Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= pg--0223.Seq
(782 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate dehydr... 130 4e-29
UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase... 126 5e-28
UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate ... 122 8e-27
UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome s... 120 3e-26
UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative g... 116 9e-25
UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunction... 112 1e-23
UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes: Me... 98 2e-19
UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes: Me... 95 2e-18
UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|R... 89 2e-16
UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis thal... 88 2e-16
UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes: Me... 88 2e-16
UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes: Me... 87 5e-16
UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes: Me... 87 5e-16
UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate... 86 1e-15
UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes: Me... 86 1e-15
UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes: Me... 86 1e-15
UniRef50_O83714 Cluster: Bifunctional protein folD [Includes: Me... 85 1e-15
UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes: ... 85 2e-15
UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes: Me... 84 3e-15
UniRef50_P56467 Cluster: Bifunctional protein folD [Includes: Me... 84 3e-15
UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase... 82 1e-14
UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes: Me... 80 7e-14
UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes: Me... 80 7e-14
UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate dehydrog... 79 1e-13
UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes: Me... 79 2e-13
UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes: Me... 77 5e-13
UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolas... 77 7e-13
UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes: Me... 76 9e-13
UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes: Me... 76 1e-12
UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes: ... 76 1e-12
UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep: P... 75 2e-12
UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes: Me... 75 2e-12
UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes: Me... 75 3e-12
UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes: Me... 75 3e-12
UniRef50_UPI0000D9A063 Cluster: PREDICTED: similar to Bifunction... 74 4e-12
UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of s... 74 4e-12
UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes: Me... 74 4e-12
UniRef50_O84081 Cluster: Bifunctional protein folD [Includes: Me... 74 4e-12
UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes: Me... 74 5e-12
UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes: Me... 73 6e-12
UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes: ... 73 6e-12
UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes: Me... 73 1e-11
UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes: Me... 73 1e-11
UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes: ... 72 1e-11
UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to ENSANGP000... 71 3e-11
UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes: Me... 69 1e-10
UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes: Me... 69 1e-10
UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes: Me... 69 1e-10
UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes: Me... 69 1e-10
UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes: ... 69 1e-10
UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase... 69 2e-10
UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes: Me... 69 2e-10
UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplas... 69 2e-10
UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase... 68 2e-10
UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes: Me... 68 2e-10
UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes: ... 68 3e-10
UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes: Me... 67 4e-10
UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes: Me... 67 5e-10
UniRef50_UPI000038C811 Cluster: COG0190: 5,10-methylene-tetrahyd... 66 7e-10
UniRef50_O51057 Cluster: Bifunctional protein folD [Includes: Me... 66 7e-10
UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes: ... 66 7e-10
UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes: ... 66 7e-10
UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate dehydrogenase... 66 9e-10
UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes: Me... 66 9e-10
UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147, w... 65 2e-09
UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes: Me... 65 2e-09
UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes: Me... 65 2e-09
UniRef50_UPI0000D9D4E1 Cluster: PREDICTED: similar to Bifunction... 64 3e-09
UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase... 64 4e-09
UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes: Me... 64 4e-09
UniRef50_A6LP88 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 62 1e-08
UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycopla... 62 2e-08
UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes: Me... 62 2e-08
UniRef50_A4M873 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 62 2e-08
UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes: Me... 61 3e-08
UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121... 60 8e-08
UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes: Me... 60 8e-08
UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillu... 59 1e-07
UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes: Me... 59 1e-07
UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, wh... 58 2e-07
UniRef50_UPI00015563B5 Cluster: PREDICTED: similar to Mthfd2-pro... 57 4e-07
UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes: ... 57 4e-07
UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes: Me... 57 6e-07
UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whol... 56 1e-06
UniRef50_Q6L046 Cluster: Bifunctional protein folD [Includes: Me... 56 1e-06
UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1; ... 55 2e-06
UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes: Me... 54 5e-06
UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes: Me... 53 7e-06
UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate dehydr... 52 2e-05
UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes: Me... 52 2e-05
UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes: ... 52 2e-05
UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3; ... 48 4e-04
UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate dehydrogenase... 47 6e-04
UniRef50_UPI00006CB712 Cluster: tetrahydrofolate dehydrogenase/c... 46 8e-04
UniRef50_Q21285 Cluster: Dauer or aging adult overexpression pro... 46 8e-04
UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1; Schis... 44 0.006
UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes: Me... 42 0.023
UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes: Me... 41 0.030
UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome s... 41 0.040
UniRef50_Q4DH06 Cluster: Methylenetetrahydrofolate dehydrogenase... 40 0.053
UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate for... 36 0.86
UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase... 36 1.1
UniRef50_P47259 Cluster: Bifunctional protein folD [Includes: Me... 36 1.1
UniRef50_Q6LTH4 Cluster: Putative uncharacterized protein; n=3; ... 34 4.6
UniRef50_Q62L13 Cluster: Hydrolase; n=16; Burkholderia|Rep: Hydr... 34 4.6
UniRef50_Q6X5D4 Cluster: Methylene-THF dehydrogenase; n=1; Trepo... 34 4.6
UniRef50_Q7NAE4 Cluster: Bifunctional protein folD [Includes: Me... 34 4.6
UniRef50_Q55FD5 Cluster: Putative glycosyltransferase; n=1; Dict... 33 6.1
UniRef50_Q4S3A9 Cluster: Chromosome 4 SCAF14752, whole genome sh... 33 8.1
UniRef50_A7NLG5 Cluster: Sodium/hydrogen exchanger; n=1; Roseifl... 33 8.1
UniRef50_Q8ILG1 Cluster: Putative uncharacterized protein; n=3; ... 33 8.1
>UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2-like; n=1; Takifugu
rubripes|Rep: methylenetetrahydrofolate dehydrogenase
(NADP+ dependent) 2-like - Takifugu rubripes
Length = 400
Score = 130 bits (314), Expect = 4e-29
Identities = 58/87 (66%), Positives = 73/87 (83%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P+ INER VC+AIAPEKD+DGFHI+NIG+LC+D ++VPAT AV E++KR I+
Sbjct: 101 VQLPLPEHINERAVCNAIAPEKDVDGFHIVNIGKLCLDQRSMVPATPAAVWEIIKRAGIE 160
Query: 691 TFGRNAVVIGRSKNVGMPIAMMLHATR 771
T G+N +V GRSKNVGMPIAM+LH R
Sbjct: 161 TVGKNVLVAGRSKNVGMPIAMLLHTDR 187
Score = 77.0 bits (181), Expect = 5e-13
Identities = 33/85 (38%), Positives = 57/85 (67%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
+A +I++E+++ + + V+ GN P + ++VG+DPAS TYV+NK AA +GI + T+ R
Sbjct: 15 LARQIQREIQRDVEELVAQGNMRPHLGVVLVGEDPASRTYVKNKTRAASILGISSDTVVR 74
Query: 434 DSDITEEQLLSEIQNLNEDNNVDGI 508
S +++E+LL I +N D V G+
Sbjct: 75 PSSVSQEELLELIDKMNRDWRVSGL 99
>UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=4; cellular organisms|Rep: Methylenetetrahydrofolate
dehydrogenase - Aedes aegypti (Yellowfever mosquito)
Length = 337
Score = 126 bits (305), Expect = 5e-28
Identities = 55/85 (64%), Positives = 73/85 (85%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLPVP INER+VC++++ +KD+DGF+ NIGRLC+D+ T++P T L V E++KR I+
Sbjct: 128 VQLPVPGHINERKVCNSVSCDKDVDGFNERNIGRLCLDMNTLIPCTPLGVQELIKRTEIE 187
Query: 691 TFGRNAVVIGRSKNVGMPIAMMLHA 765
TFG+NAVV+GRSKNVGMPIAM+LHA
Sbjct: 188 TFGKNAVVVGRSKNVGMPIAMLLHA 212
Score = 95.9 bits (228), Expect = 1e-18
Identities = 45/88 (51%), Positives = 66/88 (75%), Gaps = 1/88 (1%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLG-NRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALT 424
+ IA +I+ EL+++I +W+ G NRAP + I++G+DPAS+TYV NK++AA VGI + T
Sbjct: 39 KQIAADIRMELREQIEEWMKQGGNRAPHLTAILIGEDPASNTYVSNKMKAAADVGITSKT 98
Query: 425 INRDSDITEEQLLSEIQNLNEDNNVDGI 508
+DITEEQLL I+ LN+D++VDGI
Sbjct: 99 ERYSADITEEQLLKRIEELNQDDSVDGI 126
>UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)]; n=66; cellular
organisms|Rep: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Homo sapiens (Human)
Length = 350
Score = 122 bits (295), Expect = 8e-27
Identities = 51/84 (60%), Positives = 71/84 (84%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P+ I+ERR+C+A++P+KD+DGFH+IN+GR+C+D +++PAT V E++KR I
Sbjct: 131 VQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIP 190
Query: 691 TFGRNAVVIGRSKNVGMPIAMMLH 762
T G+N VV GRSKNVGMPIAM+LH
Sbjct: 191 TLGKNVVVAGRSKNVGMPIAMLLH 214
Score = 95.9 bits (228), Expect = 1e-18
Identities = 41/87 (47%), Positives = 66/87 (75%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+ +A +IK+E++Q++ +WV+ GN+ P + I+VG++PASH+YV NK AA VGI++ TI
Sbjct: 43 RKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETI 102
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+ + I+EE+LL+ I LN D+NVDG+
Sbjct: 103 MKPASISEEELLNLINKLNNDDNVDGL 129
>UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 12 SCAF14999, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 342
Score = 120 bits (290), Expect = 3e-26
Identities = 50/84 (59%), Positives = 69/84 (82%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P+ I+ER +C+A+AP KD+DGFH++N+GR+C+D +++PAT V E++KR I
Sbjct: 124 VQLPLPEHIDERTICNAVAPTKDVDGFHVVNVGRMCLDQSSMLPATPWGVWEIIKRTGIP 183
Query: 691 TFGRNAVVIGRSKNVGMPIAMMLH 762
T G+N VV GRSKNVGMPIAM+LH
Sbjct: 184 TLGKNVVVAGRSKNVGMPIAMLLH 207
Score = 89.8 bits (213), Expect = 7e-17
Identities = 40/87 (45%), Positives = 60/87 (68%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+ +A +I++E + + +WV G+R P + ++VGDDPASH+YV NK AA +GI + TI
Sbjct: 36 RKLARQIREEARADVEKWVLTGHRRPHLSVVLVGDDPASHSYVLNKTRAAADIGISSETI 95
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+ SDI+EE+LL I LN D+ VDG+
Sbjct: 96 LKHSDISEEELLDLIDKLNTDHRVDGL 122
>UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase - Nasonia
vitripennis
Length = 699
Score = 116 bits (278), Expect = 9e-25
Identities = 52/85 (61%), Positives = 67/85 (78%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLPVP+ I+ER VC A+ P KD+DGFH+ NIG L ++ I+PATAL V E++ R I
Sbjct: 122 VQLPVPEHISEREVCQAVTPTKDVDGFHLSNIGNLALNNKGIIPATALGVKELIVRSKIP 181
Query: 691 TFGRNAVVIGRSKNVGMPIAMMLHA 765
TFG+NAVVIGRSK+VG PIA++LH+
Sbjct: 182 TFGKNAVVIGRSKHVGFPIALLLHS 206
Score = 77.8 bits (183), Expect = 3e-13
Identities = 35/85 (41%), Positives = 58/85 (68%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
+A ++ +E+K ++ + G + P + I+VG++PAS YV KV+AAK VGI++ T+
Sbjct: 36 VADQVLEEVKAEVDEMTRNGEKRPKLIAILVGNNPASKAYVGRKVKAAKTVGIESETLRF 95
Query: 434 DSDITEEQLLSEIQNLNEDNNVDGI 508
+ IT+E+LL E+Q LN+D VDG+
Sbjct: 96 EDSITQEELLHEVQKLNDDPTVDGL 120
>UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Apis mellifera
Length = 407
Score = 112 bits (269), Expect = 1e-23
Identities = 50/84 (59%), Positives = 68/84 (80%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+ +NE+ VC AI P KD+DGFH+ N+G L ++ I+PATALAV E++ R NI+
Sbjct: 204 VQLPLIKHMNEQEVCQAIIPSKDVDGFHLENLGNLALNRNGIIPATALAVKELIIRNNIE 263
Query: 691 TFGRNAVVIGRSKNVGMPIAMMLH 762
TFG+NAVV+GRSK+VG+PIA++LH
Sbjct: 264 TFGKNAVVVGRSKHVGLPIALLLH 287
Score = 79.0 bits (186), Expect = 1e-13
Identities = 35/87 (40%), Positives = 57/87 (65%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+ IA +I+ ELK + W++ + P + I VG++PAS YV K++AA F+GI+ TI
Sbjct: 116 KKIANKIQNELKITVDNWINDNKKRPKLVAIKVGNNPASKIYVEKKIKAANFIGIENYTI 175
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+ D +++ +++EI NLN+D VDGI
Sbjct: 176 HLDEKSSQQDIINEIDNLNKDKTVDGI 202
>UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=52; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 296
Score = 98.3 bits (234), Expect = 2e-19
Identities = 42/83 (50%), Positives = 62/83 (74%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P I+E+++ +A+ P KD+DGFH IN+GRL + LP V AT +VE+L+R+NI
Sbjct: 99 VQLPLPKHIDEQKIIEAVDPRKDVDGFHPINVGRLSIGLPGFVSATPKGIVELLRRYNIP 158
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
T G++ VV+GRS VG P++ +L
Sbjct: 159 TRGKHCVVLGRSNIVGKPVSQLL 181
Score = 67.7 bits (158), Expect = 3e-10
Identities = 32/86 (37%), Positives = 53/86 (61%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+ I+ EIK+E+ + + + G R P + ++VG D S TY+ +KV+A + VG + I
Sbjct: 11 KKISGEIKQEIAAVVNELLEKGGRRPHLAGVLVGHDGGSETYMASKVKACEEVGFTSSLI 70
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDG 505
+ D+TEE+LL+ + LN+D VDG
Sbjct: 71 RYEDDVTEEELLACVHRLNQDPTVDG 96
>UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Erwinia carotovora subsp. atroseptica (Pectobacterium
atrosepticum)
Length = 287
Score = 94.7 bits (225), Expect = 2e-18
Identities = 41/83 (49%), Positives = 59/83 (71%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P+ I+ +V + IAP+KD+DGFH N+GRLC P + T ++ +L+R+NID
Sbjct: 97 VQLPLPEGIDNTKVIERIAPDKDVDGFHPYNVGRLCQRAPLLRACTPRGIITLLERYNID 156
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
TFG NAVV+G S VG P+++ L
Sbjct: 157 TFGLNAVVVGASNIVGRPMSLEL 179
Score = 64.9 bits (151), Expect = 2e-09
Identities = 31/87 (35%), Positives = 53/87 (60%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
++IA ++K E+ ++ Q ++ G RAP + ++VGD+PAS YV +K + + VG + +
Sbjct: 9 KTIAQQVKDEVAARVTQRLAEGKRAPGLAVVLVGDNPASQIYVTSKRKVCEEVGFISRSY 68
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+ TE +LL+ I LN D +DGI
Sbjct: 69 DLPITTTESELLALIDQLNADQAIDGI 95
>UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|Rep:
F6N23.26 protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 360
Score = 88.6 bits (210), Expect = 2e-16
Identities = 42/85 (49%), Positives = 60/85 (70%), Gaps = 2/85 (2%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLKRFN 684
VQLP+P ++E+ + +A++ EKD+DGFH +NIGRL + P VP T +E+L R+N
Sbjct: 163 VQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLAMRGREPLFVPCTPKGCIELLHRYN 222
Query: 685 IDTFGRNAVVIGRSKNVGMPIAMML 759
I+ G+ AVVIGRS VGMP A++L
Sbjct: 223 IEIKGKRAVVIGRSNIVGMPAALLL 247
Score = 56.0 bits (129), Expect = 1e-06
Identities = 28/87 (32%), Positives = 49/87 (56%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+++A +I+ E+ ++++ P + I+VGD S TYVRNK +A VGI + +
Sbjct: 75 KAVAKKIRDEITIEVSRMKESIGVIPGLAVILVGDRKDSATYVRNKKKACDSVGIKSFEV 134
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
D +EE++L + N+D +V GI
Sbjct: 135 RLAEDSSEEEVLKSVSGFNDDPSVHGI 161
>UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis
thaliana|Rep: F6N23.28 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 310
Score = 88.2 bits (209), Expect = 2e-16
Identities = 42/85 (49%), Positives = 60/85 (70%), Gaps = 2/85 (2%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLKRFN 684
VQLP+P ++E+ + +A++ EKD+DGFH +NIGRL + P VP T +E+L R+N
Sbjct: 113 VQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLAMRGREPLFVPCTPKGCIELLHRYN 172
Query: 685 IDTFGRNAVVIGRSKNVGMPIAMML 759
I+ G+ AVVIGRS VGMP A++L
Sbjct: 173 IEFKGKRAVVIGRSNIVGMPAALLL 197
>UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Acidobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acidobacteria bacterium (strain Ellin345)
Length = 307
Score = 88.2 bits (209), Expect = 2e-16
Identities = 39/83 (46%), Positives = 58/83 (69%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P ++ +++ A++PEKD+DGFH +N+G L P +VP T +E+L+R N+
Sbjct: 96 VQLPLPKQVDSKKILLAVSPEKDVDGFHPMNVGYLSTVRPGLVPCTPAGCMEILRRSNVP 155
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G +AVV+GRS VG PIAM+L
Sbjct: 156 VEGADAVVVGRSDIVGKPIAMLL 178
Score = 58.0 bits (134), Expect = 2e-07
Identities = 30/85 (35%), Positives = 50/85 (58%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
I+ EIK E+ ++A+ + G P + ++VG +PAS YVRNKV+A + GI +
Sbjct: 11 ISAEIKTEVAAEVAELKAKG-LTPGLAVVLVGHNPASEIYVRNKVKACEMTGIYSEQHTP 69
Query: 434 DSDITEEQLLSEIQNLNEDNNVDGI 508
++ LL +++LN N++DGI
Sbjct: 70 PDTVSTADLLQLVESLNRRNDIDGI 94
>UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=45; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Oceanobacillus iheyensis
Length = 285
Score = 87.0 bits (206), Expect = 5e-16
Identities = 37/83 (44%), Positives = 58/83 (69%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+PD ++E+++ AI+P KD+DGFH IN+G++ T +P T ++ ML+ +I
Sbjct: 95 VQLPLPDQMDEQKIIHAISPAKDVDGFHPINVGKMMTGEDTFIPCTPYGILTMLRSKDIS 154
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G++AV+IGRS VG PI ++L
Sbjct: 155 LEGKHAVIIGRSNIVGKPIGLLL 177
Score = 55.2 bits (127), Expect = 2e-06
Identities = 28/87 (32%), Positives = 52/87 (59%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+ ++ E+K+++K ++ + G P + I+VGD+PAS +YV+ K +A GI + I
Sbjct: 8 KELSEELKQKMKIEVDELKEKG-LTPHLTVILVGDNPASKSYVKGKEKACAVTGISSNLI 66
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+I++++LL I N D++V GI
Sbjct: 67 ELPENISQDELLQIIDEQNNDDSVHGI 93
>UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=226; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Burkholderia pseudomallei (Pseudomonas
pseudomallei)
Length = 285
Score = 87.0 bits (206), Expect = 5e-16
Identities = 41/83 (49%), Positives = 54/83 (65%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P I+ +V +AIAPEKD+DGFH+ N G L P P T V++M + + I
Sbjct: 96 VQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALLTGKPLFRPCTPYGVMKMFEAYKIP 155
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G NAVVIGRS VG P+A++L
Sbjct: 156 LQGANAVVIGRSNIVGKPMALLL 178
Score = 56.8 bits (131), Expect = 6e-07
Identities = 28/86 (32%), Positives = 51/86 (59%)
Frame = +2
Query: 251 SIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTIN 430
+++ ++ + ++ A + G+R P + I+VGD+PAS YVRNK++A + G +L
Sbjct: 10 ALSKTLRAQAAERAAALAARGHR-PGLAVILVGDNPASEVYVRNKIKACEDNGFFSLKDR 68
Query: 431 RDSDITEEQLLSEIQNLNEDNNVDGI 508
+ ++E +LL+ I LN D + GI
Sbjct: 69 YPATLSEPELLARIDELNRDPKIHGI 94
>UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate
dehydrogenase; n=1; Prototheca wickerhamii|Rep: Plastid
5,10-methylene-tetrahydrofolate dehydrogenase -
Prototheca wickerhamii
Length = 248
Score = 85.8 bits (203), Expect = 1e-15
Identities = 43/85 (50%), Positives = 57/85 (67%), Gaps = 2/85 (2%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV--DLPTIVPATALAVVEMLKRFN 684
VQLP+P+ INE+RV DAI+ EKD+DGFH NIG L + PT V T +E+LKR
Sbjct: 156 VQLPLPEHINEKRVLDAISLEKDVDGFHPNNIGELAMRGRSPTYVSCTPKGCLELLKRAG 215
Query: 685 IDTFGRNAVVIGRSKNVGMPIAMML 759
+ G+ A V+GRS VG+P A++L
Sbjct: 216 VTLAGKRAAVVGRSNIVGLPAALLL 240
Score = 57.2 bits (132), Expect = 4e-07
Identities = 30/87 (34%), Positives = 50/87 (57%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+ IA I+ ELK ++ + + N P + ++VG+ S TYVR+K +A VGI++
Sbjct: 68 KKIAETIRGELKVEVDELRAQYNTVPGLAVVLVGERKDSQTYVRSKKKACDEVGINSFGA 127
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+ TEE++L+ + N+D NV GI
Sbjct: 128 DLPETATEEEVLAVVAKFNDDPNVHGI 154
>UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=9; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pelobacter propionicus (strain DSM 2379)
Length = 283
Score = 85.8 bits (203), Expect = 1e-15
Identities = 41/89 (46%), Positives = 55/89 (61%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P I+ +V +AI+P KD+DGFH N+GRL V P P T V+ ML+ ++
Sbjct: 95 VQLPLPSQIDTDKVLEAISPFKDVDGFHPYNVGRLSVGKPVFQPCTPYGVMVMLREAGVE 154
Query: 691 TFGRNAVVIGRSKNVGMPIAMMLHATRDT 777
G+ VV+GRS VG P+AMM A T
Sbjct: 155 LKGKEVVVVGRSNIVGKPVAMMCLAEHAT 183
>UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=27; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Desulfotalea psychrophila
Length = 296
Score = 85.8 bits (203), Expect = 1e-15
Identities = 42/85 (49%), Positives = 55/85 (64%), Gaps = 2/85 (2%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV--DLPTIVPATALAVVEMLKRFN 684
VQLP+P INE+ + AI P+KD+D FH +NIGRL + D +P T + EML R
Sbjct: 97 VQLPLPKHINEQNIITAIDPDKDVDAFHPVNIGRLMIGGDDVKFLPCTPAGIQEMLVRSG 156
Query: 685 IDTFGRNAVVIGRSKNVGMPIAMML 759
++T G VV+GRS VG PIAMM+
Sbjct: 157 VETAGAEVVVVGRSNIVGKPIAMMM 181
Score = 48.4 bits (110), Expect = 2e-04
Identities = 25/85 (29%), Positives = 45/85 (52%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
I EI E+K + + P + I+VG+ PAS +YV K++ A +G + +
Sbjct: 11 IRKEILGEIKDAVTEMKDKYGTVPGLVTILVGESPASMSYVSLKIKTALSLGFYEVQESL 70
Query: 434 DSDITEEQLLSEIQNLNEDNNVDGI 508
+ TE +LL+ I+ N D+++ G+
Sbjct: 71 SVETTEAELLALIEKYNNDDSIHGV 95
>UniRef50_O83714 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Treponema pallidum
Length = 315
Score = 85.4 bits (202), Expect = 1e-15
Identities = 37/83 (44%), Positives = 54/83 (65%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+QLP+P ++ RVC A+APEKD+DGFH +N G L + P VP T +V +L+R +
Sbjct: 97 IQLPLPAHLDAARVCRAVAPEKDVDGFHPLNCGALFLAQPGFVPCTPAGIVHLLRRAQVP 156
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G V++GRS VG P+A++L
Sbjct: 157 LAGARVVIVGRSAIVGRPLAVLL 179
Score = 44.0 bits (99), Expect = 0.004
Identities = 25/63 (39%), Positives = 32/63 (50%)
Frame = +2
Query: 320 APTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNNV 499
AP + ++VGDDPAS TYV K A + T + + Q+L I LNED V
Sbjct: 33 APFLAAVLVGDDPASCTYVAAKQRALARAHLRGETHRLPAHASHAQVLELIARLNEDARV 92
Query: 500 DGI 508
GI
Sbjct: 93 HGI 95
>UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Geobacter sulfurreducens
Length = 290
Score = 85.0 bits (201), Expect = 2e-15
Identities = 40/83 (48%), Positives = 56/83 (67%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P IN++ V +AIAPEKDIDGFH N GR+ + PATA + ++L+ + +
Sbjct: 95 VQLPLPKHINQQHVINAIAPEKDIDGFHPANFGRMTLGQKAFRPATAYGICKLLQFYEVP 154
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
++ VVIGRS VG PI++ML
Sbjct: 155 VKAKHCVVIGRSNIVGKPISIML 177
Score = 56.0 bits (129), Expect = 1e-06
Identities = 25/84 (29%), Positives = 47/84 (55%)
Frame = +2
Query: 257 AMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRD 436
A + E+ +K+A + G R P + I+VG+ S +YV++K+ + G ++ +
Sbjct: 10 AESLVAEIARKVAGYTESGLRTPHMTIILVGEHAPSESYVKSKIATSGLAGFESTLLRFP 69
Query: 437 SDITEEQLLSEIQNLNEDNNVDGI 508
I E +LL++I+ +NED DG+
Sbjct: 70 ETIRESELLAKIKEVNEDPTTDGL 93
>UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermus thermophilus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermus thermophilus (strain HB8 / ATCC
27634 / DSM 579)
Length = 282
Score = 84.2 bits (199), Expect = 3e-15
Identities = 40/83 (48%), Positives = 54/83 (65%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P I +RV +AI P KD+DGFH +N+GRL + P T L VV +LK + +D
Sbjct: 93 VQLPLPPHIRTQRVLEAIHPLKDVDGFHPLNVGRLWSGGKGLFPCTPLGVVRLLKHYGVD 152
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G+ VV+GRS VG P+A +L
Sbjct: 153 LRGKEVVVVGRSNIVGKPLAGLL 175
Score = 50.4 bits (115), Expect = 5e-05
Identities = 27/62 (43%), Positives = 36/62 (58%)
Frame = +2
Query: 323 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNNVD 502
P++R I +G+DPAS YVR K + A+ +G + D+ EE LL I LN D VD
Sbjct: 30 PSLRVIRLGEDPASVAYVRLKDKRARALGYRSQVEVYPEDLPEEALLERIAALNADEEVD 89
Query: 503 GI 508
GI
Sbjct: 90 GI 91
>UniRef50_P56467 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Helicobacter pylori (Campylobacter pylori)
Length = 290
Score = 84.2 bits (199), Expect = 3e-15
Identities = 33/83 (39%), Positives = 58/83 (69%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P I+ + + +AI P KD+DGFH +NIG+LC + +PAT + V+ +L+ ++I+
Sbjct: 100 VQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIE 159
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G++ +IG S +G P++M++
Sbjct: 160 IKGKDVAIIGASNIIGKPLSMLM 182
Score = 67.7 bits (158), Expect = 3e-10
Identities = 35/87 (40%), Positives = 54/87 (62%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
Q++A I+K+LK KI + ++ P + I+VG DPAS TYV K++A + VG+D
Sbjct: 12 QALADNIEKDLKHKIQIITAQTHKRPKLAVILVGKDPASITYVNMKIKACERVGMDFDLK 71
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+ITE +LLS I++ N D N+ G+
Sbjct: 72 TLQENITEAKLLSLIKDYNTDQNISGV 98
>UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Halorubrum lacusprofundi ATCC 49239|Rep:
Methenyltetrahydrofolate cyclohydrolase - Halorubrum
lacusprofundi ATCC 49239
Length = 307
Score = 82.2 bits (194), Expect = 1e-14
Identities = 40/83 (48%), Positives = 55/83 (66%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLPVPD +++RRV IAP KD+DGFH N+GRL P T V ++L ++++
Sbjct: 105 VQLPVPDHVDKRRVLRQIAPVKDVDGFHPENVGRLVAGDARFKPCTPHGVQKLLAAYDVE 164
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
T G +AVV+GRS VG P+A +L
Sbjct: 165 TEGADAVVVGRSDIVGKPMANLL 187
Score = 51.6 bits (118), Expect = 2e-05
Identities = 26/87 (29%), Positives = 48/87 (55%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+++A +++ ++ + G P + +++ DDPAS TYV K + VGI+++ +
Sbjct: 18 EAVAADVRDDVAAHVETLEEEGV-TPGLATVLMSDDPASETYVSMKQRDCEEVGIESVHV 76
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
D+D E+L I +LNE +V GI
Sbjct: 77 EIDADAPAEELYETIDDLNEREDVHGI 103
>UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=90; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus elongatus (Thermosynechococcus
elongatus)
Length = 306
Score = 79.8 bits (188), Expect = 7e-14
Identities = 39/89 (43%), Positives = 57/89 (64%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+QLP+P ++ R + AI P+KD+DG H N+GRL D P + T V+++L + ID
Sbjct: 100 LQLPLPPHLDPRPLLYAIHPDKDVDGLHPENLGRLVRDEPGLRSCTPAGVMQLLAAYGID 159
Query: 691 TFGRNAVVIGRSKNVGMPIAMMLHATRDT 777
GR+AVV+GRS VG P+A+ML + T
Sbjct: 160 VVGRSAVVVGRSILVGKPLALMLLSANAT 188
Score = 65.3 bits (152), Expect = 2e-09
Identities = 33/87 (37%), Positives = 52/87 (59%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+S+A I+++L + + + R+P + + VG+DPAS YVR K +A VGI +
Sbjct: 12 KSLAQSIERQLADHVRTFQAQWGRSPGLAVLRVGNDPASAVYVRAKEQACSRVGIQSFGA 71
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+ + ITE LL++I LN+D VDGI
Sbjct: 72 HLPATITEAALLAKITELNQDERVDGI 98
>UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Alphaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Anaplasma marginale (strain St. Maries)
Length = 299
Score = 79.8 bits (188), Expect = 7e-14
Identities = 38/84 (45%), Positives = 54/84 (64%), Gaps = 1/84 (1%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV-DLPTIVPATALAVVEMLKRFNI 687
VQLP+P I++ V +AI+PEKD+DGFH N G+L L ++P T + ++K
Sbjct: 96 VQLPLPRHIDKELVINAISPEKDVDGFHNANAGKLATGQLDCMIPCTPQGCIHLIKTVKQ 155
Query: 688 DTFGRNAVVIGRSKNVGMPIAMML 759
D G NAVV+GRS VG P+A++L
Sbjct: 156 DLAGSNAVVVGRSNIVGKPVALLL 179
Score = 54.8 bits (126), Expect = 2e-06
Identities = 28/62 (45%), Positives = 38/62 (61%)
Frame = +2
Query: 323 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNNVD 502
P + +IVGDDPAS YV NK A+ +G+ + TI + D ++E+LL I LN D V
Sbjct: 33 PHLVVVIVGDDPASKLYVGNKQRKAEELGLQSRTIALEHDTSQEELLRIIDELNRDAAVH 92
Query: 503 GI 508
GI
Sbjct: 93 GI 94
>UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate
dehydrogenase/5,10- methenyltetrahydrofolate
cyclohydrolase; n=7; Eukaryota|Rep:
5,10-methylenetetrahydrofolate dehydrogenase/5,10-
methenyltetrahydrofolate cyclohydrolase - Arabidopsis
thaliana (Mouse-ear cress)
Length = 299
Score = 79.0 bits (186), Expect = 1e-13
Identities = 37/85 (43%), Positives = 56/85 (65%), Gaps = 2/85 (2%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLKRFN 684
VQLP+P INE + AI+ +KD+DGFH +NIG+L + P +P T +E+L R
Sbjct: 103 VQLPLPKHINEEHILGAISIDKDVDGFHPLNIGKLAMKGREPLFLPCTPKGCLELLARSG 162
Query: 685 IDTFGRNAVVIGRSKNVGMPIAMML 759
+ G+ AVV+GRS VG+P++++L
Sbjct: 163 VKIKGQRAVVVGRSNIVGLPVSLLL 187
Score = 51.2 bits (117), Expect = 3e-05
Identities = 27/101 (26%), Positives = 49/101 (48%)
Frame = +2
Query: 206 LCKHSKHHGAYPRWQSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNK 385
+ S H ++IA I+ E+ +++ + P + +IVG S TYV K
Sbjct: 1 MASSSDHTAKIIDGKAIAHTIRSEIAEEVRGLSEKHGKVPGLAVVIVGSRKDSQTYVNTK 60
Query: 386 VEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNNVDGI 508
+A VGI + + +++E L+S++ LN + +V GI
Sbjct: 61 RKACAEVGIKSFDVGLPEEVSEADLISKVHELNSNPDVHGI 101
>UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=44; Gammaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Vibrio cholerae
Length = 286
Score = 78.6 bits (185), Expect = 2e-13
Identities = 34/83 (40%), Positives = 55/83 (66%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P ++ +V ++I PEKD+DGFH N+GRL +P + T ++ +L+R+NI
Sbjct: 97 VQLPLPAGMDTTKVLESIHPEKDVDGFHPYNVGRLAQRIPKLRSCTPKGIITLLERYNIP 156
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G++AV++G S VG P+ + L
Sbjct: 157 LRGKHAVIVGASNIVGRPMTLEL 179
Score = 62.9 bits (146), Expect = 9e-09
Identities = 30/85 (35%), Positives = 50/85 (58%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
I+ ++ E+ ++ V G RAP + ++VG+DPAS YV +K A + VG + + +
Sbjct: 11 ISQTVRSEVAARVKARVQAGLRAPGLAVVLVGEDPASQVYVGSKRRACEEVGFVSKSFDL 70
Query: 434 DSDITEEQLLSEIQNLNEDNNVDGI 508
+ +EE LLS ++ LN D +DGI
Sbjct: 71 PATASEEALLSLVEELNNDPQIDGI 95
>UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Sphingobium chlorophenolicum|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Sphingobium
chlorophenolicum
Length = 316
Score = 77.0 bits (181), Expect = 5e-13
Identities = 37/83 (44%), Positives = 52/83 (62%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P I+ +V D I P KD+DGFH +N+ RL +VP T + + +L+ D
Sbjct: 96 VQLPLPAQIDSGKVLDTIDPRKDVDGFHPVNVFRLSTGTGGLVPCTPMGCMILLRSVLPD 155
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G+ AVVIG+S VG P+AM+L
Sbjct: 156 LKGKQAVVIGKSNIVGKPVAMLL 178
Score = 69.7 bits (163), Expect = 8e-11
Identities = 32/78 (41%), Positives = 51/78 (65%)
Frame = +2
Query: 275 ELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEE 454
+L + +A++ + APT+ ++VGDDPASH YVR K+E + VG++++ +D +EE
Sbjct: 17 DLTRDVARFSQVHGYAPTLVAVLVGDDPASHIYVRKKIEQCRKVGMESVEHRLPADCSEE 76
Query: 455 QLLSEIQNLNEDNNVDGI 508
LL+ I +LN D V GI
Sbjct: 77 DLLALIASLNADERVHGI 94
>UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolase /
NADP-dependent methylene H4F dehydrogenase; n=1;
Dictyostelium discoideum AX4|Rep: Methenyl
tetrahydrofolate cyclohydrolase / NADP-dependent
methylene H4F dehydrogenase - Dictyostelium discoideum
AX4
Length = 440
Score = 76.6 bits (180), Expect = 7e-13
Identities = 35/84 (41%), Positives = 54/84 (64%), Gaps = 1/84 (1%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDL-PTIVPATALAVVEMLKRFNI 687
VQLP+PD +N+ + +I P+KD+DG N+G++ + P +P T L ++E+LK + I
Sbjct: 180 VQLPLPDNLNKDAIIQSIDPKKDVDGLTSTNLGQIMISKKPLYIPCTPLGILEILKAYKI 239
Query: 688 DTFGRNAVVIGRSKNVGMPIAMML 759
G+N VV+GRS VG IA +L
Sbjct: 240 KVEGKNVVVLGRSNLVGRTIATIL 263
Score = 43.2 bits (97), Expect = 0.008
Identities = 26/81 (32%), Positives = 42/81 (51%), Gaps = 1/81 (1%)
Frame = +2
Query: 269 KKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR-DSDI 445
KK +K ++ P + I VGD +Y++ K + VG T++R SDI
Sbjct: 99 KKSIKADTEDFIKNSGVTPNLVVIYVGDSKQIESYIKAKRTGCEDVGFK-FTLDRFSSDI 157
Query: 446 TEEQLLSEIQNLNEDNNVDGI 508
E+QL+ +I+ +ED +V GI
Sbjct: 158 KEDQLIKKIKYHSEDPSVHGI 178
>UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Actinobacteridae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycobacterium sp. (strain JLS)
Length = 288
Score = 76.2 bits (179), Expect = 9e-13
Identities = 34/88 (38%), Positives = 52/88 (59%)
Frame = +1
Query: 496 C*WNFVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLK 675
C VQLP+P ++E + I P KD DG H N+GRL ++ P +P T +V +L+
Sbjct: 94 CTGYIVQLPLPKHLDENAALERIDPGKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLR 153
Query: 676 RFNIDTFGRNAVVIGRSKNVGMPIAMML 759
R+ ++ G + VVIGR VG P+ ++L
Sbjct: 154 RYEVEIAGAHVVVIGRGVTVGRPLGLLL 181
Score = 51.6 bits (118), Expect = 2e-05
Identities = 28/81 (34%), Positives = 45/81 (55%)
Frame = +2
Query: 263 EIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSD 442
EI +LK+++A G R P + ++VGDDP S YVR K VGI+++ + +D
Sbjct: 17 EIFVDLKERVAALTEQG-RTPGLGTVLVGDDPGSQAYVRGKHSDCAKVGINSIRRDLPAD 75
Query: 443 ITEEQLLSEIQNLNEDNNVDG 505
I++ +L + I LN + G
Sbjct: 76 ISQAELDATIDELNANPECTG 96
>UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Tropheryma whipplei|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 295
Score = 75.8 bits (178), Expect = 1e-12
Identities = 34/83 (40%), Positives = 52/83 (62%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P++I++ +V +AI P+KD DG H +N+G L IVP T +V++L+ I
Sbjct: 96 VQLPLPESIDQNKVIEAINPDKDADGLHPLNLGYLVTGKQGIVPCTPAGIVKLLEAHRIT 155
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G+ VIGR VG P+ ++L
Sbjct: 156 LEGKTIAVIGRGTTVGRPLGILL 178
Score = 49.2 bits (112), Expect = 1e-04
Identities = 21/62 (33%), Positives = 41/62 (66%)
Frame = +2
Query: 323 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNNVD 502
P + ++VG++PAS +YV +K K +GI + I ++ +E++L+S+++ LN ++V
Sbjct: 33 PKLATVLVGNNPASRSYVLSKHRDCKNIGIQSTLIELPANTSEKELISKVEILNASSDVS 92
Query: 503 GI 508
GI
Sbjct: 93 GI 94
>UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Proteobacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acinetobacter sp. (strain ADP1)
Length = 297
Score = 75.8 bits (178), Expect = 1e-12
Identities = 35/87 (40%), Positives = 59/87 (67%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
++IA + +E+K ++ ++ + G P + ++VG+DPAS YVRNKV+ A FVGI +L
Sbjct: 17 KAIAQSVLEEVKLEVERYKAQGIE-PCLAVVLVGEDPASQVYVRNKVQKAAFVGIRSLEF 75
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
D+D++E++LL++I LN + V GI
Sbjct: 76 RFDADLSEDELLTQIDRLNTERGVHGI 102
Score = 75.4 bits (177), Expect = 2e-12
Identities = 39/84 (46%), Positives = 50/84 (59%), Gaps = 1/84 (1%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLK-RFNI 687
VQLP+P INE RV + I P+KD+DGFH N+G L + P T + +LK
Sbjct: 104 VQLPLPKQINETRVLERIHPQKDVDGFHSENVGGLSQGRDVLTPCTPTGCIRLLKDSLGD 163
Query: 688 DTFGRNAVVIGRSKNVGMPIAMML 759
D G +AVVIGRS VG P+A +L
Sbjct: 164 DLSGLHAVVIGRSNIVGKPMAALL 187
>UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep:
PugilistDominant - Drosophila melanogaster (Fruit fly)
Length = 268
Score = 75.4 bits (177), Expect = 2e-12
Identities = 37/84 (44%), Positives = 56/84 (66%), Gaps = 3/84 (3%)
Frame = +1
Query: 511 VQLPVP-DT-INERRVCDAIAPEKDIDGFHIINIGRLCV-DLPTIVPATALAVVEMLKRF 681
VQ+P+ DT I+ R+ DA++PEKD+DG H +N GRL + DL +P T +E+++R
Sbjct: 99 VQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNEGRLAIGDLGGFLPCTPWGCLELIRRS 158
Query: 682 NIDTFGRNAVVIGRSKNVGMPIAM 753
++ G AVV+GRSK VG P ++
Sbjct: 159 GVEIAGARAVVLGRSKIVGTPASL 182
Score = 62.1 bits (144), Expect = 2e-08
Identities = 33/87 (37%), Positives = 52/87 (59%), Gaps = 1/87 (1%)
Frame = +2
Query: 251 SIAMEIKKELKQKI-AQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
++A I++EL+ ++ A L + P +R + VG S+ Y+R K++AA +GIDA +
Sbjct: 11 AVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEIGIDAAHV 70
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
ITE +LL +I +LNED V GI
Sbjct: 71 QLPRSITEVELLDKINDLNEDPRVHGI 97
>UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Enterobacteriaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Buchnera aphidicola subsp. Cinara cedri
Length = 284
Score = 75.4 bits (177), Expect = 2e-12
Identities = 35/83 (42%), Positives = 52/83 (62%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+QLP+P IN ++ +I P+KD+DGFH N+G LC + P T+ V+ +LK++ I+
Sbjct: 97 IQLPLPIKINYLKIITSIDPKKDVDGFHPYNLGSLCQNNPQFRSCTSKGVITLLKKYKIN 156
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G AV+IG S VG P+ M L
Sbjct: 157 IHGLYAVIIGSSNIVGKPMYMEL 179
Score = 52.0 bits (119), Expect = 2e-05
Identities = 27/85 (31%), Positives = 50/85 (58%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
I+ +I K++K+KI + + P + I++G++PAS YV K EA G ++ +
Sbjct: 11 ISKKIIKKIKKKIEKRKKKRKKIPGLAMIVIGNNPASLIYVNKKREACNQAGFFSIYWHL 70
Query: 434 DSDITEEQLLSEIQNLNEDNNVDGI 508
+ I E +L++ I+ LN++ +DGI
Sbjct: 71 SNQIEEIELINLIKKLNKNKCIDGI 95
>UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Rickettsia|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rickettsia prowazekii
Length = 286
Score = 74.5 bits (175), Expect = 3e-12
Identities = 33/84 (39%), Positives = 56/84 (66%), Gaps = 1/84 (1%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDL-PTIVPATALAVVEMLKRFNI 687
VQLP+P +I+E ++ A+ P KD DGFH +N+G L + +P TAL + ++K++
Sbjct: 97 VQLPLPSSIDENKILSAVLPSKDSDGFHPLNVGYLHSGINQGFIPCTALGCLAVIKKYAP 156
Query: 688 DTFGRNAVVIGRSKNVGMPIAMML 759
+ G++AV++GRS VG P++ +L
Sbjct: 157 NLNGKDAVIVGRSNIVGKPLSALL 180
Score = 66.1 bits (154), Expect = 9e-10
Identities = 32/87 (36%), Positives = 53/87 (60%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+++A EI +LK +I + +P + ++VGD+PAS YV+NK++ A VGID L +
Sbjct: 9 KALANEILADLKLEIQGFKEKTKTSPKLAIVLVGDNPASMIYVKNKIKNAHQVGIDTLLV 68
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
N ++I + L+ +I LN D + GI
Sbjct: 69 NLSTNIYTDDLILKINELNLDKGISGI 95
>UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Mollicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mesoplasma florum (Acholeplasma florum)
Length = 286
Score = 74.5 bits (175), Expect = 3e-12
Identities = 36/87 (41%), Positives = 56/87 (64%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+ +A K+EL KI+++ + G R P + I+VG+DPAS YV +K++ A VGI + +
Sbjct: 7 KKVASRRKEELTAKISKYHNKGLRKPKLVVIMVGNDPASEVYVSHKIKVANEVGIYSELL 66
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
D DI +E+L ++I LN D N+DGI
Sbjct: 67 RFDKDIKKEELYNKINELNNDQNIDGI 93
Score = 74.1 bits (174), Expect = 4e-12
Identities = 33/83 (39%), Positives = 48/83 (57%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+QLP+P E AI P KD+DGFH IN G++ T+ P T L ++ +L+ +NI
Sbjct: 95 LQLPLPIDFIEEDYLQAITPSKDVDGFHYINQGKMLQGYDTVYPCTPLGIINLLEEYNIS 154
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
++ +IG S VG P+ MML
Sbjct: 155 VKNKDITLIGTSNIVGKPLGMML 177
>UniRef50_UPI0000D9A063 Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Macaca mulatta|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Macaca mulatta
Length = 198
Score = 74.1 bits (174), Expect = 4e-12
Identities = 34/86 (39%), Positives = 55/86 (63%)
Frame = +1
Query: 505 NFVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFN 684
+ VQLP+ +ER++C+A +P+K +D F ++N+G C+D +++ AT V E +K+ +
Sbjct: 32 HLVQLPLAGHTDERKICNAFSPDKGVDDFPVMNVGLKCLDQYSMLLATRWDVRETIKQTD 91
Query: 685 IDTFGRNAVVIGRSKNVGMPIAMMLH 762
+ + VV GRSK V MPI M LH
Sbjct: 92 VPILEKTVVVAGRSKIVRMPIVMSLH 117
>UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Debaryomyces hansenii|Rep: Debaryomyces hansenii
chromosome E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 276
Score = 74.1 bits (174), Expect = 4e-12
Identities = 37/85 (43%), Positives = 51/85 (60%), Gaps = 2/85 (2%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLKRFN 684
+QLP+P NE + +A+A EKD+DGF N+G L P P T ++E++K
Sbjct: 139 IQLPLPKHFNETLITNAVATEKDVDGFARYNVGELTKKGGAPMFKPCTPNGIMELIKTTG 198
Query: 685 IDTFGRNAVVIGRSKNVGMPIAMML 759
I G+NAVV+GRS VG P+A ML
Sbjct: 199 ISLRGKNAVVLGRSDIVGTPVAAML 223
Score = 50.8 bits (116), Expect = 4e-05
Identities = 26/62 (41%), Positives = 37/62 (59%)
Frame = +2
Query: 323 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNNVD 502
P + I VG P S YV+ K++AAK I + + D D++EE LL EI LN+D V+
Sbjct: 76 PNLTIIQVGGRPDSSAYVKAKLKAAKSSNILSSLLKFDEDMSEEDLLEEIDRLNKDPKVN 135
Query: 503 GI 508
G+
Sbjct: 136 GL 137
>UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=36; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus sp. (strain CC9902)
Length = 293
Score = 74.1 bits (174), Expect = 4e-12
Identities = 40/89 (44%), Positives = 53/89 (59%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+QLP+P+ ++E + AI PEKD DG H +N+GRL T V+ ML+ ID
Sbjct: 96 LQLPLPEGLDEGPLLMAIDPEKDADGLHTLNLGRLLKGEQGPRSCTPAGVMAMLRSQGID 155
Query: 691 TFGRNAVVIGRSKNVGMPIAMMLHATRDT 777
G+ AVVIGRS VG P+A+ML A T
Sbjct: 156 PAGQRAVVIGRSILVGQPMALMLQAANAT 184
Score = 56.4 bits (130), Expect = 8e-07
Identities = 30/87 (34%), Positives = 47/87 (54%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+++A ++ L+ +I + R P + + VGDDPAS YV NK +A +G+ +
Sbjct: 8 KALAKAVESRLQAQIESNLPQAGRPPGLAVLRVGDDPASAVYVANKEKACARIGVASYGA 67
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+ S ++LS IQ LN D VDGI
Sbjct: 68 HLPSSTPFAEVLSTIQQLNADPRVDGI 94
>UniRef50_O84081 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Chlamydiaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Chlamydia trachomatis
Length = 287
Score = 74.1 bits (174), Expect = 4e-12
Identities = 31/84 (36%), Positives = 53/84 (63%), Gaps = 1/84 (1%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV-DLPTIVPATALAVVEMLKRFNI 687
VQLP+P ++ + + I P+KD+DG H +N+G+L + + +P T +VE+ K + I
Sbjct: 90 VQLPLPKHLDAQAILSTITPDKDVDGLHPVNVGKLLLGETDGFIPCTPAGIVELCKYYEI 149
Query: 688 DTFGRNAVVIGRSKNVGMPIAMML 759
G++ V++GRS VG P+A +L
Sbjct: 150 PLHGKHVVILGRSNIVGKPLAALL 173
Score = 51.2 bits (117), Expect = 3e-05
Identities = 22/65 (33%), Positives = 40/65 (61%)
Frame = +2
Query: 314 NRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDN 493
++AP + +++G++PAS YV K++ A +G+ + + + SD T +L+ I LN D
Sbjct: 24 SKAPGLAVVLIGNNPASEIYVNMKIKRATDLGMVSKSYRKPSDATLSDILALIHQLNNDE 83
Query: 494 NVDGI 508
N+ GI
Sbjct: 84 NIHGI 88
>UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelagibacter ubique
Length = 281
Score = 73.7 bits (173), Expect = 5e-12
Identities = 35/83 (42%), Positives = 52/83 (62%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P I++++V + I P KD+DGFH +N+G L + VP T L M+K+ +
Sbjct: 95 VQLPLPKHIDKQKVIETILPGKDVDGFHPMNVGNLSSGYESSVPCTPLGCYLMIKKIEPN 154
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G+ AV+IGRS G P+A +L
Sbjct: 155 LSGKKAVMIGRSNLNGKPMAQLL 177
Score = 59.7 bits (138), Expect = 8e-08
Identities = 27/87 (31%), Positives = 53/87 (60%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+ IA E++++L+Q++ + + N+ P + I++G+ S YVR K +AA VG+ + I
Sbjct: 7 KKIAAELREQLRQEVVELKAKHNKIPGLTVILIGEMAPSQIYVRMKEKAANEVGLKSEVI 66
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+ E+ +L +I+ LN+D ++ GI
Sbjct: 67 RYPEAVEEKTVLDKIEELNKDESISGI 93
>UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Firmicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus acidophilus
Length = 283
Score = 73.3 bits (172), Expect = 6e-12
Identities = 36/83 (43%), Positives = 52/83 (62%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP P+ I+ + + I P KD+DG NIGR+ ++ I PATA ++ +LK + I
Sbjct: 95 VQLPAPEQIDADELLERIDPNKDVDGLTPSNIGRIWMENHFIEPATAEGIIALLKYYKIL 154
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G+N VVIGRS VG P+A ++
Sbjct: 155 LKGKNVVVIGRSNIVGKPVAALM 177
Score = 48.0 bits (109), Expect = 3e-04
Identities = 29/85 (34%), Positives = 45/85 (52%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
+A + ++LK+K+ G P I +GDDPAS YVR K A+ +GI
Sbjct: 10 VANLLGEKLKEKVKDLKEEGI-TPHFCVINIGDDPASKIYVRTKKRRAEKMGIIQDIYQL 68
Query: 434 DSDITEEQLLSEIQNLNEDNNVDGI 508
+D +E L+ I LNED +++G+
Sbjct: 69 PADTKQEVALNLIDKLNEDPDINGV 93
>UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Frankia|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Frankia sp. (strain CcI3)
Length = 276
Score = 73.3 bits (172), Expect = 6e-12
Identities = 37/85 (43%), Positives = 51/85 (60%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQ P+P + R V + I KD+DG + ++GRL + LP+ PATA AVVE+L R I
Sbjct: 92 VQTPLPGGLTSREVGEHIPTAKDVDGMNPSSLGRLALGLPSFAPATAAAVVEILTRARIP 151
Query: 691 TFGRNAVVIGRSKNVGMPIAMMLHA 765
G VIGR VG P++++L A
Sbjct: 152 MSGARVCVIGRGPVVGKPVSLLLLA 176
>UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Halobacterium salinarium (Halobacterium
halobium)
Length = 297
Score = 72.5 bits (170), Expect = 1e-11
Identities = 35/83 (42%), Positives = 47/83 (56%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQ P PD + + RV A+ P KD+DGFH N+G+L P P T V ++L +D
Sbjct: 95 VQDPTPDHVPDERVLSAVDPAKDVDGFHPENVGKLVGGTPRFKPCTPHGVQKLLAHQGVD 154
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G VV+GRS VG P+A +L
Sbjct: 155 PDGAEVVVVGRSNIVGKPLANLL 177
Score = 38.7 bits (86), Expect = 0.16
Identities = 22/86 (25%), Positives = 42/86 (48%)
Frame = +2
Query: 251 SIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTIN 430
++A +++ +L + + G P + +++ D AS TYV K + + VGI A +
Sbjct: 9 AVAAQLRADLTGAVETLETAGV-TPRLATVLMNDKQASETYVSMKQQDCEEVGIAAEDVR 67
Query: 431 RDSDITEEQLLSEIQNLNEDNNVDGI 508
D + + + L + LN +V GI
Sbjct: 68 IDPEASADTLFDTVAELNAREDVHGI 93
>UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=82; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Caulobacter crescentus (Caulobacter
vibrioides)
Length = 297
Score = 72.5 bits (170), Expect = 1e-11
Identities = 36/85 (42%), Positives = 51/85 (60%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQ PVP I++ V A++P+KD+DG + N GRL LP + P T + +++ D
Sbjct: 98 VQFPVPPHISQMDVVAALSPDKDVDGLTVTNAGRLASGLPALAPCTPTGCMMLIRDAIGD 157
Query: 691 TFGRNAVVIGRSKNVGMPIAMMLHA 765
G+ AVVIGRS +G P+A ML A
Sbjct: 158 LKGKTAVVIGRSNLMGKPMAQMLLA 182
Score = 52.8 bits (121), Expect = 9e-06
Identities = 24/87 (27%), Positives = 48/87 (55%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
++ A +++ ++ +++A + P + ++VG+DPAS YVRNK E G+ + T
Sbjct: 10 KAFAADLRAKIAEEVAALKAEHGVTPGLAVVLVGEDPASQVYVRNKGEQTTAAGMYSETH 69
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
T+++LL+ + LN D + G+
Sbjct: 70 RLPETTTQDELLAVVAKLNADPKIHGV 96
>UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Actinomycetales|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhodococcus sp. (strain RHA1)
Length = 297
Score = 72.1 bits (169), Expect = 1e-11
Identities = 35/83 (42%), Positives = 50/83 (60%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+Q P+PD + + +AI P KD+DG + +++GRL LP PATA AV+ +L I
Sbjct: 95 LQTPLPDGTDLDALREAINPAKDVDGANPVSLGRLVARLPAFAPATAQAVIALLDHHGIS 154
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
R A V+GRS VG P+A +L
Sbjct: 155 PHARTATVVGRSTVVGSPVAHLL 177
Score = 37.1 bits (82), Expect = 0.50
Identities = 25/85 (29%), Positives = 40/85 (47%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
+A I+ + A LG R P + + DD ++ YVR+ AAK GI ++
Sbjct: 10 LATSIRNDASVAAAALNDLGTR-PKLAVVQATDDESTAWYVRSIASAAKRTGILCDIVDL 68
Query: 434 DSDITEEQLLSEIQNLNEDNNVDGI 508
+ + EQ+ S + L D +V GI
Sbjct: 69 GAAASTEQIRSTLVELGHDPDVHGI 93
>UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to
ENSANGP00000016878; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000016878 - Nasonia
vitripennis
Length = 866
Score = 70.9 bits (166), Expect = 3e-11
Identities = 34/86 (39%), Positives = 53/86 (61%), Gaps = 3/86 (3%)
Frame = +1
Query: 511 VQLPVPDT--INERRVCDAIAPEKDIDGFHIINIGRLCV-DLPTIVPATALAVVEMLKRF 681
VQ+P+ IN + D ++P+KD+DG + IN GR+ + D+ +P T +E++KR
Sbjct: 102 VQMPLDSVNKINSHLITDTVSPDKDVDGLNTINEGRVAIGDMSGFLPCTPNGCIELIKRS 161
Query: 682 NIDTFGRNAVVIGRSKNVGMPIAMML 759
+ G AVV+GRSK VG P+A +L
Sbjct: 162 GVPIAGAQAVVLGRSKIVGTPVAELL 187
Score = 53.6 bits (123), Expect = 5e-06
Identities = 29/86 (33%), Positives = 48/86 (55%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQ-WVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTIN 430
+A EI++ L + +A L N AP + + VG S+ Y+R K++AA +GI A +
Sbjct: 15 LAKEIRESLAKDVAAIQQKLPNYAPGLAIVQVGGREDSNVYIRMKIKAASEIGIKATHVK 74
Query: 431 RDSDITEEQLLSEIQNLNEDNNVDGI 508
+ TE +LL+++ LN D + GI
Sbjct: 75 MPNTTTEHELLTKLNKLNNDPDTHGI 100
>UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermoanaerobacter|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoanaerobacter tengcongensis
Length = 280
Score = 69.3 bits (162), Expect = 1e-10
Identities = 32/83 (38%), Positives = 50/83 (60%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+++P+P + +V D I P KD+D N+GRL P VP T A++ +L+ +D
Sbjct: 92 IEMPLPKGFDVDKVYDTINPYKDVDCISNYNMGRLFAGKPLFVPCTPKAIIHILENTGVD 151
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G++AVVIGRS +G P+A +L
Sbjct: 152 LEGKHAVVIGRSNILGKPVAKLL 174
Score = 49.2 bits (112), Expect = 1e-04
Identities = 24/82 (29%), Positives = 45/82 (54%)
Frame = +2
Query: 263 EIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSD 442
EI +K+++ + + P + ++ GDD +S Y +KV+A + VGI+A + S+
Sbjct: 10 EISNRIKEEVKREIQEFGYKPRLAILMAGDDESSKVYANSKVKACESVGIEA-KVYYFSE 68
Query: 443 ITEEQLLSEIQNLNEDNNVDGI 508
E++ ++ LNED + GI
Sbjct: 69 KEEDKFFDTLEKLNEDKDTHGI 90
>UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Methanosarcina acetivorans
Length = 290
Score = 69.3 bits (162), Expect = 1e-10
Identities = 33/86 (38%), Positives = 51/86 (59%), Gaps = 3/86 (3%)
Frame = +1
Query: 511 VQLPVPDTINERRV---CDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRF 681
+QLP+P + + +AI+P KD DGFH N+G+L + +VP T V+ L+ +
Sbjct: 102 LQLPLPKHFSPQETQEAMEAISPTKDADGFHPYNMGKLMIGDEDLVPCTPHGVIRALEEY 161
Query: 682 NIDTFGRNAVVIGRSKNVGMPIAMML 759
+ G+NAV++G S VG P+A ML
Sbjct: 162 GVSVQGKNAVIVGHSNVVGKPMAAML 187
Score = 57.2 bits (132), Expect = 4e-07
Identities = 31/85 (36%), Positives = 49/85 (57%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
+A ++++E++ + S P + I+VGDDPAS YVR K A + VGI A
Sbjct: 16 LAQQVEEEVRSGVEDLESNRGIVPGLATILVGDDPASKMYVRLKHRACERVGIKAEDYLL 75
Query: 434 DSDITEEQLLSEIQNLNEDNNVDGI 508
D T+E+LL+ I +LN++ +V I
Sbjct: 76 PGDATQEELLTLIDSLNKNKDVHAI 100
>UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Clostridium|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium acetobutylicum
Length = 278
Score = 69.3 bits (162), Expect = 1e-10
Identities = 33/83 (39%), Positives = 49/83 (59%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+QLP+P+ I+ + V I KDID IN G+ + +P T +++ ++K N+D
Sbjct: 96 LQLPLPNHIDAKLVTSKIDANKDIDSLTDINTGKFYKGEKSFIPCTPRSIINLIKSLNVD 155
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G+NAVVIGRS VG P A +L
Sbjct: 156 ICGKNAVVIGRSNIVGKPTAQLL 178
Score = 52.4 bits (120), Expect = 1e-05
Identities = 30/83 (36%), Positives = 47/83 (56%), Gaps = 4/83 (4%)
Frame = +2
Query: 272 KELKQKIAQWVS----LGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDS 439
++ K KI ++++ G P I I VGDD S YV N+ + ++ +GI+ +I D
Sbjct: 12 QKYKDKIIEFINERKKQGLDIPCIASITVGDDGGSLYYVNNQKKVSESLGIEFKSIFLDE 71
Query: 440 DITEEQLLSEIQNLNEDNNVDGI 508
I EE+L+ I+ LN DN + GI
Sbjct: 72 SIREEELIKLIEGLNVDNKIHGI 94
>UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Spiroplasma citri|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Spiroplasma citri
Length = 286
Score = 68.9 bits (161), Expect = 1e-10
Identities = 32/83 (38%), Positives = 51/83 (61%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P IN +V + I +KD+DGF +G L + ++P+T ++ +LK + I
Sbjct: 98 VQLPLPSHINSEKVINTIITKKDVDGFTPKILGNLMLGHYNLLPSTPKGIIALLKHYQIQ 157
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G++ V+IGRS VG P+A +L
Sbjct: 158 LAGQHVVIIGRSNIVGKPLANLL 180
Score = 52.8 bits (121), Expect = 9e-06
Identities = 26/81 (32%), Positives = 46/81 (56%)
Frame = +2
Query: 266 IKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDI 445
IK ++ ++I + + R P + I +G++ AS TY++NK A + VG+ +N I
Sbjct: 16 IKAKITEQILKIKAKKQRVPALTIIQIGNNKASTTYIKNKKIACEKVGVTCKVLNYPDII 75
Query: 446 TEEQLLSEIQNLNEDNNVDGI 508
TE L+ I +LN ++ +D I
Sbjct: 76 TESALIKIINDLNNNSKIDAI 96
>UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Peptococcaceae|Rep: Bifunctional protein folD 2
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Desulfitobacterium hafniense (strain Y51)
Length = 284
Score = 68.9 bits (161), Expect = 1e-10
Identities = 28/83 (33%), Positives = 52/83 (62%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
++LP+P I++ RV A+ P+KD+DG H IN G + + PAT + +E++ R ++
Sbjct: 95 IELPLPKHISKERVMAAVRPDKDVDGVHPINRGYILSGEEGLFPATPESCIEIMLRSGVE 154
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G++ V++GR + VG P+ ++
Sbjct: 155 IAGKHVVIVGRGETVGKPLVFLI 177
Score = 58.8 bits (136), Expect = 1e-07
Identities = 29/87 (33%), Positives = 53/87 (60%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+ I+ +K+E+K+++ +W G P + ++VGDDPAS Y ++K + + +GID
Sbjct: 8 KEISKVLKEEIKEEVKRWKEQGVN-PKLAVVLVGDDPASVVYAKSKQKVSDSLGIDFELT 66
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+D +EE +L+ I +LN + +V GI
Sbjct: 67 VLPADSSEESILALIDSLNANPDVHGI 93
>UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=5; Chloroflexi (class)|Rep:
Methylenetetrahydrofolate dehydrogenase (NADP(+)) -
Roseiflexus sp. RS-1
Length = 288
Score = 68.5 bits (160), Expect = 2e-10
Identities = 36/89 (40%), Positives = 52/89 (58%), Gaps = 3/89 (3%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+ LP+P ++ R I P KD+DG H N G L + P ++P T +E+L R NI
Sbjct: 97 LHLPLPPGLDSARAIAQIDPAKDVDGVHPYNAGLLAMGRPGLIPNTPAGGMELLLRNNIP 156
Query: 691 TFGRNAVVIGRSKNVGMPIAMML---HAT 768
G++A V+GRS VG P+A++L HAT
Sbjct: 157 LKGQHATVVGRSVVVGKPMALLLLNEHAT 185
Score = 37.5 bits (83), Expect = 0.37
Identities = 20/87 (22%), Positives = 40/87 (45%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+++A +++EL+ ++ AP++ + + DPAS Y R + + +GI
Sbjct: 9 RALAKTLREELRADTQAFIQNNGIAPSLAVVKIAGDPASDRYTRTIRKGCEEIGITFTDH 68
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+ T+ L I L+ D + GI
Sbjct: 69 TLPPETTQAMLEETISALSFDRTIHGI 95
>UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=11; Clostridiales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium difficile (strain 630)
Length = 290
Score = 68.5 bits (160), Expect = 2e-10
Identities = 38/87 (43%), Positives = 51/87 (58%), Gaps = 4/87 (4%)
Frame = +1
Query: 520 PVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV-DLPTIVPATALAVVEMLKRFNIDTF 696
P+P +NE + IAPEKD+D F IN ++ D P T AVVE+LK +N+D
Sbjct: 104 PLPKHLNEEVIKYVIAPEKDVDCFSPINSAKVMEGDKSGFPPCTPTAVVEILKHYNVDLK 163
Query: 697 GRNAVVIGRSKNVGMPIAMML---HAT 768
G V+GRS VG P++M+L HAT
Sbjct: 164 GSKVTVLGRSMVVGKPVSMLLLSEHAT 190
Score = 41.5 bits (93), Expect = 0.023
Identities = 24/93 (25%), Positives = 48/93 (51%)
Frame = +2
Query: 230 GAYPRWQSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 409
G + + +A +I +EL +++ V G P + + VG +Y R ++ + +G
Sbjct: 8 GQIIKGKPVADKISEELIKEVDLLVKEGIN-PKLTIVRVGARSDDLSYERGALKRCQNIG 66
Query: 410 IDALTINRDSDITEEQLLSEIQNLNEDNNVDGI 508
I + DIT+E+ + ++ +N+D NV+GI
Sbjct: 67 ITTEVLELAEDITQEEYIDVLKRVNDDKNVNGI 99
>UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]; n=86; cellular organisms|Rep:
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF
synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)] - Homo sapiens (Human)
Length = 935
Score = 68.5 bits (160), Expect = 2e-10
Identities = 40/87 (45%), Positives = 54/87 (62%), Gaps = 4/87 (4%)
Frame = +1
Query: 511 VQLPVP--DTINERRVCDAIAPEKDIDGFHIINIGRLC-VDL-PTIVPATALAVVEMLKR 678
VQLP+ ++IN V +AIAPEKD+DG IN GRL DL +P T +E++K
Sbjct: 99 VQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKE 158
Query: 679 FNIDTFGRNAVVIGRSKNVGMPIAMML 759
+ GR+AVV+GRSK VG P+ +L
Sbjct: 159 TGVPIAGRHAVVVGRSKIVGAPMHDLL 185
Score = 46.4 bits (105), Expect = 8e-04
Identities = 26/87 (29%), Positives = 47/87 (54%), Gaps = 1/87 (1%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVS-LGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALT 424
+ I+ +I+ LK ++ Q + P + + VG+ S+ Y+ K++AA+ +GI A
Sbjct: 10 KEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEIGIKATH 69
Query: 425 INRDSDITEEQLLSEIQNLNEDNNVDG 505
I TE +++ I +LNED+ V G
Sbjct: 70 IKLPRTTTESEVMKYITSLNEDSTVHG 96
>UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Thermosinus carboxydivorans Nor1|Rep:
Methenyltetrahydrofolate cyclohydrolase - Thermosinus
carboxydivorans Nor1
Length = 279
Score = 68.1 bits (159), Expect = 2e-10
Identities = 33/81 (40%), Positives = 48/81 (59%)
Frame = +1
Query: 517 LPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTF 696
+P+P + RV A+AP+KD+D H +N G + P T AV+ +L + ID
Sbjct: 97 MPLPPHLATDRVAAALAPDKDVDALHPLNAGLVATGKSRWAPCTPRAVMAILDYYQIDVS 156
Query: 697 GRNAVVIGRSKNVGMPIAMML 759
G++AVVIGRS VG P+A +L
Sbjct: 157 GKHAVVIGRSNVVGKPLAHLL 177
Score = 49.6 bits (113), Expect = 9e-05
Identities = 26/87 (29%), Positives = 51/87 (58%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+++A K ++K K+ ++ N + ++VG+D AS Y V+ A +G+ A+
Sbjct: 8 KAVAAAYKAKIKAKVDA-LAAQNITCGLAILLVGNDAASRIYADRLVKLATGLGVQAVVR 66
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+ +D TEE++L+ + LNED+++ GI
Sbjct: 67 HLPADATEEEVLALVCELNEDDHIHGI 93
>UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
Length = 290
Score = 68.1 bits (159), Expect = 2e-10
Identities = 30/83 (36%), Positives = 48/83 (57%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+Q P+P + + + PEKD DG H +N+GRL + P VP T + ML+ ++I
Sbjct: 96 IQYPLPKGFDFNEALNLMLPEKDADGLHPVNLGRLVLQEPGPVPCTPAGIRAMLQHYDIA 155
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G+ VVIGR +G P++++L
Sbjct: 156 IEGKEVVVIGRGPTLGRPLSLLL 178
Score = 43.6 bits (98), Expect = 0.006
Identities = 25/89 (28%), Positives = 46/89 (51%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
+A + +++ +++A G +P + I+VGDD S +YV K E K VGI +
Sbjct: 11 VAAAVLEDVARRVAVLKDKGI-SPGLGTILVGDDGPSVSYVNKKRETCKQVGIASFHNEI 69
Query: 434 DSDITEEQLLSEIQNLNEDNNVDGISSNY 520
+ T+ LL+ +++ N+ +VD Y
Sbjct: 70 PASATQSDLLAAVRDFNDSPDVDAYIIQY 98
>UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 272
Score = 67.7 bits (158), Expect = 3e-10
Identities = 33/89 (37%), Positives = 52/89 (58%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+Q P+P ++N + +AI +KD++G H N+G+L + P T AV+ MLK +I
Sbjct: 88 LQTPLPASLNASHLVNAIDFDKDVEGIHNYNLGKLISKEEGVRPCTPKAVISMLKAHDIL 147
Query: 691 TFGRNAVVIGRSKNVGMPIAMMLHATRDT 777
G+ +IGRS VG P+A+M+ A T
Sbjct: 148 IEGQKVTIIGRSMTVGSPLALMMTAENAT 176
Score = 45.2 bits (102), Expect = 0.002
Identities = 25/82 (30%), Positives = 44/82 (53%)
Frame = +2
Query: 263 EIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSD 442
+I++++K+++ Q S + I VGDDP+S YVR + A+ G+ +N
Sbjct: 7 DIREQIKERVRQ--SAEEVKMGLAIIRVGDDPSSMAYVRGIRKFAEETGVKVEIVNLPDA 64
Query: 443 ITEEQLLSEIQNLNEDNNVDGI 508
+ E +LL I +LN + + GI
Sbjct: 65 VGERELLKTIGDLNNSSEITGI 86
>UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Bdellovibrio bacteriovorus|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Bdellovibrio
bacteriovorus
Length = 288
Score = 67.3 bits (157), Expect = 4e-10
Identities = 31/87 (35%), Positives = 51/87 (58%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+ +A E++ L ++A++ RAP + +IVGDD ASH YV+NK A + +G+ +
Sbjct: 8 KEVAKEVRASLVPRVAKFKETYGRAPQLSVVIVGDDKASHVYVKNKKIACEKIGMTSTIH 67
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
++ T+ +L + LN DN VDGI
Sbjct: 68 TLPAETTQSELNQILSKLNNDNGVDGI 94
Score = 65.7 bits (153), Expect = 1e-09
Identities = 31/83 (37%), Positives = 47/83 (56%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQ P+P ++ V ++ EKD DG ++G P + P T V+E+LK + I
Sbjct: 96 VQFPLPKHLSSDEVLKLVSAEKDADGLTYESLGYFFAGKPLVSPCTPAGVMEILKHYRIP 155
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G+ AVV+GRS VG P+A++L
Sbjct: 156 VEGKKAVVVGRSNIVGKPMALLL 178
>UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Proteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Ehrlichia canis (strain Jake)
Length = 300
Score = 66.9 bits (156), Expect = 5e-10
Identities = 35/85 (41%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLP--TIVPATALAVVEMLKRFN 684
VQLPVP I++ + + I P KD+DGFH N+GRL ++P T + ++K
Sbjct: 97 VQLPVPKHIDKNLIINTIDPRKDVDGFHNDNVGRLFTGQKRNCLIPCTPRGCLYLIKTVT 156
Query: 685 IDTFGRNAVVIGRSKNVGMPIAMML 759
+ G +AVVIGRS VG P+A +L
Sbjct: 157 HNLSGSDAVVIGRSNIVGKPMACLL 181
Score = 62.5 bits (145), Expect = 1e-08
Identities = 29/62 (46%), Positives = 40/62 (64%)
Frame = +2
Query: 323 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNNVD 502
P + ++VGDDPASH YVRNK A+ +G+ + TI S +E L+ +I LN D+NV
Sbjct: 34 PCLIVVLVGDDPASHLYVRNKQRKAEMLGLRSETILLPSTTSESSLIDKIHELNNDDNVH 93
Query: 503 GI 508
GI
Sbjct: 94 GI 95
>UniRef50_UPI000038C811 Cluster: COG0190:
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl
tetrahydrofolate cyclohydrolase; n=1; Nostoc punctiforme
PCC 73102|Rep: COG0190: 5,10-methylene-tetrahydrofolate
dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase -
Nostoc punctiforme PCC 73102
Length = 292
Score = 66.5 bits (155), Expect = 7e-10
Identities = 34/83 (40%), Positives = 50/83 (60%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+PD ++ + I P+KD DG H +N+GRL + T V+ +L+ + I
Sbjct: 100 VQLPLPDHLDAVALLHQIDPDKDADGLHPVNLGRLVRGEIGLRSCTPDGVMRLLQEYEIP 159
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G+ AVV+GRS VG P+A+ML
Sbjct: 160 LQGKQAVVVGRSILVGKPMALML 182
Score = 58.8 bits (136), Expect = 1e-07
Identities = 34/87 (39%), Positives = 50/87 (57%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
++IA +I++EL I Q R P + ++VGD+PAS YVRNK +A VGI +
Sbjct: 12 KAIAAKIQQELSVAITQLQPEIGRPPGLAVLMVGDNPASAAYVRNKEKACAKVGIASFGK 71
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+ ++ T +L I LN+D VDGI
Sbjct: 72 HFPAETTFRELEKVIAALNDDERVDGI 98
>UniRef50_O51057 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Borrelia burgdorferi group|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Borrelia burgdorferi
(Lyme disease spirochete)
Length = 308
Score = 66.5 bits (155), Expect = 7e-10
Identities = 32/84 (38%), Positives = 54/84 (64%), Gaps = 1/84 (1%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV-DLPTIVPATALAVVEMLKRFNI 687
VQLP+ ++ + ++I KD+DG +N+G++ + D +P TALAV+++L+ I
Sbjct: 101 VQLPLLKGMDLNSILNSIVYSKDVDGLSFVNLGKMILGDKKGFIPCTALAVLKILRDEGI 160
Query: 688 DTFGRNAVVIGRSKNVGMPIAMML 759
T G+ VV+GRS VG PI+++L
Sbjct: 161 KTLGKTVVVVGRSPLVGRPISILL 184
>UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Alphaproteobacteria|Rep: Bifunctional protein folD
2 [Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhizobium loti (Mesorhizobium loti)
Length = 306
Score = 66.5 bits (155), Expect = 7e-10
Identities = 33/83 (39%), Positives = 49/83 (59%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+Q PVP I+ + + A+ P KD++G H +IG + + + P TA A VE+LK +D
Sbjct: 100 IQRPVPAHISVKTLQAAVHPLKDVEGMHPASIGNIVYNQLDLAPCTAAASVELLKETGLD 159
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G VV+G S+ VG PIA +L
Sbjct: 160 LKGLEVVVVGHSEIVGKPIAFLL 182
Score = 39.5 bits (88), Expect = 0.093
Identities = 24/62 (38%), Positives = 30/62 (48%)
Frame = +2
Query: 323 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNNVD 502
P + I VGD A YVRN+ A+ GID + IT +L + I LN D V
Sbjct: 37 PKLISITVGDTDAVDVYVRNQRAKAQLAGIDFEERRFPATITSGELEAAIHGLNADPRVT 96
Query: 503 GI 508
GI
Sbjct: 97 GI 98
>UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 277
Score = 66.5 bits (155), Expect = 7e-10
Identities = 31/85 (36%), Positives = 55/85 (64%), Gaps = 2/85 (2%)
Frame = +1
Query: 511 VQLPVPDTINER--RVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFN 684
+QLP+P + E+ + AI P+KD+DGF ++N GR+ D P + ALA +E+++RF
Sbjct: 91 LQLPLPAALEEQTDEILAAIRPDKDVDGFSLVNRGRMSGDRPGFISCAALACLEVIERFF 150
Query: 685 IDTFGRNAVVIGRSKNVGMPIAMML 759
G+ AV++G S ++ +P+A ++
Sbjct: 151 PSLAGKKAVLVGDSFDLIIPLATIM 175
Score = 46.4 bits (105), Expect = 8e-04
Identities = 24/82 (29%), Positives = 45/82 (54%)
Frame = +2
Query: 263 EIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSD 442
+I +E++QK+ + +P + I+VG YV K +AA G + ++ D
Sbjct: 8 QIAQEIRQKLKEKNEREGISPCLAMILVGGQKEDLHYVGLKEKAATATGGKSRLLHLPED 67
Query: 443 ITEEQLLSEIQNLNEDNNVDGI 508
++++L+++I LN+D VDGI
Sbjct: 68 TSQQELMAKIAELNQDEQVDGI 89
>UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1; n=11; Viridiplantae|Rep:
Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1 - Zea mays (Maize)
Length = 160
Score = 66.1 bits (154), Expect = 9e-10
Identities = 30/65 (46%), Positives = 44/65 (67%), Gaps = 2/65 (3%)
Frame = +1
Query: 571 EKDIDGFHIINIGRLCVD--LPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMP 744
EKD+DGFH +NIG+L + P +P T +E+L R I G+NAVV+GRS VG+P
Sbjct: 1 EKDVDGFHPLNIGKLAMKGRQPLFLPCTPKGCIELLHRSGISIKGKNAVVVGRSNIVGLP 60
Query: 745 IAMML 759
++++L
Sbjct: 61 VSLLL 65
>UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Prochlorococcus marinus|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Prochlorococcus marinus subsp. pastoris
(strain CCMP 1378 / MED4)
Length = 298
Score = 66.1 bits (154), Expect = 9e-10
Identities = 33/83 (39%), Positives = 50/83 (60%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+QLP+ +E+R+ I PEKD+DG + NIG+L + + T +V +LK NI
Sbjct: 96 LQLPISKKFDEQRLISFINPEKDVDGLNEQNIGKLVKNEQAMRSCTPAGIVNLLKSQNIK 155
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G+ VVIGRS VG P+++M+
Sbjct: 156 IEGKKIVVIGRSLLVGKPLSLMM 178
Score = 57.6 bits (133), Expect = 3e-07
Identities = 27/87 (31%), Positives = 50/87 (57%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+ +++EI++ L+ I ++ R P + I +G+DPAS YV NK +A VGI +
Sbjct: 8 KKLSLEIEERLRNYILTNKTIAKRNPGLAVIRIGEDPASGVYVGNKEKACSRVGIKSYIF 67
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
+ + ++++ + LN DNN+DG+
Sbjct: 68 HLKDTVEQKEVEQLLNKLNLDNNIDGM 94
>UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147,
whole genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_147,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 404
Score = 65.3 bits (152), Expect = 2e-09
Identities = 31/91 (34%), Positives = 57/91 (62%), Gaps = 2/91 (2%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV--DLPTIVPATALAVVEMLKRFN 684
VQLP+P +N+ + +I EKD+D H+ N+ R+ V +L ++P T AV+++L ++
Sbjct: 200 VQLPLPSHLNKLDIIHSIPYEKDVDCLHMHNLQRILVYGELCEMLPCTPAAVLQILDYYD 259
Query: 685 IDTFGRNAVVIGRSKNVGMPIAMMLHATRDT 777
++ G+ +IGRS VG+P++++L T
Sbjct: 260 VNVIGKKVTMIGRSFLVGLPLSLLLQKRNAT 290
Score = 50.8 bits (116), Expect = 4e-05
Identities = 21/56 (37%), Positives = 34/56 (60%)
Frame = +2
Query: 323 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNED 490
P + +VGD PAS +YV K++A + + +DA N ++ +EQL+ IQ +N D
Sbjct: 141 PKLGICLVGDSPASKSYVNRKLKACQEINVDAEVFNFSENVGQEQLIKHIQQMNHD 196
>UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Pyrobaculum|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pyrobaculum aerophilum
Length = 311
Score = 65.3 bits (152), Expect = 2e-09
Identities = 30/86 (34%), Positives = 52/86 (60%), Gaps = 3/86 (3%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPT---IVPATALAVVEMLKRF 681
+Q P+P ++E+ + A++PEKD+D N RL D ++P T ++E+ K +
Sbjct: 102 IQKPLPPFVDEKALFSALSPEKDVDALTPENKKRLLTDFDLDRDVLPCTPAGILELFKLY 161
Query: 682 NIDTFGRNAVVIGRSKNVGMPIAMML 759
ID G++ VV+G+ + VG P+A+ML
Sbjct: 162 GIDVRGKDVVVVGKGELVGKPLAVML 187
>UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=24; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Psychrobacter arcticum
Length = 295
Score = 65.3 bits (152), Expect = 2e-09
Identities = 31/87 (35%), Positives = 55/87 (63%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+++A +I+++L ++ + R P++ I+VGDDPAS TYVR K A + VG+D++ +
Sbjct: 20 KALAKQIEQQLSTRVDAIKAKTGRTPSLATILVGDDPASATYVRMKGNACQRVGMDSIRV 79
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
S T +L+++I LN + +V GI
Sbjct: 80 EMPSATTTAELMAKIDELNNNPDVHGI 106
Score = 60.5 bits (140), Expect = 5e-08
Identities = 31/83 (37%), Positives = 46/83 (55%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+Q PVP I+ER + I KD+DG + GR+ + T ++ +L+ NI+
Sbjct: 108 LQHPVPAHIDERACFEQIDLAKDVDGVTCLGFGRMAMQQSAYGSCTPQGIMHLLEHHNIE 167
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G AVV+GRS +G P+AMML
Sbjct: 168 LAGLEAVVVGRSAILGKPMAMML 190
>UniRef50_UPI0000D9D4E1 Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=2; Catarrhini|Rep: PREDICTED:
similar to Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor -
Macaca mulatta
Length = 111
Score = 64.5 bits (150), Expect = 3e-09
Identities = 26/55 (47%), Positives = 42/55 (76%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 412
+ +A EIK+E++Q++ +WV+ GN+ P + I+VG++PASH+YV NK AA VG+
Sbjct: 43 RKLAQEIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAADVGM 97
>UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Methylenetetrahydrofolate dehydrogenase
(NADP(+)) - Candidatus Nitrosopumilus maritimus SCM1
Length = 287
Score = 64.1 bits (149), Expect = 4e-09
Identities = 34/85 (40%), Positives = 50/85 (58%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
I+ +K +K+ + + + G P + ++VGD+PAS TYVRNK A + VGI
Sbjct: 11 ISQSVKDRVKKAVEELKNQGIN-PCLATVLVGDNPASATYVRNKHRACEEVGITTKDHKL 69
Query: 434 DSDITEEQLLSEIQNLNEDNNVDGI 508
D+ T+ QL I+NLN DN+V GI
Sbjct: 70 DASTTQAQLNEIIENLNNDNSVHGI 94
Score = 58.8 bits (136), Expect = 1e-07
Identities = 31/83 (37%), Positives = 45/83 (54%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P+ ++E I+P KD+DG N G L + +V T V+EM I+
Sbjct: 96 VQLPLPEQLDEFTTTSRISPLKDVDGLTPHNAGLLAMKKAALVACTPSGVMEMFDYHGIE 155
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G+N V+I RS VG P+ +L
Sbjct: 156 LEGKNIVLINRSNLVGKPLYHLL 178
>UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Fusobacterium nucleatum|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Fusobacterium nucleatum subsp. nucleatum
Length = 283
Score = 64.1 bits (149), Expect = 4e-09
Identities = 32/90 (35%), Positives = 54/90 (60%), Gaps = 1/90 (1%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIV-PATALAVVEMLKRFNI 687
+ LP+P IN +V ++I KD+DGF N+G L + P+T ++ +++++NI
Sbjct: 94 INLPLPPQINATKVLNSIKLIKDVDGFKAENLGLLFQNNEGFTSPSTPAGIMALIEKYNI 153
Query: 688 DTFGRNAVVIGRSKNVGMPIAMMLHATRDT 777
D G++ VV+G S VG PIA ++ +R T
Sbjct: 154 DLEGKDVVVVGSSNIVGKPIAALILNSRGT 183
Score = 61.7 bits (143), Expect = 2e-08
Identities = 32/90 (35%), Positives = 52/90 (57%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+ +A +IK ++K +I + N P + I+VGDDPAS Y+ ++V++ + +GI
Sbjct: 6 KELARDIKVKIKAEIDNIKKIHNINPMVATILVGDDPASQVYLNSQVKSYQDLGIGVQKY 65
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGISSN 517
+I+E LL+ I LN+D VDGI N
Sbjct: 66 FFSEEISEAYLLNLIDKLNKDTEVDGIMIN 95
>UniRef50_A6LP88 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase; n=1; Thermosipho
melanesiensis BI429|Rep: Tetrahydrofolate
dehydrogenase/cyclohydrolase - Thermosipho melanesiensis
BI429
Length = 271
Score = 62.5 bits (145), Expect = 1e-08
Identities = 33/84 (39%), Positives = 48/84 (57%)
Frame = +1
Query: 508 FVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNI 687
FV P+ +NE + + + P KDI+G H N+G L P TA AVV +++ I
Sbjct: 86 FVTHPLSQ-VNEMEIFENLVPSKDIEGRHPYNLGMLAYGEEFFAPCTAEAVVRIMEN-EI 143
Query: 688 DTFGRNAVVIGRSKNVGMPIAMML 759
G+N V++GRS VG P+A+ML
Sbjct: 144 GIPGKNVVIVGRSNTVGKPLAIML 167
Score = 36.7 bits (81), Expect = 0.65
Identities = 21/79 (26%), Positives = 44/79 (55%)
Frame = +2
Query: 272 KELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITE 451
+++K + + + R P + + DP++ +Y++++ +AAK G+D +S
Sbjct: 10 EDIKVNLLKRIEKLKRTPKLVAVTFKPDPSTVSYLKSQEKAAKRFGLDYEIFEGNSPKGV 69
Query: 452 EQLLSEIQNLNEDNNVDGI 508
++L+E L+ DNNV+GI
Sbjct: 70 LKILAE---LSRDNNVNGI 85
>UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycoplasma
agalactiae|Rep: FolD bifunctional protein - Mycoplasma
agalactiae
Length = 286
Score = 62.1 bits (144), Expect = 2e-08
Identities = 33/85 (38%), Positives = 51/85 (60%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
IA E ELK++ + L R P + I VGD+PAS Y++NK++ A+ +G+ A
Sbjct: 9 IAEERTVELKKEFEEITKLIGRQPVLSIIQVGDNPASSLYIKNKIKKAEELGVKATLYKF 68
Query: 434 DSDITEEQLLSEIQNLNEDNNVDGI 508
D DI++ LL ++ LNE++ DGI
Sbjct: 69 DEDISQNSLLKKLDVLNEES--DGI 91
Score = 60.9 bits (141), Expect = 4e-08
Identities = 33/86 (38%), Positives = 49/86 (56%), Gaps = 3/86 (3%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGF---HIINIGRLCVDLPTIVPATALAVVEMLKRF 681
VQLP+P+ I+ + + + I EKD+DG N D + PATA A+++++ +
Sbjct: 93 VQLPLPEHISPKVIMNGIRLEKDVDGLCEKSTFNFYNDKYDELSFTPATAAAIIDLINYY 152
Query: 682 NIDTFGRNAVVIGRSKNVGMPIAMML 759
ID G+ A VIGRS VG P A +L
Sbjct: 153 KIDLNGKKAAVIGRSYLVGKPTAFLL 178
>UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=51; Actinobacteria (class)|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Arthrobacter sp. (strain FB24)
Length = 302
Score = 62.1 bits (144), Expect = 2e-08
Identities = 31/92 (33%), Positives = 51/92 (55%), Gaps = 4/92 (4%)
Frame = +1
Query: 496 C*WNFVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV----DLPTIVPATALAVV 663
C VQLP+P ++ + + I P KD DG H N+GRL + ++ + +P T V+
Sbjct: 93 CHGYIVQLPLPKHLDTDAILERIDPAKDADGLHPTNLGRLVLNVSGEITSPLPCTPRGVI 152
Query: 664 EMLKRFNIDTFGRNAVVIGRSKNVGMPIAMML 759
E+L+R G++ VV+GR +G I ++L
Sbjct: 153 ELLERNGYSLSGKHVVVVGRGVTIGRTIGLLL 184
Score = 46.0 bits (104), Expect = 0.001
Identities = 26/81 (32%), Positives = 46/81 (56%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
++ A IK EL +++A+ + G P I ++VG DPAS YV K + + +G++++
Sbjct: 11 KAAAAAIKSELAERVAKLKARGV-TPGIATVLVGADPASQLYVSMKHKQSVEIGMNSIQR 69
Query: 428 NRDSDITEEQLLSEIQNLNED 490
+D T+ Q+ + I LN D
Sbjct: 70 ELPADATQAQVEALIDELNAD 90
>UniRef50_A4M873 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase; n=1; Petrotoga mobilis
SJ95|Rep: Tetrahydrofolate dehydrogenase/cyclohydrolase
- Petrotoga mobilis SJ95
Length = 273
Score = 61.7 bits (143), Expect = 2e-08
Identities = 32/84 (38%), Positives = 48/84 (57%)
Frame = +1
Query: 508 FVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNI 687
F+ P+ E + I PEKD++G + NIG + + VP TA AVV++++
Sbjct: 83 FIARPLKKGYTELDIAKYINPEKDVEGVSLHNIGSMFYEKELFVPCTAEAVVKIIED-TT 141
Query: 688 DTFGRNAVVIGRSKNVGMPIAMML 759
D G+N V++GRS VG P A+ML
Sbjct: 142 DVRGKNIVILGRSTTVGKPAAIML 165
>UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermotogaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermotoga maritima
Length = 271
Score = 61.3 bits (142), Expect = 3e-08
Identities = 31/84 (36%), Positives = 48/84 (57%)
Frame = +1
Query: 508 FVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNI 687
FV P P ++E+ + ++ EKD++G + N+G L D P TA A V +L+R
Sbjct: 85 FVARPFPLGLDEKEILSSVPVEKDVEGVNPANLGLLLYDEEIFPPCTAEAAVRILER-ET 143
Query: 688 DTFGRNAVVIGRSKNVGMPIAMML 759
+ G+ V+GRS VG P+A+ML
Sbjct: 144 NLSGKRVTVVGRSVTVGKPLALML 167
>UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121;
n=5; Eutheria|Rep: Uncharacterized protein
ENSP00000372121 - Homo sapiens (Human)
Length = 200
Score = 59.7 bits (138), Expect = 8e-08
Identities = 24/57 (42%), Positives = 42/57 (73%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDA 418
+ +A +IK+E++Q++ +WV+ G++ P + I+VG+ ASH+YV NK AA VGI++
Sbjct: 43 RKLAQQIKQEVRQEVEEWVASGDKRPHLSMILVGESSASHSYVLNKTRAAADVGINS 99
>UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Orientia tsutsugamushi Boryong|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Orientia tsutsugamushi
(strain Boryong) (Rickettsia tsutsugamushi)
Length = 301
Score = 59.7 bits (138), Expect = 8e-08
Identities = 31/84 (36%), Positives = 51/84 (60%), Gaps = 1/84 (1%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPT-IVPATALAVVEMLKRFNI 687
VQLP+P I+ ++ I KD+DG + INIG L + ++P TAL +++L+ +
Sbjct: 96 VQLPLPPHIDALKLFARIDSRKDVDGLNPINIGYLNIGANQGLIPCTALGCIDLLQYYVT 155
Query: 688 DTFGRNAVVIGRSKNVGMPIAMML 759
G++ VVIG+S VG P++ +L
Sbjct: 156 GLKGKHVVVIGKSNIVGKPLSALL 179
Score = 47.6 bits (108), Expect = 4e-04
Identities = 26/57 (45%), Positives = 36/57 (63%)
Frame = +2
Query: 338 IIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNNVDGI 508
I+VG++ AS YV NKV AK +G+D+ I I E++L S I +LN D+ V GI
Sbjct: 38 ILVGNNDASLIYVNNKVAKAKAIGMDSEIIRLFEFIEEKKLFSVIDDLNCDSTVHGI 94
>UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillus
sp. NRRL B-14911|Rep: Bifunctional protein FolD -
Bacillus sp. NRRL B-14911
Length = 322
Score = 58.8 bits (136), Expect = 1e-07
Identities = 31/85 (36%), Positives = 48/85 (56%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
+A ++K+ L ++ G P + I+VGDDP+S TYVR K A +GI + I+
Sbjct: 51 VAADVKEGLMPRVENLTQKGI-TPCLATILVGDDPSSETYVRMKGNACARLGIRSERIHM 109
Query: 434 DSDITEEQLLSEIQNLNEDNNVDGI 508
+ T E+L+ I+ LNE+ V GI
Sbjct: 110 PKETTTEELVKTIEELNENKEVHGI 134
Score = 56.4 bits (130), Expect = 8e-07
Identities = 26/83 (31%), Positives = 49/83 (59%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+Q PVP I+ER+ + I+ +KD+DG G+ + T T A++ ++ +++
Sbjct: 136 LQHPVPGHIDERKAFETISIDKDVDGVTSHGYGQTALGFGTYPSCTPAAIMAIIDYYHLP 195
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G++AVV+GRS +G P++ +L
Sbjct: 196 VEGKHAVVVGRSPILGKPVSALL 218
>UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Leuconostocaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Oenococcus oeni (strain BAA-331 / PSU-1)
Length = 285
Score = 58.8 bits (136), Expect = 1e-07
Identities = 32/85 (37%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPT--IVPATALAVVEMLKRFN 684
VQ P+ D I+E ++ +AI P KD DG N G L + IVPAT V+ +L+ ++
Sbjct: 92 VQSPLGDGIDESKIFNAIDPLKDADGLSAFNQGLLFENAKENYIVPATPAGVISLLEAYH 151
Query: 685 IDTFGRNAVVIGRSKNVGMPIAMML 759
+NA+V+GRS G P++++L
Sbjct: 152 YQFAAKNALVVGRSVLFGRPMSVLL 176
>UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_57,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 309
Score = 58.4 bits (135), Expect = 2e-07
Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 2/85 (2%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPT--IVPATALAVVEMLKRFN 684
VQLP+P ++ + + I KDID H+ N L + I+P T AV+ +L N
Sbjct: 100 VQLPLPPHLSRLEISNEIKLNKDIDCLHMANFQNLLQNGEDNDIIPCTPAAVLHILDTQN 159
Query: 685 IDTFGRNAVVIGRSKNVGMPIAMML 759
ID +N VIGRS+ VG P++++L
Sbjct: 160 IDVRNQNVTVIGRSQLVGFPLSVLL 184
Score = 39.5 bits (88), Expect = 0.093
Identities = 19/62 (30%), Positives = 37/62 (59%)
Frame = +2
Query: 323 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNNVD 502
P + I VG++P+S TYVR K+ + I + I++++++ I++LN+ ++D
Sbjct: 37 PGLAIIQVGNNPSSLTYVRKKIALCEEHQIHHELYHFPETISQKEIVHRIKSLNQKGSID 96
Query: 503 GI 508
GI
Sbjct: 97 GI 98
>UniRef50_UPI00015563B5 Cluster: PREDICTED: similar to Mthfd2-prov
protein, partial; n=1; Ornithorhynchus anatinus|Rep:
PREDICTED: similar to Mthfd2-prov protein, partial -
Ornithorhynchus anatinus
Length = 161
Score = 57.2 bits (132), Expect = 4e-07
Identities = 21/50 (42%), Positives = 39/50 (78%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAA 397
+ +A +I++E++ ++ +WV+ GN+ P + I+VG++PASH+YV NK +AA
Sbjct: 53 RKLARQIREEVRHEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTKAA 102
>UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Lactobacillus|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus johnsonii
Length = 283
Score = 57.2 bits (132), Expect = 4e-07
Identities = 29/85 (34%), Positives = 49/85 (57%), Gaps = 2/85 (2%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVP--ATALAVVEMLKRFN 684
+QLP+P +N+ + +AIAPEKD+DGF+ N+G+L + P T+ ++ +L +
Sbjct: 95 IQLPLPKHLNQTELIEAIAPEKDVDGFNSKNVGKLYNNEEGHYPVSCTSRGIMTLLHTYL 154
Query: 685 IDTFGRNAVVIGRSKNVGMPIAMML 759
G N ++GRS V P+ +L
Sbjct: 155 DKIEGLNVTIVGRSILVSRPLQSLL 179
Score = 50.8 bits (116), Expect = 4e-05
Identities = 27/87 (31%), Positives = 49/87 (56%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+ IA ++ +E K ++ + G P I I+VGDDPAS Y RNK + A+ +G+ ++
Sbjct: 8 RQIAKQLNQETKTRVDKLKEEGI-IPGIVVILVGDDPASVIYTRNKQKNAEKLGMKSILR 66
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGI 508
D+++ ++L I + N+D + I
Sbjct: 67 KFPKDVSQAEVLQAIHHYNDDPTIHAI 93
>UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoplasma volcanium
Length = 281
Score = 56.8 bits (131), Expect = 6e-07
Identities = 30/83 (36%), Positives = 49/83 (59%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
V+ P+P TI+ + +I KD+D N G + ++ +VPATA+AVV++LK + +
Sbjct: 92 VENPLPKTIDYYDIVKSIPYYKDVDALSPYNQGSIAINREFLVPATAMAVVDILKYYGYE 151
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
A +I RS VG P++MM+
Sbjct: 152 K--TTATIINRSPVVGRPLSMMM 172
>UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whole
genome shotgun sequence; n=6; Clupeocephala|Rep:
Chromosome undetermined SCAF10300, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 348
Score = 56.0 bits (129), Expect = 1e-06
Identities = 36/96 (37%), Positives = 54/96 (56%), Gaps = 7/96 (7%)
Frame = +1
Query: 511 VQLPVPDT--INERRVCDAIAPEKDIDGFHIINIGRLCV-DLPT-IVPATALAVVEMLKR 678
VQLP+ I+ + + ++ +KD+DG IN GRL DL +P T +E++++
Sbjct: 145 VQLPLDSVHHIDSECITNTVSADKDVDGLSCINAGRLSRGDLDACFLPCTPSGCLELIRQ 204
Query: 679 FNIDTFGRNAVVIGRSKNVGMPIAMML---HATRDT 777
+ G+ AVVIGRSK VG P+ +L HAT T
Sbjct: 205 TGVSLEGKQAVVIGRSKIVGAPMHDLLLWNHATVTT 240
Score = 46.8 bits (106), Expect = 6e-04
Identities = 22/55 (40%), Positives = 35/55 (63%)
Frame = +2
Query: 344 VGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNNVDGI 508
VGD S+ Y+ K++AA +GIDA + S T+E++L I ++NED +V G+
Sbjct: 89 VGDRDDSNLYISAKMKAAAEIGIDAKHVRLPSSATQEEVLLNILSINEDQSVHGL 143
>UniRef50_Q6L046 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasmatales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Picrophilus torridus
Length = 276
Score = 56.0 bits (129), Expect = 1e-06
Identities = 35/83 (42%), Positives = 47/83 (56%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
++ PVP IN V + I KD+DG N+G L + I PATA AVV++L NI
Sbjct: 92 IETPVPG-INYYDVVNEIPFYKDVDGMTSYNLGNLYLKNEFIAPATARAVVDILDYINIK 150
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
+ N +I RS VG P++MML
Sbjct: 151 S--GNVAIINRSPVVGRPLSMML 171
Score = 36.7 bits (81), Expect = 0.65
Identities = 23/83 (27%), Positives = 46/83 (55%), Gaps = 1/83 (1%)
Frame = +2
Query: 263 EIKKE-LKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDS 439
E K E LK +I + + G P ++ I++G+D S Y + K+ +GID + ++R
Sbjct: 10 ETKMERLKNEIEKIKNTGIN-PKMKIILIGNDYGSVVYSKAKMRRGSKLGID-VDLDRYD 67
Query: 440 DITEEQLLSEIQNLNEDNNVDGI 508
I+ E L+ ++ ++ +++ GI
Sbjct: 68 SISREDLIKLLKRYSQSDDIHGI 90
>UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus gnavus ATCC 29149|Rep: Putative
uncharacterized protein - Ruminococcus gnavus ATCC 29149
Length = 276
Score = 54.8 bits (126), Expect = 2e-06
Identities = 30/83 (36%), Positives = 46/83 (55%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+QLP+PD N R+ I PEKD+DGF + C P T +++ ++ N +
Sbjct: 93 IQLPIPDKYNLERLQHLIPPEKDVDGFRKDS----C-----FKPCTPKGIIDWMEYNNFE 143
Query: 691 TFGRNAVVIGRSKNVGMPIAMML 759
G++ V+GRSK VG+P+ ML
Sbjct: 144 FEGKDCCVLGRSKIVGLPLTNML 166
Score = 39.1 bits (87), Expect = 0.12
Identities = 23/80 (28%), Positives = 44/80 (55%)
Frame = +2
Query: 269 KKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDIT 448
KKELK++I ++ P + I + DD AS++Y++ K + +GI+ +N S+ T
Sbjct: 16 KKELKEEIKHL----DKKPVLAVIQIDDDQASNSYIKGKQKDCDEIGIEMRHVNIYSNTT 71
Query: 449 EEQLLSEIQNLNEDNNVDGI 508
E++ + + ++ DGI
Sbjct: 72 EQKEVECVITDIAKSDADGI 91
>UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma penetrans|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma penetrans
Length = 282
Score = 53.6 bits (123), Expect = 5e-06
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 2/81 (2%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTI--VPATALAVVEMLKRFN 684
+QLP+P + +C+ I KDIDG I R + P TA ++E+LK+ N
Sbjct: 92 IQLPLPKGFDSNVICEHIDVNKDIDGLSSFAISRNLANSNLFHPKPCTANGIIEILKQSN 151
Query: 685 IDTFGRNAVVIGRSKNVGMPI 747
G++AV+I RS VG P+
Sbjct: 152 YSIEGKHAVIINRSMIVGKPL 172
Score = 38.7 bits (86), Expect = 0.16
Identities = 23/72 (31%), Positives = 39/72 (54%)
Frame = +2
Query: 323 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNNVD 502
P + + + DD AS YV K++ A +G+ I+ T++ L+ +I LN D+++D
Sbjct: 30 PHMAIVKINDDAASDKYVSIKLKKAAELGVKTTLISEGIK-TQDDLIKQIHILNNDDSID 88
Query: 503 GISSNYLYLIQL 538
G Y+IQL
Sbjct: 89 G------YIIQL 94
>UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma mobile|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma mobile
Length = 280
Score = 53.2 bits (122), Expect = 7e-06
Identities = 27/79 (34%), Positives = 42/79 (53%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+P ++ ++ +++ KDIDG N L I PATA +++++K +N
Sbjct: 89 VQLPLPLQFDQSKILNSVPITKDIDGLSEKNSKNLYSGKSCIQPATARGIIDLIKEYNFT 148
Query: 691 TFGRNAVVIGRSKNVGMPI 747
+ VIG S VG PI
Sbjct: 149 IKDKKVYVIGESNLVGKPI 167
>UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate
dehydrogenase; n=1; Tetrahymena thermophila SB210|Rep:
methylenetetrahydrofolate dehydrogenase - Tetrahymena
thermophila SB210
Length = 342
Score = 52.0 bits (119), Expect = 2e-05
Identities = 24/65 (36%), Positives = 41/65 (63%)
Frame = +2
Query: 314 NRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDN 493
+R P + I+VG++PAS +Y++ K++A + +GI + DI E +LS I NLN +
Sbjct: 46 SRKPGLGIILVGNNPASLSYIKKKLQACEAIGIRHELYHFSEDIQEYDVLSAIDNLNRKD 105
Query: 494 NVDGI 508
++D I
Sbjct: 106 DIDAI 110
Score = 48.0 bits (109), Expect = 3e-04
Identities = 28/82 (34%), Positives = 45/82 (54%)
Frame = +1
Query: 514 QLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDT 693
QLP+P I++ V + I+ EKD DG + N L I+P T A +++L+ I
Sbjct: 113 QLPLPSHIDKNNVINMISSEKDADGLKL-NSNNLDPKA-NILPCTPAACLKILEEHQICL 170
Query: 694 FGRNAVVIGRSKNVGMPIAMML 759
++ V+IGR + VG P+ +L
Sbjct: 171 KDKHVVLIGRGRLVGQPLEQLL 192
>UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma synoviae 53|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma synoviae (strain 53)
Length = 278
Score = 52.0 bits (119), Expect = 2e-05
Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 4/87 (4%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGF----HIINIGRLCVDLPTIVPATALAVVEMLKR 678
+QLP+P + + + DA+ EKDIDG I D VPA A AV+E+++
Sbjct: 91 IQLPLPKHLPKEVILDAVPYEKDIDGLSHRNEFILYNEKNSDDKFFVPAAARAVLELIEH 150
Query: 679 FNIDTFGRNAVVIGRSKNVGMPIAMML 759
I+ + V+GRS VG P+A +L
Sbjct: 151 HEINYKKKKVAVVGRSHLVGKPVAHIL 177
Score = 47.6 bits (108), Expect = 4e-04
Identities = 30/79 (37%), Positives = 49/79 (62%)
Frame = +2
Query: 272 KELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITE 451
K+LK+++ + ++L NR + I VGD S+ YV K++ AK +GI+A D +IT+
Sbjct: 15 KQLKKELDE-LNL-NRPIKLAIIQVGDKMESNRYVEQKLKKAKEIGIEAKCFKFDENITQ 72
Query: 452 EQLLSEIQNLNEDNNVDGI 508
++LL + +NE N DGI
Sbjct: 73 KRLLLAMDEINE--NWDGI 89
>UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Rubrobacter xylanophilus DSM 9941|Rep: Bifunctional
protein folD 2 [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Rubrobacter xylanophilus
(strain DSM 9941 / NBRC 16129)
Length = 320
Score = 52.0 bits (119), Expect = 2e-05
Identities = 32/84 (38%), Positives = 44/84 (52%), Gaps = 9/84 (10%)
Frame = +1
Query: 520 PVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFG 699
P+P I+E V A+ P KDI+ H +N G L + P VP+T A +L R+ ++ G
Sbjct: 99 PLPGHISEPAVFSALDPLKDIEAVHPVNAGLLALGRPRYVPSTPAACFYLLDRY-LERSG 157
Query: 700 R---------NAVVIGRSKNVGMP 744
R VV+GRS NVG P
Sbjct: 158 RPPEEFYPRSTVVVVGRSNNVGKP 181
>UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3;
Bacteria|Rep: Putative uncharacterized protein -
Collinsella aerofaciens ATCC 25986
Length = 284
Score = 47.6 bits (108), Expect = 4e-04
Identities = 28/87 (32%), Positives = 43/87 (49%), Gaps = 1/87 (1%)
Frame = +1
Query: 520 PVPDTINERRVCDAIAPEKDIDGFHIINI-GRLCVDLPTIVPATALAVVEMLKRFNIDTF 696
P+P ++E V A+ P KD+D ++ L P TA AV+ +L + ++
Sbjct: 98 PLPAGLDEDAVAAALDPAKDVDSMTPASLLTTLSGRGEGFAPCTAEAVLALLDHYGVELD 157
Query: 697 GRNAVVIGRSKNVGMPIAMMLHATRDT 777
G V+GRS +G P+A ML A T
Sbjct: 158 GAKVAVVGRSLVIGRPVAAMLTARNAT 184
Score = 37.1 bits (82), Expect = 0.50
Identities = 22/84 (26%), Positives = 44/84 (52%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
+A + +EL + A G P + + VG+ +Y R ++ + VGI+A +
Sbjct: 10 VARALTEELAARCAALREQGV-VPMLAIVRVGEREDDLSYERGALKRCEKVGIEARRVLL 68
Query: 434 DSDITEEQLLSEIQNLNEDNNVDG 505
D+++++LL+ I+++N D V G
Sbjct: 69 PVDVSQDELLAAIKDINADPAVHG 92
>UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein; n=2; Leishmania|Rep:
Methylenetetrahydrofolate dehydrogenase-like protein -
Leishmania major
Length = 207
Score = 46.8 bits (106), Expect = 6e-04
Identities = 24/81 (29%), Positives = 44/81 (54%)
Frame = +2
Query: 266 IKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDI 445
I K+L+Q+I S+ R P + ++VGD S YV +K+ AA GI+ ++ + +
Sbjct: 40 ISKQLRQRIRASTSVLRRPPCLVVVLVGDGADSIHYVNHKMRAAADCGIEVRLVHLSATV 99
Query: 446 TEEQLLSEIQNLNEDNNVDGI 508
+ +L + +N+D VD +
Sbjct: 100 QQIELHRTLAAVNDDVEVDAV 120
>UniRef50_UPI00006CB712 Cluster: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
n=1; Tetrahymena thermophila SB210|Rep: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain -
Tetrahymena thermophila SB210
Length = 377
Score = 46.4 bits (105), Expect = 8e-04
Identities = 26/95 (27%), Positives = 53/95 (55%), Gaps = 1/95 (1%)
Frame = +2
Query: 263 EIKKELKQKIAQWVSLGN-RAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDS 439
+I K++ QK+ + + N R P + I+VG+ S +YV K A K VG+ + I+
Sbjct: 35 KISKDVLQKVKERILRVNIREPKLAIILVGNAADSISYVSVKQRACKRVGVQSELIHLPE 94
Query: 440 DITEEQLLSEIQNLNEDNNVDGISSNYLYLIQLMR 544
T+++++ +++LN+ +VD I + + Q+ +
Sbjct: 95 TTTQKEVIQIVEDLNKREDVDSILTQLPFPAQISK 129
Score = 40.7 bits (91), Expect = 0.040
Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 3/85 (3%)
Frame = +1
Query: 514 QLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV---DLPTIVPATALAVVEMLKRFN 684
QLP P I++ V + I P KD+DG + + + +P T + + +L
Sbjct: 120 QLPFPAQISKTIVINQIEPSKDVDGLQRCFLTQQLIWDDHNNRALPCTPQSCLHILDTHK 179
Query: 685 IDTFGRNAVVIGRSKNVGMPIAMML 759
ID G+ V++G+ VG P+ +L
Sbjct: 180 IDVKGKQVVMLGKGLLVGSPLGAIL 204
>UniRef50_Q21285 Cluster: Dauer or aging adult overexpression
protein 3; n=2; Caenorhabditis|Rep: Dauer or aging adult
overexpression protein 3 - Caenorhabditis elegans
Length = 303
Score = 46.4 bits (105), Expect = 8e-04
Identities = 27/83 (32%), Positives = 43/83 (51%), Gaps = 1/83 (1%)
Frame = +2
Query: 263 EIKKELKQKIAQWVSLGNRAPTIRCII-VGDDPASHTYVRNKVEAAKFVGIDALTINRDS 439
++ ++ QKIA+ + I+ VG+ S+ Y+ +K++ AK +G D I
Sbjct: 14 KVLHDVGQKIAKTREHHPNFHAVLAIVQVGNRSDSNVYINSKLKKAKEIGADGKLIKLPD 73
Query: 440 DITEEQLLSEIQNLNEDNNVDGI 508
IT+ L EI LN DN +DGI
Sbjct: 74 TITQGDLKREIMALNHDNEIDGI 96
Score = 46.0 bits (104), Expect = 0.001
Identities = 34/89 (38%), Positives = 47/89 (52%), Gaps = 7/89 (7%)
Frame = +1
Query: 511 VQLPVP--DTINERRVCDAIAPEKDIDGFHIINIGRLC-VDLP-TIVPATALAVVEMLKR 678
+QLP+ I+ V D I P KD+DG IN GRL +L TI P T + ++++
Sbjct: 98 IQLPLDCKHEIDADSVIDLIDPLKDVDGLTRINAGRLARGELQRTIFPCTPFGCLYLVQQ 157
Query: 679 FNID---TFGRNAVVIGRSKNVGMPIAMM 756
D G+ VV+GRSK VG P A +
Sbjct: 158 ATGDANFVSGKEVVVLGRSKIVGSPAAAL 186
>UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1;
Schistosoma japonicum|Rep: Clone ZZD1003 mRNA sequence -
Schistosoma japonicum (Blood fluke)
Length = 332
Score = 43.6 bits (98), Expect = 0.006
Identities = 27/88 (30%), Positives = 45/88 (51%)
Frame = +2
Query: 248 QSIAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTI 427
+ +A + ++K +A S + P + I VG+ P S Y++ K + AK GI +
Sbjct: 10 RQVAQAVGHKIKLDVALLKSSFDVYPKLVVIEVGELPQSKLYIKQKFKFAKKYGILLSHM 69
Query: 428 NRDSDITEEQLLSEIQNLNEDNNVDGIS 511
S I+E LL + LN D++V GI+
Sbjct: 70 RLPSHISESLLLDYVYKLNADSSVHGIT 97
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 13/96 (13%)
Frame = +1
Query: 511 VQLPVP-DT-INERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIV-----------PATA 651
+QLP DT IN +A+A KD++G + N L V + + TA
Sbjct: 98 LQLPFDSDTNINVTNSLNAVATHKDVEGLNSYNTALLSVVIYSATLRRLKTKTYSYTCTA 157
Query: 652 LAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMML 759
A +++ N G V+IGR + VG P A +L
Sbjct: 158 AACYALIRHVNFPISGSRCVIIGRGRLVGAPTAELL 193
>UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma pulmonis|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma pulmonis
Length = 272
Score = 41.5 bits (93), Expect = 0.023
Identities = 29/84 (34%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Frame = +1
Query: 511 VQLPVPD-TINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNI 687
+QLPV +NE + I KD+DG + N + I+PATA A+ LK I
Sbjct: 90 LQLPVLHFDVNELLLM--IDKNKDLDGLNPENEKAFYENRECIIPATARAIWTFLKFHKI 147
Query: 688 DTFGRNAVVIGRSKNVGMPIAMML 759
+ V+G+S+ VG PI+ L
Sbjct: 148 SVENKKVFVVGQSRLVGKPISQFL 171
Score = 35.1 bits (77), Expect = 2.0
Identities = 21/84 (25%), Positives = 46/84 (54%), Gaps = 1/84 (1%)
Frame = +2
Query: 260 MEIKK-ELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRD 436
++IK+ ELK+K ++ ++ +++GD+ +S YV+ K+E A+ +G++A + +
Sbjct: 11 VQIKRAELKEKFSKL----DQKVKFAIVLIGDNASSKIYVKKKIEFAQDIGVEAKLFHFE 66
Query: 437 SDITEEQLLSEIQNLNEDNNVDGI 508
++ L + + D DGI
Sbjct: 67 ENVDFNLLKDAFKKI--DKEYDGI 88
>UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Deinococcus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Deinococcus radiodurans
Length = 299
Score = 41.1 bits (92), Expect = 0.030
Identities = 22/86 (25%), Positives = 43/86 (50%), Gaps = 1/86 (1%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNR-APTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTIN 430
+A + + ++ + W L P + ++ DD AS YV++K + AK +G+ ++
Sbjct: 20 LADRVMRGVRADLKAWAQLDPPFEPQLVSVLASDDEASQVYVQSKAKRAKKLGVAFRVVD 79
Query: 431 RDSDITEEQLLSEIQNLNEDNNVDGI 508
+ T+E L ++ L+ D V GI
Sbjct: 80 LGAAATQEALEQTLRELSADPAVHGI 105
>UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 14 SCAF14723, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1066
Score = 40.7 bits (91), Expect = 0.040
Identities = 24/70 (34%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Frame = +1
Query: 517 LPVPDTINERRVCDAIAPEKDIDGFHIINIGRLC-VDLPT-IVPATALAVVEMLKRFNID 690
L +P RV A+ PEKD+DG +N G L DL VP AV+E L + ++
Sbjct: 83 LHLPQASLTSRVLTALKPEKDVDGLSDLNTGCLIRGDLSAGFVPPVTSAVLEWLSKHHVT 142
Query: 691 TFGRNAVVIG 720
G+ +++G
Sbjct: 143 LEGKTVLILG 152
>UniRef50_Q4DH06 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein, putative; n=1; Trypanosoma
cruzi|Rep: Methylenetetrahydrofolate dehydrogenase-like
protein, putative - Trypanosoma cruzi
Length = 375
Score = 40.3 bits (90), Expect = 0.053
Identities = 21/77 (27%), Positives = 43/77 (55%)
Frame = +2
Query: 278 LKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQ 457
L ++I V+ + +P++ ++VG+ S YV K A+ GI ++ ++EE+
Sbjct: 15 LIERIQHEVARLSCSPSLAVVMVGNRQDSRRYVSVKQRTAEACGIRFHLLSLPETVSEER 74
Query: 458 LLSEIQNLNEDNNVDGI 508
L E++ +++DN DG+
Sbjct: 75 LHQELRRISDDNAFDGV 91
Score = 37.9 bits (84), Expect = 0.28
Identities = 17/38 (44%), Positives = 22/38 (57%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD 624
+QLP+P + R I P KD+DG H IN G L +D
Sbjct: 93 LQLPIPSHLRVRPALLCIHPGKDVDGLHPINAGSLFLD 130
>UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate
formyltetrahydrofolate synthetase domain containing 1;
n=1; Danio rerio|Rep: Novel protein similar to
vertebrate formyltetrahydrofolate synthetase domain
containing 1 - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 217
Score = 36.3 bits (80), Expect = 0.86
Identities = 20/59 (33%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Frame = +1
Query: 517 LPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPT--IVPATALAVVEMLKRFNI 687
L +P T + V +AI P+KD+DG +N+GR+ + T A AV+E+L + +
Sbjct: 82 LHLPQTFLSKSVRNAIKPQKDVDGVCDLNVGRVVLGDKTDGFTSPVAGAVLELLAKHGV 140
Score = 35.1 bits (77), Expect = 2.0
Identities = 21/62 (33%), Positives = 33/62 (53%)
Frame = +2
Query: 323 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNNVD 502
PT+ I G+D NK A K +G++ + I TEE+++ E+ LN+D+ V
Sbjct: 22 PTLAIIQAGEDDG--LLEMNKKMAGK-IGLNVMQICLPHRCTEEEVIEEVLRLNKDSRVH 78
Query: 503 GI 508
GI
Sbjct: 79 GI 80
>UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=1; Chlorobaculum tepidum|Rep:
Methylenetetrahydrofolate dehydrogenase - Chlorobium
tepidum
Length = 296
Score = 35.9 bits (79), Expect = 1.1
Identities = 27/99 (27%), Positives = 47/99 (47%), Gaps = 15/99 (15%)
Frame = +1
Query: 508 FVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVD---------LPTIVPATALAV 660
FV P+ + + D I+P KD++G I +L + +I+P T LA+
Sbjct: 86 FVYYPIWGDKRDAELRDLISPHKDVEGLSPHWIKKLYANERFDDTERRFKSILPCTPLAI 145
Query: 661 VEMLK------RFNIDTFGRNAVVIGRSKNVGMPIAMML 759
+++L+ F + G+ + RS+ VG P+A ML
Sbjct: 146 IKLLEVTEAYAPFGLPFGGQQITIFNRSEVVGRPLAYML 184
>UniRef50_P47259 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Mycoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma genitalium
Length = 273
Score = 35.9 bits (79), Expect = 1.1
Identities = 23/79 (29%), Positives = 39/79 (49%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
+QLPV +++ + +AI P KD+DG + L I P A++ + + FN++
Sbjct: 87 LQLPVYPHLDKNSLLEAINPLKDVDGLTTNH-------LAEIKPCIVEAIITLKELFNLE 139
Query: 691 TFGRNAVVIGRSKNVGMPI 747
+ VV+G G PI
Sbjct: 140 FNNQKIVVVGLGITGGKPI 158
>UniRef50_Q6LTH4 Cluster: Putative uncharacterized protein; n=3;
Gammaproteobacteria|Rep: Putative uncharacterized
protein - Photobacterium profundum (Photobacterium sp.
(strain SS9))
Length = 486
Score = 33.9 bits (74), Expect = 4.6
Identities = 19/74 (25%), Positives = 36/74 (48%)
Frame = -1
Query: 740 IPTFLERPITTALRPNVSMLNLFSISTTANAVAGTMVGRSTHSLPMLIMWKPSISFSGAI 561
+PTFL ++ ++ V++ LF++ +TAN+V + G +H L I +S +
Sbjct: 313 MPTFLANFLSPSMSAVVTLFILFAMKSTANSVLHAIAGSVSHDLRQAIWPNCRLSEKSLL 372
Query: 560 ASQTLLSLIVSGTG 519
++ GTG
Sbjct: 373 ILNRSAVWLLGGTG 386
>UniRef50_Q62L13 Cluster: Hydrolase; n=16; Burkholderia|Rep:
Hydrolase - Burkholderia mallei (Pseudomonas mallei)
Length = 330
Score = 33.9 bits (74), Expect = 4.6
Identities = 24/72 (33%), Positives = 36/72 (50%)
Frame = +1
Query: 505 NFVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFN 684
N V LP+PD R A+ + G+H+ + R DLP I+P A+++ R
Sbjct: 155 NLVGLPIPDFTAPR--WRALLARANALGWHV-EVHRRAADLPAIIP----ALLDQSCRVV 207
Query: 685 IDTFGRNAVVIG 720
+D FGR A +G
Sbjct: 208 VDHFGRPAPHLG 219
>UniRef50_Q6X5D4 Cluster: Methylene-THF dehydrogenase; n=1;
Treponema primitia|Rep: Methylene-THF dehydrogenase -
Treponema primitia
Length = 97
Score = 33.9 bits (74), Expect = 4.6
Identities = 22/84 (26%), Positives = 38/84 (45%)
Frame = +2
Query: 254 IAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINR 433
+A + + LK+ + + G PT+ I +G+ +Y + + A+ VG
Sbjct: 10 VAAALAESLKKDVEALKAKGV-TPTLGIIRLGEKGPDISYEKGATKRAEEVGAAVKNYIL 68
Query: 434 DSDITEEQLLSEIQNLNEDNNVDG 505
D T+E LL I+ N+D V G
Sbjct: 69 PEDTTQEALLKVIKEANDDKGVHG 92
>UniRef50_Q7NAE4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Mycoplasma gallisepticum|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma gallisepticum
Length = 283
Score = 33.9 bits (74), Expect = 4.6
Identities = 18/84 (21%), Positives = 37/84 (44%)
Frame = +1
Query: 511 VQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVVEMLKRFNID 690
VQLP+ + ++ ++ + I D+D F + ++P AV+E+ K + +
Sbjct: 90 VQLPIKERLDTNKIIENIPIRLDVDAFLYHRFDQ--DQKEKVIPCVLNAVLELFKEYQLS 147
Query: 691 TFGRNAVVIGRSKNVGMPIAMMLH 762
+ ++IG PI L+
Sbjct: 148 FLDKKILLIGNGITSNQPIVNYLN 171
>UniRef50_Q55FD5 Cluster: Putative glycosyltransferase; n=1;
Dictyostelium discoideum AX4|Rep: Putative
glycosyltransferase - Dictyostelium discoideum AX4
Length = 550
Score = 33.5 bits (73), Expect = 6.1
Identities = 26/95 (27%), Positives = 42/95 (44%), Gaps = 3/95 (3%)
Frame = +2
Query: 251 SIAMEIKKELKQKIAQWVSLGNRAPTIRCIIV---GDDPASHTYVRNKVEAAKFVGIDAL 421
SI + E +KIA + RAP +++ D + + +RN + ++FV L
Sbjct: 132 SIVTHVPIENMEKIAMIADIW-RAPISASVLIKNKNDIDSVYKLIRNSLSVSEFVDFHFL 190
Query: 422 TINRDSDITEEQLLSEIQNLNEDNNVDGISSNYLY 526
N DSD + I N N+ N + + NY Y
Sbjct: 191 YWNEDSDSIINNNNNNIINKNKINTNEEDNLNYYY 225
>UniRef50_Q4S3A9 Cluster: Chromosome 4 SCAF14752, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 4 SCAF14752, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1001
Score = 33.1 bits (72), Expect = 8.1
Identities = 18/58 (31%), Positives = 21/58 (36%)
Frame = +3
Query: 591 PHNQHRKAVCGSTYHCAGYSIGCSGNAEKI*HRHIRSQRGRDRSFQKRRYAYRYDAAC 764
P HR A+CG GY G G E RH RG + +A R C
Sbjct: 278 PPRDHRDALCGQLCRRLGYQAGADGRGEGAAGRHASRLRGDRENPGNSEHAQRPGPRC 335
>UniRef50_A7NLG5 Cluster: Sodium/hydrogen exchanger; n=1;
Roseiflexus castenholzii DSM 13941|Rep: Sodium/hydrogen
exchanger - Roseiflexus castenholzii DSM 13941
Length = 400
Score = 33.1 bits (72), Expect = 8.1
Identities = 20/80 (25%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Frame = -1
Query: 749 AIGIPTFLERPITTALRPNVSMLN---LFSISTTANAVAGTMVGRSTHSLPMLIMWKPSI 579
A +P F + L NV+ L LF+I A A+AG +VG ++ M + W+ ++
Sbjct: 272 AFVVPVFF---VNIGLEANVTTLGAMPLFTIIMVALAIAGKVVGCGVGAMAMRLSWREAV 328
Query: 578 SFSGAIASQTLLSLIVSGTG 519
+ ++ ++L++ G
Sbjct: 329 QIGVGMVARGEVALVMIAAG 348
>UniRef50_Q8ILG1 Cluster: Putative uncharacterized protein; n=3;
Aconoidasida|Rep: Putative uncharacterized protein -
Plasmodium falciparum (isolate 3D7)
Length = 2657
Score = 33.1 bits (72), Expect = 8.1
Identities = 16/53 (30%), Positives = 32/53 (60%)
Frame = +2
Query: 347 GDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNNVDG 505
GD+ + + +NK + K V I+ + IN D++I + ++ N+N +NN++G
Sbjct: 1290 GDNMYKYEHGKNKEDTIKPVDIN-ININGDNNINGDNNINGDNNINGENNING 1341
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 767,781,917
Number of Sequences: 1657284
Number of extensions: 15570244
Number of successful extensions: 44930
Number of sequences better than 10.0: 111
Number of HSP's better than 10.0 without gapping: 42564
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 44829
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 66262109095
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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