Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= pg--0689.Seq
(772 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenas... 172 1e-42
CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein. 172 1e-42
CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein. 172 1e-42
BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein pr... 172 1e-42
BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenas... 172 1e-42
BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein. 172 1e-42
AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitr... 172 1e-42
AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitra... 172 1e-42
AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein. 172 1e-42
CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein. 170 4e-42
X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase... 162 1e-39
BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenas... 162 1e-39
BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenas... 162 1e-39
AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenas... 162 1e-39
U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase ... 159 8e-39
U62389-1|AAB17375.1| 154|Homo sapiens putative cytosolic NADP-d... 114 3e-25
>DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenase 1
protein.
Length = 371
Score = 172 bits (418), Expect = 1e-42
Identities = 76/86 (88%), Positives = 83/86 (96%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
K++NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW
Sbjct: 36 KKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGW 95
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAG 507
KPIIIGRHA+ DQY+ATDFVVPG G
Sbjct: 96 VKPIIIGRHAYGDQYRATDFVVPGPG 121
Score = 114 bits (275), Expect = 3e-25
Identities = 52/87 (59%), Positives = 69/87 (79%), Gaps = 2/87 (2%)
Frame = +3
Query: 510 LEIIFKPESG-EAIKHVVHEYK-GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLST 683
+EI + P G + + ++VH ++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLST
Sbjct: 123 VEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLST 182
Query: 684 KNTILKKYDGRFKDIFQDIYDREYKKR 764
KNTILKKYDGRFKDIFQ+IYD++YK +
Sbjct: 183 KNTILKKYDGRFKDIFQEIYDKQYKSQ 209
Score = 54.0 bits (124), Expect = 6e-07
Identities = 23/36 (63%), Positives = 31/36 (86%)
Frame = +2
Query: 146 LILPFLDIELNVYDLGMENRDKTDDQVTIDCAEAIK 253
LI P+++++L+ YDLG+ENRD T+DQVT D AEAIK
Sbjct: 1 LIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIK 36
>CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 172 bits (418), Expect = 1e-42
Identities = 76/86 (88%), Positives = 83/86 (96%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
K++NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW
Sbjct: 65 KKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGW 124
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAG 507
KPIIIGRHA+ DQY+ATDFVVPG G
Sbjct: 125 VKPIIIGRHAYGDQYRATDFVVPGPG 150
Score = 114 bits (275), Expect = 3e-25
Identities = 52/87 (59%), Positives = 69/87 (79%), Gaps = 2/87 (2%)
Frame = +3
Query: 510 LEIIFKPESG-EAIKHVVHEYK-GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLST 683
+EI + P G + + ++VH ++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLST
Sbjct: 152 VEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLST 211
Query: 684 KNTILKKYDGRFKDIFQDIYDREYKKR 764
KNTILKKYDGRFKDIFQ+IYD++YK +
Sbjct: 212 KNTILKKYDGRFKDIFQEIYDKQYKSQ 238
Score = 93.9 bits (223), Expect = 6e-19
Identities = 42/62 (67%), Positives = 53/62 (85%)
Frame = +2
Query: 68 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELNVYDLGMENRDKTDDQVTIDCAEA 247
KI G VV++ GDEMTRIIW+LIKEKLI P+++++L+ YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 248 IK 253
IK
Sbjct: 64 IK 65
>CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 172 bits (418), Expect = 1e-42
Identities = 76/86 (88%), Positives = 83/86 (96%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
K++NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW
Sbjct: 65 KKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGW 124
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAG 507
KPIIIGRHA+ DQY+ATDFVVPG G
Sbjct: 125 VKPIIIGRHAYGDQYRATDFVVPGPG 150
Score = 113 bits (272), Expect = 7e-25
Identities = 51/87 (58%), Positives = 69/87 (79%), Gaps = 2/87 (2%)
Frame = +3
Query: 510 LEIIFKPESG-EAIKHVVHEYK-GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLST 683
+E+ + P G + + ++VH ++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLST
Sbjct: 152 VEMTYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLST 211
Query: 684 KNTILKKYDGRFKDIFQDIYDREYKKR 764
KNTILKKYDGRFKDIFQ+IYD++YK +
Sbjct: 212 KNTILKKYDGRFKDIFQEIYDKQYKSQ 238
Score = 93.9 bits (223), Expect = 6e-19
Identities = 42/62 (67%), Positives = 53/62 (85%)
Frame = +2
Query: 68 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELNVYDLGMENRDKTDDQVTIDCAEA 247
KI G VV++ GDEMTRIIW+LIKEKLI P+++++L+ YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 248 IK 253
IK
Sbjct: 64 IK 65
>BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein
protein.
Length = 414
Score = 172 bits (418), Expect = 1e-42
Identities = 76/86 (88%), Positives = 83/86 (96%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
K++NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW
Sbjct: 65 KKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGW 124
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAG 507
KPIIIGRHA+ DQY+ATDFVVPG G
Sbjct: 125 VKPIIIGRHAYGDQYRATDFVVPGPG 150
Score = 112 bits (270), Expect = 1e-24
Identities = 52/87 (59%), Positives = 68/87 (78%), Gaps = 2/87 (2%)
Frame = +3
Query: 510 LEIIFKPESG-EAIKHVVHEYKGAG-VALAMFNTDASIIDFAHSSFKFALDRKYPLYLST 683
+EI + P G + + ++VH +G G VA+ M+N D SI DFAHSSF+ AL + +PLYLST
Sbjct: 152 VEITYTPSDGTQKVTYLVHNSEGGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLST 211
Query: 684 KNTILKKYDGRFKDIFQDIYDREYKKR 764
KNTILKKYDGRFKDIFQ+IYD++YK +
Sbjct: 212 KNTILKKYDGRFKDIFQEIYDKQYKSQ 238
Score = 93.9 bits (223), Expect = 6e-19
Identities = 42/62 (67%), Positives = 53/62 (85%)
Frame = +2
Query: 68 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELNVYDLGMENRDKTDDQVTIDCAEA 247
KI G VV++ GDEMTRIIW+LIKEKLI P+++++L+ YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 248 IK 253
IK
Sbjct: 64 IK 65
>BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenase 1
(NADP+), soluble protein.
Length = 414
Score = 172 bits (418), Expect = 1e-42
Identities = 76/86 (88%), Positives = 83/86 (96%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
K++NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW
Sbjct: 65 KKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGW 124
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAG 507
KPIIIGRHA+ DQY+ATDFVVPG G
Sbjct: 125 VKPIIIGRHAYGDQYRATDFVVPGPG 150
Score = 114 bits (275), Expect = 3e-25
Identities = 52/87 (59%), Positives = 69/87 (79%), Gaps = 2/87 (2%)
Frame = +3
Query: 510 LEIIFKPESG-EAIKHVVHEYK-GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLST 683
+EI + P G + + ++VH ++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLST
Sbjct: 152 VEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLST 211
Query: 684 KNTILKKYDGRFKDIFQDIYDREYKKR 764
KNTILKKYDGRFKDIFQ+IYD++YK +
Sbjct: 212 KNTILKKYDGRFKDIFQEIYDKQYKSQ 238
Score = 93.9 bits (223), Expect = 6e-19
Identities = 42/62 (67%), Positives = 53/62 (85%)
Frame = +2
Query: 68 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELNVYDLGMENRDKTDDQVTIDCAEA 247
KI G VV++ GDEMTRIIW+LIKEKLI P+++++L+ YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 248 IK 253
IK
Sbjct: 64 IK 65
>BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein.
Length = 414
Score = 172 bits (418), Expect = 1e-42
Identities = 76/86 (88%), Positives = 83/86 (96%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
K++NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW
Sbjct: 65 KKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGW 124
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAG 507
KPIIIGRHA+ DQY+ATDFVVPG G
Sbjct: 125 VKPIIIGRHAYGDQYRATDFVVPGPG 150
Score = 114 bits (275), Expect = 3e-25
Identities = 52/87 (59%), Positives = 69/87 (79%), Gaps = 2/87 (2%)
Frame = +3
Query: 510 LEIIFKPESG-EAIKHVVHEYK-GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLST 683
+EI + P G + + ++VH ++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLST
Sbjct: 152 VEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLST 211
Query: 684 KNTILKKYDGRFKDIFQDIYDREYKKR 764
KNTILKKYDGRFKDIFQ+IYD++YK +
Sbjct: 212 KNTILKKYDGRFKDIFQEIYDKQYKSQ 238
Score = 93.9 bits (223), Expect = 6e-19
Identities = 42/62 (67%), Positives = 53/62 (85%)
Frame = +2
Query: 68 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELNVYDLGMENRDKTDDQVTIDCAEA 247
KI G VV++ GDEMTRIIW+LIKEKLI P+++++L+ YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 248 IK 253
IK
Sbjct: 64 IK 65
>AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 172 bits (418), Expect = 1e-42
Identities = 76/86 (88%), Positives = 83/86 (96%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
K++NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW
Sbjct: 65 KKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGW 124
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAG 507
KPIIIGRHA+ DQY+ATDFVVPG G
Sbjct: 125 VKPIIIGRHAYGDQYRATDFVVPGPG 150
Score = 114 bits (275), Expect = 3e-25
Identities = 52/87 (59%), Positives = 69/87 (79%), Gaps = 2/87 (2%)
Frame = +3
Query: 510 LEIIFKPESG-EAIKHVVHEYK-GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLST 683
+EI + P G + + ++VH ++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLST
Sbjct: 152 VEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLST 211
Query: 684 KNTILKKYDGRFKDIFQDIYDREYKKR 764
KNTILKKYDGRFKDIFQ+IYD++YK +
Sbjct: 212 KNTILKKYDGRFKDIFQEIYDKQYKSQ 238
Score = 93.9 bits (223), Expect = 6e-19
Identities = 42/62 (67%), Positives = 53/62 (85%)
Frame = +2
Query: 68 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELNVYDLGMENRDKTDDQVTIDCAEA 247
KI G VV++ GDEMTRIIW+LIKEKLI P+++++L+ YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 248 IK 253
IK
Sbjct: 64 IK 65
>AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 172 bits (418), Expect = 1e-42
Identities = 76/86 (88%), Positives = 83/86 (96%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
K++NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW
Sbjct: 65 KKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGW 124
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAG 507
KPIIIGRHA+ DQY+ATDFVVPG G
Sbjct: 125 VKPIIIGRHAYGDQYRATDFVVPGPG 150
Score = 111 bits (267), Expect = 3e-24
Identities = 51/87 (58%), Positives = 68/87 (78%), Gaps = 2/87 (2%)
Frame = +3
Query: 510 LEIIFKPESG-EAIKHVVHEYK-GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLST 683
+EI + P G + + ++VH ++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLST
Sbjct: 152 VEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLST 211
Query: 684 KNTILKKYDGRFKDIFQDIYDREYKKR 764
KNTILK YDGRFKDIFQ+IYD++YK +
Sbjct: 212 KNTILKIYDGRFKDIFQEIYDKQYKSQ 238
Score = 93.9 bits (223), Expect = 6e-19
Identities = 42/62 (67%), Positives = 53/62 (85%)
Frame = +2
Query: 68 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELNVYDLGMENRDKTDDQVTIDCAEA 247
KI G VV++ GDEMTRIIW+LIKEKLI P+++++L+ YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 248 IK 253
IK
Sbjct: 64 IK 65
>AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein.
Length = 414
Score = 172 bits (418), Expect = 1e-42
Identities = 76/86 (88%), Positives = 83/86 (96%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
K++NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW
Sbjct: 65 KKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGW 124
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAG 507
KPIIIGRHA+ DQY+ATDFVVPG G
Sbjct: 125 VKPIIIGRHAYGDQYRATDFVVPGPG 150
Score = 114 bits (275), Expect = 3e-25
Identities = 52/87 (59%), Positives = 69/87 (79%), Gaps = 2/87 (2%)
Frame = +3
Query: 510 LEIIFKPESG-EAIKHVVHEYK-GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLST 683
+EI + P G + + ++VH ++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLST
Sbjct: 152 VEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLST 211
Query: 684 KNTILKKYDGRFKDIFQDIYDREYKKR 764
KNTILKKYDGRFKDIFQ+IYD++YK +
Sbjct: 212 KNTILKKYDGRFKDIFQEIYDKQYKSQ 238
Score = 93.9 bits (223), Expect = 6e-19
Identities = 42/62 (67%), Positives = 53/62 (85%)
Frame = +2
Query: 68 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELNVYDLGMENRDKTDDQVTIDCAEA 247
KI G VV++ GDEMTRIIW+LIKEKLI P+++++L+ YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 248 IK 253
IK
Sbjct: 64 IK 65
>CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 170 bits (414), Expect = 4e-42
Identities = 75/86 (87%), Positives = 83/86 (96%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
K++NVG+KCATITPDEKRVEEFKLK+MWKSPNGTIRNILGGTVFREAIICKNIPRLV+GW
Sbjct: 65 KKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGW 124
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAG 507
+PIIIGRHA+ DQY+ATDFVVPG G
Sbjct: 125 VEPIIIGRHAYGDQYRATDFVVPGPG 150
Score = 114 bits (275), Expect = 3e-25
Identities = 52/87 (59%), Positives = 69/87 (79%), Gaps = 2/87 (2%)
Frame = +3
Query: 510 LEIIFKPESG-EAIKHVVHEYK-GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLST 683
+EI + P G + + ++VH ++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLST
Sbjct: 152 VEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLST 211
Query: 684 KNTILKKYDGRFKDIFQDIYDREYKKR 764
KNTILKKYDGRFKDIFQ+IYD++YK +
Sbjct: 212 KNTILKKYDGRFKDIFQEIYDKQYKSQ 238
Score = 94.7 bits (225), Expect = 3e-19
Identities = 42/62 (67%), Positives = 54/62 (87%)
Frame = +2
Query: 68 KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELNVYDLGMENRDKTDDQVTIDCAEA 247
KI G VV++ GDEMTRIIW+LIKEKLI+P+++++L+ YDLG+ENRD T+DQVT D AEA
Sbjct: 4 KISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDAAEA 63
Query: 248 IK 253
IK
Sbjct: 64 IK 65
>X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase
(NADP+) protein.
Length = 452
Score = 162 bits (394), Expect = 1e-39
Identities = 73/89 (82%), Positives = 77/89 (86%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
++Y+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIPRLV GW
Sbjct: 105 QKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGW 164
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAGILK 516
KPI IGRHAH DQYKATDFV AG K
Sbjct: 165 TKPITIGRHAHGDQYKATDFVADRAGTFK 193
Score = 107 bits (257), Expect = 4e-23
Identities = 46/88 (52%), Positives = 64/88 (72%), Gaps = 1/88 (1%)
Frame = +3
Query: 498 RCWYLEIIFKPESGEAIKH-VVHEYKGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLY 674
R +++F P+ G +K V+ + GV + M+NTD SI FAHS F++A+ +K+PLY
Sbjct: 188 RAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLY 247
Query: 675 LSTKNTILKKYDGRFKDIFQDIYDREYK 758
+STKNTILK YDGRFKDIFQ+I+D+ YK
Sbjct: 248 MSTKNTILKAYDGRFKDIFQEIFDKHYK 275
Score = 89.0 bits (211), Expect = 2e-17
Identities = 44/70 (62%), Positives = 53/70 (75%), Gaps = 1/70 (1%)
Frame = +2
Query: 41 YSRHRYNMSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELNVYDLGMENRDKTD 217
+ R Y +IK A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TD
Sbjct: 34 HPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTD 93
Query: 218 DQVTIDCAEA 247
DQVTID A A
Sbjct: 94 DQVTIDSALA 103
>BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 162 bits (394), Expect = 1e-39
Identities = 73/89 (82%), Positives = 77/89 (86%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
++Y+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIPRLV GW
Sbjct: 105 QKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGW 164
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAGILK 516
KPI IGRHAH DQYKATDFV AG K
Sbjct: 165 TKPITIGRHAHGDQYKATDFVADRAGTFK 193
Score = 107 bits (257), Expect = 4e-23
Identities = 46/88 (52%), Positives = 64/88 (72%), Gaps = 1/88 (1%)
Frame = +3
Query: 498 RCWYLEIIFKPESGEAIKH-VVHEYKGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLY 674
R +++F P+ G +K V+ + GV + M+NTD SI FAHS F++A+ +K+PLY
Sbjct: 188 RAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLY 247
Query: 675 LSTKNTILKKYDGRFKDIFQDIYDREYK 758
+STKNTILK YDGRFKDIFQ+I+D+ YK
Sbjct: 248 MSTKNTILKAYDGRFKDIFQEIFDKHYK 275
Score = 88.6 bits (210), Expect = 2e-17
Identities = 44/68 (64%), Positives = 52/68 (76%), Gaps = 1/68 (1%)
Frame = +2
Query: 47 RHRYNMSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELNVYDLGMENRDKTDDQ 223
R Y +IK A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQ
Sbjct: 36 RRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQ 95
Query: 224 VTIDCAEA 247
VTID A A
Sbjct: 96 VTIDSALA 103
>BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 162 bits (394), Expect = 1e-39
Identities = 73/89 (82%), Positives = 77/89 (86%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
++Y+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIPRLV GW
Sbjct: 105 QKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGW 164
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAGILK 516
KPI IGRHAH DQYKATDFV AG K
Sbjct: 165 TKPITIGRHAHGDQYKATDFVADRAGTFK 193
Score = 107 bits (257), Expect = 4e-23
Identities = 46/88 (52%), Positives = 64/88 (72%), Gaps = 1/88 (1%)
Frame = +3
Query: 498 RCWYLEIIFKPESGEAIKH-VVHEYKGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLY 674
R +++F P+ G +K V+ + GV + M+NTD SI FAHS F++A+ +K+PLY
Sbjct: 188 RAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLY 247
Query: 675 LSTKNTILKKYDGRFKDIFQDIYDREYK 758
+STKNTILK YDGRFKDIFQ+I+D+ YK
Sbjct: 248 MSTKNTILKAYDGRFKDIFQEIFDKHYK 275
Score = 88.6 bits (210), Expect = 2e-17
Identities = 44/68 (64%), Positives = 52/68 (76%), Gaps = 1/68 (1%)
Frame = +2
Query: 47 RHRYNMSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELNVYDLGMENRDKTDDQ 223
R Y +IK A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQ
Sbjct: 36 RRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQ 95
Query: 224 VTIDCAEA 247
VTID A A
Sbjct: 96 VTIDSALA 103
>AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial precursor variant protein.
Length = 452
Score = 162 bits (394), Expect = 1e-39
Identities = 73/89 (82%), Positives = 77/89 (86%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
++Y+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIPRLV GW
Sbjct: 105 QKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGW 164
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAGILK 516
KPI IGRHAH DQYKATDFV AG K
Sbjct: 165 TKPITIGRHAHGDQYKATDFVADRAGTFK 193
Score = 105 bits (253), Expect = 1e-22
Identities = 45/88 (51%), Positives = 64/88 (72%), Gaps = 1/88 (1%)
Frame = +3
Query: 498 RCWYLEIIFKPESGEAIKH-VVHEYKGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLY 674
R +++F P+ G +K V+ + GV + M+NTD SI FAHS F++A+ +K+PLY
Sbjct: 188 RAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLY 247
Query: 675 LSTKNTILKKYDGRFKDIFQDIYDREYK 758
+STKNTILK YDGRFKDIFQ+I+D+ Y+
Sbjct: 248 MSTKNTILKAYDGRFKDIFQEIFDKHYE 275
Score = 88.6 bits (210), Expect = 2e-17
Identities = 44/68 (64%), Positives = 52/68 (76%), Gaps = 1/68 (1%)
Frame = +2
Query: 47 RHRYNMSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELNVYDLGMENRDKTDDQ 223
R Y +IK A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQ
Sbjct: 36 RRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQ 95
Query: 224 VTIDCAEA 247
VTID A A
Sbjct: 96 VTIDSALA 103
>U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase
protein.
Length = 419
Score = 159 bits (387), Expect = 8e-39
Identities = 72/89 (80%), Positives = 76/89 (85%)
Frame = +1
Query: 250 KEYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGW 429
++Y+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNI GGTVFRE IICKNIPRLV GW
Sbjct: 72 QKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNIHGGTVFREPIICKNIPRLVPGW 131
Query: 430 DKPIIIGRHAHADQYKATDFVVPGAGILK 516
KPI IGRHAH DQYKATDFV AG K
Sbjct: 132 TKPITIGRHAHGDQYKATDFVADRAGTFK 160
Score = 107 bits (257), Expect = 4e-23
Identities = 46/88 (52%), Positives = 64/88 (72%), Gaps = 1/88 (1%)
Frame = +3
Query: 498 RCWYLEIIFKPESGEAIKH-VVHEYKGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLY 674
R +++F P+ G +K V+ + GV + M+NTD SI FAHS F++A+ +K+PLY
Sbjct: 155 RAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLY 214
Query: 675 LSTKNTILKKYDGRFKDIFQDIYDREYK 758
+STKNTILK YDGRFKDIFQ+I+D+ YK
Sbjct: 215 MSTKNTILKAYDGRFKDIFQEIFDKHYK 242
Score = 44.8 bits (101), Expect = 3e-04
Identities = 19/29 (65%), Positives = 24/29 (82%)
Frame = +2
Query: 161 LDIELNVYDLGMENRDKTDDQVTIDCAEA 247
LD++L +DLG+ NRD+TDDQVTID A A
Sbjct: 42 LDVQLKYFDLGLPNRDQTDDQVTIDSALA 70
>U62389-1|AAB17375.1| 154|Homo sapiens putative cytosolic
NADP-dependent isocitrate dehydrogenase protein.
Length = 154
Score = 114 bits (275), Expect = 3e-25
Identities = 52/87 (59%), Positives = 69/87 (79%), Gaps = 2/87 (2%)
Frame = +3
Query: 510 LEIIFKPESG-EAIKHVVHEYK-GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLST 683
+EI + P G + + ++VH ++ G GVA+ M+N D SI DFAHSSF+ AL + +PLYLST
Sbjct: 53 VEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLST 112
Query: 684 KNTILKKYDGRFKDIFQDIYDREYKKR 764
KNTILKKYDGRFKDIFQ+IYD++YK +
Sbjct: 113 KNTILKKYDGRFKDIFQEIYDKQYKSQ 139
Score = 99.5 bits (237), Expect = 1e-20
Identities = 44/51 (86%), Positives = 47/51 (92%)
Frame = +1
Query: 355 RNILGGTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAG 507
RNILGGTVF EAIICKNIPRLV+GW KPIIIGRHA+ DQY+ATDFVVPG G
Sbjct: 1 RNILGGTVFXEAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPG 51
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 112,092,942
Number of Sequences: 237096
Number of extensions: 2399520
Number of successful extensions: 4439
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 4193
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4439
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 9311505506
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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