Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= pg--0293.Seq
(845 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
M33493-1|AAA36780.1| 267|Homo sapiens protein ( Human tryptase-... 31 4.0
BC133695-1|AAI33696.1| 228|Homo sapiens TESSP5 protein protein. 31 4.0
BC069143-1|AAH69143.1| 242|Homo sapiens tryptase delta 1 protein. 31 4.0
AF206667-1|AAG35697.1| 213|Homo sapiens mast cell beta I trypta... 31 4.0
AF099143-1|AAD17859.2| 275|Homo sapiens mast cell tryptase beta... 31 4.0
AE006466-5|AAK61270.1| 233|Homo sapiens mast cell tryptase beta... 31 4.0
S55551-1|AAD13876.1| 275|Homo sapiens beta-tryptase protein. 31 5.3
M37488-1|AAA51843.1| 275|Homo sapiens beta-tryptase protein. 31 5.3
M33494-1|AAC83172.1| 275|Homo sapiens tryptase-I protein. 31 5.3
M33492-1|AAA36779.1| 274|Homo sapiens protein ( Human tryptase-... 31 5.3
M33491-1|AAA36778.1| 273|Homo sapiens protein ( Human tryptase-... 31 5.3
L36936-1|AAA57257.1| 230|Homo sapiens metase protein. 31 5.3
L23134-1|AAA59582.1| 257|Homo sapiens metase protein. 31 5.3
BC074975-1|AAH74975.1| 275|Homo sapiens tryptase alpha/beta 1, ... 31 5.3
BC074974-1|AAH74974.1| 275|Homo sapiens tryptase beta 2 protein. 31 5.3
BC065923-1|AAH65923.1| 282|Homo sapiens TPSB2 protein protein. 31 5.3
BC029356-1|AAH29356.1| 275|Homo sapiens tryptase beta 2 protein. 31 5.3
BC025701-1|AAH25701.1| 257|Homo sapiens granzyme M (lymphocyte ... 31 5.3
AF318074-1|AAK12909.1| 235|Homo sapiens hmMCP-3-like tryptase I... 31 5.3
AF206664-1|AAG35694.1| 190|Homo sapiens mast cell mMCP-7-like d... 31 5.3
AF099144-1|AAD17860.1| 275|Homo sapiens mast cell tryptase beta... 31 5.3
AF098327-1|AAD17845.1| 242|Homo sapiens putative mast cell mMCP... 31 5.3
AE006466-7|AAK61272.1| 242|Homo sapiens putative mast cell MMCP... 31 5.3
AE006466-6|AAK61271.1| 275|Homo sapiens tryptase I protein. 31 5.3
M30038-1|AAA86934.1| 275|Homo sapiens tryptase precursor protein. 31 6.9
BC051852-1|AAH51852.1| 276|Homo sapiens TPSAB1 protein protein. 31 6.9
BC028059-1|AAH28059.1| 275|Homo sapiens TPSAB1 protein protein. 31 6.9
AF206666-1|AAG35696.1| 251|Homo sapiens mast cell alpha II tryp... 31 6.9
AF206665-1|AAG35695.1| 275|Homo sapiens mast cell alpha II tryp... 31 6.9
AF098328-1|AAD17846.1| 275|Homo sapiens tryptase alpha II protein. 31 6.9
X56132-2|CAA39598.1| 215|Homo sapiens protein ( Human mRNA for ... 30 9.2
X56132-1|CAA39597.1| 237|Homo sapiens protein ( Human mRNA for ... 30 9.2
X55668-1|CAA39203.1| 254|Homo sapiens proteinase 3 protein. 30 9.2
M96839-1|AAB59493.1| 235|Homo sapiens proteinase 3 protein. 30 9.2
M29142-1|AAA36342.1| 215|Homo sapiens myeloblastin protein. 30 9.2
BC096186-1|AAH96186.1| 256|Homo sapiens proteinase 3 (serine pr... 30 9.2
BC096185-1|AAH96185.1| 256|Homo sapiens proteinase 3 (serine pr... 30 9.2
BC096184-1|AAH96184.1| 256|Homo sapiens proteinase 3 (serine pr... 30 9.2
BC096183-1|AAH96183.1| 256|Homo sapiens proteinase 3 (serine pr... 30 9.2
AF421357-1|AAL86695.1| 130|Homo sapiens delta I tryptase protein. 30 9.2
AF099147-1|AAD17861.1| 166|Homo sapiens mast cell mMCP-7-like I... 30 9.2
AF015449-1|AAD21524.1| 200|Homo sapiens proteinase 3 protein. 30 9.2
>M33493-1|AAA36780.1| 267|Homo sapiens protein ( Human tryptase-III
mRNA, 3' end. ).
Length = 267
Score = 31.5 bits (68), Expect = 4.0
Identities = 15/26 (57%), Positives = 18/26 (69%)
Frame = +3
Query: 666 RQKLNVYVGGGSLIHPNVVLTAAHYV 743
R + ++ GGSLIHP VLTAAH V
Sbjct: 43 RDRYWMHFCGGSLIHPQWVLTAAHCV 68
>BC133695-1|AAI33696.1| 228|Homo sapiens TESSP5 protein protein.
Length = 228
Score = 31.5 bits (68), Expect = 4.0
Identities = 14/27 (51%), Positives = 19/27 (70%)
Frame = +3
Query: 678 NVYVGGGSLIHPNVVLTAAHYVAAAKE 758
N +V GG+LI P+ V+TAAH + KE
Sbjct: 15 NEHVCGGALIDPSWVVTAAHCIQGTKE 41
>BC069143-1|AAH69143.1| 242|Homo sapiens tryptase delta 1 protein.
Length = 242
Score = 31.5 bits (68), Expect = 4.0
Identities = 15/26 (57%), Positives = 18/26 (69%)
Frame = +3
Query: 666 RQKLNVYVGGGSLIHPNVVLTAAHYV 743
R + ++ GGSLIHP VLTAAH V
Sbjct: 58 RDRYWMHFCGGSLIHPQWVLTAAHCV 83
>AF206667-1|AAG35697.1| 213|Homo sapiens mast cell beta I tryptase
protein.
Length = 213
Score = 31.5 bits (68), Expect = 4.0
Identities = 16/26 (61%), Positives = 18/26 (69%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYVAAAKELRSE 770
GGSLIHP VLTAAH V +LR +
Sbjct: 7 GGSLIHPQWVLTAAHCVGPV-QLREQ 31
>AF099143-1|AAD17859.2| 275|Homo sapiens mast cell tryptase beta
III protein.
Length = 275
Score = 31.5 bits (68), Expect = 4.0
Identities = 15/26 (57%), Positives = 18/26 (69%)
Frame = +3
Query: 666 RQKLNVYVGGGSLIHPNVVLTAAHYV 743
R + ++ GGSLIHP VLTAAH V
Sbjct: 51 RDRYWMHFCGGSLIHPQWVLTAAHCV 76
>AE006466-5|AAK61270.1| 233|Homo sapiens mast cell tryptase beta
III protein.
Length = 233
Score = 31.5 bits (68), Expect = 4.0
Identities = 15/26 (57%), Positives = 18/26 (69%)
Frame = +3
Query: 666 RQKLNVYVGGGSLIHPNVVLTAAHYV 743
R + ++ GGSLIHP VLTAAH V
Sbjct: 51 RDRYWMHFCGGSLIHPQWVLTAAHCV 76
>S55551-1|AAD13876.1| 275|Homo sapiens beta-tryptase protein.
Length = 275
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 60 GGSLIHPQWVLTAAHCV 76
>M37488-1|AAA51843.1| 275|Homo sapiens beta-tryptase protein.
Length = 275
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 60 GGSLIHPQWVLTAAHCV 76
>M33494-1|AAC83172.1| 275|Homo sapiens tryptase-I protein.
Length = 275
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 60 GGSLIHPQWVLTAAHCV 76
>M33492-1|AAA36779.1| 274|Homo sapiens protein ( Human tryptase-II
mRNA, 3' end. ).
Length = 274
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 59 GGSLIHPQWVLTAAHCV 75
>M33491-1|AAA36778.1| 273|Homo sapiens protein ( Human tryptase-I
mRNA, 3' end. ).
Length = 273
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 58 GGSLIHPQWVLTAAHCV 74
>L36936-1|AAA57257.1| 230|Homo sapiens metase protein.
Length = 230
Score = 31.1 bits (67), Expect = 5.3
Identities = 16/34 (47%), Positives = 21/34 (61%)
Frame = +3
Query: 645 SR*QRARRQKLNVYVGGGSLIHPNVVLTAAHYVA 746
SR A Q+ ++ GG L+HP VLTAAH +A
Sbjct: 17 SRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLA 50
>L23134-1|AAA59582.1| 257|Homo sapiens metase protein.
Length = 257
Score = 31.1 bits (67), Expect = 5.3
Identities = 16/34 (47%), Positives = 21/34 (61%)
Frame = +3
Query: 645 SR*QRARRQKLNVYVGGGSLIHPNVVLTAAHYVA 746
SR A Q+ ++ GG L+HP VLTAAH +A
Sbjct: 36 SRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLA 69
>BC074975-1|AAH74975.1| 275|Homo sapiens tryptase alpha/beta 1,
precursor protein.
Length = 275
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 60 GGSLIHPQWVLTAAHCV 76
>BC074974-1|AAH74974.1| 275|Homo sapiens tryptase beta 2 protein.
Length = 275
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 60 GGSLIHPQWVLTAAHCV 76
>BC065923-1|AAH65923.1| 282|Homo sapiens TPSB2 protein protein.
Length = 282
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 67 GGSLIHPQWVLTAAHCV 83
>BC029356-1|AAH29356.1| 275|Homo sapiens tryptase beta 2 protein.
Length = 275
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 60 GGSLIHPQWVLTAAHCV 76
>BC025701-1|AAH25701.1| 257|Homo sapiens granzyme M (lymphocyte
met-ase 1) protein.
Length = 257
Score = 31.1 bits (67), Expect = 5.3
Identities = 16/34 (47%), Positives = 21/34 (61%)
Frame = +3
Query: 645 SR*QRARRQKLNVYVGGGSLIHPNVVLTAAHYVA 746
SR A Q+ ++ GG L+HP VLTAAH +A
Sbjct: 36 SRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLA 69
>AF318074-1|AAK12909.1| 235|Homo sapiens hmMCP-3-like tryptase III
protein.
Length = 235
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 60 GGSLIHPQWVLTAAHCV 76
>AF206664-1|AAG35694.1| 190|Homo sapiens mast cell mMCP-7-like
delta II tryptase protein.
Length = 190
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 15 GGSLIHPQWVLTAAHCV 31
>AF099144-1|AAD17860.1| 275|Homo sapiens mast cell tryptase beta I
protein.
Length = 275
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 60 GGSLIHPQWVLTAAHCV 76
>AF098327-1|AAD17845.1| 242|Homo sapiens putative mast cell
mMCP-7-like II typtase protein.
Length = 242
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 67 GGSLIHPQWVLTAAHCV 83
>AE006466-7|AAK61272.1| 242|Homo sapiens putative mast cell
MMCP-7-like II tryptase (MMCP-7-LIKE-2) protein.
Length = 242
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 67 GGSLIHPQWVLTAAHCV 83
>AE006466-6|AAK61271.1| 275|Homo sapiens tryptase I protein.
Length = 275
Score = 31.1 bits (67), Expect = 5.3
Identities = 14/17 (82%), Positives = 14/17 (82%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAHYV 743
GGSLIHP VLTAAH V
Sbjct: 60 GGSLIHPQWVLTAAHCV 76
>M30038-1|AAA86934.1| 275|Homo sapiens tryptase precursor protein.
Length = 275
Score = 30.7 bits (66), Expect = 6.9
Identities = 14/24 (58%), Positives = 17/24 (70%)
Frame = +3
Query: 666 RQKLNVYVGGGSLIHPNVVLTAAH 737
R + ++ GGSLIHP VLTAAH
Sbjct: 51 RDRYWMHFCGGSLIHPQWVLTAAH 74
>BC051852-1|AAH51852.1| 276|Homo sapiens TPSAB1 protein protein.
Length = 276
Score = 30.7 bits (66), Expect = 6.9
Identities = 14/24 (58%), Positives = 17/24 (70%)
Frame = +3
Query: 666 RQKLNVYVGGGSLIHPNVVLTAAH 737
R + ++ GGSLIHP VLTAAH
Sbjct: 52 RDRYWMHFCGGSLIHPQWVLTAAH 75
>BC028059-1|AAH28059.1| 275|Homo sapiens TPSAB1 protein protein.
Length = 275
Score = 30.7 bits (66), Expect = 6.9
Identities = 14/24 (58%), Positives = 17/24 (70%)
Frame = +3
Query: 666 RQKLNVYVGGGSLIHPNVVLTAAH 737
R + ++ GGSLIHP VLTAAH
Sbjct: 51 RDRYWMHFCGGSLIHPQWVLTAAH 74
>AF206666-1|AAG35696.1| 251|Homo sapiens mast cell alpha II
tryptase protein.
Length = 251
Score = 30.7 bits (66), Expect = 6.9
Identities = 14/24 (58%), Positives = 17/24 (70%)
Frame = +3
Query: 666 RQKLNVYVGGGSLIHPNVVLTAAH 737
R + ++ GGSLIHP VLTAAH
Sbjct: 36 RDRYWMHFCGGSLIHPQWVLTAAH 59
>AF206665-1|AAG35695.1| 275|Homo sapiens mast cell alpha II
tryptase protein.
Length = 275
Score = 30.7 bits (66), Expect = 6.9
Identities = 14/24 (58%), Positives = 17/24 (70%)
Frame = +3
Query: 666 RQKLNVYVGGGSLIHPNVVLTAAH 737
R + ++ GGSLIHP VLTAAH
Sbjct: 51 RDRYWMHFCGGSLIHPQWVLTAAH 74
>AF098328-1|AAD17846.1| 275|Homo sapiens tryptase alpha II protein.
Length = 275
Score = 30.7 bits (66), Expect = 6.9
Identities = 14/24 (58%), Positives = 17/24 (70%)
Frame = +3
Query: 666 RQKLNVYVGGGSLIHPNVVLTAAH 737
R + ++ GGSLIHP VLTAAH
Sbjct: 51 RDRYWMHFCGGSLIHPQWVLTAAH 74
>X56132-2|CAA39598.1| 215|Homo sapiens protein ( Human mRNA for
proteinase 3 (PR-3), Wegner's autoantigen. ).
Length = 215
Score = 30.3 bits (65), Expect = 9.2
Identities = 12/15 (80%), Positives = 14/15 (93%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAH 737
GG+LIHP+ VLTAAH
Sbjct: 16 GGTLIHPSFVLTAAH 30
>X56132-1|CAA39597.1| 237|Homo sapiens protein ( Human mRNA for
proteinase 3 (PR-3), Wegner's autoantigen. ).
Length = 237
Score = 30.3 bits (65), Expect = 9.2
Identities = 12/15 (80%), Positives = 14/15 (93%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAH 737
GG+LIHP+ VLTAAH
Sbjct: 38 GGTLIHPSFVLTAAH 52
>X55668-1|CAA39203.1| 254|Homo sapiens proteinase 3 protein.
Length = 254
Score = 30.3 bits (65), Expect = 9.2
Identities = 12/15 (80%), Positives = 14/15 (93%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAH 737
GG+LIHP+ VLTAAH
Sbjct: 56 GGTLIHPSFVLTAAH 70
>M96839-1|AAB59493.1| 235|Homo sapiens proteinase 3 protein.
Length = 235
Score = 30.3 bits (65), Expect = 9.2
Identities = 12/15 (80%), Positives = 14/15 (93%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAH 737
GG+LIHP+ VLTAAH
Sbjct: 36 GGTLIHPSFVLTAAH 50
>M29142-1|AAA36342.1| 215|Homo sapiens myeloblastin protein.
Length = 215
Score = 30.3 bits (65), Expect = 9.2
Identities = 12/15 (80%), Positives = 14/15 (93%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAH 737
GG+LIHP+ VLTAAH
Sbjct: 16 GGTLIHPSFVLTAAH 30
>BC096186-1|AAH96186.1| 256|Homo sapiens proteinase 3 (serine
proteinase, neutrophil, Wegener granulomatosis
autoantigen protein.
Length = 256
Score = 30.3 bits (65), Expect = 9.2
Identities = 12/15 (80%), Positives = 14/15 (93%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAH 737
GG+LIHP+ VLTAAH
Sbjct: 57 GGTLIHPSFVLTAAH 71
>BC096185-1|AAH96185.1| 256|Homo sapiens proteinase 3 (serine
proteinase, neutrophil, Wegener granulomatosis
autoantigen protein.
Length = 256
Score = 30.3 bits (65), Expect = 9.2
Identities = 12/15 (80%), Positives = 14/15 (93%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAH 737
GG+LIHP+ VLTAAH
Sbjct: 57 GGTLIHPSFVLTAAH 71
>BC096184-1|AAH96184.1| 256|Homo sapiens proteinase 3 (serine
proteinase, neutrophil, Wegener granulomatosis
autoantigen protein.
Length = 256
Score = 30.3 bits (65), Expect = 9.2
Identities = 12/15 (80%), Positives = 14/15 (93%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAH 737
GG+LIHP+ VLTAAH
Sbjct: 57 GGTLIHPSFVLTAAH 71
>BC096183-1|AAH96183.1| 256|Homo sapiens proteinase 3 (serine
proteinase, neutrophil, Wegener granulomatosis
autoantigen protein.
Length = 256
Score = 30.3 bits (65), Expect = 9.2
Identities = 12/15 (80%), Positives = 14/15 (93%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAH 737
GG+LIHP+ VLTAAH
Sbjct: 57 GGTLIHPSFVLTAAH 71
>AF421357-1|AAL86695.1| 130|Homo sapiens delta I tryptase protein.
Length = 130
Score = 30.3 bits (65), Expect = 9.2
Identities = 13/15 (86%), Positives = 13/15 (86%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAH 737
GGSLIHP VLTAAH
Sbjct: 28 GGSLIHPQWVLTAAH 42
>AF099147-1|AAD17861.1| 166|Homo sapiens mast cell mMCP-7-like I
protein protein.
Length = 166
Score = 30.3 bits (65), Expect = 9.2
Identities = 13/15 (86%), Positives = 13/15 (86%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAH 737
GGSLIHP VLTAAH
Sbjct: 60 GGSLIHPQWVLTAAH 74
>AF015449-1|AAD21524.1| 200|Homo sapiens proteinase 3 protein.
Length = 200
Score = 30.3 bits (65), Expect = 9.2
Identities = 12/15 (80%), Positives = 14/15 (93%)
Frame = +3
Query: 693 GGSLIHPNVVLTAAH 737
GG+LIHP+ VLTAAH
Sbjct: 57 GGTLIHPSFVLTAAH 71
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 120,011,035
Number of Sequences: 237096
Number of extensions: 2363517
Number of successful extensions: 6553
Number of sequences better than 10.0: 42
Number of HSP's better than 10.0 without gapping: 6086
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6550
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 10705443456
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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