Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= ovS335F04f
(521 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
D86425-1|BAA13087.1| 1376|Homo sapiens osteonidogen protein. 136 6e-32
BC035608-1|AAH35608.1| 969|Homo sapiens NID2 protein protein. 136 6e-32
AJ223500-1|CAA11418.1| 1375|Homo sapiens nidogen-2 protein. 136 6e-32
AB009799-1|BAA24112.1| 1376|Homo sapiens osteonidogen protein. 136 6e-32
X82245-1|CAA57709.1| 1246|Homo sapiens nidogen protein. 133 4e-31
M30269-1|AAA59932.1| 1247|Homo sapiens nidogen protein. 133 4e-31
M27445-1|AAA57261.1| 581|Homo sapiens nidogen protein. 133 4e-31
BC045606-1|AAH45606.1| 1114|Homo sapiens NID1 protein protein. 133 4e-31
AL139161-2|CAI23422.1| 1247|Homo sapiens nidogen 1 protein. 133 4e-31
AL139161-1|CAI23421.1| 1114|Homo sapiens nidogen 1 protein. 133 4e-31
AL122018-2|CAI22681.1| 1247|Homo sapiens nidogen 1 protein. 133 4e-31
AL122018-1|CAI22680.1| 1114|Homo sapiens nidogen 1 protein. 133 4e-31
AB209448-1|BAD92685.1| 1241|Homo sapiens nidogen (enactin) varia... 127 3e-29
AB084910-1|BAD83615.1| 1905|Homo sapiens low density lipoprotein... 126 6e-29
AB011540-1|BAA32468.1| 1576|Homo sapiens MEGF7 protein. 126 6e-29
AF283321-1|AAK52433.1| 1611|Homo sapiens low density lipoprotein... 124 2e-28
AF077820-1|AAC72791.1| 1615|Homo sapiens LDL receptor member LR3... 124 2e-28
AF064548-1|AAC36467.1| 1615|Homo sapiens low-density lipoprotein... 124 2e-28
AB017498-1|BAA33051.1| 1615|Homo sapiens Lipoprotein Receptor Re... 124 2e-28
AB231861-1|BAE19679.1| 1950|Homo sapiens low-density lipoprotein... 120 4e-27
BC126405-1|AAI26406.1| 1613|Homo sapiens low density lipoprotein... 116 7e-26
BC117136-1|AAI17137.1| 1613|Homo sapiens low density lipoprotein... 116 7e-26
AF074264-1|AAC33006.1| 1613|Homo sapiens LDL receptor-related pr... 116 7e-26
X13916-1|CAA32112.1| 4544|Homo sapiens LDL-receptor related prec... 112 6e-25
DQ314873-1|ABC40732.1| 4544|Homo sapiens low density lipoprotein... 112 6e-25
AF058427-1|AAC64265.1| 4544|Homo sapiens lipoprotein receptor-re... 112 6e-25
AB209683-1|BAD92920.1| 1477|Homo sapiens low density lipoprotein... 111 1e-24
AF283374-1|AAL38108.1| 1731|Homo sapiens candidate tumor suppres... 108 1e-23
AF176832-1|AAF70379.1| 4599|Homo sapiens low density lipoprotein... 108 1e-23
U33837-1|AAB41649.1| 4655|Homo sapiens gp330 precursor protein. 105 1e-22
AY265358-1|AAP88586.1| 4655|Homo sapiens glycoprotein receptor g... 105 1e-22
AY265357-1|AAP88585.1| 4655|Homo sapiens glycoprotein receptor g... 105 1e-22
AC007556-2|AAX88965.1| 3881|Homo sapiens unknown protein. 105 1e-22
X04571-1|CAA28240.1| 1207|Homo sapiens protein ( Human mRNA for ... 103 4e-22
BC113461-1|AAI13462.1| 1207|Homo sapiens epidermal growth factor... 103 4e-22
BC093731-1|AAH93731.1| 1207|Homo sapiens epidermal growth factor... 103 4e-22
AY506357-1|AAR84237.1| 1152|Homo sapiens truncated epidermal gro... 103 4e-22
AC117947-1|AAX88968.1| 346|Homo sapiens unknown protein. 101 1e-21
Z75190-1|CAA99509.1| 699|Homo sapiens apolipoprotein E receptor... 99 8e-21
D86407-2|BAA21825.1| 793|Homo sapiens ApoER2delta4-7 protein. 99 8e-21
D86407-1|BAA21824.1| 963|Homo sapiens ApoER2 protein. 99 8e-21
D50678-1|BAA09328.1| 963|Homo sapiens apolipoprotein E receptor... 99 8e-21
BC051836-1|AAH51836.2| 904|Homo sapiens low density lipoprotein... 99 8e-21
AL606760-4|CAI18908.1| 963|Homo sapiens low density lipoprotein... 99 8e-21
AL606760-3|CAI18909.1| 700|Homo sapiens low density lipoprotein... 99 8e-21
AL606760-2|CAI18910.1| 904|Homo sapiens low density lipoprotein... 99 8e-21
AL355483-3|CAI22781.1| 963|Homo sapiens low density lipoprotein... 99 8e-21
AL355483-2|CAI22782.1| 700|Homo sapiens low density lipoprotein... 99 8e-21
AL355483-1|CAI22780.1| 904|Homo sapiens low density lipoprotein... 99 8e-21
BC139736-1|AAI39737.1| 224|Homo sapiens LRP5L protein protein. 95 1e-19
AK054663-1|BAB70786.1| 820|Homo sapiens umor (LRPDIT) mRNA. pr... 94 2e-19
AC010740-1|AAY14689.1| 862|Homo sapiens unknown protein. 94 2e-19
AC008178-1|AAY24266.1| 773|Homo sapiens unknown protein. 94 2e-19
AB209498-1|BAD92735.1| 2359|Homo sapiens low density lipoprotein... 93 5e-19
S73145-1|AAB30825.1| 268|Homo sapiens calcium sensor protein pr... 89 7e-18
U04441-1|AAB02882.1| 1751|Homo sapiens glycoprotein 330 protein. 86 8e-17
AF283342-1|AAL38107.1| 881|Homo sapiens candidate tumor suppres... 85 1e-16
AC073319-1|AAX93075.1| 585|Homo sapiens unknown protein. 85 1e-16
L00352-1|AAA56833.1| 860|Homo sapiens low density lipoprotein r... 83 6e-16
BT007361-1|AAP36025.1| 860|Homo sapiens low density lipoprotein... 83 6e-16
BC014514-1|AAH14514.1| 860|Homo sapiens low density lipoprotein... 83 6e-16
AY324609-1|AAP72971.1| 860|Homo sapiens low density lipoprotein... 83 6e-16
AY114155-1|AAM56036.1| 860|Homo sapiens low density lipoprotein... 83 6e-16
AF217403-1|AAF24515.1| 837|Homo sapiens low density lipoprotein... 83 6e-16
AB209409-1|BAD92646.1| 870|Homo sapiens low density lipoprotein... 83 6e-16
S73849-1|AAB31735.1| 873|Homo sapiens very low density lipoprot... 82 1e-15
L22431-1|AAA61344.1| 873|Homo sapiens very low density lipoprot... 82 1e-15
L20470-1|AAA53684.1| 873|Homo sapiens very low density lipoprot... 82 1e-15
D16532-1|BAA03969.1| 873|Homo sapiens very low density lipoprot... 82 1e-15
D16494-1|BAA03946.1| 845|Homo sapiens very low density lipoprot... 82 1e-15
D16493-1|BAA03945.1| 873|Homo sapiens very low density lipoprot... 82 1e-15
DQ067198-1|AAY46157.1| 873|Homo sapiens very low density lipopr... 82 1e-15
BC142653-1|AAI42654.1| 845|Homo sapiens very low density lipopr... 82 1e-15
AL450467-4|CAH72453.1| 752|Homo sapiens very low density lipopr... 82 1e-15
AL450467-3|CAH72455.1| 845|Homo sapiens very low density lipopr... 82 1e-15
AL450467-2|CAH72454.1| 873|Homo sapiens very low density lipopr... 82 1e-15
AK092381-1|BAC03874.1| 752|Homo sapiens protein ( Homo sapiens ... 82 1e-15
Y08110-1|CAA69325.1| 2214|Homo sapiens mosaic protein LR11 protein. 81 2e-15
U60975-1|AAC50891.2| 2214|Homo sapiens gp250 precursor protein. 81 2e-15
AF283408-1|AAL38109.1| 1537|Homo sapiens candidate tumor suppres... 76 9e-14
AB209707-1|BAD92944.1| 1720|Homo sapiens low density lipoprotein... 76 9e-14
AC093039-1|AAX88911.1| 425|Homo sapiens unknown protein. 60 6e-09
BC021204-1|AAH21204.1| 439|Homo sapiens LRP1 protein protein. 58 2e-08
AC068195-1|AAX93243.1| 1126|Homo sapiens unknown protein. 47 5e-05
AC108036-1|AAX93208.1| 449|Homo sapiens unknown protein. 43 8e-04
AC068287-1|AAY24318.1| 223|Homo sapiens unknown protein. 35 0.15
AB210026-1|BAE06108.1| 2018|Homo sapiens MYH10 variant protein p... 30 4.3
AB067384-1|BAC02419.1| 124|Homo sapiens immunoglobulin heavy ch... 30 4.3
U34304-1|AAA84880.1| 81|Homo sapiens nonmuscle myosin heavy ch... 29 7.5
M69181-1|AAA99177.1| 1976|Homo sapiens non-muscle myosin B protein. 29 7.5
BC117691-1|AAI17692.1| 1976|Homo sapiens myosin, heavy chain 10,... 29 7.5
BC117690-1|AAI17691.1| 1976|Homo sapiens myosin, heavy chain 10,... 29 7.5
M95724-1|AAA51974.1| 943|Homo sapiens centromere autoantigen C ... 29 9.9
BC041117-1|AAH41117.1| 943|Homo sapiens centromere protein C 1 ... 29 9.9
>D86425-1|BAA13087.1| 1376|Homo sapiens osteonidogen protein.
Length = 1376
Score = 136 bits (328), Expect = 6e-32
Identities = 72/170 (42%), Positives = 99/170 (58%), Gaps = 3/170 (1%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYS--PREFATPINSGISQVAVSVSVDCFSGKIYWGDVV 184
P G FL+ + G I +P + ++ A + S + V + DC +YW DV
Sbjct: 1104 PPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVA 1163
Query: 185 SNNIKRAGYD-GSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKV 361
I RAG + G+E E +N+G+ISPEGLAID R ++WTDS IE A LD RKV
Sbjct: 1164 GRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKV 1223
Query: 362 LFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
LF ++ NPR IAV P RG ++WTDWNR PKIE +++DG R +L+ +
Sbjct: 1224 LFYT-DLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINT 1272
Score = 43.2 bits (97), Expect = 6e-04
Identities = 29/107 (27%), Positives = 47/107 (43%), Gaps = 2/107 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDV--VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
+++VD G +YW D + I+ + DG +NT I P GL D ++ + W D
Sbjct: 1234 AIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWAD 1293
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
+ +E D R+V+ N+ P I + + TDW R
Sbjct: 1294 AGTKKLECTLPDGTGRRVI--QNNLKYPFSIVSYADH--FYHTDWRR 1336
>BC035608-1|AAH35608.1| 969|Homo sapiens NID2 protein protein.
Length = 969
Score = 136 bits (328), Expect = 6e-32
Identities = 72/170 (42%), Positives = 99/170 (58%), Gaps = 3/170 (1%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYS--PREFATPINSGISQVAVSVSVDCFSGKIYWGDVV 184
P G FL+ + G I +P + ++ A + S + V + DC +YW DV
Sbjct: 697 PPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVA 756
Query: 185 SNNIKRAGYD-GSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKV 361
I RAG + G+E E +N+G+ISPEGLAID R ++WTDS IE A LD RKV
Sbjct: 757 GRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKV 816
Query: 362 LFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
LF ++ NPR IAV P RG ++WTDWNR PKIE +++DG R +L+ +
Sbjct: 817 LFYT-DLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINT 865
Score = 43.2 bits (97), Expect = 6e-04
Identities = 29/107 (27%), Positives = 47/107 (43%), Gaps = 2/107 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDV--VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
+++VD G +YW D + I+ + DG +NT I P GL D ++ + W D
Sbjct: 827 AIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWAD 886
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
+ +E D R+V+ N+ P I + + TDW R
Sbjct: 887 AGTKKLECTLPDGTGRRVI--QNNLKYPFSIVSYADH--FYHTDWRR 929
>AJ223500-1|CAA11418.1| 1375|Homo sapiens nidogen-2 protein.
Length = 1375
Score = 136 bits (328), Expect = 6e-32
Identities = 72/170 (42%), Positives = 99/170 (58%), Gaps = 3/170 (1%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYS--PREFATPINSGISQVAVSVSVDCFSGKIYWGDVV 184
P G FL+ + G I +P + ++ A + S + V + DC +YW DV
Sbjct: 1103 PPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVA 1162
Query: 185 SNNIKRAGYD-GSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKV 361
I RAG + G+E E +N+G+ISPEGLAID R ++WTDS IE A LD RKV
Sbjct: 1163 GRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKV 1222
Query: 362 LFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
LF ++ NPR IAV P RG ++WTDWNR PKIE +++DG R +L+ +
Sbjct: 1223 LFYT-DLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINT 1271
Score = 43.2 bits (97), Expect = 6e-04
Identities = 29/107 (27%), Positives = 47/107 (43%), Gaps = 2/107 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDV--VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
+++VD G +YW D + I+ + DG +NT I P GL D ++ + W D
Sbjct: 1233 AIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWAD 1292
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
+ +E D R+V+ N+ P I + + TDW R
Sbjct: 1293 AGTKKLECTLPDGTGRRVI--QNNLKYPFSIVSYADH--FYHTDWRR 1335
>AB009799-1|BAA24112.1| 1376|Homo sapiens osteonidogen protein.
Length = 1376
Score = 136 bits (328), Expect = 6e-32
Identities = 72/170 (42%), Positives = 99/170 (58%), Gaps = 3/170 (1%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYS--PREFATPINSGISQVAVSVSVDCFSGKIYWGDVV 184
P G FL+ + G I +P + ++ A + S + V + DC +YW DV
Sbjct: 1104 PPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVA 1163
Query: 185 SNNIKRAGYD-GSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKV 361
I RAG + G+E E +N+G+ISPEGLAID R ++WTDS IE A LD RKV
Sbjct: 1164 GRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKV 1223
Query: 362 LFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
LF ++ NPR IAV P RG ++WTDWNR PKIE +++DG R +L+ +
Sbjct: 1224 LFYT-DLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINT 1272
Score = 43.2 bits (97), Expect = 6e-04
Identities = 29/107 (27%), Positives = 47/107 (43%), Gaps = 2/107 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDV--VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
+++VD G +YW D + I+ + DG +NT I P GL D ++ + W D
Sbjct: 1234 AIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWAD 1293
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
+ +E D R+V+ N+ P I + + TDW R
Sbjct: 1294 AGTKKLECTLPDGTGRRVI--QNNLKYPFSIVSYADH--FYHTDWRR 1336
>X82245-1|CAA57709.1| 1246|Homo sapiens nidogen protein.
Length = 1246
Score = 133 bits (321), Expect = 4e-31
Identities = 68/167 (40%), Positives = 94/167 (56%), Gaps = 2/167 (1%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYSP--REFATPINSGISQVAVSVSVDCFSGKIYWGDVV 184
P PPG L+ + I R+P + + + A ++V + ++ DC +YW D+
Sbjct: 938 PLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDIT 997
Query: 185 SNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVL 364
+I RA G E + + SPEG+A+D RNIFWTDS IEVA LD R+VL
Sbjct: 998 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 1057
Query: 365 FSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
F ++ NPRGI RG ++WTDWNR NPKIE + MDGT R +L+
Sbjct: 1058 FET-DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 1103
>M30269-1|AAA59932.1| 1247|Homo sapiens nidogen protein.
Length = 1247
Score = 133 bits (321), Expect = 4e-31
Identities = 68/167 (40%), Positives = 94/167 (56%), Gaps = 2/167 (1%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYSP--REFATPINSGISQVAVSVSVDCFSGKIYWGDVV 184
P PPG L+ + I R+P + + + A ++V + ++ DC +YW D+
Sbjct: 939 PLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDIT 998
Query: 185 SNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVL 364
+I RA G E + + SPEG+A+D RNIFWTDS IEVA LD R+VL
Sbjct: 999 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 1058
Query: 365 FSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
F ++ NPRGI RG ++WTDWNR NPKIE + MDGT R +L+
Sbjct: 1059 FET-DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 1104
>M27445-1|AAA57261.1| 581|Homo sapiens nidogen protein.
Length = 581
Score = 133 bits (321), Expect = 4e-31
Identities = 68/167 (40%), Positives = 94/167 (56%), Gaps = 2/167 (1%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYSP--REFATPINSGISQVAVSVSVDCFSGKIYWGDVV 184
P PPG L+ + I R+P + + + A ++V + ++ DC +YW D+
Sbjct: 273 PLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDIT 332
Query: 185 SNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVL 364
+I RA G E + + SPEG+A+D RNIFWTDS IEVA LD R+VL
Sbjct: 333 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 392
Query: 365 FSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
F ++ NPRGI RG ++WTDWNR NPKIE + MDGT R +L+
Sbjct: 393 FET-DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 438
>BC045606-1|AAH45606.1| 1114|Homo sapiens NID1 protein protein.
Length = 1114
Score = 133 bits (321), Expect = 4e-31
Identities = 68/167 (40%), Positives = 94/167 (56%), Gaps = 2/167 (1%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYSP--REFATPINSGISQVAVSVSVDCFSGKIYWGDVV 184
P PPG L+ + I R+P + + + A ++V + ++ DC +YW D+
Sbjct: 806 PLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDIT 865
Query: 185 SNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVL 364
+I RA G E + + SPEG+A+D RNIFWTDS IEVA LD R+VL
Sbjct: 866 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 925
Query: 365 FSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
F ++ NPRGI RG ++WTDWNR NPKIE + MDGT R +L+
Sbjct: 926 FET-DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 971
>AL139161-2|CAI23422.1| 1247|Homo sapiens nidogen 1 protein.
Length = 1247
Score = 133 bits (321), Expect = 4e-31
Identities = 68/167 (40%), Positives = 94/167 (56%), Gaps = 2/167 (1%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYSP--REFATPINSGISQVAVSVSVDCFSGKIYWGDVV 184
P PPG L+ + I R+P + + + A ++V + ++ DC +YW D+
Sbjct: 939 PLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDIT 998
Query: 185 SNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVL 364
+I RA G E + + SPEG+A+D RNIFWTDS IEVA LD R+VL
Sbjct: 999 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 1058
Query: 365 FSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
F ++ NPRGI RG ++WTDWNR NPKIE + MDGT R +L+
Sbjct: 1059 FET-DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 1104
>AL139161-1|CAI23421.1| 1114|Homo sapiens nidogen 1 protein.
Length = 1114
Score = 133 bits (321), Expect = 4e-31
Identities = 68/167 (40%), Positives = 94/167 (56%), Gaps = 2/167 (1%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYSP--REFATPINSGISQVAVSVSVDCFSGKIYWGDVV 184
P PPG L+ + I R+P + + + A ++V + ++ DC +YW D+
Sbjct: 806 PLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDIT 865
Query: 185 SNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVL 364
+I RA G E + + SPEG+A+D RNIFWTDS IEVA LD R+VL
Sbjct: 866 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 925
Query: 365 FSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
F ++ NPRGI RG ++WTDWNR NPKIE + MDGT R +L+
Sbjct: 926 FET-DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 971
>AL122018-2|CAI22681.1| 1247|Homo sapiens nidogen 1 protein.
Length = 1247
Score = 133 bits (321), Expect = 4e-31
Identities = 68/167 (40%), Positives = 94/167 (56%), Gaps = 2/167 (1%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYSP--REFATPINSGISQVAVSVSVDCFSGKIYWGDVV 184
P PPG L+ + I R+P + + + A ++V + ++ DC +YW D+
Sbjct: 939 PLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDIT 998
Query: 185 SNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVL 364
+I RA G E + + SPEG+A+D RNIFWTDS IEVA LD R+VL
Sbjct: 999 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 1058
Query: 365 FSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
F ++ NPRGI RG ++WTDWNR NPKIE + MDGT R +L+
Sbjct: 1059 FET-DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 1104
>AL122018-1|CAI22680.1| 1114|Homo sapiens nidogen 1 protein.
Length = 1114
Score = 133 bits (321), Expect = 4e-31
Identities = 68/167 (40%), Positives = 94/167 (56%), Gaps = 2/167 (1%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYSP--REFATPINSGISQVAVSVSVDCFSGKIYWGDVV 184
P PPG L+ + I R+P + + + A ++V + ++ DC +YW D+
Sbjct: 806 PLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDIT 865
Query: 185 SNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVL 364
+I RA G E + + SPEG+A+D RNIFWTDS IEVA LD R+VL
Sbjct: 866 EPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 925
Query: 365 FSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
F ++ NPRGI RG ++WTDWNR NPKIE + MDGT R +L+
Sbjct: 926 FET-DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 971
>AB209448-1|BAD92685.1| 1241|Homo sapiens nidogen (enactin) variant
protein.
Length = 1241
Score = 127 bits (306), Expect = 3e-29
Identities = 69/167 (41%), Positives = 93/167 (55%), Gaps = 2/167 (1%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYSP--REFATPINSGISQVAVSVSVDCFSGKIYWGDVV 184
P PPG L+ + I R+P + + + A ++V + ++ DC +YW D+
Sbjct: 938 PLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDIT 997
Query: 185 SNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVL 364
+I RA G E T II EG+A+D RNIFWTDS IEVA LD R+VL
Sbjct: 998 EPSIGRASLHGGE-----PTTIIRQEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVL 1052
Query: 365 FSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
F ++ NPRGI RG ++WTDWNR NPKIE + MDGT R +L+
Sbjct: 1053 FET-DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV 1098
>AB084910-1|BAD83615.1| 1905|Homo sapiens low density lipoprotein
receptor-related protein 10 protein.
Length = 1905
Score = 126 bits (303), Expect = 6e-29
Identities = 65/166 (39%), Positives = 100/166 (60%), Gaps = 2/166 (1%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQV--AVSVSVDCFSGKIYWGDVVSNN 193
P +L+ S SI R+ S T ++ + ++ +S+ D GK+Y+ DV +
Sbjct: 1352 PETYLLFSSRGSIRRISLDTSDH---TDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDV 1408
Query: 194 IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSV 373
I+RA +GS E + G+ + +GLA+DW ARN++WTD+ + TIE + LD RKVL +
Sbjct: 1409 IRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLIN- 1467
Query: 374 QNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
++ PR IAV P++G +FWTDW KIE AN+DG+ER VL+ +
Sbjct: 1468 NSLDEPRAIAVFPRKGYLFWTDWGHI-AKIERANLDGSERKVLINT 1512
Score = 120 bits (288), Expect = 4e-27
Identities = 57/141 (40%), Positives = 87/141 (61%)
Frame = +2
Query: 89 EFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGL 268
+ PIN + ++V VD GK+YW D + I RA DGS+ E + TG+ + +GL
Sbjct: 1071 DVVVPINITMKNT-IAVGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGL 1129
Query: 269 AIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
A+D R ++WTD+ IEV NLD +RKVL QN+ +PR I ++ + G ++WTDW
Sbjct: 1130 AVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLV-WQNLDSPRAIVLYHEMGFMYWTDWG- 1187
Query: 449 SNPKIEWANMDGTERSVLLGS 511
N K+E + MDG++R+VL+ +
Sbjct: 1188 ENAKLERSGMDGSDRAVLINN 1208
Score = 118 bits (283), Expect = 2e-26
Identities = 54/113 (47%), Positives = 75/113 (66%)
Frame = +2
Query: 164 IYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLD 343
++W DV + I RA +GS E+ ++TG+ SP GLA+DW ++WTDS IEVANLD
Sbjct: 482 VFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLD 541
Query: 344 TKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVL 502
RKVL QN+ PR IA+HP G I+WTDW + P+IE ++MDG+ R ++
Sbjct: 542 GAHRKVLL-WQNLEKPRAIALHPMEGTIYWTDWG-NTPRIEASSMDGSGRRII 592
Score = 112 bits (269), Expect = 8e-25
Identities = 56/128 (43%), Positives = 77/128 (60%)
Frame = +2
Query: 128 AVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
AV++ D +YW DV ++ I RA +DG+ E ++T + SP GLAIDW ++WTD
Sbjct: 775 AVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTD 834
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ IEVAN D +R VL +N+ PR I V P G ++WTDW S PKIE A MD +
Sbjct: 835 AGTDRIEVANTDGSMRTVLI-WENLDRPRDIVVEPMGGYMYWTDWGAS-PKIERAGMDAS 892
Query: 488 ERSVLLGS 511
R V++ S
Sbjct: 893 GRQVIISS 900
Score = 77.0 bits (181), Expect = 4e-14
Identities = 44/124 (35%), Positives = 71/124 (57%), Gaps = 2/124 (1%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDV-VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
+ V+ G +YW D S I+RAG D S + +++ + P GLAID+ ++ ++W D+
Sbjct: 864 IVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAG 923
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTE 490
TIE A LD RKVL Q + +P G+ ++ +R I+WTDW + I+ A+ + G +
Sbjct: 924 MKTIEFAGLDGSKRKVLIGSQ-LPHPFGLTLYGER--IYWTDWQTKS--IQSADRLTGLD 978
Query: 491 RSVL 502
R L
Sbjct: 979 RETL 982
Score = 68.1 bits (159), Expect = 2e-11
Identities = 37/91 (40%), Positives = 55/91 (60%)
Frame = +2
Query: 170 WGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTK 349
WG + I+RA DGSE + +NT + P GL +D+ R I+W D+ IE A+L+ K
Sbjct: 1490 WGHIAK--IERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGK 1547
Query: 350 VRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
+R+VL V ++S+P A+ Q I+WTDW
Sbjct: 1548 LRQVL--VGHVSHP--FALTQQDRWIYWTDW 1574
Score = 67.7 bits (158), Expect = 2e-11
Identities = 37/126 (29%), Positives = 67/126 (53%), Gaps = 1/126 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD-SK 313
+++D + K+YW D ++ I+ A DGS + + P + ++ ++WTD
Sbjct: 821 LAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGA 880
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTER 493
IE A +D R+V+ S N++ P G+A+ +++W D IE+A +DG++R
Sbjct: 881 SPKIERAGMDASGRQVIIS-SNLTWPNGLAIDYGSQRLYWADAGMKT--IEFAGLDGSKR 937
Query: 494 SVLLGS 511
VL+GS
Sbjct: 938 KVLIGS 943
Score = 67.3 bits (157), Expect = 3e-11
Identities = 36/105 (34%), Positives = 56/105 (53%), Gaps = 1/105 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++ G IYW D + I+ + DGS +T + P GL ID++ R ++W D+
Sbjct: 558 AIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDA 617
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
K IE ANLD RK + S Q + +P I V ++WTDW+
Sbjct: 618 KHHVIERANLDGSHRKAVIS-QGLPHPFAITVF--EDSLYWTDWH 659
Score = 56.8 bits (131), Expect = 4e-08
Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 1/96 (1%)
Frame = +2
Query: 158 GKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
G +YW D N ++R+G DGS+ +N + P GL +D ++ + W D+ IE A
Sbjct: 1179 GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAA 1238
Query: 335 NLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
+L+ R L V + +P G+ + I+WTDW
Sbjct: 1239 DLNGANRHTL--VSPVQHPYGLTL--LDSYIYWTDW 1270
Score = 55.6 bits (128), Expect = 1e-07
Identities = 32/124 (25%), Positives = 62/124 (50%), Gaps = 1/124 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD-SK 313
++VD K+YW D ++ I+ A DG+ + L + P +A+ I+WTD
Sbjct: 516 LAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGN 575
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTER 493
IE +++D R+++ ++ P G+ + +++W D + IE AN+DG+ R
Sbjct: 576 TPRIEASSMDGSGRRIIADT-HLFWPNGLTIDYAGRRMYWVD--AKHHVIERANLDGSHR 632
Query: 494 SVLL 505
++
Sbjct: 633 KAVI 636
>AB011540-1|BAA32468.1| 1576|Homo sapiens MEGF7 protein.
Length = 1576
Score = 126 bits (303), Expect = 6e-29
Identities = 65/166 (39%), Positives = 100/166 (60%), Gaps = 2/166 (1%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQV--AVSVSVDCFSGKIYWGDVVSNN 193
P +L+ S SI R+ S T ++ + ++ +S+ D GK+Y+ DV +
Sbjct: 1023 PETYLLFSSRGSIRRISLDTSDH---TDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDV 1079
Query: 194 IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSV 373
I+RA +GS E + G+ + +GLA+DW ARN++WTD+ + TIE + LD RKVL +
Sbjct: 1080 IRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLIN- 1138
Query: 374 QNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
++ PR IAV P++G +FWTDW KIE AN+DG+ER VL+ +
Sbjct: 1139 NSLDEPRAIAVFPRKGYLFWTDWGHI-AKIERANLDGSERKVLINT 1183
Score = 120 bits (288), Expect = 4e-27
Identities = 57/141 (40%), Positives = 87/141 (61%)
Frame = +2
Query: 89 EFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGL 268
+ PIN + ++V VD GK+YW D + I RA DGS+ E + TG+ + +GL
Sbjct: 742 DVVVPINITMKNT-IAVGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGL 800
Query: 269 AIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
A+D R ++WTD+ IEV NLD +RKVL QN+ +PR I ++ + G ++WTDW
Sbjct: 801 AVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLV-WQNLDSPRAIVLYHEMGFMYWTDWG- 858
Query: 449 SNPKIEWANMDGTERSVLLGS 511
N K+E + MDG++R+VL+ +
Sbjct: 859 ENAKLERSGMDGSDRAVLINN 879
Score = 118 bits (283), Expect = 2e-26
Identities = 54/113 (47%), Positives = 75/113 (66%)
Frame = +2
Query: 164 IYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLD 343
++W DV + I RA +GS E+ ++TG+ SP GLA+DW ++WTDS IEVANLD
Sbjct: 153 VFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLD 212
Query: 344 TKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVL 502
RKVL QN+ PR IA+HP G I+WTDW + P+IE ++MDG+ R ++
Sbjct: 213 GAHRKVLL-WQNLEKPRAIALHPMEGTIYWTDWG-NTPRIEASSMDGSGRRII 263
Score = 112 bits (269), Expect = 8e-25
Identities = 56/128 (43%), Positives = 77/128 (60%)
Frame = +2
Query: 128 AVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
AV++ D +YW DV ++ I RA +DG+ E ++T + SP GLAIDW ++WTD
Sbjct: 446 AVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTD 505
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ IEVAN D +R VL +N+ PR I V P G ++WTDW S PKIE A MD +
Sbjct: 506 AGTDRIEVANTDGSMRTVLI-WENLDRPRDIVVEPMGGYMYWTDWGAS-PKIERAGMDAS 563
Query: 488 ERSVLLGS 511
R V++ S
Sbjct: 564 GRQVIISS 571
Score = 77.0 bits (181), Expect = 4e-14
Identities = 44/124 (35%), Positives = 71/124 (57%), Gaps = 2/124 (1%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDV-VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
+ V+ G +YW D S I+RAG D S + +++ + P GLAID+ ++ ++W D+
Sbjct: 535 IVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAG 594
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTE 490
TIE A LD RKVL Q + +P G+ ++ +R I+WTDW + I+ A+ + G +
Sbjct: 595 MKTIEFAGLDGSKRKVLIGSQ-LPHPFGLTLYGER--IYWTDWQTKS--IQSADRLTGLD 649
Query: 491 RSVL 502
R L
Sbjct: 650 RETL 653
Score = 68.1 bits (159), Expect = 2e-11
Identities = 37/91 (40%), Positives = 55/91 (60%)
Frame = +2
Query: 170 WGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTK 349
WG + I+RA DGSE + +NT + P GL +D+ R I+W D+ IE A+L+ K
Sbjct: 1161 WGHIAK--IERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGK 1218
Query: 350 VRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
+R+VL V ++S+P A+ Q I+WTDW
Sbjct: 1219 LRQVL--VGHVSHP--FALTQQDRWIYWTDW 1245
Score = 67.7 bits (158), Expect = 2e-11
Identities = 37/126 (29%), Positives = 67/126 (53%), Gaps = 1/126 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD-SK 313
+++D + K+YW D ++ I+ A DGS + + P + ++ ++WTD
Sbjct: 492 LAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGA 551
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTER 493
IE A +D R+V+ S N++ P G+A+ +++W D IE+A +DG++R
Sbjct: 552 SPKIERAGMDASGRQVIIS-SNLTWPNGLAIDYGSQRLYWADAGMKT--IEFAGLDGSKR 608
Query: 494 SVLLGS 511
VL+GS
Sbjct: 609 KVLIGS 614
Score = 67.3 bits (157), Expect = 3e-11
Identities = 36/105 (34%), Positives = 56/105 (53%), Gaps = 1/105 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++ G IYW D + I+ + DGS +T + P GL ID++ R ++W D+
Sbjct: 229 AIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDA 288
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
K IE ANLD RK + S Q + +P I V ++WTDW+
Sbjct: 289 KHHVIERANLDGSHRKAVIS-QGLPHPFAITVF--EDSLYWTDWH 330
Score = 56.8 bits (131), Expect = 4e-08
Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 1/96 (1%)
Frame = +2
Query: 158 GKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
G +YW D N ++R+G DGS+ +N + P GL +D ++ + W D+ IE A
Sbjct: 850 GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAA 909
Query: 335 NLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
+L+ R L V + +P G+ + I+WTDW
Sbjct: 910 DLNGANRHTL--VSPVQHPYGLTL--LDSYIYWTDW 941
Score = 55.6 bits (128), Expect = 1e-07
Identities = 32/124 (25%), Positives = 62/124 (50%), Gaps = 1/124 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD-SK 313
++VD K+YW D ++ I+ A DG+ + L + P +A+ I+WTD
Sbjct: 187 LAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGN 246
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTER 493
IE +++D R+++ ++ P G+ + +++W D + IE AN+DG+ R
Sbjct: 247 TPRIEASSMDGSGRRIIADT-HLFWPNGLTIDYAGRRMYWVD--AKHHVIERANLDGSHR 303
Query: 494 SVLL 505
++
Sbjct: 304 KAVI 307
>AF283321-1|AAK52433.1| 1611|Homo sapiens low density lipoprotein
receptor-related protein 5 protein.
Length = 1611
Score = 124 bits (299), Expect = 2e-28
Identities = 58/128 (45%), Positives = 82/128 (64%)
Frame = +2
Query: 128 AVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
A+++ D G +YW D I+RA DGS + +NT I P+G+A+DW ARN++WTD
Sbjct: 375 AIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTD 434
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ IEV L+ RK+L S +++ PR IA+HP G ++WTDW NPKIE AN+DG
Sbjct: 435 TGTDRIEVTRLNGTSRKILVS-EDLDEPRAIALHPVMGLMYWTDWG-ENPKIECANLDGQ 492
Query: 488 ERSVLLGS 511
ER VL+ +
Sbjct: 493 ERRVLVNA 500
Score = 114 bits (274), Expect = 2e-25
Identities = 59/162 (36%), Positives = 94/162 (58%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIK 199
P FLV + +I+R+ + + + A P+ +G+ + A ++ D + IYW DV I
Sbjct: 643 PEAFLVFTSRAAIHRISLETNNNDVAIPL-TGVKE-ASALDFDVSNNHIYWTDVSLKTIS 700
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
RA +GS E + G+ PEG+A+DW +N++W D+ IEVA LD + R+VL ++
Sbjct: 701 RAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLV-WRD 759
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ NPR +A+ P +G I+WT+W P+I A MDGT L+
Sbjct: 760 LDNPRSLALDPTKGYIYWTEWG-GKPRIVRAFMDGTNCMTLV 800
Score = 111 bits (267), Expect = 1e-24
Identities = 56/141 (39%), Positives = 85/141 (60%), Gaps = 2/141 (1%)
Frame = +2
Query: 95 ATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRA--GYDGSEFEQFLNTGIISPEGL 268
+T + SG+ A +V G +YW DV IK+ G+ + + +G++SP+GL
Sbjct: 55 STIVVSGLEDAA-AVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGL 113
Query: 269 AIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
A DW + ++WTDS+ IEVANL+ RKVLF Q++ PR IA+ P G ++WTDW
Sbjct: 114 ACDWVGKKLYWTDSETNRIEVANLNGTSRKVLF-WQDLDQPRAIALDPAHGYMYWTDWGE 172
Query: 449 SNPKIEWANMDGTERSVLLGS 511
+ P+IE A MDG+ R +++ S
Sbjct: 173 T-PRIERAGMDGSTRKIIVDS 192
Score = 69.3 bits (162), Expect = 8e-12
Identities = 56/170 (32%), Positives = 82/170 (48%), Gaps = 8/170 (4%)
Frame = +2
Query: 17 PPGNFLVTSDGTSIYR-VPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNN 193
PP FL+ S ++I R +P + P++ G+ V ++ D IYW D N
Sbjct: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLH-GLRNVK-AIDYDPLDKFIYWVDG-RQN 999
Query: 194 IKRAGYDGSEFEQFLNTGIIS-------PEGLAIDWSARNIFWTDSKKLTIEVANLDTKV 352
IKRA DG++ F+ T + P L+ID +R +FWT TI V L +
Sbjct: 1000 IKRAKDDGTQ--PFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEA 1057
Query: 353 RKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVL 502
V+ PR I V+ +RG +++T+ KIE A +DGTER VL
Sbjct: 1058 MGVVLRGDR-DKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVL 1106
Score = 58.8 bits (136), Expect = 1e-08
Identities = 33/104 (31%), Positives = 56/104 (53%), Gaps = 1/104 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++D G +YW D I+RAG DGS + +++ I P GL ID + ++W D+
Sbjct: 155 AIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADA 214
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
K I ANLD R+ + ++++P A+ ++WTDW
Sbjct: 215 KLSFIHRANLDGSFRQKVVE-GSLTHP--FALTLSGDTLYWTDW 255
Score = 56.0 bits (129), Expect = 8e-08
Identities = 39/123 (31%), Positives = 58/123 (47%), Gaps = 2/123 (1%)
Frame = +2
Query: 158 GKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
G +YW D N I+ A DG E +N + P GLA+D ++W D+K IEV
Sbjct: 471 GLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVI 530
Query: 335 NLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS- 511
N+D R+ L + + G + I+WTDW R + IE + R V++
Sbjct: 531 NVDGTKRRTLLE-DKLPHIFGFTL--LGDFIYWTDWQRRS--IERVHKVKASRDVIIDQL 585
Query: 512 PDV 520
PD+
Sbjct: 586 PDL 588
Score = 47.6 bits (108), Expect = 3e-05
Identities = 30/104 (28%), Positives = 50/104 (48%), Gaps = 2/104 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN--NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
++ V+ G +Y+ ++ I+RA DG+E E TG+I P L +D + +FW D
Sbjct: 1071 AIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVD 1130
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
+ IE +L R L NI P G+ + + ++W D
Sbjct: 1131 ADLKRIESCDLSGANRLTLEDA-NIVQPLGLTILGKH--LYWID 1171
Score = 47.2 bits (107), Expect = 3e-05
Identities = 37/130 (28%), Positives = 65/130 (50%), Gaps = 2/130 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
S+++D G IYW + I RA DG+ ++ + L ID++ + ++WTD
Sbjct: 765 SLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDK-VGRANDLTIDYADQRLYWTDL 823
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGT 487
IE +N+ + R V+ ++ +P G+ + I+WTDWN + IE A+ G
Sbjct: 824 DTNMIESSNMLGQERVVI--ADDLPHPFGLTQYSD--YIYWTDWNLHS--IERADKTSGR 877
Query: 488 ERSVLLGSPD 517
R+++ G D
Sbjct: 878 NRTLIQGHLD 887
Score = 35.5 bits (78), Expect = 0.11
Identities = 18/64 (28%), Positives = 32/64 (50%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
+++D GK+YWGD ++ I+ DG++ L + P I+WTD ++
Sbjct: 508 LALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKL--PHIFGFTLLGDFIYWTDWQR 565
Query: 317 LTIE 328
+IE
Sbjct: 566 RSIE 569
Score = 33.5 bits (73), Expect = 0.46
Identities = 18/66 (27%), Positives = 32/66 (48%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
V++ VD GK++W D I+ G+ + I+ P GL I ++++W D
Sbjct: 1115 VALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTI--LGKHLYWIDR 1172
Query: 311 KKLTIE 328
++ IE
Sbjct: 1173 QQQMIE 1178
>AF077820-1|AAC72791.1| 1615|Homo sapiens LDL receptor member LR3
protein.
Length = 1615
Score = 124 bits (299), Expect = 2e-28
Identities = 58/128 (45%), Positives = 82/128 (64%)
Frame = +2
Query: 128 AVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
A+++ D G +YW D I+RA DGS + +NT I P+G+A+DW ARN++WTD
Sbjct: 375 AIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTD 434
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ IEV L+ RK+L S +++ PR IA+HP G ++WTDW NPKIE AN+DG
Sbjct: 435 TGTDRIEVTRLNGTSRKILVS-EDLDEPRAIALHPVMGLMYWTDWG-ENPKIECANLDGQ 492
Query: 488 ERSVLLGS 511
ER VL+ +
Sbjct: 493 ERRVLVNA 500
Score = 114 bits (274), Expect = 2e-25
Identities = 59/162 (36%), Positives = 94/162 (58%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIK 199
P FLV + +I+R+ + + + A P+ +G+ + A ++ D + IYW DV I
Sbjct: 643 PEAFLVFTSRAAIHRISLETNNNDVAIPL-TGVKE-ASALDFDVSNNHIYWTDVSLKTIS 700
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
RA +GS E + G+ PEG+A+DW +N++W D+ IEVA LD + R+VL ++
Sbjct: 701 RAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLV-WRD 759
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ NPR +A+ P +G I+WT+W P+I A MDGT L+
Sbjct: 760 LDNPRSLALDPTKGYIYWTEWG-GKPRIVRAFMDGTNCMTLV 800
Score = 111 bits (267), Expect = 1e-24
Identities = 56/141 (39%), Positives = 85/141 (60%), Gaps = 2/141 (1%)
Frame = +2
Query: 95 ATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRA--GYDGSEFEQFLNTGIISPEGL 268
+T + SG+ A +V G +YW DV IK+ G+ + + +G++SP+GL
Sbjct: 55 STIVVSGLEDAA-AVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGL 113
Query: 269 AIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
A DW + ++WTDS+ IEVANL+ RKVLF Q++ PR IA+ P G ++WTDW
Sbjct: 114 ACDWVGKKLYWTDSETNRIEVANLNGTSRKVLF-WQDLDQPRAIALDPAHGYMYWTDWGE 172
Query: 449 SNPKIEWANMDGTERSVLLGS 511
+ P+IE A MDG+ R +++ S
Sbjct: 173 T-PRIERAGMDGSTRKIIVDS 192
Score = 69.3 bits (162), Expect = 8e-12
Identities = 56/170 (32%), Positives = 82/170 (48%), Gaps = 8/170 (4%)
Frame = +2
Query: 17 PPGNFLVTSDGTSIYR-VPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNN 193
PP FL+ S ++I R +P + P++ G+ V ++ D IYW D N
Sbjct: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLH-GLRNVK-AIDYDPLDKFIYWVDG-RQN 999
Query: 194 IKRAGYDGSEFEQFLNTGIIS-------PEGLAIDWSARNIFWTDSKKLTIEVANLDTKV 352
IKRA DG++ F+ T + P L+ID +R +FWT TI V L +
Sbjct: 1000 IKRAKDDGTQ--PFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEA 1057
Query: 353 RKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVL 502
V+ PR I V+ +RG +++T+ KIE A +DGTER VL
Sbjct: 1058 MGVVLRGDR-DKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVL 1106
Score = 58.8 bits (136), Expect = 1e-08
Identities = 33/104 (31%), Positives = 56/104 (53%), Gaps = 1/104 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++D G +YW D I+RAG DGS + +++ I P GL ID + ++W D+
Sbjct: 155 AIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADA 214
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
K I ANLD R+ + ++++P A+ ++WTDW
Sbjct: 215 KLSFIHRANLDGSFRQKVVE-GSLTHP--FALTLSGDTLYWTDW 255
Score = 56.0 bits (129), Expect = 8e-08
Identities = 39/123 (31%), Positives = 58/123 (47%), Gaps = 2/123 (1%)
Frame = +2
Query: 158 GKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
G +YW D N I+ A DG E +N + P GLA+D ++W D+K IEV
Sbjct: 471 GLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVI 530
Query: 335 NLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS- 511
N+D R+ L + + G + I+WTDW R + IE + R V++
Sbjct: 531 NVDGTKRRTLLE-DKLPHIFGFTL--LGDFIYWTDWQRRS--IERVHKVKASRDVIIDQL 585
Query: 512 PDV 520
PD+
Sbjct: 586 PDL 588
Score = 47.6 bits (108), Expect = 3e-05
Identities = 30/104 (28%), Positives = 50/104 (48%), Gaps = 2/104 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN--NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
++ V+ G +Y+ ++ I+RA DG+E E TG+I P L +D + +FW D
Sbjct: 1071 AIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVD 1130
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
+ IE +L R L NI P G+ + + ++W D
Sbjct: 1131 ADLKRIESCDLSGANRLTLEDA-NIVQPLGLTILGKH--LYWID 1171
Score = 47.2 bits (107), Expect = 3e-05
Identities = 37/130 (28%), Positives = 65/130 (50%), Gaps = 2/130 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
S+++D G IYW + I RA DG+ ++ + L ID++ + ++WTD
Sbjct: 765 SLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDK-VGRANDLTIDYADQRLYWTDL 823
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGT 487
IE +N+ + R V+ ++ +P G+ + I+WTDWN + IE A+ G
Sbjct: 824 DTNMIESSNMLGQERVVI--ADDLPHPFGLTQYSD--YIYWTDWNLHS--IERADKTSGR 877
Query: 488 ERSVLLGSPD 517
R+++ G D
Sbjct: 878 NRTLIQGHLD 887
Score = 35.5 bits (78), Expect = 0.11
Identities = 18/64 (28%), Positives = 32/64 (50%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
+++D GK+YWGD ++ I+ DG++ L + P I+WTD ++
Sbjct: 508 LALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKL--PHIFGFTLLGDFIYWTDWQR 565
Query: 317 LTIE 328
+IE
Sbjct: 566 RSIE 569
Score = 33.5 bits (73), Expect = 0.46
Identities = 18/66 (27%), Positives = 32/66 (48%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
V++ VD GK++W D I+ G+ + I+ P GL I ++++W D
Sbjct: 1115 VALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTI--LGKHLYWIDR 1172
Query: 311 KKLTIE 328
++ IE
Sbjct: 1173 QQQMIE 1178
>AF064548-1|AAC36467.1| 1615|Homo sapiens low-density lipoprotein
receptor-related protein 5 protein.
Length = 1615
Score = 124 bits (299), Expect = 2e-28
Identities = 58/128 (45%), Positives = 82/128 (64%)
Frame = +2
Query: 128 AVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
A+++ D G +YW D I+RA DGS + +NT I P+G+A+DW ARN++WTD
Sbjct: 375 AIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTD 434
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ IEV L+ RK+L S +++ PR IA+HP G ++WTDW NPKIE AN+DG
Sbjct: 435 TGTDRIEVTRLNGTSRKILVS-EDLDEPRAIALHPVMGLMYWTDWG-ENPKIECANLDGQ 492
Query: 488 ERSVLLGS 511
ER VL+ +
Sbjct: 493 ERRVLVNA 500
Score = 114 bits (274), Expect = 2e-25
Identities = 59/162 (36%), Positives = 94/162 (58%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIK 199
P FLV + +I+R+ + + + A P+ +G+ + A ++ D + IYW DV I
Sbjct: 643 PEAFLVFTSRAAIHRISLETNNNDVAIPL-TGVKE-ASALDFDVSNNHIYWTDVSLKTIS 700
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
RA +GS E + G+ PEG+A+DW +N++W D+ IEVA LD + R+VL ++
Sbjct: 701 RAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLV-WRD 759
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ NPR +A+ P +G I+WT+W P+I A MDGT L+
Sbjct: 760 LDNPRSLALDPTKGYIYWTEWG-GKPRIVRAFMDGTNCMTLV 800
Score = 111 bits (267), Expect = 1e-24
Identities = 56/141 (39%), Positives = 85/141 (60%), Gaps = 2/141 (1%)
Frame = +2
Query: 95 ATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRA--GYDGSEFEQFLNTGIISPEGL 268
+T + SG+ A +V G +YW DV IK+ G+ + + +G++SP+GL
Sbjct: 55 STIVVSGLEDAA-AVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGL 113
Query: 269 AIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
A DW + ++WTDS+ IEVANL+ RKVLF Q++ PR IA+ P G ++WTDW
Sbjct: 114 ACDWVGKKLYWTDSETNRIEVANLNGTSRKVLF-WQDLDQPRAIALDPAHGYMYWTDWGE 172
Query: 449 SNPKIEWANMDGTERSVLLGS 511
+ P+IE A MDG+ R +++ S
Sbjct: 173 T-PRIERAGMDGSTRKIIVDS 192
Score = 69.3 bits (162), Expect = 8e-12
Identities = 56/170 (32%), Positives = 82/170 (48%), Gaps = 8/170 (4%)
Frame = +2
Query: 17 PPGNFLVTSDGTSIYR-VPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNN 193
PP FL+ S ++I R +P + P++ G+ V ++ D IYW D N
Sbjct: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLH-GLRNVK-AIDYDPLDKFIYWVDG-RQN 999
Query: 194 IKRAGYDGSEFEQFLNTGIIS-------PEGLAIDWSARNIFWTDSKKLTIEVANLDTKV 352
IKRA DG++ F+ T + P L+ID +R +FWT TI V L +
Sbjct: 1000 IKRAKDDGTQ--PFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEA 1057
Query: 353 RKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVL 502
V+ PR I V+ +RG +++T+ KIE A +DGTER VL
Sbjct: 1058 MGVVLRGDR-DKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVL 1106
Score = 58.8 bits (136), Expect = 1e-08
Identities = 33/104 (31%), Positives = 56/104 (53%), Gaps = 1/104 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++D G +YW D I+RAG DGS + +++ I P GL ID + ++W D+
Sbjct: 155 AIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADA 214
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
K I ANLD R+ + ++++P A+ ++WTDW
Sbjct: 215 KLSFIHRANLDGSFRQKVVE-GSLTHP--FALTLSGDTLYWTDW 255
Score = 56.0 bits (129), Expect = 8e-08
Identities = 39/123 (31%), Positives = 58/123 (47%), Gaps = 2/123 (1%)
Frame = +2
Query: 158 GKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
G +YW D N I+ A DG E +N + P GLA+D ++W D+K IEV
Sbjct: 471 GLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVI 530
Query: 335 NLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS- 511
N+D R+ L + + G + I+WTDW R + IE + R V++
Sbjct: 531 NVDGTKRRTLLE-DKLPHIFGFTL--LGDFIYWTDWQRRS--IERVHKVKASRDVIIDQL 585
Query: 512 PDV 520
PD+
Sbjct: 586 PDL 588
Score = 47.6 bits (108), Expect = 3e-05
Identities = 30/104 (28%), Positives = 50/104 (48%), Gaps = 2/104 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN--NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
++ V+ G +Y+ ++ I+RA DG+E E TG+I P L +D + +FW D
Sbjct: 1071 AIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVD 1130
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
+ IE +L R L NI P G+ + + ++W D
Sbjct: 1131 ADLKRIESCDLSGANRLTLEDA-NIVQPLGLTILGKH--LYWID 1171
Score = 47.2 bits (107), Expect = 3e-05
Identities = 37/130 (28%), Positives = 65/130 (50%), Gaps = 2/130 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
S+++D G IYW + I RA DG+ ++ + L ID++ + ++WTD
Sbjct: 765 SLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDK-VGRANDLTIDYADQRLYWTDL 823
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGT 487
IE +N+ + R V+ ++ +P G+ + I+WTDWN + IE A+ G
Sbjct: 824 DTNMIESSNMLGQERVVI--ADDLPHPFGLTQYSD--YIYWTDWNLHS--IERADKTSGR 877
Query: 488 ERSVLLGSPD 517
R+++ G D
Sbjct: 878 NRTLIQGHLD 887
Score = 35.5 bits (78), Expect = 0.11
Identities = 18/64 (28%), Positives = 32/64 (50%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
+++D GK+YWGD ++ I+ DG++ L + P I+WTD ++
Sbjct: 508 LALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKL--PHIFGFTLLGDFIYWTDWQR 565
Query: 317 LTIE 328
+IE
Sbjct: 566 RSIE 569
Score = 33.5 bits (73), Expect = 0.46
Identities = 18/66 (27%), Positives = 32/66 (48%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
V++ VD GK++W D I+ G+ + I+ P GL I ++++W D
Sbjct: 1115 VALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTI--LGKHLYWIDR 1172
Query: 311 KKLTIE 328
++ IE
Sbjct: 1173 QQQMIE 1178
>AB017498-1|BAA33051.1| 1615|Homo sapiens Lipoprotein Receptor
Related Protein 5 protein.
Length = 1615
Score = 124 bits (299), Expect = 2e-28
Identities = 58/128 (45%), Positives = 82/128 (64%)
Frame = +2
Query: 128 AVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
A+++ D G +YW D I+RA DGS + +NT I P+G+A+DW ARN++WTD
Sbjct: 375 AIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTD 434
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ IEV L+ RK+L S +++ PR IA+HP G ++WTDW NPKIE AN+DG
Sbjct: 435 TGTDRIEVTRLNGTSRKILVS-EDLDEPRAIALHPVMGLMYWTDWG-ENPKIECANLDGQ 492
Query: 488 ERSVLLGS 511
ER VL+ +
Sbjct: 493 ERRVLVNA 500
Score = 114 bits (274), Expect = 2e-25
Identities = 59/162 (36%), Positives = 94/162 (58%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIK 199
P FLV + +I+R+ + + + A P+ +G+ + A ++ D + IYW DV I
Sbjct: 643 PEAFLVFTSRAAIHRISLETNNNDVAIPL-TGVKE-ASALDFDVSNNHIYWTDVSLKTIS 700
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
RA +GS E + G+ PEG+A+DW +N++W D+ IEVA LD + R+VL ++
Sbjct: 701 RAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLV-WRD 759
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ NPR +A+ P +G I+WT+W P+I A MDGT L+
Sbjct: 760 LDNPRSLALDPTKGYIYWTEWG-GKPRIVRAFMDGTNCMTLV 800
Score = 111 bits (267), Expect = 1e-24
Identities = 56/141 (39%), Positives = 85/141 (60%), Gaps = 2/141 (1%)
Frame = +2
Query: 95 ATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRA--GYDGSEFEQFLNTGIISPEGL 268
+T + SG+ A +V G +YW DV IK+ G+ + + +G++SP+GL
Sbjct: 55 STIVVSGLEDAA-AVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGL 113
Query: 269 AIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
A DW + ++WTDS+ IEVANL+ RKVLF Q++ PR IA+ P G ++WTDW
Sbjct: 114 ACDWVGKKLYWTDSETNRIEVANLNGTSRKVLF-WQDLDQPRAIALDPAHGYMYWTDWGE 172
Query: 449 SNPKIEWANMDGTERSVLLGS 511
+ P+IE A MDG+ R +++ S
Sbjct: 173 T-PRIERAGMDGSTRKIIVDS 192
Score = 69.3 bits (162), Expect = 8e-12
Identities = 56/170 (32%), Positives = 82/170 (48%), Gaps = 8/170 (4%)
Frame = +2
Query: 17 PPGNFLVTSDGTSIYR-VPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNN 193
PP FL+ S ++I R +P + P++ G+ V ++ D IYW D N
Sbjct: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLH-GLRNVK-AIDYDPLDKFIYWVDG-RQN 999
Query: 194 IKRAGYDGSEFEQFLNTGIIS-------PEGLAIDWSARNIFWTDSKKLTIEVANLDTKV 352
IKRA DG++ F+ T + P L+ID +R +FWT TI V L +
Sbjct: 1000 IKRAKDDGTQ--PFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEA 1057
Query: 353 RKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVL 502
V+ PR I V+ +RG +++T+ KIE A +DGTER VL
Sbjct: 1058 MGVVLRGDR-DKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVL 1106
Score = 58.8 bits (136), Expect = 1e-08
Identities = 33/104 (31%), Positives = 56/104 (53%), Gaps = 1/104 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++D G +YW D I+RAG DGS + +++ I P GL ID + ++W D+
Sbjct: 155 AIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADA 214
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
K I ANLD R+ + ++++P A+ ++WTDW
Sbjct: 215 KLSFIHRANLDGSFRQKVVE-GSLTHP--FALTLSGDTLYWTDW 255
Score = 56.0 bits (129), Expect = 8e-08
Identities = 39/123 (31%), Positives = 58/123 (47%), Gaps = 2/123 (1%)
Frame = +2
Query: 158 GKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
G +YW D N I+ A DG E +N + P GLA+D ++W D+K IEV
Sbjct: 471 GLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVI 530
Query: 335 NLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS- 511
N+D R+ L + + G + I+WTDW R + IE + R V++
Sbjct: 531 NVDGTKRRTLLE-DKLPHIFGFTL--LGDFIYWTDWQRRS--IERVHKVKASRDVIIDQL 585
Query: 512 PDV 520
PD+
Sbjct: 586 PDL 588
Score = 47.6 bits (108), Expect = 3e-05
Identities = 30/104 (28%), Positives = 50/104 (48%), Gaps = 2/104 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN--NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
++ V+ G +Y+ ++ I+RA DG+E E TG+I P L +D + +FW D
Sbjct: 1071 AIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVD 1130
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
+ IE +L R L NI P G+ + + ++W D
Sbjct: 1131 ADLKRIESCDLSGANRLTLEDA-NIVQPLGLTILGKH--LYWID 1171
Score = 47.2 bits (107), Expect = 3e-05
Identities = 37/130 (28%), Positives = 65/130 (50%), Gaps = 2/130 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
S+++D G IYW + I RA DG+ ++ + L ID++ + ++WTD
Sbjct: 765 SLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDK-VGRANDLTIDYADQRLYWTDL 823
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGT 487
IE +N+ + R V+ ++ +P G+ + I+WTDWN + IE A+ G
Sbjct: 824 DTNMIESSNMLGQERVVI--ADDLPHPFGLTQYSD--YIYWTDWNLHS--IERADKTSGR 877
Query: 488 ERSVLLGSPD 517
R+++ G D
Sbjct: 878 NRTLIQGHLD 887
Score = 35.5 bits (78), Expect = 0.11
Identities = 18/64 (28%), Positives = 32/64 (50%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
+++D GK+YWGD ++ I+ DG++ L + P I+WTD ++
Sbjct: 508 LALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKL--PHIFGFTLLGDFIYWTDWQR 565
Query: 317 LTIE 328
+IE
Sbjct: 566 RSIE 569
Score = 33.5 bits (73), Expect = 0.46
Identities = 18/66 (27%), Positives = 32/66 (48%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
V++ VD GK++W D I+ G+ + I+ P GL I ++++W D
Sbjct: 1115 VALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTI--LGKHLYWIDR 1172
Query: 311 KKLTIE 328
++ IE
Sbjct: 1173 QQQMIE 1178
>AB231861-1|BAE19679.1| 1950|Homo sapiens low-density lipoprotein
receptor-related protein 4 protein.
Length = 1950
Score = 120 bits (288), Expect = 4e-27
Identities = 57/141 (40%), Positives = 87/141 (61%)
Frame = +2
Query: 89 EFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGL 268
+ PIN + ++V VD GK+YW D + I RA DGS+ E + TG+ + +GL
Sbjct: 1119 DVVVPINITMKNT-IAVGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGL 1177
Query: 269 AIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
A+D R ++WTD+ IEV NLD +RKVL QN+ +PR I ++ + G ++WTDW
Sbjct: 1178 AVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLV-WQNLDSPRAIVLYHEMGFMYWTDWG- 1235
Query: 449 SNPKIEWANMDGTERSVLLGS 511
N K+E + MDG++R+VL+ +
Sbjct: 1236 ENAKLERSGMDGSDRAVLINN 1256
Score = 118 bits (283), Expect = 2e-26
Identities = 54/113 (47%), Positives = 75/113 (66%)
Frame = +2
Query: 164 IYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLD 343
++W DV + I RA +GS E+ ++TG+ SP GLA+DW ++WTDS IEVANLD
Sbjct: 530 VFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLD 589
Query: 344 TKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVL 502
RKVL QN+ PR IA+HP G I+WTDW + P+IE ++MDG+ R ++
Sbjct: 590 GAHRKVLL-WQNLEKPRAIALHPMEGTIYWTDWG-NTPRIEASSMDGSGRRII 640
Score = 114 bits (274), Expect = 2e-25
Identities = 62/166 (37%), Positives = 97/166 (58%), Gaps = 2/166 (1%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQV--AVSVSVDCFSGKIYWGDVVSNN 193
P +L+ S SI R+ S T ++ + ++ +S+ D GK+Y+ DV +
Sbjct: 1400 PETYLLFSSRGSIRRISLDTSDH---TDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDV 1456
Query: 194 IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSV 373
I+RA +GS E + G+ + +GLA+DW ARN++WTD+ + TIE + LD RKVL +
Sbjct: 1457 IRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLIN- 1515
Query: 374 QNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
++ IA P++G +FWTDW KIE AN+DG+ER VL+ +
Sbjct: 1516 ---NSLDDIAAFPRKGYLFWTDWGHI-AKIERANLDGSERKVLINT 1557
Score = 112 bits (269), Expect = 8e-25
Identities = 56/128 (43%), Positives = 77/128 (60%)
Frame = +2
Query: 128 AVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
AV++ D +YW DV ++ I RA +DG+ E ++T + SP GLAIDW ++WTD
Sbjct: 823 AVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTD 882
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ IEVAN D +R VL +N+ PR I V P G ++WTDW S PKIE A MD +
Sbjct: 883 AGTDRIEVANTDGSMRTVLI-WENLDRPRDIVVEPMGGYMYWTDWGAS-PKIERAGMDAS 940
Query: 488 ERSVLLGS 511
R V++ S
Sbjct: 941 GRQVIISS 948
Score = 77.0 bits (181), Expect = 4e-14
Identities = 44/124 (35%), Positives = 71/124 (57%), Gaps = 2/124 (1%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDV-VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
+ V+ G +YW D S I+RAG D S + +++ + P GLAID+ ++ ++W D+
Sbjct: 912 IVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAG 971
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTE 490
TIE A LD RKVL Q + +P G+ ++ +R I+WTDW + I+ A+ + G +
Sbjct: 972 MKTIEFAGLDGSKRKVLIGSQ-LPHPFGLTLYGER--IYWTDWQTKS--IQSADRLTGLD 1026
Query: 491 RSVL 502
R L
Sbjct: 1027 RETL 1030
Score = 68.1 bits (159), Expect = 2e-11
Identities = 37/91 (40%), Positives = 55/91 (60%)
Frame = +2
Query: 170 WGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTK 349
WG + I+RA DGSE + +NT + P GL +D+ R I+W D+ IE A+L+ K
Sbjct: 1535 WGHIAK--IERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGK 1592
Query: 350 VRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
+R+VL V ++S+P A+ Q I+WTDW
Sbjct: 1593 LRQVL--VGHVSHP--FALTQQDRWIYWTDW 1619
Score = 67.7 bits (158), Expect = 2e-11
Identities = 37/126 (29%), Positives = 67/126 (53%), Gaps = 1/126 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD-SK 313
+++D + K+YW D ++ I+ A DGS + + P + ++ ++WTD
Sbjct: 869 LAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGA 928
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTER 493
IE A +D R+V+ S N++ P G+A+ +++W D IE+A +DG++R
Sbjct: 929 SPKIERAGMDASGRQVIIS-SNLTWPNGLAIDYGSQRLYWADAGMKT--IEFAGLDGSKR 985
Query: 494 SVLLGS 511
VL+GS
Sbjct: 986 KVLIGS 991
Score = 67.3 bits (157), Expect = 3e-11
Identities = 36/105 (34%), Positives = 56/105 (53%), Gaps = 1/105 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++ G IYW D + I+ + DGS +T + P GL ID++ R ++W D+
Sbjct: 606 AIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDA 665
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
K IE ANLD RK + S Q + +P I V ++WTDW+
Sbjct: 666 KHHVIERANLDGSHRKAVIS-QGLPHPFAITVF--EDSLYWTDWH 707
Score = 56.8 bits (131), Expect = 4e-08
Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 1/96 (1%)
Frame = +2
Query: 158 GKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
G +YW D N ++R+G DGS+ +N + P GL +D ++ + W D+ IE A
Sbjct: 1227 GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAA 1286
Query: 335 NLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
+L+ R L V + +P G+ + I+WTDW
Sbjct: 1287 DLNGANRHTL--VSPVQHPYGLTL--LDSYIYWTDW 1318
Score = 55.6 bits (128), Expect = 1e-07
Identities = 32/124 (25%), Positives = 62/124 (50%), Gaps = 1/124 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD-SK 313
++VD K+YW D ++ I+ A DG+ + L + P +A+ I+WTD
Sbjct: 564 LAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGN 623
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTER 493
IE +++D R+++ ++ P G+ + +++W D + IE AN+DG+ R
Sbjct: 624 TPRIEASSMDGSGRRIIADT-HLFWPNGLTIDYAGRRMYWVD--AKHHVIERANLDGSHR 680
Query: 494 SVLL 505
++
Sbjct: 681 KAVI 684
>BC126405-1|AAI26406.1| 1613|Homo sapiens low density lipoprotein
receptor-related protein 6 protein.
Length = 1613
Score = 116 bits (278), Expect = 7e-26
Identities = 61/143 (42%), Positives = 86/143 (60%), Gaps = 1/143 (0%)
Frame = +2
Query: 86 REFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQ-FLNTGIISPE 262
+E AT + G+ A +V G IYW DV IKR ++ +E Q + +G++SP+
Sbjct: 40 KENATIVVGGLEDAA-AVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPD 98
Query: 263 GLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
GLA DW ++WTDS+ IEV+NLD +RKVLF Q + PR IA+ P G ++WTDW
Sbjct: 99 GLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLF-WQELDQPRAIALDPSSGFMYWTDW 157
Query: 443 NRSNPKIEWANMDGTERSVLLGS 511
PKIE A MDG+ R +++ S
Sbjct: 158 GEV-PKIERAGMDGSSRFIIINS 179
Score = 111 bits (268), Expect = 1e-24
Identities = 57/162 (35%), Positives = 94/162 (58%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIK 199
P FL+ S I R+ + + A P+ +G+ + A ++ D +IYW D+ I
Sbjct: 630 PEAFLLFSRRADIRRISLETNNNNVAIPL-TGVKE-ASALDFDVTDNRIYWTDISLKTIS 687
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
RA +GS E + G+ PEG+A+DW +N++W D+ IEV+ LD + R+VL ++
Sbjct: 688 RAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLV-WKD 746
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ +PR +A+ P G ++WT+W PKI+ A MDG+ER+ L+
Sbjct: 747 LDSPRALALDPAEGFMYWTEWG-GKPKIDRAAMDGSERTTLV 787
Score = 106 bits (255), Expect = 4e-23
Identities = 51/128 (39%), Positives = 78/128 (60%)
Frame = +2
Query: 128 AVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
A+++ D G IYW D I+R+ DGS + + I P+G+A+DW ARN++WTD
Sbjct: 362 AIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTD 421
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ IEV L+ +RK+L S +++ PR I + P G ++WTDW PKIE A +DG+
Sbjct: 422 TGTDRIEVTRLNGTMRKILIS-EDLEEPRAIVLDPMVGYMYWTDWGEI-PKIERAALDGS 479
Query: 488 ERSVLLGS 511
+R VL+ +
Sbjct: 480 DRVVLVNT 487
Score = 75.4 bits (177), Expect = 1e-13
Identities = 55/172 (31%), Positives = 89/172 (51%), Gaps = 8/172 (4%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPF--KYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNN 193
P FL+ S ++I R+ + SP + PI+S + V ++ D ++YW D N
Sbjct: 932 PTTFLLFSQKSAINRMVIDEQQSP-DIILPIHS-LRNVR-AIDYDPLDKQLYWIDSRQNM 988
Query: 194 IKRAGYDGSEFEQFLNTGI------ISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVR 355
I++A DGS+ + + + I P L+ID +R I+WT I V LD +
Sbjct: 989 IRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 1048
Query: 356 KVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
V+ + PR + V+P++G +++T+ +PKIE A +DGTER VL S
Sbjct: 1049 GVVLKGEQ-DRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFS 1099
Score = 65.7 bits (153), Expect = 9e-11
Identities = 44/131 (33%), Positives = 66/131 (50%), Gaps = 2/131 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVS-NNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ +D G +YW D I+RA DGS+ +NT + P GLA+D+ I+W D+
Sbjct: 450 AIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDA 509
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTE 490
K IEV N D R+VL I + G + ++WTDW R + IE + E
Sbjct: 510 KTDKIEVMNTDGTGRRVLVE-DKIPHIFGFTL--LGDYVYWTDWQRRS--IERVHKRSAE 564
Query: 491 RSVLLGS-PDV 520
R V++ PD+
Sbjct: 565 REVIIDQLPDL 575
Score = 60.5 bits (140), Expect = 3e-09
Identities = 35/105 (33%), Positives = 56/105 (53%), Gaps = 1/105 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVS-NNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++D SG +YW D I+RAG DGS +N+ I P GL +D+ + ++W D+
Sbjct: 142 AIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADA 201
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
K I +NLD R+ +V S P A+ ++WTDW+
Sbjct: 202 KLNFIHKSNLDGTNRQ---AVVKGSLPHPFALTLFEDILYWTDWS 243
Score = 58.0 bits (134), Expect = 2e-08
Identities = 41/130 (31%), Positives = 68/130 (52%), Gaps = 2/130 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++D G +YW + I RA DGSE L + GL ID++ R ++WTD
Sbjct: 752 ALALDPAEGFMYWTEWGGKPKIDRAAMDGSE-RTTLVPNVGRANGLTIDYAKRRLYWTDL 810
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGT 487
IE +N+ R+V+ ++ +P G+ + + I+WTDW+R + IE AN G
Sbjct: 811 DTNLIESSNMLGLNREVI--ADDLPHPFGLTQY--QDYIYWTDWSRRS--IERANKTSGQ 864
Query: 488 ERSVLLGSPD 517
R+++ G D
Sbjct: 865 NRTIIQGHLD 874
Score = 49.2 bits (112), Expect = 9e-06
Identities = 32/102 (31%), Positives = 49/102 (48%)
Frame = +2
Query: 185 SNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVL 364
S I+RA DG+E E +G+ P LA+D +FW DS IE ++L + +++
Sbjct: 1080 SPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDL-SGANRIV 1138
Query: 365 FSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTE 490
NI P G+ V ++W D + IE +M G E
Sbjct: 1139 LEDSNILQPVGLTVF--ENWLYWID--KQQQMIEKIDMTGRE 1176
Score = 33.9 bits (74), Expect = 0.35
Identities = 19/75 (25%), Positives = 40/75 (53%), Gaps = 2/75 (2%)
Frame = +2
Query: 110 SGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAI--DWS 283
SG+S+ +++++D GK++W D I+ + G+ ++ I+ P GL + +W
Sbjct: 1099 SGLSK-PIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENW- 1156
Query: 284 ARNIFWTDSKKLTIE 328
++W D ++ IE
Sbjct: 1157 ---LYWIDKQQQMIE 1168
>BC117136-1|AAI17137.1| 1613|Homo sapiens low density lipoprotein
receptor-related protein 6 protein.
Length = 1613
Score = 116 bits (278), Expect = 7e-26
Identities = 61/143 (42%), Positives = 86/143 (60%), Gaps = 1/143 (0%)
Frame = +2
Query: 86 REFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQ-FLNTGIISPE 262
+E AT + G+ A +V G IYW DV IKR ++ +E Q + +G++SP+
Sbjct: 40 KENATIVVGGLEDAA-AVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPD 98
Query: 263 GLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
GLA DW ++WTDS+ IEV+NLD +RKVLF Q + PR IA+ P G ++WTDW
Sbjct: 99 GLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLF-WQELDQPRAIALDPSSGFMYWTDW 157
Query: 443 NRSNPKIEWANMDGTERSVLLGS 511
PKIE A MDG+ R +++ S
Sbjct: 158 GEV-PKIERAGMDGSSRFIIINS 179
Score = 111 bits (268), Expect = 1e-24
Identities = 57/162 (35%), Positives = 94/162 (58%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIK 199
P FL+ S I R+ + + A P+ +G+ + A ++ D +IYW D+ I
Sbjct: 630 PEAFLLFSRRADIRRISLETNNNNVAIPL-TGVKE-ASALDFDVTDNRIYWTDISLKTIS 687
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
RA +GS E + G+ PEG+A+DW +N++W D+ IEV+ LD + R+VL ++
Sbjct: 688 RAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLV-WKD 746
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ +PR +A+ P G ++WT+W PKI+ A MDG+ER+ L+
Sbjct: 747 LDSPRALALDPAEGFMYWTEWG-GKPKIDRAAMDGSERTTLV 787
Score = 106 bits (255), Expect = 4e-23
Identities = 51/128 (39%), Positives = 78/128 (60%)
Frame = +2
Query: 128 AVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
A+++ D G IYW D I+R+ DGS + + I P+G+A+DW ARN++WTD
Sbjct: 362 AIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTD 421
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ IEV L+ +RK+L S +++ PR I + P G ++WTDW PKIE A +DG+
Sbjct: 422 TGTDRIEVTRLNGTMRKILIS-EDLEEPRAIVLDPMVGYMYWTDWGEI-PKIERAALDGS 479
Query: 488 ERSVLLGS 511
+R VL+ +
Sbjct: 480 DRVVLVNT 487
Score = 75.4 bits (177), Expect = 1e-13
Identities = 55/172 (31%), Positives = 89/172 (51%), Gaps = 8/172 (4%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPF--KYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNN 193
P FL+ S ++I R+ + SP + PI+S + V ++ D ++YW D N
Sbjct: 932 PTTFLLFSQKSAINRMVIDEQQSP-DIILPIHS-LRNVR-AIDYDPLDKQLYWIDSRQNM 988
Query: 194 IKRAGYDGSEFEQFLNTGI------ISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVR 355
I++A DGS+ + + + I P L+ID +R I+WT I V LD +
Sbjct: 989 IRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 1048
Query: 356 KVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
V+ + PR + V+P++G +++T+ +PKIE A +DGTER VL S
Sbjct: 1049 GVVLKGEQ-DRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFS 1099
Score = 65.7 bits (153), Expect = 9e-11
Identities = 44/131 (33%), Positives = 66/131 (50%), Gaps = 2/131 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVS-NNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ +D G +YW D I+RA DGS+ +NT + P GLA+D+ I+W D+
Sbjct: 450 AIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDA 509
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTE 490
K IEV N D R+VL I + G + ++WTDW R + IE + E
Sbjct: 510 KTDKIEVMNTDGTGRRVLVE-DKIPHIFGFTL--LGDYVYWTDWQRRS--IERVHKRSAE 564
Query: 491 RSVLLGS-PDV 520
R V++ PD+
Sbjct: 565 REVIIDQLPDL 575
Score = 60.5 bits (140), Expect = 3e-09
Identities = 35/105 (33%), Positives = 56/105 (53%), Gaps = 1/105 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVS-NNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++D SG +YW D I+RAG DGS +N+ I P GL +D+ + ++W D+
Sbjct: 142 AIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADA 201
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
K I +NLD R+ +V S P A+ ++WTDW+
Sbjct: 202 KLNFIHKSNLDGTNRQ---AVVKGSLPHPFALTLFEDILYWTDWS 243
Score = 58.0 bits (134), Expect = 2e-08
Identities = 41/130 (31%), Positives = 68/130 (52%), Gaps = 2/130 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++D G +YW + I RA DGSE L + GL ID++ R ++WTD
Sbjct: 752 ALALDPAEGFMYWTEWGGKPKIDRAAMDGSE-RTTLVPNVGRANGLTIDYAKRRLYWTDL 810
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGT 487
IE +N+ R+V+ ++ +P G+ + + I+WTDW+R + IE AN G
Sbjct: 811 DTNLIESSNMLGLNREVI--ADDLPHPFGLTQY--QDYIYWTDWSRRS--IERANKTSGQ 864
Query: 488 ERSVLLGSPD 517
R+++ G D
Sbjct: 865 NRTIIQGHLD 874
Score = 49.2 bits (112), Expect = 9e-06
Identities = 32/102 (31%), Positives = 49/102 (48%)
Frame = +2
Query: 185 SNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVL 364
S I+RA DG+E E +G+ P LA+D +FW DS IE ++L + +++
Sbjct: 1080 SPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDL-SGANRIV 1138
Query: 365 FSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTE 490
NI P G+ V ++W D + IE +M G E
Sbjct: 1139 LEDSNILQPVGLTVF--ENWLYWID--KQQQMIEKIDMTGRE 1176
Score = 33.9 bits (74), Expect = 0.35
Identities = 19/75 (25%), Positives = 40/75 (53%), Gaps = 2/75 (2%)
Frame = +2
Query: 110 SGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAI--DWS 283
SG+S+ +++++D GK++W D I+ + G+ ++ I+ P GL + +W
Sbjct: 1099 SGLSK-PIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENW- 1156
Query: 284 ARNIFWTDSKKLTIE 328
++W D ++ IE
Sbjct: 1157 ---LYWIDKQQQMIE 1168
>AF074264-1|AAC33006.1| 1613|Homo sapiens LDL receptor-related
protein 6 protein.
Length = 1613
Score = 116 bits (278), Expect = 7e-26
Identities = 61/143 (42%), Positives = 86/143 (60%), Gaps = 1/143 (0%)
Frame = +2
Query: 86 REFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQ-FLNTGIISPE 262
+E AT + G+ A +V G IYW DV IKR ++ +E Q + +G++SP+
Sbjct: 40 KENATIVVGGLEDAA-AVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPD 98
Query: 263 GLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
GLA DW ++WTDS+ IEV+NLD +RKVLF Q + PR IA+ P G ++WTDW
Sbjct: 99 GLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLF-WQELDQPRAIALDPSSGFMYWTDW 157
Query: 443 NRSNPKIEWANMDGTERSVLLGS 511
PKIE A MDG+ R +++ S
Sbjct: 158 GEV-PKIERAGMDGSSRFIIINS 179
Score = 111 bits (268), Expect = 1e-24
Identities = 57/162 (35%), Positives = 94/162 (58%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIK 199
P FL+ S I R+ + + A P+ +G+ + A ++ D +IYW D+ I
Sbjct: 630 PEAFLLFSRRADIRRISLETNNNNVAIPL-TGVKE-ASALDFDVTDNRIYWTDISLKTIS 687
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
RA +GS E + G+ PEG+A+DW +N++W D+ IEV+ LD + R+VL ++
Sbjct: 688 RAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLV-WKD 746
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ +PR +A+ P G ++WT+W PKI+ A MDG+ER+ L+
Sbjct: 747 LDSPRALALDPAEGFMYWTEWG-GKPKIDRAAMDGSERTTLV 787
Score = 106 bits (255), Expect = 4e-23
Identities = 51/128 (39%), Positives = 78/128 (60%)
Frame = +2
Query: 128 AVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
A+++ D G IYW D I+R+ DGS + + I P+G+A+DW ARN++WTD
Sbjct: 362 AIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTD 421
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ IEV L+ +RK+L S +++ PR I + P G ++WTDW PKIE A +DG+
Sbjct: 422 TGTDRIEVTRLNGTMRKILIS-EDLEEPRAIVLDPMVGYMYWTDWGEI-PKIERAALDGS 479
Query: 488 ERSVLLGS 511
+R VL+ +
Sbjct: 480 DRVVLVNT 487
Score = 75.8 bits (178), Expect = 9e-14
Identities = 56/172 (32%), Positives = 89/172 (51%), Gaps = 8/172 (4%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPF--KYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNN 193
P FL+ S ++I R+ + SP + PI+S + V ++ D ++YW D N
Sbjct: 932 PTTFLLFSQKSAINRMVIDEQQSP-DIILPIHS-LRNVR-AIDYDPLDKQLYWIDSRQNM 988
Query: 194 IKRAGYDGSEFEQFLNTGI------ISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVR 355
I++A DGS+ + + + I P L+ID +R I+WT I V LD +
Sbjct: 989 IRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 1048
Query: 356 KVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
V+ + PR I V+P++G +++T+ +PKIE A +DGTER VL S
Sbjct: 1049 GVVLKGEQ-DRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFS 1099
Score = 65.7 bits (153), Expect = 9e-11
Identities = 44/131 (33%), Positives = 66/131 (50%), Gaps = 2/131 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVS-NNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ +D G +YW D I+RA DGS+ +NT + P GLA+D+ I+W D+
Sbjct: 450 AIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDA 509
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTE 490
K IEV N D R+VL I + G + ++WTDW R + IE + E
Sbjct: 510 KTDKIEVMNTDGTGRRVLVE-DKIPHIFGFTL--LGDYVYWTDWQRRS--IERVHKRSAE 564
Query: 491 RSVLLGS-PDV 520
R V++ PD+
Sbjct: 565 REVIIDQLPDL 575
Score = 60.5 bits (140), Expect = 3e-09
Identities = 35/105 (33%), Positives = 56/105 (53%), Gaps = 1/105 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVS-NNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++D SG +YW D I+RAG DGS +N+ I P GL +D+ + ++W D+
Sbjct: 142 AIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADA 201
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
K I +NLD R+ +V S P A+ ++WTDW+
Sbjct: 202 KLNFIHKSNLDGTNRQ---AVVKGSLPHPFALTLFEDILYWTDWS 243
Score = 58.0 bits (134), Expect = 2e-08
Identities = 41/130 (31%), Positives = 68/130 (52%), Gaps = 2/130 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++D G +YW + I RA DGSE L + GL ID++ R ++WTD
Sbjct: 752 ALALDPAEGFMYWTEWGGKPKIDRAAMDGSE-RTTLVPNVGRANGLTIDYAKRRLYWTDL 810
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGT 487
IE +N+ R+V+ ++ +P G+ + + I+WTDW+R + IE AN G
Sbjct: 811 DTNLIESSNMLGLNREVI--ADDLPHPFGLTQY--QDYIYWTDWSRRS--IERANKTSGQ 864
Query: 488 ERSVLLGSPD 517
R+++ G D
Sbjct: 865 NRTIIQGHLD 874
Score = 49.2 bits (112), Expect = 9e-06
Identities = 32/102 (31%), Positives = 49/102 (48%)
Frame = +2
Query: 185 SNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVL 364
S I+RA DG+E E +G+ P LA+D +FW DS IE ++L + +++
Sbjct: 1080 SPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDL-SGANRIV 1138
Query: 365 FSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTE 490
NI P G+ V ++W D + IE +M G E
Sbjct: 1139 LEDSNILQPVGLTVF--ENWLYWID--KQQQMIEKIDMTGRE 1176
Score = 33.9 bits (74), Expect = 0.35
Identities = 19/75 (25%), Positives = 40/75 (53%), Gaps = 2/75 (2%)
Frame = +2
Query: 110 SGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAI--DWS 283
SG+S+ +++++D GK++W D I+ + G+ ++ I+ P GL + +W
Sbjct: 1099 SGLSK-PIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENW- 1156
Query: 284 ARNIFWTDSKKLTIE 328
++W D ++ IE
Sbjct: 1157 ---LYWIDKQQQMIE 1168
>X13916-1|CAA32112.1| 4544|Homo sapiens LDL-receptor related precursor
(AA -19 to 4525) protein.
Length = 4544
Score = 112 bits (270), Expect = 6e-25
Identities = 64/161 (39%), Positives = 91/161 (56%)
Frame = +2
Query: 23 GNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKR 202
G+FL+ S I +P + + A SG S +AV + + IYW D+ + I R
Sbjct: 1890 GSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTS-LAVGIDFHAENDTIYWVDMGLSTISR 1948
Query: 203 AGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNI 382
A D + E + GI EG+A+DW A NI+WTD IEVA L+ R V+ S Q +
Sbjct: 1949 AKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVIS-QGL 2007
Query: 383 SNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
PR I VHP++G +FWT+W + P+IE + +DGTER VL+
Sbjct: 2008 DKPRAITVHPEKGYLFWTEWGQ-YPRIERSRLDGTERVVLV 2047
Score = 99.1 bits (236), Expect = 8e-21
Identities = 51/114 (44%), Positives = 71/114 (62%), Gaps = 4/114 (3%)
Frame = +2
Query: 164 IYWGDVVSNNIKRAGY--DGS--EFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEV 331
+YW DVV + I R +G+ FE + G+ +PEGLA+DW A NI+W +S IEV
Sbjct: 1311 LYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEV 1370
Query: 332 ANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTER 493
A LD +R L + +I +PR IA+ P+ G +FWTDW+ S P+IE A+M G R
Sbjct: 1371 AKLDGTLRTTLLA-GDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGR 1423
Score = 99.1 bits (236), Expect = 8e-21
Identities = 52/131 (39%), Positives = 75/131 (57%), Gaps = 2/131 (1%)
Frame = +2
Query: 116 ISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
I V V + D ++YW DV + IKRA +G+ E ++ + + GLA+DW +RN+
Sbjct: 1614 IDNVTV-LDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNL 1672
Query: 296 FWT--DSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEW 469
FWT D+ K I VA LD + + VQ + P G+ VHP RGK++WTD I
Sbjct: 1673 FWTSYDTNKKQINVARLDGSFKNAV--VQGLEQPHGLVVHPLRGKLYWTD----GDNISM 1726
Query: 470 ANMDGTERSVL 502
ANMDG+ R++L
Sbjct: 1727 ANMDGSNRTLL 1737
Score = 93.1 bits (221), Expect = 5e-19
Identities = 50/138 (36%), Positives = 76/138 (55%), Gaps = 2/138 (1%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSNN--IKRAGYDGSEFEQFLNTGIISPEGLA 271
T + G++ AV++ D IYW DV + I+R +GS + TG+ +P+GLA
Sbjct: 3050 TLLKQGLNN-AVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLA 3108
Query: 272 IDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRS 451
+DW N++W D + TIEV+ L+ R VL S + PR + V Q G ++WTDW
Sbjct: 3109 VDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVS-SGLREPRALVVDVQNGYLYWTDWG-D 3166
Query: 452 NPKIEWANMDGTERSVLL 505
+ I MDG+ RSV++
Sbjct: 3167 HSLIGRIGMDGSSRSVIV 3184
Score = 88.2 bits (209), Expect = 2e-17
Identities = 55/154 (35%), Positives = 80/154 (51%), Gaps = 8/154 (5%)
Frame = +2
Query: 83 PREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPE 262
P E PI + ++ A+ + +G IY+ D S I R DG+E E L GI + E
Sbjct: 548 PDEHMIPIENLMNPRALDFHAE--TGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVE 605
Query: 263 GLAIDWSARNIFWT-DSKKLTIEVANLD--TKVRKVLFSVQNISNPRGIAVHPQRGKIFW 433
G+A+DW N++WT D K TI VA L+ + RK L +++PR I V P G ++W
Sbjct: 606 GVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIE-GKMTHPRAIVVDPLNGWMYW 664
Query: 434 TDWNRS-----NPKIEWANMDGTERSVLLGSPDV 520
TDW ++E A MDG+ R + + S V
Sbjct: 665 TDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTV 698
Score = 86.2 bits (204), Expect = 6e-17
Identities = 42/88 (47%), Positives = 56/88 (63%)
Frame = +2
Query: 242 TGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRG 421
+G+ P G+AIDW A N++WTDS + IEVA + + RK L S I P I V P RG
Sbjct: 3955 SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGM-IDEPHAIVVDPLRG 4013
Query: 422 KIFWTDWNRSNPKIEWANMDGTERSVLL 505
++W+DW ++PKIE A MDGT R L+
Sbjct: 4014 TMYWSDWG-NHPKIETAAMDGTLRETLV 4040
Score = 66.1 bits (154), Expect = 7e-11
Identities = 45/138 (32%), Positives = 74/138 (53%), Gaps = 2/138 (1%)
Frame = +2
Query: 104 INSGISQVAVSVSVDCFSGKIYWGDVVSNN-IKRAGYDGSEFEQFLNTGIISPEGLAIDW 280
++SG+ + V VD +G +YW D ++ I R G DGS ++T I P GL +D+
Sbjct: 3140 VSSGLREPRALV-VDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDY 3198
Query: 281 SARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
I+W D+++ IE A+LD R V+ S Q+I P A+ ++WTDW +
Sbjct: 3199 VTERIYWADAREDYIEFASLDGSNRHVVLS-QDI--PHIFALTLFEDYVYWTDWETKS-- 3253
Query: 461 IEWAN-MDGTERSVLLGS 511
I A+ GT +++L+ +
Sbjct: 3254 INRAHKTTGTNKTLLIST 3271
Score = 57.6 bits (133), Expect = 2e-08
Identities = 31/84 (36%), Positives = 48/84 (57%)
Frame = +2
Query: 260 EGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
E +AIDW N ++ D I V N + L ++ + NP+GIA+ P GK+F+TD
Sbjct: 283 EQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLE-LYNPKGIALDPAMGKVFFTD 341
Query: 440 WNRSNPKIEWANMDGTERSVLLGS 511
+ + PK+E +MDG R+ L+ S
Sbjct: 342 YGQI-PKVERCDMDGQNRTKLVDS 364
Score = 50.4 bits (115), Expect = 4e-06
Identities = 40/163 (24%), Positives = 75/163 (46%), Gaps = 2/163 (1%)
Frame = +2
Query: 23 GNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSN-NIK 199
GN T G + V + I+ G+ + +++V G ++W + I+
Sbjct: 1977 GNIYWTDQGFDVIEVARLNGSFRYVV-ISQGLDKPR-AITVHPEKGYLFWTEWGQYPRIE 2034
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDT-KVRKVLFSVQ 376
R+ DG+E +N I P G+++D+ ++W D++ IE +L+T + R+V+ S
Sbjct: 2035 RSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSN 2094
Query: 377 NISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
N+ +V I+W+D +N I+ + D SV L
Sbjct: 2095 NMDM---FSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPL 2134
Score = 50.4 bits (115), Expect = 4e-06
Identities = 29/115 (25%), Positives = 54/115 (46%), Gaps = 1/115 (0%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAID 277
T +N ++ +++D +G +YW D + I+ A G + ++ I P + +D
Sbjct: 3950 THLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVD 4009
Query: 278 WSARNIFWTD-SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
++W+D IE A +D +R+ L NI P G+AV +++W D
Sbjct: 4010 PLRGTMYWSDWGNHPKIETAAMDGTLRETLVQ-DNIQWPTGLAVDYHNERLYWAD 4063
Score = 50.0 bits (114), Expect = 5e-06
Identities = 40/138 (28%), Positives = 61/138 (44%)
Frame = +2
Query: 26 NFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRA 205
N TS T+ ++ F + G+ Q V V GK+YW D +NI A
Sbjct: 1671 NLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLV-VHPLRGKLYWTD--GDNISMA 1727
Query: 206 GYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNIS 385
DGS L +G P GLAID+ ++W S TI NLD +V+ ++++
Sbjct: 1728 NMDGSN-RTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRS-Q 1785
Query: 386 NPRGIAVHPQRGKIFWTD 439
+ A+ K++W D
Sbjct: 1786 LGKATALAIMGDKLWWAD 1803
Score = 50.0 bits (114), Expect = 5e-06
Identities = 29/86 (33%), Positives = 45/86 (52%)
Frame = +2
Query: 191 NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFS 370
+I RA G+ + I +P GLAID A ++++D+ IE D R V+
Sbjct: 2357 SIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILK 2416
Query: 371 VQNISNPRGIAVHPQRGKIFWTDWNR 448
+ + +P G+AV+ + IFWTDW R
Sbjct: 2417 SEPV-HPFGLAVYGEH--IFWTDWVR 2439
Score = 46.8 bits (106), Expect = 5e-05
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 5/120 (4%)
Frame = +2
Query: 161 KIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANL 340
+I++ D+ NI++ DGS + + S EGLA ++WT TI +
Sbjct: 2254 RIFFSDIHFGNIQQINDDGSRRITIVEN-VGSVEGLAYHRGWDTLYWTSYTTSTITRHTV 2312
Query: 341 DTK-----VRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
D R+ + ++ +PR + + +FWT+WN +P I A + G L+
Sbjct: 2313 DQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLI 2372
Score = 46.4 bits (105), Expect = 6e-05
Identities = 29/111 (26%), Positives = 57/111 (51%), Gaps = 8/111 (7%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-------NIKRAGYDGSEFEQFLNTG-IISPEGLAIDWSAR 289
++ VD +G +YW D + ++RA DGS + F+ + ++ P GL++D A
Sbjct: 652 AIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAG 711
Query: 290 NIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
++W D+ IE L+ RK+++ +++ G+ H +FWT++
Sbjct: 712 RLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHH--GNYLFWTEY 760
Score = 45.6 bits (103), Expect = 1e-04
Identities = 27/88 (30%), Positives = 42/88 (47%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
+++D + K+Y+ D + I+R YDGS L + + P GLA+ +IFWTD +
Sbjct: 2382 LAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAV--YGEHIFWTDWVR 2439
Query: 317 LTIEVANLDTKVRKVLFSVQNISNPRGI 400
++ AN L V P GI
Sbjct: 2440 RAVQRANKHVGSNMKLLRVDIPQQPMGI 2467
Score = 45.2 bits (102), Expect = 1e-04
Identities = 36/130 (27%), Positives = 56/130 (43%), Gaps = 2/130 (1%)
Frame = +2
Query: 23 GNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSN-NIK 199
GN T G + V E + SG+ ++ VD G +YW D ++ I+
Sbjct: 3970 GNVYWTDSGRDVIEVA--QMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIE 4027
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLD-TKVRKVLFSVQ 376
A DG+ E + I P GLA+D+ ++W D+K I L+ T S +
Sbjct: 4028 TAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKR 4087
Query: 377 NISNPRGIAV 406
+S+P I V
Sbjct: 4088 GLSHPFSIDV 4097
Score = 41.9 bits (94), Expect = 0.001
Identities = 22/91 (24%), Positives = 47/91 (51%), Gaps = 1/91 (1%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVS-NNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
+++D GK+++ D ++R DG + +++ I+ P G+ +D +R ++W D+
Sbjct: 328 IALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAY 387
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAV 406
IEV + + K R+ + I + G+ V
Sbjct: 388 LDYIEVVDYEGKGRQTIIQGILIEHLYGLTV 418
Score = 41.5 bits (93), Expect = 0.002
Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 3/104 (2%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWT--DS 310
++VD +G IYW + + I+ A DG+ L I P +A+D +FWT D+
Sbjct: 1349 LAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDA 1408
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISN-PRGIAVHPQRGKIFWTD 439
IE A++ R+ + P G+ V +I W D
Sbjct: 1409 SLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWID 1452
Score = 41.1 bits (92), Expect = 0.002
Identities = 24/102 (23%), Positives = 50/102 (49%), Gaps = 1/102 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
+++D +G Y+ D + + I +G L+ + +P+G+A+D + +F+TD +
Sbjct: 285 MAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQ 344
Query: 317 L-TIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
+ +E ++D + R L I P GI + ++W D
Sbjct: 345 IPKVERCDMDGQNRTKLVD-SKIVFPHGITLDLVSRLVYWAD 385
Score = 40.3 bits (90), Expect = 0.004
Identities = 21/67 (31%), Positives = 38/67 (56%), Gaps = 1/67 (1%)
Frame = +2
Query: 257 PEGLAIDWSARNIFWTDSKKLTIEVANLD-TKVRKVLFSVQNISNPRGIAVHPQRGKIFW 433
P GL +D+ + I W D++ I A D + +VL + +S+P + ++ G+++W
Sbjct: 1436 PNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLY--GGEVYW 1493
Query: 434 TDWNRSN 454
TDW R+N
Sbjct: 1494 TDW-RTN 1499
Score = 36.7 bits (81), Expect = 0.049
Identities = 21/81 (25%), Positives = 46/81 (56%), Gaps = 3/81 (3%)
Frame = +2
Query: 272 IDWSARN--IFWTDSKKLTIEVANLD-TKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
+D+ AR ++W+D + I+ A ++ T V V+ + ++ N G+AV +FWT +
Sbjct: 1620 LDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSA--DLPNAHGLAVDWVSRNLFWTSY 1677
Query: 443 NRSNPKIEWANMDGTERSVLL 505
+ + +I A +DG+ ++ ++
Sbjct: 1678 DTNKKQINVARLDGSFKNAVV 1698
Score = 35.5 bits (78), Expect = 0.11
Identities = 27/95 (28%), Positives = 40/95 (42%), Gaps = 1/95 (1%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
++VD +I W D S+ I A YDGS + L A+ ++WTD +
Sbjct: 1439 LTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRT 1498
Query: 317 LTIEVANLDTKVRKVLFSVQNISNPRGIAV-HPQR 418
T+ AN T + N + P + V HP R
Sbjct: 1499 NTLAKANKWTGHNVTVVQRTN-TQPFDLQVYHPSR 1532
Score = 34.7 bits (76), Expect = 0.20
Identities = 17/46 (36%), Positives = 24/46 (52%)
Frame = +2
Query: 368 SVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
++ + PRGIA+ G ++WTD R IE A M G R L+
Sbjct: 3953 NISGLKMPRGIAIDWVAGNVYWTDSGRD--VIEVAQMKGENRKTLI 3996
>DQ314873-1|ABC40732.1| 4544|Homo sapiens low density
lipoprotein-related protein 1 (alpha-2-macroglobulin
receptor) protein.
Length = 4544
Score = 112 bits (270), Expect = 6e-25
Identities = 64/161 (39%), Positives = 91/161 (56%)
Frame = +2
Query: 23 GNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKR 202
G+FL+ S I +P + + A SG S +AV + + IYW D+ + I R
Sbjct: 1890 GSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTS-LAVGIDFHAENDTIYWVDMGLSTISR 1948
Query: 203 AGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNI 382
A D + E + GI EG+A+DW A NI+WTD IEVA L+ R V+ S Q +
Sbjct: 1949 AKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVIS-QGL 2007
Query: 383 SNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
PR I VHP++G +FWT+W + P+IE + +DGTER VL+
Sbjct: 2008 DKPRAITVHPEKGYLFWTEWGQ-YPRIERSRLDGTERVVLV 2047
Score = 99.1 bits (236), Expect = 8e-21
Identities = 51/114 (44%), Positives = 71/114 (62%), Gaps = 4/114 (3%)
Frame = +2
Query: 164 IYWGDVVSNNIKRAGY--DGS--EFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEV 331
+YW DVV + I R +G+ FE + G+ +PEGLA+DW A NI+W +S IEV
Sbjct: 1311 LYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEV 1370
Query: 332 ANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTER 493
A LD +R L + +I +PR IA+ P+ G +FWTDW+ S P+IE A+M G R
Sbjct: 1371 AKLDGTLRTTLLA-GDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGR 1423
Score = 99.1 bits (236), Expect = 8e-21
Identities = 52/131 (39%), Positives = 75/131 (57%), Gaps = 2/131 (1%)
Frame = +2
Query: 116 ISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
I V V + D ++YW DV + IKRA +G+ E ++ + + GLA+DW +RN+
Sbjct: 1614 IDNVTV-LDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNL 1672
Query: 296 FWT--DSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEW 469
FWT D+ K I VA LD + + VQ + P G+ VHP RGK++WTD I
Sbjct: 1673 FWTSYDTNKKQINVARLDGSFKNAV--VQGLEQPHGLVVHPLRGKLYWTD----GDNISM 1726
Query: 470 ANMDGTERSVL 502
ANMDG+ R++L
Sbjct: 1727 ANMDGSNRTLL 1737
Score = 93.1 bits (221), Expect = 5e-19
Identities = 50/138 (36%), Positives = 76/138 (55%), Gaps = 2/138 (1%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSNN--IKRAGYDGSEFEQFLNTGIISPEGLA 271
T + G++ AV++ D IYW DV + I+R +GS + TG+ +P+GLA
Sbjct: 3050 TLLKQGLNN-AVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLA 3108
Query: 272 IDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRS 451
+DW N++W D + TIEV+ L+ R VL S + PR + V Q G ++WTDW
Sbjct: 3109 VDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVS-SGLREPRALVVDVQNGYLYWTDWG-D 3166
Query: 452 NPKIEWANMDGTERSVLL 505
+ I MDG+ RSV++
Sbjct: 3167 HSLIGRIGMDGSSRSVIV 3184
Score = 88.2 bits (209), Expect = 2e-17
Identities = 55/154 (35%), Positives = 80/154 (51%), Gaps = 8/154 (5%)
Frame = +2
Query: 83 PREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPE 262
P E PI + ++ A+ + +G IY+ D S I R DG+E E L GI + E
Sbjct: 548 PDEHMIPIENLMNPRALDFHAE--TGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVE 605
Query: 263 GLAIDWSARNIFWT-DSKKLTIEVANLD--TKVRKVLFSVQNISNPRGIAVHPQRGKIFW 433
G+A+DW N++WT D K TI VA L+ + RK L +++PR I V P G ++W
Sbjct: 606 GVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIE-GKMTHPRAIVVDPLNGWMYW 664
Query: 434 TDWNRS-----NPKIEWANMDGTERSVLLGSPDV 520
TDW ++E A MDG+ R + + S V
Sbjct: 665 TDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTV 698
Score = 86.2 bits (204), Expect = 6e-17
Identities = 42/88 (47%), Positives = 56/88 (63%)
Frame = +2
Query: 242 TGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRG 421
+G+ P G+AIDW A N++WTDS + IEVA + + RK L S I P I V P RG
Sbjct: 3955 SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGM-IDEPHAIVVDPLRG 4013
Query: 422 KIFWTDWNRSNPKIEWANMDGTERSVLL 505
++W+DW ++PKIE A MDGT R L+
Sbjct: 4014 TMYWSDWG-NHPKIETAAMDGTLRETLV 4040
Score = 66.1 bits (154), Expect = 7e-11
Identities = 45/138 (32%), Positives = 74/138 (53%), Gaps = 2/138 (1%)
Frame = +2
Query: 104 INSGISQVAVSVSVDCFSGKIYWGDVVSNN-IKRAGYDGSEFEQFLNTGIISPEGLAIDW 280
++SG+ + V VD +G +YW D ++ I R G DGS ++T I P GL +D+
Sbjct: 3140 VSSGLREPRALV-VDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDY 3198
Query: 281 SARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
I+W D+++ IE A+LD R V+ S Q+I P A+ ++WTDW +
Sbjct: 3199 VTERIYWADAREDYIEFASLDGSNRHVVLS-QDI--PHIFALTLFEDYVYWTDWETKS-- 3253
Query: 461 IEWAN-MDGTERSVLLGS 511
I A+ GT +++L+ +
Sbjct: 3254 INRAHKTTGTNKTLLIST 3271
Score = 57.6 bits (133), Expect = 2e-08
Identities = 31/84 (36%), Positives = 48/84 (57%)
Frame = +2
Query: 260 EGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
E +AIDW N ++ D I V N + L ++ + NP+GIA+ P GK+F+TD
Sbjct: 283 EQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLE-LYNPKGIALDPAMGKVFFTD 341
Query: 440 WNRSNPKIEWANMDGTERSVLLGS 511
+ + PK+E +MDG R+ L+ S
Sbjct: 342 YGQI-PKVERCDMDGQNRTKLVDS 364
Score = 50.4 bits (115), Expect = 4e-06
Identities = 40/163 (24%), Positives = 75/163 (46%), Gaps = 2/163 (1%)
Frame = +2
Query: 23 GNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSN-NIK 199
GN T G + V + I+ G+ + +++V G ++W + I+
Sbjct: 1977 GNIYWTDQGFDVIEVARLNGSFRYVV-ISQGLDKPR-AITVHPEKGYLFWTEWGQYPRIE 2034
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDT-KVRKVLFSVQ 376
R+ DG+E +N I P G+++D+ ++W D++ IE +L+T + R+V+ S
Sbjct: 2035 RSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSN 2094
Query: 377 NISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
N+ +V I+W+D +N I+ + D SV L
Sbjct: 2095 NMDM---FSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPL 2134
Score = 50.4 bits (115), Expect = 4e-06
Identities = 29/115 (25%), Positives = 54/115 (46%), Gaps = 1/115 (0%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAID 277
T +N ++ +++D +G +YW D + I+ A G + ++ I P + +D
Sbjct: 3950 THLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVD 4009
Query: 278 WSARNIFWTD-SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
++W+D IE A +D +R+ L NI P G+AV +++W D
Sbjct: 4010 PLRGTMYWSDWGNHPKIETAAMDGTLRETLVQ-DNIQWPTGLAVDYHNERLYWAD 4063
Score = 50.0 bits (114), Expect = 5e-06
Identities = 40/138 (28%), Positives = 61/138 (44%)
Frame = +2
Query: 26 NFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRA 205
N TS T+ ++ F + G+ Q V V GK+YW D +NI A
Sbjct: 1671 NLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLV-VHPLRGKLYWTD--GDNISMA 1727
Query: 206 GYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNIS 385
DGS L +G P GLAID+ ++W S TI NLD +V+ ++++
Sbjct: 1728 NMDGSN-RTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRS-Q 1785
Query: 386 NPRGIAVHPQRGKIFWTD 439
+ A+ K++W D
Sbjct: 1786 LGKATALAIMGDKLWWAD 1803
Score = 50.0 bits (114), Expect = 5e-06
Identities = 29/86 (33%), Positives = 45/86 (52%)
Frame = +2
Query: 191 NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFS 370
+I RA G+ + I +P GLAID A ++++D+ IE D R V+
Sbjct: 2357 SIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILK 2416
Query: 371 VQNISNPRGIAVHPQRGKIFWTDWNR 448
+ + +P G+AV+ + IFWTDW R
Sbjct: 2417 SEPV-HPFGLAVYGEH--IFWTDWVR 2439
Score = 46.8 bits (106), Expect = 5e-05
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 5/120 (4%)
Frame = +2
Query: 161 KIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANL 340
+I++ D+ NI++ DGS + + S EGLA ++WT TI +
Sbjct: 2254 RIFFSDIHFGNIQQINDDGSRRITIVEN-VGSVEGLAYHRGWDTLYWTSYTTSTITRHTV 2312
Query: 341 DTK-----VRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
D R+ + ++ +PR + + +FWT+WN +P I A + G L+
Sbjct: 2313 DQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLI 2372
Score = 46.4 bits (105), Expect = 6e-05
Identities = 29/111 (26%), Positives = 57/111 (51%), Gaps = 8/111 (7%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-------NIKRAGYDGSEFEQFLNTG-IISPEGLAIDWSAR 289
++ VD +G +YW D + ++RA DGS + F+ + ++ P GL++D A
Sbjct: 652 AIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAG 711
Query: 290 NIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
++W D+ IE L+ RK+++ +++ G+ H +FWT++
Sbjct: 712 RLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHH--GNYLFWTEY 760
Score = 45.6 bits (103), Expect = 1e-04
Identities = 27/88 (30%), Positives = 42/88 (47%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
+++D + K+Y+ D + I+R YDGS L + + P GLA+ +IFWTD +
Sbjct: 2382 LAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAV--YGEHIFWTDWVR 2439
Query: 317 LTIEVANLDTKVRKVLFSVQNISNPRGI 400
++ AN L V P GI
Sbjct: 2440 RAVQRANKHVGSNMKLLRVDIPQQPMGI 2467
Score = 45.2 bits (102), Expect = 1e-04
Identities = 36/130 (27%), Positives = 56/130 (43%), Gaps = 2/130 (1%)
Frame = +2
Query: 23 GNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSN-NIK 199
GN T G + V E + SG+ ++ VD G +YW D ++ I+
Sbjct: 3970 GNVYWTDSGRDVIEVA--QMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIE 4027
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLD-TKVRKVLFSVQ 376
A DG+ E + I P GLA+D+ ++W D+K I L+ T S +
Sbjct: 4028 TAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKR 4087
Query: 377 NISNPRGIAV 406
+S+P I V
Sbjct: 4088 GLSHPFSIDV 4097
Score = 41.9 bits (94), Expect = 0.001
Identities = 22/91 (24%), Positives = 47/91 (51%), Gaps = 1/91 (1%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVS-NNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
+++D GK+++ D ++R DG + +++ I+ P G+ +D +R ++W D+
Sbjct: 328 IALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAY 387
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAV 406
IEV + + K R+ + I + G+ V
Sbjct: 388 LDYIEVVDYEGKGRQTIIQGILIEHLYGLTV 418
Score = 41.5 bits (93), Expect = 0.002
Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 3/104 (2%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWT--DS 310
++VD +G IYW + + I+ A DG+ L I P +A+D +FWT D+
Sbjct: 1349 LAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDA 1408
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISN-PRGIAVHPQRGKIFWTD 439
IE A++ R+ + P G+ V +I W D
Sbjct: 1409 SLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWID 1452
Score = 41.1 bits (92), Expect = 0.002
Identities = 24/102 (23%), Positives = 50/102 (49%), Gaps = 1/102 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
+++D +G Y+ D + + I +G L+ + +P+G+A+D + +F+TD +
Sbjct: 285 MAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQ 344
Query: 317 L-TIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
+ +E ++D + R L I P GI + ++W D
Sbjct: 345 IPKVERCDMDGQNRTKLVD-SKIVFPHGITLDLVSRLVYWAD 385
Score = 40.3 bits (90), Expect = 0.004
Identities = 21/67 (31%), Positives = 38/67 (56%), Gaps = 1/67 (1%)
Frame = +2
Query: 257 PEGLAIDWSARNIFWTDSKKLTIEVANLD-TKVRKVLFSVQNISNPRGIAVHPQRGKIFW 433
P GL +D+ + I W D++ I A D + +VL + +S+P + ++ G+++W
Sbjct: 1436 PNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLY--GGEVYW 1493
Query: 434 TDWNRSN 454
TDW R+N
Sbjct: 1494 TDW-RTN 1499
Score = 36.7 bits (81), Expect = 0.049
Identities = 21/81 (25%), Positives = 46/81 (56%), Gaps = 3/81 (3%)
Frame = +2
Query: 272 IDWSARN--IFWTDSKKLTIEVANLD-TKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
+D+ AR ++W+D + I+ A ++ T V V+ + ++ N G+AV +FWT +
Sbjct: 1620 LDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSA--DLPNAHGLAVDWVSRNLFWTSY 1677
Query: 443 NRSNPKIEWANMDGTERSVLL 505
+ + +I A +DG+ ++ ++
Sbjct: 1678 DTNKKQINVARLDGSFKNAVV 1698
Score = 35.5 bits (78), Expect = 0.11
Identities = 27/95 (28%), Positives = 40/95 (42%), Gaps = 1/95 (1%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
++VD +I W D S+ I A YDGS + L A+ ++WTD +
Sbjct: 1439 LTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRT 1498
Query: 317 LTIEVANLDTKVRKVLFSVQNISNPRGIAV-HPQR 418
T+ AN T + N + P + V HP R
Sbjct: 1499 NTLAKANKWTGHNVTVVQRTN-TQPFDLQVYHPSR 1532
Score = 34.7 bits (76), Expect = 0.20
Identities = 17/46 (36%), Positives = 24/46 (52%)
Frame = +2
Query: 368 SVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
++ + PRGIA+ G ++WTD R IE A M G R L+
Sbjct: 3953 NISGLKMPRGIAIDWVAGNVYWTDSGRD--VIEVAQMKGENRKTLI 3996
>AF058427-1|AAC64265.1| 4544|Homo sapiens lipoprotein receptor-related
protein protein.
Length = 4544
Score = 112 bits (270), Expect = 6e-25
Identities = 64/161 (39%), Positives = 91/161 (56%)
Frame = +2
Query: 23 GNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKR 202
G+FL+ S I +P + + A SG S +AV + + IYW D+ + I R
Sbjct: 1890 GSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTS-LAVGIDFHAENDTIYWVDMGLSTISR 1948
Query: 203 AGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNI 382
A D + E + GI EG+A+DW A NI+WTD IEVA L+ R V+ S Q +
Sbjct: 1949 AKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVIS-QGL 2007
Query: 383 SNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
PR I VHP++G +FWT+W + P+IE + +DGTER VL+
Sbjct: 2008 DKPRAITVHPEKGYLFWTEWGQ-YPRIERSRLDGTERVVLV 2047
Score = 99.1 bits (236), Expect = 8e-21
Identities = 51/114 (44%), Positives = 71/114 (62%), Gaps = 4/114 (3%)
Frame = +2
Query: 164 IYWGDVVSNNIKRAGY--DGS--EFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEV 331
+YW DVV + I R +G+ FE + G+ +PEGLA+DW A NI+W +S IEV
Sbjct: 1311 LYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEV 1370
Query: 332 ANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTER 493
A LD +R L + +I +PR IA+ P+ G +FWTDW+ S P+IE A+M G R
Sbjct: 1371 AKLDGTLRTTLLA-GDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGR 1423
Score = 99.1 bits (236), Expect = 8e-21
Identities = 52/131 (39%), Positives = 75/131 (57%), Gaps = 2/131 (1%)
Frame = +2
Query: 116 ISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
I V V + D ++YW DV + IKRA +G+ E ++ + + GLA+DW +RN+
Sbjct: 1614 IDNVTV-LDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNL 1672
Query: 296 FWT--DSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEW 469
FWT D+ K I VA LD + + VQ + P G+ VHP RGK++WTD I
Sbjct: 1673 FWTSYDTNKKQINVARLDGSFKNAV--VQGLEQPHGLVVHPLRGKLYWTD----GDNISM 1726
Query: 470 ANMDGTERSVL 502
ANMDG+ R++L
Sbjct: 1727 ANMDGSNRTLL 1737
Score = 93.1 bits (221), Expect = 5e-19
Identities = 50/138 (36%), Positives = 76/138 (55%), Gaps = 2/138 (1%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSNN--IKRAGYDGSEFEQFLNTGIISPEGLA 271
T + G++ AV++ D IYW DV + I+R +GS + TG+ +P+GLA
Sbjct: 3050 TLLKQGLNN-AVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLA 3108
Query: 272 IDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRS 451
+DW N++W D + TIEV+ L+ R VL S + PR + V Q G ++WTDW
Sbjct: 3109 VDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVS-SGLREPRALVVDVQNGYLYWTDWG-D 3166
Query: 452 NPKIEWANMDGTERSVLL 505
+ I MDG+ RSV++
Sbjct: 3167 HSLIGRIGMDGSSRSVIV 3184
Score = 88.2 bits (209), Expect = 2e-17
Identities = 55/154 (35%), Positives = 80/154 (51%), Gaps = 8/154 (5%)
Frame = +2
Query: 83 PREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPE 262
P E PI + ++ A+ + +G IY+ D S I R DG+E E L GI + E
Sbjct: 548 PDEHMIPIENLMNPRALDFHAE--TGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVE 605
Query: 263 GLAIDWSARNIFWT-DSKKLTIEVANLD--TKVRKVLFSVQNISNPRGIAVHPQRGKIFW 433
G+A+DW N++WT D K TI VA L+ + RK L +++PR I V P G ++W
Sbjct: 606 GVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIE-GKMTHPRAIVVDPLNGWMYW 664
Query: 434 TDWNRS-----NPKIEWANMDGTERSVLLGSPDV 520
TDW ++E A MDG+ R + + S V
Sbjct: 665 TDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTV 698
Score = 86.2 bits (204), Expect = 6e-17
Identities = 42/88 (47%), Positives = 56/88 (63%)
Frame = +2
Query: 242 TGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRG 421
+G+ P G+AIDW A N++WTDS + IEVA + + RK L S I P I V P RG
Sbjct: 3955 SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGM-IDEPHAIVVDPLRG 4013
Query: 422 KIFWTDWNRSNPKIEWANMDGTERSVLL 505
++W+DW ++PKIE A MDGT R L+
Sbjct: 4014 TMYWSDWG-NHPKIETAAMDGTLRETLV 4040
Score = 66.1 bits (154), Expect = 7e-11
Identities = 45/138 (32%), Positives = 74/138 (53%), Gaps = 2/138 (1%)
Frame = +2
Query: 104 INSGISQVAVSVSVDCFSGKIYWGDVVSNN-IKRAGYDGSEFEQFLNTGIISPEGLAIDW 280
++SG+ + V VD +G +YW D ++ I R G DGS ++T I P GL +D+
Sbjct: 3140 VSSGLREPRALV-VDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDY 3198
Query: 281 SARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
I+W D+++ IE A+LD R V+ S Q+I P A+ ++WTDW +
Sbjct: 3199 VTERIYWADAREDYIEFASLDGSNRHVVLS-QDI--PHIFALTLFEDYVYWTDWETKS-- 3253
Query: 461 IEWAN-MDGTERSVLLGS 511
I A+ GT +++L+ +
Sbjct: 3254 INRAHKTTGTNKTLLIST 3271
Score = 57.6 bits (133), Expect = 2e-08
Identities = 31/84 (36%), Positives = 48/84 (57%)
Frame = +2
Query: 260 EGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
E +AIDW N ++ D I V N + L ++ + NP+GIA+ P GK+F+TD
Sbjct: 283 EQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLE-LYNPKGIALDPAMGKVFFTD 341
Query: 440 WNRSNPKIEWANMDGTERSVLLGS 511
+ + PK+E +MDG R+ L+ S
Sbjct: 342 YGQI-PKVERCDMDGQNRTKLVDS 364
Score = 50.4 bits (115), Expect = 4e-06
Identities = 40/163 (24%), Positives = 75/163 (46%), Gaps = 2/163 (1%)
Frame = +2
Query: 23 GNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSN-NIK 199
GN T G + V + I+ G+ + +++V G ++W + I+
Sbjct: 1977 GNIYWTDQGFDVIEVARLNGSFRYVV-ISQGLDKPR-AITVHPEKGYLFWTEWGQYPRIE 2034
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDT-KVRKVLFSVQ 376
R+ DG+E +N I P G+++D+ ++W D++ IE +L+T + R+V+ S
Sbjct: 2035 RSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSN 2094
Query: 377 NISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
N+ +V I+W+D +N I+ + D SV L
Sbjct: 2095 NMDM---FSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPL 2134
Score = 50.4 bits (115), Expect = 4e-06
Identities = 29/115 (25%), Positives = 54/115 (46%), Gaps = 1/115 (0%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAID 277
T +N ++ +++D +G +YW D + I+ A G + ++ I P + +D
Sbjct: 3950 THLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVD 4009
Query: 278 WSARNIFWTD-SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
++W+D IE A +D +R+ L NI P G+AV +++W D
Sbjct: 4010 PLRGTMYWSDWGNHPKIETAAMDGTLRETLVQ-DNIQWPTGLAVDYHNERLYWAD 4063
Score = 50.0 bits (114), Expect = 5e-06
Identities = 40/138 (28%), Positives = 61/138 (44%)
Frame = +2
Query: 26 NFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRA 205
N TS T+ ++ F + G+ Q V V GK+YW D +NI A
Sbjct: 1671 NLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLV-VHPLRGKLYWTD--GDNISMA 1727
Query: 206 GYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNIS 385
DGS L +G P GLAID+ ++W S TI NLD +V+ ++++
Sbjct: 1728 NMDGSN-RTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRS-Q 1785
Query: 386 NPRGIAVHPQRGKIFWTD 439
+ A+ K++W D
Sbjct: 1786 LGKATALAIMGDKLWWAD 1803
Score = 50.0 bits (114), Expect = 5e-06
Identities = 29/86 (33%), Positives = 45/86 (52%)
Frame = +2
Query: 191 NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFS 370
+I RA G+ + I +P GLAID A ++++D+ IE D R V+
Sbjct: 2357 SIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILK 2416
Query: 371 VQNISNPRGIAVHPQRGKIFWTDWNR 448
+ + +P G+AV+ + IFWTDW R
Sbjct: 2417 SEPV-HPFGLAVYGEH--IFWTDWVR 2439
Score = 46.8 bits (106), Expect = 5e-05
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 5/120 (4%)
Frame = +2
Query: 161 KIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANL 340
+I++ D+ NI++ DGS + + S EGLA ++WT TI +
Sbjct: 2254 RIFFSDIHFGNIQQINDDGSRRITIVEN-VGSVEGLAYHRGWDTLYWTSYTTSTITRHTV 2312
Query: 341 DTK-----VRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
D R+ + ++ +PR + + +FWT+WN +P I A + G L+
Sbjct: 2313 DQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLI 2372
Score = 46.4 bits (105), Expect = 6e-05
Identities = 29/111 (26%), Positives = 57/111 (51%), Gaps = 8/111 (7%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-------NIKRAGYDGSEFEQFLNTG-IISPEGLAIDWSAR 289
++ VD +G +YW D + ++RA DGS + F+ + ++ P GL++D A
Sbjct: 652 AIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAG 711
Query: 290 NIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
++W D+ IE L+ RK+++ +++ G+ H +FWT++
Sbjct: 712 RLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHH--GNYLFWTEY 760
Score = 45.6 bits (103), Expect = 1e-04
Identities = 27/88 (30%), Positives = 42/88 (47%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
+++D + K+Y+ D + I+R YDGS L + + P GLA+ +IFWTD +
Sbjct: 2382 LAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAV--YGEHIFWTDWVR 2439
Query: 317 LTIEVANLDTKVRKVLFSVQNISNPRGI 400
++ AN L V P GI
Sbjct: 2440 RAVQRANKHVGSNMKLLRVDIPQQPMGI 2467
Score = 45.2 bits (102), Expect = 1e-04
Identities = 36/130 (27%), Positives = 56/130 (43%), Gaps = 2/130 (1%)
Frame = +2
Query: 23 GNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSN-NIK 199
GN T G + V E + SG+ ++ VD G +YW D ++ I+
Sbjct: 3970 GNVYWTDSGRDVIEVA--QMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIE 4027
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLD-TKVRKVLFSVQ 376
A DG+ E + I P GLA+D+ ++W D+K I L+ T S +
Sbjct: 4028 TAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKR 4087
Query: 377 NISNPRGIAV 406
+S+P I V
Sbjct: 4088 GLSHPFSIDV 4097
Score = 41.9 bits (94), Expect = 0.001
Identities = 22/91 (24%), Positives = 47/91 (51%), Gaps = 1/91 (1%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVS-NNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
+++D GK+++ D ++R DG + +++ I+ P G+ +D +R ++W D+
Sbjct: 328 IALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAY 387
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAV 406
IEV + + K R+ + I + G+ V
Sbjct: 388 LDYIEVVDYEGKGRQTIIQGILIEHLYGLTV 418
Score = 41.5 bits (93), Expect = 0.002
Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 3/104 (2%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWT--DS 310
++VD +G IYW + + I+ A DG+ L I P +A+D +FWT D+
Sbjct: 1349 LAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDA 1408
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISN-PRGIAVHPQRGKIFWTD 439
IE A++ R+ + P G+ V +I W D
Sbjct: 1409 SLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWID 1452
Score = 41.1 bits (92), Expect = 0.002
Identities = 24/102 (23%), Positives = 50/102 (49%), Gaps = 1/102 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
+++D +G Y+ D + + I +G L+ + +P+G+A+D + +F+TD +
Sbjct: 285 MAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQ 344
Query: 317 L-TIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
+ +E ++D + R L I P GI + ++W D
Sbjct: 345 IPKVERCDMDGQNRTKLVD-SKIVFPHGITLDLVSRLVYWAD 385
Score = 40.3 bits (90), Expect = 0.004
Identities = 21/67 (31%), Positives = 38/67 (56%), Gaps = 1/67 (1%)
Frame = +2
Query: 257 PEGLAIDWSARNIFWTDSKKLTIEVANLD-TKVRKVLFSVQNISNPRGIAVHPQRGKIFW 433
P GL +D+ + I W D++ I A D + +VL + +S+P + ++ G+++W
Sbjct: 1436 PNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLY--GGEVYW 1493
Query: 434 TDWNRSN 454
TDW R+N
Sbjct: 1494 TDW-RTN 1499
Score = 36.7 bits (81), Expect = 0.049
Identities = 21/81 (25%), Positives = 46/81 (56%), Gaps = 3/81 (3%)
Frame = +2
Query: 272 IDWSARN--IFWTDSKKLTIEVANLD-TKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
+D+ AR ++W+D + I+ A ++ T V V+ + ++ N G+AV +FWT +
Sbjct: 1620 LDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSA--DLPNAHGLAVDWVSRNLFWTSY 1677
Query: 443 NRSNPKIEWANMDGTERSVLL 505
+ + +I A +DG+ ++ ++
Sbjct: 1678 DTNKKQINVARLDGSFKNAVV 1698
Score = 35.5 bits (78), Expect = 0.11
Identities = 27/95 (28%), Positives = 40/95 (42%), Gaps = 1/95 (1%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
++VD +I W D S+ I A YDGS + L A+ ++WTD +
Sbjct: 1439 LTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRT 1498
Query: 317 LTIEVANLDTKVRKVLFSVQNISNPRGIAV-HPQR 418
T+ AN T + N + P + V HP R
Sbjct: 1499 NTLAKANKWTGHNVTVVQRTN-TQPFDLQVYHPSR 1532
Score = 34.7 bits (76), Expect = 0.20
Identities = 17/46 (36%), Positives = 24/46 (52%)
Frame = +2
Query: 368 SVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
++ + PRGIA+ G ++WTD R IE A M G R L+
Sbjct: 3953 NISGLKMPRGIAIDWVAGNVYWTDSGRD--VIEVAQMKGENRKTLI 3996
>AB209683-1|BAD92920.1| 1477|Homo sapiens low density lipoprotein
receptor-related protein 6 variant protein.
Length = 1477
Score = 111 bits (268), Expect = 1e-24
Identities = 57/162 (35%), Positives = 94/162 (58%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIK 199
P FL+ S I R+ + + A P+ +G+ + A ++ D +IYW D+ I
Sbjct: 494 PEAFLLFSRRADIRRISLETNNNNVAIPL-TGVKE-ASALDFDVTDNRIYWTDISLKTIS 551
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
RA +GS E + G+ PEG+A+DW +N++W D+ IEV+ LD + R+VL ++
Sbjct: 552 RAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLV-WKD 610
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ +PR +A+ P G ++WT+W PKI+ A MDG+ER+ L+
Sbjct: 611 LDSPRALALDPAEGFMYWTEWG-GKPKIDRAAMDGSERTTLV 651
Score = 106 bits (255), Expect = 4e-23
Identities = 51/128 (39%), Positives = 78/128 (60%)
Frame = +2
Query: 128 AVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
A+++ D G IYW D I+R+ DGS + + I P+G+A+DW ARN++WTD
Sbjct: 226 AIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTD 285
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ IEV L+ +RK+L S +++ PR I + P G ++WTDW PKIE A +DG+
Sbjct: 286 TGTDRIEVTRLNGTMRKILIS-EDLEEPRAIVLDPMVGYMYWTDWGEI-PKIERAALDGS 343
Query: 488 ERSVLLGS 511
+R VL+ +
Sbjct: 344 DRVVLVNT 351
Score = 75.8 bits (178), Expect = 9e-14
Identities = 56/172 (32%), Positives = 89/172 (51%), Gaps = 8/172 (4%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPF--KYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNN 193
P FL+ S ++I R+ + SP + PI+S + V ++ D ++YW D N
Sbjct: 796 PTTFLLFSQKSAINRMVIDEQQSP-DIILPIHS-LRNVR-AIDYDPLDKQLYWIDSRQNM 852
Query: 194 IKRAGYDGSEFEQFLNTGI------ISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVR 355
I++A DGS+ + + + I P L+ID +R I+WT I V LD +
Sbjct: 853 IRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 912
Query: 356 KVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
V+ + PR I V+P++G +++T+ +PKIE A +DGTER VL S
Sbjct: 913 GVVLKGEQ-DRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFS 963
Score = 65.7 bits (153), Expect = 9e-11
Identities = 44/131 (33%), Positives = 66/131 (50%), Gaps = 2/131 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVS-NNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ +D G +YW D I+RA DGS+ +NT + P GLA+D+ I+W D+
Sbjct: 314 AIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDA 373
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTE 490
K IEV N D R+VL I + G + ++WTDW R + IE + E
Sbjct: 374 KTDKIEVMNTDGTGRRVLVE-DKIPHIFGFTL--LGDYVYWTDWQRRS--IERVHKRSAE 428
Query: 491 RSVLLGS-PDV 520
R V++ PD+
Sbjct: 429 REVIIDQLPDL 439
Score = 60.5 bits (140), Expect = 3e-09
Identities = 35/105 (33%), Positives = 56/105 (53%), Gaps = 1/105 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVS-NNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++D SG +YW D I+RAG DGS +N+ I P GL +D+ + ++W D+
Sbjct: 6 AIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADA 65
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
K I +NLD R+ +V S P A+ ++WTDW+
Sbjct: 66 KLNFIHKSNLDGTNRQ---AVVKGSLPHPFALTLFEDILYWTDWS 107
Score = 58.0 bits (134), Expect = 2e-08
Identities = 41/130 (31%), Positives = 68/130 (52%), Gaps = 2/130 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++++D G +YW + I RA DGSE L + GL ID++ R ++WTD
Sbjct: 616 ALALDPAEGFMYWTEWGGKPKIDRAAMDGSE-RTTLVPNVGRANGLTIDYAKRRLYWTDL 674
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGT 487
IE +N+ R+V+ ++ +P G+ + + I+WTDW+R + IE AN G
Sbjct: 675 DTNLIESSNMLGLNREVI--ADDLPHPFGLTQY--QDYIYWTDWSRRS--IERANKTSGQ 728
Query: 488 ERSVLLGSPD 517
R+++ G D
Sbjct: 729 NRTIIQGHLD 738
Score = 49.2 bits (112), Expect = 9e-06
Identities = 32/102 (31%), Positives = 49/102 (48%)
Frame = +2
Query: 185 SNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVL 364
S I+RA DG+E E +G+ P LA+D +FW DS IE ++L + +++
Sbjct: 944 SPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDL-SGANRIV 1002
Query: 365 FSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTE 490
NI P G+ V ++W D + IE +M G E
Sbjct: 1003 LEDSNILQPVGLTVF--ENWLYWID--KQQQMIEKIDMTGRE 1040
Score = 48.0 bits (109), Expect = 2e-05
Identities = 20/44 (45%), Positives = 28/44 (63%)
Frame = +2
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
+ PR IA+ P G ++WTDW PKIE A MDG+ R +++ S
Sbjct: 1 LDQPRAIALDPSSGFMYWTDWGEV-PKIERAGMDGSSRFIIINS 43
Score = 40.7 bits (91), Expect = 0.003
Identities = 27/87 (31%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Frame = +2
Query: 257 PEGLAIDWSARNIFWTDSKKL-TIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFW 433
P +A+D S+ ++WTD ++ IE A +D R ++ + I P G+ + + K++W
Sbjct: 4 PRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIIN-SEIYWPNGLTLDYEEQKLYW 62
Query: 434 TDWNRSNPKIEWANMDGTER-SVLLGS 511
D + I +N+DGT R +V+ GS
Sbjct: 63 ADAKLN--FIHKSNLDGTNRQAVVKGS 87
Score = 33.9 bits (74), Expect = 0.35
Identities = 19/75 (25%), Positives = 40/75 (53%), Gaps = 2/75 (2%)
Frame = +2
Query: 110 SGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAI--DWS 283
SG+S+ +++++D GK++W D I+ + G+ ++ I+ P GL + +W
Sbjct: 963 SGLSK-PIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENW- 1020
Query: 284 ARNIFWTDSKKLTIE 328
++W D ++ IE
Sbjct: 1021 ---LYWIDKQQQMIE 1032
>AF283374-1|AAL38108.1| 1731|Homo sapiens candidate tumor suppressor
protein protein.
Length = 1731
Score = 108 bits (260), Expect = 1e-23
Identities = 63/160 (39%), Positives = 89/160 (55%)
Frame = +2
Query: 26 NFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRA 205
+FL+ S I +P + S + A SG S AV + + IYW D+ N I RA
Sbjct: 955 SFLMYSVHEGIRGIPLEPSDKMDALMPISGTS-FAVGIDFHAENDTIYWTDMGFNKISRA 1013
Query: 206 GYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNIS 385
D + E + G+ EG+A+DW A NI+WTD IEVA L+ R V+ S Q +
Sbjct: 1014 KRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIIS-QGLD 1072
Query: 386 NPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
PR IAVHP++G +FWT+W + P I A +DG+E+ VL+
Sbjct: 1073 QPRSIAVHPEKGLLFWTEWGQM-PCIGKARLDGSEKVVLV 1111
Score = 94.3 bits (224), Expect = 2e-19
Identities = 48/117 (41%), Positives = 67/117 (57%), Gaps = 4/117 (3%)
Frame = +2
Query: 164 IYWGDVVSNNIKRAGYDGS----EFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEV 331
+YW DVV + I R S E + G+ +PEGL +DW A NI+W DS IEV
Sbjct: 378 LYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEV 437
Query: 332 ANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVL 502
A LD +R L + + +PR IA+ P+ G +FWTDW+ + P+IE A+M G R +
Sbjct: 438 AKLDGSLRTTLIA-GAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTI 493
Score = 90.6 bits (215), Expect = 3e-18
Identities = 48/131 (36%), Positives = 73/131 (55%), Gaps = 2/131 (1%)
Frame = +2
Query: 116 ISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
I V V + D ++YW D+ + IKRA +G+ E ++ I S GLA+DW +RN+
Sbjct: 681 IDDVTV-IDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNL 739
Query: 296 FWTDSK--KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEW 469
+W S+ + I VA LD ++ + + I P+ +A HP RGK++WTD N I
Sbjct: 740 YWISSEFDETQINVARLDGSLKTSI--IHGIDKPQCLAAHPVRGKLYWTDGN----TINM 793
Query: 470 ANMDGTERSVL 502
ANMDG+ +L
Sbjct: 794 ANMDGSNSKIL 804
Score = 47.6 bits (108), Expect = 3e-05
Identities = 41/158 (25%), Positives = 72/158 (45%), Gaps = 2/158 (1%)
Frame = +2
Query: 23 GNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNN-IK 199
GN T G ++ V + I+ G+ Q S++V G ++W + I
Sbjct: 1041 GNIYWTDHGFNLIEVARLNGSFRYVI-ISQGLDQPR-SIAVHPEKGLLFWTEWGQMPCIG 1098
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
+A DGSE ++ GI P G++ID+ ++W D++ IE +L+T + + V +
Sbjct: 1099 KARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREM--VLS 1156
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANM-DGTE 490
SN +V I+W+D +N + + D TE
Sbjct: 1157 GSNVDMFSVAXFGAYIYWSDRAHANGSVRRGHKNDATE 1194
Score = 47.2 bits (107), Expect = 3e-05
Identities = 38/120 (31%), Positives = 59/120 (49%), Gaps = 3/120 (2%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWT--DS 310
++VD +G IYW D + I+ A DGS + + P +A+D +FWT D+
Sbjct: 416 LTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDA 475
Query: 311 KKLTIEVANLDTKVRKVLF-SVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
IE A++ RK ++ ++ + P G+ V +I WTD RS+ I A DGT
Sbjct: 476 NFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTD-ARSD-AIYSALYDGT 533
Score = 46.8 bits (106), Expect = 5e-05
Identities = 31/96 (32%), Positives = 45/96 (46%)
Frame = +2
Query: 158 GKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVAN 337
GK+YW D N I A DGS + L P GL+ID+ ++W S TI N
Sbjct: 781 GKLYWTD--GNTINMANMDGSN-SKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCN 837
Query: 338 LDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
LD +V+ S++ + A+ K++W D N
Sbjct: 838 LDGGNLEVIESMKE-ELTKATALTIMDKKLWWADQN 872
Score = 45.6 bits (103), Expect = 1e-04
Identities = 30/124 (24%), Positives = 59/124 (47%), Gaps = 5/124 (4%)
Frame = +2
Query: 155 SGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
+ +I++ D NI+ D E Q + + S EGLA + ++WT S +I
Sbjct: 1314 TNRIFYSDAHFGNIQLIK-DNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRH 1372
Query: 335 NLD-TKV----RKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSV 499
+D T+ R+ + ++ +P +A+ + +FWT+WN +P I + + G V
Sbjct: 1373 TVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQV 1432
Query: 500 LLGS 511
++ +
Sbjct: 1433 VVST 1436
Score = 44.4 bits (100), Expect = 2e-04
Identities = 35/141 (24%), Positives = 70/141 (49%), Gaps = 6/141 (4%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSN--NIKRAGYDGSEFEQF---LNTGIISPE 262
T + +G + ++++D G ++W D +N I+ A G+ + + TG P
Sbjct: 446 TTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAW-PN 504
Query: 263 GLAIDWSARNIFWTDSKKLTIEVANLD-TKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
GL +D + I WTD++ I A D T + +++ + +S+P ++++ +++WTD
Sbjct: 505 GLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGS--EVYWTD 562
Query: 440 WNRSNPKIEWANMDGTERSVL 502
W R+N + G SV+
Sbjct: 563 W-RTNTLSKANKWTGQNVSVI 582
Score = 42.7 bits (96), Expect = 8e-04
Identities = 25/86 (29%), Positives = 41/86 (47%)
Frame = +2
Query: 191 NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFS 370
+I R+ G + ++T I++P GL ID+ A ++++D IE D R V+
Sbjct: 1419 SIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVK 1478
Query: 371 VQNISNPRGIAVHPQRGKIFWTDWNR 448
+AV+ IFW+DW R
Sbjct: 1479 -SGPGTFLSLAVYD--NYIFWSDWGR 1501
Score = 35.5 bits (78), Expect = 0.11
Identities = 21/81 (25%), Positives = 41/81 (50%)
Frame = +2
Query: 275 DWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSN 454
D S ++WTD K TI+ A ++ + + S ++I + RG+AV ++W
Sbjct: 690 DASEERLYWTDIKTQTIKRAFINGTGLETVIS-RDIQSIRGLAVDWVSRNLYWISSEFDE 748
Query: 455 PKIEWANMDGTERSVLLGSPD 517
+I A +DG+ ++ ++ D
Sbjct: 749 TQINVARLDGSLKTSIIHGID 769
Score = 29.1 bits (62), Expect = 9.9
Identities = 14/59 (23%), Positives = 24/59 (40%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
V +S+D K+YW + I R DG E + + A+ + ++W D
Sbjct: 812 VGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWAD 870
Score = 29.1 bits (62), Expect = 9.9
Identities = 17/57 (29%), Positives = 30/57 (52%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
+++D + K+Y+ D I+R YDGS+ + +G + LA+ IFW+D
Sbjct: 1444 LTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAV--YDNYIFWSD 1498
>AF176832-1|AAF70379.1| 4599|Homo sapiens low density lipoprotein
receptor related protein-deleted in tumor protein.
Length = 4599
Score = 108 bits (260), Expect = 1e-23
Identities = 63/160 (39%), Positives = 89/160 (55%)
Frame = +2
Query: 26 NFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRA 205
+FL+ S I +P + S + A SG S AV + + IYW D+ N I RA
Sbjct: 1879 SFLMYSVHEGIRGIPLEPSDKMDALMPISGTS-FAVGIDFHAENDTIYWTDMGFNKISRA 1937
Query: 206 GYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNIS 385
D + E + G+ EG+A+DW A NI+WTD IEVA L+ R V+ S Q +
Sbjct: 1938 KRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIIS-QGLD 1996
Query: 386 NPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
PR IAVHP++G +FWT+W + P I A +DG+E+ VL+
Sbjct: 1997 QPRSIAVHPEKGLLFWTEWGQM-PCIGKARLDGSEKVVLV 2035
Score = 94.3 bits (224), Expect = 2e-19
Identities = 48/117 (41%), Positives = 67/117 (57%), Gaps = 4/117 (3%)
Frame = +2
Query: 164 IYWGDVVSNNIKRAGYDGS----EFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEV 331
+YW DVV + I R S E + G+ +PEGL +DW A NI+W DS IEV
Sbjct: 1302 LYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEV 1361
Query: 332 ANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVL 502
A LD +R L + + +PR IA+ P+ G +FWTDW+ + P+IE A+M G R +
Sbjct: 1362 AKLDGSLRTTLIA-GAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTI 1417
Score = 90.6 bits (215), Expect = 3e-18
Identities = 48/131 (36%), Positives = 73/131 (55%), Gaps = 2/131 (1%)
Frame = +2
Query: 116 ISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
I V V + D ++YW D+ + IKRA +G+ E ++ I S GLA+DW +RN+
Sbjct: 1605 IDDVTV-IDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNL 1663
Query: 296 FWTDSK--KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEW 469
+W S+ + I VA LD ++ + + I P+ +A HP RGK++WTD N I
Sbjct: 1664 YWISSEFDETQINVARLDGSLKTSI--IHGIDKPQCLAAHPVRGKLYWTDGN----TINM 1717
Query: 470 ANMDGTERSVL 502
ANMDG+ +L
Sbjct: 1718 ANMDGSNSKIL 1728
Score = 85.0 bits (201), Expect = 1e-16
Identities = 53/149 (35%), Positives = 80/149 (53%), Gaps = 8/149 (5%)
Frame = +2
Query: 89 EFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGL 268
E+ PI + ++ A+ + + IY+ D S I R DG+E E L + + EG+
Sbjct: 547 EYMIPIENLVNPRALDFHAE--TNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGI 604
Query: 269 AIDWSARNIFWT-DSKKLTIEVANLD--TKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
A+DW N++WT D + TI VA L+ ++ RK L + +S+PRGI V P G ++WTD
Sbjct: 605 AVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGE-MSHPRGIVVDPVNGWMYWTD 663
Query: 440 WNR-----SNPKIEWANMDGTERSVLLGS 511
W S +IE A MDG R + + S
Sbjct: 664 WEEDEIDDSVGRIEKAWMDGFNRQIFVTS 692
Score = 75.8 bits (178), Expect = 9e-14
Identities = 45/139 (32%), Positives = 75/139 (53%), Gaps = 3/139 (2%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSNN---IKRAGYDGSEFEQFLNTGIISPEGL 268
T + G++ V +++ D IYW D N I R +GS+ + NT + P L
Sbjct: 3036 TLLKQGLNNV-IAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNAL 3092
Query: 269 AIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
A+DW +N++W+D++K IEV+ L+ +L S + + PR +++ PQ G ++W D
Sbjct: 3093 AVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVS-KRLKFPRDLSLDPQAGYLYWIDC-C 3150
Query: 449 SNPKIEWANMDGTERSVLL 505
P I MDGT +SV++
Sbjct: 3151 EYPHIGRVGMDGTNQSVVI 3169
Score = 55.2 bits (127), Expect = 1e-07
Identities = 30/82 (36%), Positives = 48/82 (58%)
Frame = +2
Query: 266 LAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
+AIDW RN+++ D I V N + V L ++ + NP+ IAV P GK+F+TD+
Sbjct: 288 MAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLE-LHNPKAIAVDPIAGKLFFTDYG 346
Query: 446 RSNPKIEWANMDGTERSVLLGS 511
+ K+E +MDG R+ ++ S
Sbjct: 347 -NVAKVERCDMDGMNRTRIIDS 367
Score = 54.0 bits (124), Expect = 3e-07
Identities = 30/109 (27%), Positives = 58/109 (53%), Gaps = 7/109 (6%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNI-------KRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
+ VD +G +YW D + I ++A DG + F+ + ++ P GL +D+ +
Sbjct: 650 IVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTL 709
Query: 296 FWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
+W D+ IE L+ RK+++S + +++P G++ H +FWTD+
Sbjct: 710 YWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHH--GNYVFWTDY 756
Score = 49.6 bits (113), Expect = 7e-06
Identities = 34/102 (33%), Positives = 48/102 (47%), Gaps = 1/102 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
+S+D +G +YW D +I R G DG+ + T I P L ID+ R ++W D
Sbjct: 3135 LSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADEN 3194
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
IE +N+D R V N P IA+ I+WTD
Sbjct: 3195 H--IEFSNMDGSHR---HKVPNQDIPGVIALTLFEDYIYWTD 3231
Score = 47.2 bits (107), Expect = 3e-05
Identities = 38/120 (31%), Positives = 59/120 (49%), Gaps = 3/120 (2%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWT--DS 310
++VD +G IYW D + I+ A DGS + + P +A+D +FWT D+
Sbjct: 1340 LTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDA 1399
Query: 311 KKLTIEVANLDTKVRKVLF-SVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
IE A++ RK ++ ++ + P G+ V +I WTD RS+ I A DGT
Sbjct: 1400 NFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTD-ARSD-AIYSALYDGT 1457
Score = 47.2 bits (107), Expect = 3e-05
Identities = 41/158 (25%), Positives = 72/158 (45%), Gaps = 2/158 (1%)
Frame = +2
Query: 23 GNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNN-IK 199
GN T G ++ V + I+ G+ Q S++V G ++W + I
Sbjct: 1965 GNIYWTDHGFNLIEVARLNGSFRYVI-ISQGLDQPR-SIAVHPEKGLLFWTEWGQMPCIG 2022
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
+A DGSE ++ GI P G++ID+ ++W D++ IE +L+T + + V +
Sbjct: 2023 KARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREM--VLS 2080
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANM-DGTE 490
SN +V I+W+D +N + + D TE
Sbjct: 2081 GSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATE 2118
Score = 46.8 bits (106), Expect = 5e-05
Identities = 31/96 (32%), Positives = 45/96 (46%)
Frame = +2
Query: 158 GKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVAN 337
GK+YW D N I A DGS + L P GL+ID+ ++W S TI N
Sbjct: 1705 GKLYWTD--GNTINMANMDGSN-SKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCN 1761
Query: 338 LDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
LD +V+ S++ + A+ K++W D N
Sbjct: 1762 LDGGNLEVIESMKE-ELTKATALTIMDKKLWWADQN 1796
Score = 46.8 bits (106), Expect = 5e-05
Identities = 35/108 (32%), Positives = 53/108 (49%), Gaps = 19/108 (17%)
Frame = +2
Query: 239 NTGIISPE-----GLAIDWSARNIFWTDSKKL------TIEVANLDTKVRKVLFSVQNIS 385
N+G+I PE +A+DW A NI+WTD ++ T +L + + N +
Sbjct: 3960 NSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCT 4019
Query: 386 N--------PRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
P IAV+P+RG ++WT + IE A MDGT R +L+
Sbjct: 4020 RLLTNMAGEPYAIAVNPKRGMMYWTVVG-DHSHIEEAAMDGTLRRILV 4066
Score = 45.6 bits (103), Expect = 1e-04
Identities = 30/124 (24%), Positives = 59/124 (47%), Gaps = 5/124 (4%)
Frame = +2
Query: 155 SGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
+ +I++ D NI+ D E Q + + S EGLA + ++WT S +I
Sbjct: 2238 TNRIFYSDAHFGNIQLIK-DNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRH 2296
Query: 335 NLD-TKV----RKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSV 499
+D T+ R+ + ++ +P +A+ + +FWT+WN +P I + + G V
Sbjct: 2297 TVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQV 2356
Query: 500 LLGS 511
++ +
Sbjct: 2357 VVST 2360
Score = 44.4 bits (100), Expect = 2e-04
Identities = 35/141 (24%), Positives = 70/141 (49%), Gaps = 6/141 (4%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSN--NIKRAGYDGSEFEQF---LNTGIISPE 262
T + +G + ++++D G ++W D +N I+ A G+ + + TG P
Sbjct: 1370 TTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAW-PN 1428
Query: 263 GLAIDWSARNIFWTDSKKLTIEVANLD-TKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
GL +D + I WTD++ I A D T + +++ + +S+P ++++ +++WTD
Sbjct: 1429 GLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGS--EVYWTD 1486
Query: 440 WNRSNPKIEWANMDGTERSVL 502
W R+N + G SV+
Sbjct: 1487 W-RTNTLSKANKWTGQNVSVI 1506
Score = 42.7 bits (96), Expect = 8e-04
Identities = 25/86 (29%), Positives = 41/86 (47%)
Frame = +2
Query: 191 NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFS 370
+I R+ G + ++T I++P GL ID+ A ++++D IE D R V+
Sbjct: 2343 SIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVK 2402
Query: 371 VQNISNPRGIAVHPQRGKIFWTDWNR 448
+AV+ IFW+DW R
Sbjct: 2403 -SGPGTFLSLAVYD--NYIFWSDWGR 2425
Score = 40.7 bits (91), Expect = 0.003
Identities = 27/100 (27%), Positives = 53/100 (53%), Gaps = 1/100 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSNN-IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++V+ G +YW V ++ I+ A DG+ + + P GLA+D+ + I+W D
Sbjct: 4031 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD- 4089
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIF 430
E++ + + + SV ++S+ +G+ +HP R IF
Sbjct: 4090 ----FELSIIGSVLYDGSNSVVSVSSKQGL-LHPHRIDIF 4124
Score = 35.5 bits (78), Expect = 0.11
Identities = 21/81 (25%), Positives = 41/81 (50%)
Frame = +2
Query: 275 DWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSN 454
D S ++WTD K TI+ A ++ + + S ++I + RG+AV ++W
Sbjct: 1614 DASEERLYWTDIKTQTIKRAFINGTGLETVIS-RDIQSIRGLAVDWVSRNLYWISSEFDE 1672
Query: 455 PKIEWANMDGTERSVLLGSPD 517
+I A +DG+ ++ ++ D
Sbjct: 1673 TQINVARLDGSLKTSIIHGID 1693
Score = 35.1 bits (77), Expect = 0.15
Identities = 20/92 (21%), Positives = 44/92 (47%), Gaps = 1/92 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVS-NNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++VD +GK+++ D + ++R DG + +++ P LA+D + ++W D
Sbjct: 330 AIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDL 389
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAV 406
+ V + K R + + + + GI V
Sbjct: 390 YLDYVGVVDYQGKNRHTVIQGRQVRHLYGITV 421
Score = 33.5 bits (73), Expect = 0.46
Identities = 21/102 (20%), Positives = 47/102 (46%), Gaps = 1/102 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
+++D + +Y+ D V + I +GS ++ + +P+ +A+D A +F+TD
Sbjct: 288 MAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGN 347
Query: 317 LT-IEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
+ +E ++D R + P +A+ ++W D
Sbjct: 348 VAKVERCDMDGMNRTRIID-SKTEQPAALALDLVNKLVYWVD 388
Score = 33.5 bits (73), Expect = 0.46
Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 1/66 (1%)
Frame = +2
Query: 257 PEGLAIDWSARNIFWTD-SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFW 433
P +A++ ++WT IE A +D +R++L +N+ P G+AV +I+W
Sbjct: 4029 PYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQ-KNLQRPTGLAVDYFSERIYW 4087
Query: 434 TDWNRS 451
D+ S
Sbjct: 4088 ADFELS 4093
Score = 29.1 bits (62), Expect = 9.9
Identities = 14/59 (23%), Positives = 24/59 (40%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
V +S+D K+YW + I R DG E + + A+ + ++W D
Sbjct: 1736 VGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWAD 1794
Score = 29.1 bits (62), Expect = 9.9
Identities = 17/57 (29%), Positives = 30/57 (52%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
+++D + K+Y+ D I+R YDGS+ + +G + LA+ IFW+D
Sbjct: 2368 LTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAV--YDNYIFWSD 2422
Score = 29.1 bits (62), Expect = 9.9
Identities = 14/33 (42%), Positives = 18/33 (54%)
Frame = +2
Query: 122 QVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGS 220
Q ++VD FS +IYW D + I YDGS
Sbjct: 4071 QRPTGLAVDYFSERIYWADFELSIIGSVLYDGS 4103
>U33837-1|AAB41649.1| 4655|Homo sapiens gp330 precursor protein.
Length = 4655
Score = 105 bits (251), Expect = 1e-22
Identities = 51/127 (40%), Positives = 80/127 (62%), Gaps = 2/127 (1%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
V+V D SG+I+W D A +G++ ++ II E +AIDW RN++WTD
Sbjct: 1469 VAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDY 1528
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGK--IFWTDWNRSNPKIEWANMDG 484
TIEV+ +D R VL S +N++NPRG+A+ P+ + +FW+DW +P+IE A+MDG
Sbjct: 1529 ALETIEVSKIDGSHRTVLIS-KNLTNPRGLALDPRMNEHLLFWSDWGH-HPRIERASMDG 1586
Query: 485 TERSVLL 505
+ R+V++
Sbjct: 1587 SMRTVIV 1593
Score = 94.3 bits (224), Expect = 2e-19
Identities = 49/142 (34%), Positives = 76/142 (53%), Gaps = 2/142 (1%)
Frame = +2
Query: 86 REFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEG 265
R F + S VAV V+ +++W D V N + +G ++ LN + +PE
Sbjct: 412 RSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPEN 471
Query: 266 LAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
LA+DW I+ ++K I++ NLD R L + +N+ +PRGIAV P G +F++DW
Sbjct: 472 LAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLIT-ENLGHPRGIAVDPTVGYLFFSDWE 530
Query: 446 --RSNPKIEWANMDGTERSVLL 505
PK+E A MDG+ R L+
Sbjct: 531 SLSGEPKLERAFMDGSNRKDLV 552
Score = 90.6 bits (215), Expect = 3e-18
Identities = 53/154 (34%), Positives = 79/154 (51%)
Frame = +2
Query: 26 NFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRA 205
NFL+ S +I +PF S +E SG V + D I++ D+ + I +
Sbjct: 709 NFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQ 768
Query: 206 GYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNIS 385
DG+ E + + E LA DW ++N++WTDS +I V L K R+ + VQ ++
Sbjct: 769 KIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTV--VQYLN 826
Query: 386 NPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
NPR + VHP G +F+TDW R KI A DG+
Sbjct: 827 NPRSVVVHPFAGYLFFTDWFRP-AKIMRAWSDGS 859
Score = 89.4 bits (212), Expect = 7e-18
Identities = 40/86 (46%), Positives = 60/86 (69%)
Frame = +2
Query: 248 IISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKI 427
++ P+G+A+DW R+I+W+D K IEVA LD + RK L S ++ P IAV+P+ G +
Sbjct: 4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLIST-DLDQPAAIAVNPKLGLM 4199
Query: 428 FWTDWNRSNPKIEWANMDGTERSVLL 505
FWTDW + PKIE A M+G +R++L+
Sbjct: 4200 FWTDWGK-EPKIESAWMNGEDRNILV 4224
Score = 83.0 bits (196), Expect = 6e-16
Identities = 61/173 (35%), Positives = 93/173 (53%), Gaps = 10/173 (5%)
Frame = +2
Query: 17 PPGNFLVTSDGTSIYRVPFKYSPR-EFATPINSGISQVAVSVSVDCFSGKIYWGD----V 181
P +F+V S ++I + S E P+ +G + A+ V VD SG IYW D V
Sbjct: 2060 PYNSFIVVSMLSAIRGFSLELSDHSETMVPV-AGQGRNALHVDVDVSSGFIYWCDFSSSV 2118
Query: 182 VSNN-IKRAGYDGSEFEQFLNTGI--ISPEGLAIDWSARNIFWTDS--KKLTIEVANLDT 346
S+N I+R DGS + GI G+A+DW A N+++T++ + IEV ++T
Sbjct: 2119 ASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINT 2178
Query: 347 KVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
R+VL V + PR I V P+ +FW D+ + PKIE + +D T R+VL+
Sbjct: 2179 TYRRVLLKV-TVDMPRHIVVDPKNRYLFWADYGQ-RPKIERSFLDCTNRTVLV 2229
Score = 78.6 bits (185), Expect = 1e-14
Identities = 45/147 (30%), Positives = 77/147 (52%), Gaps = 7/147 (4%)
Frame = +2
Query: 92 FATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLA 271
F + I G+ V V++ D ++YW D I+R + + E +N + + E LA
Sbjct: 3218 FYSLILEGLDNV-VALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLA 3276
Query: 272 IDWSARNIFWTDSKKLTIEVANLDTKVRKVL----FSVQN---ISNPRGIAVHPQRGKIF 430
+DW +R ++W D++ + V++L+ R++L N NPRG+A+HPQ G ++
Sbjct: 3277 VDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLY 3336
Query: 431 WTDWNRSNPKIEWANMDGTERSVLLGS 511
W DW I MDGT +SV++ +
Sbjct: 3337 WADWGH-RAYIGRVGMDGTNKSVIIST 3362
Score = 66.9 bits (156), Expect = 4e-11
Identities = 46/137 (33%), Positives = 66/137 (48%), Gaps = 10/137 (7%)
Frame = +2
Query: 122 QVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPE-GLAIDWSARNIF 298
Q + V D IYW + I R DG+ F + ++ P LA+DW +RN++
Sbjct: 1778 QNGLDVEFDDAEQYIYWVEN-PGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLY 1836
Query: 299 WTDSKKLTIEVANL--DTKVRKVLF----SVQNISNPRGIAVHPQRGKIFWTDWNRSN-- 454
T+ + +IEV L D + RK L + + P GI V P RGK++W+D +
Sbjct: 1837 STNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGV 1896
Query: 455 -PKIEWANMDGTERSVL 502
KI ANMDGT L
Sbjct: 1897 PAKIASANMDGTSVKTL 1913
Score = 66.5 bits (155), Expect = 5e-11
Identities = 42/124 (33%), Positives = 66/124 (53%), Gaps = 1/124 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
SV V F+G +++ D I RA DGS +NT + P GLAIDW+A ++W D+
Sbjct: 830 SVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDA 889
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTE 490
IE + D R+ L ++ +++P G+A+ + +F+TDW R I DG E
Sbjct: 890 YFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEH--LFFTDW-RLGAIIRVRKADGGE 946
Query: 491 RSVL 502
+V+
Sbjct: 947 MTVI 950
Score = 62.5 bits (145), Expect = 9e-10
Identities = 44/165 (26%), Positives = 81/165 (49%), Gaps = 4/165 (2%)
Frame = +2
Query: 29 FLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAG 208
F +++ S++ P +SP F T IN + + +S+ D S +IY+ +++ + +
Sbjct: 2392 FALSNSLRSLHLDPENHSP-PFQT-IN--VERTVMSLDYDSVSDRIYFTQNLASGVGQIS 2447
Query: 209 Y----DGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQ 376
Y G + +GI + +G+A DW R I+++D I D R V +
Sbjct: 2448 YATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTV---IA 2504
Query: 377 NISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
+ PR I + P +G ++W DW+ ++ KIE A + G R ++ S
Sbjct: 2505 RVPKPRAIVLDPCQGYLYWADWD-THAKIERATLGGNFRVPIVNS 2548
Score = 52.8 bits (121), Expect = 7e-07
Identities = 35/120 (29%), Positives = 58/120 (48%), Gaps = 2/120 (1%)
Frame = +2
Query: 158 GKIYWGDVVSNN-IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
G +YW D I R G DG+ ++T + P G+ ID++ ++W D+ IE +
Sbjct: 3333 GYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYS 3392
Query: 335 NLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTERSVLLGS 511
+L+ R +V + + P A+ I+WTDWN +E N DG+ R L+ +
Sbjct: 3393 DLEGHHR---HTVYDGALPHPFAITIFEDTIYWTDWNTRT--VEKGNKYDGSNRQTLVNT 3447
Score = 50.4 bits (115), Expect = 4e-06
Identities = 31/109 (28%), Positives = 58/109 (53%), Gaps = 5/109 (4%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNN----IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWT 304
++VD G +++ D S + ++RA DGS + + T + P G+ +D ++ ++W
Sbjct: 515 IAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWV 574
Query: 305 DSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
DS+ IE D RK V+ I +P G+++ G++F+TDW +
Sbjct: 575 DSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLF--EGQVFFTDWTK 621
Score = 48.0 bits (109), Expect = 2e-05
Identities = 31/108 (28%), Positives = 52/108 (48%), Gaps = 5/108 (4%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDV-----VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
+ ++VD GK+YW D V I A DG+ + + E + +D + +
Sbjct: 1874 IGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKL 1933
Query: 296 FWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
+W + + IE N+D R +L V +S+P GIAVH +++TD
Sbjct: 1934 YWAVTGRGVIERGNVDGTDRMIL--VHQLSHPWGIAVHD--SFLYYTD 1977
Score = 46.0 bits (104), Expect = 8e-05
Identities = 28/103 (27%), Positives = 53/103 (51%), Gaps = 1/103 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ +D G +YW D ++ I+RA G+ +N+ ++ P GL +D+ ++W D+
Sbjct: 2511 AIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDA 2570
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
IE + L R+V+ V + G+ ++ Q I+WTD
Sbjct: 2571 SLQRIERSTLTGVDREVI--VNAAVHAFGLTLYGQ--YIYWTD 2609
Score = 41.9 bits (94), Expect = 0.001
Identities = 23/91 (25%), Positives = 44/91 (48%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
V++D S ++YW D + I+ YDG + + ++ G + P + +F+TD K
Sbjct: 562 VTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTK 621
Query: 317 LTIEVANLDTKVRKVLFSVQNISNPRGIAVH 409
+ + AN T+ ++ Q P G+ V+
Sbjct: 622 MAVLKANKFTETNPQVY-YQASLRPYGVTVY 651
Score = 41.5 bits (93), Expect = 0.002
Identities = 27/104 (25%), Positives = 46/104 (44%), Gaps = 1/104 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
+ VD + ++W D I+R+ D + ++ GI++P GLA+D S ++W D
Sbjct: 2195 IVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDS 2254
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
I ++ + +V+ P GI V I W D N
Sbjct: 2255 LDIIARIRINGENSEVIRYGSRYPTPYGITVF--ENSIIWVDRN 2296
Score = 37.9 bits (84), Expect = 0.021
Identities = 25/92 (27%), Positives = 45/92 (48%), Gaps = 5/92 (5%)
Frame = +2
Query: 245 GIISPEGLAIDWSARNIFWTDSKK-----LTIEVANLDTKVRKVLFSVQNISNPRGIAVH 409
G+ P G+ +D + ++W+D I AN+D K LF+ N+ + + +
Sbjct: 1869 GVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFT-GNLEHLECVTLD 1927
Query: 410 PQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ K++W R IE N+DGT+R +L+
Sbjct: 1928 IEEQKLYWAVTGRG--VIERGNVDGTDRMILV 1957
Score = 35.1 bits (77), Expect = 0.15
Identities = 24/103 (23%), Positives = 42/103 (40%)
Frame = +2
Query: 92 FATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLA 271
F PI + + +++D +YW D I+R+ G + E +N +
Sbjct: 2541 FRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAV---HAFG 2597
Query: 272 IDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGI 400
+ + I+WTD I AN ++ + +S PRGI
Sbjct: 2598 LTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGI 2640
Score = 34.7 bits (76), Expect = 0.20
Identities = 31/117 (26%), Positives = 57/117 (48%), Gaps = 3/117 (2%)
Frame = +2
Query: 164 IYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANL 340
++W D + I+RA DGS + I P GL ID+ R +++ DS ++ +
Sbjct: 1568 LFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDY 1627
Query: 341 DTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTERSVLL 505
+ R+ V+ S I +P + + ++WTD R+ ++ AN G +SV++
Sbjct: 1628 NGHHRRQVIASDLIIRHPYALTLF--EDSVYWTD--RATRRVMRANKWHGGNQSVVM 1680
Score = 30.3 bits (65), Expect = 4.3
Identities = 18/54 (33%), Positives = 29/54 (53%)
Frame = +2
Query: 350 VRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
V++V ++ + P GIAV I+W+D N +IE A +DG R L+ +
Sbjct: 4131 VQEVDLKLKYVMQPDGIAVDWVGRHIYWSD--VKNKRIEVAKLDGRYRKWLIST 4182
>AY265358-1|AAP88586.1| 4655|Homo sapiens glycoprotein receptor
gp330/megalin precursor protein.
Length = 4655
Score = 105 bits (251), Expect = 1e-22
Identities = 51/127 (40%), Positives = 80/127 (62%), Gaps = 2/127 (1%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
V+V D SG+I+W D A +G++ ++ II E +AIDW RN++WTD
Sbjct: 1469 VAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDY 1528
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGK--IFWTDWNRSNPKIEWANMDG 484
TIEV+ +D R VL S +N++NPRG+A+ P+ + +FW+DW +P+IE A+MDG
Sbjct: 1529 ALETIEVSKIDGSHRTVLIS-KNLTNPRGLALDPRMNEHLLFWSDWGH-HPRIERASMDG 1586
Query: 485 TERSVLL 505
+ R+V++
Sbjct: 1587 SMRTVIV 1593
Score = 94.3 bits (224), Expect = 2e-19
Identities = 49/142 (34%), Positives = 76/142 (53%), Gaps = 2/142 (1%)
Frame = +2
Query: 86 REFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEG 265
R F + S VAV V+ +++W D V N + +G ++ LN + +PE
Sbjct: 412 RSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPEN 471
Query: 266 LAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
LA+DW I+ ++K I++ NLD R L + +N+ +PRGIAV P G +F++DW
Sbjct: 472 LAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLIT-ENLGHPRGIAVDPTVGYLFFSDWE 530
Query: 446 --RSNPKIEWANMDGTERSVLL 505
PK+E A MDG+ R L+
Sbjct: 531 SLSGEPKLERAFMDGSNRKDLV 552
Score = 90.6 bits (215), Expect = 3e-18
Identities = 53/154 (34%), Positives = 79/154 (51%)
Frame = +2
Query: 26 NFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRA 205
NFL+ S +I +PF S +E SG V + D I++ D+ + I +
Sbjct: 709 NFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQ 768
Query: 206 GYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNIS 385
DG+ E + + E LA DW ++N++WTDS +I V L K R+ + VQ ++
Sbjct: 769 KIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTV--VQYLN 826
Query: 386 NPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
NPR + VHP G +F+TDW R KI A DG+
Sbjct: 827 NPRSVVVHPFAGYLFFTDWFRP-AKIMRAWSDGS 859
Score = 88.6 bits (210), Expect = 1e-17
Identities = 39/86 (45%), Positives = 60/86 (69%)
Frame = +2
Query: 248 IISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKI 427
++ P+G+A+DW R+I+W+D K IEVA LD + RK L S ++ P IAV+P+ G +
Sbjct: 4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLIST-DLDQPAAIAVNPKLGLM 4199
Query: 428 FWTDWNRSNPKIEWANMDGTERSVLL 505
FWTDW + PK+E A M+G +R++L+
Sbjct: 4200 FWTDWGK-EPKLESAWMNGEDRNILV 4224
Score = 83.0 bits (196), Expect = 6e-16
Identities = 61/173 (35%), Positives = 93/173 (53%), Gaps = 10/173 (5%)
Frame = +2
Query: 17 PPGNFLVTSDGTSIYRVPFKYSPR-EFATPINSGISQVAVSVSVDCFSGKIYWGD----V 181
P +F+V S ++I + S E P+ +G + A+ V VD SG IYW D V
Sbjct: 2060 PYNSFIVVSMLSAIRGFSLELSDHSETMVPV-AGQGRNALHVDVDVSSGFIYWCDFSSSV 2118
Query: 182 VSNN-IKRAGYDGSEFEQFLNTGI--ISPEGLAIDWSARNIFWTDS--KKLTIEVANLDT 346
S+N I+R DGS + GI G+A+DW A N+++T++ + IEV ++T
Sbjct: 2119 ASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINT 2178
Query: 347 KVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
R+VL V + PR I V P+ +FW D+ + PKIE + +D T R+VL+
Sbjct: 2179 TYRRVLLKV-TVDMPRHIVVDPKNRYLFWADYGQ-RPKIERSFLDCTNRTVLV 2229
Score = 78.6 bits (185), Expect = 1e-14
Identities = 45/147 (30%), Positives = 77/147 (52%), Gaps = 7/147 (4%)
Frame = +2
Query: 92 FATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLA 271
F + I G+ V V++ D ++YW D I+R + + E +N + + E LA
Sbjct: 3218 FYSLILEGLDNV-VALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLA 3276
Query: 272 IDWSARNIFWTDSKKLTIEVANLDTKVRKVL----FSVQN---ISNPRGIAVHPQRGKIF 430
+DW +R ++W D++ + V++L+ R++L N NPRG+A+HPQ G ++
Sbjct: 3277 VDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLY 3336
Query: 431 WTDWNRSNPKIEWANMDGTERSVLLGS 511
W DW I MDGT +SV++ +
Sbjct: 3337 WADWGH-RAYIGRVGMDGTNKSVIIST 3362
Score = 66.9 bits (156), Expect = 4e-11
Identities = 46/137 (33%), Positives = 66/137 (48%), Gaps = 10/137 (7%)
Frame = +2
Query: 122 QVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPE-GLAIDWSARNIF 298
Q + V D IYW + I R DG+ F + ++ P LA+DW +RN++
Sbjct: 1778 QNGLDVEFDDAEQYIYWVEN-PGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLY 1836
Query: 299 WTDSKKLTIEVANL--DTKVRKVLF----SVQNISNPRGIAVHPQRGKIFWTDWNRSN-- 454
T+ + +IEV L D + RK L + + P GI V P RGK++W+D +
Sbjct: 1837 STNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGV 1896
Query: 455 -PKIEWANMDGTERSVL 502
KI ANMDGT L
Sbjct: 1897 PAKIASANMDGTSVKTL 1913
Score = 66.5 bits (155), Expect = 5e-11
Identities = 42/124 (33%), Positives = 66/124 (53%), Gaps = 1/124 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
SV V F+G +++ D I RA DGS +NT + P GLAIDW+A ++W D+
Sbjct: 830 SVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDA 889
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTE 490
IE + D R+ L ++ +++P G+A+ + +F+TDW R I DG E
Sbjct: 890 YFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEH--LFFTDW-RLGAIIRVRKADGGE 946
Query: 491 RSVL 502
+V+
Sbjct: 947 MTVI 950
Score = 62.5 bits (145), Expect = 9e-10
Identities = 44/165 (26%), Positives = 81/165 (49%), Gaps = 4/165 (2%)
Frame = +2
Query: 29 FLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAG 208
F +++ S++ P +SP F T IN + + +S+ D S +IY+ +++ + +
Sbjct: 2392 FALSNSLRSLHLDPENHSP-PFQT-IN--VERTVMSLDYDSVSDRIYFTQNLASGVGQIS 2447
Query: 209 Y----DGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQ 376
Y G + +GI + +G+A DW R I+++D I D R V +
Sbjct: 2448 YATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTV---IA 2504
Query: 377 NISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
+ PR I + P +G ++W DW+ ++ KIE A + G R ++ S
Sbjct: 2505 RVPKPRAIVLDPCQGYLYWADWD-THAKIERATLGGNFRVPIVNS 2548
Score = 52.8 bits (121), Expect = 7e-07
Identities = 35/120 (29%), Positives = 58/120 (48%), Gaps = 2/120 (1%)
Frame = +2
Query: 158 GKIYWGDVVSNN-IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
G +YW D I R G DG+ ++T + P G+ ID++ ++W D+ IE +
Sbjct: 3333 GYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYS 3392
Query: 335 NLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTERSVLLGS 511
+L+ R +V + + P A+ I+WTDWN +E N DG+ R L+ +
Sbjct: 3393 DLEGHHR---HTVYDGALPHPFAITIFEDTIYWTDWNTRT--VEKGNKYDGSNRQTLVNT 3447
Score = 50.4 bits (115), Expect = 4e-06
Identities = 31/109 (28%), Positives = 58/109 (53%), Gaps = 5/109 (4%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNN----IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWT 304
++VD G +++ D S + ++RA DGS + + T + P G+ +D ++ ++W
Sbjct: 515 IAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWV 574
Query: 305 DSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
DS+ IE D RK V+ I +P G+++ G++F+TDW +
Sbjct: 575 DSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLF--EGQVFFTDWTK 621
Score = 48.0 bits (109), Expect = 2e-05
Identities = 31/108 (28%), Positives = 52/108 (48%), Gaps = 5/108 (4%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDV-----VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
+ ++VD GK+YW D V I A DG+ + + E + +D + +
Sbjct: 1874 IGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKL 1933
Query: 296 FWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
+W + + IE N+D R +L V +S+P GIAVH +++TD
Sbjct: 1934 YWAVTGRGVIERGNVDGTDRMIL--VHQLSHPWGIAVHD--SFLYYTD 1977
Score = 46.0 bits (104), Expect = 8e-05
Identities = 28/103 (27%), Positives = 53/103 (51%), Gaps = 1/103 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ +D G +YW D ++ I+RA G+ +N+ ++ P GL +D+ ++W D+
Sbjct: 2511 AIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDA 2570
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
IE + L R+V+ V + G+ ++ Q I+WTD
Sbjct: 2571 SLQRIERSTLTGVDREVI--VNAAVHAFGLTLYGQ--YIYWTD 2609
Score = 41.9 bits (94), Expect = 0.001
Identities = 23/91 (25%), Positives = 44/91 (48%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
V++D S ++YW D + I+ YDG + + ++ G + P + +F+TD K
Sbjct: 562 VTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTK 621
Query: 317 LTIEVANLDTKVRKVLFSVQNISNPRGIAVH 409
+ + AN T+ ++ Q P G+ V+
Sbjct: 622 MAVLKANKFTETNPQVY-YQASLRPYGVTVY 651
Score = 41.5 bits (93), Expect = 0.002
Identities = 27/104 (25%), Positives = 46/104 (44%), Gaps = 1/104 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
+ VD + ++W D I+R+ D + ++ GI++P GLA+D S ++W D
Sbjct: 2195 IVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDS 2254
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
I ++ + +V+ P GI V I W D N
Sbjct: 2255 LDIIARIRINGENSEVIRYGSRYPTPYGITVF--ENSIIWVDRN 2296
Score = 37.9 bits (84), Expect = 0.021
Identities = 25/92 (27%), Positives = 45/92 (48%), Gaps = 5/92 (5%)
Frame = +2
Query: 245 GIISPEGLAIDWSARNIFWTDSKK-----LTIEVANLDTKVRKVLFSVQNISNPRGIAVH 409
G+ P G+ +D + ++W+D I AN+D K LF+ N+ + + +
Sbjct: 1869 GVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFT-GNLEHLECVTLD 1927
Query: 410 PQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ K++W R IE N+DGT+R +L+
Sbjct: 1928 IEEQKLYWAVTGRG--VIERGNVDGTDRMILV 1957
Score = 35.1 bits (77), Expect = 0.15
Identities = 24/103 (23%), Positives = 42/103 (40%)
Frame = +2
Query: 92 FATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLA 271
F PI + + +++D +YW D I+R+ G + E +N +
Sbjct: 2541 FRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAV---HAFG 2597
Query: 272 IDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGI 400
+ + I+WTD I AN ++ + +S PRGI
Sbjct: 2598 LTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGI 2640
Score = 34.7 bits (76), Expect = 0.20
Identities = 31/117 (26%), Positives = 57/117 (48%), Gaps = 3/117 (2%)
Frame = +2
Query: 164 IYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANL 340
++W D + I+RA DGS + I P GL ID+ R +++ DS ++ +
Sbjct: 1568 LFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDY 1627
Query: 341 DTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTERSVLL 505
+ R+ V+ S I +P + + ++WTD R+ ++ AN G +SV++
Sbjct: 1628 NGHHRRQVIASDLIIRHPYALTLF--EDSVYWTD--RATRRVMRANKWHGGNQSVVM 1680
Score = 30.3 bits (65), Expect = 4.3
Identities = 18/54 (33%), Positives = 29/54 (53%)
Frame = +2
Query: 350 VRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
V++V ++ + P GIAV I+W+D N +IE A +DG R L+ +
Sbjct: 4131 VQEVDLKLKYVMQPDGIAVDWVGRHIYWSD--VKNKRIEVAKLDGRYRKWLIST 4182
>AY265357-1|AAP88585.1| 4655|Homo sapiens glycoprotein receptor
gp330/megalin precursor protein.
Length = 4655
Score = 105 bits (251), Expect = 1e-22
Identities = 51/127 (40%), Positives = 80/127 (62%), Gaps = 2/127 (1%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
V+V D SG+I+W D A +G++ ++ II E +AIDW RN++WTD
Sbjct: 1469 VAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDY 1528
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGK--IFWTDWNRSNPKIEWANMDG 484
TIEV+ +D R VL S +N++NPRG+A+ P+ + +FW+DW +P+IE A+MDG
Sbjct: 1529 ALETIEVSKIDGSHRTVLIS-KNLTNPRGLALDPRMNEHLLFWSDWGH-HPRIERASMDG 1586
Query: 485 TERSVLL 505
+ R+V++
Sbjct: 1587 SMRTVIV 1593
Score = 94.3 bits (224), Expect = 2e-19
Identities = 49/142 (34%), Positives = 76/142 (53%), Gaps = 2/142 (1%)
Frame = +2
Query: 86 REFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEG 265
R F + S VAV V+ +++W D V N + +G ++ LN + +PE
Sbjct: 412 RSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPEN 471
Query: 266 LAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
LA+DW I+ ++K I++ NLD R L + +N+ +PRGIAV P G +F++DW
Sbjct: 472 LAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLIT-ENLGHPRGIAVDPTVGYLFFSDWE 530
Query: 446 --RSNPKIEWANMDGTERSVLL 505
PK+E A MDG+ R L+
Sbjct: 531 SLSGEPKLERAFMDGSNRKDLV 552
Score = 90.6 bits (215), Expect = 3e-18
Identities = 53/154 (34%), Positives = 79/154 (51%)
Frame = +2
Query: 26 NFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRA 205
NFL+ S +I +PF S +E SG V + D I++ D+ + I +
Sbjct: 709 NFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQ 768
Query: 206 GYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNIS 385
DG+ E + + E LA DW ++N++WTDS +I V L K R+ + VQ ++
Sbjct: 769 KIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTV--VQYLN 826
Query: 386 NPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
NPR + VHP G +F+TDW R KI A DG+
Sbjct: 827 NPRSVVVHPFAGYLFFTDWFRP-AKIMRAWSDGS 859
Score = 87.4 bits (207), Expect = 3e-17
Identities = 39/86 (45%), Positives = 59/86 (68%)
Frame = +2
Query: 248 IISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKI 427
++ P+G+A+DW R+I+W+D K IEVA LD + RK L S ++ P IAV+P+ G +
Sbjct: 4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLIST-DLDQPAAIAVNPKLGLM 4199
Query: 428 FWTDWNRSNPKIEWANMDGTERSVLL 505
FWTDW + PK E A M+G +R++L+
Sbjct: 4200 FWTDWGK-EPKXESAWMNGEDRNILV 4224
Score = 83.0 bits (196), Expect = 6e-16
Identities = 61/173 (35%), Positives = 93/173 (53%), Gaps = 10/173 (5%)
Frame = +2
Query: 17 PPGNFLVTSDGTSIYRVPFKYSPR-EFATPINSGISQVAVSVSVDCFSGKIYWGD----V 181
P +F+V S ++I + S E P+ +G + A+ V VD SG IYW D V
Sbjct: 2060 PYNSFIVVSMLSAIRGFSLELSDHSETMVPV-AGQGRNALHVDVDVSSGFIYWCDFSSSV 2118
Query: 182 VSNN-IKRAGYDGSEFEQFLNTGI--ISPEGLAIDWSARNIFWTDS--KKLTIEVANLDT 346
S+N I+R DGS + GI G+A+DW A N+++T++ + IEV ++T
Sbjct: 2119 ASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINT 2178
Query: 347 KVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
R+VL V + PR I V P+ +FW D+ + PKIE + +D T R+VL+
Sbjct: 2179 TYRRVLLKV-TVDMPRHIVVDPKNRYLFWADYGQ-RPKIERSFLDCTNRTVLV 2229
Score = 78.6 bits (185), Expect = 1e-14
Identities = 45/147 (30%), Positives = 77/147 (52%), Gaps = 7/147 (4%)
Frame = +2
Query: 92 FATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLA 271
F + I G+ V V++ D ++YW D I+R + + E +N + + E LA
Sbjct: 3218 FYSLILEGLDNV-VALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLA 3276
Query: 272 IDWSARNIFWTDSKKLTIEVANLDTKVRKVL----FSVQN---ISNPRGIAVHPQRGKIF 430
+DW +R ++W D++ + V++L+ R++L N NPRG+A+HPQ G ++
Sbjct: 3277 VDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLY 3336
Query: 431 WTDWNRSNPKIEWANMDGTERSVLLGS 511
W DW I MDGT +SV++ +
Sbjct: 3337 WADWGH-RAYIGRVGMDGTNKSVIIST 3362
Score = 66.9 bits (156), Expect = 4e-11
Identities = 46/137 (33%), Positives = 66/137 (48%), Gaps = 10/137 (7%)
Frame = +2
Query: 122 QVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPE-GLAIDWSARNIF 298
Q + V D IYW + I R DG+ F + ++ P LA+DW +RN++
Sbjct: 1778 QNGLDVEFDDAEQYIYWVEN-PGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLY 1836
Query: 299 WTDSKKLTIEVANL--DTKVRKVLF----SVQNISNPRGIAVHPQRGKIFWTDWNRSN-- 454
T+ + +IEV L D + RK L + + P GI V P RGK++W+D +
Sbjct: 1837 STNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGV 1896
Query: 455 -PKIEWANMDGTERSVL 502
KI ANMDGT L
Sbjct: 1897 PAKIASANMDGTSVKTL 1913
Score = 66.5 bits (155), Expect = 5e-11
Identities = 42/124 (33%), Positives = 66/124 (53%), Gaps = 1/124 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
SV V F+G +++ D I RA DGS +NT + P GLAIDW+A ++W D+
Sbjct: 830 SVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDA 889
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTE 490
IE + D R+ L ++ +++P G+A+ + +F+TDW R I DG E
Sbjct: 890 YFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEH--LFFTDW-RLGAIIRVRKADGGE 946
Query: 491 RSVL 502
+V+
Sbjct: 947 MTVI 950
Score = 62.5 bits (145), Expect = 9e-10
Identities = 44/165 (26%), Positives = 81/165 (49%), Gaps = 4/165 (2%)
Frame = +2
Query: 29 FLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAG 208
F +++ S++ P +SP F T IN + + +S+ D S +IY+ +++ + +
Sbjct: 2392 FALSNSLRSLHLDPENHSP-PFQT-IN--VERTVMSLDYDSVSDRIYFTQNLASGVGQIS 2447
Query: 209 Y----DGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQ 376
Y G + +GI + +G+A DW R I+++D I D R V +
Sbjct: 2448 YATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTV---IA 2504
Query: 377 NISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
+ PR I + P +G ++W DW+ ++ KIE A + G R ++ S
Sbjct: 2505 RVPKPRAIVLDPCQGYLYWADWD-THAKIERATLGGNFRVPIVNS 2548
Score = 52.8 bits (121), Expect = 7e-07
Identities = 35/120 (29%), Positives = 58/120 (48%), Gaps = 2/120 (1%)
Frame = +2
Query: 158 GKIYWGDVVSNN-IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
G +YW D I R G DG+ ++T + P G+ ID++ ++W D+ IE +
Sbjct: 3333 GYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYS 3392
Query: 335 NLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTERSVLLGS 511
+L+ R +V + + P A+ I+WTDWN +E N DG+ R L+ +
Sbjct: 3393 DLEGHHR---HTVYDGALPHPFAITIFEDTIYWTDWNTRT--VEKGNKYDGSNRQTLVNT 3447
Score = 50.4 bits (115), Expect = 4e-06
Identities = 31/109 (28%), Positives = 58/109 (53%), Gaps = 5/109 (4%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNN----IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWT 304
++VD G +++ D S + ++RA DGS + + T + P G+ +D ++ ++W
Sbjct: 515 IAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWV 574
Query: 305 DSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
DS+ IE D RK V+ I +P G+++ G++F+TDW +
Sbjct: 575 DSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLF--EGQVFFTDWTK 621
Score = 48.0 bits (109), Expect = 2e-05
Identities = 31/108 (28%), Positives = 52/108 (48%), Gaps = 5/108 (4%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDV-----VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
+ ++VD GK+YW D V I A DG+ + + E + +D + +
Sbjct: 1874 IGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKL 1933
Query: 296 FWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
+W + + IE N+D R +L V +S+P GIAVH +++TD
Sbjct: 1934 YWAVTGRGVIERGNVDGTDRMIL--VHQLSHPWGIAVHD--SFLYYTD 1977
Score = 46.0 bits (104), Expect = 8e-05
Identities = 28/103 (27%), Positives = 53/103 (51%), Gaps = 1/103 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ +D G +YW D ++ I+RA G+ +N+ ++ P GL +D+ ++W D+
Sbjct: 2511 AIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDA 2570
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
IE + L R+V+ V + G+ ++ Q I+WTD
Sbjct: 2571 SLQRIERSTLTGVDREVI--VNAAVHAFGLTLYGQ--YIYWTD 2609
Score = 41.9 bits (94), Expect = 0.001
Identities = 23/91 (25%), Positives = 44/91 (48%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
V++D S ++YW D + I+ YDG + + ++ G + P + +F+TD K
Sbjct: 562 VTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTK 621
Query: 317 LTIEVANLDTKVRKVLFSVQNISNPRGIAVH 409
+ + AN T+ ++ Q P G+ V+
Sbjct: 622 MAVLKANKFTETNPQVY-YQASLRPYGVTVY 651
Score = 41.5 bits (93), Expect = 0.002
Identities = 27/104 (25%), Positives = 46/104 (44%), Gaps = 1/104 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
+ VD + ++W D I+R+ D + ++ GI++P GLA+D S ++W D
Sbjct: 2195 IVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDS 2254
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
I ++ + +V+ P GI V I W D N
Sbjct: 2255 LDIIARIRINGENSEVIRYGSRYPTPYGITVF--ENSIIWVDRN 2296
Score = 37.9 bits (84), Expect = 0.021
Identities = 25/92 (27%), Positives = 45/92 (48%), Gaps = 5/92 (5%)
Frame = +2
Query: 245 GIISPEGLAIDWSARNIFWTDSKK-----LTIEVANLDTKVRKVLFSVQNISNPRGIAVH 409
G+ P G+ +D + ++W+D I AN+D K LF+ N+ + + +
Sbjct: 1869 GVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFT-GNLEHLECVTLD 1927
Query: 410 PQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ K++W R IE N+DGT+R +L+
Sbjct: 1928 IEEQKLYWAVTGRG--VIERGNVDGTDRMILV 1957
Score = 35.1 bits (77), Expect = 0.15
Identities = 24/103 (23%), Positives = 42/103 (40%)
Frame = +2
Query: 92 FATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLA 271
F PI + + +++D +YW D I+R+ G + E +N +
Sbjct: 2541 FRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAV---HAFG 2597
Query: 272 IDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGI 400
+ + I+WTD I AN ++ + +S PRGI
Sbjct: 2598 LTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGI 2640
Score = 34.7 bits (76), Expect = 0.20
Identities = 31/117 (26%), Positives = 57/117 (48%), Gaps = 3/117 (2%)
Frame = +2
Query: 164 IYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANL 340
++W D + I+RA DGS + I P GL ID+ R +++ DS ++ +
Sbjct: 1568 LFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDY 1627
Query: 341 DTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTERSVLL 505
+ R+ V+ S I +P + + ++WTD R+ ++ AN G +SV++
Sbjct: 1628 NGHHRRQVIASDLIIRHPYALTLF--EDSVYWTD--RATRRVMRANKWHGGNQSVVM 1680
Score = 30.3 bits (65), Expect = 4.3
Identities = 18/54 (33%), Positives = 29/54 (53%)
Frame = +2
Query: 350 VRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
V++V ++ + P GIAV I+W+D N +IE A +DG R L+ +
Sbjct: 4131 VQEVDLKLKYVMQPDGIAVDWVGRHIYWSD--VKNKRIEVAKLDGRYRKWLIST 4182
>AC007556-2|AAX88965.1| 3881|Homo sapiens unknown protein.
Length = 3881
Score = 105 bits (251), Expect = 1e-22
Identities = 51/127 (40%), Positives = 80/127 (62%), Gaps = 2/127 (1%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
V+V D SG+I+W D A +G++ ++ II E +AIDW RN++WTD
Sbjct: 695 VAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDY 754
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGK--IFWTDWNRSNPKIEWANMDG 484
TIEV+ +D R VL S +N++NPRG+A+ P+ + +FW+DW +P+IE A+MDG
Sbjct: 755 ALETIEVSKIDGSHRTVLIS-KNLTNPRGLALDPRMNEHLLFWSDWGH-HPRIERASMDG 812
Query: 485 TERSVLL 505
+ R+V++
Sbjct: 813 SMRTVIV 819
Score = 89.4 bits (212), Expect = 7e-18
Identities = 40/86 (46%), Positives = 60/86 (69%)
Frame = +2
Query: 248 IISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKI 427
++ P+G+A+DW R+I+W+D K IEVA LD + RK L S ++ P IAV+P+ G +
Sbjct: 3367 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLIST-DLDQPAAIAVNPKLGLM 3425
Query: 428 FWTDWNRSNPKIEWANMDGTERSVLL 505
FWTDW + PKIE A M+G +R++L+
Sbjct: 3426 FWTDWGK-EPKIESAWMNGEDRNILV 3450
Score = 83.0 bits (196), Expect = 6e-16
Identities = 61/173 (35%), Positives = 93/173 (53%), Gaps = 10/173 (5%)
Frame = +2
Query: 17 PPGNFLVTSDGTSIYRVPFKYSPR-EFATPINSGISQVAVSVSVDCFSGKIYWGD----V 181
P +F+V S ++I + S E P+ +G + A+ V VD SG IYW D V
Sbjct: 1286 PYNSFIVVSMLSAIRGFSLELSDHSETMVPV-AGQGRNALHVDVDVSSGFIYWCDFSSSV 1344
Query: 182 VSNN-IKRAGYDGSEFEQFLNTGI--ISPEGLAIDWSARNIFWTDS--KKLTIEVANLDT 346
S+N I+R DGS + GI G+A+DW A N+++T++ + IEV ++T
Sbjct: 1345 ASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINT 1404
Query: 347 KVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
R+VL V + PR I V P+ +FW D+ + PKIE + +D T R+VL+
Sbjct: 1405 TYRRVLLKV-TVDMPRHIVVDPKNRYLFWADYGQ-RPKIERSFLDCTNRTVLV 1455
Score = 78.6 bits (185), Expect = 1e-14
Identities = 45/147 (30%), Positives = 77/147 (52%), Gaps = 7/147 (4%)
Frame = +2
Query: 92 FATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLA 271
F + I G+ V V++ D ++YW D I+R + + E +N + + E LA
Sbjct: 2444 FYSLILEGLDNV-VALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLA 2502
Query: 272 IDWSARNIFWTDSKKLTIEVANLDTKVRKVL----FSVQN---ISNPRGIAVHPQRGKIF 430
+DW +R ++W D++ + V++L+ R++L N NPRG+A+HPQ G ++
Sbjct: 2503 VDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLY 2562
Query: 431 WTDWNRSNPKIEWANMDGTERSVLLGS 511
W DW I MDGT +SV++ +
Sbjct: 2563 WADWGH-RAYIGRVGMDGTNKSVIIST 2588
Score = 67.7 bits (158), Expect = 2e-11
Identities = 34/76 (44%), Positives = 47/76 (61%)
Frame = +2
Query: 260 EGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
E LA DW ++N++WTDS +I V L K R+ + VQ ++NPR + VHP G +F+TD
Sbjct: 13 ESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTV--VQYLNNPRSVVVHPFAGYLFFTD 70
Query: 440 WNRSNPKIEWANMDGT 487
W R KI A DG+
Sbjct: 71 WFRP-AKIMRAWSDGS 85
Score = 66.9 bits (156), Expect = 4e-11
Identities = 46/137 (33%), Positives = 66/137 (48%), Gaps = 10/137 (7%)
Frame = +2
Query: 122 QVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPE-GLAIDWSARNIF 298
Q + V D IYW + I R DG+ F + ++ P LA+DW +RN++
Sbjct: 1004 QNGLDVEFDDAEQYIYWVEN-PGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLY 1062
Query: 299 WTDSKKLTIEVANL--DTKVRKVLF----SVQNISNPRGIAVHPQRGKIFWTDWNRSN-- 454
T+ + +IEV L D + RK L + + P GI V P RGK++W+D +
Sbjct: 1063 STNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGV 1122
Query: 455 -PKIEWANMDGTERSVL 502
KI ANMDGT L
Sbjct: 1123 PAKIASANMDGTSVKTL 1139
Score = 66.5 bits (155), Expect = 5e-11
Identities = 42/124 (33%), Positives = 66/124 (53%), Gaps = 1/124 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
SV V F+G +++ D I RA DGS +NT + P GLAIDW+A ++W D+
Sbjct: 56 SVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDA 115
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTE 490
IE + D R+ L ++ +++P G+A+ + +F+TDW R I DG E
Sbjct: 116 YFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEH--LFFTDW-RLGAIIRVRKADGGE 172
Query: 491 RSVL 502
+V+
Sbjct: 173 MTVI 176
Score = 62.5 bits (145), Expect = 9e-10
Identities = 44/165 (26%), Positives = 81/165 (49%), Gaps = 4/165 (2%)
Frame = +2
Query: 29 FLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAG 208
F +++ S++ P +SP F T IN + + +S+ D S +IY+ +++ + +
Sbjct: 1618 FALSNSLRSLHLDPENHSP-PFQT-IN--VERTVMSLDYDSVSDRIYFTQNLASGVGQIS 1673
Query: 209 Y----DGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQ 376
Y G + +GI + +G+A DW R I+++D I D R V +
Sbjct: 1674 YATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTV---IA 1730
Query: 377 NISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
+ PR I + P +G ++W DW+ ++ KIE A + G R ++ S
Sbjct: 1731 RVPKPRAIVLDPCQGYLYWADWD-THAKIERATLGGNFRVPIVNS 1774
Score = 52.8 bits (121), Expect = 7e-07
Identities = 35/120 (29%), Positives = 58/120 (48%), Gaps = 2/120 (1%)
Frame = +2
Query: 158 GKIYWGDVVSNN-IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
G +YW D I R G DG+ ++T + P G+ ID++ ++W D+ IE +
Sbjct: 2559 GYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYS 2618
Query: 335 NLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTERSVLLGS 511
+L+ R +V + + P A+ I+WTDWN +E N DG+ R L+ +
Sbjct: 2619 DLEGHHR---HTVYDGALPHPFAITIFEDTIYWTDWNTRT--VEKGNKYDGSNRQTLVNT 2673
Score = 48.0 bits (109), Expect = 2e-05
Identities = 31/108 (28%), Positives = 52/108 (48%), Gaps = 5/108 (4%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDV-----VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
+ ++VD GK+YW D V I A DG+ + + E + +D + +
Sbjct: 1100 IGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKL 1159
Query: 296 FWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
+W + + IE N+D R +L V +S+P GIAVH +++TD
Sbjct: 1160 YWAVTGRGVIERGNVDGTDRMIL--VHQLSHPWGIAVHD--SFLYYTD 1203
Score = 46.0 bits (104), Expect = 8e-05
Identities = 28/103 (27%), Positives = 53/103 (51%), Gaps = 1/103 (0%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ +D G +YW D ++ I+RA G+ +N+ ++ P GL +D+ ++W D+
Sbjct: 1737 AIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDA 1796
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
IE + L R+V+ V + G+ ++ Q I+WTD
Sbjct: 1797 SLQRIERSTLTGVDREVI--VNAAVHAFGLTLYGQ--YIYWTD 1835
Score = 41.5 bits (93), Expect = 0.002
Identities = 27/104 (25%), Positives = 46/104 (44%), Gaps = 1/104 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
+ VD + ++W D I+R+ D + ++ GI++P GLA+D S ++W D
Sbjct: 1421 IVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDS 1480
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
I ++ + +V+ P GI V I W D N
Sbjct: 1481 LDIIARIRINGENSEVIRYGSRYPTPYGITVF--ENSIIWVDRN 1522
Score = 37.9 bits (84), Expect = 0.021
Identities = 25/92 (27%), Positives = 45/92 (48%), Gaps = 5/92 (5%)
Frame = +2
Query: 245 GIISPEGLAIDWSARNIFWTDSKK-----LTIEVANLDTKVRKVLFSVQNISNPRGIAVH 409
G+ P G+ +D + ++W+D I AN+D K LF+ N+ + + +
Sbjct: 1095 GVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFT-GNLEHLECVTLD 1153
Query: 410 PQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ K++W R IE N+DGT+R +L+
Sbjct: 1154 IEEQKLYWAVTGRG--VIERGNVDGTDRMILV 1183
Score = 35.1 bits (77), Expect = 0.15
Identities = 24/103 (23%), Positives = 42/103 (40%)
Frame = +2
Query: 92 FATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLA 271
F PI + + +++D +YW D I+R+ G + E +N +
Sbjct: 1767 FRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAV---HAFG 1823
Query: 272 IDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGI 400
+ + I+WTD I AN ++ + +S PRGI
Sbjct: 1824 LTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGI 1866
Score = 34.7 bits (76), Expect = 0.20
Identities = 31/117 (26%), Positives = 57/117 (48%), Gaps = 3/117 (2%)
Frame = +2
Query: 164 IYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANL 340
++W D + I+RA DGS + I P GL ID+ R +++ DS ++ +
Sbjct: 794 LFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDY 853
Query: 341 DTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTERSVLL 505
+ R+ V+ S I +P + + ++WTD R+ ++ AN G +SV++
Sbjct: 854 NGHHRRQVIASDLIIRHPYALTLF--EDSVYWTD--RATRRVMRANKWHGGNQSVVM 906
Score = 30.3 bits (65), Expect = 4.3
Identities = 18/54 (33%), Positives = 29/54 (53%)
Frame = +2
Query: 350 VRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
V++V ++ + P GIAV I+W+D N +IE A +DG R L+ +
Sbjct: 3357 VQEVDLKLKYVMQPDGIAVDWVGRHIYWSD--VKNKRIEVAKLDGRYRKWLIST 3408
>X04571-1|CAA28240.1| 1207|Homo sapiens protein ( Human mRNA for
kidney epidermal growth factor (EGF) precursor. ).
Length = 1207
Score = 103 bits (247), Expect = 4e-22
Identities = 60/167 (35%), Positives = 94/167 (56%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSN 190
PQP FL+ ++ I + F + ++ T ++ + V ++ D KIY+
Sbjct: 481 PQP---FLLFANSQDIRHMHFDGT--DYGTLLSQQMGMV-YALDHDPVENKIYFAHTALK 534
Query: 191 NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFS 370
I+RA DGS+ E+ + G+ PEGLA+DW R +WTD K I ++L+ K K++ +
Sbjct: 535 WIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKII-T 593
Query: 371 VQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
+NIS PRGIAVHP ++FWTD NP+IE +++ G R V+ S
Sbjct: 594 KENISQPRGIAVHPMAKRLFWTD-TGINPRIESSSLQGLGRLVIASS 639
Score = 54.4 bits (125), Expect = 2e-07
Identities = 42/162 (25%), Positives = 76/162 (46%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIK 199
P FL+ S G SI+R+ + + E +++G+S V + +IYW D+ ++
Sbjct: 44 PAPFLIFSHGNSIFRIDTEGTNYEQLV-VDAGVS---VIMDFHYNEKRIYWVDLERQLLQ 99
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
R +GS E+ N + G+AI+W + W++ ++ I V ++ +L S
Sbjct: 100 RVFLNGSRQERVCNIEK-NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA-- 156
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ P +AV P IFW+ + + A++DG LL
Sbjct: 157 LKYPANVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALL 196
Score = 50.4 bits (115), Expect = 4e-06
Identities = 33/127 (25%), Positives = 66/127 (51%), Gaps = 2/127 (1%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDV-VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
++V + +++W D ++ I+ + G ++ +I P G+ ID+ ++W D+K
Sbjct: 603 IAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAK 662
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTE 490
+ IE+ANLD R+ L + ++ +P +AV ++++DW + P + N G +
Sbjct: 663 QSVIEMANLDGSKRRRL-TQNDVGHPFAVAVF--EDYVWFSDW--AMPSVIRVNKRTGKD 717
Query: 491 RSVLLGS 511
R L GS
Sbjct: 718 RVRLQGS 724
>BC113461-1|AAI13462.1| 1207|Homo sapiens epidermal growth factor
(beta-urogastrone) protein.
Length = 1207
Score = 103 bits (247), Expect = 4e-22
Identities = 60/167 (35%), Positives = 94/167 (56%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSN 190
PQP FL+ ++ I + F + ++ T ++ + V ++ D KIY+
Sbjct: 481 PQP---FLLFANSQDIRHMHFDGT--DYGTLLSQQMGMV-YALDHDPVENKIYFAHTALK 534
Query: 191 NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFS 370
I+RA DGS+ E+ + G+ PEGLA+DW R +WTD K I ++L+ K K++ +
Sbjct: 535 WIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKII-T 593
Query: 371 VQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
+NIS PRGIAVHP ++FWTD NP+IE +++ G R V+ S
Sbjct: 594 KENISQPRGIAVHPMAKRLFWTD-TGINPRIESSSLQGLGRLVIASS 639
Score = 54.4 bits (125), Expect = 2e-07
Identities = 42/162 (25%), Positives = 76/162 (46%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIK 199
P FL+ S G SI+R+ + + E +++G+S V + +IYW D+ ++
Sbjct: 44 PAPFLIFSHGNSIFRIDTEGTNYEQLV-VDAGVS---VIMDFHYNEKRIYWVDLERQLLQ 99
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
R +GS E+ N + G+AI+W + W++ ++ I V ++ +L S
Sbjct: 100 RVFLNGSRQERVCNIEK-NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA-- 156
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ P +AV P IFW+ + + A++DG LL
Sbjct: 157 LKYPANVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALL 196
Score = 50.4 bits (115), Expect = 4e-06
Identities = 33/127 (25%), Positives = 66/127 (51%), Gaps = 2/127 (1%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDV-VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
++V + +++W D ++ I+ + G ++ +I P G+ ID+ ++W D+K
Sbjct: 603 IAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAK 662
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTE 490
+ IE+ANLD R+ L + ++ +P +AV ++++DW + P + N G +
Sbjct: 663 QSVIEMANLDGSKRRRL-TQNDVGHPFAVAVF--EDYVWFSDW--AMPSVIRVNKRTGKD 717
Query: 491 RSVLLGS 511
R L GS
Sbjct: 718 RVRLQGS 724
>BC093731-1|AAH93731.1| 1207|Homo sapiens epidermal growth factor
(beta-urogastrone) protein.
Length = 1207
Score = 103 bits (247), Expect = 4e-22
Identities = 60/167 (35%), Positives = 94/167 (56%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSN 190
PQP FL+ ++ I + F + ++ T ++ + V ++ D KIY+
Sbjct: 481 PQP---FLLFANSQDIRHMHFDGT--DYGTLLSQQMGMV-YALDHDPVENKIYFAHTALK 534
Query: 191 NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFS 370
I+RA DGS+ E+ + G+ PEGLA+DW R +WTD K I ++L+ K K++ +
Sbjct: 535 WIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKII-T 593
Query: 371 VQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
+NIS PRGIAVHP ++FWTD NP+IE +++ G R V+ S
Sbjct: 594 KENISQPRGIAVHPMAKRLFWTD-TGINPRIESSSLQGLGRLVIASS 639
Score = 54.4 bits (125), Expect = 2e-07
Identities = 42/162 (25%), Positives = 76/162 (46%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIK 199
P FL+ S G SI+R+ + + E +++G+S V + +IYW D+ ++
Sbjct: 44 PAPFLIFSHGNSIFRIDTEGTNYEQLV-VDAGVS---VIMDFHYNEKRIYWVDLERQLLQ 99
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
R +GS E+ N + G+AI+W + W++ ++ I V ++ +L S
Sbjct: 100 RVFLNGSRQERVCNIEK-NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA-- 156
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ P +AV P IFW+ + + A++DG LL
Sbjct: 157 LKYPANVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALL 196
Score = 50.4 bits (115), Expect = 4e-06
Identities = 33/127 (25%), Positives = 66/127 (51%), Gaps = 2/127 (1%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDV-VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
++V + +++W D ++ I+ + G ++ +I P G+ ID+ ++W D+K
Sbjct: 603 IAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAK 662
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTE 490
+ IE+ANLD R+ L + ++ +P +AV ++++DW + P + N G +
Sbjct: 663 QSVIEMANLDGSKRRRL-TQNDVGHPFAVAVF--EDYVWFSDW--AMPSVIRVNKRTGKD 717
Query: 491 RSVLLGS 511
R L GS
Sbjct: 718 RVRLQGS 724
>AY506357-1|AAR84237.1| 1152|Homo sapiens truncated epidermal growth
factor (beta-urogastrone) protein.
Length = 1152
Score = 103 bits (247), Expect = 4e-22
Identities = 60/167 (35%), Positives = 94/167 (56%)
Frame = +2
Query: 11 PQPPGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSN 190
PQP FL+ ++ I + F + ++ T ++ + V ++ D KIY+
Sbjct: 481 PQP---FLLFANSQDIRHMHFDGT--DYGTLLSQQMGMV-YALDHDPVENKIYFAHTALK 534
Query: 191 NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFS 370
I+RA DGS+ E+ + G+ PEGLA+DW R +WTD K I ++L+ K K++ +
Sbjct: 535 WIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKII-T 593
Query: 371 VQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
+NIS PRGIAVHP ++FWTD NP+IE +++ G R V+ S
Sbjct: 594 KENISQPRGIAVHPMAKRLFWTD-TGINPRIESSSLQGLGRLVIASS 639
Score = 54.4 bits (125), Expect = 2e-07
Identities = 42/162 (25%), Positives = 76/162 (46%)
Frame = +2
Query: 20 PGNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIK 199
P FL+ S G SI+R+ + + E +++G+S V + +IYW D+ ++
Sbjct: 44 PAPFLIFSHGNSIFRIDTEGTNYEQLV-VDAGVS---VIMDFHYNEKRIYWVDLERQLLQ 99
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
R +GS E+ N + G+AI+W + W++ ++ I V ++ +L S
Sbjct: 100 RVFLNGSRQERVCNIEK-NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA-- 156
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
+ P +AV P IFW+ + + A++DG LL
Sbjct: 157 LKYPANVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALL 196
Score = 50.4 bits (115), Expect = 4e-06
Identities = 33/127 (25%), Positives = 66/127 (51%), Gaps = 2/127 (1%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDV-VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
++V + +++W D ++ I+ + G ++ +I P G+ ID+ ++W D+K
Sbjct: 603 IAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAK 662
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTE 490
+ IE+ANLD R+ L + ++ +P +AV ++++DW + P + N G +
Sbjct: 663 QSVIEMANLDGSKRRRL-TQNDVGHPFAVAVF--EDYVWFSDW--AMPSVIRVNKRTGKD 717
Query: 491 RSVLLGS 511
R L GS
Sbjct: 718 RVRLQGS 724
>AC117947-1|AAX88968.1| 346|Homo sapiens unknown protein.
Length = 346
Score = 101 bits (243), Expect = 1e-21
Identities = 51/114 (44%), Positives = 70/114 (61%)
Frame = +2
Query: 164 IYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLD 343
IYW D+ N I RA D + E + G+ EG+A+DW A NI+WTD IEVA L+
Sbjct: 4 IYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLN 63
Query: 344 TKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
R V+ S Q + PR IAVHP++G +FWT+W + P I A +DG+E+ VL+
Sbjct: 64 GSFRYVIIS-QGLDQPRSIAVHPEKGLLFWTEWGQM-PCIGKARLDGSEKVVLV 115
Score = 47.2 bits (107), Expect = 3e-05
Identities = 41/158 (25%), Positives = 72/158 (45%), Gaps = 2/158 (1%)
Frame = +2
Query: 23 GNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNN-IK 199
GN T G ++ V + I+ G+ Q S++V G ++W + I
Sbjct: 45 GNIYWTDHGFNLIEVARLNGSFRYVI-ISQGLDQPR-SIAVHPEKGLLFWTEWGQMPCIG 102
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQN 379
+A DGSE ++ GI P G++ID+ ++W D++ IE +L+T + + V +
Sbjct: 103 KARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREM--VLS 160
Query: 380 ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANM-DGTE 490
SN +V I+W+D +N + + D TE
Sbjct: 161 GSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATE 198
>Z75190-1|CAA99509.1| 699|Homo sapiens apolipoprotein E receptor 2
906 protein.
Length = 699
Score = 99.1 bits (236), Expect = 8e-21
Identities = 52/129 (40%), Positives = 77/129 (59%), Gaps = 4/129 (3%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRA----GYDGSEFEQFLNTGIISPEGLAIDWSARNIF 298
V++ V+ + +IYW D+ I A D E E ++ + SPEGLA+DW ++I+
Sbjct: 323 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEREVLIDEQLHSPEGLAVDWVHKHIY 382
Query: 299 WTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANM 478
WTDS TI VA +D R+ LFS +N+S PR IAV P RG ++W+DW KIE + +
Sbjct: 383 WTDSGNKTISVATVDGGRRRTLFS-RNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKSGL 440
Query: 479 DGTERSVLL 505
+G +R L+
Sbjct: 441 NGVDRQTLV 449
Score = 60.5 bits (140), Expect = 3e-09
Identities = 40/126 (31%), Positives = 67/126 (53%), Gaps = 3/126 (2%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++VD G +YW D I+++G +G + + ++ I P G+ +D ++ ++W DS
Sbjct: 414 AIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 473
Query: 311 KKLTIEVANLDTKVRKVLFSVQN-ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDG 484
K + + RK L S + +S+P GIAV K+FWTD N I AN ++G
Sbjct: 474 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF--EDKVFWTD--LENEAIFSANRLNG 529
Query: 485 TERSVL 502
E S+L
Sbjct: 530 LEISIL 535
>D86407-2|BAA21825.1| 793|Homo sapiens ApoER2delta4-7 protein.
Length = 793
Score = 99.1 bits (236), Expect = 8e-21
Identities = 52/129 (40%), Positives = 77/129 (59%), Gaps = 4/129 (3%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRA----GYDGSEFEQFLNTGIISPEGLAIDWSARNIF 298
V++ V+ + +IYW D+ I A D E E ++ + SPEGLA+DW ++I+
Sbjct: 283 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 342
Query: 299 WTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANM 478
WTDS TI VA +D R+ LFS +N+S PR IAV P RG ++W+DW KIE + +
Sbjct: 343 WTDSGNKTISVATVDGGRRRTLFS-RNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKSGL 400
Query: 479 DGTERSVLL 505
+G +R L+
Sbjct: 401 NGVDRQTLV 409
Score = 60.5 bits (140), Expect = 3e-09
Identities = 40/126 (31%), Positives = 67/126 (53%), Gaps = 3/126 (2%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++VD G +YW D I+++G +G + + ++ I P G+ +D ++ ++W DS
Sbjct: 374 AIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 433
Query: 311 KKLTIEVANLDTKVRKVLFSVQN-ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDG 484
K + + RK L S + +S+P GIAV K+FWTD N I AN ++G
Sbjct: 434 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF--EDKVFWTD--LENEAIFSANRLNG 489
Query: 485 TERSVL 502
E S+L
Sbjct: 490 LEISIL 495
>D86407-1|BAA21824.1| 963|Homo sapiens ApoER2 protein.
Length = 963
Score = 99.1 bits (236), Expect = 8e-21
Identities = 52/129 (40%), Positives = 77/129 (59%), Gaps = 4/129 (3%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRA----GYDGSEFEQFLNTGIISPEGLAIDWSARNIF 298
V++ V+ + +IYW D+ I A D E E ++ + SPEGLA+DW ++I+
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 299 WTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANM 478
WTDS TI VA +D R+ LFS +N+S PR IAV P RG ++W+DW KIE + +
Sbjct: 513 WTDSGNKTISVATVDGGRRRTLFS-RNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKSGL 570
Query: 479 DGTERSVLL 505
+G +R L+
Sbjct: 571 NGVDRQTLV 579
Score = 60.5 bits (140), Expect = 3e-09
Identities = 40/126 (31%), Positives = 67/126 (53%), Gaps = 3/126 (2%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++VD G +YW D I+++G +G + + ++ I P G+ +D ++ ++W DS
Sbjct: 544 AIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 603
Query: 311 KKLTIEVANLDTKVRKVLFSVQN-ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDG 484
K + + RK L S + +S+P GIAV K+FWTD N I AN ++G
Sbjct: 604 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF--EDKVFWTD--LENEAIFSANRLNG 659
Query: 485 TERSVL 502
E S+L
Sbjct: 660 LEISIL 665
>D50678-1|BAA09328.1| 963|Homo sapiens apolipoprotein E receptor 2
precursor protein.
Length = 963
Score = 99.1 bits (236), Expect = 8e-21
Identities = 52/129 (40%), Positives = 77/129 (59%), Gaps = 4/129 (3%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRA----GYDGSEFEQFLNTGIISPEGLAIDWSARNIF 298
V++ V+ + +IYW D+ I A D E E ++ + SPEGLA+DW ++I+
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 299 WTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANM 478
WTDS TI VA +D R+ LFS +N+S PR IAV P RG ++W+DW KIE + +
Sbjct: 513 WTDSGNKTISVATVDGGRRRTLFS-RNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKSGL 570
Query: 479 DGTERSVLL 505
+G +R L+
Sbjct: 571 NGVDRQTLV 579
Score = 60.5 bits (140), Expect = 3e-09
Identities = 40/126 (31%), Positives = 67/126 (53%), Gaps = 3/126 (2%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++VD G +YW D I+++G +G + + ++ I P G+ +D ++ ++W DS
Sbjct: 544 AIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 603
Query: 311 KKLTIEVANLDTKVRKVLFSVQN-ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDG 484
K + + RK L S + +S+P GIAV K+FWTD N I AN ++G
Sbjct: 604 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF--EDKVFWTD--LENEAIFSANRLNG 659
Query: 485 TERSVL 502
E S+L
Sbjct: 660 LEISIL 665
>BC051836-1|AAH51836.2| 904|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 904
Score = 99.1 bits (236), Expect = 8e-21
Identities = 52/129 (40%), Positives = 77/129 (59%), Gaps = 4/129 (3%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRA----GYDGSEFEQFLNTGIISPEGLAIDWSARNIF 298
V++ V+ + +IYW D+ I A D E E ++ + SPEGLA+DW ++I+
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 299 WTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANM 478
WTDS TI VA +D R+ LFS +N+S PR IAV P RG ++W+DW KIE + +
Sbjct: 513 WTDSGNKTISVATVDGGRRRTLFS-RNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKSGL 570
Query: 479 DGTERSVLL 505
+G +R L+
Sbjct: 571 NGVDRQTLV 579
Score = 60.5 bits (140), Expect = 3e-09
Identities = 40/126 (31%), Positives = 67/126 (53%), Gaps = 3/126 (2%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++VD G +YW D I+++G +G + + ++ I P G+ +D ++ ++W DS
Sbjct: 544 AIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 603
Query: 311 KKLTIEVANLDTKVRKVLFSVQN-ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDG 484
K + + RK L S + +S+P GIAV K+FWTD N I AN ++G
Sbjct: 604 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF--EDKVFWTD--LENEAIFSANRLNG 659
Query: 485 TERSVL 502
E S+L
Sbjct: 660 LEISIL 665
>AL606760-4|CAI18908.1| 963|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 963
Score = 99.1 bits (236), Expect = 8e-21
Identities = 52/129 (40%), Positives = 77/129 (59%), Gaps = 4/129 (3%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRA----GYDGSEFEQFLNTGIISPEGLAIDWSARNIF 298
V++ V+ + +IYW D+ I A D E E ++ + SPEGLA+DW ++I+
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 299 WTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANM 478
WTDS TI VA +D R+ LFS +N+S PR IAV P RG ++W+DW KIE + +
Sbjct: 513 WTDSGNKTISVATVDGGRRRTLFS-RNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKSGL 570
Query: 479 DGTERSVLL 505
+G +R L+
Sbjct: 571 NGVDRQTLV 579
Score = 60.5 bits (140), Expect = 3e-09
Identities = 40/126 (31%), Positives = 67/126 (53%), Gaps = 3/126 (2%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++VD G +YW D I+++G +G + + ++ I P G+ +D ++ ++W DS
Sbjct: 544 AIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 603
Query: 311 KKLTIEVANLDTKVRKVLFSVQN-ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDG 484
K + + RK L S + +S+P GIAV K+FWTD N I AN ++G
Sbjct: 604 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF--EDKVFWTD--LENEAIFSANRLNG 659
Query: 485 TERSVL 502
E S+L
Sbjct: 660 LEISIL 665
>AL606760-3|CAI18909.1| 700|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 700
Score = 99.1 bits (236), Expect = 8e-21
Identities = 52/129 (40%), Positives = 77/129 (59%), Gaps = 4/129 (3%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRA----GYDGSEFEQFLNTGIISPEGLAIDWSARNIF 298
V++ V+ + +IYW D+ I A D E E ++ + SPEGLA+DW ++I+
Sbjct: 324 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 383
Query: 299 WTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANM 478
WTDS TI VA +D R+ LFS +N+S PR IAV P RG ++W+DW KIE + +
Sbjct: 384 WTDSGNKTISVATVDGGRRRTLFS-RNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKSGL 441
Query: 479 DGTERSVLL 505
+G +R L+
Sbjct: 442 NGVDRQTLV 450
Score = 60.5 bits (140), Expect = 3e-09
Identities = 40/126 (31%), Positives = 67/126 (53%), Gaps = 3/126 (2%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++VD G +YW D I+++G +G + + ++ I P G+ +D ++ ++W DS
Sbjct: 415 AIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 474
Query: 311 KKLTIEVANLDTKVRKVLFSVQN-ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDG 484
K + + RK L S + +S+P GIAV K+FWTD N I AN ++G
Sbjct: 475 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF--EDKVFWTD--LENEAIFSANRLNG 530
Query: 485 TERSVL 502
E S+L
Sbjct: 531 LEISIL 536
>AL606760-2|CAI18910.1| 904|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 904
Score = 99.1 bits (236), Expect = 8e-21
Identities = 52/129 (40%), Positives = 77/129 (59%), Gaps = 4/129 (3%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRA----GYDGSEFEQFLNTGIISPEGLAIDWSARNIF 298
V++ V+ + +IYW D+ I A D E E ++ + SPEGLA+DW ++I+
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 299 WTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANM 478
WTDS TI VA +D R+ LFS +N+S PR IAV P RG ++W+DW KIE + +
Sbjct: 513 WTDSGNKTISVATVDGGRRRTLFS-RNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKSGL 570
Query: 479 DGTERSVLL 505
+G +R L+
Sbjct: 571 NGVDRQTLV 579
Score = 60.5 bits (140), Expect = 3e-09
Identities = 40/126 (31%), Positives = 67/126 (53%), Gaps = 3/126 (2%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++VD G +YW D I+++G +G + + ++ I P G+ +D ++ ++W DS
Sbjct: 544 AIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 603
Query: 311 KKLTIEVANLDTKVRKVLFSVQN-ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDG 484
K + + RK L S + +S+P GIAV K+FWTD N I AN ++G
Sbjct: 604 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF--EDKVFWTD--LENEAIFSANRLNG 659
Query: 485 TERSVL 502
E S+L
Sbjct: 660 LEISIL 665
>AL355483-3|CAI22781.1| 963|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 963
Score = 99.1 bits (236), Expect = 8e-21
Identities = 52/129 (40%), Positives = 77/129 (59%), Gaps = 4/129 (3%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRA----GYDGSEFEQFLNTGIISPEGLAIDWSARNIF 298
V++ V+ + +IYW D+ I A D E E ++ + SPEGLA+DW ++I+
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 299 WTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANM 478
WTDS TI VA +D R+ LFS +N+S PR IAV P RG ++W+DW KIE + +
Sbjct: 513 WTDSGNKTISVATVDGGRRRTLFS-RNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKSGL 570
Query: 479 DGTERSVLL 505
+G +R L+
Sbjct: 571 NGVDRQTLV 579
Score = 60.5 bits (140), Expect = 3e-09
Identities = 40/126 (31%), Positives = 67/126 (53%), Gaps = 3/126 (2%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++VD G +YW D I+++G +G + + ++ I P G+ +D ++ ++W DS
Sbjct: 544 AIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 603
Query: 311 KKLTIEVANLDTKVRKVLFSVQN-ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDG 484
K + + RK L S + +S+P GIAV K+FWTD N I AN ++G
Sbjct: 604 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF--EDKVFWTD--LENEAIFSANRLNG 659
Query: 485 TERSVL 502
E S+L
Sbjct: 660 LEISIL 665
>AL355483-2|CAI22782.1| 700|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 700
Score = 99.1 bits (236), Expect = 8e-21
Identities = 52/129 (40%), Positives = 77/129 (59%), Gaps = 4/129 (3%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRA----GYDGSEFEQFLNTGIISPEGLAIDWSARNIF 298
V++ V+ + +IYW D+ I A D E E ++ + SPEGLA+DW ++I+
Sbjct: 324 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 383
Query: 299 WTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANM 478
WTDS TI VA +D R+ LFS +N+S PR IAV P RG ++W+DW KIE + +
Sbjct: 384 WTDSGNKTISVATVDGGRRRTLFS-RNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKSGL 441
Query: 479 DGTERSVLL 505
+G +R L+
Sbjct: 442 NGVDRQTLV 450
Score = 60.5 bits (140), Expect = 3e-09
Identities = 40/126 (31%), Positives = 67/126 (53%), Gaps = 3/126 (2%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++VD G +YW D I+++G +G + + ++ I P G+ +D ++ ++W DS
Sbjct: 415 AIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 474
Query: 311 KKLTIEVANLDTKVRKVLFSVQN-ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDG 484
K + + RK L S + +S+P GIAV K+FWTD N I AN ++G
Sbjct: 475 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF--EDKVFWTD--LENEAIFSANRLNG 530
Query: 485 TERSVL 502
E S+L
Sbjct: 531 LEISIL 536
>AL355483-1|CAI22780.1| 904|Homo sapiens low density lipoprotein
receptor-related protein 8, apolipoprotein e receptor
protein.
Length = 904
Score = 99.1 bits (236), Expect = 8e-21
Identities = 52/129 (40%), Positives = 77/129 (59%), Gaps = 4/129 (3%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRA----GYDGSEFEQFLNTGIISPEGLAIDWSARNIF 298
V++ V+ + +IYW D+ I A D E E ++ + SPEGLA+DW ++I+
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
Query: 299 WTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANM 478
WTDS TI VA +D R+ LFS +N+S PR IAV P RG ++W+DW KIE + +
Sbjct: 513 WTDSGNKTISVATVDGGRRRTLFS-RNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKSGL 570
Query: 479 DGTERSVLL 505
+G +R L+
Sbjct: 571 NGVDRQTLV 579
Score = 60.5 bits (140), Expect = 3e-09
Identities = 40/126 (31%), Positives = 67/126 (53%), Gaps = 3/126 (2%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++VD G +YW D I+++G +G + + ++ I P G+ +D ++ ++W DS
Sbjct: 544 AIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 603
Query: 311 KKLTIEVANLDTKVRKVLFSVQN-ISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDG 484
K + + RK L S + +S+P GIAV K+FWTD N I AN ++G
Sbjct: 604 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF--EDKVFWTD--LENEAIFSANRLNG 659
Query: 485 TERSVL 502
E S+L
Sbjct: 660 LEISIL 665
>BC139736-1|AAI39737.1| 224|Homo sapiens LRP5L protein protein.
Length = 224
Score = 95.1 bits (226), Expect = 1e-19
Identities = 46/118 (38%), Positives = 72/118 (61%)
Frame = +2
Query: 158 GKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVAN 337
G +YW D I+RA DGS + +NT I P+ +A++W AR+++WT + IEV
Sbjct: 3 GHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTC 62
Query: 338 LDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
L++ K+L S +++ PR IA+HP+ G +W DW NP+I+ AN+D E VL+ +
Sbjct: 63 LNSTSHKILVS-EDMDEPRAIALHPEMGLTYWIDWG-ENPEIKRANLDRQELRVLVNA 118
Score = 46.8 bits (106), Expect = 5e-05
Identities = 31/102 (30%), Positives = 43/102 (42%), Gaps = 1/102 (0%)
Frame = +2
Query: 158 GKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
G YW D N IKRA D E +N + P GLA+D ++W D+K IE
Sbjct: 89 GLTYWIDWGENPEIKRANLDRQELRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAI 148
Query: 335 NLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
++D R+ L + P I+WT W + K
Sbjct: 149 SVDETKRQTLLKDK---LPHIFRFTLLGDFIYWTAWQHHSIK 187
>AK054663-1|BAB70786.1| 820|Homo sapiens umor (LRPDIT) mRNA.
protein.
Length = 820
Score = 94.3 bits (224), Expect = 2e-19
Identities = 48/117 (41%), Positives = 67/117 (57%), Gaps = 4/117 (3%)
Frame = +2
Query: 164 IYWGDVVSNNIKRAGYDGS----EFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEV 331
+YW DVV + I R S E + G+ +PEGL +DW A NI+W DS IEV
Sbjct: 485 LYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEV 544
Query: 332 ANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVL 502
A LD +R L + + +PR IA+ P+ G +FWTDW+ + P+IE A+M G R +
Sbjct: 545 AKLDGSLRTTLIA-GAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTI 600
Score = 47.2 bits (107), Expect = 3e-05
Identities = 38/120 (31%), Positives = 59/120 (49%), Gaps = 3/120 (2%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWT--DS 310
++VD +G IYW D + I+ A DGS + + P +A+D +FWT D+
Sbjct: 523 LTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDA 582
Query: 311 KKLTIEVANLDTKVRKVLF-SVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
IE A++ RK ++ ++ + P G+ V +I WTD RS+ I A DGT
Sbjct: 583 NFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTD-ARSD-AIYSALYDGT 640
Score = 44.4 bits (100), Expect = 2e-04
Identities = 35/141 (24%), Positives = 70/141 (49%), Gaps = 6/141 (4%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSN--NIKRAGYDGSEFEQF---LNTGIISPE 262
T + +G + ++++D G ++W D +N I+ A G+ + + TG P
Sbjct: 553 TTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAW-PN 611
Query: 263 GLAIDWSARNIFWTDSKKLTIEVANLD-TKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
GL +D + I WTD++ I A D T + +++ + +S+P ++++ +++WTD
Sbjct: 612 GLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGS--EVYWTD 669
Query: 440 WNRSNPKIEWANMDGTERSVL 502
W R+N + G SV+
Sbjct: 670 W-RTNTLSKANKWTGQNVSVI 689
>AC010740-1|AAY14689.1| 862|Homo sapiens unknown protein.
Length = 862
Score = 94.3 bits (224), Expect = 2e-19
Identities = 48/117 (41%), Positives = 67/117 (57%), Gaps = 4/117 (3%)
Frame = +2
Query: 164 IYWGDVVSNNIKRAGYDGS----EFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEV 331
+YW DVV + I R S E + G+ +PEGL +DW A NI+W DS IEV
Sbjct: 378 LYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEV 437
Query: 332 ANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVL 502
A LD +R L + + +PR IA+ P+ G +FWTDW+ + P+IE A+M G R +
Sbjct: 438 AKLDGSLRTTLIA-GAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTI 493
Score = 90.6 bits (215), Expect = 3e-18
Identities = 48/131 (36%), Positives = 73/131 (55%), Gaps = 2/131 (1%)
Frame = +2
Query: 116 ISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
I V V + D ++YW D+ + IKRA +G+ E ++ I S GLA+DW +RN+
Sbjct: 681 IDDVTV-IDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNL 739
Query: 296 FWTDSK--KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEW 469
+W S+ + I VA LD ++ + + I P+ +A HP RGK++WTD N I
Sbjct: 740 YWISSEFDETQINVARLDGSLKTSI--IHGIDKPQCLAAHPVRGKLYWTDGN----TINM 793
Query: 470 ANMDGTERSVL 502
ANMDG+ +L
Sbjct: 794 ANMDGSNSKIL 804
Score = 47.2 bits (107), Expect = 3e-05
Identities = 38/120 (31%), Positives = 59/120 (49%), Gaps = 3/120 (2%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWT--DS 310
++VD +G IYW D + I+ A DGS + + P +A+D +FWT D+
Sbjct: 416 LTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDA 475
Query: 311 KKLTIEVANLDTKVRKVLF-SVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
IE A++ RK ++ ++ + P G+ V +I WTD RS+ I A DGT
Sbjct: 476 NFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTD-ARSD-AIYSALYDGT 533
Score = 44.4 bits (100), Expect = 2e-04
Identities = 35/141 (24%), Positives = 70/141 (49%), Gaps = 6/141 (4%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSN--NIKRAGYDGSEFEQF---LNTGIISPE 262
T + +G + ++++D G ++W D +N I+ A G+ + + TG P
Sbjct: 446 TTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAW-PN 504
Query: 263 GLAIDWSARNIFWTDSKKLTIEVANLD-TKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
GL +D + I WTD++ I A D T + +++ + +S+P ++++ +++WTD
Sbjct: 505 GLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGS--EVYWTD 562
Query: 440 WNRSNPKIEWANMDGTERSVL 502
W R+N + G SV+
Sbjct: 563 W-RTNTLSKANKWTGQNVSVI 582
Score = 42.3 bits (95), Expect = 0.001
Identities = 26/73 (35%), Positives = 36/73 (49%)
Frame = +2
Query: 158 GKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVAN 337
GK+YW D N I A DGS + L P GL+ID+ ++W S TI N
Sbjct: 781 GKLYWTD--GNTINMANMDGSN-SKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCN 837
Query: 338 LDTKVRKVLFSVQ 376
LD +V+ S++
Sbjct: 838 LDGGNLEVIESMK 850
Score = 35.5 bits (78), Expect = 0.11
Identities = 21/81 (25%), Positives = 41/81 (50%)
Frame = +2
Query: 275 DWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSN 454
D S ++WTD K TI+ A ++ + + S ++I + RG+AV ++W
Sbjct: 690 DASEERLYWTDIKTQTIKRAFINGTGLETVIS-RDIQSIRGLAVDWVSRNLYWISSEFDE 748
Query: 455 PKIEWANMDGTERSVLLGSPD 517
+I A +DG+ ++ ++ D
Sbjct: 749 TQINVARLDGSLKTSIIHGID 769
>AC008178-1|AAY24266.1| 773|Homo sapiens unknown protein.
Length = 773
Score = 94.3 bits (224), Expect = 2e-19
Identities = 49/142 (34%), Positives = 76/142 (53%), Gaps = 2/142 (1%)
Frame = +2
Query: 86 REFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEG 265
R F + S VAV V+ +++W D V N + +G ++ LN + +PE
Sbjct: 412 RSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPEN 471
Query: 266 LAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
LA+DW I+ ++K I++ NLD R L + +N+ +PRGIAV P G +F++DW
Sbjct: 472 LAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLIT-ENLGHPRGIAVDPTVGYLFFSDWE 530
Query: 446 --RSNPKIEWANMDGTERSVLL 505
PK+E A MDG+ R L+
Sbjct: 531 SLSGEPKLERAFMDGSNRKDLV 552
Score = 50.4 bits (115), Expect = 4e-06
Identities = 31/109 (28%), Positives = 58/109 (53%), Gaps = 5/109 (4%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNN----IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWT 304
++VD G +++ D S + ++RA DGS + + T + P G+ +D ++ ++W
Sbjct: 515 IAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWV 574
Query: 305 DSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
DS+ IE D RK V+ I +P G+++ G++F+TDW +
Sbjct: 575 DSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLF--EGQVFFTDWTK 621
Score = 41.9 bits (94), Expect = 0.001
Identities = 23/91 (25%), Positives = 44/91 (48%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
V++D S ++YW D + I+ YDG + + ++ G + P + +F+TD K
Sbjct: 562 VTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTK 621
Query: 317 LTIEVANLDTKVRKVLFSVQNISNPRGIAVH 409
+ + AN T+ ++ Q P G+ V+
Sbjct: 622 MAVLKANKFTETNPQVY-YQASLRPYGVTVY 651
Score = 30.7 bits (66), Expect = 3.2
Identities = 18/65 (27%), Positives = 29/65 (44%)
Frame = +2
Query: 26 NFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRA 205
NFL+ S +I +PF S +E SG V + D I++ D+ + I +
Sbjct: 709 NFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQ 768
Query: 206 GYDGS 220
DG+
Sbjct: 769 KIDGT 773
>AB209498-1|BAD92735.1| 2359|Homo sapiens low density
lipoprotein-related protein 1 variant protein.
Length = 2359
Score = 93.1 bits (221), Expect = 5e-19
Identities = 50/138 (36%), Positives = 76/138 (55%), Gaps = 2/138 (1%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSNN--IKRAGYDGSEFEQFLNTGIISPEGLA 271
T + G++ AV++ D IYW DV + I+R +GS + TG+ +P+GLA
Sbjct: 866 TLLKQGLNN-AVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLA 924
Query: 272 IDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRS 451
+DW N++W D + TIEV+ L+ R VL S + PR + V Q G ++WTDW
Sbjct: 925 VDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVS-SGLREPRALVVDVQNGYLYWTDWG-D 982
Query: 452 NPKIEWANMDGTERSVLL 505
+ I MDG+ RSV++
Sbjct: 983 HSLIGRIGMDGSSRSVIV 1000
Score = 86.2 bits (204), Expect = 6e-17
Identities = 42/88 (47%), Positives = 56/88 (63%)
Frame = +2
Query: 242 TGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRG 421
+G+ P G+AIDW A N++WTDS + IEVA + + RK L S I P I V P RG
Sbjct: 1770 SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGM-IDEPHAIVVDPLRG 1828
Query: 422 KIFWTDWNRSNPKIEWANMDGTERSVLL 505
++W+DW ++PKIE A MDGT R L+
Sbjct: 1829 TMYWSDWG-NHPKIETAAMDGTLRETLV 1855
Score = 66.1 bits (154), Expect = 7e-11
Identities = 45/138 (32%), Positives = 74/138 (53%), Gaps = 2/138 (1%)
Frame = +2
Query: 104 INSGISQVAVSVSVDCFSGKIYWGDVVSNN-IKRAGYDGSEFEQFLNTGIISPEGLAIDW 280
++SG+ + V VD +G +YW D ++ I R G DGS ++T I P GL +D+
Sbjct: 956 VSSGLREPRALV-VDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDY 1014
Query: 281 SARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
I+W D+++ IE A+LD R V+ S Q+I P A+ ++WTDW +
Sbjct: 1015 VTERIYWADAREDYIEFASLDGSNRHVVLS-QDI--PHIFALTLFEDYVYWTDWETKS-- 1069
Query: 461 IEWAN-MDGTERSVLLGS 511
I A+ GT +++L+ +
Sbjct: 1070 INRAHKTTGTNKTLLIST 1087
Score = 50.4 bits (115), Expect = 4e-06
Identities = 29/115 (25%), Positives = 54/115 (46%), Gaps = 1/115 (0%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAID 277
T +N ++ +++D +G +YW D + I+ A G + ++ I P + +D
Sbjct: 1765 THLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVD 1824
Query: 278 WSARNIFWTD-SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
++W+D IE A +D +R+ L NI P G+AV +++W D
Sbjct: 1825 PLRGTMYWSDWGNHPKIETAAMDGTLRETLVQ-DNIQWPTGLAVDYHNERLYWAD 1878
Score = 50.0 bits (114), Expect = 5e-06
Identities = 29/86 (33%), Positives = 45/86 (52%)
Frame = +2
Query: 191 NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFS 370
+I RA G+ + I +P GLAID A ++++D+ IE D R V+
Sbjct: 173 SIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILK 232
Query: 371 VQNISNPRGIAVHPQRGKIFWTDWNR 448
+ + +P G+AV+ + IFWTDW R
Sbjct: 233 SEPV-HPFGLAVYGEH--IFWTDWVR 255
Score = 46.8 bits (106), Expect = 5e-05
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 5/120 (4%)
Frame = +2
Query: 161 KIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANL 340
+I++ D+ NI++ DGS + + S EGLA ++WT TI +
Sbjct: 70 RIFFSDIHFGNIQQINDDGSRRITIVEN-VGSVEGLAYHRGWDTLYWTSYTTSTITRHTV 128
Query: 341 DTK-----VRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
D R+ + ++ +PR + + +FWT+WN +P I A + G L+
Sbjct: 129 DQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLI 188
Score = 45.6 bits (103), Expect = 1e-04
Identities = 27/88 (30%), Positives = 42/88 (47%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
+++D + K+Y+ D + I+R YDGS L + + P GLA+ +IFWTD +
Sbjct: 198 LAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAV--YGEHIFWTDWVR 255
Query: 317 LTIEVANLDTKVRKVLFSVQNISNPRGI 400
++ AN L V P GI
Sbjct: 256 RAVQRANKHVGSNMKLLRVDIPQQPMGI 283
Score = 45.2 bits (102), Expect = 1e-04
Identities = 36/130 (27%), Positives = 56/130 (43%), Gaps = 2/130 (1%)
Frame = +2
Query: 23 GNFLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSN-NIK 199
GN T G + V E + SG+ ++ VD G +YW D ++ I+
Sbjct: 1785 GNVYWTDSGRDVIEVA--QMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIE 1842
Query: 200 RAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLD-TKVRKVLFSVQ 376
A DG+ E + I P GLA+D+ ++W D+K I L+ T S +
Sbjct: 1843 TAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKR 1902
Query: 377 NISNPRGIAV 406
+S+P I V
Sbjct: 1903 GLSHPFSIDV 1912
Score = 34.7 bits (76), Expect = 0.20
Identities = 17/46 (36%), Positives = 24/46 (52%)
Frame = +2
Query: 368 SVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
++ + PRGIA+ G ++WTD R IE A M G R L+
Sbjct: 1768 NISGLKMPRGIAIDWVAGNVYWTDSGRD--VIEVAQMKGENRKTLI 1811
>S73145-1|AAB30825.1| 268|Homo sapiens calcium sensor protein
protein.
Length = 268
Score = 89.4 bits (212), Expect = 7e-18
Identities = 40/86 (46%), Positives = 60/86 (69%)
Frame = +2
Query: 248 IISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKI 427
++ P+G+A+DW R+I+W+D K IEVA LD + RK L S ++ P IAV+P+ G +
Sbjct: 3 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLIST-DLDQPAAIAVNPKLGLM 61
Query: 428 FWTDWNRSNPKIEWANMDGTERSVLL 505
FWTDW + PKIE A M+G +R++L+
Sbjct: 62 FWTDWGK-EPKIESAWMNGEDRNILV 86
>U04441-1|AAB02882.1| 1751|Homo sapiens glycoprotein 330 protein.
Length = 1751
Score = 85.8 bits (203), Expect = 8e-17
Identities = 38/86 (44%), Positives = 59/86 (68%)
Frame = +2
Query: 248 IISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKI 427
++ P+G+A+DW R+I+W+D K IEVA LD + RK L S ++ P IAV+P+ G +
Sbjct: 1439 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLIST-DLDQPAAIAVNPKLGLM 1497
Query: 428 FWTDWNRSNPKIEWANMDGTERSVLL 505
FWTDW + PK+E A M+G + ++L+
Sbjct: 1498 FWTDWGK-EPKLESAWMNGEDPNILV 1522
Score = 78.6 bits (185), Expect = 1e-14
Identities = 45/147 (30%), Positives = 77/147 (52%), Gaps = 7/147 (4%)
Frame = +2
Query: 92 FATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLA 271
F + I G+ V V++ D ++YW D I+R + + E +N + + E LA
Sbjct: 515 FYSLILEGLDNV-VALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLA 573
Query: 272 IDWSARNIFWTDSKKLTIEVANLDTKVRKVL----FSVQN---ISNPRGIAVHPQRGKIF 430
+DW +R ++W D++ + V++L+ R++L N NPRG+A+HPQ G ++
Sbjct: 574 VDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLY 633
Query: 431 WTDWNRSNPKIEWANMDGTERSVLLGS 511
W DW I MDGT +SV++ +
Sbjct: 634 WADWGH-RAYIGRVGMDGTNKSVIIST 659
Score = 52.8 bits (121), Expect = 7e-07
Identities = 35/120 (29%), Positives = 58/120 (48%), Gaps = 2/120 (1%)
Frame = +2
Query: 158 GKIYWGDVVSNN-IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVA 334
G +YW D I R G DG+ ++T + P G+ ID++ ++W D+ IE +
Sbjct: 630 GYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYS 689
Query: 335 NLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN-MDGTERSVLLGS 511
+L+ R +V + + P A+ I+WTDWN +E N DG+ R L+ +
Sbjct: 690 DLEGHHR---HTVYDGALPHPFAITIFEDTIYWTDWNTRT--VEKGNKYDGSNRQTLVNT 744
Score = 30.3 bits (65), Expect = 4.3
Identities = 18/54 (33%), Positives = 29/54 (53%)
Frame = +2
Query: 350 VRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
V++V ++ + P GIAV I+W+D N +IE A +DG R L+ +
Sbjct: 1429 VQEVDLKLKYVMQPDGIAVDWVGRHIYWSD--VKNKRIEVAKLDGRYRKWLIST 1480
>AF283342-1|AAL38107.1| 881|Homo sapiens candidate tumor suppressor
protein protein.
Length = 881
Score = 85.0 bits (201), Expect = 1e-16
Identities = 53/149 (35%), Positives = 80/149 (53%), Gaps = 8/149 (5%)
Frame = +2
Query: 89 EFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGL 268
E+ PI + ++ A+ + + IY+ D S I R DG+E E L + + EG+
Sbjct: 547 EYMIPIENLVNPRALDFHAE--TNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGI 604
Query: 269 AIDWSARNIFWT-DSKKLTIEVANLD--TKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
A+DW N++WT D + TI VA L+ ++ RK L + +S+PRGI V P G ++WTD
Sbjct: 605 AVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGE-MSHPRGIVVDPVNGWMYWTD 663
Query: 440 WNR-----SNPKIEWANMDGTERSVLLGS 511
W S +IE A MDG R + + S
Sbjct: 664 WEEDEIDDSVGRIEKAWMDGFNRQIFVTS 692
Score = 55.2 bits (127), Expect = 1e-07
Identities = 30/82 (36%), Positives = 48/82 (58%)
Frame = +2
Query: 266 LAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWN 445
+AIDW RN+++ D I V N + V L ++ + NP+ IAV P GK+F+TD+
Sbjct: 288 MAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLE-LHNPKAIAVDPIAGKLFFTDYG 346
Query: 446 RSNPKIEWANMDGTERSVLLGS 511
+ K+E +MDG R+ ++ S
Sbjct: 347 -NVAKVERCDMDGMNRTRIIDS 367
Score = 54.0 bits (124), Expect = 3e-07
Identities = 30/109 (27%), Positives = 58/109 (53%), Gaps = 7/109 (6%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNI-------KRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
+ VD +G +YW D + I ++A DG + F+ + ++ P GL +D+ +
Sbjct: 650 IVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTL 709
Query: 296 FWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
+W D+ IE L+ RK+++S + +++P G++ H +FWTD+
Sbjct: 710 YWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHH--GNYVFWTDY 756
Score = 35.1 bits (77), Expect = 0.15
Identities = 20/92 (21%), Positives = 44/92 (47%), Gaps = 1/92 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVS-NNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++VD +GK+++ D + ++R DG + +++ P LA+D + ++W D
Sbjct: 330 AIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDL 389
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAV 406
+ V + K R + + + + GI V
Sbjct: 390 YLDYVGVVDYQGKNRHTVIQGRQVRHLYGITV 421
Score = 33.5 bits (73), Expect = 0.46
Identities = 21/102 (20%), Positives = 47/102 (46%), Gaps = 1/102 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
+++D + +Y+ D V + I +GS ++ + +P+ +A+D A +F+TD
Sbjct: 288 MAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGN 347
Query: 317 LT-IEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
+ +E ++D R + P +A+ ++W D
Sbjct: 348 VAKVERCDMDGMNRTRIID-SKTEQPAALALDLVNKLVYWVD 388
>AC073319-1|AAX93075.1| 585|Homo sapiens unknown protein.
Length = 585
Score = 85.0 bits (201), Expect = 1e-16
Identities = 53/149 (35%), Positives = 80/149 (53%), Gaps = 8/149 (5%)
Frame = +2
Query: 89 EFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGL 268
E+ PI + ++ A+ + + IY+ D S I R DG+E E L + + EG+
Sbjct: 209 EYMIPIENLVNPRALDFHAE--TNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGI 266
Query: 269 AIDWSARNIFWT-DSKKLTIEVANLD--TKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
A+DW N++WT D + TI VA L+ ++ RK L + +S+PRGI V P G ++WTD
Sbjct: 267 AVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGE-MSHPRGIVVDPVNGWMYWTD 325
Query: 440 WNR-----SNPKIEWANMDGTERSVLLGS 511
W S +IE A MDG R + + S
Sbjct: 326 WEEDEIDDSVGRIEKAWMDGFNRQIFVTS 354
Score = 54.0 bits (124), Expect = 3e-07
Identities = 30/109 (27%), Positives = 58/109 (53%), Gaps = 7/109 (6%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNI-------KRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
+ VD +G +YW D + I ++A DG + F+ + ++ P GL +D+ +
Sbjct: 312 IVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTL 371
Query: 296 FWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDW 442
+W D+ IE L+ RK+++S + +++P G++ H +FWTD+
Sbjct: 372 YWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHH--GNYVFWTDY 418
>L00352-1|AAA56833.1| 860|Homo sapiens low density lipoprotein
receptor protein.
Length = 860
Score = 83.0 bits (196), Expect = 6e-16
Identities = 45/125 (36%), Positives = 70/125 (56%), Gaps = 5/125 (4%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGD-----VVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
V++ + S +IYW D + S + RA + S ++ ++ I +P+GLA+DW NI
Sbjct: 430 VALDTEVASNRIYWSDLSQRMICSTQLDRA-HGVSSYDTVISRDIQAPDGLAVDWIHSNI 488
Query: 296 FWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN 475
+WTDS T+ VA+ RK LF +N S PR I V P G ++WTDW + KI+
Sbjct: 489 YWTDSVLGTVSVADTKGVKRKTLFR-ENGSKPRAIVVDPVHGFMYWTDWG-TPAKIKKGG 546
Query: 476 MDGTE 490
++G +
Sbjct: 547 LNGVD 551
Score = 51.6 bits (118), Expect = 2e-06
Identities = 30/104 (28%), Positives = 53/104 (50%), Gaps = 2/104 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDV-VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ VD G +YW D IK+ G +G + + I P G+ +D + ++W DS
Sbjct: 521 AIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDS 580
Query: 311 KKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTD 439
K +I +++ RK +L + +++P +AV K+FWTD
Sbjct: 581 KLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVF--EDKVFWTD 622
>BT007361-1|AAP36025.1| 860|Homo sapiens low density lipoprotein
receptor (familial hypercholesterolemia) protein.
Length = 860
Score = 83.0 bits (196), Expect = 6e-16
Identities = 45/125 (36%), Positives = 70/125 (56%), Gaps = 5/125 (4%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGD-----VVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
V++ + S +IYW D + S + RA + S ++ ++ I +P+GLA+DW NI
Sbjct: 430 VALDTEVASNRIYWSDLSQRMICSTQLDRA-HGVSSYDTVISRDIQAPDGLAVDWIHSNI 488
Query: 296 FWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN 475
+WTDS T+ VA+ RK LF +N S PR I V P G ++WTDW + KI+
Sbjct: 489 YWTDSVLGTVSVADTKGVKRKTLFR-ENGSKPRAIVVDPVHGFMYWTDWG-TPAKIKKGG 546
Query: 476 MDGTE 490
++G +
Sbjct: 547 LNGVD 551
Score = 51.6 bits (118), Expect = 2e-06
Identities = 30/104 (28%), Positives = 53/104 (50%), Gaps = 2/104 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDV-VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ VD G +YW D IK+ G +G + + I P G+ +D + ++W DS
Sbjct: 521 AIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDS 580
Query: 311 KKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTD 439
K +I +++ RK +L + +++P +AV K+FWTD
Sbjct: 581 KLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVF--EDKVFWTD 622
>BC014514-1|AAH14514.1| 860|Homo sapiens low density lipoprotein
receptor (familial hypercholesterolemia) protein.
Length = 860
Score = 83.0 bits (196), Expect = 6e-16
Identities = 45/125 (36%), Positives = 70/125 (56%), Gaps = 5/125 (4%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGD-----VVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
V++ + S +IYW D + S + RA + S ++ ++ I +P+GLA+DW NI
Sbjct: 430 VALDTEVASNRIYWSDLSQRMICSTQLDRA-HGVSSYDTVISRDIQAPDGLAVDWIHSNI 488
Query: 296 FWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN 475
+WTDS T+ VA+ RK LF +N S PR I V P G ++WTDW + KI+
Sbjct: 489 YWTDSVLGTVSVADTKGVKRKTLFR-ENGSKPRAIVVDPVHGFMYWTDWG-TPAKIKKGG 546
Query: 476 MDGTE 490
++G +
Sbjct: 547 LNGVD 551
Score = 51.6 bits (118), Expect = 2e-06
Identities = 30/104 (28%), Positives = 53/104 (50%), Gaps = 2/104 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDV-VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ VD G +YW D IK+ G +G + + I P G+ +D + ++W DS
Sbjct: 521 AIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDS 580
Query: 311 KKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTD 439
K +I +++ RK +L + +++P +AV K+FWTD
Sbjct: 581 KLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVF--EDKVFWTD 622
>AY324609-1|AAP72971.1| 860|Homo sapiens low density lipoprotein
receptor protein.
Length = 860
Score = 83.0 bits (196), Expect = 6e-16
Identities = 45/125 (36%), Positives = 70/125 (56%), Gaps = 5/125 (4%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGD-----VVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
V++ + S +IYW D + S + RA + S ++ ++ I +P+GLA+DW NI
Sbjct: 430 VALDTEVASNRIYWSDLSQRMICSTQLDRA-HGVSSYDTVISRDIQAPDGLAVDWIHSNI 488
Query: 296 FWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN 475
+WTDS T+ VA+ RK LF +N S PR I V P G ++WTDW + KI+
Sbjct: 489 YWTDSVLGTVSVADTKGVKRKTLFR-ENGSKPRAIVVDPVHGFMYWTDWG-TPAKIKKGG 546
Query: 476 MDGTE 490
++G +
Sbjct: 547 LNGVD 551
Score = 51.6 bits (118), Expect = 2e-06
Identities = 30/104 (28%), Positives = 53/104 (50%), Gaps = 2/104 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDV-VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ VD G +YW D IK+ G +G + + I P G+ +D + ++W DS
Sbjct: 521 AIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDS 580
Query: 311 KKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTD 439
K +I +++ RK +L + +++P +AV K+FWTD
Sbjct: 581 KLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVF--EDKVFWTD 622
>AY114155-1|AAM56036.1| 860|Homo sapiens low density lipoprotein
receptor protein.
Length = 860
Score = 83.0 bits (196), Expect = 6e-16
Identities = 45/125 (36%), Positives = 70/125 (56%), Gaps = 5/125 (4%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGD-----VVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
V++ + S +IYW D + S + RA + S ++ ++ I +P+GLA+DW NI
Sbjct: 430 VALDTEVASNRIYWSDLSQRMICSTQLDRA-HGVSSYDTVISRDIQAPDGLAVDWIHSNI 488
Query: 296 FWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN 475
+WTDS T+ VA+ RK LF +N S PR I V P G ++WTDW + KI+
Sbjct: 489 YWTDSVLGTVSVADTKGVKRKTLFR-ENGSKPRAIVVDPVHGFMYWTDWG-TPAKIKKGG 546
Query: 476 MDGTE 490
++G +
Sbjct: 547 LNGVD 551
Score = 51.6 bits (118), Expect = 2e-06
Identities = 30/104 (28%), Positives = 53/104 (50%), Gaps = 2/104 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDV-VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ VD G +YW D IK+ G +G + + I P G+ +D + ++W DS
Sbjct: 521 AIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDS 580
Query: 311 KKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTD 439
K +I +++ RK +L + +++P +AV K+FWTD
Sbjct: 581 KLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVF--EDKVFWTD 622
>AF217403-1|AAF24515.1| 837|Homo sapiens low density lipoprotein
receptor protein.
Length = 837
Score = 83.0 bits (196), Expect = 6e-16
Identities = 45/125 (36%), Positives = 70/125 (56%), Gaps = 5/125 (4%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGD-----VVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
V++ + S +IYW D + S + RA + S ++ ++ I +P+GLA+DW NI
Sbjct: 407 VALDTEVASNRIYWSDLSQRMICSTQLDRA-HGVSSYDTVISRDIQAPDGLAVDWIHSNI 465
Query: 296 FWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN 475
+WTDS T+ VA+ RK LF +N S PR I V P G ++WTDW + KI+
Sbjct: 466 YWTDSVLGTVSVADTKGVKRKTLFR-ENGSKPRAIVVDPVHGFMYWTDWG-TPAKIKKGG 523
Query: 476 MDGTE 490
++G +
Sbjct: 524 LNGVD 528
Score = 51.6 bits (118), Expect = 2e-06
Identities = 30/104 (28%), Positives = 53/104 (50%), Gaps = 2/104 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDV-VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ VD G +YW D IK+ G +G + + I P G+ +D + ++W DS
Sbjct: 498 AIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDS 557
Query: 311 KKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTD 439
K +I +++ RK +L + +++P +AV K+FWTD
Sbjct: 558 KLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVF--EDKVFWTD 599
>AB209409-1|BAD92646.1| 870|Homo sapiens low density lipoprotein
receptor precursor variant protein.
Length = 870
Score = 83.0 bits (196), Expect = 6e-16
Identities = 45/125 (36%), Positives = 70/125 (56%), Gaps = 5/125 (4%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGD-----VVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNI 295
V++ + S +IYW D + S + RA + S ++ ++ I +P+GLA+DW NI
Sbjct: 442 VALDTEVASNRIYWSDLSQRMICSTQLDRA-HGVSSYDTVISRDIQAPDGLAVDWIHSNI 500
Query: 296 FWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWAN 475
+WTDS T+ VA+ RK LF +N S PR I V P G ++WTDW + KI+
Sbjct: 501 YWTDSVLGTVSVADTKGVKRKTLFR-ENGSKPRAIVVDPVHGFMYWTDWG-TPAKIKKGG 558
Query: 476 MDGTE 490
++G +
Sbjct: 559 LNGVD 563
Score = 51.6 bits (118), Expect = 2e-06
Identities = 30/104 (28%), Positives = 53/104 (50%), Gaps = 2/104 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDV-VSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
++ VD G +YW D IK+ G +G + + I P G+ +D + ++W DS
Sbjct: 533 AIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDS 592
Query: 311 KKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTD 439
K +I +++ RK +L + +++P +AV K+FWTD
Sbjct: 593 KLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVF--EDKVFWTD 634
>S73849-1|AAB31735.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 82.2 bits (194), Expect = 1e-15
Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 1/126 (0%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQF-LNTGIISPEGLAIDWSARNIFWTD 307
V++ D + K++W D+ I A D + + +P +A+DW + I+WTD
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ TI VA LD RK LF+ ++ P IAV P G ++W+DW KIE A M+G
Sbjct: 532 AASKTISVATLDGTKRKFLFN-SDLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGF 589
Query: 488 ERSVLL 505
+R L+
Sbjct: 590 DRRPLV 595
Score = 55.2 bits (127), Expect = 1e-07
Identities = 38/138 (27%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Frame = +2
Query: 107 NSGISQVAVSVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWS 283
NS + + A S++VD SG +YW D I++AG +G + + I P G+ +D
Sbjct: 552 NSDLREPA-SIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
Query: 284 ARNIFWTDSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
++W DSK + +L+ + R+ VL S++ +++P + + R ++W D N
Sbjct: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDR--VYWID--GENEA 666
Query: 461 IEWAN-MDGTERSVLLGS 511
+ AN G+E + L+ +
Sbjct: 667 VYGANKFTGSELATLVNN 684
>L22431-1|AAA61344.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 82.2 bits (194), Expect = 1e-15
Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 1/126 (0%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQF-LNTGIISPEGLAIDWSARNIFWTD 307
V++ D + K++W D+ I A D + + +P +A+DW + I+WTD
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ TI VA LD RK LF+ ++ P IAV P G ++W+DW KIE A M+G
Sbjct: 532 AASKTISVATLDGTKRKFLFN-SDLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGF 589
Query: 488 ERSVLL 505
+R L+
Sbjct: 590 DRRPLV 595
Score = 55.2 bits (127), Expect = 1e-07
Identities = 38/138 (27%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Frame = +2
Query: 107 NSGISQVAVSVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWS 283
NS + + A S++VD SG +YW D I++AG +G + + I P G+ +D
Sbjct: 552 NSDLREPA-SIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
Query: 284 ARNIFWTDSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
++W DSK + +L+ + R+ VL S++ +++P + + R ++W D N
Sbjct: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDR--VYWID--GENEA 666
Query: 461 IEWAN-MDGTERSVLLGS 511
+ AN G+E + L+ +
Sbjct: 667 VYGANKFTGSELATLVNN 684
>L20470-1|AAA53684.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 82.2 bits (194), Expect = 1e-15
Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 1/126 (0%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQF-LNTGIISPEGLAIDWSARNIFWTD 307
V++ D + K++W D+ I A D + + +P +A+DW + I+WTD
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ TI VA LD RK LF+ ++ P IAV P G ++W+DW KIE A M+G
Sbjct: 532 AASKTISVATLDGTKRKFLFN-SDLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGF 589
Query: 488 ERSVLL 505
+R L+
Sbjct: 590 DRRPLV 595
Score = 56.0 bits (129), Expect = 8e-08
Identities = 38/138 (27%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Frame = +2
Query: 107 NSGISQVAVSVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWS 283
NS + + A S++VD SG +YW D I++AG +G + + I P G+ +D
Sbjct: 552 NSDLREPA-SIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
Query: 284 ARNIFWTDSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
++W DSK + +L+ + R+ VL S++ +++P + + R ++W D N
Sbjct: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDR--VYWID--GENEA 666
Query: 461 IEWAN-MDGTERSVLLGS 511
+ AN G+E + L+ +
Sbjct: 667 VYGANKFTGSEHATLVNN 684
>D16532-1|BAA03969.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 82.2 bits (194), Expect = 1e-15
Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 1/126 (0%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQF-LNTGIISPEGLAIDWSARNIFWTD 307
V++ D + K++W D+ I A D + + +P +A+DW + I+WTD
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ TI VA LD RK LF+ ++ P IAV P G ++W+DW KIE A M+G
Sbjct: 532 AASKTISVATLDGTKRKFLFN-SDLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGF 589
Query: 488 ERSVLL 505
+R L+
Sbjct: 590 DRRPLV 595
Score = 55.2 bits (127), Expect = 1e-07
Identities = 38/138 (27%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Frame = +2
Query: 107 NSGISQVAVSVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWS 283
NS + + A S++VD SG +YW D I++AG +G + + I P G+ +D
Sbjct: 552 NSDLREPA-SIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
Query: 284 ARNIFWTDSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
++W DSK + +L+ + R+ VL S++ +++P + + R ++W D N
Sbjct: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDR--VYWID--GENEA 666
Query: 461 IEWAN-MDGTERSVLLGS 511
+ AN G+E + L+ +
Sbjct: 667 VYGANKFTGSELATLVNN 684
>D16494-1|BAA03946.1| 845|Homo sapiens very low density lipoprotein
receptor protein.
Length = 845
Score = 82.2 bits (194), Expect = 1e-15
Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 1/126 (0%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQF-LNTGIISPEGLAIDWSARNIFWTD 307
V++ D + K++W D+ I A D + + +P +A+DW + I+WTD
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ TI VA LD RK LF+ ++ P IAV P G ++W+DW KIE A M+G
Sbjct: 532 AASKTISVATLDGTKRKFLFN-SDLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGF 589
Query: 488 ERSVLL 505
+R L+
Sbjct: 590 DRRPLV 595
Score = 55.2 bits (127), Expect = 1e-07
Identities = 38/138 (27%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Frame = +2
Query: 107 NSGISQVAVSVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWS 283
NS + + A S++VD SG +YW D I++AG +G + + I P G+ +D
Sbjct: 552 NSDLREPA-SIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
Query: 284 ARNIFWTDSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
++W DSK + +L+ + R+ VL S++ +++P + + R ++W D N
Sbjct: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDR--VYWID--GENEA 666
Query: 461 IEWAN-MDGTERSVLLGS 511
+ AN G+E + L+ +
Sbjct: 667 VYGANKFTGSELATLVNN 684
>D16493-1|BAA03945.1| 873|Homo sapiens very low density lipoprotein
receptor protein.
Length = 873
Score = 82.2 bits (194), Expect = 1e-15
Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 1/126 (0%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQF-LNTGIISPEGLAIDWSARNIFWTD 307
V++ D + K++W D+ I A D + + +P +A+DW + I+WTD
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ TI VA LD RK LF+ ++ P IAV P G ++W+DW KIE A M+G
Sbjct: 532 AASKTISVATLDGTKRKFLFN-SDLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGF 589
Query: 488 ERSVLL 505
+R L+
Sbjct: 590 DRRPLV 595
Score = 55.2 bits (127), Expect = 1e-07
Identities = 38/138 (27%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Frame = +2
Query: 107 NSGISQVAVSVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWS 283
NS + + A S++VD SG +YW D I++AG +G + + I P G+ +D
Sbjct: 552 NSDLREPA-SIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
Query: 284 ARNIFWTDSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
++W DSK + +L+ + R+ VL S++ +++P + + R ++W D N
Sbjct: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDR--VYWID--GENEA 666
Query: 461 IEWAN-MDGTERSVLLGS 511
+ AN G+E + L+ +
Sbjct: 667 VYGANKFTGSELATLVNN 684
>DQ067198-1|AAY46157.1| 873|Homo sapiens very low density
lipoprotein receptor protein.
Length = 873
Score = 82.2 bits (194), Expect = 1e-15
Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 1/126 (0%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQF-LNTGIISPEGLAIDWSARNIFWTD 307
V++ D + K++W D+ I A D + + +P +A+DW + I+WTD
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ TI VA LD RK LF+ ++ P IAV P G ++W+DW KIE A M+G
Sbjct: 532 AASKTISVATLDGTKRKFLFN-SDLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGF 589
Query: 488 ERSVLL 505
+R L+
Sbjct: 590 DRRPLV 595
Score = 55.2 bits (127), Expect = 1e-07
Identities = 38/138 (27%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Frame = +2
Query: 107 NSGISQVAVSVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWS 283
NS + + A S++VD SG +YW D I++AG +G + + I P G+ +D
Sbjct: 552 NSDLREPA-SIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
Query: 284 ARNIFWTDSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
++W DSK + +L+ + R+ VL S++ +++P + + R ++W D N
Sbjct: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDR--VYWID--GENEA 666
Query: 461 IEWAN-MDGTERSVLLGS 511
+ AN G+E + L+ +
Sbjct: 667 VYGANKFTGSELATLVNN 684
>BC142653-1|AAI42654.1| 845|Homo sapiens very low density
lipoprotein receptor protein.
Length = 845
Score = 82.2 bits (194), Expect = 1e-15
Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 1/126 (0%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQF-LNTGIISPEGLAIDWSARNIFWTD 307
V++ D + K++W D+ I A D + + +P +A+DW + I+WTD
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ TI VA LD RK LF+ ++ P IAV P G ++W+DW KIE A M+G
Sbjct: 532 AASKTISVATLDGTKRKFLFN-SDLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGF 589
Query: 488 ERSVLL 505
+R L+
Sbjct: 590 DRRPLV 595
Score = 55.2 bits (127), Expect = 1e-07
Identities = 38/138 (27%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Frame = +2
Query: 107 NSGISQVAVSVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWS 283
NS + + A S++VD SG +YW D I++AG +G + + I P G+ +D
Sbjct: 552 NSDLREPA-SIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
Query: 284 ARNIFWTDSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
++W DSK + +L+ + R+ VL S++ +++P + + R ++W D N
Sbjct: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDR--VYWID--GENEA 666
Query: 461 IEWAN-MDGTERSVLLGS 511
+ AN G+E + L+ +
Sbjct: 667 VYGANKFTGSELATLVNN 684
>AL450467-4|CAH72453.1| 752|Homo sapiens very low density
lipoprotein receptor protein.
Length = 752
Score = 82.2 bits (194), Expect = 1e-15
Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 1/126 (0%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQF-LNTGIISPEGLAIDWSARNIFWTD 307
V++ D + K++W D+ I A D + + +P +A+DW + I+WTD
Sbjct: 351 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 410
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ TI VA LD RK LF+ ++ P IAV P G ++W+DW KIE A M+G
Sbjct: 411 AASKTISVATLDGTKRKFLFN-SDLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGF 468
Query: 488 ERSVLL 505
+R L+
Sbjct: 469 DRRPLV 474
Score = 55.2 bits (127), Expect = 1e-07
Identities = 38/138 (27%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Frame = +2
Query: 107 NSGISQVAVSVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWS 283
NS + + A S++VD SG +YW D I++AG +G + + I P G+ +D
Sbjct: 431 NSDLREPA-SIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 489
Query: 284 ARNIFWTDSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
++W DSK + +L+ + R+ VL S++ +++P + + R ++W D N
Sbjct: 490 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDR--VYWID--GENEA 545
Query: 461 IEWAN-MDGTERSVLLGS 511
+ AN G+E + L+ +
Sbjct: 546 VYGANKFTGSELATLVNN 563
>AL450467-3|CAH72455.1| 845|Homo sapiens very low density
lipoprotein receptor protein.
Length = 845
Score = 82.2 bits (194), Expect = 1e-15
Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 1/126 (0%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQF-LNTGIISPEGLAIDWSARNIFWTD 307
V++ D + K++W D+ I A D + + +P +A+DW + I+WTD
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ TI VA LD RK LF+ ++ P IAV P G ++W+DW KIE A M+G
Sbjct: 532 AASKTISVATLDGTKRKFLFN-SDLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGF 589
Query: 488 ERSVLL 505
+R L+
Sbjct: 590 DRRPLV 595
Score = 55.2 bits (127), Expect = 1e-07
Identities = 38/138 (27%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Frame = +2
Query: 107 NSGISQVAVSVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWS 283
NS + + A S++VD SG +YW D I++AG +G + + I P G+ +D
Sbjct: 552 NSDLREPA-SIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
Query: 284 ARNIFWTDSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
++W DSK + +L+ + R+ VL S++ +++P + + R ++W D N
Sbjct: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDR--VYWID--GENEA 666
Query: 461 IEWAN-MDGTERSVLLGS 511
+ AN G+E + L+ +
Sbjct: 667 VYGANKFTGSELATLVNN 684
>AL450467-2|CAH72454.1| 873|Homo sapiens very low density
lipoprotein receptor protein.
Length = 873
Score = 82.2 bits (194), Expect = 1e-15
Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 1/126 (0%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQF-LNTGIISPEGLAIDWSARNIFWTD 307
V++ D + K++W D+ I A D + + +P +A+DW + I+WTD
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ TI VA LD RK LF+ ++ P IAV P G ++W+DW KIE A M+G
Sbjct: 532 AASKTISVATLDGTKRKFLFN-SDLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGF 589
Query: 488 ERSVLL 505
+R L+
Sbjct: 590 DRRPLV 595
Score = 55.2 bits (127), Expect = 1e-07
Identities = 38/138 (27%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Frame = +2
Query: 107 NSGISQVAVSVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWS 283
NS + + A S++VD SG +YW D I++AG +G + + I P G+ +D
Sbjct: 552 NSDLREPA-SIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
Query: 284 ARNIFWTDSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
++W DSK + +L+ + R+ VL S++ +++P + + R ++W D N
Sbjct: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDR--VYWID--GENEA 666
Query: 461 IEWAN-MDGTERSVLLGS 511
+ AN G+E + L+ +
Sbjct: 667 VYGANKFTGSELATLVNN 684
>AK092381-1|BAC03874.1| 752|Homo sapiens protein ( Homo sapiens
cDNA FLJ35062 fis, clone OCBBF2019195, highly similar to
VERY LOW-DENSITY LIPOPROTEIN RECEPTOR PRECURSOR. ).
Length = 752
Score = 82.2 bits (194), Expect = 1e-15
Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 1/126 (0%)
Frame = +2
Query: 131 VSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQF-LNTGIISPEGLAIDWSARNIFWTD 307
V++ D + K++W D+ I A D + + +P +A+DW + I+WTD
Sbjct: 351 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 410
Query: 308 SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
+ TI VA LD RK LF+ ++ P IAV P G ++W+DW KIE A M+G
Sbjct: 411 AASKTISVATLDGTKRKFLFN-SDLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGF 468
Query: 488 ERSVLL 505
+R L+
Sbjct: 469 DRRPLV 474
Score = 55.2 bits (127), Expect = 1e-07
Identities = 38/138 (27%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Frame = +2
Query: 107 NSGISQVAVSVSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWS 283
NS + + A S++VD SG +YW D I++AG +G + + I P G+ +D
Sbjct: 431 NSDLREPA-SIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 489
Query: 284 ARNIFWTDSKKLTIEVANLDTKVRK-VLFSVQNISNPRGIAVHPQRGKIFWTDWNRSNPK 460
++W DSK + +L+ + R+ VL S++ +++P + + R ++W D N
Sbjct: 490 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDR--VYWID--GENEA 545
Query: 461 IEWAN-MDGTERSVLLGS 511
+ AN G+E + L+ +
Sbjct: 546 VYGANKFTGSELATLVNN 563
>Y08110-1|CAA69325.1| 2214|Homo sapiens mosaic protein LR11 protein.
Length = 2214
Score = 81.0 bits (191), Expect = 2e-15
Identities = 48/154 (31%), Positives = 82/154 (53%), Gaps = 1/154 (0%)
Frame = +2
Query: 29 FLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAG 208
F++ + SIYR E P+ +G+ + AV++ D +YW D+ + I+R
Sbjct: 760 FILYAVRKSIYRYDLASGATE-QLPL-TGL-RAAVALDFDYEHNCLYWSDLALDVIQRLC 816
Query: 209 YDGSEFEQ-FLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNIS 385
+GS ++ +N+G+ + E LA + ++ ++W D+ IEVAN D R + + +
Sbjct: 817 LNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLD 876
Query: 386 NPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
PR + + PQ G +FWTDW P I +NMDG+
Sbjct: 877 RPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGS 910
Score = 46.8 bits (106), Expect = 5e-05
Identities = 28/93 (30%), Positives = 49/93 (52%)
Frame = +2
Query: 170 WGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTK 349
WGD+ I R+ DGS ++ + P G+++D + I+WTD+ IE +
Sbjct: 895 WGDL-KPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQ 951
Query: 350 VRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
R V+ + N+ +P IAV + +I+W DW++
Sbjct: 952 QRSVI--LDNLPHPYAIAVF--KNEIYWDDWSQ 980
>U60975-1|AAC50891.2| 2214|Homo sapiens gp250 precursor protein.
Length = 2214
Score = 81.0 bits (191), Expect = 2e-15
Identities = 48/154 (31%), Positives = 82/154 (53%), Gaps = 1/154 (0%)
Frame = +2
Query: 29 FLVTSDGTSIYRVPFKYSPREFATPINSGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAG 208
F++ + SIYR E P+ +G+ + AV++ D +YW D+ + I+R
Sbjct: 760 FILYAVRKSIYRYDLASGATE-QLPL-TGL-RAAVALDFDYEHNCLYWSDLALDVIQRLC 816
Query: 209 YDGSEFEQ-FLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNIS 385
+GS ++ +N+G+ + E LA + ++ ++W D+ IEVAN D R + + +
Sbjct: 817 LNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLD 876
Query: 386 NPRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGT 487
PR + + PQ G +FWTDW P I +NMDG+
Sbjct: 877 RPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGS 910
Score = 46.8 bits (106), Expect = 5e-05
Identities = 28/93 (30%), Positives = 49/93 (52%)
Frame = +2
Query: 170 WGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTK 349
WGD+ I R+ DGS ++ + P G+++D + I+WTD+ IE +
Sbjct: 895 WGDL-KPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQ 951
Query: 350 VRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
R V+ + N+ +P IAV + +I+W DW++
Sbjct: 952 QRSVI--LDNLPHPYAIAVF--KNEIYWDDWSQ 980
>AF283408-1|AAL38109.1| 1537|Homo sapiens candidate tumor suppressor
protein protein.
Length = 1537
Score = 75.8 bits (178), Expect = 9e-14
Identities = 45/139 (32%), Positives = 75/139 (53%), Gaps = 3/139 (2%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSNN---IKRAGYDGSEFEQFLNTGIISPEGL 268
T + G++ V +++ D IYW D N I R +GS+ + NT + P L
Sbjct: 360 TLLKQGLNNV-IAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNAL 416
Query: 269 AIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
A+DW +N++W+D++K IEV+ L+ +L S + + PR +++ PQ G ++W D
Sbjct: 417 AVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVS-KRLKFPRDLSLDPQAGYLYWIDC-C 474
Query: 449 SNPKIEWANMDGTERSVLL 505
P I MDGT +SV++
Sbjct: 475 EYPHIGRVGMDGTNQSVVI 493
Score = 49.6 bits (113), Expect = 7e-06
Identities = 34/102 (33%), Positives = 48/102 (47%), Gaps = 1/102 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
+S+D +G +YW D +I R G DG+ + T I P L ID+ R ++W D
Sbjct: 459 LSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADEN 518
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
IE +N+D R V N P IA+ I+WTD
Sbjct: 519 H--IEFSNMDGSHR---HKVPNQDIPGVIALTLFEDYIYWTD 555
Score = 46.8 bits (106), Expect = 5e-05
Identities = 35/108 (32%), Positives = 53/108 (49%), Gaps = 19/108 (17%)
Frame = +2
Query: 239 NTGIISPE-----GLAIDWSARNIFWTDSKKL------TIEVANLDTKVRKVLFSVQNIS 385
N+G+I PE +A+DW A NI+WTD ++ T +L + + N +
Sbjct: 1284 NSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCT 1343
Query: 386 N--------PRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
P IAV+P+RG ++WT + IE A MDGT R +L+
Sbjct: 1344 RLLTNMAGEPYAIAVNPKRGMMYWTVVG-DHSHIEEAAMDGTLRRILV 1390
Score = 40.7 bits (91), Expect = 0.003
Identities = 27/100 (27%), Positives = 53/100 (53%), Gaps = 1/100 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSNN-IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++V+ G +YW V ++ I+ A DG+ + + P GLA+D+ + I+W D
Sbjct: 1355 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD- 1413
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIF 430
E++ + + + SV ++S+ +G+ +HP R IF
Sbjct: 1414 ----FELSIIGSVLYDGSNSVVSVSSKQGL-LHPHRIDIF 1448
Score = 33.5 bits (73), Expect = 0.46
Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 1/66 (1%)
Frame = +2
Query: 257 PEGLAIDWSARNIFWTD-SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFW 433
P +A++ ++WT IE A +D +R++L +N+ P G+AV +I+W
Sbjct: 1353 PYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQ-KNLQRPTGLAVDYFSERIYW 1411
Query: 434 TDWNRS 451
D+ S
Sbjct: 1412 ADFELS 1417
Score = 29.1 bits (62), Expect = 9.9
Identities = 14/33 (42%), Positives = 18/33 (54%)
Frame = +2
Query: 122 QVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGS 220
Q ++VD FS +IYW D + I YDGS
Sbjct: 1395 QRPTGLAVDYFSERIYWADFELSIIGSVLYDGS 1427
>AB209707-1|BAD92944.1| 1720|Homo sapiens low density
lipoprotein-related protein 1B variant protein.
Length = 1720
Score = 75.8 bits (178), Expect = 9e-14
Identities = 45/139 (32%), Positives = 75/139 (53%), Gaps = 3/139 (2%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSNN---IKRAGYDGSEFEQFLNTGIISPEGL 268
T + G++ V +++ D IYW D N I R +GS+ + NT + P L
Sbjct: 157 TLLKQGLNNV-IAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNAL 213
Query: 269 AIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTDWNR 448
A+DW +N++W+D++K IEV+ L+ +L S + + PR +++ PQ G ++W D
Sbjct: 214 AVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVS-KRLKFPRDLSLDPQAGYLYWIDC-C 271
Query: 449 SNPKIEWANMDGTERSVLL 505
P I MDGT +SV++
Sbjct: 272 EYPHIGRVGMDGTNQSVVI 290
Score = 49.6 bits (113), Expect = 7e-06
Identities = 34/102 (33%), Positives = 48/102 (47%), Gaps = 1/102 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
+S+D +G +YW D +I R G DG+ + T I P L ID+ R ++W D
Sbjct: 256 LSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADEN 315
Query: 314 KLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
IE +N+D R V N P IA+ I+WTD
Sbjct: 316 H--IEFSNMDGSHR---HKVPNQDIPGVIALTLFEDYIYWTD 352
Score = 46.8 bits (106), Expect = 5e-05
Identities = 35/108 (32%), Positives = 53/108 (49%), Gaps = 19/108 (17%)
Frame = +2
Query: 239 NTGIISPE-----GLAIDWSARNIFWTDSKKL------TIEVANLDTKVRKVLFSVQNIS 385
N+G+I PE +A+DW A NI+WTD ++ T +L + + N +
Sbjct: 1081 NSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCT 1140
Query: 386 N--------PRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
P IAV+P+RG ++WT + IE A MDGT R +L+
Sbjct: 1141 RLLTNMAGEPYAIAVNPKRGMMYWTVVG-DHSHIEEAAMDGTLRRILV 1187
Score = 40.7 bits (91), Expect = 0.003
Identities = 27/100 (27%), Positives = 53/100 (53%), Gaps = 1/100 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSNN-IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++V+ G +YW V ++ I+ A DG+ + + P GLA+D+ + I+W D
Sbjct: 1152 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD- 1210
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIF 430
E++ + + + SV ++S+ +G+ +HP R IF
Sbjct: 1211 ----FELSIIGSVLYDGSNSVVSVSSKQGL-LHPHRIDIF 1245
Score = 33.5 bits (73), Expect = 0.46
Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 1/66 (1%)
Frame = +2
Query: 257 PEGLAIDWSARNIFWTD-SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFW 433
P +A++ ++WT IE A +D +R++L +N+ P G+AV +I+W
Sbjct: 1150 PYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQ-KNLQRPTGLAVDYFSERIYW 1208
Query: 434 TDWNRS 451
D+ S
Sbjct: 1209 ADFELS 1214
Score = 29.1 bits (62), Expect = 9.9
Identities = 14/33 (42%), Positives = 18/33 (54%)
Frame = +2
Query: 122 QVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGS 220
Q ++VD FS +IYW D + I YDGS
Sbjct: 1192 QRPTGLAVDYFSERIYWADFELSIIGSVLYDGS 1224
>AC093039-1|AAX88911.1| 425|Homo sapiens unknown protein.
Length = 425
Score = 59.7 bits (138), Expect = 6e-09
Identities = 35/111 (31%), Positives = 60/111 (54%), Gaps = 3/111 (2%)
Frame = +2
Query: 98 TPINSGISQVAVSVSVDCFSGKIYWGDVVSNN---IKRAGYDGSEFEQFLNTGIISPEGL 268
T + G++ V +++ D IYW D N I R +GS+ + NT + P L
Sbjct: 319 TLLKQGLNNV-IAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNAL 375
Query: 269 AIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRG 421
A+DW +N++W+D++K IEV+ L+ +L S + + PR +++ PQ G
Sbjct: 376 AVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVS-KRLKFPRDLSLDPQAG 425
>BC021204-1|AAH21204.1| 439|Homo sapiens LRP1 protein protein.
Length = 439
Score = 57.6 bits (133), Expect = 2e-08
Identities = 31/84 (36%), Positives = 48/84 (57%)
Frame = +2
Query: 260 EGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
E +AIDW N ++ D I V N + L ++ + NP+GIA+ P GK+F+TD
Sbjct: 283 EQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLE-LYNPKGIALDPAMGKVFFTD 341
Query: 440 WNRSNPKIEWANMDGTERSVLLGS 511
+ + PK+E +MDG R+ L+ S
Sbjct: 342 YGQI-PKVERCDMDGQNRTKLVDS 364
Score = 41.1 bits (92), Expect = 0.002
Identities = 24/102 (23%), Positives = 50/102 (49%), Gaps = 1/102 (0%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKK 316
+++D +G Y+ D + + I +G L+ + +P+G+A+D + +F+TD +
Sbjct: 285 MAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQ 344
Query: 317 L-TIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
+ +E ++D + R L I P GI + ++W D
Sbjct: 345 IPKVERCDMDGQNRTKLVD-SKIVFPHGITLDLVSRLVYWAD 385
Score = 40.7 bits (91), Expect = 0.003
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 1/77 (1%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVS-NNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSK 313
+++D GK+++ D ++R DG + +++ I+ P G+ +D +R ++W D+
Sbjct: 328 IALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAY 387
Query: 314 KLTIEVANLDTKVRKVL 364
IEV + + K R+ +
Sbjct: 388 LDYIEVVDYEGKGRQTI 404
>AC068195-1|AAX93243.1| 1126|Homo sapiens unknown protein.
Length = 1126
Score = 46.8 bits (106), Expect = 5e-05
Identities = 35/108 (32%), Positives = 53/108 (49%), Gaps = 19/108 (17%)
Frame = +2
Query: 239 NTGIISPE-----GLAIDWSARNIFWTDSKKL------TIEVANLDTKVRKVLFSVQNIS 385
N+G+I PE +A+DW A NI+WTD ++ T +L + + N +
Sbjct: 818 NSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCT 877
Query: 386 N--------PRGIAVHPQRGKIFWTDWNRSNPKIEWANMDGTERSVLL 505
P IAV+P+RG ++WT + IE A MDGT R +L+
Sbjct: 878 RLLTNMAGEPYAIAVNPKRGMMYWTVVG-DHSHIEEAAMDGTLRRILV 924
Score = 45.2 bits (102), Expect = 1e-04
Identities = 31/93 (33%), Positives = 42/93 (45%), Gaps = 1/93 (1%)
Frame = +2
Query: 164 IYWGDVVSN-NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANL 340
+YW D +I R G DG+ + T I P L ID+ R ++W D IE +N+
Sbjct: 2 LYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENH--IEFSNM 59
Query: 341 DTKVRKVLFSVQNISNPRGIAVHPQRGKIFWTD 439
D R V N P IA+ I+WTD
Sbjct: 60 DGSHR---HKVPNQDIPGVIALTLFEDYIYWTD 89
Score = 40.7 bits (91), Expect = 0.003
Identities = 27/100 (27%), Positives = 53/100 (53%), Gaps = 1/100 (1%)
Frame = +2
Query: 134 SVSVDCFSGKIYWGDVVSNN-IKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDS 310
+++V+ G +YW V ++ I+ A DG+ + + P GLA+D+ + I+W D
Sbjct: 889 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWAD- 947
Query: 311 KKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIF 430
E++ + + + SV ++S+ +G+ +HP R IF
Sbjct: 948 ----FELSIIGSVLYDGSNSVVSVSSKQGL-LHPHRIDIF 982
Score = 33.5 bits (73), Expect = 0.46
Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 1/66 (1%)
Frame = +2
Query: 257 PEGLAIDWSARNIFWTD-SKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRGKIFW 433
P +A++ ++WT IE A +D +R++L +N+ P G+AV +I+W
Sbjct: 887 PYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQ-KNLQRPTGLAVDYFSERIYW 945
Query: 434 TDWNRS 451
D+ S
Sbjct: 946 ADFELS 951
Score = 29.1 bits (62), Expect = 9.9
Identities = 14/33 (42%), Positives = 18/33 (54%)
Frame = +2
Query: 122 QVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGS 220
Q ++VD FS +IYW D + I YDGS
Sbjct: 929 QRPTGLAVDYFSERIYWADFELSIIGSVLYDGS 961
>AC108036-1|AAX93208.1| 449|Homo sapiens unknown protein.
Length = 449
Score = 42.7 bits (96), Expect = 8e-04
Identities = 25/86 (29%), Positives = 41/86 (47%)
Frame = +2
Query: 191 NIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFS 370
+I R+ G + ++T I++P GL ID+ A ++++D IE D R V+
Sbjct: 76 SIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVK 135
Query: 371 VQNISNPRGIAVHPQRGKIFWTDWNR 448
+AV+ IFW+DW R
Sbjct: 136 -SGPGTFLSLAVYD--NYIFWSDWGR 158
Score = 39.9 bits (89), Expect = 0.005
Identities = 23/91 (25%), Positives = 45/91 (49%), Gaps = 5/91 (5%)
Frame = +2
Query: 254 SPEGLAIDWSARNIFWTDSKKLTIEVANLD-TKV----RKVLFSVQNISNPRGIAVHPQR 418
S EGLA + ++WT S +I +D T+ R+ + ++ +P +A+ +
Sbjct: 3 SVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQ 62
Query: 419 GKIFWTDWNRSNPKIEWANMDGTERSVLLGS 511
+FWT+WN +P I + + G V++ +
Sbjct: 63 NLMFWTNWNEQHPSIMRSTLTGKNAQVVVST 93
Score = 29.1 bits (62), Expect = 9.9
Identities = 17/57 (29%), Positives = 30/57 (52%)
Frame = +2
Query: 137 VSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTD 307
+++D + K+Y+ D I+R YDGS+ + +G + LA+ IFW+D
Sbjct: 101 LTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAV--YDNYIFWSD 155
>AC068287-1|AAY24318.1| 223|Homo sapiens unknown protein.
Length = 223
Score = 35.1 bits (77), Expect = 0.15
Identities = 19/52 (36%), Positives = 28/52 (53%)
Frame = +2
Query: 266 LAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQNISNPRGIAVHPQRG 421
+AIDW RN+++ D I V N + V L ++ + NP+ IAV P G
Sbjct: 173 MAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLE-LHNPKAIAVDPIAG 223
>AB210026-1|BAE06108.1| 2018|Homo sapiens MYH10 variant protein
protein.
Length = 2018
Score = 30.3 bits (65), Expect = 4.3
Identities = 15/61 (24%), Positives = 28/61 (45%)
Frame = +2
Query: 158 GKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVAN 337
G +W V +R G + E F++ +I DW+A+ + W S++ E A+
Sbjct: 2 GNCFW-IVPFTMAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAAS 60
Query: 338 L 340
+
Sbjct: 61 I 61
>AB067384-1|BAC02419.1| 124|Homo sapiens immunoglobulin heavy chain
VHDJ region protein.
Length = 124
Score = 30.3 bits (65), Expect = 4.3
Identities = 21/95 (22%), Positives = 48/95 (50%), Gaps = 2/95 (2%)
Frame = +2
Query: 110 SGISQVAVSVSVDCFSGKIYWGDVVSNNIKRAGYDGSEFEQFLNTGIISPEGLAIDWSAR 289
S + + SV V C + + + + V N +++A G E+ ++NT +P A ++ R
Sbjct: 9 SELKKPGASVKVSCKASEYTFTNYVMNWVRQAPGQGLEWMGWINTNTGNPR-YAQGFTGR 67
Query: 290 NIFWTDSKKLT--IEVANLDTKVRKVLFSVQNISN 388
+F D+ T +++++L+ + V + + S+
Sbjct: 68 FVFSLDTSVSTAYLQISSLEAEDTAVYYCARTASS 102
>U34304-1|AAA84880.1| 81|Homo sapiens nonmuscle myosin heavy chain
IIB protein.
Length = 81
Score = 29.5 bits (63), Expect = 7.5
Identities = 12/48 (25%), Positives = 24/48 (50%)
Frame = +2
Query: 197 KRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANL 340
+R G + E F++ +I DW+A+ + W S++ E A++
Sbjct: 3 QRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASI 50
>M69181-1|AAA99177.1| 1976|Homo sapiens non-muscle myosin B protein.
Length = 1976
Score = 29.5 bits (63), Expect = 7.5
Identities = 12/48 (25%), Positives = 24/48 (50%)
Frame = +2
Query: 197 KRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANL 340
+R G + E F++ +I DW+A+ + W S++ E A++
Sbjct: 3 QRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASI 50
>BC117691-1|AAI17692.1| 1976|Homo sapiens myosin, heavy chain 10,
non-muscle protein.
Length = 1976
Score = 29.5 bits (63), Expect = 7.5
Identities = 12/48 (25%), Positives = 24/48 (50%)
Frame = +2
Query: 197 KRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANL 340
+R G + E F++ +I DW+A+ + W S++ E A++
Sbjct: 3 QRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASI 50
>BC117690-1|AAI17691.1| 1976|Homo sapiens myosin, heavy chain 10,
non-muscle protein.
Length = 1976
Score = 29.5 bits (63), Expect = 7.5
Identities = 12/48 (25%), Positives = 24/48 (50%)
Frame = +2
Query: 197 KRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANL 340
+R G + E F++ +I DW+A+ + W S++ E A++
Sbjct: 3 QRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASI 50
>M95724-1|AAA51974.1| 943|Homo sapiens centromere autoantigen C
protein.
Length = 943
Score = 29.1 bits (62), Expect = 9.9
Identities = 21/76 (27%), Positives = 34/76 (44%)
Frame = +2
Query: 197 KRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQ 376
+R Y G F+ +G++SP+ ++ A+ +KK + LD RK V
Sbjct: 754 ERIDYQGRPSGGFVISGVLSPDTISSKRKAKENIGKVNKKSNKKRICLDNDERKTNLMV- 812
Query: 377 NISNPRGIAVHPQRGK 424
N+ P G + P R K
Sbjct: 813 NLGIPLGDPLQPTRVK 828
>BC041117-1|AAH41117.1| 943|Homo sapiens centromere protein C 1
protein.
Length = 943
Score = 29.1 bits (62), Expect = 9.9
Identities = 21/76 (27%), Positives = 34/76 (44%)
Frame = +2
Query: 197 KRAGYDGSEFEQFLNTGIISPEGLAIDWSARNIFWTDSKKLTIEVANLDTKVRKVLFSVQ 376
+R Y G F+ +G++SP+ ++ A+ +KK + LD RK V
Sbjct: 754 ERIDYQGRPSGGFVISGVLSPDTISSKRKAKENIGKVNKKSNKKRICLDNDERKTNLMV- 812
Query: 377 NISNPRGIAVHPQRGK 424
N+ P G + P R K
Sbjct: 813 NLGIPLGDPLQPTRVK 828
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 77,057,055
Number of Sequences: 237096
Number of extensions: 1653120
Number of successful extensions: 8286
Number of sequences better than 10.0: 94
Number of HSP's better than 10.0 without gapping: 7143
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7627
length of database: 76,859,062
effective HSP length: 85
effective length of database: 56,705,902
effective search space used: 4990119376
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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