Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= psV30308.Seq
(812 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Y14487-1|CAB54840.1| 347|Homo sapiens cytosolic serine hydroxym... 150 7e-36
Y14485-1|CAB54838.1| 483|Homo sapiens cytosolic serine hydroxym... 150 7e-36
L23928-3|AAA36019.1| 403|Homo sapiens serine hydroxymethyltrans... 150 7e-36
L23928-2|AAA36018.1| 444|Homo sapiens serine hydroxymethyltrans... 150 7e-36
L23928-1|AAA36020.1| 483|Homo sapiens serine hydroxymethyltrans... 150 7e-36
L11931-1|AAA63257.1| 483|Homo sapiens serine hydroxymethyltrans... 150 7e-36
BC038598-1|AAH38598.1| 483|Homo sapiens serine hydroxymethyltra... 150 7e-36
BC022874-1|AAH22874.1| 444|Homo sapiens serine hydroxymethyltra... 150 7e-36
BC007979-1|AAH07979.1| 483|Homo sapiens serine hydroxymethyltra... 150 7e-36
AK223552-1|BAD97272.1| 483|Homo sapiens serine hydroxymethyltra... 150 7e-36
BC091501-1|AAH91501.1| 480|Homo sapiens SHMT2 protein protein. 137 5e-32
U23143-1|AAA64572.1| 483|Homo sapiens mitochondrial serine hydr... 135 2e-31
L11932-1|AAA63258.1| 474|Homo sapiens serine hydroxymethyltrans... 135 2e-31
BT006866-1|AAP35512.1| 504|Homo sapiens serine hydroxymethyltra... 135 2e-31
BC044211-1|AAH44211.1| 504|Homo sapiens serine hydroxymethyltra... 135 2e-31
BC032584-1|AAH32584.1| 494|Homo sapiens SHMT2 protein protein. 135 2e-31
BC013677-1|AAH13677.1| 504|Homo sapiens serine hydroxymethyltra... 135 2e-31
BC011911-1|AAH11911.1| 504|Homo sapiens serine hydroxymethyltra... 135 2e-31
AK223555-1|BAD97275.1| 504|Homo sapiens serine hydroxymethyltra... 135 2e-31
Y14488-1|CAB54841.1| 129|Homo sapiens 14 kDa protein protein. 55 3e-07
Y14486-1|CAB54839.1| 310|Homo sapiens cytosolic serine hydroxym... 46 1e-04
AK055053-1|BAB70847.1| 135|Homo sapiens protein. 40 0.014
>Y14487-1|CAB54840.1| 347|Homo sapiens cytosolic serine
hydroxymethyltransferase protein.
Length = 347
Score = 150 bits (363), Expect = 7e-36
Identities = 66/84 (78%), Positives = 73/84 (86%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
QRYYGG E+IDE+E L Q R+L+AY+L + WGVNVQPYSGSPANFAVYT +VEPHGRIM
Sbjct: 80 QRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIM 139
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHGF T KKISAT
Sbjct: 140 GLDLPDGGHLTHGFMTDKKKISAT 163
Score = 75.8 bits (178), Expect = 2e-13
Identities = 37/70 (52%), Positives = 48/70 (68%)
Frame = +2
Query: 77 KLLNSNLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPI 256
K+L L ++D E+++II KE +RQR GLE+IASENF S VL+ L SCL+NKYSEG P
Sbjct: 20 KMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPG 79
Query: 257 NGTMGGMNIL 286
GG +
Sbjct: 80 QRYYGGTEFI 89
Score = 66.1 bits (154), Expect = 1e-10
Identities = 38/79 (48%), Positives = 51/79 (64%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYKV+P +G I+YD+L E A+LF P+LIIAG +++++ Y R+I
Sbjct: 165 IFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLE-YARLRKIADENGA 223
Query: 690 LNLMADXGSRYLGLVAGQV 746
LMAD + GLVA V
Sbjct: 224 Y-LMADM-AHISGLVAAGV 240
>Y14485-1|CAB54838.1| 483|Homo sapiens cytosolic serine
hydroxymethyltransferase protein.
Length = 483
Score = 150 bits (363), Expect = 7e-36
Identities = 66/84 (78%), Positives = 73/84 (86%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
QRYYGG E+IDE+E L Q R+L+AY+L + WGVNVQPYSGSPANFAVYT +VEPHGRIM
Sbjct: 80 QRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIM 139
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHGF T KKISAT
Sbjct: 140 GLDLPDGGHLTHGFMTDKKKISAT 163
Score = 75.8 bits (178), Expect = 2e-13
Identities = 37/70 (52%), Positives = 48/70 (68%)
Frame = +2
Query: 77 KLLNSNLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPI 256
K+L L ++D E+++II KE +RQR GLE+IASENF S VL+ L SCL+NKYSEG P
Sbjct: 20 KMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPG 79
Query: 257 NGTMGGMNIL 286
GG +
Sbjct: 80 QRYYGGTEFI 89
Score = 66.1 bits (154), Expect = 1e-10
Identities = 38/79 (48%), Positives = 51/79 (64%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYKV+P +G I+YD+L E A+LF P+LIIAG +++++ Y R+I
Sbjct: 165 IFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLE-YARLRKIADENGA 223
Query: 690 LNLMADXGSRYLGLVAGQV 746
LMAD + GLVA V
Sbjct: 224 Y-LMADM-AHISGLVAAGV 240
>L23928-3|AAA36019.1| 403|Homo sapiens serine
hydroxymethyltransferase protein.
Length = 403
Score = 150 bits (363), Expect = 7e-36
Identities = 66/84 (78%), Positives = 73/84 (86%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
QRYYGG E+IDE+E L Q R+L+AY+L + WGVNVQPYSGSPANFAVYT +VEPHGRIM
Sbjct: 80 QRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIM 139
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHGF T KKISAT
Sbjct: 140 GLDLPDGGHLTHGFMTDKKKISAT 163
Score = 75.8 bits (178), Expect = 2e-13
Identities = 37/70 (52%), Positives = 48/70 (68%)
Frame = +2
Query: 77 KLLNSNLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPI 256
K+L L ++D E+++II KE +RQR GLE+IASENF S VL+ L SCL+NKYSEG P
Sbjct: 20 KMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPG 79
Query: 257 NGTMGGMNIL 286
GG +
Sbjct: 80 QRYYGGTEFI 89
Score = 66.1 bits (154), Expect = 1e-10
Identities = 38/79 (48%), Positives = 51/79 (64%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYKV+P +G I+YD+L E A+LF P+LIIAG +++++ Y R+I
Sbjct: 165 IFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLE-YARLRKIADENGA 223
Query: 690 LNLMADXGSRYLGLVAGQV 746
LMAD + GLVA V
Sbjct: 224 Y-LMADM-AHISGLVAAGV 240
>L23928-2|AAA36018.1| 444|Homo sapiens serine
hydroxymethyltransferase protein.
Length = 444
Score = 150 bits (363), Expect = 7e-36
Identities = 66/84 (78%), Positives = 73/84 (86%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
QRYYGG E+IDE+E L Q R+L+AY+L + WGVNVQPYSGSPANFAVYT +VEPHGRIM
Sbjct: 80 QRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIM 139
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHGF T KKISAT
Sbjct: 140 GLDLPDGGHLTHGFMTDKKKISAT 163
Score = 75.8 bits (178), Expect = 2e-13
Identities = 37/70 (52%), Positives = 48/70 (68%)
Frame = +2
Query: 77 KLLNSNLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPI 256
K+L L ++D E+++II KE +RQR GLE+IASENF S VL+ L SCL+NKYSEG P
Sbjct: 20 KMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPG 79
Query: 257 NGTMGGMNIL 286
GG +
Sbjct: 80 QRYYGGTEFI 89
Score = 66.1 bits (154), Expect = 1e-10
Identities = 38/79 (48%), Positives = 51/79 (64%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYKV+P +G I+YD+L E A+LF P+LIIAG +++++ Y R+I
Sbjct: 165 IFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLE-YARLRKIADENGA 223
Query: 690 LNLMADXGSRYLGLVAGQV 746
LMAD + GLVA V
Sbjct: 224 Y-LMADM-AHISGLVAAGV 240
>L23928-1|AAA36020.1| 483|Homo sapiens serine
hydroxymethyltransferase protein.
Length = 483
Score = 150 bits (363), Expect = 7e-36
Identities = 66/84 (78%), Positives = 73/84 (86%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
QRYYGG E+IDE+E L Q R+L+AY+L + WGVNVQPYSGSPANFAVYT +VEPHGRIM
Sbjct: 80 QRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIM 139
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHGF T KKISAT
Sbjct: 140 GLDLPDGGHLTHGFMTDKKKISAT 163
Score = 75.8 bits (178), Expect = 2e-13
Identities = 37/70 (52%), Positives = 48/70 (68%)
Frame = +2
Query: 77 KLLNSNLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPI 256
K+L L ++D E+++II KE +RQR GLE+IASENF S VL+ L SCL+NKYSEG P
Sbjct: 20 KMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPG 79
Query: 257 NGTMGGMNIL 286
GG +
Sbjct: 80 QRYYGGTEFI 89
Score = 66.1 bits (154), Expect = 1e-10
Identities = 38/79 (48%), Positives = 51/79 (64%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYKV+P +G I+YD+L E A+LF P+LIIAG +++++ Y R+I
Sbjct: 165 IFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLE-YARLRKIADENGA 223
Query: 690 LNLMADXGSRYLGLVAGQV 746
LMAD + GLVA V
Sbjct: 224 Y-LMADM-AHISGLVAAGV 240
>L11931-1|AAA63257.1| 483|Homo sapiens serine
hydroxymethyltransferase protein.
Length = 483
Score = 150 bits (363), Expect = 7e-36
Identities = 66/84 (78%), Positives = 73/84 (86%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
QRYYGG E+IDE+E L Q R+L+AY+L + WGVNVQPYSGSPANFAVYT +VEPHGRIM
Sbjct: 80 QRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIM 139
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHGF T KKISAT
Sbjct: 140 GLDLPDGGHLTHGFMTDKKKISAT 163
Score = 75.8 bits (178), Expect = 2e-13
Identities = 37/70 (52%), Positives = 48/70 (68%)
Frame = +2
Query: 77 KLLNSNLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPI 256
K+L L ++D E+++II KE +RQR GLE+IASENF S VL+ L SCL+NKYSEG P
Sbjct: 20 KMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPG 79
Query: 257 NGTMGGMNIL 286
GG +
Sbjct: 80 QRYYGGTEFI 89
Score = 66.1 bits (154), Expect = 1e-10
Identities = 38/79 (48%), Positives = 51/79 (64%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYKV+P +G I+YD+L E A+LF P+LIIAG +++++ Y R+I
Sbjct: 165 IFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLE-YARLRKIADENGA 223
Query: 690 LNLMADXGSRYLGLVAGQV 746
LMAD + GLVA V
Sbjct: 224 Y-LMADM-AHISGLVAAGV 240
>BC038598-1|AAH38598.1| 483|Homo sapiens serine
hydroxymethyltransferase 1 (soluble) protein.
Length = 483
Score = 150 bits (363), Expect = 7e-36
Identities = 66/84 (78%), Positives = 73/84 (86%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
QRYYGG E+IDE+E L Q R+L+AY+L + WGVNVQPYSGSPANFAVYT +VEPHGRIM
Sbjct: 80 QRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIM 139
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHGF T KKISAT
Sbjct: 140 GLDLPDGGHLTHGFMTDKKKISAT 163
Score = 75.8 bits (178), Expect = 2e-13
Identities = 37/70 (52%), Positives = 48/70 (68%)
Frame = +2
Query: 77 KLLNSNLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPI 256
K+L L ++D E+++II KE +RQR GLE+IASENF S VL+ L SCL+NKYSEG P
Sbjct: 20 KMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPG 79
Query: 257 NGTMGGMNIL 286
GG +
Sbjct: 80 QRYYGGTEFI 89
Score = 66.1 bits (154), Expect = 1e-10
Identities = 38/79 (48%), Positives = 51/79 (64%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYKV+P +G I+YD+L E A+LF P+LIIAG +++++ Y R+I
Sbjct: 165 IFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLE-YARLRKIADENGA 223
Query: 690 LNLMADXGSRYLGLVAGQV 746
LMAD + GLVA V
Sbjct: 224 Y-LMADM-AHISGLVAAGV 240
>BC022874-1|AAH22874.1| 444|Homo sapiens serine
hydroxymethyltransferase 1 (soluble) protein.
Length = 444
Score = 150 bits (363), Expect = 7e-36
Identities = 66/84 (78%), Positives = 73/84 (86%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
QRYYGG E+IDE+E L Q R+L+AY+L + WGVNVQPYSGSPANFAVYT +VEPHGRIM
Sbjct: 80 QRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIM 139
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHGF T KKISAT
Sbjct: 140 GLDLPDGGHLTHGFMTDKKKISAT 163
Score = 75.8 bits (178), Expect = 2e-13
Identities = 37/70 (52%), Positives = 48/70 (68%)
Frame = +2
Query: 77 KLLNSNLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPI 256
K+L L ++D E+++II KE +RQR GLE+IASENF S VL+ L SCL+NKYSEG P
Sbjct: 20 KMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPG 79
Query: 257 NGTMGGMNIL 286
GG +
Sbjct: 80 QRYYGGTEFI 89
Score = 66.1 bits (154), Expect = 1e-10
Identities = 38/79 (48%), Positives = 51/79 (64%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYKV+P +G I+YD+L E A+LF P+LIIAG +++++ Y R+I
Sbjct: 165 IFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLE-YARLRKIADENGA 223
Query: 690 LNLMADXGSRYLGLVAGQV 746
LMAD + GLVA V
Sbjct: 224 Y-LMADM-AHISGLVAAGV 240
>BC007979-1|AAH07979.1| 483|Homo sapiens serine
hydroxymethyltransferase 1 (soluble) protein.
Length = 483
Score = 150 bits (363), Expect = 7e-36
Identities = 66/84 (78%), Positives = 73/84 (86%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
QRYYGG E+IDE+E L Q R+L+AY+L + WGVNVQPYSGSPANFAVYT +VEPHGRIM
Sbjct: 80 QRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIM 139
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHGF T KKISAT
Sbjct: 140 GLDLPDGGHLTHGFMTDKKKISAT 163
Score = 75.8 bits (178), Expect = 2e-13
Identities = 37/70 (52%), Positives = 48/70 (68%)
Frame = +2
Query: 77 KLLNSNLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPI 256
K+L L ++D E+++II KE +RQR GLE+IASENF S VL+ L SCL+NKYSEG P
Sbjct: 20 KMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPG 79
Query: 257 NGTMGGMNIL 286
GG +
Sbjct: 80 QRYYGGTEFI 89
Score = 66.1 bits (154), Expect = 1e-10
Identities = 38/79 (48%), Positives = 51/79 (64%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYKV+P +G I+YD+L E A+LF P+LIIAG +++++ Y R+I
Sbjct: 165 IFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLE-YARLRKIADENGA 223
Query: 690 LNLMADXGSRYLGLVAGQV 746
LMAD + GLVA V
Sbjct: 224 Y-LMADM-AHISGLVAAGV 240
>AK223552-1|BAD97272.1| 483|Homo sapiens serine
hydroxymethyltransferase 1 (soluble) isoform 1 variant
protein.
Length = 483
Score = 150 bits (363), Expect = 7e-36
Identities = 66/84 (78%), Positives = 73/84 (86%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
QRYYGG E+IDE+E L Q R+L+AY+L + WGVNVQPYSGSPANFAVYT +VEPHGRIM
Sbjct: 80 QRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIM 139
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHGF T KKISAT
Sbjct: 140 GLDLPDGGHLTHGFMTDKKKISAT 163
Score = 75.8 bits (178), Expect = 2e-13
Identities = 37/70 (52%), Positives = 48/70 (68%)
Frame = +2
Query: 77 KLLNSNLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPI 256
K+L L ++D E+++II KE +RQR GLE+IASENF S VL+ L SCL+NKYSEG P
Sbjct: 20 KMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPG 79
Query: 257 NGTMGGMNIL 286
GG +
Sbjct: 80 QRYYGGTEFI 89
Score = 66.1 bits (154), Expect = 1e-10
Identities = 38/79 (48%), Positives = 51/79 (64%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYKV+P +G I+YD+L E A+LF P+LIIAG +++++ Y R+I
Sbjct: 165 IFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLE-YARLRKIADENGA 223
Query: 690 LNLMADXGSRYLGLVAGQV 746
LMAD + GLVA V
Sbjct: 224 Y-LMADM-AHISGLVAAGV 240
>BC091501-1|AAH91501.1| 480|Homo sapiens SHMT2 protein protein.
Length = 480
Score = 137 bits (331), Expect = 5e-32
Identities = 59/84 (70%), Positives = 70/84 (83%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
QRYYGG E +DEIE+L Q R+LEA+ L +WGVNVQPYSGSPAN AVYT +++PH RIM
Sbjct: 79 QRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIM 138
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHG+ + K+ISAT
Sbjct: 139 GLDLPDGGHLTHGYMSDVKRISAT 162
Score = 73.3 bits (172), Expect = 9e-13
Identities = 40/79 (50%), Positives = 57/79 (72%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYK++PK+GLIDY++LA TA+LF+PRLIIAG + + + Y RE+ + +
Sbjct: 164 IFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLID-YARMREV-CDEVK 221
Query: 690 LNLMADXGSRYLGLVAGQV 746
+L+AD + GLVA +V
Sbjct: 222 AHLLADM-AHISGLVAAKV 239
>U23143-1|AAA64572.1| 483|Homo sapiens mitochondrial serine
hydroxymethyltransferase protein.
Length = 483
Score = 135 bits (327), Expect = 2e-31
Identities = 58/84 (69%), Positives = 70/84 (83%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
+RYYGG E +DEIE+L Q R+LEA+ L +WGVNVQPYSGSPAN AVYT +++PH RIM
Sbjct: 82 KRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIM 141
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHG+ + K+ISAT
Sbjct: 142 GLDLPDGGHLTHGYMSDVKRISAT 165
Score = 73.3 bits (172), Expect = 9e-13
Identities = 33/65 (50%), Positives = 47/65 (72%)
Frame = +2
Query: 92 NLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPINGTMG 271
+L ++DPE+++++ +EKDRQ GLE+IASENF S L+ L SCL+NKYSEG P G
Sbjct: 27 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 86
Query: 272 GMNIL 286
G ++
Sbjct: 87 GAEVV 91
Score = 73.3 bits (172), Expect = 9e-13
Identities = 40/79 (50%), Positives = 57/79 (72%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYK++PK+GLIDY++LA TA+LF+PRLIIAG + + + Y RE+ + +
Sbjct: 167 IFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLID-YARMREV-CDEVK 224
Query: 690 LNLMADXGSRYLGLVAGQV 746
+L+AD + GLVA +V
Sbjct: 225 AHLLADM-AHISGLVAAKV 242
>L11932-1|AAA63258.1| 474|Homo sapiens serine
hydroxymethyltransferase protein.
Length = 474
Score = 135 bits (327), Expect = 2e-31
Identities = 58/84 (69%), Positives = 70/84 (83%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
+RYYGG E +DEIE+L Q R+LEA+ L +WGVNVQPYSGSPAN AVYT +++PH RIM
Sbjct: 73 KRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIM 132
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHG+ + K+ISAT
Sbjct: 133 GLDLPDGGHLTHGYMSDVKRISAT 156
Score = 73.3 bits (172), Expect = 9e-13
Identities = 33/65 (50%), Positives = 47/65 (72%)
Frame = +2
Query: 92 NLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPINGTMG 271
+L ++DPE+++++ +EKDRQ GLE+IASENF S L+ L SCL+NKYSEG P G
Sbjct: 18 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 77
Query: 272 GMNIL 286
G ++
Sbjct: 78 GAEVV 82
Score = 73.3 bits (172), Expect = 9e-13
Identities = 40/79 (50%), Positives = 57/79 (72%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYK++PK+GLIDY++LA TA+LF+PRLIIAG + + + Y RE+ + +
Sbjct: 158 IFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLID-YARMREV-CDEVK 215
Query: 690 LNLMADXGSRYLGLVAGQV 746
+L+AD + GLVA +V
Sbjct: 216 AHLLADM-AHISGLVAAKV 233
>BT006866-1|AAP35512.1| 504|Homo sapiens serine
hydroxymethyltransferase 2 (mitochondrial) protein.
Length = 504
Score = 135 bits (327), Expect = 2e-31
Identities = 58/84 (69%), Positives = 70/84 (83%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
+RYYGG E +DEIE+L Q R+LEA+ L +WGVNVQPYSGSPAN AVYT +++PH RIM
Sbjct: 103 KRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIM 162
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHG+ + K+ISAT
Sbjct: 163 GLDLPDGGHLTHGYMSDVKRISAT 186
Score = 73.3 bits (172), Expect = 9e-13
Identities = 33/65 (50%), Positives = 47/65 (72%)
Frame = +2
Query: 92 NLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPINGTMG 271
+L ++DPE+++++ +EKDRQ GLE+IASENF S L+ L SCL+NKYSEG P G
Sbjct: 48 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 107
Query: 272 GMNIL 286
G ++
Sbjct: 108 GAEVV 112
Score = 73.3 bits (172), Expect = 9e-13
Identities = 40/79 (50%), Positives = 57/79 (72%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYK++PK+GLIDY++LA TA+LF+PRLIIAG + + + Y RE+ + +
Sbjct: 188 IFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLID-YARMREV-CDEVK 245
Query: 690 LNLMADXGSRYLGLVAGQV 746
+L+AD + GLVA +V
Sbjct: 246 AHLLADM-AHISGLVAAKV 263
>BC044211-1|AAH44211.1| 504|Homo sapiens serine
hydroxymethyltransferase 2 (mitochondrial) protein.
Length = 504
Score = 135 bits (327), Expect = 2e-31
Identities = 58/84 (69%), Positives = 70/84 (83%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
+RYYGG E +DEIE+L Q R+LEA+ L +WGVNVQPYSGSPAN AVYT +++PH RIM
Sbjct: 103 KRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIM 162
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHG+ + K+ISAT
Sbjct: 163 GLDLPDGGHLTHGYMSDVKRISAT 186
Score = 73.3 bits (172), Expect = 9e-13
Identities = 33/65 (50%), Positives = 47/65 (72%)
Frame = +2
Query: 92 NLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPINGTMG 271
+L ++DPE+++++ +EKDRQ GLE+IASENF S L+ L SCL+NKYSEG P G
Sbjct: 48 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 107
Query: 272 GMNIL 286
G ++
Sbjct: 108 GAEVV 112
Score = 73.3 bits (172), Expect = 9e-13
Identities = 40/79 (50%), Positives = 57/79 (72%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYK++PK+GLIDY++LA TA+LF+PRLIIAG + + + Y RE+ + +
Sbjct: 188 IFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLID-YARMREV-CDEVK 245
Query: 690 LNLMADXGSRYLGLVAGQV 746
+L+AD + GLVA +V
Sbjct: 246 AHLLADM-AHISGLVAAKV 263
>BC032584-1|AAH32584.1| 494|Homo sapiens SHMT2 protein protein.
Length = 494
Score = 135 bits (327), Expect = 2e-31
Identities = 58/84 (69%), Positives = 70/84 (83%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
+RYYGG E +DEIE+L Q R+LEA+ L +WGVNVQPYSGSPAN AVYT +++PH RIM
Sbjct: 103 KRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIM 162
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHG+ + K+ISAT
Sbjct: 163 GLDLPDGGHLTHGYMSDVKRISAT 186
Score = 73.3 bits (172), Expect = 9e-13
Identities = 33/65 (50%), Positives = 47/65 (72%)
Frame = +2
Query: 92 NLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPINGTMG 271
+L ++DPE+++++ +EKDRQ GLE+IASENF S L+ L SCL+NKYSEG P G
Sbjct: 48 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 107
Query: 272 GMNIL 286
G ++
Sbjct: 108 GAEVV 112
Score = 44.8 bits (101), Expect = 4e-04
Identities = 33/79 (41%), Positives = 47/79 (59%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYK++ LA TA+LF+PRLIIAG + + + Y RE+ + +
Sbjct: 188 IFFESMPYKLN----------LALTARLFRPRLIIAGTSAYARLID-YARMREV-CDEVK 235
Query: 690 LNLMADXGSRYLGLVAGQV 746
+L+AD + GLVA +V
Sbjct: 236 AHLLADM-AHISGLVAAKV 253
>BC013677-1|AAH13677.1| 504|Homo sapiens serine
hydroxymethyltransferase 2 (mitochondrial) protein.
Length = 504
Score = 135 bits (327), Expect = 2e-31
Identities = 58/84 (69%), Positives = 70/84 (83%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
+RYYGG E +DEIE+L Q R+LEA+ L +WGVNVQPYSGSPAN AVYT +++PH RIM
Sbjct: 103 KRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIM 162
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHG+ + K+ISAT
Sbjct: 163 GLDLPDGGHLTHGYMSDVKRISAT 186
Score = 73.3 bits (172), Expect = 9e-13
Identities = 33/65 (50%), Positives = 47/65 (72%)
Frame = +2
Query: 92 NLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPINGTMG 271
+L ++DPE+++++ +EKDRQ GLE+IASENF S L+ L SCL+NKYSEG P G
Sbjct: 48 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 107
Query: 272 GMNIL 286
G ++
Sbjct: 108 GAEVV 112
Score = 73.3 bits (172), Expect = 9e-13
Identities = 40/79 (50%), Positives = 57/79 (72%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYK++PK+GLIDY++LA TA+LF+PRLIIAG + + + Y RE+ + +
Sbjct: 188 IFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLID-YARMREV-CDEVK 245
Query: 690 LNLMADXGSRYLGLVAGQV 746
+L+AD + GLVA +V
Sbjct: 246 AHLLADM-AHISGLVAAKV 263
>BC011911-1|AAH11911.1| 504|Homo sapiens serine
hydroxymethyltransferase 2 (mitochondrial) protein.
Length = 504
Score = 135 bits (327), Expect = 2e-31
Identities = 58/84 (69%), Positives = 70/84 (83%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
+RYYGG E +DEIE+L Q R+LEA+ L +WGVNVQPYSGSPAN AVYT +++PH RIM
Sbjct: 103 KRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIM 162
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHG+ + K+ISAT
Sbjct: 163 GLDLPDGGHLTHGYMSDVKRISAT 186
Score = 73.3 bits (172), Expect = 9e-13
Identities = 33/65 (50%), Positives = 47/65 (72%)
Frame = +2
Query: 92 NLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPINGTMG 271
+L ++DPE+++++ +EKDRQ GLE+IASENF S L+ L SCL+NKYSEG P G
Sbjct: 48 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 107
Query: 272 GMNIL 286
G ++
Sbjct: 108 GAEVV 112
Score = 73.3 bits (172), Expect = 9e-13
Identities = 40/79 (50%), Positives = 57/79 (72%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYK++PK+GLIDY++LA TA+LF+PRLIIAG + + + Y RE+ + +
Sbjct: 188 IFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLID-YARMREV-CDEVK 245
Query: 690 LNLMADXGSRYLGLVAGQV 746
+L+AD + GLVA +V
Sbjct: 246 AHLLADM-AHISGLVAAKV 263
>AK223555-1|BAD97275.1| 504|Homo sapiens serine
hydroxymethyltransferase 2 (mitochondrial) variant
protein.
Length = 504
Score = 135 bits (327), Expect = 2e-31
Identities = 58/84 (69%), Positives = 70/84 (83%)
Frame = +1
Query: 256 QRYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQPYSGSPANFAVYTGIVEPHGRIM 435
+RYYGG E +DEIE+L Q R+LEA+ L +WGVNVQPYSGSPAN AVYT +++PH RIM
Sbjct: 103 KRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIM 162
Query: 436 GLDLPDGGHLTHGFFTATKKISAT 507
GLDLPDGGHLTHG+ + K+ISAT
Sbjct: 163 GLDLPDGGHLTHGYMSDVKRISAT 186
Score = 73.3 bits (172), Expect = 9e-13
Identities = 33/65 (50%), Positives = 47/65 (72%)
Frame = +2
Query: 92 NLWEADPELFDIIVKEKDRQRAGLEMIASENFTSVPVLQCLSSCLHNKYSEGMPINGTMG 271
+L ++DPE+++++ +EKDRQ GLE+IASENF S L+ L SCL+NKYSEG P G
Sbjct: 48 SLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYG 107
Query: 272 GMNIL 286
G ++
Sbjct: 108 GAEVV 112
Score = 73.3 bits (172), Expect = 9e-13
Identities = 40/79 (50%), Positives = 57/79 (72%)
Frame = +3
Query: 510 IFFESMPYKVDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXE 689
IFFESMPYK++PK+GLIDY++LA TA+LF+PRLIIAG + + + Y RE+ + +
Sbjct: 188 IFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLID-YARMREV-CDEVK 245
Query: 690 LNLMADXGSRYLGLVAGQV 746
+L+AD + GLVA +V
Sbjct: 246 AHLLADM-AHISGLVAAKV 263
>Y14488-1|CAB54841.1| 129|Homo sapiens 14 kDa protein protein.
Length = 129
Score = 55.2 bits (127), Expect = 3e-07
Identities = 22/37 (59%), Positives = 29/37 (78%)
Frame = +1
Query: 259 RYYGGNEYIDEIEILAQNRSLEAYRLKSEEWGVNVQP 369
RYYGG E+IDE+E L Q R+L+AY+L + WGV+V P
Sbjct: 65 RYYGGTEFIDELETLCQKRALQAYKLDPQCWGVDVHP 101
>Y14486-1|CAB54839.1| 310|Homo sapiens cytosolic serine
hydroxymethyltransferase protein.
Length = 310
Score = 46.4 bits (105), Expect = 1e-04
Identities = 29/70 (41%), Positives = 42/70 (60%)
Frame = +3
Query: 537 VDPKSGLIDYDKLAETAKLFKPRLIIAGHELFTQDVSIYKXXREIRRRQXELNLMADXGS 716
V+P +G I+YD+L E A+LF P+LIIAG +++++ Y R+I LMAD +
Sbjct: 1 VNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLE-YARLRKIADENGAY-LMADM-A 57
Query: 717 RYLGLVAGQV 746
GLVA V
Sbjct: 58 HISGLVAAGV 67
>AK055053-1|BAB70847.1| 135|Homo sapiens protein.
Length = 135
Score = 39.5 bits (88), Expect = 0.014
Identities = 16/30 (53%), Positives = 26/30 (86%)
Frame = +2
Query: 92 NLWEADPELFDIIVKEKDRQRAGLEMIASE 181
+L ++DPE+++++ +EKDRQ GLE+IASE
Sbjct: 48 SLSDSDPEMWELLQREKDRQCRGLELIASE 77
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 116,525,862
Number of Sequences: 237096
Number of extensions: 2543328
Number of successful extensions: 4619
Number of sequences better than 10.0: 22
Number of HSP's better than 10.0 without gapping: 4339
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4618
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 10092110758
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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