Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= tesS0739
(698 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI00015B4FA0 Cluster: PREDICTED: similar to chromatin ... 135 9e-31
UniRef50_Q8IRR5 Cluster: CG3187-PC, isoform C; n=4; Diptera|Rep:... 130 4e-29
UniRef50_UPI0000519F58 Cluster: PREDICTED: similar to Sirt4 CG31... 123 5e-27
UniRef50_Q1YSP9 Cluster: NAD-dependent deacetylase; n=1; gamma p... 113 5e-24
UniRef50_Q1D9X2 Cluster: Sir2 family protein; n=1; Myxococcus xa... 110 3e-23
UniRef50_A0Z2E4 Cluster: NAD-dependent deacetylase; n=1; marine ... 108 1e-22
UniRef50_A7SK95 Cluster: Predicted protein; n=1; Nematostella ve... 101 2e-20
UniRef50_Q8R216 Cluster: NAD-dependent deacetylase sirtuin-4; n=... 98 2e-19
UniRef50_A3WK56 Cluster: SIR2-like regulatory protein, NAD-depen... 97 4e-19
UniRef50_A6FYM4 Cluster: Sir2 family protein; n=1; Plesiocystis ... 97 5e-19
UniRef50_Q89EA6 Cluster: NAD-dependent deacetylase 2; n=9; Prote... 95 2e-18
UniRef50_Q7PS76 Cluster: ENSANGP00000025231; n=1; Anopheles gamb... 94 3e-18
UniRef50_Q9RL35 Cluster: NAD-dependent deacetylase 1; n=8; Actin... 94 3e-18
UniRef50_A3JEV2 Cluster: NAD-dependent deacetylase; n=2; Marinob... 93 4e-18
UniRef50_Q9FY91 Cluster: SIR2-family protein; n=12; Magnoliophyt... 93 8e-18
UniRef50_Q9Y6E7 Cluster: NAD-dependent deacetylase sirtuin-4; n=... 91 2e-17
UniRef50_Q7WLE5 Cluster: NAD-dependent deacetylase; n=47; Bacter... 91 2e-17
UniRef50_A4A8B4 Cluster: Silent information regulator protein Si... 91 3e-17
UniRef50_Q8FUC8 Cluster: NAD-dependent deacetylase 1; n=6; Coryn... 84 3e-15
UniRef50_A0PU12 Cluster: Sir2-like regulatory protein; n=1; Myco... 83 5e-15
UniRef50_Q1RPU9 Cluster: Zinc finger protein; n=1; Ciona intesti... 83 6e-15
UniRef50_A6WG46 Cluster: Silent information regulator protein Si... 83 8e-15
UniRef50_Q882K4 Cluster: NAD-dependent deacetylase 3; n=5; Pseud... 82 1e-14
UniRef50_Q7JMD3 Cluster: Putative uncharacterized protein sir-2.... 81 2e-14
UniRef50_A0JXS0 Cluster: Silent information regulator protein Si... 81 3e-14
UniRef50_Q2YZT2 Cluster: Putative uncharacterized protein; n=1; ... 66 1e-12
UniRef50_A1HLU5 Cluster: Silent information regulator protein Si... 75 2e-12
UniRef50_Q8R984 Cluster: NAD-dependent deacetylase 2; n=1; Therm... 69 2e-12
UniRef50_Q8U1Q1 Cluster: NAD-dependent deacetylase; n=19; cellul... 74 3e-12
UniRef50_UPI000049979A Cluster: Sir2 family transcriptional regu... 71 2e-11
UniRef50_A6DC77 Cluster: Silent information regulator protein Si... 66 3e-11
UniRef50_Q81NT6 Cluster: NAD-dependent deacetylase; n=11; Bacill... 62 4e-11
UniRef50_Q6AF12 Cluster: Regulatory protein, Sir2 family; n=2; A... 70 5e-11
UniRef50_A4M603 Cluster: Silent information regulator protein Si... 70 5e-11
UniRef50_A7DQD6 Cluster: Silent information regulator protein Si... 63 8e-11
UniRef50_Q73KE1 Cluster: NAD-dependent deacetylase; n=1; Trepone... 62 1e-10
UniRef50_Q5KZE8 Cluster: NAD-dependent deacetylase 2; n=3; Bacte... 66 1e-10
UniRef50_Q8ZU41 Cluster: NAD-dependent deacetylase 1; n=3; Pyrob... 60 1e-10
UniRef50_UPI000050FCF4 Cluster: COG0846: NAD-dependent protein d... 69 1e-10
UniRef50_Q12Y78 Cluster: Silent information regulator protein Si... 64 3e-10
UniRef50_Q8ZT00 Cluster: NAD-dependent deacetylase 2; n=2; cellu... 61 4e-10
UniRef50_Q55PY8 Cluster: Putative uncharacterized protein; n=2; ... 66 6e-10
UniRef50_Q9WYW0 Cluster: NAD-dependent deacetylase; n=4; Thermot... 66 6e-10
UniRef50_A7HL19 Cluster: Silent information regulator protein Si... 60 7e-10
UniRef50_Q4QB33 Cluster: Sir2-family protein-like protein; n=4; ... 66 8e-10
UniRef50_Q974M6 Cluster: NAD-dependent deacetylase; n=8; Thermop... 63 9e-10
UniRef50_Q2LSF2 Cluster: Sir2 family of NAD+-dependent deacetyla... 66 1e-09
UniRef50_A6PTK3 Cluster: Silent information regulator protein Si... 58 3e-09
UniRef50_Q5L014 Cluster: NAD-dependent deacetylase 1; n=7; Bacil... 64 3e-09
UniRef50_UPI0000D55B5A Cluster: PREDICTED: similar to CG5216-PA;... 64 4e-09
UniRef50_Q5YR82 Cluster: Putative Sir2 family regulator; n=1; No... 64 4e-09
UniRef50_A5UYK2 Cluster: Silent information regulator protein Si... 59 6e-09
UniRef50_A2QUR5 Cluster: Remark: the H. sapiens SIRT4 belongs to... 63 7e-09
UniRef50_O07595 Cluster: NAD-dependent deacetylase; n=3; Bacillu... 63 7e-09
UniRef50_A4J646 Cluster: Silent information regulator protein Si... 56 8e-09
UniRef50_A6P1S7 Cluster: Putative uncharacterized protein; n=2; ... 62 1e-08
UniRef50_UPI000049971A Cluster: Sir2 family transcriptional regu... 62 2e-08
UniRef50_A1I9S7 Cluster: NAD-dependent deacetylase; n=1; Candida... 62 2e-08
UniRef50_O94640 Cluster: NAD-dependent histone deacetylase sir2;... 62 2e-08
UniRef50_A0LG97 Cluster: Silent information regulator protein Si... 61 2e-08
UniRef50_A1FG80 Cluster: Silent information regulator protein Si... 60 5e-08
UniRef50_Q2U9Y7 Cluster: Sirtuin 4 and related class II sirtuins... 60 5e-08
UniRef50_Q21921 Cluster: NAD-dependent deacetylase SIR2 homolog;... 56 5e-08
UniRef50_O96505 Cluster: SIR2; n=4; Sophophora|Rep: SIR2 - Droso... 60 7e-08
UniRef50_A2Q9C4 Cluster: Contig An01c0250, complete genome; n=18... 60 7e-08
UniRef50_Q3F1F4 Cluster: SIR2 family protein; n=1; Bacillus thur... 59 9e-08
UniRef50_Q8CNF4 Cluster: NAD-dependent deacetylase; n=17; Staphy... 59 9e-08
UniRef50_Q8F3Z6 Cluster: NAD-dependent deacetylase; n=4; Leptosp... 59 9e-08
UniRef50_Q97MB4 Cluster: NAD-dependent deacetylase; n=7; Bacteri... 59 9e-08
UniRef50_Q4WET3 Cluster: SIR2 family histone deacetylase, putati... 59 1e-07
UniRef50_A6LP94 Cluster: Silent information regulator protein Si... 58 2e-07
UniRef50_Q88BY5 Cluster: NAD-dependent deacetylase; n=9; Bacteri... 57 4e-07
UniRef50_Q899G3 Cluster: NAD-dependent deacetylase; n=19; cellul... 57 4e-07
UniRef50_Q3A6W7 Cluster: NAD-dependent protein deacetylases, SIR... 57 5e-07
UniRef50_Q5BVX8 Cluster: SJCHGC08739 protein; n=1; Schistosoma j... 57 5e-07
UniRef50_Q9NTG7 Cluster: NAD-dependent deacetylase sirtuin-3, mi... 47 6e-07
UniRef50_UPI00015B57C0 Cluster: PREDICTED: similar to GA18743-PA... 56 6e-07
UniRef50_A3ZMQ7 Cluster: Sir2 family, possible ADP ribosyltransf... 56 6e-07
UniRef50_Q5V4Q5 Cluster: NAD-dependent deacetylase; n=2; Halobac... 56 6e-07
UniRef50_A6TNA0 Cluster: Silent information regulator protein Si... 56 1e-06
UniRef50_Q7RP35 Cluster: Sir2-like protein; n=5; Plasmodium (Vin... 56 1e-06
UniRef50_Q8REC3 Cluster: NAD-dependent deacetylase; n=3; Fusobac... 56 1e-06
UniRef50_Q67KQ0 Cluster: NAD-dependent deacetylase; n=1; Symbiob... 55 1e-06
UniRef50_Q8IKW2 Cluster: Putative uncharacterized protein; n=1; ... 55 2e-06
UniRef50_Q4UH74 Cluster: Sir2-like histone deacetylase, putative... 55 2e-06
UniRef50_UPI0000E49846 Cluster: PREDICTED: similar to Sirtuin (s... 54 3e-06
UniRef50_Q5P3W1 Cluster: NAD-dependent deacetylase 2; n=4; Prote... 54 3e-06
UniRef50_A7B9E8 Cluster: Putative uncharacterized protein; n=1; ... 54 3e-06
UniRef50_A1HU63 Cluster: Silent information regulator protein Si... 54 3e-06
UniRef50_UPI00006CB0CC Cluster: transcriptional regulator, Sir2 ... 54 4e-06
UniRef50_Q0LFI4 Cluster: Silent information regulator protein Si... 54 4e-06
UniRef50_Q0AY57 Cluster: Regulatory protein, sir2 family; n=1; S... 54 4e-06
UniRef50_A1A3R7 Cluster: Sir2-type regulatory protein; n=2; Bifi... 54 4e-06
UniRef50_A7RMK8 Cluster: Predicted protein; n=5; Eumetazoa|Rep: ... 54 4e-06
UniRef50_A7EC18 Cluster: Putative uncharacterized protein; n=1; ... 54 4e-06
UniRef50_UPI0000D578DC Cluster: PREDICTED: similar to sirtuin 5 ... 53 6e-06
UniRef50_Q07FY7 Cluster: Sirtuin (Silent mating type information... 53 6e-06
UniRef50_A5AF92 Cluster: Putative uncharacterized protein; n=1; ... 53 6e-06
UniRef50_A4QX96 Cluster: Putative uncharacterized protein; n=2; ... 45 7e-06
UniRef50_Q8G465 Cluster: Sir2-type regulatory protein; n=2; Bifi... 53 8e-06
UniRef50_Q1RPU3 Cluster: Zinc finger protein; n=1; Ciona intesti... 53 8e-06
UniRef50_A5K7T7 Cluster: NAD-dependent deacetylase, putative; n=... 53 8e-06
UniRef50_A6RXY5 Cluster: Putative uncharacterized protein; n=2; ... 53 8e-06
UniRef50_O25849 Cluster: NAD-dependent deacetylase; n=11; Bacter... 53 8e-06
UniRef50_Q9JN05 Cluster: NAD-dependent deacetylase; n=13; Campyl... 53 8e-06
UniRef50_Q8R104 Cluster: NAD-dependent deacetylase sirtuin-3; n=... 44 9e-06
UniRef50_A0NQ49 Cluster: Silent information regulator protein Si... 52 1e-05
UniRef50_A5K3P4 Cluster: Putative uncharacterized protein; n=1; ... 52 1e-05
UniRef50_Q88ZA0 Cluster: NAD-dependent deacetylase; n=4; Lactoba... 52 1e-05
UniRef50_Q9FE17 Cluster: Sir2-like protein; n=9; Magnoliophyta|R... 51 2e-05
UniRef50_Q7SB01 Cluster: Putative uncharacterized protein NCU076... 51 2e-05
UniRef50_Q9NXA8 Cluster: NAD-dependent deacetylase sirtuin-5; n=... 51 2e-05
UniRef50_Q8ZFR1 Cluster: NAD-dependent deacetylase; n=149; cellu... 48 3e-05
UniRef50_Q95Q89 Cluster: Yeast sir related protein 2.4; n=2; Cae... 51 3e-05
UniRef50_Q4P1X1 Cluster: Putative uncharacterized protein; n=1; ... 51 3e-05
UniRef50_Q298C7 Cluster: GA18650-PA; n=1; Drosophila pseudoobscu... 50 4e-05
UniRef50_Q839C6 Cluster: NAD-dependent deacetylase; n=14; Bacill... 50 4e-05
UniRef50_A1DG07 Cluster: SIR2 family histone deacetylase, putati... 43 5e-05
UniRef50_Q1QTH0 Cluster: Silent information regulator protein Si... 50 5e-05
UniRef50_Q6FKU1 Cluster: Similar to sp|P53686 Saccharomyces cere... 50 5e-05
UniRef50_Q8N6T7-2 Cluster: Isoform 2 of Q8N6T7 ; n=5; Catarrhini... 50 7e-05
UniRef50_Q54GV7 Cluster: NAD(+)-dependent deacetylase, silent in... 50 7e-05
UniRef50_Q5KDE0 Cluster: NAD-dependent histone deacetylase, puta... 50 7e-05
UniRef50_Q8N6T7 Cluster: Mono-ADP-ribosyltransferase sirtuin-6; ... 50 7e-05
UniRef50_Q8CJM9 Cluster: NAD-dependent deacetylase 2; n=3; Actin... 50 7e-05
UniRef50_Q89LY4 Cluster: NAD-dependent deacetylase 1; n=12; Prot... 50 7e-05
UniRef50_UPI000051AA14 Cluster: PREDICTED: similar to NAD-depend... 49 1e-04
UniRef50_Q6C219 Cluster: Yarrowia lipolytica chromosome F of str... 49 1e-04
UniRef50_Q9I4L0 Cluster: NAD-dependent deacetylase 1; n=10; Bact... 49 1e-04
UniRef50_Q9VH08 Cluster: CG6284-PA; n=9; Eumetazoa|Rep: CG6284-P... 49 1e-04
UniRef50_Q8Y015 Cluster: NAD-dependent deacetylase; n=11; Bacter... 49 1e-04
UniRef50_Q4APN6 Cluster: Silent information regulator protein Si... 48 2e-04
UniRef50_A7SX90 Cluster: Predicted protein; n=3; Eumetazoa|Rep: ... 48 2e-04
UniRef50_Q0CR31 Cluster: NAD-dependent histone deacetylase SIR2;... 48 2e-04
UniRef50_A7EMW8 Cluster: Putative uncharacterized protein; n=1; ... 48 2e-04
UniRef50_Q8A3H9 Cluster: NAD-dependent deacetylase; n=3; Bactero... 48 2e-04
UniRef50_A7H7B6 Cluster: Silent information regulator protein Si... 48 3e-04
UniRef50_Q6BPH5 Cluster: Debaryomyces hansenii chromosome E of s... 48 3e-04
UniRef50_Q96EB6 Cluster: NAD-dependent deacetylase sirtuin-1; n=... 48 3e-04
UniRef50_Q9CBW6 Cluster: NAD-dependent deacetylase; n=14; Mycoba... 48 3e-04
UniRef50_Q011Q8 Cluster: NAD-dependent deacetylase SIRT2; n=2; O... 38 3e-04
UniRef50_Q7S6G9 Cluster: Putative uncharacterized protein NCU047... 47 4e-04
UniRef50_UPI00004997CB Cluster: Sir2 family transcriptional regu... 47 5e-04
UniRef50_A3LN35 Cluster: NAD-dependent histone deacetylase SIR2;... 47 5e-04
UniRef50_Q046W9 Cluster: NAD-dependent protein deacetylase, SIR2... 46 7e-04
UniRef50_A1ZZG3 Cluster: NAD-dependent deacetylase; n=35; Bacter... 46 7e-04
UniRef50_Q0LIC7 Cluster: Silent information regulator protein Si... 40 7e-04
UniRef50_Q1RL71 Cluster: Zinc finger protein; n=2; Ciona intesti... 46 9e-04
UniRef50_A6XDL2 Cluster: Sirtuin 1; n=2; Schistosoma|Rep: Sirtui... 46 9e-04
UniRef50_Q6CAJ8 Cluster: Similar to sp|P53687 Saccharomyces cere... 46 9e-04
UniRef50_Q4P3S4 Cluster: Putative uncharacterized protein; n=1; ... 46 9e-04
UniRef50_A4QUX8 Cluster: Putative uncharacterized protein; n=1; ... 46 9e-04
UniRef50_Q3E2I1 Cluster: Silent information regulator protein Si... 46 0.001
UniRef50_Q1D737 Cluster: NAD-dependent deacetylase; n=1; Myxococ... 46 0.001
UniRef50_Q6C8V5 Cluster: Similar to tr|Q9FY91 Arabidopsis thalia... 46 0.001
UniRef50_A6RRE3 Cluster: Putative uncharacterized protein; n=1; ... 46 0.001
UniRef50_A4VDQ9 Cluster: Chromatin regulatory protein sir2; n=1;... 45 0.002
UniRef50_A5DJ74 Cluster: Putative uncharacterized protein; n=1; ... 45 0.002
UniRef50_Q607X6 Cluster: NAD-dependent deacetylase; n=1; Methylo... 45 0.002
UniRef50_Q0LN22 Cluster: Silent information regulator protein Si... 45 0.002
UniRef50_Q22KA8 Cluster: Transcriptional regulator, Sir2 family ... 45 0.002
UniRef50_Q175I4 Cluster: Chromatin regulatory protein sir2; n=3;... 45 0.002
UniRef50_A2F9H1 Cluster: Transcriptional regulator, Sir2 family ... 45 0.002
UniRef50_Q6MJJ2 Cluster: NAD-dependent deacetylase; n=5; Proteob... 45 0.002
UniRef50_Q7SCL4 Cluster: Putative uncharacterized protein NCU005... 44 0.003
UniRef50_Q5KA61 Cluster: Histone deacetylase, putative; n=1; Fil... 44 0.003
UniRef50_A5DSX8 Cluster: NAD-dependent histone deacetylase SIR2;... 44 0.003
UniRef50_Q9I4E1 Cluster: NAD-dependent deacetylase 2; n=6; Pseud... 44 0.003
UniRef50_A5USR3 Cluster: Silent information regulator protein Si... 44 0.004
UniRef50_P06700 Cluster: NAD-dependent histone deacetylase SIR2;... 44 0.004
UniRef50_Q5AQ47 Cluster: Potential Sir2 family histone deacetyla... 43 0.006
UniRef50_Q9NRC8 Cluster: NAD-dependent deacetylase sirtuin-7; n=... 43 0.006
UniRef50_Q3V7G9 Cluster: Putative cobalamin biosynthetic protein... 43 0.008
UniRef50_Q875P9 Cluster: HST1; n=1; Lachancea kluyveri|Rep: HST1... 43 0.008
UniRef50_Q4WFZ3 Cluster: SIR2 family histone deacetylase, putati... 43 0.008
UniRef50_Q7QZ36 Cluster: GLP_464_21655_23334; n=1; Giardia lambl... 42 0.011
UniRef50_A2DZ01 Cluster: Transcriptional regulator, Sir2 family ... 42 0.011
UniRef50_Q2H5A0 Cluster: Putative uncharacterized protein; n=1; ... 42 0.011
UniRef50_A6G0H3 Cluster: Silent information regulator protein Si... 42 0.015
UniRef50_A7AWG1 Cluster: Transcriptional regulator, Sir2 family ... 42 0.015
UniRef50_Q03ZB1 Cluster: NAD-dependent protein deacetylase, SIR2... 42 0.019
UniRef50_A1ZPG8 Cluster: NAD-dependent deacetylase; n=1; Microsc... 42 0.019
UniRef50_Q54P49 Cluster: Zn finger-containing protein; n=1; Dict... 42 0.019
UniRef50_A2DKF0 Cluster: Transcriptional regulator, Sir2 family ... 42 0.019
UniRef50_Q885X7 Cluster: NAD-dependent deacetylase 2; n=4; Pseud... 42 0.019
UniRef50_Q25337 Cluster: NAD-dependent deacetylase SIR2 homolog;... 41 0.025
UniRef50_O59923 Cluster: NAD-dependent histone deacetylase SIR2;... 41 0.025
UniRef50_UPI0000D573CE Cluster: PREDICTED: similar to CG11305-PA... 41 0.034
UniRef50_A0C6J0 Cluster: Chromosome undetermined scaffold_152, w... 41 0.034
UniRef50_Q9USN7 Cluster: Sir2 family histone deacetylase Hst2; n... 41 0.034
UniRef50_A1ZHW6 Cluster: NAD-dependent deacetylase; n=2; Microsc... 40 0.044
UniRef50_A4RCT8 Cluster: Putative uncharacterized protein; n=3; ... 40 0.044
UniRef50_Q9VAQ1 Cluster: CG11305-PA; n=8; Coelomata|Rep: CG11305... 40 0.078
UniRef50_Q7R0G2 Cluster: GLP_29_33086_34261; n=1; Giardia lambli... 40 0.078
UniRef50_Q8FRV5 Cluster: NAD-dependent deacetylase 2; n=9; Coryn... 40 0.078
UniRef50_UPI0000E49AD8 Cluster: PREDICTED: similar to NAD-depend... 39 0.10
UniRef50_A5WD15 Cluster: Silent information regulator protein Si... 39 0.10
UniRef50_A1ZMS1 Cluster: Silent information regulator protein Si... 39 0.10
UniRef50_Q6BVM7 Cluster: Similar to CA4170|IPF7784 Candida albic... 39 0.14
UniRef50_UPI00015B56BB Cluster: PREDICTED: similar to ENSANGP000... 38 0.18
UniRef50_Q55DB0 Cluster: NAD(+)-dependent deacetylase, silent in... 38 0.18
UniRef50_O94066 Cluster: Transcription regulatory protein; n=6; ... 38 0.18
UniRef50_Q23E36 Cluster: Transcriptional regulator, Sir2 family ... 38 0.24
UniRef50_A2DKY5 Cluster: Transcriptional regulator, Sir2 family ... 38 0.24
UniRef50_A0D0F1 Cluster: Chromosome undetermined scaffold_33, wh... 38 0.24
UniRef50_Q21KQ1 Cluster: Silent information regulator protein Si... 38 0.31
UniRef50_UPI0000499DEA Cluster: Sir2 family transcriptional regu... 37 0.41
UniRef50_Q75DM1 Cluster: ABL004Wp; n=1; Eremothecium gossypii|Re... 37 0.41
UniRef50_Q7S223 Cluster: Putative uncharacterized protein NCU059... 37 0.55
UniRef50_A2GAR7 Cluster: Transcriptional regulator, Sir2 family ... 36 0.72
UniRef50_Q8SSB6 Cluster: SIR2-LIKE PROTEIN INVOLVED IN TELOMERIC... 36 0.72
UniRef50_A1CD03 Cluster: SIR2 family histone deacetylase, putati... 36 0.72
UniRef50_A6Q2C0 Cluster: Transcriptional regulator, Sir2 family;... 36 0.96
UniRef50_Q6CQA7 Cluster: Kluyveromyces lactis strain NRRL Y-1140... 36 0.96
UniRef50_Q4PG00 Cluster: Putative uncharacterized protein; n=1; ... 36 0.96
UniRef50_Q9RYD4 Cluster: NAD-dependent deacetylase; n=4; Deinoco... 36 0.96
UniRef50_Q5KPC9 Cluster: Hst3 protein, putative; n=2; Filobasidi... 36 1.3
UniRef50_Q7VIN2 Cluster: NAD-dependent deacetylase; n=1; Helicob... 36 1.3
UniRef50_A7HID4 Cluster: Silent information regulator protein Si... 35 1.7
UniRef50_A6DES9 Cluster: Transcriptional regulator, Sir2 family ... 35 1.7
UniRef50_Q22ZC3 Cluster: Transcriptional regulator, Sir2 family ... 35 1.7
UniRef50_A2F8N6 Cluster: Transcriptional regulator, Sir2 family ... 35 1.7
UniRef50_A0C2R2 Cluster: Chromosome undetermined scaffold_145, w... 35 2.2
UniRef50_Q754T1 Cluster: AFL010Cp; n=1; Eremothecium gossypii|Re... 35 2.2
UniRef50_A7TCJ5 Cluster: Predicted protein; n=2; Nematostella ve... 34 2.9
UniRef50_Q2KH01 Cluster: Putative uncharacterized protein; n=2; ... 34 3.9
UniRef50_A2DZ29 Cluster: Transcriptional regulator, Sir2 family ... 33 5.1
UniRef50_Q7R0R8 Cluster: GLP_79_6121_4343; n=1; Giardia lamblia ... 33 6.7
UniRef50_A7BW37 Cluster: Putative uncharacterized protein; n=1; ... 33 8.9
UniRef50_A2F1E9 Cluster: Putative uncharacterized protein; n=1; ... 33 8.9
UniRef50_P53687 Cluster: NAD-dependent histone deacetylase HST3;... 33 8.9
>UniRef50_UPI00015B4FA0 Cluster: PREDICTED: similar to chromatin
regulatory protein sir2; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to chromatin regulatory protein sir2
- Nasonia vitripennis
Length = 736
Score = 135 bits (327), Expect = 9e-31
Identities = 64/145 (44%), Positives = 90/145 (62%)
Frame = +3
Query: 177 CEVSESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSE 356
C+ +++ + + L NVTH ++ +E GKV+ ++TQNVD LH KAGS+
Sbjct: 516 CKSDKTRRRYWARNYAAWPRFSLFQPNVTHKWLKNMEDIGKVSCVITQNVDNLHIKAGSK 575
Query: 357 KVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNS 536
V+ELHGT Y V CL C +IDR QE+L + NPDM++S IRPDGDVD ++ +
Sbjct: 576 NVVELHGTGYRVVCLSCNNKIDRFVFQEVLNKLNPDMKASCEAIRPDGDVDLSQDQIDDF 635
Query: 537 ELHSAQSVKGPLKPDIVFFGDNVPQ 611
++ G +KPDIVFFGDNVP+
Sbjct: 636 KIPPCSKCGGIMKPDIVFFGDNVPK 660
Score = 86.6 bits (205), Expect = 5e-16
Identities = 39/75 (52%), Positives = 47/75 (62%)
Frame = +1
Query: 31 LNVFYTTHGVLCEVVH**S*WSLGIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYW 210
L F T G +C + GIPDYRSE VGL+A S+ +P+ YQ+F K K R+RYW
Sbjct: 467 LKHFVNTSGKICVITGAGISTESGIPDYRSEGVGLFATSDRRPVSYQDFCKSDKTRRRYW 526
Query: 211 ARNYIGWPRFSCVQP 255
ARNY WPRFS QP
Sbjct: 527 ARNYAAWPRFSLFQP 541
>UniRef50_Q8IRR5 Cluster: CG3187-PC, isoform C; n=4; Diptera|Rep:
CG3187-PC, isoform C - Drosophila melanogaster (Fruit
fly)
Length = 312
Score = 130 bits (313), Expect = 4e-29
Identities = 60/122 (49%), Positives = 79/122 (64%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N TH + E++ +V ++VTQNVD LH KAGS V+E+HG+ Y+V+CL C Y IDRHE
Sbjct: 113 NATHHALARFEREERVQAVVTQNVDRLHTKAGSRNVVEVHGSGYVVKCLSCEYRIDRHEF 172
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQY 614
Q IL NP + + MIRPDGDV+ +N + G LKP+IVFFGD+VP+
Sbjct: 173 QSILASLNPAFKDAPDMIRPDGDVEIPLEYIENFRIPECTQCGGDLKPEIVFFGDSVPRP 232
Query: 615 RV 620
RV
Sbjct: 233 RV 234
Score = 97.9 bits (233), Expect = 2e-19
Identities = 41/67 (61%), Positives = 49/67 (73%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTSHISVFE 279
GIPDYRSE VGLYARSNHKP+Q+ EFVK VR+RYWARN++GWP+FS QP +
Sbjct: 61 GIPDYRSEGVGLYARSNHKPVQHMEFVKSSAVRKRYWARNFVGWPKFSATQPNATHHALA 120
Query: 280 N*RRREK 300
R E+
Sbjct: 121 RFEREER 127
>UniRef50_UPI0000519F58 Cluster: PREDICTED: similar to Sirt4
CG3187-PC, isoform C isoform 2; n=2; Endopterygota|Rep:
PREDICTED: similar to Sirt4 CG3187-PC, isoform C isoform
2 - Apis mellifera
Length = 302
Score = 123 bits (296), Expect = 5e-27
Identities = 59/119 (49%), Positives = 78/119 (65%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N TH + +LE K+ I+TQNVD LH KAGS+KVIELHGT++ V CL C I R+ L
Sbjct: 108 NNTHKILTKLENANKIRYIITQNVDNLHTKAGSKKVIELHGTAFRVMCLNCNERICRYYL 167
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQ 611
Q+I NP+M + MIRPDGDV+ + + ++ + G LKPDI+FFGDNVP+
Sbjct: 168 QDIFDRINPNMTVTSQMIRPDGDVELTQEQVEEFKVPICEKCDGILKPDIIFFGDNVPR 226
Score = 93.9 bits (223), Expect = 3e-18
Identities = 37/54 (68%), Positives = 45/54 (83%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
GIPDYRSE VGLYARSNHKP+ Y++F +R+RYWARNYIGWPRFS ++P +
Sbjct: 56 GIPDYRSEGVGLYARSNHKPVLYKDFCNSDAIRRRYWARNYIGWPRFSSIKPNN 109
>UniRef50_Q1YSP9 Cluster: NAD-dependent deacetylase; n=1; gamma
proteobacterium HTCC2207|Rep: NAD-dependent deacetylase
- gamma proteobacterium HTCC2207
Length = 270
Score = 113 bits (271), Expect = 5e-24
Identities = 56/128 (43%), Positives = 73/128 (57%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + LEK G V+ +VTQNVD LH +AGS+KVI+LHG V CL C + R L
Sbjct: 76 NGAHSALASLEKAGAVSCLVTQNVDGLHQRAGSQKVIDLHGRVDSVSCLSCKLRLPRAPL 135
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQY 614
Q L NNPD I PDGD D + ++ ++ G LKPD VFFGD+VP
Sbjct: 136 QTWLEANNPDFAKLAGAIAPDGDADVDNLDHSSMQVPDCENCGGVLKPDAVFFGDSVPAQ 195
Query: 615 RVGTSQKR 638
RV ++++
Sbjct: 196 RVADAEQQ 203
Score = 45.6 bits (103), Expect = 0.001
Identities = 21/52 (40%), Positives = 31/52 (59%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
G+P YR++ G + R P+ +QEF + RQR+WARN +GW S +P
Sbjct: 27 GVPTYRNQR-GEWQRK--PPVTHQEFTGNHQARQRFWARNLVGWRFMSSARP 75
>UniRef50_Q1D9X2 Cluster: Sir2 family protein; n=1; Myxococcus
xanthus DK 1622|Rep: Sir2 family protein - Myxococcus
xanthus (strain DK 1622)
Length = 287
Score = 110 bits (265), Expect = 3e-23
Identities = 56/140 (40%), Positives = 73/140 (52%)
Frame = +3
Query: 189 ESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIE 368
E +A+ + L N H + ELE+ G V ++TQNVD LHH AGS +VIE
Sbjct: 69 EVRARYWARSLMGWPRFSSARPNAAHAALAELEQAGHVRGLITQNVDGLHHAAGSSRVIE 128
Query: 369 LHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHS 548
LHG V+CL C + R LQ L NP +RPDGD D + + ++ +
Sbjct: 129 LHGALAQVRCLACGAQEAREALQARLLSLNPGFSLEVLELRPDGDADLTSEQLSSFQVPA 188
Query: 549 AQSVKGPLKPDIVFFGDNVP 608
G LKPD+VFFGDNVP
Sbjct: 189 CLVCGGTLKPDVVFFGDNVP 208
Score = 64.1 bits (149), Expect = 3e-09
Identities = 31/61 (50%), Positives = 43/61 (70%), Gaps = 1/61 (1%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP-TSHISVF 276
GIPDYR G AR+ + PIQ++EF+ P+VR RYWAR+ +GWPRFS +P +H ++
Sbjct: 42 GIPDYRGP--GTRARARN-PIQHREFLTRPEVRARYWARSLMGWPRFSSARPNAAHAALA 98
Query: 277 E 279
E
Sbjct: 99 E 99
>UniRef50_A0Z2E4 Cluster: NAD-dependent deacetylase; n=1; marine
gamma proteobacterium HTCC2080|Rep: NAD-dependent
deacetylase - marine gamma proteobacterium HTCC2080
Length = 288
Score = 108 bits (259), Expect = 1e-22
Identities = 53/149 (35%), Positives = 80/149 (53%)
Frame = +3
Query: 189 ESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIE 368
ES+ + G+ + ++ N H + + E+ G+ T ++TQNVD LH AGS+ VI+
Sbjct: 58 ESRQRYWGRSMIGWPNVRDARCNANHSALVDFEQSGRSTLVITQNVDRLHQAAGSQNVID 117
Query: 369 LHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHS 548
LHG V CL C +R +Q+ L E NP +M RPDGD D + ++ +
Sbjct: 118 LHGRLDRVVCLDCGAGYERDRVQQELEELNPQHRGFEAMARPDGDADLSAEQVRDVNIWD 177
Query: 549 AQSVKGPLKPDIVFFGDNVPQYRVGTSQK 635
+ G LKPD+VFFG +P+ RV Q+
Sbjct: 178 CEVCGGMLKPDVVFFGGTIPRERVTRCQE 206
Score = 51.6 bits (118), Expect = 2e-05
Identities = 24/45 (53%), Positives = 31/45 (68%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWP 234
GIP YR G + R+ +PIQ+QEFV+ + RQRYW R+ IGWP
Sbjct: 31 GIPTYRDTS-GTWLRN--RPIQHQEFVQQRESRQRYWGRSMIGWP 72
>UniRef50_A7SK95 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 323
Score = 101 bits (242), Expect = 2e-20
Identities = 55/128 (42%), Positives = 73/128 (57%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + +LE G V S+VTQNVD LH KAGS+ VIELHG S+ V CL C R L
Sbjct: 128 NEAHYALAKLETLGSVHSLVTQNVDALHTKAGSKNVIELHGCSHRVICLGCNQITARTAL 187
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQY 614
Q+ + E NPD + PDGD K+ ++ ++ G LKP++VFFGD+VP+
Sbjct: 188 QKRMIEFNPDWHAVGQGQAPDGDTFLTSEAVKDFKVPPCKACGGILKPEVVFFGDSVPKQ 247
Query: 615 RVGTSQKR 638
V + R
Sbjct: 248 IVNIAYDR 255
Score = 77.4 bits (182), Expect = 3e-13
Identities = 32/52 (61%), Positives = 39/52 (75%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GI DYRSE GLYA +N +P++YQ F+K +RQRYWARNY+GWP F QP
Sbjct: 76 GIRDYRSEGKGLYAITNDRPMEYQVFLKSAVMRQRYWARNYVGWPEFGSRQP 127
>UniRef50_Q8R216 Cluster: NAD-dependent deacetylase sirtuin-4; n=7;
cellular organisms|Rep: NAD-dependent deacetylase
sirtuin-4 - Mus musculus (Mouse)
Length = 333
Score = 97.9 bits (233), Expect = 2e-19
Identities = 50/128 (39%), Positives = 69/128 (53%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + E+ GK+ +VTQNVD LH KAGS+++ ELHG + V CL C + R L
Sbjct: 119 NPAHWALSNWERLGKLHWLVTQNVDALHSKAGSQRLTELHGCMHRVLCLNCGEQTARRVL 178
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQY 614
QE NP + + PDGDV + ++ ++ GPLKPD+VFFGD V
Sbjct: 179 QERFQALNPSWSAEAQGVAPDGDVFLTEEQVRSFQVPCCDRCGGPLKPDVVFFGDTVNPD 238
Query: 615 RVGTSQKR 638
+V +R
Sbjct: 239 KVDFVHRR 246
Score = 84.6 bits (200), Expect = 2e-15
Identities = 38/68 (55%), Positives = 47/68 (69%)
Frame = +1
Query: 103 IPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTSHISVFEN 282
IPDYRSE VGLYAR++ +PIQ+ +FV+ VRQRYWARN++GWP+FS QP N
Sbjct: 68 IPDYRSEKVGLYARTDRRPIQHIDFVRSAPVRQRYWARNFVGWPQFSSHQPNPAHWALSN 127
Query: 283 *RRREK*H 306
R K H
Sbjct: 128 WERLGKLH 135
>UniRef50_A3WK56 Cluster: SIR2-like regulatory protein,
NAD-dependent protein deacetylase; n=1; Idiomarina
baltica OS145|Rep: SIR2-like regulatory protein,
NAD-dependent protein deacetylase - Idiomarina baltica
OS145
Length = 279
Score = 97.1 bits (231), Expect = 4e-19
Identities = 49/122 (40%), Positives = 68/122 (55%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H I + ++ G + +++TQNVD LH KAGS VI LHG + + C+ C R +L
Sbjct: 83 NRAHQVIAQFQQHGFIDTVITQNVDGLHQKAGSSTVINLHGYANDIVCMTCGDRSPRFDL 142
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQY 614
+ E NP S S+I+PDGD + +H G LKPD+V+FGDNVP+
Sbjct: 143 HQRYAELNPRFNQSVSVIKPDGDAKLSAPTDEFKLIH-CDHCGGILKPDVVYFGDNVPKK 201
Query: 615 RV 620
RV
Sbjct: 202 RV 203
Score = 39.1 bits (87), Expect = 0.10
Identities = 20/52 (38%), Positives = 28/52 (53%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIP YR+ G + S P+Q+ +F+ R+RYWAR+ GW QP
Sbjct: 34 GIPAYRNAQ-GQWVHS--PPMQHHDFMNNDAARKRYWARSLGGWLNLYHAQP 82
>UniRef50_A6FYM4 Cluster: Sir2 family protein; n=1; Plesiocystis
pacifica SIR-1|Rep: Sir2 family protein - Plesiocystis
pacifica SIR-1
Length = 297
Score = 96.7 bits (230), Expect = 5e-19
Identities = 52/151 (34%), Positives = 79/151 (52%)
Frame = +3
Query: 168 SRICEVSESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKA 347
S E E++A+ + + ++ N H + +LE G ++ ++TQNVD LHH+A
Sbjct: 69 SAYVEDPEARARYWSRAVVGWPKLSRARPNAAHRVLAQLEAAGVLSGLITQNVDRLHHQA 128
Query: 348 GSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK* 527
GS V+ELHG V+CL C R LQ+ L NP + + PDGD + +
Sbjct: 129 GSRAVVELHGALAEVRCLSCQTIEGRDALQDRLLGLNPSWRHLDAAMAPDGDAELE-DPV 187
Query: 528 KNSELHSAQSVKGPLKPDIVFFGDNVPQYRV 620
++ Q+ G LKP++VFFG+ VPQ V
Sbjct: 188 DRFQVADCQACGGLLKPNVVFFGEQVPQATV 218
Score = 54.8 bits (126), Expect = 2e-06
Identities = 24/54 (44%), Positives = 36/54 (66%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
GIPDYR E G AR+ + PI++ +V+ P+ R RYW+R +GWP+ S +P +
Sbjct: 49 GIPDYRGE--GTRARARN-PIRFSAYVEDPEARARYWSRAVVGWPKLSRARPNA 99
>UniRef50_Q89EA6 Cluster: NAD-dependent deacetylase 2; n=9;
Proteobacteria|Rep: NAD-dependent deacetylase 2 -
Bradyrhizobium japonicum
Length = 273
Score = 94.7 bits (225), Expect = 2e-18
Identities = 48/126 (38%), Positives = 71/126 (56%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + LE G+ ++TQNVD LH AG +VI+LHG LV+C+ C + R E
Sbjct: 83 NDAHHALARLEANGRCGMLLTQNVDRLHQSAGHRQVIDLHGRLDLVRCMGCGAKTPRSEF 142
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQY 614
Q+ L N + + + PDGD D + ++ + ++ G LKPD+VFFG+NVP+
Sbjct: 143 QDTLGRANAEWLALDASDAPDGDADLEHADFSSFKVPACEACGGILKPDVVFFGENVPRD 202
Query: 615 RVGTSQ 632
V T+Q
Sbjct: 203 VVATAQ 208
Score = 50.0 bits (114), Expect = 5e-05
Identities = 23/52 (44%), Positives = 32/52 (61%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYR G + R+ +P+ +Q F+ R+RYWAR+ IGW RF +P
Sbjct: 34 GIPDYRDSH-GNWKRT--QPVNFQAFMSEEHTRRRYWARSLIGWRRFGQARP 82
>UniRef50_Q7PS76 Cluster: ENSANGP00000025231; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000025231 - Anopheles gambiae
str. PEST
Length = 182
Score = 93.9 bits (223), Expect = 3e-18
Identities = 38/52 (73%), Positives = 44/52 (84%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYRSE VGLYARSNHKPIQ+ +FVK R+RYWARNY+GWP+FS + P
Sbjct: 14 GIPDYRSEGVGLYARSNHKPIQHGDFVKSEATRKRYWARNYVGWPKFSSIAP 65
Score = 78.2 bits (184), Expect = 2e-13
Identities = 49/124 (39%), Positives = 67/124 (54%)
Frame = +3
Query: 249 ATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRH 428
A NVTH + LE++G+++ IVTQNVD LH KAGS++VIELHG+ +
Sbjct: 64 APNVTHYTLARLEREGRISGIVTQNVDRLHGKAGSKQVIELHGSGF-------------- 109
Query: 429 ELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
+N+ M RPDGDV+ + ++ G LKP+IVFFGDNVP
Sbjct: 110 ------DDNSTSM-------RPDGDVELSMEYVQGFKIPPCPQCGGNLKPEIVFFGDNVP 156
Query: 609 QYRV 620
R+
Sbjct: 157 MPRI 160
>UniRef50_Q9RL35 Cluster: NAD-dependent deacetylase 1; n=8;
Actinomycetales|Rep: NAD-dependent deacetylase 1 -
Streptomyces coelicolor
Length = 299
Score = 93.9 bits (223), Expect = 3e-18
Identities = 50/122 (40%), Positives = 63/122 (51%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + + G +T ++TQNVD LH AGSE V+ELHG+ V CL C R EL
Sbjct: 96 NAGHRSVAAFGRHGLLTGVITQNVDGLHQAAGSEGVVELHGSLDRVVCLSCGVLSPRREL 155
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQY 614
L E N + I PDGD D + + + G LKPD+VFFG+NVP
Sbjct: 156 ARRLEEANAGFSPVAAGINPDGDADLTDEQVGDFRVVPCAVCGGVLKPDVVFFGENVPPR 215
Query: 615 RV 620
RV
Sbjct: 216 RV 217
Score = 61.7 bits (143), Expect = 2e-08
Identities = 28/59 (47%), Positives = 38/59 (64%), Gaps = 1/59 (1%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS-HISV 273
GIPDYR E L S H P+ YQ+F +P+ R+RYWAR+++GW F +P + H SV
Sbjct: 47 GIPDYRGEGGSL---SRHTPMTYQDFTAHPEARRRYWARSHLGWRTFGRARPNAGHRSV 102
>UniRef50_A3JEV2 Cluster: NAD-dependent deacetylase; n=2;
Marinobacter|Rep: NAD-dependent deacetylase -
Marinobacter sp. ELB17
Length = 300
Score = 93.5 bits (222), Expect = 4e-18
Identities = 51/147 (34%), Positives = 78/147 (53%)
Frame = +3
Query: 189 ESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIE 368
+++ + G+ L ++ + N +H I +LE + +VTQNVD LH KAG++ V +
Sbjct: 86 QTRQRYWGRSLIGWPLMRNASPNASHHHISQLEMLNHSSLVVTQNVDRLHQKAGTQAVTD 145
Query: 369 LHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHS 548
LHG + V C+ C Y R E+ + NP + + + PDGD D N + +L
Sbjct: 146 LHGRADEVLCMSCDYRCMRDEVHQRCAILNPQFSAFTADVAPDGDADLDINF-ADFQLAD 204
Query: 549 AQSVKGPLKPDIVFFGDNVPQYRVGTS 629
G LKPD+VFFGD VP+ RV +
Sbjct: 205 CPVCGGILKPDVVFFGDYVPKQRVNAA 231
Score = 53.2 bits (122), Expect = 6e-06
Identities = 28/63 (44%), Positives = 36/63 (57%), Gaps = 3/63 (4%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS---HIS 270
GIPDYR D G + R +P+Q+Q F+ + RQRYW R+ IGWP P + HIS
Sbjct: 59 GIPDYRDGD-GAWKRK--QPVQHQAFMGSVQTRQRYWGRSLIGWPLMRNASPNASHHHIS 115
Query: 271 VFE 279
E
Sbjct: 116 QLE 118
>UniRef50_Q9FY91 Cluster: SIR2-family protein; n=12;
Magnoliophyta|Rep: SIR2-family protein - Arabidopsis
thaliana (Mouse-ear cress)
Length = 451
Score = 92.7 bits (220), Expect = 8e-18
Identities = 52/136 (38%), Positives = 73/136 (53%), Gaps = 18/136 (13%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQ-- 437
H + LEK G++ ++TQNVD LHH+AGS+ +ELHGT Y V CL+C + R Q
Sbjct: 237 HTALASLEKAGRINFMITQNVDRLHHRAGSDP-LELHGTVYTVMCLECGFSFPRDLFQDQ 295
Query: 438 --------------EILTENNPDMESSFSMI-RPDGDVDCRGNK*KNS-ELHSAQSVKGP 569
E + +P E SF M RPDGD++ + + + KG
Sbjct: 296 LKAINPKASWAEAIESIDHGDPGSEKSFGMKQRPDGDIEIDEKFWEEGFHIPVCEKCKGV 355
Query: 570 LKPDIVFFGDNVPQYR 617
LKPD++FFGDN+P+ R
Sbjct: 356 LKPDVIFFGDNIPKER 371
Score = 64.9 bits (151), Expect = 2e-09
Identities = 29/52 (55%), Positives = 37/52 (71%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYRS + G Y+ S KPI +QEF + + R+RYWAR+Y GW RF+ QP
Sbjct: 184 GIPDYRSPN-GAYS-SGFKPITHQEFTRSSRARRRYWARSYAGWRRFTAAQP 233
>UniRef50_Q9Y6E7 Cluster: NAD-dependent deacetylase sirtuin-4; n=23;
Deuterostomia|Rep: NAD-dependent deacetylase sirtuin-4 -
Homo sapiens (Human)
Length = 314
Score = 91.1 bits (216), Expect = 2e-17
Identities = 51/128 (39%), Positives = 67/128 (52%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + EK GK+ +VTQNVD LH KAGS ++ ELHG V CL C + R L
Sbjct: 122 NPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVL 181
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQY 614
QE NP + + PDGDV + ++ ++ + G LKPD+VFFGD V
Sbjct: 182 QERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPD 241
Query: 615 RVGTSQKR 638
+V KR
Sbjct: 242 KVDFVHKR 249
Score = 85.8 bits (203), Expect = 9e-16
Identities = 34/52 (65%), Positives = 44/52 (84%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYRSE VGLYAR++ +PIQ+ +FV+ +RQRYWARN++GWP+FS QP
Sbjct: 70 GIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQP 121
>UniRef50_Q7WLE5 Cluster: NAD-dependent deacetylase; n=47;
Bacteria|Rep: NAD-dependent deacetylase - Bordetella
bronchiseptica (Alcaligenes bronchisepticus)
Length = 274
Score = 91.1 bits (216), Expect = 2e-17
Identities = 46/122 (37%), Positives = 65/122 (53%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + L ++G+V +VTQNVD LH AG +V++LHG V+C++C + R
Sbjct: 83 NAAHHALARLAQRGQVDLLVTQNVDRLHQAAGGREVLDLHGRLDEVRCMQCDWRGPRGPW 142
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQY 614
Q L NP + + PDGD D G + S G +KPD+VFFG+ VP+
Sbjct: 143 QHTLELANPQWAALQAGAAPDGDADLEGQDFSRFVVPSCPRCGGIVKPDVVFFGETVPRE 202
Query: 615 RV 620
RV
Sbjct: 203 RV 204
Score = 45.6 bits (103), Expect = 0.001
Identities = 22/54 (40%), Positives = 30/54 (55%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
GIPDYR + G + R PI +Q F+ R RYWAR+ +GW F +P +
Sbjct: 34 GIPDYR-DGQGQWKRK--PPIDFQAFMGGQPARARYWARSMVGWRHFGQARPNA 84
>UniRef50_A4A8B4 Cluster: Silent information regulator protein Sir2;
n=1; Congregibacter litoralis KT71|Rep: Silent
information regulator protein Sir2 - Congregibacter
litoralis KT71
Length = 297
Score = 90.6 bits (215), Expect = 3e-17
Identities = 49/119 (41%), Positives = 64/119 (53%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEI 443
H + +LE G V+ IVTQNVD LH +AGS +V +LHG V+CL C R LQ+
Sbjct: 88 HRLLAQLEHHGLVSHIVTQNVDRLHQRAGSIRVTDLHGRLDRVRCLGCETLSSRDVLQKA 147
Query: 444 LTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQYRV 620
L NP + + RPDGD D + + S G L PD+VFFG ++P RV
Sbjct: 148 LERLNPHINHTTIEARPDGDADMPDAMVEGITVPSCDLCDGTLMPDVVFFGGSIPGSRV 206
Score = 54.0 bits (124), Expect = 3e-06
Identities = 27/54 (50%), Positives = 33/54 (61%)
Frame = +1
Query: 94 SLGIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
S GIP YR E G + RSN PI +QEFV + RQRYW R+ +GWP +P
Sbjct: 34 STGIPTYRDEK-GAWLRSN--PITHQEFVADRRQRQRYWGRSLLGWPAVRDAKP 84
>UniRef50_Q8FUC8 Cluster: NAD-dependent deacetylase 1; n=6;
Corynebacterium|Rep: NAD-dependent deacetylase 1 -
Corynebacterium efficiens
Length = 281
Score = 84.2 bits (199), Expect = 3e-15
Identities = 49/126 (38%), Positives = 67/126 (53%), Gaps = 5/126 (3%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N TH + ELE+ G ++ IVTQNVD LH +AGSE ++ LHG + CL+C + R L
Sbjct: 81 NRTHYALVELERAGLLSGIVTQNVDGLHRRAGSENLVALHGDLATIVCLQCGHREARELL 140
Query: 435 QEILTENNPDMESSF----SMIRPDGDVDCRGNK*KNSELHS-AQSVKGPLKPDIVFFGD 599
L NP S S + PDGDV + + + A+ LKPD+V+FG+
Sbjct: 141 DARLDHLNPGYFDSIALDPSAVNPDGDVTLDDHHVQRFTMAGCARCGSVLLKPDVVYFGE 200
Query: 600 NVPQYR 617
VP R
Sbjct: 201 PVPSIR 206
Score = 49.2 bits (112), Expect = 1e-04
Identities = 25/61 (40%), Positives = 35/61 (57%), Gaps = 1/61 (1%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPT-SHISVF 276
GIPDYRS L + +P+ YQEF P RYWAR+++GW + QP +H ++
Sbjct: 32 GIPDYRSPRGSL---NQGRPMTYQEFRFDPVASHRYWARSFVGWRVMADAQPNRTHYALV 88
Query: 277 E 279
E
Sbjct: 89 E 89
>UniRef50_A0PU12 Cluster: Sir2-like regulatory protein; n=1;
Mycobacterium ulcerans Agy99|Rep: Sir2-like regulatory
protein - Mycobacterium ulcerans (strain Agy99)
Length = 283
Score = 83.4 bits (197), Expect = 5e-15
Identities = 49/126 (38%), Positives = 68/126 (53%), Gaps = 5/126 (3%)
Frame = +3
Query: 249 ATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRH 428
A N H + LE+ G VT ++TQNVD LH KAGS+ V+ LHGT V CL C + I R
Sbjct: 73 APNAGHRALAALERAGVVTGVITQNVDLLHTKAGSKNVVNLHGTYAQVTCLGCGHTISRS 132
Query: 429 ELQEILTENNPD-MESSFSM----IRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFF 593
L L NP +E + ++ + PD D ++ + G LKPDIV+F
Sbjct: 133 TLAAELESLNPGFIERAEAVGGLAVAPDADAVIADT--ESFRYIDCRCCGGMLKPDIVYF 190
Query: 594 GDNVPQ 611
G++VP+
Sbjct: 191 GESVPK 196
Score = 46.4 bits (105), Expect = 7e-04
Identities = 23/54 (42%), Positives = 29/54 (53%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
GIPDYR D SN P+ ++F P RQRYWARN++GW P +
Sbjct: 28 GIPDYRGPDS---PPSN--PMTIRQFTSDPVFRQRYWARNHVGWRHMDDTAPNA 76
>UniRef50_Q1RPU9 Cluster: Zinc finger protein; n=1; Ciona
intestinalis|Rep: Zinc finger protein - Ciona
intestinalis (Transparent sea squirt)
Length = 320
Score = 83.0 bits (196), Expect = 6e-15
Identities = 33/59 (55%), Positives = 48/59 (81%), Gaps = 1/59 (1%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP-TSHISV 273
GIPDYRS+DVGLYAR+NHKP+Q+Q+FVK R+ YWAR+Y+GW +++ +P +H+ +
Sbjct: 78 GIPDYRSKDVGLYARTNHKPMQHQDFVKSADKRKIYWARSYLGWAKYNAWKPNAAHVKL 136
Score = 82.6 bits (195), Expect = 8e-15
Identities = 49/146 (33%), Positives = 74/146 (50%), Gaps = 1/146 (0%)
Frame = +3
Query: 186 SESKAKVLGKKLYR-LAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKV 362
S K K+ + Y A+ N H+ + +EK G+V TQNVD L KAG+E++
Sbjct: 106 SADKRKIYWARSYLGWAKYNAWKPNAAHVKLAAMEKDGRVDWHTTQNVDGLMVKAGAEQL 165
Query: 363 IELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSEL 542
ELHG V C++C +DR+ +Q+ + E N + PD DV + +
Sbjct: 166 TELHGQMRRVVCMRCNGLLDRNVMQKDMDELNKHWSAEVLGYGPDADVFICEEDVIDFNV 225
Query: 543 HSAQSVKGPLKPDIVFFGDNVPQYRV 620
+ + G LKP++ FFGDNVP +V
Sbjct: 226 PACRKCGGDLKPNVTFFGDNVPGSKV 251
>UniRef50_A6WG46 Cluster: Silent information regulator protein Sir2;
n=4; Actinomycetales|Rep: Silent information regulator
protein Sir2 - Kineococcus radiotolerans SRS30216
Length = 279
Score = 82.6 bits (195), Expect = 8e-15
Identities = 50/152 (32%), Positives = 75/152 (49%), Gaps = 4/152 (2%)
Frame = +3
Query: 186 SESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVI 365
+E++ + G+ + N H + LE G VT ++TQNVD L AG+ +V+
Sbjct: 55 AEARRRYWGRSHVGWEHFRRARPNDAHRAVAALEGAGVVTGVITQNVDGLDLAAGTREVV 114
Query: 366 ELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMES---SFSMIRPDGDVDCRGNK*KNS 536
ELHG V CL+C R EL E L+ NP ++ + PDGD D + +
Sbjct: 115 ELHGNLDRVVCLRCGELTARAELAERLSAANPGFDARVEQLHALNPDGDADLTEAQLEGF 174
Query: 537 ELHSAQSV-KGPLKPDIVFFGDNVPQYRVGTS 629
+ + + LK D+VFFG+ VP+ RV S
Sbjct: 175 RTVACRRCGEDALKADVVFFGETVPKDRVARS 206
Score = 51.6 bits (118), Expect = 2e-05
Identities = 22/52 (42%), Positives = 29/52 (55%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYR L H P+ YQEF + R+RYW R+++GW F +P
Sbjct: 29 GIPDYRGPGGSL---QRHTPMTYQEFTGSAEARRRYWGRSHVGWEHFRRARP 77
>UniRef50_Q882K4 Cluster: NAD-dependent deacetylase 3; n=5;
Pseudomonas|Rep: NAD-dependent deacetylase 3 -
Pseudomonas syringae pv. tomato
Length = 281
Score = 81.8 bits (193), Expect = 1e-14
Identities = 44/127 (34%), Positives = 65/127 (51%), Gaps = 1/127 (0%)
Frame = +3
Query: 237 IQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYE 416
I N H + L+ + + ++TQNVD LH +AGS+ VIELHG+ + V CL C
Sbjct: 78 ISASQANAAHRALAALQAENLIKGLITQNVDALHTQAGSQDVIELHGSLHRVLCLDCQQR 137
Query: 417 IDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGP-LKPDIVFF 593
DR +QE + +N + + PDGD ++ +G LKPD+VFF
Sbjct: 138 SDRTAIQEQMLAHNLYLADVHATQAPDGDTLLDPAYEAGFKVPECPHCQGKRLKPDVVFF 197
Query: 594 GDNVPQY 614
G+NV +
Sbjct: 198 GENVASH 204
Score = 61.3 bits (142), Expect = 2e-08
Identities = 29/51 (56%), Positives = 34/51 (66%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQ 252
GIPDYR +D G+ R +P+ YQEFV P RQRYWAR +GWPR S Q
Sbjct: 35 GIPDYRDKD-GV--RRGAQPMMYQEFVGNPAARQRYWARAMLGWPRISASQ 82
>UniRef50_Q7JMD3 Cluster: Putative uncharacterized protein sir-2.2;
n=4; Caenorhabditis|Rep: Putative uncharacterized
protein sir-2.2 - Caenorhabditis elegans
Length = 289
Score = 81.4 bits (192), Expect = 2e-14
Identities = 44/127 (34%), Positives = 64/127 (50%), Gaps = 3/127 (2%)
Frame = +3
Query: 249 ATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRH 428
A N+ H + + E + ++TQNVD LH KAGS+ V ELHG++ V+C C Y R
Sbjct: 95 APNINHYALSKWEASDRFQWLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYIESRQ 154
Query: 429 ELQEILTENNPDMESSF---SMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGD 599
Q+ L NP + + PDGD+ K ++ S G +K D+ FFG+
Sbjct: 155 TYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGGLMKTDVTFFGE 214
Query: 600 NVPQYRV 620
NV +V
Sbjct: 215 NVNMDKV 221
Score = 80.6 bits (190), Expect = 3e-14
Identities = 31/52 (59%), Positives = 41/52 (78%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYRS+DVGLYAR HKPI +Q++++ + RQRYW+RN++ WPRF P
Sbjct: 45 GIPDYRSKDVGLYARIAHKPIYFQDYMRSNRCRQRYWSRNFLAWPRFGQAAP 96
>UniRef50_A0JXS0 Cluster: Silent information regulator protein Sir2
precursor; n=11; Actinomycetales|Rep: Silent information
regulator protein Sir2 precursor - Arthrobacter sp.
(strain FB24)
Length = 306
Score = 80.6 bits (190), Expect = 3e-14
Identities = 49/136 (36%), Positives = 69/136 (50%), Gaps = 6/136 (4%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H LE++G +T ++TQNVD LH AGS V++LHG V CL C R L
Sbjct: 104 NDGHAAAARLEQRGLLTGLITQNVDRLHEDAGSVNVVDLHGRFDRVACLSCARRYSRTLL 163
Query: 435 QEILTENNPD-MESSFS----MIRPDGDVDCRGNK-*KNSELHSAQSVKGPLKPDIVFFG 596
+L E NP +E + + + PD D + ++ + + G LKPD V+FG
Sbjct: 164 AGVLEELNPGFLEQALADGVVEMAPDADATVEDSALIRSFVVAHCPACGGTLKPDFVYFG 223
Query: 597 DNVPQYRVGTSQKRSD 644
+NVP+ RV S D
Sbjct: 224 ENVPKDRVERSYAMVD 239
Score = 52.4 bits (120), Expect = 1e-05
Identities = 25/52 (48%), Positives = 29/52 (55%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYR D A P+ YQEF+ + RQRYWARN+IGW P
Sbjct: 57 GIPDYRGPDAAPRA-----PMTYQEFIGHAGNRQRYWARNHIGWSHLRRADP 103
>UniRef50_Q2YZT2 Cluster: Putative uncharacterized protein; n=1;
uncultured delta proteobacterium|Rep: Putative
uncharacterized protein - uncultured delta
proteobacterium
Length = 254
Score = 65.7 bits (153), Expect(2) = 1e-12
Identities = 42/127 (33%), Positives = 62/127 (48%), Gaps = 1/127 (0%)
Frame = +3
Query: 120 GGCWSVCP**SQTYTVSRICEVSESKAKVLGKKLYRLAEI-QLCATNVTHLCIRELEKKG 296
GG WS + + I AKV K L + E+ N H + +LE G
Sbjct: 39 GGLWSRF----DPFEYAHIDAFKRDPAKVW-KMLLEIDEVLNQAKPNRAHYALAKLEAAG 93
Query: 297 KVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESS 476
+ +I+TQN+D +H +AGS+ VIE HG + + C KC + R +EI E+ P +
Sbjct: 94 ILKAIITQNIDNMHQRAGSKNVIEFHGNAETLTCTKCKKKFTR---EEITMESIPPLCEC 150
Query: 477 FSMIRPD 497
+IRPD
Sbjct: 151 KGVIRPD 157
Score = 29.9 bits (64), Expect(2) = 1e-12
Identities = 9/18 (50%), Positives = 15/18 (83%)
Frame = +3
Query: 561 KGPLKPDIVFFGDNVPQY 614
KG ++PD+VFFG+ +P +
Sbjct: 151 KGVIRPDVVFFGETIPAH 168
>UniRef50_A1HLU5 Cluster: Silent information regulator protein Sir2;
n=1; Thermosinus carboxydivorans Nor1|Rep: Silent
information regulator protein Sir2 - Thermosinus
carboxydivorans Nor1
Length = 261
Score = 74.9 bits (176), Expect = 2e-12
Identities = 45/129 (34%), Positives = 67/129 (51%)
Frame = +3
Query: 222 YRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCL 401
+R+A + N HL + EL + G VT +VTQNVD LH +AGS+ V ELHGT V C+
Sbjct: 69 WRIARLWEVQPNPGHLALAELAQAGFVTKLVTQNVDGLHQRAGSQGVAELHGTLRTVSCI 128
Query: 402 KCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPD 581
KC + D + + +N E + G SE + + +G L+PD
Sbjct: 129 KCGSQYDSRQ----MLPHNDTWEEDYK----------AGRYRHGSECYCPR-CQGQLRPD 173
Query: 582 IVFFGDNVP 608
+V FG+++P
Sbjct: 174 VVLFGESLP 182
>UniRef50_Q8R984 Cluster: NAD-dependent deacetylase 2; n=1;
Thermoanaerobacter tengcongensis|Rep: NAD-dependent
deacetylase 2 - Thermoanaerobacter tengcongensis
Length = 250
Score = 68.9 bits (161), Expect(2) = 2e-12
Identities = 32/92 (34%), Positives = 53/92 (57%), Gaps = 2/92 (2%)
Frame = +3
Query: 228 LAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKC 407
L+ ++ N H + E+EK+G + ++TQN+D LH KAGS+KV E+HG + CL+C
Sbjct: 77 LSSMRNAEPNEAHYILSEMEKEGIIAGVITQNIDNLHQKAGSKKVYEVHGNTREGSCLRC 136
Query: 408 PYEIDRHELQEILTENN--PDMESSFSMIRPD 497
++ L+E + + P + M+RPD
Sbjct: 137 GEKVSFELLEEKVAKEEIPPRCDRCGGMLRPD 168
Score = 25.8 bits (54), Expect(2) = 2e-12
Identities = 9/15 (60%), Positives = 12/15 (80%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVP 608
G L+PD+V FGD +P
Sbjct: 163 GMLRPDVVLFGDPMP 177
>UniRef50_Q8U1Q1 Cluster: NAD-dependent deacetylase; n=19; cellular
organisms|Rep: NAD-dependent deacetylase - Pyrococcus
furiosus
Length = 250
Score = 74.1 bits (174), Expect = 3e-12
Identities = 37/95 (38%), Positives = 54/95 (56%), Gaps = 3/95 (3%)
Frame = +3
Query: 222 YRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCL 401
+R+ +I N H+ + ELEK G + +++TQNVD LH +AGS+ VIELHG + V+C
Sbjct: 66 WRIKKILEAKPNPAHIALAELEKMGIIKAVITQNVDDLHREAGSKNVIELHGNIFRVKCT 125
Query: 402 KCPYEIDRHELQEI---LTENNPDMESSFSMIRPD 497
C Y E I L++ P S++RPD
Sbjct: 126 SCSYREYLKESDRIGWLLSQELPRCPKCGSLLRPD 160
>UniRef50_UPI000049979A Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 319
Score = 71.3 bits (167), Expect = 2e-11
Identities = 30/51 (58%), Positives = 38/51 (74%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYE 416
H +R+LE+ GK+ I+TQNVD LH AGS KVIELHGT + QC+KC Y+
Sbjct: 95 HFALRKLEEIGKLEEIITQNVDNLHQLAGSRKVIELHGTGKICQCIKCGYQ 145
>UniRef50_A6DC77 Cluster: Silent information regulator protein Sir2;
n=1; Caminibacter mediatlanticus TB-2|Rep: Silent
information regulator protein Sir2 - Caminibacter
mediatlanticus TB-2
Length = 243
Score = 66.5 bits (155), Expect(2) = 3e-11
Identities = 32/82 (39%), Positives = 50/82 (60%), Gaps = 1/82 (1%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + +LEKKG + +++TQN+D LH KAGS+ VIE HGT+ ++CL C + +
Sbjct: 79 NEAHYFLADLEKKGILKAVITQNIDNLHQKAGSKNVIEFHGTANKLECLNCKSKFNSF-- 136
Query: 435 QEILTENNPDM-ESSFSMIRPD 497
E+ EN P + +++PD
Sbjct: 137 -EVPLENIPPLCPKCNGVLKPD 157
Score = 24.6 bits (51), Expect(2) = 3e-11
Identities = 9/16 (56%), Positives = 12/16 (75%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPQ 611
G LKPD VFF + +P+
Sbjct: 152 GVLKPDFVFFKEPIPK 167
>UniRef50_Q81NT6 Cluster: NAD-dependent deacetylase; n=11; Bacillus
cereus group|Rep: NAD-dependent deacetylase - Bacillus
anthracis
Length = 242
Score = 62.1 bits (144), Expect(2) = 4e-11
Identities = 33/95 (34%), Positives = 50/95 (52%)
Frame = +3
Query: 213 KKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLV 392
K+++++ N H + ELE++GK +I+TQN+D LH GS+ VI+LHGT
Sbjct: 67 KEIFQINTFHQYKPNRGHRFLAELEEQGKDITILTQNIDGLHQVGGSKHVIDLHGTLQTA 126
Query: 393 QCLKCPYEIDRHELQEILTENNPDMESSFSMIRPD 497
C KC D LQ ++ P E ++ PD
Sbjct: 127 HCPKCKMGYD---LQYMIDHEVPRCEKCNFILNPD 158
Score = 28.3 bits (60), Expect(2) = 4e-11
Identities = 9/16 (56%), Positives = 13/16 (81%)
Frame = +3
Query: 570 LKPDIVFFGDNVPQYR 617
L PD+V +GD +PQY+
Sbjct: 155 LNPDVVLYGDTLPQYQ 170
>UniRef50_Q6AF12 Cluster: Regulatory protein, Sir2 family; n=2;
Actinobacteria (class)|Rep: Regulatory protein, Sir2
family - Leifsonia xyli subsp. xyli
Length = 283
Score = 70.1 bits (164), Expect = 5e-11
Identities = 47/133 (35%), Positives = 69/133 (51%), Gaps = 4/133 (3%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + LE G +VTQNVD LH KAGS +V++LHG+ V CL C R +
Sbjct: 90 NDGHRALAALEDAGAAAGVVTQNVDGLHKKAGSRRVVDLHGSVDRVLCLVCGQLFAREAI 149
Query: 435 QEILTENNPDMESSFSM-IRPDGDVDCRGNK*KNSELHSAQSVKGP-LKPDIVFFGDNVP 608
+ NP +++ ++ PDGD ++ + +V G LKPD+VFFG+ +P
Sbjct: 150 TAGIDAANPWLDAEGAVEFAPDGDAIVTD---IDAFVIPDCTVCGERLKPDVVFFGEFIP 206
Query: 609 --QYRVGTSQKRS 641
YR ++ RS
Sbjct: 207 AETYREASALVRS 219
Score = 45.6 bits (103), Expect = 0.001
Identities = 22/52 (42%), Positives = 34/52 (65%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPDYR E G R+ P+ +Q+F+ + R+RYWA +++G+ RFS +P
Sbjct: 43 GIPDYRGE--GAPKRT---PMTFQQFLAEDRHRKRYWAGSHLGYRRFSAARP 89
>UniRef50_A4M603 Cluster: Silent information regulator protein Sir2;
n=1; Petrotoga mobilis SJ95|Rep: Silent information
regulator protein Sir2 - Petrotoga mobilis SJ95
Length = 256
Score = 70.1 bits (164), Expect = 5e-11
Identities = 34/80 (42%), Positives = 51/80 (63%), Gaps = 1/80 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHE-LQ 437
TH + +LEK+GK+ IVTQN+D LH KAGS+KV E+HG + C KC + + E L+
Sbjct: 85 THKFLVQLEKEGKLKGIVTQNIDSLHQKAGSKKVYEIHGGCWKNYCTKCKRKYSQEEILE 144
Query: 438 EILTENNPDMESSFSMIRPD 497
++ E P ++ +I+PD
Sbjct: 145 KMNNEVVPKCDNCGGVIKPD 164
>UniRef50_A7DQD6 Cluster: Silent information regulator protein Sir2;
n=1; Candidatus Nitrosopumilus maritimus SCM1|Rep:
Silent information regulator protein Sir2 - Candidatus
Nitrosopumilus maritimus SCM1
Length = 242
Score = 63.3 bits (147), Expect(2) = 8e-11
Identities = 36/81 (44%), Positives = 47/81 (58%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H I ELEK V S+ TQN+D LH KAGS KV+ELHG+ ++C C + E+
Sbjct: 79 NQGHKAIAELEKFADVVSL-TQNIDGLHQKAGSTKVLELHGSIVKIKCTVCDFS---DEI 134
Query: 435 QEILTENNPDMESSFSMIRPD 497
TE NP + S++RPD
Sbjct: 135 MTDFTE-NPPLCKCGSILRPD 154
Score = 26.2 bits (55), Expect(2) = 8e-11
Identities = 8/14 (57%), Positives = 14/14 (100%)
Frame = +3
Query: 570 LKPDIVFFGDNVPQ 611
L+PD+V+FG+++PQ
Sbjct: 151 LRPDVVWFGESLPQ 164
>UniRef50_Q73KE1 Cluster: NAD-dependent deacetylase; n=1; Treponema
denticola|Rep: NAD-dependent deacetylase - Treponema
denticola
Length = 251
Score = 61.7 bits (143), Expect(2) = 1e-10
Identities = 23/52 (44%), Positives = 37/52 (71%)
Frame = +3
Query: 258 VTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPY 413
+ H + +LEK+G + +++TQN+D LH KAGS+ VIE+HG+ + C+ C Y
Sbjct: 84 IVHTVLADLEKRGILKAVITQNIDLLHQKAGSKNVIEVHGSPSVHYCINCSY 135
Score = 27.5 bits (58), Expect(2) = 1e-10
Identities = 11/28 (39%), Positives = 15/28 (53%)
Frame = +3
Query: 528 KNSELHSAQSVKGPLKPDIVFFGDNVPQ 611
K E+ P+KP I FFG+ +PQ
Sbjct: 147 KTGEVPRCPKCGSPIKPAITFFGEALPQ 174
>UniRef50_Q5KZE8 Cluster: NAD-dependent deacetylase 2; n=3;
Bacteria|Rep: NAD-dependent deacetylase 2 - Geobacillus
kaustophilus
Length = 247
Score = 66.5 bits (155), Expect(2) = 1e-10
Identities = 37/95 (38%), Positives = 55/95 (57%)
Frame = +3
Query: 213 KKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLV 392
K+++ L + A N H +R LE+ GK +I+TQN+D LH KAGS VIELHGT +
Sbjct: 68 KRMFSLKMMGGFAPNDGHRFLRWLEEMGKTVTILTQNIDGLHTKAGSTNVIELHGT---L 124
Query: 393 QCLKCPYEIDRHELQEILTENNPDMESSFSMIRPD 497
Q CP ++++L I P E ++++PD
Sbjct: 125 QTATCPSCGNKYDLSFINRHEVPRCEKCQTIVKPD 159
Score = 22.6 bits (46), Expect(2) = 1e-10
Identities = 8/14 (57%), Positives = 11/14 (78%)
Frame = +3
Query: 570 LKPDIVFFGDNVPQ 611
+KPD+V FG VP+
Sbjct: 156 VKPDVVLFGGLVPR 169
>UniRef50_Q8ZU41 Cluster: NAD-dependent deacetylase 1; n=3;
Pyrobaculum|Rep: NAD-dependent deacetylase 1 -
Pyrobaculum aerophilum
Length = 254
Score = 59.7 bits (138), Expect(2) = 1e-10
Identities = 29/81 (35%), Positives = 41/81 (50%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + E+E+ GK+ +++TQNVD LH AGS+ VIELHG C C + E
Sbjct: 84 NPAHYALAEMERLGKLCAVITQNVDRLHQAAGSKNVIELHGALEYAVCTNCGSKYALAEA 143
Query: 435 QEILTENNPDMESSFSMIRPD 497
+ P +I+PD
Sbjct: 144 LKWRKSGAPRCPKCGGVIKPD 164
Score = 29.1 bits (62), Expect(2) = 1e-10
Identities = 10/16 (62%), Positives = 14/16 (87%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPQ 611
G +KPD+VFFG+ +PQ
Sbjct: 159 GVIKPDVVFFGEPLPQ 174
>UniRef50_UPI000050FCF4 Cluster: COG0846: NAD-dependent protein
deacetylases, SIR2 family; n=1; Brevibacterium linens
BL2|Rep: COG0846: NAD-dependent protein deacetylases,
SIR2 family - Brevibacterium linens BL2
Length = 309
Score = 68.5 bits (160), Expect = 1e-10
Identities = 53/167 (31%), Positives = 76/167 (45%), Gaps = 11/167 (6%)
Frame = +3
Query: 153 QTYTVSRICEVSESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDX 332
Q T+ + +A+ + ++ N HL + +L V IVTQNVD
Sbjct: 67 QPMTIQTFLSHPDQRARYWARSWVGWPRMRSARPNAAHLGLAQLP----VAGIVTQNVDG 122
Query: 333 LHHKAGSEK-----VIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSM---- 485
LH A E+ VI+LHG+ V CLK + DR +Q L+E NP+ +
Sbjct: 123 LHQAAAREEGSRSPVIDLHGSLDRVICLKEGHMFDRDWVQIQLSELNPEFAKLVGIDPID 182
Query: 486 --IRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQYRV 620
PDGDVD + + G LKPD+V+FGD+VP R+
Sbjct: 183 VETAPDGDVDLEETA--DFIVTDCPRCGGILKPDVVYFGDSVPPARL 227
Score = 51.6 bits (118), Expect = 2e-05
Identities = 21/54 (38%), Positives = 31/54 (57%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
G+PDYR D +P+ Q F+ +P R RYWAR+++GWPR +P +
Sbjct: 54 GVPDYRGPDA-----VPRQPMTIQTFLSHPDQRARYWARSWVGWPRMRSARPNA 102
>UniRef50_Q12Y78 Cluster: Silent information regulator protein Sir2;
n=1; Methanococcoides burtonii DSM 6242|Rep: Silent
information regulator protein Sir2 - Methanococcoides
burtonii (strain DSM 6242)
Length = 245
Score = 63.7 bits (148), Expect(2) = 3e-10
Identities = 30/82 (36%), Positives = 48/82 (58%), Gaps = 1/82 (1%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
++ H + +LE+KG + +I+TQN+D LH KAGS+ VIE+HG+ CL C + +
Sbjct: 76 SIVHSVLSKLEEKGIIKAIITQNIDMLHQKAGSKNVIEVHGSPQEHVCLACGKKYSYEYI 135
Query: 435 QEIL-TENNPDMESSFSMIRPD 497
E+L E P +++PD
Sbjct: 136 AELLKAEGFPLCNECGGLVKPD 157
Score = 23.8 bits (49), Expect(2) = 3e-10
Identities = 9/16 (56%), Positives = 13/16 (81%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPQ 611
G +KPDIVF+G+ + Q
Sbjct: 152 GLVKPDIVFYGEMLRQ 167
>UniRef50_Q8ZT00 Cluster: NAD-dependent deacetylase 2; n=2; cellular
organisms|Rep: NAD-dependent deacetylase 2 - Pyrobaculum
aerophilum
Length = 249
Score = 60.9 bits (141), Expect(2) = 4e-10
Identities = 31/78 (39%), Positives = 44/78 (56%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEI 443
H I ELE G V ++TQNVD LH +AGS V+ELHG+ + +C+KC + L +
Sbjct: 78 HYAIAELEAMGVVRGVITQNVDGLHQRAGSRLVVELHGSIWRARCVKCG---SVYILDKP 134
Query: 444 LTENNPDMESSFSMIRPD 497
+ E P ++RPD
Sbjct: 135 VEEVPPLCRKCGGLLRPD 152
Score = 26.2 bits (55), Expect(2) = 4e-10
Identities = 9/16 (56%), Positives = 14/16 (87%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPQ 611
G L+PD+V+FG+ +PQ
Sbjct: 147 GLLRPDVVWFGEPLPQ 162
>UniRef50_Q55PY8 Cluster: Putative uncharacterized protein; n=2;
Filobasidiella neoformans|Rep: Putative uncharacterized
protein - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 361
Score = 66.5 bits (155), Expect = 6e-10
Identities = 48/140 (34%), Positives = 69/140 (49%), Gaps = 22/140 (15%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKA-------GSEKVIELHGTSYLVQCLKCPY 413
N TH+ I L G +++TQNVD LH KA ++ELHGT V C+K +
Sbjct: 111 NPTHIYIAALLHLGLAPNLITQNVDNLHPKAYRLLSPNTKPPILELHGTLAKVHCMKHRH 170
Query: 414 EIDRHELQEILTENNP-------DMESSFSMIR--PDGDVDCRGNK*KNSELHSAQSVKG 566
E R E QE ++ NP + E + + R PDGDVD RG + S + +
Sbjct: 171 EQSRDEYQEQISRLNPIWDEAAKEAERTGTQPRTNPDGDVDLRGANYNTFNVPSCRICEA 230
Query: 567 P------LKPDIVFFGDNVP 608
+KP++VFFG+ +P
Sbjct: 231 EGEKPTMVKPNVVFFGETIP 250
Score = 45.6 bits (103), Expect = 0.001
Identities = 25/63 (39%), Positives = 39/63 (61%), Gaps = 5/63 (7%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVK-YPK---VRQRYWARNYIGWPRFSCVQPT-SH 264
GI YR ++ G Y+ N+KPI + E V+ P+ R+RYWAR+++G+P QP +H
Sbjct: 56 GIRAYRGKE-GSYSNPNYKPILFHELVEDTPRGEMFRRRYWARSFLGYPPVRDAQPNPTH 114
Query: 265 ISV 273
I +
Sbjct: 115 IYI 117
>UniRef50_Q9WYW0 Cluster: NAD-dependent deacetylase; n=4;
Thermotoga|Rep: NAD-dependent deacetylase - Thermotoga
maritima
Length = 246
Score = 66.5 bits (155), Expect = 6e-10
Identities = 29/82 (35%), Positives = 54/82 (65%), Gaps = 1/82 (1%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHE- 431
N+ H+ + +LE+KG + +++TQN+D LH +AGS+KVIELHG C++C + +
Sbjct: 77 NLAHVLLAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDV 136
Query: 432 LQEILTENNPDMESSFSMIRPD 497
++++ + + P + S+IRP+
Sbjct: 137 IKKLESSDVPLCDDCNSLIRPN 158
>UniRef50_A7HL19 Cluster: Silent information regulator protein Sir2;
n=1; Fervidobacterium nodosum Rt17-B1|Rep: Silent
information regulator protein Sir2 - Fervidobacterium
nodosum Rt17-B1
Length = 244
Score = 60.1 bits (139), Expect(2) = 7e-10
Identities = 32/83 (38%), Positives = 45/83 (54%), Gaps = 2/83 (2%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKC--PYEIDRH 428
N H + LEK V ++TQN+D LH KAGS+KV E+HG CLKC Y++
Sbjct: 78 NEIHYLLAYLEKLNIVKGVITQNIDNLHKKAGSQKVAEIHGNVRTWSCLKCGKRYDLFNS 137
Query: 429 ELQEILTENNPDMESSFSMIRPD 497
+ +E L + N E + +PD
Sbjct: 138 QHKEFLIDRNFRCECG-GVTKPD 159
Score = 26.2 bits (55), Expect(2) = 7e-10
Identities = 10/15 (66%), Positives = 12/15 (80%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVP 608
G KPDIVFFG+ +P
Sbjct: 154 GVTKPDIVFFGEMLP 168
>UniRef50_Q4QB33 Cluster: Sir2-family protein-like protein; n=4;
Trypanosomatidae|Rep: Sir2-family protein-like protein -
Leishmania major
Length = 320
Score = 66.1 bits (154), Expect = 8e-10
Identities = 51/162 (31%), Positives = 64/162 (39%), Gaps = 23/162 (14%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKA------------------GSEKVIELHGT 380
N H+ ++ K G V I+TQNVD LHH A + ELHG
Sbjct: 87 NAAHMALQAFTKSGAVAHILTQNVDGLHHLATYGGVGDAEEEHYYKYTTSDAPLKELHGN 146
Query: 381 SYLVQCLKCPYEIDRHELQEILTENNPDMESSF----SMIRPDGDVDCRGNK*KNSELHS 548
+ V C C + + R LQ L E NP + S RPDGD L
Sbjct: 147 IHNVICTSCGFFMPRARLQRELRERNPGFYEQYGADVSRTRPDGDYSAPTEAVNAMHLVM 206
Query: 549 AQSVKGPLKPDIVFFGDNVPQYRV-GTSQKRSD*Q*CCICNG 671
G KP +V FG+NVP+ V T D C +C G
Sbjct: 207 CPRCNGFFKPHVVLFGENVPKPIVEATMSLVRDKASCLLCLG 248
Score = 41.1 bits (92), Expect = 0.025
Identities = 17/44 (38%), Positives = 30/44 (68%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGW 231
GIPDYR + G Y R++ + +Q+F++ ++RYWAR+ +G+
Sbjct: 36 GIPDYRGPN-GQYHRADFVLLTFQKFMRDDNEKRRYWARSMLGY 78
>UniRef50_Q974M6 Cluster: NAD-dependent deacetylase; n=8;
Thermoprotei|Rep: NAD-dependent deacetylase - Sulfolobus
tokodaii
Length = 250
Score = 63.3 bits (147), Expect(2) = 9e-10
Identities = 38/84 (45%), Positives = 46/84 (54%), Gaps = 3/84 (3%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGT---SYLVQCLKCPYEIDR 425
N H + ELEK G + +I+TQN+D LH AGS VIELHG Y V CLK Y+ D
Sbjct: 77 NRAHYALAELEKMGLIRAIITQNIDGLHQLAGSRNVIELHGNMRKCYCVNCLK-TYDSDT 135
Query: 426 HELQEILTENNPDMESSFSMIRPD 497
L +I E P +IRPD
Sbjct: 136 -VLDKIDKEGLPPKCECGGVIRPD 158
Score = 22.6 bits (46), Expect(2) = 9e-10
Identities = 8/22 (36%), Positives = 15/22 (68%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPQYRVGTS 629
G ++PD+V FG+ P Y + ++
Sbjct: 153 GVIRPDVVLFGE--PVYNISSA 172
>UniRef50_Q2LSF2 Cluster: Sir2 family of NAD+-dependent deacetylase;
n=2; Syntrophus aciditrophicus SB|Rep: Sir2 family of
NAD+-dependent deacetylase - Syntrophus aciditrophicus
(strain SB)
Length = 271
Score = 65.7 bits (153), Expect = 1e-09
Identities = 47/130 (36%), Positives = 66/130 (50%), Gaps = 2/130 (1%)
Frame = +3
Query: 228 LAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGS--EKVIELHGTSYLVQCL 401
LAE Q N HL + ELEK GK+ ++TQN+D LH KAG+ EKV ELHG ++CL
Sbjct: 85 LAEAQ---PNRAHLAVAELEKIGKLNCVITQNIDNLHQKAGNAPEKVYELHGNMRWLKCL 141
Query: 402 KCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPD 581
C DR + E+ E ++ DG C +G +KPD
Sbjct: 142 SCG---DRVSVPEMFRET--------ALQEMDGFPFC-------------AKCQGLMKPD 177
Query: 582 IVFFGDNVPQ 611
++FFG+ +P+
Sbjct: 178 VIFFGEALPE 187
>UniRef50_A6PTK3 Cluster: Silent information regulator protein Sir2;
n=1; Victivallis vadensis ATCC BAA-548|Rep: Silent
information regulator protein Sir2 - Victivallis
vadensis ATCC BAA-548
Length = 248
Score = 58.0 bits (134), Expect(2) = 3e-09
Identities = 31/93 (33%), Positives = 45/93 (48%)
Frame = +3
Query: 219 LYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQC 398
LYRL E A H + LE+ G + + TQN+D LH +AGS V ELHG+ C
Sbjct: 72 LYRLEEFHPAAV---HRALAGLEQSGLLRGVYTQNIDLLHQQAGSRHVYELHGSPARHHC 128
Query: 399 LKCPYEIDRHELQEILTENNPDMESSFSMIRPD 497
LKC + E+ ++ +++PD
Sbjct: 129 LKCRKQFGYAEIAPLVLAGKVPRCGCGGLVKPD 161
Score = 26.2 bits (55), Expect(2) = 3e-09
Identities = 9/16 (56%), Positives = 14/16 (87%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPQ 611
G +KPDIVF+G+N+ +
Sbjct: 156 GLVKPDIVFYGENLDE 171
>UniRef50_Q5L014 Cluster: NAD-dependent deacetylase 1; n=7;
Bacillaceae|Rep: NAD-dependent deacetylase 1 -
Geobacillus kaustophilus
Length = 242
Score = 64.1 bits (149), Expect = 3e-09
Identities = 28/62 (45%), Positives = 40/62 (64%)
Frame = +3
Query: 222 YRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCL 401
YR+ +Q C + H + + E++G V +IVTQNVD H +AGS +VIELHG+ V C
Sbjct: 65 YRIRTLQQCQPHDGHRLLADWERRGIVQTIVTQNVDGFHQEAGSRRVIELHGSLRTVHCQ 124
Query: 402 KC 407
+C
Sbjct: 125 RC 126
>UniRef50_UPI0000D55B5A Cluster: PREDICTED: similar to CG5216-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG5216-PA - Tribolium castaneum
Length = 722
Score = 63.7 bits (148), Expect = 4e-09
Identities = 44/118 (37%), Positives = 59/118 (50%), Gaps = 3/118 (2%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEI 443
H I+ LE GK+ TQN+D L A EKVIE HG+ C KC +++ ++EI
Sbjct: 285 HRFIKMLENYGKLLRNYTQNIDTLEKVANIEKVIECHGSFATATCTKCGHKVTADAIREI 344
Query: 444 -LTENNPDMESSFSMIRPDGDVDCRGNK*KNS-ELHSAQSV-KGPLKPDIVFFGDNVP 608
L + P E V C +NS E+ Q V G +KPDIVFFG+ +P
Sbjct: 345 VLAQQIPLCEKCHP---GKTSVPCIEEYKENSEEIDYRQLVSSGIMKPDIVFFGEGLP 399
>UniRef50_Q5YR82 Cluster: Putative Sir2 family regulator; n=1;
Nocardia farcinica|Rep: Putative Sir2 family regulator -
Nocardia farcinica
Length = 248
Score = 63.7 bits (148), Expect = 4e-09
Identities = 28/72 (38%), Positives = 44/72 (61%), Gaps = 2/72 (2%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGS--EKVIELHGTSYLVQCLKCPYEIDRH 428
N HL + +LE+ G+ +I+TQNVD LH +AGS ++V+E+HG + V C+ C YE
Sbjct: 76 NAGHLALVDLERAGRAVTIITQNVDRLHQRAGSSPQRVVEIHGNMFEVVCVGCDYETGMA 135
Query: 429 ELQEILTENNPD 464
++ + PD
Sbjct: 136 DVLARVEAGEPD 147
>UniRef50_A5UYK2 Cluster: Silent information regulator protein Sir2;
n=2; Roseiflexus|Rep: Silent information regulator
protein Sir2 - Roseiflexus sp. RS-1
Length = 261
Score = 58.8 bits (136), Expect(2) = 6e-09
Identities = 30/90 (33%), Positives = 43/90 (47%)
Frame = +3
Query: 228 LAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKC 407
L + A N H + LE+ + +I+TQN D LH +AGS +V ELHG CL+C
Sbjct: 77 LDRVLAAAPNAAHYALAALEQHRTLRAIITQNFDGLHQRAGSREVYELHGHLRTATCLEC 136
Query: 408 PYEIDRHELQEILTENNPDMESSFSMIRPD 497
+I L + P S ++PD
Sbjct: 137 ERQIPTQALLPRIRRGEPPRCSCGHPLKPD 166
Score = 24.2 bits (50), Expect(2) = 6e-09
Identities = 8/15 (53%), Positives = 12/15 (80%)
Frame = +3
Query: 567 PLKPDIVFFGDNVPQ 611
PLKPD+V F + +P+
Sbjct: 162 PLKPDVVLFDEMLPR 176
>UniRef50_A2QUR5 Cluster: Remark: the H. sapiens SIRT4 belongs to a
group of four human SIRT proteins; n=1; Aspergillus
niger|Rep: Remark: the H. sapiens SIRT4 belongs to a
group of four human SIRT proteins - Aspergillus niger
Length = 357
Score = 62.9 bits (146), Expect = 7e-09
Identities = 47/154 (30%), Positives = 69/154 (44%), Gaps = 24/154 (15%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSE-KVIELHGTSYLVQCLKCPYEIDRHE 431
N TH I+++ KG ++S+VTQNVD H A E +ELHG C+ C ++ R E
Sbjct: 122 NSTHWAIKDIGTKGYISSVVTQNVDSFHSVAHPELPTLELHGYLRSAVCINCRTQVPRDE 181
Query: 432 LQE--------------------ILTENNPDMESSFSM-IRPDGDVDCRGNK*KNSELHS 548
Q+ L +NP+ + + I PDGDVD +
Sbjct: 182 FQQSLERLNPAWAEFLKKMVDIGALNADNPEEQRRRGLKINPDGDVDLPEAPYSTFRYPA 241
Query: 549 A-QSVKGPLKPDIVFFGDNV-PQYRVGTSQKRSD 644
S G LKP ++ FG+N+ P R+G + D
Sbjct: 242 CPTSTAGILKPAVIMFGENIDPAVRLGAEEAIDD 275
Score = 56.4 bits (130), Expect = 6e-07
Identities = 23/54 (42%), Positives = 32/54 (59%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
G+ DYR E+ ++PI Y EFV + R+RYWAR++IGWP +P S
Sbjct: 70 GLSDYRGENGTYITNKTYRPIYYHEFVARHEFRKRYWARSFIGWPGLLKAKPNS 123
>UniRef50_O07595 Cluster: NAD-dependent deacetylase; n=3;
Bacillus|Rep: NAD-dependent deacetylase - Bacillus
subtilis
Length = 247
Score = 62.9 bits (146), Expect = 7e-09
Identities = 34/84 (40%), Positives = 47/84 (55%)
Frame = +3
Query: 213 KKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLV 392
K+L+++ N HL + ELEK+GK I TQN+D LH KAGS V ELHG+ +
Sbjct: 65 KELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNIDGLHKKAGSRHVYELHGS---I 121
Query: 393 QCLKCPYEIDRHELQEILTENNPD 464
Q CP R++L +L P+
Sbjct: 122 QTAACPACGARYDLPHLLEREVPE 145
>UniRef50_A4J646 Cluster: Silent information regulator protein Sir2;
n=2; Peptococcaceae|Rep: Silent information regulator
protein Sir2 - Desulfotomaculum reducens MI-1
Length = 256
Score = 56.4 bits (130), Expect(2) = 8e-09
Identities = 25/64 (39%), Positives = 36/64 (56%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + LEK G + ++TQN+D LH AGS++V E+HG CL C + D +L
Sbjct: 83 NNAHFALARLEKMGWLLGVITQNIDGLHQHAGSKRVWEVHGNLKGCSCLSCKKQFDMGQL 142
Query: 435 QEIL 446
+ L
Sbjct: 143 HKQL 146
Score = 26.2 bits (55), Expect(2) = 8e-09
Identities = 9/16 (56%), Positives = 13/16 (81%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPQ 611
G L+PD+V FGD +P+
Sbjct: 153 GLLRPDVVLFGDAMPE 168
>UniRef50_A6P1S7 Cluster: Putative uncharacterized protein; n=2;
Bacteria|Rep: Putative uncharacterized protein -
Bacteroides capillosus ATCC 29799
Length = 262
Score = 62.1 bits (144), Expect = 1e-08
Identities = 27/51 (52%), Positives = 36/51 (70%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKC 407
N H + ELE+ GK+T++VTQN+D LH KAGS+ V+ELHG+ C KC
Sbjct: 102 NAAHKKLAELEQAGKLTAMVTQNIDGLHQKAGSKNVLELHGSVLRNYCEKC 152
>UniRef50_UPI000049971A Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 285
Score = 61.7 bits (143), Expect = 2e-08
Identities = 27/53 (50%), Positives = 35/53 (66%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPY 413
N H + ELEK G V +IVTQNVD LH +AGS+ V+E+HG+ C+ C Y
Sbjct: 98 NHVHEALAELEKIGVVKTIVTQNVDGLHQQAGSKNVVEMHGSGRACYCIDCDY 150
>UniRef50_A1I9S7 Cluster: NAD-dependent deacetylase; n=1; Candidatus
Desulfococcus oleovorans Hxd3|Rep: NAD-dependent
deacetylase - Candidatus Desulfococcus oleovorans Hxd3
Length = 273
Score = 61.7 bits (143), Expect = 2e-08
Identities = 29/96 (30%), Positives = 50/96 (52%)
Frame = +3
Query: 120 GGCWSVCP**SQTYTVSRICEVSESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKKGK 299
GG W T + + ++ K++ + LA N H + +LE+ G
Sbjct: 41 GGVWDRLNPAEVGDTQGLLASLEKNPEKLVAMFMELLAVFDAAIPNPGHRALFDLERMGI 100
Query: 300 VTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKC 407
+ +++TQN+D LH +AG+ +VIE+HG + +CLKC
Sbjct: 101 LQAVITQNIDNLHQEAGNTQVIEMHGNGFRFRCLKC 136
>UniRef50_O94640 Cluster: NAD-dependent histone deacetylase sir2;
n=1; Schizosaccharomyces pombe|Rep: NAD-dependent
histone deacetylase sir2 - Schizosaccharomyces pombe
(Fission yeast)
Length = 475
Score = 61.7 bits (143), Expect = 2e-08
Identities = 38/125 (30%), Positives = 63/125 (50%), Gaps = 9/125 (7%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
+H IR LEKK K++++ TQN+D L K G K+I+ HG+ C+KC +++D EL
Sbjct: 227 SHAFIRLLEKKNKLSTLFTQNIDNLEKKTGLSDNKIIQCHGSFATATCIKCKHKVDGSEL 286
Query: 435 QEILTENNPDMESSFS----MIRPDGDVDCRGNK*KNSELHSAQ---SVKGPLKPDIVFF 593
E + + +R G + + + S++ + G +KPDI FF
Sbjct: 287 YEDIRNQRVSYCNECGKPPLKLRRVGQNKKEKHYFSDGDSESSEDDLAQPGIMKPDITFF 346
Query: 594 GDNVP 608
G+ +P
Sbjct: 347 GEALP 351
>UniRef50_A0LG97 Cluster: Silent information regulator protein Sir2;
n=1; Syntrophobacter fumaroxidans MPOB|Rep: Silent
information regulator protein Sir2 - Syntrophobacter
fumaroxidans (strain DSM 10017 / MPOB)
Length = 248
Score = 61.3 bits (142), Expect = 2e-08
Identities = 26/59 (44%), Positives = 39/59 (66%)
Frame = +3
Query: 231 AEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKC 407
A ++ N HL + +LEK+G V +VTQN+D LH +AGS+ VIE HG + ++C +C
Sbjct: 71 AVLRQARPNFAHLALADLEKRGIVKELVTQNIDSLHQRAGSKNVIEFHGHNRSLRCDRC 129
>UniRef50_A1FG80 Cluster: Silent information regulator protein Sir2;
n=3; Pseudomonas|Rep: Silent information regulator
protein Sir2 - Pseudomonas putida W619
Length = 252
Score = 60.1 bits (139), Expect = 5e-08
Identities = 26/73 (35%), Positives = 41/73 (56%)
Frame = +3
Query: 189 ESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIE 368
E+ A V G L+R ++ N H I L G+ ++VTQN+D LH +AG+++V+
Sbjct: 58 ENPALVWGWYLWRRQQVMQAKPNAAHQAIHRLSGSGRSVTVVTQNIDDLHERAGNQEVLH 117
Query: 369 LHGTSYLVQCLKC 407
LHG+ +C C
Sbjct: 118 LHGSLMRPKCFAC 130
>UniRef50_Q2U9Y7 Cluster: Sirtuin 4 and related class II sirtuins;
n=10; Pezizomycotina|Rep: Sirtuin 4 and related class II
sirtuins - Aspergillus oryzae
Length = 407
Score = 60.1 bits (139), Expect = 5e-08
Identities = 32/70 (45%), Positives = 41/70 (58%), Gaps = 1/70 (1%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSE-KVIELHGTSYLVQCLKCPYEIDRHE 431
N TH IR+L KG ++S+VTQNVD H A S+ IELHG V C+ C + R E
Sbjct: 149 NSTHWAIRDLGAKGYLSSVVTQNVDSFHPIAHSKLSTIELHGYLRSVVCISCQNQFPRDE 208
Query: 432 LQEILTENNP 461
Q+ L + NP
Sbjct: 209 FQKSLEKLNP 218
Score = 55.6 bits (128), Expect = 1e-06
Identities = 21/54 (38%), Positives = 33/54 (61%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
G+ DYR E+ ++PI + EF+K + R+RYWAR+++GWP +P S
Sbjct: 97 GLSDYRGENGTYVTNKTYRPIYFHEFLKRHEFRKRYWARSFVGWPGLVKAKPNS 150
>UniRef50_Q21921 Cluster: NAD-dependent deacetylase SIR2 homolog;
n=2; Caenorhabditis|Rep: NAD-dependent deacetylase SIR2
homolog - Caenorhabditis elegans
Length = 607
Score = 55.6 bits (128), Expect(2) = 5e-08
Identities = 23/62 (37%), Positives = 39/62 (62%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
+V+H I+ELE G++ TQN+D L H+ G ++V+E HG+ C +C + D +E+
Sbjct: 216 SVSHRFIKELETSGRLLRNYTQNIDTLEHQTGIKRVVECHGSFSKCTCTRCGQKYDGNEI 275
Query: 435 QE 440
+E
Sbjct: 276 RE 277
Score = 24.2 bits (50), Expect(2) = 5e-08
Identities = 8/15 (53%), Positives = 14/15 (93%)
Frame = +3
Query: 561 KGPLKPDIVFFGDNV 605
+G +KP+IVFFG+++
Sbjct: 291 EGVIKPNIVFFGEDL 305
>UniRef50_O96505 Cluster: SIR2; n=4; Sophophora|Rep: SIR2 -
Drosophila melanogaster (Fruit fly)
Length = 823
Score = 59.7 bits (138), Expect = 7e-08
Identities = 37/116 (31%), Positives = 56/116 (48%), Gaps = 1/116 (0%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQ-E 440
H I+ LE KGK+ TQN+D L AG ++VIE HG+ C KC ++ + L+ +
Sbjct: 295 HRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVIECHGSFSTASCTKCRFKCNADALRAD 354
Query: 441 ILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
I + P +P+ + + E G +KPDIVFFG+ +P
Sbjct: 355 IFAQRIP----VCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLP 406
>UniRef50_A2Q9C4 Cluster: Contig An01c0250, complete genome; n=18;
Pezizomycotina|Rep: Contig An01c0250, complete genome -
Aspergillus niger
Length = 495
Score = 59.7 bits (138), Expect = 7e-08
Identities = 40/130 (30%), Positives = 63/130 (48%), Gaps = 14/130 (10%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH IR L+ KGK+ + TQN+D + AG E +++ HG+ C+KC Y++ E+
Sbjct: 250 THAFIRVLQDKGKLLTNYTQNIDNIEANAGVLPENIVQCHGSFATATCVKCQYKVKGDEI 309
Query: 435 -QEILTENNPDMESSFSMIRPDGDVDCRGNK---*KNSELHSAQS--------VKGPLKP 578
EI P +S I D + + + KN + + S G +KP
Sbjct: 310 FDEIKKGVIPQCDSCRKRIAEDSGIKRKRSSNGVHKNRKDNDGDSTDDDYEIPTPGVMKP 369
Query: 579 DIVFFGDNVP 608
DI FFG+++P
Sbjct: 370 DITFFGEDLP 379
Score = 33.5 bits (73), Expect = 5.1
Identities = 13/20 (65%), Positives = 17/20 (85%)
Frame = +1
Query: 94 SLGIPDYRSEDVGLYARSNH 153
SLGIPD+RS+D GLY++ H
Sbjct: 192 SLGIPDFRSKDTGLYSQLAH 211
>UniRef50_Q3F1F4 Cluster: SIR2 family protein; n=1; Bacillus
thuringiensis serovar israelensis ATCC 35646|Rep: SIR2
family protein - Bacillus thuringiensis serovar
israelensis ATCC 35646
Length = 241
Score = 59.3 bits (137), Expect = 9e-08
Identities = 27/66 (40%), Positives = 39/66 (59%)
Frame = +3
Query: 225 RLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLK 404
R+ +I C N H + + E++GKV S++TQN+D H AGS+ VIE+HG + C
Sbjct: 65 RMNDISNCKPNKAHEILAKWEEQGKVKSVITQNIDSYHKDAGSKNVIEMHGHLRNLVCDT 124
Query: 405 CPYEID 422
C E D
Sbjct: 125 CSKEYD 130
>UniRef50_Q8CNF4 Cluster: NAD-dependent deacetylase; n=17;
Staphylococcus|Rep: NAD-dependent deacetylase -
Staphylococcus epidermidis (strain ATCC 12228)
Length = 246
Score = 59.3 bits (137), Expect = 9e-08
Identities = 30/81 (37%), Positives = 44/81 (54%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N+ H I +LE + K ++TQN+D LH AGS + ELHGT C+ C YE +
Sbjct: 85 NIVHQWIAQLENQQKSLGVITQNIDGLHEDAGSHNIDELHGTLNRFYCINC-YE--EYSK 141
Query: 435 QEILTENNPDMESSFSMIRPD 497
++T + E ++IRPD
Sbjct: 142 SYVMTHHLKYCEKCGNVIRPD 162
>UniRef50_Q8F3Z6 Cluster: NAD-dependent deacetylase; n=4;
Leptospira|Rep: NAD-dependent deacetylase - Leptospira
interrogans
Length = 246
Score = 59.3 bits (137), Expect = 9e-08
Identities = 31/92 (33%), Positives = 50/92 (54%)
Frame = +3
Query: 219 LYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQC 398
L+R I+ N H + ELE+ ++TQNVD LH +AGS+K+ E+HG ++ +C
Sbjct: 65 LWRRNIIETKRPNPGHFALVELERIHPDFFLITQNVDGLHSQAGSKKLTEIHGNIFINRC 124
Query: 399 LKCPYEIDRHELQEILTENNPDMESSFSMIRP 494
+ C E + + E T P ++ S +RP
Sbjct: 125 ISCGQE-SKETISENTTPLPPQCQNCNSFLRP 155
>UniRef50_Q97MB4 Cluster: NAD-dependent deacetylase; n=7;
Bacteria|Rep: NAD-dependent deacetylase - Clostridium
acetobutylicum
Length = 245
Score = 59.3 bits (137), Expect = 9e-08
Identities = 28/81 (34%), Positives = 46/81 (56%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + ++E++GK+ +IVTQN+D LH AGS+ V ELHG+ + C+ C D +
Sbjct: 86 NAAHYSLAKIEEQGKLKAIVTQNIDGLHQLAGSKNVYELHGSIHRNYCMDCGKSFDLEYV 145
Query: 435 QEILTENNPDMESSFSMIRPD 497
+ T P + +++PD
Sbjct: 146 IKSET-TIPKCDKCGGIVKPD 165
>UniRef50_Q4WET3 Cluster: SIR2 family histone deacetylase, putative;
n=4; Pezizomycotina|Rep: SIR2 family histone
deacetylase, putative - Aspergillus fumigatus (Sartorya
fumigata)
Length = 381
Score = 58.8 bits (136), Expect = 1e-07
Identities = 33/70 (47%), Positives = 38/70 (54%), Gaps = 1/70 (1%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSE-KVIELHGTSYLVQCLKCPYEIDRHE 431
N TH IR+L KG V+S+VTQNVD H A E IELHG V C C + R E
Sbjct: 122 NSTHWAIRDLAAKGFVSSVVTQNVDSFHSIAHPELPTIELHGHLKSVVCTSCRNQFSRAE 181
Query: 432 LQEILTENNP 461
Q+ L NP
Sbjct: 182 FQKSLERLNP 191
Score = 51.6 bits (118), Expect = 2e-05
Identities = 20/54 (37%), Positives = 31/54 (57%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQPTS 261
G+ DYR E ++PI + EF+ + R+RYWAR+++GWP +P S
Sbjct: 70 GLSDYRGEKGTYVTNKFYRPIYFHEFLSRHESRKRYWARSFVGWPGLLKAEPNS 123
>UniRef50_A6LP94 Cluster: Silent information regulator protein Sir2;
n=1; Thermosipho melanesiensis BI429|Rep: Silent
information regulator protein Sir2 - Thermosipho
melanesiensis BI429
Length = 234
Score = 58.4 bits (135), Expect = 2e-07
Identities = 24/51 (47%), Positives = 35/51 (68%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKC 407
N++H + ELE+ G + ++TQN+D LH+KAGS VIELHG + C +C
Sbjct: 75 NMSHKLLAELEEMGYLLGVITQNIDDLHNKAGSRNVIELHGNATHFYCEEC 125
Score = 34.7 bits (76), Expect = 2.2
Identities = 16/43 (37%), Positives = 24/43 (55%)
Frame = +1
Query: 94 SLGIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNY 222
S GIPD+RSED GLY ++ Y+ F +P + Y + +
Sbjct: 25 SSGIPDFRSED-GLYKEYGYELFSYEFFKNHPDIFYEYIKKEF 66
>UniRef50_Q88BY5 Cluster: NAD-dependent deacetylase; n=9;
Bacteria|Rep: NAD-dependent deacetylase - Pseudomonas
putida (strain KT2440)
Length = 262
Score = 57.2 bits (132), Expect = 4e-07
Identities = 29/74 (39%), Positives = 41/74 (55%), Gaps = 2/74 (2%)
Frame = +3
Query: 219 LYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQC 398
L+R ++ N HL I +L G S+VTQN+D LH +AGS V+ LHG+ V+C
Sbjct: 68 LWRRHQVSQAKPNSAHLSIPQLADAGWDVSVVTQNIDDLHERAGSSPVVHLHGSLMDVKC 127
Query: 399 LKC--PYEIDRHEL 434
C P E+ +L
Sbjct: 128 FGCHRPAELSPDQL 141
>UniRef50_Q899G3 Cluster: NAD-dependent deacetylase; n=19; cellular
organisms|Rep: NAD-dependent deacetylase - Clostridium
tetani
Length = 247
Score = 57.2 bits (132), Expect = 4e-07
Identities = 32/83 (38%), Positives = 45/83 (54%), Gaps = 2/83 (2%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N+ H + +LEK GK+ +I+TQN+D LH AGS+ VIELHG C+ C D L
Sbjct: 83 NLAHHALAKLEKVGKLKAIITQNIDGLHQLAGSKNVIELHGGVGRNYCMDCNKFFD---L 139
Query: 435 QEILTENN--PDMESSFSMIRPD 497
IL P + +++PD
Sbjct: 140 NYILNNKEVVPKCDVCGGIVKPD 162
>UniRef50_Q3A6W7 Cluster: NAD-dependent protein deacetylases, SIR2
family; n=2; Pelobacter|Rep: NAD-dependent protein
deacetylases, SIR2 family - Pelobacter carbinolicus
(strain DSM 2380 / Gra Bd 1)
Length = 278
Score = 56.8 bits (131), Expect = 5e-07
Identities = 25/49 (51%), Positives = 32/49 (65%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKC 407
TH + LEK G + ++TQN+D LH AGS KVI+LHG+ QCL C
Sbjct: 101 THRFLAGLEKAGGLAGLITQNIDMLHQLAGSRKVIDLHGSYRSAQCLFC 149
>UniRef50_Q5BVX8 Cluster: SJCHGC08739 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC08739 protein - Schistosoma
japonicum (Blood fluke)
Length = 179
Score = 56.8 bits (131), Expect = 5e-07
Identities = 28/66 (42%), Positives = 39/66 (59%), Gaps = 4/66 (6%)
Frame = +3
Query: 222 YRLAEIQLCATNVTHLCIRELEK----KGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYL 389
+R I+L N HL + + EK G+ ++TQNVD LH KAGS ++ELHG Y
Sbjct: 106 HRRETIRLRQPNSGHLALAQAEKLYVDSGRSFFVITQNVDDLHAKAGSGNILELHGNVYK 165
Query: 390 VQCLKC 407
+CL+C
Sbjct: 166 TRCLEC 171
>UniRef50_Q9NTG7 Cluster: NAD-dependent deacetylase sirtuin-3,
mitochondrial precursor; n=22; Euteleostomi|Rep:
NAD-dependent deacetylase sirtuin-3, mitochondrial
precursor - Homo sapiens (Human)
Length = 399
Score = 47.2 bits (107), Expect(2) = 6e-07
Identities = 24/84 (28%), Positives = 42/84 (50%), Gaps = 3/84 (3%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRH 428
NVTH +R L KG + + TQN+D L +G + K++E HGT C C
Sbjct: 207 NVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGE 266
Query: 429 ELQ-EILTENNPDMESSFSMIRPD 497
+++ +++ + P +++PD
Sbjct: 267 DIRADVMADRVPRCPVCTGVVKPD 290
Score = 29.1 bits (62), Expect(2) = 6e-07
Identities = 11/16 (68%), Positives = 14/16 (87%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPQ 611
G +KPDIVFFG+ +PQ
Sbjct: 285 GVVKPDIVFFGEPLPQ 300
>UniRef50_UPI00015B57C0 Cluster: PREDICTED: similar to GA18743-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
GA18743-PA - Nasonia vitripennis
Length = 871
Score = 56.4 bits (130), Expect = 6e-07
Identities = 35/116 (30%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQ-E 440
H I+ LEK+ K+ +QN+D L AG +IE HG+ C KC Y++ +++ E
Sbjct: 278 HQFIKMLEKQKKLLRNYSQNIDTLERVAGINNLIECHGSFATASCTKCKYQVKSDDVKAE 337
Query: 441 ILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
I + P P +S+ + +G +KPDIVFFG+ +P
Sbjct: 338 IFAQTIPMCPKCQEQSLPS------ITDPTSSDNYRDIVAQGVMKPDIVFFGEGLP 387
>UniRef50_A3ZMQ7 Cluster: Sir2 family, possible ADP
ribosyltransferase; n=1; Blastopirellula marina DSM
3645|Rep: Sir2 family, possible ADP ribosyltransferase -
Blastopirellula marina DSM 3645
Length = 252
Score = 56.4 bits (130), Expect = 6e-07
Identities = 33/103 (32%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Frame = +3
Query: 120 GGCWSVCP**SQTYTVSRICEVSESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKKGK 299
GG W+ +T + +E++ + +K E A N H + E G
Sbjct: 41 GGVWTKY----RTIYFDEFRQSAEARREYWRQKSEAHVEFSAAAPNAGHQILAAWEAHGV 96
Query: 300 VTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCP--YEID 422
++TQN+D LH AGS +V+ELHGT+ CL C +EID
Sbjct: 97 ARGLITQNIDGLHQIAGSRQVLELHGTAREATCLDCAARFEID 139
>UniRef50_Q5V4Q5 Cluster: NAD-dependent deacetylase; n=2;
Halobacteriaceae|Rep: NAD-dependent deacetylase -
Haloarcula marismortui (Halobacterium marismortui)
Length = 260
Score = 56.4 bits (130), Expect = 6e-07
Identities = 29/83 (34%), Positives = 44/83 (53%), Gaps = 2/83 (2%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + LE G + +++TQN+D LH AG+++V+ELHGT V C C + D +
Sbjct: 93 NAAHEALAALEADGHLDAVLTQNIDGLHDAAGTDRVVELHGTHRRVVCDDCGHRRDAEVV 152
Query: 435 QEILTENN--PDMESSFSMIRPD 497
E E++ P + RPD
Sbjct: 153 FEQAAESSDLPPRCDCGGVYRPD 175
>UniRef50_A6TNA0 Cluster: Silent information regulator protein Sir2;
n=1; Alkaliphilus metalliredigens QYMF|Rep: Silent
information regulator protein Sir2 - Alkaliphilus
metalliredigens QYMF
Length = 249
Score = 55.6 bits (128), Expect = 1e-06
Identities = 25/51 (49%), Positives = 32/51 (62%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYE 416
H + +LEKKG + SI TQNV LH AGS+ V ELHG ++C C +E
Sbjct: 92 HYILSDLEKKGMIRSIATQNVAGLHVMAGSQNVYELHGNIRKIRCNNCNHE 142
>UniRef50_Q7RP35 Cluster: Sir2-like protein; n=5; Plasmodium
(Vinckeia)|Rep: Sir2-like protein - Plasmodium yoelii
yoelii
Length = 1159
Score = 55.6 bits (128), Expect = 1e-06
Identities = 23/79 (29%), Positives = 45/79 (56%), Gaps = 2/79 (2%)
Frame = +3
Query: 177 CEVSESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSE 356
C+ S+ G + ++ E+ L TH+ I+EL K + ++TQN+D LH++ G++
Sbjct: 212 CQSSDENYVKFGNRKKKVVELHLALPTKTHIMIKELMNKNIIKFLITQNIDSLHYRCGTK 271
Query: 357 --KVIELHGTSYLVQCLKC 407
++ E+HG ++ +C C
Sbjct: 272 FSQISEIHGNIFIERCDFC 290
>UniRef50_Q8REC3 Cluster: NAD-dependent deacetylase; n=3;
Fusobacterium nucleatum|Rep: NAD-dependent deacetylase -
Fusobacterium nucleatum subsp. nucleatum
Length = 252
Score = 55.6 bits (128), Expect = 1e-06
Identities = 24/58 (41%), Positives = 37/58 (63%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRH 428
N H+ + ELEK G + +++TQN+D LH +G++ V+ELHG+ CL C DR+
Sbjct: 88 NKGHMALVELEKIGILKAVITQNIDDLHQVSGNKNVLELHGSLKRWYCLSCGKTADRN 145
>UniRef50_Q67KQ0 Cluster: NAD-dependent deacetylase; n=1;
Symbiobacterium thermophilum|Rep: NAD-dependent
deacetylase - Symbiobacterium thermophilum
Length = 251
Score = 55.2 bits (127), Expect = 1e-06
Identities = 24/51 (47%), Positives = 33/51 (64%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKC 407
N H + L+++G + ++TQNVD LH AGS VIELHG+ QCL+C
Sbjct: 80 NPVHKVLAALQREGLLKRLITQNVDGLHQAAGSPDVIELHGSLRECQCLRC 130
>UniRef50_Q8IKW2 Cluster: Putative uncharacterized protein; n=1;
Plasmodium falciparum 3D7|Rep: Putative uncharacterized
protein - Plasmodium falciparum (isolate 3D7)
Length = 1304
Score = 54.8 bits (126), Expect = 2e-06
Identities = 24/70 (34%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Frame = +3
Query: 204 VLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGS--EKVIELHG 377
+ GK+ ++ E+ L + TH+ I EL K + ++TQN+D LHH+ G K E+HG
Sbjct: 236 IFGKRKKKVIELHLALPSKTHIMINELINKNIIKFMITQNIDSLHHRCGKHFSKTAEIHG 295
Query: 378 TSYLVQCLKC 407
+ +C C
Sbjct: 296 NIFTERCDFC 305
>UniRef50_Q4UH74 Cluster: Sir2-like histone deacetylase, putative;
n=2; Theileria|Rep: Sir2-like histone deacetylase,
putative - Theileria annulata
Length = 928
Score = 54.8 bits (126), Expect = 2e-06
Identities = 27/75 (36%), Positives = 43/75 (57%), Gaps = 2/75 (2%)
Frame = +3
Query: 210 GKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTS 383
G ++ E L + +HLC+ EL ++ K+ I+TQNVD LH +G +K+ ELHG
Sbjct: 175 GNNKRKIVEFILALPSESHLCLLELLRRKKIRYIITQNVDGLHAVSGIPFDKLSELHGNV 234
Query: 384 YLVQCLKCPYEIDRH 428
++ +CL C R+
Sbjct: 235 FVQRCLFCHKRYQRN 249
>UniRef50_UPI0000E49846 Cluster: PREDICTED: similar to Sirtuin
(silent mating type information regulation 2 homolog) 6
(S. cerevisiae); n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to Sirtuin (silent mating type
information regulation 2 homolog) 6 (S. cerevisiae) -
Strongylocentrotus purpuratus
Length = 521
Score = 54.0 bits (124), Expect = 3e-06
Identities = 23/68 (33%), Positives = 40/68 (58%), Gaps = 2/68 (2%)
Frame = +3
Query: 210 GKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTS 383
GKK TH+ + ELE++GK+ +++QN+D LH ++G +++ ELHG
Sbjct: 23 GKKPEANVTFDTAKPTATHMALVELERRGKLQYLISQNIDGLHLRSGFPKDRLAELHGNM 82
Query: 384 YLVQCLKC 407
++ QC +C
Sbjct: 83 FVEQCHRC 90
>UniRef50_Q5P3W1 Cluster: NAD-dependent deacetylase 2; n=4;
Proteobacteria|Rep: NAD-dependent deacetylase 2 -
Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum
(strain EbN1))
Length = 260
Score = 54.0 bits (124), Expect = 3e-06
Identities = 27/79 (34%), Positives = 45/79 (56%), Gaps = 1/79 (1%)
Frame = +3
Query: 180 EVSESKAKVLGKKLYRL-AEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSE 356
E+ E+ +V K + + A + A N+ H I LE + ++TQNVD LH AGS
Sbjct: 62 EMMEAHPEVAWKYIAEIEANCRGAAPNIAHRIIAALEHERPGVWVLTQNVDGLHRAAGSR 121
Query: 357 KVIELHGTSYLVQCLKCPY 413
+IE+HG+ + ++C +C +
Sbjct: 122 NLIEIHGSVHRLRCTECKH 140
>UniRef50_A7B9E8 Cluster: Putative uncharacterized protein; n=1;
Actinomyces odontolyticus ATCC 17982|Rep: Putative
uncharacterized protein - Actinomyces odontolyticus ATCC
17982
Length = 251
Score = 54.0 bits (124), Expect = 3e-06
Identities = 27/81 (33%), Positives = 40/81 (49%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + LE G++ +++TQN+D LH +AGS V ELHG + C C +
Sbjct: 80 NGAHRALASLEAAGRLDAVITQNIDGLHQRAGSRAVWELHGNWERLVCTSCGAVASLGDS 139
Query: 435 QEILTENNPDMESSFSMIRPD 497
+ + P S S +RPD
Sbjct: 140 VRVDGDPVPACPSCASQMRPD 160
>UniRef50_A1HU63 Cluster: Silent information regulator protein Sir2;
n=1; Thermosinus carboxydivorans Nor1|Rep: Silent
information regulator protein Sir2 - Thermosinus
carboxydivorans Nor1
Length = 243
Score = 54.0 bits (124), Expect = 3e-06
Identities = 30/89 (33%), Positives = 45/89 (50%), Gaps = 2/89 (2%)
Frame = +3
Query: 237 IQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYE 416
I + N H+ + L KG + ++TQN+D LH +AG+ V ELHG Y C++C E
Sbjct: 73 ILAASPNAAHIGLARLLAKGVLRGLMTQNIDGLHSRAGAGVVWELHGNLYRGYCMECRTE 132
Query: 417 IDRH-ELQEILTENN-PDMESSFSMIRPD 497
D + L L P +++RPD
Sbjct: 133 YDMNGPLAAFLQRGQIPTSACCGAVLRPD 161
>UniRef50_UPI00006CB0CC Cluster: transcriptional regulator, Sir2
family protein; n=1; Tetrahymena thermophila SB210|Rep:
transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 442
Score = 53.6 bits (123), Expect = 4e-06
Identities = 30/81 (37%), Positives = 47/81 (58%), Gaps = 3/81 (3%)
Frame = +3
Query: 180 EVSESKAKVLGKKLYRLAEIQLCA-TNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG-- 350
E+ E+K K L +K + + A + TH+ I +L K+ + S++TQNVD LHH++G
Sbjct: 104 ELEENKKKFLEEKGKPQIILAINAFPSPTHMAISKLYKENLIKSVITQNVDNLHHQSGIP 163
Query: 351 SEKVIELHGTSYLVQCLKCPY 413
+ + ELHG +C KC Y
Sbjct: 164 RKDIHELHGNIISERCEKCNY 184
>UniRef50_Q0LFI4 Cluster: Silent information regulator protein Sir2;
n=1; Herpetosiphon aurantiacus ATCC 23779|Rep: Silent
information regulator protein Sir2 - Herpetosiphon
aurantiacus ATCC 23779
Length = 171
Score = 53.6 bits (123), Expect = 4e-06
Identities = 23/48 (47%), Positives = 32/48 (66%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQC 398
N H+ + +LE+ +I+TQN+D LH +AGS +VIELHGT V C
Sbjct: 7 NAGHVALAQLEQHIPSVTIITQNIDGLHQRAGSTRVIELHGTINTVSC 54
>UniRef50_Q0AY57 Cluster: Regulatory protein, sir2 family; n=1;
Syntrophomonas wolfei subsp. wolfei str. Goettingen|Rep:
Regulatory protein, sir2 family - Syntrophomonas wolfei
subsp. wolfei (strain Goettingen)
Length = 253
Score = 53.6 bits (123), Expect = 4e-06
Identities = 23/45 (51%), Positives = 30/45 (66%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQC 398
H + E+EK G + +IVTQN+D LH KAGS+KVI +HG C
Sbjct: 85 HQVLAEMEKAGIIKAIVTQNIDNLHQKAGSQKVIPIHGNGARFLC 129
>UniRef50_A1A3R7 Cluster: Sir2-type regulatory protein; n=2;
Bifidobacterium adolescentis|Rep: Sir2-type regulatory
protein - Bifidobacterium adolescentis (strain ATCC
15703 / DSM 20083)
Length = 218
Score = 53.6 bits (123), Expect = 4e-06
Identities = 38/126 (30%), Positives = 59/126 (46%), Gaps = 2/126 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H + +LE+ G +T + TQN D LH KAG S ++ LHGT C+KC + D E+
Sbjct: 37 HKALVKLEQAGLLTLLATQNFDALHEKAGNSSNVIVNLHGTIGTSHCMKCHAKYDTAEIM 96
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQYR 617
L +N PD + G++ C G +K D+V+FG+ +P
Sbjct: 97 ANL-DNEPDPHCH-RKLPYSGNMPC----------------DGLIKTDVVYFGEALPDGA 138
Query: 618 VGTSQK 635
+ S +
Sbjct: 139 IEKSYR 144
>UniRef50_A7RMK8 Cluster: Predicted protein; n=5; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 273
Score = 53.6 bits (123), Expect = 4e-06
Identities = 28/63 (44%), Positives = 35/63 (55%), Gaps = 4/63 (6%)
Frame = +3
Query: 222 YRLAEIQLCATNVTHLCIRELEKK----GKVTSIVTQNVDXLHHKAGSEKVIELHGTSYL 389
YR + N H I E +KK GK +VTQN+D LH AG+E VIELHGT +
Sbjct: 79 YRREVVLSKKPNPAHFAIAEFQKKMRNEGKQVWVVTQNIDELHKTAGAEDVIELHGTLFK 138
Query: 390 VQC 398
+C
Sbjct: 139 TRC 141
>UniRef50_A7EC18 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 446
Score = 53.6 bits (123), Expect = 4e-06
Identities = 32/88 (36%), Positives = 49/88 (55%), Gaps = 2/88 (2%)
Frame = +3
Query: 204 VLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHG 377
VL K+LY Q T ++H + +EKKG + + TQN+D L +AG SEKVIE HG
Sbjct: 93 VLAKELY---PGQFYPT-ISHAFVALIEKKGLLRMLFTQNIDCLERRAGVSSEKVIEAHG 148
Query: 378 TSYLVQCLKCPYEIDRHELQEILTENNP 461
+ +C+ C E +++ + E +P
Sbjct: 149 SFATQRCIDCKTEYPDDMMKKAIQEGDP 176
>UniRef50_UPI0000D578DC Cluster: PREDICTED: similar to sirtuin 5
(silent mating type information regulation 2 homolog) 5;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
sirtuin 5 (silent mating type information regulation 2
homolog) 5 - Tribolium castaneum
Length = 254
Score = 53.2 bits (122), Expect = 6e-06
Identities = 43/124 (34%), Positives = 62/124 (50%), Gaps = 7/124 (5%)
Frame = +3
Query: 255 NVTHLCIRELEK----KGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEID 422
N H + + EK +G+ ++TQNVD LH +AGSE V+ELHG+ V C KC
Sbjct: 84 NNAHKALAKYEKICKEQGRQFHVITQNVDGLHKRAGSENVLELHGSLDKVICTKC----- 138
Query: 423 RHELQEILTENNPDMESSFSMIRPDGDVDCRGNK---*KNSELHSAQSVKGPLKPDIVFF 593
+ E+ TE NP E+ +R GD R EL + ++P IV+F
Sbjct: 139 --KQIEVNTE-NPICEA----LRGRGDPSKRDQDLPIIPLEELPKCSECQALVRPYIVWF 191
Query: 594 GDNV 605
G+N+
Sbjct: 192 GENL 195
>UniRef50_Q07FY7 Cluster: Sirtuin (Silent mating type information
regulation 2 homolog) 3; n=3; Xenopus|Rep: Sirtuin
(Silent mating type information regulation 2 homolog) 3
- Xenopus tropicalis (Western clawed frog) (Silurana
tropicalis)
Length = 401
Score = 53.2 bits (122), Expect = 6e-06
Identities = 38/121 (31%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGS--EKVIELHGTSYLVQCLKCPYEIDRH 428
N+ H I+ L KG + TQN+D L AG EK++E+HGT + C C +
Sbjct: 196 NLVHYFIKLLHDKGLLLRCYTQNIDGLERLAGIPVEKIVEVHGTFFSASCSLCYTPFPAN 255
Query: 429 ELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
E +E++ DG+ C + GP+KPDIVFFG+++P
Sbjct: 256 EAKELIF---------------DGNPPC------------CKFCAGPVKPDIVFFGEDLP 288
Query: 609 Q 611
Q
Sbjct: 289 Q 289
>UniRef50_A5AF92 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 343
Score = 53.2 bits (122), Expect = 6e-06
Identities = 23/58 (39%), Positives = 38/58 (65%), Gaps = 2/58 (3%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEID 422
++TH+ + ELEK G + +++QN+D LH ++G +K+ ELHG S++ C C E D
Sbjct: 124 SMTHMALVELEKAGILKFVISQNIDGLHLRSGIPRDKLAELHGNSFMEICSSCGIEYD 181
>UniRef50_A4QX96 Cluster: Putative uncharacterized protein; n=2;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 534
Score = 45.2 bits (102), Expect(2) = 7e-06
Identities = 23/86 (26%), Positives = 43/86 (50%), Gaps = 3/86 (3%)
Frame = +3
Query: 249 ATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEID 422
A ++H + L +KG + + TQN+D L AG + V+E HG+ +C+ C E
Sbjct: 103 APTISHAFVALLARKGLLAMLFTQNIDGLEKAAGVPPDLVVEAHGSFDSQRCIDCAQEFP 162
Query: 423 RHELQ-EILTENNPDMESSFSMIRPD 497
+++ + T + P +++PD
Sbjct: 163 AADMRAHVATSSVPHCGKCGGLVKPD 188
Score = 27.5 bits (58), Expect(2) = 7e-06
Identities = 10/15 (66%), Positives = 13/15 (86%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVP 608
G +KPDIVFFG+ +P
Sbjct: 183 GLVKPDIVFFGEQLP 197
>UniRef50_Q8G465 Cluster: Sir2-type regulatory protein; n=2;
Bifidobacterium longum|Rep: Sir2-type regulatory protein
- Bifidobacterium longum
Length = 216
Score = 52.8 bits (121), Expect = 8e-06
Identities = 30/87 (34%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEK--VIELHGTSYLVQCLKCPYEIDRHELQ 437
H + +LE+ G +T + TQN D LH KAG+ ++ LHGT C+KC E ++
Sbjct: 37 HKALVKLEQAGMLTLLATQNFDALHEKAGNSDNVIVNLHGTIGTSHCMKCHQEYATADIM 96
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRG 518
L E PD ++ GD+ C G
Sbjct: 97 ARLDE-EPD-PHCHRKLKYRGDMPCNG 121
>UniRef50_Q1RPU3 Cluster: Zinc finger protein; n=1; Ciona
intestinalis|Rep: Zinc finger protein - Ciona
intestinalis (Transparent sea squirt)
Length = 737
Score = 52.8 bits (121), Expect = 8e-06
Identities = 41/126 (32%), Positives = 57/126 (45%), Gaps = 2/126 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQEI 443
H I LEK G++ TQN+D L AG KV++ HG+ C C Y+ + EL+
Sbjct: 262 HRFISLLEKTGRLLRNYTQNIDTLEQVAGISKVVQCHGSFATASCCSCDYKTNCEELRAD 321
Query: 444 LTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQ--YR 617
+ F+ + P C G +KPDIVFFG+N+PQ +R
Sbjct: 322 I----------FNQVVP----HCP---------RCPSDDPGVIKPDIVFFGENLPQQFHR 358
Query: 618 VGTSQK 635
TS K
Sbjct: 359 QMTSDK 364
>UniRef50_A5K7T7 Cluster: NAD-dependent deacetylase, putative; n=5;
Plasmodium|Rep: NAD-dependent deacetylase, putative -
Plasmodium vivax
Length = 306
Score = 52.8 bits (121), Expect = 8e-06
Identities = 21/60 (35%), Positives = 37/60 (61%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + +LE G + +++TQN+D LH ++G+ KVI LHG+ + +C C I +++
Sbjct: 93 NPGHTALSKLESLGYLKTVITQNIDGLHEESGNSKVIPLHGSVFEARCCTCRETIQLNKI 152
>UniRef50_A6RXY5 Cluster: Putative uncharacterized protein; n=2;
Pezizomycotina|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 446
Score = 52.8 bits (121), Expect = 8e-06
Identities = 32/88 (36%), Positives = 49/88 (55%), Gaps = 2/88 (2%)
Frame = +3
Query: 204 VLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHG 377
VL K+LY Q T V+H + +EKKG + + TQN+D L +AG SEKVIE HG
Sbjct: 93 VLAKELY---PGQFYPT-VSHAFVALIEKKGLLRMLFTQNIDCLERRAGVSSEKVIEAHG 148
Query: 378 TSYLVQCLKCPYEIDRHELQEILTENNP 461
+ +C+ C E +++ + + +P
Sbjct: 149 SFATQRCIDCKTEYPDDMMKKAIEDGDP 176
>UniRef50_O25849 Cluster: NAD-dependent deacetylase; n=11;
Bacteria|Rep: NAD-dependent deacetylase - Helicobacter
pylori (Campylobacter pylori)
Length = 229
Score = 52.8 bits (121), Expect = 8e-06
Identities = 32/81 (39%), Positives = 47/81 (58%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + ELEK +V +I+TQNVD LH +AGS +++ LHG V+ K P + R E
Sbjct: 66 NKAHKALAELEKHYQV-NIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWE- 123
Query: 435 QEILTENNPDMESSFSMIRPD 497
+++ N D+ S +RPD
Sbjct: 124 KDL---NLGDLAKDKSQLRPD 141
>UniRef50_Q9JN05 Cluster: NAD-dependent deacetylase; n=13;
Campylobacter|Rep: NAD-dependent deacetylase -
Campylobacter jejuni
Length = 233
Score = 52.8 bits (121), Expect = 8e-06
Identities = 32/89 (35%), Positives = 49/89 (55%), Gaps = 4/89 (4%)
Frame = +3
Query: 153 QTYTVSRICEVS---ESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKK-GKVTSIVTQ 320
+ Y V +C + ++ KVL R A++Q N H I +L++K GK ++TQ
Sbjct: 29 EEYDVMEVCSATGFRKNPKKVLDFYDARRAQLQNVKPNHAHEKIAQLKEKWGKNLFVITQ 88
Query: 321 NVDXLHHKAGSEKVIELHGTSYLVQCLKC 407
NVD L +AG + V+ LHG ++CLKC
Sbjct: 89 NVDDLLERAGCKDVVHLHGFLPELRCLKC 117
>UniRef50_Q8R104 Cluster: NAD-dependent deacetylase sirtuin-3; n=8;
Deuterostomia|Rep: NAD-dependent deacetylase sirtuin-3 -
Mus musculus (Mouse)
Length = 257
Score = 44.4 bits (100), Expect(2) = 9e-06
Identities = 23/84 (27%), Positives = 40/84 (47%), Gaps = 3/84 (3%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRH 428
NVTH +R L K + + TQN+D L +G + K++E HGT C C
Sbjct: 65 NVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGE 124
Query: 429 EL-QEILTENNPDMESSFSMIRPD 497
++ +++ + P +++PD
Sbjct: 125 DIWADVMADRVPRCPVCTGVVKPD 148
Score = 27.9 bits (59), Expect(2) = 9e-06
Identities = 10/15 (66%), Positives = 13/15 (86%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVP 608
G +KPDIVFFG+ +P
Sbjct: 143 GVVKPDIVFFGEQLP 157
>UniRef50_A0NQ49 Cluster: Silent information regulator protein Sir2;
n=1; Stappia aggregata IAM 12614|Rep: Silent information
regulator protein Sir2 - Stappia aggregata IAM 12614
Length = 260
Score = 52.4 bits (120), Expect = 1e-05
Identities = 21/53 (39%), Positives = 31/53 (58%), Gaps = 2/53 (3%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKC 407
N H + L + GK+ ++TQNVD LH +AG + ++E+HG S CL C
Sbjct: 94 NAAHFALTTLARSGKLVCLITQNVDGLHQRAGFPDDLLVEIHGNSTFASCLSC 146
Score = 36.3 bits (80), Expect = 0.72
Identities = 20/48 (41%), Positives = 26/48 (54%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFS 243
GIPD+RS G++ S +P+QYQ+FV R W R W R S
Sbjct: 38 GIPDFRSPG-GIW--SKRQPVQYQDFVDDEDSRLEDWDRRLEDWDRRS 82
>UniRef50_A5K3P4 Cluster: Putative uncharacterized protein; n=1;
Plasmodium vivax|Rep: Putative uncharacterized protein -
Plasmodium vivax
Length = 1259
Score = 52.0 bits (119), Expect = 1e-05
Identities = 20/70 (28%), Positives = 42/70 (60%), Gaps = 2/70 (2%)
Frame = +3
Query: 204 VLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSE--KVIELHG 377
+ G + ++ ++ L TH+ I+EL + + ++TQN+D LH++ G++ K+ E+HG
Sbjct: 327 IFGNRKKKVIDLHLALPTKTHIMIKELMNRNIIKFLITQNIDSLHYRCGTKFSKISEIHG 386
Query: 378 TSYLVQCLKC 407
++ +C C
Sbjct: 387 NIFIERCDFC 396
>UniRef50_Q88ZA0 Cluster: NAD-dependent deacetylase; n=4;
Lactobacillus|Rep: NAD-dependent deacetylase -
Lactobacillus plantarum
Length = 234
Score = 52.0 bits (119), Expect = 1e-05
Identities = 23/59 (38%), Positives = 36/59 (61%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHE 431
NV H + L ++G+ S++TQN+D L+ A + +++E HG Y V C KC +D HE
Sbjct: 79 NVIHQKMAALTQQGRA-SVITQNIDNLYGVAKTAQLVEFHGNLYQVYCTKCGQHVDWHE 136
>UniRef50_Q9FE17 Cluster: Sir2-like protein; n=9; Magnoliophyta|Rep:
Sir2-like protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 473
Score = 51.2 bits (117), Expect = 2e-05
Identities = 23/56 (41%), Positives = 37/56 (66%), Gaps = 2/56 (3%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYE 416
++TH+ + ELE+ G + +++QNVD LH ++G EK+ ELHG S++ C C E
Sbjct: 93 SMTHMALVELERAGILKFVISQNVDGLHLRSGIPREKLSELHGDSFMEMCPSCGAE 148
>UniRef50_Q7SB01 Cluster: Putative uncharacterized protein
NCU07624.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU07624.1 - Neurospora crassa
Length = 437
Score = 51.2 bits (117), Expect = 2e-05
Identities = 21/69 (30%), Positives = 40/69 (57%), Gaps = 2/69 (2%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH+ + EL+++G + +++QN D LH ++G ++ + ELHG + + C C E R +
Sbjct: 85 THMALVELQERGILKGLISQNCDGLHRRSGIRADMISELHGNTNIEHCKNCGKEFLRADF 144
Query: 435 QEILTENNP 461
+ +N P
Sbjct: 145 YAVAPDNRP 153
>UniRef50_Q9NXA8 Cluster: NAD-dependent deacetylase sirtuin-5; n=28;
Coelomata|Rep: NAD-dependent deacetylase sirtuin-5 -
Homo sapiens (Human)
Length = 310
Score = 51.2 bits (117), Expect = 2e-05
Identities = 18/46 (39%), Positives = 31/46 (67%)
Frame = +3
Query: 270 CIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKC 407
C L K+G+ ++TQN+D LH KAG++ ++E+HG+ + +C C
Sbjct: 124 CETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSC 169
>UniRef50_Q8ZFR1 Cluster: NAD-dependent deacetylase; n=149; cellular
organisms|Rep: NAD-dependent deacetylase - Yersinia
pestis
Length = 278
Score = 47.6 bits (108), Expect(2) = 3e-05
Identities = 22/59 (37%), Positives = 34/59 (57%), Gaps = 1/59 (1%)
Frame = +3
Query: 249 ATNVTHLCIRELEKK-GKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEID 422
A N H + +LE G ++TQN+D LH +AGS++VI +HG V+C + +D
Sbjct: 103 APNAAHFALADLEAVLGDNLVLITQNIDNLHERAGSKRVIHMHGELLKVRCTQSGQVLD 161
Score = 23.0 bits (47), Expect(2) = 3e-05
Identities = 11/32 (34%), Positives = 18/32 (56%)
Frame = +3
Query: 504 VDCRGNK*KNSELHSAQSVKGPLKPDIVFFGD 599
+D +G+ + H Q PL+P IV+FG+
Sbjct: 160 LDWQGDLSADERCHCCQ-FPSPLRPHIVWFGE 190
>UniRef50_Q95Q89 Cluster: Yeast sir related protein 2.4; n=2;
Caenorhabditis|Rep: Yeast sir related protein 2.4 -
Caenorhabditis elegans
Length = 299
Score = 50.8 bits (116), Expect = 3e-05
Identities = 27/69 (39%), Positives = 37/69 (53%), Gaps = 2/69 (2%)
Frame = +3
Query: 234 EIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKC 407
+ Q+ V+H I L K G + +I+TQNVD L K G E +IE+HG +L C C
Sbjct: 95 DFQVARPGVSHKSILALHKAGYIKTIITQNVDGLDRKVGIPVEDLIEVHGNLFLEVCQSC 154
Query: 408 PYEIDRHEL 434
E R E+
Sbjct: 155 FSEYVREEI 163
>UniRef50_Q4P1X1 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 434
Score = 50.8 bits (116), Expect = 3e-05
Identities = 37/119 (31%), Positives = 57/119 (47%), Gaps = 2/119 (1%)
Frame = +3
Query: 258 VTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSE--KVIELHGTSYLVQCLKCPYEIDRHE 431
+ H + L++K K+ + TQNVD L AG E KV+E HG+ C+ C + +D
Sbjct: 121 LAHYFLTLLQRKQKLKRVFTQNVDTLERIAGVEADKVVEAHGSFATSTCIVCKHSVDDDW 180
Query: 432 LQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
++ N + RP C G K + + G +KPDIVFFG+++P
Sbjct: 181 IR-----NKVESGQVARCPRPK----CPGRKTGSK----GEQRGGLVKPDIVFFGESLP 226
>UniRef50_Q298C7 Cluster: GA18650-PA; n=1; Drosophila
pseudoobscura|Rep: GA18650-PA - Drosophila pseudoobscura
(Fruit fly)
Length = 381
Score = 50.4 bits (115), Expect = 4e-05
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL- 434
H IR L +KG + TQN+D L AG EK+IE HG+ + C+ C E D +
Sbjct: 148 HYFIRLLHEKGLLLRHYTQNIDTLDRLAGIPDEKLIEAHGSFHTNHCIGCKKEYDMAWMK 207
Query: 435 QEILTENNPDMESSFSMIRPD 497
+EI ++ P S +++PD
Sbjct: 208 KEIFSDRLPTCTSCKKIVKPD 228
>UniRef50_Q839C6 Cluster: NAD-dependent deacetylase; n=14;
Bacilli|Rep: NAD-dependent deacetylase - Enterococcus
faecalis (Streptococcus faecalis)
Length = 237
Score = 50.4 bits (115), Expect = 4e-05
Identities = 34/86 (39%), Positives = 47/86 (54%), Gaps = 3/86 (3%)
Frame = +3
Query: 159 YTVSRICEVSE-SKAKVLGKKLYRLAEIQLCATNVTHLCIRELE--KKGKVTSIVTQNVD 329
Y +SR C +E K K LY + Q N+ H + +LE K+GK IV+QN+D
Sbjct: 51 YLLSRTCLKTEPEKFYQFVKTLYH-PDAQ---PNIIHQKMAQLEQMKRGK---IVSQNID 103
Query: 330 XLHHKAGSEKVIELHGTSYLVQCLKC 407
LH KAGS++V++ HG Y C C
Sbjct: 104 GLHRKAGSQEVVDFHGNLYECYCQTC 129
>UniRef50_A1DG07 Cluster: SIR2 family histone deacetylase, putative;
n=3; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Neosartorya fischeri (strain
ATCC 1020 / DSM 3700 / NRRL 181)(Aspergillus
fischerianus (strain ATCC 1020 / DSM 3700 / NRRL 181))
Length = 425
Score = 42.7 bits (96), Expect(2) = 5e-05
Identities = 22/83 (26%), Positives = 38/83 (45%), Gaps = 3/83 (3%)
Frame = +3
Query: 258 VTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHE 431
+ H ++ L KG + TQN+D L AG EK++E HG+ C+ C +
Sbjct: 106 IAHSFVKLLHDKGLLLKHFTQNIDCLERLAGVPGEKIVEAHGSFASQHCIDCKAAYPEPQ 165
Query: 432 LQEILTENN-PDMESSFSMIRPD 497
++E + + P ++PD
Sbjct: 166 MKEAIAKGEVPHCPHCNGFVKPD 188
Score = 27.1 bits (57), Expect(2) = 5e-05
Identities = 10/16 (62%), Positives = 14/16 (87%)
Frame = +3
Query: 564 GPLKPDIVFFGDNVPQ 611
G +KPDIVFFG+ +P+
Sbjct: 183 GFVKPDIVFFGEALPE 198
>UniRef50_Q1QTH0 Cluster: Silent information regulator protein Sir2;
n=2; Oceanospirillales|Rep: Silent information regulator
protein Sir2 - Chromohalobacter salexigens (strain DSM
3043 / ATCC BAA-138 / NCIMB13768)
Length = 242
Score = 50.0 bits (114), Expect = 5e-05
Identities = 21/51 (41%), Positives = 30/51 (58%)
Frame = +3
Query: 225 RLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHG 377
R + + N H + ELE+ G S++TQN+D LH +AGS V+ LHG
Sbjct: 61 RREQTRQATPNAAHRALAELEQAGFQVSVITQNIDDLHERAGSRDVLHLHG 111
>UniRef50_Q6FKU1 Cluster: Similar to sp|P53686 Saccharomyces
cerevisiae YPL015c; n=3; Saccharomycetales|Rep: Similar
to sp|P53686 Saccharomyces cerevisiae YPL015c - Candida
glabrata (Yeast) (Torulopsis glabrata)
Length = 364
Score = 50.0 bits (114), Expect = 5e-05
Identities = 33/118 (27%), Positives = 57/118 (48%), Gaps = 2/118 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H ++ LEK G++ + TQN+D L +AG + ++E HG+ C+ C E + +
Sbjct: 89 HYLMKVLEKNGRLRRVYTQNIDTLEREAGIPDDYLVEAHGSFAKNHCIGCDKEFPLDDFK 148
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQ 611
+ L N + M + + D+ K E + +KP IVFFG+N+P+
Sbjct: 149 KALLRYN-----KYKM-KHNNDM-------KEFEYLRCPECEALIKPKIVFFGENLPK 193
>UniRef50_Q8N6T7-2 Cluster: Isoform 2 of Q8N6T7 ; n=5;
Catarrhini|Rep: Isoform 2 of Q8N6T7 - Homo sapiens
(Human)
Length = 328
Score = 49.6 bits (113), Expect = 7e-05
Identities = 21/51 (41%), Positives = 35/51 (68%), Gaps = 2/51 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKC 407
TH+ + +LE+ G + +V+QNVD LH ++G +K+ ELHG ++ +C KC
Sbjct: 94 THMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKC 144
>UniRef50_Q54GV7 Cluster: NAD(+)-dependent deacetylase, silent
information regulator protein (Sir2) family protein;
n=1; Dictyostelium discoideum AX4|Rep: NAD(+)-dependent
deacetylase, silent information regulator protein (Sir2)
family protein - Dictyostelium discoideum AX4
Length = 542
Score = 49.6 bits (113), Expect = 7e-05
Identities = 37/118 (31%), Positives = 58/118 (49%), Gaps = 2/118 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH I+ L++KGK+ TQN+D L H AG EK++ HG+ C+ C +D +
Sbjct: 372 THSFIKLLDEKGKLLRNYTQNIDTLEHVAGIDREKLVNCHGSFSTATCITCKLTVDGTTI 431
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
++ + + ME C+ + + QS +KPDIVFFG+N+P
Sbjct: 432 RDTIMK----MEIPL----------CQ-------QCNDGQSF---MKPDIVFFGENLP 465
>UniRef50_Q5KDE0 Cluster: NAD-dependent histone deacetylase,
putative; n=2; Filobasidiella neoformans|Rep:
NAD-dependent histone deacetylase, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 413
Score = 49.6 bits (113), Expect = 7e-05
Identities = 33/118 (27%), Positives = 52/118 (44%), Gaps = 2/118 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH ++ + + + TQN+D L AG ++E HG+ CLKC E+DR E+
Sbjct: 144 THYLLQLFNRHNLLKRVFTQNIDTLETLAGLPPHLIVEAHGSFATAHCLKCRREVDREEV 203
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
+ ++R D + G + G +KPDIVFFG+ +P
Sbjct: 204 LKAGVRKG-------EVVRCDATLKAMGK---------GKKCGGLVKPDIVFFGEGLP 245
>UniRef50_Q8N6T7 Cluster: Mono-ADP-ribosyltransferase sirtuin-6;
n=22; Euteleostomi|Rep: Mono-ADP-ribosyltransferase
sirtuin-6 - Homo sapiens (Human)
Length = 355
Score = 49.6 bits (113), Expect = 7e-05
Identities = 21/51 (41%), Positives = 35/51 (68%), Gaps = 2/51 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKC 407
TH+ + +LE+ G + +V+QNVD LH ++G +K+ ELHG ++ +C KC
Sbjct: 94 THMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKC 144
>UniRef50_Q8CJM9 Cluster: NAD-dependent deacetylase 2; n=3;
Actinomycetales|Rep: NAD-dependent deacetylase 2 -
Streptomyces coelicolor
Length = 241
Score = 49.6 bits (113), Expect = 7e-05
Identities = 23/53 (43%), Positives = 32/53 (60%), Gaps = 2/53 (3%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKC 407
N H + +LE++G ++TQNVD LH AG + KV+ELHGT+ C C
Sbjct: 71 NAAHRAVADLERRGVPVRVLTQNVDGLHQLAGVSARKVLELHGTARDCVCTGC 123
>UniRef50_Q89LY4 Cluster: NAD-dependent deacetylase 1; n=12;
Proteobacteria|Rep: NAD-dependent deacetylase 1 -
Bradyrhizobium japonicum
Length = 254
Score = 49.6 bits (113), Expect = 7e-05
Identities = 23/57 (40%), Positives = 35/57 (61%), Gaps = 4/57 (7%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKC--PYEID 422
H + L + GKV +++TQN+D LH +G E VIELHG + +C+ C Y++D
Sbjct: 90 HRALASLYRAGKVPAVITQNIDNLHQASGFAHEHVIELHGNTTYARCVGCGQTYQLD 146
Score = 33.1 bits (72), Expect = 6.7
Identities = 17/52 (32%), Positives = 27/52 (51%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGWPRFSCVQP 255
GIPD+RS G++ R+ +PI + FV + R W R + F+ +P
Sbjct: 38 GIPDFRSPG-GIWTRN--RPIPFDGFVASQEARDESWRRRFAMEETFAAARP 86
>UniRef50_UPI000051AA14 Cluster: PREDICTED: similar to NAD-dependent
deacetylase sirtuin-1 (hSIRT1) (hSIR2) (SIR2-like
protein 1); n=1; Apis mellifera|Rep: PREDICTED: similar
to NAD-dependent deacetylase sirtuin-1 (hSIRT1) (hSIR2)
(SIR2-like protein 1) - Apis mellifera
Length = 868
Score = 49.2 bits (112), Expect = 1e-04
Identities = 21/59 (35%), Positives = 34/59 (57%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQE 440
H I+ L+K+ K+ +QN+D L AG E VIE HG+ C +C Y++ +++E
Sbjct: 277 HRFIKMLDKQKKLLRNYSQNIDTLEQVAGIENVIECHGSFATASCTRCKYQVKADDIRE 335
>UniRef50_Q6C219 Cluster: Yarrowia lipolytica chromosome F of strain
CLIB122 of Yarrowia lipolytica; n=1; Yarrowia
lipolytica|Rep: Yarrowia lipolytica chromosome F of
strain CLIB122 of Yarrowia lipolytica - Yarrowia
lipolytica (Candida lipolytica)
Length = 320
Score = 49.2 bits (112), Expect = 1e-04
Identities = 35/118 (29%), Positives = 55/118 (46%), Gaps = 2/118 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAGSE--KVIELHGTSYLVQCLKCPYEIDRHEL 434
TH ++ L+ KGK+ I TQN+D L H AG E K+++ HG ++ C +C ++ L
Sbjct: 134 THAFLKLLQDKGKLLRIYTQNIDDLEHIAGIEESKMVQCHGAFHMATCRQCGAKVTCESL 193
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
+ + M CR + +G +KPDIVFFG+ +P
Sbjct: 194 RPEIVAGEIPM--------------CRRKR-----------CEGVIKPDIVFFGEALP 226
>UniRef50_Q9I4L0 Cluster: NAD-dependent deacetylase 1; n=10;
Bacteria|Rep: NAD-dependent deacetylase 1 - Pseudomonas
aeruginosa
Length = 250
Score = 49.2 bits (112), Expect = 1e-04
Identities = 26/74 (35%), Positives = 38/74 (51%)
Frame = +3
Query: 186 SESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVI 365
++ A V G +R ++ N H I L + T +VTQNVD LH +AGS V+
Sbjct: 54 ADDPALVWGWYEWRRLKVLGVQPNPAHRAIAALSGRIANTRLVTQNVDDLHERAGSRDVL 113
Query: 366 ELHGTSYLVQCLKC 407
LHG+ + +C C
Sbjct: 114 HLHGSLHAPRCATC 127
>UniRef50_Q9VH08 Cluster: CG6284-PA; n=9; Eumetazoa|Rep: CG6284-PA -
Drosophila melanogaster (Fruit fly)
Length = 317
Score = 48.8 bits (111), Expect = 1e-04
Identities = 22/51 (43%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAGSEK--VIELHGTSYLVQCLKC 407
TH+ I L + G V +++QN+D LH K+G ++ + ELHG Y+ QC KC
Sbjct: 94 THMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKC 144
>UniRef50_Q8Y015 Cluster: NAD-dependent deacetylase; n=11;
Bacteria|Rep: NAD-dependent deacetylase - Ralstonia
solanacearum (Pseudomonas solanacearum)
Length = 246
Score = 48.8 bits (111), Expect = 1e-04
Identities = 29/65 (44%), Positives = 35/65 (53%), Gaps = 4/65 (6%)
Frame = +3
Query: 225 RLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHG----TSYLV 392
R A + N HL I L + K ++VTQNVD LH +AGS VIELHG +L
Sbjct: 77 RRARVSQVQPNPAHLAIAALATR-KTVALVTQNVDGLHQRAGSVGVIELHGNLFANKWLD 135
Query: 393 QCLKC 407
C KC
Sbjct: 136 GCGKC 140
>UniRef50_Q4APN6 Cluster: Silent information regulator protein Sir2;
n=1; Chlorobium phaeobacteroides BS1|Rep: Silent
information regulator protein Sir2 - Chlorobium
phaeobacteroides BS1
Length = 217
Score = 48.4 bits (110), Expect = 2e-04
Identities = 25/71 (35%), Positives = 38/71 (53%)
Frame = +3
Query: 201 KVLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGT 380
KVLG R + C + H + L +VTQN+D +H +AGS+ VIELHG+
Sbjct: 44 KVLGFHEKRRKSVLDCQPHEGHSVVAVLPN----AKVVTQNIDGMHQRAGSKDVIELHGS 99
Query: 381 SYLVQCLKCPY 413
+ ++C C +
Sbjct: 100 LWRLRCQSCGF 110
>UniRef50_A7SX90 Cluster: Predicted protein; n=3; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 306
Score = 48.4 bits (110), Expect = 2e-04
Identities = 32/118 (27%), Positives = 57/118 (48%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
++ H I +LE+ G + +QN+D L AG +VI+ HG+ C++C +++ +
Sbjct: 140 SLCHRFIHQLEEHGHLLRNYSQNIDTLEQVAGITRVIQCHGSFSTASCMRCKHKVPCEAI 199
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
+E + N + S+ S PD + +KPDIVFFG+++P
Sbjct: 200 KEDIFRKNIPVCSTCS---PD------------------EEFPSIMKPDIVFFGESLP 236
>UniRef50_Q0CR31 Cluster: NAD-dependent histone deacetylase SIR2;
n=2; Pezizomycotina|Rep: NAD-dependent histone
deacetylase SIR2 - Aspergillus terreus (strain NIH 2624)
Length = 1068
Score = 48.4 bits (110), Expect = 2e-04
Identities = 22/55 (40%), Positives = 34/55 (61%), Gaps = 2/55 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEI 419
TH IR L+ KGK+ + TQN+D + AG EK+++ HG+ C+KC Y++
Sbjct: 248 THGFIRLLQDKGKLLTNYTQNIDNIEANAGVVPEKIVQCHGSFATATCVKCHYKV 302
Score = 34.3 bits (75), Expect = 2.9
Identities = 13/20 (65%), Positives = 17/20 (85%)
Frame = +1
Query: 94 SLGIPDYRSEDVGLYARSNH 153
SLGIPD+RS+D GLY++ H
Sbjct: 190 SLGIPDFRSKDTGLYSQLEH 209
>UniRef50_A7EMW8 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 533
Score = 48.4 bits (110), Expect = 2e-04
Identities = 37/134 (27%), Positives = 60/134 (44%), Gaps = 18/134 (13%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH I+ L+ KGK+ + TQN+D + AG E VI+ HG+ C +C ++ E+
Sbjct: 278 THQFIKVLQDKGKLLTNYTQNIDGIESAAGILPENVIQCHGSFATATCQQCSTQVKGTEV 337
Query: 435 -QEILTEN-------------NPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGP- 569
EI N P + + R + + KN + + + P
Sbjct: 338 FPEIKAGNIPRCKVKGCKIPAPPPPKQTLKRKRSSNGGSKKRGRSKNDDENEEDDIPQPG 397
Query: 570 -LKPDIVFFGDNVP 608
+KPDI FFG+++P
Sbjct: 398 IMKPDITFFGESLP 411
>UniRef50_Q8A3H9 Cluster: NAD-dependent deacetylase; n=3;
Bacteroides|Rep: NAD-dependent deacetylase - Bacteroides
thetaiotaomicron
Length = 234
Score = 48.4 bits (110), Expect = 2e-04
Identities = 27/66 (40%), Positives = 38/66 (57%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
N H + ELEK VT ++TQNVD LH +AGS ++ LHG V + PY + H +
Sbjct: 66 NRGHELLAELEKNFNVT-VITQNVDNLHERAGSSHIVHLHGELTKVCSSRDPY--NPHYI 122
Query: 435 QEILTE 452
+E+ E
Sbjct: 123 KELKPE 128
>UniRef50_A7H7B6 Cluster: Silent information regulator protein Sir2;
n=2; Anaeromyxobacter|Rep: Silent information regulator
protein Sir2 - Anaeromyxobacter sp. Fw109-5
Length = 270
Score = 47.6 bits (108), Expect = 3e-04
Identities = 23/61 (37%), Positives = 37/61 (60%), Gaps = 1/61 (1%)
Frame = +3
Query: 219 LYRLAEIQLCATNVTHLCIRELEKK-GKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQ 395
L+R + N H + LE+ G+ ++VTQN+D LH +AGSE+V+ +HG + V+
Sbjct: 73 LHRFGVCRDARPNAGHAALVALERALGERFTLVTQNIDGLHRRAGSERVLCIHGDAAYVR 132
Query: 396 C 398
C
Sbjct: 133 C 133
>UniRef50_Q6BPH5 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Saccharomycetaceae|Rep: Debaryomyces hansenii chromosome
E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 573
Score = 47.6 bits (108), Expect = 3e-04
Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 2/117 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H I+ L+ KGK+ TQN+D L G EK+I+ HG+ C+ C Y++ ++
Sbjct: 332 HAFIKLLQNKGKLLRNYTQNIDNLESNVGIKPEKLIQCHGSFATASCVTCKYQVKGEKIY 391
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
+ E R NK + + +S G +KPDI FFG+ +P
Sbjct: 392 PKIREKEVPYCPKCKNAR-----KILLNK---EDAYVPESY-GVMKPDITFFGEPLP 439
>UniRef50_Q96EB6 Cluster: NAD-dependent deacetylase sirtuin-1; n=29;
Euteleostomi|Rep: NAD-dependent deacetylase sirtuin-1 -
Homo sapiens (Human)
Length = 747
Score = 47.6 bits (108), Expect = 3e-04
Identities = 20/56 (35%), Positives = 33/56 (58%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEID 422
++ H I +K+GK+ TQN+D L AG +++I+ HG+ CL C Y++D
Sbjct: 324 SLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVD 379
>UniRef50_Q9CBW6 Cluster: NAD-dependent deacetylase; n=14;
Mycobacterium|Rep: NAD-dependent deacetylase -
Mycobacterium leprae
Length = 237
Score = 47.6 bits (108), Expect = 3e-04
Identities = 32/100 (32%), Positives = 51/100 (51%), Gaps = 2/100 (2%)
Frame = +3
Query: 201 KVLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGT 380
+V G L+R + N H I +++ +V S++TQNVD LH +AGS V LHG+
Sbjct: 48 RVWGWYLWRHYLVANVKPNDGHRAIAAWQEQIEV-SVITQNVDDLHERAGSTPVHHLHGS 106
Query: 381 SYLVQCLKC--PYEIDRHELQEILTENNPDMESSFSMIRP 494
+ C +C Y ++ E + E +P + +IRP
Sbjct: 107 LFKFHCARCNVAYTGALPDMPEPVLEVDPPVCYCGGLIRP 146
>UniRef50_Q011Q8 Cluster: NAD-dependent deacetylase SIRT2; n=2;
Ostreococcus|Rep: NAD-dependent deacetylase SIRT2 -
Ostreococcus tauri
Length = 394
Score = 37.9 bits (84), Expect(2) = 3e-04
Identities = 27/86 (31%), Positives = 38/86 (44%), Gaps = 3/86 (3%)
Frame = +3
Query: 249 ATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEID 422
A TH I+ L KG + TQN+D L G EKV+ HG CL+ +E D
Sbjct: 170 APTPTHYFIKLLHDKGILRRCFTQNIDSLERATGLPKEKVVPAHGNFDGAHCLR-GHEAD 228
Query: 423 RHELQEILTENNPDMESSF-SMIRPD 497
E+ + P + S ++PD
Sbjct: 229 VDEVADACRAGTPMICSKCGEYVKPD 254
Score = 29.1 bits (62), Expect(2) = 3e-04
Identities = 10/14 (71%), Positives = 14/14 (100%)
Frame = +3
Query: 570 LKPDIVFFGDNVPQ 611
+KPDIVFFG+N+P+
Sbjct: 251 VKPDIVFFGENLPR 264
>UniRef50_Q7S6G9 Cluster: Putative uncharacterized protein
NCU04737.1; n=3; Sordariomycetes|Rep: Putative
uncharacterized protein NCU04737.1 - Neurospora crassa
Length = 670
Score = 47.2 bits (107), Expect = 4e-04
Identities = 21/55 (38%), Positives = 35/55 (63%), Gaps = 2/55 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEI 419
TH I L++KGK+ + +QN+D L KAG +K+++ HG+ C+KC Y++
Sbjct: 278 THAFIALLQQKGKLLTNYSQNIDNLEAKAGIHPDKLVQCHGSFATATCVKCGYKV 332
>UniRef50_UPI00004997CB Cluster: Sir2 family transcriptional
regulator; n=2; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 346
Score = 46.8 bits (106), Expect = 5e-04
Identities = 40/119 (33%), Positives = 55/119 (46%), Gaps = 2/119 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH + L K G ++ + TQN+D L ++G +EK++ HG Y CLKC
Sbjct: 176 THYFLTYLNKLGYISMLFTQNIDGLEIQSGFPNEKLVMAHGNYYSGHCLKCKKSFK---- 231
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQ 611
Q +N +R DG V C S KG +KPDIVFFG+ +PQ
Sbjct: 232 QSYFIDN----------VR-DGKV-C-----------YCDSCKGLVKPDIVFFGEGLPQ 267
>UniRef50_A3LN35 Cluster: NAD-dependent histone deacetylase SIR2;
n=1; Pichia stipitis|Rep: NAD-dependent histone
deacetylase SIR2 - Pichia stipitis (Yeast)
Length = 391
Score = 46.8 bits (106), Expect = 5e-04
Identities = 33/122 (27%), Positives = 58/122 (47%), Gaps = 3/122 (2%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRH 428
++ H I+ L+ KGK+ TQN+D L + G +K+I+ HG+ CL C H
Sbjct: 179 SMLHSFIKLLQDKGKLLRNYTQNIDNLESRVGIHPDKLIQCHGSFGSASCLTCSNRFAGH 238
Query: 429 EL-QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNV 605
++ + I ++ P + + I+ A + G +KPDI FFG+++
Sbjct: 239 KIFEHIRHQHVPRCSTCWKTIQ------------------EAVIIHGVIKPDITFFGEDL 280
Query: 606 PQ 611
P+
Sbjct: 281 PK 282
>UniRef50_Q046W9 Cluster: NAD-dependent protein deacetylase, SIR2
family; n=6; Lactobacillus|Rep: NAD-dependent protein
deacetylase, SIR2 family - Lactobacillus gasseri (strain
ATCC 33323 / DSM 20243)
Length = 237
Score = 46.4 bits (105), Expect = 7e-04
Identities = 20/45 (44%), Positives = 29/45 (64%)
Frame = +3
Query: 306 SIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQE 440
+++TQNVD L KAG++ VIE HG Y + C KC +I E ++
Sbjct: 98 TLITQNVDGLDKKAGNKHVIEFHGNLYNIFCTKCHEKISYEEYKK 142
>UniRef50_A1ZZG3 Cluster: NAD-dependent deacetylase; n=35;
Bacteria|Rep: NAD-dependent deacetylase - Microscilla
marina ATCC 23134
Length = 245
Score = 46.4 bits (105), Expect = 7e-04
Identities = 22/41 (53%), Positives = 27/41 (65%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHG 377
N HL + LE K +V I+TQN+D LH KAGS V+ LHG
Sbjct: 81 NEGHLALARLEAKYEVV-IITQNIDDLHEKAGSSNVLHLHG 120
>UniRef50_Q0LIC7 Cluster: Silent information regulator protein Sir2;
n=2; Bacteria|Rep: Silent information regulator protein
Sir2 - Herpetosiphon aurantiacus ATCC 23779
Length = 244
Score = 40.3 bits (90), Expect(2) = 7e-04
Identities = 24/92 (26%), Positives = 42/92 (45%), Gaps = 3/92 (3%)
Frame = +3
Query: 231 AEIQLCATNVTHLCIRELEK---KGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCL 401
+++Q N H + E+ K + +++TQN+D LH AGS ++E HG+ +C
Sbjct: 67 SQLQTTQPNAAHRALARFEQSLGKHQRFTLITQNIDGLHQLAGSRNLVEFHGSLRQSRCS 126
Query: 402 KCPYEIDRHELQEILTENNPDMESSFSMIRPD 497
+ Q T+ P + +RPD
Sbjct: 127 DEQCDQPSFVDQRAHTQTLPLCPTCGKPLRPD 158
Score = 25.4 bits (53), Expect(2) = 7e-04
Identities = 12/25 (48%), Positives = 16/25 (64%)
Frame = +3
Query: 567 PLKPDIVFFGDNVPQYRVGTSQKRS 641
PL+PDIV F + +P + T KRS
Sbjct: 154 PLRPDIVLFEEAIPVW-AETQAKRS 177
>UniRef50_Q1RL71 Cluster: Zinc finger protein; n=2; Ciona
intestinalis|Rep: Zinc finger protein - Ciona
intestinalis (Transparent sea squirt)
Length = 523
Score = 46.0 bits (104), Expect = 9e-04
Identities = 25/69 (36%), Positives = 36/69 (52%), Gaps = 2/69 (2%)
Frame = +3
Query: 207 LGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGT 380
L K+LY + + N+ H +R L +KG + + TQN+D L AG K++E HGT
Sbjct: 177 LAKELYPSGKYR---PNIVHYFVRCLHEKGLLLRMYTQNIDGLERLAGIPPSKLVEAHGT 233
Query: 381 SYLVQCLKC 407
C KC
Sbjct: 234 FSTASCTKC 242
>UniRef50_A6XDL2 Cluster: Sirtuin 1; n=2; Schistosoma|Rep: Sirtuin 1
- Schistosoma mansoni (Blood fluke)
Length = 568
Score = 46.0 bits (104), Expect = 9e-04
Identities = 23/70 (32%), Positives = 37/70 (52%), Gaps = 1/70 (1%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHEL 434
++TH I LE K K+ TQN+D L AG ++I+ HG+ C C ++ +
Sbjct: 225 SITHRMIALLESKDKLLRNYTQNIDTLEQAAGITRLIQCHGSFASATCTNCKLKVSSDFI 284
Query: 435 QE-ILTENNP 461
+E I T++ P
Sbjct: 285 KEAIFTQSIP 294
>UniRef50_Q6CAJ8 Cluster: Similar to sp|P53687 Saccharomyces
cerevisiae HST3 protein; n=1; Yarrowia lipolytica|Rep:
Similar to sp|P53687 Saccharomyces cerevisiae HST3
protein - Yarrowia lipolytica (Candida lipolytica)
Length = 385
Score = 46.0 bits (104), Expect = 9e-04
Identities = 22/70 (31%), Positives = 40/70 (57%), Gaps = 3/70 (4%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHK--AGSEKVIELHGTSYLVQCLKCPYEID-RHEL 434
H + +L+ GK+ S TQN+D L HK ++K+++LHG + C++C ++ + +
Sbjct: 111 HEFVAKLDTAGKLLSCYTQNIDSLEHKTEVSAKKIVQLHGHLDTLNCIQCSEKLQWKDRV 170
Query: 435 QEILTENNPD 464
+E E N D
Sbjct: 171 KEKKKEENND 180
>UniRef50_Q4P3S4 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 400
Score = 46.0 bits (104), Expect = 9e-04
Identities = 25/73 (34%), Positives = 37/73 (50%), Gaps = 8/73 (10%)
Frame = +3
Query: 237 IQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKA------GSEKVIELHGTSYLVQC 398
+++ N H I +++ G V +TQNVD LHH A + ++ELHGT V C
Sbjct: 102 VRVAQANKGHYSIAAIQRLGYVPEYITQNVDNLHHAATPSASLAASTILELHGTLKHVVC 161
Query: 399 LKCP--YEIDRHE 431
+ P Y D H+
Sbjct: 162 VSSPEGYRKDEHK 174
Score = 38.3 bits (85), Expect = 0.18
Identities = 22/63 (34%), Positives = 33/63 (52%), Gaps = 5/63 (7%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFV----KYPKVRQRYWARNYIGWPRFSCVQPT-SH 264
GI YR E+ +++PI Y EFV K RQRY++R+++G+P Q H
Sbjct: 52 GIAPYRGENGHYTIHKHYRPIFYHEFVDASDKGHLARQRYFSRSFLGFPTVRVAQANKGH 111
Query: 265 ISV 273
S+
Sbjct: 112 YSI 114
Score = 32.7 bits (71), Expect = 8.9
Identities = 14/39 (35%), Positives = 21/39 (53%)
Frame = +3
Query: 492 PDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
PDGDV+ + + G LKP ++FFG++VP
Sbjct: 252 PDGDVELHNVDYSTFNYPACPNCGGVLKPAVIFFGESVP 290
>UniRef50_A4QUX8 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 460
Score = 46.0 bits (104), Expect = 9e-04
Identities = 34/101 (33%), Positives = 49/101 (48%), Gaps = 3/101 (2%)
Frame = +3
Query: 204 VLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHG 377
VL K+LY + Q ++H I L KKG + TQN+D L +AG EKVIE HG
Sbjct: 96 VLAKELYP-GKFQ---PTISHAFIALLSKKGLLQMNFTQNIDCLERQAGVPGEKVIEAHG 151
Query: 378 TSYLVQCLKCPYEI-DRHELQEILTENNPDMESSFSMIRPD 497
+ C++C D L + E P S +++P+
Sbjct: 152 SFATQSCIECKELFPDDEMLLHVEKEIVPRCASCNGLVKPN 192
>UniRef50_Q3E2I1 Cluster: Silent information regulator protein Sir2;
n=7; Bacteria|Rep: Silent information regulator protein
Sir2 - Chloroflexus aurantiacus J-10-fl
Length = 254
Score = 45.6 bits (103), Expect = 0.001
Identities = 22/61 (36%), Positives = 33/61 (54%), Gaps = 2/61 (3%)
Frame = +3
Query: 222 YRLAEIQLCAT--NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQ 395
Y ++ C N H + +L ++VTQN+D LH +AGS +VIELHG + +
Sbjct: 71 YAERRVKACTAQPNPAHHALADLATLVPRLTLVTQNIDGLHQRAGSPQVIELHGNIHRAR 130
Query: 396 C 398
C
Sbjct: 131 C 131
>UniRef50_Q1D737 Cluster: NAD-dependent deacetylase; n=1; Myxococcus
xanthus DK 1622|Rep: NAD-dependent deacetylase -
Myxococcus xanthus (strain DK 1622)
Length = 245
Score = 45.6 bits (103), Expect = 0.001
Identities = 16/33 (48%), Positives = 25/33 (75%)
Frame = +3
Query: 309 IVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKC 407
+ TQNVD LH +AGS++V+E+HG + +C +C
Sbjct: 93 LATQNVDGLHTRAGSQRVVEMHGNLFKTRCSRC 125
>UniRef50_Q6C8V5 Cluster: Similar to tr|Q9FY91 Arabidopsis thaliana
SIR2-family protein; n=1; Yarrowia lipolytica|Rep:
Similar to tr|Q9FY91 Arabidopsis thaliana SIR2-family
protein - Yarrowia lipolytica (Candida lipolytica)
Length = 411
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/44 (43%), Positives = 25/44 (56%)
Frame = +1
Query: 100 GIPDYRSEDVGLYARSNHKPIQYQEFVKYPKVRQRYWARNYIGW 231
G+PDYR NH+P Y EFV R+RYW+R +IG+
Sbjct: 63 GLPDYRGPTGTYTTNPNHQPTLYHEFVSDEHKRKRYWSRAWIGY 106
Score = 40.3 bits (90), Expect = 0.044
Identities = 26/89 (29%), Positives = 43/89 (48%), Gaps = 21/89 (23%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHH-------------------KAGSE--KVIEL 371
NV H + + G ++ ++TQNVD LH +AG E ++EL
Sbjct: 116 NVAHEVLTGWLRGGHISGLITQNVDGLHKLSQVSGGDIVDNVNVSADLRAGREVPALVEL 175
Query: 372 HGTSYLVQCLKCPYEIDRHELQEILTENN 458
HG++Y V CL C + R + Q+ + ++N
Sbjct: 176 HGSAYRVHCLSCGDQTSREDFQDRMAKDN 204
>UniRef50_A6RRE3 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 526
Score = 45.6 bits (103), Expect = 0.001
Identities = 39/132 (29%), Positives = 54/132 (40%), Gaps = 16/132 (12%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPY------- 413
TH I L+ GK+ + TQN+D + AG +K+I HG+ C C +
Sbjct: 274 THQFIALLQAHGKLLTNYTQNIDNIESMAGISPDKIIHCHGSFATATCQVCGHKVKGDAI 333
Query: 414 --EIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSV-----KGPL 572
+I + EN P S S R G K KN + G +
Sbjct: 334 FDDIKNGHIPRCKMENCPPGSQS-SNPRKRKKSSMGGKKKKNGQYSDDDESDDIPESGIM 392
Query: 573 KPDIVFFGDNVP 608
KPDI FFG+N+P
Sbjct: 393 KPDITFFGENLP 404
>UniRef50_A4VDQ9 Cluster: Chromatin regulatory protein sir2; n=1;
Tetrahymena thermophila SB210|Rep: Chromatin regulatory
protein sir2 - Tetrahymena thermophila SB210
Length = 279
Score = 45.2 bits (102), Expect = 0.002
Identities = 35/120 (29%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAGSEK--VIELHGTSYLVQCLKCPYEIDRHEL 434
+H I EL K+ + +TQN+D L KAG +K +I+ HG C++C E
Sbjct: 103 SHKFITELAKQNLLYLNITQNIDGLELKAGLDKKYLIQAHGNLEKSHCIECHKEDTIEYF 162
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQY 614
+E +++ D V+CR K + +G LKP + FFG+ +P Y
Sbjct: 163 KE-------------GVLKSDDAVNCRKTK----------NCQGKLKPSVTFFGEKLPFY 199
>UniRef50_A5DJ74 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 522
Score = 45.2 bits (102), Expect = 0.002
Identities = 33/117 (28%), Positives = 54/117 (46%), Gaps = 2/117 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H I+ L+ KG + TQN+D L G S++V++ HG+ C+ C I HE+
Sbjct: 281 HAFIKTLDDKGILLRNYTQNIDNLESNVGINSDRVVQCHGSFATATCVTCKNTIPGHEIF 340
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
E + N ++ + R + + +S G +KPDI FFG+ +P
Sbjct: 341 ECI--RNKEVAYCTKC------TNSRLALMDKDDAYVPESY-GVMKPDITFFGELLP 388
>UniRef50_Q607X6 Cluster: NAD-dependent deacetylase; n=1;
Methylococcus capsulatus|Rep: NAD-dependent deacetylase
- Methylococcus capsulatus
Length = 255
Score = 45.2 bits (102), Expect = 0.002
Identities = 26/76 (34%), Positives = 36/76 (47%), Gaps = 2/76 (2%)
Frame = +3
Query: 198 AKVLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHG 377
A V G +R + N H I L +++TQNVD LH +AGS I LHG
Sbjct: 61 ALVWGWYEWRRTRVLRAEPNPAHYAIAALAADCPRLTLITQNVDDLHERAGSADPIRLHG 120
Query: 378 TSYLVQCLKC--PYEI 419
+ + +C C PY +
Sbjct: 121 SLHHPRCSACEAPYRL 136
>UniRef50_Q0LN22 Cluster: Silent information regulator protein Sir2;
n=1; Herpetosiphon aurantiacus ATCC 23779|Rep: Silent
information regulator protein Sir2 - Herpetosiphon
aurantiacus ATCC 23779
Length = 243
Score = 44.8 bits (101), Expect = 0.002
Identities = 18/42 (42%), Positives = 27/42 (64%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGT 380
N H + +LE+ G + TQN+D LH +AGS +V E+HG+
Sbjct: 82 NAGHYALAQLEQLGTQFKLFTQNIDSLHQRAGSSQVYEVHGS 123
>UniRef50_Q22KA8 Cluster: Transcriptional regulator, Sir2 family
protein; n=3; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 386
Score = 44.8 bits (101), Expect = 0.002
Identities = 18/51 (35%), Positives = 34/51 (66%), Gaps = 2/51 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKC 407
+H+ + +L ++G + +++QN+D LH ++G + ELHG + L +CLKC
Sbjct: 96 SHMALVKLNQEGILKYLISQNIDGLHRRSGFNPNSLSELHGNTNLEKCLKC 146
>UniRef50_Q175I4 Cluster: Chromatin regulatory protein sir2; n=3;
Coelomata|Rep: Chromatin regulatory protein sir2 - Aedes
aegypti (Yellowfever mosquito)
Length = 720
Score = 44.8 bits (101), Expect = 0.002
Identities = 19/65 (29%), Positives = 36/65 (55%), Gaps = 2/65 (3%)
Frame = +3
Query: 234 EIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEK--VIELHGTSYLVQCLKC 407
++ L TH+ + EL ++G + +V+QN D LH ++G + + E+HG Y+ C C
Sbjct: 120 DLSLADPTYTHMALSELHRRGILKHVVSQNCDGLHLRSGLPRFCLSEVHGNMYVEVCKNC 179
Query: 408 PYEID 422
++
Sbjct: 180 KPNVE 184
>UniRef50_A2F9H1 Cluster: Transcriptional regulator, Sir2 family
protein; n=2; Trichomonas vaginalis|Rep: Transcriptional
regulator, Sir2 family protein - Trichomonas vaginalis
G3
Length = 304
Score = 44.8 bits (101), Expect = 0.002
Identities = 36/111 (32%), Positives = 51/111 (45%), Gaps = 2/111 (1%)
Frame = +3
Query: 282 LEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQEILTEN 455
+ KKG + TQN+D L AG +K++E HGT C +C E E+++ L
Sbjct: 103 MAKKGILLKQYTQNIDGLERIAGVPEDKLVESHGTFSTAHCTECKKEWKLEEIRDKLLLG 162
Query: 456 NPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
P + + D DC KG +KPDIVFFG+N+P
Sbjct: 163 KP-LHCT--------DPDC----------------KGFIKPDIVFFGENLP 188
>UniRef50_Q6MJJ2 Cluster: NAD-dependent deacetylase; n=5;
Proteobacteria|Rep: NAD-dependent deacetylase -
Bdellovibrio bacteriovorus
Length = 235
Score = 44.8 bits (101), Expect = 0.002
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 5/72 (6%)
Frame = +3
Query: 207 LGKKLYRLAEIQL----CATNVTHLCIRELEKKGKVTSI-VTQNVDXLHHKAGSEKVIEL 371
L ++ Y L QL A N H + +LE + + VTQNVD LH +AGS+ ++ +
Sbjct: 53 LVQRFYNLRRAQLRDPNLAPNPAHQALVDLENLWEGNFLLVTQNVDNLHRRAGSKNLLHM 112
Query: 372 HGTSYLVQCLKC 407
HG V CL C
Sbjct: 113 HGRLDRVFCLHC 124
>UniRef50_Q7SCL4 Cluster: Putative uncharacterized protein NCU00523.1;
n=2; Pezizomycotina|Rep: Putative uncharacterized protein
NCU00523.1 - Neurospora crassa
Length = 1220
Score = 44.4 bits (100), Expect = 0.003
Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 4/84 (4%)
Frame = +3
Query: 258 VTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKC--PYEIDR 425
++H+ I L KG + + TQN+D L AG ++ ++E HG+ +C+ C PY D+
Sbjct: 948 ISHVFISLLATKGLLYQLFTQNIDCLERAAGVPADLIVEAHGSFASQRCIDCKTPYPDDK 1007
Query: 426 HELQEILTENNPDMESSFSMIRPD 497
+ + P E +++PD
Sbjct: 1008 MR-EHVSRAEVPHCEKCNGLVKPD 1030
>UniRef50_Q5KA61 Cluster: Histone deacetylase, putative; n=1;
Filobasidiella neoformans|Rep: Histone deacetylase,
putative - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 596
Score = 44.4 bits (100), Expect = 0.003
Identities = 21/67 (31%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQE- 440
H I+ LE +G + TQN+D L AG E+V++ HG+ CL+C + ++
Sbjct: 231 HRWIKMLEDRGVLLRNYTQNIDTLESLAGVERVLQCHGSFKTASCLRCKQRVPGRTIEPY 290
Query: 441 ILTENNP 461
I+++ P
Sbjct: 291 IMSQQIP 297
>UniRef50_A5DSX8 Cluster: NAD-dependent histone deacetylase SIR2;
n=1; Lodderomyces elongisporus NRRL YB-4239|Rep:
NAD-dependent histone deacetylase SIR2 - Lodderomyces
elongisporus (Yeast) (Saccharomyces elongisporus)
Length = 568
Score = 44.4 bits (100), Expect = 0.003
Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 2/117 (1%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H I L++KGK+ TQN+D L AG EK+++ HG+ C+ C + +
Sbjct: 328 HSFIYLLQQKGKLLRNYTQNIDNLESYAGIVPEKMVQCHGSFATATCVTCRNTVAGETIF 387
Query: 438 EILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
+ + + E + P + + KN + + +S G KPDI FFG+ +P
Sbjct: 388 KTIRQK----EIPYC---PRCEAKKKSILKKNDDYYFPESY-GVYKPDITFFGEALP 436
>UniRef50_Q9I4E1 Cluster: NAD-dependent deacetylase 2; n=6;
Pseudomonadaceae|Rep: NAD-dependent deacetylase 2 -
Pseudomonas aeruginosa
Length = 256
Score = 44.4 bits (100), Expect = 0.003
Identities = 27/71 (38%), Positives = 37/71 (52%), Gaps = 3/71 (4%)
Frame = +3
Query: 213 KKLYRLAEIQLCAT-NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGS--EKVIELHGTS 383
K L L + L A N H I EL+K ++TQN+D H +AGS E++IE+HG
Sbjct: 72 KYLAELGKACLAARPNAGHEAIAELQKHKPECWVLTQNIDGFHRQAGSPAERLIEIHGEL 131
Query: 384 YLVQCLKCPYE 416
+ C C E
Sbjct: 132 APLYCQSCGAE 142
>UniRef50_A5USR3 Cluster: Silent information regulator protein Sir2;
n=3; Chloroflexi (class)|Rep: Silent information
regulator protein Sir2 - Roseiflexus sp. RS-1
Length = 259
Score = 44.0 bits (99), Expect = 0.004
Identities = 20/61 (32%), Positives = 35/61 (57%)
Frame = +3
Query: 222 YRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCL 401
YR + VTH + +LE+ +++TQ++D LH +AGS +IEL+G+ +C
Sbjct: 71 YRRMLAERAQPGVTHYALVDLEQHYPAFTLITQSIDGLHWRAGSRDLIELNGSLRRCRCF 130
Query: 402 K 404
+
Sbjct: 131 E 131
>UniRef50_P06700 Cluster: NAD-dependent histone deacetylase SIR2;
n=13; Saccharomycetales|Rep: NAD-dependent histone
deacetylase SIR2 - Saccharomyces cerevisiae (Baker's
yeast)
Length = 562
Score = 44.0 bits (99), Expect = 0.004
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 10/125 (8%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL- 434
H I+ L+ KGK+ TQN+D L AG ++K+++ HG+ C+ C + + +
Sbjct: 326 HSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIF 385
Query: 435 QEILTENNPDMESSFSMIR---PDG---DVDCRGNK*KNSELHS-AQSVKGPLKPDIVFF 593
+I P + R P+G V ++ SE + G LKPDI FF
Sbjct: 386 NKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFF 445
Query: 594 GDNVP 608
G+ +P
Sbjct: 446 GEALP 450
>UniRef50_Q5AQ47 Cluster: Potential Sir2 family histone deacetylase;
n=2; Candida albicans|Rep: Potential Sir2 family histone
deacetylase - Candida albicans (Yeast)
Length = 657
Score = 43.2 bits (97), Expect = 0.006
Identities = 39/146 (26%), Positives = 65/146 (44%), Gaps = 23/146 (15%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL- 434
H I+ L+ K K+ TQN+D L AG E +I+ HG+ C+ C Y++D +
Sbjct: 373 HSFIKLLQDKNKLLRNYTQNIDNLESYAGIHKENLIQCHGSFATASCITCGYKVDGEIIF 432
Query: 435 QEILTENNPDM----ESSFSMIRPDGDVDCRGNK*K---------------NSELHSAQS 557
EI + P E S+++ + K K E + +S
Sbjct: 433 PEIKNKEIPYCPKCNEVKQSILKKGKKTKSKSKKKKKKKNKPYDDDDEEEEEGETYFHES 492
Query: 558 VKGPLKPDIVFFGDNVPQ-YRVGTSQ 632
G +KPDI FFG+ +P+ +++ +Q
Sbjct: 493 F-GVMKPDITFFGEQLPENFKIAINQ 517
>UniRef50_Q9NRC8 Cluster: NAD-dependent deacetylase sirtuin-7; n=24;
Eumetazoa|Rep: NAD-dependent deacetylase sirtuin-7 -
Homo sapiens (Human)
Length = 400
Score = 43.2 bits (97), Expect = 0.006
Identities = 20/61 (32%), Positives = 33/61 (54%), Gaps = 2/61 (3%)
Frame = +3
Query: 231 AEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEK--VIELHGTSYLVQCLK 404
A++ +TH+ I L ++ V +V+QN D LH ++G + + ELHG Y+ C
Sbjct: 138 ADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTS 197
Query: 405 C 407
C
Sbjct: 198 C 198
>UniRef50_Q3V7G9 Cluster: Putative cobalamin biosynthetic protein;
n=2; Acinetobacter|Rep: Putative cobalamin biosynthetic
protein - Acinetobacter sp. (strain ADP1)
Length = 233
Score = 42.7 bits (96), Expect = 0.008
Identities = 22/57 (38%), Positives = 31/57 (54%)
Frame = +3
Query: 225 RLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQ 395
R I N+ H I +LE +V ++TQN+D LH +AGS V+ LHG L +
Sbjct: 56 RRKNILAAQPNLAHQIIAQLESCYQV-QVITQNIDDLHERAGSTHVLHLHGNIRLAK 111
>UniRef50_Q875P9 Cluster: HST1; n=1; Lachancea kluyveri|Rep: HST1 -
Saccharomyces kluyveri (Yeast) (Saccharomyces
silvestris)
Length = 414
Score = 42.7 bits (96), Expect = 0.008
Identities = 23/71 (32%), Positives = 39/71 (54%), Gaps = 5/71 (7%)
Frame = +3
Query: 222 YRLAEIQLCATNV---THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSY 386
Y +A + L N+ H IR ++ KGK+ TQN+D L AG +EK+++ HG+
Sbjct: 138 YNIAHMVLPPENLYSPLHSFIRMIQDKGKLLRNYTQNIDNLESYAGIQAEKMVQCHGSFA 197
Query: 387 LVQCLKCPYEI 419
C+ C +++
Sbjct: 198 TASCVTCHWKL 208
>UniRef50_Q4WFZ3 Cluster: SIR2 family histone deacetylase, putative;
n=4; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Aspergillus fumigatus (Sartorya
fumigata)
Length = 403
Score = 42.7 bits (96), Expect = 0.008
Identities = 22/59 (37%), Positives = 32/59 (54%), Gaps = 4/59 (6%)
Frame = +3
Query: 258 VTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKC--PYEID 422
+TH + LEKKG + + TQN+D L G +K++ HG+ +C KC PY D
Sbjct: 163 ITHAFLALLEKKGLLHFVFTQNIDGLERDVGIPEDKILNAHGSWRTQRCWKCKTPYPDD 221
>UniRef50_Q7QZ36 Cluster: GLP_464_21655_23334; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_464_21655_23334 - Giardia lamblia
ATCC 50803
Length = 559
Score = 42.3 bits (95), Expect = 0.011
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 2/67 (2%)
Frame = +3
Query: 258 VTHLCIRELEKKGKVTSIVTQNVDXLHHKA--GSEKVIELHGTSYLVQCLKCPYEIDRHE 431
V HL +R LEK+G++ I TQN+D L +A + +I HG+ + C+ C +
Sbjct: 234 VVHLFMRLLEKRGQLQRIYTQNIDCLEVQAQITQKYIINCHGSFHTFTCIDCGAKFPMEL 293
Query: 432 LQEILTE 452
L+ + E
Sbjct: 294 LRRTVVE 300
>UniRef50_A2DZ01 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 281
Score = 42.3 bits (95), Expect = 0.011
Identities = 30/84 (35%), Positives = 47/84 (55%), Gaps = 5/84 (5%)
Frame = +3
Query: 258 VTHLCIRELEKKGKVTSIVTQNVDXLHHKAGS--EKVIELHG--TSYLVQCLKCPYEIDR 425
+ H + ++ G V+ ++TQN D LH EKV+ELHG T Y V C KC +E+
Sbjct: 107 LAHNVLHQMVIDGYVSDLLTQNCDSLHSYDDEYDEKVVELHGAATDYGV-CEKC-HELRN 164
Query: 426 HELQEIL-TENNPDMESSFSMIRP 494
++ EIL T+ +P S+++P
Sbjct: 165 VDVLEILHTDTSPVCNVCGSVLKP 188
>UniRef50_Q2H5A0 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 387
Score = 42.3 bits (95), Expect = 0.011
Identities = 26/104 (25%), Positives = 51/104 (49%), Gaps = 3/104 (2%)
Frame = +3
Query: 204 VLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHG 377
VL ++LY A + ++H + L ++G + + TQN+D L AG +++++E HG
Sbjct: 91 VLARELYPGARYR---PTISHAFLALLARRGLLHMLFTQNIDCLERAAGVPADRIVEAHG 147
Query: 378 TSYLVQCLKCPYEIDRHELQEILTENN-PDMESSFSMIRPDGDV 506
+ +C+ C E D ++ + P FS + + D+
Sbjct: 148 SFASQRCVDCKGEFDGEVMRAFVARGEVPRAFFEFSGMTKEADL 191
>UniRef50_A6G0H3 Cluster: Silent information regulator protein Sir2;
n=1; Plesiocystis pacifica SIR-1|Rep: Silent information
regulator protein Sir2 - Plesiocystis pacifica SIR-1
Length = 288
Score = 41.9 bits (94), Expect = 0.015
Identities = 26/61 (42%), Positives = 35/61 (57%), Gaps = 4/61 (6%)
Frame = +3
Query: 219 LYRLAEIQLCATNVTHLCIRELEKK-GKVTSIVTQNVDXLHHKAGS--EKVIELHG-TSY 386
LYR A N H + LE+ G+ +VTQNVD LH +AG+ E+ IE+HG T Y
Sbjct: 85 LYRKGVCNAAAPNPAHEALVRLEQALGERFCLVTQNVDGLHLRAGNSRERTIEVHGNTDY 144
Query: 387 L 389
+
Sbjct: 145 M 145
>UniRef50_A7AWG1 Cluster: Transcriptional regulator, Sir2 family
domain containing protein; n=2; Babesia bovis|Rep:
Transcriptional regulator, Sir2 family domain containing
protein - Babesia bovis
Length = 656
Score = 41.9 bits (94), Expect = 0.015
Identities = 18/50 (36%), Positives = 31/50 (62%), Gaps = 2/50 (4%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSE--KVIELHGTSYLVQCLKC 407
HL L + G + +++TQN+D LH +G + + IELHG ++ +C+ C
Sbjct: 125 HLATLALLRAGYIRTVITQNIDGLHAISGMKHSECIELHGNVFIERCIFC 174
>UniRef50_Q03ZB1 Cluster: NAD-dependent protein deacetylase, SIR2
family; n=3; Leuconostocaceae|Rep: NAD-dependent protein
deacetylase, SIR2 family - Leuconostoc mesenteroides
subsp. mesenteroides (strain ATCC 8293 /NCDO 523)
Length = 234
Score = 41.5 bits (93), Expect = 0.019
Identities = 23/46 (50%), Positives = 29/46 (63%), Gaps = 2/46 (4%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGS--EKVIELHGTSY 386
NV H + L ++GK I+TQNVD LH KA S EK+I HG+ Y
Sbjct: 80 NVIHKKMAALTRQGKA-KIITQNVDDLHVKAASDPEKLIRFHGSLY 124
>UniRef50_A1ZPG8 Cluster: NAD-dependent deacetylase; n=1;
Microscilla marina ATCC 23134|Rep: NAD-dependent
deacetylase - Microscilla marina ATCC 23134
Length = 278
Score = 41.5 bits (93), Expect = 0.019
Identities = 26/73 (35%), Positives = 37/73 (50%), Gaps = 3/73 (4%)
Frame = +3
Query: 189 ESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKK-GKVTSIVTQNVDXLHHKAGS--EK 359
E+ A+V LYR + N HL + E ++TQN+D LH KAG+ K
Sbjct: 66 ENPAEVWKFVLYRKVSFRDLQPNAGHLALASTEVLLPNNFRLITQNIDRLHIKAGNTQAK 125
Query: 360 VIELHGTSYLVQC 398
V+E+HG V+C
Sbjct: 126 VLEIHGNMETVRC 138
>UniRef50_Q54P49 Cluster: Zn finger-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: Zn finger-containing
protein - Dictyostelium discoideum AX4
Length = 456
Score = 41.5 bits (93), Expect = 0.019
Identities = 38/136 (27%), Positives = 59/136 (43%), Gaps = 2/136 (1%)
Frame = +3
Query: 207 LGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGS--EKVIELHGT 380
L K LY + + C H I+ L KG + QN D L AG +K+IE HG+
Sbjct: 240 LSKDLYPSGKFK-CTP--VHYFIKLLSDKGLLLRNYAQNADTLERIAGIPLDKLIEAHGS 296
Query: 381 SYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSV 560
+ +C C E + +++ + N+P + P C+ Q
Sbjct: 297 FAVSRCTNCGLEYSQEYIKDSIFNNDP-----LKSVVP----RCK----------VVQCN 337
Query: 561 KGPLKPDIVFFGDNVP 608
+KPDIVFFG+++P
Sbjct: 338 NAVIKPDIVFFGESLP 353
>UniRef50_A2DKF0 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 347
Score = 41.5 bits (93), Expect = 0.019
Identities = 22/60 (36%), Positives = 31/60 (51%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEIDRHELQE 440
TH I ELE GK+ + +QNVD L K+ +HG+ CL C + D +L+E
Sbjct: 138 THYFIAELENHGKLQRLYSQNVDTLECGVPESKLRCVHGSWRNSYCLSCGKKFDIEDLRE 197
>UniRef50_Q885X7 Cluster: NAD-dependent deacetylase 2; n=4;
Pseudomonas|Rep: NAD-dependent deacetylase 2 -
Pseudomonas syringae pv. tomato
Length = 248
Score = 41.5 bits (93), Expect = 0.019
Identities = 21/53 (39%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGS--EKVIELHGTSYLVQCLKC 407
NV H I +L++ ++TQNVD H AGS E++IE+HG + C C
Sbjct: 81 NVAHYAIAQLQRIKPECWVLTQNVDGYHRAAGSPPERLIEIHGQLSPLFCQSC 133
>UniRef50_Q25337 Cluster: NAD-dependent deacetylase SIR2 homolog;
n=6; Leishmania|Rep: NAD-dependent deacetylase SIR2
homolog - Leishmania major
Length = 381
Score = 41.1 bits (92), Expect = 0.025
Identities = 21/62 (33%), Positives = 36/62 (58%), Gaps = 4/62 (6%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKC--PYEIDRHE 431
H IR L+ +G++ TQN+D L AG E ++E HG+ C++C P+ I+++
Sbjct: 106 HHFIRLLQDEGRLLRCCTQNIDGLEKAAGVSPELLVEAHGSFAAAACIECHTPFSIEQNY 165
Query: 432 LQ 437
L+
Sbjct: 166 LE 167
>UniRef50_O59923 Cluster: NAD-dependent histone deacetylase SIR2;
n=3; Candida albicans|Rep: NAD-dependent histone
deacetylase SIR2 - Candida albicans (Yeast)
Length = 515
Score = 41.1 bits (92), Expect = 0.025
Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 5/71 (7%)
Frame = +3
Query: 210 GKKLYRLAEIQLCAT---NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELH 374
G+ Y +A + L ++ H ++ L+ K K+ TQN+D L +AG SEK+++ H
Sbjct: 285 GRLFYTIAHLVLPPDGKFSLLHAFLKLLQDKHKLLRNYTQNIDNLEQRAGLKSEKLVQCH 344
Query: 375 GTSYLVQCLKC 407
G+ +C+ C
Sbjct: 345 GSFAKAKCVSC 355
>UniRef50_UPI0000D573CE Cluster: PREDICTED: similar to CG11305-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG11305-PA - Tribolium castaneum
Length = 627
Score = 40.7 bits (91), Expect = 0.034
Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Frame = +3
Query: 234 EIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEK--VIELHGTSYLVQCLKC 407
++ + TH+ + EL + + +V+QN D LH ++G + + ELHG Y+ C C
Sbjct: 159 DLSMAEPTYTHMALSELYRNKILKYVVSQNCDGLHLRSGLPRTALSELHGNMYIEVCKTC 218
Query: 408 PYEIDRHELQEILTEN 455
+ L ++ TEN
Sbjct: 219 KPHKEYWRLFDV-TEN 233
>UniRef50_A0C6J0 Cluster: Chromosome undetermined scaffold_152,
whole genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_152,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 449
Score = 40.7 bits (91), Expect = 0.034
Identities = 18/56 (32%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Frame = +3
Query: 258 VTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEI 419
+ H ++ L+ +G++ TQN+D L AG +KVI+ HG +C++C E+
Sbjct: 281 LAHKFLKFLDSRGQLLKCFTQNIDGLELDAGVSQDKVIQAHGHMRTARCIECQEEV 336
>UniRef50_Q9USN7 Cluster: Sir2 family histone deacetylase Hst2; n=1;
Schizosaccharomyces pombe|Rep: Sir2 family histone
deacetylase Hst2 - Schizosaccharomyces pombe (Fission
yeast)
Length = 332
Score = 40.7 bits (91), Expect = 0.034
Identities = 27/82 (32%), Positives = 40/82 (48%), Gaps = 4/82 (4%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
TH IR L K + TQN+D L AG + +IE HG+ +C++C YE+ E
Sbjct: 99 THYFIRLLHDKRLLQKCYTQNIDTLERLAGVPDKALIEAHGSFQYSRCIEC-YEMAETEY 157
Query: 435 QE--ILTENNPDMESSFSMIRP 494
I+ + P S +I+P
Sbjct: 158 VRACIMQKQVPKCNSCKGLIKP 179
>UniRef50_A1ZHW6 Cluster: NAD-dependent deacetylase; n=2;
Microscilla marina ATCC 23134|Rep: NAD-dependent
deacetylase - Microscilla marina ATCC 23134
Length = 279
Score = 40.3 bits (90), Expect = 0.044
Identities = 23/54 (42%), Positives = 32/54 (59%), Gaps = 4/54 (7%)
Frame = +3
Query: 255 NVTHLCIRELEK--KGKVTSIVTQNVDXLHHKAGS--EKVIELHGTSYLVQCLK 404
N H + E+EK GK ++VTQNVD LH +AGS + + +HG V+C K
Sbjct: 87 NPGHYAVAEMEKILGGKRFTLVTQNVDGLHFRAGSTFKNTLLIHGDLTHVRCSK 140
>UniRef50_A4RCT8 Cluster: Putative uncharacterized protein; n=3;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 1040
Score = 40.3 bits (90), Expect = 0.044
Identities = 21/61 (34%), Positives = 35/61 (57%), Gaps = 2/61 (3%)
Frame = +3
Query: 222 YRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQ 395
YR E N H + EL +K +++TQNVD L +AG +++++ELHG + ++
Sbjct: 87 YRREEALKAQPNKAHRALAELARKVPGFTMLTQNVDNLSPRAGHPADQLLELHGNLFDLK 146
Query: 396 C 398
C
Sbjct: 147 C 147
>UniRef50_Q9VAQ1 Cluster: CG11305-PA; n=8; Coelomata|Rep: CG11305-PA
- Drosophila melanogaster (Fruit fly)
Length = 771
Score = 39.5 bits (88), Expect = 0.078
Identities = 17/51 (33%), Positives = 29/51 (56%), Gaps = 2/51 (3%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKC 407
TH+ + EL ++ + +V+QN D LH ++G + E+HG Y+ C C
Sbjct: 172 THMALYELHRRRLLHHVVSQNCDGLHLRSGLPRNSLSEIHGNMYVEVCKNC 222
>UniRef50_Q7R0G2 Cluster: GLP_29_33086_34261; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_29_33086_34261 - Giardia lamblia
ATCC 50803
Length = 391
Score = 39.5 bits (88), Expect = 0.078
Identities = 18/51 (35%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGS--EKVIELHGTSYLVQCL 401
N H+ I ++ +K V ++TQN+D LH K+G+ +++E+HG L +C+
Sbjct: 126 NQGHIAIAKIMRKADVF-VITQNIDTLHTKSGALENRLVEIHGRLGLYKCV 175
>UniRef50_Q8FRV5 Cluster: NAD-dependent deacetylase 2; n=9;
Corynebacterineae|Rep: NAD-dependent deacetylase 2 -
Corynebacterium efficiens
Length = 254
Score = 39.5 bits (88), Expect = 0.078
Identities = 15/33 (45%), Positives = 22/33 (66%)
Frame = +3
Query: 309 IVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKC 407
+ TQN+D LH +AGS +V LHG+ + +C C
Sbjct: 102 VTTQNIDNLHERAGSTEVTHLHGSLFEFRCSIC 134
>UniRef50_UPI0000E49AD8 Cluster: PREDICTED: similar to NAD-dependent
deacetylase sirtuin 2 homolog; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to NAD-dependent
deacetylase sirtuin 2 homolog - Strongylocentrotus
purpuratus
Length = 400
Score = 39.1 bits (87), Expect = 0.10
Identities = 38/118 (32%), Positives = 53/118 (44%), Gaps = 2/118 (1%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHEL 434
+H I L +KG + TQN+D L AG E ++E HG+ + CL C
Sbjct: 145 SHFFIHLLHEKGILLRHYTQNIDGLDRMAGVPDELIMEAHGSFHTGHCLNC--------- 195
Query: 435 QEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
E+ TE ES I D C K +E G +KPD+VFFG+++P
Sbjct: 196 NEMYTE-----ESMREKIMADLIPRCA----KCNE-------TGVVKPDVVFFGESLP 237
>UniRef50_A5WD15 Cluster: Silent information regulator protein Sir2;
n=2; Psychrobacter|Rep: Silent information regulator
protein Sir2 - Psychrobacter sp. PRwf-1
Length = 249
Score = 39.1 bits (87), Expect = 0.10
Identities = 23/66 (34%), Positives = 35/66 (53%), Gaps = 4/66 (6%)
Frame = +3
Query: 222 YRLAEIQLCATNVTHLCIRELEK----KGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYL 389
+R +Q N H + L++ K S++TQNVD LH +AGS+ I LHG +
Sbjct: 70 WRRGLVQDKQPNPAHYALANLQQWATDNHKDCSLITQNVDDLHEQAGSQ-AIHLHGHLWK 128
Query: 390 VQCLKC 407
+C +C
Sbjct: 129 NKCSQC 134
>UniRef50_A1ZMS1 Cluster: Silent information regulator protein Sir2;
n=1; Microscilla marina ATCC 23134|Rep: Silent
information regulator protein Sir2 - Microscilla marina
ATCC 23134
Length = 276
Score = 39.1 bits (87), Expect = 0.10
Identities = 19/56 (33%), Positives = 34/56 (60%), Gaps = 3/56 (5%)
Frame = +3
Query: 312 VTQNVDXLHHKAGS--EKVIELHGTSYLVQC-LKCPYEIDRHELQEILTENNPDME 470
+T N+D H KAG+ +KV E+HG+ + +QC + C E+ + E + NN +++
Sbjct: 108 ITSNIDGQHLKAGATKDKVREVHGSIFHLQCSVPCHQEVWEGDTNEAIDVNNENLQ 163
>UniRef50_Q6BVM7 Cluster: Similar to CA4170|IPF7784 Candida
albicans; n=2; Saccharomycetaceae|Rep: Similar to
CA4170|IPF7784 Candida albicans - Debaryomyces hansenii
(Yeast) (Torulaspora hansenii)
Length = 301
Score = 38.7 bits (86), Expect = 0.14
Identities = 26/80 (32%), Positives = 42/80 (52%), Gaps = 5/80 (6%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSI-VTQNVDXLHHKAG--SEKVIELHGTSYLVQC--LKCPYEI 419
N HL + +L K + + +TQNVD L +AG EK+ E+HG+ + ++C C Y +
Sbjct: 80 NKGHLALAKLSKLSNIEFMTITQNVDGLLIRAGHPKEKLHEIHGSLFDLRCTSFMCNY-V 138
Query: 420 DRHELQEILTENNPDMESSF 479
D + LT+ D E +
Sbjct: 139 DHDNFKNPLTKALADTEFEY 158
>UniRef50_UPI00015B56BB Cluster: PREDICTED: similar to
ENSANGP00000025716; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000025716 - Nasonia
vitripennis
Length = 581
Score = 38.3 bits (85), Expect = 0.18
Identities = 18/52 (34%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Frame = +3
Query: 258 VTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVI--ELHGTSYLVQCLKC 407
+TH+ + L K + IV+QN D LH ++G + + E+HG Y+ C C
Sbjct: 158 ITHMALYALYKARMLKHIVSQNCDGLHLRSGIPRPLLSEVHGNMYVEVCRTC 209
>UniRef50_Q55DB0 Cluster: NAD(+)-dependent deacetylase, silent
information regulator protein (Sir2) family protein;
n=1; Dictyostelium discoideum AX4|Rep: NAD(+)-dependent
deacetylase, silent information regulator protein (Sir2)
family protein - Dictyostelium discoideum AX4
Length = 346
Score = 38.3 bits (85), Expect = 0.18
Identities = 25/61 (40%), Positives = 36/61 (59%), Gaps = 5/61 (8%)
Frame = +3
Query: 255 NVTHLCIRE-LEKKGKVTSIVTQNVDXLHHKA--GSEKVIELHGTSYLVQCLK--CPYEI 419
N HL I +E G ++++TQNVD LH KA EK++E+HG L +C+ C +E
Sbjct: 112 NSGHLAISNFVEYLG--SNVITQNVDALHLKAKVPIEKLVEVHGRISLYKCITKGCRFEY 169
Query: 420 D 422
D
Sbjct: 170 D 170
>UniRef50_O94066 Cluster: Transcription regulatory protein; n=6;
Saccharomycetales|Rep: Transcription regulatory protein
- Candida albicans (Yeast)
Length = 331
Score = 38.3 bits (85), Expect = 0.18
Identities = 41/138 (29%), Positives = 64/138 (46%), Gaps = 6/138 (4%)
Frame = +3
Query: 213 KKLYRLAEIQLCATNVT----HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEK--VIELH 374
K Y LAE +L N H I+ L+ +G + + TQN+D L AG E ++E H
Sbjct: 71 KPFYTLAE-ELYPGNFAPTKFHHFIKLLQDQGSLKRVYTQNIDTLERLAGVEDKYIVEAH 129
Query: 375 GTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQ 554
G+ C +D H+ E+ TE +++ K+ ++ S Q
Sbjct: 130 GSFASNHC------VDCHK--EMTTET---LKTYM----------------KDKKIPSCQ 162
Query: 555 SVKGPLKPDIVFFGDNVP 608
+G +KPDIVFFG+ +P
Sbjct: 163 HCEGYVKPDIVFFGEGLP 180
>UniRef50_Q23E36 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 1348
Score = 37.9 bits (84), Expect = 0.24
Identities = 18/63 (28%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H + E+ ++ ++ + +QNVD L +AG EK+ ++HG +C KC ++ D ++ +
Sbjct: 92 HYFMAEVNRREQLLFVFSQNVDGLELEAGLPPEKLCQVHGNYRGARCQKCGFKHDINKYK 151
Query: 438 EIL 446
E +
Sbjct: 152 EFV 154
>UniRef50_A2DKY5 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 180
Score = 37.9 bits (84), Expect = 0.24
Identities = 21/78 (26%), Positives = 34/78 (43%), Gaps = 2/78 (2%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKA--GSEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H+ IR +E+ G + T N D L A KV++ HG+ C+ C E+ +E
Sbjct: 95 HILIRLIEEMGLLRRWYTTNTDCLELDAIKDKSKVVQCHGSVKHCHCIDCGAEVSMNECL 154
Query: 438 EILTENNPDMESSFSMIR 491
+ N E F ++
Sbjct: 155 SAIRGNYGRKEKGFDFVK 172
>UniRef50_A0D0F1 Cluster: Chromosome undetermined scaffold_33, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_33,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 264
Score = 37.9 bits (84), Expect = 0.24
Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 2/71 (2%)
Frame = +3
Query: 309 IVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQEILTENNPDMESSFS 482
++T NVD KAG S + E+HG+ + QC C D H+ +++ + D+E FS
Sbjct: 97 VITSNVDGQFQKAGFDSNHIYEMHGSIHKFQCTPCDKLYDAHQFKDL----SIDLE-KFS 151
Query: 483 MIRPDGDVDCR 515
P +C+
Sbjct: 152 AADPLPKCECK 162
>UniRef50_Q21KQ1 Cluster: Silent information regulator protein Sir2;
n=2; Gammaproteobacteria|Rep: Silent information
regulator protein Sir2 - Saccharophagus degradans
(strain 2-40 / ATCC 43961 / DSM 17024)
Length = 235
Score = 37.5 bits (83), Expect = 0.31
Identities = 24/69 (34%), Positives = 33/69 (47%), Gaps = 5/69 (7%)
Frame = +3
Query: 207 LGKKLYRLAEIQLCAT---NVTHLCIRELEK--KGKVTSIVTQNVDXLHHKAGSEKVIEL 371
L +K Y QL N H + E E+ G+ +VTQNVD LH GS+ +I +
Sbjct: 54 LVQKFYNARRSQLLTAAQPNKAHTALGEFEQHFSGEFL-LVTQNVDNLHELGGSKNLIHM 112
Query: 372 HGTSYLVQC 398
HG +C
Sbjct: 113 HGELLKARC 121
>UniRef50_UPI0000499DEA Cluster: Sir2 family transcriptional
regulator; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
Sir2 family transcriptional regulator - Entamoeba
histolytica HM-1:IMSS
Length = 383
Score = 37.1 bits (82), Expect = 0.41
Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 2/50 (4%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKC 407
H ++ L KG + + TQN+D L AG ++KVI HGT CL C
Sbjct: 209 HRFLKLLNDKGILKMVYTQNIDGLESVAGIPNDKVICSHGTFRSSHCLSC 258
>UniRef50_Q75DM1 Cluster: ABL004Wp; n=1; Eremothecium gossypii|Rep:
ABL004Wp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 319
Score = 37.1 bits (82), Expect = 0.41
Identities = 20/56 (35%), Positives = 31/56 (55%), Gaps = 4/56 (7%)
Frame = +3
Query: 258 VTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEK--VIELHGTSYLVQCLK--CPY 413
+ LC R + + +VTQNVD LH +AG + +ELHG+ + +C + C Y
Sbjct: 89 LAELCRRVAADERREILLVTQNVDGLHWRAGQPEASTVELHGSVFDYRCTEFLCSY 144
>UniRef50_Q7S223 Cluster: Putative uncharacterized protein
NCU05973.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU05973.1 - Neurospora crassa
Length = 334
Score = 36.7 bits (81), Expect = 0.55
Identities = 26/88 (29%), Positives = 41/88 (46%), Gaps = 5/88 (5%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYE---I 419
N H + L KK +TQNVD L +AG +++ LHG+ + +QC P + I
Sbjct: 83 NAGHHALAALAKKNPNFLCLTQNVDNLSSRAGHQQQQLHTLHGSLFTLQCSSYPSQCTYI 142
Query: 420 DRHELQEILTENNPDMESSFSMIRPDGD 503
D++ + L +S S+ P D
Sbjct: 143 DKNNTLDPLCPALAPASASASINPPSND 170
>UniRef50_A2GAR7 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 312
Score = 36.3 bits (80), Expect = 0.72
Identities = 31/111 (27%), Positives = 52/111 (46%), Gaps = 2/111 (1%)
Frame = +3
Query: 285 EKKGKVTSIVTQNVDXLHHKAGS--EKVIELHGTSYLVQCLKCPYEIDRHELQEILTENN 458
+K +T + TQN+D L AG +K++E HG+ + C KC + + + +E
Sbjct: 113 DKHKLLTRLYTQNIDSLDISAGLPLDKIVEAHGSFTYLTCRKCGSKFEFADYKE------ 166
Query: 459 PDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQ 611
E + V CR K +G +KPD+VF+G+++PQ
Sbjct: 167 ---EFQTGKV-----VHCRECK------------EGVIKPDVVFYGEDLPQ 197
>UniRef50_Q8SSB6 Cluster: SIR2-LIKE PROTEIN INVOLVED IN TELOMERIC
SILENCING; n=1; Encephalitozoon cuniculi|Rep: SIR2-LIKE
PROTEIN INVOLVED IN TELOMERIC SILENCING -
Encephalitozoon cuniculi
Length = 425
Score = 36.3 bits (80), Expect = 0.72
Identities = 26/96 (27%), Positives = 47/96 (48%), Gaps = 7/96 (7%)
Frame = +3
Query: 156 TYTVSRICEVSESKAKVLGKKLYRLAEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXL 335
TY++S E+ + + + K + + Q AT+ ++ ++ + I TQN+D L
Sbjct: 128 TYSLSMSKELRKGYLRYISKLKNMVDKAQPSATHEFLSLYSDISRRFR---IYTQNIDGL 184
Query: 336 HHKAG-------SEKVIELHGTSYLVQCLKCPYEID 422
KAG S +++ LHG + CL C Y+I+
Sbjct: 185 EEKAGLAATKDRSTRLVYLHGNMKSLGCLYCGYKIE 220
>UniRef50_A1CD03 Cluster: SIR2 family histone deacetylase, putative;
n=2; Trichocomaceae|Rep: SIR2 family histone
deacetylase, putative - Aspergillus clavatus
Length = 329
Score = 36.3 bits (80), Expect = 0.72
Identities = 32/120 (26%), Positives = 49/120 (40%), Gaps = 3/120 (2%)
Frame = +3
Query: 258 VTHLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHE 431
+TH + L KK + + TQN+D L G K++ HG+ C KC
Sbjct: 87 ITHAFLALLAKKNLLHFLFTQNIDGLERDTGVPENKILNAHGSWRTQHCWKCKTSYPDDL 146
Query: 432 LQEILTENNPDMESSFSMIRPDGDV-DCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVP 608
++E + + + P V DC G P+KPD+VFFG ++P
Sbjct: 147 MKEAIAKG----------VVPYCQVPDCGG----------------PIKPDVVFFGQSLP 180
>UniRef50_A6Q2C0 Cluster: Transcriptional regulator, Sir2 family;
n=2; Bacteria|Rep: Transcriptional regulator, Sir2
family - Nitratiruptor sp. (strain SB155-2)
Length = 268
Score = 35.9 bits (79), Expect = 0.96
Identities = 17/44 (38%), Positives = 28/44 (63%), Gaps = 2/44 (4%)
Frame = +3
Query: 279 ELEKKGKVTSIVTQNVDXLHHKAGSE--KVIELHGTSYLVQCLK 404
E+ ++ K +VT NVD KAG + K+ E+HG+ + +QC+K
Sbjct: 93 EIAQRKKEYFVVTSNVDGQFQKAGFDEMKIDEVHGSIHYLQCIK 136
>UniRef50_Q6CQA7 Cluster: Kluyveromyces lactis strain NRRL Y-1140
chromosome D of strain NRRL Y- 1140 of Kluyveromyces
lactis; n=1; Kluyveromyces lactis|Rep: Kluyveromyces
lactis strain NRRL Y-1140 chromosome D of strain NRRL Y-
1140 of Kluyveromyces lactis - Kluyveromyces lactis
(Yeast) (Candida sphaerica)
Length = 399
Score = 35.9 bits (79), Expect = 0.96
Identities = 31/125 (24%), Positives = 60/125 (48%), Gaps = 9/125 (7%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHK----AGSE-----KVIELHGTSYLVQCLKCPYE 416
H I +L +K +V I +QN+D L K + +E +V++LHG+ + + C+KC
Sbjct: 191 HSFINQLCEKNQVKRIYSQNIDGLETKFQTTSANESPKNPQVVQLHGSIHHMSCMKCR-- 248
Query: 417 IDRHELQEILTENNPDMESSFSMIRPDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFG 596
++++ + + + D E+ I P +C+ + S G LKP +V +
Sbjct: 249 -KKYDMDPSMFKTDEDAET--GEIVPQCP-ECKEFESVRSVCGKRLQGVGRLKPSVVLYN 304
Query: 597 DNVPQ 611
+ P+
Sbjct: 305 EYHPE 309
>UniRef50_Q4PG00 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 596
Score = 35.9 bits (79), Expect = 0.96
Identities = 17/63 (26%), Positives = 32/63 (50%), Gaps = 2/63 (3%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCL--KCPYEIDRHELQ 437
H I+ +E++G++ +QN+D L G E+V++ HG+ C C + E+
Sbjct: 265 HRFIKLIEERGQLLRNYSQNIDTLEQLVGIERVLQCHGSFASASCTDPTCGFRCKGSEIA 324
Query: 438 EIL 446
E +
Sbjct: 325 EAI 327
>UniRef50_Q9RYD4 Cluster: NAD-dependent deacetylase; n=4;
Deinococci|Rep: NAD-dependent deacetylase - Deinococcus
radiodurans
Length = 246
Score = 35.9 bits (79), Expect = 0.96
Identities = 22/56 (39%), Positives = 31/56 (55%), Gaps = 5/56 (8%)
Frame = +3
Query: 225 RLAEIQLCATNVTHLCIRELEK-KGKVTSIVTQNVDXLHHKAGS----EKVIELHG 377
R ++ N H + ELE+ KG + TQNVD LH +AGS +++ELHG
Sbjct: 69 RYRDVLAAQPNRGHELLAELERRKGPGFFLATQNVDGLHARAGSGSAGGELVELHG 124
>UniRef50_Q5KPC9 Cluster: Hst3 protein, putative; n=2;
Filobasidiella neoformans|Rep: Hst3 protein, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 389
Score = 35.5 bits (78), Expect = 1.3
Identities = 22/62 (35%), Positives = 31/62 (50%), Gaps = 13/62 (20%)
Frame = +3
Query: 261 THLCIRELEKKGKVTSIVTQNVDXLHHKAGSE-------------KVIELHGTSYLVQCL 401
TH IR+LE+KGK+ TQN+D + G E + +ELHG V+C+
Sbjct: 113 THHFIRKLEQKGKLLRSYTQNIDGFERRMGLESGGRGKGLKKKETRNVELHGDLGRVRCV 172
Query: 402 KC 407
C
Sbjct: 173 LC 174
>UniRef50_Q7VIN2 Cluster: NAD-dependent deacetylase; n=1;
Helicobacter hepaticus|Rep: NAD-dependent deacetylase -
Helicobacter hepaticus
Length = 255
Score = 35.5 bits (78), Expect = 1.3
Identities = 16/37 (43%), Positives = 21/37 (56%)
Frame = +3
Query: 312 VTQNVDXLHHKAGSEKVIELHGTSYLVQCLKCPYEID 422
+TQNVD L +AG VI LHG + C +C + D
Sbjct: 101 ITQNVDDLLERAGVSNVIHLHGELCKIICPQCEHIFD 137
>UniRef50_A7HID4 Cluster: Silent information regulator protein Sir2;
n=9; Deltaproteobacteria|Rep: Silent information
regulator protein Sir2 - Anaeromyxobacter sp. Fw109-5
Length = 289
Score = 35.1 bits (77), Expect = 1.7
Identities = 18/46 (39%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Frame = +3
Query: 267 LCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQC 398
L +R ++ G +VT NVD KAG E+V+E+HG+ + +QC
Sbjct: 93 LLLRWSQRLGLPCFVVTSNVDGQFQKAGFAEEQVLEVHGSIHHLQC 138
>UniRef50_A6DES9 Cluster: Transcriptional regulator, Sir2 family
protein; n=2; Epsilonproteobacteria|Rep: Transcriptional
regulator, Sir2 family protein - Caminibacter
mediatlanticus TB-2
Length = 264
Score = 35.1 bits (77), Expect = 1.7
Identities = 19/40 (47%), Positives = 26/40 (65%), Gaps = 3/40 (7%)
Frame = +3
Query: 309 IVTQNVDXLHHKAG-SE-KVIELHGTSYLVQCLK-CPYEI 419
+ T NVD KAG SE K++E+HG+ + +QC K C EI
Sbjct: 102 VFTSNVDGQFQKAGFSEMKIVEIHGSIHYLQCTKPCKQEI 141
>UniRef50_Q22ZC3 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Tetrahymena thermophila SB210|Rep:
Transcriptional regulator, Sir2 family protein -
Tetrahymena thermophila SB210
Length = 308
Score = 35.1 bits (77), Expect = 1.7
Identities = 16/55 (29%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEID 422
H I ++ K+ ++ +TQN+D L K G KV++ HG C+ C + ++
Sbjct: 141 HKLIHQIYKRKQLLINITQNIDGLELKTGINPSKVVQAHGHMRKAHCVNCNHIVN 195
>UniRef50_A2F8N6 Cluster: Transcriptional regulator, Sir2 family
protein; n=1; Trichomonas vaginalis G3|Rep:
Transcriptional regulator, Sir2 family protein -
Trichomonas vaginalis G3
Length = 320
Score = 35.1 bits (77), Expect = 1.7
Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 3/81 (3%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKCPYEIDRHELQ 437
H + E G + +QN+D L AG E ++E HGT C KC + +++
Sbjct: 109 HFLAKLFENHGILLRHYSQNIDGLDKAAGLSEEHLVEWHGTLSKATCRKCSKKYTLDDIK 168
Query: 438 -EILTENNPDMESSFSMIRPD 497
+IL E P S +I+PD
Sbjct: 169 PKILAEAVPRC-SCGGVIQPD 188
>UniRef50_A0C2R2 Cluster: Chromosome undetermined scaffold_145,
whole genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_145,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 258
Score = 34.7 bits (76), Expect = 2.2
Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 2/50 (4%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAG--SEKVIELHGTSYLVQCLKC 407
H I L++ ++ + TQN+D L AG KVI++HG C+ C
Sbjct: 92 HQFIYHLDRNDQLLNCFTQNIDGLELVAGVRESKVIQVHGHRRTASCIDC 141
>UniRef50_Q754T1 Cluster: AFL010Cp; n=1; Eremothecium gossypii|Rep:
AFL010Cp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 252
Score = 34.7 bits (76), Expect = 2.2
Identities = 16/50 (32%), Positives = 26/50 (52%)
Frame = -3
Query: 168 ILYRFVITTGIQTNILRSVVRNT*RPLTLLVYYFTEDTVRSVKNVQ*KFY 19
+LYR TG+ T L +R +P LL Y T D + ++K + ++Y
Sbjct: 43 LLYRLEYYTGVLTKDLEDTIRRLQKPAELLNYSVTSDDIGNMKTTRLEYY 92
>UniRef50_A7TCJ5 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 309
Score = 34.3 bits (75), Expect = 2.9
Identities = 25/89 (28%), Positives = 45/89 (50%), Gaps = 2/89 (2%)
Frame = -1
Query: 668 ITNTASL--LVTSFLTCSHAILGYIVTKKHYIWFQRPLHTLGRVELGIFLLVPSTINIAI 495
ITN+ SL ++ SFL + ++ + Y+ + + R +G+ L VPS N +
Sbjct: 177 ITNSPSLNNMLFSFLAVNIIVIAFC-----YVNVYKAIRC-HRKRVGVSLRVPSLTNSHL 230
Query: 494 RSYHGETTFHIWIILC*YFLEFMSVYFIG 408
R T++ I+II+C Y F+ + +G
Sbjct: 231 RPEDVHTSYTIFIIICLYGFCFLPTFILG 259
>UniRef50_Q2KH01 Cluster: Putative uncharacterized protein; n=2;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea 70-15
Length = 449
Score = 33.9 bits (74), Expect = 3.9
Identities = 16/45 (35%), Positives = 23/45 (51%), Gaps = 2/45 (4%)
Frame = +3
Query: 282 LEKKGKVTSIVTQNVDXLHHK--AGSEKVIELHGTSYLVQCLKCP 410
LE++ + +TQN+D L A K + LHG V+C CP
Sbjct: 162 LEEQPSIVLHITQNIDCLERSLPAAERKTVRLHGCLDTVRCSVCP 206
>UniRef50_A2DZ29 Cluster: Transcriptional regulator, Sir2 family
protein; n=4; Trichomonas vaginalis|Rep: Transcriptional
regulator, Sir2 family protein - Trichomonas vaginalis
G3
Length = 375
Score = 33.5 bits (73), Expect = 5.1
Identities = 17/48 (35%), Positives = 25/48 (52%)
Frame = +3
Query: 264 HLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVIELHGTSYLVQCLKC 407
H + LEK+GK+ + TQNVD L E + +HG+ C+ C
Sbjct: 161 HYFLENLEKRGKLLRLYTQNVDALDVGILPEHLRCVHGSWRESYCMTC 208
>UniRef50_Q7R0R8 Cluster: GLP_79_6121_4343; n=1; Giardia lamblia
ATCC 50803|Rep: GLP_79_6121_4343 - Giardia lamblia ATCC
50803
Length = 592
Score = 33.1 bits (72), Expect = 6.7
Identities = 29/99 (29%), Positives = 48/99 (48%), Gaps = 10/99 (10%)
Frame = +3
Query: 255 NVTHLCIRELEKKGKVTSIVTQNVDXLHHKAGSEKVI---ELHGT-SYLVQCLKCPYE-I 419
++TH +R L +G + I+TQN+D L G +V+ ++HG+ S CL C +
Sbjct: 164 SLTHYFLRFLADEGILKLILTQNIDELERGVGLSEVVDVKQVHGSLSNPGACLACGRSCL 223
Query: 420 DRHELQEILTENNPDMESSFSMIRP-----DGDVDCRGN 521
LQ I + E+ S I+P D D+D + +
Sbjct: 224 PEVVLQAIRDGSVAACENCGSAIKPGIVCYDEDIDLQSD 262
>UniRef50_A7BW37 Cluster: Putative uncharacterized protein; n=1;
Beggiatoa sp. PS|Rep: Putative uncharacterized protein -
Beggiatoa sp. PS
Length = 157
Score = 32.7 bits (71), Expect = 8.9
Identities = 12/22 (54%), Positives = 17/22 (77%)
Frame = -3
Query: 501 RHPVLSWRNYFPYLDYSLLIFL 436
+HPV S+ NYFP+ D+ L+I L
Sbjct: 52 QHPVESYLNYFPFRDFDLIILL 73
>UniRef50_A2F1E9 Cluster: Putative uncharacterized protein; n=1;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 308
Score = 32.7 bits (71), Expect = 8.9
Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 5/54 (9%)
Frame = -2
Query: 205 TFALLSDTSQILDTV*VCDYYGHTDQHPPICSQEYLTTTNF-----ISVLLHRG 59
TFA + +Q+++ + C +Y D HPP CS + N+ I +LL RG
Sbjct: 166 TFAARKEDNQLIEEL--CRHYNDVDLHPPGCSTALWLSANYGNSEGIRILLDRG 217
>UniRef50_P53687 Cluster: NAD-dependent histone deacetylase HST3;
n=6; Saccharomycetales|Rep: NAD-dependent histone
deacetylase HST3 - Saccharomyces cerevisiae (Baker's
yeast)
Length = 447
Score = 32.7 bits (71), Expect = 8.9
Identities = 41/165 (24%), Positives = 65/165 (39%), Gaps = 21/165 (12%)
Frame = +3
Query: 195 KAKVLGKKLYRL-AEIQLCATNVTHLCIRELEKKGKVTSIVTQNVDXLHHKAG------- 350
K + K + RL + +QL TH I L+ + K+ TQN+D L G
Sbjct: 109 KISIFAKFMERLYSNVQLAKPTKTHKFIAHLKDRNKLLRCYTQNIDGLEESIGLTLSNRK 168
Query: 351 -----------SEKVIELHGTSYLVQCLKC--PYEIDRHELQEILTENNPDMESSFSMIR 491
+ V++LHG + C KC + R+ + + P +
Sbjct: 169 LPLTSFSSHWKNLDVVQLHGDLKTLSCTKCFQTFPWSRYWSRCLRRGELP--------LC 220
Query: 492 PDGDVDCRGNK*KNSELHSAQSVKGPLKPDIVFFGDNVPQYRVGT 626
P D + NK N + S G L+P+IV +G+N P + T
Sbjct: 221 P--DCEALINKRLNEGKRTLGSNVGILRPNIVLYGENHPSCEIIT 263
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 722,174,829
Number of Sequences: 1657284
Number of extensions: 15393567
Number of successful extensions: 37066
Number of sequences better than 10.0: 231
Number of HSP's better than 10.0 without gapping: 35474
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 36977
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 55371905986
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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