Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= mg--0657
(693 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P26267 Cluster: Pyruvate dehydrogenase E1 component sub... 126 7e-28
UniRef50_Q9W4H4 Cluster: CG7024-PA; n=2; Sophophora|Rep: CG7024-... 124 3e-27
UniRef50_UPI0000E4A5CB Cluster: PREDICTED: hypothetical protein,... 113 4e-24
UniRef50_Q6NX32 Cluster: Pyruvate dehydrogenase (Lipoamide) alph... 107 3e-22
UniRef50_Q4T3C0 Cluster: Chromosome undetermined SCAF10102, whol... 103 5e-21
UniRef50_P08559 Cluster: Pyruvate dehydrogenase E1 component sub... 102 1e-20
UniRef50_P16387 Cluster: Pyruvate dehydrogenase E1 component sub... 95 2e-18
UniRef50_Q23KL2 Cluster: Pyruvate dehydrogenase E1 component; n=... 93 8e-18
UniRef50_O66112 Cluster: Pyruvate dehydrogenase E1 component sub... 92 1e-17
UniRef50_Q8H1Y0 Cluster: Pyruvate dehydrogenase E1 component sub... 86 7e-16
UniRef50_Q9R9N5 Cluster: Pyruvate dehydrogenase E1 component sub... 86 9e-16
UniRef50_A2QWB4 Cluster: Catalytic activity: Pyruvate + Lipoamid... 85 2e-15
UniRef50_Q1EGI2 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 83 5e-15
UniRef50_Q5FNM5 Cluster: Pyruvate dehydrogenase E1 component alp... 82 1e-14
UniRef50_Q4QDQ1 Cluster: Pyruvate dehydrogenase E1 component alp... 82 1e-14
UniRef50_O96865 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 81 3e-14
UniRef50_Q8SQM8 Cluster: PYRUVATE DEHYDROGENASE E1 COMPONENT ALP... 80 4e-14
UniRef50_Q4WHM5 Cluster: Pyruvate dehydrogenase E1 component alp... 80 4e-14
UniRef50_Q1EGH8 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 79 8e-14
UniRef50_Q2S150 Cluster: Pyruvate dehydrogenase E1 component, al... 79 1e-13
UniRef50_A7CXZ4 Cluster: Pyruvate dehydrogenase; n=1; Opitutacea... 77 4e-13
UniRef50_Q9Z8N4 Cluster: Pyruvate Dehydrogenase Alpha; n=8; Chla... 75 2e-12
UniRef50_Q12FH4 Cluster: Pyruvate dehydrogenase; n=37; Bacteria|... 74 3e-12
UniRef50_Q95VS6 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 72 1e-11
UniRef50_Q42066 Cluster: Pyruvate dehydrogenase E1 componen; n=5... 72 2e-11
UniRef50_A6DTS3 Cluster: Dehydrogenase complex, E1 component, al... 71 2e-11
UniRef50_A6GG24 Cluster: Pyruvate dehydrogenase (Lipoamide), alp... 70 6e-11
UniRef50_P27745 Cluster: Acetoin:2,6-dichlorophenolindophenol ox... 69 1e-10
UniRef50_Q1ATM5 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacte... 69 1e-10
UniRef50_Q74AD3 Cluster: Dehydrogenase complex, E1 component, al... 68 2e-10
UniRef50_Q1KSF1 Cluster: Apicoplast pyruvate dehydrogenase E1 al... 66 6e-10
UniRef50_Q83X26 Cluster: Probable pyruvate dehydrogenase alpha-s... 66 8e-10
UniRef50_Q2ITF8 Cluster: Acetoin dehydrogenase (TPP-dependent) a... 65 1e-09
UniRef50_A5V540 Cluster: Dehydrogenase, E1 component; n=3; Prote... 65 1e-09
UniRef50_Q2WB98 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 65 2e-09
UniRef50_Q6MAE2 Cluster: Putative pyruvate dehydrogenase (Lipoam... 62 1e-08
UniRef50_Q97YF6 Cluster: Pyruvate dehydrogenase, alpha subunit (... 62 1e-08
UniRef50_Q1XDM0 Cluster: Pyruvate dehydrogenase E1 component sub... 62 2e-08
UniRef50_A5UU15 Cluster: Pyruvate dehydrogenase; n=3; Chloroflex... 61 3e-08
UniRef50_A3VIE7 Cluster: Tpp-dependent acetoin dehydrogenase e1 ... 60 7e-08
UniRef50_A6Q3I6 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 59 1e-07
UniRef50_Q7V0M7 Cluster: Dehydrogenase, E1 component; n=1; Proch... 58 2e-07
UniRef50_Q3J9C5 Cluster: Dehydrogenase, E1 component; n=3; Prote... 58 2e-07
UniRef50_A6WG12 Cluster: Pyruvate dehydrogenase; n=3; Actinomyce... 58 2e-07
UniRef50_A0LSF3 Cluster: Pyruvate dehydrogenase; n=5; Bacteria|R... 58 3e-07
UniRef50_Q5VGY4 Cluster: Pyruvate dehydrogenase alpha subunit; n... 58 3e-07
UniRef50_A7HBV0 Cluster: 3-methyl-2-oxobutanoate dehydrogenase; ... 57 4e-07
UniRef50_A4VXG8 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 57 4e-07
UniRef50_A0LTQ9 Cluster: Pyruvate dehydrogenase; n=1; Acidotherm... 56 6e-07
UniRef50_A0JUQ5 Cluster: Pyruvate dehydrogenase; n=4; Actinobact... 56 6e-07
UniRef50_A0UXT3 Cluster: Pyruvate dehydrogenase; n=1; Clostridiu... 56 8e-07
UniRef50_A7BPK6 Cluster: Pyruvate dehydrogenase; n=1; Beggiatoa ... 56 1e-06
UniRef50_Q9HN77 Cluster: Pyruvate dehydrogenase alpha subunit; n... 55 1e-06
UniRef50_Q7N3C2 Cluster: Similar to 3-methyl-2-oxobutanoate dehy... 54 3e-06
UniRef50_Q28MR4 Cluster: Dehydrogenase E1 component; n=8; Bacter... 54 3e-06
UniRef50_Q13GQ3 Cluster: Putative 2-oxo acid dehydrogenase alpha... 54 3e-06
UniRef50_Q53610 Cluster: Branched-chain alpha-keto acid dehydrog... 53 6e-06
UniRef50_Q1NYU1 Cluster: Pyruvate dehydrogenase E1 component alp... 53 6e-06
UniRef50_Q319T4 Cluster: Pyruvate dehydrogenase; n=1; Prochloroc... 53 8e-06
UniRef50_A4AFX0 Cluster: Acetoin dehydrogenase (TPP-dependent) a... 53 8e-06
UniRef50_A4XF89 Cluster: Dehydrogenase, E1 component; n=1; Novos... 52 1e-05
UniRef50_A0HHH5 Cluster: Dehydrogenase, E1 component; n=2; Bacte... 52 1e-05
UniRef50_Q97CK0 Cluster: 2-oxoisovalerate dehydrogenase alpha su... 52 1e-05
UniRef50_Q6A611 Cluster: Pyruvate dehydrogenase E1 component, al... 52 1e-05
UniRef50_Q67SE7 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 52 1e-05
UniRef50_Q1ARM0 Cluster: Pyruvate dehydrogenase; n=3; Bacteria|R... 52 1e-05
UniRef50_Q5SJR9 Cluster: Pyruvate dehydrogenase (Lipoamide) (EC ... 52 2e-05
UniRef50_Q3DZ88 Cluster: Dehydrogenase, E1 component; n=1; Chlor... 52 2e-05
UniRef50_A6UDY5 Cluster: Dehydrogenase E1 component; n=2; Alphap... 52 2e-05
UniRef50_A5V557 Cluster: Pyruvate dehydrogenase; n=1; Sphingomon... 52 2e-05
UniRef50_A3CMZ3 Cluster: Pyruvate dehydrogenase, TPP-dependent E... 51 3e-05
UniRef50_Q83FF2 Cluster: Pyruvate dehydrogenase E1 component alp... 50 4e-05
UniRef50_Q0ET31 Cluster: Dehydrogenase, E1 component; n=1; Therm... 50 4e-05
UniRef50_Q9RYC1 Cluster: 2-oxo acid dehydrogenase, E1 component,... 50 7e-05
UniRef50_Q98FT3 Cluster: Acetoin dehydrogenase (TPP-dependent) a... 50 7e-05
UniRef50_A0LFE6 Cluster: Pyruvate dehydrogenase; n=1; Syntrophob... 50 7e-05
UniRef50_A4X7T3 Cluster: Dehydrogenase, E1 component; n=3; Actin... 49 9e-05
UniRef50_Q748I3 Cluster: Dehydrogenase, E1 component, alpha and ... 49 1e-04
UniRef50_Q1NYL5 Cluster: Pyruvate dehydrogenase E1 component alp... 49 1e-04
UniRef50_Q18CB6 Cluster: Acetoin:2,6-dichlorophenolindophenol ox... 49 1e-04
UniRef50_Q8YDW3 Cluster: 2-OXOISOVALERATE DEHYDROGENASE BETA SUB... 48 2e-04
UniRef50_Q49108 Cluster: Pyruvate dehydrogenase EI alpha subunit... 48 3e-04
UniRef50_Q0RVK8 Cluster: Probable pyruvate dehydrogenase; n=1; R... 47 4e-04
UniRef50_Q0LRY7 Cluster: Dehydrogenase, E1 component:Transketola... 47 4e-04
UniRef50_P37940 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 47 4e-04
UniRef50_Q3DYK5 Cluster: Dehydrogenase, E1 component; n=3; Bacte... 47 5e-04
UniRef50_Q93N50 Cluster: Pyruvate dehydrogenase alpha subunit; n... 46 9e-04
UniRef50_Q00TN9 Cluster: Pyruvate dehydrogenase E1 component bet... 46 9e-04
UniRef50_Q0MX87 Cluster: Acetoin dehydrogenase alpha-subunit; n=... 46 0.001
UniRef50_A4XHV5 Cluster: Transketolase, central region; n=3; Bac... 46 0.001
UniRef50_A1SN84 Cluster: Pyruvate dehydrogenase; n=12; Bacteria|... 45 0.002
UniRef50_Q8U4T5 Cluster: 2-oxo acid dehydrogenase subunit E1; n=... 45 0.002
UniRef50_UPI00005103B4 Cluster: COG1071: Pyruvate/2-oxoglutarate... 44 0.003
UniRef50_A5V4J0 Cluster: Pyruvate dehydrogenase; n=2; Sphingomon... 44 0.003
UniRef50_Q8YDG0 Cluster: 2-OXOISOVALERATE DEHYDROGENASE BETA SUB... 44 0.004
UniRef50_Q0RLC2 Cluster: Pyruvate dehydrogenase E1 component, al... 44 0.004
UniRef50_Q2BFQ9 Cluster: Putative uncharacterized protein; n=1; ... 44 0.005
UniRef50_Q1AZ54 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacte... 44 0.005
UniRef50_A5UVY9 Cluster: Pyruvate dehydrogenase; n=2; Roseiflexu... 44 0.005
UniRef50_Q3WCG3 Cluster: Pyruvate dehydrogenase; n=4; Actinomyce... 43 0.006
UniRef50_Q1IY28 Cluster: Pyruvate dehydrogenase; n=1; Deinococcu... 43 0.006
UniRef50_A5U0N1 Cluster: Dehydrogenase E1 component; n=7; Mycoba... 43 0.006
UniRef50_A3SJ75 Cluster: 2-oxoisovalerate dehydrogenase beta sub... 43 0.008
UniRef50_A1UJ85 Cluster: Pyruvate dehydrogenase; n=16; Mycobacte... 43 0.008
UniRef50_A0K283 Cluster: Pyruvate dehydrogenase; n=4; Actinobact... 42 0.014
UniRef50_Q72GU1 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 41 0.025
UniRef50_Q9KG99 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 41 0.033
UniRef50_Q479Q2 Cluster: Dehydrogenase, E1 component; n=2; Rhodo... 41 0.033
UniRef50_Q02C52 Cluster: Pyruvate dehydrogenase; n=1; Solibacter... 41 0.033
UniRef50_Q020J5 Cluster: Dehydrogenase, E1 component; n=1; Solib... 40 0.044
UniRef50_Q4MTG0 Cluster: Pyruvate dehydrogenase E1 component sub... 40 0.044
UniRef50_Q9K3H0 Cluster: Putative pyruvate dehydrogenase alpha s... 40 0.058
UniRef50_Q3W421 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp... 40 0.058
UniRef50_Q1LFS5 Cluster: Dehydrogenase, E1 component; n=22; Prot... 40 0.058
UniRef50_Q11G20 Cluster: Twin-arginine translocation pathway sig... 40 0.058
UniRef50_Q67ME6 Cluster: Branched-chain alpha-keto acid dehydrog... 40 0.076
UniRef50_A3PXW7 Cluster: Transketolase domain protein; n=4; Myco... 40 0.076
UniRef50_A0LLM4 Cluster: Pyruvate dehydrogenase; n=1; Syntrophob... 40 0.076
UniRef50_A3RZM3 Cluster: Pyruvate dehydrogenase E1 component alp... 39 0.10
UniRef50_Q9LPL5 Cluster: Branched-chain alpha keto-acid dehydrog... 39 0.13
UniRef50_Q4N1L6 Cluster: Branched-chain alpha keto-acid dehydrog... 39 0.13
UniRef50_Q9HNV6 Cluster: Pyruvate dehydrogenase alpha subunit; n... 39 0.13
UniRef50_A7D3P2 Cluster: Pyruvate dehydrogenase; n=1; Halorubrum... 39 0.13
UniRef50_Q8CX87 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 38 0.18
UniRef50_Q5KUY4 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 38 0.18
UniRef50_A7K3C9 Cluster: Dehydrogenase E1 component superfamily;... 38 0.18
UniRef50_P21873 Cluster: Pyruvate dehydrogenase E1 component sub... 38 0.23
UniRef50_Q835M4 Cluster: Pyruvate dehydrogenase complex E1 compo... 36 0.71
UniRef50_A6CP23 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 36 0.71
UniRef50_Q4L1A7 Cluster: Pyruvate dehydrogenase E1 component alp... 36 0.94
UniRef50_P12694 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 36 0.94
UniRef50_Q3E8Q6 Cluster: Uncharacterized protein At5g34780.1; n=... 36 1.2
UniRef50_Q8D6Q7 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 35 1.6
UniRef50_Q83DQ6 Cluster: Dehydrogenase, E1 component, alpha subu... 35 1.6
UniRef50_Q2J998 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp... 35 1.6
UniRef50_Q9P2K3 Cluster: REST corepressor 3; n=25; Tetrapoda|Rep... 35 1.6
UniRef50_Q5LVW0 Cluster: Dehydrogenase/transketolase family prot... 34 2.9
UniRef50_A5NM81 Cluster: Putative uncharacterized protein; n=1; ... 34 2.9
UniRef50_A2C5U8 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 34 2.9
UniRef50_A0H3S4 Cluster: Putative uncharacterized protein; n=1; ... 34 2.9
UniRef50_A4WDQ0 Cluster: Transcriptional regulator, AraC family;... 34 3.8
UniRef50_Q0W151 Cluster: Pyruvate dehydrogenase complex E1, tran... 34 3.8
UniRef50_Q2JA37 Cluster: Pyruvate dehydrogenase; n=11; Actinomyc... 33 5.0
UniRef50_A7RZV6 Cluster: Predicted protein; n=6; Eumetazoa|Rep: ... 33 5.0
UniRef50_Q96JP2 Cluster: Myosin-XVB; n=7; Eutheria|Rep: Myosin-X... 33 5.0
UniRef50_Q5QUK4 Cluster: Alpha keto acid dehydrogenase complex, ... 33 6.6
UniRef50_Q4DB65 Cluster: 2-oxoisovalerate dehydrogenase alpha su... 33 6.6
UniRef50_Q5KGR5 Cluster: Branched-chain alpha-keto acid dehydrog... 33 8.8
UniRef50_Q8ZUR8 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 33 8.8
UniRef50_Q5VST9 Cluster: Obscurin; n=50; Amniota|Rep: Obscurin -... 33 8.8
UniRef50_Q9Y149 Cluster: Mediator of RNA polymerase II transcrip... 33 8.8
>UniRef50_P26267 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha type I, mitochondrial precursor; n=10;
cellular organisms|Rep: Pyruvate dehydrogenase E1
component subunit alpha type I, mitochondrial precursor
- Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Length = 396
Score = 126 bits (303), Expect = 7e-28
Identities = 54/85 (63%), Positives = 66/85 (77%)
Frame = +1
Query: 1 HKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG 180
HKLD GP + +T EDA+ Y Q+ +RR+E+A+GNLYKEK +RGFCHLYSGQEA AVG
Sbjct: 40 HKLDSGPDINVHVTKEDAVHYYTQMLTIRRMESAAGNLYKEKKVRGFCHLYSGQEACAVG 99
Query: 181 MRAAMRDADSVITAYRCHGWTYLMG 255
+AAM D+ +TAYRCHGWTYL G
Sbjct: 100 TKAAMDAGDAAVTAYRCHGWTYLSG 124
Score = 112 bits (270), Expect = 7e-24
Identities = 49/74 (66%), Positives = 58/74 (78%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLA 651
G S+ DLP ++VCENNGYGMGT+ RSSAST+YYTRGDYVPG+WVDGMDVLA
Sbjct: 198 GQLFESMNMAKLWDLPVLYVCENNGYGMGTAAARSSASTDYYTRGDYVPGIWVDGMDVLA 257
Query: 652 TREAARFAIEYCNA 693
R+A R+A E+CNA
Sbjct: 258 VRQAVRWAKEWCNA 271
Score = 91.5 bits (217), Expect = 2e-17
Identities = 43/59 (72%), Positives = 46/59 (77%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVAFAHKYRAD 428
G SV VL ELTGR TG GKGGSMH+YG NFYGGNGIVGAQ PLG G+AFA KYR +
Sbjct: 124 GSSVAKVLCELTGRITGNVYGKGGSMHMYGENFYGGNGIVGAQQPLGTGIAFAMKYRKE 182
Score = 43.6 bits (98), Expect = 0.005
Identities = 18/42 (42%), Positives = 27/42 (64%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
P+G+ + + + V ++GDGA NQGQLFE+ NM+KL
Sbjct: 168 PLGTGIAFAMKYRKEKNVCITMFGDGATNQGQLFESMNMAKL 209
>UniRef50_Q9W4H4 Cluster: CG7024-PA; n=2; Sophophora|Rep: CG7024-PA
- Drosophila melanogaster (Fruit fly)
Length = 479
Score = 124 bits (298), Expect = 3e-27
Identities = 54/86 (62%), Positives = 65/86 (75%)
Frame = +1
Query: 1 HKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG 180
+ L+ GP L+ EDAL +Y Q+ LRR ET +GN YKE+ IRGFCHLY+GQEAVAVG
Sbjct: 46 YDLENGPTMDVELSREDALTMYTQMLELRRFETVAGNYYKERKIRGFCHLYNGQEAVAVG 105
Query: 181 MRAAMRDADSVITAYRCHGWTYLMGL 258
M+ +R DSVITAYRCH WTYLMG+
Sbjct: 106 MKQRLRSCDSVITAYRCHAWTYLMGV 131
Score = 97.5 bits (232), Expect = 3e-19
Identities = 42/59 (71%), Positives = 48/59 (81%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVAFAHKYRAD 428
GVS+ +++EL G RTGCSRGKGGSMH+Y FYGGNGIVGAQVPLGAG+ AH YR D
Sbjct: 130 GVSLYEIMAELFGVRTGCSRGKGGSMHMYSDKFYGGNGIVGAQVPLGAGIGLAHSYRKD 188
Score = 92.3 bits (219), Expect = 1e-17
Identities = 37/57 (64%), Positives = 46/57 (80%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEY 684
LPC+FVCENN YGMGT V R+SA TE+Y RG Y+PG+WVDG VLA R A +FA+++
Sbjct: 218 LPCIFVCENNHYGMGTHVKRASAMTEFYMRGQYIPGLWVDGNQVLAVRSATQFAVDH 274
Score = 54.0 bits (124), Expect = 3e-06
Identities = 26/50 (52%), Positives = 34/50 (68%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKLGTCLASSF 532
P+G+ GL + GV+ LYGDGAANQGQ+FE++NM+KL CL F
Sbjct: 174 PLGAGIGLAHSYRKDNGVSVVLYGDGAANQGQIFESFNMAKL-WCLPCIF 222
>UniRef50_UPI0000E4A5CB Cluster: PREDICTED: hypothetical protein,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: hypothetical protein, partial -
Strongylocentrotus purpuratus
Length = 378
Score = 113 bits (272), Expect = 4e-24
Identities = 48/90 (53%), Positives = 65/90 (72%)
Frame = +1
Query: 1 HKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG 180
HKL++GP ++ LT ++AL Y ++ +RR+ETA+ LYK K +RGFCHLYSGQEA AVG
Sbjct: 169 HKLEEGPKKTSVLTKDEALDYYHKMQTIRRMETAAATLYKSKEVRGFCHLYSGQEACAVG 228
Query: 181 MRAAMRDADSVITAYRCHGWTYLMGLVCWG 270
+ + + D+VITAYR HGW YL G+ G
Sbjct: 229 ISSVLTPDDAVITAYRAHGWAYLRGVTLHG 258
Score = 101 bits (242), Expect = 2e-20
Identities = 44/56 (78%), Positives = 52/56 (92%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVAFAHKY 419
GV++ GVL+ELTGRRTGC++GKGGSMH+Y +NFYGGNGIVGAQVPLGAG+A A KY
Sbjct: 253 GVTLHGVLAELTGRRTGCAKGKGGSMHMYCKNFYGGNGIVGAQVPLGAGIALALKY 308
Score = 83.4 bits (197), Expect = 5e-15
Identities = 31/39 (79%), Positives = 38/39 (97%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVW 627
DLPC+FVCENN YGMGT+V+RS+AST+YYTRGDY+PG+W
Sbjct: 340 DLPCIFVCENNKYGMGTAVERSAASTDYYTRGDYIPGIW 378
Score = 50.4 bits (115), Expect = 4e-05
Identities = 22/42 (52%), Positives = 31/42 (73%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
P+G+ L + ++ V +LYGDGAANQGQ+FEAYN++KL
Sbjct: 297 PLGAGIALALKYTDKKNVCISLYGDGAANQGQVFEAYNIAKL 338
>UniRef50_Q6NX32 Cluster: Pyruvate dehydrogenase (Lipoamide) alpha
1; n=3; Tetrapoda|Rep: Pyruvate dehydrogenase
(Lipoamide) alpha 1 - Xenopus tropicalis (Western clawed
frog) (Silurana tropicalis)
Length = 369
Score = 107 bits (256), Expect = 3e-22
Identities = 46/86 (53%), Positives = 60/86 (69%)
Frame = +1
Query: 1 HKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG 180
H+L++GP T A LT E L+ Y + +RR+E S LYK+KIIRGFCHLY GQEA VG
Sbjct: 54 HRLEEGPPTQAVLTREQGLQYYRTMQTIRRMELKSDQLYKQKIIRGFCHLYDGQEACCVG 113
Query: 181 MRAAMRDADSVITAYRCHGWTYLMGL 258
+ AA+ D +ITAYR HG++Y G+
Sbjct: 114 LEAAINPTDHLITAYRAHGYSYTRGV 139
Score = 101 bits (241), Expect = 2e-20
Identities = 40/60 (66%), Positives = 52/60 (86%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEYCNA 693
LPC+F+CENN YGMGTSV+R++AST+YY RGDY+PG+ VDGMDVL REA +FA ++C +
Sbjct: 195 LPCIFICENNRYGMGTSVERAAASTDYYKRGDYIPGLRVDGMDVLCVREATQFAADHCRS 254
Score = 79.0 bits (186), Expect = 1e-13
Identities = 33/45 (73%), Positives = 40/45 (88%)
Frame = +3
Query: 246 SHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQ 380
+ GVSV +L+ELTGRR GC++GKGGSMH+Y +NFYGGNGIVGAQ
Sbjct: 136 TRGVSVKEILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQ 180
>UniRef50_Q4T3C0 Cluster: Chromosome undetermined SCAF10102, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF10102,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 491
Score = 103 bits (246), Expect = 5e-21
Identities = 66/168 (39%), Positives = 85/168 (50%), Gaps = 23/168 (13%)
Frame = +1
Query: 1 HKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG 180
H+L++GP A LT E L+ Y + +RR+E + LYK+KIIRGFCHLY GQEA A G
Sbjct: 6 HRLEEGPPEKAELTREQGLQYYRTMQTIRRMELKADQLYKQKIIRGFCHLYDGQEACAAG 65
Query: 181 MRAAMRDADSVITAYRCHGWTYLMGL----VCWGCSRS*RGAGP---------------V 303
+ AA+ +D +ITAYR HG+T+ G+ + + G P V
Sbjct: 66 IEAAITPSDHLITAYRAHGYTFTRGVSVKEILAELTGETGGTFPSSLVPQRLHRSLPPQV 125
Query: 304 APG----AREVPCICTDATSMVATGLLVRRSRWELEWPSPTSTAPTGS 435
A G A+ C CT S AT R WELE P ST T S
Sbjct: 126 AEGAWPKAKGALCTCTRLISTEATASWELRFLWELELLWPASTRETSS 173
>UniRef50_P08559 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha, somatic form, mitochondrial precursor;
n=110; cellular organisms|Rep: Pyruvate dehydrogenase E1
component subunit alpha, somatic form, mitochondrial
precursor - Homo sapiens (Human)
Length = 390
Score = 102 bits (244), Expect = 1e-20
Identities = 44/86 (51%), Positives = 58/86 (67%)
Frame = +1
Query: 1 HKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG 180
H+L++GP + LT ED LK Y + +RR+E + LYK+KIIRGFCHL GQEA VG
Sbjct: 44 HRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVG 103
Query: 181 MRAAMRDADSVITAYRCHGWTYLMGL 258
+ A + D +ITAYR HG+T+ GL
Sbjct: 104 LEAGINPTDHLITAYRAHGFTFTRGL 129
Score = 101 bits (242), Expect = 2e-20
Identities = 40/60 (66%), Positives = 51/60 (85%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEYCNA 693
LPC+F+CENN YGMGTSV+R++AST+YY RGD++PG+ VDGMD+L REA RFA YC +
Sbjct: 216 LPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRS 275
Score = 98.3 bits (234), Expect = 2e-19
Identities = 42/63 (66%), Positives = 52/63 (82%)
Frame = +3
Query: 246 SHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVAFAHKYRA 425
+ G+SV +L+ELTGR+ GC++GKGGSMH+Y +NFYGGNGIVGAQVPLGAG+A A KY
Sbjct: 126 TRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNG 185
Query: 426 DGE 434
E
Sbjct: 186 KDE 188
Score = 46.8 bits (106), Expect = 5e-04
Identities = 22/42 (52%), Positives = 28/42 (66%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
P+G+ L + + V LYGDGAANQGQ+FEAYNM+ L
Sbjct: 172 PLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAAL 213
>UniRef50_P16387 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha, mitochondrial precursor; n=34;
Dikarya|Rep: Pyruvate dehydrogenase E1 component subunit
alpha, mitochondrial precursor - Saccharomyces
cerevisiae (Baker's yeast)
Length = 420
Score = 94.7 bits (225), Expect = 2e-18
Identities = 43/57 (75%), Positives = 47/57 (82%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVAFAHKYR 422
G SV VL+EL GRR G S GKGGSMHLY FYGGNGIVGAQVPLGAG+AFAH+Y+
Sbjct: 148 GASVKAVLAELMGRRAGVSYGKGGSMHLYAPGFYGGNGIVGAQVPLGAGLAFAHQYK 204
Score = 87.4 bits (207), Expect = 3e-16
Identities = 39/79 (49%), Positives = 54/79 (68%)
Frame = +1
Query: 19 PATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMR 198
P S + L++Y+ + I+RR+E A LYK K IRGFCHL GQEA+AVG+ A+
Sbjct: 70 PDLSYETSKATLLQMYKDMVIIRRMEMACDALYKAKKIRGFCHLSVGQEAIAVGIENAIT 129
Query: 199 DADSVITAYRCHGWTYLMG 255
DS+IT+YRCHG+T++ G
Sbjct: 130 KLDSIITSYRCHGFTFMRG 148
Score = 85.0 bits (201), Expect = 2e-15
Identities = 35/59 (59%), Positives = 47/59 (79%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEYC 687
+LP VF CENN YGMGT+ RSSA TEY+ RG Y+PG+ V+GMD+LA +A++FA ++C
Sbjct: 235 NLPVVFCCENNKYGMGTAASRSSAMTEYFKRGQYIPGLKVNGMDILAVYQASKFAKDWC 293
Score = 47.6 bits (108), Expect = 3e-04
Identities = 20/42 (47%), Positives = 28/42 (66%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
P+G+ Q +F LYGDGA+NQGQ+FE++NM+KL
Sbjct: 192 PLGAGLAFAHQYKNEDACSFTLYGDGASNQGQVFESFNMAKL 233
>UniRef50_Q23KL2 Cluster: Pyruvate dehydrogenase E1 component; n=5;
Intramacronucleata|Rep: Pyruvate dehydrogenase E1
component - Tetrahymena thermophila SB210
Length = 429
Score = 92.7 bits (220), Expect = 8e-18
Identities = 41/77 (53%), Positives = 53/77 (68%)
Frame = +1
Query: 25 TSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDA 204
T +T T E+ LKLY+ + ++R+IE A LYK++ IRGFCHLY GQEAV G+ AA
Sbjct: 87 TQSTATKEELLKLYKDMNVMRKIELACDKLYKQREIRGFCHLYDGQEAVISGIEAACNLE 146
Query: 205 DSVITAYRCHGWTYLMG 255
D++ITAYRCH Y G
Sbjct: 147 DAIITAYRCHCHAYTRG 163
Score = 76.2 bits (179), Expect = 7e-13
Identities = 34/52 (65%), Positives = 44/52 (84%), Gaps = 2/52 (3%)
Frame = +3
Query: 270 VLSELTGRRTGCSRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVAFAHKY 419
+++EL GR+TG + GKGGSMH Y + +FYGG+GIVGAQVP+GAG+AFA KY
Sbjct: 169 IIAELMGRKTGSTGGKGGSMHFYRKKTHFYGGHGIVGAQVPMGAGLAFALKY 220
Score = 76.2 bits (179), Expect = 7e-13
Identities = 31/58 (53%), Positives = 44/58 (75%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEY 684
+LPC+FVCENN YGMGTS R+S +T++YTRGD +PG+ +DG + +E +FA +Y
Sbjct: 252 NLPCLFVCENNLYGMGTSTARASHNTDFYTRGDKIPGIRMDGNNYFHVKEGFKFAKQY 309
Score = 40.7 bits (91), Expect = 0.033
Identities = 18/42 (42%), Positives = 27/42 (64%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
P+G+ + ++ V+ +YGDGAANQGQ+ EA NM+ L
Sbjct: 209 PMGAGLAFALKYEKKPNVSITMYGDGAANQGQIAEAANMAGL 250
>UniRef50_O66112 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=38; Proteobacteria|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Zymomonas
mobilis
Length = 354
Score = 91.9 bits (218), Expect = 1e-17
Identities = 42/65 (64%), Positives = 52/65 (80%), Gaps = 2/65 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVAFAHK 416
L++G+ V++ELTGR +G S GKGGSMH++ F+GGNGIVGAQVPLGAG+AFAHK
Sbjct: 104 LAYGIDPKIVMAELTGRASGISHGKGGSMHMFSTEHKFFGGNGIVGAQVPLGAGLAFAHK 163
Query: 417 YRADG 431
YR DG
Sbjct: 164 YRNDG 168
Score = 74.5 bits (175), Expect = 2e-12
Identities = 36/72 (50%), Positives = 48/72 (66%), Gaps = 1/72 (1%)
Frame = +1
Query: 46 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDA-DSVITA 222
E+ L+ Y ++ ++RR E G LY +I GFCHLY GQEAVAVG++AA++ DSVIT
Sbjct: 37 EELLEFYRRMLMIRRFEERCGQLYGLGLIAGFCHLYIGQEAVAVGLQAALQPGRDSVITG 96
Query: 223 YRCHGWTYLMGL 258
YR HG G+
Sbjct: 97 YREHGHMLAYGI 108
Score = 61.7 bits (143), Expect = 2e-08
Identities = 31/62 (50%), Positives = 40/62 (64%), Gaps = 2/62 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGD--YVPGVWVDGMDVLATREAARFAIEYC 687
LP +FV ENNGY MGTS+ R++A T RG +P + VDGMDVL R AA A+++
Sbjct: 197 LPVIFVIENNGYAMGTSIQRANAHTALSERGAGFGIPALVVDGMDVLEVRGAATVAVDWV 256
Query: 688 NA 693
A
Sbjct: 257 QA 258
Score = 41.1 bits (92), Expect = 0.025
Identities = 18/42 (42%), Positives = 27/42 (64%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
P+G+ + G + A +GDG+ANQGQ++EAYNM+ L
Sbjct: 153 PLGAGLAFAHKYRNDGGCSAAYFGDGSANQGQVYEAYNMAAL 194
>UniRef50_Q8H1Y0 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha-2, mitochondrial precursor; n=33; cellular
organisms|Rep: Pyruvate dehydrogenase E1 component
subunit alpha-2, mitochondrial precursor - Arabidopsis
thaliana (Mouse-ear cress)
Length = 393
Score = 86.2 bits (204), Expect = 7e-16
Identities = 38/76 (50%), Positives = 54/76 (71%)
Frame = +1
Query: 7 LDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMR 186
L + P+ S +SE+ L + + +RR+E A+ +LYK K+IRGFCHLY GQEA+AVGM
Sbjct: 48 LCESPSRSVETSSEEILAFFRDMARMRRMEIAADSLYKAKLIRGFCHLYDGQEALAVGME 107
Query: 187 AAMRDADSVITAYRCH 234
AA+ D++IT+YR H
Sbjct: 108 AAITKKDAIITSYRDH 123
Score = 85.8 bits (203), Expect = 9e-16
Identities = 38/64 (59%), Positives = 47/64 (73%), Gaps = 2/64 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVAFAHK 416
+ G ++ SEL GR+TGCS GKGGSMH Y ++ FYGG+GIVGAQ+PLG G+AFA K
Sbjct: 127 IGRGGKLVDAFSELMGRKTGCSHGKGGSMHFYKKDASFYGGHGIVGAQIPLGCGLAFAQK 186
Query: 417 YRAD 428
Y D
Sbjct: 187 YNKD 190
Score = 81.4 bits (192), Expect = 2e-14
Identities = 35/58 (60%), Positives = 44/58 (75%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEY 684
DLP + VCENN YGMGT+ RS+ S Y+ RGDYVPG+ VDGMD LA ++A +FA E+
Sbjct: 219 DLPAILVCENNHYGMGTATWRSAKSPAYFKRGDYVPGLKVDGMDALAVKQACKFAKEH 276
Score = 50.4 bits (115), Expect = 4e-05
Identities = 24/42 (57%), Positives = 28/42 (66%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
P+G + + VTFALYGDGAANQGQLFEA N+S L
Sbjct: 176 PLGCGLAFAQKYNKDEAVTFALYGDGAANQGQLFEALNISAL 217
>UniRef50_Q9R9N5 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=62; Bacteria|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Rhizobium
meliloti (Sinorhizobium meliloti)
Length = 348
Score = 85.8 bits (203), Expect = 9e-16
Identities = 39/64 (60%), Positives = 53/64 (82%), Gaps = 2/64 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVAFAHK 416
L+ G+S GV++ELTGRR G S+GKGGSMH++ ++FYGG+GIVGAQV LG G+AFA++
Sbjct: 100 LACGMSARGVMAELTGRRGGLSKGKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANR 159
Query: 417 YRAD 428
YR +
Sbjct: 160 YRGN 163
Score = 85.0 bits (201), Expect = 2e-15
Identities = 41/89 (46%), Positives = 52/89 (58%)
Frame = +1
Query: 4 KLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGM 183
K D T A + ED LK Y ++ ++RR E +G LY I GFCHLY GQEAV VGM
Sbjct: 20 KKDFAGGTIAEFSKEDDLKAYREMLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVVGM 79
Query: 184 RAAMRDADSVITAYRCHGWTYLMGLVCWG 270
+ A+++ D VIT YR HG G+ G
Sbjct: 80 QLALKEGDQVITGYRDHGHMLACGMSARG 108
Score = 65.7 bits (153), Expect = 1e-09
Identities = 31/62 (50%), Positives = 42/62 (67%), Gaps = 2/62 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAIEYC 687
LP +++ ENN Y MGTSV R+SA T++ RG +PG VDGMDV A + AA A+E+C
Sbjct: 193 LPVIYIVENNRYAMGTSVSRASAQTDFSQRGASFGIPGYQVDGMDVRAVKAAADEAVEHC 252
Query: 688 NA 693
+
Sbjct: 253 RS 254
Score = 39.1 bits (87), Expect = 0.10
Identities = 15/25 (60%), Positives = 22/25 (88%)
Frame = +2
Query: 434 VTFALYGDGAANQGQLFEAYNMSKL 508
V+ A +GDGAANQGQ++E++NM+ L
Sbjct: 166 VSLAYFGDGAANQGQVYESFNMAAL 190
>UniRef50_A2QWB4 Cluster: Catalytic activity: Pyruvate + Lipoamide
<=> S-Acetyldihydrolipoamide + CO2; n=3; Ascomycota|Rep:
Catalytic activity: Pyruvate + Lipoamide <=>
S-Acetyldihydrolipoamide + CO2 - Aspergillus niger
Length = 403
Score = 84.6 bits (200), Expect = 2e-15
Identities = 41/85 (48%), Positives = 56/85 (65%)
Frame = +1
Query: 1 HKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG 180
+ LD P + T T +LY ++++RR+E A+ LYKE+ IRGFCHL +GQEAVAVG
Sbjct: 57 YNLDPPPYSLET-TKSQLKQLYYDMSLIRRMELAADKLYKEQKIRGFCHLSTGQEAVAVG 115
Query: 181 MRAAMRDADSVITAYRCHGWTYLMG 255
+ + D VITAYR HG+T + G
Sbjct: 116 VEHGISPEDKVITAYRAHGFTLMRG 140
Score = 81.0 bits (191), Expect = 3e-14
Identities = 34/59 (57%), Positives = 44/59 (74%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVAFAHKY 419
L G SV ++ EL GRR G GKGGS+H++ +NF+GGNGIVG+ VPLG G+AFA +Y
Sbjct: 137 LMRGGSVKSIIGELLGRRDGICHGKGGSVHMFTKNFFGGNGIVGSNVPLGTGIAFAQQY 195
Score = 80.2 bits (189), Expect = 4e-14
Identities = 34/58 (58%), Positives = 45/58 (77%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEY 684
+LP +F CENN YGMGTSV+R+SA TEYY RG Y+PG+ ++GMDVLA A ++ +Y
Sbjct: 227 ELPVIFGCENNKYGMGTSVERASAMTEYYKRGYYIPGLRINGMDVLAVIAAMKYGKDY 284
Score = 48.8 bits (111), Expect = 1e-04
Identities = 23/42 (54%), Positives = 28/42 (66%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
P+G+ Q + VT LYGDGAANQGQ+ EAYNM+KL
Sbjct: 184 PLGTGIAFAQQYDDTKKVTVNLYGDGAANQGQVHEAYNMAKL 225
>UniRef50_Q1EGI2 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=6; Spirotrichea|Rep: Pyruvate dehydrogenase E1 alpha
subunit - Euplotes sp. BB-2004
Length = 389
Score = 83.4 bits (197), Expect = 5e-15
Identities = 37/79 (46%), Positives = 51/79 (64%), Gaps = 1/79 (1%)
Frame = +1
Query: 1 HKLDQGPA-TSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAV 177
H++++ T AT T + L Y+ + ++RR+E S LYK K IRGFCHLY GQE++ V
Sbjct: 37 HRIEESELPTKATTTKSELLNYYKDMALMRRVEIVSDMLYKNKWIRGFCHLYDGQESITV 96
Query: 178 GMRAAMRDADSVITAYRCH 234
GM AA+ D +I AYR H
Sbjct: 97 GMEAALTMEDHIINAYRDH 115
Score = 75.4 bits (177), Expect = 1e-12
Identities = 36/66 (54%), Positives = 44/66 (66%), Gaps = 2/66 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLY--GRNFYGGNGIVGAQVPLGAGVAFAHK 416
+ G + +++E+ R TG S+GKGGSMH Y NFYGGNGIVGAQVP+G GVAF K
Sbjct: 119 MGRGHTSYEIIAEMMQRSTGSSKGKGGSMHYYCSKNNFYGGNGIVGAQVPVGTGVAFGIK 178
Query: 417 YRADGE 434
Y E
Sbjct: 179 YEGKKE 184
Score = 63.3 bits (147), Expect = 5e-09
Identities = 25/58 (43%), Positives = 37/58 (63%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEYC 687
LP ++ CENN Y MGTS++R + + +Y RGD +PGV +V A RE ++ +YC
Sbjct: 212 LPIIYTCENNKYAMGTSIERHAHNLNFYKRGDLIPGVRCQANNVFAVRELYKWGKKYC 269
Score = 43.2 bits (97), Expect = 0.006
Identities = 20/42 (47%), Positives = 28/42 (66%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
PVG+ + ++ V A+YGDGAANQGQ++EA NM+ L
Sbjct: 168 PVGTGVAFGIKYEGKKEVCVAMYGDGAANQGQIYEAANMAGL 209
>UniRef50_Q5FNM5 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=4; Bacteria|Rep: Pyruvate dehydrogenase E1
component alpha subunit - Gluconobacter oxydans
(Gluconobacter suboxydans)
Length = 334
Score = 82.2 bits (194), Expect = 1e-14
Identities = 39/63 (61%), Positives = 48/63 (76%), Gaps = 2/63 (3%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVAFAHKYRA 425
G++ GV++ELTGR G S GKGGSMH++ R FYGG+GIVGAQV LG G+AFA+KYR
Sbjct: 88 GMTPRGVMAELTGRSGGYSHGKGGSMHMFSREKEFYGGHGIVGAQVALGTGLAFANKYRG 147
Query: 426 DGE 434
E
Sbjct: 148 TDE 150
Score = 70.9 bits (166), Expect = 3e-11
Identities = 33/81 (40%), Positives = 46/81 (56%)
Frame = +1
Query: 16 GPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAM 195
G + L+ E + Y + ++RR E +G LY +I GFCHLY GQEAV VG+ M
Sbjct: 9 GRSNGPALSPETMKRAYRDMLLVRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGIGLNM 68
Query: 196 RDADSVITAYRCHGWTYLMGL 258
+ D IT+YR HG + G+
Sbjct: 69 KQGDKSITSYRDHGQMLVAGM 89
Score = 67.3 bits (157), Expect = 3e-10
Identities = 31/62 (50%), Positives = 43/62 (69%), Gaps = 2/62 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGD--YVPGVWVDGMDVLATREAARFAIEYC 687
LPC++V ENN YGMGTS++R+SAS + G+ + VDGMD+ A EAA+ A+EYC
Sbjct: 178 LPCIYVIENNRYGMGTSIERASASKDLSRNGEPWGIASRKVDGMDIFAVHEAAQEAMEYC 237
Query: 688 NA 693
+
Sbjct: 238 RS 239
>UniRef50_Q4QDQ1 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit, putative; n=5; Euglenozoa|Rep: Pyruvate
dehydrogenase E1 component alpha subunit, putative -
Leishmania major
Length = 378
Score = 82.2 bits (194), Expect = 1e-14
Identities = 36/72 (50%), Positives = 46/72 (63%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLA 651
G S+ + LP +F ENN +GMGTS R S E+Y RGDY+PG+ VDGMDVLA
Sbjct: 193 GQIYESMNIAALQRLPVIFAVENNHFGMGTSAARGSYQAEFYRRGDYIPGIKVDGMDVLA 252
Query: 652 TREAARFAIEYC 687
+E R+A +YC
Sbjct: 253 VQEGTRYARDYC 264
Score = 70.9 bits (166), Expect = 3e-11
Identities = 33/57 (57%), Positives = 42/57 (73%), Gaps = 2/57 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLY--GRNFYGGNGIVGAQVPLGAGVAF 407
+S G V +E+ GR+ GCS+GKGGSMH+Y FYGGNGIVGAQV +GAG+A+
Sbjct: 111 ISRGGKPEDVFAEMFGRQGGCSKGKGGSMHMYRVDNGFYGGNGIVGAQVSIGAGLAW 167
Score = 66.5 bits (155), Expect = 6e-10
Identities = 33/80 (41%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Frame = +1
Query: 4 KLDQGPATSATLTSEDALKLYEQLTI-LRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG 180
+ D P + + + LK L +RR+E+ YK K IRGFCHLY GQEA+ G
Sbjct: 30 RTDMAPLPTQAVYDAEQLKQSLALMFRIRRMESLCDQSYKLKKIRGFCHLYIGQEAIPAG 89
Query: 181 MRAAMRDADSVITAYRCHGW 240
M + D +IT YR HGW
Sbjct: 90 MENVLTFEDPIITGYRDHGW 109
Score = 37.9 bits (84), Expect = 0.23
Identities = 17/30 (56%), Positives = 23/30 (76%)
Frame = +2
Query: 419 PRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
P+ VTF YGDGAANQGQ++E+ N++ L
Sbjct: 177 PKHVAVTF--YGDGAANQGQIYESMNIAAL 204
>UniRef50_O96865 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=2; Trypanosoma cruzi|Rep: Pyruvate dehydrogenase E1
alpha subunit - Trypanosoma cruzi
Length = 378
Score = 80.6 bits (190), Expect = 3e-14
Identities = 33/58 (56%), Positives = 44/58 (75%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEYC 687
+P +F CENN +GMGTS +R++ E Y RGDY+PG+ VDGMDVLA +E R+A E+C
Sbjct: 207 IPVIFCCENNQFGMGTSKERAAYQPEMYRRGDYIPGLQVDGMDVLAVQEGTRWAKEWC 264
Score = 74.1 bits (174), Expect = 3e-12
Identities = 35/77 (45%), Positives = 46/77 (59%)
Frame = +1
Query: 25 TSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDA 204
T+AT +E K E + +RR+E+ YK K IRGFCHLY GQEA+ VGM +
Sbjct: 38 TTATYDTEQMKKCLEMMFRIRRMESLCDQSYKLKKIRGFCHLYIGQEAIPVGMENVLTLE 97
Query: 205 DSVITAYRCHGWTYLMG 255
D ++TAYR H W + G
Sbjct: 98 DLIVTAYRDHAWYIVRG 114
Score = 70.9 bits (166), Expect = 3e-11
Identities = 30/48 (62%), Positives = 39/48 (81%), Gaps = 2/48 (4%)
Frame = +3
Query: 270 VLSELTGRRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVAF 407
V +E+ G+ GCS+GKGGSMH+Y NF+GGNGIVGAQVP+GAG+ +
Sbjct: 120 VFAEMFGKEGGCSKGKGGSMHMYSVKNNFFGGNGIVGAQVPIGAGLGW 167
Score = 41.9 bits (94), Expect = 0.014
Identities = 21/45 (46%), Positives = 28/45 (62%), Gaps = 3/45 (6%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRR---RGVTFALYGDGAANQGQLFEAYNMSKL 508
P+G+ G R + R R V YGDGAANQGQ+FEA N++ +
Sbjct: 160 PIGAGLGWRFALENRDKPRNVAVTFYGDGAANQGQVFEAMNIAAI 204
>UniRef50_Q8SQM8 Cluster: PYRUVATE DEHYDROGENASE E1 COMPONENT ALPHA
SUBUNIT; n=1; Encephalitozoon cuniculi|Rep: PYRUVATE
DEHYDROGENASE E1 COMPONENT ALPHA SUBUNIT -
Encephalitozoon cuniculi
Length = 349
Score = 80.2 bits (189), Expect = 4e-14
Identities = 32/56 (57%), Positives = 46/56 (82%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVAFAHKY 419
G S+L ++ E+ GR+ G +GKGGSMHLY ++F+GG+GIVGAQ+PLG G+A+A +Y
Sbjct: 105 GCSILEIMGEVLGRQAGVCKGKGGSMHLYNKSFFGGHGIVGAQIPLGLGMAYALEY 160
Score = 64.1 bits (149), Expect = 3e-09
Identities = 29/70 (41%), Positives = 43/70 (61%)
Frame = +1
Query: 46 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAY 225
+ A+ +Y+Q+ +R ++ A YK K IRGFCHL GQE + + AM D D +++Y
Sbjct: 37 DKAVYIYKQMMRMRCMDEAMDREYKRKNIRGFCHLSIGQEGIYAALEYAM-DGDVAVSSY 95
Query: 226 RCHGWTYLMG 255
RCHG Y+ G
Sbjct: 96 RCHGIAYVTG 105
Score = 57.6 bits (133), Expect = 3e-07
Identities = 24/57 (42%), Positives = 34/57 (59%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEY 684
LP VFVCENNGYGM T SA T++Y RG +PG+ + ++ ++A +Y
Sbjct: 199 LPIVFVCENNGYGMWTPASSVSADTDFYLRGGAIPGIRIGHGNIFGLMSVLKYARKY 255
Score = 39.5 bits (88), Expect = 0.076
Identities = 15/23 (65%), Positives = 21/23 (91%)
Frame = +2
Query: 434 VTFALYGDGAANQGQLFEAYNMS 502
V +A YGDGAANQGQ++E++NM+
Sbjct: 172 VCYAFYGDGAANQGQVWESFNMA 194
>UniRef50_Q4WHM5 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit, putative; n=1; Aspergillus fumigatus|Rep:
Pyruvate dehydrogenase E1 component alpha subunit,
putative - Aspergillus fumigatus (Sartorya fumigata)
Length = 360
Score = 80.2 bits (189), Expect = 4e-14
Identities = 33/56 (58%), Positives = 44/56 (78%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVAFAHKY 419
G S++ ++ EL GR+ G S GKGGSMH++ F+GGNGIVGA VP+GAG+AFA +Y
Sbjct: 137 GGSIMSIVGELLGRQDGISHGKGGSMHMFCAGFFGGNGIVGAHVPVGAGIAFAQQY 192
Score = 72.9 bits (171), Expect = 7e-12
Identities = 32/57 (56%), Positives = 43/57 (75%)
Frame = +1
Query: 85 RRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCHGWTYLMG 255
+R+E A+ LYK+K IRGFCHL +GQEAVAVG+ + D +ITAYR HG+T++ G
Sbjct: 81 QRLEIAADALYKQKKIRGFCHLSTGQEAVAVGIEYGISKEDKLITAYRSHGFTFMRG 137
Score = 47.2 bits (107), Expect = 4e-04
Identities = 22/42 (52%), Positives = 27/42 (64%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
PVG+ Q R +T YGDGAANQGQ+ EA+NM+KL
Sbjct: 181 PVGAGIAFAQQYNDRDNITVDAYGDGAANQGQVHEAFNMAKL 222
>UniRef50_Q1EGH8 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=1; Nyctotherus ovalis|Rep: Pyruvate dehydrogenase E1
alpha subunit - Nyctotherus ovalis
Length = 136
Score = 79.4 bits (187), Expect = 8e-14
Identities = 34/71 (47%), Positives = 45/71 (63%)
Frame = +1
Query: 25 TSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDA 204
T A ++ LK Y + RR+E +YK+K +RGFCHL GQEAV+VG+ A +
Sbjct: 41 TKAQTNRDEMLKYYHDMNFQRRVEIMCDEIYKKKEVRGFCHLMDGQEAVSVGVEAGITKE 100
Query: 205 DSVITAYRCHG 237
D +ITAYRCHG
Sbjct: 101 DHLITAYRCHG 111
>UniRef50_Q2S150 Cluster: Pyruvate dehydrogenase E1 component, alpha
subunit; n=1; Salinibacter ruber DSM 13855|Rep: Pyruvate
dehydrogenase E1 component, alpha subunit - Salinibacter
ruber (strain DSM 13855)
Length = 470
Score = 78.6 bits (185), Expect = 1e-13
Identities = 37/73 (50%), Positives = 52/73 (71%), Gaps = 2/73 (2%)
Frame = +3
Query: 237 MDLSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVAFA 410
M L+ G++ ++EL G+ TGCS+GKGGSMH + + GG+ IVGA +PLGAG+AFA
Sbjct: 213 MGLAMGITPEAGMAELFGKETGCSKGKGGSMHFFDAEKKMMGGHAIVGAHLPLGAGLAFA 272
Query: 411 HKYRADGESRSLC 449
HKYR + ++ LC
Sbjct: 273 HKYRGE-DNVCLC 284
Score = 59.7 bits (138), Expect = 7e-08
Identities = 31/75 (41%), Positives = 42/75 (56%), Gaps = 1/75 (1%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG-MRAAMRDADSV 213
+ ++ L L + + RR E +Y+ + I GF HLY GQEAV+ G + A DSV
Sbjct: 145 IADDEVLDLLRNMLLQRRFENRCRQMYQRQKISGFLHLYIGQEAVSTGSVNAIELGDDSV 204
Query: 214 ITAYRCHGWTYLMGL 258
ITAYR HG MG+
Sbjct: 205 ITAYRDHGMGLAMGI 219
Score = 50.0 bits (114), Expect = 5e-05
Identities = 25/60 (41%), Positives = 36/60 (60%), Gaps = 3/60 (5%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRG---DYVPGVWVDGMDVLATREAARFAIE 681
+LP VFVCENN Y MGT+VDR+ + + + G D+ P GMDV + +A + +E
Sbjct: 307 ELPIVFVCENNQYAMGTAVDRAFSKPDLFKHGYNFDF-PASLASGMDVFSVNKAVQDHVE 365
>UniRef50_A7CXZ4 Cluster: Pyruvate dehydrogenase; n=1; Opitutaceae
bacterium TAV2|Rep: Pyruvate dehydrogenase - Opitutaceae
bacterium TAV2
Length = 365
Score = 77.0 bits (181), Expect = 4e-13
Identities = 32/59 (54%), Positives = 46/59 (77%), Gaps = 2/59 (3%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHLY--GRNFYGGNGIVGAQVPLGAGVAFAHKYR 422
G+ +++EL G+ TGCS+GKGGSMH + +N++GG+GIVG Q+PLG G+A+A KYR
Sbjct: 103 GMDTKALMAELYGKATGCSKGKGGSMHYFDPSKNYWGGHGIVGGQIPLGTGLAYAVKYR 161
Score = 68.5 bits (160), Expect = 1e-10
Identities = 36/77 (46%), Positives = 46/77 (59%)
Frame = +1
Query: 28 SATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDAD 207
+A LT ++LY + +RR E S Y+ K I GF HLY GQEAVAVG + M + D
Sbjct: 28 NADLTPAARIELYRTMVRIRRFEERSLRAYQAKKIGGFLHLYIGQEAVAVGCCSLMGEHD 87
Query: 208 SVITAYRCHGWTYLMGL 258
VITAYR HG +G+
Sbjct: 88 HVITAYRDHGHAIAVGM 104
Score = 46.8 bits (106), Expect = 5e-04
Identities = 26/51 (50%), Positives = 30/51 (58%), Gaps = 2/51 (3%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVW--VDGMDVLATR 657
DLPC+FV ENNGY MGTS RSSA E TR W ++G D+ R
Sbjct: 192 DLPCIFVIENNGYSMGTSQARSSAG-ELATRAAGYDMKWETINGHDLYEVR 241
Score = 35.9 bits (79), Expect = 0.94
Identities = 23/66 (34%), Positives = 31/66 (46%), Gaps = 2/66 (3%)
Frame = +2
Query: 317 GRFHAFVRTQLLWWQRDCWCAGPVGSWSGLRPQVPRR--RGVTFALYGDGAANQGQLFEA 490
G H F ++ W G + +GL V R +G A GDGA NQG + EA
Sbjct: 126 GSMHYFDPSKNYWGGHGI-VGGQIPLGTGLAYAVKYRGLKGSAMAFMGDGAVNQGAVHEA 184
Query: 491 YNMSKL 508
YN++ L
Sbjct: 185 YNLAAL 190
>UniRef50_Q9Z8N4 Cluster: Pyruvate Dehydrogenase Alpha; n=8;
Chlamydiaceae|Rep: Pyruvate Dehydrogenase Alpha -
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Length = 342
Score = 74.9 bits (176), Expect = 2e-12
Identities = 33/60 (55%), Positives = 41/60 (68%)
Frame = +3
Query: 270 VLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVAFAHKYRADGESRSLC 449
+ +EL G+ TGC+ G+GGSMH+ G NF GG GIVG Q+PL AG AF KY+ SLC
Sbjct: 104 IAAELLGKETGCALGRGGSMHMCGPNFPGGFGIVGGQIPLAAGAAFTIKYQEQKNRVSLC 163
Score = 49.2 bits (112), Expect = 9e-05
Identities = 23/68 (33%), Positives = 35/68 (51%)
Frame = +1
Query: 55 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 234
+K +Q+ ++R E Y E ++ GF H Y+GQEAVA A V ++YRCH
Sbjct: 32 IKFLKQMVLIREFEARGEEAYLEGLVGGFYHSYAGQEAVATAAIANTGLDPWVFSSYRCH 91
Query: 235 GWTYLMGL 258
L+ +
Sbjct: 92 ALAILLNI 99
Score = 35.9 bits (79), Expect = 0.94
Identities = 24/72 (33%), Positives = 37/72 (51%), Gaps = 7/72 (9%)
Frame = +1
Query: 487 SLQHV*TRDLPCVFVCENNGYGMGTSVDRSSAS---TEYYTRGDYVPGVWVDGMD----V 645
+L V LP + + ENNG+ MGTS++R+ A E + V V+G D +
Sbjct: 178 TLNFVSLHQLPLMLIIENNGWSMGTSLNRAVAKQPIAESQGSSYDIRAVTVNGFDLFNSL 237
Query: 646 LATREAARFAIE 681
L REA R+ ++
Sbjct: 238 LGFREAYRYMVD 249
>UniRef50_Q12FH4 Cluster: Pyruvate dehydrogenase; n=37;
Bacteria|Rep: Pyruvate dehydrogenase - Polaromonas sp.
(strain JS666 / ATCC BAA-500)
Length = 337
Score = 74.1 bits (174), Expect = 3e-12
Identities = 33/60 (55%), Positives = 45/60 (75%), Gaps = 2/60 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVAFAHK 416
L G+++ G+++E+ G+R GCSRG+GGSMHL+ R FYGGN IVG +PL AG+A A K
Sbjct: 85 LLRGLAMNGIMAEMYGKREGCSRGRGGSMHLFDRATRFYGGNAIVGGGLPLAAGLALADK 144
Score = 64.1 bits (149), Expect = 3e-09
Identities = 33/73 (45%), Positives = 43/73 (58%)
Frame = +1
Query: 52 ALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRC 231
AL + + +RR+E LY E+ IRGF HLY G+EAVAVG A++ D+V+ YR
Sbjct: 21 ALAVLAGMLRIRRMEEKCAQLYGEQKIRGFLHLYIGEEAVAVGALRALQPQDNVVATYRE 80
Query: 232 HGWTYLMGLVCWG 270
HG L GL G
Sbjct: 81 HGHALLRGLAMNG 93
Score = 44.4 bits (100), Expect = 0.003
Identities = 24/54 (44%), Positives = 33/54 (61%), Gaps = 2/54 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTR-GDY-VPGVWVDGMDVLATREAAR 669
LP +F CENN Y MGT++ RS A T+ + Y + V DGMDV+A +A +
Sbjct: 178 LPVLFCCENNLYAMGTALARSEAQTDLCMKAASYGMATVQADGMDVVAVFDAVQ 231
>UniRef50_Q95VS6 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=2; Antonospora locustae|Rep: Pyruvate dehydrogenase E1
alpha subunit - Antonospora locustae (Nosema locustae)
Length = 342
Score = 72.1 bits (169), Expect = 1e-11
Identities = 32/55 (58%), Positives = 41/55 (74%)
Frame = +3
Query: 255 VSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVAFAHKY 419
+ V ++ EL GR G ++GKGGSMHLY +GG+GIVGAQVPLG G+A+A KY
Sbjct: 96 IPVREIVGELLGRAGGVAKGKGGSMHLYNDLLFGGHGIVGAQVPLGCGMAYALKY 150
Score = 52.8 bits (121), Expect = 8e-06
Identities = 25/69 (36%), Positives = 38/69 (55%)
Frame = +1
Query: 28 SATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDAD 207
S + +D KLY ++ +R ++ + +Y +IRGFCHL GQE V + R+ D
Sbjct: 21 SCKIRYDDVEKLYRKMLCMRYMDESISKMYSRGLIRGFCHLDIGQEEVYAALCHVARN-D 79
Query: 208 SVITAYRCH 234
I +YRCH
Sbjct: 80 KFIGSYRCH 88
Score = 45.6 bits (103), Expect = 0.001
Identities = 21/58 (36%), Positives = 32/58 (55%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEY 684
+LP VFV NN Y M T V + A+ ++Y R D++PG+ V G + A + E+
Sbjct: 191 NLPIVFVVVNNAYSMWTCVADACANDDFYKRADFLPGLRVLGRSIFAVTRCLEVSREH 248
Score = 39.9 bits (89), Expect = 0.058
Identities = 14/27 (51%), Positives = 22/27 (81%)
Frame = +2
Query: 428 RGVTFALYGDGAANQGQLFEAYNMSKL 508
+ V F YGDGA+NQGQ+ E++N++K+
Sbjct: 163 KAVVFCFYGDGASNQGQIHESFNVAKI 189
>UniRef50_Q42066 Cluster: Pyruvate dehydrogenase E1 componen; n=5;
Eukaryota|Rep: Pyruvate dehydrogenase E1 componen -
Arabidopsis thaliana (Mouse-ear cress)
Length = 127
Score = 71.7 bits (168), Expect = 2e-11
Identities = 30/54 (55%), Positives = 37/54 (68%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARF 672
D P + VCENN YGMGT R++ S YY RGDYVPG+ VDGMD ++A +F
Sbjct: 16 DXPAILVCENNHYGMGTXEWRAAKSPSYYKRGDYVPGLKVDGMDAFPVKQACKF 69
>UniRef50_A6DTS3 Cluster: Dehydrogenase complex, E1 component, alpha
subunit; n=1; Lentisphaera araneosa HTCC2155|Rep:
Dehydrogenase complex, E1 component, alpha subunit -
Lentisphaera araneosa HTCC2155
Length = 320
Score = 71.3 bits (167), Expect = 2e-11
Identities = 33/71 (46%), Positives = 44/71 (61%)
Frame = +1
Query: 46 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAY 225
E AL++ EQ+ +RR E Y++K I GFCH Y GQEAVAVG A + D+ +T+Y
Sbjct: 7 EKALQMLEQMIRVRRFEEGCLKSYQQKFITGFCHTYIGQEAVAVGAMAHLTPTDAYVTSY 66
Query: 226 RCHGWTYLMGL 258
RCH + GL
Sbjct: 67 RCHAQGLIGGL 77
Score = 71.3 bits (167), Expect = 2e-11
Identities = 31/58 (53%), Positives = 44/58 (75%), Gaps = 2/58 (3%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVAFAHKY 419
G++ V++E+ G+ TGC RGKGGSMH++ + N+ GG+GIVG Q+P+G G AFA KY
Sbjct: 76 GLTSREVMAEMFGKITGCVRGKGGSMHVFSKKNNYLGGHGIVGGQIPIGLGAAFALKY 133
Score = 48.0 bits (109), Expect = 2e-04
Identities = 25/61 (40%), Positives = 37/61 (60%), Gaps = 2/61 (3%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEY--YTRGDYVPGVWVDGMDVLATREAARFAIEY 684
D+P +F+CENN YGMGTS DR+ A+ + + + G VDGM++ A+ +A I
Sbjct: 165 DVPVIFICENNQYGMGTSNDRALANPQVSDFAAAYKMKGYEVDGMNLEASYKAFGEIIAD 224
Query: 685 C 687
C
Sbjct: 225 C 225
Score = 32.7 bits (71), Expect = 8.8
Identities = 13/42 (30%), Positives = 22/42 (52%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
P+G + + + GV +GDGA+ QG E+ N++ L
Sbjct: 122 PIGLGAAFALKYEEKEGVALTFFGDGASMQGTFHESLNLASL 163
>UniRef50_A6GG24 Cluster: Pyruvate dehydrogenase (Lipoamide), alpha
subunit; n=1; Plesiocystis pacifica SIR-1|Rep: Pyruvate
dehydrogenase (Lipoamide), alpha subunit - Plesiocystis
pacifica SIR-1
Length = 339
Score = 69.7 bits (163), Expect = 6e-11
Identities = 50/198 (25%), Positives = 80/198 (40%), Gaps = 3/198 (1%)
Frame = +1
Query: 19 PATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMR 198
P T + ++ LK + ++ +RR E + Y I GF HLY GQEA+AVG++ AM+
Sbjct: 11 PETLTSAGKDETLKAFREMLRIRRFEETAARAYTRGKISGFLHLYIGQEAIAVGVKLAMQ 70
Query: 199 DADSVITAYRCHGWTYLMGLVCWGCSRS*RGAGPVAPGAREVPCICTDATSMVATGLLVR 378
D V+ YR HG+ G C G G D + + G +
Sbjct: 71 ANDRVVGTYRDHGYALAQGSDANACMAELFGKATGLVGGVGGSMHYFDRPNGLWGGYAII 130
Query: 379 RSRWELEWPSPTSTAPTGSHXXXXXXXXXQP---GSTLRSLQHV*TRDLPCVFVCENNGY 549
+ + ++ G G T + DLP +++ ENN Y
Sbjct: 131 GNHVPVAAGHAFASKYLGDDAVTMCFLGDGAVGIGPTHEGMTLAGLWDLPVIYIVENNRY 190
Query: 550 GMGTSVDRSSASTEYYTR 603
MGT ++R+ + + R
Sbjct: 191 SMGTPLERTLPTEDITAR 208
Score = 54.8 bits (126), Expect = 2e-06
Identities = 29/71 (40%), Positives = 41/71 (57%), Gaps = 2/71 (2%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVAFAHK 416
L+ G ++EL G+ TG G GGSMH + R +GG I+G VP+ AG AFA K
Sbjct: 86 LAQGSDANACMAELFGKATGLVGGVGGSMHYFDRPNGLWGGYAIIGNHVPVAAGHAFASK 145
Query: 417 YRADGESRSLC 449
Y D ++ ++C
Sbjct: 146 YLGD-DAVTMC 155
>UniRef50_P27745 Cluster: Acetoin:2,6-dichlorophenolindophenol
oxidoreductase subunit alpha; n=58; cellular
organisms|Rep: Acetoin:2,6-dichlorophenolindophenol
oxidoreductase subunit alpha - Ralstonia eutropha
(strain ATCC 17699 / H16 / DSM 428 / Stanier
337)(Cupriavidus necator (strain ATCC 17699 / H16 / DSM
428 / Stanier337))
Length = 333
Score = 68.9 bits (161), Expect = 1e-10
Identities = 61/215 (28%), Positives = 85/215 (39%), Gaps = 5/215 (2%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 216
L E L +Y ++ +R E + I GF HLY+G+EA VG+ + D D +
Sbjct: 14 LDKETLLTVYRKMRTIRDFEERLHVDFGRGDIPGFVHLYAGEEAAGVGILHHLNDGDRIA 73
Query: 217 TAYRCHGWTYLMGLVCWGCSRS*RGAGPVAPGAREVPCICTDATS--MVATGLLVRRSRW 390
+ +R HG G+ + G + + D + M A G+L +
Sbjct: 74 STHRGHGHCIAKGVDPVAMMKEIYGKKGGSCNGKGGSMHIADLSKGMMGANGILGAGAPL 133
Query: 391 ELEWPSPTSTAPTGS-HXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMGTSV 567
G G+ L SL +LP +FV ENNGY TS
Sbjct: 134 ICGAALAAKFRGKGEVGITFCGDGASNQGTFLESLNLAAVWNLPVIFVIENNGYAESTSR 193
Query: 568 DRSSASTEYYTR--GDYVPGVWVDGMDVLATREAA 666
D +A Y R G +PGV VDG D A EAA
Sbjct: 194 DYGTAVDSYVDRAAGFGIPGVTVDGTDFFAVHEAA 228
Score = 57.6 bits (133), Expect = 3e-07
Identities = 27/66 (40%), Positives = 39/66 (59%), Gaps = 2/66 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHK 416
++ GV + ++ E+ G++ G GKGGSMH+ + G NGI+GA PL G A A K
Sbjct: 83 IAKGVDPVAMMKEIYGKKGGSCNGKGGSMHIADLSKGMMGANGILGAGAPLICGAALAAK 142
Query: 417 YRADGE 434
+R GE
Sbjct: 143 FRGKGE 148
>UniRef50_Q1ATM5 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacter
xylanophilus DSM 9941|Rep: Pyruvate dehydrogenase -
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 353
Score = 68.5 bits (160), Expect = 1e-10
Identities = 33/62 (53%), Positives = 43/62 (69%), Gaps = 2/62 (3%)
Frame = +3
Query: 270 VLSELTGRRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVAFAHKYRADGESRS 443
V++EL G+RTG +GKGGSMHL+ R F GG GIVG +PLG G+A+A +Y G S
Sbjct: 101 VMAELFGKRTGLVKGKGGSMHLFDVERGFMGGYGIVGGHIPLGVGIAYALRY---GGSEG 157
Query: 444 LC 449
+C
Sbjct: 158 IC 159
Score = 65.7 bits (153), Expect = 1e-09
Identities = 33/77 (42%), Positives = 46/77 (59%), Gaps = 1/77 (1%)
Frame = +1
Query: 28 SATLTSEDAL-KLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDA 204
SA TS D L +LY ++ ++R E A +++ I G+ H+Y+GQEAVA G A R+
Sbjct: 19 SAVATSPDRLAELYGKMVLIRAFEDACQRAFRQGKIGGYLHVYTGQEAVATGFLEAFREG 78
Query: 205 DSVITAYRCHGWTYLMG 255
D VIT YR H L+G
Sbjct: 79 DRVITGYRDHAHALLLG 95
Score = 47.6 bits (108), Expect = 3e-04
Identities = 26/57 (45%), Positives = 33/57 (57%), Gaps = 2/57 (3%)
Frame = +1
Query: 517 PCVFVCENNGYGMGTSVDRSSASTEYYTR-GDYVPG-VWVDGMDVLATREAARFAIE 681
PC F+ ENN YGMGTSV+R++A T+ + Y G VDGMD+ A E E
Sbjct: 190 PCFFIVENNQYGMGTSVERATAMTDLAAKFNSYAIGNEKVDGMDLEAVIECGERVAE 246
>UniRef50_Q74AD3 Cluster: Dehydrogenase complex, E1 component, alpha
subunit; n=5; Geobacter|Rep: Dehydrogenase complex, E1
component, alpha subunit - Geobacter sulfurreducens
Length = 325
Score = 68.1 bits (159), Expect = 2e-10
Identities = 33/75 (44%), Positives = 45/75 (60%)
Frame = +1
Query: 31 ATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADS 210
A L + LK++EQ+ + R E + Y + I GF HLYSGQEAVAVG AA+R D
Sbjct: 7 AILPDSELLKMHEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAALRKDDY 66
Query: 211 VITAYRCHGWTYLMG 255
+++AYR H + G
Sbjct: 67 ILSAYREHAQAIVRG 81
Score = 64.5 bits (150), Expect = 2e-09
Identities = 30/56 (53%), Positives = 39/56 (69%), Gaps = 2/56 (3%)
Frame = +3
Query: 270 VLSELTGRRTGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVAFAHKYRADG 431
V++EL G+ TG +GKGGSMHL+ + F GG IVG Q P+ G+AFA KYR +G
Sbjct: 87 VMAELFGKATGMCKGKGGSMHLFDPSLAFMGGYAIVGGQFPIAVGLAFASKYRKEG 142
Score = 63.7 bits (148), Expect = 4e-09
Identities = 29/60 (48%), Positives = 43/60 (71%), Gaps = 2/60 (3%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTR--GDYVPGVWVDGMDVLATREAARFAIEY 684
+LP +F+CENN YG+GT+V R+SA ++ + R G +P V VDGMDV+A EA ++ E+
Sbjct: 170 ELPVLFICENNFYGIGTAVSRASALSDIHKRTCGYDIPSVRVDGMDVMAVHEAVKWGAEW 229
>UniRef50_Q1KSF1 Cluster: Apicoplast pyruvate dehydrogenase E1 alpha
subunit; n=1; Toxoplasma gondii|Rep: Apicoplast pyruvate
dehydrogenase E1 alpha subunit - Toxoplasma gondii
Length = 635
Score = 66.5 bits (155), Expect = 6e-10
Identities = 30/61 (49%), Positives = 41/61 (67%), Gaps = 2/61 (3%)
Frame = +3
Query: 246 SHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVAFAHKY 419
S GV V V++EL G+ TGCSRG+GGSMH++ + N GG +G Q+P+ G AF+ Y
Sbjct: 323 SKGVPVREVMAELFGKATGCSRGRGGSMHMFSKKHNMIGGFAFIGEQIPVALGYAFSAAY 382
Query: 420 R 422
R
Sbjct: 383 R 383
Score = 56.4 bits (130), Expect = 6e-07
Identities = 31/58 (53%), Positives = 38/58 (65%), Gaps = 2/58 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAIE 681
LP VFV ENN + +G + RS+A+ + R D V GV VDGMDVLA R AAR AI+
Sbjct: 425 LPIVFVVENNNWAIGMAAQRSTATPAVWQRADSFGVAGVEVDGMDVLAVRGAARRAID 482
Score = 49.2 bits (112), Expect = 9e-05
Identities = 24/58 (41%), Positives = 33/58 (56%)
Frame = +1
Query: 61 LYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 234
L E + R +E A LY GF HLY+GQEAV+ G+ +R D+V++ YR H
Sbjct: 261 LLEDMLTGRMVEDACARLYYMGKTAGFVHLYTGQEAVSAGVIKLLRPDDAVVSTYRDH 318
>UniRef50_Q83X26 Cluster: Probable pyruvate dehydrogenase
alpha-subunit; n=1; Streptomyces rochei|Rep: Probable
pyruvate dehydrogenase alpha-subunit - Streptomyces
rochei (Streptomyces parvullus)
Length = 326
Score = 66.1 bits (154), Expect = 8e-10
Identities = 65/221 (29%), Positives = 92/221 (41%), Gaps = 9/221 (4%)
Frame = +1
Query: 58 KLYEQLTILRRIETASGNLYK-EKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 234
+L + +R IE ++Y+ E+ +R HL GQEAVAVG+ AA+R D V + +RCH
Sbjct: 5 QLLRTMVRIRCIEEEIADVYRDEQQMRTPVHLSIGQEAVAVGVCAALRTEDVVYSGHRCH 64
Query: 235 GWTYLM---GLVCWGCSRS*RGAGPVAPGAREVPCICTDATSMVATGLL--VRRSRWELE 399
YL GL R G A V + A ++ +L +
Sbjct: 65 A-HYLAKGGGLGAMVAELYGRETGCAAGRGGSVHLVDEAAGFGASSAILGEMISVATGAA 123
Query: 400 WPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMGTSV---D 570
W AP + + G SL LP V+VCENN Y + + +
Sbjct: 124 WAFARQEAPRVA-VTFFGDGASEEGVFHESLNFAALHRLPVVYVCENNQYSLSSPLAARQ 182
Query: 571 RSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEYCNA 693
S RG +P VDG DV A AA A+E+C +
Sbjct: 183 PPGTSISGRARGYGIPAARVDGNDVAAVHAAAVTAVEHCRS 223
Score = 44.0 bits (99), Expect = 0.004
Identities = 21/58 (36%), Positives = 34/58 (58%), Gaps = 2/58 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLY--GRNFYGGNGIVGAQVPLGAGVAFA 410
L+ G + +++EL GR TGC+ G+GGS+HL F + I+G + + G A+A
Sbjct: 68 LAKGGGLGAMVAELYGRETGCAAGRGGSVHLVDEAAGFGASSAILGEMISVATGAAWA 125
>UniRef50_Q2ITF8 Cluster: Acetoin dehydrogenase (TPP-dependent)
alpha chain; n=1; Rhodopseudomonas palustris HaA2|Rep:
Acetoin dehydrogenase (TPP-dependent) alpha chain -
Rhodopseudomonas palustris (strain HaA2)
Length = 323
Score = 65.3 bits (152), Expect = 1e-09
Identities = 37/90 (41%), Positives = 52/90 (57%), Gaps = 2/90 (2%)
Frame = +3
Query: 171 GSRYESSDARCRLSNHRVSLSRMDLSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRN- 347
G+ E +D +S HR L+ G S+ +++E+ GR TGCSRGKGGSMHL +
Sbjct: 49 GAALEPADLA--VSGHRAHAHY--LAKGGSLKAMIAEIYGRVTGCSRGKGGSMHLIDESA 104
Query: 348 -FYGGNGIVGAQVPLGAGVAFAHKYRADGE 434
F G IVG VP+G G+A+ K + G+
Sbjct: 105 GFMGSTAIVGGTVPVGVGLAYPMKLKRTGQ 134
Score = 41.5 bits (93), Expect = 0.019
Identities = 43/174 (24%), Positives = 65/174 (37%), Gaps = 3/174 (1%)
Frame = +1
Query: 43 SEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITA 222
SE +L + +R +E Y E+ +R HL GQEAVA AA+ AD ++
Sbjct: 2 SELPRRLLFDMMRIRAVEETIAKRYGEQKMRCPTHLSVGQEAVAAAAGAALEPADLAVSG 61
Query: 223 YRCHGWTYLMG--LVCWGCSRS*RGAGPVAPGAREVPCICTDATSMVATGLLVRRSRWEL 396
+R H G L R G + I A M +T ++ +
Sbjct: 62 HRAHAHYLAKGGSLKAMIAEIYGRVTGCSRGKGGSMHLIDESAGFMGSTAIVGGTVPVGV 121
Query: 397 EWPSPTSTAPTGS-HXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGM 555
P TG + G ++ + LP +F+CENNGY +
Sbjct: 122 GLAYPMKLKRTGQIACVFLGDAVPETGVFFEAVNFAVLKKLPVLFLCENNGYSV 175
>UniRef50_A5V540 Cluster: Dehydrogenase, E1 component; n=3;
Proteobacteria|Rep: Dehydrogenase, E1 component -
Sphingomonas wittichii RW1
Length = 334
Score = 65.3 bits (152), Expect = 1e-09
Identities = 58/227 (25%), Positives = 89/227 (39%), Gaps = 4/227 (1%)
Frame = +1
Query: 13 QGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAA 192
+G A + + ++LY ++ +R E + G L+ I GF HL GQE V+VG+ A+
Sbjct: 10 RGAAHGRNARAPELIELYRRMVTIREAEKSCGALFAAGEIPGFIHLSDGQEGVSVGVMAS 69
Query: 193 MRDADSVITAYRCHGWTYLMGLVCWGCSRS*RGAGPVAPGAREVPCICTDAT--SMVATG 366
+R D++ + +R HG GL G R G A R D + + A G
Sbjct: 70 LRADDTIASTHRGHGHALAKGLGLDGFFRELMGKADGACKGRGGSMHVADLSVGMLGANG 129
Query: 367 LLVRRSRWEL-EWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENN 543
++ L + G G SL + +P +FVCENN
Sbjct: 130 IVGGGVAIALGSGLAQKLRGGDGLAICFFGDGALAEGIVHESLNIAQLKQIPILFVCENN 189
Query: 544 GYGMGTSVDRSSASTEYYTRGDY-VPGVWVDGMDVLATREAARFAIE 681
G+ + T Y +P V DG DV E A ++
Sbjct: 190 GWSEFSPTSTQVTFTLEKLAAAYGIPYVGADGSDVETVAELAADVVD 236
Score = 48.8 bits (111), Expect = 1e-04
Identities = 26/71 (36%), Positives = 37/71 (52%), Gaps = 2/71 (2%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHK 416
L+ G+ + G EL G+ G +G+GGSMH+ G NGIVG V + G A K
Sbjct: 87 LAKGLGLDGFFRELMGKADGACKGRGGSMHVADLSVGMLGANGIVGGGVAIALGSGLAQK 146
Query: 417 YRADGESRSLC 449
R G+ ++C
Sbjct: 147 LRG-GDGLAIC 156
>UniRef50_Q2WB98 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex; n=1; Magnetospirillum magneticum AMB-1|Rep:
Pyruvate/2-oxoglutarate dehydrogenase complex -
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Length = 647
Score = 64.9 bits (151), Expect = 2e-09
Identities = 32/75 (42%), Positives = 46/75 (61%)
Frame = +3
Query: 207 LSNHRVSLSRMDLSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVP 386
LSNHR + + V G+++E+ GR +G RG+GGS HL G+ F+ NGI+G P
Sbjct: 63 LSNHRGHGHYLAWTDDVE--GLIAEVMGRESGVCRGRGGSQHLRGQGFF-SNGIIGGMAP 119
Query: 387 LGAGVAFAHKYRADG 431
+ AG+A AH+ DG
Sbjct: 120 VAAGLAMAHRLAGDG 134
Score = 37.9 bits (84), Expect = 0.23
Identities = 18/54 (33%), Positives = 30/54 (55%)
Frame = +1
Query: 76 TILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCHG 237
T++R +E +LY E + G H GQE V + +A+R D +++ +R HG
Sbjct: 17 TLIRVVEERLLSLYGEGRLHGTVHTCIGQEWTGVSVASALRSGDYILSNHRGHG 70
>UniRef50_Q6MAE2 Cluster: Putative pyruvate dehydrogenase
(Lipoamide), E1 component, alpha chain; n=1; Candidatus
Protochlamydia amoebophila UWE25|Rep: Putative pyruvate
dehydrogenase (Lipoamide), E1 component, alpha chain -
Protochlamydia amoebophila (strain UWE25)
Length = 342
Score = 62.1 bits (144), Expect = 1e-08
Identities = 27/60 (45%), Positives = 39/60 (65%)
Frame = +3
Query: 270 VLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVAFAHKYRADGESRSLC 449
+++EL GR TG ++G+GGSMH + GG GIV QVP+ G AFA KY+ + ++C
Sbjct: 99 LMAELYGRATGNAKGRGGSMHFFTDRLLGGFGIVTGQVPIATGAAFALKYKGNKNEVAVC 158
Score = 48.0 bits (109), Expect = 2e-04
Identities = 21/67 (31%), Positives = 37/67 (55%)
Frame = +1
Query: 55 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 234
++ ++Q+ +R E + + Y++ I GF H Y GQEA+ A+ ++ T+YRCH
Sbjct: 27 IECFQQMLKIRNFELRAESAYQQGKIGGFFHAYVGQEAIQTAAVQAIGQSNWYATSYRCH 86
Query: 235 GWTYLMG 255
L+G
Sbjct: 87 ALALLLG 93
Score = 36.7 bits (81), Expect = 0.54
Identities = 21/60 (35%), Positives = 31/60 (51%), Gaps = 3/60 (5%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRS---SASTEYYTRGDYVPGVWVDGMD 642
GS SL +LPC++V ENN +GMGT++ ++ E G + +DGMD
Sbjct: 168 GSFHESLNLASLWNLPCIYVIENNQWGMGTAIQKAVSVKRLAEDKASGYNMKAYTLDGMD 227
>UniRef50_Q97YF6 Cluster: Pyruvate dehydrogenase, alpha subunit
(Lipoamide); n=2; Sulfolobaceae|Rep: Pyruvate
dehydrogenase, alpha subunit (Lipoamide) - Sulfolobus
solfataricus
Length = 345
Score = 62.1 bits (144), Expect = 1e-08
Identities = 33/84 (39%), Positives = 49/84 (58%), Gaps = 1/84 (1%)
Frame = +3
Query: 171 GSRYESSDARCRLSNHRVSLSRMDLSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRN- 347
G+ Y+ D +S HR ++ GV + G+ +E+ G+ TG +GKGG MHL+ ++
Sbjct: 77 GTLYDIRDEDVVVSTHRPH--HHAIAKGVDLKGLAAEILGKATGLCKGKGGHMHLFDKSK 134
Query: 348 FYGGNGIVGAQVPLGAGVAFAHKY 419
+ +GIVGA P AG AFA KY
Sbjct: 135 NFACSGIVGASFPQAAGAAFAFKY 158
Score = 46.0 bits (104), Expect = 9e-04
Identities = 29/78 (37%), Positives = 42/78 (53%), Gaps = 9/78 (11%)
Frame = +1
Query: 28 SATLTSEDALKLYEQLTILRRIETASGNLYKEKI---------IRGFCHLYSGQEAVAVG 180
+A L + D L +Y+++ I+R E + +Y E IRG HL GQEAVAVG
Sbjct: 18 NAGLKASDLLNMYKRMLIIRYFEESIRKIYHEGKNPFNMASGRIRGEMHLSIGQEAVAVG 77
Query: 181 MRAAMRDADSVITAYRCH 234
+RD D V++ +R H
Sbjct: 78 TLYDIRDEDVVVSTHRPH 95
Score = 37.9 bits (84), Expect = 0.23
Identities = 23/59 (38%), Positives = 32/59 (54%), Gaps = 2/59 (3%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRG-DY-VPGVWVDGMDVLATREAARFAIE 681
+LP + V E+N Y T ++T +Y RG Y VP VDGMDV+ ++ AIE
Sbjct: 190 ELPLIIVIEDNKYADSTPKSFVMSTTFHYQRGLAYNVPSYLVDGMDVIDVYSTSKKAIE 248
>UniRef50_Q1XDM0 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=52; cellular organisms|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Porphyra
yezoensis
Length = 346
Score = 61.7 bits (143), Expect = 2e-08
Identities = 28/62 (45%), Positives = 38/62 (61%), Gaps = 2/62 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVAFAHK 416
LS GV V++EL G+ TGCS+G+GGSMH++ NF GG + +P+ G AF
Sbjct: 90 LSKGVPSKNVMAELFGKETGCSKGRGGSMHIFSAPHNFLGGFAFIAEGIPVATGAAFQSI 149
Query: 417 YR 422
YR
Sbjct: 150 YR 151
Score = 53.6 bits (123), Expect = 4e-06
Identities = 26/58 (44%), Positives = 40/58 (68%), Gaps = 2/58 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAIE 681
LP +FV ENN + +G + RSS+ E + + + +PG+ VDGMDVLA R+AA+ A++
Sbjct: 190 LPIIFVVENNQWAIGMAHHRSSSIPEIHKKAEAFGLPGIEVDGMDVLAVRQAAKQAVQ 247
Score = 51.6 bits (118), Expect = 2e-05
Identities = 25/71 (35%), Positives = 37/71 (52%)
Frame = +1
Query: 22 ATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRD 201
+T L + L LYE + + R E +Y + + GF HLY+GQEAV+ G+ +
Sbjct: 16 STGLNLNKSNLLVLYEDMLLGRNFEDMCAQMYYKGKMFGFVHLYNGQEAVSTGVIKLLNP 75
Query: 202 ADSVITAYRCH 234
D V + YR H
Sbjct: 76 TDYVCSTYRDH 86
>UniRef50_A5UU15 Cluster: Pyruvate dehydrogenase; n=3; Chloroflexi
(class)|Rep: Pyruvate dehydrogenase - Roseiflexus sp.
RS-1
Length = 350
Score = 60.9 bits (141), Expect = 3e-08
Identities = 30/74 (40%), Positives = 39/74 (52%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 216
L + + Y Q+ ++RR E +Y I GF HLY G+EA AVG AA+R D +
Sbjct: 21 LDAATLIDYYRQMVLIRRFEEKCQEMYTRAKIGGFLHLYIGEEATAVGAIAALRPDDHIF 80
Query: 217 TAYRCHGWTYLMGL 258
T YR HG GL
Sbjct: 81 THYRDHGHAIARGL 94
Score = 60.5 bits (140), Expect = 4e-08
Identities = 27/60 (45%), Positives = 40/60 (66%), Gaps = 2/60 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHK 416
++ G+ + +++EL G+ TGCS+G GGSMH +NF+GG IVG+ +PL GVA K
Sbjct: 90 IARGLDINALMAELFGKVTGCSKGLGGSMHFADASKNFWGGYAIVGSHLPLATGVALGMK 149
Score = 51.2 bits (117), Expect = 2e-05
Identities = 31/76 (40%), Positives = 40/76 (52%), Gaps = 2/76 (2%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDV 645
G SL LP VFVCENN Y MGT ++ S+ TE Y + + VDG DV
Sbjct: 169 GEFYESLNFAQLWKLPVVFVCENNLYAMGTPLEVHSSVTEIYRKACAFDMKAERVDGNDV 228
Query: 646 LATREAARFAIEYCNA 693
L REA+ A+E+ +
Sbjct: 229 LVMREASLRAVEHARS 244
>UniRef50_A3VIE7 Cluster: Tpp-dependent acetoin dehydrogenase e1
alpha-subunit; n=2; Rhodobacterales|Rep: Tpp-dependent
acetoin dehydrogenase e1 alpha-subunit - Rhodobacterales
bacterium HTCC2654
Length = 335
Score = 59.7 bits (138), Expect = 7e-08
Identities = 31/79 (39%), Positives = 45/79 (56%)
Frame = +1
Query: 1 HKLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG 180
H + A S T T ED L++Y Q+ +R E + LY + G H+YSG+EAVAVG
Sbjct: 5 HLREDTMAKSKTNT-EDYLRMYRQMVRIRTFEDNANQLYLSAKMPGLTHMYSGEEAVAVG 63
Query: 181 MRAAMRDADSVITAYRCHG 237
+ A+ D D + + +R HG
Sbjct: 64 ICEALTDDDRITSTHRGHG 82
Score = 39.9 bits (89), Expect = 0.058
Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 2/66 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNF--YGGNGIVGAQVPLGAGVAFAHK 416
++ G + EL G+ G RGKGGSMH+ ++ G N IVG + + G A K
Sbjct: 85 VAKGAEFKEMFCELLGKEEGYCRGKGGSMHIADQSHGNLGANAIVGGSMGIATGSALRAK 144
Query: 417 YRADGE 434
+ +
Sbjct: 145 LQGSDD 150
Score = 37.9 bits (84), Expect = 0.23
Identities = 21/59 (35%), Positives = 27/59 (45%), Gaps = 1/59 (1%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSA-STEYYTRGDYVPGVWVDGMDVLATREAARFAIEYC 687
LP ++ CENNGY T D +A S + VDG DVLA E + + C
Sbjct: 178 LPVIYACENNGYSEYTRTDEIAAGSITARAEAFGIEAHKVDGQDVLAVNELTQKLVARC 236
Score = 33.5 bits (73), Expect = 5.0
Identities = 15/41 (36%), Positives = 23/41 (56%)
Frame = +2
Query: 386 VGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
+ + S LR ++ VT +GDGA QG ++E NM+ L
Sbjct: 135 IATGSALRAKLQGSDDVTVCFFGDGATAQGLMYEVMNMAAL 175
>UniRef50_A6Q3I6 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex, E1 component, alpha subunit; n=2; unclassified
Epsilonproteobacteria|Rep: Pyruvate/2-oxoglutarate
dehydrogenase complex, E1 component, alpha subunit -
Nitratiruptor sp. (strain SB155-2)
Length = 323
Score = 58.8 bits (136), Expect = 1e-07
Identities = 27/64 (42%), Positives = 41/64 (64%), Gaps = 2/64 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVAFAHK 416
++ G+ V++EL G+ TG S+GKGGSMHL+ +FYGG+ IV +P+ G A+A K
Sbjct: 69 IARGMDPKVVMAELFGKVTGISKGKGGSMHLFDPRLSFYGGDAIVAGHLPIATGCAYARK 128
Query: 417 YRAD 428
+
Sbjct: 129 IEGE 132
Score = 46.4 bits (105), Expect = 7e-04
Identities = 23/58 (39%), Positives = 32/58 (55%), Gaps = 1/58 (1%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRG-DYVPGVWVDGMDVLATREAARFAIEY 684
LP +F CENN Y +GT + S E + + +Y+P +DGMDV +A A EY
Sbjct: 162 LPIIFFCENNYYAIGTRIGWVSPFEELFNKAKNYMPAKRIDGMDVCEVYKAVTEAKEY 219
Score = 36.7 bits (81), Expect = 0.54
Identities = 23/57 (40%), Positives = 28/57 (49%)
Frame = +1
Query: 64 YEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 234
Y + + R E A+ Y + I GF HL GQEA +VG A D V T YR H
Sbjct: 10 YYLMKLGREFEIAAKQEYMKGNIAGFLHLDIGQEACSVGSMQAF-DKGDVFTHYREH 65
Score = 33.9 bits (74), Expect = 3.8
Identities = 19/64 (29%), Positives = 32/64 (50%), Gaps = 2/64 (3%)
Frame = +2
Query: 317 GRFHAFVRTQLLWWQRDCWCAG--PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEA 490
G H F +L ++ D AG P+ + ++ FA++GDGA+N G FE+
Sbjct: 95 GSMHLF-DPRLSFYGGDAIVAGHLPIATGCAYARKIEGENAGVFAIFGDGASNAGAFFES 153
Query: 491 YNMS 502
N++
Sbjct: 154 INIA 157
>UniRef50_Q7V0M7 Cluster: Dehydrogenase, E1 component; n=1;
Prochlorococcus marinus subsp. pastoris str.
CCMP1986|Rep: Dehydrogenase, E1 component -
Prochlorococcus marinus subsp. pastoris (strain CCMP
1378 / MED4)
Length = 324
Score = 58.4 bits (135), Expect = 2e-07
Identities = 26/60 (43%), Positives = 40/60 (66%), Gaps = 2/60 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHK 416
++ G ++ ++ EL G+ +GC+ GKGGSMH+ N +G NGIVG VP+ G+A A+K
Sbjct: 95 IAKGGNISMLIDELHGKESGCNGGKGGSMHVADLSINHFGANGIVGGGVPIACGIALANK 154
Score = 42.3 bits (95), Expect = 0.011
Identities = 20/52 (38%), Positives = 32/52 (61%)
Frame = +1
Query: 82 LRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCHG 237
+R IE A +L K+ +RG H Y G+EA+A G+ + + D+V + +R HG
Sbjct: 41 IRAIEEAIVSLAKDNKLRGPIHSYVGEEAIATGVLSHAKPIDAVTSTHRGHG 92
Score = 36.3 bits (80), Expect = 0.71
Identities = 21/72 (29%), Positives = 32/72 (44%), Gaps = 1/72 (1%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGTSV-DRSSASTEYYTRGDYVPGVWVDGMDVL 648
G L S LP VF+CENN + T + D S S ++G + + VDG+++
Sbjct: 174 GVVLESFNLAGFLSLPIVFICENNQFAQSTKLSDISLTSVAKKSQGFGIKSIEVDGLNIS 233
Query: 649 ATREAARFAIEY 684
A+ Y
Sbjct: 234 EVYSKTSDAVNY 245
Score = 35.5 bits (78), Expect = 1.2
Identities = 12/40 (30%), Positives = 25/40 (62%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMS 502
P+ L ++ ++ + F +GDGA+NQG + E++N++
Sbjct: 144 PIACGIALANKLDKKDSIVFCFFGDGASNQGVVLESFNLA 183
>UniRef50_Q3J9C5 Cluster: Dehydrogenase, E1 component; n=3;
Proteobacteria|Rep: Dehydrogenase, E1 component -
Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848)
Length = 339
Score = 58.4 bits (135), Expect = 2e-07
Identities = 28/62 (45%), Positives = 40/62 (64%), Gaps = 2/62 (3%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVAFAHKYRA 425
G V++EL G+ TG SRG+GGSMH++ + F GG +VG PL AG+A A K++
Sbjct: 78 GAPAREVMAELYGKETGSSRGRGGSMHIFDPSVRFMGGYALVGQPFPLAAGLALACKHQK 137
Query: 426 DG 431
+G
Sbjct: 138 EG 139
Score = 49.2 bits (112), Expect = 9e-05
Identities = 30/67 (44%), Positives = 35/67 (52%), Gaps = 5/67 (7%)
Frame = +1
Query: 49 DALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG---MRAAMRDA--DSV 213
D +L ++ RR E S Y E+ + GF HLYSGQEAVA G M A R D
Sbjct: 5 DRKRLLREMVFFRRFEDRSFEAYMERKVGGFLHLYSGQEAVATGVLEMVQADRGVGFDYA 64
Query: 214 ITAYRCH 234
IT YR H
Sbjct: 65 ITGYRDH 71
Score = 46.0 bits (104), Expect = 9e-04
Identities = 24/59 (40%), Positives = 34/59 (57%), Gaps = 2/59 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGD--YVPGVWVDGMDVLATREAARFAIEY 684
LP +FVCENN Y +GT + RS+A + Y R + +P G D+ EAA+ AI +
Sbjct: 168 LPVLFVCENNCYAIGTVIQRSTAVIDQYKRLEAYNIPASQHPGQDIEVVMEAAQSAIAH 226
>UniRef50_A6WG12 Cluster: Pyruvate dehydrogenase; n=3;
Actinomycetales|Rep: Pyruvate dehydrogenase -
Kineococcus radiotolerans SRS30216
Length = 390
Score = 58.4 bits (135), Expect = 2e-07
Identities = 65/228 (28%), Positives = 84/228 (36%), Gaps = 7/228 (3%)
Frame = +1
Query: 19 PATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMR 198
P L E+ L L + +LRR++ A G + + G GQEA VG A R
Sbjct: 36 PEHEVDLEPEELLALLRDMVLLRRLD-AEGEALQRQGQLGLWPGSRGQEAAQVGSATACR 94
Query: 199 DADSVITAYRCHGWTYLMGLVCWGCSRS*RGA--GPVAPGAREV-PCICTDATSM---VA 360
D V +YR HG G+ RG G P + V P A M V
Sbjct: 95 RQDQVFPSYRDHGAVLGRGIDPVDILSIFRGVDHGGWDPAEQRVHPYTLVIAAQMLPAVG 154
Query: 361 TGLLVRRSRWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCEN 540
G+ V+R TA G +L P VF+C+N
Sbjct: 155 YGMAVQRDGAVGTGDPERDTAVI----TYFGDGATSQGEAAEALNWAAVFQAPVVFLCQN 210
Query: 541 NGYGMGTSVDRSS-ASTEYYTRGDYVPGVWVDGMDVLATREAARFAIE 681
N + + V R S G +PGV VDG DVLA R A+E
Sbjct: 211 NQWAISEPVSRQSPVPLHKRAEGAGMPGVLVDGNDVLAVLAVTRAALE 258
>UniRef50_A0LSF3 Cluster: Pyruvate dehydrogenase; n=5; Bacteria|Rep:
Pyruvate dehydrogenase - Acidothermus cellulolyticus
(strain ATCC 43068 / 11B)
Length = 375
Score = 57.6 bits (133), Expect = 3e-07
Identities = 30/62 (48%), Positives = 37/62 (59%), Gaps = 2/62 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVAFAHK 416
L+ G+ V++EL GR TG S+G GGSMHL+ GG GIVG Q+P G A A
Sbjct: 105 LARGIDPGRVMAELFGRTTGVSKGWGGSMHLFDAETRLLGGYGIVGGQIPPATGAALAIA 164
Query: 417 YR 422
YR
Sbjct: 165 YR 166
Score = 57.2 bits (132), Expect = 4e-07
Identities = 28/81 (34%), Positives = 41/81 (50%), Gaps = 1/81 (1%)
Frame = +1
Query: 19 PATSATLTSEDALKLY-EQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAM 195
PA D L+ Y + ++RR E + +Y+ I G+CHL G+EA VG+ AM
Sbjct: 29 PADRLAQEPPDKLRAYYRMMQLIRRFEERAAEMYQRAKIGGYCHLNLGEEATVVGLMDAM 88
Query: 196 RDADSVITAYRCHGWTYLMGL 258
D + T YR HG+ G+
Sbjct: 89 APHDYLFTTYREHGYALARGI 109
Score = 56.8 bits (131), Expect = 5e-07
Identities = 31/57 (54%), Positives = 39/57 (68%), Gaps = 2/57 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRG-DY-VPGVWVDGMDVLATREAARFAI 678
LP V+V NN GMGT V+++SA + Y RG Y +PGV VDG DV+A REA R A+
Sbjct: 202 LPIVYVIINNQLGMGTPVEKASAEPDLYKRGCAYRIPGVRVDGNDVIACREALRDAL 258
>UniRef50_Q5VGY4 Cluster: Pyruvate dehydrogenase alpha subunit; n=6;
Plasmodium|Rep: Pyruvate dehydrogenase alpha subunit -
Plasmodium falciparum
Length = 608
Score = 57.6 bits (133), Expect = 3e-07
Identities = 28/63 (44%), Positives = 41/63 (65%), Gaps = 3/63 (4%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCS-RGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVAFAH 413
LS GV +L+EL G G + +GKGGSMH+Y + NF GG G +G Q+P+ G+A++
Sbjct: 257 LSKGVPAHKILNELYGNYYGSTNKGKGGSMHIYSKENNFIGGFGFIGEQIPIAVGLAYSI 316
Query: 414 KYR 422
Y+
Sbjct: 317 LYK 319
Score = 55.6 bits (128), Expect = 1e-06
Identities = 25/70 (35%), Positives = 40/70 (57%)
Frame = +1
Query: 25 TSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDA 204
+ ++ E+ LYE + + R E LY K + GF HLY+GQEAV+ G+ ++++
Sbjct: 184 SDVNISREEICTLYEDMYLGRLFENLVAKLYYNKRVNGFVHLYNGQEAVSTGIIKNLKNS 243
Query: 205 DSVITAYRCH 234
D V + YR H
Sbjct: 244 DFVTSTYRDH 253
Score = 35.1 bits (77), Expect = 1.6
Identities = 24/74 (32%), Positives = 36/74 (48%), Gaps = 4/74 (5%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSAS--TEYYTRGD--YVPGVWVDGM 639
G SL + +LP +FV ENN + +G RSS+ Y++G + VDG
Sbjct: 371 GQFFESLNLASSYNLPIIFVIENNNWAIGMESSRSSSDDLMNNYSKGKAFNIDTFKVDGN 430
Query: 640 DVLATREAARFAIE 681
DVL + A+ I+
Sbjct: 431 DVLTIYKLAKKKIQ 444
>UniRef50_A7HBV0 Cluster: 3-methyl-2-oxobutanoate dehydrogenase;
n=4; Cystobacterineae|Rep: 3-methyl-2-oxobutanoate
dehydrogenase - Anaeromyxobacter sp. Fw109-5
Length = 399
Score = 57.2 bits (132), Expect = 4e-07
Identities = 65/238 (27%), Positives = 95/238 (39%), Gaps = 12/238 (5%)
Frame = +1
Query: 16 GPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAM 195
G TL + L+LY + + R ++ L ++ I GF G+EA +G AAM
Sbjct: 44 GAPDEVTLPDAEVLRLYRLMVLNRSLDERMITLQRQGRI-GFYIGSIGEEATILGSAAAM 102
Query: 196 RDADSVITAYRCHGWTYLMG--LVCWGCSRS*RGAGPVAPGAREVPC-------ICTDAT 348
++D + YR HG + G LV + C AG G R++PC T +
Sbjct: 103 AESDWIFPCYREHGAALMRGMPLVTFLCDLF-GNAGDAMKG-RQMPCHEAWRPGRFTSIS 160
Query: 349 SMVATGLL-VRRSRWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCV 525
S ++T + + W A T G L R +P V
Sbjct: 161 SPISTQISHAVGAAWAARLKGDAMVALTYFGEGGTSAHDFHTG-----LNFAAVRKIPVV 215
Query: 526 FVCENNGYGMGTSVDRSSASTEYYTRG-DY-VPGVWVDGMDVLATREAARFAIEYCNA 693
FVC NNG+ + +R + S + Y + G VDG D+LA A R A E A
Sbjct: 216 FVCRNNGWAISVPRERQTGSETIAQKAIAYGMRGERVDGNDLLAVHAATRRARERAEA 273
>UniRef50_A4VXG8 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex, dehydrogenase (E1) component, eukaryotic type,
alpha subunit; n=40; Streptococcus|Rep:
Pyruvate/2-oxoglutarate dehydrogenase complex,
dehydrogenase (E1) component, eukaryotic type, alpha
subunit - Streptococcus suis (strain 05ZYH33)
Length = 337
Score = 57.2 bits (132), Expect = 4e-07
Identities = 53/228 (23%), Positives = 91/228 (39%), Gaps = 8/228 (3%)
Frame = +1
Query: 34 TLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSV 213
++T E L ++ ++ +R ++ L + ++G H G+EA AVG A + D D +
Sbjct: 18 SITKEQHLDMFLKMQQIRDVDMKLNKLVRRGFVQGMTHFSVGEEAAAVGPIAGLTDEDII 77
Query: 214 ITAYRCHGWTYLMGLVCWGCSRS*RGAGPVAPGAR--EVPCICTDATSMVATGLLVRRSR 387
+ +R HG G+ G G R + + + + G++
Sbjct: 78 FSHHRGHGHVIAKGIDINGMMAELAGKATGTSKGRGGSMHLANVEKGNFGSNGIV--GGG 135
Query: 388 WELEWPSPTSTAPTGSH---XXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMG 558
+ L + + G+ GS S+ +LP +F NN YG+
Sbjct: 136 YALAVGAALTQQYLGTDNIVIAFSGDSATNEGSFHESMNLAAVWNLPVIFFITNNRYGIS 195
Query: 559 TSVDRSSASTEYYTRGDY--VPGVWV-DGMDVLATREAARFAIEYCNA 693
T + S+ Y R +PG +V DG DV+A E + IEY A
Sbjct: 196 TDISYSTKIPHLYQRAAAYGIPGHYVEDGNDVIAVYEKMQEVIEYVRA 243
Score = 56.8 bits (131), Expect = 5e-07
Identities = 25/61 (40%), Positives = 38/61 (62%), Gaps = 2/61 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVAFAHK 416
++ G+ + G+++EL G+ TG S+G+GGSMHL + +G NGIVG L G A +
Sbjct: 88 IAKGIDINGMMAELAGKATGTSKGRGGSMHLANVEKGNFGSNGIVGGGYALAVGAALTQQ 147
Query: 417 Y 419
Y
Sbjct: 148 Y 148
>UniRef50_A0LTQ9 Cluster: Pyruvate dehydrogenase; n=1; Acidothermus
cellulolyticus 11B|Rep: Pyruvate dehydrogenase -
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Length = 342
Score = 56.4 bits (130), Expect = 6e-07
Identities = 29/66 (43%), Positives = 36/66 (54%), Gaps = 2/66 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVAFAHK 416
LS G S+ GV+ EL GR G GKGGSMHL G IVGA +P+ G A++ K
Sbjct: 87 LSRGASMTGVMGELMGRSVGLMAGKGGSMHLTSVEHGMMGSYAIVGAHLPVAVGAAWSAK 146
Query: 417 YRADGE 434
R +
Sbjct: 147 VRGTNQ 152
Score = 56.0 bits (129), Expect = 8e-07
Identities = 61/235 (25%), Positives = 90/235 (38%), Gaps = 8/235 (3%)
Frame = +1
Query: 7 LDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMR 186
L + P +A + + L L+E + LR E + +L+ + +++G HL GQEAVA G
Sbjct: 9 LPERPTFTAEVNGRE-LDLFELMVRLRFFERRAHDLFLQGLVKGTSHLSLGQEAVATGFA 67
Query: 187 AAMRDADSVITAYRCHGWTYLMGLVCWGCSRS*RGAGPVAPGAREVPCICTDATSMVATG 366
AAM D YR H T G G G + T +
Sbjct: 68 AAMEPTDLTFATYRGHAHTLSRGASMTGVMGELMGRSVGLMAGKGGSMHLTSVEHGMMGS 127
Query: 367 LLVRRSRWELEWPSPTSTAPTGSH---XXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCE 537
+ + + + S G++ G+ +L +P VFVCE
Sbjct: 128 YAIVGAHLPVAVGAAWSAKVRGTNQVVVCFFGDGTTNIGAFHEALSLAAVWRVPVVFVCE 187
Query: 538 NNGYGMGTSVDRSSASTEYYTRGDY-----VPGVWVDGMDVLATREAARFAIEYC 687
NN Y TS+ SS + D + V VDG DV A + AR +I C
Sbjct: 188 NNLYMEYTSI--SSVTPVVRPLADRASAYGLSAVVVDGNDVAAVFDVARRSIAEC 240
>UniRef50_A0JUQ5 Cluster: Pyruvate dehydrogenase; n=4;
Actinobacteria (class)|Rep: Pyruvate dehydrogenase -
Arthrobacter sp. (strain FB24)
Length = 392
Score = 56.4 bits (130), Expect = 6e-07
Identities = 57/220 (25%), Positives = 92/220 (41%), Gaps = 5/220 (2%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 216
++ E LYE + ++RRI+T + L ++ + G GQEA +G ++RD D V
Sbjct: 53 VSDEQLGSLYEDMVVIRRIDTEATALQRQGEL-GLWPPLLGQEASQIGSARSLRDDDFVF 111
Query: 217 TAYRCHGWTYLMGLVCWGCSRS*RGAGPVAPGAREV----PCICTDATSMVATGLLVRRS 384
++YR +G Y G+ + RG + P I A ++ ATG +
Sbjct: 112 SSYRENGVAYCRGVDLADILKVWRGNASAGWDPYTINMATPQIIIGAQTLHATGYAM--- 168
Query: 385 RWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMGTS 564
++ S A T G ++ + P +F C+NN + +
Sbjct: 169 --GIQNDGADSVAIT-----YFGDGATSEGDVNEAMVFAASFQSPVIFFCQNNHWAISEP 221
Query: 565 VD-RSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIE 681
V +S G +PG+ VDG DVLA A R A+E
Sbjct: 222 VRLQSHIRIADRAAGFGIPGIRVDGNDVLAVMAATREALE 261
>UniRef50_A0UXT3 Cluster: Pyruvate dehydrogenase; n=1; Clostridium
cellulolyticum H10|Rep: Pyruvate dehydrogenase -
Clostridium cellulolyticum H10
Length = 321
Score = 56.0 bits (129), Expect = 8e-07
Identities = 26/60 (43%), Positives = 37/60 (61%), Gaps = 2/60 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVAFAHK 416
++ G + +++EL R+TGC+ G+GGSMHL R +G IVG +PLG G A A K
Sbjct: 70 IAKGGDIKQMIAELYLRKTGCTSGRGGSMHLMAADRGIFGSTAIVGGSLPLGTGTALASK 129
Score = 46.8 bits (106), Expect = 5e-04
Identities = 28/74 (37%), Positives = 36/74 (48%), Gaps = 2/74 (2%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGT-SVDRSSASTEYYTRGDY-VPGVWVDGMDV 645
G+ SL + LP ++VCENN Y + + R S Y Y +PG +DG DV
Sbjct: 149 GTFHESLNFASLKKLPILYVCENNFYAINSRQAQRQSGDNIYKMAQVYGIPGYQIDGNDV 208
Query: 646 LATREAARFAIEYC 687
L E A AIE C
Sbjct: 209 LKVSEYAEKAIERC 222
Score = 35.9 bits (79), Expect = 0.94
Identities = 19/66 (28%), Positives = 33/66 (50%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 216
+ +E ++LY + +R +E YK ++ HL GQEA+A G+ +R D +
Sbjct: 1 MENERFIELYRVMQTIRIVERKIEEEYKNDEMKTPIHLSIGQEAIAAGVCINLRKDDYLF 60
Query: 217 TAYRCH 234
+R H
Sbjct: 61 GTHRSH 66
Score = 34.7 bits (76), Expect = 2.2
Identities = 14/42 (33%), Positives = 25/42 (59%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
P+G+ + L ++ + VT +GDGAA++G E+ N + L
Sbjct: 119 PLGTGTALASKIQKNDRVTAVFFGDGAADEGTFHESLNFASL 160
>UniRef50_A7BPK6 Cluster: Pyruvate dehydrogenase; n=1; Beggiatoa sp.
PS|Rep: Pyruvate dehydrogenase - Beggiatoa sp. PS
Length = 331
Score = 55.6 bits (128), Expect = 1e-06
Identities = 54/216 (25%), Positives = 82/216 (37%), Gaps = 5/216 (2%)
Frame = +1
Query: 46 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAY 225
E+ L Y L ++RR+E A Y E+ +R HL GQEAVAVG+ ++ +D + +++
Sbjct: 14 EELLTFYRSLLLIRRVEEAIAERYTEQEMRCPTHLCIGQEAVAVGVCKMLQQSDGIFSSH 73
Query: 226 RCHGWTYLMGLVCWGCSRS*RGAGPVAPGAREVPCICTDATSMVATGLLVRRSRWELEWP 405
R H G G G R D + + S +
Sbjct: 74 RAHSHYLAKGGDLKAMIAELYGKSTGCCGGRGGSMHLIDLAAGFIGATPIVGSTIPIAVG 133
Query: 406 SPTSTAPTGSH---XXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVD-- 570
S G + + G S+ LP +FVCENNGY + T ++
Sbjct: 134 HAWSAYLRGKNRVTVVFFGDGCFEEGVMHESMNFASLYKLPIIFVCENNGYSVYTRLEAR 193
Query: 571 RSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAI 678
+ + + + DG DVL AR AI
Sbjct: 194 QPERTIRGIAQSHGLETYHGDGNDVLNVTALAREAI 229
Score = 48.8 bits (111), Expect = 1e-04
Identities = 23/58 (39%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFA 410
L+ G + +++EL G+ TGC G+GGSMHL F G IVG+ +P+ G A++
Sbjct: 80 LAKGGDLKAMIAELYGKSTGCCGGRGGSMHLIDLAAGFIGATPIVGSTIPIAVGHAWS 137
>UniRef50_Q9HN77 Cluster: Pyruvate dehydrogenase alpha subunit; n=8;
Halobacteriaceae|Rep: Pyruvate dehydrogenase alpha
subunit - Halobacterium salinarium (Halobacterium
halobium)
Length = 419
Score = 55.2 bits (127), Expect = 1e-06
Identities = 55/221 (24%), Positives = 87/221 (39%), Gaps = 6/221 (2%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 216
LT ++ +++Y + + RR + + +L ++ I + L SGQE + A+ D D ++
Sbjct: 79 LTDDELVEMYRYMKLARRFDERAVSLQRQGRIGTYPPL-SGQEGAQIASAMALADDDWIV 137
Query: 217 TAYRCHGWTYLMGLVCWGCSRS*RG--AGPVAPGAREVPCICTDATSMV--ATGLLVRRS 384
+YR HG + + GL G G P + + S + ATG
Sbjct: 138 PSYREHGASLVRGLPLKDTLLYWMGDERGNAIPAEENIFTVAVPIASQIPHATG------ 191
Query: 385 RWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMGTS 564
+ W S + G L D P VF C NN + +
Sbjct: 192 ---MGWASQLKDESDTAFMCYFGDGATSEGDFHEGLNFAGVYDTPNVFFCNNNQWAISVP 248
Query: 565 VDRSSAS-TEYYTRGDY-VPGVWVDGMDVLATREAARFAIE 681
++ +A+ T Y GV VDGMD LA + A AIE
Sbjct: 249 REQQTATDTLAQKAAAYGFEGVQVDGMDPLAVYQVAHDAIE 289
>UniRef50_Q7N3C2 Cluster: Similar to 3-methyl-2-oxobutanoate
dehydrogenase; n=1; Photorhabdus luminescens subsp.
laumondii|Rep: Similar to 3-methyl-2-oxobutanoate
dehydrogenase - Photorhabdus luminescens subsp.
laumondii
Length = 650
Score = 54.4 bits (125), Expect = 3e-06
Identities = 31/73 (42%), Positives = 40/73 (54%)
Frame = +3
Query: 210 SNHRVSLSRMDLSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPL 389
SNHR LS V G+++E+ G+ TG G+GGS HL F+ NGI G +P+
Sbjct: 57 SNHRCH--GHFLSRTGDVTGLIAEVMGKETGVCGGRGGSQHLCKEGFF-SNGIQGGILPV 113
Query: 390 GAGVAFAHKYRAD 428
G AFA K R D
Sbjct: 114 ATGAAFAKKLRHD 126
>UniRef50_Q28MR4 Cluster: Dehydrogenase E1 component; n=8;
Bacteria|Rep: Dehydrogenase E1 component - Jannaschia
sp. (strain CCS1)
Length = 675
Score = 54.4 bits (125), Expect = 3e-06
Identities = 28/65 (43%), Positives = 37/65 (56%), Gaps = 2/65 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHK 416
++ G + + +EL GR TG G GGSMH+ + R G NGIVGA + LG G A A +
Sbjct: 87 IAKGADLGRMFAELMGRETGYCAGLGGSMHIADFDRGILGANGIVGAGIGLGTGAALAEQ 146
Query: 417 YRADG 431
A G
Sbjct: 147 LDATG 151
Score = 52.8 bits (121), Expect = 8e-06
Identities = 27/78 (34%), Positives = 41/78 (52%)
Frame = +1
Query: 22 ATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRD 201
AT L +D + + +RR ET + L+ + +I+G H GQEA+A G A +
Sbjct: 13 ATPNGLAPKDLRAALKMMLRIRRFETRAKELFLQGVIKGTAHSSVGQEAIAAGACAVLEP 72
Query: 202 ADSVITAYRCHGWTYLMG 255
AD ++T +R HG T G
Sbjct: 73 ADFILTHHRGHGHTIAKG 90
Score = 39.5 bits (88), Expect = 0.076
Identities = 21/52 (40%), Positives = 26/52 (50%), Gaps = 2/52 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREA 663
LP +F CENN YG+ T +A RGD VP +DG D+ A A
Sbjct: 180 LPLIFFCENNQYGLTTPTTAVTAGPSIAARGDAYGVPNEQIDGNDLPAVHMA 231
>UniRef50_Q13GQ3 Cluster: Putative 2-oxo acid dehydrogenase alpha
subunit; n=1; Burkholderia xenovorans LB400|Rep:
Putative 2-oxo acid dehydrogenase alpha subunit -
Burkholderia xenovorans (strain LB400)
Length = 334
Score = 54.0 bits (124), Expect = 3e-06
Identities = 27/62 (43%), Positives = 35/62 (56%), Gaps = 2/62 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHK 416
L+ G+ V G E+ GR G +G+GGSMH+ G NGIVGA +P+ G A AH
Sbjct: 83 LARGIDVGGFFKEIMGRVGGLCKGRGGSMHVADLALGVLGANGIVGAGIPIALGSAVAHH 142
Query: 417 YR 422
R
Sbjct: 143 VR 144
Score = 52.8 bits (121), Expect = 8e-06
Identities = 49/211 (23%), Positives = 85/211 (40%), Gaps = 4/211 (1%)
Frame = +1
Query: 55 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 234
+ +Y + ++R +E + L+ + + GF HL GQEAV+ G+ + + D++ T +R H
Sbjct: 20 IDIYRTMVLVREVELSLSRLFADSEVPGFIHLSLGQEAVSAGVASVLEVQDTLATTHRGH 79
Query: 235 GWTYLMGLVCWGCSRS*RG-AGPVAPGAREVPCICTDATSMV-ATGLLVRRSRWELEWPS 408
G G+ G + G G + G + A ++ A G++ L
Sbjct: 80 GHVLARGIDVGGFFKEIMGRVGGLCKGRGGSMHVADLALGVLGANGIVGAGIPIALGSAV 139
Query: 409 PTSTAPT-GSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSAS 585
T G G ++ P + VCENNG+ + +R A+
Sbjct: 140 AHHVRKTRGVAVAFFGDGAMAEGVLHETMNMAALWKAPLLLVCENNGWSEFSPTERQFAA 199
Query: 586 TEYYTRGDY-VPGVWVDGMDVLATREAARFA 675
G + + VDG D +A EA+ A
Sbjct: 200 RLEALAGAFGIAYKRVDGDDAVAVSEASGIA 230
Score = 35.9 bits (79), Expect = 0.94
Identities = 17/42 (40%), Positives = 23/42 (54%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
P+ S + V + RGV A +GDGA +G L E NM+ L
Sbjct: 132 PIALGSAVAHHVRKTRGVAVAFFGDGAMAEGVLHETMNMAAL 173
>UniRef50_Q53610 Cluster: Branched-chain alpha-keto acid
dehydrogenase E1-alpha subunit; n=16;
Actinomycetales|Rep: Branched-chain alpha-keto acid
dehydrogenase E1-alpha subunit - Streptomyces
avermitilis
Length = 406
Score = 53.2 bits (122), Expect = 6e-06
Identities = 56/222 (25%), Positives = 88/222 (39%), Gaps = 5/222 (2%)
Frame = +1
Query: 31 ATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADS 210
A +T E+ LY + + RR + + +L ++ + G GQEA +G A RD D
Sbjct: 63 ADITPEELRGLYRDMVLSRRFDAEATSLQRQGEL-GLWASMLGQEAAQIGSGRATRDDDY 121
Query: 211 VITAYRCHGWTYLMGLVCWGCSRS*RGA--GPVAPGAR--EVPCICTDATSMVATGLLVR 378
V YR HG + G+ RG G P + + I + ++ ATG +
Sbjct: 122 VFPTYREHGVAWCRGVDPTNLLGMFRGVNNGGWDPNSNNFHLYTIVIGSQTLHATGYAMG 181
Query: 379 RSRWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMG 558
++ + A G G S + P VF C+NN + +
Sbjct: 182 IAK---DGADSAVIAYFGD-------GASSQGDVAESFTFSAVYNAPVVFFCQNNQWAIS 231
Query: 559 TSVDRSSASTEYYTRGDY-VPGVWVDGMDVLATREAARFAIE 681
++ + Y Y PGV VDG DVLA ++A+E
Sbjct: 232 EPTEKQTRVPLYQRAQGYGFPGVRVDGNDVLACLAVTKWALE 273
>UniRef50_Q1NYU1 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=1; Candidatus Sulcia muelleri str. Hc
(Homalodisca coagulata)|Rep: Pyruvate dehydrogenase E1
component alpha subunit - Candidatus Sulcia muelleri
str. Hc (Homalodisca coagulata)
Length = 167
Score = 53.2 bits (122), Expect = 6e-06
Identities = 31/58 (53%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRG-DY-VPGVWVDGMDVLATREAARFAI 678
+LP VF+CENN Y MGTSV RSS + Y G Y +P VDGMD L E A AI
Sbjct: 1 ELPVVFICENNRYAMGTSVKRSSNIKDIYKIGFSYKMPSFCVDGMDPLKIYEHAYNAI 58
>UniRef50_Q319T4 Cluster: Pyruvate dehydrogenase; n=1;
Prochlorococcus marinus str. MIT 9312|Rep: Pyruvate
dehydrogenase - Prochlorococcus marinus (strain MIT
9312)
Length = 347
Score = 52.8 bits (121), Expect = 8e-06
Identities = 27/64 (42%), Positives = 37/64 (57%), Gaps = 2/64 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVAFAHK 416
LS G+ + SE+ + +G S+G GGSMHL+G + F G IVG VPL G A A K
Sbjct: 92 LSLGIDLKSFFSEILAKSSGISKGMGGSMHLFGGSVGFCGSVPIVGGTVPLAVGTALASK 151
Query: 417 YRAD 428
+ +
Sbjct: 152 LKEE 155
Score = 36.7 bits (81), Expect = 0.54
Identities = 18/71 (25%), Positives = 36/71 (50%)
Frame = +1
Query: 46 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAY 225
++ L++ ++ ++R E + ++ G HL GQEA+ VG+ + + D V A+
Sbjct: 26 DELLEMLSKMILIRNAEYKIAKGREFGLVGGPVHLGVGQEAIPVGISQYLNNQDKVFGAH 85
Query: 226 RCHGWTYLMGL 258
R H +G+
Sbjct: 86 RSHSHILSLGI 96
>UniRef50_A4AFX0 Cluster: Acetoin dehydrogenase (TPP-dependent)
alpha chain; n=1; marine actinobacterium PHSC20C1|Rep:
Acetoin dehydrogenase (TPP-dependent) alpha chain -
marine actinobacterium PHSC20C1
Length = 327
Score = 52.8 bits (121), Expect = 8e-06
Identities = 26/69 (37%), Positives = 38/69 (55%)
Frame = +1
Query: 49 DALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYR 228
DAL+L + +R E L+ + ++RG HL GQEAV VG+ +A+ D++ YR
Sbjct: 17 DALELLRSMYEIRFFEDEIMGLFSQNLVRGSTHLCQGQEAVTVGVCSALSPGDTMTCTYR 76
Query: 229 CHGWTYLMG 255
HG MG
Sbjct: 77 GHGAVLAMG 85
Score = 45.2 bits (102), Expect = 0.002
Identities = 26/66 (39%), Positives = 30/66 (45%), Gaps = 2/66 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHK 416
L+ G + E+ GR G GKGGSMHL G N IVG +P G A A
Sbjct: 82 LAMGAPLDRAFGEILGRAGGLCGGKGGSMHLADVSVGALGSNAIVGGHLPTTVGAALAAS 141
Query: 417 YRADGE 434
YR E
Sbjct: 142 YRGTSE 147
Score = 44.8 bits (101), Expect = 0.002
Identities = 25/62 (40%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRG-DY-VPGVWVDGMDVLATREAARFAIEYC 687
LP +FV ENN YG +++ ++ R Y +PGV+VDG DV+A R A + A+E
Sbjct: 175 LPAIFVIENNQYGEYSTLASTTPIERLSDRAASYGMPGVFVDGNDVIAMRSATKTAVERA 234
Query: 688 NA 693
A
Sbjct: 235 RA 236
>UniRef50_A4XF89 Cluster: Dehydrogenase, E1 component; n=1;
Novosphingobium aromaticivorans DSM 12444|Rep:
Dehydrogenase, E1 component - Novosphingobium
aromaticivorans (strain DSM 12444)
Length = 315
Score = 52.4 bits (120), Expect = 1e-05
Identities = 55/212 (25%), Positives = 86/212 (40%), Gaps = 7/212 (3%)
Frame = +1
Query: 61 LYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCHGW 240
++ +L + R +ET +E+ G+ H GQEA +G AA+ D V R W
Sbjct: 12 MFHKLAVSRAVETLMLRHTREERFSGWWHPGEGQEAAPIGATAALEADDYVWYQGRGCAW 71
Query: 241 TYLMGLVCWGCSRS*RGAGPVAPGAR--EVPCICTDATSMVATGLLVRRSRWELEWPSPT 414
G+ G A G + VP + ++ G + S + L S
Sbjct: 72 AIGKGMDPLPILGDLLGKTNGATGGKGGGVPHWADYSLGIMGEGATL-GSVYPLAAGSAL 130
Query: 415 ST--APTGSHXXXXXXXXXQPGSTL-RSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSAS 585
++ G T ++ H LP ++ CENNG +GT ++ SA+
Sbjct: 131 ASKIRKDGRVSLANFGDGTASRGTFHETMMHAAAWKLPLIYFCENNGLLVGTRTEQVSAT 190
Query: 586 TEY--YTRGDYVPGVWVDGMDVLATREAARFA 675
+ +G +PGV VDG D +A EA R A
Sbjct: 191 ADIANLAKGYGIPGVIVDGQDAVAVWEATREA 222
>UniRef50_A0HHH5 Cluster: Dehydrogenase, E1 component; n=2;
Bacteria|Rep: Dehydrogenase, E1 component - Comamonas
testosteroni KF-1
Length = 327
Score = 52.4 bits (120), Expect = 1e-05
Identities = 27/69 (39%), Positives = 38/69 (55%)
Frame = +1
Query: 52 ALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRC 231
A +L EQ+ +R +E +L K I+G HL GQEA+ G AA + D V + YR
Sbjct: 16 AKELLEQMIRIRLLEEKIADLRKSGEIQGSVHLCIGQEAIYSGSCAARQPGDRVFSTYRG 75
Query: 232 HGWTYLMGL 258
HGW + G+
Sbjct: 76 HGWAHACGV 84
Score = 47.6 bits (108), Expect = 3e-04
Identities = 25/62 (40%), Positives = 31/62 (50%), Gaps = 2/62 (3%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVAFAHKYRA 425
GV +L+EL R TG G+GGS + F+G N IVGA P+ G A A
Sbjct: 83 GVPAEAILAELLARETGVCAGRGGSAYFSAPEWGFFGENSIVGAGAPIACGAALASTMAK 142
Query: 426 DG 431
DG
Sbjct: 143 DG 144
Score = 33.9 bits (74), Expect = 3.8
Identities = 17/51 (33%), Positives = 26/51 (50%), Gaps = 2/51 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATRE 660
LP +F+CENN Y T + + + R + GV +DG D+L R+
Sbjct: 173 LPVIFLCENNTYAELTPIADTVRDAALFKRARAFGMDGVRIDGNDILGVRQ 223
>UniRef50_Q97CK0 Cluster: 2-oxoisovalerate dehydrogenase alpha
subunit; n=2; Thermoplasma|Rep: 2-oxoisovalerate
dehydrogenase alpha subunit - Thermoplasma volcanium
Length = 337
Score = 52.4 bits (120), Expect = 1e-05
Identities = 25/62 (40%), Positives = 37/62 (59%), Gaps = 1/62 (1%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY-VPGVWVDGMDVLATREAARFAIEYC 687
DLP VF+CENNG+ + V+R + + Y Y + GV+VDG D + T A + A+EY
Sbjct: 168 DLPVVFLCENNGWAISFPVERQTKAEIYKKAEAYGMKGVYVDGNDFIKTYNAVKEAVEYA 227
Query: 688 NA 693
+
Sbjct: 228 RS 229
>UniRef50_Q6A611 Cluster: Pyruvate dehydrogenase E1 component, alpha
subunit; n=1; Propionibacterium acnes|Rep: Pyruvate
dehydrogenase E1 component, alpha subunit -
Propionibacterium acnes
Length = 381
Score = 52.0 bits (119), Expect = 1e-05
Identities = 60/237 (25%), Positives = 88/237 (37%), Gaps = 7/237 (2%)
Frame = +1
Query: 4 KLDQGPATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGM 183
+L P L +D +K E + + RR++ + L + + G GQEA G
Sbjct: 40 RLTTHPDFPVDLVDDDLVKALEMMVMTRRLDVEATALQRHGEL-GLWPPLLGQEATQAGA 98
Query: 184 RAAMRDADSVITAYRCHGWTYLMG------LVCWGCSRS*RGAGPVAPGAREVPCICTDA 345
A+R+ D V YR G + MG L W S G VA P +
Sbjct: 99 WLALREGDQVFPTYREQGLAHAMGVSLADILGAWD-GTSHCGWDTVATHFSAYPVMIGSG 157
Query: 346 TSMVATGLLVRRSRWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCV 525
T + A G + R P + G T + + + P V
Sbjct: 158 T-LHAVGYAMGVQRDVEAGGGPAAV------LDFHGDGAMSEGDTNEAYVFAASMNAPVV 210
Query: 526 FVCENNGYGMG-TSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEYCNA 693
FVC NN + + + +S S G +P V VDG DV+A R A+EY +
Sbjct: 211 FVCVNNQWAISEPTTVQSPTSLFRRATGFGIPAVQVDGNDVIAMMAVLRSALEYARS 267
>UniRef50_Q67SE7 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=2; Bacilli|Rep: Pyruvate dehydrogenase E1 alpha
subunit - Symbiobacterium thermophilum
Length = 368
Score = 52.0 bits (119), Expect = 1e-05
Identities = 63/220 (28%), Positives = 87/220 (39%), Gaps = 7/220 (3%)
Frame = +1
Query: 43 SEDALK-LYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMR-DADSVI 216
S D LK +Y ++ LR + NL ++ + F +SGQEA VG +R D D +
Sbjct: 35 SVDQLKDVYRKMVYLRVFDQRCLNLQRQGRMGTFAP-FSGQEASQVGSAYLLRPDRDWIF 93
Query: 217 TAYRCHGWTYLMGLVCWGCSRS*RG--AGPVAP-GAREVPCICTDATSMVATGLLVRRSR 387
YR HG ++MG+ R G G AP G P AT ++ R
Sbjct: 94 PTYRDHGAMHVMGVPLVNILRYFMGDEQGSHAPQGVNAFPISIPIATQLLHAVGAAWAGR 153
Query: 388 WELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMGTSV 567
+ E A G PG +L ++P +F +NN Y + T
Sbjct: 154 IKGEDTVAVGYAGDGG---------TSPGDFHEALNFAAVFNVPVIFFIQNNRYAISTPN 204
Query: 568 DRSSASTEYYTR--GDYVPGVWVDGMDVLATREAARFAIE 681
R + R G + GV VDG DVLA AIE
Sbjct: 205 SRQFKTPTIAQRALGYDIAGVRVDGQDVLAVLAVMHEAIE 244
>UniRef50_Q1ARM0 Cluster: Pyruvate dehydrogenase; n=3; Bacteria|Rep:
Pyruvate dehydrogenase - Rubrobacter xylanophilus
(strain DSM 9941 / NBRC 16129)
Length = 332
Score = 52.0 bits (119), Expect = 1e-05
Identities = 26/73 (35%), Positives = 39/73 (53%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 216
L E + + + +RR E L+K + GF HLY G+EAVAVG +A+R+ D +
Sbjct: 2 LGEEKLVGMLRLMLRIRRFEEKLAELFKRGKLPGFVHLYIGEEAVAVGACSALREDDRIT 61
Query: 217 TAYRCHGWTYLMG 255
+ +R HG G
Sbjct: 62 STHRGHGHVIAKG 74
Score = 49.2 bits (112), Expect = 9e-05
Identities = 23/60 (38%), Positives = 34/60 (56%), Gaps = 2/60 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHK 416
++ G V +++EL G+ G RGKGGSMH + G NGIVG +P+ G A+ +
Sbjct: 71 IAKGADVSRMMAELLGKEAGYCRGKGGSMHTVDFSLGIMGTNGIVGGGIPIAVGSAWGDR 130
Score = 41.1 bits (92), Expect = 0.025
Identities = 23/57 (40%), Positives = 32/57 (56%), Gaps = 2/57 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRG--DYVPGVWVDGMDVLATREAARFAI 678
LP +F+CENNGY T ++ +A RG +P V VDG DV++ EA A+
Sbjct: 164 LPVIFLCENNGYTEWTPTEKLTAG-RISDRGVPFGIPSVQVDGNDVISVHEAVSEAV 219
Score = 32.7 bits (71), Expect = 8.8
Identities = 13/28 (46%), Positives = 19/28 (67%)
Frame = +2
Query: 425 RRGVTFALYGDGAANQGQLFEAYNMSKL 508
R VT + +GDGA+NQG FE N++ +
Sbjct: 134 RDTVTVSFFGDGASNQGVFFEGMNLAAI 161
>UniRef50_Q5SJR9 Cluster: Pyruvate dehydrogenase (Lipoamide) (EC
1.2.4.1) E1-alpha chain; n=2; Thermus thermophilus|Rep:
Pyruvate dehydrogenase (Lipoamide) (EC 1.2.4.1) E1-alpha
chain - Thermus thermophilus (strain HB8 / ATCC 27634 /
DSM 579)
Length = 346
Score = 51.6 bits (118), Expect = 2e-05
Identities = 66/223 (29%), Positives = 90/223 (40%), Gaps = 8/223 (3%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 216
L E+AL+LY + R + + L ++ + G + GQEA VG+ A+ + D V+
Sbjct: 16 LAEEEALRLYRAMRRARFFDEKALTLQRQGRL-GVYAPFMGQEAAQVGVALALEERDWVV 74
Query: 217 TAYRCHGWTYLMGLVCWGCSRS*RG--AGPVAP-GAREVPCICTDATSMV-ATGL-LVRR 381
+YR GL R AG P G R V AT + A GL L R
Sbjct: 75 PSYRESAMLLAKGLPIHTLILYWRAHPAGWRFPEGVRAVNPYIPIATQIPQAVGLALAGR 134
Query: 382 SRWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMGT 561
R E +W TS G+ G L P VF+ +NNGY +
Sbjct: 135 YRGE-DWVVATSIGDGGT----------SEGDFHEGLNFAAVFGAPVVFLVQNNGYAISV 183
Query: 562 SVDRSSASTEYYTR---GDYVPGVWVDGMDVLATREAARFAIE 681
R +Y R G +PGV VDG D A A+ A+E
Sbjct: 184 PKSRQM-KVDYVARRAEGYGMPGVVVDGNDAFAVYLEAKKAVE 225
>UniRef50_Q3DZ88 Cluster: Dehydrogenase, E1 component; n=1;
Chloroflexus aurantiacus J-10-fl|Rep: Dehydrogenase, E1
component - Chloroflexus aurantiacus J-10-fl
Length = 334
Score = 51.6 bits (118), Expect = 2e-05
Identities = 26/66 (39%), Positives = 37/66 (56%), Gaps = 2/66 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYG--RNFYGGNGIVGAQVPLGAGVAFAHK 416
L+ G V +++E G+ TG RG+GGSMH+ N G NGIVG +P+ GV + K
Sbjct: 91 LAWGSDVRLMMAEFLGKETGYCRGRGGSMHIANVEMNNLGANGIVGGGIPISVGVGLSIK 150
Query: 417 YRADGE 434
R +
Sbjct: 151 KRRSSQ 156
Score = 46.8 bits (106), Expect = 5e-04
Identities = 21/56 (37%), Positives = 33/56 (58%)
Frame = +1
Query: 70 QLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCHG 237
++ I+R E + L+ ++ G HL GQEAVA+G AAM+ D ++ +R HG
Sbjct: 33 RMQIIRAFEEKAEELFARGLVHGTMHLSIGQEAVAIGASAAMKPGDYLLNHHRGHG 88
Score = 41.1 bits (92), Expect = 0.025
Identities = 21/58 (36%), Positives = 30/58 (51%), Gaps = 2/58 (3%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRGD--YVPGVWVDGMDVLATREAARFAI 678
+LP V++CENN Y M + ++ R + G+ VDG D LA EA R A+
Sbjct: 183 NLPVVYLCENNQYAMSMPIQKACRLNHLSQRAAAYAIAGITVDGNDALAVYEAVRQAV 240
>UniRef50_A6UDY5 Cluster: Dehydrogenase E1 component; n=2;
Alphaproteobacteria|Rep: Dehydrogenase E1 component -
Sinorhizobium medicae WSM419
Length = 342
Score = 51.6 bits (118), Expect = 2e-05
Identities = 28/78 (35%), Positives = 43/78 (55%), Gaps = 2/78 (2%)
Frame = +1
Query: 466 QPGSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGM 639
Q G S+ +LP +FVC NN YGMGT +D+++ +T + R + G VDG+
Sbjct: 151 QQGILYESMNMASLWNLPVLFVCINNQYGMGTRIDQATRNTAFDQRAKAFGLNGAVVDGL 210
Query: 640 DVLATREAARFAIEYCNA 693
DV + AAR+ ++ A
Sbjct: 211 DVEEVQAAARWLVDEARA 228
Score = 46.4 bits (105), Expect = 7e-04
Identities = 24/61 (39%), Positives = 35/61 (57%), Gaps = 4/61 (6%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVP--LGAGVAFA 410
L+ G +++E+ G+ TG RGKGGSMH+ G N IVG +P +GAG++
Sbjct: 74 LARGADPKRMMAEIGGKETGYCRGKGGSMHIADMALGHLGANAIVGGGIPAVIGAGLSSR 133
Query: 411 H 413
H
Sbjct: 134 H 134
Score = 37.9 bits (84), Expect = 0.23
Identities = 22/62 (35%), Positives = 32/62 (51%), Gaps = 1/62 (1%)
Frame = +1
Query: 55 LKLYEQLTILRRIETASGNLYKEKIIRG-FCHLYSGQEAVAVGMRAAMRDADSVITAYRC 231
L+LY + +R E G L+ G HL G+E+ A G+ AAM+ D+ T +R
Sbjct: 10 LELYRTMRRIRTFEERVGELFVRGQSAGSMLHLSIGEESSAAGVCAAMKPQDTFTTHHRG 69
Query: 232 HG 237
HG
Sbjct: 70 HG 71
Score = 33.9 bits (74), Expect = 3.8
Identities = 15/37 (40%), Positives = 24/37 (64%)
Frame = +2
Query: 398 SGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
+GL + ++ V+ A +GDGA QG L+E+ NM+ L
Sbjct: 128 AGLSSRHLKQDSVSIAFFGDGAMQQGILYESMNMASL 164
>UniRef50_A5V557 Cluster: Pyruvate dehydrogenase; n=1; Sphingomonas
wittichii RW1|Rep: Pyruvate dehydrogenase - Sphingomonas
wittichii RW1
Length = 331
Score = 51.6 bits (118), Expect = 2e-05
Identities = 27/71 (38%), Positives = 41/71 (57%), Gaps = 2/71 (2%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHK 416
++ G + +++EL G+ TG +GKGGSMHL + G IVG+ VP+ AG A K
Sbjct: 73 IAKGAKLRPLMAELLGKATGICKGKGGSMHLSDFSVGSLGETSIVGSGVPVAAGAALGSK 132
Query: 417 YRADGESRSLC 449
+ +G +LC
Sbjct: 133 LQGNGRV-ALC 142
Score = 43.6 bits (98), Expect = 0.005
Identities = 20/65 (30%), Positives = 37/65 (56%)
Frame = +1
Query: 43 SEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITA 222
++ +L+ Y ++ +R+ E + ++ + I G H Y+GQEA VG A+ D D ++
Sbjct: 6 NDRSLEKYRRMQRIRQFEDLAEAIHAQGEIPGSLHTYAGQEASGVGACMALDDTDYMVGT 65
Query: 223 YRCHG 237
+R HG
Sbjct: 66 HRSHG 70
Score = 39.5 bits (88), Expect = 0.076
Identities = 21/57 (36%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAI 678
LP +FVCENNGY + T + + R +P + VDG DV A A A+
Sbjct: 166 LPAIFVCENNGYAVSTPASATVPVKDVAERARAYGMPSIIVDGQDVDAVEAAVAEAV 222
>UniRef50_A3CMZ3 Cluster: Pyruvate dehydrogenase, TPP-dependent E1
component alpha-subunit, putative; n=22; Bacteria|Rep:
Pyruvate dehydrogenase, TPP-dependent E1 component
alpha-subunit, putative - Streptococcus sanguinis
(strain SK36)
Length = 357
Score = 50.8 bits (116), Expect = 3e-05
Identities = 23/61 (37%), Positives = 36/61 (59%), Gaps = 2/61 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHK 416
++ G + G+++E+ G+ TG +GKGGSMH+ + G NG+VG L G A +K
Sbjct: 108 VAKGGDLKGMMAEIFGKETGLGKGKGGSMHIADLDKGILGANGMVGGGFGLATGAAMRNK 167
Query: 417 Y 419
Y
Sbjct: 168 Y 168
Score = 48.8 bits (111), Expect = 1e-04
Identities = 22/67 (32%), Positives = 38/67 (56%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 216
++ E A +Y+ + +R E + + I GF HLY+G+EA+A G+ A + D D +
Sbjct: 39 VSKEKAKTMYKTMWDIRNFEENTRRFFAAGQIPGFVHLYAGEEAIATGVCANLTDKDYIT 98
Query: 217 TAYRCHG 237
+ +R HG
Sbjct: 99 STHRGHG 105
Score = 35.5 bits (78), Expect = 1.2
Identities = 23/58 (39%), Positives = 31/58 (53%), Gaps = 2/58 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAIE 681
LP +FV ENN + T SSAS R +PGV V+G D+ A + A+ A+E
Sbjct: 201 LPVIFVNENNLFAESTPQWYSSASGTIAERAAAYNMPGVRVNGKDLFAVYQVAKEAVE 258
>UniRef50_Q83FF2 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=2; Tropheryma whipplei|Rep: Pyruvate
dehydrogenase E1 component alpha subunit - Tropheryma
whipplei (strain Twist) (Whipple's bacillus)
Length = 370
Score = 50.4 bits (115), Expect = 4e-05
Identities = 51/219 (23%), Positives = 87/219 (39%), Gaps = 7/219 (3%)
Frame = +1
Query: 34 TLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSV 213
+L ED + Y + ++R+I+ + L + + + +Y GQEA +G A + D +
Sbjct: 33 SLDVEDIQRFYRDIILVRQIDHEAALLQRRGELALWPPVY-GQEASQIGATYACSENDMI 91
Query: 214 ITAYRCHGWTYLMGLVCWGCSRS*RGAGPVAPGAREVPC----ICTDATSMVATGLLVRR 381
+YR H + G+ ++ RGA R+ +C A + +TG +
Sbjct: 92 FPSYRDHAVMHARGIDLVHIAKLFRGASNNDWDVRQHKVWGYTLCIGAQVLHSTGYAIGI 151
Query: 382 S-RWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMG 558
++ S P Q G S+ P VF+ +NN Y +
Sbjct: 152 VLERQMSCTDDNSGYPEAVMVWFGDGASSQ-GDVSESMVFAARYQTPQVFMLQNNQYAIS 210
Query: 559 TSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAAR 669
SA+ Y RG +PG+ +DG DV+A R
Sbjct: 211 VPASVPSAACPLYKRGYGFGIPGIRIDGNDVIAAYAVVR 249
>UniRef50_Q0ET31 Cluster: Dehydrogenase, E1 component; n=1;
Thermoanaerobacter ethanolicus X514|Rep: Dehydrogenase,
E1 component - Thermoanaerobacter ethanolicus X514
Length = 262
Score = 50.4 bits (115), Expect = 4e-05
Identities = 24/63 (38%), Positives = 37/63 (58%), Gaps = 1/63 (1%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRN-FYGGNGIVGAQVPLGAGVAFAHKY 419
++ GV + + +E+ G+ TG RGKGG MHL+ + + +GIVGA +P G A K
Sbjct: 82 IAKGVDLKRMTAEIFGKVTGLGRGKGGHMHLFDPDVHFSCSGIVGASIPQAVGAALTFKM 141
Query: 420 RAD 428
R +
Sbjct: 142 RKE 144
Score = 33.5 bits (73), Expect = 5.0
Identities = 21/84 (25%), Positives = 39/84 (46%), Gaps = 10/84 (11%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKI----------IRGFCHLYSGQEAVAVGMR 186
+ E +++Y ++ +R E Y+E + G HL +GQE VAVG+
Sbjct: 3 IPKETLIRMYLEMVTIRLYEETMAEAYQEGKYPVFNIASGPVPGEMHLAAGQEPVAVGVC 62
Query: 187 AAMRDADSVITAYRCHGWTYLMGL 258
++ D+V+ +R H + G+
Sbjct: 63 MHLKKEDAVVGTHRPHHFAIAKGV 86
>UniRef50_Q9RYC1 Cluster: 2-oxo acid dehydrogenase, E1 component,
alpha subunit; n=2; Deinococcus|Rep: 2-oxo acid
dehydrogenase, E1 component, alpha subunit - Deinococcus
radiodurans
Length = 381
Score = 49.6 bits (113), Expect = 7e-05
Identities = 23/61 (37%), Positives = 34/61 (55%), Gaps = 2/61 (3%)
Frame = +1
Query: 517 PCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAIEYCN 690
PC+FVCENN + + T + +AS + + +PG +VDG DV+A E A E+
Sbjct: 203 PCLFVCENNQWAISTHIRHQTASENIHIKAKAYGMPGFYVDGNDVVAVMEVCHHAAEWVR 262
Query: 691 A 693
A
Sbjct: 263 A 263
Score = 33.9 bits (74), Expect = 3.8
Identities = 21/63 (33%), Positives = 29/63 (46%), Gaps = 2/63 (3%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVAFAHKYRA 425
GV + ++S+ G T RG+ H R NF + + +QVP AG A A KY
Sbjct: 112 GVPMFTLISQCLGSNTDECRGRQMPHHFSSRAHNFVSASSSIASQVPPAAGNARAQKYLG 171
Query: 426 DGE 434
E
Sbjct: 172 TDE 174
>UniRef50_Q98FT3 Cluster: Acetoin dehydrogenase (TPP-dependent)
alpha chain; n=6; Bacteria|Rep: Acetoin dehydrogenase
(TPP-dependent) alpha chain - Rhizobium loti
(Mesorhizobium loti)
Length = 342
Score = 49.6 bits (113), Expect = 7e-05
Identities = 23/66 (34%), Positives = 36/66 (54%), Gaps = 2/66 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHK 416
++ G V + +E G+ TG +G+GGSMH+ + G NGIVG +P+ G A + K
Sbjct: 91 IAKGAEVKRMFAEFFGKTTGYCKGRGGSMHIADVAKGNLGANGIVGGGIPIAVGAALSSK 150
Query: 417 YRADGE 434
G+
Sbjct: 151 MMKTGK 156
Score = 48.4 bits (110), Expect = 2e-04
Identities = 28/62 (45%), Positives = 34/62 (54%), Gaps = 2/62 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGD--YVPGVWVDGMDVLATREAARFAIEYC 687
LP +FVCENNGYGM TS RS+A R +PGV V+G EA+ A+E
Sbjct: 184 LPVIFVCENNGYGMSTSTARSTAVKNIADRAAAYSMPGVIVNGNIFSEVAEASYRAVERA 243
Query: 688 NA 693
A
Sbjct: 244 RA 245
Score = 41.1 bits (92), Expect = 0.025
Identities = 19/66 (28%), Positives = 36/66 (54%)
Frame = +1
Query: 40 TSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVIT 219
++E ++ ++ ++RR E + Y +I G HL GQEA A+G+ + + D + +
Sbjct: 23 SAEQLREVLYKMYLIRRFEEGAEESYMRGLIHGTMHLSIGQEASAMGICMPLGEDDQITS 82
Query: 220 AYRCHG 237
+R HG
Sbjct: 83 THRGHG 88
>UniRef50_A0LFE6 Cluster: Pyruvate dehydrogenase; n=1;
Syntrophobacter fumaroxidans MPOB|Rep: Pyruvate
dehydrogenase - Syntrophobacter fumaroxidans (strain DSM
10017 / MPOB)
Length = 320
Score = 49.6 bits (113), Expect = 7e-05
Identities = 61/226 (26%), Positives = 93/226 (41%), Gaps = 16/226 (7%)
Frame = +1
Query: 40 TSEDALKLYEQLTILRRIETASGNLYK-EKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 216
T E L++ + + RR E L + E + G L +GQEAVA G+ AA+ D ++
Sbjct: 4 TKEKLLEMLRSMLLTRRFEEKLTELCQIEGKVPGMMILCTGQEAVAAGVCAALEPQDVIV 63
Query: 217 TAYRCHGWTYLMG-------LVCWGCSRS-*RG-AGPVAPGAREVPCICTDATSMVATGL 369
+R HG G C+G +G +G + EV +CT T++V G+
Sbjct: 64 PNHRSHGHLLARGADPNALMAECFGKRTGFNKGKSGTLHVAVPEVNALCT--TTVVGGGI 121
Query: 370 LVRRS-RWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNG 546
+ + ++ + GS +L DLP +FVCENN
Sbjct: 122 PIAAGVAFAQKYRKQKNVT-----VCFFGDGAADEGSFHEALNLAALWDLPVLFVCENNL 176
Query: 547 YGMGTSVDRSSASTEYYTRG-DY-VPGVWVDGMD---VLATREAAR 669
Y + + + R Y +PG+ VDG D V A E AR
Sbjct: 177 YAGAQRYEEHTKIRDMADRAVAYGIPGIVVDGNDARVVYAAAERAR 222
Score = 48.4 bits (110), Expect = 2e-04
Identities = 24/62 (38%), Positives = 37/62 (59%), Gaps = 2/62 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGR--NFYGGNGIVGAQVPLGAGVAFAHK 416
L+ G +++E G+RTG ++GK G++H+ N +VG +P+ AGVAFA K
Sbjct: 73 LARGADPNALMAECFGKRTGFNKGKSGTLHVAVPEVNALCTTTVVGGGIPIAAGVAFAQK 132
Query: 417 YR 422
YR
Sbjct: 133 YR 134
Score = 33.5 bits (73), Expect = 5.0
Identities = 13/42 (30%), Positives = 24/42 (57%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
P+ + + +++ VT +GDGAA++G EA N++ L
Sbjct: 122 PIAAGVAFAQKYRKQKNVTVCFFGDGAADEGSFHEALNLAAL 163
>UniRef50_A4X7T3 Cluster: Dehydrogenase, E1 component; n=3;
Actinomycetales|Rep: Dehydrogenase, E1 component -
Salinispora tropica CNB-440
Length = 323
Score = 49.2 bits (112), Expect = 9e-05
Identities = 54/223 (24%), Positives = 82/223 (36%), Gaps = 9/223 (4%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 216
+T +++LY + ++RR E + L + I G H Y GQE +A G+ AA+R D V
Sbjct: 1 MTEVGSVRLYRTVRLIRRFEERAIELVRSGHIVGGIHPYVGQEGIAAGVCAALRPDDVVA 60
Query: 217 TAYRCHGWTY--------LMGLVCWGCSRS*RGAGPVAPGAREVPCICTDATSMVATGLL 372
+R HG +M +C + RG G A + + A G +
Sbjct: 61 GTHRGHGHVLAKGADPARMMAELCGRVTGLNRGRGGSMHAADFAVGVLGANAIVGAGGAI 120
Query: 373 VRRSRWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYG 552
V + W + G L + +P +FVCENNGY
Sbjct: 121 VTGAVWARRRRGDDLVGVS-----FLGDGAVNEGMLLEAFNLAALWRVPVLFVCENNGYA 175
Query: 553 MGTSV-DRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAI 678
V D + S + VDG D A + A+
Sbjct: 176 TTMPVADAVAGSIPARAEAFGIRTSVVDGQDPAAVQATTAAAL 218
Score = 47.2 bits (107), Expect = 4e-04
Identities = 25/64 (39%), Positives = 35/64 (54%), Gaps = 2/64 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHK 416
L+ G +++EL GR TG +RG+GGSMH + G N IVGA + G +A +
Sbjct: 70 LAKGADPARMMAELCGRVTGLNRGRGGSMHAADFAVGVLGANAIVGAGGAIVTGAVWARR 129
Query: 417 YRAD 428
R D
Sbjct: 130 RRGD 133
Score = 32.7 bits (71), Expect = 8.8
Identities = 16/32 (50%), Positives = 21/32 (65%), Gaps = 3/32 (9%)
Frame = +2
Query: 422 RRRG---VTFALYGDGAANQGQLFEAYNMSKL 508
RRRG V + GDGA N+G L EA+N++ L
Sbjct: 129 RRRGDDLVGVSFLGDGAVNEGMLLEAFNLAAL 160
>UniRef50_Q748I3 Cluster: Dehydrogenase, E1 component, alpha and
beta subunits; n=1; Geobacter sulfurreducens|Rep:
Dehydrogenase, E1 component, alpha and beta subunits -
Geobacter sulfurreducens
Length = 652
Score = 48.8 bits (111), Expect = 1e-04
Identities = 28/68 (41%), Positives = 39/68 (57%)
Frame = +3
Query: 210 SNHRVSLSRMDLSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPL 389
SNHR + L+ V G+++E+ G+ G G GGS HL+ NF+ NGI G VP+
Sbjct: 68 SNHRGHGHYIALTG--DVYGLIAEIMGKDDGVCGGVGGSQHLHTENFF-SNGIQGGMVPV 124
Query: 390 GAGVAFAH 413
AG A A+
Sbjct: 125 AAGRALAN 132
Score = 36.7 bits (81), Expect = 0.54
Identities = 18/64 (28%), Positives = 32/64 (50%)
Frame = +1
Query: 46 EDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAY 225
+D +L +R++E L+ E ++ G H GQE V + A++ D+V + +
Sbjct: 11 KDCYELTVTALTIRKVEERLLELFSEGVLNGTIHTCIGQEWTGVAVANALQAGDTVFSNH 70
Query: 226 RCHG 237
R HG
Sbjct: 71 RGHG 74
>UniRef50_Q1NYL5 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=1; Candidatus Sulcia muelleri str. Hc
(Homalodisca coagulata)|Rep: Pyruvate dehydrogenase E1
component alpha subunit - Candidatus Sulcia muelleri
str. Hc (Homalodisca coagulata)
Length = 58
Score = 48.8 bits (111), Expect = 1e-04
Identities = 22/54 (40%), Positives = 35/54 (64%)
Frame = +1
Query: 34 TLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAM 195
T+ ++ LK Y+ ++ R+ E +LY ++ IRGF HLY+GQEA+ G+ AM
Sbjct: 3 TINNDIYLKWYKDMSFWRKFEDKCRSLYLKQKIRGFLHLYNGQEAIPAGLVHAM 56
>UniRef50_Q18CB6 Cluster: Acetoin:2,6-dichlorophenolindophenol
oxidoreductase alpha subunit; n=2; Clostridium
difficile|Rep: Acetoin:2,6-dichlorophenolindophenol
oxidoreductase alpha subunit - Clostridium difficile
(strain 630)
Length = 322
Score = 48.8 bits (111), Expect = 1e-04
Identities = 22/63 (34%), Positives = 36/63 (57%), Gaps = 2/63 (3%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHKYRA 425
G+ + +++EL G+ TG +GKGGSMH+ G NG+VG + + G A +Y+
Sbjct: 77 GIDLNKMMAELMGKETGFCKGKGGSMHIADIESGNLGANGVVGGGLTIAPGAALTQQYKK 136
Query: 426 DGE 434
G+
Sbjct: 137 TGK 139
Score = 43.2 bits (97), Expect = 0.006
Identities = 23/60 (38%), Positives = 31/60 (51%), Gaps = 2/60 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTR-GDY-VPGVWVDGMDVLATREAARFAIEYC 687
LP +F CENN YGM TS+ R TR Y + G+ +DG + + E + A E C
Sbjct: 167 LPIIFYCENNLYGMSTSIKRHMNIESIATRAASYGIEGISIDGYNPIEVYETVQKAAEKC 226
Score = 37.9 bits (84), Expect = 0.23
Identities = 20/75 (26%), Positives = 36/75 (48%)
Frame = +1
Query: 34 TLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSV 213
+++ E L++Y+++ R+ E + ++ G HL GQEA +V A+ D V
Sbjct: 4 SISKETLLEMYKRMNQARKFEEKVSWFFARGMVHGTTHLSVGQEASSVAAVMALEKGDLV 63
Query: 214 ITAYRCHGWTYLMGL 258
+R H MG+
Sbjct: 64 SLTHRGHSQFIGMGI 78
>UniRef50_Q8YDW3 Cluster: 2-OXOISOVALERATE DEHYDROGENASE BETA
SUBUNIT; n=10; Bacteria|Rep: 2-OXOISOVALERATE
DEHYDROGENASE BETA SUBUNIT - Brucella melitensis
Length = 729
Score = 48.0 bits (109), Expect = 2e-04
Identities = 25/56 (44%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Frame = +3
Query: 273 LSELTGRRTGCSRGKGGSMHLYGRNF--YGGNGIVGAQVPLGAGVAFAHKYRADGE 434
L+E+ G G RG+GGSMHL G N IVG VP+ AG A+AH+ G+
Sbjct: 125 LAEILGLSQGFCRGRGGSMHLRWAESGNLGTNAIVGGGVPMAAGAAWAHRRAGKGD 180
Score = 36.7 bits (81), Expect = 0.54
Identities = 22/62 (35%), Positives = 30/62 (48%), Gaps = 2/62 (3%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSASTEYYTRG--DYVPGVWVDGMDV 645
GS L ++ LP F ENN Y + T V+ +A +RG +P VDGMD
Sbjct: 194 GSVLETMNLAAAWKLPICFFIENNRYAVSTHVEEVTAEPRLSSRGLAFGIPSFKVDGMDP 253
Query: 646 LA 651
+A
Sbjct: 254 IA 255
Score = 34.7 bits (76), Expect = 2.2
Identities = 17/58 (29%), Positives = 29/58 (50%)
Frame = +1
Query: 61 LYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 234
+ Q+ ++R E L + ++ G H GQE AVG +MR +D + ++R H
Sbjct: 34 MLSQMHLIRAFEEKVLELAGQGLVHGPAHSAIGQEGGAVGSAVSMRPSDQINGSHRAH 91
>UniRef50_Q49108 Cluster: Pyruvate dehydrogenase EI alpha subunit;
n=5; Mollicutes|Rep: Pyruvate dehydrogenase EI alpha
subunit - Mycoplasma capricolum
Length = 370
Score = 47.6 bits (108), Expect = 3e-04
Identities = 52/229 (22%), Positives = 91/229 (39%), Gaps = 7/229 (3%)
Frame = +1
Query: 19 PATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG-MRAAM 195
P ++ ++ L+ Y+ + + RR + + ++ + F +GQEA V + A
Sbjct: 27 PKLMPKISDQEILEAYKIMNLSRRQDIYQNTMQRQGRLLSFLSS-TGQEACEVAYINALN 85
Query: 196 RDADSVITAYRCHGWTYLMGLVCWGCSRS*RG--AGPVAPGAREV--PCICTDATSMVAT 363
+ D ++ YR + MG + G AG AP P I + AT
Sbjct: 86 KKTDHFVSGYRNNAAWLAMGQLVRNIMLYWIGNEAGGKAPEGVNCLPPNIVIGSQYSQAT 145
Query: 364 GLLVRRSRWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENN 543
G+ + T+T GS G T ++ ++PC+FV ENN
Sbjct: 146 GIAFADKYRKTGGVVVTTTGDGGS----------SEGETYEAMNFAKLHEVPCIFVIENN 195
Query: 544 GYGMGTSVDRSSASTEYYTRG--DYVPGVWVDGMDVLATREAARFAIEY 684
+ + T+ + S + +G +P + VDG D LA + +EY
Sbjct: 196 KWAISTARSEQTKSINFAVKGIATGIPSIIVDGNDYLACIGVFKEVVEY 244
>UniRef50_Q0RVK8 Cluster: Probable pyruvate dehydrogenase; n=1;
Rhodococcus sp. RHA1|Rep: Probable pyruvate
dehydrogenase - Rhodococcus sp. (strain RHA1)
Length = 344
Score = 47.2 bits (107), Expect = 4e-04
Identities = 23/62 (37%), Positives = 35/62 (56%), Gaps = 2/62 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL-YG-RNFYGGNGIVGAQVPLGAGVAFAHK 416
L G++ + E+ GR T SRG+ G H+ Y YG G++GA +P+ AGVA+ +
Sbjct: 93 LGKGMTARDLAMEIMGRATAPSRGRAGETHINYAPARIYGTTGVLGANIPIAAGVAYGVQ 152
Query: 417 YR 422
R
Sbjct: 153 QR 154
Score = 34.7 bits (76), Expect = 2.2
Identities = 20/46 (43%), Positives = 25/46 (54%), Gaps = 2/46 (4%)
Frame = +1
Query: 511 DLPCVFVCENNGYG-MGTSVDR-SSASTEYYTRGDYVPGVWVDGMD 642
DLP +F+CENN Y +S D+ A G +PGV VDG D
Sbjct: 185 DLPVIFICENNLYAEFSSSRDQMRCADVADRAAGYGIPGVVVDGND 230
>UniRef50_Q0LRY7 Cluster: Dehydrogenase, E1 component:Transketolase,
central region:Transketolase-like; n=3; cellular
organisms|Rep: Dehydrogenase, E1
component:Transketolase, central
region:Transketolase-like - Caulobacter sp. K31
Length = 680
Score = 47.2 bits (107), Expect = 4e-04
Identities = 30/88 (34%), Positives = 41/88 (46%), Gaps = 8/88 (9%)
Frame = +1
Query: 19 PATSATLTSEDALK------LYEQLTILRRIETASGNLYKEKIIR--GFCHLYSGQEAVA 174
P T+ T EDA K ++ ++ +R E + L + R G HL +GQE V
Sbjct: 2 PGTNPRATKEDAAKAAFLSEMFGKICFVRAFEEEALRLTQANPPRVAGSMHLCAGQEVVP 61
Query: 175 VGMRAAMRDADSVITAYRCHGWTYLMGL 258
V A+ D D V+ YR HGW GL
Sbjct: 62 VAAMEALGDEDQVVCTYRGHGWALAAGL 89
Score = 41.1 bits (92), Expect = 0.025
Identities = 22/62 (35%), Positives = 35/62 (56%), Gaps = 2/62 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRN--FYGGNGIVGAQVPLGAGVAFAHK 416
L+ G+ V++E+ R TG + G+ GS ++ + F G N IVGA + GVA A++
Sbjct: 85 LAAGLDPEAVMAEICQRSTGLNGGRAGSAYMMAPHTRFIGENSIVGAGTTIACGVAMANR 144
Query: 417 YR 422
R
Sbjct: 145 LR 146
Score = 33.1 bits (72), Expect = 6.6
Identities = 20/76 (26%), Positives = 31/76 (40%), Gaps = 2/76 (2%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDV 645
GS ++ R LP +FV ENNG+ T + RG +P + G D
Sbjct: 164 GSVHEAMAFAAVRKLPVIFVVENNGWSELTPTSDMFHAERLAVRGKAYGIPSATISGTDP 223
Query: 646 LATREAARFAIEYCNA 693
+ R++ A + A
Sbjct: 224 VVVRDSFAMAAAHARA 239
>UniRef50_P37940 Cluster: 2-oxoisovalerate dehydrogenase subunit
alpha; n=37; Firmicutes|Rep: 2-oxoisovalerate
dehydrogenase subunit alpha - Bacillus subtilis
Length = 330
Score = 47.2 bits (107), Expect = 4e-04
Identities = 58/227 (25%), Positives = 87/227 (38%), Gaps = 12/227 (5%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAM-RDADSV 213
LT ++A+ +Y + + R+I+ L + I F GQEA VG A+ R+ D V
Sbjct: 11 LTDQEAVDMYRTMLLARKIDERMWLLNRSGKIP-FVISCQGQEAAQVGAAFALDREMDYV 69
Query: 214 ITAYRCHGWTYLMGLVCWGCSRS*--RGAGPVAPGAREVPCICTDATSMVATGLLVRRSR 387
+ YR G G+ S + A P + G R++P + + TG S
Sbjct: 70 LPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS-GGRQMPGHFGQKKNRIVTG----SSP 124
Query: 388 WELEWPSPTSTAPTG-------SHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNG 546
+ P A G + G LP +F+CENN
Sbjct: 125 VTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQGDFHEGANFAAVHKLPVIFMCENNK 184
Query: 547 YGMGTSVDRSSASTEYYTR--GDYVPGVWVDGMDVLATREAARFAIE 681
Y + D+ A R G +PGV V+G D L +A + A E
Sbjct: 185 YAISVPYDKQVACENISDRAIGYGMPGVTVNGNDPLEVYQAVKEARE 231
>UniRef50_Q3DYK5 Cluster: Dehydrogenase, E1 component; n=3;
Bacteria|Rep: Dehydrogenase, E1 component - Chloroflexus
aurantiacus J-10-fl
Length = 321
Score = 46.8 bits (106), Expect = 5e-04
Identities = 26/62 (41%), Positives = 32/62 (51%), Gaps = 2/62 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTR--GDYVPGVWVDGMDVLATREAARFAIEYC 687
LP V +CENN Y T + R A T+ R G +PGV VDG D A A + A+E
Sbjct: 167 LPMVIICENNQYAYSTPLSRQMAITDIAQRAAGYAMPGVIVDGNDFAAVYRATKEAVERA 226
Query: 688 NA 693
A
Sbjct: 227 RA 228
>UniRef50_Q93N50 Cluster: Pyruvate dehydrogenase alpha subunit; n=4;
Proteobacteria|Rep: Pyruvate dehydrogenase alpha subunit
- Coxiella burnetii
Length = 341
Score = 46.0 bits (104), Expect = 9e-04
Identities = 23/62 (37%), Positives = 37/62 (59%), Gaps = 2/62 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHK 416
L+ G ++ +++EL G+ TG + G+GGSM+L F IV VP+G G+AF+ K
Sbjct: 71 LAKGGNLKALIAELHGKVTGATAGRGGSMNLSDLSVGFVASTAIVANTVPIGVGLAFSQK 130
Query: 417 YR 422
+
Sbjct: 131 LK 132
>UniRef50_Q00TN9 Cluster: Pyruvate dehydrogenase E1 component beta;
n=3; Ostreococcus|Rep: Pyruvate dehydrogenase E1
component beta - Ostreococcus tauri
Length = 835
Score = 46.0 bits (104), Expect = 9e-04
Identities = 24/53 (45%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHLY--GRNFYGGNGIVGAQVPLGAGVA 404
GV V++EL G+ G RG GGSMH+Y NF GG +V Q+P G A
Sbjct: 204 GVDSGAVMAELFGKDGGTCRGTGGSMHVYDMDTNFQGGWALVAEQLPYAVGAA 256
Score = 42.7 bits (96), Expect = 0.008
Identities = 23/66 (34%), Positives = 32/66 (48%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 216
L+ ED K Y + + R E Y IRGF HL +GQE++ + A+R D
Sbjct: 132 LSDEDLSKAYYMMQLCRDFENECNQAYMAGKIRGFMHLDNGQESIPALLNDAIRKDDLKH 191
Query: 217 TAYRCH 234
+ YR H
Sbjct: 192 SYYRDH 197
Score = 35.5 bits (78), Expect = 1.2
Identities = 22/75 (29%), Positives = 35/75 (46%), Gaps = 2/75 (2%)
Frame = +1
Query: 466 QPGSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGM 639
Q G L +LP +F+ +NG + T +A+ E + +G + VPGV VDG
Sbjct: 285 QNGRMAECLNAAAKENLPILFLVIDNGRAINTFTKDVAANQEVFNQGKHYGVPGVLVDGQ 344
Query: 640 DVLATREAARFAIEY 684
+V + R I +
Sbjct: 345 NVQDVLKVGRTVINH 359
>UniRef50_Q0MX87 Cluster: Acetoin dehydrogenase alpha-subunit; n=2;
Bacteria|Rep: Acetoin dehydrogenase alpha-subunit -
consortium cosmid clone pGZ1
Length = 344
Score = 45.6 bits (103), Expect = 0.001
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVA 404
++ G + ++ EL GR +G GKGGSMH+ + G NG+V A +P+ G A
Sbjct: 90 IAKGADLRRMMHELFGRASGFCGGKGGSMHIADFSVGMLGANGVVAAGIPIAVGAA 145
Score = 41.9 bits (94), Expect = 0.014
Identities = 25/57 (43%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSAS--TEYYTRGDYVPGVWVDGMDVLATREAARFAI 678
LP +FVCE+N + T SA RG VP + VDGMDV+A AAR A+
Sbjct: 183 LPMLFVCEDNQWSATTRTAEMSAGDGAAARARGFGVPALEVDGMDVVAVWRAARDAV 239
Score = 37.5 bits (83), Expect = 0.31
Identities = 18/42 (42%), Positives = 26/42 (61%)
Frame = +1
Query: 130 IRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCHGWTYLMG 255
+RG HL +GQEAVA G+ + +R D + + +R HG T G
Sbjct: 52 VRGPLHLSTGQEAVATGVCSQLRADDWLTSTHRGHGHTIAKG 93
>UniRef50_A4XHV5 Cluster: Transketolase, central region; n=3;
Bacteria|Rep: Transketolase, central region -
Caldicellulosiruptor saccharolyticus (strain ATCC 43494
/ DSM 8903)
Length = 823
Score = 45.6 bits (103), Expect = 0.001
Identities = 23/52 (44%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Frame = +3
Query: 267 GVLSELTGRRTGCSRGKGGSMHLYGRNF--YGGNGIVGAQVPLGAGVAFAHK 416
GVL+E+ GR TG +G GGSMH++ F Y N IVG + G A K
Sbjct: 167 GVLAEIFGRETGFQKGLGGSMHVFFPPFGIYPNNAIVGGSADIAVGAALYKK 218
Score = 37.5 bits (83), Expect = 0.31
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 7/80 (8%)
Frame = +1
Query: 40 TSEDALKLYEQLTILRRIETASGNLYKEKIIRGF-------CHLYSGQEAVAVGMRAAMR 198
+ ED L++Y + I+R ET + G HL GQEA AVG +
Sbjct: 40 SDEDLLRIYRDMLIIREFETMLSLIKTRGEYNGIKYDYPGPAHLSIGQEAAAVGQAFILD 99
Query: 199 DADSVITAYRCHGWTYLMGL 258
D + ++R HG GL
Sbjct: 100 KNDFIFGSHRSHGEVIAKGL 119
>UniRef50_A1SN84 Cluster: Pyruvate dehydrogenase; n=12;
Bacteria|Rep: Pyruvate dehydrogenase - Nocardioides sp.
(strain BAA-499 / JS614)
Length = 344
Score = 44.8 bits (101), Expect = 0.002
Identities = 23/64 (35%), Positives = 36/64 (56%), Gaps = 2/64 (3%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRN-FYGGNGIVGAQVPLGAGVAFA-HK 416
++HGV + + +E+ GR G RG+GG MHL+ + + +GI+ P G AFA H+
Sbjct: 100 VAHGVDLRRMTAEIFGREDGLGRGRGGHMHLFDPDTHFSCSGIIAEGYPPALGQAFAFHR 159
Query: 417 YRAD 428
D
Sbjct: 160 QGTD 163
Score = 33.5 bits (73), Expect = 5.0
Identities = 25/65 (38%), Positives = 35/65 (53%), Gaps = 5/65 (7%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY-----VPGVWVDGMDVLATREAARFAI 678
LP VFV E+N +G+ SV R+ AST + D +PG ++G DV +AAR A+
Sbjct: 192 LPVVFVVEDNDWGI--SVPRT-ASTSVASNADRAAAYGIPGERIEGNDVEGVYDAARRAV 248
Query: 679 EYCNA 693
A
Sbjct: 249 ARARA 253
>UniRef50_Q8U4T5 Cluster: 2-oxo acid dehydrogenase subunit E1; n=1;
Haloferax volcanii|Rep: 2-oxo acid dehydrogenase subunit
E1 - Halobacterium volcanii (Haloferax volcanii)
Length = 353
Score = 44.8 bits (101), Expect = 0.002
Identities = 23/61 (37%), Positives = 34/61 (55%), Gaps = 1/61 (1%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNF-YGGNGIVGAQVPLGAGVAFAHKY 419
++ GV + + +E+ GR+TG RGKGG MHL+ + + GI+ P G A A K
Sbjct: 81 IAKGVDLKRMTAEIFGRKTGLCRGKGGHMHLFDPDVNFACAGIIAQGCPPAVGAAMAAKK 140
Query: 420 R 422
R
Sbjct: 141 R 141
Score = 37.1 bits (82), Expect = 0.41
Identities = 26/71 (36%), Positives = 33/71 (46%), Gaps = 2/71 (2%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSASTEYYTR--GDYVPGVWVDGMDV 645
G L SL DLP VFV E+N + + DR + R G +PGV +D D
Sbjct: 159 GGFLESLNLAAVHDLPVVFVVEDNDWAISMPKDRVTDVQNGAQRAAGFDLPGVRIDSDDA 218
Query: 646 LATREAARFAI 678
A EAA A+
Sbjct: 219 TAVYEAAGEAV 229
>UniRef50_UPI00005103B4 Cluster: COG1071: Pyruvate/2-oxoglutarate
dehydrogenase complex, dehydrogenase (E1) component,
eukaryotic type, alpha subunit; n=1; Brevibacterium
linens BL2|Rep: COG1071: Pyruvate/2-oxoglutarate
dehydrogenase complex, dehydrogenase (E1) component,
eukaryotic type, alpha subunit - Brevibacterium linens
BL2
Length = 368
Score = 44.4 bits (100), Expect = 0.003
Identities = 57/229 (24%), Positives = 88/229 (38%), Gaps = 3/229 (1%)
Frame = +1
Query: 4 KLDQGPATSATLTSEDALK-LYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVG 180
+L P + S+ AL LY Q+ ++RR E +L ++ + + +GQEA VG
Sbjct: 26 RLTDTPTEGLRIPSDAALTGLYRQMVLVRRFEAQVTHLTRQGRLATYPSA-AGQEAAEVG 84
Query: 181 MRAAMRDADSVITAYRCHGWTYLMGLVCWGCSRS*RGAGPVAPGAREVPCICTDATSMVA 360
A+ D + YR G+ + RG RE + A + +A
Sbjct: 85 ATTALAPNDWLFPTYRDSAALLTRGVPVAEILAAFRGDWHCGFDPREYHA--SPAATPLA 142
Query: 361 TGLLVRRSRWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCEN 540
T L + + + A T G T + P VFV +N
Sbjct: 143 TQTL-HATGFAMAAKLKGEDAAT---LTFLGDGASSEGDTHEAFNFASVWQTPTVFVLQN 198
Query: 541 NGYGMGTSVDRSSASTEYYTR--GDYVPGVWVDGMDVLATREAARFAIE 681
N Y + T + + +T R G +PG+ VDG DV A A A+E
Sbjct: 199 NQYAISTPLREQTNATMLADRAAGYGMPGLRVDGNDVAAVFAAVAAALE 247
>UniRef50_A5V4J0 Cluster: Pyruvate dehydrogenase; n=2; Sphingomonas
wittichii RW1|Rep: Pyruvate dehydrogenase - Sphingomonas
wittichii RW1
Length = 327
Score = 44.4 bits (100), Expect = 0.003
Identities = 26/62 (41%), Positives = 34/62 (54%), Gaps = 2/62 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTR--GDYVPGVWVDGMDVLATREAARFAIEYC 687
LP +FVC+NN Y TS+ RS+ Y R G + G+ VDG D AAR+AI+
Sbjct: 169 LPVIFVCQNNAYAEHTSMARSTRVDSYAKRAAGYAMEGIRVDGNDPDEMYGAARWAIDRA 228
Query: 688 NA 693
A
Sbjct: 229 RA 230
Score = 43.6 bits (98), Expect = 0.005
Identities = 22/54 (40%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Frame = +3
Query: 276 SELTGRRTGCSRGKGGSMHLY--GRNFYGGNGIVGAQVPLGAGVAFAHKYRADG 431
+E+ GR TG +GKGG MHL + GIVG+ P+ G+A+A K G
Sbjct: 87 AEIAGRVTGACKGKGGPMHLTYPAKGIMVTTGIVGSTAPIANGLAWAAKLEGKG 140
>UniRef50_Q8YDG0 Cluster: 2-OXOISOVALERATE DEHYDROGENASE BETA
SUBUNIT; n=3; Brucella|Rep: 2-OXOISOVALERATE
DEHYDROGENASE BETA SUBUNIT - Brucella melitensis
Length = 725
Score = 44.0 bits (99), Expect = 0.004
Identities = 21/62 (33%), Positives = 32/62 (51%)
Frame = +1
Query: 49 DALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYR 228
D LK Y Q+ ++RR E + K ++ G H GQEA AVG + ++ D + +R
Sbjct: 30 DLLKWYSQMKLIRRFEEKILDFEKAGLVHGPAHASIGQEAAAVGAMSVLKTDDQINGTHR 89
Query: 229 CH 234
H
Sbjct: 90 TH 91
Score = 40.3 bits (90), Expect = 0.044
Identities = 21/55 (38%), Positives = 30/55 (54%), Gaps = 2/55 (3%)
Frame = +3
Query: 258 SVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHK 416
+V +++E+ G TG G+GGSMH+ G + IVG +P AG A A K
Sbjct: 121 AVYRLMAEIMGLNTGYCGGRGGSMHMRDAASGIAGTSAIVGGNIPHAAGYALADK 175
Score = 37.5 bits (83), Expect = 0.31
Identities = 21/70 (30%), Positives = 35/70 (50%), Gaps = 2/70 (2%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYV--PGVWVDGMDV 645
G+T ++ LP +F ENN Y + T + ++ T +R + G+ DGMD+
Sbjct: 195 GATYEAMNIAALYRLPVIFYVENNLYAVSTHIQDATRETRIASRCPMLGFTGIECDGMDI 254
Query: 646 LATREAARFA 675
L+ +A R A
Sbjct: 255 LSVHQAMREA 264
Score = 33.5 bits (73), Expect = 5.0
Identities = 14/42 (33%), Positives = 25/42 (59%)
Frame = +2
Query: 383 PVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKL 508
P + L ++ R+G++ A +GDG + QG +EA N++ L
Sbjct: 165 PHAAGYALADKILNRKGISVAFFGDGPSLQGATYEAMNIAAL 206
>UniRef50_Q0RLC2 Cluster: Pyruvate dehydrogenase E1 component, alpha
subunit; n=2; Bacteria|Rep: Pyruvate dehydrogenase E1
component, alpha subunit - Frankia alni (strain ACN14a)
Length = 342
Score = 44.0 bits (99), Expect = 0.004
Identities = 62/227 (27%), Positives = 84/227 (37%), Gaps = 18/227 (7%)
Frame = +1
Query: 55 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYR-C 231
L L+ T + R + +L I G + GQE A + A +R D V+T YR
Sbjct: 25 LGLFRTATRIARFDEKYRSLMTSGAIGGMYYSPRGQEFAAASVAAHLRRDDYVVTTYRGL 84
Query: 232 HG-----------WTYLMGLVCWGCSRS*RGAGPVAPGAREVPCICTDATSMVATGLLVR 378
H W +G C GP+ A E + T T +V +GL +
Sbjct: 85 HDQIAKGVPLRELWAEYLGKAAGTCGGK---GGPMHVTAPEYGLMVT--TGVVGSGLPIA 139
Query: 379 RSRWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYG-- 552
T + G+ SL LP +FVC+NN Y
Sbjct: 140 NGLALSAQLRGTDQVTVVNFGDGASNI----GAFHESLNLASIWRLPVIFVCQNNRYAEY 195
Query: 553 ----MGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIE 681
GTSVDR + Y+ +PGV VDG D + AA AIE
Sbjct: 196 TPLREGTSVDRIAQRAAAYS----LPGVTVDGNDPIELYNAAGAAIE 238
Score = 35.5 bits (78), Expect = 1.2
Identities = 20/63 (31%), Positives = 34/63 (53%), Gaps = 3/63 (4%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYG---GNGIVGAQVPLGAGVAFAH 413
++ GV + + +E G+ G GKGG MH+ YG G+VG+ +P+ G+A +
Sbjct: 88 IAKGVPLRELWAEYLGKAAGTCGGKGGPMHVTAPE-YGLMVTTGVVGSGLPIANGLALSA 146
Query: 414 KYR 422
+ R
Sbjct: 147 QLR 149
>UniRef50_Q2BFQ9 Cluster: Putative uncharacterized protein; n=1;
Bacillus sp. NRRL B-14911|Rep: Putative uncharacterized
protein - Bacillus sp. NRRL B-14911
Length = 668
Score = 43.6 bits (98), Expect = 0.005
Identities = 27/69 (39%), Positives = 38/69 (55%)
Frame = +3
Query: 210 SNHRVSLSRMDLSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPL 389
SNHR +++G V +++E+ GR TG G+GGS H+ +FY NGI G V
Sbjct: 74 SNHRCHGHY--IAYGAPVDQLIAEVMGRVTGVVGGRGGSQHICYNDFY-TNGIQGGIVGN 130
Query: 390 GAGVAFAHK 416
G A A+K
Sbjct: 131 ATGAALANK 139
Score = 42.7 bits (96), Expect = 0.008
Identities = 21/67 (31%), Positives = 37/67 (55%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 216
L+ E +Y+++ +R +E +L+ + + G H GQEA AV A +++ D V
Sbjct: 14 LSQETIDSMYKKMITIRTLEETLLDLFSKGELFGTTHTSIGQEANAVASMAHIKNGDVVF 73
Query: 217 TAYRCHG 237
+ +RCHG
Sbjct: 74 SNHRCHG 80
>UniRef50_Q1AZ54 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacter
xylanophilus DSM 9941|Rep: Pyruvate dehydrogenase -
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 325
Score = 43.6 bits (98), Expect = 0.005
Identities = 24/58 (41%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTR-GDY-VPGVWVDGMDVLATREAARFAIE 681
LP +++CENN + + SV ++A + R G Y +PG VDG DV+A EA A+E
Sbjct: 170 LPVIWLCENNQWAVSVSVREATAVKQIADRAGAYGMPGEVVDGQDVVAVYEAVSRAVE 227
>UniRef50_A5UVY9 Cluster: Pyruvate dehydrogenase; n=2;
Roseiflexus|Rep: Pyruvate dehydrogenase - Roseiflexus
sp. RS-1
Length = 334
Score = 43.6 bits (98), Expect = 0.005
Identities = 27/58 (46%), Positives = 32/58 (55%), Gaps = 2/58 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRS-SASTEYYTRGDY-VPGVWVDGMDVLATREAARFAIE 681
LP VFVCENN Y + V++ A T Y + GV VDG DV A EAA A+E
Sbjct: 179 LPAVFVCENNQYAISVPVNKEVPAPTVAAKAAGYGMHGVVVDGNDVFAVYEAAHQAME 236
>UniRef50_Q3WCG3 Cluster: Pyruvate dehydrogenase; n=4;
Actinomycetales|Rep: Pyruvate dehydrogenase - Frankia
sp. EAN1pec
Length = 332
Score = 43.2 bits (97), Expect = 0.006
Identities = 23/59 (38%), Positives = 34/59 (57%), Gaps = 3/59 (5%)
Frame = +3
Query: 243 LSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYG---GNGIVGAQVPLGAGVAFA 410
+ GV ++ + E+ GR+ G RGKGG+MH+ R G GIVG+ P+ G+A A
Sbjct: 78 IGKGVPLVEIYGEMLGRQVGSGRGKGGTMHI-ARPDSGVMLSTGIVGSGPPVAVGMAMA 135
Score = 41.9 bits (94), Expect = 0.014
Identities = 25/59 (42%), Positives = 31/59 (52%), Gaps = 2/59 (3%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTR-GDY-VPGVWVDGMDVLATREAARFAIE 681
DLP V VC+NN YG T + + + R G Y +PGV VDG D LA A+E
Sbjct: 170 DLPLVLVCQNNQYGEMTPTEHTMKIAQVADRAGGYGMPGVRVDGNDPLAVLAVLTQAVE 228
>UniRef50_Q1IY28 Cluster: Pyruvate dehydrogenase; n=1; Deinococcus
geothermalis DSM 11300|Rep: Pyruvate dehydrogenase -
Deinococcus geothermalis (strain DSM 11300)
Length = 361
Score = 43.2 bits (97), Expect = 0.006
Identities = 22/56 (39%), Positives = 31/56 (55%), Gaps = 2/56 (3%)
Frame = +1
Query: 517 PCVFVCENNGYGMGTSVDRSSASTEYYTR--GDYVPGVWVDGMDVLATREAARFAI 678
PCVF+ +NNG+ + + +T R G +PGV VDG DVLAT + A+
Sbjct: 188 PCVFILQNNGWAISVPTRTQTRATNLSLRAQGYGIPGVRVDGNDVLATYQVTLEAV 243
>UniRef50_A5U0N1 Cluster: Dehydrogenase E1 component; n=7;
Mycobacterium tuberculosis complex|Rep: Dehydrogenase E1
component - Mycobacterium tuberculosis (strain ATCC
25177 / H37Ra)
Length = 334
Score = 43.2 bits (97), Expect = 0.006
Identities = 23/59 (38%), Positives = 35/59 (59%)
Frame = +1
Query: 58 KLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 234
+LY ++ +LR ++ A L E +I G GQEAV+VG AA+ + D +IT +R H
Sbjct: 18 ELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGEGDVIITTHRPH 76
>UniRef50_A3SJ75 Cluster: 2-oxoisovalerate dehydrogenase beta
subunit; n=1; Roseovarius nubinhibens ISM|Rep:
2-oxoisovalerate dehydrogenase beta subunit -
Roseovarius nubinhibens ISM
Length = 746
Score = 42.7 bits (96), Expect = 0.008
Identities = 23/58 (39%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Frame = +3
Query: 261 VLGVLSELTGRRTGCSRGKGGSMHLY--GRNFYGGNGIVGAQVPLGAGVAFAHKYRAD 428
V SE+ G ++G G+GGSMHL G N IVG +P G A A K R +
Sbjct: 136 VFKTYSEILGLKSGYCGGRGGSMHLREPEAGVLGSNAIVGGNIPHAVGYALADKMRGE 193
Score = 42.3 bits (95), Expect = 0.011
Identities = 20/59 (33%), Positives = 31/59 (52%)
Frame = +1
Query: 58 KLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 234
++ EQL ++R E L KE ++ G H GQE AVG+ +A+ D + +R H
Sbjct: 47 RMLEQLFLIRHFEERLLELSKEGLLHGPAHASIGQEGAAVGLMSALTSGDKINGTHRMH 105
Score = 42.3 bits (95), Expect = 0.011
Identities = 23/55 (41%), Positives = 28/55 (50%), Gaps = 2/55 (3%)
Frame = +1
Query: 517 PCVFVCENNGYGMGTSVDRSSASTEYYTR--GDYVPGVWVDGMDVLATREAARFA 675
P VFV ENN Y + T V + T R G +P + DGMDV+A R A A
Sbjct: 224 PTVFVVENNQYAVSTHVSEQTRETRLSLRGLGLGIPSITFDGMDVIAARRAMETA 278
>UniRef50_A1UJ85 Cluster: Pyruvate dehydrogenase; n=16;
Mycobacterium|Rep: Pyruvate dehydrogenase -
Mycobacterium sp. (strain KMS)
Length = 356
Score = 42.7 bits (96), Expect = 0.008
Identities = 55/212 (25%), Positives = 80/212 (37%), Gaps = 4/212 (1%)
Frame = +1
Query: 28 SATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDAD 207
S L E LYE + + R ++T +L ++ + + GQEA +G A +R D
Sbjct: 25 SRDLPPETLAWLYETMVVTRDLDTEFVHLQRQGELALYASC-RGQEAAQIGATACLRKTD 83
Query: 208 SVITAYRCHGWTYLMGLVCWGCSRS*RGAGPVAPGAREVPCICTDATSM-VAT-GLLVRR 381
+ YR G L G+ + RG G E C S+ + T GL
Sbjct: 84 WLFPQYREIGAFLLRGIAPAQMAAVWRGKWH---GGLEFTAKCCAPISIPIGTQGLHAVG 140
Query: 382 SRWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMGT 561
+ + S L ++ V PCVF +NN + +
Sbjct: 141 AAMAAQRLGEDSVTVAFLGDGATSEGDVHEAMNLAAVYQV-----PCVFFVQNNQWAISV 195
Query: 562 SVDRSSA--STEYYTRGDYVPGVWVDGMDVLA 651
V R A S + G +PGV VDG DVLA
Sbjct: 196 PVQRQVAGPSIAHRAAGYGMPGVRVDGNDVLA 227
>UniRef50_A0K283 Cluster: Pyruvate dehydrogenase; n=4;
Actinobacteria (class)|Rep: Pyruvate dehydrogenase -
Arthrobacter sp. (strain FB24)
Length = 415
Score = 41.9 bits (94), Expect = 0.014
Identities = 52/238 (21%), Positives = 89/238 (37%), Gaps = 13/238 (5%)
Frame = +1
Query: 7 LDQGPATSATLTSEDALKL---YEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAV 177
L + P SA DA KL Y + +RR + + L ++ + + L +GQEA +
Sbjct: 45 LGEDPVFSAYANRLDAEKLRGFYADMAAIRRFDQEATALQRQGQLALWVPL-TGQEAAQI 103
Query: 178 GMRAAMRDADSVITAYRCHGWTYLMGLVCWGCSRS*RGAGPVAPGAREVP------CICT 339
G A + D + YR HG + R RG ++ +
Sbjct: 104 GSGRASQPQDYIFPTYREHGVALTRNVDLAELLRQFRGVSNGGWNPKDTNFHLYTLVLAA 163
Query: 340 DATSMVATGLLVRRSRWELEWPSPTSTAPT---GSHXXXXXXXXXQPGSTLRSLQHV*TR 510
V + ++R + +L + T P + G S+ +
Sbjct: 164 QTPHAVGYAMGIQRDQ-KLAAANATPDQPQEPKAAVMVYFGDGASSEGDVHESMVFASSY 222
Query: 511 DLPCVFVCENNGYGMGT-SVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIE 681
+ P VF C+NN + + S ++ +G PG+ VDG DV+A +A+E
Sbjct: 223 NAPVVFFCQNNHWAISVPSTVQTRVPLADRAKGYGFPGIRVDGNDVIAVHAVTEWALE 280
>UniRef50_Q72GU1 Cluster: 2-oxoisovalerate dehydrogenase subunit
alpha; n=2; Thermus thermophilus|Rep: 2-oxoisovalerate
dehydrogenase subunit alpha - Thermus thermophilus
(strain HB27 / ATCC BAA-163 / DSM 7039)
Length = 367
Score = 41.1 bits (92), Expect = 0.025
Identities = 22/57 (38%), Positives = 29/57 (50%), Gaps = 2/57 (3%)
Frame = +1
Query: 517 PCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAIE 681
P VFVCENN Y + + S + +PG VDGMDVLA+ + A+E
Sbjct: 196 PAVFVCENNFYAISVDYRHQTHSPTIADKAHAFGIPGYLVDGMDVLASYYVVKEAVE 252
>UniRef50_Q9KG99 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
alpha subunit; n=1; Bacillus halodurans|Rep: Pyruvate
dehydrogenase E1 (Lipoamide) alpha subunit - Bacillus
halodurans
Length = 367
Score = 40.7 bits (91), Expect = 0.033
Identities = 54/215 (25%), Positives = 80/215 (37%), Gaps = 6/215 (2%)
Frame = +1
Query: 55 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 234
L +Y+Q+ R + + L ++ I + + GQEA +G A+R D + YR H
Sbjct: 42 LSMYKQMINCREFDEKALKLQRQGRIGTYAS-FKGQEACQIGGALALRPTDWLFPTYRDH 100
Query: 235 GWTYLMGLVCWGCSRS*RGA--GPVAPGAREV-PCICTDATSMV-ATGLLVRRSRWELEW 402
G G G ++P R + P AT M+ A G W
Sbjct: 101 AAISTHGQPWHRIFLYWMGHMDGSLSPDDRNILPPAVPIATQMLHAVGTA---------W 151
Query: 403 PSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSA 582
P S + G +L P +F C+NNGY + ++ SA
Sbjct: 152 ADKLKGNPHVSLVFFGDGATSE-GDFHEALNFAGVYQTPTIFFCQNNGYAISVPFEKQSA 210
Query: 583 STEYYTRG-DY-VPGVWVDGMDVLATREAARFAIE 681
S R Y + G VDG D+ A + AIE
Sbjct: 211 SKTIKQRSVAYDMRGERVDGNDIFAVYLTVKRAIE 245
>UniRef50_Q479Q2 Cluster: Dehydrogenase, E1 component; n=2;
Rhodocyclaceae|Rep: Dehydrogenase, E1 component -
Dechloromonas aromatica (strain RCB)
Length = 320
Score = 40.7 bits (91), Expect = 0.033
Identities = 26/66 (39%), Positives = 35/66 (53%)
Frame = +1
Query: 40 TSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVIT 219
T+ D L+LYEQL ++R E A + I G C GQEA AVG A+ D ++T
Sbjct: 6 TAVDPLRLYEQLLLIRAYENAIVRGSTDGRIPGTC-TSVGQEAAAVGAINALEADDLILT 64
Query: 220 AYRCHG 237
+R G
Sbjct: 65 NHRSAG 70
Score = 38.7 bits (86), Expect = 0.13
Identities = 25/70 (35%), Positives = 38/70 (54%), Gaps = 2/70 (2%)
Frame = +3
Query: 207 LSNHRVSLSRMDLSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNF--YGGNGIVGAQ 380
L+NHR S + L+ G +L+E+ GRR G +G+ GS+H+ + IVG +
Sbjct: 63 LTNHR-SAGHL-LARGADPGRMLAEVMGRRDGYCKGRSGSLHISAKELGVVLTTTIVGGE 120
Query: 381 VPLGAGVAFA 410
+ L GVA A
Sbjct: 121 LSLAPGVALA 130
Score = 33.5 bits (73), Expect = 5.0
Identities = 25/71 (35%), Positives = 35/71 (49%), Gaps = 3/71 (4%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSASTEY---YTRGDYVPGVWVDGMD 642
GS SL +LP +++CENN + R + S+E+ + G +P VDG D
Sbjct: 152 GSFHESLNLAALWNLPVLYICENNQW-QAFVHRREAMSSEHVSDWGAGYGIPARTVDGND 210
Query: 643 VLATREAARFA 675
V A EA R A
Sbjct: 211 VFAVLEATREA 221
>UniRef50_Q02C52 Cluster: Pyruvate dehydrogenase; n=1; Solibacter
usitatus Ellin6076|Rep: Pyruvate dehydrogenase -
Solibacter usitatus (strain Ellin6076)
Length = 340
Score = 40.7 bits (91), Expect = 0.033
Identities = 23/59 (38%), Positives = 29/59 (49%), Gaps = 2/59 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGD--YVPGVWVDGMDVLATREAARFAIEY 684
LP VF+C NN Y T + A RG +P VDG DVLA EA + A+ +
Sbjct: 184 LPVVFICNNNQYAYSTPLHLQMACANVADRGPAYNMPAEIVDGNDVLAVYEATQRAVTH 242
Score = 37.9 bits (84), Expect = 0.23
Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 2/59 (3%)
Frame = +3
Query: 252 GVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFYGGNGIVGAQVPLGAGVAFAHKYR 422
GVS VL++ GR G +RG+ G+MH+ N + A VP+ G A A +Y+
Sbjct: 94 GVSARRVLAQYMGRLGGLTRGRDGNMHMGDMSVNVVSIISALAATVPVATGAALAMRYK 152
>UniRef50_Q020J5 Cluster: Dehydrogenase, E1 component; n=1;
Solibacter usitatus Ellin6076|Rep: Dehydrogenase, E1
component - Solibacter usitatus (strain Ellin6076)
Length = 697
Score = 40.3 bits (90), Expect = 0.044
Identities = 20/75 (26%), Positives = 38/75 (50%), Gaps = 3/75 (4%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVW---VDGMD 642
G SL + LP +++ E+NGY + +++ +A +PG++ +DG D
Sbjct: 168 GEFWESLNIAALKRLPLLYLIEDNGYAISVPIEQQTAGGSISALTAAIPGLFRQEIDGTD 227
Query: 643 VLATREAARFAIEYC 687
A+ +A + A+ YC
Sbjct: 228 FFASWQAMQAAVRYC 242
>UniRef50_Q4MTG0 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=38; Bacilli|Rep: Pyruvate dehydrogenase
E1 component subunit alpha - Bacillus cereus
Length = 371
Score = 40.3 bits (90), Expect = 0.044
Identities = 22/57 (38%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Frame = +1
Query: 517 PCVFVCENNGYGMGTSVDRSSASTEYYTR--GDYVPGVWVDGMDVLATREAARFAIE 681
P +FV +NN Y + T V++ SA+ + + G+ VDGMD LA A FA E
Sbjct: 197 PAIFVVQNNRYAISTPVEKQSAAKTVAQKAVAAGIYGIQVDGMDPLAVYAATAFARE 253
>UniRef50_Q9K3H0 Cluster: Putative pyruvate dehydrogenase alpha
subunit; n=2; Bacteria|Rep: Putative pyruvate
dehydrogenase alpha subunit - Streptomyces coelicolor
Length = 323
Score = 39.9 bits (89), Expect = 0.058
Identities = 20/55 (36%), Positives = 28/55 (50%)
Frame = +3
Query: 267 GVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVGAQVPLGAGVAFAHKYRADG 431
G+L+E+ GR G GGS H+Y R+ Y G+ G +P+ GV K G
Sbjct: 103 GLLAEIMGRAGAVCHGVGGSQHIY-RDRYLSTGVQGQSLPVAVGVGLHLKQAEPG 156
>UniRef50_Q3W421 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp.
EAN1pec|Rep: Pyruvate dehydrogenase - Frankia sp.
EAN1pec
Length = 358
Score = 39.9 bits (89), Expect = 0.058
Identities = 22/60 (36%), Positives = 30/60 (50%), Gaps = 1/60 (1%)
Frame = +1
Query: 517 PCVFVCENNGYGMGT-SVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEYCNA 693
P VF C+NN + + T S +S G PGV VDG DVLA +A+E+ +
Sbjct: 191 PVVFFCQNNQWAISTPSARQSPVPLARRAAGFGFPGVRVDGNDVLAVHAVTTWALEHARS 250
>UniRef50_Q1LFS5 Cluster: Dehydrogenase, E1 component; n=22;
Proteobacteria|Rep: Dehydrogenase, E1 component -
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM
2839)
Length = 367
Score = 39.9 bits (89), Expect = 0.058
Identities = 52/218 (23%), Positives = 84/218 (38%), Gaps = 8/218 (3%)
Frame = +1
Query: 55 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 234
L LY + + R+ + + + + I F GQEA+ VG+ AMR D ++ +YR H
Sbjct: 36 LPLYRAMVLTRQFDLKAIAMQRTGQIGTFASAL-GQEAIGVGVATAMRRDDVLVPSYRDH 94
Query: 235 GWTYLMG------LVCWGCSRS*RGAGPVAPGAREVPCICTDATSMVATGLLVRRSRWEL 396
++ G L+ WG RG+ A C+ A G+ ++L
Sbjct: 95 AAQFVRGVTMTESLLYWGGDE--RGSAFAAVPYDFGNCVPIGTQVGHAAGVAY---TFKL 149
Query: 397 EWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGY--GMGTSVD 570
+ G G + HV P V V NN + M +
Sbjct: 150 RQAPNVAVCILGD--GGTSKGDFYEGMNMAGAWHV-----PLVIVINNNQWAISMPRAKQ 202
Query: 571 RSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEY 684
++A+ +PG +DG DV+A R+ AIE+
Sbjct: 203 TAAATLAQKAIAAGIPGEQIDGNDVIAVRQRVGAAIEH 240
>UniRef50_Q11G20 Cluster: Twin-arginine translocation pathway
signal; n=2; Proteobacteria|Rep: Twin-arginine
translocation pathway signal - Mesorhizobium sp. (strain
BNC1)
Length = 375
Score = 39.9 bits (89), Expect = 0.058
Identities = 53/229 (23%), Positives = 88/229 (38%), Gaps = 17/229 (7%)
Frame = +1
Query: 58 KLYEQLTILRRIE----TASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRD------AD 207
+L + T + RI T + + + RG+ H Y+GQEAVAVG+ +A+R+ AD
Sbjct: 30 QLVDMFTTILRIRWHERTMADKMLTDPNYRGYNHFYAGQEAVAVGVCSALRNSGGVMHAD 89
Query: 208 SVITAYRCHGWTYLMG--LVCWGCSRS*RGAGPVAPGAREVPCICTDATSMVATGLLVRR 381
+ +R G G + R G A E+ +C + ++
Sbjct: 90 LAYSTHRPTGHAIAKGVDMKLMAAENDFRATGLNGGYAAEMH-LCDPEVGFIGADGMIGP 148
Query: 382 SRWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLR---SLQHV*TRDLPCVFVCENNGYG 552
+ S + GS +T +L + LP ++V ENN Y
Sbjct: 149 GP-VIASGSAFAIKARGSDQVVVNFGGDGTYATPHFHSTLNNAALLKLPFIYVLENNLYH 207
Query: 553 MGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAIEYCNA 693
S + + +PG+ VDG DV+ AA+ A++ A
Sbjct: 208 QYAHYSYSCPLKDIADAANTYGIPGIVVDGQDVIQVYNAAKTAVDRARA 256
>UniRef50_Q67ME6 Cluster: Branched-chain alpha-keto acid
dehydrogenase E1 alpha subunit; n=23; Bacteria|Rep:
Branched-chain alpha-keto acid dehydrogenase E1 alpha
subunit - Symbiobacterium thermophilum
Length = 352
Score = 39.5 bits (88), Expect = 0.076
Identities = 23/58 (39%), Positives = 31/58 (53%), Gaps = 2/58 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRG-DY-VPGVWVDGMDVLATREAARFAIE 681
LP +F+ +NN Y + + + A RG Y +PGV VDG DVLA E + A E
Sbjct: 195 LPVIFMVQNNEYAISVPLSQQVAGGSVAARGRGYGMPGVEVDGTDVLAVYEVVKEAHE 252
>UniRef50_A3PXW7 Cluster: Transketolase domain protein; n=4;
Mycobacterium|Rep: Transketolase domain protein -
Mycobacterium sp. (strain JLS)
Length = 721
Score = 39.5 bits (88), Expect = 0.076
Identities = 21/57 (36%), Positives = 30/57 (52%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEY 684
+P +FVCE+NG G+ T R + Y R + + DG D+ AT E R A E+
Sbjct: 211 MPLLFVCEDNGIGISTRTPRGWVARTYSQR-EGLQYFAADGTDLAATIETTRAAAEF 266
>UniRef50_A0LLM4 Cluster: Pyruvate dehydrogenase; n=1;
Syntrophobacter fumaroxidans MPOB|Rep: Pyruvate
dehydrogenase - Syntrophobacter fumaroxidans (strain DSM
10017 / MPOB)
Length = 365
Score = 39.5 bits (88), Expect = 0.076
Identities = 23/62 (37%), Positives = 34/62 (54%), Gaps = 2/62 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRG-DY-VPGVWVDGMDVLATREAARFAIEYC 687
+P VF+C+NN + + R S S + Y +PG+ VDG DVLA AA+ A++
Sbjct: 183 VPAVFICQNNHWAISLPRARQSHSKTLAQKALAYDMPGLQVDGNDVLAVYAAAKEAVDRA 242
Query: 688 NA 693
A
Sbjct: 243 RA 244
>UniRef50_A3RZM3 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=5; Proteobacteria|Rep: Pyruvate dehydrogenase
E1 component alpha subunit - Ralstonia solanacearum
UW551
Length = 368
Score = 39.1 bits (87), Expect = 0.10
Identities = 53/221 (23%), Positives = 83/221 (37%), Gaps = 8/221 (3%)
Frame = +1
Query: 55 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 234
L LY + + R +T + L + + F GQEA+ VG+ +AMR D + +YR H
Sbjct: 36 LALYRAMVLTRAFDTKAIALQRTGKLGTFASSV-GQEAIGVGVASAMRAEDVLFPSYRDH 94
Query: 235 GWTYLMG------LVCWGCSRS*RGAGPVAPGAREVPCICTDATSMVATGLLVRRSRWEL 396
L G L+ WG RG+ A C+ A G + L
Sbjct: 95 SAQLLRGVSMAESLLYWGGDE--RGSCFAAVREDFPNCVPIGTQVCHAVGAAY---AFAL 149
Query: 397 EWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRS 576
+ A G G + + P V + NN + + R
Sbjct: 150 RREPRVAVAVFGD-------GGTSKGDFYEGMNLAGVWNAPLVLIVNNNQWAISVPRSRQ 202
Query: 577 SASTEYYTR--GDYVPGVWVDGMDVLATREAARFAIEYCNA 693
+A+ + + G VDG DV+A R+AA+ A++ A
Sbjct: 203 TAAQTLAQKAIAAGIAGRQVDGNDVIAVRQAAQEALDKARA 243
>UniRef50_Q9LPL5 Cluster: Branched-chain alpha keto-acid
dehydrogenase E1-alpha subunit; n=13; Magnoliophyta|Rep:
Branched-chain alpha keto-acid dehydrogenase E1-alpha
subunit - Arabidopsis thaliana (Mouse-ear cress)
Length = 472
Score = 38.7 bits (86), Expect = 0.13
Identities = 20/59 (33%), Positives = 28/59 (47%), Gaps = 2/59 (3%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAIE 681
+ P VF+C NNG+ + T + S +G + + VDG D LA A R A E
Sbjct: 285 EAPVVFICRNNGWAISTHISEQFRSDGIVVKGQAYGIRSIRVDGNDALAVYSAVRSARE 343
>UniRef50_Q4N1L6 Cluster: Branched-chain alpha keto-acid
dehydrogenase, putative; n=3; Piroplasmida|Rep:
Branched-chain alpha keto-acid dehydrogenase, putative -
Theileria parva
Length = 464
Score = 38.7 bits (86), Expect = 0.13
Identities = 20/62 (32%), Positives = 28/62 (45%), Gaps = 2/62 (3%)
Frame = +1
Query: 508 RDLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAIE 681
R +F C NN Y + T V RG +P + VDG D+ A+ A ++ E
Sbjct: 270 RQAQTIFACRNNSYSISTPVRDQYIGDGIAIRGVALGIPSIRVDGNDLFASYMATKYCRE 329
Query: 682 YC 687
YC
Sbjct: 330 YC 331
>UniRef50_Q9HNV6 Cluster: Pyruvate dehydrogenase alpha subunit; n=1;
Halobacterium salinarum|Rep: Pyruvate dehydrogenase
alpha subunit - Halobacterium salinarium (Halobacterium
halobium)
Length = 322
Score = 38.7 bits (86), Expect = 0.13
Identities = 22/58 (37%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAI 678
D P VF CENN + + +R +AS + D GV VDG D LA E A+
Sbjct: 139 DAPVVFFCENNNWAISLPRERQTASDSIAAKADAYGFEGVQVDGNDPLAVYETVTDAL 196
>UniRef50_A7D3P2 Cluster: Pyruvate dehydrogenase; n=1; Halorubrum
lacusprofundi ATCC 49239|Rep: Pyruvate dehydrogenase -
Halorubrum lacusprofundi ATCC 49239
Length = 382
Score = 38.7 bits (86), Expect = 0.13
Identities = 24/58 (41%), Positives = 32/58 (55%), Gaps = 6/58 (10%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTR-GDY-VPGVWVDGMDVLA----TREAA 666
D P +F C NNG+ + R +AS + + G Y G+ VDGMD LA T+EAA
Sbjct: 190 DTPTLFCCHNNGWAISIPESRQTASDTFAEKAGAYGFEGIRVDGMDPLASYAVTKEAA 247
Score = 35.5 bits (78), Expect = 1.2
Identities = 23/72 (31%), Positives = 34/72 (47%)
Frame = +1
Query: 22 ATSATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRD 201
AT L+ E +Y L RR + + +L ++ I + +GQE AVG A+ D
Sbjct: 35 ATVPDLSDERFRAIYRDLVTTRRFDERAVSLQRQGRIGTYAPC-AGQEGSAVGSTHALAD 93
Query: 202 ADSVITAYRCHG 237
D + YR HG
Sbjct: 94 RDLISYQYREHG 105
>UniRef50_Q8CX87 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
alpha subunit; n=5; Bacillaceae|Rep: Pyruvate
dehydrogenase E1 (Lipoamide) alpha subunit -
Oceanobacillus iheyensis
Length = 358
Score = 38.3 bits (85), Expect = 0.18
Identities = 47/212 (22%), Positives = 82/212 (38%), Gaps = 4/212 (1%)
Frame = +1
Query: 58 KLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCHG 237
+ Y QL +R + + NL ++ I G + GQE VG A+ + D ++ YR H
Sbjct: 37 QFYRQLICMRAFDQKAINLQRQGRI-GTYPGFEGQEGAQVGSALALDEDDWMLPTYRDHA 95
Query: 238 WTYLMGLVCWGCSR-S*RGAGPVAPGAREV-PCICTDATSMVATGLLVRRSRWELEWPSP 411
+ G S + R G + P + + P AT + + ++++ +
Sbjct: 96 ASITFGKSYTILSSWNGRVEGNLPPEGKNILPPSVPIATQLPLAAGIAMANKYKNSSQAV 155
Query: 412 TSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSASTE 591
+ G+ G L P VF +NN Y + T + R S
Sbjct: 156 IAYFGDGA---------TSEGDFHEGLNFASVFQAPVVFFNQNNQYAISTPISRQMNSET 206
Query: 592 YYTRG-DY-VPGVWVDGMDVLATREAARFAIE 681
+ Y +PG+ +DG D+ A + A+E
Sbjct: 207 IVQKSVAYEIPGIRIDGNDIFAAYFETKKALE 238
>UniRef50_Q5KUY4 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
alpha subunit; n=2; Geobacillus|Rep: Pyruvate
dehydrogenase E1 (Lipoamide) alpha subunit - Geobacillus
kaustophilus
Length = 359
Score = 38.3 bits (85), Expect = 0.18
Identities = 53/223 (23%), Positives = 87/223 (39%), Gaps = 6/223 (2%)
Frame = +1
Query: 31 ATLTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADS 210
A + E L+ Y ++ R I+ + ++ I + +SGQEA +G A+ D
Sbjct: 27 AAFSDEWLLRAYREMRRARVIDERLLRMQRQGRIGTYAP-FSGQEAAQIGSALALHKDDW 85
Query: 211 VITAYRCHGWTYLMGLVCWGCSRS*RG--AGPVAP-GAREVPC-ICTDATSMVATGLLVR 378
+ +YR + G+ +G +G P G P I A ++ A G
Sbjct: 86 IFPSYREVAVCLMHGMPLEQFFHYVQGRLSGKRMPEGVNIFPTQIIIAAQTLHAVGCA-- 143
Query: 379 RSRWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMG 558
W S P S + G ++ ++P +F C+NN Y +
Sbjct: 144 -------WASKLKGEPHVSVAYFGDGATSE-GDFHEAMNFAAVYNVPVIFFCQNNQYAIS 195
Query: 559 TSVDRSSASTEYYTRG-DY-VPGVWVDGMDVLATREAARFAIE 681
+ +AS + Y + GV VDG DVLA E + A+E
Sbjct: 196 VPYRKQTASRTIAQKALAYGMKGVLVDGNDVLAVYETMKQAVE 238
>UniRef50_A7K3C9 Cluster: Dehydrogenase E1 component superfamily;
n=10; Gammaproteobacteria|Rep: Dehydrogenase E1
component superfamily - Vibrio sp. Ex25
Length = 398
Score = 38.3 bits (85), Expect = 0.18
Identities = 25/74 (33%), Positives = 41/74 (55%), Gaps = 4/74 (5%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRS-SASTEYYT---RGDYVPGVWVDGM 639
G L S+ ++P VFV NN + + SV RS + ++ + +G +PG+ VDG
Sbjct: 203 GDFLESINCAGAWNIPLVFVVNNNQWAI--SVPRSLQCAADFLSEKAQGAGIPGITVDGN 260
Query: 640 DVLATREAARFAIE 681
DV+A +A + A+E
Sbjct: 261 DVVAVYDATKTALE 274
>UniRef50_P21873 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=33; Bacilli|Rep: Pyruvate dehydrogenase
E1 component subunit alpha - Bacillus stearothermophilus
(Geobacillus stearothermophilus)
Length = 369
Score = 37.9 bits (84), Expect = 0.23
Identities = 19/57 (33%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Frame = +1
Query: 517 PCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAIE 681
P +FV +NN + + T V++ + + + +PG+ VDGMD LA A + A E
Sbjct: 195 PAIFVVQNNRFAISTPVEKQTVAKTLAQKAVAAGIPGIQVDGMDPLAVYAAVKAARE 251
>UniRef50_Q835M4 Cluster: Pyruvate dehydrogenase complex E1
component, alpha subunit; n=10; Bacilli|Rep: Pyruvate
dehydrogenase complex E1 component, alpha subunit -
Enterococcus faecalis (Streptococcus faecalis)
Length = 371
Score = 36.3 bits (80), Expect = 0.71
Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Frame = +1
Query: 523 VFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAIEYCNA 693
VF+ +NNG+ + T ++ +A+ + +PG+ VDGMD LA A+ A ++ A
Sbjct: 199 VFIIQNNGFAISTPREKQTAAKTLAQKAVAAGIPGIQVDGMDPLAVYAIAKEARDWSAA 257
>UniRef50_A6CP23 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
alpha subunit; n=2; Bacillus sp. SG-1|Rep: Pyruvate
dehydrogenase E1 (Lipoamide) alpha subunit - Bacillus
sp. SG-1
Length = 364
Score = 36.3 bits (80), Expect = 0.71
Identities = 48/213 (22%), Positives = 81/213 (38%), Gaps = 8/213 (3%)
Frame = +1
Query: 37 LTSEDALKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVI 216
+T + A + Y + +R + + +L ++ I + + GQEA VG AA+++ D +
Sbjct: 35 ITEQLAKEFYRHMVRIRTFDKKAISLQRQGRIGTYAP-FEGQEASQVGSSAALKEDDWMF 93
Query: 217 TAYRCHGWTYLMG------LVCWGCSRS*RGAGPVAPGAREVPCICTDATSMVATGLLVR 378
+YR HG G L+ W R G V P +++ +AT L
Sbjct: 94 PSYRDHGAAMTFGHSLRNILLFW----KGRNEGCVPPQGKKI----FPPGIPIATQLPHA 145
Query: 379 RSRWELEWPSPTSTAPTGSHXXXXXXXXXQPGSTLRSLQHV*TRDLPCVFVCENNGYGMG 558
E T A G L + P VF +NNG+ +
Sbjct: 146 AGAAYAEMRKGTKNAA----IVYFGDGATSEGDFHEGLNVASVLNAPVVFFNQNNGFAIS 201
Query: 559 TSVDRSSASTEYYTRG-DY-VPGVWVDGMDVLA 651
+ + + + Y +PGV +DG D+ A
Sbjct: 202 VPIKKQMKTKTIAQKALAYDIPGVRIDGNDIFA 234
>UniRef50_Q4L1A7 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=9; Mycoplasma|Rep: Pyruvate dehydrogenase E1
component alpha subunit - Mycoplasma synoviae
Length = 374
Score = 35.9 bits (79), Expect = 0.94
Identities = 21/61 (34%), Positives = 31/61 (50%), Gaps = 2/61 (3%)
Frame = +1
Query: 508 RDLPCVFVCENNGYGMGTSVDRSSASTEYYTRG--DYVPGVWVDGMDVLATREAARFAIE 681
R P VF NN + + T S S+ + VPGV VDG D+LA+ + + A+E
Sbjct: 194 RSWPAVFCVNNNQWAISTPNHLESISSTIAAKAVAAAVPGVVVDGNDLLASYDVIKEAVE 253
Query: 682 Y 684
+
Sbjct: 254 F 254
>UniRef50_P12694 Cluster: 2-oxoisovalerate dehydrogenase subunit
alpha, mitochondrial precursor; n=29; Euteleostomi|Rep:
2-oxoisovalerate dehydrogenase subunit alpha,
mitochondrial precursor - Homo sapiens (Human)
Length = 445
Score = 35.9 bits (79), Expect = 0.94
Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 6/64 (9%)
Frame = +1
Query: 505 TRDLPCVFVCENNGYGMGTSVDRSSASTEYYTRG-DY-VPGVWVDGMDVL----ATREAA 666
T + P +F C NNGY + T RG Y + + VDG DV AT+EA
Sbjct: 255 TLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEAR 314
Query: 667 RFAI 678
R A+
Sbjct: 315 RRAV 318
>UniRef50_Q3E8Q6 Cluster: Uncharacterized protein At5g34780.1; n=1;
Arabidopsis thaliana|Rep: Uncharacterized protein
At5g34780.1 - Arabidopsis thaliana (Mouse-ear cress)
Length = 365
Score = 35.5 bits (78), Expect = 1.2
Identities = 19/59 (32%), Positives = 27/59 (45%), Gaps = 2/59 (3%)
Frame = +1
Query: 511 DLPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAIE 681
+ P VF+C NNG+ + T + S +G + + VDG D LA A A E
Sbjct: 55 EAPVVFICRNNGWAISTHISEQFRSDGIVVKGQAYGIRSIRVDGNDALAVYSAVCSARE 113
>UniRef50_Q8D6Q7 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex, dehydrogenase component, eukaryotic type, alpha
subunit; n=4; Vibrionaceae|Rep: Pyruvate/2-oxoglutarate
dehydrogenase complex, dehydrogenase component,
eukaryotic type, alpha subunit - Vibrio vulnificus
Length = 364
Score = 35.1 bits (77), Expect = 1.6
Identities = 22/72 (30%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Frame = +1
Query: 472 GSTLRSLQHV*TRDLPCVFVCENNGYGMGTSVDRSSAST--EYYTRGDYVPGVWVDGMDV 645
G L S+ LP VFV NN + + A+ +G +PG+ VDG DV
Sbjct: 169 GDFLESINCAGVWHLPLVFVVNNNQWAISVPRQLQCAADLLSEKAKGAGIPGITVDGNDV 228
Query: 646 LATREAARFAIE 681
+A +A A++
Sbjct: 229 VAVYDAVNNALD 240
>UniRef50_Q83DQ6 Cluster: Dehydrogenase, E1 component, alpha
subunit; n=3; Coxiella burnetii|Rep: Dehydrogenase, E1
component, alpha subunit - Coxiella burnetii
Length = 368
Score = 35.1 bits (77), Expect = 1.6
Identities = 21/68 (30%), Positives = 36/68 (52%)
Frame = +1
Query: 55 LKLYEQLTILRRIETASGNLYKEKIIRGFCHLYSGQEAVAVGMRAAMRDADSVITAYRCH 234
L LY ++ ++R+++ + NL + + G GQEAV +GM +AM+ D YR
Sbjct: 39 LYLYRRMALIRQLDNKAINLQRTGKM-GTYPSSRGQEAVGIGMGSAMQKEDIFCPYYRDQ 97
Query: 235 GWTYLMGL 258
G + G+
Sbjct: 98 GALFEHGI 105
>UniRef50_Q2J998 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp.
CcI3|Rep: Pyruvate dehydrogenase - Frankia sp. (strain
CcI3)
Length = 417
Score = 35.1 bits (77), Expect = 1.6
Identities = 20/56 (35%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Frame = +1
Query: 517 PCVFVCENNGYGMGTSVDRSS-ASTEYYTRGDYVPGVWVDGMDVLATREAARFAIE 681
P VF C+NN + + T R S G PG+ VDG DVLA +A++
Sbjct: 245 PVVFFCQNNQWAISTPSRRQSPVRLARRADGFGFPGLRVDGNDVLAVHAVTTWALD 300
>UniRef50_Q9P2K3 Cluster: REST corepressor 3; n=25; Tetrapoda|Rep:
REST corepressor 3 - Homo sapiens (Human)
Length = 495
Score = 35.1 bits (77), Expect = 1.6
Identities = 22/64 (34%), Positives = 29/64 (45%), Gaps = 5/64 (7%)
Frame = -3
Query: 466 GGSVSVQSERDSPSARYLWAKATPAPNGTCAPTIPL-----PP*KLRPYKCMEPPLPREQ 302
G S + E +P A + PAP+ T PT P+ PP LRP P L R+
Sbjct: 373 GKSTDEEEEAQTPQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQP 432
Query: 301 PVLR 290
P L+
Sbjct: 433 PPLQ 436
>UniRef50_Q5LVW0 Cluster: Dehydrogenase/transketolase family
protein; n=23; Proteobacteria|Rep:
Dehydrogenase/transketolase family protein -
Silicibacter pomeroyi
Length = 740
Score = 34.3 bits (75), Expect = 2.9
Identities = 21/59 (35%), Positives = 30/59 (50%), Gaps = 2/59 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRS--SASTEYYTRGDYVPGVWVDGMDVLATREAARFAIEY 684
LP +FVCE+NG G+ T R AS E+ Y +G+D+ T A+ A +Y
Sbjct: 220 LPLLFVCEDNGIGISTKTPRGWIQASMEHRPGIRYFQ---ANGLDIYETYAVAQEAADY 275
>UniRef50_A5NM81 Cluster: Putative uncharacterized protein; n=1;
Methylobacterium sp. 4-46|Rep: Putative uncharacterized
protein - Methylobacterium sp. 4-46
Length = 930
Score = 34.3 bits (75), Expect = 2.9
Identities = 24/86 (27%), Positives = 39/86 (45%), Gaps = 4/86 (4%)
Frame = +3
Query: 195 ARCRLSNHRVSLSRMDLSHGVSVLGVLSELTGRRTGCSRGKGGSMHLYGRNFYGGNGIVG 374
AR L R + ++ HG VL + + L G G+GG ++LYG++ G +
Sbjct: 513 ARGTLDGWRRGVGQLSAGHGRLVLAIATALAGSLVHLVGGEGGGLNLYGQSSKGKTTTLR 572
Query: 375 AQVPL-GAGVA---FAHKYRADGESR 440
A + G G A F +RA ++
Sbjct: 573 AAASVWGRGSADPGFIRSWRATANAQ 598
>UniRef50_A2C5U8 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex, dehydrogenase (E1) component, eukaryotic type,
alpha subunit; n=1; Prochlorococcus marinus str. MIT
9303|Rep: Pyruvate/2-oxoglutarate dehydrogenase complex,
dehydrogenase (E1) component, eukaryotic type, alpha
subunit - Prochlorococcus marinus (strain MIT 9303)
Length = 280
Score = 34.3 bits (75), Expect = 2.9
Identities = 27/82 (32%), Positives = 40/82 (48%), Gaps = 2/82 (2%)
Frame = +3
Query: 180 YESSDARCRLSNHRVSLSRMDLSHGVSVLGVLSELTGRRTGCSRGKGGSMHL--YGRNFY 353
++ +D RC S+HR M L+ +++EL G G +G GGSMHL
Sbjct: 38 FQKTD-RC-FSSHRSH--SMYLALACDPESLIAELHGSAFGSLQGLGGSMHLKELDSGLE 93
Query: 354 GGNGIVGAQVPLGAGVAFAHKY 419
IVG+ + LG G A + K+
Sbjct: 94 ASIPIVGSSIALGVGSALSAKH 115
>UniRef50_A0H3S4 Cluster: Putative uncharacterized protein; n=1;
Chloroflexus aggregans DSM 9485|Rep: Putative
uncharacterized protein - Chloroflexus aggregans DSM
9485
Length = 400
Score = 34.3 bits (75), Expect = 2.9
Identities = 20/63 (31%), Positives = 27/63 (42%)
Frame = -3
Query: 484 EELTLVGGSVSVQSERDSPSARYLWAKATPAPNGTCAPTIPLPP*KLRPYKCMEPPLPRE 305
++ L G+V +R P+ W+ P P G A PP + RP P L R
Sbjct: 169 DDRPLPTGAVRWSDDRPLPTGAVRWSDDRPLPTGAVAQPSASPPARCRPVPWRSPALHR- 227
Query: 304 QPV 296
QPV
Sbjct: 228 QPV 230
Score = 32.7 bits (71), Expect = 8.8
Identities = 18/63 (28%), Positives = 26/63 (41%)
Frame = -3
Query: 484 EELTLVGGSVSVQSERDSPSARYLWAKATPAPNGTCAPTIPLPP*KLRPYKCMEPPLPRE 305
++ L G+V +R P+ W+ P P G A PP + RP C R
Sbjct: 255 DDRPLPTGAVQWSDDRSLPTDAVRWSDDRPLPTGAVAQPSAPPPARCRPVPCGGQMTARC 314
Query: 304 QPV 296
+PV
Sbjct: 315 RPV 317
>UniRef50_A4WDQ0 Cluster: Transcriptional regulator, AraC family;
n=10; Gammaproteobacteria|Rep: Transcriptional
regulator, AraC family - Enterobacter sp. 638
Length = 254
Score = 33.9 bits (74), Expect = 3.8
Identities = 21/63 (33%), Positives = 37/63 (58%)
Frame = -2
Query: 656 LVASTSMPSTHTPGT*SPRV*YSVLADERSTLVPMPYPLFSQTKTQGKSLV*TCCRLRRV 477
+VAS +P +++PG+ RV Y ++ DE T+ +P+ L + Q + L C ++R+
Sbjct: 110 IVASLDLPESYSPGSRDERV-YELILDEIRTMPVLPFHL---PEPQSEPLHQLCQQIRQ- 164
Query: 476 DPG 468
DPG
Sbjct: 165 DPG 167
>UniRef50_Q0W151 Cluster: Pyruvate dehydrogenase complex E1,
transketolase alpha subunit; n=1; uncultured
methanogenic archaeon RC-I|Rep: Pyruvate dehydrogenase
complex E1, transketolase alpha subunit - Uncultured
methanogenic archaeon RC-I
Length = 359
Score = 33.9 bits (74), Expect = 3.8
Identities = 17/49 (34%), Positives = 28/49 (57%), Gaps = 2/49 (4%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRG-DY-VPGVWVDGMDVLAT 654
+P VF+C NN + + T + + + +G Y +P +DGMDVLA+
Sbjct: 183 VPVVFICSNNQFAISTPNPLQTRAETFAQKGIAYGIPSYRLDGMDVLAS 231
>UniRef50_Q2JA37 Cluster: Pyruvate dehydrogenase; n=11;
Actinomycetales|Rep: Pyruvate dehydrogenase - Frankia
sp. (strain CcI3)
Length = 388
Score = 33.5 bits (73), Expect = 5.0
Identities = 19/61 (31%), Positives = 30/61 (49%), Gaps = 2/61 (3%)
Frame = +1
Query: 517 PCVFVCENNGYGMGTSVDRSSA--STEYYTRGDYVPGVWVDGMDVLATREAARFAIEYCN 690
P VF+ +NNGY + + + SA + + G + G VDG D A R A+E+
Sbjct: 206 PVVFLVQNNGYAISVPLAQQSAAPTLAHKAVGHGIIGRLVDGNDAPAVHGVLRAAVEHAR 265
Query: 691 A 693
+
Sbjct: 266 S 266
>UniRef50_A7RZV6 Cluster: Predicted protein; n=6; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 444
Score = 33.5 bits (73), Expect = 5.0
Identities = 20/61 (32%), Positives = 26/61 (42%), Gaps = 2/61 (3%)
Frame = +1
Query: 505 TRDLPCVFVCENNGYGMGTSVDRSSASTEYYTRG-DY-VPGVWVDGMDVLATREAARFAI 678
T D P +F C NNGY + T RG Y + + VDG D+ A + A
Sbjct: 253 TLDAPVIFFCRNNGYAISTPTREQYRGDGIACRGRSYGMLAIRVDGNDIFAVYNVTKKAR 312
Query: 679 E 681
E
Sbjct: 313 E 313
>UniRef50_Q96JP2 Cluster: Myosin-XVB; n=7; Eutheria|Rep: Myosin-XVB
- Homo sapiens (Human)
Length = 1530
Score = 33.5 bits (73), Expect = 5.0
Identities = 19/50 (38%), Positives = 24/50 (48%)
Frame = +2
Query: 380 GPVGSWSGLRPQVPRRRGVTFALYGDGAANQGQLFEAYNMSKLGTCLASS 529
GP G W G Q PR+R T L D A G A ++ LG C ++S
Sbjct: 24 GPAGEWPGATVQQPRQRAPTALLQPDAAGPGGGGVSA-GVAVLGACPSAS 72
>UniRef50_Q5QUK4 Cluster: Alpha keto acid dehydrogenase complex, E1
component, alpha subunit; n=32; Gammaproteobacteria|Rep:
Alpha keto acid dehydrogenase complex, E1 component,
alpha subunit - Idiomarina loihiensis
Length = 395
Score = 33.1 bits (72), Expect = 6.6
Identities = 23/63 (36%), Positives = 31/63 (49%), Gaps = 7/63 (11%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVD-RSSASTEYYTRG-DY-VPGVWVDGMDVL----ATREAARF 672
+P +F C NNGY + T A RG Y + + +DG DV AT+EA R
Sbjct: 207 VPVIFFCRNNGYAISTPAQGEQYAGDGIAPRGIGYGMKTIRIDGNDVFAVLKATQEARRL 266
Query: 673 AIE 681
A+E
Sbjct: 267 AVE 269
>UniRef50_Q4DB65 Cluster: 2-oxoisovalerate dehydrogenase alpha
subunit, putative; n=3; Trypanosoma|Rep:
2-oxoisovalerate dehydrogenase alpha subunit, putative -
Trypanosoma cruzi
Length = 431
Score = 33.1 bits (72), Expect = 6.6
Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Frame = +1
Query: 523 VFVCENNGYGMGTSVDRSSASTEYYTRG-DY-VPGVWVDGMDVLATREAARFAIE 681
+F+ NNGY + T A + RG Y +P VDG D+LA + R A E
Sbjct: 252 LFLIRNNGYAISTPSSSQYAGDGVFARGIGYGIPCARVDGNDILAVFQTVRKARE 306
>UniRef50_Q5KGR5 Cluster: Branched-chain alpha-keto acid
dehydrogenase E1-alpha subunit, putative; n=2;
Filobasidiella neoformans|Rep: Branched-chain alpha-keto
acid dehydrogenase E1-alpha subunit, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 504
Score = 32.7 bits (71), Expect = 8.8
Identities = 17/51 (33%), Positives = 25/51 (49%), Gaps = 2/51 (3%)
Frame = +1
Query: 517 PCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREA 663
PC++ C NNG+ + T + A +RG + + VDG D LA A
Sbjct: 295 PCIWFCRNNGFAISTPIIDQYAGDGIASRGPAYGLDTIRVDGNDALAVYAA 345
>UniRef50_Q8ZUR8 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=3; Pyrobaculum|Rep: Pyruvate dehydrogenase E1 alpha
subunit - Pyrobaculum aerophilum
Length = 372
Score = 32.7 bits (71), Expect = 8.8
Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Frame = +1
Query: 514 LPCVFVCENNGYGMGTSVDRSSASTEYYTRGDY--VPGVWVDGMDVLATREAARFAIE 681
+P F NN Y + V +A + T+ + GV DGMD+LA + A +A+E
Sbjct: 204 VPAAFFIYNNQYAISVPVSIQTAVSRLSTKAAAYGLVGVSADGMDLLAVVKTAMWAVE 261
>UniRef50_Q5VST9 Cluster: Obscurin; n=50; Amniota|Rep: Obscurin - Homo
sapiens (Human)
Length = 7968
Score = 32.7 bits (71), Expect = 8.8
Identities = 26/79 (32%), Positives = 31/79 (39%), Gaps = 10/79 (12%)
Frame = -3
Query: 499 HVVGFEELTLVGGSV-SVQSERDSPS------ARYLWAKATPAPNGTCAP---TIPLPP* 350
H G ++L GG + Q ER SP A + K AP C+P P PP
Sbjct: 7000 HPQGSKQLPSTGGHPGTAQPERPSPDSPWGQPAPFCHPKQGSAPQEGCSPHPAVAPCPPG 7059
Query: 349 KLRPYKCMEPPLPREQPVL 293
P C E PL P L
Sbjct: 7060 SFPPGSCKEAPLVPSSPFL 7078
>UniRef50_Q9Y149 Cluster: Mediator of RNA polymerase II
transcription subunit 15; n=1; Drosophila
melanogaster|Rep: Mediator of RNA polymerase II
transcription subunit 15 - Drosophila melanogaster
(Fruit fly)
Length = 749
Score = 32.7 bits (71), Expect = 8.8
Identities = 14/34 (41%), Positives = 21/34 (61%)
Frame = -2
Query: 326 GTSLAPGATGPAPRQLREHPQHTNPMR*VHP*QR 225
G + APGA GP P Q++ P + N M+ + P Q+
Sbjct: 235 GPNAAPGAGGPGPNQMQGGPMNVNAMQQMPPMQQ 268
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 664,886,313
Number of Sequences: 1657284
Number of extensions: 13735730
Number of successful extensions: 47520
Number of sequences better than 10.0: 151
Number of HSP's better than 10.0 without gapping: 44216
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 47332
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 54545459628
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -