Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= ovS312B07f
(521 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein. 188 1e-47
CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein. 188 1e-47
BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein pr... 188 1e-47
BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein. 188 1e-47
AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitr... 188 1e-47
AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein. 188 1e-47
BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenas... 186 3e-47
CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein. 185 1e-46
AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitra... 182 5e-46
DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenas... 173 2e-43
X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase... 160 3e-39
U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase ... 159 5e-39
BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenas... 159 5e-39
BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenas... 159 5e-39
AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenas... 159 5e-39
AF197566-1|AAG43470.1| 127|Homo sapiens NADP+-specific isocitra... 128 2e-29
>CR541695-1|CAG46496.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 188 bits (457), Expect = 1e-47
Identities = 88/113 (77%), Positives = 96/113 (84%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKTVEAEAAHGTVTRH+R YQ+G+ETSTNPIASIFAWTRGL HRAKLDNN L FA
Sbjct: 299 DGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANA 358
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLKVALGQ 182
LE+V IETIE+G MTKDLA CIKG+ NV+RSDY TFEFMDKL ENLK+ L Q
Sbjct: 359 LEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQ 411
>CR536499-1|CAG38738.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 188 bits (457), Expect = 1e-47
Identities = 88/113 (77%), Positives = 96/113 (84%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKTVEAEAAHGTVTRH+R YQ+G+ETSTNPIASIFAWTRGL HRAKLDNN L FA
Sbjct: 299 DGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANA 358
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLKVALGQ 182
LE+V IETIE+G MTKDLA CIKG+ NV+RSDY TFEFMDKL ENLK+ L Q
Sbjct: 359 LEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQ 411
>BX537411-1|CAD97653.1| 414|Homo sapiens hypothetical protein
protein.
Length = 414
Score = 188 bits (457), Expect = 1e-47
Identities = 88/113 (77%), Positives = 96/113 (84%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKTVEAEAAHGTVTRH+R YQ+G+ETSTNPIASIFAWTRGL HRAKLDNN L FA
Sbjct: 299 DGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANA 358
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLKVALGQ 182
LE+V IETIE+G MTKDLA CIKG+ NV+RSDY TFEFMDKL ENLK+ L Q
Sbjct: 359 LEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQ 411
>BC012846-1|AAH12846.1| 414|Homo sapiens IDH1 protein protein.
Length = 414
Score = 188 bits (457), Expect = 1e-47
Identities = 88/113 (77%), Positives = 96/113 (84%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKTVEAEAAHGTVTRH+R YQ+G+ETSTNPIASIFAWTRGL HRAKLDNN L FA
Sbjct: 299 DGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANA 358
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLKVALGQ 182
LE+V IETIE+G MTKDLA CIKG+ NV+RSDY TFEFMDKL ENLK+ L Q
Sbjct: 359 LEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQ 411
>AF113917-1|AAD29284.1| 414|Homo sapiens NADP+-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 188 bits (457), Expect = 1e-47
Identities = 88/113 (77%), Positives = 96/113 (84%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKTVEAEAAHGTVTRH+R YQ+G+ETSTNPIASIFAWTRGL HRAKLDNN L FA
Sbjct: 299 DGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANA 358
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLKVALGQ 182
LE+V IETIE+G MTKDLA CIKG+ NV+RSDY TFEFMDKL ENLK+ L Q
Sbjct: 359 LEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQ 411
>AC016697-3|AAX93221.1| 414|Homo sapiens unknown protein.
Length = 414
Score = 188 bits (457), Expect = 1e-47
Identities = 88/113 (77%), Positives = 96/113 (84%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKTVEAEAAHGTVTRH+R YQ+G+ETSTNPIASIFAWTRGL HRAKLDNN L FA
Sbjct: 299 DGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANA 358
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLKVALGQ 182
LE+V IETIE+G MTKDLA CIKG+ NV+RSDY TFEFMDKL ENLK+ L Q
Sbjct: 359 LEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQ 411
>BC093020-1|AAH93020.1| 414|Homo sapiens isocitrate dehydrogenase 1
(NADP+), soluble protein.
Length = 414
Score = 186 bits (454), Expect = 3e-47
Identities = 87/113 (76%), Positives = 96/113 (84%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKTVEAE+AHGTVTRH+R YQ+G+ETSTNPIASIFAWTRGL HRAKLDNN L FA
Sbjct: 299 DGKTVEAESAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANA 358
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLKVALGQ 182
LE+V IETIE+G MTKDLA CIKG+ NV+RSDY TFEFMDKL ENLK+ L Q
Sbjct: 359 LEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQ 411
>CR533522-1|CAG38553.1| 414|Homo sapiens IDH1 protein.
Length = 414
Score = 185 bits (450), Expect = 1e-46
Identities = 87/113 (76%), Positives = 95/113 (84%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKTVEAEAAHGTVTRH+R YQ+G+ETSTNPIASIFAWTRGL HRAKLDNN L FA
Sbjct: 299 DGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANA 358
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLKVALGQ 182
LE+V IETIE+G MTK LA CIKG+ NV+RSDY TFEFMDKL ENLK+ L Q
Sbjct: 359 LEEVSIETIEAGFMTKGLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQ 411
>AF020038-1|AAD02918.1| 414|Homo sapiens NADP-dependent isocitrate
dehydrogenase protein.
Length = 414
Score = 182 bits (444), Expect = 5e-46
Identities = 86/113 (76%), Positives = 95/113 (84%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKTVEAEAAHGTVTRH+R YQ+G+ETSTN IASIFAWTRGL HRAKLDNN L FA
Sbjct: 299 DGKTVEAEAAHGTVTRHYRMYQKGQETSTNLIASIFAWTRGLAHRAKLDNNKELAFFANA 358
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDKLAENLKVALGQ 182
LE+V IETIE+G MTKDLA CI+G+ NV+RSDY TFEFMDKL ENLK+ L Q
Sbjct: 359 LEEVSIETIEAGFMTKDLAACIRGLPNVQRSDYLNTFEFMDKLGENLKIKLAQ 411
>DQ403082-1|ABD77215.1| 371|Homo sapiens isocitrate dehydrogenase 1
protein.
Length = 371
Score = 173 bits (422), Expect = 2e-43
Identities = 81/102 (79%), Positives = 88/102 (86%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKTVEAEAAHGTVTRH+R YQ+G+ETSTNPIASIFAWTRGL HRAKLDNN L FA
Sbjct: 270 DGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANA 329
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYYETFEFMDK 215
LE+V IETIE+G MTKDLA CIKG+ NV+RSDY TFEFMDK
Sbjct: 330 LEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDK 371
>X69433-1|CAA49208.1| 452|Homo sapiens isocitrate dehydrogenase
(NADP+) protein.
Length = 452
Score = 160 bits (388), Expect = 3e-39
Identities = 74/114 (64%), Positives = 92/114 (80%), Gaps = 1/114 (0%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKT+EAEAAHGTVTRH+R +Q+G+ TSTNPIASIFAWTRGL HR KLD N L FA+
Sbjct: 338 DGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQM 397
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYY-ETFEFMDKLAENLKVALGQ 182
LEKVC+ET+ESG MTKDLA CI G++NVK ++++ T +F+D + NL ALG+
Sbjct: 398 LEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTMDFLDTIKSNLDRALGR 451
>U52144-1|AAC50455.1| 419|Homo sapiens isocitrate dehydrogenase
protein.
Length = 419
Score = 159 bits (386), Expect = 5e-39
Identities = 74/114 (64%), Positives = 92/114 (80%), Gaps = 1/114 (0%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKT+EAEAAHGTVTRH+R +Q+G+ TSTNPIASIFAWTRGL HR KLD N L FA+
Sbjct: 305 DGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQM 364
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYY-ETFEFMDKLAENLKVALGQ 182
LEKVC+ET+ESG MTKDLA CI G++NVK ++++ T +F+D + NL ALG+
Sbjct: 365 LEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGR 418
>BC071828-1|AAH71828.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 159 bits (386), Expect = 5e-39
Identities = 74/114 (64%), Positives = 92/114 (80%), Gaps = 1/114 (0%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKT+EAEAAHGTVTRH+R +Q+G+ TSTNPIASIFAWTRGL HR KLD N L FA+
Sbjct: 338 DGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQM 397
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYY-ETFEFMDKLAENLKVALGQ 182
LEKVC+ET+ESG MTKDLA CI G++NVK ++++ T +F+D + NL ALG+
Sbjct: 398 LEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGR 451
>BC009244-1|AAH09244.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial protein.
Length = 452
Score = 159 bits (386), Expect = 5e-39
Identities = 74/114 (64%), Positives = 92/114 (80%), Gaps = 1/114 (0%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKT+EAEAAHGTVTRH+R +Q+G+ TSTNPIASIFAWTRGL HR KLD N L FA+
Sbjct: 338 DGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQM 397
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYY-ETFEFMDKLAENLKVALGQ 182
LEKVC+ET+ESG MTKDLA CI G++NVK ++++ T +F+D + NL ALG+
Sbjct: 398 LEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGR 451
>AK222916-1|BAD96636.1| 452|Homo sapiens isocitrate dehydrogenase 2
(NADP+), mitochondrial precursor variant protein.
Length = 452
Score = 159 bits (386), Expect = 5e-39
Identities = 74/114 (64%), Positives = 92/114 (80%), Gaps = 1/114 (0%)
Frame = -2
Query: 520 DGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAET 341
DGKT+EAEAAHGTVTRH+R +Q+G+ TSTNPIASIFAWTRGL HR KLD N L FA+
Sbjct: 338 DGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQM 397
Query: 340 LEKVCIETIESGIMTKDLAICIKGMNNVKRSDYY-ETFEFMDKLAENLKVALGQ 182
LEKVC+ET+ESG MTKDLA CI G++NVK ++++ T +F+D + NL ALG+
Sbjct: 398 LEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGR 451
>AF197566-1|AAG43470.1| 127|Homo sapiens NADP+-specific isocitrate
dehydrogenase protein.
Length = 127
Score = 128 bits (308), Expect = 2e-29
Identities = 61/89 (68%), Positives = 69/89 (77%)
Frame = -2
Query: 448 KETSTNPIASIFAWTRGLLHRAKLDNNDALKNFAETLEKVCIETIESGIMTKDLAICIKG 269
+E STNPIASIFAWTRGL RAK DNN L FA LE+VCIETIE+G MTKDLA CIKG
Sbjct: 1 QEISTNPIASIFAWTRGLALRAKTDNNKELAFFANALEEVCIETIEAGFMTKDLAACIKG 60
Query: 268 MNNVKRSDYYETFEFMDKLAENLKVALGQ 182
+ + + SDY TFEFM+KL ENLK+ L Q
Sbjct: 61 LPSAQCSDYLNTFEFMEKLGENLKIKLAQ 89
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 65,076,140
Number of Sequences: 237096
Number of extensions: 1191220
Number of successful extensions: 1825
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 1781
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1819
length of database: 76,859,062
effective HSP length: 85
effective length of database: 56,705,902
effective search space used: 4990119376
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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