDVKC 127
Query: 399 LKC--PYEIDRHEL 434
C P E+ +L
Sbjct: 128 FGCHRPAELSPDQL 141
>UniRef50_Q5BVX8 Cluster: SJCHGC08739 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC08739 protein - Schistosoma
japonicum (Blood fluke)
Length = 179
Score = 56.8 bits (131), Expect = 5e-07
Identities = 28/66 (42%), Positives = 39/66 (59%), Gaps = 4/66 (6%)
Frame = +3
Query: 222 YRLAEIQLCATNXTHLCIRELEK----KGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYL 389
+R I+L N HL + + EK G+ ++TQNVD LH KAGS ++ELHG Y
Sbjct: 106 HRRETIRLRQPNSGHLALAQAEKLYVDSGRSFFVITQNVDDLHAKAGSGNILELHGNVYK 165
Query: 390 VQCLKC 407
+CL+C
Sbjct: 166 TRCLEC 171
>UniRef50_A3LN35 Cluster: NAD-dependent histone deacetylase SIR2;
n=1; Pichia stipitis|Rep: NAD-dependent histone
deacetylase SIR2 - Pichia stipitis (Yeast)
Length = 391
Score = 56.8 bits (131), Expect = 5e-07
Identities = 41/144 (28%), Positives = 67/144 (46%), Gaps = 3/144 (2%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL- 434
H I+ L+ KGK+ TQN+D L + G +K+I+ HG+ CL C H++
Sbjct: 182 HSFIKLLQDKGKLLRNYTQNIDNLESRVGIHPDKLIQCHGSFGSASCLTCSNRFAGHKIF 241
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
+ I ++ P + + I+ A + G +KPDI FFG+++PK
Sbjct: 242 EHIRHQHVPRCSTCWKTIQ------------------EAVIIHGVIKPDITFFGEDLPKK 283
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTV 686
+ + D V V+G+SL V
Sbjct: 284 FYRLLEPDCQTCDLVIVVGTSLKV 307
>UniRef50_Q9NTG7 Cluster: NAD-dependent deacetylase sirtuin-3,
mitochondrial precursor; n=22; Euteleostomi|Rep:
NAD-dependent deacetylase sirtuin-3, mitochondrial
precursor - Homo sapiens (Human)
Length = 399
Score = 44.8 bits (101), Expect(2) = 6e-07
Identities = 23/84 (27%), Positives = 41/84 (48%), Gaps = 3/84 (3%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRH 428
N TH +R L KG + + TQN+D L +G + K++E HGT C C
Sbjct: 207 NVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGE 266
Query: 429 ELQ-EILTENNPDMESSFSMIRPD 497
+++ +++ + P +++PD
Sbjct: 267 DIRADVMADRVPRCPVCTGVVKPD 290
Score = 31.5 bits (68), Expect(2) = 6e-07
Identities = 16/41 (39%), Positives = 26/41 (63%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
G +KPDIVFFG+ +P+ + V +D + ++G+SL V
Sbjct: 285 GVVKPDIVFFGEPLPQRFLLHV-VDFPMADLLLILGTSLEV 324
>UniRef50_A7SX90 Cluster: Predicted protein; n=3; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 306
Score = 56.4 bits (130), Expect = 6e-07
Identities = 39/141 (27%), Positives = 66/141 (46%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEI 443
H I +LE+ G + +QN+D L AG +VI+ HG+ C++C +++ ++E
Sbjct: 143 HRFIHQLEEHGHLLRNYSQNIDTLEQVAGITRVIQCHGSFSTASCMRCKHKVPCEAIKED 202
Query: 444 LTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVE 623
+ N + S+ S PD + +KPDIVFFG+++P
Sbjct: 203 IFRKNIPVCSTCS---PD------------------EEFPSIMKPDIVFFGESLPSNFYT 241
Query: 624 QVRKXVTSSDAVFVMGSSLTV 686
+ +D + V+GSSL V
Sbjct: 242 HLGDDSNKADLLIVIGSSLKV 262
>UniRef50_Q6FKU1 Cluster: Similar to sp|P53686 Saccharomyces
cerevisiae YPL015c; n=3; Saccharomycetales|Rep: Similar
to sp|P53686 Saccharomyces cerevisiae YPL015c - Candida
glabrata (Yeast) (Torulopsis glabrata)
Length = 364
Score = 56.4 bits (130), Expect = 6e-07
Identities = 43/149 (28%), Positives = 70/149 (46%), Gaps = 7/149 (4%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H ++ LEK G++ + TQN+D L +AG + ++E HG+ C+ C E + +
Sbjct: 89 HYLMKVLEKNGRLRRVYTQNIDTLEREAGIPDDYLVEAHGSFAKNHCIGCDKEFPLDDFK 148
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPK-- 611
+ L N + M + + D+ K E + +KP IVFFG+N+PK
Sbjct: 149 KALLRYN-----KYKM-KHNNDM-------KEFEYLRCPECEALIKPKIVFFGENLPKRF 195
Query: 612 ---YRVEQVRKXVTSSDAVFVMGSSLTVY 689
+ + S+ V V G+SLTVY
Sbjct: 196 FDSWDTDLEWLEEESNSIVIVAGTSLTVY 224
>UniRef50_Q6BPH5 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Saccharomycetaceae|Rep: Debaryomyces hansenii chromosome
E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 573
Score = 56.4 bits (130), Expect = 6e-07
Identities = 40/143 (27%), Positives = 65/143 (45%), Gaps = 2/143 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H I+ L+ KGK+ TQN+D L G EK+I+ HG+ C+ C Y++ ++
Sbjct: 332 HAFIKLLQNKGKLLRNYTQNIDNLESNVGIKPEKLIQCHGSFATASCVTCKYQVKGEKIY 391
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYR 617
+ E R NK + + +S G +KPDI FFG+ +P
Sbjct: 392 PKIREKEVPYCPKCKNAR-----KILLNK---EDAYVPESY-GVMKPDITFFGEPLPTRF 442
Query: 618 VEQVRKXVTSSDAVFVMGSSLTV 686
+R+ + D + +G+SL V
Sbjct: 443 HNMIRQDLMECDLLISIGTSLKV 465
>UniRef50_A1HU63 Cluster: Silent information regulator protein Sir2;
n=1; Thermosinus carboxydivorans Nor1|Rep: Silent
information regulator protein Sir2 - Thermosinus
carboxydivorans Nor1
Length = 243
Score = 56.0 bits (129), Expect = 8e-07
Identities = 43/150 (28%), Positives = 66/150 (44%)
Frame = +3
Query: 237 IQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYE 416
I + N H+ + L KG + ++TQN+D LH +AG+ V ELHG Y C+
Sbjct: 73 ILAASPNAAHIGLARLLAKGVLRGLMTQNIDGLHSRAGAGVVWELHGNLYRGYCM----- 127
Query: 417 IDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFG 596
E TE DM + G + ++ L+PD+VFFG
Sbjct: 128 -------ECRTEY--DMNGPLAAFLQRGQIP------------TSACCGAVLRPDVVFFG 166
Query: 597 DNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
D +P + ++SD + V+GS+L V
Sbjct: 167 DKLPAETWRHAERLASASDLMLVIGSTLEV 196
>UniRef50_Q7RP35 Cluster: Sir2-like protein; n=5; Plasmodium
(Vinckeia)|Rep: Sir2-like protein - Plasmodium yoelii
yoelii
Length = 1159
Score = 56.0 bits (129), Expect = 8e-07
Identities = 23/79 (29%), Positives = 45/79 (56%), Gaps = 2/79 (2%)
Frame = +3
Query: 177 CEVSESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSE 356
C+ S+ G + ++ E+ L TH+ I+EL K + ++TQN+D LH++ G++
Sbjct: 212 CQSSDENYVKFGNRKKKVVELHLALPTKTHIMIKELMNKNIIKFLITQNIDSLHYRCGTK 271
Query: 357 --KVIELHGTSYLVQCLKC 407
++ E+HG ++ +C C
Sbjct: 272 FSQISEIHGNIFIERCDFC 290
>UniRef50_A3ZMQ7 Cluster: Sir2 family, possible ADP
ribosyltransferase; n=1; Blastopirellula marina DSM
3645|Rep: Sir2 family, possible ADP ribosyltransferase -
Blastopirellula marina DSM 3645
Length = 252
Score = 55.6 bits (128), Expect = 1e-06
Identities = 33/103 (32%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Frame = +3
Query: 120 GGCWSVCP**SQTYTVSRICEVSESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKKGK 299
GG W+ +T + +E++ + +K E A N H + E G
Sbjct: 41 GGVWTKY----RTIYFDEFRQSAEARREYWRQKSEAHVEFSAAAPNAGHQILAAWEAHGV 96
Query: 300 VTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCP--YEID 422
++TQN+D LH AGS +V+ELHGT+ CL C +EID
Sbjct: 97 ARGLITQNIDGLHQIAGSRQVLELHGTAREATCLDCAARFEID 139
>UniRef50_Q8REC3 Cluster: NAD-dependent deacetylase; n=3;
Fusobacterium nucleatum|Rep: NAD-dependent deacetylase -
Fusobacterium nucleatum subsp. nucleatum
Length = 252
Score = 55.6 bits (128), Expect = 1e-06
Identities = 24/58 (41%), Positives = 37/58 (63%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRH 428
N H+ + ELEK G + +++TQN+D LH +G++ V+ELHG+ CL C DR+
Sbjct: 88 NKGHMALVELEKIGILKAVITQNIDDLHQVSGNKNVLELHGSLKRWYCLSCGKTADRN 145
Score = 35.1 bits (77), Expect = 1.7
Identities = 14/42 (33%), Positives = 26/42 (61%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
G ++PD+ +G+N+ + V + + +D + V G+SLTVY
Sbjct: 152 GVVRPDVTLYGENLNQSVVNEAIYQLEQADTLIVAGTSLTVY 193
>UniRef50_A6TNA0 Cluster: Silent information regulator protein Sir2;
n=1; Alkaliphilus metalliredigens QYMF|Rep: Silent
information regulator protein Sir2 - Alkaliphilus
metalliredigens QYMF
Length = 249
Score = 55.2 bits (127), Expect = 1e-06
Identities = 25/51 (49%), Positives = 32/51 (62%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYE 416
H + +LEKKG + SI TQNV LH AGS+ V ELHG ++C C +E
Sbjct: 92 HYILSDLEKKGMIRSIATQNVAGLHVMAGSQNVYELHGNIRKIRCNNCNHE 142
Score = 33.1 bits (72), Expect = 6.7
Identities = 12/40 (30%), Positives = 23/40 (57%)
Frame = +3
Query: 570 LKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
L+P ++ FG+ +P + + + D + V+G+SL VY
Sbjct: 162 LRPSVILFGETLPPKAWDSALRDIQKCDLLIVIGTSLEVY 201
>UniRef50_Q8IKW2 Cluster: Putative uncharacterized protein; n=1;
Plasmodium falciparum 3D7|Rep: Putative uncharacterized
protein - Plasmodium falciparum (isolate 3D7)
Length = 1304
Score = 55.2 bits (127), Expect = 1e-06
Identities = 24/70 (34%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Frame = +3
Query: 204 VLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGS--EKVIELHG 377
+ GK+ ++ E+ L + TH+ I EL K + ++TQN+D LHH+ G K E+HG
Sbjct: 236 IFGKRKKKVIELHLALPSKTHIMINELINKNIIKFMITQNIDSLHHRCGKHFSKTAEIHG 295
Query: 378 TSYLVQCLKC 407
+ +C C
Sbjct: 296 NIFTERCDFC 305
>UniRef50_Q5KDE0 Cluster: NAD-dependent histone deacetylase,
putative; n=2; Filobasidiella neoformans|Rep:
NAD-dependent histone deacetylase, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 413
Score = 55.2 bits (127), Expect = 1e-06
Identities = 40/144 (27%), Positives = 65/144 (45%), Gaps = 2/144 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH ++ + + + TQN+D L AG ++E HG+ CLKC E+DR E+
Sbjct: 144 THYLLQLFNRHNLLKRVFTQNIDTLETLAGLPPHLIVEAHGSFATAHCLKCRREVDREEV 203
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
+ ++R D + G + G +KPDIVFFG+ +P
Sbjct: 204 LKAGVRKG-------EVVRCDATLKAMGK---------GKKCGGLVKPDIVFFGEGLPD- 246
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTV 686
R ++ + D + V+G+SL V
Sbjct: 247 RFFKLVPELRKCDLLIVIGTSLQV 270
>UniRef50_Q67KQ0 Cluster: NAD-dependent deacetylase; n=1;
Symbiobacterium thermophilum|Rep: NAD-dependent
deacetylase - Symbiobacterium thermophilum
Length = 251
Score = 55.2 bits (127), Expect = 1e-06
Identities = 24/51 (47%), Positives = 33/51 (64%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKC 407
N H + L+++G + ++TQNVD LH AGS VIELHG+ QCL+C
Sbjct: 80 NPVHKVLAALQREGLLKRLITQNVDGLHQAAGSPDVIELHGSLRECQCLRC 130
>UniRef50_Q8A3H9 Cluster: NAD-dependent deacetylase; n=3;
Bacteroides|Rep: NAD-dependent deacetylase - Bacteroides
thetaiotaomicron
Length = 234
Score = 55.2 bits (127), Expect = 1e-06
Identities = 48/145 (33%), Positives = 70/145 (48%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + ELEK VT ++TQNVD LH +AGS ++ LHG V + PY + H +
Sbjct: 66 NRGHELLAELEKNFNVT-VITQNVDNLHERAGSSHIVHLHGELTKVCSSRDPY--NPHYI 122
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
+E+ E E M GD G + L+P IV+FG+ VP+
Sbjct: 123 KELKPE-----EYEVKM----GDKAGDGTQ---------------LRPFIVWFGEAVPE- 157
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTVY 689
+E + V +D ++G+SL VY
Sbjct: 158 -IETAVRYVEKADIFVIIGTSLNVY 181
>UniRef50_Q4UH74 Cluster: Sir2-like histone deacetylase, putative;
n=2; Theileria|Rep: Sir2-like histone deacetylase,
putative - Theileria annulata
Length = 928
Score = 54.8 bits (126), Expect = 2e-06
Identities = 27/75 (36%), Positives = 43/75 (57%), Gaps = 2/75 (2%)
Frame = +3
Query: 210 GKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTS 383
G ++ E L + +HLC+ EL ++ K+ I+TQNVD LH +G +K+ ELHG
Sbjct: 175 GNNKRKIVEFILALPSESHLCLLELLRRKKIRYIITQNVDGLHAVSGIPFDKLSELHGNV 234
Query: 384 YLVQCLKCPYEIDRH 428
++ +CL C R+
Sbjct: 235 FVQRCLFCHKRYQRN 249
>UniRef50_A7EC18 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 446
Score = 54.8 bits (126), Expect = 2e-06
Identities = 45/144 (31%), Positives = 71/144 (49%), Gaps = 2/144 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
+H + +EKKG + + TQN+D L +AG SEKVIE HG+ +C+ C E +
Sbjct: 108 SHAFVALIEKKGLLRMLFTQNIDCLERRAGVSSEKVIEAHGSFATQRCIDCKTEYPDDMM 167
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
++ + E +P + + P C G VK PDIVFFG+ +P+
Sbjct: 168 KKAIQEGDP-----ATCLVP----QCGG------------LVK----PDIVFFGEQLPE- 201
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTV 686
+ ++D + VMG+SL+V
Sbjct: 202 AFHSHKMIPATADLIIVMGTSLSV 225
>UniRef50_P06700 Cluster: NAD-dependent histone deacetylase SIR2;
n=13; Saccharomycetales|Rep: NAD-dependent histone
deacetylase SIR2 - Saccharomyces cerevisiae (Baker's
yeast)
Length = 562
Score = 54.8 bits (126), Expect = 2e-06
Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 10/151 (6%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL- 434
H I+ L+ KGK+ TQN+D L AG ++K+++ HG+ C+ C + + +
Sbjct: 326 HSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIF 385
Query: 435 QEILTENNPDMESSFSMIR---PDG---DVDCRGNK*KNSELHS-AQSVKGPLKPDIVFF 593
+I P + R P+G V ++ SE + G LKPDI FF
Sbjct: 386 NKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFF 445
Query: 594 GDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
G+ +P + +R+ + D + +G+SL V
Sbjct: 446 GEALPNKFHKSIREDILECDLLICIGTSLKV 476
>UniRef50_A7B9E8 Cluster: Putative uncharacterized protein; n=1;
Actinomyces odontolyticus ATCC 17982|Rep: Putative
uncharacterized protein - Actinomyces odontolyticus ATCC
17982
Length = 251
Score = 54.4 bits (125), Expect = 3e-06
Identities = 27/81 (33%), Positives = 40/81 (49%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + LE G++ +++TQN+D LH +AGS V ELHG + C C +
Sbjct: 80 NGAHRALASLEAAGRLDAVITQNIDGLHQRAGSRAVWELHGNWERLVCTSCGAVASLGDS 139
Query: 435 QEILTENNPDMESSFSMIRPD 497
+ + P S S +RPD
Sbjct: 140 VRVDGDPVPACPSCASQMRPD 160
>UniRef50_Q0AY57 Cluster: Regulatory protein, sir2 family; n=1;
Syntrophomonas wolfei subsp. wolfei str. Goettingen|Rep:
Regulatory protein, sir2 family - Syntrophomonas wolfei
subsp. wolfei (strain Goettingen)
Length = 253
Score = 54.0 bits (124), Expect = 3e-06
Identities = 23/45 (51%), Positives = 30/45 (66%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQC 398
H + E+EK G + +IVTQN+D LH KAGS+KVI +HG C
Sbjct: 85 HQVLAEMEKAGIIKAIVTQNIDNLHQKAGSQKVIPIHGNGARFLC 129
Score = 35.9 bits (79), Expect = 0.96
Identities = 17/42 (40%), Positives = 25/42 (59%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
G LKPD+V FG+++ Y + + + V+GSSLTVY
Sbjct: 158 GILKPDVVLFGEHIKNY--PDAMDRILGARVLVVIGSSLTVY 197
>UniRef50_Q8ZFR1 Cluster: NAD-dependent deacetylase; n=149; cellular
organisms|Rep: NAD-dependent deacetylase - Yersinia
pestis
Length = 278
Score = 47.6 bits (108), Expect(2) = 4e-06
Identities = 22/59 (37%), Positives = 34/59 (57%), Gaps = 1/59 (1%)
Frame = +3
Query: 249 ATNXTHLCIRELEKK-GKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEID 422
A N H + +LE G ++TQN+D LH +AGS++VI +HG V+C + +D
Sbjct: 103 APNAAHFALADLEAVLGDNLVLITQNIDNLHERAGSKRVIHMHGELLKVRCTQSGQVLD 161
Score = 25.8 bits (54), Expect(2) = 4e-06
Identities = 17/62 (27%), Positives = 33/62 (53%)
Frame = +3
Query: 504 VDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLT 683
+D +G+ + H Q PL+P IV+FG+ +P ++ + + + +D +G+S
Sbjct: 160 LDWQGDLSADERCHCCQ-FPSPLRPHIVWFGE-MP-MGMDDIYQALAEADFFISIGTSGH 216
Query: 684 VY 689
VY
Sbjct: 217 VY 218
>UniRef50_Q0LIC7 Cluster: Silent information regulator protein Sir2;
n=2; Bacteria|Rep: Silent information regulator protein
Sir2 - Herpetosiphon aurantiacus ATCC 23779
Length = 244
Score = 39.5 bits (88), Expect(2) = 4e-06
Identities = 24/92 (26%), Positives = 42/92 (45%), Gaps = 3/92 (3%)
Frame = +3
Query: 231 AEIQLCATNXTHLCIRELEK---KGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCL 401
+++Q N H + E+ K + +++TQN+D LH AGS ++E HG+ +C
Sbjct: 67 SQLQTTQPNAAHRALARFEQSLGKHQRFTLITQNIDGLHQLAGSRNLVEFHGSLRQSRCS 126
Query: 402 KCPYEIDRHELQEILTENNPDMESSFSMIRPD 497
+ Q T+ P + +RPD
Sbjct: 127 DEQCDQPSFVDQRAHTQTLPLCPTCGKPLRPD 158
Score = 33.9 bits (74), Expect(2) = 4e-06
Identities = 14/41 (34%), Positives = 24/41 (58%)
Frame = +3
Query: 567 PLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
PL+PDIV F + +P + Q ++ + D +G+S TV+
Sbjct: 154 PLRPDIVLFEEAIPVWAETQAKRSLRECDFFLAVGTSGTVF 194
>UniRef50_UPI0000E49846 Cluster: PREDICTED: similar to Sirtuin
(silent mating type information regulation 2 homolog) 6
(S. cerevisiae); n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to Sirtuin (silent mating type
information regulation 2 homolog) 6 (S. cerevisiae) -
Strongylocentrotus purpuratus
Length = 521
Score = 53.6 bits (123), Expect = 4e-06
Identities = 41/164 (25%), Positives = 76/164 (46%), Gaps = 2/164 (1%)
Frame = +3
Query: 210 GKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTS 383
GKK TH+ + ELE++GK+ +++QN+D LH ++G +++ ELHG
Sbjct: 23 GKKPEANVTFDTAKPTATHMALVELERRGKLQYLISQNIDGLHLRSGFPKDRLAELHGNM 82
Query: 384 YLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVK 563
++ QC +C Q I P + ++P G+ + S+ + +
Sbjct: 83 FVEQCHRC-------RRQTIRAMPVPTLG-----LKPTGN--------RCSDKPGRGTCR 122
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSS 695
G L I+ + D +P+ + Q + + SD +G+SL + S
Sbjct: 123 GKLHDTILDWEDALPETDLTQAEEHLRKSDLSICLGTSLQIIPS 166
>UniRef50_A7EMW8 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 533
Score = 53.6 bits (123), Expect = 4e-06
Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 19/161 (11%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH I+ L+ KGK+ + TQN+D + AG E VI+ HG+ C +C ++ E+
Sbjct: 278 THQFIKVLQDKGKLLTNYTQNIDGIESAAGILPENVIQCHGSFATATCQQCSTQVKGTEV 337
Query: 435 -QEILTEN-------------NPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGP- 569
EI N P + + R + + KN + + + P
Sbjct: 338 FPEIKAGNIPRCKVKGCKIPAPPPPKQTLKRKRSSNGGSKKRGRSKNDDENEEDDIPQPG 397
Query: 570 -LKPDIVFFGDNVPKYRVEQVRKXVTSS-DAVFVMGSSLTV 686
+KPDI FFG+++P +++ K D V +G+SL V
Sbjct: 398 IMKPDITFFGESLPDKFADRLSKHDRDQVDLVITIGTSLKV 438
>UniRef50_A6RXY5 Cluster: Putative uncharacterized protein; n=2;
Pezizomycotina|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 446
Score = 53.6 bits (123), Expect = 4e-06
Identities = 45/144 (31%), Positives = 71/144 (49%), Gaps = 2/144 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
+H + +EKKG + + TQN+D L +AG SEKVIE HG+ +C+ C E +
Sbjct: 108 SHAFVALIEKKGLLRMLFTQNIDCLERRAGVSSEKVIEAHGSFATQRCIDCKTEYPDDMM 167
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
++ + + +P + + P C G VK PDIVFFG+ +P+
Sbjct: 168 KKAIEDGDP-----ATCLVP----QCGG------------LVK----PDIVFFGEQLPE- 201
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTV 686
+ ++D V VMG+SL+V
Sbjct: 202 AFHANKMIPATADLVIVMGTSLSV 225
>UniRef50_Q8R104 Cluster: NAD-dependent deacetylase sirtuin-3; n=8;
Deuterostomia|Rep: NAD-dependent deacetylase sirtuin-3 -
Mus musculus (Mouse)
Length = 257
Score = 41.9 bits (94), Expect(2) = 5e-06
Identities = 22/84 (26%), Positives = 39/84 (46%), Gaps = 3/84 (3%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRH 428
N TH +R L K + + TQN+D L +G + K++E HGT C C
Sbjct: 65 NVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGE 124
Query: 429 EL-QEILTENNPDMESSFSMIRPD 497
++ +++ + P +++PD
Sbjct: 125 DIWADVMADRVPRCPVCTGVVKPD 148
Score = 31.1 bits (67), Expect(2) = 5e-06
Identities = 16/41 (39%), Positives = 24/41 (58%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
G +KPDIVFFG+ +P R +D + ++G+SL V
Sbjct: 143 GVVKPDIVFFGEQLPA-RFLLHMADFALADLLLILGTSLEV 182
>UniRef50_A2F9H1 Cluster: Transcriptional regulator, Sir2 family
protein; n=2; Trichomonas vaginalis|Rep: Transcriptional
regulator, Sir2 family protein - Trichomonas vaginalis
G3
Length = 304
Score = 53.2 bits (122), Expect = 6e-06
Identities = 43/137 (31%), Positives = 62/137 (45%), Gaps = 2/137 (1%)
Frame = +3
Query: 282 LEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQEILTEN 455
+ KKG + TQN+D L AG +K++E HGT C +C E E+++ L
Sbjct: 103 MAKKGILLKQYTQNIDGLERIAGVPEDKLVESHGTFSTAHCTECKKEWKLEEIRDKLLLG 162
Query: 456 NPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRK 635
P + + D DC KG +KPDIVFFG+N+P R
Sbjct: 163 KP-LHCT--------DPDC----------------KGFIKPDIVFFGENLPTSFQHNARI 197
Query: 636 XVTSSDAVFVMGSSLTV 686
+ S D + + G+SL V
Sbjct: 198 DLRSCDMLLISGTSLKV 214
>UniRef50_A5DJ74 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 522
Score = 53.2 bits (122), Expect = 6e-06
Identities = 39/143 (27%), Positives = 66/143 (46%), Gaps = 2/143 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H I+ L+ KG + TQN+D L G S++V++ HG+ C+ C I HE+
Sbjct: 281 HAFIKTLDDKGILLRNYTQNIDNLESNVGINSDRVVQCHGSFATATCVTCKNTIPGHEIF 340
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYR 617
E + N ++ + R + + +S G +KPDI FFG+ +P
Sbjct: 341 ECI--RNKEVAYCTKC------TNSRLALMDKDDAYVPESY-GVMKPDITFFGELLPAKF 391
Query: 618 VEQVRKXVTSSDAVFVMGSSLTV 686
+ + + + D V +G+SL V
Sbjct: 392 HDTINEDLHECDLVISVGTSLKV 414
>UniRef50_Q9JN05 Cluster: NAD-dependent deacetylase; n=13;
Campylobacter|Rep: NAD-dependent deacetylase -
Campylobacter jejuni
Length = 233
Score = 53.2 bits (122), Expect = 6e-06
Identities = 32/89 (35%), Positives = 49/89 (55%), Gaps = 4/89 (4%)
Frame = +3
Query: 153 QTYTVSRICEVS---ESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKK-GKVTSIVTQ 320
+ Y V +C + ++ KVL R A++Q N H I +L++K GK ++TQ
Sbjct: 29 EEYDVMEVCSATGFRKNPKKVLDFYDARRAQLQNVKPNHAHEKIAQLKEKWGKNLFVITQ 88
Query: 321 NVDRLHHKAGSEKVIELHGTSYLVQCLKC 407
NVD L +AG + V+ LHG ++CLKC
Sbjct: 89 NVDDLLERAGCKDVVHLHGFLPELRCLKC 117
>UniRef50_Q0LFI4 Cluster: Silent information regulator protein Sir2;
n=1; Herpetosiphon aurantiacus ATCC 23779|Rep: Silent
information regulator protein Sir2 - Herpetosiphon
aurantiacus ATCC 23779
Length = 171
Score = 52.8 bits (121), Expect = 8e-06
Identities = 23/48 (47%), Positives = 32/48 (66%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQC 398
N H+ + +LE+ +I+TQN+D LH +AGS +VIELHGT V C
Sbjct: 7 NAGHVALAQLEQHIPSVTIITQNIDGLHQRAGSTRVIELHGTINTVSC 54
>UniRef50_O25849 Cluster: NAD-dependent deacetylase; n=11;
Bacteria|Rep: NAD-dependent deacetylase - Helicobacter
pylori (Campylobacter pylori)
Length = 229
Score = 52.8 bits (121), Expect = 8e-06
Identities = 32/81 (39%), Positives = 47/81 (58%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + ELEK +V +I+TQNVD LH +AGS +++ LHG V+ K P + R E
Sbjct: 66 NKAHKALAELEKHYQV-NIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWE- 123
Query: 435 QEILTENNPDMESSFSMIRPD 497
+++ N D+ S +RPD
Sbjct: 124 KDL---NLGDLAKDKSQLRPD 141
>UniRef50_A5K3P4 Cluster: Putative uncharacterized protein; n=1;
Plasmodium vivax|Rep: Putative uncharacterized protein -
Plasmodium vivax
Length = 1259
Score = 52.4 bits (120), Expect = 1e-05
Identities = 20/70 (28%), Positives = 42/70 (60%), Gaps = 2/70 (2%)
Frame = +3
Query: 204 VLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSE--KVIELHG 377
+ G + ++ ++ L TH+ I+EL + + ++TQN+D LH++ G++ K+ E+HG
Sbjct: 327 IFGNRKKKVIDLHLALPTKTHIMIKELMNRNIIKFLITQNIDSLHYRCGTKFSKISEIHG 386
Query: 378 TSYLVQCLKC 407
++ +C C
Sbjct: 387 NIFIERCDFC 396
>UniRef50_A4VDQ9 Cluster: Chromatin regulatory protein sir2; n=1;
Tetrahymena thermophila SB210|Rep: Chromatin regulatory
protein sir2 - Tetrahymena thermophila SB210
Length = 279
Score = 52.4 bits (120), Expect = 1e-05
Identities = 42/144 (29%), Positives = 68/144 (47%), Gaps = 2/144 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLKCPYEIDRHEL 434
+H I EL K+ + +TQN+D L KAG +K +I+ HG C++C E
Sbjct: 103 SHKFITELAKQNLLYLNITQNIDGLELKAGLDKKYLIQAHGNLEKSHCIECHKEDTIEYF 162
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
+E +++ D V+CR K + +G LKP + FFG+ +P Y
Sbjct: 163 KE-------------GVLKSDDAVNCRKTK----------NCQGKLKPSVTFFGEKLPFY 199
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTV 686
++ + +D + VMG+SL V
Sbjct: 200 -FYKIPLQMRFADLIIVMGTSLKV 222
>UniRef50_Q5AQ47 Cluster: Potential Sir2 family histone deacetylase;
n=2; Candida albicans|Rep: Potential Sir2 family histone
deacetylase - Candida albicans (Yeast)
Length = 657
Score = 52.4 bits (120), Expect = 1e-05
Identities = 45/163 (27%), Positives = 72/163 (44%), Gaps = 22/163 (13%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL- 434
H I+ L+ K K+ TQN+D L AG E +I+ HG+ C+ C Y++D +
Sbjct: 373 HSFIKLLQDKNKLLRNYTQNIDNLESYAGIHKENLIQCHGSFATASCITCGYKVDGEIIF 432
Query: 435 QEILTENNPDM----ESSFSMIRPDGDVDCRGNK*K---------------NSELHSAQS 557
EI + P E S+++ + K K E + +S
Sbjct: 433 PEIKNKEIPYCPKCNEVKQSILKKGKKTKSKSKKKKKKKNKPYDDDDEEEEEGETYFHES 492
Query: 558 VKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
G +KPDI FFG+ +P+ + + + D V V+G+SL V
Sbjct: 493 F-GVMKPDITFFGEQLPENFKIAINQDINKVDLVLVIGTSLKV 534
>UniRef50_A5DSX8 Cluster: NAD-dependent histone deacetylase SIR2;
n=1; Lodderomyces elongisporus NRRL YB-4239|Rep:
NAD-dependent histone deacetylase SIR2 - Lodderomyces
elongisporus (Yeast) (Saccharomyces elongisporus)
Length = 568
Score = 52.4 bits (120), Expect = 1e-05
Identities = 38/143 (26%), Positives = 67/143 (46%), Gaps = 2/143 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H I L++KGK+ TQN+D L AG EK+++ HG+ C+ C + +
Sbjct: 328 HSFIYLLQQKGKLLRNYTQNIDNLESYAGIVPEKMVQCHGSFATATCVTCRNTVAGETIF 387
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYR 617
+ + + E + P + + KN + + +S G KPDI FFG+ +P
Sbjct: 388 KTIRQK----EIPYC---PRCEAKKKSILKKNDDYYFPESY-GVYKPDITFFGEALPSRF 439
Query: 618 VEQVRKXVTSSDAVFVMGSSLTV 686
+ + ++ D + +G+SL V
Sbjct: 440 HDLINTDISECDLLISIGTSLKV 462
>UniRef50_Q5P3W1 Cluster: NAD-dependent deacetylase 2; n=4;
Proteobacteria|Rep: NAD-dependent deacetylase 2 -
Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum
(strain EbN1))
Length = 260
Score = 52.0 bits (119), Expect = 1e-05
Identities = 27/79 (34%), Positives = 44/79 (55%), Gaps = 1/79 (1%)
Frame = +3
Query: 180 EVSESKAKVLGKKLYRL-AEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSE 356
E+ E+ +V K + + A + A N H I LE + ++TQNVD LH AGS
Sbjct: 62 EMMEAHPEVAWKYIAEIEANCRGAAPNIAHRIIAALEHERPGVWVLTQNVDGLHRAAGSR 121
Query: 357 KVIELHGTSYLVQCLKCPY 413
+IE+HG+ + ++C +C +
Sbjct: 122 NLIEIHGSVHRLRCTECKH 140
>UniRef50_A5AF92 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 343
Score = 52.0 bits (119), Expect = 1e-05
Identities = 23/56 (41%), Positives = 36/56 (64%), Gaps = 2/56 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEID 422
TH+ + ELEK G + +++QN+D LH ++G +K+ ELHG S++ C C E D
Sbjct: 126 THMALVELEKAGILKFVISQNIDGLHLRSGIPRDKLAELHGNSFMEICSSCGIEYD 181
>UniRef50_UPI00004997CB Cluster: Sir2 family transcriptional
regulator; n=2; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 346
Score = 51.6 bits (118), Expect = 2e-05
Identities = 46/142 (32%), Positives = 65/142 (45%), Gaps = 2/142 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH + L K G ++ + TQN+D L ++G +EK++ HG Y CLKC
Sbjct: 176 THYFLTYLNKLGYISMLFTQNIDGLEIQSGFPNEKLVMAHGNYYSGHCLKCKKSFK---- 231
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
Q +N +R DG V C S KG +KPDIVFFG+ +P+
Sbjct: 232 QSYFIDN----------VR-DGKV-C-----------YCDSCKGLVKPDIVFFGEGLPQQ 268
Query: 615 RVEQVRKXVTSSDAVFVMGSSL 680
K V D + V+G+SL
Sbjct: 269 FFNNFEK-VEECDLLIVLGTSL 289
>UniRef50_A0NQ49 Cluster: Silent information regulator protein Sir2;
n=1; Stappia aggregata IAM 12614|Rep: Silent information
regulator protein Sir2 - Stappia aggregata IAM 12614
Length = 260
Score = 51.6 bits (118), Expect = 2e-05
Identities = 21/53 (39%), Positives = 31/53 (58%), Gaps = 2/53 (3%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKC 407
N H + L + GK+ ++TQNVD LH +AG + ++E+HG S CL C
Sbjct: 94 NAAHFALTTLARSGKLVCLITQNVDGLHQRAGFPDDLLVEIHGNSTFASCLSC 146
Score = 36.3 bits (80), Expect = 0.72
Identities = 20/48 (41%), Positives = 26/48 (54%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFS 243
GIPD+RS G++ S +P+QYQ+FV R W R W R S
Sbjct: 38 GIPDFRSPG-GIW--SKRQPVQYQDFVDDEDSRLEDWDRRLEDWDRRS 82
>UniRef50_Q54QE6 Cluster: Zn finger-containing protein; n=5;
Eukaryota|Rep: Zn finger-containing protein -
Dictyostelium discoideum AX4
Length = 512
Score = 51.2 bits (117), Expect = 2e-05
Identities = 40/144 (27%), Positives = 64/144 (44%), Gaps = 2/144 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H I+ L KG + TQN+D L AG + K++E HG+ C+ C E ++
Sbjct: 323 HYFIKLLSDKGLLLRNFTQNIDTLERIAGIPANKLVEAHGSFATSHCVSCKKEYSTEYVK 382
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYR 617
E + ++ + E KG +KPDIVFFG+++P
Sbjct: 383 ERIFKD------------------------ELPECTETSGCKGIVKPDIVFFGESLPSRF 418
Query: 618 VEQVRKXVTSSDAVFVMGSSLTVY 689
+ R+ T D + V+G+SL V+
Sbjct: 419 NDCAREDFTKCDLLLVIGTSLKVH 442
>UniRef50_Q54P49 Cluster: Zn finger-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: Zn finger-containing
protein - Dictyostelium discoideum AX4
Length = 456
Score = 51.2 bits (117), Expect = 2e-05
Identities = 44/162 (27%), Positives = 71/162 (43%), Gaps = 2/162 (1%)
Frame = +3
Query: 207 LGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGS--EKVIELHGT 380
L K LY + + C H I+ L KG + QN D L AG +K+IE HG+
Sbjct: 240 LSKDLYPSGKFK-CTP--VHYFIKLLSDKGLLLRNYAQNADTLERIAGIPLDKLIEAHGS 296
Query: 381 SYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSV 560
+ +C C E + +++ + N+P + P C+ Q
Sbjct: 297 FAVSRCTNCGLEYSQEYIKDSIFNNDP-----LKSVVP----RCK----------VVQCN 337
Query: 561 KGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
+KPDIVFFG+++P + + + D + V+G+SL V
Sbjct: 338 NAVIKPDIVFFGESLPPIFNQNILDDINRCDCLIVIGTSLKV 379
>UniRef50_Q4WFZ3 Cluster: SIR2 family histone deacetylase, putative;
n=4; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Aspergillus fumigatus (Sartorya
fumigata)
Length = 403
Score = 51.2 bits (117), Expect = 2e-05
Identities = 47/146 (32%), Positives = 66/146 (45%), Gaps = 4/146 (2%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKC--PYEIDRH 428
TH + LEKKG + + TQN+D L G +K++ HG+ +C KC PY D
Sbjct: 164 THAFLALLEKKGLLHFVFTQNIDGLERDVGIPEDKILNAHGSWRTQRCWKCKTPYPDDLM 223
Query: 429 ELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
+ Q I T P + DC G +KPDIVFFG +P
Sbjct: 224 K-QAISTGTVPYCQVP----------DCGG----------------AVKPDIVFFGQPLP 256
Query: 609 KYRVEQVRKXVTSSDAVFVMGSSLTV 686
++ K V+ +D + VMG+SL V
Sbjct: 257 A-EFDEKEKEVSEADMMLVMGTSLKV 281
>UniRef50_A6RRE3 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 526
Score = 51.2 bits (117), Expect = 2e-05
Identities = 46/159 (28%), Positives = 66/159 (41%), Gaps = 17/159 (10%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPY------- 413
TH I L+ GK+ + TQN+D + AG +K+I HG+ C C +
Sbjct: 274 THQFIALLQAHGKLLTNYTQNIDNIESMAGISPDKIIHCHGSFATATCQVCGHKVKGDAI 333
Query: 414 --EIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSV-----KGPL 572
+I + EN P S S R G K KN + G +
Sbjct: 334 FDDIKNGHIPRCKMENCPPGSQS-SNPRKRKKSSMGGKKKKNGQYSDDDESDDIPESGIM 392
Query: 573 KPDIVFFGDNVPKYRVEQVRKXVTSS-DAVFVMGSSLTV 686
KPDI FFG+N+P +++ K D V +G+SL V
Sbjct: 393 KPDITFFGENLPDVFSDRLSKHDRDQVDLVITIGTSLKV 431
>UniRef50_A4QX96 Cluster: Putative uncharacterized protein; n=2;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 534
Score = 43.2 bits (97), Expect(2) = 3e-05
Identities = 23/86 (26%), Positives = 42/86 (48%), Gaps = 3/86 (3%)
Frame = +3
Query: 249 ATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEID 422
A +H + L +KG + + TQN+D L AG + V+E HG+ +C+ C E
Sbjct: 103 APTISHAFVALLARKGLLAMLFTQNIDGLEKAAGVPPDLVVEAHGSFDSQRCIDCAQEFP 162
Query: 423 RHELQ-EILTENNPDMESSFSMIRPD 497
+++ + T + P +++PD
Sbjct: 163 AADMRAHVATSSVPHCGKCGGLVKPD 188
Score = 27.5 bits (58), Expect(2) = 3e-05
Identities = 10/15 (66%), Positives = 13/15 (86%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVP 608
G +KPDIVFFG+ +P
Sbjct: 183 GLVKPDIVFFGEQLP 197
>UniRef50_Q7SB01 Cluster: Putative uncharacterized protein
NCU07624.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU07624.1 - Neurospora crassa
Length = 437
Score = 50.8 bits (116), Expect = 3e-05
Identities = 21/69 (30%), Positives = 40/69 (57%), Gaps = 2/69 (2%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH+ + EL+++G + +++QN D LH ++G ++ + ELHG + + C C E R +
Sbjct: 85 THMALVELQERGILKGLISQNCDGLHRRSGIRADMISELHGNTNIEHCKNCGKEFLRADF 144
Query: 435 QEILTENNP 461
+ +N P
Sbjct: 145 YAVAPDNRP 153
>UniRef50_A4QUX8 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 460
Score = 50.8 bits (116), Expect = 3e-05
Identities = 53/164 (32%), Positives = 77/164 (46%), Gaps = 2/164 (1%)
Frame = +3
Query: 204 VLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHG 377
VL K+LY + Q +H I L KKG + TQN+D L +AG EKVIE HG
Sbjct: 96 VLAKELYP-GKFQ---PTISHAFIALLSKKGLLQMNFTQNIDCLERQAGVPGEKVIEAHG 151
Query: 378 TSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQS 557
+ C+ E +E+ PD E ++ + ++ R S
Sbjct: 152 SFATQSCI---------ECKELF----PDDEM---LLHVEKEIVPR-----------CAS 184
Query: 558 VKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
G +KP+IVFFG+ +P+ E+ V SD ++G+SLTVY
Sbjct: 185 CNGLVKPNIVFFGEPLPRTFSEKCH-LVAESDLAIIIGTSLTVY 227
>UniRef50_Q9FE17 Cluster: Sir2-like protein; n=9; Magnoliophyta|Rep:
Sir2-like protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 473
Score = 50.4 bits (115), Expect = 4e-05
Identities = 40/144 (27%), Positives = 66/144 (45%), Gaps = 2/144 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH+ + ELE+ G + +++QNVD LH ++G EK+ ELHG S++ C C E R
Sbjct: 95 THMALVELERAGILKFVISQNVDGLHLRSGIPREKLSELHGDSFMEMCPSCGAEYLR--- 151
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
D +V+ G K + S S + LK ++ + D +P
Sbjct: 152 --------------------DFEVETIGLK-ETSRKCSVEKCGAKLKDTVLDWEDALPPK 190
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTV 686
++ K +D V +G+SL +
Sbjct: 191 EIDPAEKHCKKADLVLCLGTSLQI 214
>UniRef50_Q298C7 Cluster: GA18650-PA; n=1; Drosophila
pseudoobscura|Rep: GA18650-PA - Drosophila pseudoobscura
(Fruit fly)
Length = 381
Score = 50.4 bits (115), Expect = 4e-05
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL- 434
H IR L +KG + TQN+D L AG EK+IE HG+ + C+ C E D +
Sbjct: 148 HYFIRLLHEKGLLLRHYTQNIDTLDRLAGIPDEKLIEAHGSFHTNHCIGCKKEYDMAWMK 207
Query: 435 QEILTENNPDMESSFSMIRPD 497
+EI ++ P S +++PD
Sbjct: 208 KEIFSDRLPTCTSCKKIVKPD 228
Score = 37.9 bits (84), Expect = 0.24
Identities = 18/53 (33%), Positives = 30/53 (56%)
Frame = +3
Query: 531 NSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
+ L + S K +KPDIVFFG+N+P+ + D + +MG++L V+
Sbjct: 212 SDRLPTCTSCKKIVKPDIVFFGENLPEKFHNSLDGDFKECDLLIIMGTTLEVH 264
>UniRef50_Q607X6 Cluster: NAD-dependent deacetylase; n=1;
Methylococcus capsulatus|Rep: NAD-dependent deacetylase
- Methylococcus capsulatus
Length = 255
Score = 50.4 bits (115), Expect = 4e-05
Identities = 42/164 (25%), Positives = 65/164 (39%)
Frame = +3
Query: 198 AKVLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHG 377
A V G +R + N H I L +++TQNVD LH +AGS I LHG
Sbjct: 61 ALVWGWYEWRRTRVLRAEPNPAHYAIAALAADCPRLTLITQNVDDLHERAGSADPIRLHG 120
Query: 378 TSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQS 557
+ + +C C E L PD + P C
Sbjct: 121 SLHHPRCSAC-------EAPYRLPPGIPDEPEGGRRVDPPRCARC--------------- 158
Query: 558 VKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
P++P +V+ G+N+P+ + R+ D +F +G+S V+
Sbjct: 159 -GAPVRPGVVWLGENLPQAAWDAARQAAEDCDLMFSIGTSALVW 201
>UniRef50_Q88ZA0 Cluster: NAD-dependent deacetylase; n=4;
Lactobacillus|Rep: NAD-dependent deacetylase -
Lactobacillus plantarum
Length = 234
Score = 50.4 bits (115), Expect = 4e-05
Identities = 22/59 (37%), Positives = 35/59 (59%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHE 431
N H + L ++G+ S++TQN+D L+ A + +++E HG Y V C KC +D HE
Sbjct: 79 NVIHQKMAALTQQGRA-SVITQNIDNLYGVAKTAQLVEFHGNLYQVYCTKCGQHVDWHE 136
>UniRef50_Q95Q89 Cluster: Yeast sir related protein 2.4; n=2;
Caenorhabditis|Rep: Yeast sir related protein 2.4 -
Caenorhabditis elegans
Length = 299
Score = 50.0 bits (114), Expect = 5e-05
Identities = 40/153 (26%), Positives = 71/153 (46%), Gaps = 2/153 (1%)
Frame = +3
Query: 234 EIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKC 407
+ Q+ +H I L K G + +I+TQNVD L K G E +IE+HG +L C C
Sbjct: 95 DFQVARPGVSHKSILALHKAGYIKTIITQNVDGLDRKVGIPVEDLIEVHGNLFLEVCQSC 154
Query: 408 PYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIV 587
E R E+ +++ + P G +C GNK + +S +G L+ +
Sbjct: 155 FSEYVREEI--VMSVG----------LCPTGR-NCEGNK------RTGRSCRGKLRDATL 195
Query: 588 FFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
+ + ++++RK + + +G+SL +
Sbjct: 196 DWDTEISLNHLDRIRKAWKQTSHLLCIGTSLEI 228
>UniRef50_Q89LY4 Cluster: NAD-dependent deacetylase 1; n=12;
Proteobacteria|Rep: NAD-dependent deacetylase 1 -
Bradyrhizobium japonicum
Length = 254
Score = 50.0 bits (114), Expect = 5e-05
Identities = 23/57 (40%), Positives = 35/57 (61%), Gaps = 4/57 (7%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKC--PYEID 422
H + L + GKV +++TQN+D LH +G E VIELHG + +C+ C Y++D
Sbjct: 90 HRALASLYRAGKVPAVITQNIDNLHQASGFAHEHVIELHGNTTYARCVGCGQTYQLD 146
Score = 33.1 bits (72), Expect = 6.7
Identities = 17/52 (32%), Positives = 27/52 (51%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPD+RS G++ R+ +PI + FV + R W R + F+ +P
Sbjct: 38 GIPDFRSPG-GIWTRN--RPIPFDGFVASQEARDESWRRRFAMEETFAAARP 86
>UniRef50_Q6C219 Cluster: Yarrowia lipolytica chromosome F of strain
CLIB122 of Yarrowia lipolytica; n=1; Yarrowia
lipolytica|Rep: Yarrowia lipolytica chromosome F of
strain CLIB122 of Yarrowia lipolytica - Yarrowia
lipolytica (Candida lipolytica)
Length = 320
Score = 49.6 bits (113), Expect = 7e-05
Identities = 37/129 (28%), Positives = 58/129 (44%), Gaps = 2/129 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAGSE--KVIELHGTSYLVQCLKCPYEIDRHEL 434
TH ++ L+ KGK+ I TQN+D L H AG E K+++ HG ++ C +C ++ L
Sbjct: 134 THAFLKLLQDKGKLLRIYTQNIDDLEHIAGIEESKMVQCHGAFHMATCRQCGAKVTCESL 193
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
+ + M CR + +G +KPDIVFFG+ +P
Sbjct: 194 RPEIVAGEIPM--------------CRRKR-----------CEGVIKPDIVFFGEALPDR 228
Query: 615 RVEQVRKXV 641
VR +
Sbjct: 229 FRHMVRSDI 237
>UniRef50_Q8IXJ6 Cluster: NAD-dependent deacetylase sirtuin-2; n=31;
Coelomata|Rep: NAD-dependent deacetylase sirtuin-2 -
Homo sapiens (Human)
Length = 389
Score = 49.6 bits (113), Expect = 7e-05
Identities = 46/143 (32%), Positives = 66/143 (46%), Gaps = 2/143 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLKCPYEIDRHELQ 437
H +R L+ KG + TQN+D L AG E+ ++E HGT Y C+ RHE
Sbjct: 149 HYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASC---RHEYP 205
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYR 617
+ E FS + P + DC QS+ +KPDIVFFG+++P
Sbjct: 206 LSWMK-----EKIFSEVTPKCE-DC-------------QSL---VKPDIVFFGESLPARF 243
Query: 618 VEQVRKXVTSSDAVFVMGSSLTV 686
++ D + VMG+SL V
Sbjct: 244 FSCMQSDFLKVDLLLVMGTSLQV 266
>UniRef50_UPI000051AA14 Cluster: PREDICTED: similar to NAD-dependent
deacetylase sirtuin-1 (hSIRT1) (hSIR2) (SIR2-like
protein 1); n=1; Apis mellifera|Rep: PREDICTED: similar
to NAD-dependent deacetylase sirtuin-1 (hSIRT1) (hSIR2)
(SIR2-like protein 1) - Apis mellifera
Length = 868
Score = 49.2 bits (112), Expect = 1e-04
Identities = 21/59 (35%), Positives = 34/59 (57%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQE 440
H I+ L+K+ K+ +QN+D L AG E VIE HG+ C +C Y++ +++E
Sbjct: 277 HRFIKMLDKQKKLLRNYSQNIDTLEQVAGIENVIECHGSFATASCTRCKYQVKADDIRE 335
Score = 36.3 bits (80), Expect = 0.72
Identities = 17/39 (43%), Positives = 24/39 (61%)
Frame = +3
Query: 570 LKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
+KPDIVFFG+ +P + + K D + V+GSSL V
Sbjct: 350 MKPDIVFFGEGLPDAFHDAMAKDKDECDLLIVIGSSLKV 388
>UniRef50_Q8N6T7-2 Cluster: Isoform 2 of Q8N6T7 ; n=5;
Catarrhini|Rep: Isoform 2 of Q8N6T7 - Homo sapiens
(Human)
Length = 328
Score = 49.2 bits (112), Expect = 1e-04
Identities = 21/51 (41%), Positives = 35/51 (68%), Gaps = 2/51 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKC 407
TH+ + +LE+ G + +V+QNVD LH ++G +K+ ELHG ++ +C KC
Sbjct: 94 THMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKC 144
>UniRef50_Q1QTH0 Cluster: Silent information regulator protein Sir2;
n=2; Oceanospirillales|Rep: Silent information regulator
protein Sir2 - Chromohalobacter salexigens (strain DSM
3043 / ATCC BAA-138 / NCIMB13768)
Length = 242
Score = 49.2 bits (112), Expect = 1e-04
Identities = 21/51 (41%), Positives = 30/51 (58%)
Frame = +3
Query: 225 RLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHG 377
R + + N H + ELE+ G S++TQN+D LH +AGS V+ LHG
Sbjct: 61 RREQTRQATPNAAHRALAELEQAGFQVSVITQNIDDLHERAGSRDVLHLHG 111
Score = 38.3 bits (85), Expect = 0.18
Identities = 18/39 (46%), Positives = 27/39 (69%)
Frame = +3
Query: 570 LKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
L+PD+V+FG+ VP+Y Q + V +D V V+G+SL V
Sbjct: 145 LRPDVVWFGEPVPRY--AQACEIVAEADLVLVVGTSLAV 181
>UniRef50_Q8N6T7 Cluster: Mono-ADP-ribosyltransferase sirtuin-6;
n=22; Euteleostomi|Rep: Mono-ADP-ribosyltransferase
sirtuin-6 - Homo sapiens (Human)
Length = 355
Score = 49.2 bits (112), Expect = 1e-04
Identities = 21/51 (41%), Positives = 35/51 (68%), Gaps = 2/51 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKC 407
TH+ + +LE+ G + +V+QNVD LH ++G +K+ ELHG ++ +C KC
Sbjct: 94 THMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKC 144
>UniRef50_Q9I4L0 Cluster: NAD-dependent deacetylase 1; n=10;
Bacteria|Rep: NAD-dependent deacetylase 1 - Pseudomonas
aeruginosa
Length = 250
Score = 49.2 bits (112), Expect = 1e-04
Identities = 26/74 (35%), Positives = 38/74 (51%)
Frame = +3
Query: 186 SESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVI 365
++ A V G +R ++ N H I L + T +VTQNVD LH +AGS V+
Sbjct: 54 ADDPALVWGWYEWRRLKVLGVQPNPAHRAIAALSGRIANTRLVTQNVDDLHERAGSRDVL 113
Query: 366 ELHGTSYLVQCLKC 407
LHG+ + +C C
Sbjct: 114 HLHGSLHAPRCATC 127
>UniRef50_Q0CR31 Cluster: NAD-dependent histone deacetylase SIR2;
n=2; Pezizomycotina|Rep: NAD-dependent histone
deacetylase SIR2 - Aspergillus terreus (strain NIH 2624)
Length = 1068
Score = 48.8 bits (111), Expect = 1e-04
Identities = 22/55 (40%), Positives = 34/55 (61%), Gaps = 2/55 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEI 419
TH IR L+ KGK+ + TQN+D + AG EK+++ HG+ C+KC Y++
Sbjct: 248 THGFIRLLQDKGKLLTNYTQNIDNIEANAGVVPEKIVQCHGSFATATCVKCHYKV 302
Score = 34.3 bits (75), Expect = 2.9
Identities = 13/20 (65%), Positives = 17/20 (85%)
Frame = +1
Query: 94 SLGIPDYRSEDVGLYARSNH 153
SLGIPD+RS+D GLY++ H
Sbjct: 190 SLGIPDFRSKDTGLYSQLEH 209
>UniRef50_Q8Y015 Cluster: NAD-dependent deacetylase; n=11;
Bacteria|Rep: NAD-dependent deacetylase - Ralstonia
solanacearum (Pseudomonas solanacearum)
Length = 246
Score = 48.8 bits (111), Expect = 1e-04
Identities = 29/65 (44%), Positives = 35/65 (53%), Gaps = 4/65 (6%)
Frame = +3
Query: 225 RLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHG----TSYLV 392
R A + N HL I L + K ++VTQNVD LH +AGS VIELHG +L
Sbjct: 77 RRARVSQVQPNPAHLAIAALATR-KTVALVTQNVDGLHQRAGSVGVIELHGNLFANKWLD 135
Query: 393 QCLKC 407
C KC
Sbjct: 136 GCGKC 140
>UniRef50_Q8CJM9 Cluster: NAD-dependent deacetylase 2; n=3;
Actinomycetales|Rep: NAD-dependent deacetylase 2 -
Streptomyces coelicolor
Length = 241
Score = 48.8 bits (111), Expect = 1e-04
Identities = 23/53 (43%), Positives = 32/53 (60%), Gaps = 2/53 (3%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKC 407
N H + +LE++G ++TQNVD LH AG + KV+ELHGT+ C C
Sbjct: 71 NAAHRAVADLERRGVPVRVLTQNVDGLHQLAGVSARKVLELHGTARDCVCTGC 123
>UniRef50_Q4APN6 Cluster: Silent information regulator protein Sir2;
n=1; Chlorobium phaeobacteroides BS1|Rep: Silent
information regulator protein Sir2 - Chlorobium
phaeobacteroides BS1
Length = 217
Score = 48.4 bits (110), Expect = 2e-04
Identities = 25/71 (35%), Positives = 38/71 (53%)
Frame = +3
Query: 201 KVLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGT 380
KVLG R + C + H + L +VTQN+D +H +AGS+ VIELHG+
Sbjct: 44 KVLGFHEKRRKSVLDCQPHEGHSVVAVLPN----AKVVTQNIDGMHQRAGSKDVIELHGS 99
Query: 381 SYLVQCLKCPY 413
+ ++C C +
Sbjct: 100 LWRLRCQSCGF 110
>UniRef50_Q9VH08 Cluster: CG6284-PA; n=9; Eumetazoa|Rep: CG6284-PA -
Drosophila melanogaster (Fruit fly)
Length = 317
Score = 48.4 bits (110), Expect = 2e-04
Identities = 22/51 (43%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLKC 407
TH+ I L + G V +++QN+D LH K+G ++ + ELHG Y+ QC KC
Sbjct: 94 THMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKC 144
>UniRef50_Q839C6 Cluster: NAD-dependent deacetylase; n=14;
Bacilli|Rep: NAD-dependent deacetylase - Enterococcus
faecalis (Streptococcus faecalis)
Length = 237
Score = 48.4 bits (110), Expect = 2e-04
Identities = 34/86 (39%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Frame = +3
Query: 159 YTVSRICEVSE-SKAKVLGKKLYRLAEIQLCATNXTHLCIRELE--KKGKVTSIVTQNVD 329
Y +SR C +E K K LY + Q N H + +LE K+GK IV+QN+D
Sbjct: 51 YLLSRTCLKTEPEKFYQFVKTLYH-PDAQ---PNIIHQKMAQLEQMKRGK---IVSQNID 103
Query: 330 RLHHKAGSEKVIELHGTSYLVQCLKC 407
LH KAGS++V++ HG Y C C
Sbjct: 104 GLHRKAGSQEVVDFHGNLYECYCQTC 129
>UniRef50_UPI0000E49AD8 Cluster: PREDICTED: similar to NAD-dependent
deacetylase sirtuin 2 homolog; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to NAD-dependent
deacetylase sirtuin 2 homolog - Strongylocentrotus
purpuratus
Length = 400
Score = 48.0 bits (109), Expect = 2e-04
Identities = 46/144 (31%), Positives = 64/144 (44%), Gaps = 2/144 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
+H I L +KG + TQN+D L AG E ++E HG+ + CL C
Sbjct: 145 SHFFIHLLHEKGILLRHYTQNIDGLDRMAGVPDELIMEAHGSFHTGHCLNC--------- 195
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
E+ TE ES I D C K +E G +KPD+VFFG+++P
Sbjct: 196 NEMYTE-----ESMREKIMADLIPRCA----KCNE-------TGVVKPDVVFFGESLPPR 239
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTV 686
V + D + VMG+SL V
Sbjct: 240 FPTLVSEDFPQCDLLIVMGTSLVV 263
>UniRef50_Q9CBW6 Cluster: NAD-dependent deacetylase; n=14;
Mycobacterium|Rep: NAD-dependent deacetylase -
Mycobacterium leprae
Length = 237
Score = 48.0 bits (109), Expect = 2e-04
Identities = 32/100 (32%), Positives = 51/100 (51%), Gaps = 2/100 (2%)
Frame = +3
Query: 201 KVLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGT 380
+V G L+R + N H I +++ +V S++TQNVD LH +AGS V LHG+
Sbjct: 48 RVWGWYLWRHYLVANVKPNDGHRAIAAWQEQIEV-SVITQNVDDLHERAGSTPVHHLHGS 106
Query: 381 SYLVQCLKC--PYEIDRHELQEILTENNPDMESSFSMIRP 494
+ C +C Y ++ E + E +P + +IRP
Sbjct: 107 LFKFHCARCNVAYTGALPDMPEPVLEVDPPVCYCGGLIRP 146
>UniRef50_Q22KA8 Cluster: Transcriptional regulator, Sir2 family
protein; n=3; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 386
Score = 47.6 bits (108), Expect = 3e-04
Identities = 38/144 (26%), Positives = 66/144 (45%), Gaps = 2/144 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
+H+ + +L ++G + +++QN+D LH ++G + ELHG + L +CLKC + +
Sbjct: 96 SHMALVKLNQEGILKYLISQNIDGLHRRSGFNPNSLSELHGNTNLEKCLKC----GKSYM 151
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
++ D+ + + Q G L IV FG+N+PK
Sbjct: 152 RDYRVRKALDVHDHLT-----------------GRICDNQKCGGELVDTIVNFGENLPKK 194
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTV 686
+EQ +D V+GSSL V
Sbjct: 195 DMEQGFFNSKQADLHLVLGSSLRV 218
>UniRef50_Q7S6G9 Cluster: Putative uncharacterized protein
NCU04737.1; n=3; Sordariomycetes|Rep: Putative
uncharacterized protein NCU04737.1 - Neurospora crassa
Length = 670
Score = 47.6 bits (108), Expect = 3e-04
Identities = 21/55 (38%), Positives = 35/55 (63%), Gaps = 2/55 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEI 419
TH I L++KGK+ + +QN+D L KAG +K+++ HG+ C+KC Y++
Sbjct: 278 THAFIALLQQKGKLLTNYSQNIDNLEAKAGIHPDKLVQCHGSFATATCVKCGYKV 332
>UniRef50_Q6CAJ8 Cluster: Similar to sp|P53687 Saccharomyces
cerevisiae HST3 protein; n=1; Yarrowia lipolytica|Rep:
Similar to sp|P53687 Saccharomyces cerevisiae HST3
protein - Yarrowia lipolytica (Candida lipolytica)
Length = 385
Score = 47.6 bits (108), Expect = 3e-04
Identities = 39/168 (23%), Positives = 75/168 (44%), Gaps = 17/168 (10%)
Frame = +3
Query: 234 EIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHK--AGSEKVIELHGTSYLVQCLKC 407
+ Q H + +L+ GK+ S TQN+D L HK ++K+++LHG + C++C
Sbjct: 101 QCQASRPTRVHEFVAKLDTAGKLLSCYTQNIDSLEHKTEVSAKKIVQLHGHLDTLNCIQC 160
Query: 408 PYEID-RHELQEILTENNPD---MESSFSMIRPD------GDVDCRGNK*KNSELHSAQS 557
++ + ++E E N D +E + S+ C ++
Sbjct: 161 SEKLQWKDRVKEKKKEENNDDSGLEENESVSDDSTRRHMIACPTCEARALARELNGRRRT 220
Query: 558 VKGPLKPDIVFFGDNVPKYRVEQVRKXVTSS-----DAVFVMGSSLTV 686
G ++P++V +G+ P E++ +T D + V+G+SL V
Sbjct: 221 AVGWMRPNVVLYGE--PHPEAEEIGSRITRDLKKRPDCLVVIGTSLAV 266
>UniRef50_Q7ZVK3 Cluster: NAD-dependent deacetylase sirtuin-2; n=12;
Coelomata|Rep: NAD-dependent deacetylase sirtuin-2 -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 379
Score = 47.6 bits (108), Expect = 3e-04
Identities = 40/143 (27%), Positives = 63/143 (44%), Gaps = 2/143 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H I+ L+ KG + +QN+D L AG E +IE HGT + C+
Sbjct: 147 HYFIKMLKDKGLLRRCYSQNIDTLERVAGLEGEDLIEAHGTFHTSHCV------------ 194
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYR 617
SF + R + +D N+ + E+ S +KPDIVFFG+++P
Sbjct: 195 ------------SF-LCRKEYSMDWMKNQIFSEEIPKCDSCGSLVKPDIVFFGESLPSRF 241
Query: 618 VEQVRKXVTSSDAVFVMGSSLTV 686
++ D + +MG+SL V
Sbjct: 242 FTSMKADFPQCDLLIIMGTSLQV 264
>UniRef50_UPI0000499DEA Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 383
Score = 47.2 bits (107), Expect = 4e-04
Identities = 40/144 (27%), Positives = 62/144 (43%), Gaps = 2/144 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H ++ L KG + + TQN+D L AG ++KVI HGT CL C H+
Sbjct: 209 HRFLKLLNDKGILKMVYTQNIDGLESVAGIPNDKVICSHGTFRSSHCLSC------HK-- 260
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYR 617
PD I+ + C + G +KPDIVFF +++P
Sbjct: 261 -----KYPDTSVFIESIKKGEIIHC--------------NCGGLIKPDIVFFNESLPDEF 301
Query: 618 VEQVRKXVTSSDAVFVMGSSLTVY 689
E ++ D + ++G++L VY
Sbjct: 302 FESIKDKFDDCDMLLIIGTALVVY 325
>UniRef50_A1CD03 Cluster: SIR2 family histone deacetylase, putative;
n=2; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Aspergillus clavatus
Length = 329
Score = 47.2 bits (107), Expect = 4e-04
Identities = 42/145 (28%), Positives = 61/145 (42%), Gaps = 3/145 (2%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH + L KK + + TQN+D L G K++ HG+ C KC +
Sbjct: 88 THAFLALLAKKNLLHFLFTQNIDGLERDTGVPENKILNAHGSWRTQHCWKCKTSYPDDLM 147
Query: 435 QEILTENNPDMESSFSMIRPDGDV-DCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPK 611
+E + + + P V DC G P+KPD+VFFG ++P
Sbjct: 148 KEAIAKG----------VVPYCQVPDCGG----------------PIKPDVVFFGQSLPA 181
Query: 612 YRVEQVRKXVTSSDAVFVMGSSLTV 686
E K V +D + VMG+SL V
Sbjct: 182 -EFEDEEKKVPEADLMIVMGTSLKV 205
>UniRef50_Q96EB6 Cluster: NAD-dependent deacetylase sirtuin-1; n=29;
Euteleostomi|Rep: NAD-dependent deacetylase sirtuin-1 -
Homo sapiens (Human)
Length = 747
Score = 47.2 bits (107), Expect = 4e-04
Identities = 20/53 (37%), Positives = 31/53 (58%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEID 422
H I +K+GK+ TQN+D L AG +++I+ HG+ CL C Y++D
Sbjct: 327 HKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVD 379
Score = 35.5 bits (78), Expect = 1.3
Identities = 16/39 (41%), Positives = 25/39 (64%)
Frame = +3
Query: 570 LKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
+KP+IVFFG+N+P+ ++ D + V+GSSL V
Sbjct: 407 MKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKV 445
>UniRef50_A2F8N6 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 320
Score = 34.7 bits (76), Expect(2) = 4e-04
Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 3/81 (3%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H + E G + +QN+D L AG E ++E HGT C KC + +++
Sbjct: 109 HFLAKLFENHGILLRHYSQNIDGLDKAAGLSEEHLVEWHGTLSKATCRKCSKKYTLDDIK 168
Query: 438 -EILTENNPDMESSFSMIRPD 497
+IL E P S +I+PD
Sbjct: 169 PKILAEAVPRC-SCGGVIQPD 188
Score = 31.9 bits (69), Expect(2) = 4e-04
Identities = 15/44 (34%), Positives = 25/44 (56%)
Frame = +3
Query: 555 SVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
S G ++PD++ +GD + K V +D +FV+G+SL V
Sbjct: 180 SCGGVIQPDVMLYGDYNDDDLYTHLDKDVEQADLLFVLGTSLKV 223
>UniRef50_A7H7B6 Cluster: Silent information regulator protein Sir2;
n=2; Anaeromyxobacter|Rep: Silent information regulator
protein Sir2 - Anaeromyxobacter sp. Fw109-5
Length = 270
Score = 46.8 bits (106), Expect = 5e-04
Identities = 23/61 (37%), Positives = 37/61 (60%), Gaps = 1/61 (1%)
Frame = +3
Query: 219 LYRLAEIQLCATNXTHLCIRELEKK-GKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQ 395
L+R + N H + LE+ G+ ++VTQN+D LH +AGSE+V+ +HG + V+
Sbjct: 73 LHRFGVCRDARPNAGHAALVALERALGERFTLVTQNIDGLHRRAGSERVLCIHGDAAYVR 132
Query: 396 C 398
C
Sbjct: 133 C 133
>UniRef50_Q4P3S4 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 400
Score = 46.8 bits (106), Expect = 5e-04
Identities = 25/73 (34%), Positives = 37/73 (50%), Gaps = 8/73 (10%)
Frame = +3
Query: 237 IQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKA------GSEKVIELHGTSYLVQC 398
+++ N H I +++ G V +TQNVD LHH A + ++ELHGT V C
Sbjct: 102 VRVAQANKGHYSIAAIQRLGYVPEYITQNVDNLHHAATPSASLAASTILELHGTLKHVVC 161
Query: 399 LKCP--YEIDRHE 431
+ P Y D H+
Sbjct: 162 VSSPEGYRKDEHK 174
Score = 46.0 bits (104), Expect = 9e-04
Identities = 21/69 (30%), Positives = 39/69 (56%)
Frame = +3
Query: 492 PDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMG 671
PDGDV+ + + G LKP ++FFG++VP + + V +++A+ ++G
Sbjct: 252 PDGDVELHNVDYSTFNYPACPNCGGVLKPAVIFFGESVPDKLRDHSYEMVENANAMLLIG 311
Query: 672 SSLTVYSSY 698
+SL YS++
Sbjct: 312 TSLATYSAF 320
Score = 38.3 bits (85), Expect = 0.18
Identities = 22/63 (34%), Positives = 33/63 (52%), Gaps = 5/63 (7%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFV----KYPKVRQRYWARNYIGWPRFSCVQPT-SH 264
GI YR E+ +++PI Y EFV K RQRY++R+++G+P Q H
Sbjct: 52 GIAPYRGENGHYTIHKHYRPIFYHEFVDASDKGHLARQRYFSRSFLGFPTVRVAQANKGH 111
Query: 265 ISV 273
S+
Sbjct: 112 YSI 114
>UniRef50_A1ZZG3 Cluster: NAD-dependent deacetylase; n=35;
Bacteria|Rep: NAD-dependent deacetylase - Microscilla
marina ATCC 23134
Length = 245
Score = 46.4 bits (105), Expect = 7e-04
Identities = 22/41 (53%), Positives = 27/41 (65%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHG 377
N HL + LE K +V I+TQN+D LH KAGS V+ LHG
Sbjct: 81 NEGHLALARLEAKYEVV-IITQNIDDLHEKAGSSNVLHLHG 120
>UniRef50_Q046W9 Cluster: NAD-dependent protein deacetylase, SIR2
family; n=6; Lactobacillus|Rep: NAD-dependent protein
deacetylase, SIR2 family - Lactobacillus gasseri (strain
ATCC 33323 / DSM 20243)
Length = 237
Score = 46.0 bits (104), Expect = 9e-04
Identities = 20/45 (44%), Positives = 29/45 (64%)
Frame = +3
Query: 306 SIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQE 440
+++TQNVD L KAG++ VIE HG Y + C KC +I E ++
Sbjct: 98 TLITQNVDGLDKKAGNKHVIEFHGNLYNIFCTKCHEKISYEEYKK 142
>UniRef50_Q23E36 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 1348
Score = 46.0 bits (104), Expect = 9e-04
Identities = 35/143 (24%), Positives = 70/143 (48%), Gaps = 2/143 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H + E+ ++ ++ + +QNVD L +AG EK+ ++HG +C KC + +H++
Sbjct: 92 HYFMAEVNRREQLLFVFSQNVDGLELEAGLPPEKLCQVHGNYRGARCQKCGF---KHDIN 148
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYR 617
+ ++ C K +GP++P++VFFG+++ K
Sbjct: 149 KYK-----------EFVQKQVIYKCENCK------------RGPVRPNVVFFGESLDKGF 185
Query: 618 VEQVRKXVTSSDAVFVMGSSLTV 686
+ K + ++D VF+MG+S+ V
Sbjct: 186 TKNTYK-IAAADCVFIMGTSMQV 207
>UniRef50_Q9USN7 Cluster: Sir2 family histone deacetylase Hst2; n=1;
Schizosaccharomyces pombe|Rep: Sir2 family histone
deacetylase Hst2 - Schizosaccharomyces pombe (Fission
yeast)
Length = 332
Score = 46.0 bits (104), Expect = 9e-04
Identities = 44/145 (30%), Positives = 65/145 (44%), Gaps = 2/145 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH IR L K + TQN+D L AG + +IE HG+ +C++C +E+
Sbjct: 99 THYFIRLLHDKRLLQKCYTQNIDTLERLAGVPDKALIEAHGSFQYSRCIEC------YEM 152
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKY 614
E TE +R C K ++ S KG +KP IVF+G+ +P
Sbjct: 153 AE--TE----------YVRA-----CIMQK----QVPKCNSCKGLIKPMIVFYGEGLPMR 191
Query: 615 RVEQVRKXVTSSDAVFVMGSSLTVY 689
E + K D V+G+SL V+
Sbjct: 192 FFEHMEKDTKVCDMALVIGTSLLVH 216
>UniRef50_Q0UNC9 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 479
Score = 46.0 bits (104), Expect = 9e-04
Identities = 44/147 (29%), Positives = 66/147 (44%), Gaps = 5/147 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH IR L+ K K+ + TQN+D + AG +K+I+ HG+ C E+ L
Sbjct: 245 THEFIRLLQDKEKLLTNYTQNIDNVEANAGILKDKLIQCHGSWATATC----REMQTQPL 300
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGP--LKPDIVFFGDNVP 608
+ T N S + D D SE A + P +KPDI FFG+ +P
Sbjct: 301 KRKRTSN-----GSGPRKKKSSDED--------SESDGAYDIPQPGIMKPDITFFGEALP 347
Query: 609 KYRVEQVRKXVTSS-DAVFVMGSSLTV 686
++++ D V VMG+S+ V
Sbjct: 348 NNFFDRLKDVDKDKVDLVIVMGTSMKV 374
>UniRef50_O59923 Cluster: NAD-dependent histone deacetylase SIR2;
n=3; Candida albicans|Rep: NAD-dependent histone
deacetylase SIR2 - Candida albicans (Yeast)
Length = 515
Score = 46.0 bits (104), Expect = 9e-04
Identities = 46/164 (28%), Positives = 75/164 (45%), Gaps = 5/164 (3%)
Frame = +3
Query: 210 GKKLYRLAEIQLCAT---NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELH 374
G+ Y +A + L + H ++ L+ K K+ TQN+D L +AG SEK+++ H
Sbjct: 285 GRLFYTIAHLVLPPDGKFSLLHAFLKLLQDKHKLLRNYTQNIDNLEQRAGLKSEKLVQCH 344
Query: 375 GTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQ 554
G+ +C+ C Q I E ++ IR C KN++ A
Sbjct: 345 GSFAKAKCVSC---------QGIFAG-----EKIYNHIRRKQVPRC-AICWKNTK--QAP 387
Query: 555 SVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
G +KP I FFG+++P+ + K + D V+G+SL V
Sbjct: 388 IHFGAIKPTITFFGEDLPERFHTLMDKDLQQIDLFLVIGTSLKV 431
>UniRef50_UPI00006CA40C Cluster: transcriptional regulator, Sir2
family protein; n=1; Tetrahymena thermophila SB210|Rep:
transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 471
Score = 45.6 bits (103), Expect = 0.001
Identities = 23/64 (35%), Positives = 41/64 (64%), Gaps = 1/64 (1%)
Frame = +3
Query: 501 DVDCRGNK*KNSEL-HSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSS 677
D++ KN ++ + + +G +KPDIVFFG+++P+ +Q+ + +D VFVMG+S
Sbjct: 338 DIELFNEAVKNDKICYCKECEEGIVKPDIVFFGESLPQSFFQQI-DSLNKADLVFVMGTS 396
Query: 678 LTVY 689
L V+
Sbjct: 397 LKVF 400
>UniRef50_Q3E2I1 Cluster: Silent information regulator protein Sir2;
n=7; Bacteria|Rep: Silent information regulator protein
Sir2 - Chloroflexus aurantiacus J-10-fl
Length = 254
Score = 45.6 bits (103), Expect = 0.001
Identities = 22/61 (36%), Positives = 33/61 (54%), Gaps = 2/61 (3%)
Frame = +3
Query: 222 YRLAEIQLCAT--NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQ 395
Y ++ C N H + +L ++VTQN+D LH +AGS +VIELHG + +
Sbjct: 71 YAERRVKACTAQPNPAHHALADLATLVPRLTLVTQNIDGLHQRAGSPQVIELHGNIHRAR 130
Query: 396 C 398
C
Sbjct: 131 C 131
>UniRef50_Q6C8V5 Cluster: Similar to tr|Q9FY91 Arabidopsis thaliana
SIR2-family protein; n=1; Yarrowia lipolytica|Rep:
Similar to tr|Q9FY91 Arabidopsis thaliana SIR2-family
protein - Yarrowia lipolytica (Candida lipolytica)
Length = 411
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/44 (43%), Positives = 25/44 (56%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGW 231
G+PDYR NH+P Y EFV R+RYW+R +IG+
Sbjct: 63 GLPDYRGPTGTYTTNPNHQPTLYHEFVSDEHKRKRYWSRAWIGY 106
Score = 45.6 bits (103), Expect = 0.001
Identities = 20/45 (44%), Positives = 32/45 (71%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
G LKP IVFFG++VP+ + R + SSD + V+G+SL+ +S++
Sbjct: 320 GVLKPSIVFFGESVPEADRARARDLLESSDQLLVIGTSLSTFSAF 364
Score = 37.9 bits (84), Expect = 0.24
Identities = 25/89 (28%), Positives = 42/89 (47%), Gaps = 21/89 (23%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHH-------------------KAGSE--KVIEL 371
N H + + G ++ ++TQNVD LH +AG E ++EL
Sbjct: 116 NVAHEVLTGWLRGGHISGLITQNVDGLHKLSQVSGGDIVDNVNVSADLRAGREVPALVEL 175
Query: 372 HGTSYLVQCLKCPYEIDRHELQEILTENN 458
HG++Y V CL C + R + Q+ + ++N
Sbjct: 176 HGSAYRVHCLSCGDQTSREDFQDRMAKDN 204
>UniRef50_Q6MJJ2 Cluster: NAD-dependent deacetylase; n=5;
Proteobacteria|Rep: NAD-dependent deacetylase -
Bdellovibrio bacteriovorus
Length = 235
Score = 45.6 bits (103), Expect = 0.001
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 5/72 (6%)
Frame = +3
Query: 207 LGKKLYRLAEIQL----CATNXTHLCIRELEKKGKVTSI-VTQNVDRLHHKAGSEKVIEL 371
L ++ Y L QL A N H + +LE + + VTQNVD LH +AGS+ ++ +
Sbjct: 53 LVQRFYNLRRAQLRDPNLAPNPAHQALVDLENLWEGNFLLVTQNVDNLHRRAGSKNLLHM 112
Query: 372 HGTSYLVQCLKC 407
HG V CL C
Sbjct: 113 HGRLDRVFCLHC 124
>UniRef50_Q1D737 Cluster: NAD-dependent deacetylase; n=1; Myxococcus
xanthus DK 1622|Rep: NAD-dependent deacetylase -
Myxococcus xanthus (strain DK 1622)
Length = 245
Score = 45.2 bits (102), Expect = 0.002
Identities = 16/33 (48%), Positives = 25/33 (75%)
Frame = +3
Query: 309 IVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKC 407
+ TQNVD LH +AGS++V+E+HG + +C +C
Sbjct: 93 LATQNVDGLHTRAGSQRVVEMHGNLFKTRCSRC 125
>UniRef50_Q0LN22 Cluster: Silent information regulator protein Sir2;
n=1; Herpetosiphon aurantiacus ATCC 23779|Rep: Silent
information regulator protein Sir2 - Herpetosiphon
aurantiacus ATCC 23779
Length = 243
Score = 44.4 bits (100), Expect = 0.003
Identities = 18/42 (42%), Positives = 27/42 (64%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGT 380
N H + +LE+ G + TQN+D LH +AGS +V E+HG+
Sbjct: 82 NAGHYALAQLEQLGTQFKLFTQNIDSLHQRAGSSQVYEVHGS 123
Score = 33.9 bits (74), Expect = 3.9
Identities = 17/52 (32%), Positives = 28/52 (53%)
Frame = +3
Query: 531 NSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
N+E + PL+PDIV+FG+ + ++ + SSD V+G+S V
Sbjct: 140 NAEQPICPACGAPLRPDIVWFGELLDAGILQAAKAAFDSSDVALVIGTSAIV 191
>UniRef50_Q175I4 Cluster: Chromatin regulatory protein sir2; n=3;
Coelomata|Rep: Chromatin regulatory protein sir2 - Aedes
aegypti (Yellowfever mosquito)
Length = 720
Score = 44.4 bits (100), Expect = 0.003
Identities = 19/65 (29%), Positives = 36/65 (55%), Gaps = 2/65 (3%)
Frame = +3
Query: 234 EIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLKC 407
++ L TH+ + EL ++G + +V+QN D LH ++G + + E+HG Y+ C C
Sbjct: 120 DLSLADPTYTHMALSELHRRGILKHVVSQNCDGLHLRSGLPRFCLSEVHGNMYVEVCKNC 179
Query: 408 PYEID 422
++
Sbjct: 180 KPNVE 184
>UniRef50_A6XDL2 Cluster: Sirtuin 1; n=2; Schistosoma|Rep: Sirtuin 1
- Schistosoma mansoni (Blood fluke)
Length = 568
Score = 44.4 bits (100), Expect = 0.003
Identities = 23/68 (33%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQE 440
TH I LE K K+ TQN+D L AG ++I+ HG+ C C ++ ++E
Sbjct: 227 THRMIALLESKDKLLRNYTQNIDTLEQAAGITRLIQCHGSFASATCTNCKLKVSSDFIKE 286
Query: 441 -ILTENNP 461
I T++ P
Sbjct: 287 AIFTQSIP 294
Score = 41.1 bits (92), Expect = 0.025
Identities = 27/91 (29%), Positives = 40/91 (43%)
Frame = +3
Query: 414 EIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFF 593
E H E NP+ +S + + D + + S A G LKPDIVFF
Sbjct: 318 ESTNHSSDLSTVEENPNNNNSNNNMSVDTSPKVKSKRTNKSRRRLASY--GVLKPDIVFF 375
Query: 594 GDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
G+ + + + + +D V V+GSSL V
Sbjct: 376 GEGLSNEFHDSLSNDIKQTDLVLVIGSSLKV 406
>UniRef50_Q5KA61 Cluster: Histone deacetylase, putative; n=1;
Filobasidiella neoformans|Rep: Histone deacetylase,
putative - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 596
Score = 44.4 bits (100), Expect = 0.003
Identities = 21/67 (31%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQE- 440
H I+ LE +G + TQN+D L AG E+V++ HG+ CL+C + ++
Sbjct: 231 HRWIKMLEDRGVLLRNYTQNIDTLESLAGVERVLQCHGSFKTASCLRCKQRVPGRTIEPY 290
Query: 441 ILTENNP 461
I+++ P
Sbjct: 291 IMSQQIP 297
>UniRef50_O94066 Cluster: Transcription regulatory protein; n=6;
Saccharomycetales|Rep: Transcription regulatory protein
- Candida albicans (Yeast)
Length = 331
Score = 44.4 bits (100), Expect = 0.003
Identities = 47/165 (28%), Positives = 74/165 (44%), Gaps = 6/165 (3%)
Frame = +3
Query: 213 KKLYRLAEIQLCATNXT----HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEK--VIELH 374
K Y LAE +L N H I+ L+ +G + + TQN+D L AG E ++E H
Sbjct: 71 KPFYTLAE-ELYPGNFAPTKFHHFIKLLQDQGSLKRVYTQNIDTLERLAGVEDKYIVEAH 129
Query: 375 GTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQ 554
G+ C +D H+ E+ TE +++ K+ ++ S Q
Sbjct: 130 GSFASNHC------VDCHK--EMTTET---LKTYM----------------KDKKIPSCQ 162
Query: 555 SVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
+G +KPDIVFFG+ +P + + V G+SLTV+
Sbjct: 163 HCEGYVKPDIVFFGEGLPVKFFDLWEDDCEDVEVAIVAGTSLTVF 207
>UniRef50_Q1RL71 Cluster: Zinc finger protein; n=2; Ciona
intestinalis|Rep: Zinc finger protein - Ciona
intestinalis (Transparent sea squirt)
Length = 523
Score = 44.0 bits (99), Expect = 0.004
Identities = 25/69 (36%), Positives = 35/69 (50%), Gaps = 2/69 (2%)
Frame = +3
Query: 207 LGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGT 380
L K+LY + + N H +R L +KG + + TQN+D L AG K++E HGT
Sbjct: 177 LAKELYPSGKYR---PNIVHYFVRCLHEKGLLLRMYTQNIDGLERLAGIPPSKLVEAHGT 233
Query: 381 SYLVQCLKC 407
C KC
Sbjct: 234 FSTASCTKC 242
Score = 39.1 bits (87), Expect = 0.10
Identities = 20/41 (48%), Positives = 26/41 (63%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
G +KPDIVFFG+++PK R K S D + V G+SL V
Sbjct: 271 GTIKPDIVFFGEDLPK-RFYYYLKDFPSCDLLLVFGTSLQV 310
>UniRef50_Q6CQA7 Cluster: Kluyveromyces lactis strain NRRL Y-1140
chromosome D of strain NRRL Y- 1140 of Kluyveromyces
lactis; n=1; Kluyveromyces lactis|Rep: Kluyveromyces
lactis strain NRRL Y-1140 chromosome D of strain NRRL Y-
1140 of Kluyveromyces lactis - Kluyveromyces lactis
(Yeast) (Candida sphaerica)
Length = 399
Score = 44.0 bits (99), Expect = 0.004
Identities = 41/161 (25%), Positives = 80/161 (49%), Gaps = 14/161 (8%)
Frame = +3
Query: 246 CATNXT--HLCIRELEKKGKVTSIVTQNVDRLHHK----AGSE-----KVIELHGTSYLV 392
C + T H I +L +K +V I +QN+D L K + +E +V++LHG+ + +
Sbjct: 183 CTSKPTAYHSFINQLCEKNQVKRIYSQNIDGLETKFQTTSANESPKNPQVVQLHGSIHHM 242
Query: 393 QCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPL 572
C+KC ++++ + + + D E+ I P +C+ + S G L
Sbjct: 243 SCMKCR---KKYDMDPSMFKTDEDAET--GEIVPQCP-ECKEFESVRSVCGKRLQGVGRL 296
Query: 573 KPDIVFFGDNVPKYRV--EQVRKXVTSS-DAVFVMGSSLTV 686
KP +V + + P+ + E + K + S+ DA+ ++G+SL +
Sbjct: 297 KPSVVLYNEYHPEGDIISEMMNKDLKSNPDALLIVGTSLKI 337
>UniRef50_A1ZPG8 Cluster: NAD-dependent deacetylase; n=1;
Microscilla marina ATCC 23134|Rep: NAD-dependent
deacetylase - Microscilla marina ATCC 23134
Length = 278
Score = 43.6 bits (98), Expect = 0.005
Identities = 27/73 (36%), Positives = 38/73 (52%), Gaps = 3/73 (4%)
Frame = +3
Query: 189 ESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKK-GKVTSIVTQNVDRLHHKAGS--EK 359
E+ A+V LYR + N HL + E ++TQN+DRLH KAG+ K
Sbjct: 66 ENPAEVWKFVLYRKVSFRDLQPNAGHLALASTEVLLPNNFRLITQNIDRLHIKAGNTQAK 125
Query: 360 VIELHGTSYLVQC 398
V+E+HG V+C
Sbjct: 126 VLEIHGNMETVRC 138
>UniRef50_A2GAR7 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 312
Score = 43.6 bits (98), Expect = 0.005
Identities = 36/136 (26%), Positives = 65/136 (47%), Gaps = 2/136 (1%)
Frame = +3
Query: 285 EKKGKVTSIVTQNVDRLHHKAGS--EKVIELHGTSYLVQCLKCPYEIDRHELQEILTENN 458
+K +T + TQN+D L AG +K++E HG+ + C KC + + + +E
Sbjct: 113 DKHKLLTRLYTQNIDSLDISAGLPLDKIVEAHGSFTYLTCRKCGSKFEFADYKE------ 166
Query: 459 PDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKX 638
E + V CR K +G +KPD+VF+G+++P+
Sbjct: 167 ---EFQTGKV-----VHCRECK------------EGVIKPDVVFYGEDLPQRFHHLSEND 206
Query: 639 VTSSDAVFVMGSSLTV 686
++++ + +MG+SLTV
Sbjct: 207 FSTANLLIIMGTSLTV 222
>UniRef50_Q9I4E1 Cluster: NAD-dependent deacetylase 2; n=6;
Pseudomonadaceae|Rep: NAD-dependent deacetylase 2 -
Pseudomonas aeruginosa
Length = 256
Score = 43.6 bits (98), Expect = 0.005
Identities = 27/71 (38%), Positives = 37/71 (52%), Gaps = 3/71 (4%)
Frame = +3
Query: 213 KKLYRLAEIQLCAT-NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGS--EKVIELHGTS 383
K L L + L A N H I EL+K ++TQN+D H +AGS E++IE+HG
Sbjct: 72 KYLAELGKACLAARPNAGHEAIAELQKHKPECWVLTQNIDGFHRQAGSPAERLIEIHGEL 131
Query: 384 YLVQCLKCPYE 416
+ C C E
Sbjct: 132 APLYCQSCGAE 142
>UniRef50_A0C2R2 Cluster: Chromosome undetermined scaffold_145,
whole genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_145,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 258
Score = 43.2 bits (97), Expect = 0.006
Identities = 20/51 (39%), Positives = 33/51 (64%)
Frame = +3
Query: 534 SELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
SE+ G +KPD+VFFG ++P+ E++ + ++ SD V +MG+SL V
Sbjct: 157 SEIMKCTDCNGLIKPDVVFFGQSLPQLYFEKLPE-ISLSDLVIIMGTSLQV 206
Score = 34.3 bits (75), Expect = 2.9
Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 2/50 (4%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKC 407
H I L++ ++ + TQN+D L AG KVI++HG C+ C
Sbjct: 92 HQFIYHLDRNDQLLNCFTQNIDGLELVAGVRESKVIQVHGHRRTASCIDC 141
>UniRef50_A3LRA1 Cluster: Transcriptional regulatory protein; n=2;
Saccharomycetales|Rep: Transcriptional regulatory
protein - Pichia stipitis (Yeast)
Length = 311
Score = 42.7 bits (96), Expect = 0.008
Identities = 43/151 (28%), Positives = 71/151 (47%), Gaps = 25/151 (16%)
Frame = +3
Query: 312 VTQNVDRLHHKAG--SEKVIELHGTSYLVQCLK--CPYEIDRHELQEILTE--------- 452
+TQNVD L ++G E + E+HG+ + + C C Y +DR+ L+ LT+
Sbjct: 105 ITQNVDGLSSRSGHAKENLYEIHGSLFNLNCTSFMCNY-VDRNNLKHPLTKALEGTEYEY 163
Query: 453 ----NNPDMESSFSMIRPDGDVDCRGNK*KN---SELHSAQSVKGP--LKPDIVFFGDNV 605
+E S + D + + KN SEL K L+P +V+FG+++
Sbjct: 164 DRKNRKRSLEEDDSSHQVDYSISPQFRPVKNIPESELPQCPVCKDGSLLRPGVVWFGESL 223
Query: 606 PKYRVEQVRKXVTSS---DAVFVMGSSLTVY 689
P + V + S+ D + V+G+S TVY
Sbjct: 224 PLNVMNSVDNFIESNNSVDLILVIGTSGTVY 254
>UniRef50_A2DKF0 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 347
Score = 42.3 bits (95), Expect = 0.011
Identities = 23/64 (35%), Positives = 33/64 (51%)
Frame = +3
Query: 249 ATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRH 428
A + TH I ELE GK+ + +QNVD L K+ +HG+ CL C + D
Sbjct: 134 AHSDTHYFIAELENHGKLQRLYSQNVDTLECGVPESKLRCVHGSWRNSYCLSCGKKFDIE 193
Query: 429 ELQE 440
+L+E
Sbjct: 194 DLRE 197
>UniRef50_Q875P9 Cluster: HST1; n=1; Lachancea kluyveri|Rep: HST1 -
Saccharomyces kluyveri (Yeast) (Saccharomyces
silvestris)
Length = 414
Score = 42.3 bits (95), Expect = 0.011
Identities = 19/54 (35%), Positives = 32/54 (59%), Gaps = 2/54 (3%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEI 419
H IR ++ KGK+ TQN+D L AG +EK+++ HG+ C+ C +++
Sbjct: 155 HSFIRMIQDKGKLLRNYTQNIDNLESYAGIQAEKMVQCHGSFATASCVTCHWKL 208
Score = 38.7 bits (86), Expect = 0.14
Identities = 21/52 (40%), Positives = 29/52 (55%)
Frame = +3
Query: 531 NSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
NS H +S G LKPDI FFG+ +P +R+ V D + +G+SL V
Sbjct: 283 NSVFHMMKSY-GVLKPDITFFGEALPSKFHRFIREDVLKCDLLICIGTSLKV 333
>UniRef50_A6G0H3 Cluster: Silent information regulator protein Sir2;
n=1; Plesiocystis pacifica SIR-1|Rep: Silent information
regulator protein Sir2 - Plesiocystis pacifica SIR-1
Length = 288
Score = 41.9 bits (94), Expect = 0.015
Identities = 26/61 (42%), Positives = 35/61 (57%), Gaps = 4/61 (6%)
Frame = +3
Query: 219 LYRLAEIQLCATNXTHLCIRELEKK-GKVTSIVTQNVDRLHHKAGS--EKVIELHG-TSY 386
LYR A N H + LE+ G+ +VTQNVD LH +AG+ E+ IE+HG T Y
Sbjct: 85 LYRKGVCNAAAPNPAHEALVRLEQALGERFCLVTQNVDGLHLRAGNSRERTIEVHGNTDY 144
Query: 387 L 389
+
Sbjct: 145 M 145
>UniRef50_A2DZ01 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 281
Score = 41.9 bits (94), Expect = 0.015
Identities = 30/82 (36%), Positives = 46/82 (56%), Gaps = 5/82 (6%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGS--EKVIELHG--TSYLVQCLKCPYEIDRHE 431
H + ++ G V+ ++TQN D LH EKV+ELHG T Y V C KC +E+ +
Sbjct: 109 HNVLHQMVIDGYVSDLLTQNCDSLHSYDDEYDEKVVELHGAATDYGV-CEKC-HELRNVD 166
Query: 432 LQEIL-TENNPDMESSFSMIRP 494
+ EIL T+ +P S+++P
Sbjct: 167 VLEILHTDTSPVCNVCGSVLKP 188
>UniRef50_Q9NRC8 Cluster: NAD-dependent deacetylase sirtuin-7; n=24;
Eumetazoa|Rep: NAD-dependent deacetylase sirtuin-7 -
Homo sapiens (Human)
Length = 400
Score = 41.9 bits (94), Expect = 0.015
Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 2/61 (3%)
Frame = +3
Query: 231 AEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLK 404
A++ TH+ I L ++ V +V+QN D LH ++G + + ELHG Y+ C
Sbjct: 138 ADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTS 197
Query: 405 C 407
C
Sbjct: 198 C 198
>UniRef50_Q3V7G9 Cluster: Putative cobalamin biosynthetic protein;
n=2; Acinetobacter|Rep: Putative cobalamin biosynthetic
protein - Acinetobacter sp. (strain ADP1)
Length = 233
Score = 41.5 bits (93), Expect = 0.019
Identities = 22/57 (38%), Positives = 30/57 (52%)
Frame = +3
Query: 225 RLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQ 395
R I N H I +LE +V ++TQN+D LH +AGS V+ LHG L +
Sbjct: 56 RRKNILAAQPNLAHQIIAQLESCYQV-QVITQNIDDLHERAGSTHVLHLHGNIRLAK 111
Score = 35.5 bits (78), Expect = 1.3
Identities = 16/41 (39%), Positives = 26/41 (63%)
Frame = +3
Query: 567 PLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
PL+P +V+FG+ VP Y + + +D V+GS+L+VY
Sbjct: 143 PLRPHVVWFGEAVPAY--DDAIAMLKDADVFIVIGSTLSVY 181
>UniRef50_A5USR3 Cluster: Silent information regulator protein Sir2;
n=3; Chloroflexi (class)|Rep: Silent information
regulator protein Sir2 - Roseiflexus sp. RS-1
Length = 259
Score = 41.5 bits (93), Expect = 0.019
Identities = 19/61 (31%), Positives = 34/61 (55%)
Frame = +3
Query: 222 YRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCL 401
YR + TH + +LE+ +++TQ++D LH +AGS +IEL+G+ +C
Sbjct: 71 YRRMLAERAQPGVTHYALVDLEQHYPAFTLITQSIDGLHWRAGSRDLIELNGSLRRCRCF 130
Query: 402 K 404
+
Sbjct: 131 E 131
>UniRef50_A7AWG1 Cluster: Transcriptional regulator, Sir2 family
domain containing protein; n=2; Babesia bovis|Rep:
Transcriptional regulator, Sir2 family domain containing
protein - Babesia bovis
Length = 656
Score = 41.5 bits (93), Expect = 0.019
Identities = 18/50 (36%), Positives = 31/50 (62%), Gaps = 2/50 (4%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSE--KVIELHGTSYLVQCLKC 407
HL L + G + +++TQN+D LH +G + + IELHG ++ +C+ C
Sbjct: 125 HLATLALLRAGYIRTVITQNIDGLHAISGMKHSECIELHGNVFIERCIFC 174
>UniRef50_A4RCT8 Cluster: Putative uncharacterized protein; n=3;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 1040
Score = 41.1 bits (92), Expect = 0.025
Identities = 21/61 (34%), Positives = 35/61 (57%), Gaps = 2/61 (3%)
Frame = +3
Query: 222 YRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQ 395
YR E N H + EL +K +++TQNVD L +AG +++++ELHG + ++
Sbjct: 87 YRREEALKAQPNKAHRALAELARKVPGFTMLTQNVDNLSPRAGHPADQLLELHGNLFDLK 146
Query: 396 C 398
C
Sbjct: 147 C 147
>UniRef50_Q55DB0 Cluster: NAD(+)-dependent deacetylase, silent
information regulator protein (Sir2) family protein;
n=1; Dictyostelium discoideum AX4|Rep: NAD(+)-dependent
deacetylase, silent information regulator protein (Sir2)
family protein - Dictyostelium discoideum AX4
Length = 346
Score = 40.7 bits (91), Expect = 0.034
Identities = 43/152 (28%), Positives = 71/152 (46%), Gaps = 8/152 (5%)
Frame = +3
Query: 255 NXTHLCIRE-LEKKGKVTSIVTQNVDRLHHKA--GSEKVIELHGTSYLVQCLK--CPYEI 419
N HL I +E G ++++TQNVD LH KA EK++E+HG L +C+ C +E
Sbjct: 112 NSGHLAISNFVEYLG--SNVITQNVDALHLKAKVPIEKLVEVHGRISLYKCITKGCRFEY 169
Query: 420 DRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGD 599
D T +N ++ +S+ +G +GN L K P+ P + F +
Sbjct: 170 DD-------TIDNIEI-GDYSI---NGTTMKQGNLEITPPL--CPECKKPILPQSLLFDE 216
Query: 600 NVPK---YRVEQVRKXVTSSDAVFVMGSSLTV 686
N Y +E+ + +D +G+S +V
Sbjct: 217 NYSSHQFYNIEKAMDWIQEADIFIFIGTSFSV 248
>UniRef50_Q7SCL4 Cluster: Putative uncharacterized protein NCU00523.1;
n=2; Pezizomycotina|Rep: Putative uncharacterized protein
NCU00523.1 - Neurospora crassa
Length = 1220
Score = 40.7 bits (91), Expect = 0.034
Identities = 19/52 (36%), Positives = 32/52 (61%)
Frame = +3
Query: 534 SELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
+E+ + G +KPDIVFF +N+P ++ R +D + V+G+SLTV+
Sbjct: 1015 AEVPHCEKCNGLVKPDIVFFHENLPSLFFDR-RHMAEEADLILVLGTSLTVH 1065
>UniRef50_Q4PG00 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 596
Score = 40.7 bits (91), Expect = 0.034
Identities = 41/163 (25%), Positives = 69/163 (42%), Gaps = 22/163 (13%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCL--KCPYEIDRHELQ 437
H I+ +E++G++ +QN+D L G E+V++ HG+ C C + E+
Sbjct: 265 HRFIKLIEERGQLLRNYSQNIDTLEQLVGIERVLQCHGSFASASCTDPTCGFRCKGSEIA 324
Query: 438 EILTENN----PDME----SSFSMIRPDGDVDCRGN----------K*KNSELHSAQSVK 563
E + + + P E + + +P GN N +L+ S+
Sbjct: 325 EAIFKQSVPSCPRCEQRKLTQAAAAKPSKKKRKVGNGKSWRPTDESDDDNEDLNDETSLP 384
Query: 564 --GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
G LKPDI FFG+ + + D + VMG+SL V
Sbjct: 385 GFGILKPDITFFGEKLSSSFDHALLADREQVDLLIVMGTSLKV 427
>UniRef50_Q25337 Cluster: NAD-dependent deacetylase SIR2 homolog;
n=6; Leishmania|Rep: NAD-dependent deacetylase SIR2
homolog - Leishmania major
Length = 381
Score = 40.7 bits (91), Expect = 0.034
Identities = 21/62 (33%), Positives = 36/62 (58%), Gaps = 4/62 (6%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKC--PYEIDRHE 431
H IR L+ +G++ TQN+D L AG E ++E HG+ C++C P+ I+++
Sbjct: 106 HHFIRLLQDEGRLLRCCTQNIDGLEKAAGVSPELLVEAHGSFAAAACIECHTPFSIEQNY 165
Query: 432 LQ 437
L+
Sbjct: 166 LE 167
Score = 34.7 bits (76), Expect = 2.2
Identities = 13/42 (30%), Positives = 27/42 (64%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
G +KP++VFFG+N+P + + ++ V ++G+S+ V+
Sbjct: 181 GIVKPNVVFFGENLPDAFFDALHHDAPIAELVIIIGTSMQVH 222
>UniRef50_UPI0000D573CE Cluster: PREDICTED: similar to CG11305-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG11305-PA - Tribolium castaneum
Length = 627
Score = 40.3 bits (90), Expect = 0.044
Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Frame = +3
Query: 234 EIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLKC 407
++ + TH+ + EL + + +V+QN D LH ++G + + ELHG Y+ C C
Sbjct: 159 DLSMAEPTYTHMALSELYRNKILKYVVSQNCDGLHLRSGLPRTALSELHGNMYIEVCKTC 218
Query: 408 PYEIDRHELQEILTEN 455
+ L ++ TEN
Sbjct: 219 KPHKEYWRLFDV-TEN 233
>UniRef50_A1ZHW6 Cluster: NAD-dependent deacetylase; n=2;
Microscilla marina ATCC 23134|Rep: NAD-dependent
deacetylase - Microscilla marina ATCC 23134
Length = 279
Score = 40.3 bits (90), Expect = 0.044
Identities = 23/54 (42%), Positives = 32/54 (59%), Gaps = 4/54 (7%)
Frame = +3
Query: 255 NXTHLCIRELEK--KGKVTSIVTQNVDRLHHKAGS--EKVIELHGTSYLVQCLK 404
N H + E+EK GK ++VTQNVD LH +AGS + + +HG V+C K
Sbjct: 87 NPGHYAVAEMEKILGGKRFTLVTQNVDGLHFRAGSTFKNTLLIHGDLTHVRCSK 140
>UniRef50_Q7R0G2 Cluster: GLP_29_33086_34261; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_29_33086_34261 - Giardia lamblia
ATCC 50803
Length = 391
Score = 39.9 bits (89), Expect = 0.059
Identities = 18/51 (35%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGS--EKVIELHGTSYLVQCL 401
N H+ I ++ +K V ++TQN+D LH K+G+ +++E+HG L +C+
Sbjct: 126 NQGHIAIAKIMRKADVF-VITQNIDTLHTKSGALENRLVEIHGRLGLYKCV 175
>UniRef50_Q7QZ36 Cluster: GLP_464_21655_23334; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_464_21655_23334 - Giardia lamblia
ATCC 50803
Length = 559
Score = 39.9 bits (89), Expect = 0.059
Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKA--GSEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
HL +R LEK+G++ I TQN+D L +A + +I HG+ + C+ C + L+
Sbjct: 236 HLFMRLLEKRGQLQRIYTQNIDCLEVQAQITQKYIINCHGSFHTFTCIDCGAKFPMELLR 295
Query: 438 EILTE 452
+ E
Sbjct: 296 RTVVE 300
Score = 33.1 bits (72), Expect = 6.7
Identities = 16/47 (34%), Positives = 25/47 (53%)
Frame = +3
Query: 546 SAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
S ++G LKP I+FFG+ + E + + +D +GSSL V
Sbjct: 407 SGLQIRGILKPQIIFFGEKLSSDLEEFIDDDCSVADMFIAIGSSLRV 453
>UniRef50_A0C6J0 Cluster: Chromosome undetermined scaffold_152,
whole genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_152,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 449
Score = 39.9 bits (89), Expect = 0.059
Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEI 419
H ++ L+ +G++ TQN+D L AG +KVI+ HG +C++C E+
Sbjct: 283 HKFLKFLDSRGQLLKCFTQNIDGLELDAGVSQDKVIQAHGHMRTARCIECQEEV 336
>UniRef50_Q8FRV5 Cluster: NAD-dependent deacetylase 2; n=9;
Corynebacterineae|Rep: NAD-dependent deacetylase 2 -
Corynebacterium efficiens
Length = 254
Score = 39.9 bits (89), Expect = 0.059
Identities = 15/33 (45%), Positives = 22/33 (66%)
Frame = +3
Query: 309 IVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKC 407
+ TQN+D LH +AGS +V LHG+ + +C C
Sbjct: 102 VTTQNIDNLHERAGSTEVTHLHGSLFEFRCSIC 134
>UniRef50_Q03ZB1 Cluster: NAD-dependent protein deacetylase, SIR2
family; n=3; Leuconostocaceae|Rep: NAD-dependent protein
deacetylase, SIR2 family - Leuconostoc mesenteroides
subsp. mesenteroides (strain ATCC 8293 /NCDO 523)
Length = 234
Score = 39.1 bits (87), Expect = 0.10
Identities = 22/46 (47%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGS--EKVIELHGTSY 386
N H + L ++GK I+TQNVD LH KA S EK+I HG+ Y
Sbjct: 80 NVIHKKMAALTRQGKA-KIITQNVDDLHVKAASDPEKLIRFHGSLY 124
>UniRef50_A5WD15 Cluster: Silent information regulator protein Sir2;
n=2; Psychrobacter|Rep: Silent information regulator
protein Sir2 - Psychrobacter sp. PRwf-1
Length = 249
Score = 39.1 bits (87), Expect = 0.10
Identities = 23/66 (34%), Positives = 35/66 (53%), Gaps = 4/66 (6%)
Frame = +3
Query: 222 YRLAEIQLCATNXTHLCIRELEK----KGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYL 389
+R +Q N H + L++ K S++TQNVD LH +AGS+ I LHG +
Sbjct: 70 WRRGLVQDKQPNPAHYALANLQQWATDNHKDCSLITQNVDDLHEQAGSQ-AIHLHGHLWK 128
Query: 390 VQCLKC 407
+C +C
Sbjct: 129 NKCSQC 134
>UniRef50_Q9VAQ1 Cluster: CG11305-PA; n=8; Coelomata|Rep: CG11305-PA
- Drosophila melanogaster (Fruit fly)
Length = 771
Score = 39.1 bits (87), Expect = 0.10
Identities = 17/51 (33%), Positives = 29/51 (56%), Gaps = 2/51 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKC 407
TH+ + EL ++ + +V+QN D LH ++G + E+HG Y+ C C
Sbjct: 172 THMALYELHRRRLLHHVVSQNCDGLHLRSGLPRNSLSEIHGNMYVEVCKNC 222
>UniRef50_A6SP88 Cluster: Putative uncharacterized protein; n=2;
Sclerotiniaceae|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 332
Score = 39.1 bits (87), Expect = 0.10
Identities = 45/178 (25%), Positives = 79/178 (44%), Gaps = 22/178 (12%)
Frame = +3
Query: 222 YRLAEIQLCATNXTHLCIRELEKKGKVTS-----IVTQNVDRLHHKAGSEK--VIELHGT 380
YR + N H + EL K+ K +TQNVD L +AG + + LHG+
Sbjct: 89 YRRHKAFAAEPNKGHFALGELAKRMKKDGEEGFMCLTQNVDGLAQRAGHPEGSLKLLHGS 148
Query: 381 SYLVQCLK--CPYEIDRHELQE-------ILTENN----PDMESSFSMIRPDGDVDCRGN 521
++C C Y +R+ ++ I +E++ P + +MI
Sbjct: 149 LCDIKCADPVCSYR-ERNNFEDPFHPSIAITSEDDIKILPAATETQAMITFLDPTKKTTT 207
Query: 522 K*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSS--DAVFVMGSSLTVY 689
K H Q L+PDIV+FG+ +P+ +++V + + + D + V+G++ VY
Sbjct: 208 INKEELPHCPQCTTALLRPDIVWFGEALPEDTLDEVDRWIDKAPVDLILVVGTTAKVY 265
>UniRef50_Q885X7 Cluster: NAD-dependent deacetylase 2; n=4;
Pseudomonas|Rep: NAD-dependent deacetylase 2 -
Pseudomonas syringae pv. tomato
Length = 248
Score = 39.1 bits (87), Expect = 0.10
Identities = 20/53 (37%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAGS--EKVIELHGTSYLVQCLKC 407
N H I +L++ ++TQNVD H AGS E++IE+HG + C C
Sbjct: 81 NVAHYAIAQLQRIKPECWVLTQNVDGYHRAAGSPPERLIEIHGQLSPLFCQSC 133
>UniRef50_A1ZMS1 Cluster: Silent information regulator protein Sir2;
n=1; Microscilla marina ATCC 23134|Rep: Silent
information regulator protein Sir2 - Microscilla marina
ATCC 23134
Length = 276
Score = 38.7 bits (86), Expect = 0.14
Identities = 19/56 (33%), Positives = 34/56 (60%), Gaps = 3/56 (5%)
Frame = +3
Query: 312 VTQNVDRLHHKAGS--EKVIELHGTSYLVQC-LKCPYEIDRHELQEILTENNPDME 470
+T N+D H KAG+ +KV E+HG+ + +QC + C E+ + E + NN +++
Sbjct: 108 ITSNIDGQHLKAGATKDKVREVHGSIFHLQCSVPCHQEVWEGDTNEAIDVNNENLQ 163
>UniRef50_Q21KQ1 Cluster: Silent information regulator protein Sir2;
n=2; Gammaproteobacteria|Rep: Silent information
regulator protein Sir2 - Saccharophagus degradans
(strain 2-40 / ATCC 43961 / DSM 17024)
Length = 235
Score = 38.3 bits (85), Expect = 0.18
Identities = 24/69 (34%), Positives = 33/69 (47%), Gaps = 5/69 (7%)
Frame = +3
Query: 207 LGKKLYRLAEIQLCAT---NXTHLCIRELEK--KGKVTSIVTQNVDRLHHKAGSEKVIEL 371
L +K Y QL N H + E E+ G+ +VTQNVD LH GS+ +I +
Sbjct: 54 LVQKFYNARRSQLLTAAQPNKAHTALGEFEQHFSGEFL-LVTQNVDNLHELGGSKNLIHM 112
Query: 372 HGTSYLVQC 398
HG +C
Sbjct: 113 HGELLKARC 121
>UniRef50_A0D0F1 Cluster: Chromosome undetermined scaffold_33, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_33,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 264
Score = 37.5 bits (83), Expect = 0.31
Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 2/71 (2%)
Frame = +3
Query: 309 IVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFS 482
++T NVD KAG S + E+HG+ + QC C D H+ +++ + D+E FS
Sbjct: 97 VITSNVDGQFQKAGFDSNHIYEMHGSIHKFQCTPCDKLYDAHQFKDL----SIDLE-KFS 151
Query: 483 MIRPDGDVDCR 515
P +C+
Sbjct: 152 AADPLPKCECK 162
>UniRef50_A2DKY5 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 180
Score = 37.1 bits (82), Expect = 0.41
Identities = 21/78 (26%), Positives = 34/78 (43%), Gaps = 2/78 (2%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKA--GSEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H+ IR +E+ G + T N D L A KV++ HG+ C+ C E+ +E
Sbjct: 95 HILIRLIEEMGLLRRWYTTNTDCLELDAIKDKSKVVQCHGSVKHCHCIDCGAEVSMNECL 154
Query: 438 EILTENNPDMESSFSMIR 491
+ N E F ++
Sbjct: 155 SAIRGNYGRKEKGFDFVK 172
>UniRef50_Q7S223 Cluster: Putative uncharacterized protein
NCU05973.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU05973.1 - Neurospora crassa
Length = 334
Score = 37.1 bits (82), Expect = 0.41
Identities = 41/171 (23%), Positives = 70/171 (40%), Gaps = 26/171 (15%)
Frame = +3
Query: 255 NXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYE---I 419
N H + L KK +TQNVD L +AG +++ LHG+ + +QC P + I
Sbjct: 83 NAGHHALAALAKKNPNFLCLTQNVDNLSSRAGHQQQQLHTLHGSLFTLQCSSYPSQCTYI 142
Query: 420 DRHELQEILTENNPDMESSFSMIRPDGDVDCRGN------------------K*KNSELH 545
D++ + L +S S+ P D + + S L
Sbjct: 143 DKNNTLDPLCPALAPASASASINPPSNDPPNPSHSQPSNPIIPLLDPSTPLPRIPKSHLP 202
Query: 546 SAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSS---DAVFVMGSSLTVY 689
K L+P +V+FG+++ + ++ + D V V+G+S VY
Sbjct: 203 HCPQCKNLLRPGVVWFGESLNPGMLAEIDAWIDQGGPIDIVLVIGTSSVVY 253
>UniRef50_Q9RYD4 Cluster: NAD-dependent deacetylase; n=4;
Deinococci|Rep: NAD-dependent deacetylase - Deinococcus
radiodurans
Length = 246
Score = 37.1 bits (82), Expect = 0.41
Identities = 44/161 (27%), Positives = 71/161 (44%), Gaps = 6/161 (3%)
Frame = +3
Query: 225 RLAEIQLCATNXTHLCIRELEK-KGKVTSIVTQNVDRLHHKAGS----EKVIELHGTSYL 389
R ++ N H + ELE+ KG + TQNVD LH +AGS +++ELHG L
Sbjct: 69 RYRDVLAAQPNRGHELLAELERRKGPGFFLATQNVDGLHARAGSGSAGGELVELHGN--L 126
Query: 390 VQCLKCPYEIDRHELQ-EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKG 566
+Q R EL E+ PD E + + P+G
Sbjct: 127 LQA--------RDELTGEVFPLAAPD-ELTLPPLSPNGQ--------------------- 156
Query: 567 PLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
++P IV+FG+ +P ++ ++ ++ V+G+S VY
Sbjct: 157 RMRPHIVWFGEYLPVDALDAAQRAFAGAEVALVIGTSSVVY 197
>UniRef50_UPI00015B56BB Cluster: PREDICTED: similar to
ENSANGP00000025716; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000025716 - Nasonia
vitripennis
Length = 581
Score = 36.7 bits (81), Expect = 0.55
Identities = 18/51 (35%), Positives = 28/51 (54%), Gaps = 2/51 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVI--ELHGTSYLVQCLKC 407
TH+ + L K + IV+QN D LH ++G + + E+HG Y+ C C
Sbjct: 159 THMALYALYKARMLKHIVSQNCDGLHLRSGIPRPLLSEVHGNMYVEVCRTC 209
>UniRef50_Q4DP02 Cluster: Silent information regulator 2, putative;
n=4; Trypanosoma|Rep: Silent information regulator 2,
putative - Trypanosoma cruzi
Length = 359
Score = 36.3 bits (80), Expect = 0.72
Identities = 17/63 (26%), Positives = 34/63 (53%)
Frame = +3
Query: 501 DVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSL 680
D++ + + ++ G +KPD+VFFG+++P V +T + + +MG+SL
Sbjct: 158 DIELASRESREGKVPHCDRCGGVVKPDVVFFGESLPD-AFFNVFAEITEVELLLIMGTSL 216
Query: 681 TVY 689
V+
Sbjct: 217 QVH 219
>UniRef50_Q22ZC3 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 308
Score = 36.3 bits (80), Expect = 0.72
Identities = 19/40 (47%), Positives = 26/40 (65%)
Frame = +3
Query: 570 LKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
+KP IVFFG+ +P Q R + +SD V VMG+SL V+
Sbjct: 218 VKPKIVFFGEFLPN-EFYQSRDILPNSDCVVVMGTSLGVF 256
Score = 34.7 bits (76), Expect = 2.2
Identities = 16/55 (29%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQCLKCPYEID 422
H I ++ K+ ++ +TQN+D L K G KV++ HG C+ C + ++
Sbjct: 141 HKLIHQIYKRKQLLINITQNIDGLELKTGINPSKVVQAHGHMRKAHCVNCNHIVN 195
>UniRef50_Q8SSB6 Cluster: SIR2-LIKE PROTEIN INVOLVED IN TELOMERIC
SILENCING; n=1; Encephalitozoon cuniculi|Rep: SIR2-LIKE
PROTEIN INVOLVED IN TELOMERIC SILENCING -
Encephalitozoon cuniculi
Length = 425
Score = 36.3 bits (80), Expect = 0.72
Identities = 26/96 (27%), Positives = 47/96 (48%), Gaps = 7/96 (7%)
Frame = +3
Query: 156 TYTVSRICEVSESKAKVLGKKLYRLAEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRL 335
TY++S E+ + + + K + + Q AT+ ++ ++ + I TQN+D L
Sbjct: 128 TYSLSMSKELRKGYLRYISKLKNMVDKAQPSATHEFLSLYSDISRRFR---IYTQNIDGL 184
Query: 336 HHKAG-------SEKVIELHGTSYLVQCLKCPYEID 422
KAG S +++ LHG + CL C Y+I+
Sbjct: 185 EEKAGLAATKDRSTRLVYLHGNMKSLGCLYCGYKIE 220
>UniRef50_Q75DM1 Cluster: ABL004Wp; n=1; Eremothecium gossypii|Rep:
ABL004Wp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 319
Score = 36.3 bits (80), Expect = 0.72
Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 4/53 (7%)
Frame = +3
Query: 267 LCIRELEKKGKVTSIVTQNVDRLHHKAGSEK--VIELHGTSYLVQCLK--CPY 413
LC R + + +VTQNVD LH +AG + +ELHG+ + +C + C Y
Sbjct: 92 LCRRVAADERREILLVTQNVDGLHWRAGQPEASTVELHGSVFDYRCTEFLCSY 144
>UniRef50_A5DNV7 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 403
Score = 36.3 bits (80), Expect = 0.72
Identities = 17/43 (39%), Positives = 25/43 (58%)
Frame = +3
Query: 558 VKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
+KG +KPDI FFG+++ + K V D + V G+SL V
Sbjct: 270 MKGLIKPDITFFGEDLSSRFETMIGKDVEECDLLLVAGTSLKV 312
>UniRef50_A1CTI6 Cluster: SIR2 family histone deacetylase, putative;
n=8; Eurotiomycetidae|Rep: SIR2 family histone
deacetylase, putative - Aspergillus clavatus
Length = 320
Score = 36.3 bits (80), Expect = 0.72
Identities = 18/57 (31%), Positives = 33/57 (57%), Gaps = 3/57 (5%)
Frame = +3
Query: 528 KNSELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSS---DAVFVMGSSLTVY 689
+N+ H + +G L+P +V+FG+++P + V K + S D + V+G+S VY
Sbjct: 207 RNALPHCPECKEGLLRPGVVWFGESLPSQTLRAVDKWMDSGPKVDLILVIGTSSRVY 263
>UniRef50_Q5KPC9 Cluster: Hst3 protein, putative; n=2;
Filobasidiella neoformans|Rep: Hst3 protein, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 389
Score = 35.9 bits (79), Expect = 0.96
Identities = 45/164 (27%), Positives = 72/164 (43%), Gaps = 21/164 (12%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAGSE-------------KVIELHGTSYLVQCL 401
TH IR+LE+KGK+ TQN+D + G E + +ELHG V+C+
Sbjct: 113 THHFIRKLEQKGKLLRSYTQNIDGFERRMGLESGGRGKGLKKKETRNVELHGDLGRVRCV 172
Query: 402 KCPYEIDR-HELQEILTENN-PDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLK 575
C + + E E+ E PD + + C +++ A SV G L+
Sbjct: 173 LCFSDFEACDEWVEMFREGEAPDCPACWKR--------CESRINRSAR---ATSV-GRLR 220
Query: 576 PDIVFF------GDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVY 689
P IV + GD++ + V + D + +MG+SL V+
Sbjct: 221 PSIVLYDEPHPLGDDIGQLTAYDVSR---RPDLLLIMGTSLKVH 261
>UniRef50_A7TQE2 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 602
Score = 35.9 bits (79), Expect = 0.96
Identities = 18/50 (36%), Positives = 29/50 (58%)
Frame = +3
Query: 537 ELHSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
+++ A+S G +KPDI FFG+ +P + K V D + +G+SL V
Sbjct: 472 DMYVAKSF-GVMKPDITFFGEPLPDKFHNSIEKDVKGCDLLICIGTSLKV 520
>UniRef50_A2QFF9 Cluster: Complex: Sir2p is one of four Silent
Information Regulator genes in yeast. Sir2p; n=6;
Pezizomycotina|Rep: Complex: Sir2p is one of four Silent
Information Regulator genes in yeast. Sir2p -
Aspergillus niger
Length = 378
Score = 35.9 bits (79), Expect = 0.96
Identities = 19/42 (45%), Positives = 26/42 (61%)
Frame = +3
Query: 561 KGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTV 686
KG +KPDIVFFG+++P + R +D VMG+SL V
Sbjct: 182 KGLVKPDIVFFGESLPADFFDN-RDLPEQADLCIVMGTSLQV 222
>UniRef50_A6Q2C0 Cluster: Transcriptional regulator, Sir2 family;
n=2; Bacteria|Rep: Transcriptional regulator, Sir2
family - Nitratiruptor sp. (strain SB155-2)
Length = 268
Score = 35.5 bits (78), Expect = 1.3
Identities = 17/44 (38%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
Frame = +3
Query: 279 ELEKKGKVTSIVTQNVDRLHHKAGSE--KVIELHGTSYLVQCLK 404
E+ ++ K +VT NVD KAG + K+ E+HG+ + +QC+K
Sbjct: 93 EIAQRKKEYFVVTSNVDGQFQKAGFDEMKIDEVHGSIHYLQCIK 136
>UniRef50_Q6QGI5 Cluster: Putative Sir2-like protein; n=2;
Enterobacteria phage T5|Rep: Putative Sir2-like protein
- Bacteriophage T5
Length = 272
Score = 35.5 bits (78), Expect = 1.3
Identities = 15/44 (34%), Positives = 27/44 (61%), Gaps = 1/44 (2%)
Frame = +3
Query: 570 LKPDIVFFGDNVPKY-RVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
+KP+++FFG++ P Y + + +TS D + V+G S V + Y
Sbjct: 148 VKPNVIFFGEHAPAYTEMYNIFDGITSQDMIVVVGCSNQVINFY 191
>UniRef50_A2QWZ2 Cluster: Function: human SIRT5 belongs to the
Sir2-like proteins precursor; n=1; Aspergillus
niger|Rep: Function: human SIRT5 belongs to the
Sir2-like proteins precursor - Aspergillus niger
Length = 258
Score = 35.1 bits (77), Expect = 1.7
Identities = 15/51 (29%), Positives = 30/51 (58%), Gaps = 2/51 (3%)
Frame = +3
Query: 543 HSAQSVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSS--DAVFVMGSSLTVY 689
H + G L+P +V+FG+++P + ++ V + + D + V+G+S VY
Sbjct: 151 HCPECKDGLLRPGVVWFGESLPSHTIDYVDEWLNKGKVDLILVVGTSSRVY 201
>UniRef50_Q7VIN2 Cluster: NAD-dependent deacetylase; n=1;
Helicobacter hepaticus|Rep: NAD-dependent deacetylase -
Helicobacter hepaticus
Length = 255
Score = 35.1 bits (77), Expect = 1.7
Identities = 16/37 (43%), Positives = 21/37 (56%)
Frame = +3
Query: 312 VTQNVDRLHHKAGSEKVIELHGTSYLVQCLKCPYEID 422
+TQNVD L +AG VI LHG + C +C + D
Sbjct: 101 ITQNVDDLLERAGVSNVIHLHGELCKIICPQCEHIFD 137
Score = 34.7 bits (76), Expect = 2.2
Identities = 17/39 (43%), Positives = 24/39 (61%), Gaps = 1/39 (2%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPKYRV-EQVRKXVTSSDAVFVMGSS 677
G LKP IVFF + PKY + + ++S D V V+G+S
Sbjct: 154 GKLKPFIVFFYERAPKYVIMHDIFSQLSSKDCVLVIGTS 192
>UniRef50_UPI000023DCB3 Cluster: hypothetical protein FG05505.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG05505.1 - Gibberella zeae PH-1
Length = 330
Score = 34.7 bits (76), Expect = 2.2
Identities = 14/48 (29%), Positives = 28/48 (58%)
Frame = +3
Query: 555 SVKGPLKPDIVFFGDNVPKYRVEQVRKXVTSSDAVFVMGSSLTVYSSY 698
S G LKP +V FG+++ + + + ++ + V+G+SL YS++
Sbjct: 195 STAGILKPAVVMFGESIDSHVKNAAEEAIDNAGKLVVVGTSLATYSAW 242
>UniRef50_A7HID4 Cluster: Silent information regulator protein Sir2;
n=9; Deltaproteobacteria|Rep: Silent information
regulator protein Sir2 - Anaeromyxobacter sp. Fw109-5
Length = 289
Score = 34.7 bits (76), Expect = 2.2
Identities = 18/46 (39%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Frame = +3
Query: 267 LCIRELEKKGKVTSIVTQNVDRLHHKAG--SEKVIELHGTSYLVQC 398
L +R ++ G +VT NVD KAG E+V+E+HG+ + +QC
Sbjct: 93 LLLRWSQRLGLPCFVVTSNVDGQFQKAGFAEEQVLEVHGSIHHLQC 138
>UniRef50_A6DES9 Cluster: Transcriptional regulator, Sir2 family
protein; n=2; Epsilonproteobacteria|Rep: Transcriptional
regulator, Sir2 family protein - Caminibacter
mediatlanticus TB-2
Length = 264
Score = 34.7 bits (76), Expect = 2.2
Identities = 19/40 (47%), Positives = 26/40 (65%), Gaps = 3/40 (7%)
Frame = +3
Query: 309 IVTQNVDRLHHKAG-SE-KVIELHGTSYLVQCLK-CPYEI 419
+ T NVD KAG SE K++E+HG+ + +QC K C EI
Sbjct: 102 VFTSNVDGQFQKAGFSEMKIVEIHGSIHYLQCTKPCKQEI 141
>UniRef50_Q754T1 Cluster: AFL010Cp; n=1; Eremothecium gossypii|Rep:
AFL010Cp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 252
Score = 34.7 bits (76), Expect = 2.2
Identities = 16/50 (32%), Positives = 26/50 (52%)
Frame = -3
Query: 168 ILYRFVITTGIQTNILRSVVRNT*RPLTLLVYYFTEDTVRSVKNVQ*KFY 19
+LYR TG+ T L +R +P LL Y T D + ++K + ++Y
Sbjct: 43 LLYRLEYYTGVLTKDLEDTIRRLQKPAELLNYSVTSDDIGNMKTTRLEYY 92
>UniRef50_P53687 Cluster: NAD-dependent histone deacetylase HST3;
n=6; Saccharomycetales|Rep: NAD-dependent histone
deacetylase HST3 - Saccharomyces cerevisiae (Baker's
yeast)
Length = 447
Score = 34.3 bits (75), Expect = 2.9
Identities = 46/189 (24%), Positives = 77/189 (40%), Gaps = 25/189 (13%)
Frame = +3
Query: 195 KAKVLGKKLYRL-AEIQLCATNXTHLCIRELEKKGKVTSIVTQNVDRLHHKAG------- 350
K + K + RL + +QL TH I L+ + K+ TQN+D L G
Sbjct: 109 KISIFAKFMERLYSNVQLAKPTKTHKFIAHLKDRNKLLRCYTQNIDGLEESIGLTLSNRK 168
Query: 351 -----------SEKVIELHGTSYLVQCLKC--PYEIDRHELQEILTENNPDMESSFSMIR 491
+ V++LHG + C KC + R+ + + P +
Sbjct: 169 LPLTSFSSHWKNLDVVQLHGDLKTLSCTKCFQTFPWSRYWSRCLRRGELP--------LC 220
Query: 492 PDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPKYRV--EQVRKXVT--SSDAV 659
P D + NK N + S G L+P+IV +G+N P + + + + + D +
Sbjct: 221 P--DCEALINKRLNEGKRTLGSNVGILRPNIVLYGENHPSCEIITQGLNLDIIKGNPDFL 278
Query: 660 FVMGSSLTV 686
+MG+SL V
Sbjct: 279 IIMGTSLKV 287
>UniRef50_Q4S7H2 Cluster: Chromosome 13 SCAF14715, whole genome
shotgun sequence; n=6; Clupeocephala|Rep: Chromosome 13
SCAF14715, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 327
Score = 33.5 bits (73), Expect = 5.1
Identities = 17/42 (40%), Positives = 28/42 (66%), Gaps = 1/42 (2%)
Frame = +3
Query: 570 LKPDIVFFGDNVP-KYRVEQVRKXVTSSDAVFVMGSSLTVYS 692
+KPD+VFFG+++P KY + + +D + +MG+SL V S
Sbjct: 198 VKPDVVFFGEDLPQKYFLH--AEDFPKADLLIIMGTSLQVRS 237
>UniRef50_A7TCJ5 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 309
Score = 33.5 bits (73), Expect = 5.1
Identities = 16/47 (34%), Positives = 26/47 (55%)
Frame = -1
Query: 548 RVELGIFLLVPSTINIAIRSYHGETTFHIWIILC*YFLEFMSVYFIG 408
R +G+ L VPS N +R T++ I+II+C Y F+ + +G
Sbjct: 213 RKRVGVSLRVPSLTNSHLRPEDVHTSYTIFIIICLYGFCFLPTFILG 259
>UniRef50_A2DZ29 Cluster: Transcriptional regulator, Sir2 family
protein; n=4; Trichomonas vaginalis|Rep: Transcriptional
regulator, Sir2 family protein - Trichomonas vaginalis
G3
Length = 375
Score = 33.5 bits (73), Expect = 5.1
Identities = 17/48 (35%), Positives = 25/48 (52%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVIELHGTSYLVQCLKC 407
H + LEK+GK+ + TQNVD L E + +HG+ C+ C
Sbjct: 161 HYFLENLEKRGKLLRLYTQNVDALDVGILPEHLRCVHGSWRESYCMTC 208
>UniRef50_UPI000023EE57 Cluster: hypothetical protein FG09358.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG09358.1 - Gibberella zeae PH-1
Length = 301
Score = 33.1 bits (72), Expect = 6.7
Identities = 13/24 (54%), Positives = 22/24 (91%)
Frame = +3
Query: 294 GKVTSIVTQNVDRLHHKAGSEKVI 365
G+VTS++ +NVDRL+H AG++++I
Sbjct: 149 GQVTSLINENVDRLYH-AGAKRII 171
>UniRef50_Q2KH01 Cluster: Putative uncharacterized protein; n=2;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea 70-15
Length = 449
Score = 33.1 bits (72), Expect = 6.7
Identities = 16/45 (35%), Positives = 23/45 (51%), Gaps = 2/45 (4%)
Frame = +3
Query: 282 LEKKGKVTSIVTQNVDRLHHK--AGSEKVIELHGTSYLVQCLKCP 410
LE++ + +TQN+D L A K + LHG V+C CP
Sbjct: 162 LEEQPSIVLHITQNIDCLERSLPAAERKTVRLHGCLDTVRCSVCP 206
>UniRef50_A7BW37 Cluster: Putative uncharacterized protein; n=1;
Beggiatoa sp. PS|Rep: Putative uncharacterized protein -
Beggiatoa sp. PS
Length = 157
Score = 32.7 bits (71), Expect = 8.9
Identities = 12/22 (54%), Positives = 17/22 (77%)
Frame = -3
Query: 501 RHPVLSWRNYFPYLDYSLLIFL 436
+HPV S+ NYFP+ D+ L+I L
Sbjct: 52 QHPVESYLNYFPFRDFDLIILL 73
>UniRef50_Q7R0R8 Cluster: GLP_79_6121_4343; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_79_6121_4343 - Giardia lamblia ATCC
50803
Length = 592
Score = 32.7 bits (71), Expect = 8.9
Identities = 29/97 (29%), Positives = 46/97 (47%), Gaps = 10/97 (10%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDRLHHKAGSEKVI---ELHGT-SYLVQCLKCPYE-IDR 425
TH +R L +G + I+TQN+D L G +V+ ++HG+ S CL C +
Sbjct: 166 THYFLRFLADEGILKLILTQNIDELERGVGLSEVVDVKQVHGSLSNPGACLACGRSCLPE 225
Query: 426 HELQEILTENNPDMESSFSMIRP-----DGDVDCRGN 521
LQ I + E+ S I+P D D+D + +
Sbjct: 226 VVLQAIRDGSVAACENCGSAIKPGIVCYDEDIDLQSD 262
>UniRef50_A2F1E9 Cluster: Putative uncharacterized protein; n=1;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 308
Score = 32.7 bits (71), Expect = 8.9
Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 5/54 (9%)
Frame = -2
Query: 205 TFALLSDTSQILDTV*VCDYYGHTDQHPPICSQEYLTTTNF-----ISVLLHRG 59
TFA + +Q+++ + C +Y D HPP CS + N+ I +LL RG
Sbjct: 166 TFAARKEDNQLIEEL--CRHYNDVDLHPPGCSTALWLSANYGNSEGIRILLDRG 217
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 713,749,695
Number of Sequences: 1657284
Number of extensions: 15287235
Number of successful extensions: 36574
Number of sequences better than 10.0: 247
Number of HSP's better than 10.0 without gapping: 35018
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 36482
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 55371905986
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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