Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= ovS303E01f
(521 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 247 1e-64
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 230 2e-59
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 194 1e-48
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 191 7e-48
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 175 4e-43
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 167 1e-40
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 165 5e-40
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 163 3e-39
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 163 3e-39
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 159 3e-38
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 144 1e-33
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 143 2e-33
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 142 4e-33
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 141 8e-33
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 136 3e-31
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 134 1e-30
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 132 5e-30
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 129 4e-29
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 126 3e-28
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 121 9e-27
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 120 2e-26
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 120 3e-26
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 118 1e-25
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 113 3e-24
UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 107 2e-22
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 103 2e-21
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 103 2e-21
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 103 2e-21
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 100 2e-20
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 100 2e-20
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 98 9e-20
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 97 3e-19
UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 96 4e-19
UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 95 7e-19
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 93 5e-18
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 92 8e-18
UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenas... 91 1e-17
UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5; T... 89 4e-17
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 89 6e-17
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 87 2e-16
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 85 7e-16
UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2; T... 85 9e-16
UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n... 84 2e-15
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 83 3e-15
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 83 3e-15
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 81 2e-14
UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2... 80 3e-14
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 79 8e-14
UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella ve... 79 8e-14
UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp - Pa... 78 1e-13
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 77 2e-13
UniRef50_O67480 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 77 2e-13
UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependen... 77 3e-13
UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5; E... 77 3e-13
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 73 3e-12
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 71 2e-11
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 69 9e-11
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 67 2e-10
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 67 3e-10
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 65 1e-09
UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|R... 64 2e-09
UniRef50_Q44471 Cluster: Probable tartrate dehydrogenase/decarbo... 64 2e-09
UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3; Proteobact... 63 4e-09
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 62 7e-09
UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50; ... 62 1e-08
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 61 2e-08
UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1; N... 60 2e-08
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 60 3e-08
UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;... 59 5e-08
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 56 4e-07
UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2; R... 56 4e-07
UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenas... 56 7e-07
UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyc... 54 2e-06
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 54 2e-06
UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila melanogaster|... 54 2e-06
UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|R... 54 3e-06
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 53 3e-06
UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 53 5e-06
UniRef50_Q8YCX4 Cluster: 3-isopropylmalate dehydrogenase; n=126;... 53 5e-06
UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7; A... 52 6e-06
UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 52 1e-05
UniRef50_Q8A6M0 Cluster: 3-isopropylmalate dehydrogenase; n=42; ... 51 1e-05
UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenas... 51 2e-05
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 51 2e-05
UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2; B... 50 2e-05
UniRef50_Q1IZK2 Cluster: 3-isopropylmalate dehydrogenase; n=3; B... 50 4e-05
UniRef50_Q03UM1 Cluster: 3-isopropylmalate dehydrogenase; n=2; L... 49 6e-05
UniRef50_Q05FQ8 Cluster: 3-isopropylmalate dehydrogenase; n=1; C... 49 7e-05
UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;... 48 1e-04
UniRef50_Q7VH33 Cluster: 3-isopropylmalate dehydrogenase; n=11; ... 48 2e-04
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 47 2e-04
UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 46 7e-04
UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella pneumophi... 45 0.001
UniRef50_Q300E7 Cluster: Isocitrate/isopropylmalate dehydrogenas... 45 0.001
UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1; ... 44 0.002
UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;... 44 0.002
UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1; V... 44 0.003
UniRef50_Q1IMD5 Cluster: 3-isopropylmalate dehydrogenase; n=1; A... 43 0.005
UniRef50_Q12545 Cluster: 3-isopropylmalate dehydrogenase; n=2; H... 42 0.009
UniRef50_P04173 Cluster: 3-isopropylmalate dehydrogenase; n=41; ... 41 0.015
UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72; ... 40 0.035
UniRef50_UPI00003C8595 Cluster: hypothetical protein Faci_030007... 39 0.060
UniRef50_Q3ZXI7 Cluster: 3-isopropylmalate dehydrogenase; n=66; ... 39 0.060
UniRef50_Q6B458 Cluster: 3-isopropylmalate dehydrogenase; n=30; ... 38 0.11
UniRef50_Q5A9E0 Cluster: Putative uncharacterized protein; n=1; ... 37 0.24
UniRef50_Q4P2R4 Cluster: Putative uncharacterized protein; n=1; ... 37 0.32
UniRef50_Q12592 Cluster: 3-isopropylmalate dehydrogenase; n=3; A... 37 0.32
UniRef50_A1WV93 Cluster: 3-isopropylmalate dehydrogenase; n=7; G... 36 0.43
UniRef50_A2E7S3 Cluster: Putative uncharacterized protein; n=1; ... 36 0.43
UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2; T... 36 0.43
UniRef50_O59395 Cluster: Putative uncharacterized protein PH1723... 36 0.43
UniRef50_A6GJ83 Cluster: Isocitrate dehydrogenase; n=1; Plesiocy... 36 0.56
UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4; B... 36 0.56
UniRef50_Q6AGK4 Cluster: Putative uncharacterized protein; n=1; ... 35 0.98
UniRef50_A0ZF75 Cluster: 3-isopropylmalate dehydrogenase; n=2; N... 35 0.98
UniRef50_P34738 Cluster: 3-isopropylmalate dehydrogenase; n=5; S... 35 0.98
UniRef50_Q9FBZ4 Cluster: Putative secreted peptidase; n=1; Strep... 35 1.3
UniRef50_A5FB87 Cluster: Von Willebrand factor, type A precursor... 34 1.7
UniRef50_A3DDD4 Cluster: Phage integrase; n=5; Clostridia|Rep: P... 34 1.7
UniRef50_A5DW24 Cluster: Putative uncharacterized protein; n=2; ... 34 1.7
UniRef50_A2TU03 Cluster: Ribonuclease HII; n=1; Dokdonia donghae... 34 2.3
UniRef50_A7SWW3 Cluster: Predicted protein; n=1; Nematostella ve... 34 2.3
UniRef50_Q2UNH1 Cluster: Predicted protein; n=2; Trichocomaceae|... 34 2.3
UniRef50_Q9RA19 Cluster: ORF10; n=1; Moritella marina|Rep: ORF10... 33 3.0
UniRef50_Q1QFN8 Cluster: Glycosidase, PH1107-related; n=2; Brady... 33 3.0
UniRef50_Q8WWQ4 Cluster: Mucin 5; n=5; Catarrhini|Rep: Mucin 5 -... 33 3.0
UniRef50_Q8D4B1 Cluster: Putative uncharacterized protein; n=2; ... 33 4.0
UniRef50_O59930 Cluster: 3-isopropylmalate dehydrogenase; n=3; D... 33 4.0
UniRef50_Q8VAX3 Cluster: Wsv250; n=2; Shrimp white spot syndrome... 32 6.9
UniRef50_UPI000023EC3A Cluster: hypothetical protein FG02409.1; ... 32 9.2
UniRef50_Q4RK60 Cluster: Chromosome 2 SCAF15032, whole genome sh... 32 9.2
UniRef50_Q92W49 Cluster: Putative chemotaxis methyltransferase p... 32 9.2
UniRef50_Q8R6G0 Cluster: Glycosyl transferase; n=1; Fusobacteriu... 32 9.2
UniRef50_Q2S2N6 Cluster: Possible 2-hydroxyhepta-2,4-diene-1,7-d... 32 9.2
UniRef50_Q1IN93 Cluster: Mg/Co/Ni transporter MgtE; n=1; Acidoba... 32 9.2
UniRef50_A6PEV1 Cluster: Binding-protein-dependent transport sys... 32 9.2
UniRef50_A5GBR8 Cluster: Putative uncharacterized protein precur... 32 9.2
UniRef50_Q4QHG5 Cluster: Putative uncharacterized protein; n=4; ... 32 9.2
UniRef50_Q4MYS8 Cluster: Putative uncharacterized protein; n=1; ... 32 9.2
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 247 bits (605), Expect = 1e-64
Identities = 118/153 (77%), Positives = 132/153 (86%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNL 181
IFEAA PI W+ VDVT V+G DG F IP + I+ ++ANK+GLKGPL TP+GKG+RSLNL
Sbjct: 46 IFEAADAPIAWDPVDVTPVKGRDGVFRIPSRCIELMHANKVGLKGPLETPIGKGHRSLNL 105
Query: 182 ALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLIT 361
A+RKEF LYANVRPC+SLEG KTLYDNVDVVTIRENTEGEYSGIEHEIV GVVQSIKLIT
Sbjct: 106 AVRKEFSLYANVRPCRSLEGHKTLYDNVDVVTIRENTEGEYSGIEHEIVPGVVQSIKLIT 165
Query: 362 EEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
E AS VA FAF++AR+N RK VTAVHKANIMR
Sbjct: 166 ETASRNVASFAFEYARQNGRKVVTAVHKANIMR 198
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 230 bits (562), Expect = 2e-59
Identities = 108/153 (70%), Positives = 129/153 (84%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNL 181
IF+AAK PI+WEE +VTA++GP GK+ IP +A +S++ NK+GLKGPL TP+ G+ S+NL
Sbjct: 53 IFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAAGHPSMNL 112
Query: 182 ALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLIT 361
LRK FDLYANVRPC S+EG KT Y +V++VTIRENTEGEYSGIEH IVDGVVQSIKLIT
Sbjct: 113 LLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLIT 172
Query: 362 EEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
E AS R+AEFAF++AR N R VTAVHKANIMR
Sbjct: 173 EGASKRIAEFAFEYARNNHRSNVTAVHKANIMR 205
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 194 bits (472), Expect = 1e-48
Identities = 91/153 (59%), Positives = 118/153 (77%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNL 181
+F AA V I+W+E V P + + SV NK+GLKGP+ TP+GKG+RSLNL
Sbjct: 65 VFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPIGKGHRSLNL 124
Query: 182 ALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLIT 361
LRKE +LYANVRPC SL G KT YD+VD++TIRENTEGEYSG+EH++V GVV+S+K+IT
Sbjct: 125 TLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGEYSGLEHQVVKGVVESLKIIT 184
Query: 362 EEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+AS RVAE+AF +A+ + RKKV+A+HKANIM+
Sbjct: 185 RKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQ 217
Score = 34.3 bits (75), Expect = 1.7
Identities = 12/18 (66%), Positives = 16/18 (88%)
Frame = +1
Query: 466 SDGLFLRCCRELATKYPD 519
+DGLFL+CC E+A KYP+
Sbjct: 219 TDGLFLQCCDEVAAKYPE 236
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 191 bits (466), Expect = 7e-48
Identities = 93/153 (60%), Positives = 112/153 (73%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNL 181
IF AA VPIEWE DV+ + +G IP A+ S+ N + LKGPL TP+GKG+RSLNL
Sbjct: 58 IFSAANVPIEWESCDVSPIF-VNGLTTIPDPAVQSITKNLVALKGPLATPIGKGHRSLNL 116
Query: 182 ALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLIT 361
LRK F L+ANVRP KS+EG KT Y+NVD+V IRENTEGEYSGIEH + GVVQSIKLIT
Sbjct: 117 TLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIRENTEGEYSGIEHIVCPGVVQSIKLIT 176
Query: 362 EEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+AS RV +AF++AR R +V VHK+ I R
Sbjct: 177 RDASERVIRYAFEYARAIGRPRVIVVHKSTIQR 209
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 175 bits (427), Expect = 4e-43
Identities = 80/153 (52%), Positives = 112/153 (73%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNL 181
+ EA + EWE A K IP++ +S+ +IGLKGP+ TP+G G+ S+N+
Sbjct: 24 VLEATGLKFEWESFAAGAEAYEKYKEYIPKELNESIERTRIGLKGPVTTPIGGGFSSINV 83
Query: 182 ALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLIT 361
LRK F+LYANVRP ++L G+ T Y VD+V +RENTEG YSGIEHE+V GVV+S+K+IT
Sbjct: 84 ELRKRFELYANVRPIRNLPGVHTRYPGVDLVVVRENTEGLYSGIEHEVVPGVVESLKIIT 143
Query: 362 EEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
E+ASTR+++FAF +AR+ RKK+ ++HKANIM+
Sbjct: 144 EKASTRISKFAFNYARKMGRKKIHSIHKANIMK 176
Score = 32.3 bits (70), Expect = 6.9
Identities = 11/19 (57%), Positives = 16/19 (84%)
Frame = +1
Query: 463 MSDGLFLRCCRELATKYPD 519
MSDGLF+RC R ++ +YP+
Sbjct: 177 MSDGLFIRCSRNISKEYPE 195
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 167 bits (407), Expect = 1e-40
Identities = 80/154 (51%), Positives = 111/154 (72%), Gaps = 1/154 (0%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGK-GYRSLN 178
IFE +PI+WE +D++ + + Q+A++S+ NK+GLKG TP + G+ SLN
Sbjct: 51 IFENENIPIDWETIDISGLENTENV----QRAVESLKRNKVGLKGIWHTPADQTGHGSLN 106
Query: 179 LALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLI 358
+ALRK+ D++ANV KS+ G+KT +N+D+V IRENTEGEYSG+EHE V GVV+S+K++
Sbjct: 107 VALRKQLDIFANVALFKSIPGVKTRLNNIDMVIIRENTEGEYSGLEHESVPGVVESLKIM 166
Query: 359 TEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
T S R+A FAF FA +N RK V AVHKANIM+
Sbjct: 167 TRAKSERIARFAFDFALKNNRKSVCAVHKANIMK 200
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 165 bits (401), Expect = 5e-40
Identities = 81/154 (52%), Positives = 114/154 (74%), Gaps = 1/154 (0%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGK-GYRSLN 178
IFEA +PI+WE +++ + D K G+ +A++S+ NKIGLKG TP + G+ SLN
Sbjct: 50 IFEAENIPIDWETINI---KQTDHKEGV-YEAVESLKRNKIGLKGLWHTPADQTGHGSLN 105
Query: 179 LALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLI 358
+ALRK+ D+YANV KSL+G+KT ++D++ IRENTEGE+SG+EHE V GVV+S+K++
Sbjct: 106 VALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVM 165
Query: 359 TEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
T + R+A FAF FA++ RK VTAVHKANIM+
Sbjct: 166 TRPKTERIARFAFDFAKKYNRKSVTAVHKANIMK 199
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 163 bits (395), Expect = 3e-39
Identities = 80/153 (52%), Positives = 111/153 (72%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNL 181
+ EA P+ +E +V G K +P++ I+SV NK+ LKG L TPVG G SLN+
Sbjct: 60 VMEAMHAPVHFERYEVL---GNMRK--VPEEVIESVKRNKVCLKGGLATPVGGGVSSLNM 114
Query: 182 ALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLIT 361
LRKE D++A++ C ++ G+ T ++NVD+V IRENTEGEYSG+EHE+V GVV+S+K+IT
Sbjct: 115 QLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVIT 174
Query: 362 EEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+ S R+A +AF++A N RKKVTAVHKANIM+
Sbjct: 175 KFCSERIARYAFEYAYLNNRKKVTAVHKANIMK 207
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 163 bits (395), Expect = 3e-39
Identities = 80/153 (52%), Positives = 112/153 (73%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNL 181
+ EA PI +E+ DV G + +P + ++S+ NK+ LKG L TPVG G SLN+
Sbjct: 59 VMEAMHAPIFFEKYDV---HGEMSR--VPPEVMESIRKNKVCLKGGLKTPVGGGVSSLNV 113
Query: 182 ALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLIT 361
LRKE DL+A++ C +L G+ T ++NVD+V IRENTEGEY+G+EHE+V GVV+S+K+IT
Sbjct: 114 QLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYAGLEHEVVPGVVESLKVIT 173
Query: 362 EEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+ S R+A++AF++A N RKKVTAVHKANIM+
Sbjct: 174 KFCSERIAKYAFEYAYLNNRKKVTAVHKANIMK 206
Score = 32.3 bits (70), Expect = 6.9
Identities = 12/18 (66%), Positives = 15/18 (83%)
Frame = +1
Query: 463 MSDGLFLRCCRELATKYP 516
++DGLFL CRE+A KYP
Sbjct: 207 LADGLFLESCREVAKKYP 224
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 159 bits (387), Expect = 3e-38
Identities = 76/157 (48%), Positives = 113/157 (71%), Gaps = 4/157 (2%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTA--VRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGK--GYR 169
IF VP+++EE++++ ++ D G +AI S+ N + +KG + TP+ G+R
Sbjct: 72 IFRHIGVPVDFEELNLSGLDIKDEDSYLGAFNEAITSIKRNGVAMKGNIFTPLDAIPGFR 131
Query: 170 SLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSI 349
SLNL LR DL+AN+ CKS+ GI+T ++NVD+V IR+NTEGEYS +EHE V GV++++
Sbjct: 132 SLNLELRVHLDLFANIVRCKSIPGIQTRHNNVDLVIIRQNTEGEYSHLEHENVSGVIENL 191
Query: 350 KLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
K+ TEEA ++A++AF FA ++ RKKVTAVHKANIM+
Sbjct: 192 KVTTEEACMKIAQYAFDFAEKHDRKKVTAVHKANIMK 228
Score = 34.3 bits (75), Expect = 1.7
Identities = 12/19 (63%), Positives = 15/19 (78%)
Frame = +1
Query: 463 MSDGLFLRCCRELATKYPD 519
M DGLFLRCC E++ YP+
Sbjct: 229 MGDGLFLRCCEEMSHSYPN 247
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 144 bits (349), Expect = 1e-33
Identities = 78/155 (50%), Positives = 101/155 (65%), Gaps = 2/155 (1%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVT-AVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPV-GKGYRSL 175
+F A VP+++E VD+ A G D + AI S+ N + LKG + T G S
Sbjct: 71 VFRFAGVPVDFEVVDIDPASEGNDDL----EYAITSIKRNGVALKGNIETKSEATGIISR 126
Query: 176 NLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKL 355
N+ALR E DLY NV CKS I + NVDVV IR+NTEGEY+ +EHE V GVV+S+K+
Sbjct: 127 NVALRNELDLYVNVLHCKSFNAIPAHHQNVDVVIIRQNTEGEYAMLEHESVRGVVESMKV 186
Query: 356 ITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+T E + RVA +AF+FAR N RKKVT +HKANIM+
Sbjct: 187 VTVENAARVARYAFEFARANNRKKVTTIHKANIMK 221
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 143 bits (347), Expect = 2e-33
Identities = 76/157 (48%), Positives = 109/157 (69%), Gaps = 4/157 (2%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTP----VGKGYR 169
+F++A VP+++E ++ V P + + I S+ NK+ +KG L TP VG+ +
Sbjct: 61 VFKSADVPVDFECYFLSEVN-PVLSAKL-EDVIASIRKNKVCIKGVLATPDYSNVGE-LQ 117
Query: 170 SLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSI 349
SLN+ LR E DLYANV +SL G+KT Y ++D+V IRE TEGEYS +EHE V G+V+ +
Sbjct: 118 SLNMKLRNELDLYANVVHARSLPGVKTRYQDIDIVVIREQTEGEYSALEHESVPGIVECL 177
Query: 350 KLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
K+IT + S R+A+FAF +A +N RKKVT+VHKANIM+
Sbjct: 178 KIITAKKSMRIAKFAFDYAIKNSRKKVTSVHKANIMK 214
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 142 bits (344), Expect = 4e-33
Identities = 73/155 (47%), Positives = 107/155 (69%), Gaps = 2/155 (1%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTP--VGKGYRSL 175
+F A VP+++EEV V++ + + AI ++ N++ LKG + T + ++S
Sbjct: 76 VFRHACVPVDFEEVHVSSNADEEDI----RNAIMAIRRNRVALKGNIETNHNLPPSHKSR 131
Query: 176 NLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKL 355
N LR DLYANV CKSL G+ T + ++D++ +RENTEGEYS +EHE V GVV+S+K+
Sbjct: 132 NNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKI 191
Query: 356 ITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
IT+ S R+AE+AF+ A+E+ RKKVTAVHKANIM+
Sbjct: 192 ITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMK 226
Score = 35.5 bits (78), Expect = 0.74
Identities = 12/18 (66%), Positives = 16/18 (88%)
Frame = +1
Query: 463 MSDGLFLRCCRELATKYP 516
+ DGLFL+CCRE+A +YP
Sbjct: 227 LGDGLFLQCCREVAARYP 244
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 141 bits (342), Expect = 8e-33
Identities = 78/175 (44%), Positives = 113/175 (64%), Gaps = 22/175 (12%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFG--IPQKAIDSVNANKIGLKGPLMTPVGKGYRSL 175
+ EA+ V +EW V+ V + K+G +P + ++S+ ++ +KGP+ TPVG G+RS+
Sbjct: 24 VLEASGVDLEWIRVEA-GVEVIE-KYGTPLPPQVLESIRETRVAIKGPIGTPVGTGFRSV 81
Query: 176 NLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHE----------- 322
N+A+RKE DLYAN+RP KSL GIK+ + ++D+V +RENTE Y+GIE E
Sbjct: 82 NVAIRKELDLYANLRPAKSLPGIKSPFQDIDLVVVRENTEDLYAGIEFERGTPEAAHARE 141
Query: 323 ---------IVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
I +G IK I+E S R+ +FAF++AR+N RKKVTAVHKANIM+
Sbjct: 142 EMMRLSGKFIREGSAIGIKPISEFGSRRIVKFAFEYARQNGRKKVTAVHKANIMK 196
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 136 bits (329), Expect = 3e-31
Identities = 71/173 (41%), Positives = 107/173 (61%), Gaps = 20/173 (11%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNL 181
+ +A + EW VD A +P I++V A+ +KGP+ TP G G RS+N+
Sbjct: 25 VLDATGIDFEWVVVDAGAEVMEKSGTPLPAPVIEAVRASDAAIKGPITTPAGSGIRSVNV 84
Query: 182 ALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEH--------EIVDGV 337
ALR+ DLYAN+RP ++L G+ + YDN+D+V +RENTE YSGIE E+++ +
Sbjct: 85 ALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRENTEDLYSGIEFEKNSPQALEVIEML 144
Query: 338 VQ------------SIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
++ ++K I+ EAS R+A FAF++AR + R+KVTAVHKANI++
Sbjct: 145 MRLGGKKIFPRSGLAVKPISSEASERIARFAFEYARRHARRKVTAVHKANILK 197
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 134 bits (324), Expect = 1e-30
Identities = 70/154 (45%), Positives = 99/154 (64%), Gaps = 1/154 (0%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYR-SLN 178
IF PI++E +D+ +G + AI S+ N + LKG + T S N
Sbjct: 79 IFRYCGAPIDFEVIDIDP--STEGNDDLDY-AITSIKRNGVALKGNIETKSQSLTEVSRN 135
Query: 179 LALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLI 358
+A+R E DLY NV CKS GI + ++DVV IR+NT+GEY+ +EHE V G+V+S+K++
Sbjct: 136 VAIRNELDLYVNVVHCKSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVV 195
Query: 359 TEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
T E + RVA +AF+FAR+N RKKVT +HKANIM+
Sbjct: 196 TVENAERVARYAFEFARQNNRKKVTTIHKANIMK 229
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 132 bits (319), Expect = 5e-30
Identities = 68/155 (43%), Positives = 104/155 (67%), Gaps = 2/155 (1%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVG-KG-YRSL 175
+F+AA VP+E++E ++ V+ + + Q + S+ NK+ + G + TP+ KG S
Sbjct: 70 VFKAAAVPVEFQEHHLSEVQNMASEEKLEQ-VLSSMKENKVAIIGKIHTPMEYKGELASY 128
Query: 176 NLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKL 355
++ LR++ DL+ANV KSL G T ++N+D+V IRE TEGEYS +EHE GV++ +K+
Sbjct: 129 DMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKI 188
Query: 356 ITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+T S R+A+FAF +A + R KVTAVHKANIM+
Sbjct: 189 VTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMK 223
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 129 bits (311), Expect = 4e-29
Identities = 67/156 (42%), Positives = 95/156 (60%), Gaps = 3/156 (1%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDG-KFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLN 178
+ EAAK P+ +E + A G G+PQ+ I+S+ ++ LKGPL TPVG G +S N
Sbjct: 41 VLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESIRKTRVVLKGPLETPVGYGEKSAN 100
Query: 179 LALRKEFDLYANVRPCKSLEGIKTLY--DNVDVVTIRENTEGEYSGIEHEIVDGVVQSIK 352
+ LRK F+ YANVRP + + T Y +D+V +REN E Y+GIEH V Q++K
Sbjct: 101 VTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVVRENVEDLYAGIEHMQTPSVAQTLK 160
Query: 353 LITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
LI+ + S ++ FAF+ AR RKKV K+NIM+
Sbjct: 161 LISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMK 196
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 126 bits (304), Expect = 3e-28
Identities = 64/150 (42%), Positives = 93/150 (62%)
Frame = +2
Query: 11 AAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALR 190
A K PIEW+ D + D + + + S+ ANK+G+KGP+ + R +R
Sbjct: 94 AVKAPIEWDVHDEFKAKDSDD---VSPEVLKSLRANKVGIKGPVDS------RHWQRQIR 144
Query: 191 KEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEA 370
K+F +A V C +EG+ + Y + DVV IR+ EG+YSGIEH +V GV+Q+IK+ T
Sbjct: 145 KQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEGDYSGIEHLVVPGVMQTIKVSTTAG 204
Query: 371 STRVAEFAFQFARENKRKKVTAVHKANIMR 460
+ R+AEF F +A +NKRK++T HKANIMR
Sbjct: 205 AARIAEFVFNYAVKNKRKRITVAHKANIMR 234
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 121 bits (292), Expect = 9e-27
Identities = 65/160 (40%), Positives = 96/160 (60%), Gaps = 7/160 (4%)
Frame = +2
Query: 2 IFEAAKVPIEWE--EVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSL 175
+F+A P WE + V A+ G +PQ +DS+ + LKGPL TP+G G+RS+
Sbjct: 31 VFDALGNPFAWETQQAGVNALE-KSGDL-LPQTTLDSIGRTGLALKGPLSTPIGGGFRSV 88
Query: 176 NLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDG-----VV 340
N+ LR+ F LYANVRP +++ Y+ +D+V +REN EG Y G EH + G V
Sbjct: 89 NVRLRETFQLYANVRPARTIVP-GGRYEKIDLVLVRENLEGLYVGHEHYVPIGDDAHAVA 147
Query: 341 QSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+ + T S R+++FAF +A N R+KVT VHKAN+++
Sbjct: 148 MATGINTRAGSRRISKFAFDYAVRNNRRKVTIVHKANVLK 187
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 120 bits (289), Expect = 2e-26
Identities = 65/177 (36%), Positives = 106/177 (59%), Gaps = 26/177 (14%)
Frame = +2
Query: 8 EAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLAL 187
+A V I+W+ V + + + G+P + +DS+ ANKI LK P+ TP+GKG+RS+N+ L
Sbjct: 25 DATGVKIDWD-VQECGIEVIEAEGGVPDRVMDSIRANKIALKAPITTPIGKGFRSVNVFL 83
Query: 188 RKEFDLYANVRPCKSLEGIKTLY--DNVDVVTIRENTEGEYSGIEHEI------------ 325
R+E LYA +RPCK+ +G++T + NVD+V +RENTE Y+G+E +
Sbjct: 84 RQELGLYACIRPCKTYKGVRTYFADSNVDLVVVRENTEDLYAGVEFQAGQEKTAELIKKI 143
Query: 326 ------------VDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+D SIK ++ + + + +AF++A +NKR+ VT++ KANIM+
Sbjct: 144 NEFATGKKINTPLDETGVSIKPMSYQGTRDICNYAFKYAVDNKRQSVTSICKANIMK 200
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 120 bits (288), Expect = 3e-26
Identities = 62/155 (40%), Positives = 94/155 (60%), Gaps = 2/155 (1%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVR-GPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLN 178
I + A+ + E VD+ + + GI A +S++ ++ LK P MTP G G++SLN
Sbjct: 29 ILKEARADVSIETVDIGHNQYKKEWTSGIAPSAWESISRTRLLLKAPTMTPQGSGHKSLN 88
Query: 179 LALRKEFDLYANVRPCKS-LEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKL 355
+ALR+ LY NVRPC S + T + ++DVV IREN E YSG+EH++ + + +K+
Sbjct: 89 VALRQRLGLYVNVRPCVSYFPVVGTKHPDLDVVIIRENEEDTYSGVEHKLSEDTHECVKI 148
Query: 356 ITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
T AS ++ +AF +AR + RKKVT K NIM+
Sbjct: 149 STRSASEKICAYAFNYARAHNRKKVTCFVKDNIMK 183
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 118 bits (283), Expect = 1e-25
Identities = 65/153 (42%), Positives = 92/153 (60%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNL 181
I E +PIE+ EV+ +P+ ++ ++ I LKGP VG+ + +
Sbjct: 28 INELYSLPIEYIEVEAGDRALARYGEALPKDSLKIIDKADIILKGP----VGESAADVVV 83
Query: 182 ALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLIT 361
LR+ +D+YAN+RP KS+ GI T Y NVD++ +RENTE Y G EH + DGV +K+IT
Sbjct: 84 KLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVRENTEDLYKGFEHIVSDGVAVGMKIIT 143
Query: 362 EEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
AS R+A+ FA +RKKVT VHKAN+MR
Sbjct: 144 RFASERIAKVGLNFAL-RRRKKVTCVHKANVMR 175
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 113 bits (271), Expect = 3e-24
Identities = 59/155 (38%), Positives = 87/155 (56%), Gaps = 2/155 (1%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDV-TAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLN 178
+ + A VP+ E +++ + +GI + + K LKGP+ TP G GY+SLN
Sbjct: 26 VLKEAAVPLRLETIEIGEKLYNKYYTYGITEDTWSQIFRTKALLKGPVTTPQGGGYKSLN 85
Query: 179 LALRKEFDLYANVRP-CKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKL 355
+ LRK LYANVRP C + T +DVV IREN E Y+GIE+ +S+KL
Sbjct: 86 VTLRKTLGLYANVRPSCSYFPFVNTSAPEIDVVIIRENEEDLYAGIEYHHTADTYESVKL 145
Query: 356 ITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
I+ S ++ FAF++A +N RK ++ K NIM+
Sbjct: 146 ISRSGSEKIIRFAFEYALKNNRKTISCFSKDNIMK 180
>UniRef50_Q4UKR1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=29; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Rickettsia felis (Rickettsia azadi)
Length = 483
Score = 107 bits (256), Expect = 2e-22
Identities = 52/128 (40%), Positives = 81/128 (63%), Gaps = 1/128 (0%)
Frame = +2
Query: 80 GIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIK-TLY 256
GI +++ +S+ I LK P+ TP G GY+SLN+ +RK L+AN+RP S TL+
Sbjct: 53 GISEESWESIQRTGIILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFHPFTMTLH 112
Query: 257 DNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTA 436
++++ IREN E Y+GIE+ + +SIKLI+ ++ +AF++A +N RKKVT
Sbjct: 113 PHLNLTIIRENEEDLYAGIEYRQTHNMYESIKLISHTGCEKIIRYAFEYAVKNNRKKVTC 172
Query: 437 VHKANIMR 460
+ K NIM+
Sbjct: 173 LSKDNIMK 180
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 103 bits (248), Expect = 2e-21
Identities = 50/107 (46%), Positives = 72/107 (67%)
Frame = +2
Query: 140 LMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEH 319
L G+ + + LR+E +ANVRP K++EGI+ LY +D+V +RENTE Y G E
Sbjct: 65 LFGAAGETAADVIVRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTECLYMGFEF 124
Query: 320 EIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
D V ++I++IT EAS R+A +AF+ A+ RKKVTA+HKAN+M+
Sbjct: 125 GFGD-VTEAIRVITREASERIARYAFELAKREGRKKVTALHKANVMK 170
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 103 bits (248), Expect = 2e-21
Identities = 53/118 (44%), Positives = 81/118 (68%), Gaps = 1/118 (0%)
Frame = +2
Query: 92 KAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDV 271
+ +DS+ NK+ L G + + G RKE DL+A++ C +L G + ++NVD+
Sbjct: 45 EVVDSIRKNKVCLNGRVNNSLCGG-------ARKELDLFASLVDCFNLNGQPSRHENVDI 97
Query: 272 VTIRENTEGEYSGIEHEIVDGVVQSIKL-ITEEASTRVAEFAFQFARENKRKKVTAVH 442
V IRENTEGEY+G EHE+V GV++S ++ +T+ S R+A++AF++A +KRKKVTAVH
Sbjct: 98 VVIRENTEGEYAGREHEVVPGVIESFQVTMTKFWSDRIAKYAFEYAHFSKRKKVTAVH 155
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 103 bits (247), Expect = 2e-21
Identities = 52/126 (41%), Positives = 82/126 (65%)
Frame = +2
Query: 83 IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN 262
+P++ +++V + L G G+ + + LR+EFDL+AN+RP KSL G+ LY +
Sbjct: 52 LPEETLEAVGEARATLFGA----AGESAADVIVRLRREFDLFANLRPVKSLPGVPCLYPD 107
Query: 263 VDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVH 442
+D V +RENTE Y G E +G V ++IT AS R+++FAFQ+A++ +KVTAVH
Sbjct: 108 LDFVIVRENTEDLYVGDEEYTPEGAVAK-RIITRTASRRISQFAFQYAQKEGMQKVTAVH 166
Query: 443 KANIMR 460
KAN+++
Sbjct: 167 KANVLK 172
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 100 bits (240), Expect = 2e-20
Identities = 62/152 (40%), Positives = 85/152 (55%), Gaps = 26/152 (17%)
Frame = +2
Query: 83 IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN 262
+P+ + ++ +++ +KGPL TPVG G+RSLN+ALRK DLYANVRP L+G+ + N
Sbjct: 126 LPEDTVSAIRDHRVAIKGPLTTPVGAGFRSLNVALRKTLDLYANVRPTYYLDGVPSPVKN 185
Query: 263 ---VDVVTIRENTEGEYSGIEHE----------------------IVDGVVQ-SIKLITE 364
+D++T RENTE Y+GIE E I DG V +K I+E
Sbjct: 186 PEKMDMITFRENTEDVYAGIEWEAGTDEVEQVRDFLEDDMEIADVIHDGPVGIGVKPISE 245
Query: 365 EASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
S R+ A +A N R VT VHK NIM+
Sbjct: 246 FGSKRLIREAIDYALANDRDSVTLVHKGNIMK 277
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 100 bits (239), Expect = 2e-20
Identities = 48/108 (44%), Positives = 75/108 (69%), Gaps = 1/108 (0%)
Frame = +2
Query: 140 LMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEH 319
+ PVG+ + + LR+ DLYAN+RP KS + L D++D+V +RENTE Y+G E
Sbjct: 69 MKAPVGESAADVIVVLRRMLDLYANIRPAKSYPHMPALRDDIDMVIVRENTEDLYTGKEF 128
Query: 320 EIVDGVVQSIKLITEEASTRVAEFAFQFAR-ENKRKKVTAVHKANIMR 460
+ D V ++++I+E+AS R+A++AF+ A+ N +KKVT VHK+N+MR
Sbjct: 129 SLGDSSV-ALRIISEQASKRIAKYAFETAKMRNDKKKVTCVHKSNVMR 175
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 98.3 bits (234), Expect = 9e-20
Identities = 57/158 (36%), Positives = 88/158 (55%), Gaps = 5/158 (3%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDV-TAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLN 178
+ EA +P E+ + V GK +P++ I++ + L G+ +
Sbjct: 23 VLEATGLPFEFVYAEAGDEVYKRTGK-ALPEETIETA----LDCDAVLFGAAGETAADVI 77
Query: 179 LALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLI 358
+ LR D YAN+RP K+ +G+K L ++D V +RENTEG Y GIE EI +G+ + ++I
Sbjct: 78 VKLRHILDTYANIRPVKAYKGVKCLRPDIDYVIVRENTEGLYKGIEAEIDEGITIATRVI 137
Query: 359 TEEASTRVAEFAFQFARENKRK----KVTAVHKANIMR 460
TE+A R+ FAF ARE K+ KVT HKAN+++
Sbjct: 138 TEKACERIFRFAFNLARERKKMGKEGKVTCAHKANVLK 175
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 96.7 bits (230), Expect = 3e-19
Identities = 45/92 (48%), Positives = 65/92 (70%)
Frame = +2
Query: 185 LRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITE 364
L DLYA+V K+L ++T + +VD++ + ENTEGEYS +EHE V GV +S+K++T+
Sbjct: 2 LHTTLDLYASVIHLKNLPNVETWHKDVDILVVWENTEGEYSNLEHESVKGVTESLKIMTK 61
Query: 365 EASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
S R+AE+AFQ A++ KKV AVHK NI +
Sbjct: 62 AKSLRIAEYAFQLAQKMGCKKVMAVHKVNITK 93
>UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=73; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Staphylococcus epidermidis (strain ATCC 35984 /
RP62A)
Length = 422
Score = 96.3 bits (229), Expect = 4e-19
Identities = 61/171 (35%), Positives = 94/171 (54%), Gaps = 26/171 (15%)
Frame = +2
Query: 26 IEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDL 205
IEW+EV + +PQ+ ++++ I +KGPL TP+G G RSLN+ALR+E DL
Sbjct: 55 IEWKEVLAGQKAYDETGEWLPQETLETIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDL 114
Query: 206 YANVRPCKSLEGIKTLY---DNVDVVTIRENTEGEYSGIE--------HEIVD------G 334
+ +RP + +G+ + ++VD+V RENTE Y+GIE +++D G
Sbjct: 115 FTCLRPVRWFKGVPSPVKRPEDVDMVIFRENTEDIYAGIEFKQGTSEVKKVIDFLQNEMG 174
Query: 335 VVQ---------SIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
IK +++E + R+ A Q+A +N RK VT VHK NIM+
Sbjct: 175 ATNIRFPETSGIGIKPVSKEGTERLVRAAIQYALDNNRKSVTLVHKGNIMK 225
>UniRef50_O29610 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=15; Archaea|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Archaeoglobus fulgidus
Length = 412
Score = 95.5 bits (227), Expect = 7e-19
Identities = 61/149 (40%), Positives = 84/149 (56%), Gaps = 23/149 (15%)
Frame = +2
Query: 83 IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY-- 256
+P ++++ ++ LKGPL TPVG GYRSLN+ +R+ DLYANVRP L+G+ +
Sbjct: 80 LPDDTLNAIKEFRVALKGPLTTPVGGGYRSLNVTIRQVLDLYANVRPVYYLKGVPSPIKH 139
Query: 257 -DNVDVVTIRENTEGEYSGIE-----HEIVD---------GVV------QSIKLITEEAS 373
+ V+ V RENTE Y+GIE E + GV IK I+E A+
Sbjct: 140 PEKVNFVIFRENTEDVYAGIEWPRGSEEALKLIRFLKNEFGVTIREDSGIGIKPISEFAT 199
Query: 374 TRVAEFAFQFARENKRKKVTAVHKANIMR 460
R+ A ++A EN RK VT VHK NIM+
Sbjct: 200 KRLVRMAIRYAIENNRKSVTLVHKGNIMK 228
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 92.7 bits (220), Expect = 5e-18
Identities = 64/176 (36%), Positives = 94/176 (53%), Gaps = 28/176 (15%)
Frame = +2
Query: 17 KVPIEWEEV--DVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALR 190
K I W +V A + DG + PQ+ I +V A KI +KGPL TP+G G+RSLN+ALR
Sbjct: 62 KRKIHWMQVFNGEQAAKLYDGDW-FPQETIQAVRACKIAIKGPLTTPLGGGFRSLNVALR 120
Query: 191 KEFDLYANVRPCKSLEGIKTLYDN---VDVVTIRENTEGEYSGIE--------HEIVD-- 331
+E DL+ N+R K + + N ++ +R+++E YSGIE +++D
Sbjct: 121 QEMDLFVNMRTIKGFSALPSPLKNPFLTNITVLRDSSEDVYSGIEWQAGSIESEKMLDFL 180
Query: 332 ----GVVQ---------SIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
GV + IK I++E S R+ FA FA N R VT VHK N+++
Sbjct: 181 CEEMGVTRLRFSQDCGIGIKNISKEGSERLTRFALNFALNNNRDSVTFVHKGNVLK 236
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 91.9 bits (218), Expect = 8e-18
Identities = 46/127 (36%), Positives = 77/127 (60%), Gaps = 1/127 (0%)
Frame = +2
Query: 83 IPQKAIDSVNANKIGLKGPLMTPVGKGY-RSLNLALRKEFDLYANVRPCKSLEGIKTLYD 259
+P + ++++ KGP TP G G RS+ +++R+++DLYANVRP K+
Sbjct: 53 VPDETWQILDSSDACFKGPTTTPGGIGSPRSVAVSIRRKYDLYANVRPIKTFPNSNAPLG 112
Query: 260 NVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAV 439
+V++V +RE TEG Y G E ++ D V +I+ IT AS ++A +AF+ A+ V +
Sbjct: 113 DVEMVCVREGTEGLYIGEEIQLTDDVSIAIRKITRTASGKIARYAFEEAKRRGYDTVVPI 172
Query: 440 HKANIMR 460
HK+NI++
Sbjct: 173 HKSNILK 179
>UniRef50_Q2UP37 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Aspergillus oryzae|Rep: Isocitrate/isopropylmalate
dehydrogenase - Aspergillus oryzae
Length = 350
Score = 91.1 bits (216), Expect = 1e-17
Identities = 52/166 (31%), Positives = 89/166 (53%), Gaps = 14/166 (8%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKG------ 163
+ EA + EW+ + + +P + I + K +K PL+ G
Sbjct: 22 VIEATGIQPEWDFIPIADEAVRLYGHALPPQVIQRIKDVKFCIKAPLLAEKLHGRISCTQ 81
Query: 164 -------YRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHE 322
Y S+N A+R+E +L+ N RP + GI ++ +D+V +RE TE Y G E
Sbjct: 82 TDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISGRHEKMDMVIMREITEDTYIGWEKP 141
Query: 323 IVDG-VVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
+ DG ++IK +T AS +V+++AF++AR++ RKKV+ +HKAN++
Sbjct: 142 LEDGAAAEAIKRVTRSASWKVSQYAFEYARKHGRKKVSCLHKANVL 187
>UniRef50_Q8ZW34 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Thermoproteaceae|Rep: 3-isopropylmalate dehydrogenase -
Pyrobaculum aerophilum
Length = 290
Score = 89.4 bits (212), Expect = 4e-17
Identities = 50/131 (38%), Positives = 83/131 (63%), Gaps = 2/131 (1%)
Frame = +2
Query: 74 KFG--IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIK 247
K+G +PQ+A+ +A + KGP +G+ + +R + LYAN+RP K+L G+
Sbjct: 15 KYGTAMPQEALRLADAADVIFKGP----IGESAYDVTSLIRMRYTLYANIRPVKNLPGVP 70
Query: 248 TLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKK 427
+ + +D V +REN E Y G E+++ D V ++K+ITE+ + RVA A ++A E +R++
Sbjct: 71 AVRE-IDCVFVRENVEDVYVGAEYKVGD-VAIALKVITEKGTRRVARMARKYA-EMRRRR 127
Query: 428 VTAVHKANIMR 460
VT VHKAN++R
Sbjct: 128 VTIVHKANVLR 138
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 89.0 bits (211), Expect = 6e-17
Identities = 59/160 (36%), Positives = 92/160 (57%), Gaps = 7/160 (4%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFG--IPQKAIDSVNANKIGLKGPLMTPVGKGYRSL 175
I E K+P+E+ V V A K+G +P+++ + + LKGP VG+ +
Sbjct: 27 IRETFKLPLEF--VFVEAGDRAKEKYGEALPKESYERLLRADAILKGP----VGETAADV 80
Query: 176 NLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEH-----EIVDGVV 340
+ LR+E DL+AN+RP K L G+ L +NVD++ +REN E Y G E+ + V
Sbjct: 81 IVRLRRELDLFANIRPAKVLPGVPALKENVDLIIVRENIEDLYVGAENLLPQTSLGHKVA 140
Query: 341 QSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
++L +E + RVA+ A ++A+ +R KVT VHKAN+MR
Sbjct: 141 VGLRLASERETRRVAKVAAEYAKA-RRNKVTIVHKANVMR 179
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 87.0 bits (206), Expect = 2e-16
Identities = 41/87 (47%), Positives = 61/87 (70%)
Frame = +2
Query: 200 DLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTR 379
DL ANV +S ++T + N+D++ +R+NTEGEYS +E E ++ VV+S++ +T+ R
Sbjct: 17 DLCANVVQFESQPRVETRHKNIDILVVRDNTEGEYSNLEDESMNRVVESLRTVTKAKCLR 76
Query: 380 VAEFAFQFARENKRKKVTAVHKANIMR 460
+AE+AFQ A KKVTA +KANIMR
Sbjct: 77 LAEYAFQLAHRMGCKKVTATYKANIMR 103
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 85.4 bits (202), Expect = 7e-16
Identities = 46/116 (39%), Positives = 74/116 (63%), Gaps = 2/116 (1%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVG-KG-YRSL 175
+F+AA VP+E++E ++ V+ + + Q + S+ NK+ + G + TP+ KG S
Sbjct: 70 VFKAAAVPVEFQEHHLSEVQNMASEEKLEQ-VLSSMKENKVAIIGKIHTPMEYKGELASY 128
Query: 176 NLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQ 343
++ LR++ DL+ANV KSL G T ++N+D+V IRE TEGEYS +EHE + V +
Sbjct: 129 DMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHECCEEVAE 184
>UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2;
Thermoplasmatales|Rep: Isocitrate dehydrogenase [NADP] -
Picrophilus torridus
Length = 392
Score = 85.0 bits (201), Expect = 9e-16
Identities = 55/172 (31%), Positives = 91/172 (52%), Gaps = 24/172 (13%)
Frame = +2
Query: 17 KVPIEWEEVDVTAVRGPDGKFG-IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRK 193
K I W+E+ + R + K P+++I ++N ++ LK PL TPVGKG++S+N+ +R
Sbjct: 47 KKSIAWKEI-LLGDRAEELKGDRFPEESIKAINDYRVLLKAPLNTPVGKGFKSINVRIRM 105
Query: 194 EFDLYANVRPCKSLEGIKTLYDN---VDVVTIRENTEGEYSGIEH--------------- 319
DLYAN+RP K + G+++ N V++ RENT+ Y G E
Sbjct: 106 LLDLYANIRPVKFMPGLESPLKNPEKVNLTIFRENTDDLYLGYEWSYDTDEAKRIRKFLK 165
Query: 320 -----EIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+I D IK ++ + R+ A ++A +N KK+T +HK N+M+
Sbjct: 166 DEFNIDISDDSGIGIKPMSRYKTQRITRLAVKYAMDNNLKKITIMHKGNVMK 217
>UniRef50_Q58991 Cluster: Threo-isocitrate dehydrogenase [NAD]; n=9;
Methanococcales|Rep: Threo-isocitrate dehydrogenase
[NAD] - Methanococcus jannaschii
Length = 347
Score = 83.8 bits (198), Expect = 2e-15
Identities = 63/172 (36%), Positives = 93/172 (54%), Gaps = 21/172 (12%)
Frame = +2
Query: 8 EAAKVPIEWEEVDVTAVRGPDG-----KFG--IPQKAIDSVNANKIGLKGPLMTPVG--- 157
EA K+ E E ++ ++G G K+G +P+ I+ I L G + +P
Sbjct: 19 EAIKILNELGEFEI--IKGEAGLECLKKYGNALPEDTIEKAKEADIILFGAITSPKPGEV 76
Query: 158 KGYRSLNLALRKEFDLYANVRPCKSLEGIKTL------YD-----NVDVVTIRENTEGEY 304
+ Y+S + LRK F LYANVRP + GI L Y+ N+D+V IRENTE Y
Sbjct: 77 QNYKSPIITLRKMFHLYANVRPINNF-GIGQLIGKIADYEFLNAKNIDIVIIRENTEDLY 135
Query: 305 SGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
G E D + ++IT + S R+ FAF++A +N RKKV+ +HKAN++R
Sbjct: 136 VGRERLENDTAIAE-RVITRKGSERIIRFAFEYAIKNNRKKVSCIHKANVLR 186
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 83.4 bits (197), Expect = 3e-15
Identities = 48/127 (37%), Positives = 72/127 (56%), Gaps = 1/127 (0%)
Frame = +2
Query: 83 IPQKAIDSVNANKIGLKGPLMT-PVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYD 259
IP + + KGP T PV RS+ + LR++FDLYAN+RP K+ + + T
Sbjct: 55 IPDVTMKILEETDCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRL-TPDR 113
Query: 260 NVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAV 439
+D V RE TEG Y+G+E +I D +I+ IT + S R+ + A +A + KK+ AV
Sbjct: 114 KLDCVCFREATEGLYTGVEAKITDDAAIAIRKITRQGSRRLIDSAVDWANKFNMKKMVAV 173
Query: 440 HKANIMR 460
K NI++
Sbjct: 174 TKRNILK 180
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 83.4 bits (197), Expect = 3e-15
Identities = 50/133 (37%), Positives = 73/133 (54%), Gaps = 7/133 (5%)
Frame = +2
Query: 83 IPQKAIDSVNANKIGLKGPLMTPVGKG-----YRSLNLALRKEFDLYANVRPCKSLEGIK 247
+P A+D++ + LKGPL TP KG S N+A+R+E DL+ANVRP +
Sbjct: 71 LPDDALDALKKCHVILKGPLTTPK-KGDPWPNLESANVAMRRELDLFANVRP------VS 123
Query: 248 TLYDNVDVVTIRENTEGEY--SGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKR 421
+ +D V RENTEGEY + D + K+IT + S R+ AF +AR N
Sbjct: 124 IPSEGIDWVFFRENTEGEYVLGSKGFNVTDDLAVDFKVITTQGSERIIRLAFDYARRNNI 183
Query: 422 KKVTAVHKANIMR 460
+V+ V KAN+++
Sbjct: 184 NRVSVVTKANVVK 196
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 80.6 bits (190), Expect = 2e-14
Identities = 52/157 (33%), Positives = 88/157 (56%), Gaps = 25/157 (15%)
Frame = +2
Query: 65 PDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGI 244
P+ ++ +P I+++N K+ +KGPL TP+G+G+RSLN+ALR++ DLY +RP +
Sbjct: 89 PEEQWLLPD-TIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSP 147
Query: 245 KTLYD--NVDVVTIRENTEGEYSGIE----------------HEIVDGVVQ-------SI 349
+ + VD+V REN+E Y+GIE +E+ ++ +
Sbjct: 148 SPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESSGIGV 207
Query: 350 KLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
K I++E + R+ A ++A +N + VT VHK NIM+
Sbjct: 208 KPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMK 244
>UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2;
Deinococcus|Rep: Isocitrate dehydrogenase, putative -
Deinococcus radiodurans
Length = 333
Score = 80.2 bits (189), Expect = 3e-14
Identities = 51/155 (32%), Positives = 81/155 (52%), Gaps = 3/155 (1%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGK---GYRS 172
+ EAA E+ + D +P+ D+V L G +P G+ G+
Sbjct: 25 VLEAAGFDAEYVHAEAGYEYFLDHGTSVPEATYDAVENTDATLFGAATSPSGEKPAGFFG 84
Query: 173 LNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIK 352
LR++++LYANVRP K+ + Y+NVD+V +RENT+G Y E D +
Sbjct: 85 AIRHLRQKYNLYANVRPTKT-RPVPHSYENVDLVIVRENTQGLYVEQERRYGDTAIAD-T 142
Query: 353 LITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
+IT EAS R+ +FA A + + K++T VHK+N++
Sbjct: 143 VITREASDRIGKFAADLAMK-RSKRLTVVHKSNVL 176
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 78.6 bits (185), Expect = 8e-14
Identities = 55/164 (33%), Positives = 85/164 (51%), Gaps = 15/164 (9%)
Frame = +2
Query: 14 AKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVG-KGYRSLNLA-- 184
A + I+W +V + A +P+ ++++ GL G ++ P+G + Y + A
Sbjct: 35 AGLGIDWTDVPIGAAALESHGHTMPEGTMETLE----GLDGWILGPIGHRDYPKVPGAIN 90
Query: 185 ----LRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEG--------EYSGIEHEIV 328
LRK FDL+ANVRP +S GI L+D++D+V +REN EG SG E
Sbjct: 91 PHPILRKGFDLFANVRPTRSYPGIGCLFDDIDLVIVRENNEGFQPDRNVVAGSG-EFRPT 149
Query: 329 DGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+ V S+++IT E +V A AR RKK+T VHK + +
Sbjct: 150 EDVTISVRVITVEGCRKVVRAALDIARSRPRKKLTLVHKNTVFK 193
>UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 419
Score = 78.6 bits (185), Expect = 8e-14
Identities = 48/128 (37%), Positives = 69/128 (53%), Gaps = 6/128 (4%)
Frame = +2
Query: 26 IEWEEVDV--TAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEF 199
I W EV A + D +PQ+ +D+V + +KGPL TPVG G RSLN+ALR++
Sbjct: 65 ISWMEVYAGEKATQVYDQDTWLPQETLDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQQL 124
Query: 200 DLYANVRPCKSLEGIKTLY---DNVDVVTIRENTEGEYSGIEHEI-VDGVVQSIKLITEE 367
DLY +RP + EG+ + +VD+ REN+E Y+GIE + + IK + EE
Sbjct: 125 DLYVCLRPVRWFEGVPSPVKKPGDVDMTIFRENSEDIYAGIEWKAGSPEATKVIKFLKEE 184
Query: 368 ASTRVAEF 391
F
Sbjct: 185 MGVTKIRF 192
>UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp -
Pasteurella multocida
Length = 415
Score = 77.8 bits (183), Expect = 1e-13
Identities = 49/152 (32%), Positives = 82/152 (53%), Gaps = 26/152 (17%)
Frame = +2
Query: 83 IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN 262
+P + + + + +KGPLMTPVG G RSLN+A+R+ DLY +RP + +G + +
Sbjct: 84 LPDETMTFIRDYHVAIKGPLMTPVGGGIRSLNVAMRQGLDLYNCLRPIRYYDGTPSPVKH 143
Query: 263 ---VDVVTIRENTEGEYSGIE--------HEIVDGVVQ---------------SIKLITE 364
VD+V REN+E Y+G+E ++++ + Q IK +++
Sbjct: 144 PELVDMVIFRENSEDIYAGVEWVAGSAEANKVIAFLQQEMGVKKIRFTEDCGIGIKPVSK 203
Query: 365 EASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+ + R+ A Q+ +N RK +T VHK NIM+
Sbjct: 204 QGTQRLVRAALQYVIDNDRKSLTLVHKGNIMK 235
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 77.4 bits (182), Expect = 2e-13
Identities = 40/98 (40%), Positives = 59/98 (60%), Gaps = 4/98 (4%)
Frame = +2
Query: 86 PQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY--- 256
P+ + ++ + +KGPL TPVG G RSLN+ALR+ FDLY VRPC+ G + +
Sbjct: 85 PEDTLTAIKEYGVAIKGPLTTPVGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSPHKTP 144
Query: 257 DNVDVVTIRENTEGEYSGIE-HEIVDGVVQSIKLITEE 367
+ +D++ RENTE Y GIE E +G + I + +E
Sbjct: 145 EKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLNDE 182
>UniRef50_O67480 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=3; Aquificaceae|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Aquifex aeolicus
Length = 426
Score = 77.4 bits (182), Expect = 2e-13
Identities = 54/152 (35%), Positives = 81/152 (53%), Gaps = 26/152 (17%)
Frame = +2
Query: 83 IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN 262
+PQ+ +D + + +G+KGPL TPVGKG RS+N ALR+ FD Y+ VRP + G T N
Sbjct: 94 LPQETLDVLKESIVGIKGPLGTPVGKGVRSINSALRRAFDYYSAVRPVYWM-GQATPIPN 152
Query: 263 ---VDVVTIRENTEGEYSGIE-----------HEIV------------DGVVQSIKLITE 364
VD+V RENT+ Y+G+E E + + V ++K ++E
Sbjct: 153 PERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSE 212
Query: 365 EASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+ R A ++A EN +K V + K NIM+
Sbjct: 213 FKTKRHVRKALRYALENNKKNVAVIGKGNIMK 244
>UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=4; Chloroflexaceae|Rep: Isocitrate dehydrogenase,
NADP-dependent - Roseiflexus sp. RS-1
Length = 453
Score = 76.6 bits (180), Expect = 3e-13
Identities = 36/82 (43%), Positives = 55/82 (67%), Gaps = 3/82 (3%)
Frame = +2
Query: 83 IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY-- 256
+P + +++ +G+KGPL TPVG+G RSLN+ALR+ DLY +RP + +G+ +
Sbjct: 82 LPDETVEAFRQYLVGIKGPLTTPVGRGIRSLNVALRQLLDLYVCLRPVRYFQGVPSPVKR 141
Query: 257 -DNVDVVTIRENTEGEYSGIEH 319
+ VD+V RENTE Y+GIE+
Sbjct: 142 PELVDMVIFRENTEDIYAGIEY 163
Score = 33.5 bits (73), Expect = 3.0
Identities = 15/38 (39%), Positives = 24/38 (63%)
Frame = +2
Query: 347 IKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
IK ++ + R+ A Q+A ++R+ VT VHK NIM+
Sbjct: 218 IKPVSRLGTERLVAAAIQYAITHRRRSVTFVHKGNIMK 255
>UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5;
Euryarchaeota|Rep: 2-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 324
Score = 76.6 bits (180), Expect = 3e-13
Identities = 48/121 (39%), Positives = 70/121 (57%)
Frame = +2
Query: 98 IDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVT 277
+++V A L G + +P GK YRS+ L LRKE DLYAN+RP +S V+
Sbjct: 54 LETVKACDCVLFGAITSPPGKPYRSIILTLRKELDLYANIRPFRS---CPISPRKVNFTI 110
Query: 278 IRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
REN+E Y GIE EI +S+++IT +AS R+A A + K+T VHK+N++
Sbjct: 111 YRENSEDLYMGIE-EITGDEARSVRVITRKASERIARAA---CSKPGIGKLTIVHKSNVL 166
Query: 458 R 460
+
Sbjct: 167 K 167
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 73.3 bits (172), Expect = 3e-12
Identities = 39/98 (39%), Positives = 60/98 (61%), Gaps = 7/98 (7%)
Frame = +2
Query: 185 LRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYS-------GIEHEIVDGVVQ 343
+RK FDL+AN+RP +SLEG+ + ++D+V +RENTEG Y+ E V
Sbjct: 102 VRKRFDLFANIRPARSLEGVASTVPDMDLVIVRENTEGLYADRNMFAGSGEFMPTPDVAL 161
Query: 344 SIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
++ ++T +A R+A AF AR + + VT VHKAN++
Sbjct: 162 AVGVVTRKACERIAHTAFALAR-TRGRHVTIVHKANVL 198
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 70.5 bits (165), Expect = 2e-11
Identities = 45/112 (40%), Positives = 64/112 (57%), Gaps = 1/112 (0%)
Frame = +2
Query: 128 LKGPLMTPVG-KGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEY 304
L G TP GYRSL + LRKE DLYAN+R I L + ++V +RENTEG Y
Sbjct: 65 LFGATTTPFNVPGYRSLIVTLRKELDLYANLRI------IPDLSNGKEIVIVRENTEGLY 118
Query: 305 SGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+ D + ++IT E + R+A+FA A+E + +T VHKAN+++
Sbjct: 119 ARDGIGFSDRAI-DFRIITLEGARRIAKFAINLAKE-RNSFITFVHKANVLK 168
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 68.5 bits (160), Expect = 9e-11
Identities = 56/159 (35%), Positives = 78/159 (49%), Gaps = 8/159 (5%)
Frame = +2
Query: 5 FEAAKVPIEWEEVDVTAVRGPDGKFGIPQ-KAIDSVNANKIGLKGPLMTPVGKGYRSLNL 181
FE + P E T PD + I + K D++ IG P + P G R + L
Sbjct: 36 FEFKEYPFGAEHYLKTGETLPD--WAIEEFKKFDAIYFGAIG--DPRVKP-GILERGILL 90
Query: 182 ALRKEFDLYANVRPCKSLEGIKTLY---DNVDVVTIRENTEGEYSGIEHEIVDGVVQSIK 352
+R E DLY N+RP K T + +D+V +RENTEG Y+G + G Q I
Sbjct: 91 KMRFELDLYVNLRPVKLYHPRLTPLKGKNKIDIVFVRENTEGLYAGAGGFLRKGTPQEIA 150
Query: 353 ----LITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
+ T RV FAF++A+ + RKKVT V KAN++
Sbjct: 151 VQEMINTRFGVERVIRFAFEYAKRSGRKKVTLVDKANVL 189
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 67.3 bits (157), Expect = 2e-10
Identities = 46/121 (38%), Positives = 67/121 (55%), Gaps = 11/121 (9%)
Frame = +2
Query: 128 LKGPLMTPVGK--GYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGE 301
L G + +P K GY S +ALR+E L+ANVRP KS+EG K +D+V +RENTE
Sbjct: 92 LFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEGEKG--KPIDMVIVRENTEDL 149
Query: 302 YSGIEHEIVD-----GVVQSIKLITEEASTRVAEFAFQFARENKRKK----VTAVHKANI 454
Y IE +D V + K I+E A+ R+A A A + + + +T HK+N+
Sbjct: 150 YIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIALKRLQTRGQATLTVTHKSNV 209
Query: 455 M 457
+
Sbjct: 210 L 210
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 66.9 bits (156), Expect = 3e-10
Identities = 53/168 (31%), Positives = 75/168 (44%), Gaps = 15/168 (8%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTP--VGKGYRSL 175
+ A +P +E D +P + + A L G + +P GYRS
Sbjct: 27 VLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAADAILFGAVASPGYPVAGYRSP 86
Query: 176 NLALRKEFDLYANVRPC---KSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQ- 343
+ LR+E DLYAN+RP G VD+V +RENTE Y+G E DG
Sbjct: 87 IVRLRRELDLYANIRPVFDDLPENGSNPRRRKVDLVVVRENTEDVYAGRERVEDDGATAI 146
Query: 344 SIKLITEEASTRVAEFAFQFARENKRK---------KVTAVHKANIMR 460
+ ++IT AS R+ A AR + +VT VHKAN++R
Sbjct: 147 AERVITRRASARIMRVACDLARARRSARNGSDAPPGRVTVVHKANVLR 194
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 64.9 bits (151), Expect = 1e-09
Identities = 38/102 (37%), Positives = 54/102 (52%), Gaps = 9/102 (8%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGIKTLYDN-----VDVVTIRENTEGEYS---GIEHEIVDG 334
L R+EFD Y N+RP + G+ N +D V +RENTEGEYS GI E +
Sbjct: 95 LKFRREFDQYVNIRPVRLFPGVPCALANRKVGDIDFVVVRENTEGEYSSLGGIMFENTEN 154
Query: 335 -VVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
+V + T R+ ++AF A + +RK VT+ K+N M
Sbjct: 155 EIVIQESIFTRRGVDRILKYAFDLAEKRERKHVTSATKSNGM 196
>UniRef50_A7GLU7 Cluster: Tartrate dehydrogenase; n=3; Bacteria|Rep:
Tartrate dehydrogenase - Bacillus cereus subsp.
cytotoxis NVH 391-98
Length = 364
Score = 64.1 bits (149), Expect = 2e-09
Identities = 44/136 (32%), Positives = 74/136 (54%), Gaps = 10/136 (7%)
Frame = +2
Query: 80 GIPQ-KAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEG----I 244
GI Q KA D++ +G G P L L +R+ FD Y N+RP L+G +
Sbjct: 61 GIEQLKAFDAIYLGAVGFPG---VPDYISLWDLLLRIRQSFDQYVNIRPVTLLKGAPCPL 117
Query: 245 KTLY-DNVDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFAR 409
K + +++D++ IREN+EGEY+G + G VV + + + + R+ +AF+ AR
Sbjct: 118 KDVKREDIDMLFIRENSEGEYAGAGDWLYKGKEHEVVLQNSVFSRKGTERIIRYAFEIAR 177
Query: 410 ENKRKKVTAVHKANIM 457
+ +RK +T++ K N +
Sbjct: 178 K-ERKSLTSISKGNAL 192
>UniRef50_Q44471 Cluster: Probable tartrate
dehydrogenase/decarboxylase ttuC; n=66; cellular
organisms|Rep: Probable tartrate
dehydrogenase/decarboxylase ttuC - Agrobacterium vitis
(Rhizobium vitis)
Length = 364
Score = 63.7 bits (148), Expect = 2e-09
Identities = 40/105 (38%), Positives = 55/105 (52%), Gaps = 9/105 (8%)
Frame = +2
Query: 173 LNLALRKEFDLYANVRPCKSLEGIKTLYDN-----VDVVTIRENTEGEYSG----IEHEI 325
L L + + FD YANVRP K L GI N +D V +REN+EGEYSG +
Sbjct: 90 LRLPICQGFDQYANVRPTKILPGITPPLRNCGPGDLDWVIVRENSEGEYSGHGGRAHRGL 149
Query: 326 VDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+ V + + T TR+ +AF+ A+ RK +T V K+N R
Sbjct: 150 PEEVGTEVAIFTRVGVTRIMRYAFKLAQARPRKLLTVVTKSNAQR 194
>UniRef50_Q13FQ0 Cluster: Tartrate dehydrogenase; n=3;
Proteobacteria|Rep: Tartrate dehydrogenase -
Burkholderia xenovorans (strain LB400)
Length = 364
Score = 62.9 bits (146), Expect = 4e-09
Identities = 36/105 (34%), Positives = 56/105 (53%), Gaps = 9/105 (8%)
Frame = +2
Query: 173 LNLALRKEFDLYANVRPCKSLEGI-----KTLYDNVDVVTIRENTEGEYSGIEHEIVDG- 334
L L + + FD YANVRP + L GI + +++ V +REN+EGEYSG+ + G
Sbjct: 90 LRLKICQGFDQYANVRPTRILPGIDGPLKRCKPGDLNWVIVRENSEGEYSGVGGRVHQGH 149
Query: 335 ---VVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
+ ++T R+ FAF+ A+ RK +T + K+N R
Sbjct: 150 PIEAATDVSILTRAGVERIMRFAFRLAQSRPRKLLTVITKSNAQR 194
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 62.1 bits (144), Expect = 7e-09
Identities = 36/98 (36%), Positives = 54/98 (55%), Gaps = 7/98 (7%)
Frame = +2
Query: 188 RKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHE-------IVDGVVQS 346
RK DLYANVRP ++ G + D+V +RENTEG Y+ E + V S
Sbjct: 104 RKNLDLYANVRPARTYAGRPGRLGDFDLVVVRENTEGFYADRNMEQGNGEMLVTPDVAIS 163
Query: 347 IKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
++ IT R+A A + A + +R+ +T VHKAN+++
Sbjct: 164 LRRITRACCERIAHAACRLAMK-RRRHLTIVHKANVLK 200
>UniRef50_Q8FPV5 Cluster: 3-isopropylmalate dehydrogenase; n=50;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Corynebacterium efficiens
Length = 340
Score = 61.7 bits (143), Expect = 1e-08
Identities = 42/126 (33%), Positives = 64/126 (50%), Gaps = 7/126 (5%)
Frame = +2
Query: 101 DSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VDV 271
D++ IG G + P G R L L LR D + N+RP K EG+++ N +D
Sbjct: 61 DAILLGAIGAPGSV--PPGVLERGLLLKLRFALDHHVNLRPSKLYEGVESPLKNPGEIDF 118
Query: 272 VTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFARENKRKKVTAV 439
V +RE TEG Y+G I G + T + RV +AF+ A +++R+ +T V
Sbjct: 119 VVVREGTEGAYTGNGGAIRVGTPHETANETSVNTRYGAERVIRYAFELA-QSRRRHLTLV 177
Query: 440 HKANIM 457
HK N++
Sbjct: 178 HKTNVL 183
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 60.9 bits (141), Expect = 2e-08
Identities = 47/156 (30%), Positives = 74/156 (47%), Gaps = 13/156 (8%)
Frame = +2
Query: 23 PIEWEEVDVTAVRG---PDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRK 193
PIEW D A G PD + +D++ +G P P + R+
Sbjct: 43 PIEWASCDYYAKHGQMMPDD-WKTQLSGMDALLFGAVGW--PETVPDHISLWGSLIKFRR 99
Query: 194 EFDLYANVRPCKSLEGIKTLY-----DNVDVVTIRENTEGEYSGIEHEIVDG-----VVQ 343
EFD Y N+RP + +G+ ++D + +RENTEGEYS + + +G VVQ
Sbjct: 100 EFDQYVNLRPARLFDGVPCPLAGRKAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQ 159
Query: 344 SIKLITEEASTRVAEFAFQFARENKRKKVTAVHKAN 451
+ T + RV +FAF+ A + + K++T K+N
Sbjct: 160 Q-AVFTRHGTERVLKFAFELA-QRRAKRLTVATKSN 193
>UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-isopropylmalate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 478
Score = 60.5 bits (140), Expect = 2e-08
Identities = 40/110 (36%), Positives = 54/110 (49%), Gaps = 7/110 (6%)
Frame = +2
Query: 149 PVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN---VDVVTIRENTEGEYSGIEH 319
P G R L L LR E D Y N+RP + G+ + N VD V +RE TEG Y+G
Sbjct: 212 PPGILERGLLLRLRFELDHYVNLRPSRIFPGVASPLANPGEVDFVVVREGTEGPYTGNGG 271
Query: 320 EIVDG----VVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
+ G + + + T RV AF A+ RKK+T VHK N++
Sbjct: 272 ALRVGTPHEIATEVSVNTAFGVERVVRDAFARAQRRPRKKLTLVHKTNVL 321
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 60.1 bits (139), Expect = 3e-08
Identities = 40/145 (27%), Positives = 72/145 (49%), Gaps = 3/145 (2%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMT--PVGKGYRSL 175
+F + VP+++E V V + + AI ++ N + LKG + T + ++S
Sbjct: 72 LFRFSCVPVDFEVVHVNSSSTSEDDIS---NAIMAIRRNGVALKGNIETNHTMPPNHKSR 128
Query: 176 NLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKL 355
N LR DLYANV C+SL G++T + N+D++ I E +E E+E + + +++
Sbjct: 129 NNLLRTSLDLYANVMHCQSLPGVQTRHKNIDIIIILEKSEFSALLAENEKIKVELLQLRI 188
Query: 356 -ITEEASTRVAEFAFQFARENKRKK 427
+ + + R A+ E R K
Sbjct: 189 QLADVINKRRADIILDLNIEKSRVK 213
>UniRef50_Q8U299 Cluster: 3-isopropylmalate dehydrogenase 2; n=3;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
2 - Pyrococcus furiosus
Length = 355
Score = 59.3 bits (137), Expect = 5e-08
Identities = 38/100 (38%), Positives = 51/100 (51%), Gaps = 7/100 (7%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGIKTLY---DNVDVVTIRENTEGEYSGIEHEIVDGVVQSI 349
L LR DLY N+RP K T + +D+V IRENTEG Y+G + G +
Sbjct: 89 LKLRFSLDLYVNLRPVKLYHPKLTPLKGKEKIDMVFIRENTEGLYAGAGGFLRKGTPHEV 148
Query: 350 KLI----TEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
+ T R FAF++A+ RKKVT V KAN++
Sbjct: 149 AIQEMINTRFGVERTIRFAFEYAKTKGRKKVTLVDKANVL 188
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 56.4 bits (130), Expect = 4e-07
Identities = 39/134 (29%), Positives = 66/134 (49%), Gaps = 11/134 (8%)
Frame = +2
Query: 92 KAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN--- 262
+ D++ G+ G + + L LR + DL+ANVRP K +G+ +
Sbjct: 64 RTADAILHGAAGIPGVVHPDGTEAGLDFTLTLRFKLDLFANVRPIKLYKGVPSPLGRPGP 123
Query: 263 VDVVTIRENTEGEYS--GIEHEIVDGVVQSIKLITEEASTRVAEFAFQFAR------ENK 418
+D V +REN+EG Y+ G + + V + T + R+ FAF+ AR ++
Sbjct: 124 IDYVIVRENSEGLYAARGAGALLREEVAVDTLVQTRKGVERIVRFAFELARTRNGSPKDG 183
Query: 419 RKKVTAVHKANIMR 460
R++VT KAN++R
Sbjct: 184 RRRVTCCDKANVLR 197
>UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Rhodobacterales|Rep: 3-isopropylmalate dehydrogenase -
Stappia aggregata IAM 12614
Length = 369
Score = 56.4 bits (130), Expect = 4e-07
Identities = 40/109 (36%), Positives = 60/109 (55%), Gaps = 14/109 (12%)
Frame = +2
Query: 170 SLNLALRKEFDLYANVRPCKSLEGI-KTLYD----NVDVVTIRENTEG-EYSGIEHE--- 322
S +L LR F LYA VRP K+ + L D +D+V +RE+TEG YS H+
Sbjct: 87 SPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRAAGIDLVILRESTEGLFYSAAAHKRSL 146
Query: 323 -IVDGVVQSIKLITEEASTRVAEFAFQFARENKRK----KVTAVHKANI 454
+ D VQ + IT + +T++ FAF AR+ + + ++T V KAN+
Sbjct: 147 VVNDDEVQDVLRITRKTTTKLHRFAFNLARKRRERGHPGRLTCVDKANV 195
>UniRef50_Q8XSY8 Cluster: Probable 3-isopropylmalate dehydrogenase
oxidoreductase protein; n=1; Ralstonia solanacearum|Rep:
Probable 3-isopropylmalate dehydrogenase oxidoreductase
protein - Ralstonia solanacearum (Pseudomonas
solanacearum)
Length = 365
Score = 55.6 bits (128), Expect = 7e-07
Identities = 41/108 (37%), Positives = 58/108 (53%), Gaps = 10/108 (9%)
Frame = +2
Query: 158 KGYRSLNLALRKEFDLYANVRPCKS---LEGIKTLYDNVDVVTIRENTEGEYSGIE---- 316
KG R+++ R DLYANVRP ++ L +D+V +RE TEG Y
Sbjct: 82 KGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRTMDLVIMREATEGFYPDRNMTKG 141
Query: 317 -HEIVDG--VVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKAN 451
E++ + S++ IT S R+A AF+ A + K KKVTA+HKAN
Sbjct: 142 WAELMPSPDMAISLRKITRHCSERIARRAFELAMKRK-KKVTAIHKAN 188
>UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyces
lasaliensis|Rep: Putative dehydrogenase - Streptomyces
lasaliensis
Length = 362
Score = 54.4 bits (125), Expect = 2e-06
Identities = 47/133 (35%), Positives = 65/133 (48%), Gaps = 12/133 (9%)
Frame = +2
Query: 98 IDSVNANKIGLKGPLMTP-VGK-GY-RSLNLALRKEFDLYANVRPCKSL-EGIKTLYDN- 262
+D + +++ L G + P +G Y R + LR E DLY N RP + + + L D
Sbjct: 74 LDRIRSSEAALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDPA 133
Query: 263 ---VDVVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFARENKR 421
+D V +RENTEG YSGI G + + L T +RV EFAF A R
Sbjct: 134 RRAIDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAA----R 189
Query: 422 KKVTAVHKANIMR 460
+ V V KAN +R
Sbjct: 190 RSVCLVDKANAVR 202
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 54.0 bits (124), Expect = 2e-06
Identities = 47/161 (29%), Positives = 73/161 (45%), Gaps = 8/161 (4%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTP-VGKGYRSLN 178
+F++ +PI+ + VD +P ID V L G L P Y +L
Sbjct: 32 MFQSLNLPIQRDYVDWGIQHYLKTGKVVPIDYIDQVKQYDAILLGSLGDPRTLPDYVTLE 91
Query: 179 --LALRKEFDLYANVRPCKSLEGIKTLYDN--VDVVTIRENTEGEYSGIEHEIVDGVVQS 346
+ +R++ D + +RP K GI T +DV+ +REN+EGEYS I G +
Sbjct: 92 PLIQMRQQLDQFLCLRPAKHFPGIPTPLKKCEIDVLVVRENSEGEYSNIGGIFKSGTPEE 151
Query: 347 IKLITEEASTRVAEFAFQFARENKRKK---VTAVHKANIMR 460
+ + S R E ++A E RK+ VT K+N M+
Sbjct: 152 FAIESAVHSRRGLERVIRYAFEASRKRRNHVTLATKSNAMK 192
>UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila
melanogaster|Rep: IP13250p - Drosophila melanogaster
(Fruit fly)
Length = 475
Score = 54.0 bits (124), Expect = 2e-06
Identities = 24/87 (27%), Positives = 50/87 (57%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLI 358
L + + DLY +S G K + VD+ I +N G ++ +E+ V+GVV+++ ++
Sbjct: 132 LKICNDLDLYVFKTRTRSFPGFKCRFPGVDIQLIGQNNMGIFNELEYSPVEGVVEALSVV 191
Query: 359 TEEASTRVAEFAFQFARENKRKKVTAV 439
+++ + + +AF+ A + RK+VT +
Sbjct: 192 SQKGNDKYLRYAFKAAAKAGRKRVTLI 218
>UniRef50_Q67LW7 Cluster: Tartrate dehydrogenase; n=2; Bacteria|Rep:
Tartrate dehydrogenase - Symbiobacterium thermophilum
Length = 359
Score = 53.6 bits (123), Expect = 3e-06
Identities = 34/102 (33%), Positives = 53/102 (51%), Gaps = 9/102 (8%)
Frame = +2
Query: 173 LNLALRKEFDLYANVRPCKSLEGIKTLY-----DNVDVVTIRENTEGEYSGIEHEIVDG- 334
L L +R+ F+ Y N+RP + L G+ + +V+ V IRENTEGEYS + + G
Sbjct: 90 LLLPIRRGFEQYVNLRPVRILRGVVSPLRGRNPGDVNFVCIRENTEGEYSNMGGRLHAGL 149
Query: 335 ---VVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKAN 451
VV + T + R+ +A+Q A RK++ K+N
Sbjct: 150 PHEVVVQNTVFTRVGTERIIRYAYQLAANAPRKRLCGATKSN 191
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 53.2 bits (122), Expect = 3e-06
Identities = 37/133 (27%), Positives = 65/133 (48%), Gaps = 10/133 (7%)
Frame = +2
Query: 83 IPQKAIDSV---NANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTL 253
+P+ A++++ +A G G P L + +RK F Y N RP KSL GI +
Sbjct: 57 MPEDALETLQKYDAILFGAIGDARVPDDVTVWELIMPIRKNFQQYVNFRPIKSLPGISSP 116
Query: 254 Y---DNVDVVTIRENTEGEYSGIEHEIVDGVVQSI----KLITEEASTRVAEFAFQFARE 412
+++D V REN EGEYS + Q + ++T ++ A ++A++
Sbjct: 117 LAGGNDIDFVIFRENAEGEYSDSGGRLYQQQPQEMTIQNTIMTRIGIEKIVRAACEYAQQ 176
Query: 413 NKRKKVTAVHKAN 451
+ + K+T+ K+N
Sbjct: 177 HGKTKLTSATKSN 189
>UniRef50_Q8DTG3 Cluster: 3-isopropylmalate dehydrogenase; n=41;
Bacilli|Rep: 3-isopropylmalate dehydrogenase -
Streptococcus mutans
Length = 344
Score = 52.8 bits (121), Expect = 5e-06
Identities = 33/100 (33%), Positives = 52/100 (52%), Gaps = 7/100 (7%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGIKTL-------YDNVDVVTIRENTEGEYSGIEHEIVDGV 337
LA+RKE +L+AN+RP + + ++ L VD V +RE T G Y G +H + +
Sbjct: 90 LAIRKELNLFANIRPVRIFDALRHLSPLKAERIAGVDFVVVRELTGGIYFG-QHTLTENS 148
Query: 338 VQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
I + R+ AF AR + KKVT++ K N++
Sbjct: 149 ACDINEYSASEIRRIMRKAFAIAR-GRSKKVTSIDKQNVL 187
>UniRef50_Q8YCX4 Cluster: 3-isopropylmalate dehydrogenase; n=126;
Bacteria|Rep: 3-isopropylmalate dehydrogenase - Brucella
melitensis
Length = 370
Score = 52.8 bits (121), Expect = 5e-06
Identities = 37/106 (34%), Positives = 57/106 (53%), Gaps = 12/106 (11%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGI-------KTLYDNVDVVTIRENTEGEYSGIEHEIVD-G 334
L LRK+ LYAN+RP + + + +D++ +RE T G Y G EI+D G
Sbjct: 94 LRLRKDMQLYANLRPAICYPALAHSSSLKPEVIEGLDILILRELTGGVYFGEPKEIIDLG 153
Query: 335 VVQSIKLITEEAST----RVAEFAFQFARENKRKKVTAVHKANIMR 460
Q + T+ T R+A+ AF+ AR +R KVT++ K N+M+
Sbjct: 154 NGQKRGIDTQVYDTYEIERIADVAFELAR-TRRNKVTSMEKRNVMK 198
>UniRef50_Q89RJ1 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Alphaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Bradyrhizobium japonicum
Length = 368
Score = 52.4 bits (120), Expect = 6e-06
Identities = 34/104 (32%), Positives = 55/104 (52%), Gaps = 10/104 (9%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGIKTLY-----DNVDVVTIRENTEGEYSGIEHEIVDGV-V 340
+ LR FDLYA VRP + + G+ + +D+V IRE+TEG ++ + +V
Sbjct: 104 IELRFIFDLYAGVRPARLIPGVPSPIVGADTRGIDLVVIRESTEGLFASMGKGVVTHEDA 163
Query: 341 QSIKLITEEASTRVAEFAFQFARENKRK----KVTAVHKANIMR 460
+ +IT S R+ EF+F+ A K + +T V KAN+ +
Sbjct: 164 RETMVITRRTSERLFEFSFRLAARRKARGKPGMLTCVDKANVFK 207
>UniRef50_Q81T67 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacillus cereus group|Rep: 3-isopropylmalate
dehydrogenase - Bacillus anthracis
Length = 354
Score = 51.6 bits (118), Expect = 1e-05
Identities = 42/134 (31%), Positives = 59/134 (44%), Gaps = 9/134 (6%)
Frame = +2
Query: 83 IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLN----LALRKEFDLYANVRPCKSLEGIKT 250
+PQ+ + + A+ L G + P G + LALRK ++ANVRP
Sbjct: 55 LPQRTLAACLASDAVLLGAVGGPRWDGAKERPEKGLLALRKGLGVFANVRPVTVESATAH 114
Query: 251 LY-----DNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFAREN 415
L D +D V +RE T G Y E D V R+ AFQ A +
Sbjct: 115 LSPLKKADEIDFVVVRELTGGIYFSYPKERTDEVATDTLTYHRHEIERIVSCAFQLASKR 174
Query: 416 KRKKVTAVHKANIM 457
K KKVT++ KAN++
Sbjct: 175 K-KKVTSIDKANVL 187
>UniRef50_Q8A6M0 Cluster: 3-isopropylmalate dehydrogenase; n=42;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Bacteroides thetaiotaomicron
Length = 353
Score = 51.2 bits (117), Expect = 1e-05
Identities = 32/100 (32%), Positives = 55/100 (55%), Gaps = 7/100 (7%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGI-------KTLYDNVDVVTIRENTEGEYSGIEHEIVDGV 337
LA+RK+ L+AN+RP ++ + + L +N D + IRE T G Y G +++ D
Sbjct: 94 LAMRKKLGLFANIRPVQTFKCLIHKSPLRAELVENADFICIRELTGGMYFGEKYQDNDKA 153
Query: 338 VQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
+ T R+ + AF++A + +RK +T V KAN++
Sbjct: 154 YDT-NYYTRPEIERILKVAFEYAMK-RRKHLTVVDKANVL 191
>UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenase;
n=1; Plesiocystis pacifica SIR-1|Rep: Probable
3-isopropylmalate dehydrogenase - Plesiocystis pacifica
SIR-1
Length = 368
Score = 50.8 bits (116), Expect = 2e-05
Identities = 45/138 (32%), Positives = 68/138 (49%), Gaps = 23/138 (16%)
Frame = +2
Query: 125 GLKGPLMTPVGK--GYRSLNLALRKEFDLYANVRPCKSLEGI--------KTLYD--NVD 268
G GP++ K G+ + + R +LYANVRP K G+ K +++ VD
Sbjct: 65 GTGGPVLMKDNKMAGFSPV-IGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAGKVD 123
Query: 269 VVTIRENTEGEYSGIEHEIVDG----VVQSIKLITEEASTRVAEFAFQFA-RENK----- 418
+V IRENTEG Y+ ++ G V ++IT A +V AF+ R NK
Sbjct: 124 MVIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKGAPKD 183
Query: 419 -RKKVTAVHKANIMR*CQ 469
+ +VTA+ K N++ CQ
Sbjct: 184 GKLRVTAIIKDNVLHGCQ 201
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 50.8 bits (116), Expect = 2e-05
Identities = 29/84 (34%), Positives = 52/84 (61%), Gaps = 2/84 (2%)
Frame = +2
Query: 2 IFEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVG-KG-YRSL 175
+F+AA VP+E++E ++ V+ + + Q + S+ NK+ + G + TP+ KG S
Sbjct: 38 VFKAASVPVEFQEHHLSEVQNMASEEKLEQ-VLSSMKENKVAIIGKIHTPMEYKGELASY 96
Query: 176 NLALRKEFDLYANVRPCKSLEGIK 247
++ LR++ DL+ANV KSL G++
Sbjct: 97 DMRLRRKLDLFANVIHVKSLPGVQ 120
>UniRef50_Q7UTP0 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 364
Score = 50.4 bits (115), Expect = 2e-05
Identities = 42/137 (30%), Positives = 63/137 (45%), Gaps = 12/137 (8%)
Frame = +2
Query: 83 IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLA----LRKEFDLYANVRPCKSLEGIKT 250
+PQ A D+ A+ L G + P + +A LR+ LY VRP + T
Sbjct: 58 LPQSAYDACLASDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADT 117
Query: 251 LYDN-----VDVVTIRENTEGEYSGIE--HEIVDGVVQSIKLITEEASTRVAEFAFQFAR 409
+D V +RE+TEG + G + ++ ++ IT AS RV AF+ AR
Sbjct: 118 PLKGHGPGEIDFVLVRESTEGLFYGRDAIADLEADEATNLLRITRSASERVCRLAFETAR 177
Query: 410 ENKRKK-VTAVHKANIM 457
KK VT + KAN++
Sbjct: 178 RRDGKKTVTLIDKANVL 194
>UniRef50_Q1IZK2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Deinococcus geothermalis (strain DSM 11300)
Length = 351
Score = 49.6 bits (113), Expect = 4e-05
Identities = 34/100 (34%), Positives = 51/100 (51%), Gaps = 7/100 (7%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGIK-------TLYDNVDVVTIRENTEGEYSGIEHEIVDGV 337
LALR+ YAN+RP + L G++ L VD++ +RE G Y + +I
Sbjct: 91 LALRRALGCYANLRPVRVLPGLEHLSPLKPELARGVDILIVRELLGGIYFDGDRKIEGDT 150
Query: 338 VQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
+ T RVA AF +A E +R +VT+V KAN++
Sbjct: 151 AYNTMRYTTPEVERVARVAF-WAAEQRRGRVTSVDKANVL 189
>UniRef50_Q03UM1 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Leuconostocaceae|Rep: 3-isopropylmalate dehydrogenase -
Leuconostoc mesenteroides subsp. mesenteroides (strain
ATCC 8293 /NCDO 523)
Length = 357
Score = 49.2 bits (112), Expect = 6e-05
Identities = 42/158 (26%), Positives = 69/158 (43%), Gaps = 7/158 (4%)
Frame = +2
Query: 5 FEAAKVPIEWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLA 184
+E P + +D P + ++A D+V + IG GP + L
Sbjct: 38 YELIDAPFGGDGIDRAGDPLPQSTIDVSKQA-DAVLLSAIG--GPKWDNAPRRPEQGLLE 94
Query: 185 LRKEFDLYANVRPCK------SLEGIKTLY-DNVDVVTIRENTEGEYSGIEHEIVDGVVQ 343
+R + +L+AN+RP K +K Y +N D V +RE T G Y G ++
Sbjct: 95 IRSKLNLFANIRPTKVTAAQIDRSPLKPEYVENTDFVIVRELTSGAYFGKPRKLEAHQAI 154
Query: 344 SIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
+EE TR+ F+ A + + K VT V K+N++
Sbjct: 155 DTMYYSEEEVTRIMHQGFKMA-QKRNKHVTIVDKSNVL 191
>UniRef50_Q05FQ8 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Candidatus Carsonella ruddii PV|Rep: 3-isopropylmalate
dehydrogenase - Carsonella ruddii (strain PV)
Length = 349
Score = 48.8 bits (111), Expect = 7e-05
Identities = 29/101 (28%), Positives = 55/101 (54%), Gaps = 8/101 (7%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEY----SGIEHEIVDGV--- 337
L LRK+F+ + N+RP IK + N+D++ +RE G Y G +I++ +
Sbjct: 89 LKLRKKFNFFTNIRP------IKCPFKNIDIIIVRELNGGIYYGKPKGFSKQIINQIPTW 142
Query: 338 -VQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
+ K+ E+ R+A +F A N++KK+ ++ K+N++
Sbjct: 143 YAYNTKIYNEQEIIRLARISFNLAL-NRKKKLCSIDKSNVL 182
>UniRef50_Q8E9N3 Cluster: 3-isopropylmalate dehydrogenase; n=148;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Shewanella oneidensis
Length = 364
Score = 48.4 bits (110), Expect = 1e-04
Identities = 48/163 (29%), Positives = 76/163 (46%), Gaps = 19/163 (11%)
Frame = +2
Query: 26 IEWEEVDVTAVRGPDGKFGIPQ------KAIDSVNANKIG-LKGPLMTPVGKGYRSLNLA 184
IE+ E DV + + +P+ +A D++ +G K + P + R L
Sbjct: 36 IEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLP 95
Query: 185 LRKEFDLYANVRPCK---SLEGIKTLYDNV-----DVVTIRENTEGEY----SGIEHEIV 328
LR F+L+ N+RP K LE + L ++ DV+ +RE T G Y G + E
Sbjct: 96 LRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGE 155
Query: 329 DGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
+ +R+A AF+ AR +RKKVT+V KAN++
Sbjct: 156 SEEAFDTMRYSRREISRIARIAFEAAR-GRRKKVTSVDKANVL 197
>UniRef50_Q7VH33 Cluster: 3-isopropylmalate dehydrogenase; n=11;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Helicobacter hepaticus
Length = 357
Score = 47.6 bits (108), Expect = 2e-04
Identities = 35/105 (33%), Positives = 56/105 (53%), Gaps = 12/105 (11%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGI--------KTLYDNVDVVTIRENTEGEYSGIEHEI--V 328
L LRKE L+AN+RP L + + L +D + +RE G Y G EH++ +
Sbjct: 93 LTLRKELGLFANIRPATLLPQLSKASPLKDEILNRGIDFIIVRELIGGVYFG-EHKLEEI 151
Query: 329 DGVVQSIKLITEEAS--TRVAEFAFQFARENKRKKVTAVHKANIM 457
+G + +T AS +A+ AF AR N++K++ V KAN++
Sbjct: 152 NGEKVASDAMTYSASQIESIAKVAFNIAR-NRKKEIVCVDKANVL 195
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 47.2 bits (107), Expect = 2e-04
Identities = 41/122 (33%), Positives = 53/122 (43%), Gaps = 9/122 (7%)
Frame = +2
Query: 122 IGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDN--VDVVTIRENTE 295
+GL G + P G L LR D YANVRP L G+ VD V +RENTE
Sbjct: 78 VGLPG-VRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTAVDYVIVRENTE 136
Query: 296 GEYSGIEHEI-VDGVVQSIKLITEEASTRVAEFAFQFARENKR------KKVTAVHKANI 454
G Y + D L+T RV AF+ A ++VT V K+N+
Sbjct: 137 GLYLSRGRGVGNDRACADQLLMTRHGVERVVVHAFELATRRTGAPADGVRRVTCVDKSNV 196
Query: 455 MR 460
+R
Sbjct: 197 LR 198
>UniRef50_Q0W5L4 Cluster: 3-isopropylmalate dehydrogenase; n=10;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 380
Score = 45.6 bits (103), Expect = 7e-04
Identities = 33/129 (25%), Positives = 62/129 (48%), Gaps = 32/129 (24%)
Frame = +2
Query: 167 RSLNLALRKEFDLYANVRPCKSLEGIKT-----LYDNVDVVTIRENTEGEYSGI------ 313
+ + L +R +D Y N+RP K +EG++T ++D +RENTE Y GI
Sbjct: 88 KGILLTMRFYYDQYVNLRPVKLMEGVETPLKGKTAADIDFYVVRENTEDFYVGIGGRSKK 147
Query: 314 -----EHEIV----------------DGVVQSIKLITEEASTRVAEFAFQFARENKRKKV 430
E E++ D + + ++++E + R+ E++F A +K +
Sbjct: 148 GTSKQELEVIRQMYSVKFGLDVETDSDEIAYQLGVVSKEGAKRIIEYSFDLANSRPKKHL 207
Query: 431 TAVHKANIM 457
++V KAN++
Sbjct: 208 SSVDKANVL 216
>UniRef50_Q48806 Cluster: Protein dlpA; n=4; Legionella
pneumophila|Rep: Protein dlpA - Legionella pneumophila
subsp. pneumophila (strain Philadelphia 1 /ATCC 33152 /
DSM 7513)
Length = 615
Score = 45.2 bits (102), Expect = 0.001
Identities = 35/118 (29%), Positives = 58/118 (49%), Gaps = 19/118 (16%)
Frame = +2
Query: 164 YRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIE--------H 319
Y S + LR+ DL+ANVRPC S++ + + IREN+EG Y G + H
Sbjct: 97 YVSPVIQLRQGLDLFANVRPCFSIDDQSKPF---NFCIIRENSEGLYCGFDYFPLPKAIH 153
Query: 320 EIV-----------DGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
++ D +++L ++ TR+ +FAF+ A + +VT K N++R
Sbjct: 154 SLLAESQHWQTIPADEASCALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLR 211
>UniRef50_Q300E7 Cluster: Isocitrate/isopropylmalate dehydrogenase;
n=1; Streptococcus suis 89/1591|Rep:
Isocitrate/isopropylmalate dehydrogenase - Streptococcus
suis 89/1591
Length = 207
Score = 44.8 bits (101), Expect = 0.001
Identities = 30/96 (31%), Positives = 44/96 (45%), Gaps = 7/96 (7%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGIKTL-------YDNVDVVTIRENTEGEYSGIEHEIVDGV 337
L LRKE L+AN+RP K + +K D VD+V +RE T G Y G +H +
Sbjct: 91 LQLRKELGLFANIRPVKIFDSLKDYSPLKADRLDGVDLVMVRELTGGIYFG-KHILETYQ 149
Query: 338 VQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHK 445
E RV AF A++ ++K + +
Sbjct: 150 ASDSNTYQAEEIERVVRSAFDLAQKRQKKSPALISR 185
>UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 173
Score = 44.4 bits (100), Expect = 0.002
Identities = 34/82 (41%), Positives = 40/82 (48%)
Frame = -3
Query: 246 LIPSKLLQGLTLAYKSNSFLRAKLSDL*PLPTGVIRGPFKPILLAFTESIAFWGIPNLPS 67
L P L A SNSFL A +DL P GV + PF P L F +S A P S
Sbjct: 7 LTPGMFLIKTNEAKISNSFLNATFNDLPDDPVGVNKIPFNPTLFLFNDSTAS-ATPVPLS 65
Query: 66 GPLTAVTSTSSHSIGTLAASKI 1
P TST SHS+GT + K+
Sbjct: 66 KP---ETSTVSHSMGTFSDLKM 84
>UniRef50_Q89XA0 Cluster: 3-isopropylmalate dehydrogenase 1; n=3;
Bacteria|Rep: 3-isopropylmalate dehydrogenase 1 -
Bradyrhizobium japonicum
Length = 379
Score = 44.4 bits (100), Expect = 0.002
Identities = 41/123 (33%), Positives = 61/123 (49%), Gaps = 15/123 (12%)
Frame = +2
Query: 134 GPLMTPVGKGYRSLN--LALRKEFDLYANVRPCKSLEGI-------KTLYDNVDVVTIRE 286
GP T V R L+LR ++DLYAN+RP + + + +VD + IRE
Sbjct: 81 GPETTEVPPAARKAGSLLSLRSKYDLYANLRPIVANPALADSAPLKAAVLKDVDFIIIRE 140
Query: 287 NTEGEY----SGIEHEIVDGVVQ--SIKLITEEASTRVAEFAFQFARENKRKKVTAVHKA 448
T G Y GIE + DG + + + T RVA AF+ AR ++ +V +V KA
Sbjct: 141 LTSGIYFGEPRGIE-TLPDGQRRGFNTQQYTTSQIRRVARTAFELAR-TRKGRVCSVDKA 198
Query: 449 NIM 457
N++
Sbjct: 199 NVL 201
>UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: 3-isopropylmalate
dehydrogenase - Victivallis vadensis ATCC BAA-548
Length = 369
Score = 43.6 bits (98), Expect = 0.003
Identities = 28/96 (29%), Positives = 47/96 (48%), Gaps = 9/96 (9%)
Frame = +2
Query: 167 RSLNLALRKEFDLYANVRPCKSLEGIKTLYDN-----VDVVTIRENTEGEYSG----IEH 319
+ + L LR + D Y N+RP K G++T N +D V +REN+ G Y+G ++
Sbjct: 88 KGILLKLRFDLDQYINLRPVKLFPGVETPLANKKPEDIDYVVVRENSGGVYTGMGGNVQI 147
Query: 320 EIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKK 427
+ + V + T R +FAF+ A + K+
Sbjct: 148 DTPEEVACQNWIYTRSQVDRCLKFAFELAEKRHTKE 183
>UniRef50_Q1IMD5 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Acidobacteria bacterium Ellin345|Rep: 3-isopropylmalate
dehydrogenase - Acidobacteria bacterium (strain
Ellin345)
Length = 403
Score = 42.7 bits (96), Expect = 0.005
Identities = 39/141 (27%), Positives = 65/141 (46%), Gaps = 33/141 (23%)
Frame = +2
Query: 137 PLMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY-----------DNVDVVTIR 283
P + G Y S + +R+ F+L +RPC S G + VDVV R
Sbjct: 85 PELRGKGLSYFSPIVTMRQLFNLDVCMRPCLSFPGNPLNFIRQTTCGGFEEPQVDVVVFR 144
Query: 284 ENTEGEYSGIE--------------HEIV--------DGVVQSIKLITEEASTRVAEFAF 397
+NTEG Y+G+E H+ + + S+++IT++ + R+ E AF
Sbjct: 145 QNTEGLYAGVEWTNPPENVRTALASHKKFAAFANTPGEELAVSVRIITKKNAQRICEAAF 204
Query: 398 QFARENKRKKVTAVHKANIMR 460
+ A++ + K VT K N++R
Sbjct: 205 KHAKKYRYKNVTICEKPNVLR 225
>UniRef50_Q12545 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Hypocreales|Rep: 3-isopropylmalate dehydrogenase -
Cephalosporium acremonium (Acremonium chrysogenum)
Length = 380
Score = 41.9 bits (94), Expect = 0.009
Identities = 42/137 (30%), Positives = 62/137 (45%), Gaps = 15/137 (10%)
Frame = +2
Query: 92 KAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVRPCK----SLEGIKTLYD 259
KA D+V IG GP V S L LR+ D +AN+RPC+ SL G + +
Sbjct: 67 KASDAVLFGSIG--GPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGASPIRE 124
Query: 260 NV----DVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFAR------ 409
+V + +REN G Y G + E D V + + T R+A + AR
Sbjct: 125 HVVKGTRFIVVRENCGGAYFGEKKEEED-VASDLWVYTRPEIERLARVSAAVARIMGRSE 183
Query: 410 -ENKRKKVTAVHKANIM 457
+N+ V + KAN++
Sbjct: 184 DDNQAATVWSADKANVL 200
>UniRef50_P04173 Cluster: 3-isopropylmalate dehydrogenase; n=41;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Saccharomyces cerevisiae (Baker's yeast)
Length = 364
Score = 41.1 bits (92), Expect = 0.015
Identities = 44/149 (29%), Positives = 60/149 (40%), Gaps = 10/149 (6%)
Frame = +2
Query: 41 VDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVR 220
+D T V PD +KA D+V +G GP L +RKE LYAN+R
Sbjct: 51 IDATGVPLPDEALEASKKA-DAVLLGAVG--GPKWGTGSVRPEQGLLKIRKELQLYANLR 107
Query: 221 PCK-------SLEGIKTLY-DNVDVVTIRENTEGEYSGIEHE-IVDGVVQSIKLITEEAS 373
PC L IK + D V +RE G Y G E DGV + T
Sbjct: 108 PCNFASDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYTVPEV 167
Query: 374 TRVAEF-AFQFARENKRKKVTAVHKANIM 457
R+ AF + + ++ KAN++
Sbjct: 168 QRITRMAAFMALQHEPPLPIWSLDKANVL 196
>UniRef50_Q2JTN8 Cluster: 3-isopropylmalate dehydrogenase; n=72;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria
bacteriumYellowstone A-Prime)
Length = 381
Score = 39.9 bits (89), Expect = 0.035
Identities = 33/105 (31%), Positives = 52/105 (49%), Gaps = 12/105 (11%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCK------SLEGIKT-LYDNVDVVTIRENTEGEYSGIEHEIVDGV 337
L LR L+AN+RP K +K + +D+V +RE T G Y G I
Sbjct: 101 LGLRAGLGLFANLRPVKIFPQLVQASSLKPEVVAGIDLVVVRELTGGIYFGQPKGIFTDA 160
Query: 338 VQSIKLI-----TEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
S + + +E R+A AF+ AR+ +R+K+ +V KAN++
Sbjct: 161 KGSRRGVNTMAYSEAEVDRIARVAFELARK-RRRKLCSVDKANVL 204
>UniRef50_UPI00003C8595 Cluster: hypothetical protein Faci_03000731;
n=1; Ferroplasma acidarmanus fer1|Rep: hypothetical
protein Faci_03000731 - Ferroplasma acidarmanus fer1
Length = 377
Score = 39.1 bits (87), Expect = 0.060
Identities = 28/98 (28%), Positives = 48/98 (48%), Gaps = 5/98 (5%)
Frame = +2
Query: 26 IEWEEVDVTAVRGPDGKFG--IPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEF 199
IEW ++ + KFG +P+ +I + I +K L K R LN LRK
Sbjct: 60 IEWHKILIGTEAYE--KFGTYVPEDSIKEIQKMYIAMKSTLNFMPDK--RDLNTILRKRL 115
Query: 200 DLYANVRPCKSLEGIK---TLYDNVDVVTIRENTEGEY 304
LY+N+R K +EG+ ++ +++ IR++T +
Sbjct: 116 GLYSNIRILKYIEGMDIPVNTFNRLNLTIIRDSTPNSH 153
>UniRef50_Q3ZXI7 Cluster: 3-isopropylmalate dehydrogenase; n=66;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Dehalococcoides sp. (strain CBDB1)
Length = 365
Score = 39.1 bits (87), Expect = 0.060
Identities = 35/105 (33%), Positives = 53/105 (50%), Gaps = 12/105 (11%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCK---SLEG---IKT-LYDNVDVVTIRENTEGEYSGIEHE---IV 328
LALRK L+AN+RP K SL IK + D + IRE T G Y +
Sbjct: 93 LALRKGLGLFANIRPVKVAPSLVNSTPIKAEIVKGTDFIFIRELTGGVYFAKPKKRWTTP 152
Query: 329 DGVVQSIKLIT--EEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
G+ ++ +T E R+ F+ A+ N++KK+ +V KAN++
Sbjct: 153 AGIRKATDSMTYSENEIERIVRVGFELAK-NRKKKLVSVDKANVL 196
>UniRef50_Q6B458 Cluster: 3-isopropylmalate dehydrogenase; n=30;
Ascomycota|Rep: 3-isopropylmalate dehydrogenase -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 382
Score = 38.3 bits (85), Expect = 0.11
Identities = 31/106 (29%), Positives = 48/106 (45%), Gaps = 13/106 (12%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCK-------SLEGIKT-LYDNVDVVTIRENTEGEYSGIEHEIVDG 334
L +RKE +LYAN+RPC L +K+ + D +RE G Y G E +
Sbjct: 106 LKIRKELNLYANLRPCNFASDSLLELSPLKSEIVKGTDFTVVRELVGGIYFGERQEQAES 165
Query: 335 VVQSIKLITEEAS----TRVAEF-AFQFARENKRKKVTAVHKANIM 457
+ TE+ S TR+ AF + N + ++ KAN++
Sbjct: 166 EDKQTAWDTEKYSTEEVTRITRMAAFMALQHNPPLPIWSLDKANVL 211
>UniRef50_Q5A9E0 Cluster: Putative uncharacterized protein; n=1;
Candida albicans|Rep: Putative uncharacterized protein -
Candida albicans (Yeast)
Length = 150
Score = 37.1 bits (82), Expect = 0.24
Identities = 22/45 (48%), Positives = 26/45 (57%)
Frame = -3
Query: 303 YSPSVFSLIVTTSTLSYSVLIPSKLLQGLTLAYKSNSFLRAKLSD 169
Y SVFS +T ST + IPS L G TLAYK N FL A + +
Sbjct: 2 YKSSVFSRTITIST---GLPIPSTDLTGSTLAYKPNFFLNATIGE 43
>UniRef50_Q4P2R4 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 363
Score = 36.7 bits (81), Expect = 0.32
Identities = 22/56 (39%), Positives = 31/56 (55%), Gaps = 8/56 (14%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCK-------SLEGIKT-LYDNVDVVTIRENTEGEYSGIEHE 322
L +RK +LYANVRP K L +K + V+++T+REN G Y G + E
Sbjct: 103 LRMRKHLNLYANVRPAKIISERQLELSSLKEHVVRGVNIITLRENAGGIYFGRKQE 158
>UniRef50_Q12592 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Ascomycota|Rep: 3-isopropylmalate dehydrogenase -
Candida maltosa (Yeast)
Length = 251
Score = 36.7 bits (81), Expect = 0.32
Identities = 41/152 (26%), Positives = 65/152 (42%), Gaps = 13/152 (8%)
Frame = +2
Query: 41 VDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKGYRSLNLALRKEFDLYANVR 220
+D T V PD + + D+V +G GP L +RKE +LYAN+R
Sbjct: 54 IDATGVPLPDDALESAKNS-DAVLLGAVG--GPKWGTGALRPEQGLLKIRKELNLYANIR 110
Query: 221 PCK----SLEGIKTLYDNV----DVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEAS- 373
PC SL + L V +++ +RE G Y G E + + TE+ +
Sbjct: 111 PCNFASDSLLELSPLRPEVVKGTNLIIVRELVGGIYFGDREEQEESEDKQTAWDTEKYTV 170
Query: 374 ---TRVAEF-AFQFARENKRKKVTAVHKANIM 457
TR+ AF + N + ++ KAN++
Sbjct: 171 DEVTRITRMAAFMALQHNPPLPIWSLDKANVL 202
>UniRef50_A1WV93 Cluster: 3-isopropylmalate dehydrogenase; n=7;
Gammaproteobacteria|Rep: 3-isopropylmalate dehydrogenase
- Halorhodospira halophila (strain DSM 244 / SL1)
(Ectothiorhodospirahalophila (strain DSM 244 / SL1))
Length = 389
Score = 36.3 bits (80), Expect = 0.43
Identities = 28/92 (30%), Positives = 42/92 (45%), Gaps = 9/92 (9%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGIKT-LYD----NVDVVTIRENTEGEYSGIEHEIVDG--- 334
L LRK DL+A RP L G L D + D++ IREN+EGEY + G
Sbjct: 101 LQLRKGLDLWACERPAVPLAGAPMPLSDPRALHTDLLVIRENSEGEYVDQGGRLAAGTPR 160
Query: 335 -VVQSIKLITEEASTRVAEFAFQFARENKRKK 427
+++ T + R+ AF+ A ++
Sbjct: 161 ETATQLEVFTRAGTERIIRHAFERAARRAEER 192
>UniRef50_A2E7S3 Cluster: Putative uncharacterized protein; n=1;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 1175
Score = 36.3 bits (80), Expect = 0.43
Identities = 20/75 (26%), Positives = 40/75 (53%), Gaps = 3/75 (4%)
Frame = +2
Query: 116 NKIGLKGPLMTPVGKGYRSLNLALRKEFDL---YANVRPCKSLEGIKTLYDNVDVVTIRE 286
NK+ L G + V KG+ + L++ K+ + Y +V + L + T N+ +++ +
Sbjct: 533 NKLNLNGSALIAVVKGFLNGELSMWKKISMDTNYMHVSDLQLLTALFTRMPNLRELSLSD 592
Query: 287 NTEGEYSGIEHEIVD 331
N + +GIE+E+ D
Sbjct: 593 NFDASMAGIEYELPD 607
>UniRef50_Q6L0K7 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Thermoplasmatales|Rep: 3-isopropylmalate dehydrogenase -
Picrophilus torridus
Length = 335
Score = 36.3 bits (80), Expect = 0.43
Identities = 17/45 (37%), Positives = 27/45 (60%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGI 313
L LR+E +LY N+RP +S + D + + +RENT+ Y+ I
Sbjct: 84 LRLRRELELYMNIRPVRSFD------DKIKITILRENTQDFYTDI 122
>UniRef50_O59395 Cluster: Putative uncharacterized protein PH1723;
n=1; Pyrococcus horikoshii|Rep: Putative uncharacterized
protein PH1723 - Pyrococcus horikoshii
Length = 122
Score = 36.3 bits (80), Expect = 0.43
Identities = 31/78 (39%), Positives = 40/78 (51%)
Frame = -3
Query: 420 LLFSLANWKANSATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLI 241
+L S A++ AN A L VI L T + + S P YSPS+FSL + S L+ I
Sbjct: 1 MLLSFASFTANLAILSAPFLVIILKSTTLLLSYAPS-PLYSPSLFSLTIIISFLNLKFGI 59
Query: 240 PSKLLQGLTLAYKSNSFL 187
L AYKS+SFL
Sbjct: 60 I------LRFAYKSSSFL 71
>UniRef50_A6GJ83 Cluster: Isocitrate dehydrogenase; n=1;
Plesiocystis pacifica SIR-1|Rep: Isocitrate
dehydrogenase - Plesiocystis pacifica SIR-1
Length = 344
Score = 35.9 bits (79), Expect = 0.56
Identities = 29/108 (26%), Positives = 44/108 (40%), Gaps = 1/108 (0%)
Frame = +2
Query: 140 LMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLY-DNVDVVTIRENTEGEYSGIE 316
L P S N LR+ + RP ++ GI+T Y + + + +R T G Y
Sbjct: 72 LKYPTATTKESPNRVLRERCNFAVIHRPVATIPGIQTHYNERIHLDIVRIATGGTYEDAG 131
Query: 317 HEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIMR 460
I SI+ I S + FAF+ A + + V A K I +
Sbjct: 132 RRINRDTAVSIRAIERRPSVLASRFAFRLA-QLRDSNVIATSKYTIQK 178
>UniRef50_Q7UIE1 Cluster: 3-isopropylmalate dehydrogenase; n=4;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodopirellula baltica
Length = 359
Score = 35.9 bits (79), Expect = 0.56
Identities = 31/104 (29%), Positives = 47/104 (45%), Gaps = 11/104 (10%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGI-------KTLYDNVDVVTIRENTEGEYSGIEHEIVDG- 334
L +RKE L+AN+RP K + + + D++ RE T G Y G G
Sbjct: 93 LKIRKELGLFANLRPIKLFDELADASPLRADIVKGTDILFFRELTGGIYFGESGTSGSGE 152
Query: 335 ---VVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
QS+ E R+ A Q AR + ++T+V KAN++
Sbjct: 153 EETAFQSMTYSVGEVK-RIVRMAAQAAR-GRSNRLTSVDKANVL 194
>UniRef50_Q6AGK4 Cluster: Putative uncharacterized protein; n=1;
Leifsonia xyli subsp. xyli|Rep: Putative uncharacterized
protein - Leifsonia xyli subsp. xyli
Length = 257
Score = 35.1 bits (77), Expect = 0.98
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 4/123 (3%)
Frame = -3
Query: 390 NSATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYS--VLIPSKLLQGL 217
NSA V A++ + ++ P ++ + P SP+ L++ STL+ S +++ L L
Sbjct: 48 NSARTVAAAAAMGVLVSGFPLLLTVTSPHASPTALGLLLLVSTLTRSPLIVVAMALQSYL 107
Query: 216 TLAYKSNSFLRAKLSDL--*PLPTGVIRGPFKPILLAFTESIAFWGIPNLPSGPLTAVTS 43
+ ++ + R LS L L G + G +L S+ F G P P+ + + +
Sbjct: 108 IVFFRQSPNPRRALSALLGLALAAGGVLGVLGLLLGEAVFSLLFPGQPVPPAWLIAVLVA 167
Query: 42 TSS 34
TS+
Sbjct: 168 TSA 170
>UniRef50_A0ZF75 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Nostocaceae|Rep: 3-isopropylmalate dehydrogenase -
Nodularia spumigena CCY 9414
Length = 422
Score = 35.1 bits (77), Expect = 0.98
Identities = 28/103 (27%), Positives = 45/103 (43%), Gaps = 10/103 (9%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGI-------KTLYDNVDVVTIRENTEGEYSGIEHEIVD-- 331
L LRK +D + N+RP + ++ + +D++ IRE G Y G D
Sbjct: 145 LELRKHYDFFCNLRPIRIVDSLVNKSSLRPEKIKGLDILVIRELVSGIYFGSAGRASDEK 204
Query: 332 -GVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
L + R+A A Q A++ +R K+T HK N +
Sbjct: 205 GAYGYHTMLYYDHEIRRLARQALQKAQQ-RRGKLTVAHKENAL 246
>UniRef50_P34738 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Sordariomycetes|Rep: 3-isopropylmalate dehydrogenase -
Neurospora crassa
Length = 368
Score = 35.1 bits (77), Expect = 0.98
Identities = 33/103 (32%), Positives = 45/103 (43%), Gaps = 10/103 (9%)
Frame = +2
Query: 179 LALRKEFDLYANVRPC----KSLEGIKTLYDNV----DVVTIRENTEGEYSGIEHE-IVD 331
L LRKE Y N+RPC +SL L V D + +RE T G Y G E
Sbjct: 95 LKLRKELGTYGNLRPCNFASESLVDSSPLKAEVCRGTDFIVVRELTGGIYFGDRTEDDGS 154
Query: 332 GVVQSIKLITEEASTRVAEFA-FQFARENKRKKVTAVHKANIM 457
G + + R+A A F +N KV ++ KAN++
Sbjct: 155 GYACDTEPYSRAEIVRIARLAGFLALAKNPPAKVWSLDKANVL 197
>UniRef50_Q9FBZ4 Cluster: Putative secreted peptidase; n=1;
Streptomyces coelicolor|Rep: Putative secreted peptidase
- Streptomyces coelicolor
Length = 1239
Score = 34.7 bits (76), Expect = 1.3
Identities = 21/52 (40%), Positives = 24/52 (46%)
Frame = -2
Query: 502 RARDNSAGRGRLTSXHNISFVYSRDLLPLVFSGELEGELRHSRTGLLRDQLD 347
R D R RLT FVY LP V G L+ EL + TGL+ D D
Sbjct: 81 RDADGKPARARLTEADGDLFVYPESALPFVAKGSLDREL-FNVTGLIGDGYD 131
>UniRef50_A5FB87 Cluster: Von Willebrand factor, type A precursor;
n=1; Flavobacterium johnsoniae UW101|Rep: Von Willebrand
factor, type A precursor - Flavobacterium johnsoniae
UW101
Length = 2588
Score = 34.3 bits (75), Expect = 1.7
Identities = 18/60 (30%), Positives = 29/60 (48%)
Frame = -3
Query: 405 ANWKANSATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLIPSKLL 226
AN A + TL AS V +CT +T+ + PEY+ + I+ T + +P L+
Sbjct: 1646 ANLPAGTYTLTAASPVSETQNCTASTTVVITQPEYTVKISGHIINVDTHTGIANVPVTLI 1705
>UniRef50_A3DDD4 Cluster: Phage integrase; n=5; Clostridia|Rep:
Phage integrase - Clostridium thermocellum (strain ATCC
27405 / DSM 1237)
Length = 330
Score = 34.3 bits (75), Expect = 1.7
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Frame = +2
Query: 107 VNANKIGLKGPLMTPVGKGYRS----LNLALRKEFDLYANVRPCKSLEGIKTLY 256
VN N +K ++T VGKG + LN A +K D Y VRP ++ L+
Sbjct: 177 VNINLSNIKNDVLTVVGKGNKERTIYLNAACKKALDAYLKVRPVDGVKDKNALF 230
>UniRef50_A5DW24 Cluster: Putative uncharacterized protein; n=2;
Saccharomycetales|Rep: Putative uncharacterized protein -
Lodderomyces elongisporus (Yeast) (Saccharomyces
elongisporus)
Length = 1274
Score = 34.3 bits (75), Expect = 1.7
Identities = 19/60 (31%), Positives = 35/60 (58%), Gaps = 1/60 (1%)
Frame = -2
Query: 229 LARSDISVQVKLLPEGQVE*SIA-FTDWSHQGTLQANFIGIYRVNRFLGNTEFAIWTPNS 53
+ R ++ VQ+KLL + + E S+A +T+W + Q ++I +++F GN WT +S
Sbjct: 1189 IKRHELLVQLKLLNKMEKEISMAEYTNWLYAEVQQCDYIQESILSQFSGNNPRGDWTESS 1248
>UniRef50_A2TU03 Cluster: Ribonuclease HII; n=1; Dokdonia
donghaensis MED134|Rep: Ribonuclease HII - Dokdonia
donghaensis MED134
Length = 818
Score = 33.9 bits (74), Expect = 2.3
Identities = 22/64 (34%), Positives = 35/64 (54%), Gaps = 4/64 (6%)
Frame = -3
Query: 378 LVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLS--YSVLIPSKLLQ--GLTL 211
L L++ V+ L CTT + S S+ +Y P S++V T+ L S L+ + +Q G T
Sbjct: 5 LYLSAVVVLLASCTTSTKNSSSLTKYIPRKASVVVKTTDLKDFKSALVNNDFIQELGTTS 64
Query: 210 AYKS 199
YK+
Sbjct: 65 LYKT 68
>UniRef50_A7SWW3 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 441
Score = 33.9 bits (74), Expect = 2.3
Identities = 24/65 (36%), Positives = 35/65 (53%)
Frame = -3
Query: 387 SATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLIPSKLLQGLTLA 208
+A ++L SSVI + P++ SIP + + IVT +TL Y L+P L+ LT A
Sbjct: 307 AALIILFSSVIYYSESVDPNSNFTSIPA---TFWYTIVTMTTLGYGDLVPESLVGRLTGA 363
Query: 207 YKSNS 193
S S
Sbjct: 364 LCSLS 368
>UniRef50_Q2UNH1 Cluster: Predicted protein; n=2;
Trichocomaceae|Rep: Predicted protein - Aspergillus
oryzae
Length = 238
Score = 33.9 bits (74), Expect = 2.3
Identities = 32/145 (22%), Positives = 63/145 (43%), Gaps = 8/145 (5%)
Frame = +2
Query: 23 PIEWEEVDVTAVRGPDGKFGIPQKAID--SVNANKIGLKGPLMTPVGKGYRSLNL-ALRK 193
P+E VD++ V GP G P+ +D S + P ++P + S NL A R
Sbjct: 94 PVEVSSVDISPVEGPSSP-GAPEMTMDPSSPGGFSVSPVFPPLSPAVESNGSRNLDAERT 152
Query: 194 EFDLYANVRPCKSLEGIKT-LYDNVDV----VTIRENTEGEYSGIEHEIVDGVVQSIKLI 358
FD+ + P S +++ L D D+ + + +N+ +G +H I + +
Sbjct: 153 SFDVGSADTPTWSDASLRSYLDDESDIRDLFIIVHDNSNVPPAGPDHPITGSLFKEESKR 212
Query: 359 TEEASTRVAEFAFQFARENKRKKVT 433
+E ++++ + RK ++
Sbjct: 213 LKEMNSQLDSMLADWVGRKMRKSIS 237
>UniRef50_Q9RA19 Cluster: ORF10; n=1; Moritella marina|Rep: ORF10 -
Vibrio marinus (Moritella marina)
Length = 2011
Score = 33.5 bits (73), Expect = 3.0
Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Frame = +2
Query: 251 LYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEE--ASTRVAE 388
+YD D+V E G+ G E+ I+DG + ++L T + TRV E
Sbjct: 1156 IYDQADLVEFAEGDIGKVFGAEYNIIDGYSRRVRLPTSDYLLVTRVTE 1203
>UniRef50_Q1QFN8 Cluster: Glycosidase, PH1107-related; n=2;
Bradyrhizobiaceae|Rep: Glycosidase, PH1107-related -
Nitrobacter hamburgensis (strain X14 / DSM 10229)
Length = 373
Score = 33.5 bits (73), Expect = 3.0
Identities = 21/63 (33%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Frame = +2
Query: 23 PIEWEEV-DVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGK--GYRSLNLALRK 193
P+E E V + A RGPDG+ + + + N ++IG+ L +G G L +AL
Sbjct: 20 PLEAEGVLNPAAARGPDGQLYLFPRLVARGNHSRIGIARVLFNEIGDPVGVERLGIALEP 79
Query: 194 EFD 202
E D
Sbjct: 80 EMD 82
>UniRef50_Q8WWQ4 Cluster: Mucin 5; n=5; Catarrhini|Rep: Mucin 5 - Homo
sapiens (Human)
Length = 1349
Score = 33.5 bits (73), Expect = 3.0
Identities = 33/136 (24%), Positives = 55/136 (40%), Gaps = 1/136 (0%)
Frame = -3
Query: 411 SLANW-KANSATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLIPS 235
S ++W K+ + TLV S+ + TT + + +IP +PS S T++T + + S
Sbjct: 1056 STSSWQKSRTTTLVTTSTTSTPQTSTTSAPTTSTIPASTPSTTSAPTTSTTSAPTTSTTS 1115
Query: 234 KLLQGLTLAYKSNSFLRAKLSDL*PLPTGVIRGPFKPILLAFTESIAFWGIPNLPSGPLT 55
T +++ L S T P + A T S + S P +
Sbjct: 1116 APTHRTTSGPTTSTTLAPTTSTTSAPTTSTNSAPTTSTISASTTSTISAPTTSTISSPTS 1175
Query: 54 AVTSTSSHSIGTLAAS 7
+ TST S + A S
Sbjct: 1176 STTSTPQTSKTSAATS 1191
>UniRef50_Q8D4B1 Cluster: Putative uncharacterized protein; n=2;
Vibrio vulnificus|Rep: Putative uncharacterized protein
- Vibrio vulnificus
Length = 1222
Score = 33.1 bits (72), Expect = 4.0
Identities = 15/58 (25%), Positives = 35/58 (60%)
Frame = +2
Query: 257 DNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEFAFQFARENKRKKV 430
D + VT+ + T+GE + + ++ VV K+ ++A+T V ++A++ E +R+++
Sbjct: 527 DTIQYVTVTQGTDGELASVTTQLDQFVVNGFKI--DDATTHVKDYAYR-GVEKRREQI 581
>UniRef50_O59930 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Dikarya|Rep: 3-isopropylmalate dehydrogenase -
Phanerochaete chrysosporium (White-rot fungus)
(Sporotrichumpruinosum)
Length = 380
Score = 33.1 bits (72), Expect = 4.0
Identities = 28/105 (26%), Positives = 41/105 (39%), Gaps = 12/105 (11%)
Frame = +2
Query: 179 LALRKEFDLYANVRPCKSLEGIKTLYD--------NVDVVTIRENTEGEYSGIEHEI--- 325
LALRK LYAN+RP Y VD++ IRE G Y G E+
Sbjct: 96 LALRKALGLYANIRPANFASDSLLAYSPLKPSVARGVDIIVIRELIGGAYFGERKELGAR 155
Query: 326 -VDGVVQSIKLITEEASTRVAEFAFQFARENKRKKVTAVHKANIM 457
+ + + R+ Q A + V ++ KAN++
Sbjct: 156 AQEDAAWDTMIYSVPEVQRITRSRRQVASPDPPLPVHSIDKANVL 200
>UniRef50_Q8VAX3 Cluster: Wsv250; n=2; Shrimp white spot syndrome
virus|Rep: Wsv250 - White spot syndrome virus (WSSV)
Length = 186
Score = 32.3 bits (70), Expect = 6.9
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 3/91 (3%)
Frame = -3
Query: 498 LATTAQEEAV*HXRIILALCTAVTFFLLFSLANWKANSATLVLASS---VISLMDCTTPS 328
+A TA A R+ILA +++ F L+ + A ++A L+LASS SLM T S
Sbjct: 19 MAATAMSTA----RLILASSSSLLFSLMAATA---MSTARLILASSSSLFFSLMAATAMS 71
Query: 327 TISCSIPEYSPSVFSLIVTTSTLSYSVLIPS 235
T + S +FSL+ T+ + +++ S
Sbjct: 72 TARLILASSSSLLFSLMAATAMSTARLILAS 102
Score = 31.9 bits (69), Expect = 9.2
Identities = 25/78 (32%), Positives = 42/78 (53%), Gaps = 3/78 (3%)
Frame = -3
Query: 459 RIILALCTAVTFFLLFSLANWKANSATLVLASS---VISLMDCTTPSTISCSIPEYSPSV 289
R+ILA +++ F L+ + A ++A L+LASS + SLM T ST + S
Sbjct: 5 RLILASSSSLLFSLMAATA---MSTARLILASSSSLLFSLMAATAMSTARLILASSSSLF 61
Query: 288 FSLIVTTSTLSYSVLIPS 235
FSL+ T+ + +++ S
Sbjct: 62 FSLMAATAMSTARLILAS 79
Score = 31.9 bits (69), Expect = 9.2
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 3/91 (3%)
Frame = -3
Query: 498 LATTAQEEAV*HXRIILALCTAVTFFLLFSLANWKANSATLVLASS---VISLMDCTTPS 328
+A TA A R+ILA +++ F L+ + A ++A L+LASS + SLM T S
Sbjct: 42 MAATAMSTA----RLILASSSSLFFSLMAATA---MSTARLILASSSSLLFSLMAATAMS 94
Query: 327 TISCSIPEYSPSVFSLIVTTSTLSYSVLIPS 235
T + S FSL+ T+ + +++ S
Sbjct: 95 TARLILASSSSLFFSLMAATAMSTARLILAS 125
>UniRef50_UPI000023EC3A Cluster: hypothetical protein FG02409.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG02409.1 - Gibberella zeae PH-1
Length = 931
Score = 31.9 bits (69), Expect = 9.2
Identities = 13/27 (48%), Positives = 18/27 (66%)
Frame = -2
Query: 379 SRTGLLRDQLDGLHDPVDDLVLDTGIL 299
+ TGL + Q+D LH V D LDTG++
Sbjct: 613 TETGLFKSQVDFLHRTVRDFFLDTGVI 639
>UniRef50_Q4RK60 Cluster: Chromosome 2 SCAF15032, whole genome shotgun
sequence; n=7; Eumetazoa|Rep: Chromosome 2 SCAF15032,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 4421
Score = 31.9 bits (69), Expect = 9.2
Identities = 14/45 (31%), Positives = 23/45 (51%)
Frame = +2
Query: 29 EWEEVDVTAVRGPDGKFGIPQKAIDSVNANKIGLKGPLMTPVGKG 163
E+ ++ + + G +GK G+ D N + G GP+ TP KG
Sbjct: 3543 EYGDIGLDGINGEEGKGGVSGPPGDRGNPGRRGAPGPIGTPGNKG 3587
>UniRef50_Q92W49 Cluster: Putative chemotaxis methyltransferase
protein; n=2; Sinorhizobium|Rep: Putative chemotaxis
methyltransferase protein - Rhizobium meliloti
(Sinorhizobium meliloti)
Length = 1161
Score = 31.9 bits (69), Expect = 9.2
Identities = 21/83 (25%), Positives = 34/83 (40%)
Frame = +2
Query: 140 LMTPVGKGYRSLNLALRKEFDLYANVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEH 319
L P+ +RSL EF + G+K + + +V +++ E EY+ +
Sbjct: 104 LRAPIDLFFRSLAEEHGSEFAVILTGAGADGAIGVKAVKEAGGIVLVQDPEEAEYASMPR 163
Query: 320 EIVDGVVQSIKLITEEASTRVAE 388
+D V L E RVAE
Sbjct: 164 NAIDTEVADFVLPIRELPHRVAE 186
>UniRef50_Q8R6G0 Cluster: Glycosyl transferase; n=1; Fusobacterium
nucleatum subsp. nucleatum|Rep: Glycosyl transferase -
Fusobacterium nucleatum subsp. nucleatum
Length = 268
Score = 31.9 bits (69), Expect = 9.2
Identities = 19/72 (26%), Positives = 40/72 (55%), Gaps = 1/72 (1%)
Frame = +2
Query: 227 KSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEIVDGVVQSI-KLITEEASTRVAEFAFQF 403
K LE +KT +DNV +++++EN +G+ + +++ + ++ +++ ST+ F Q
Sbjct: 49 KVLEKVKTKHDNVKIISLKEN-KGQSEALNQGLLNCSYDLVARMDSDDISTK-KRFELQI 106
Query: 404 ARENKRKKVTAV 439
NK + AV
Sbjct: 107 DAFNKDYSIDAV 118
>UniRef50_Q2S2N6 Cluster: Possible
2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; n=1;
Salinibacter ruber DSM 13855|Rep: Possible
2-hydroxyhepta-2,4-diene-1,7-dioate isomerase -
Salinibacter ruber (strain DSM 13855)
Length = 220
Score = 31.9 bits (69), Expect = 9.2
Identities = 28/98 (28%), Positives = 46/98 (46%), Gaps = 2/98 (2%)
Frame = +2
Query: 38 EVDVTAVRGPDGKFGIPQK-AIDSVNANKIGLKGPLMTPVGKG-YRSLNLALRKEFDLYA 211
EV++ AV G +GK IP+ A+D V +GL + R ++ K FD +A
Sbjct: 68 EVELVAVVGTEGK-NIPRSAALDHVAGYAVGLDMTARDLQAEAKERRHPWSVAKGFDTFA 126
Query: 212 NVRPCKSLEGIKTLYDNVDVVTIRENTEGEYSGIEHEI 325
+ P + E + + D +T+ + T E S H+I
Sbjct: 127 PLGPIQPAEAVDDVQDLTLRLTVNDETRQEAS-TRHQI 163
>UniRef50_Q1IN93 Cluster: Mg/Co/Ni transporter MgtE; n=1;
Acidobacteria bacterium Ellin345|Rep: Mg/Co/Ni
transporter MgtE - Acidobacteria bacterium (strain
Ellin345)
Length = 412
Score = 31.9 bits (69), Expect = 9.2
Identities = 25/70 (35%), Positives = 33/70 (47%)
Frame = -3
Query: 384 ATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLIPSKLLQGLTLAY 205
A LVLA+S L D + S ISC V L + L+ V+ S +L G+ A
Sbjct: 343 ARLVLANSAAPLSDLSEGSHISCHPDADEREVAELFDKYNLLTLPVVDDSGVLTGVITAD 402
Query: 204 KSNSFLRAKL 175
S LR+KL
Sbjct: 403 DVISLLRSKL 412
>UniRef50_A6PEV1 Cluster: Binding-protein-dependent transport
systems inner membrane component; n=1; Shewanella
sediminis HAW-EB3|Rep: Binding-protein-dependent
transport systems inner membrane component - Shewanella
sediminis HAW-EB3
Length = 317
Score = 31.9 bits (69), Expect = 9.2
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 3/72 (4%)
Frame = -3
Query: 414 FSLANWKANSATLVLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLIP- 238
F AN A+ LA ++ + C T + +SC + S + +L +T ++Y +L+P
Sbjct: 151 FPQANASLLLASFCLALLILPYIACATQNALSCLSKQLSVTGAALGMTQWQVTYRLLLPQ 210
Query: 237 --SKLLQGLTLA 208
S ++ GL LA
Sbjct: 211 ASSGIMSGLMLA 222
>UniRef50_A5GBR8 Cluster: Putative uncharacterized protein precursor;
n=1; Geobacter uraniumreducens Rf4|Rep: Putative
uncharacterized protein precursor - Geobacter
uraniumreducens Rf4
Length = 1439
Score = 31.9 bits (69), Expect = 9.2
Identities = 24/65 (36%), Positives = 34/65 (52%), Gaps = 1/65 (1%)
Frame = -3
Query: 417 LFSLANWKANSATL-VLASSVISLMDCTTPSTISCSIPEYSPSVFSLIVTTSTLSYSVLI 241
L+ A A + +L V AS I+L D T PS S +IP S S+ ++ VT+ T S +
Sbjct: 1153 LYIFAKDAAGNVSLPVTASVTITLSDTTAPSVTSFTIPATSASL-TVAVTSFTASDDTAV 1211
Query: 240 PSKLL 226
LL
Sbjct: 1212 TGYLL 1216
>UniRef50_Q4QHG5 Cluster: Putative uncharacterized protein; n=4;
Leishmania|Rep: Putative uncharacterized protein -
Leishmania major
Length = 6735
Score = 31.9 bits (69), Expect = 9.2
Identities = 25/72 (34%), Positives = 35/72 (48%), Gaps = 2/72 (2%)
Frame = -3
Query: 450 LALCTAVTFFLLFSLANWKA-NSATLVLASSVISL-MDCTTPSTISCSIPEYSPSVFSLI 277
LA A + L SL W A N A VL+S+ I+L P I+ S+ FSL
Sbjct: 5256 LASAAASSPTALLSLCYWSAGNDAVSVLSSNAITLSQGVPPPLDITLSVMAQEVFSFSLS 5315
Query: 276 VTTSTLSYSVLI 241
V+ +T + VL+
Sbjct: 5316 VSPATTDWVVLV 5327
>UniRef50_Q4MYS8 Cluster: Putative uncharacterized protein; n=1;
Theileria parva|Rep: Putative uncharacterized protein -
Theileria parva
Length = 2489
Score = 31.9 bits (69), Expect = 9.2
Identities = 10/45 (22%), Positives = 27/45 (60%)
Frame = +2
Query: 257 DNVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASTRVAEF 391
+NV+++++ E + +Y+G+ H ++D + ++ E R+ +F
Sbjct: 1647 ENVEILSLLERVDLDYTGLVHNVIDNFCEYETVLYENLVDRIGKF 1691
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 475,798,623
Number of Sequences: 1657284
Number of extensions: 9213976
Number of successful extensions: 32516
Number of sequences better than 10.0: 139
Number of HSP's better than 10.0 without gapping: 31160
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 32397
length of database: 575,637,011
effective HSP length: 95
effective length of database: 418,195,031
effective search space used: 32619212418
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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