Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= rbmte13p12
(756 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC037798-1|AAH37798.1| 176|Homo sapiens TPPP3 protein protein. 101 3e-21
BC000691-1|AAH00691.1| 176|Homo sapiens brain specific protein ... 101 3e-21
AF132972-1|AAD27747.1| 176|Homo sapiens CGI-38 protein protein. 101 3e-21
BT020035-1|AAV38838.1| 219|Homo sapiens brain-specific protein ... 91 4e-18
BC131506-1|AAI31507.1| 219|Homo sapiens tubulin polymerization ... 91 4e-18
BC040496-1|AAH40496.1| 234|Homo sapiens TPPP protein protein. 91 4e-18
AY319261-1|AAQ96657.1| 219|Homo sapiens fibroblast growth facto... 91 4e-18
AB017016-1|BAA36164.1| 219|Homo sapiens p25 alpha protein. 91 4e-18
BC038970-1|AAH38970.1| 170|Homo sapiens tubulin polymerization-... 87 5e-17
AY173946-1|AAO49716.1| 170|Homo sapiens brain-specific protein ... 87 5e-17
AY072034-1|AAL62338.1| 170|Homo sapiens p25 beta protein. 87 5e-17
D87440-1|BAA13382.2| 702|Homo sapiens KIAA0252 protein. 34 0.48
BC015052-1|AAH15052.1| 585|Homo sapiens Rtf1, Paf1/RNA polymera... 34 0.48
M24355-1|AAA52454.1| 416|Homo sapiens FLG protein. 32 1.9
AL356504-1|CAI19595.1| 4061|Homo sapiens filaggrin protein. 32 1.9
AB208881-1|BAD92118.1| 583|Homo sapiens PREDICTED: filaggrin va... 32 1.9
M60499-1|AAA63246.1| 465|Homo sapiens profilaggrin protein. 30 7.8
AK126984-1|BAC86777.1| 136|Homo sapiens protein ( Homo sapiens ... 30 7.8
>BC037798-1|AAH37798.1| 176|Homo sapiens TPPP3 protein protein.
Length = 176
Score = 101 bits (242), Expect = 3e-21
Identities = 60/137 (43%), Positives = 83/137 (60%), Gaps = 9/137 (6%)
Frame = -2
Query: 431 GDPKSDGKAITLSQSDKWMKQAKVIDGKKITTTDTAIHFKKLKSVKLGIDDYQKF---LD 261
GDPK+ G+ + K K KV DGK +T TD I F K+K + +Y++F L+
Sbjct: 21 GDPKASGQEMNGKNWAKLCKDCKVADGKSVTGTDVDIVFSKVKGKSARVINYEEFKKALE 80
Query: 260 DLA------KNKKVELDEIKKKLTTCGQPGITSHVTKSPAAAAAVDRLTDTSKYTGSHRQ 99
+LA K+K+ D I + + G+ VTK+ A VDRLTDTS+YTGSH++
Sbjct: 81 ELATKRFKGKSKEEAFDAICQLVA--GKEPANVGVTKAKTGGA-VDRLTDTSRYTGSHKE 137
Query: 98 RFDETGKGKGIAGRKDL 48
RFDE+GKGKGIAGR+D+
Sbjct: 138 RFDESGKGKGIAGRQDI 154
>BC000691-1|AAH00691.1| 176|Homo sapiens brain specific protein
protein.
Length = 176
Score = 101 bits (242), Expect = 3e-21
Identities = 60/137 (43%), Positives = 83/137 (60%), Gaps = 9/137 (6%)
Frame = -2
Query: 431 GDPKSDGKAITLSQSDKWMKQAKVIDGKKITTTDTAIHFKKLKSVKLGIDDYQKF---LD 261
GDPK+ G+ + K K KV DGK +T TD I F K+K + +Y++F L+
Sbjct: 21 GDPKASGQEMNGKNWAKLCKDCKVADGKSVTGTDVDIVFSKVKGKSARVINYEEFKKALE 80
Query: 260 DLA------KNKKVELDEIKKKLTTCGQPGITSHVTKSPAAAAAVDRLTDTSKYTGSHRQ 99
+LA K+K+ D I + + G+ VTK+ A VDRLTDTS+YTGSH++
Sbjct: 81 ELATKRFKGKSKEEAFDAICQLVA--GKEPANVGVTKAKTGGA-VDRLTDTSRYTGSHKE 137
Query: 98 RFDETGKGKGIAGRKDL 48
RFDE+GKGKGIAGR+D+
Sbjct: 138 RFDESGKGKGIAGRQDI 154
>AF132972-1|AAD27747.1| 176|Homo sapiens CGI-38 protein protein.
Length = 176
Score = 101 bits (242), Expect = 3e-21
Identities = 60/137 (43%), Positives = 83/137 (60%), Gaps = 9/137 (6%)
Frame = -2
Query: 431 GDPKSDGKAITLSQSDKWMKQAKVIDGKKITTTDTAIHFKKLKSVKLGIDDYQKF---LD 261
GDPK+ G+ + K K KV DGK +T TD I F K+K + +Y++F L+
Sbjct: 21 GDPKASGQEMNGKNWAKLCKDCKVADGKSVTGTDVDIVFSKVKGKSARVINYEEFKKALE 80
Query: 260 DLA------KNKKVELDEIKKKLTTCGQPGITSHVTKSPAAAAAVDRLTDTSKYTGSHRQ 99
+LA K+K+ D I + + G+ VTK+ A VDRLTDTS+YTGSH++
Sbjct: 81 ELATKRFQGKSKEEAFDAICQLVA--GKEPANVGVTKAKTGGA-VDRLTDTSRYTGSHKE 137
Query: 98 RFDETGKGKGIAGRKDL 48
RFDE+GKGKGIAGR+D+
Sbjct: 138 RFDESGKGKGIAGRQDI 154
>BT020035-1|AAV38838.1| 219|Homo sapiens brain-specific protein p25
alpha protein.
Length = 219
Score = 91.1 bits (216), Expect = 4e-18
Identities = 59/162 (36%), Positives = 89/162 (54%), Gaps = 7/162 (4%)
Frame = -2
Query: 512 GASNGTSSKSEDNALXXXXXXXXXXXFGDPKSDGKAITLSQSDKWMKQAKVIDGKKITTT 333
GA G ++ E +AL GD ++ G+ + K K +VIDG+ +T T
Sbjct: 37 GAGEGAAASPELSALEEAFRRFAVH--GDARATGREMHGKNWSKLCKDCQVIDGRNVTVT 94
Query: 332 DTAIHFKKLKSVK---LGIDDYQKFLDDLAKN--KKVELDEIKKKLTTC--GQPGITSHV 174
D I F K+K + + +Q+ L++LAK K +E +++ G+ I S V
Sbjct: 95 DVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGKAPIISGV 154
Query: 173 TKSPAAAAAVDRLTDTSKYTGSHRQRFDETGKGKGIAGRKDL 48
TK+ ++ V RLTDT+K+TGSH++RFD +GKGKG AGR DL
Sbjct: 155 TKA-ISSPTVSRLTDTTKFTGSHKERFDPSGKGKGKAGRVDL 195
>BC131506-1|AAI31507.1| 219|Homo sapiens tubulin polymerization
promoting protein protein.
Length = 219
Score = 91.1 bits (216), Expect = 4e-18
Identities = 59/162 (36%), Positives = 89/162 (54%), Gaps = 7/162 (4%)
Frame = -2
Query: 512 GASNGTSSKSEDNALXXXXXXXXXXXFGDPKSDGKAITLSQSDKWMKQAKVIDGKKITTT 333
GA G ++ E +AL GD ++ G+ + K K +VIDG+ +T T
Sbjct: 37 GAGEGAAASPELSALEEAFRRFAVH--GDARATGREMHGKNWSKLCKDCQVIDGRNVTVT 94
Query: 332 DTAIHFKKLKSVK---LGIDDYQKFLDDLAKN--KKVELDEIKKKLTTC--GQPGITSHV 174
D I F K+K + + +Q+ L++LAK K +E +++ G+ I S V
Sbjct: 95 DVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGKAPIISGV 154
Query: 173 TKSPAAAAAVDRLTDTSKYTGSHRQRFDETGKGKGIAGRKDL 48
TK+ ++ V RLTDT+K+TGSH++RFD +GKGKG AGR DL
Sbjct: 155 TKA-ISSPTVSRLTDTTKFTGSHKERFDPSGKGKGKAGRVDL 195
>BC040496-1|AAH40496.1| 234|Homo sapiens TPPP protein protein.
Length = 234
Score = 91.1 bits (216), Expect = 4e-18
Identities = 59/162 (36%), Positives = 89/162 (54%), Gaps = 7/162 (4%)
Frame = -2
Query: 512 GASNGTSSKSEDNALXXXXXXXXXXXFGDPKSDGKAITLSQSDKWMKQAKVIDGKKITTT 333
GA G ++ E +AL GD ++ G+ + K K +VIDG+ +T T
Sbjct: 52 GAGEGAAASPELSALEEAFRRFAVH--GDARATGREMHGKNWSKLCKDCQVIDGRNVTVT 109
Query: 332 DTAIHFKKLKSVK---LGIDDYQKFLDDLAKN--KKVELDEIKKKLTTC--GQPGITSHV 174
D I F K+K + + +Q+ L++LAK K +E +++ G+ I S V
Sbjct: 110 DVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGKAPIISGV 169
Query: 173 TKSPAAAAAVDRLTDTSKYTGSHRQRFDETGKGKGIAGRKDL 48
TK+ ++ V RLTDT+K+TGSH++RFD +GKGKG AGR DL
Sbjct: 170 TKA-ISSPTVSRLTDTTKFTGSHKERFDPSGKGKGKAGRVDL 210
>AY319261-1|AAQ96657.1| 219|Homo sapiens fibroblast growth factor-2
repression protein-1 protein.
Length = 219
Score = 91.1 bits (216), Expect = 4e-18
Identities = 59/162 (36%), Positives = 89/162 (54%), Gaps = 7/162 (4%)
Frame = -2
Query: 512 GASNGTSSKSEDNALXXXXXXXXXXXFGDPKSDGKAITLSQSDKWMKQAKVIDGKKITTT 333
GA G ++ E +AL GD ++ G+ + K K +VIDG+ +T T
Sbjct: 37 GAGEGAAASPELSALEEAFRRFAVH--GDARATGREMHGKNWSKLCKDCQVIDGRNVTVT 94
Query: 332 DTAIHFKKLKSVK---LGIDDYQKFLDDLAKN--KKVELDEIKKKLTTC--GQPGITSHV 174
D I F K+K + + +Q+ L++LAK K +E +++ G+ I S V
Sbjct: 95 DVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGKAPIISGV 154
Query: 173 TKSPAAAAAVDRLTDTSKYTGSHRQRFDETGKGKGIAGRKDL 48
TK+ ++ V RLTDT+K+TGSH++RFD +GKGKG AGR DL
Sbjct: 155 TKA-ISSPTVSRLTDTTKFTGSHKERFDPSGKGKGKAGRVDL 195
>AB017016-1|BAA36164.1| 219|Homo sapiens p25 alpha protein.
Length = 219
Score = 91.1 bits (216), Expect = 4e-18
Identities = 59/162 (36%), Positives = 89/162 (54%), Gaps = 7/162 (4%)
Frame = -2
Query: 512 GASNGTSSKSEDNALXXXXXXXXXXXFGDPKSDGKAITLSQSDKWMKQAKVIDGKKITTT 333
GA G ++ E +AL GD ++ G+ + K K +VIDG+ +T T
Sbjct: 37 GAGEGAAASPELSALEEAFRRFAVH--GDARATGREMHGKNWSKLCKDCQVIDGRNVTVT 94
Query: 332 DTAIHFKKLKSVK---LGIDDYQKFLDDLAKN--KKVELDEIKKKLTTC--GQPGITSHV 174
D I F K+K + + +Q+ L++LAK K +E +++ G+ I S V
Sbjct: 95 DVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGKAPIISGV 154
Query: 173 TKSPAAAAAVDRLTDTSKYTGSHRQRFDETGKGKGIAGRKDL 48
TK+ ++ V RLTDT+K+TGSH++RFD +GKGKG AGR DL
Sbjct: 155 TKA-ISSPTVSRLTDTTKFTGSHKERFDPSGKGKGKAGRVDL 195
>BC038970-1|AAH38970.1| 170|Homo sapiens tubulin
polymerization-promoting protein family member 2
protein.
Length = 170
Score = 87.4 bits (207), Expect = 5e-17
Identities = 51/136 (37%), Positives = 78/136 (57%), Gaps = 7/136 (5%)
Frame = -2
Query: 431 GDPKSDGKAITLSQSDKWMKQAKVIDGKKITTTDTAIHFKKLKSVKLGIDDYQKFLD--- 261
G+ S G + K K ++DGK +T+TD I F K+K+ +Q+F +
Sbjct: 16 GESSSSGTEMNNKNFSKLCKDCGIMDGKTVTSTDVDIVFSKVKAKNARTITFQQFKEAVK 75
Query: 260 DLAKN--KKVELDEIKKKLTTC--GQPGITSHVTKSPAAAAAVDRLTDTSKYTGSHRQRF 93
+L + K DE+ + + G+ T+ TK+ AVDRLTDTSKYTG+H++ F
Sbjct: 76 ELGQKRFKGKSPDEVLENIYGLMEGKDPATTGATKA-TTVGAVDRLTDTSKYTGTHKELF 134
Query: 92 DETGKGKGIAGRKDLS 45
DE+GKGKGIAGR++++
Sbjct: 135 DESGKGKGIAGREEMT 150
>AY173946-1|AAO49716.1| 170|Homo sapiens brain-specific protein
p25-like protein protein.
Length = 170
Score = 87.4 bits (207), Expect = 5e-17
Identities = 51/136 (37%), Positives = 78/136 (57%), Gaps = 7/136 (5%)
Frame = -2
Query: 431 GDPKSDGKAITLSQSDKWMKQAKVIDGKKITTTDTAIHFKKLKSVKLGIDDYQKFLD--- 261
G+ S G + K K ++DGK +T+TD I F K+K+ +Q+F +
Sbjct: 16 GESSSSGTEMNNKNFSKLCKDCGIMDGKTVTSTDVDIVFSKVKAKNARTITFQQFKEAVK 75
Query: 260 DLAKN--KKVELDEIKKKLTTC--GQPGITSHVTKSPAAAAAVDRLTDTSKYTGSHRQRF 93
+L + K DE+ + + G+ T+ TK+ AVDRLTDTSKYTG+H++ F
Sbjct: 76 ELGQKRFKGKSPDEVLENIYGLMEGKDPATTGATKA-TTVGAVDRLTDTSKYTGTHKELF 134
Query: 92 DETGKGKGIAGRKDLS 45
DE+GKGKGIAGR++++
Sbjct: 135 DESGKGKGIAGREEMT 150
>AY072034-1|AAL62338.1| 170|Homo sapiens p25 beta protein.
Length = 170
Score = 87.4 bits (207), Expect = 5e-17
Identities = 51/136 (37%), Positives = 78/136 (57%), Gaps = 7/136 (5%)
Frame = -2
Query: 431 GDPKSDGKAITLSQSDKWMKQAKVIDGKKITTTDTAIHFKKLKSVKLGIDDYQKFLD--- 261
G+ S G + K K ++DGK +T+TD I F K+K+ +Q+F +
Sbjct: 16 GESSSSGTEMNNKNFSKLCKDCGIMDGKTVTSTDVDIVFSKVKAKNARTITFQQFKEAVK 75
Query: 260 DLAKN--KKVELDEIKKKLTTC--GQPGITSHVTKSPAAAAAVDRLTDTSKYTGSHRQRF 93
+L + K DE+ + + G+ T+ TK+ AVDRLTDTSKYTG+H++ F
Sbjct: 76 ELGQKRFKGKSPDEVLENIYGLMEGKDPATTGATKA-TTVGAVDRLTDTSKYTGTHKELF 134
Query: 92 DETGKGKGIAGRKDLS 45
DE+GKGKGIAGR++++
Sbjct: 135 DESGKGKGIAGREEMT 150
>D87440-1|BAA13382.2| 702|Homo sapiens KIAA0252 protein.
Length = 702
Score = 34.3 bits (75), Expect = 0.48
Identities = 33/141 (23%), Positives = 63/141 (44%)
Frame = -2
Query: 599 STEAQNTDAAVEQVTQEVKDVKLENGNAPGASNGTSSKSEDNALXXXXXXXXXXXFGDPK 420
S+ + + D++ E E +V + N+ +S+ + S SED GD +
Sbjct: 127 SSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLM---GDEE 183
Query: 419 SDGKAITLSQSDKWMKQAKVIDGKKITTTDTAIHFKKLKSVKLGIDDYQKFLDDLAKNKK 240
+ +++ ++ + I+ +++ I KKLK+ K +K + K KK
Sbjct: 184 DRARLEQMTEKEREQELFNRIEKREVLKRRFEIK-KKLKTAK------KK--EKKEKKKK 234
Query: 239 VELDEIKKKLTTCGQPGITSH 177
E ++ KKKLT + +TSH
Sbjct: 235 QEEEQEKKKLTQIQESQVTSH 255
>BC015052-1|AAH15052.1| 585|Homo sapiens Rtf1, Paf1/RNA polymerase
II complex component, homolog (S. cerevisiae) protein.
Length = 585
Score = 34.3 bits (75), Expect = 0.48
Identities = 33/141 (23%), Positives = 63/141 (44%)
Frame = -2
Query: 599 STEAQNTDAAVEQVTQEVKDVKLENGNAPGASNGTSSKSEDNALXXXXXXXXXXXFGDPK 420
S+ + + D++ E E +V + N+ +S+ + S SED GD +
Sbjct: 10 SSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHDGYGEDLM---GDEE 66
Query: 419 SDGKAITLSQSDKWMKQAKVIDGKKITTTDTAIHFKKLKSVKLGIDDYQKFLDDLAKNKK 240
+ +++ ++ + I+ +++ I KKLK+ K +K + K KK
Sbjct: 67 DRARLEQMTEKEREQELFNRIEKREVLKRRFEIK-KKLKTAK------KK--EKKEKKKK 117
Query: 239 VELDEIKKKLTTCGQPGITSH 177
E ++ KKKLT + +TSH
Sbjct: 118 QEEEQEKKKLTQIQESQVTSH 138
>M24355-1|AAA52454.1| 416|Homo sapiens FLG protein.
Length = 416
Score = 32.3 bits (70), Expect = 1.9
Identities = 13/42 (30%), Positives = 23/42 (54%)
Frame = -1
Query: 411 KSHHALAKRQMDEASQSH*WKENNNNGHGHSLQKTQIGKTRH 286
++HH A+ Q+ + S+ + + GHGHS ++ TRH
Sbjct: 201 RNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRH 242
>AL356504-1|CAI19595.1| 4061|Homo sapiens filaggrin protein.
Length = 4061
Score = 32.3 bits (70), Expect = 1.9
Identities = 13/42 (30%), Positives = 23/42 (54%)
Frame = -1
Query: 411 KSHHALAKRQMDEASQSH*WKENNNNGHGHSLQKTQIGKTRH 286
++HH A+ Q+ + S+ + + GHGHS ++ TRH
Sbjct: 2589 RNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRH 2630
Score = 32.3 bits (70), Expect = 1.9
Identities = 13/42 (30%), Positives = 23/42 (54%)
Frame = -1
Query: 411 KSHHALAKRQMDEASQSH*WKENNNNGHGHSLQKTQIGKTRH 286
++HH A+ Q+ + S+ + + GHGHS ++ TRH
Sbjct: 2913 RNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRH 2954
Score = 30.3 bits (65), Expect = 7.8
Identities = 13/42 (30%), Positives = 21/42 (50%)
Frame = -1
Query: 411 KSHHALAKRQMDEASQSH*WKENNNNGHGHSLQKTQIGKTRH 286
++HH A+ Q + S+ + GHGHS ++ TRH
Sbjct: 643 RNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSADSSRKSGTRH 684
>AB208881-1|BAD92118.1| 583|Homo sapiens PREDICTED: filaggrin
variant protein.
Length = 583
Score = 32.3 bits (70), Expect = 1.9
Identities = 13/42 (30%), Positives = 23/42 (54%)
Frame = -1
Query: 411 KSHHALAKRQMDEASQSH*WKENNNNGHGHSLQKTQIGKTRH 286
++HH A+ Q+ + S+ + + GHGHS ++ TRH
Sbjct: 105 RNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRH 146
Score = 32.3 bits (70), Expect = 1.9
Identities = 13/42 (30%), Positives = 23/42 (54%)
Frame = -1
Query: 411 KSHHALAKRQMDEASQSH*WKENNNNGHGHSLQKTQIGKTRH 286
++HH A+ Q+ + S+ + + GHGHS ++ TRH
Sbjct: 429 RNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRH 470
>M60499-1|AAA63246.1| 465|Homo sapiens profilaggrin protein.
Length = 465
Score = 30.3 bits (65), Expect = 7.8
Identities = 13/42 (30%), Positives = 21/42 (50%)
Frame = -1
Query: 411 KSHHALAKRQMDEASQSH*WKENNNNGHGHSLQKTQIGKTRH 286
++HH A+ Q + S+ + GHGHS ++ TRH
Sbjct: 421 RNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSADSSRQSGTRH 462
>AK126984-1|BAC86777.1| 136|Homo sapiens protein ( Homo sapiens
cDNA FLJ45038 fis, clone BRAWH3020200. ).
Length = 136
Score = 30.3 bits (65), Expect = 7.8
Identities = 20/58 (34%), Positives = 30/58 (51%)
Frame = +1
Query: 37 PARLRSFLPAIPFPFPVSSKRCLCEPVYLLVSVNRSTAAAAAGDFVTCDVIPGWPQVV 210
P+ L SF+P++ F +S + LC P + V + TAA+A+ VT P W V
Sbjct: 12 PSFLPSFIPSLSLSFFLSDRVLLCCPGWSAVVWSHLTAASASWVQVTS---PAWASQV 66
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 105,064,334
Number of Sequences: 237096
Number of extensions: 2153203
Number of successful extensions: 9431
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 9165
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 9420
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 9127122082
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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