Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= pg--0143.Seq
(754 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 139 8e-32
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 138 1e-31
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 120 5e-26
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 116 8e-25
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 113 3e-24
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 113 4e-24
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 112 1e-23
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 112 1e-23
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 111 2e-23
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 109 9e-23
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 108 2e-22
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 107 4e-22
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 103 4e-21
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 101 1e-20
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 100 3e-20
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 92 1e-17
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 88 2e-16
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 88 3e-16
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 87 6e-16
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 83 5e-15
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 83 5e-15
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 83 5e-15
UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 83 5e-15
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 81 2e-14
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 79 9e-14
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 79 1e-13
UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n... 78 3e-13
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 75 1e-12
UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenas... 75 3e-12
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 75 3e-12
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 75 3e-12
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 74 4e-12
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 73 8e-12
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 71 2e-11
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 71 4e-11
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 68 3e-10
UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenas... 63 8e-09
UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;... 63 8e-09
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 62 1e-08
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 61 3e-08
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 60 6e-08
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 59 1e-07
UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|R... 56 7e-07
UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8; ... 56 9e-07
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 56 1e-06
UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subuni... 55 2e-06
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 52 1e-05
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 52 1e-05
UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1; N... 52 2e-05
UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2... 52 2e-05
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 51 3e-05
UniRef50_Q1IMD5 Cluster: 3-isopropylmalate dehydrogenase; n=1; A... 51 3e-05
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 51 3e-05
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 51 4e-05
UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3; Proteobact... 50 5e-05
UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50; ... 50 5e-05
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 50 6e-05
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 49 1e-04
UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 49 1e-04
UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila melanogaster|... 49 1e-04
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 49 1e-04
UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp - Pa... 48 2e-04
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 48 3e-04
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 47 6e-04
UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 47 6e-04
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 46 8e-04
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 46 8e-04
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 46 0.001
UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1; ... 46 0.001
UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5; E... 46 0.001
UniRef50_Q44471 Cluster: Probable tartrate dehydrogenase/decarbo... 45 0.002
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 45 0.002
UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72; ... 44 0.003
UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2; T... 44 0.004
UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3, chlo... 42 0.016
UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2; B... 42 0.022
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 42 0.022
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 42 0.022
UniRef50_Q3ZXI7 Cluster: 3-isopropylmalate dehydrogenase; n=66; ... 42 0.022
UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 42 0.022
UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependen... 41 0.038
UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 40 0.050
UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenas... 40 0.066
UniRef50_A6GJ83 Cluster: Isocitrate dehydrogenase; n=1; Plesiocy... 40 0.087
UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;... 39 0.12
UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|R... 39 0.15
UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 36 0.81
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 36 1.4
UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 36 1.4
UniRef50_Q6BHK1 Cluster: Similar to CA1897|IPF12002 Candida albi... 35 1.9
UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyc... 35 2.5
UniRef50_UPI000065D57A Cluster: Putative polypeptide N-acetylgal... 34 3.3
UniRef50_Q89UQ9 Cluster: Aminobenzoyl-glutamate utilization prot... 33 5.7
UniRef50_Q8IC48 Cluster: Putative uncharacterized protein PF07_0... 33 5.7
UniRef50_Q7RM75 Cluster: Protein phosphatase; n=6; Plasmodium (V... 33 5.7
UniRef50_Q4WN09 Cluster: ABC transporter, putative; n=12; Pezizo... 33 5.7
UniRef50_A3BGI7 Cluster: Putative uncharacterized protein; n=1; ... 33 7.6
UniRef50_O14122 Cluster: Cullin-4; n=1; Schizosaccharomyces pomb... 33 7.6
UniRef50_UPI000065E6FA Cluster: 1-phosphatidylinositol-4,5-bisph... 33 10.0
UniRef50_A3W960 Cluster: SCO1/SenC family protein; n=2; Roseovar... 33 10.0
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 139 bits (336), Expect = 8e-32
Identities = 64/81 (79%), Positives = 73/81 (90%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IRQNTEGEYAMLEHESV GVVESMKVVT +N+ RVAR+AFEFA+ N RKKVTT+HKANIM
Sbjct: 161 IRQNTEGEYAMLEHESVRGVVESMKVVTVENAARVARYAFEFARANNRKKVTTIHKANIM 220
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
KL+DGLFL +R +AK+YPDI
Sbjct: 221 KLADGLFLSVAREVAKDYPDI 241
Score = 125 bits (302), Expect = 1e-27
Identities = 54/85 (63%), Positives = 70/85 (82%)
Frame = +2
Query: 257 GAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELD 436
G P+DFEVVDIDP + +DD++YAIT+IKRNGV LKGNIETKSEA + SRNVALRNELD
Sbjct: 76 GVPVDFEVVDIDPASEGNDDLEYAITSIKRNGVALKGNIETKSEATGIISRNVALRNELD 135
Query: 437 MYAYILNCKSYPGVATRHKDIDVVL 511
+Y +L+CKS+ + H+++DVV+
Sbjct: 136 LYVNVLHCKSFNAIPAHHQNVDVVI 160
Score = 81.4 bits (192), Expect = 2e-14
Identities = 33/52 (63%), Positives = 43/52 (82%)
Frame = +3
Query: 102 SDFDVQHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYS 257
S F++QHK P+ RK + IPKA YGGRH VTMLPGGGIGPE M YV+++F+++
Sbjct: 24 SAFELQHKNPLQRKVEKIPKAHYGGRHTVTMLPGGGIGPELMNYVKEVFRFA 75
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 138 bits (334), Expect = 1e-31
Identities = 62/81 (76%), Positives = 75/81 (92%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IRQNT+GEYAMLEHESV G+VESMKVVT +N+ERVAR+AFEFA++N RKKVTT+HKANIM
Sbjct: 169 IRQNTDGEYAMLEHESVPGIVESMKVVTVENAERVARYAFEFARQNNRKKVTTIHKANIM 228
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
KLSDGLFLE + R+ K+YP++
Sbjct: 229 KLSDGLFLEVANRVHKDYPEL 249
Score = 132 bits (320), Expect = 7e-30
Identities = 58/85 (68%), Positives = 72/85 (84%)
Frame = +2
Query: 257 GAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELD 436
GAPIDFEV+DIDP+ + +DD+ YAIT+IKRNGV LKGNIETKS++ SRNVA+RNELD
Sbjct: 84 GAPIDFEVIDIDPSTEGNDDLDYAITSIKRNGVALKGNIETKSQSLTEVSRNVAIRNELD 143
Query: 437 MYAYILNCKSYPGVATRHKDIDVVL 511
+Y +++CKSYPG+ RH DIDVVL
Sbjct: 144 LYVNVVHCKSYPGIPARHHDIDVVL 168
Score = 73.7 bits (173), Expect = 4e-12
Identities = 34/51 (66%), Positives = 39/51 (76%), Gaps = 3/51 (5%)
Frame = +3
Query: 111 DVQHKTPVIRKQKL---IPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKY 254
DV H ++K+ IP AQYGGRHAVTMLPGGGIGPE MGYVR+IF+Y
Sbjct: 32 DVAHTKSALQKKVTGTDIPSAQYGGRHAVTMLPGGGIGPELMGYVREIFRY 82
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 120 bits (288), Expect = 5e-26
Identities = 57/81 (70%), Positives = 68/81 (83%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR+NTEGEYA LEHE V GVVES+KV+T SER+A++AFE+A N RKKVT VHKANIM
Sbjct: 146 IRENTEGEYAGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIM 205
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
KL+DGLFLE+ R +AK+YP I
Sbjct: 206 KLADGLFLESCREVAKKYPSI 226
Score = 62.5 bits (145), Expect = 1e-08
Identities = 33/89 (37%), Positives = 55/89 (61%)
Frame = +2
Query: 245 IQILGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALR 424
++ + API FE D+ M + +I++N V LKG ++T V+S NV LR
Sbjct: 60 MEAMHAPIFFEKYDVHGEMSRVPPE--VMESIRKNKVCLKGGLKTPVGGG-VSSLNVQLR 116
Query: 425 NELDMYAYILNCKSYPGVATRHKDIDVVL 511
ELD++A ++NC + PG+ TRH+++D+V+
Sbjct: 117 KELDLFASLVNCFNLPGLPTRHENVDIVV 145
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 116 bits (278), Expect = 8e-25
Identities = 56/81 (69%), Positives = 66/81 (81%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR+NTEGEY+ LEHE V GVVES+KV+T SER+AR+AFE+A N RKKVT VHKANIM
Sbjct: 147 IRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYLNNRKKVTAVHKANIM 206
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
KL+DGLFLE+ R +AK Y I
Sbjct: 207 KLADGLFLESCREVAKHYSGI 227
Score = 62.5 bits (145), Expect = 1e-08
Identities = 34/97 (35%), Positives = 58/97 (59%)
Frame = +2
Query: 221 VHGIRSRHIQILGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYV 400
V G + ++ + AP+ FE ++ M + I ++KRN V LKG + T V
Sbjct: 53 VTGAVEQVMEAMHAPVHFERYEVLGNMRKVPEE--VIESVKRNKVCLKGGLATPVGGG-V 109
Query: 401 TSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVL 511
+S N+ LR ELD++A ++NC + PG+ TRH+++D+V+
Sbjct: 110 SSLNMQLRKELDIFASLVNCINVPGLVTRHENVDIVV 146
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 113 bits (273), Expect = 3e-24
Identities = 52/81 (64%), Positives = 66/81 (81%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR+ TEGEY+ LEHESV G+VE +K++TA S R+A+FAF++A KN RKKVT+VHKANIM
Sbjct: 154 IREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYAIKNSRKKVTSVHKANIM 213
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
KL DGLFL++ +AK YP I
Sbjct: 214 KLGDGLFLKSCEDMAKLYPRI 234
Score = 62.1 bits (144), Expect = 1e-08
Identities = 33/88 (37%), Positives = 57/88 (64%), Gaps = 5/88 (5%)
Frame = +2
Query: 263 PIDFE---VVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETK--SEAAYVTSRNVALRN 427
P+DFE + +++P + ++ I +I++N V +KG + T S + S N+ LRN
Sbjct: 68 PVDFECYFLSEVNPVLSAK--LEDVIASIRKNKVCIKGVLATPDYSNVGELQSLNMKLRN 125
Query: 428 ELDMYAYILNCKSYPGVATRHKDIDVVL 511
ELD+YA +++ +S PGV TR++DID+V+
Sbjct: 126 ELDLYANVVHARSLPGVKTRYQDIDIVV 153
Score = 33.9 bits (74), Expect = 4.3
Identities = 13/32 (40%), Positives = 21/32 (65%)
Frame = +3
Query: 156 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFK 251
P A G R T++PG G+GPE + ++++FK
Sbjct: 32 PGALGGNRTTCTLIPGDGVGPELVQCLQEVFK 63
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 113 bits (272), Expect = 4e-24
Identities = 51/81 (62%), Positives = 65/81 (80%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
+R+NTEGEY+ LEHESV GVVES+K++T S R+A +AF+ A+++GRKKVT VHKANIM
Sbjct: 166 VRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIM 225
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
KL DGLFL+ R +A YP I
Sbjct: 226 KLGDGLFLQCCREVAARYPQI 246
Score = 85.8 bits (203), Expect = 1e-15
Identities = 42/84 (50%), Positives = 56/84 (66%), Gaps = 1/84 (1%)
Frame = +2
Query: 263 PIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYV-TSRNVALRNELDM 439
P+DFE V + D ++D++ AI I+RN V LKGNIET SRN LR LD+
Sbjct: 83 PVDFEEVHVSSNAD-EEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDL 141
Query: 440 YAYILNCKSYPGVATRHKDIDVVL 511
YA +++CKS PGV TRHKDID+++
Sbjct: 142 YANVIHCKSLPGVVTRHKDIDILI 165
Score = 56.0 bits (129), Expect = 9e-07
Identities = 23/49 (46%), Positives = 35/49 (71%), Gaps = 3/49 (6%)
Frame = +3
Query: 120 HKTP---VIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYS 257
H+ P + +Q + P A+YGGRH VTM+PG GIGPE M +V+ +F+++
Sbjct: 32 HEVPSRNIFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHA 80
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 112 bits (269), Expect = 1e-23
Identities = 55/82 (67%), Positives = 64/82 (78%), Gaps = 1/82 (1%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR+NTEGE++ LEHESV GVVES+KV+T +ER+ARFAF+FAKK RK VT VHKANIM
Sbjct: 139 IRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIM 198
Query: 691 KLSDGLFLETSRRLA-KEYPDI 753
KL DGLF + KEYPDI
Sbjct: 199 KLGDGLFRNIITEIGQKEYPDI 220
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/89 (42%), Positives = 56/89 (62%), Gaps = 1/89 (1%)
Frame = +2
Query: 263 PIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMY 442
PID+E ++I T D+ + V A+ ++KRN +GLKG T ++ S NVALR +LD+Y
Sbjct: 57 PIDWETINIKQT-DHKEGVYEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIY 115
Query: 443 AYILNCKSYPGVATRHKDID-VVLSDRTQ 526
A + KS GV TR DID +V+ + T+
Sbjct: 116 ANVALFKSLKGVKTRIPDIDLIVIRENTE 144
Score = 39.5 bits (88), Expect = 0.087
Identities = 17/36 (47%), Positives = 25/36 (69%)
Frame = +3
Query: 144 QKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFK 251
++ +PK +YGGR VT++PG G+G E VR IF+
Sbjct: 18 ERTLPK-KYGGRFTVTLIPGDGVGKEITDSVRTIFE 52
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 112 bits (269), Expect = 1e-23
Identities = 54/82 (65%), Positives = 64/82 (78%), Gaps = 1/82 (1%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR+NTEGEY+ LEHESV GVVES+K++T SER+ARFAF+FA KN RK V VHKANIM
Sbjct: 140 IRENTEGEYSGLEHESVPGVVESLKIMTRAKSERIARFAFDFALKNNRKSVCAVHKANIM 199
Query: 691 KLSDGLFLETSRRL-AKEYPDI 753
KL DGLF T + A EYP++
Sbjct: 200 KLGDGLFRNTVNEIGANEYPEL 221
Score = 72.9 bits (171), Expect = 8e-12
Identities = 38/83 (45%), Positives = 56/83 (67%)
Frame = +2
Query: 263 PIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMY 442
PID+E +DI ++N ++VQ A+ ++KRN VGLKG T ++ S NVALR +LD++
Sbjct: 58 PIDWETIDISG-LENTENVQRAVESLKRNKVGLKGIWHTPADQTGHGSLNVALRKQLDIF 116
Query: 443 AYILNCKSYPGVATRHKDIDVVL 511
A + KS PGV TR +ID+V+
Sbjct: 117 ANVALFKSIPGVKTRLNNIDMVI 139
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/36 (47%), Positives = 26/36 (72%)
Frame = +3
Query: 144 QKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFK 251
++L+PK +YGGR+ VT++PG G+G E V IF+
Sbjct: 19 EQLLPK-KYGGRYTVTLIPGDGVGKEVTDSVVKIFE 53
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 111 bits (267), Expect = 2e-23
Identities = 47/81 (58%), Positives = 67/81 (82%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
+R+NTEG Y+ +EHE V GVVES+K++T S R+++FAF +A+K GRKK+ ++HKANIM
Sbjct: 116 VRENTEGLYSGIEHEVVPGVVESLKIITEKASTRISKFAFNYARKMGRKKIHSIHKANIM 175
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
K+SDGLF+ SR ++KEYP+I
Sbjct: 176 KMSDGLFIRCSRNISKEYPEI 196
Score = 43.6 bits (98), Expect = 0.005
Identities = 21/59 (35%), Positives = 36/59 (61%)
Frame = +2
Query: 335 TIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVL 511
+I+R +GLKG + T + +S NV LR ++YA + ++ PGV TR+ +D+V+
Sbjct: 58 SIERTRIGLKGPVTTPIGGGF-SSINVELRKRFELYANVRPIRNLPGVHTRYPGVDLVV 115
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 109 bits (261), Expect = 9e-23
Identities = 49/81 (60%), Positives = 62/81 (76%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR+ TEGEY+ LEHES GV+E +K+VT S+R+A+FAF++A K GR KVT VHKANIM
Sbjct: 163 IREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIM 222
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
KL DGLFL+ +A+ YP I
Sbjct: 223 KLGDGLFLQCCEEVAELYPKI 243
Score = 52.4 bits (120), Expect = 1e-05
Identities = 25/86 (29%), Positives = 52/86 (60%), Gaps = 3/86 (3%)
Frame = +2
Query: 263 PIDFEVVDIDPT--MDNDDDVQYAITTIKRNGVGLKGNIETKSE-AAYVTSRNVALRNEL 433
P++F+ + M +++ ++ ++++K N V + G I T E + S ++ LR +L
Sbjct: 77 PVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKL 136
Query: 434 DMYAYILNCKSYPGVATRHKDIDVVL 511
D++A +++ KS PG TRH ++D+V+
Sbjct: 137 DLFANVVHVKSLPGYMTRHNNLDLVI 162
Score = 37.1 bits (82), Expect = 0.46
Identities = 15/26 (57%), Positives = 19/26 (73%)
Frame = +3
Query: 174 GRHAVTMLPGGGIGPECMGYVRDIFK 251
G VTMLPG G+GPE M V+++FK
Sbjct: 47 GSFPVTMLPGDGVGPELMHAVKEVFK 72
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 108 bits (259), Expect = 2e-22
Identities = 47/81 (58%), Positives = 65/81 (80%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IRQNTEGEY+ LEHE+V+GV+E++KV T + ++A++AF+FA+K+ RKKVT VHKANIM
Sbjct: 168 IRQNTEGEYSHLEHENVSGVIENLKVTTEEACMKIAQYAFDFAEKHDRKKVTAVHKANIM 227
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
K+ DGLFL ++ YP+I
Sbjct: 228 KMGDGLFLRCCEEMSHSYPNI 248
Score = 75.8 bits (178), Expect = 1e-12
Identities = 40/92 (43%), Positives = 58/92 (63%), Gaps = 6/92 (6%)
Frame = +2
Query: 254 LGAPIDFEVVDIDPTMDNDDD-----VQYAITTIKRNGVGLKGNIETKSEAAY-VTSRNV 415
+G P+DFE +++ D+D AIT+IKRNGV +KGNI T +A S N+
Sbjct: 76 IGVPVDFEELNLSGLDIKDEDSYLGAFNEAITSIKRNGVAMKGNIFTPLDAIPGFRSLNL 135
Query: 416 ALRNELDMYAYILNCKSYPGVATRHKDIDVVL 511
LR LD++A I+ CKS PG+ TRH ++D+V+
Sbjct: 136 ELRVHLDLFANIVRCKSIPGIQTRHNNVDLVI 167
Score = 48.0 bits (109), Expect = 2e-04
Identities = 19/33 (57%), Positives = 27/33 (81%)
Frame = +3
Query: 156 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKY 254
P A+YGGR+ VT++PG GIGPE + V+DIF++
Sbjct: 43 PPARYGGRNTVTLIPGDGIGPEMVVAVQDIFRH 75
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 107 bits (256), Expect = 4e-22
Identities = 51/81 (62%), Positives = 62/81 (76%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR+NTEGEY+ +EHE V GVV+S+K++T S VA FAFE+A++NGRK VT VHKANIM
Sbjct: 138 IRENTEGEYSGIEHEIVPGVVQSIKLITETASRNVASFAFEYARQNGRKVVTAVHKANIM 197
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
+ SDGLFL R A YPDI
Sbjct: 198 RQSDGLFLSICREQAALYPDI 218
Score = 49.2 bits (112), Expect = 1e-04
Identities = 30/86 (34%), Positives = 45/86 (52%), Gaps = 3/86 (3%)
Frame = +2
Query: 260 APIDFEVVDIDPTMDNDDDVQY---AITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNE 430
API ++ VD+ P D + I + N VGLKG +ET + S N+A+R E
Sbjct: 52 APIAWDPVDVTPVKGRDGVFRIPSRCIELMHANKVGLKGPLETPIGKGH-RSLNLAVRKE 110
Query: 431 LDMYAYILNCKSYPGVATRHKDIDVV 508
+YA + C+S G T + ++DVV
Sbjct: 111 FSLYANVRPCRSLEGHKTLYDNVDVV 136
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 103 bits (248), Expect = 4e-21
Identities = 47/81 (58%), Positives = 64/81 (79%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR+NTEGEY+ LEH+ V GVVES+K++T S RVA +AF +AK +GRKKV+ +HKANIM
Sbjct: 157 IRENTEGEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIM 216
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
+ +DGLFL+ +A +YP+I
Sbjct: 217 QKTDGLFLQCCDEVAAKYPEI 237
Score = 48.4 bits (110), Expect = 2e-04
Identities = 23/60 (38%), Positives = 37/60 (61%)
Frame = +2
Query: 329 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVV 508
+ ++ +N VGLKG + T + S N+ LR EL++YA + C S PG TR+ D+D++
Sbjct: 97 LQSVLKNKVGLKGPMATPIGKGH-RSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLI 155
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 101 bits (243), Expect = 1e-20
Identities = 46/81 (56%), Positives = 63/81 (77%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR+NTEGEY+ +EH V+GVV+S+K++T S+R+A FAFE+A+ N R VT VHKANIM
Sbjct: 145 IRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIM 204
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
++SDGLFL+ R +A+ DI
Sbjct: 205 RMSDGLFLQKCREVAESCKDI 225
Score = 34.3 bits (75), Expect = 3.3
Identities = 20/55 (36%), Positives = 25/55 (45%)
Frame = +3
Query: 84 AAPATLSDFDVQHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIF 248
A PA +S V K + + GG VT++PG GIGPE V IF
Sbjct: 2 AGPAWISK--VSRLLGAFHNPKQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIF 54
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 100 bits (240), Expect = 3e-20
Identities = 44/81 (54%), Positives = 63/81 (77%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR+NTEGEY+ +EH GVV+S+K++T D SERV R+AFE+A+ GR +V VHK+ I
Sbjct: 149 IRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQ 208
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
+L+DGLF+ ++ L+KEYPD+
Sbjct: 209 RLADGLFVNVAKELSKEYPDL 229
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 92.3 bits (219), Expect = 1e-17
Identities = 42/84 (50%), Positives = 60/84 (71%), Gaps = 1/84 (1%)
Frame = +2
Query: 263 PIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETK-SEAAYVTSRNVALRNELDM 439
P+DFEVV ++ + ++DD+ AI I+RNGV LKGNIET + SRN LR LD+
Sbjct: 79 PVDFEVVHVNSSSTSEDDISNAIMAIRRNGVALKGNIETNHTMPPNHKSRNNLLRTSLDL 138
Query: 440 YAYILNCKSYPGVATRHKDIDVVL 511
YA +++C+S PGV TRHK+ID+++
Sbjct: 139 YANVMHCQSLPGVQTRHKNIDIII 162
Score = 56.0 bits (129), Expect = 9e-07
Identities = 22/47 (46%), Positives = 33/47 (70%)
Frame = +3
Query: 117 QHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYS 257
Q P + + P A+YGGRH VT++PG GIGPE + +VR++F++S
Sbjct: 30 QRGKPTYSGRIIPPPAKYGGRHTVTLIPGDGIGPELLNHVRELFRFS 76
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 88.2 bits (209), Expect = 2e-16
Identities = 41/81 (50%), Positives = 56/81 (69%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
+R NTEGEY+ LE ES+N VVES++ VT R+A +AF+ A + G KKVT +KANIM
Sbjct: 43 VRDNTEGEYSNLEDESMNRVVESLRTVTKAKCLRLAEYAFQLAHRMGCKKVTATYKANIM 102
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
+L D LF++ R +A YP +
Sbjct: 103 RLGDCLFIQCCREVASHYPQL 123
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 87.8 bits (208), Expect = 3e-16
Identities = 41/81 (50%), Positives = 58/81 (71%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
+R+NTE Y E V E+++V+T + SER+AR+AFE AK+ GRKKVT +HKAN+M
Sbjct: 111 VRENTECLYMGFEF-GFGDVTEAIRVITREASERIARYAFELAKREGRKKVTALHKANVM 169
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
K + GLF + R +AK+YP+I
Sbjct: 170 KKTCGLFRDVCREVAKDYPEI 190
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 86.6 bits (205), Expect = 6e-16
Identities = 40/67 (59%), Positives = 50/67 (74%)
Frame = +1
Query: 517 QNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKL 696
+NTEGEY+ LEHESV GV ES+K++T S R+A +AF+ A+K G KKV VHK NI KL
Sbjct: 35 ENTEGEYSNLEHESVKGVTESLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKL 94
Query: 697 SDGLFLE 717
DG FL+
Sbjct: 95 GDGPFLQ 101
Score = 35.9 bits (79), Expect = 1.1
Identities = 13/31 (41%), Positives = 22/31 (70%)
Frame = +2
Query: 419 LRNELDMYAYILNCKSYPGVATRHKDIDVVL 511
L LD+YA +++ K+ P V T HKD+D+++
Sbjct: 2 LHTTLDLYASVIHLKNLPNVETWHKDVDILV 32
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 83.4 bits (197), Expect = 5e-15
Identities = 34/59 (57%), Positives = 52/59 (88%)
Frame = +1
Query: 577 SMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEYPDI 753
++K ++++ SER+ARFAFE+A+++ R+KVT VHKANI+K +DGLFLE +R++A EYPD+
Sbjct: 159 AVKPISSEASERIARFAFEYARRHARRKVTAVHKANILKHTDGLFLEAARQVASEYPDV 217
Score = 44.4 bits (100), Expect = 0.003
Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 5/87 (5%)
Frame = +2
Query: 266 IDFEVVDIDP---TMDNDDDVQYA--ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNE 430
IDFE V +D M+ A I ++ + +KG I T + + + S NVALR
Sbjct: 31 IDFEWVVVDAGAEVMEKSGTPLPAPVIEAVRASDAAIKGPITTPAGSG-IRSVNVALRRA 89
Query: 431 LDMYAYILNCKSYPGVATRHKDIDVVL 511
LD+YA + ++ PGV +R+ +ID+V+
Sbjct: 90 LDLYANLRPARTLPGVHSRYDNIDLVV 116
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 83.4 bits (197), Expect = 5e-15
Identities = 36/63 (57%), Positives = 49/63 (77%)
Frame = +1
Query: 565 GVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEY 744
G +K ++ S R+ +FAFE+A++NGRKKVT VHKANIMK +DGLFL+ +R +A+EY
Sbjct: 154 GSAIGIKPISEFGSRRIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEY 213
Query: 745 PDI 753
PDI
Sbjct: 214 PDI 216
Score = 46.0 bits (104), Expect = 0.001
Identities = 24/61 (39%), Positives = 37/61 (60%)
Frame = +2
Query: 329 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVV 508
+ +I+ V +KG I T + S NVA+R ELD+YA + KS PG+ + +DID+V
Sbjct: 56 LESIRETRVAIKGPIGTPVGTGF-RSVNVAIRKELDLYANLRPAKSLPGIKSPFQDIDLV 114
Query: 509 L 511
+
Sbjct: 115 V 115
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 83.4 bits (197), Expect = 5e-15
Identities = 44/83 (53%), Positives = 59/83 (71%), Gaps = 2/83 (2%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKV-VTADNSERVARFAFEFAKKNGRKKVTTVH-KAN 684
IR+NTEGEYA EHE V GV+ES +V +T S+R+A++AFE+A + RKKVT VH
Sbjct: 100 IRENTEGEYAGREHEVVPGVIESFQVTMTKFWSDRIAKYAFEYAHFSKRKKVTAVHNNGK 159
Query: 685 IMKLSDGLFLETSRRLAKEYPDI 753
KL+D FLE+ + +AK YP+I
Sbjct: 160 YEKLADAFFLESCQEVAKMYPNI 182
Score = 32.7 bits (71), Expect = 10.0
Identities = 11/30 (36%), Positives = 23/30 (76%)
Frame = +2
Query: 422 RNELDMYAYILNCKSYPGVATRHKDIDVVL 511
R ELD++A +++C + G +RH+++D+V+
Sbjct: 70 RKELDLFASLVDCFNLNGQPSRHENVDIVV 99
>UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=29; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Rickettsia felis (Rickettsia azadi)
Length = 483
Score = 83.4 bits (197), Expect = 5e-15
Identities = 38/81 (46%), Positives = 55/81 (67%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR+N E YA +E+ + + ES+K+++ E++ R+AFE+A KN RKKVT + K NIM
Sbjct: 120 IRENEEDLYAGIEYRQTHNMYESIKLISHTGCEKIIRYAFEYAVKNNRKKVTCLSKDNIM 179
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
K SDG+F + +AKEYP I
Sbjct: 180 KFSDGVFHKIFNEIAKEYPQI 200
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 81.4 bits (192), Expect = 2e-14
Identities = 37/80 (46%), Positives = 54/80 (67%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR EG+Y+ +EH V GV++++KV T + R+A F F +A KN RK++T HKANIM
Sbjct: 174 IRDQMEGDYSGIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIM 233
Query: 691 KLSDGLFLETSRRLAKEYPD 750
+++DG FLE R A ++ D
Sbjct: 234 RMTDGNFLEAMRAEADKHVD 253
Score = 40.3 bits (90), Expect = 0.050
Identities = 22/84 (26%), Positives = 43/84 (51%)
Frame = +2
Query: 260 APIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDM 439
API+++V D D+DD + +++ N VG+KG ++++ + R +
Sbjct: 97 APIEWDVHDEFKAKDSDDVSPEVLKSLRANKVGIKGPVDSRHWQRQI-------RKQFAQ 149
Query: 440 YAYILNCKSYPGVATRHKDIDVVL 511
+AY+ C G+ + + D DVV+
Sbjct: 150 FAYVSLCSHIEGLDSPYGDFDVVI 173
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 79.4 bits (187), Expect = 9e-14
Identities = 36/84 (42%), Positives = 55/84 (65%), Gaps = 2/84 (2%)
Frame = +1
Query: 508 FIRQNTEGEYAMLEH--ESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKA 681
F R+NTEGEY + + + KV+T SER+ R AF++A++N +V+ V KA
Sbjct: 133 FFRENTEGEYVLGSKGFNVTDDLAVDFKVITTQGSERIIRLAFDYARRNNINRVSVVTKA 192
Query: 682 NIMKLSDGLFLETSRRLAKEYPDI 753
N++K +DG FLE +R ++KEYP+I
Sbjct: 193 NVVKTTDGKFLEIARAISKEYPEI 216
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 79.0 bits (186), Expect = 1e-13
Identities = 35/81 (43%), Positives = 53/81 (65%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
+R+N E YA +EH V +++K+++ SE++ RFAFE A+ GRKKV K+NIM
Sbjct: 136 VRENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIM 195
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
KL++G ++A+EYPDI
Sbjct: 196 KLAEGTLKRAFEQVAQEYPDI 216
>UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n=9;
Methanococcales|Rep: Threo-isocitrate dehydrogenase
[NAD] - Methanococcus jannaschii
Length = 347
Score = 77.8 bits (183), Expect = 3e-13
Identities = 37/78 (47%), Positives = 51/78 (65%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR+NTE Y E N + +V+T SER+ RFAFE+A KN RKKV+ +HKAN++
Sbjct: 127 IRENTEDLYVGRERLE-NDTAIAERVITRKGSERIIRFAFEYAIKNNRKKVSCIHKANVL 185
Query: 691 KLSDGLFLETSRRLAKEY 744
+++DGLFLE + K Y
Sbjct: 186 RITDGLFLEVFNEIKKHY 203
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 75.4 bits (177), Expect = 1e-12
Identities = 34/81 (41%), Positives = 52/81 (64%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR+N E YA +E+ ES+K+++ SE++ RFAFE+A KN RK ++ K NIM
Sbjct: 120 IRENEEDLYAGIEYHHTADTYESVKLISRSGSEKIIRFAFEYALKNNRKTISCFSKDNIM 179
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
K +DG+F +T +A +Y +I
Sbjct: 180 KFTDGIFHKTFNEIASQYSNI 200
>UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Aspergillus oryzae|Rep: Isocitrate/isopropylmalate
dehydrogenase - Aspergillus oryzae
Length = 350
Score = 74.5 bits (175), Expect = 3e-12
Identities = 37/82 (45%), Positives = 57/82 (69%), Gaps = 1/82 (1%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVV-ESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANI 687
+R+ TE Y E +G E++K VT S +V+++AFE+A+K+GRKKV+ +HKAN+
Sbjct: 127 MREITEDTYIGWEKPLEDGAAAEAIKRVTRSASWKVSQYAFEYARKHGRKKVSCLHKANV 186
Query: 688 MKLSDGLFLETSRRLAKEYPDI 753
+ +DGLFL T + +A+ YPDI
Sbjct: 187 LHETDGLFLRTFQEVARLYPDI 208
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 74.5 bits (175), Expect = 3e-12
Identities = 33/81 (40%), Positives = 55/81 (67%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
+R+NTE Y E + G V + +++T S R+++FAF++A+K G +KVT VHKAN++
Sbjct: 113 VRENTEDLYVGDEEYTPEGAV-AKRIITRTASRRISQFAFQYAQKEGMQKVTAVHKANVL 171
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
K +DG+F + ++A EYP +
Sbjct: 172 KKTDGIFRDEFYKVASEYPQM 192
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 74.5 bits (175), Expect = 3e-12
Identities = 39/85 (45%), Positives = 56/85 (65%), Gaps = 4/85 (4%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFA---KKNGRK-KVTTVHK 678
+R+NTEG Y +E E G+ + +V+T ER+ RFAF A KK G++ KVT HK
Sbjct: 111 VRENTEGLYKGIEAEIDEGITIATRVITEKACERIFRFAFNLARERKKMGKEGKVTCAHK 170
Query: 679 ANIMKLSDGLFLETSRRLAKEYPDI 753
AN++KL+DGLF + ++A+EY DI
Sbjct: 171 ANVLKLTDGLFKKIFYKVAEEYDDI 195
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 73.7 bits (173), Expect = 4e-12
Identities = 36/76 (47%), Positives = 49/76 (64%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
+R+NTE Y EH +GV MK++T SER+A+ FA + RKKVT VHKAN+M
Sbjct: 116 VRENTEDLYKGFEHIVSDGVAVGMKIITRFASERIAKVGLNFALRR-RKKVTCVHKANVM 174
Query: 691 KLSDGLFLETSRRLAK 738
+++DGLF E R + K
Sbjct: 175 RITDGLFAEACRSVLK 190
Score = 33.5 bits (73), Expect = 5.7
Identities = 14/33 (42%), Positives = 22/33 (66%)
Frame = +2
Query: 413 VALRNELDMYAYILNCKSYPGVATRHKDIDVVL 511
V LR DMYA I KS PG+ T++ ++D+++
Sbjct: 83 VKLRQIYDMYANIRPAKSIPGIDTKYGNVDILI 115
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 72.9 bits (171), Expect = 8e-12
Identities = 33/82 (40%), Positives = 58/82 (70%), Gaps = 1/82 (1%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAK-KNGRKKVTTVHKANI 687
+R+NTE Y E + V ++++++ S+R+A++AFE AK +N +KKVT VHK+N+
Sbjct: 115 VRENTEDLYTGKEFSLGDSSV-ALRIISEQASKRIAKYAFETAKMRNDKKKVTCVHKSNV 173
Query: 688 MKLSDGLFLETSRRLAKEYPDI 753
M+++DG+F + ++K+YPDI
Sbjct: 174 MRVTDGMFAKACTEVSKDYPDI 195
Score = 33.9 bits (74), Expect = 4.3
Identities = 18/43 (41%), Positives = 25/43 (58%), Gaps = 1/43 (2%)
Frame = +2
Query: 413 VALRNELDMYAYILNCKSYPGVATRHKDID-VVLSDRTQKVNT 538
V LR LD+YA I KSYP + DID V++ + T+ + T
Sbjct: 82 VVLRRMLDLYANIRPAKSYPHMPALRDDIDMVIVRENTEDLYT 124
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 71.3 bits (167), Expect = 2e-11
Identities = 34/85 (40%), Positives = 53/85 (62%), Gaps = 5/85 (5%)
Frame = +1
Query: 511 IRQNTEGEYAMLEH-----ESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVH 675
+R+N EG Y EH + + V + + T S R+++FAF++A +N R+KVT VH
Sbjct: 122 VRENLEGLYVGHEHYVPIGDDAHAVAMATGINTRAGSRRISKFAFDYAVRNNRRKVTIVH 181
Query: 676 KANIMKLSDGLFLETSRRLAKEYPD 750
KAN++K GLFLET++++ Y D
Sbjct: 182 KANVLKALTGLFLETAKQVGLNYAD 206
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 70.5 bits (165), Expect = 4e-11
Identities = 33/81 (40%), Positives = 51/81 (62%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IR+N E Y+ +EH+ E +K+ T SE++ +AF +A+ + RKKVT K NIM
Sbjct: 123 IRENEEDTYSGVEHKLSEDTHECVKISTRSASEKICAYAFNYARAHNRKKVTCFVKDNIM 182
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
K++DG+ + ++AK YPDI
Sbjct: 183 KMTDGILHASFDKVAKGYPDI 203
Score = 39.9 bits (89), Expect = 0.066
Identities = 24/60 (40%), Positives = 33/60 (55%), Gaps = 1/60 (1%)
Frame = +2
Query: 335 TIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSY-PGVATRHKDIDVVL 511
+I R + LK T + + S NVALR L +Y + C SY P V T+H D+DVV+
Sbjct: 64 SISRTRLLLKAPTMTPQGSGH-KSLNVALRQRLGLYVNVRPCVSYFPVVGTKHPDLDVVI 122
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 67.7 bits (158), Expect = 3e-10
Identities = 32/81 (39%), Positives = 53/81 (65%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
+R+ TEG Y E + + V +++ +T S ++AR+AFE AK+ G V +HK+NI+
Sbjct: 119 VREGTEGLYIGEEIQLTDDVSIAIRKITRTASGKIARYAFEEAKRRGYDTVVPIHKSNIL 178
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
KL+ G FLE ++A++YP+I
Sbjct: 179 KLTCGSFLEEVEKVAQDYPNI 199
>UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenase
oxidoreductase protein; n=1; Ralstonia solanacearum|Rep:
Probable 3-isopropylmalate dehydrogenase oxidoreductase
protein - Ralstonia solanacearum (Pseudomonas
solanacearum)
Length = 365
Score = 62.9 bits (146), Expect = 8e-09
Identities = 29/59 (49%), Positives = 43/59 (72%)
Frame = +1
Query: 577 SMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEYPDI 753
S++ +T SER+AR AFE A K +KKVT +HKAN ++DGLFLE R +A+++P++
Sbjct: 154 SLRKITRHCSERIARRAFELAMKR-KKKVTAIHKANSFHMTDGLFLECVRDVARDFPEV 211
>UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
2 - Pyrococcus furiosus
Length = 355
Score = 62.9 bits (146), Expect = 8e-09
Identities = 36/86 (41%), Positives = 48/86 (55%), Gaps = 4/86 (4%)
Frame = +1
Query: 508 FIRQNTEGEYA----MLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVH 675
FIR+NTEG YA L + + V + T ER RFAFE+AK GRKKVT V
Sbjct: 124 FIRENTEGLYAGAGGFLRKGTPHEVAIQEMINTRFGVERTIRFAFEYAKTKGRKKVTLVD 183
Query: 676 KANIMKLSDGLFLETSRRLAKEYPDI 753
KAN++ + L+ + +A EY +I
Sbjct: 184 KANVLTYAHDLWQRVFKEVASEYQEI 209
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 62.5 bits (145), Expect = 1e-08
Identities = 27/69 (39%), Positives = 42/69 (60%)
Frame = +1
Query: 547 EHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSR 726
E V S++V+T + +V R A + A+ RKK+T VHK + KL G+F++T+
Sbjct: 145 EFRPTEDVTISVRVITVEGCRKVVRAALDIARSRPRKKLTLVHKNTVFKLGCGMFVDTAY 204
Query: 727 RLAKEYPDI 753
+AKEYPD+
Sbjct: 205 EVAKEYPDV 213
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 60.9 bits (141), Expect = 3e-08
Identities = 33/83 (39%), Positives = 48/83 (57%), Gaps = 4/83 (4%)
Frame = +1
Query: 508 FIRQNTEGEYA----MLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVH 675
F+R+NTEG YA L + + + T ERV RFAFE+AK++GRKKVT V
Sbjct: 125 FVRENTEGLYAGAGGFLRKGTPQEIAVQEMINTRFGVERVIRFAFEYAKRSGRKKVTLVD 184
Query: 676 KANIMKLSDGLFLETSRRLAKEY 744
KAN++ + L+ +++EY
Sbjct: 185 KANVLTYAHDLWERVFAEVSQEY 207
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 60.1 bits (139), Expect = 6e-08
Identities = 29/70 (41%), Positives = 46/70 (65%)
Frame = +1
Query: 502 CCFIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKA 681
C F+R+N E Y E++ V V ++KV+T + RVAR A ++A+ R++VT VHKA
Sbjct: 77 CVFVRENVEDVYVGAEYK-VGDVAIALKVITEKGTRRVARMARKYAEMR-RRRVTIVHKA 134
Query: 682 NIMKLSDGLF 711
N++++ DG F
Sbjct: 135 NVLRVVDGFF 144
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 58.8 bits (136), Expect = 1e-07
Identities = 35/85 (41%), Positives = 48/85 (56%), Gaps = 7/85 (8%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNG-------VVESMKVVTADNSERVARFAFEFAKKNGRKKVTT 669
+R+NTEG YA E NG V S++ +T ER+A A A K R+ +T
Sbjct: 134 VRENTEGFYADRNMEQGNGEMLVTPDVAISLRRITRACCERIAHAACRLAMKR-RRHLTI 192
Query: 670 VHKANIMKLSDGLFLETSRRLAKEY 744
VHKAN++K+ DG+FL+ R AK Y
Sbjct: 193 VHKANVLKIGDGMFLDICRAAAKGY 217
>UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|Rep:
Tartrate dehydrogenase - Bacillus cereus subsp.
cytotoxis NVH 391-98
Length = 364
Score = 56.4 bits (130), Expect = 7e-07
Identities = 32/86 (37%), Positives = 49/86 (56%), Gaps = 4/86 (4%)
Frame = +1
Query: 508 FIRQNTEGEYA----MLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVH 675
FIR+N+EGEYA L + VV V + +ER+ R+AFE A+K RK +T++
Sbjct: 129 FIRENSEGEYAGAGDWLYKGKEHEVVLQNSVFSRKGTERIIRYAFEIARKE-RKSLTSIS 187
Query: 676 KANIMKLSDGLFLETSRRLAKEYPDI 753
K N + S + + ++KEYPD+
Sbjct: 188 KGNALNYSMVFWDQIFEEISKEYPDV 213
>UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8;
Eutheria|Rep: Isocitrate dehydrogenase 3 gamma - Homo
sapiens (Human)
Length = 88
Score = 56.0 bits (129), Expect = 9e-07
Identities = 23/49 (46%), Positives = 35/49 (71%), Gaps = 3/49 (6%)
Frame = +3
Query: 120 HKTP---VIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYS 257
H+ P + +Q + P A+YGGRH VTM+PG GIGPE M +V+ +F+++
Sbjct: 5 HEVPSRNIFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHA 53
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 55.6 bits (128), Expect = 1e-06
Identities = 34/89 (38%), Positives = 51/89 (57%), Gaps = 8/89 (8%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNG-------VVESMKVVTADNSERVARFAFEFAKKNGRKKVTT 669
+R+NTEG YA + +G V ++ VVT ER+A AF A+ GR VT
Sbjct: 133 VRENTEGLYADRNMFAGSGEFMPTPDVALAVGVVTRKACERIAHTAFALARTRGRH-VTI 191
Query: 670 VHKANIMKLSDGLFLETSRRLA-KEYPDI 753
VHKAN++ ++ GLF + R + ++YPD+
Sbjct: 192 VHKANVLSMTTGLFRDVCREVGQRDYPDV 220
>UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subunit;
n=1; Pan troglodytes|Rep: Isocitrate dehydrogenase 3
gamma subunit - Pan troglodytes (Chimpanzee)
Length = 165
Score = 54.8 bits (126), Expect = 2e-06
Identities = 21/33 (63%), Positives = 27/33 (81%)
Frame = +3
Query: 156 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKY 254
P A+YGGRH VTM+PG GIGPE M +V+ +F+Y
Sbjct: 105 PSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRY 137
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 52.4 bits (120), Expect = 1e-05
Identities = 25/86 (29%), Positives = 52/86 (60%), Gaps = 3/86 (3%)
Frame = +2
Query: 263 PIDFEVVDIDPT--MDNDDDVQYAITTIKRNGVGLKGNIETKSE-AAYVTSRNVALRNEL 433
P++F+ + M +++ ++ ++++K N V + G I T E + S ++ LR +L
Sbjct: 77 PVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKL 136
Query: 434 DMYAYILNCKSYPGVATRHKDIDVVL 511
D++A +++ KS PG TRH ++D+V+
Sbjct: 137 DLFANVVHVKSLPGYMTRHNNLDLVI 162
Score = 37.1 bits (82), Expect = 0.46
Identities = 15/26 (57%), Positives = 19/26 (73%)
Frame = +3
Query: 174 GRHAVTMLPGGGIGPECMGYVRDIFK 251
G VTMLPG G+GPE M V+++FK
Sbjct: 47 GSFPVTMLPGDGVGPELMHAVKEVFK 72
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 52.4 bits (120), Expect = 1e-05
Identities = 24/54 (44%), Positives = 33/54 (61%)
Frame = +1
Query: 580 MKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKE 741
+K ++ + SER+ RFA FA N R VT VHK N++K +DG F LAK+
Sbjct: 199 IKNISKEGSERLTRFALNFALNNNRDSVTFVHKGNVLKFTDGAFKRWGFALAKK 252
>UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-isopropylmalate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 478
Score = 52.0 bits (119), Expect = 2e-05
Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 4/85 (4%)
Frame = +1
Query: 511 IRQNTEGEYA----MLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHK 678
+R+ TEG Y L + + + + V TA ERV R AF A++ RKK+T VHK
Sbjct: 258 VREGTEGPYTGNGGALRVGTPHEIATEVSVNTAFGVERVVRDAFARAQRRPRKKLTLVHK 317
Query: 679 ANIMKLSDGLFLETSRRLAKEYPDI 753
N++ + ++ ++++A EYP++
Sbjct: 318 TNVLVNAGAVWWRITQQVAAEYPEV 342
>UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2;
Deinococcus|Rep: Isocitrate dehydrogenase, putative -
Deinococcus radiodurans
Length = 333
Score = 51.6 bits (118), Expect = 2e-05
Identities = 24/70 (34%), Positives = 43/70 (61%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
+R+NT+G Y E + + V+T + S+R+ +FA + A K K++T VHK+N++
Sbjct: 119 VRENTQGLYVEQERRYGDTAIADT-VITREASDRIGKFAADLAMKRS-KRLTVVHKSNVL 176
Query: 691 KLSDGLFLET 720
++ GLF+ T
Sbjct: 177 PVTQGLFMNT 186
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 51.2 bits (117), Expect = 3e-05
Identities = 31/85 (36%), Positives = 47/85 (55%), Gaps = 4/85 (4%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNS----ERVARFAFEFAKKNGRKKVTTVHK 678
+R+N+EGEY+ + +G E + +A +S ERV R+AFE ++K R VT K
Sbjct: 129 VRENSEGEYSNIGGIFKSGTPEEFAIESAVHSRRGLERVIRYAFEASRKR-RNHVTLATK 187
Query: 679 ANIMKLSDGLFLETSRRLAKEYPDI 753
+N MK L+ +A EYPD+
Sbjct: 188 SNAMKFGMVLWDSVFEAIAMEYPDV 212
>UniRef50_Q1IMD5 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Acidobacteria bacterium Ellin345|Rep: 3-isopropylmalate
dehydrogenase - Acidobacteria bacterium (strain
Ellin345)
Length = 403
Score = 51.2 bits (117), Expect = 3e-05
Identities = 20/59 (33%), Positives = 39/59 (66%)
Frame = +1
Query: 577 SMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEYPDI 753
S++++T N++R+ AF+ AKK K VT K N+++ + G+ E ++++ K+YP+I
Sbjct: 187 SVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVAKQVQKQYPEI 245
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 51.2 bits (117), Expect = 3e-05
Identities = 27/85 (31%), Positives = 47/85 (55%), Gaps = 4/85 (4%)
Frame = +1
Query: 511 IRQNTEGEYAMLE----HESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHK 678
+R+NTEGEY+ L + N +V + T +R+ ++AF+ A+K RK VT+ K
Sbjct: 133 VRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAFDLAEKRERKHVTSATK 192
Query: 679 ANIMKLSDGLFLETSRRLAKEYPDI 753
+N M +S + + + +A YP +
Sbjct: 193 SNGMAISMPYWDKRTEAMAAHYPHV 217
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 50.8 bits (116), Expect = 4e-05
Identities = 22/56 (39%), Positives = 38/56 (67%)
Frame = +1
Query: 577 SMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEY 744
S+K ++ + + +AF++A N R+ VT++ KANIMK +DGL+ + +R +AK Y
Sbjct: 162 SIKPMSYQGTRDICNYAFKYAVDNKRQSVTSICKANIMKFTDGLWYDETRAVAKAY 217
Score = 41.1 bits (92), Expect = 0.029
Identities = 30/91 (32%), Positives = 45/91 (49%), Gaps = 2/91 (2%)
Frame = +2
Query: 245 IQILGAPIDFEVVDID-PTMDNDDDV-QYAITTIKRNGVGLKGNIETKSEAAYVTSRNVA 418
+ G ID++V + ++ + V + +I+ N + LK I T + S NV
Sbjct: 24 VDATGVKIDWDVQECGIEVIEAEGGVPDRVMDSIRANKIALKAPITTPIGKGF-RSVNVF 82
Query: 419 LRNELDMYAYILNCKSYPGVATRHKDIDVVL 511
LR EL +YA I CK+Y GV T D +V L
Sbjct: 83 LRQELGLYACIRPCKTYKGVRTYFADSNVDL 113
>UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3;
Proteobacteria|Rep: Tartrate dehydrogenase -
Burkholderia xenovorans (strain LB400)
Length = 364
Score = 50.4 bits (115), Expect = 5e-05
Identities = 26/85 (30%), Positives = 47/85 (55%), Gaps = 4/85 (4%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNG----VVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHK 678
+R+N+EGEY+ + G + ++T ER+ RFAF A+ RK +T + K
Sbjct: 130 VRENSEGEYSGVGGRVHQGHPIEAATDVSILTRAGVERIMRFAFRLAQSRPRKLLTVITK 189
Query: 679 ANIMKLSDGLFLETSRRLAKEYPDI 753
+N + + L+ E + ++KE+PD+
Sbjct: 190 SNAQRHAMVLWDEIALEISKEFPDV 214
>UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Corynebacterium efficiens
Length = 340
Score = 50.4 bits (115), Expect = 5e-05
Identities = 28/85 (32%), Positives = 45/85 (52%), Gaps = 4/85 (4%)
Frame = +1
Query: 511 IRQNTEGEYA----MLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHK 678
+R+ TEG Y + + + V T +ERV R+AFE A+ R+ +T VHK
Sbjct: 121 VREGTEGAYTGNGGAIRVGTPHETANETSVNTRYGAERVIRYAFELAQSR-RRHLTLVHK 179
Query: 679 ANIMKLSDGLFLETSRRLAKEYPDI 753
N++ GL+ T +A+EYP++
Sbjct: 180 TNVLVHGGGLWQRTVDEVAREYPEV 204
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 50.0 bits (114), Expect = 6e-05
Identities = 33/89 (37%), Positives = 48/89 (53%), Gaps = 8/89 (8%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESV--NGVVESMKVVTADNSERVARFAFEFAK------KNGRKKVT 666
+R+N+EG YA ++ V V T ER+ RFAFE A+ K+GR++VT
Sbjct: 129 VRENSEGLYAARGAGALLREEVAVDTLVQTRKGVERIVRFAFELARTRNGSPKDGRRRVT 188
Query: 667 TVHKANIMKLSDGLFLETSRRLAKEYPDI 753
KAN+++ + F +AKEYPDI
Sbjct: 189 CCDKANVLR-TYAFFRAVFDEVAKEYPDI 216
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 49.2 bits (112), Expect = 1e-04
Identities = 31/91 (34%), Positives = 50/91 (54%), Gaps = 10/91 (10%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVE-SMKVVTADNSERVARFAFEFAK-----KNGRK----K 660
+R+NTE YA E +G + +V+T S R+ R A + A+ +NG +
Sbjct: 124 VRENTEDVYAGRERVEDDGATAIAERVITRRASARIMRVACDLARARRSARNGSDAPPGR 183
Query: 661 VTTVHKANIMKLSDGLFLETSRRLAKEYPDI 753
VT VHKAN+++ + GLF + +A+ YPD+
Sbjct: 184 VTVVHKANVLRETCGLFRSVALEVAQAYPDL 214
>UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=73; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Staphylococcus epidermidis (strain ATCC 35984 /
RP62A)
Length = 422
Score = 49.2 bits (112), Expect = 1e-04
Identities = 25/58 (43%), Positives = 36/58 (62%), Gaps = 1/58 (1%)
Frame = +1
Query: 580 MKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLA-KEYPD 750
+K V+ + +ER+ R A ++A N RK VT VHK NIMK ++G F + LA E+ D
Sbjct: 188 IKPVSKEGTERLVRAAIQYALDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAHNEFGD 245
Score = 35.9 bits (79), Expect = 1.1
Identities = 22/67 (32%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Frame = +2
Query: 320 QYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---RH 490
Q + TIK + +KG + T + S NVALR ELD++ + + + GV + R
Sbjct: 76 QETLETIKEYLIAVKGPLTTPIGGG-IRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRP 134
Query: 491 KDIDVVL 511
+D+D+V+
Sbjct: 135 EDVDMVI 141
>UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila
melanogaster|Rep: IP13250p - Drosophila melanogaster
(Fruit fly)
Length = 475
Score = 48.8 bits (111), Expect = 1e-04
Identities = 23/54 (42%), Positives = 35/54 (64%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTV 672
I QN G + LE+ V GVVE++ VV+ +++ R+AF+ A K GRK+VT +
Sbjct: 165 IGQNNMGIFNELEYSPVEGVVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLI 218
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 48.8 bits (111), Expect = 1e-04
Identities = 27/84 (32%), Positives = 46/84 (54%)
Frame = +1
Query: 502 CCFIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKA 681
C R+ TEG Y +E + + +++ +T S R+ A ++A K KK+ V K
Sbjct: 117 CVCFREATEGLYTGVEAKITDDAAIAIRKITRQGSRRLIDSAVDWANKFNMKKMVAVTKR 176
Query: 682 NIMKLSDGLFLETSRRLAKEYPDI 753
NI+K +DG+F + +++ A E DI
Sbjct: 177 NILKQTDGIFWDETQK-AVEGTDI 199
>UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp -
Pasteurella multocida
Length = 415
Score = 48.4 bits (110), Expect = 2e-04
Identities = 21/55 (38%), Positives = 35/55 (63%)
Frame = +1
Query: 580 MKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEY 744
+K V+ ++R+ R A ++ N RK +T VHK NIMK ++G F E ++A+E+
Sbjct: 198 IKPVSKQGTQRLVRAALQYVIDNDRKSLTLVHKGNIMKFTEGAFKEWGYQVAQEF 252
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 47.6 bits (108), Expect = 3e-04
Identities = 28/85 (32%), Positives = 45/85 (52%), Gaps = 4/85 (4%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGV----VESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHK 678
+R+NTEGEY+ + G V V T +ERV +FAFE A++ K++T K
Sbjct: 133 VRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQRRA-KRLTVATK 191
Query: 679 ANIMKLSDGLFLETSRRLAKEYPDI 753
+N + +S + + +A YPD+
Sbjct: 192 SNGIAISMPWWDARAAEMAARYPDV 216
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 46.8 bits (106), Expect = 6e-04
Identities = 21/54 (38%), Positives = 35/54 (64%)
Frame = +1
Query: 580 MKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKE 741
+K ++ + +ER+ R A E+A N + VT VHK NIMK ++G F++ LA++
Sbjct: 207 VKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQK 260
>UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=15; Archaea|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Archaeoglobus fulgidus
Length = 412
Score = 46.8 bits (106), Expect = 6e-04
Identities = 21/54 (38%), Positives = 34/54 (62%)
Frame = +1
Query: 580 MKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKE 741
+K ++ ++R+ R A +A +N RK VT VHK NIMK ++G F + +AK+
Sbjct: 191 IKPISEFATKRLVRMAIRYAIENNRKSVTLVHKGNIMKYTEGAFRDWGYEVAKQ 244
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 46.4 bits (105), Expect = 8e-04
Identities = 31/98 (31%), Positives = 52/98 (53%)
Frame = +1
Query: 445 LHSEL*ILPWRCDQT*GH*CCFIRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARF 624
L++ L I+P D + G +R+NTEG YA + + +++T + + R+A+F
Sbjct: 91 LYANLRIIP---DLSNGKEIVIVRENTEGLYAR-DGIGFSDRAIDFRIITLEGARRIAKF 146
Query: 625 AFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAK 738
A AK+ +T VHKAN++K D F E +A+
Sbjct: 147 AINLAKER-NSFITFVHKANVLK-GDRFFREIVLEIAE 182
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 46.4 bits (105), Expect = 8e-04
Identities = 25/70 (35%), Positives = 40/70 (57%)
Frame = +1
Query: 532 EYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLF 711
E A + H+ G+ +K ++ S+R+ R A ++A N R VT VHK NIMK ++G F
Sbjct: 226 EIADVIHDGPVGI--GVKPISEFGSKRLIREAIDYALANDRDSVTLVHKGNIMKFTEGAF 283
Query: 712 LETSRRLAKE 741
+ +A+E
Sbjct: 284 RDWGYEVAEE 293
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 46.0 bits (104), Expect = 0.001
Identities = 27/79 (34%), Positives = 47/79 (59%), Gaps = 5/79 (6%)
Frame = +1
Query: 511 IRQNTEGEYA----MLEHESV-NGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVH 675
+R+N E Y +L S+ + V +++ + + RVA+ A E+AK R KVT VH
Sbjct: 115 VRENIEDLYVGAENLLPQTSLGHKVAVGLRLASERETRRVAKVAAEYAKAR-RNKVTIVH 173
Query: 676 KANIMKLSDGLFLETSRRL 732
KAN+M+++ GLF + ++ +
Sbjct: 174 KANVMRVTCGLFRDVAKEV 192
>UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 230
Score = 45.6 bits (103), Expect = 0.001
Identities = 27/70 (38%), Positives = 35/70 (50%)
Frame = -2
Query: 717 LQE*AIG*LHDVGFVNRRHLLPAVFLGEFEGEPGHPL*VVSCHHFH*LDHTIHGFVFQHS 538
L E I HD+G V+ L V LG+ + + G L H H L+HT VFQ
Sbjct: 32 LTEQTISQFHDIGLVDGGDQLTVVLLGKVKCKLGDSLGFEPGHDLHRLNHTRVRLVFQSR 91
Query: 537 VFTFCVLSDK 508
+FTF V SD+
Sbjct: 92 IFTFSVFSDE 101
>UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5;
Euryarchaeota|Rep: 2-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 324
Score = 45.6 bits (103), Expect = 0.001
Identities = 29/75 (38%), Positives = 44/75 (58%)
Frame = +1
Query: 514 RQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMK 693
R+N+E Y +E E S++V+T SER+AR A K G K+T VHK+N++K
Sbjct: 112 RENSEDLYMGIE-EITGDEARSVRVITRKASERIARAA---CSKPGIGKLTIVHKSNVLK 167
Query: 694 LSDGLFLETSRRLAK 738
+D LF + ++AK
Sbjct: 168 -ADELFKDACAQVAK 181
>UniRef50_Q44471 Cluster: Probable tartrate
dehydrogenase/decarboxylase ttuC; n=66; cellular
organisms|Rep: Probable tartrate
dehydrogenase/decarboxylase ttuC - Agrobacterium vitis
(Rhizobium vitis)
Length = 364
Score = 44.8 bits (101), Expect = 0.002
Identities = 25/85 (29%), Positives = 46/85 (54%), Gaps = 4/85 (4%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESM----KVVTADNSERVARFAFEFAKKNGRKKVTTVHK 678
+R+N+EGEY+ + G+ E + + T R+ R+AF+ A+ RK +T V K
Sbjct: 130 VRENSEGEYSGHGGRAHRGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQARPRKLLTVVTK 189
Query: 679 ANIMKLSDGLFLETSRRLAKEYPDI 753
+N + ++ E + +A E+PD+
Sbjct: 190 SNAQRHGMVMWDEIAAEVATEFPDV 214
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 44.8 bits (101), Expect = 0.002
Identities = 22/55 (40%), Positives = 30/55 (54%)
Frame = +2
Query: 329 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHK 493
+T IK GV +KG + T + S NVALR D+Y + C+ YPG + HK
Sbjct: 89 LTAIKEYGVAIKGPLTTPVGGG-IRSLNVALRQIFDLYTCVRPCRYYPGTPSPHK 142
Score = 36.7 bits (81), Expect = 0.61
Identities = 20/54 (37%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Frame = +1
Query: 580 MKVVTADNSERVARFAFEFAKK--NGRKKVTTVHKANIMKLSDGLFLETSRRLA 735
+K ++ S+R+ R A AK+ ++ VT VHK NIMK ++G F + LA
Sbjct: 203 IKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKGNIMKFTEGPFRDWGYELA 256
>UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria
bacteriumYellowstone A-Prime)
Length = 381
Score = 44.4 bits (100), Expect = 0.003
Identities = 22/49 (44%), Positives = 35/49 (71%)
Frame = +1
Query: 607 ERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEYPDI 753
+R+AR AFE A+K R+K+ +V KAN++++S L+ E +A EYPD+
Sbjct: 178 DRIARVAFELARKR-RRKLCSVDKANVLEVSQ-LWRERVTAIAAEYPDV 224
>UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2;
Thermoplasmatales|Rep: Isocitrate dehydrogenase [NADP] -
Picrophilus torridus
Length = 392
Score = 44.0 bits (99), Expect = 0.004
Identities = 20/58 (34%), Positives = 35/58 (60%), Gaps = 1/58 (1%)
Frame = +1
Query: 580 MKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLA-KEYPD 750
+K ++ ++R+ R A ++A N KK+T +HK N+MK ++G F E + A E+ D
Sbjct: 180 IKPMSRYKTQRITRLAVKYAMDNNLKKITIMHKGNVMKYTEGAFREWAYETALNEFSD 237
>UniRef50_Q9FMT1 Cluster: 3-isopropylmalate dehydrogenase 3,
chloroplast precursor; n=186; cellular organisms|Rep:
3-isopropylmalate dehydrogenase 3, chloroplast precursor
- Arabidopsis thaliana (Mouse-ear cress)
Length = 409
Score = 41.9 bits (94), Expect = 0.016
Identities = 26/68 (38%), Positives = 40/68 (58%)
Frame = +1
Query: 550 HESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRR 729
+E+ V S ++ A +R+AR AFE A+K R K+ +V KAN++ S L+ +
Sbjct: 195 NENGEEVGVSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASI-LWRKRVTA 252
Query: 730 LAKEYPDI 753
LA EYPD+
Sbjct: 253 LASEYPDV 260
>UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 364
Score = 41.5 bits (93), Expect = 0.022
Identities = 31/88 (35%), Positives = 48/88 (54%), Gaps = 7/88 (7%)
Frame = +1
Query: 511 IRQNTEGEY------AMLEHESVNGVVESMKVVTADNSERVARFAFEFA-KKNGRKKVTT 669
+R++TEG + A LE + ++ +T SERV R AFE A +++G+K VT
Sbjct: 132 VRESTEGLFYGRDAIADLEADEATNLLR----ITRSASERVCRLAFETARRRDGKKTVTL 187
Query: 670 VHKANIMKLSDGLFLETSRRLAKEYPDI 753
+ KAN++ S F +AKE+ DI
Sbjct: 188 IDKANVLS-SMVYFRHVFDEVAKEFLDI 214
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 41.5 bits (93), Expect = 0.022
Identities = 21/75 (28%), Positives = 44/75 (58%), Gaps = 3/75 (4%)
Frame = +2
Query: 263 PIDFEVVDIDPT--MDNDDDVQYAITTIKRNGVGLKGNIETKSE-AAYVTSRNVALRNEL 433
P++F+ + M +++ ++ ++++K N V + G I T E + S ++ LR +L
Sbjct: 45 PVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKL 104
Query: 434 DMYAYILNCKSYPGV 478
D++A +++ KS PGV
Sbjct: 105 DLFANVIHVKSLPGV 119
Score = 37.1 bits (82), Expect = 0.46
Identities = 15/26 (57%), Positives = 19/26 (73%)
Frame = +3
Query: 174 GRHAVTMLPGGGIGPECMGYVRDIFK 251
G VTMLPG G+GPE M V+++FK
Sbjct: 15 GAFPVTMLPGDGVGPELMHAVKEVFK 40
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 41.5 bits (93), Expect = 0.022
Identities = 25/89 (28%), Positives = 45/89 (50%), Gaps = 9/89 (10%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNG-----VVESMKVVTADNSERVARFAFEFAKKN----GRKKV 663
+R+NTE Y +E ++ V ++ K ++ + R+A A + A K G+ +
Sbjct: 142 VRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIALKRLQTRGQATL 201
Query: 664 TTVHKANIMKLSDGLFLETSRRLAKEYPD 750
T HK+N++ SDGLF E + + + D
Sbjct: 202 TVTHKSNVLSQSDGLFREICKEVYESNKD 230
>UniRef50_Q3ZXI7 Cluster: 3-isopropylmalate dehydrogenase; n=66;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Dehalococcoides sp. (strain CBDB1)
Length = 365
Score = 41.5 bits (93), Expect = 0.022
Identities = 30/87 (34%), Positives = 51/87 (58%), Gaps = 5/87 (5%)
Frame = +1
Query: 508 FIRQNTEGEYAMLEHE---SVNGVVESMKVVT-ADNS-ERVARFAFEFAKKNGRKKVTTV 672
FIR+ T G Y + + G+ ++ +T ++N ER+ R FE AK N +KK+ +V
Sbjct: 132 FIRELTGGVYFAKPKKRWTTPAGIRKATDSMTYSENEIERIVRVGFELAK-NRKKKLVSV 190
Query: 673 HKANIMKLSDGLFLETSRRLAKEYPDI 753
KAN++ LS L+ + +AK+YP++
Sbjct: 191 DKANVL-LSSRLWRQIVIEVAKDYPEV 216
>UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacillus cereus group|Rep: 3-isopropylmalate
dehydrogenase - Bacillus anthracis
Length = 354
Score = 41.5 bits (93), Expect = 0.022
Identities = 25/81 (30%), Positives = 40/81 (49%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
+R+ T G Y E + V ER+ AF+ A K +KKVT++ KAN++
Sbjct: 129 VRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSCAFQLASKR-KKKVTSIDKANVL 187
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
+ S L+ + +A YPD+
Sbjct: 188 E-SSKLWRIVTEEVALRYPDV 207
>UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=4; Chloroflexaceae|Rep: Isocitrate dehydrogenase,
NADP-dependent - Roseiflexus sp. RS-1
Length = 453
Score = 40.7 bits (91), Expect = 0.038
Identities = 24/70 (34%), Positives = 39/70 (55%), Gaps = 3/70 (4%)
Frame = +1
Query: 538 AMLEHESVNGVVE---SMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGL 708
++L + G VE +K V+ +ER+ A ++A + R+ VT VHK NIMK ++G
Sbjct: 201 SLLGNGDGEGAVEVGIGIKPVSRLGTERLVAAAIQYAITHRRRSVTFVHKGNIMKFTEGA 260
Query: 709 FLETSRRLAK 738
F + LA+
Sbjct: 261 FRDWGYALAE 270
>UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 380
Score = 40.3 bits (90), Expect = 0.050
Identities = 19/81 (23%), Positives = 42/81 (51%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
IRQ ++ + + + + VV+ + ++R+ ++F+ A +K +++V KAN++
Sbjct: 157 IRQMYSVKFGLDVETDSDEIAYQLGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVL 216
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
G + E A +YPD+
Sbjct: 217 TDIYGFWREVFTDTAAKYPDV 237
>UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenase;
n=1; Plesiocystis pacifica SIR-1|Rep: Probable
3-isopropylmalate dehydrogenase - Plesiocystis pacifica
SIR-1
Length = 368
Score = 39.9 bits (89), Expect = 0.066
Identities = 31/92 (33%), Positives = 45/92 (48%), Gaps = 11/92 (11%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNG----VVESMKVVTADNSERVARFAFEFAK-------KNGRK 657
IR+NTEG YA + G V +V+T E+V R AFE K K+G+
Sbjct: 127 IRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKGAPKDGKL 186
Query: 658 KVTTVHKANIMKLSDGLFLETSRRLAKEYPDI 753
+VT + K N++ LF + + EYP+I
Sbjct: 187 RVTAIIKDNVLH-GCQLFRDVFFEIGAEYPEI 217
>UniRef50_A6GJ83 Cluster: Isocitrate dehydrogenase; n=1;
Plesiocystis pacifica SIR-1|Rep: Isocitrate
dehydrogenase - Plesiocystis pacifica SIR-1
Length = 344
Score = 39.5 bits (88), Expect = 0.087
Identities = 24/79 (30%), Positives = 36/79 (45%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
+R T G Y S++ + S +RFAF A+ + T K I
Sbjct: 119 VRIATGGTYEDAGRRINRDTAVSIRAIERRPSVLASRFAFRLAQLRDSNVIAT-SKYTIQ 177
Query: 691 KLSDGLFLETSRRLAKEYP 747
K +DGLF E +R +A++YP
Sbjct: 178 KATDGLFQEAARGVARDYP 196
>UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Shewanella oneidensis
Length = 364
Score = 39.1 bits (87), Expect = 0.12
Identities = 21/48 (43%), Positives = 32/48 (66%)
Frame = +1
Query: 610 RVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEYPDI 753
R+AR AFE A + RKKVT+V KAN++ S L+ + +A ++PD+
Sbjct: 172 RIARIAFE-AARGRRKKVTSVDKANVLACS-VLWRQVVEEVAVDFPDV 217
>UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|Rep:
Tartrate dehydrogenase - Symbiobacterium thermophilum
Length = 359
Score = 38.7 bits (86), Expect = 0.15
Identities = 29/89 (32%), Positives = 46/89 (51%), Gaps = 8/89 (8%)
Frame = +1
Query: 511 IRQNTEGEYAMLE---HESV-NGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHK 678
IR+NTEGEY+ + H + + VV V T +ER+ R+A++ A RK++ K
Sbjct: 130 IRENTEGEYSNMGGRLHAGLPHEVVVQNTVFTRVGTERIIRYAYQLAANAPRKRLCGATK 189
Query: 679 AN----IMKLSDGLFLETSRRLAKEYPDI 753
+N M D +F E R E+P++
Sbjct: 190 SNGINYTMPYWDEIFNEIGER---EFPEV 215
>UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41;
Bacilli|Rep: 3-isopropylmalate dehydrogenase -
Streptococcus mutans
Length = 344
Score = 36.3 bits (80), Expect = 0.81
Identities = 24/81 (29%), Positives = 40/81 (49%)
Frame = +1
Query: 511 IRQNTEGEYAMLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKANIM 690
+R+ T G Y +H + +A R+ R AF A+ KKVT++ K N++
Sbjct: 130 VRELTGGIY-FGQHTLTENSACDINEYSASEIRRIMRKAFAIARGRS-KKVTSIDKQNVL 187
Query: 691 KLSDGLFLETSRRLAKEYPDI 753
S L+ + + +AKEY D+
Sbjct: 188 ATSK-LWRQIAEEVAKEYSDV 207
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 35.5 bits (78), Expect = 1.4
Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 8/84 (9%)
Frame = +1
Query: 514 RQNTEGEYA----MLEHESVNGVVESMKVVTADNSERVARFAFEFAKKNGRKKVTTVHKA 681
R+N EGEY+ L + + ++T E++ R A E+A+++G+ K+T+ K+
Sbjct: 129 RENAEGEYSDSGGRLYQQQPQEMTIQNTIMTRIGIEKIVRAACEYAQQHGKTKLTSATKS 188
Query: 682 NI----MKLSDGLFLETSRRLAKE 741
N MK D +T ++A E
Sbjct: 189 NAIIHSMKFWDEYTRKTVTQIAPE 212
>UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 106
Score = 35.5 bits (78), Expect = 1.4
Identities = 16/29 (55%), Positives = 19/29 (65%)
Frame = +3
Query: 141 KQKLIPKAQYGGRHAVTMLPGGGIGPECM 227
+Q + P A+YGG VTM PG G GPE M
Sbjct: 3 QQTIPPSAKYGGILTVTMSPGDGDGPELM 31
>UniRef50_Q6BHK1 Cluster: Similar to CA1897|IPF12002 Candida
albicans IPF12002; n=1; Debaryomyces hansenii|Rep:
Similar to CA1897|IPF12002 Candida albicans IPF12002 -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 333
Score = 35.1 bits (77), Expect = 1.9
Identities = 21/79 (26%), Positives = 37/79 (46%), Gaps = 1/79 (1%)
Frame = +2
Query: 200 WRRYRS*VHGIRSRHIQILGAPIDFEVVDIDPTMDNDDDVQYAITTI-KRNGVGLKGNIE 376
W Y+ H + + G+ IDF +VD++ MDND +YA++ +G +
Sbjct: 182 WTDYKYPTHFYQELALSEYGSDIDFMLVDVNKLMDNDFLAKYAVSNFPSMIYFTREGKFK 241
Query: 377 TKSEAAYVTSRNVALRNEL 433
T + TS + L ++L
Sbjct: 242 THHTLSQDTSVKILLNHDL 260
>UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyces
lasaliensis|Rep: Putative dehydrogenase - Streptomyces
lasaliensis
Length = 362
Score = 34.7 bits (76), Expect = 2.5
Identities = 25/85 (29%), Positives = 37/85 (43%), Gaps = 1/85 (1%)
Frame = +1
Query: 502 CCFIRQNTEGEYAMLEHESVNGVVESMKV-VTADNSERVARFAFEFAKKNGRKKVTTVHK 678
C +R+NTEG Y+ + + G E + V V V+R EFA R+ V V K
Sbjct: 139 CVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSR-VLEFAFSAARRSVCLVDK 197
Query: 679 ANIMKLSDGLFLETSRRLAKEYPDI 753
AN ++ L+ +P I
Sbjct: 198 ANAVRNGGQLWQRCWGEAVARHPHI 222
>UniRef50_UPI000065D57A Cluster: Putative polypeptide
N-acetylgalactosaminyltransferase-like protein 3 (EC
2.4.1.41) (Protein-UDP
acetylgalactosaminyltransferase-like protein 3)
(UDP-GalNAc:polypeptide
N-acetylgalactosaminyltransferase- like protein 3)
(Polypeptide GalNAc transferase-lik; n=1; Takifugu
rubripes|Rep: Putative polypeptide
N-acetylgalactosaminyltransferase-like protein 3 (EC
2.4.1.41) (Protein-UDP
acetylgalactosaminyltransferase-like protein 3)
(UDP-GalNAc:polypeptide
N-acetylgalactosaminyltransferase- like protein 3)
(Polypeptide GalNAc transferase-lik - Takifugu rubripes
Length = 605
Score = 34.3 bits (75), Expect = 3.3
Identities = 20/57 (35%), Positives = 28/57 (49%)
Frame = +3
Query: 252 YSVLLLTSKWWTLTQRWTMMMMSNML*RPLRGTVWG*RATLKPKVRQPM*RHAMWLS 422
Y V +LTS W +T+ M+MSN L R W R LK R P+ +W++
Sbjct: 117 YGVAILTSAWLKVTEEKKKMLMSNFLKR----LTWPFRECLKTLKRLPLCTWIIWMN 169
>UniRef50_Q89UQ9 Cluster: Aminobenzoyl-glutamate utilization
protein; n=5; Proteobacteria|Rep: Aminobenzoyl-glutamate
utilization protein - Bradyrhizobium japonicum
Length = 502
Score = 33.5 bits (73), Expect = 5.7
Identities = 18/64 (28%), Positives = 28/64 (43%)
Frame = +2
Query: 227 GIRSRHIQILGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTS 406
G R R +++L F+ D MDN D+ + TIK + L + E Y +
Sbjct: 7 GARRRVMKLLTIAASFDQEITDRNMDNRSDIWRGVDTIKARFIDLSDKVWGMPEVCYTEA 66
Query: 407 RNVA 418
R+ A
Sbjct: 67 RSAA 70
>UniRef50_Q8IC48 Cluster: Putative uncharacterized protein
PF07_0004; n=1; Plasmodium falciparum 3D7|Rep: Putative
uncharacterized protein PF07_0004 - Plasmodium
falciparum (isolate 3D7)
Length = 964
Score = 33.5 bits (73), Expect = 5.7
Identities = 22/81 (27%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Frame = +2
Query: 266 IDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNE-LDMY 442
I++E+++++ D+D+DV+Y + I+ + +E K E N L+ E L+
Sbjct: 172 IEYEIIEVEVDDDDDEDVEYEVIEIEVDDDEEVELLEDKEEKIEEVKENKQLKVESLEKK 231
Query: 443 AY-ILNCKSYPGVATRHKDID 502
I YP V K+ID
Sbjct: 232 PLEIKTTPKYPFVTDEQKEID 252
>UniRef50_Q7RM75 Cluster: Protein phosphatase; n=6; Plasmodium
(Vinckeia)|Rep: Protein phosphatase - Plasmodium yoelii
yoelii
Length = 952
Score = 33.5 bits (73), Expect = 5.7
Identities = 23/73 (31%), Positives = 33/73 (45%), Gaps = 8/73 (10%)
Frame = -3
Query: 635 NSKANLATLSELSAVTTFIDSTTPF------TDSCSN-IAYSPSVFCLIK-QHQCPYVWS 480
N+ N+ T +E + TF DST P C N +Y S +IK ++C Y+
Sbjct: 238 NTNKNIYTQNEDVIINTFTDSTNPIHSHENDVSICKNDTSYESSDSYIIKTNNECNYIGD 297
Query: 479 QRQGKIYSSECKH 441
R K S EC +
Sbjct: 298 TRYRKSCSGECNY 310
>UniRef50_Q4WN09 Cluster: ABC transporter, putative; n=12;
Pezizomycotina|Rep: ABC transporter, putative -
Aspergillus fumigatus (Sartorya fumigata)
Length = 1526
Score = 33.5 bits (73), Expect = 5.7
Identities = 21/80 (26%), Positives = 37/80 (46%)
Frame = -3
Query: 623 NLATLSELSAVTTFIDSTTPFTDSCSNIAYSPSVFCLIKQHQCPYVWSQRQGKIYSSECK 444
+L TL++++ V+T + + N+ LI++ +C Y S ++ K Y
Sbjct: 365 SLRTLTDMANVSTLV----ALYQASENLYNLFDKVMLIEEGKCAYYGSAKEAKAYFERLG 420
Query: 443 HTCPVRF*EPHCVTSHRLPH 384
CP R+ P +TS PH
Sbjct: 421 FECPPRWTTPDFLTSVSDPH 440
>UniRef50_A3BGI7 Cluster: Putative uncharacterized protein; n=1;
Oryza sativa (japonica cultivar-group)|Rep: Putative
uncharacterized protein - Oryza sativa subsp. japonica
(Rice)
Length = 377
Score = 33.1 bits (72), Expect = 7.6
Identities = 16/42 (38%), Positives = 27/42 (64%), Gaps = 1/42 (2%)
Frame = +1
Query: 538 AMLEHESVNGVV-ESMKVVTADNSERVARFAFEFAKKNGRKK 660
AML+ +V V+ + ++ N+E+V RFA E K++GR+K
Sbjct: 312 AMLQQRNVEAVMFQGRRLAGETNAEKVERFARELIKEHGRRK 353
>UniRef50_O14122 Cluster: Cullin-4; n=1; Schizosaccharomyces
pombe|Rep: Cullin-4 - Schizosaccharomyces pombe (Fission
yeast)
Length = 734
Score = 33.1 bits (72), Expect = 7.6
Identities = 19/74 (25%), Positives = 36/74 (48%)
Frame = +2
Query: 230 IRSRHIQILGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSR 409
+R R ++ + + V+ M +DD VQY I +K G+ L +++T E + +
Sbjct: 664 VRDRQFELQASIV--RVMKQKEKMKHDDLVQYVINNVKDRGIPLVSDVKTAIEK--LLEK 719
Query: 410 NVALRNELDMYAYI 451
R + D+Y Y+
Sbjct: 720 EYLEREDNDIYTYV 733
>UniRef50_UPI000065E6FA Cluster:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
epsilon 1 (EC 3.1.4.11) (Phospholipase C-epsilon-1)
(PLC-epsilon-1) (Phosphoinositide-specific phospholipase
C epsilon-1) (Pancreas- enriched phospholipase C).; n=9;
Euteleostomi|Rep: 1-phosphatidylinositol-4,5-bisphosphate
phosphodiesterase epsilon 1 (EC 3.1.4.11) (Phospholipase
C-epsilon-1) (PLC-epsilon-1) (Phosphoinositide-specific
phospholipase C epsilon-1) (Pancreas- enriched
phospholipase C). - Takifugu rubripes
Length = 1761
Score = 32.7 bits (71), Expect = 10.0
Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Frame = -2
Query: 357 PTPFLLMVVIAYWTSSSL-SIVGSMSTTSKSIGAPSI*ICRERIPCTQDR 211
P PF + V T+ L +VGS+ S S G +C E++P T++R
Sbjct: 1512 PEPFTVFSVTEQITAKQLLDMVGSVGKYSASAGGNPYFLCEEKVPLTKER 1561
>UniRef50_A3W960 Cluster: SCO1/SenC family protein; n=2;
Roseovarius|Rep: SCO1/SenC family protein - Roseovarius
sp. 217
Length = 217
Score = 32.7 bits (71), Expect = 10.0
Identities = 17/45 (37%), Positives = 25/45 (55%)
Frame = +2
Query: 257 GAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEA 391
G + ++ IDP +D + + A+T I + VGL GN E SEA
Sbjct: 101 GISVSPVLITIDPVLDTVETMGPALTKISADLVGLTGNREALSEA 145
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 807,340,273
Number of Sequences: 1657284
Number of extensions: 17466785
Number of successful extensions: 50408
Number of sequences better than 10.0: 100
Number of HSP's better than 10.0 without gapping: 48030
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 50337
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 62146450145
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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