Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= maV30311
(696 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI0000D56743 Cluster: PREDICTED: similar to 3-hydroxyi... 241 9e-63
UniRef50_P31937 Cluster: 3-hydroxyisobutyrate dehydrogenase, mit... 230 2e-59
UniRef50_Q54CX6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3... 225 8e-58
UniRef50_Q399N0 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=7... 221 1e-56
UniRef50_Q7NWA9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=7... 220 3e-56
UniRef50_Q9V8M5 Cluster: Probable 3-hydroxyisobutyrate dehydroge... 209 4e-53
UniRef50_A7UBP6 Cluster: Putative 3-hydroxyisobutyrate dehydroge... 202 5e-51
UniRef50_P28811 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=7... 199 5e-50
UniRef50_Q0K0E2 Cluster: 3-Hydroxyisobutyrate dehydrogenase; n=1... 184 1e-45
UniRef50_Q83D20 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=9... 182 7e-45
UniRef50_Q9A8J9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 180 3e-44
UniRef50_Q22B54 Cluster: 3-hydroxyisobutyrate dehydrogenase fami... 178 9e-44
UniRef50_Q9SUC0 Cluster: Probable 3-hydroxyisobutyrate dehydroge... 175 6e-43
UniRef50_Q2UHA9 Cluster: Predicted dehydrogenase; n=16; Pezizomy... 171 2e-41
UniRef50_A7JGH8 Cluster: Predicted protein; n=1; Francisella tul... 169 7e-41
UniRef50_A0QSJ0 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3... 169 7e-41
UniRef50_P63936 Cluster: Probable 3-hydroxyisobutyrate dehydroge... 166 4e-40
UniRef50_A0C2T7 Cluster: Chromosome undetermined scaffold_145, w... 165 9e-40
UniRef50_A6NVP0 Cluster: Putative uncharacterized protein; n=1; ... 160 3e-38
UniRef50_A3I4V2 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 154 2e-36
UniRef50_Q6C351 Cluster: Yarrowia lipolytica chromosome F of str... 152 7e-36
UniRef50_A1QPH6 Cluster: 3-hydroxyisobutyrate dehydrogenase mmsB... 151 2e-35
UniRef50_Q0QLF5 Cluster: 2-hydroxymethyl glutarate dehydrogenase... 149 8e-35
UniRef50_A0JUJ6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 148 1e-34
UniRef50_UPI00015B4162 Cluster: PREDICTED: similar to MGC108315 ... 147 2e-34
UniRef50_Q4PCH4 Cluster: Putative uncharacterized protein; n=1; ... 147 3e-34
UniRef50_A0GVR3 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 146 3e-34
UniRef50_Q1V2R0 Cluster: MmsB-like protein; n=2; Candidatus Pela... 144 2e-33
UniRef50_Q4ZQL5 Cluster: 3-hydroxyisobutyrate dehydrogenase prec... 141 2e-32
UniRef50_Q1AVA4 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 140 4e-32
UniRef50_A1SIN3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 138 2e-31
UniRef50_Q0URA2 Cluster: Putative uncharacterized protein; n=1; ... 138 2e-31
UniRef50_Q55702 Cluster: Uncharacterized oxidoreductase slr0229;... 136 5e-31
UniRef50_Q8ES28 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 135 8e-31
UniRef50_A3H5R1 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 135 8e-31
UniRef50_Q9K9L1 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 135 1e-30
UniRef50_A0UF54 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 133 5e-30
UniRef50_O34948 Cluster: Uncharacterized oxidoreductase ykwC; n=... 133 5e-30
UniRef50_P0ABQ3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 132 8e-30
UniRef50_Q0UVR9 Cluster: Putative uncharacterized protein; n=1; ... 131 2e-29
UniRef50_A2SP40 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 130 2e-29
UniRef50_A5V0D4 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 130 3e-29
UniRef50_A2U9T6 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 130 3e-29
UniRef50_Q0C8I2 Cluster: Predicted protein; n=3; Pezizomycotina|... 130 3e-29
UniRef50_Q67QX0 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 130 4e-29
UniRef50_Q97XZ7 Cluster: Oxidoreductase; n=6; Thermoprotei|Rep: ... 128 1e-28
UniRef50_Q1QWU9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 127 2e-28
UniRef50_Q41DK0 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 126 5e-28
UniRef50_A0LMG6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=9... 126 5e-28
UniRef50_Q92D17 Cluster: Lin1004 protein; n=10; Bacilli|Rep: Lin... 125 9e-28
UniRef50_Q01ZG6 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 125 1e-27
UniRef50_Q8KL12 Cluster: Probable 6-phosphogluconate dehydrogena... 124 2e-27
UniRef50_Q58PL4 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 124 2e-27
UniRef50_Q4Q7T9 Cluster: 2-hydroxy-3-oxopropionate reductase, pu... 123 4e-27
UniRef50_Q01QM2 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 123 5e-27
UniRef50_Q4KH51 Cluster: 3-hydroxyisobutyrate dehydrogenase fami... 122 6e-27
UniRef50_Q4FMJ3 Cluster: 6-phosphogluconate dehydrogenase; n=2; ... 122 8e-27
UniRef50_Q18X68 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 122 8e-27
UniRef50_Q11FC5 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 122 8e-27
UniRef50_Q930C6 Cluster: Probable; n=8; Alphaproteobacteria|Rep:... 121 2e-26
UniRef50_Q13LQ9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 120 3e-26
UniRef50_Q0SBQ9 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 120 3e-26
UniRef50_A1UP64 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 120 4e-26
UniRef50_Q1GJB9 Cluster: 6-phosphogluconate dehydrogenase NAD-bi... 118 1e-25
UniRef50_Q0LNZ7 Cluster: 3-hydroxyisobutyrate dehydrogenase prec... 118 1e-25
UniRef50_Q2JEV5 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 118 2e-25
UniRef50_Q606G9 Cluster: Oxidoreductase, Gfo/Idh/MocA family; n=... 117 2e-25
UniRef50_Q183P5 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 117 2e-25
UniRef50_Q9LNP0 Cluster: F1L3.35; n=8; Magnoliophyta|Rep: F1L3.3... 117 2e-25
UniRef50_Q89R44 Cluster: Oxidoreductase; n=23; Bacteria|Rep: Oxi... 116 4e-25
UniRef50_Q5WBB8 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 116 4e-25
UniRef50_Q2BFK1 Cluster: Oxidoreductase; n=1; Bacillus sp. NRRL ... 116 6e-25
UniRef50_Q0S5S3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 116 6e-25
UniRef50_Q03UI4 Cluster: 3-hydroxyisobutyrate dehydrogenase rela... 116 6e-25
UniRef50_A0N0V2 Cluster: BtdhL; n=1; Azoarcus anaerobius|Rep: Bt... 116 7e-25
UniRef50_Q5L168 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 115 1e-24
UniRef50_A0FZ96 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 115 1e-24
UniRef50_Q12CU4 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 114 2e-24
UniRef50_A3RRS1 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 114 2e-24
UniRef50_A6SW62 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 113 4e-24
UniRef50_Q89HA0 Cluster: Oxidoreductase; n=1; Bradyrhizobium jap... 112 7e-24
UniRef50_Q55W03 Cluster: Putative uncharacterized protein; n=2; ... 112 7e-24
UniRef50_Q89UN2 Cluster: Bll1384 protein; n=9; Bacteria|Rep: Bll... 112 9e-24
UniRef50_A4IN46 Cluster: 3-hydroxyisobutyrate dehydrogenase-like... 111 2e-23
UniRef50_Q1N6I0 Cluster: Putative oxidoreductase protein; n=1; O... 110 3e-23
UniRef50_A6LT11 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 110 3e-23
UniRef50_A3LTC4 Cluster: 3-hydroxyisobutyrate dehydrogenase-like... 110 3e-23
UniRef50_Q656T5 Cluster: Oxidoreductase-like; n=3; Oryza sativa|... 109 5e-23
UniRef50_A3X9R7 Cluster: 3-hydroxyisobutyrate dehydrogenase fami... 109 6e-23
UniRef50_A0LDJ3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 109 6e-23
UniRef50_Q0RCX7 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 109 8e-23
UniRef50_Q13PY3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 108 1e-22
UniRef50_A3SJ77 Cluster: Probable oxidoreductase; n=1; Roseovari... 108 1e-22
UniRef50_A1R2J4 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 108 1e-22
UniRef50_Q9HLR4 Cluster: Putative uncharacterized protein Ta0161... 108 1e-22
UniRef50_Q830A7 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 107 2e-22
UniRef50_Q84VC8 Cluster: Gamma hydroxybutyrate dehydrogenase-lik... 107 2e-22
UniRef50_Q6UCZ9 Cluster: Predicted oxidoreductase; n=2; environm... 107 3e-22
UniRef50_A5GPC0 Cluster: Hydroxyacid dehydrogenase/reductase fam... 107 3e-22
UniRef50_A3WAC4 Cluster: Dehydrogenase; n=4; Bacteria|Rep: Dehyd... 107 3e-22
UniRef50_Q1QWQ5 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 106 6e-22
UniRef50_Q4WXG9 Cluster: 3-hydroxyisobutyrate dehydrogenase, put... 105 8e-22
UniRef50_A7IE35 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 105 1e-21
UniRef50_A6P2M7 Cluster: Putative uncharacterized protein; n=2; ... 105 1e-21
UniRef50_A5USN9 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 105 1e-21
UniRef50_Q39FA8 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 104 2e-21
UniRef50_A3K497 Cluster: Probable 6-phosphogluconate dehydrogena... 104 2e-21
UniRef50_A0G5F9 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 104 2e-21
UniRef50_A4SWE8 Cluster: 2-hydroxy-3-oxopropionate reductase pre... 104 2e-21
UniRef50_A1B741 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3... 104 2e-21
UniRef50_Q7VYY0 Cluster: Putative oxidoreductase; n=4; Bordetell... 103 3e-21
UniRef50_Q3DYV4 Cluster: NADP oxidoreductase, coenzyme F420-depe... 103 3e-21
UniRef50_Q121N3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 103 3e-21
UniRef50_Q73P00 Cluster: 3-hydroxyacid dehydrogenase family prot... 103 4e-21
UniRef50_Q0F1Y7 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 103 4e-21
UniRef50_Q8TT25 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 103 4e-21
UniRef50_A0LTQ8 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 103 6e-21
UniRef50_Q94B07 Cluster: Gamma hydroxybutyrate dehydrogenase; n=... 103 6e-21
UniRef50_A7PEG7 Cluster: Chromosome chr11 scaffold_13, whole gen... 102 7e-21
UniRef50_A3EW86 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 102 1e-20
UniRef50_Q7WG50 Cluster: Probable oxidoreductase; n=1; Bordetell... 101 1e-20
UniRef50_P77161 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 101 2e-20
UniRef50_A6GTB5 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 99 5e-20
UniRef50_O33730 Cluster: Uncharacterized oxidoreductase Sfri_150... 100 7e-20
UniRef50_Q47AR2 Cluster: NADP oxidoreductase, coenzyme F420-depe... 99 9e-20
UniRef50_Q97ZE5 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=4... 99 9e-20
UniRef50_Q1IQE6 Cluster: 2-hydroxy-3-oxopropionate reductase pre... 99 1e-19
UniRef50_A0G5G5 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 99 1e-19
UniRef50_Q3W9W7 Cluster: 6-phosphogluconate dehydrogenase, NAD b... 98 2e-19
UniRef50_A1WM48 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 98 2e-19
UniRef50_A0JXR2 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 98 2e-19
UniRef50_A6G049 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 97 3e-19
UniRef50_A3VLN6 Cluster: Oxidoreductase; n=1; Rhodobacterales ba... 97 3e-19
UniRef50_A0QUD5 Cluster: 3-hydroxyisobutyrate dehydrogenase fami... 97 3e-19
UniRef50_A3WMG5 Cluster: Probable 3-hydroxyisobutyrate dehydroge... 97 4e-19
UniRef50_Q8U2W2 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 97 4e-19
UniRef50_A6EH53 Cluster: Putative uncharacterized protein; n=1; ... 96 6e-19
UniRef50_A5VEA3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 96 6e-19
UniRef50_A5P0V0 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 96 6e-19
UniRef50_A2C1U6 Cluster: 3-hydroxyisobutyrate dehydrogenase and ... 96 6e-19
UniRef50_UPI00003C03F8 Cluster: PREDICTED: similar to CG4747-PA;... 95 1e-18
UniRef50_A5VBF0 Cluster: 2-hydroxy-3-oxopropionate reductase pre... 95 1e-18
UniRef50_A1ZWM5 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 95 1e-18
UniRef50_Q9L7S0 Cluster: Uncharacterized oxidoreductase yihU; n=... 95 1e-18
UniRef50_Q0FFH2 Cluster: Putative 2-hydroxyacid dehydrogenase; n... 95 1e-18
UniRef50_A6VYD9 Cluster: 2-hydroxy-3-oxopropionate reductase pre... 95 2e-18
UniRef50_A0GI22 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 95 2e-18
UniRef50_Q8PK98 Cluster: 3-hydroxyisobutirate dehydrogenase; n=3... 94 3e-18
UniRef50_Q1YHQ4 Cluster: Putative 2-hydroxy-3-oxopropionate redu... 94 3e-18
UniRef50_Q7WCG3 Cluster: Putative uncharacterized protein; n=2; ... 94 3e-18
UniRef50_Q019Z7 Cluster: Oxidoreductase-like; n=1; Ostreococcus ... 93 4e-18
UniRef50_A6SUL3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 93 6e-18
UniRef50_UPI0000E49FD0 Cluster: PREDICTED: similar to gamma hydr... 93 8e-18
UniRef50_Q9LM23 Cluster: Fructose-bisphosphate aldolase; n=2; Ar... 93 8e-18
UniRef50_Q8VYC5 Cluster: Fructose-bisphosphate aldolase; n=12; c... 93 8e-18
UniRef50_A5FTT0 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 92 1e-17
UniRef50_Q7Q161 Cluster: ENSANGP00000013149; n=11; Culicidae|Rep... 92 1e-17
UniRef50_Q7WNK6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 92 1e-17
UniRef50_Q8EW87 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 91 2e-17
UniRef50_O66454 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3... 91 2e-17
UniRef50_A1GFG2 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 91 2e-17
UniRef50_Q39MY1 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 91 3e-17
UniRef50_Q49A26 Cluster: Cytokine-like nuclear factor n-pac; n=4... 91 3e-17
UniRef50_Q0KC92 Cluster: 3-Hydroxyisobutyrate dehydrogenase; n=1... 89 7e-17
UniRef50_A0K0Z6 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 89 7e-17
UniRef50_A3JU55 Cluster: Predicted dehydrogenase, with NAD(P)-bi... 89 1e-16
UniRef50_A7DSF1 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 89 1e-16
UniRef50_Q89RT2 Cluster: Bll2680 protein; n=1; Bradyrhizobium ja... 89 1e-16
UniRef50_Q5FQ06 Cluster: Putative oxidoreductase; n=1; Gluconoba... 89 1e-16
UniRef50_Q46TQ0 Cluster: UDP-glucose/GDP-mannose dehydrogenase:P... 89 1e-16
UniRef50_Q12H32 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 89 1e-16
UniRef50_A1WJN2 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 89 1e-16
UniRef50_A0R1N4 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 89 1e-16
UniRef50_A1UJF2 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 88 2e-16
UniRef50_UPI00015B4B33 Cluster: PREDICTED: similar to 3-hydroxyi... 88 2e-16
UniRef50_UPI0000D55E08 Cluster: PREDICTED: similar to CG4747-PA;... 88 2e-16
UniRef50_Q9JYH6 Cluster: 3-hydroxyacid dehydrogenase; n=5; Prote... 87 3e-16
UniRef50_Q84H84 Cluster: Putative oxidoreductase; n=1; Arthrobac... 87 4e-16
UniRef50_A0NRG5 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 87 4e-16
UniRef50_A0GPK7 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 87 5e-16
UniRef50_Q2CHC8 Cluster: Oxidoreductase; n=1; Oceanicola granulo... 85 1e-15
UniRef50_Q7NEW9 Cluster: Glr3759 protein; n=3; Bacteria|Rep: Glr... 85 2e-15
UniRef50_A0RU56 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 85 2e-15
UniRef50_Q0QWD5 Cluster: Putative 3-hydroxyisobutyrate dehydroge... 85 2e-15
UniRef50_A7I8V1 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 85 2e-15
UniRef50_Q20XN2 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 83 5e-15
UniRef50_Q4WV01 Cluster: Oxidoreductase, acting on the CH-OH gro... 83 5e-15
UniRef50_A1CAY2 Cluster: Oxidoreductase, acting on the CH-OH gro... 83 5e-15
UniRef50_Q1EPJ1 Cluster: 6-phosphogluconate dehydrogenase NAD-bi... 83 6e-15
UniRef50_Q3W3N3 Cluster: Putative uncharacterized protein; n=1; ... 82 1e-14
UniRef50_Q3W9L4 Cluster: Putative uncharacterized protein; n=1; ... 82 1e-14
UniRef50_Q8UBW3 Cluster: Oxidoredutase; n=1; Agrobacterium tumef... 81 3e-14
UniRef50_A5WG80 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 81 3e-14
UniRef50_UPI0001597301 Cluster: YfjR; n=1; Bacillus amyloliquefa... 81 3e-14
UniRef50_A4ECY9 Cluster: Putative uncharacterized protein; n=1; ... 81 3e-14
UniRef50_Q7NR40 Cluster: Probable 3-hydroxyisobutyrate dehydroge... 80 4e-14
UniRef50_Q9RX16 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=6... 80 6e-14
UniRef50_Q8F4I7 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=4... 80 6e-14
UniRef50_Q0BTJ3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 80 6e-14
UniRef50_A0QZR7 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 80 6e-14
UniRef50_Q5LQR0 Cluster: 6-phosphogluconate dehydrogenase domain... 79 1e-13
UniRef50_A5P600 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 79 1e-13
UniRef50_Q4Q9Z1 Cluster: Dehydrogenase-like protein; n=6; Trypan... 79 1e-13
UniRef50_Q1B326 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 78 2e-13
UniRef50_A7DWL2 Cluster: Putative dehydrogenase; n=1; Streptomyc... 78 2e-13
UniRef50_A6VLT0 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 78 2e-13
UniRef50_A0JRK4 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 78 2e-13
UniRef50_A7RG59 Cluster: Predicted protein; n=1; Nematostella ve... 77 3e-13
UniRef50_A7H7Z5 Cluster: 6-phosphogluconate dehydrogenase NAD-bi... 77 4e-13
UniRef50_A1SQ87 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 77 4e-13
UniRef50_Q89M84 Cluster: Blr4309 protein; n=6; Bradyrhizobiaceae... 77 5e-13
UniRef50_A3ET09 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3... 77 5e-13
UniRef50_A3Y8R5 Cluster: Putative dehydrogenase; n=1; Marinomona... 76 7e-13
UniRef50_Q5LNV6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 76 1e-12
UniRef50_Q3WJ00 Cluster: 6-phosphogluconate dehydrogenase, NAD b... 75 1e-12
UniRef50_O34969 Cluster: Uncharacterized oxidoreductase yfjR; n=... 75 2e-12
UniRef50_Q0RIL5 Cluster: Putative uncharacterized protein; n=1; ... 74 3e-12
UniRef50_Q6F842 Cluster: Putative 3-hydroxyisobutyrate dehydroge... 74 4e-12
UniRef50_Q221W9 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 73 5e-12
UniRef50_A0K107 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 73 9e-12
UniRef50_Q98I20 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 71 2e-11
UniRef50_A6F020 Cluster: Putative uncharacterized protein; n=1; ... 71 3e-11
UniRef50_P71825 Cluster: Uncharacterized oxidoreductase Rv0770/M... 71 3e-11
UniRef50_Q9I1R8 Cluster: Probable dehydrogenase; n=7; Pseudomona... 71 4e-11
UniRef50_A1WEB7 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 70 5e-11
UniRef50_A0R1N5 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 70 5e-11
UniRef50_A4S5A4 Cluster: Predicted protein; n=2; Ostreococcus|Re... 70 6e-11
UniRef50_A0YMN9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3... 69 8e-11
UniRef50_Q74D68 Cluster: 3-hydroxyisobutyrate dehydrogenase fami... 69 1e-10
UniRef50_Q01PV6 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 69 1e-10
UniRef50_A0VSV4 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 68 2e-10
UniRef50_UPI0000EBE4FC Cluster: PREDICTED: hypothetical protein;... 68 3e-10
UniRef50_Q21AH6 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 67 3e-10
UniRef50_Q1GM24 Cluster: 6-phosphogluconate dehydrogenase NAD-bi... 67 3e-10
UniRef50_A1UJF3 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 67 3e-10
UniRef50_Q98K09 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=7... 67 4e-10
UniRef50_A5CN67 Cluster: Putative beta-hydroxyacid dehydrogenase... 67 4e-10
UniRef50_A6RMW8 Cluster: Putative uncharacterized protein; n=2; ... 66 6e-10
UniRef50_Q1NHF5 Cluster: Putative oxidoreductase; n=1; Sphingomo... 66 1e-09
UniRef50_Q39KK8 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 65 1e-09
UniRef50_A3Q3U7 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 65 1e-09
UniRef50_Q1GF31 Cluster: 6-phosphogluconate dehydrogenase NAD-bi... 65 2e-09
UniRef50_Q5LQS2 Cluster: 3-hydroxyisobutyrate dehydrogenase fami... 64 3e-09
UniRef50_Q120Q9 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 64 4e-09
UniRef50_A4FKN9 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 64 4e-09
UniRef50_A3H6C3 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 64 4e-09
UniRef50_A3H9B3 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 63 7e-09
UniRef50_Q6RXW5 Cluster: Succinic semialdehyde dehydrogenase; n=... 62 1e-08
UniRef50_Q13VQ8 Cluster: Putative dehydrogenase/oxidoreductase p... 62 1e-08
UniRef50_A6R0U9 Cluster: Predicted protein; n=1; Ajellomyces cap... 62 1e-08
UniRef50_Q89GM2 Cluster: Bll6323 protein; n=6; Proteobacteria|Re... 62 2e-08
UniRef50_Q21ZT0 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 62 2e-08
UniRef50_A3PRM1 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 61 2e-08
UniRef50_A3ES45 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 61 3e-08
UniRef50_Q0RMX6 Cluster: Putative reductase; n=1; Frankia alni A... 60 4e-08
UniRef50_Q8T079 Cluster: LD22344p; n=2; Sophophora|Rep: LD22344p... 60 4e-08
UniRef50_Q21ZN3 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 60 5e-08
UniRef50_Q1V2K7 Cluster: NADP oxidoreductase, coenzyme F420-depe... 60 5e-08
UniRef50_A7CWR7 Cluster: 6-phosphogluconate dehydrogenase NAD-bi... 60 5e-08
UniRef50_Q55JR1 Cluster: Putative uncharacterized protein; n=2; ... 60 7e-08
UniRef50_Q2JEN4 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 59 1e-07
UniRef50_A1UDJ6 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 58 2e-07
UniRef50_Q1NHG5 Cluster: Putative uncharacterized protein; n=1; ... 57 5e-07
UniRef50_A0AWL7 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 57 5e-07
UniRef50_Q5GUM4 Cluster: Dehydrogenase; n=5; Gammaproteobacteria... 56 8e-07
UniRef50_Q033P2 Cluster: 3-hydroxyisobutyrate dehydrogenase rela... 56 8e-07
UniRef50_A1WS34 Cluster: Putative uncharacterized protein; n=1; ... 54 3e-06
UniRef50_Q5MZU3 Cluster: 3-hydroxyacid dehydrogenase; n=3; Cyano... 54 4e-06
UniRef50_Q8YRT5 Cluster: 3-hydroxyacid dehydrogenase; n=5; Cyano... 53 6e-06
UniRef50_Q6D9X4 Cluster: Putative 2-hydroxy-3-oxopropionate redu... 53 6e-06
UniRef50_A4JSC3 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 53 8e-06
UniRef50_Q392H4 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 52 1e-05
UniRef50_A0FZ97 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 52 1e-05
UniRef50_Q9K9H3 Cluster: 6-phosphogluconate dehydrogenase; n=7; ... 52 2e-05
UniRef50_A4BV63 Cluster: 3-hydroxyacid dehydrogenase; n=1; Nitro... 51 3e-05
UniRef50_Q0W2D7 Cluster: Putative 6-phosphogluconate dehydrogena... 50 4e-05
UniRef50_A5FVG0 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 50 5e-05
UniRef50_Q629W3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 50 7e-05
UniRef50_Q5FU44 Cluster: Putative oxidoreductase; n=1; Gluconoba... 49 1e-04
UniRef50_A1C8I6 Cluster: NAD binding NADP oxidoreductase coenzym... 49 1e-04
UniRef50_Q0SAG5 Cluster: Phosphogluconate dehydrogenase; n=23; A... 48 2e-04
UniRef50_A4EEN1 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 48 2e-04
UniRef50_A5GJY3 Cluster: 3-hydroxyisobutyrate dehydrogenase rela... 48 2e-04
UniRef50_A3PSD9 Cluster: 6-phosphogluconate dehydrogenase, decar... 48 3e-04
UniRef50_Q1INE9 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 47 4e-04
UniRef50_Q19TN0 Cluster: 3-hydroxyisobutyrate dehydrogenase fami... 47 4e-04
UniRef50_Q4WSB8 Cluster: 6-phosphogluconate dehydrogenase family... 47 4e-04
UniRef50_UPI0000F1E276 Cluster: PREDICTED: similar to G protein-... 46 9e-04
UniRef50_Q9RBX6 Cluster: IgiB; n=1; Vogesella indigofera|Rep: Ig... 46 9e-04
UniRef50_A6ELE2 Cluster: 6-phosphogluconate dehydrogenase, decar... 46 9e-04
UniRef50_Q82ZC2 Cluster: 6-phosphogluconate dehydrogenase family... 43 0.008
UniRef50_Q2UET7 Cluster: Predicted protein; n=7; Eurotiomycetida... 42 0.011
UniRef50_Q9RU02 Cluster: 6-phosphogluconate dehydrogenase; n=24;... 42 0.019
UniRef50_Q0U6Q6 Cluster: Putative uncharacterized protein; n=5; ... 42 0.019
UniRef50_P80859 Cluster: 6-phosphogluconate dehydrogenase, decar... 42 0.019
UniRef50_Q8EW86 Cluster: HAD superfamily hydrolase; n=1; Mycopla... 41 0.025
UniRef50_Q836Q9 Cluster: 6-phosphogluconate dehydrogenase, decar... 41 0.033
UniRef50_Q7TZG1 Cluster: 6-phosphogluconate dehydrogenase, decar... 41 0.033
UniRef50_A6T947 Cluster: Putative dehydrogenase; n=1; Klebsiella... 41 0.033
UniRef50_O66788 Cluster: 6-phosphogluconate dehydrogenase; n=2; ... 40 0.044
UniRef50_Q9CDN4 Cluster: 6-phosphogluconate dehydrogenase; n=12;... 40 0.058
UniRef50_Q53WI1 Cluster: Putative uncharacterized protein TTHB24... 40 0.058
UniRef50_Q92P61 Cluster: 6-phosphogluconate dehydrogenase, decar... 39 0.10
UniRef50_Q64V77 Cluster: 6-phosphogluconate dehydrogenase, decar... 39 0.13
UniRef50_Q5B0A2 Cluster: Putative uncharacterized protein; n=1; ... 38 0.18
UniRef50_Q0V6D4 Cluster: Putative uncharacterized protein; n=1; ... 38 0.24
UniRef50_P37754 Cluster: 6-phosphogluconate dehydrogenase, decar... 38 0.24
UniRef50_Q4RNR1 Cluster: Chromosome 2 SCAF15010, whole genome sh... 38 0.31
UniRef50_O32911 Cluster: 6-phosphogluconate dehydrogenase, decar... 38 0.31
UniRef50_Q9F3P6 Cluster: Putative dehydrogenase; n=1; Streptomyc... 36 1.3
UniRef50_P21577 Cluster: 6-phosphogluconate dehydrogenase, decar... 36 1.3
UniRef50_Q1DDR1 Cluster: 6-phosphogluconate dehydrogenase, decar... 35 2.2
UniRef50_Q1AZK2 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 34 2.9
UniRef50_A5BSQ5 Cluster: Putative uncharacterized protein; n=1; ... 34 2.9
UniRef50_Q0HQ96 Cluster: CHAP domain containing protein precurso... 33 5.1
UniRef50_Q5G5C1 Cluster: Parcxpwnx04; n=1; Periplaneta americana... 33 5.1
UniRef50_Q9RNC5 Cluster: Putative 3-hydroxyacid dehydrogenase; n... 33 6.7
UniRef50_Q0F1E8 Cluster: Putative uncharacterized protein; n=1; ... 33 8.8
UniRef50_A6PRE0 Cluster: MATE efflux family protein; n=1; Victiv... 33 8.8
>UniRef50_UPI0000D56743 Cluster: PREDICTED: similar to
3-hydroxyisobutyrate dehydrogenase; n=1; Tribolium
castaneum|Rep: PREDICTED: similar to
3-hydroxyisobutyrate dehydrogenase - Tribolium castaneum
Length = 315
Score = 241 bits (591), Expect = 9e-63
Identities = 113/229 (49%), Positives = 151/229 (65%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
V++++L + +V D LG +G++ HA KGSLLID STI P V +++ G F DA
Sbjct: 80 VIITMLPNGDIVKDTVLGTNGILKHASKGSLLIDCSTIQPQVAQEVSKATYSAGFKFLDA 139
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PVSGGV GA+ TL FM GG K+ + P+L MGA HCG G+GQ+AKL NN+++
Sbjct: 140 PVSGGVTGAEAGTLTFMVGGDKQVLNSADPILMKMGANVLHCGDSGAGQIAKLCNNLILA 199
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGF 149
IT + T E MN+GIKMGL+PK L ++N S+ RSWS++ Y PVPGL+ P S +Y GGF
Sbjct: 200 ITMIGTCEGMNLGIKMGLDPKTLASIINVSTGRSWSSQTYNPVPGLIEKIPPSNDYKGGF 259
Query: 148 KNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
L+ KDL LA G+AL +P+PL A A Q+YR + GYG KDF+ V
Sbjct: 260 AVNLVAKDLGLAEGVALLCNAPVPLTAAAHQIYRALSCNGYGNKDFASV 308
>UniRef50_P31937 Cluster: 3-hydroxyisobutyrate dehydrogenase,
mitochondrial precursor; n=38; Eumetazoa|Rep:
3-hydroxyisobutyrate dehydrogenase, mitochondrial
precursor - Homo sapiens (Human)
Length = 336
Score = 230 bits (563), Expect = 2e-59
Identities = 109/230 (47%), Positives = 157/230 (68%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D ++++L ++ ++ Y G +G++ KKGSLLIDSSTIDP V K++ + G F D
Sbjct: 97 DRIITMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMD 156
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGGV A++ L FM GG +++F + LL MG+ +CG +G+GQ AK+ NNML+
Sbjct: 157 APVSGGVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLL 216
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
I+ + TAE MN+GI++GL+PK+L +LN SS R WS++ Y PVPG++ PS+ NY GG
Sbjct: 217 AISMIGTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGG 276
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F LM KDL LA A +SPI LG++A Q+YR++ ++GY +KDFS V
Sbjct: 277 FGTTLMAKDLGLAQDSATSTKSPILLGSLAHQIYRMMCAKGYSKKDFSSV 326
>UniRef50_Q54CX6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3;
cellular organisms|Rep: 3-hydroxyisobutyrate
dehydrogenase - Dictyostelium discoideum AX4
Length = 321
Score = 225 bits (550), Expect = 8e-58
Identities = 106/230 (46%), Positives = 154/230 (66%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV+V++L ++ V +VY G++G+ + G+LL+DSSTIDP +++ IA + D
Sbjct: 80 DVIVTMLPASAHVKNVYCGENGIFQTVRPGTLLLDSSTIDPATAREVASIAKKHQSTMLD 139
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
PVSGG GA+ TL FM GG ++DF + L+ MG HCG +G+GQVAK+ NN+++
Sbjct: 140 CPVSGGTGGAEAGTLTFMVGGSEQDFNTAKTYLECMGKNIVHCGDVGTGQVAKVCNNLVL 199
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
GI+ +A +E MN+G+K G++PK L + N SSAR W++E+Y P PG++ T+P+SR Y GG
Sbjct: 200 GISMIAVSEAMNLGVKQGMDPKKLAGIFNTSSARCWTSELYNPCPGVIETSPASRGYTGG 259
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F + LM KDL LA A I P+ LG A QLY ++ ++G GQKDFS V
Sbjct: 260 FGSALMTKDLGLAVDSAKSIGEPLLLGNSAHQLYTLLVAKGDGQKDFSVV 309
>UniRef50_Q399N0 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=72;
cellular organisms|Rep: 3-hydroxyisobutyrate
dehydrogenase - Burkholderia sp. (strain 383)
(Burkholderia cepacia (strain ATCC 17760/ NCIB 9086 /
R18194))
Length = 299
Score = 221 bits (541), Expect = 1e-56
Identities = 110/228 (48%), Positives = 148/228 (64%)
Frame = -3
Query: 685 VVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 506
V+++L + V V G++GV+A G+ +IDSSTIDP + + E G F DAP
Sbjct: 60 VITMLPAAPHVRSVLSGENGVLAGLGAGATVIDSSTIDPASAQAFGALVREHGGAFVDAP 119
Query: 505 VSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGI 326
VSGG GA TL FM GG DFER P+L MG HCG G GQVAK+ NN+++GI
Sbjct: 120 VSGGTGGAAAGTLTFMVGGSDADFERVKPVLAGMGKNIVHCGATGMGQVAKVCNNLVLGI 179
Query: 325 TGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFK 146
+ A +E M++G+ +G++PKVL ++N S+ R WS++ Y P PG++ TAPSSR Y GGF
Sbjct: 180 SMAAVSEAMSLGVALGIDPKVLAGIVNTSTGRCWSSDTYNPYPGVIDTAPSSRGYSGGFG 239
Query: 145 NELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
+LM+KDL LA+ A R P+ LGA+A QLY+ + SRG GQ DFS V
Sbjct: 240 TDLMLKDLGLANDAAKQARQPVYLGALAQQLYQTMSSRGDGQLDFSAV 287
>UniRef50_Q7NWA9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=7;
Proteobacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Chromobacterium violaceum
Length = 296
Score = 220 bits (537), Expect = 3e-56
Identities = 109/229 (47%), Positives = 148/229 (64%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
VV+S+L + K V +YLG +G+ A KG+L+ID STID +++ A EKGL DA
Sbjct: 60 VVISMLPAGKHVAGLYLGDNGLFARLPKGALVIDCSTIDAGTARKVAEGAREKGLSMLDA 119
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PVSGG GA TL F+ GG ED + P+L+ MG FH G G+GQ AK+ NNML+G
Sbjct: 120 PVSGGTAGAAAGTLTFIVGGAAEDLAHARPVLEAMGKNIFHAGGAGAGQTAKICNNMLLG 179
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGF 149
I TAE + +G+K GL+PKVL ++++ SS R+W+TE+Y P PG++ P+SR Y GGF
Sbjct: 180 ILMAGTAEALALGVKNGLDPKVLSEIISKSSGRNWATELYNPWPGVMDNTPASRGYAGGF 239
Query: 148 KNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
+ELM+KDL LA AL + PLGA+A LY +G G+ DFS +
Sbjct: 240 MSELMLKDLGLAEETALQSHAANPLGALARNLYEEHVHQGNGKLDFSSI 288
>UniRef50_Q9V8M5 Cluster: Probable 3-hydroxyisobutyrate
dehydrogenase, mitochondrial precursor; n=4;
Diptera|Rep: Probable 3-hydroxyisobutyrate
dehydrogenase, mitochondrial precursor - Drosophila
melanogaster (Fruit fly)
Length = 324
Score = 209 bits (511), Expect = 4e-53
Identities = 103/232 (44%), Positives = 152/232 (65%), Gaps = 2/232 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVY--LGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGF 518
D V+++L +N +V Y + DGV K ++ IDSSTI P++ K + KG F
Sbjct: 86 DFVITMLPNNAIVDASYDEMTADGV----NKDTIFIDSSTISPDLVKSLQKKISAKGARF 141
Query: 517 TDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNM 338
DAPVSGGV GA+ ATL FM GG + ++ +L+ MG K HCG G GQ AKL NNM
Sbjct: 142 IDAPVSGGVPGAEQATLTFMVGGTEAEYNAVKAVLECMGKKITHCGVYGMGQAAKLCNNM 201
Query: 337 LMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD 158
++ I+ + +E MN+ ++ GL+ V +++N+S+ R W++E+Y PVPG+ P+AP++R+Y
Sbjct: 202 MLAISMIGVSEAMNLAVRQGLDANVFAEIINSSTGRCWASEIYNPVPGVCPSAPANRDYA 261
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
GGF + L+ KDL LASG+A SPIPLG++A ++Y+ + +G G KDFS V
Sbjct: 262 GGFSSALITKDLGLASGVANASNSPIPLGSLAHKVYQSLCDKGLGNKDFSVV 313
>UniRef50_A7UBP6 Cluster: Putative 3-hydroxyisobutyrate
dehydrogenase; n=1; Paracoccus methylutens|Rep: Putative
3-hydroxyisobutyrate dehydrogenase - Paracoccus
methylutens
Length = 302
Score = 202 bits (494), Expect = 5e-51
Identities = 99/230 (43%), Positives = 147/230 (63%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D V++++ + + VL+++LG DGV+A KGS+ IDSSTID +++ E+G+ D
Sbjct: 59 DFVITMVPTGRHVLEIFLGDDGVLAKMAKGSMAIDSSTIDTADARRLHAAGRERGIAVLD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGGVMGA+ TL FM GG ED ER+ P+L+ MG + FH G+ G GQ AKL NN+L
Sbjct: 119 APVSGGVMGAEAGTLTFMVGGSAEDLERARPVLEAMGRRIFHAGEPGVGQAAKLCNNLLA 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
GI+ +A +E + +GL+ + + ++ S+ +S Y PVPGLVP PSSR Y G
Sbjct: 179 GISMIAVSEAFALARHLGLDARKMQEISAVSTGGCFSLTNYPPVPGLVPNVPSSREYRNG 238
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F ++LM+KDL+LA A+ + +PLG +A LY + G+ + D+S +
Sbjct: 239 FASQLMLKDLKLAQQAAIQSGTALPLGGLAAALYGMFCQAGHSELDYSAI 288
>UniRef50_P28811 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=72;
Proteobacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Pseudomonas aeruginosa
Length = 298
Score = 199 bits (486), Expect = 5e-50
Identities = 100/216 (46%), Positives = 139/216 (64%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
+VV+S+L + + V +YLG DG++A LLID STI P +++ A KGL D
Sbjct: 59 EVVISMLPAGQHVESLYLGDDGLLARVAGKPLLIDCSTIAPETARKVAEAAAAKGLTLLD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGGV GA+ TL+F+ GG E F R+ P+L+ MG FH G G+GQVAK+ NNML+
Sbjct: 119 APVSGGVGGARAGTLSFIVGGPAEGFARARPVLENMGRNIFHAGDHGAGQVAKICNNMLL 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
GI TAE + +G+K GL+P VL +V+ SS +W+ +Y P PG++P AP+S Y GG
Sbjct: 179 GILMAGTAEALALGVKNGLDPAVLSEVMKQSSGGNWALNLYNPWPGVMPQAPASNGYAGG 238
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRI 44
F+ LM KDL LA A +++ PLGA+A L+ +
Sbjct: 239 FQVRLMNKDLGLALANAQAVQASTPLGALARNLFSL 274
>UniRef50_Q0K0E2 Cluster: 3-Hydroxyisobutyrate dehydrogenase; n=1;
Ralstonia eutropha H16|Rep: 3-Hydroxyisobutyrate
dehydrogenase - Ralstonia eutropha (strain ATCC 17699 /
H16 / DSM 428 / Stanier 337)(Cupriavidus necator (strain
ATCC 17699 / H16 / DSM 428 / Stanier337))
Length = 299
Score = 184 bits (449), Expect = 1e-45
Identities = 89/229 (38%), Positives = 141/229 (61%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
+V+SI+ + V ++Y GV+ A G+LLI+SSTI P + + A + G DA
Sbjct: 60 IVISIVRNADDVKNLYCTAGGVLDVAAPGALLIESSTIGPAAARAVAAEAAQAGFAMLDA 119
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PV+GG GA+ A L FM GG + F+R+ P+L+ MGA+ F+ G G+GQ+AKL NN++
Sbjct: 120 PVAGGQAGAREARLTFMVGGARTAFDRAEPVLRQMGARIFYAGASGNGQIAKLCNNLIAC 179
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGF 149
++ +E +G K+G++ + + D++ S+ + W+ CPVPG VP++P+SR+Y GF
Sbjct: 180 VSSAVVSEAFILGSKLGMDYQTMYDIITQSTGQCWTLSHNCPVPGPVPSSPASRDYVPGF 239
Query: 148 KNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
+LM+KDL L + A + + P GA A QLYR + G G +D++ V
Sbjct: 240 AADLMLKDLSLVASAASEVGAATPFGARAIQLYRQLSESGLGARDWTVV 288
>UniRef50_Q83D20 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=9;
Proteobacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Coxiella burnetii
Length = 297
Score = 182 bits (443), Expect = 7e-45
Identities = 90/230 (39%), Positives = 139/230 (60%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV ++L ++ V + L G+ A + ++ IDSS+ID +++ A ++G+ D
Sbjct: 59 DVVFTMLQTSDQVRNCCLSAKGIFATINRQAIYIDSSSIDIEGSRELHKEAKKRGISMLD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGGV A+ A L FM GG KEDFER+ +L ++G K + G G+G AK+ NNML+
Sbjct: 119 APVSGGVAAAEAAGLTFMVGGEKEDFERAKRVLGILGKKIIYAGSDGAGAAAKICNNMLL 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
GI+ +A +E + K+GL+P+ L ++ +N+S WS YCP PG++ PSS Y G
Sbjct: 179 GISMIAVSEAFVLADKLGLDPQKLFEISSNASGECWSLTHYCPWPGILKDVPSSHEYKPG 238
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F ++M+KDL L+ A ++ PLG AT+LY+ +G+ DFS +
Sbjct: 239 FTAKMMLKDLNLSQAAASDAKANTPLGKRATELYQQFVDSDHGEVDFSAI 288
>UniRef50_Q9A8J9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=24;
Alphaproteobacteria|Rep: 3-hydroxyisobutyrate
dehydrogenase - Caulobacter crescentus (Caulobacter
vibrioides)
Length = 298
Score = 180 bits (438), Expect = 3e-44
Identities = 92/230 (40%), Positives = 132/230 (57%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
++V+++L + V VY + ++ +A K +LLID STID + + + A E G F D
Sbjct: 59 EIVITMLPAGPHVRAVYA--EQILPNAPKSALLIDCSTIDVDSARVVARQAAEAGFRFAD 116
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG+M A+ TLAFM G DF L M H G G+GQ AK+ NNML+
Sbjct: 117 APVSGGIMAAEAGTLAFMVGCEASDFAAVEAALAPMSRVTIHAGDHGAGQAAKICNNMLL 176
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G++ + T E + K+GL ++ + SS + WS YCPVPG+ P P+ R Y+GG
Sbjct: 177 GVSMLGTCEAFALAEKLGLAADRFFEIASKSSGQCWSITSYCPVPGVGPQTPADRGYEGG 236
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F + +M+KDL+LA A + P+GA A LY + + G+G KDFS V
Sbjct: 237 FASAMMLKDLKLAQEAAAKAGASTPMGAQAEALYALFDANGFGGKDFSAV 286
>UniRef50_Q22B54 Cluster: 3-hydroxyisobutyrate dehydrogenase family
protein; n=1; Tetrahymena thermophila SB210|Rep:
3-hydroxyisobutyrate dehydrogenase family protein -
Tetrahymena thermophila SB210
Length = 316
Score = 178 bits (434), Expect = 9e-44
Identities = 94/228 (41%), Positives = 140/228 (61%), Gaps = 1/228 (0%)
Frame = -3
Query: 682 VSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 503
V++L ++ V V G++G+ + K SL IDSSTI + +I+ A + + DAPV
Sbjct: 78 VTMLPNSSHVSSVLEGENGLFQKSAKNSLFIDSSTISYHAAIKIYENAKKVNQRYIDAPV 137
Query: 502 SGGVMGAQNATLAFMAGGR-KEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGI 326
SGGV A TL FM G KE F+ LL+ MG +C + G+G +AK+ NNM +GI
Sbjct: 138 SGGVGAATAGTLTFMVGAENKELFQECKNLLQHMGKNIANCEKPGAGSIAKICNNMALGI 197
Query: 325 TGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFK 146
+A AE +++G K+G++PKVL ++N +S R WS+EVY P PG++ P+S+ Y+GGF
Sbjct: 198 EMIAVAEAISLGKKLGIDPKVLSSIMNTASGRCWSSEVYNPCPGVLENVPASKGYEGGFA 257
Query: 145 NELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
ELM+KDL LA+ A + +PLG A +Y+ + G +KDF+ V
Sbjct: 258 CELMLKDLGLAADAAKQASADVPLGNHAKDIYQKLVELGLNRKDFAIV 305
>UniRef50_Q9SUC0 Cluster: Probable 3-hydroxyisobutyrate
dehydrogenase, mitochondrial precursor; n=13;
Magnoliophyta|Rep: Probable 3-hydroxyisobutyrate
dehydrogenase, mitochondrial precursor - Arabidopsis
thaliana (Mouse-ear cress)
Length = 347
Score = 175 bits (427), Expect = 6e-43
Identities = 93/242 (38%), Positives = 143/242 (59%), Gaps = 12/242 (4%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAK--KGSLLIDSSTIDPNVPKQIFPIALEKGLG- 521
+VV+++L S+ V+DVY G +G++ + +L IDSSTIDP ++I L
Sbjct: 95 EVVITMLPSSSHVMDVYTGTNGLLLGENDIRPALFIDSSTIDPQTTRKISLAVSNCNLKE 154
Query: 520 ---------FTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGS 368
DAPVSGGV+ A+ TL FM GG ++ + + P+L+ MG +CG G+
Sbjct: 155 KRDNWEKPVMLDAPVSGGVLAAEAGTLTFMVGGPEDAYLAARPILQSMGRTSIYCGGSGN 214
Query: 367 GQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLV 188
G AK+ NN+ M ++ + T+E + +G +G+ L +VLN SS R WS++ Y PVPG++
Sbjct: 215 GSAAKICNNLAMAVSMLGTSEALALGQSLGISASTLTEVLNTSSGRCWSSDAYNPVPGVM 274
Query: 187 PTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
PSSR+Y+GGF ++LM KDL LA+ A + PL + A ++Y+ + G+ KDFS
Sbjct: 275 KGVPSSRDYNGGFASKLMAKDLNLAAASAEEVGHKSPLISKAQEIYKKMCEEGHETKDFS 334
Query: 7 FV 2
V
Sbjct: 335 CV 336
>UniRef50_Q2UHA9 Cluster: Predicted dehydrogenase; n=16;
Pezizomycotina|Rep: Predicted dehydrogenase -
Aspergillus oryzae
Length = 363
Score = 171 bits (415), Expect = 2e-41
Identities = 102/235 (43%), Positives = 139/235 (59%), Gaps = 6/235 (2%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVY--LGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLG-F 518
V+V+ L + V +V+ + + G + +K L ID+STIDP ++I G F
Sbjct: 118 VIVTSLPEPEHVKNVFYCMLRHGELPALEKERLFIDTSTIDPASSREIANAIHTTRQGRF 177
Query: 517 TDAPVSGGVMGAQNATLAFMAGGRKEDFE---RSLPLLKVMGAKQFHCGQIGSGQVAKLT 347
DAP+SGGV+GA+ TL+FM G + E R +L +MG K +H G G+G AKL
Sbjct: 178 VDAPMSGGVVGARAGTLSFMFGASSQTGELVDRVQSVLMLMGKKAWHMGNSGTGVSAKLA 237
Query: 346 NNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSR 167
NN L+ I +ATAE MN+GI+ GL+PKVL D++N S+ R W E+ PVPG+V TAP+SR
Sbjct: 238 NNYLLAINNIATAEVMNLGIRCGLDPKVLADMINTSTGRCWPMEINNPVPGVVETAPASR 297
Query: 166 NYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
Y GGF LM KDL LA A +P+ L A +Y+ V+ G KDFS V
Sbjct: 298 EYAGGFGISLMNKDLRLAISAAEESGTPLALADKARGVYKAVEDEHRG-KDFSVV 351
>UniRef50_A7JGH8 Cluster: Predicted protein; n=1; Francisella
tularensis subsp. novicida GA99-3549|Rep: Predicted
protein - Francisella tularensis subsp. novicida
GA99-3549
Length = 293
Score = 169 bits (410), Expect = 7e-41
Identities = 89/231 (38%), Positives = 129/231 (55%), Gaps = 1/231 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D ++ L V +V DG++ AK G+++ID+STID N + A + L D
Sbjct: 59 DAIILSLPGPNQVSNVCDSSDGILKIAKAGTIIIDTSTIDANTSVLLAKKAKQNNLHMLD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG++GAQNATL FM GG KE FER L MG K H G G G + KL NNML+
Sbjct: 119 APVSGGIIGAQNATLTFMVGGDKEIFERCKNLFNSMGKKYLHVGDNGKGLIIKLINNMLL 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
GI +A +E N K G+ K D++ +S+ SW+ P+P ++ P++ +Y G
Sbjct: 179 GINMIAASEACNFAEKTGINLKTFYDIVASSTGSSWAFNKNFPMPDIIENVPANNDYKPG 238
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLY-RIVQSRGYGQKDFSFV 2
F L++KD+ +A A + LG +A ++Y R++ S +KDFS V
Sbjct: 239 FGAPLIMKDINIAVETAQDYNINLKLGLLAKEIYERMINSEELNKKDFSAV 289
>UniRef50_A0QSJ0 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3;
Bacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length = 290
Score = 169 bits (410), Expect = 7e-41
Identities = 92/230 (40%), Positives = 127/230 (55%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
+VV++ L + +V Y V+ A G+L ID+STI + + + ALEKG D
Sbjct: 59 EVVITSLPNGDIVKSCYAE---VLPAAPTGTLFIDTSTISVDDARTVHTQALEKGHAQLD 115
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGGV GA TLAFM GG + ER+ P+L M K HCG G+GQ AKL NNM++
Sbjct: 116 APVSGGVKGATAGTLAFMVGGEDDAVERARPILDPMAGKIIHCGGSGTGQAAKLCNNMVL 175
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ +A E + K+GL + L DV+ ++ WS CPVPG VPT+P++ ++ G
Sbjct: 176 AVQQIAIGEAFVLAEKLGLSAQSLFDVITGATGNCWSVHTNCPVPGPVPTSPANNDFKPG 235
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F LM KDL LA + PLG+ A ++Y + KDFS V
Sbjct: 236 FATSLMNKDLGLAMAAVSSTGASAPLGSHAAEIYAKFNEE-HADKDFSAV 284
>UniRef50_P63936 Cluster: Probable 3-hydroxyisobutyrate
dehydrogenase; n=25; Bacteria|Rep: Probable
3-hydroxyisobutyrate dehydrogenase - Mycobacterium bovis
Length = 294
Score = 166 bits (404), Expect = 4e-40
Identities = 90/230 (39%), Positives = 130/230 (56%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV+++L + +VV Y V+A A+ +L IDSSTI +++ +A G+ D
Sbjct: 59 DVVITMLPTGEVVRRCYTD---VLAAARPATLFIDSSTISVTDAREVHALAESHGMLQLD 115
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGGV GA ATLAFM GG + R+ P+L+ M K HCG G+GQ AK+ NNM++
Sbjct: 116 APVSGGVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVL 175
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ +A AE + K+GL + L DV+ ++ W+ CPVPG VPT+P++ ++ G
Sbjct: 176 AVQQIAIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPG 235
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F LM KDL LA + PLG+ A +Y + + DFS V
Sbjct: 236 FSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKF-AADHADLDFSAV 284
>UniRef50_A0C2T7 Cluster: Chromosome undetermined scaffold_145,
whole genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_145,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 299
Score = 165 bits (401), Expect = 9e-40
Identities = 86/230 (37%), Positives = 137/230 (59%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D ++++L ++K+V V + +KK +LIDSSTI P ++ +A + + D
Sbjct: 68 DTIITMLPNDKIVKSV---AQEIFKKSKK--ILIDSSTISPYTSYELAKMAQDTQNIYAD 122
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG V A+ T+ FM G KE +E+ P+LK MG F+CG+IG GQ+AK+ NM +
Sbjct: 123 APVSGSVSEAKLGTITFMVGAEKELYEKISPILKEMGKNIFNCGKIGEGQIAKMCGNMAL 182
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
I ++ E + +G MG++P +L +++ SS+R W+ + Y P PG++P PS+++YDGG
Sbjct: 183 AIQMISVCEALALGKNMGMDPAMLSSIMSVSSSRCWTVDTYNPAPGVMPNVPSNKDYDGG 242
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F ELM+KDL + + + LG A Q+Y + G+KDF+ V
Sbjct: 243 FMVELMLKDLGIGIEASRLSGTDTQLGQHAYQIYNKLNEH-LGKKDFAIV 291
>UniRef50_A6NVP0 Cluster: Putative uncharacterized protein; n=1;
Bacteroides capillosus ATCC 29799|Rep: Putative
uncharacterized protein - Bacteroides capillosus ATCC
29799
Length = 306
Score = 160 bits (388), Expect = 3e-38
Identities = 82/231 (35%), Positives = 132/231 (57%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VDV++ L + K+V GK+GV + K+G+++ID S++ PN K + A EKG+ +
Sbjct: 62 VDVIICSLPNAKIVEGTMCGKNGVFENCKEGTVIIDMSSVAPNTTKAMAKKAAEKGIHYI 121
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPVSGGV GA TL M G E F + P+ V+G +H G+ G G K+ NN+L
Sbjct: 122 DAPVSGGVSGAAAGTLTIMVGADDETFNKVKPIFDVLGKNIYHVGEAGGGDAIKMVNNLL 181
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+G A AE + +G+K GL + + +V++ SS RS++ + + + ++G
Sbjct: 182 LGCNMAALAEALTLGVKCGLSVETMKEVISVSSGRSYALD------AKLEKFIMAGQFNG 235
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
GF +L KDL LA + + P+P+ A A Q+Y + +++G G++D S V
Sbjct: 236 GFAVDLQYKDLGLALEASRDEKVPLPMTAAAVQVYEMARAKGQGREDMSSV 286
>UniRef50_A3I4V2 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Bacillus sp. B14905|Rep: 3-hydroxyisobutyrate
dehydrogenase - Bacillus sp. B14905
Length = 316
Score = 154 bits (373), Expect = 2e-36
Identities = 86/229 (37%), Positives = 133/229 (58%), Gaps = 1/229 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV++ L + ++V VYL ++G++ HAKKG+LL+D ST++P++ + A GL +
Sbjct: 79 DVVMTSLPTPQIVEMVYLSEEGIIHHAKKGALLVDFSTVNPDLNDSLHKEASTLGLRYLG 138
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGS-GQVAKLTNNML 335
APVSGGV+GA NATL M GG K+D++ + + ++G +H G S G KL NN++
Sbjct: 139 APVSGGVIGAVNATLTIMVGGGKDDYDSASEIFGIVGKNIYHLGLSSSVGTRLKLLNNLM 198
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+G A AE + +G KMG++ L +VL+NS +S +Y + NY
Sbjct: 199 IGFYTEAVAETIVLGEKMGIDADTLYEVLSNSYGQS---RIY---ERNYVEYMKNNNYAP 252
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
GF L++KDL+LA GMA + +G +LY + +GYG+ D S
Sbjct: 253 GFSTNLLLKDLKLAKGMADEAGVSLRIGEKLVELYSEIAQQGYGENDMS 301
>UniRef50_Q6C351 Cluster: Yarrowia lipolytica chromosome F of strain
CLIB122 of Yarrowia lipolytica; n=1; Yarrowia
lipolytica|Rep: Yarrowia lipolytica chromosome F of
strain CLIB122 of Yarrowia lipolytica - Yarrowia
lipolytica (Candida lipolytica)
Length = 334
Score = 152 bits (369), Expect = 7e-36
Identities = 91/236 (38%), Positives = 131/236 (55%), Gaps = 6/236 (2%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEK--GLGF 518
DV+ ++L V VY + K + +D STID + + +K F
Sbjct: 91 DVIFTMLPEPVHVRGVYTDLVNNLGD-KTSKIFVDCSTIDTQTSIECGKLVTDKDASAAF 149
Query: 517 TDAPVSGGVMGAQNATLAFMAGGRKED---FERSLPLLKVMGAKQFHCGQIGSGQVAKLT 347
DAPVSGGV+GA+ TL FM G K+ +++ LLK+MG + +CG G G AKL
Sbjct: 150 VDAPVSGGVVGAEKGTLTFMVGCNKDKQQVYKQVEELLKLMGGRIVNCGTQGQGLAAKLA 209
Query: 346 NNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSR 167
NN L+ +T +ATAE ++ K+G + K+ D++N+SS RSWS+EV PVPG+ P PSSR
Sbjct: 210 NNYLLAVTNVATAEAFHLAEKLGCDLKLFSDIVNSSSGRSWSSEVNNPVPGVNPATPSSR 269
Query: 166 NYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYR-IVQSRGYGQKDFSFV 2
+Y GGF LM KDL LA +A S + + ++Y+ I + Y KD S +
Sbjct: 270 DYVGGFGINLMRKDLGLAIDVAKQSGSSMLVADKTYEVYQNIEKGDNYQGKDMSVI 325
>UniRef50_A1QPH6 Cluster: 3-hydroxyisobutyrate dehydrogenase mmsB;
n=5; Mycobacterium|Rep: 3-hydroxyisobutyrate
dehydrogenase mmsB - Mycobacterium tuberculosis (strain
F11)
Length = 315
Score = 151 bits (365), Expect = 2e-35
Identities = 76/186 (40%), Positives = 111/186 (59%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV+++L + +VV Y V+A A+ +L IDSSTI +++ +A G+ D
Sbjct: 59 DVVITMLPTGEVVRRCYTD---VLAAARPATLFIDSSTISVTDAREVHALAESHGMLQLD 115
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGGV GA ATLAFM GG + R+ P+L+ M K HCG G+GQ AK+ NNM++
Sbjct: 116 APVSGGVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVL 175
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ +A AE + K+GL + L DV+ ++ W+ CPVPG VPT+P++ ++ G
Sbjct: 176 AVQQIAIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPG 235
Query: 151 FKNELM 134
F LM
Sbjct: 236 FSTALM 241
>UniRef50_Q0QLF5 Cluster: 2-hydroxymethyl glutarate dehydrogenase;
n=1; Eubacterium barkeri|Rep: 2-hydroxymethyl glutarate
dehydrogenase - Eubacterium barkeri (Clostridium
barkeri)
Length = 301
Score = 149 bits (360), Expect = 8e-35
Identities = 77/230 (33%), Positives = 131/230 (56%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D++ + L + +V V G GV++ K G++++D S++ P+ ++ +A EKG+ + D
Sbjct: 62 DIIFTSLPNAGIVETVMNGPGGVLSACKAGTVIVDMSSVSPSSTLKMAKVAAEKGIDYVD 121
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG GA+ TL M G + FE+ P+L V+G +H G G+G K+ NN+L+
Sbjct: 122 APVSGGTKGAEAGTLTIMVGASEAVFEKIQPVLSVIGKDIYHVGDTGAGDAVKIVNNLLL 181
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G + AE + +G+K GL+P+ + +++ SS RS++ E + S ++ GG
Sbjct: 182 GCNMASLAEALVLGVKCGLKPETMQEIIGKSSGRSYAME------AKMEKFIMSGDFAGG 235
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F +L KDL LA P+P+ A+ATQ++ ++ G G++D S V
Sbjct: 236 FAMDLQHKDLGLALEAGKEGNVPLPMTAMATQIFEGGRAMGLGREDMSAV 285
>UniRef50_A0JUJ6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Micrococcineae|Rep: 3-hydroxyisobutyrate dehydrogenase -
Arthrobacter sp. (strain FB24)
Length = 300
Score = 148 bits (358), Expect = 1e-34
Identities = 83/230 (36%), Positives = 126/230 (54%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV ++L + VYLG+DGV+AHA + +LL+DSSTID + + A G F D
Sbjct: 59 DVVFTMLPKGEHARAVYLGEDGVLAHADRRTLLVDSSTIDIASAQALHDAAAAAGFRFVD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG+ GA+ TL FM GG + ++ M + G +GQ AK+ NN+++
Sbjct: 119 APVSGGMSGAKAGTLTFMIGGDAGAVAEATEYIRPMASNIIPTGGPTTGQAAKICNNLML 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
I +TAE + ++GL+ +V D+ + SS SW+ + PV G+VPTA S+ ++
Sbjct: 179 FINLASTAEGAVLAERLGLDKQVFWDIASVSSGDSWALRTWYPVGGVVPTAASNNDFAPT 238
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F EL KD+ LA A +P+ +G L++ + G KD S +
Sbjct: 239 FTTELANKDIGLAISAARDTGTPLEIGEHVQTLFQRLIDSGQSGKDCSMI 288
>UniRef50_UPI00015B4162 Cluster: PREDICTED: similar to MGC108315
protein; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to MGC108315 protein - Nasonia vitripennis
Length = 276
Score = 147 bits (357), Expect = 2e-34
Identities = 66/132 (50%), Positives = 92/132 (69%)
Frame = -3
Query: 397 KQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWST 218
K HCG G GQVAK+ NNML+ I+ + +E +++G K+GL+PK+L D++N S+ R WS+
Sbjct: 134 KAVHCGDTGMGQVAKICNNMLLAISMIGVSEALSLGEKLGLDPKILTDIVNTSTGRCWSS 193
Query: 217 EVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQ 38
EV PVPG+ PT PSS +Y GGF L+ KDL LA A +SPI LG+++ Q+YR ++
Sbjct: 194 EVNNPVPGISPTVPSSNDYAGGFGTSLIAKDLGLAQAAATRAKSPIALGSLSHQIYRTME 253
Query: 37 SRGYGQKDFSFV 2
+ G G KDFS V
Sbjct: 254 AHGLGGKDFSVV 265
Score = 64.1 bits (149), Expect = 3e-09
Identities = 27/51 (52%), Positives = 40/51 (78%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIA 539
+V+V++L N+ VLD Y GKDG+++ AKKG+ L+DSSTIDP+V + +F A
Sbjct: 82 EVIVTMLPMNQHVLDTYTGKDGIISSAKKGTFLVDSSTIDPSVSQTVFKAA 132
>UniRef50_Q4PCH4 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 366
Score = 147 bits (356), Expect = 3e-34
Identities = 88/237 (37%), Positives = 128/237 (54%), Gaps = 11/237 (4%)
Frame = -3
Query: 685 VVSILTSNKVVLD-VYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQ----IFPIALEKGLG 521
V S+ T +LD + + V A+ +L ID +T+DP+V Q I
Sbjct: 108 VESVYTHENGILDGLESFQAAAVDDAQAKTLCIDCTTLDPDVAVQTATAIKNANANGAFD 167
Query: 520 FTDAPVSGGVMGAQNATLAFMAGGRKED-FERSLPLLKVMGAKQFHCGQIGSGQVAKLTN 344
DAPVSGGV+GA ATL+FM G F + P L +MG++ HCG+ G+G +AK+ N
Sbjct: 168 MIDAPVSGGVVGANAATLSFMVGSDSSTTFASAEPYLSLMGSRAVHCGKNGNGLIAKIAN 227
Query: 343 NMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVP----TAP 176
N+L+GI+ + E M +G GL P VL ++N S+ + WS+EV P PG + + P
Sbjct: 228 NLLLGISMLGVTEAMLLGTAHGLPPAVLAGIINTSTGKCWSSEVNNPCPGALEGTKYSPP 287
Query: 175 SSRNYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRG-YGQKDFS 8
+ R+Y GGF LM KDL+LA A P PLG + + +Y + + KDF+
Sbjct: 288 ADRDYQGGFAARLMAKDLKLAMNTAKLQGVPTPLGQLTSSIYEALGGNDEFKDKDFA 344
>UniRef50_A0GVR3 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Burkholderia phytofirmans PsJN|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Burkholderia phytofirmans PsJN
Length = 311
Score = 147 bits (355), Expect = 3e-34
Identities = 78/217 (35%), Positives = 120/217 (55%), Gaps = 1/217 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V+++L + V L VY G G+ + +LL++ ST+D +++ A G D
Sbjct: 58 DIVITMLPTPDVSLSVYEGAGGLFSITPPETLLLECSTVDVKTIERLGEGARASGTQLID 117
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
AP++GG+ GA ATL FM GG +E E + P L+ MG++ H G+ GSG KL NNM+
Sbjct: 118 APLTGGIEGAALATLTFMVGGSEEQLEYARPALQSMGSRIVHAGRFGSGTKLKLVNNMIC 177
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD-G 155
M +E + +G+K+GL+ + + DV+ N + SW Y P+PG+V APSSR +
Sbjct: 178 ATNLMVASEALTLGLKLGLDAQPMYDVIANGTGASWVLNTYYPLPGVVDGAPSSRGFRMP 237
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRI 44
F M KD+ A A + + PL VA L ++
Sbjct: 238 TFPATGMAKDMRCALEAARSVEAVTPLHNVAESLLKL 274
>UniRef50_Q1V2R0 Cluster: MmsB-like protein; n=2; Candidatus
Pelagibacter ubique|Rep: MmsB-like protein - Candidatus
Pelagibacter ubique HTCC1002
Length = 308
Score = 144 bits (349), Expect = 2e-33
Identities = 77/226 (34%), Positives = 120/226 (53%)
Frame = -3
Query: 685 VVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 506
V+S+L K V +YLG G++ K L+ID STID ++ + + G+ DAP
Sbjct: 62 VISMLPEGKHVRSLYLGDKGILNKIPKECLIIDCSTIDIETSLELGNESKKLGIKMIDAP 121
Query: 505 VSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGI 326
V+GGVMGA+ L F+ GG E + PL +MG K H G GSG K+ NNM +GI
Sbjct: 122 VTGGVMGARIGKLNFLVGGSDEAVALAKPLFDIMGQKILHAGVQGSGVGVKICNNMSLGI 181
Query: 325 TGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFK 146
+ +A +E + + ++ ++ K + +++ +S +W+ Y P+P L PS+ Y GF
Sbjct: 182 SMIAASESLMLAKRLKMDIKKVHEIIKAASGNNWAMTNYTPLPNLTDGVPSNNKYRPGFT 241
Query: 145 NELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
+M KDL LA A + + PLG A +++ G D+S
Sbjct: 242 ASMMRKDLRLAMDAAQSVDASTPLGKAALEIFSKFCDEGDSDTDYS 287
>UniRef50_Q4ZQL5 Cluster: 3-hydroxyisobutyrate dehydrogenase
precursor; n=11; Proteobacteria|Rep:
3-hydroxyisobutyrate dehydrogenase precursor -
Pseudomonas syringae pv. syringae (strain B728a)
Length = 296
Score = 141 bits (341), Expect = 2e-32
Identities = 78/228 (34%), Positives = 125/228 (54%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VD+++ L + V V LG G+ +KG +++D++T P + +++ + G+ F
Sbjct: 59 VDILILSLPKAEHVESVCLGAGGINEVGRKGLIVVDTTTSTPEMSRKVAAELAKNGIAFI 118
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPVSGG GA +++ + G D R++P+L+ M + H GQ G+G VAK+ NNML
Sbjct: 119 DAPVSGGPKGAATGSMSMVIGAEDADLARAMPVLEGMSGTRVHVGQCGAGNVAKIANNML 178
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
++TAE + M + G++P+ LL LN S RS +T+V + PT ++ YD
Sbjct: 179 AACHLISTAEAVAMAARAGVDPEKLLQGLNAGSGRSGATQV------MFPTWVLNKAYDS 232
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDF 11
GF LM KD+ LAS +A + +PL V QL++ +DF
Sbjct: 233 GFTMGLMRKDVGLASDLADSLDMDLPLSRVVAQLWQASSETLADNEDF 280
>UniRef50_Q1AVA4 Cluster: 2-hydroxy-3-oxopropionate reductase; n=6;
Bacteria|Rep: 2-hydroxy-3-oxopropionate reductase -
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 309
Score = 140 bits (338), Expect = 4e-32
Identities = 81/228 (35%), Positives = 125/228 (54%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+++++L + V V G+ GV+ ++GSLLID STI P V +Q+ A E+G D
Sbjct: 73 DIIITMLPDSPDVESVVAGEGGVLEGMREGSLLIDMSTISPAVARQLAAKARERGASMLD 132
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG +GA+ TL+ M GG +EDF R+ PL +VMG H G G+GQ+ K N +++
Sbjct: 133 APVSGGDVGAREGTLSIMVGGSEEDFGRARPLFEVMGKTVTHVGPSGAGQIVKAANQIVV 192
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G+T A E + +G++ G+EP+ + +VL A + EV SR++ G
Sbjct: 193 GLTIEAVCEALVLGLRGGVEPQKIFEVLCGGLAANRVMEV-------KREKFLSRDFRPG 245
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
K KDL +A +P A+ QL+ ++++G G D S
Sbjct: 246 GKARFHRKDLGIALNTGREYGVALPAAALVEQLFGALEAKGRGDLDHS 293
>UniRef50_A1SIN3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-hydroxyisobutyrate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 308
Score = 138 bits (333), Expect = 2e-31
Identities = 78/221 (35%), Positives = 117/221 (52%), Gaps = 4/221 (1%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLG---KDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLG 521
DVV+++L + ++ V LG + GV+ + G+L+IDSS+ID + A G+
Sbjct: 59 DVVITMLPNGDILRQVLLGAGAESGVLNYLAPGALVIDSSSIDVANCLAVHESAASAGIA 118
Query: 520 FTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNN 341
F DAPVSGGV GA TL FM GG + R+ PL + MG K G +GQ K+ N
Sbjct: 119 FLDAPVSGGVGGAAAGTLTFMVGGDEAHVRRAWPLFEAMGKKVVRVGGPSTGQAVKMCNQ 178
Query: 340 MLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVP-TAPSSRN 164
M+ + +A AE ++ K+G+ PK+L +V+ +SS W+ CP P +V + +
Sbjct: 179 MIYASSLVAVAEAFSLADKLGVAPKMLFEVVTSSSGDCWAIRNSCPWPDVVEGGSAADEG 238
Query: 163 YDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIV 41
+ F + LM KDL LA+ A + P+PL Y V
Sbjct: 239 FAPRFSSRLMSKDLRLATSAASNVGQPLPLTGKTVTFYEKV 279
>UniRef50_Q0URA2 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 325
Score = 138 bits (333), Expect = 2e-31
Identities = 87/211 (41%), Positives = 117/211 (55%), Gaps = 14/211 (6%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKD-GVVAHAKKGS------LLIDSSTIDPN----VPKQIFP 545
D V+++L + V VYL G++A A+ S L+++ TI+ + V K
Sbjct: 71 DTVITMLPDSNAVKKVYLDPSTGILAGAEANSGTKSDKLIMECGTIETSTILEVAKATSS 130
Query: 544 IALEKGLGFTDAPVSGGVMGAQNATLAFMAGGR-KEDFERSLPLLKVMGAKQ--FHCGQI 374
+ L F DAPVSGG MGAQ+ TLAFMAG K F R L MG F CG I
Sbjct: 131 SKAAENLTFVDAPVSGGPMGAQDGTLAFMAGANNKAIFPRVKGYLSHMGKPDAIFLCGDI 190
Query: 373 GSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPG 194
G+G K+ NN L IT +A +E +N+G KMGL+ +L DV+N S + W T PVPG
Sbjct: 191 GAGTAFKVINNYLSAITSLAASEALNIGTKMGLDVALLTDVINVSGGQCWVTSKSNPVPG 250
Query: 193 LVPTAPSSRNYDGGFKNELMVKDLELASGMA 101
+ PSSR+Y+GGF+ EL K L + S +A
Sbjct: 251 VQANVPSSRDYEGGFRIELCRKVLGMGSELA 281
>UniRef50_Q55702 Cluster: Uncharacterized oxidoreductase slr0229;
n=4; Cyanobacteria|Rep: Uncharacterized oxidoreductase
slr0229 - Synechocystis sp. (strain PCC 6803)
Length = 290
Score = 136 bits (329), Expect = 5e-31
Identities = 79/221 (35%), Positives = 120/221 (54%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D++++ + K V + LG G+ +AK +L+ID STI ++ +GL F D
Sbjct: 63 DIILTCVGDEKDVQQLILGSGGIAEYAKPQALIIDCSTIGKTAAYELATNLKLQGLRFLD 122
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APV+GG +GA N TL M GG DFE +LP+LK +G K HCG GSGQ KL N +L
Sbjct: 123 APVTGGDVGAINGTLTIMVGGDISDFEEALPVLKSIGEKIVHCGPSGSGQAVKLCNQVLC 182
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
GI +A AE + + ++G+ P++++D + +A SW+ + L P S ++ G
Sbjct: 183 GIHAIAAAEAIQLSEQLGIAPELVIDTCGSGAAGSWA------LTNLAPKM-SEADFAPG 235
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRG 29
F + ++KDL L A P+P +A L+ VQ G
Sbjct: 236 FMVKHLLKDLRLVREAA--ENGPLPGVTLAESLFTSVQLLG 274
>UniRef50_Q8ES28 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=13;
Bacillaceae|Rep: 3-hydroxyisobutyrate dehydrogenase -
Oceanobacillus iheyensis
Length = 299
Score = 135 bits (327), Expect = 8e-31
Identities = 77/229 (33%), Positives = 125/229 (54%), Gaps = 1/229 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV+++ L SNK V VYL K G++ H ++ID+ST+ P + +Q+ E+ + F
Sbjct: 59 DVILTSLPSNKAVEAVYLNKGGLLDHCNSSQVVIDTSTVAPELNQQLEASLSERSIPFLA 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCG-QIGSGQVAKLTNNML 335
APVSGGV+GA+N TL M GG++E F++ +L V+G FH G QI G KL NN+L
Sbjct: 119 APVSGGVVGAENQTLTVMVGGKEETFQKVKDILNVIGGNVFHVGEQIDKGTTVKLINNLL 178
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+G +E + + + ++ L ++N S +S +Y T +++
Sbjct: 179 IGFYTAGVSEALQIANQKDIDLNDLFSMMNVSYGQS---RIY---ERNYKTFIEPNDFNP 232
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
GF +L+ KDLE A +A + +P+ LYR ++ +GYG +D +
Sbjct: 233 GFALKLLRKDLEFAMEVADNNQLDLPISKSLLDLYRNLEHQGYGDQDMA 281
>UniRef50_A3H5R1 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Caldivirga maquilingensis IC-167|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Caldivirga maquilingensis IC-167
Length = 295
Score = 135 bits (327), Expect = 8e-31
Identities = 84/232 (36%), Positives = 130/232 (56%), Gaps = 1/232 (0%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VDVV+SI++ + V + LG++GV+ K+GSL+I+ STI P+ ++ EKG
Sbjct: 59 VDVVLSIVSDDDAVKSIMLGENGVINGIKQGSLVIEMSTISPSTSIELANKIKEKGGLMV 118
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAP+ G + + + GG +E +ER+ ++K H G G G AKL NN L
Sbjct: 119 DAPIIGTSILIEKREAVVLIGGEREAYERAYEVVKHFARYVVHVGPNGYGLYAKLINNAL 178
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNN-SSARSWSTEVYCPVPGLVPTAPSSRNYD 158
+G A AE +N+G MGL V++DVL SSARS ++E+ VP ++ + ++
Sbjct: 179 LGSYVAALAEVVNLGEAMGLSSSVIMDVLTKLSSARSPTSEL--KVPKMI-----NNDFT 231
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F + M KDL+L + A + P+P+ A+A QLYR+ ++ G DFS V
Sbjct: 232 TQFATKHMRKDLDLVNKEASRLGVPVPMAALALQLYRMSEADGLSDDDFSAV 283
>UniRef50_Q9K9L1 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Bacillus|Rep: 3-hydroxyisobutyrate dehydrogenase -
Bacillus halodurans
Length = 299
Score = 135 bits (326), Expect = 1e-30
Identities = 85/231 (36%), Positives = 121/231 (52%), Gaps = 1/231 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V++ L + V+DVY G+DG++A +G +LID ST+D ++ EKG F D
Sbjct: 60 DIVMTCLPLPETVIDVYEGEDGLIAGLSQGKILIDHSTVDRETNVRVAEQIKEKGGAFLD 119
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG MGA+ TL M GG + FERS +L G H G IGSG V KL NNM++
Sbjct: 120 APVSGGPMGAKAGTLTIMCGGEADSFERSKEVLGAYGDYIVHVGPIGSGTVVKLANNMVI 179
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G+ EC K G++P + +++ S+ S S E V ++ R +D
Sbjct: 180 GVHQAVLGECYLFVEKAGVDPAIAYEIIKRSAGFSKSME--WSVDAIL-----DRAFDPR 232
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRI-VQSRGYGQKDFSFV 2
F L+ KD+ LA + LG + IPL V R+ YG +D S +
Sbjct: 233 FSINLLHKDIGLA--LKLGEQLGIPLEMVEKGEERVRAAKEQYGHEDVSAI 281
>UniRef50_A0UF54 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Burkholderia multivorans ATCC
17616|Rep: 6-phosphogluconate dehydrogenase, NAD-binding
- Burkholderia multivorans ATCC 17616
Length = 289
Score = 133 bits (321), Expect = 5e-30
Identities = 74/215 (34%), Positives = 115/215 (53%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VDV++ L ++ +V V LG GV +HAK+G ++ID++T DPN +++ G+GF
Sbjct: 58 VDVLILSLPTSAIVEAVVLGDGGVASHAKRGLIVIDTTTADPNSTRKVAAALDAHGIGFI 117
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
D PVSGG GA AT+ + GG E P+L + AKQ H G G+G V KL NN+L
Sbjct: 118 DGPVSGGPKGAATATMTMVLGGADEHIAAVQPVLSAISAKQVHVGPAGAGHVTKLLNNLL 177
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
G+ + T+E + G++ L++ L+ S R+ +T PT + +D
Sbjct: 178 TGVHLLVTSEAVRAAEAAGVDKARLIEALSGGSGRNSATLTN------YPTWILNERFDS 231
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLY 50
GF +LM KD+ LA + P+ + A +L+
Sbjct: 232 GFTMKLMRKDMRLALELLQRAHVSAPIASEAGRLW 266
>UniRef50_O34948 Cluster: Uncharacterized oxidoreductase ykwC; n=19;
cellular organisms|Rep: Uncharacterized oxidoreductase
ykwC - Bacillus subtilis
Length = 288
Score = 133 bits (321), Expect = 5e-30
Identities = 79/221 (35%), Positives = 122/221 (55%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV+++++ V +VY G +G++ +AK+G+ LID +T P++ K+I A EK L D
Sbjct: 60 DVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSLAKKIAEAAKEKALFALD 119
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG +GAQN TLA M GG KE FE +P+ +MG + G GSGQ K+ N + +
Sbjct: 120 APVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQYQGPAGSGQHTKMCNQIAI 179
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ AE M K GLEP+ +L + +A SWS + L P N++ G
Sbjct: 180 AAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWS------LSNLAPRMLQG-NFEPG 232
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRG 29
F + +KD+ +A A + +P ++A LY + ++G
Sbjct: 233 FYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQG 273
>UniRef50_P0ABQ3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=25;
Bacteria|Rep: 2-hydroxy-3-oxopropionate reductase -
Escherichia coli O6
Length = 294
Score = 132 bits (319), Expect = 8e-30
Identities = 72/228 (31%), Positives = 123/228 (53%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV++++L ++ V +V LG++G++ AK G++LID S+I P ++I KG+ D
Sbjct: 58 DVIITMLPNSPHVKEVALGENGIIEGAKPGTVLIDMSSIAPLASREISEALKAKGIDMLD 117
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG A + TL+ M GG K F++ L+K M H G+IG+G V KL N +++
Sbjct: 118 APVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLMKAMAGSVVHTGEIGAGNVTKLANQVIV 177
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ A +E + + K G+ P ++ + A S + P+ RN+ G
Sbjct: 178 ALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPM-------VMDRNFKPG 230
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
F+ +L +KDL A + G+ + +PL A ++ + +++ G G D S
Sbjct: 231 FRIDLHIKDLANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHS 278
>UniRef50_Q0UVR9 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 288
Score = 131 bits (316), Expect = 2e-29
Identities = 79/199 (39%), Positives = 117/199 (58%), Gaps = 8/199 (4%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLG-KDGVVAHAK-KGSLLIDSSTIDPNVPKQIFPIALEKGLG-F 518
V++SI+ K V VYL K GV+A K +G L+++ STID K++ E+GLG +
Sbjct: 24 VLISIVPGGKDVKTVYLDEKTGVIAARKDEGRLMLECSTIDVESTKEVGRKLKEEGLGTY 83
Query: 517 TDAPVSGGVMGAQNATLAFMAGGRKEDFERSLP-LLKVMG--AKQFHCGQIGSGQVAKLT 347
DAPVSGGV A+ TL+ + G D LP L ++G +K F+ +G+G AK++
Sbjct: 84 IDAPVSGGVPAAEAGTLSMLIGAPPPDPTSLLPSTLSLLGTPSKFFYLHTLGAGLTAKIS 143
Query: 346 NNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPT--APS 173
NN L G +ATAE + +G+K GL+P L V+ NS+ +SW + P+P + PS
Sbjct: 144 NNYLSGTILLATAEALAIGVKHGLDPAALYSVIKNSTGQSWMCDHVLPIPNVQTEYWVPS 203
Query: 172 SRNYDGGFKNELMVKDLEL 116
+ Y GFK ++M+KDL L
Sbjct: 204 NSGYKPGFKTQMMLKDLGL 222
>UniRef50_A2SP40 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Methylibium petroleiphilum PM1|Rep: 3-hydroxyisobutyrate
dehydrogenase - Methylibium petroleiphilum (strain PM1)
Length = 297
Score = 130 bits (315), Expect = 2e-29
Identities = 85/232 (36%), Positives = 121/232 (52%), Gaps = 1/232 (0%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VDVVV+ L + +V DVYLGK G+VA A+ GS LI++STIDPN +++ A + G+
Sbjct: 58 VDVVVTSLPNPPIVRDVYLGKQGLVAQARPGSTLIETSTIDPNTIREVAQAATKSGIRIL 117
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
D +SG A L F GG E ++ L LL+V+ K G IG+ + KL NN L
Sbjct: 118 DIALSGEPPQAVLGELVFQVGGPDELIDQHLELLQVLAKKINRTGGIGTAKTVKLVNN-L 176
Query: 334 MGITGMA-TAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD 158
M + +A AE +G+K G+EPK L ++L+ S RS + G +Y
Sbjct: 177 MSLGNVAVAAEAFVLGVKCGMEPKRLYEILSVSGGRSAHF-----ISGFQKVIEG--DYG 229
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
FK L +KD+ L +A L V LYR RG G+++F+ V
Sbjct: 230 ASFKTSLALKDINLILDLANEEHYAARLAPVIASLYRDAVGRGLGEENFTSV 281
>UniRef50_A5V0D4 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=4; Chloroflexaceae|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Roseiflexus sp. RS-1
Length = 303
Score = 130 bits (314), Expect = 3e-29
Identities = 80/225 (35%), Positives = 120/225 (53%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D++++ ++ V V LG+ GV+ A+ GSL+ID STI P ++I E+ + D
Sbjct: 62 DIIITCVSDTPDVEQVLLGEGGVIHGARPGSLVIDMSTISPRATQRIAAHLAERHIHMLD 121
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG GA TL+ M GG FER+LP+ + MG H G IG+GQ KL N +L+
Sbjct: 122 APVSGGSEGAARGTLSIMVGGDVTQFERALPVFQAMGTTITHLGPIGAGQTTKLVNQILV 181
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+A +E + G++ + L+ ++ +A SW P LV R++ G
Sbjct: 182 VGHALAMSEALLFAQAGGVDLRKALEAVSGGAAGSWMLSNRGP-QILV------RDWRPG 234
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQK 17
F +L KDL L A + P+P A+ QLYR +Q+RG G +
Sbjct: 235 FTIDLQQKDLRLVLQEADRLGVPLPGTALIHQLYRTLQARGLGHE 279
>UniRef50_A2U9T6 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Bacillaceae|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Bacillus coagulans 36D1
Length = 294
Score = 130 bits (314), Expect = 3e-29
Identities = 78/230 (33%), Positives = 122/230 (53%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV+V++LT+ V +V G+DGV+A KG ++D ST+ P+ + EK F D
Sbjct: 63 DVIVTMLTNAAAVENVLQGEDGVLAGLTKGKTVVDMSTVSPSDSIRFAKWVEEKRGHFID 122
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG V A+ L +AGGRKE+ + P+ +V+G H G+ G G AKL+ N+L+
Sbjct: 123 APVSGSVQPAKEGNLVILAGGRKEEIDAVRPMFEVLGKTIIHFGENGKGSAAKLSINLLL 182
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G+T +E + G K+GLE K L+++++ S+ + P+ + A ++
Sbjct: 183 GLTIEGASEAILFGEKLGLEKKDLIEMISASACNT-------PIFQMKKKAFLQEDFPAA 235
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F ELM KDL LA +PL A + Y ++ G G+ D + V
Sbjct: 236 FMLELMAKDLGLAKEEIKKAGMSLPLADAAEKTYSRAKADGTGKADVAAV 285
>UniRef50_Q0C8I2 Cluster: Predicted protein; n=3;
Pezizomycotina|Rep: Predicted protein - Aspergillus
terreus (strain NIH 2624)
Length = 320
Score = 130 bits (314), Expect = 3e-29
Identities = 82/219 (37%), Positives = 120/219 (54%), Gaps = 7/219 (3%)
Frame = -3
Query: 685 VVSILTSNKVVLDVYLGKD-GVVAHAKKGSLLIDSSTIDP--NVPKQIFPIALEKGLGFT 515
+++++ V VYL + GV + LLID STID ++ + F
Sbjct: 72 IITMVPEGSHVRAVYLDESTGVCSTPLDTRLLIDCSTIDTATSLAVKAHITTHHASASFY 131
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLL----KVMGAKQFHCGQIGSGQVAKLT 347
DAPVSGGV+GAQ +AF G K D +LPLL ++MG + CG G AKL
Sbjct: 132 DAPVSGGVLGAQKGAIAFFLGCAKTD--PNLPLLTDTLRLMGKEVIPCGGPSLGLSAKLC 189
Query: 346 NNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSR 167
NN L G+ +A +E +N+G++ GL+P+VL V +A++ + + P PG+VP APSS+
Sbjct: 190 NNYLSGLIAIANSEALNIGMRAGLDPRVLSSVFAAGTAQNAICDRFNPCPGVVPDAPSSK 249
Query: 166 NYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLY 50
+Y GFK +LM KD LA MA + + + LG + Y
Sbjct: 250 DYRTGFKIQLMRKDFALAVAMAEQVGARLVLGEAGLKTY 288
>UniRef50_Q67QX0 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Symbiobacterium thermophilum|Rep: 3-hydroxyisobutyrate
dehydrogenase - Symbiobacterium thermophilum
Length = 294
Score = 130 bits (313), Expect = 4e-29
Identities = 76/200 (38%), Positives = 109/200 (54%)
Frame = -3
Query: 613 AKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDF 434
A+ G + +D STI K+I + EKG+ F DAPVSGG GA+ TL M GG + F
Sbjct: 83 AQPGDIFVDHSTIGVRDAKRIAAMCAEKGVQFIDAPVSGGPWGAEAGTLTIMCGGDRAAF 142
Query: 433 ERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLD 254
E LP L+V G H G +G+G VAKL NN+L+GI A AE +G K G++PK L +
Sbjct: 143 EAVLPYLQVEGKAIHHLGPVGAGSVAKLCNNLLVGIHTAAMAEAFVLGTKAGVDPKALYE 202
Query: 253 VLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIPL 74
+++N++ S ++ +P V P +D F + + KD+ LA + + L
Sbjct: 203 IISNATGH--SAQIARNIPQFV--FPG--KFDAAFSIDHLHKDVALAVELGKDENVRMVL 256
Query: 73 GAVATQLYRIVQSRGYGQKD 14
GAV QL ++ GYG D
Sbjct: 257 GAVTQQLLAEARALGYGGSD 276
>UniRef50_Q97XZ7 Cluster: Oxidoreductase; n=6; Thermoprotei|Rep:
Oxidoreductase - Sulfolobus solfataricus
Length = 289
Score = 128 bits (310), Expect = 1e-28
Identities = 72/224 (32%), Positives = 120/224 (53%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
++V+S++T V +V G++GVV K+G + +D ST P K++ E G+ F D
Sbjct: 58 EIVISMVTDAPDVEEVLFGENGVVKSNKRGLIFVDMSTNSPEFAKKVTKRLSEYGMEFLD 117
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APV+GG GA+ TL M GG+++ F+R P+ K MG H G +GSGQ KL N +++
Sbjct: 118 APVTGGDKGAREGTLTIMVGGKEDVFKRVEPIFKAMGKNIIHVGDVGSGQALKLCNQVVV 177
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ ++ E + + +G++ L VL+ +A S++ + Y P + + G
Sbjct: 178 ALNMVSVVEGLLLARSLGIDDDKLFSVLSTGAANSFTVQYYLP-------KIMKGDLNPG 230
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQ 20
FK + KDL+ A +A P+ ++A QLY + S G G+
Sbjct: 231 FKAAHLKKDLKYAMEIANSKSLPLLGTSLALQLYNAMVSLGIGE 274
>UniRef50_Q1QWU9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Chromohalobacter salexigens DSM 3043|Rep:
3-hydroxyisobutyrate dehydrogenase - Chromohalobacter
salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB13768)
Length = 310
Score = 127 bits (307), Expect = 2e-28
Identities = 77/206 (37%), Positives = 108/206 (52%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV + L ++ V +V G++ A KGS+++D+ST DP V +++ +E GL + D
Sbjct: 66 DVYLLSLPTSAHVREVIETSPGLLQRAPKGSVIVDTSTSDPAVTRELAGKVVEAGLEWLD 125
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG GA + L + GG ER P+L+ M A+ H G GSG V KL NN L
Sbjct: 126 APVSGGPAGAASGALGMLLGGESATIERLAPMLEAMSARHTHVGPAGSGHVVKLANNYLC 185
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ TAE + + + G++P L LN+ S RS +EV P L S +D G
Sbjct: 186 AAHLLTTAEAVTLAARAGVDPAACLAGLNSGSGRSAVSEVNFPKWIL------SDAFDSG 239
Query: 151 FKNELMVKDLELASGMALGIRSPIPL 74
F LM KDL LA A + P+ L
Sbjct: 240 FTTGLMRKDLRLARDAASNMGLPLEL 265
>UniRef50_Q41DK0 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Bacillaceae|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Exiguobacterium sibiricum
255-15
Length = 293
Score = 126 bits (304), Expect = 5e-28
Identities = 77/225 (34%), Positives = 120/225 (53%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VDVV+SI+ + V ++YL +DG++A A G+++ID +T P + +I A + GL
Sbjct: 59 VDVVISIVGYPQDVEEIYLAEDGILASANPGTIVIDMTTSSPALAIRIAEQAAQTGLHAL 118
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPV+GG +GA+N TLA + GG + F+ PL + MG G G GQ AKL N +
Sbjct: 119 DAPVTGGDLGAKNGTLAILVGGEEAAFDTVKPLFEAMGKSIARFGGPGQGQSAKLANQIA 178
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+ + + TAE + K G++P + + + SA SWS E L+P + NY
Sbjct: 179 IAGSMIGTAEMLLFVTKSGIDPTQFVATIKSGSAGSWSLE------NLIPRV-IAENYSP 231
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQ 20
GF + +KD+ LA A + P A+ LY + + G+ +
Sbjct: 232 GFFVKHFIKDMRLALERADEMGISTPGLALVKDLYEELAASGHAE 276
>UniRef50_A0LMG6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=9;
cellular organisms|Rep: 3-hydroxyisobutyrate
dehydrogenase - Syntrophobacter fumaroxidans (strain DSM
10017 / MPOB)
Length = 309
Score = 126 bits (304), Expect = 5e-28
Identities = 73/224 (32%), Positives = 127/224 (56%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV ++L + V +VY G++G++ A+ G +L+D +T +P++ ++I A E+G D
Sbjct: 71 DVVFTMLGFPQDVREVYFGRNGLLQAARPGIILVDMTTTEPSLAREIHQAAGEQGAFAVD 130
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG +GA+NA L+ M GG +E + P+L+ MG + G GSGQ AK+ N +++
Sbjct: 131 APVSGGDVGARNAALSIMLGGDREVVDAIRPILEAMGKNLVYLGPAGSGQHAKVCNQIVI 190
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
T + E + G K GL+ +L + + +A+ W+ + L P R++ G
Sbjct: 191 TGTMIGVCESLMYGFKAGLDLPTMLSSIKDGAAKCWTLD------NLAPRI-LRRDFAPG 243
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQ 20
F + +KD+ +A A + +P A+ QLY V+++G+G+
Sbjct: 244 FFVDHFIKDMGIALQEAARMGLSLPGLALTHQLYLAVKAQGHGK 287
>UniRef50_Q92D17 Cluster: Lin1004 protein; n=10; Bacilli|Rep:
Lin1004 protein - Listeria innocua
Length = 286
Score = 125 bits (302), Expect = 9e-28
Identities = 71/226 (31%), Positives = 123/226 (54%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VD+++S++ K V +YLG++G + + K GS+ ID +T P + K+I EKG+G
Sbjct: 58 VDILISMVGYPKDVEQLYLGENGFLDNLKAGSVAIDMTTSSPALAKKIAEAGHEKGIGVL 117
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPVSGG +GA+N TLA M GG ++ F + P+ +++G+ G GSGQ K+ N +
Sbjct: 118 DAPVSGGDIGAKNGTLAIMVGGAEDVFLKVKPIFEILGSSVILQGDAGSGQHTKMVNQIA 177
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+ + E + + GL P +LD ++ +A SWS + L+P ++
Sbjct: 178 IASNMIGVTEAIIYAERAGLNPSRVLDSISGGAAGSWS------LTNLIPRVLQD-DFSP 230
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQK 17
GF + +KD+ +A A + +P +A Q+Y+ + +G ++
Sbjct: 231 GFFIKHFIKDMGIALSEAKQMGLELPGLTLAEQMYQTLAEQGLSEE 276
>UniRef50_Q01ZG6 Cluster: 2-hydroxy-3-oxopropionate reductase; n=6;
Bacteria|Rep: 2-hydroxy-3-oxopropionate reductase -
Solibacter usitatus (strain Ellin6076)
Length = 298
Score = 125 bits (301), Expect = 1e-27
Identities = 76/229 (33%), Positives = 119/229 (51%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
+V+++L V LG GV+ AK G++++D S+I P V +++ KG+ F DA
Sbjct: 60 IVITMLPDGPEVETAVLGPGGVLEGAKAGTVVVDMSSISPMVSQKVAAACAAKGVEFLDA 119
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PVSGG A + TLA M GG+ E FER P+L MGA G +G+G V KL N +++
Sbjct: 120 PVSGGEPKAIDGTLAIMVGGKPEVFERVQPVLAKMGASVTLTGAVGAGNVTKLANQIMVA 179
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGF 149
A E + + K GL+P+V+ + + A ST + P ++ RN+ GF
Sbjct: 180 CNIAAMGEALVLATKAGLDPEVVFNAVKGGLA--GSTVLNAKAPMVI-----GRNFKPGF 232
Query: 148 KNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
+ L KDL A A ++ +P ++A Q+ + + G G D S +
Sbjct: 233 RINLHEKDLRNALQAAESMKVSLPFTSLAQQMLIALMNDGKGNLDHSAI 281
>UniRef50_Q8KL12 Cluster: Probable 6-phosphogluconate dehydrogenase
protein; n=1; Rhizobium etli CFN 42|Rep: Probable
6-phosphogluconate dehydrogenase protein - Rhizobium
etli (strain CFN 42 / ATCC 51251)
Length = 294
Score = 124 bits (300), Expect = 2e-27
Identities = 72/205 (35%), Positives = 112/205 (54%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV V++L + K+V D L KDG +L+ID S+ PN +++ +KGL D
Sbjct: 64 DVAVTMLPNGKIVQDA-LFKDGAWQSLSADALVIDMSSSAPNDTRELAERLHQKGLRLVD 122
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGGV A +L MAGG +D +++ P+L MG + F G IGSG K NN +
Sbjct: 123 APVSGGVKRAVEGSLTIMAGGASDDIDQADPILCAMGGQIFRTGPIGSGHAMKAINNFVS 182
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G +A E + +G GL+P+ ++D+LN+SS ++ +TEV + S + G
Sbjct: 183 GAGVLAAIEGVLLGRTFGLDPRTIVDILNSSSGKNNATEV------KMKQFILSETFGSG 236
Query: 151 FKNELMVKDLELASGMALGIRSPIP 77
F LM KD+ +A+ ++ + +P
Sbjct: 237 FALGLMAKDIRIAADLSKALNLQLP 261
>UniRef50_Q58PL4 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
uncultured proteobacterium DelRiverFos06H03|Rep:
3-hydroxyisobutyrate dehydrogenase - uncultured
proteobacterium DelRiverFos06H03
Length = 299
Score = 124 bits (300), Expect = 2e-27
Identities = 72/215 (33%), Positives = 116/215 (53%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV++ L V +V LG+ GV+AH K G+ +ID+ST + +++ +A KG+ F +
Sbjct: 63 DVVMASLPGPVQVREVMLGEQGVLAHVKAGATVIDTSTSAVELVQELVALAKSKGVDFLE 122
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APV+ V A L+ GG K+ FE+ P+ V+G K FH G+ G+G KL N+L
Sbjct: 123 APVTNAVDMAALGRLSIFVGGDKDCFEKHKPIFDVIGEKIFHVGEPGNGATIKLLTNLLW 182
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
++ A E + +G K G+ + + + +S+ SW E VP + + +YD
Sbjct: 183 FVSAAAIGEGLMLGAKAGIPLHTVWEAIKSSAGNSWVAE--HDVPSIF-----AGHYDPS 235
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYR 47
F L KDL L +G+A +P+G +A QL++
Sbjct: 236 FSLALCCKDLGLINGIAKSQGYDLPMGGMAQQLFQ 270
>UniRef50_Q4Q7T9 Cluster: 2-hydroxy-3-oxopropionate reductase,
putative; n=6; Trypanosomatidae|Rep:
2-hydroxy-3-oxopropionate reductase, putative -
Leishmania major
Length = 299
Score = 123 bits (297), Expect = 4e-27
Identities = 77/231 (33%), Positives = 120/231 (51%), Gaps = 1/231 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFP-IALEKGLGFT 515
DVV + L+ + V++V G +GV A +G++ +D+STI P+V ++I + EK +
Sbjct: 58 DVVFTNLSDSPDVMEVVFGPNGVAAGICEGAIFVDNSTIKPSVAQEIARRLWKEKKVRAL 117
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPVSGG +GA+N TL M GG LP+L +G K H G G+GQV K N ++
Sbjct: 118 DAPVSGGDIGARNGTLTVMVGGDAAALATVLPVLLAVGKKVTHIGDCGAGQVCKAANQIM 177
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+ +A E + K G+ +++ + + SA+ W+ +V P + N
Sbjct: 178 VAAQMVALGEILVFCEKCGVSGPTVIEAIKSGSAQCWTLDV-------KPDRLFAGNRAP 230
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
GFK L KD+ + A P+P AV TQL++ + G G +D S V
Sbjct: 231 GFKAALQSKDMGIVMDTAKEFGVPLPSTAVNTQLFQAMVQNGDGDRDNSAV 281
>UniRef50_Q01QM2 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Solibacter usitatus Ellin6076|Rep: 3-hydroxyisobutyrate
dehydrogenase - Solibacter usitatus (strain Ellin6076)
Length = 298
Score = 123 bits (296), Expect = 5e-27
Identities = 78/228 (34%), Positives = 120/228 (52%), Gaps = 2/228 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV + + +V LG G++ + G++++D STI ++I K + F D
Sbjct: 60 DVVFLCVGDTAMAREVILGGQGLIQGLRAGAVVVDCSTIAVADSREIGAALKAKSVDFLD 119
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APV+G GA++ L FM GG + F + PLL MG K + CG G G AKLT N+++
Sbjct: 120 APVTGSTPGAESGNLTFMIGGDEAVFSKIRPLLDPMGKKIYFCGGAGMGLQAKLTQNLVL 179
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
MA E M + K G++PK++L++L+NS+A+S P SRN+
Sbjct: 180 SNILMAFNEGMVLATKGGMDPKLMLEILDNSAAKSGLISYKAPF-------VFSRNFTTN 232
Query: 151 FKNELMVKD--LELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
F + M KD L L SG LG+ P+ L + QL++ + G+G +D
Sbjct: 233 FSVKWMHKDIGLMLESGKDLGV--PLYLTGLTRQLFQTAIAAGHGDED 278
>UniRef50_Q4KH51 Cluster: 3-hydroxyisobutyrate dehydrogenase family
protein; n=16; Gammaproteobacteria|Rep:
3-hydroxyisobutyrate dehydrogenase family protein -
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Length = 298
Score = 122 bits (295), Expect = 6e-27
Identities = 70/227 (30%), Positives = 119/227 (52%), Gaps = 1/227 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFP-IALEKGLGFT 515
D+++ L + +VV +V G G+ A+ G LL+D S+++P +++ +A +G+ +
Sbjct: 63 DLMLMCLANTEVVREVVFGPQGIAQGARAGQLLLDLSSLEPTATREMAAELAASRGVAWV 122
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPVSGG GA+ +LA M GG D ER P+L +G + H G +G+GQV K N M+
Sbjct: 123 DAPVSGGTPGAEAGSLAIMVGGEATDVERVRPVLLTLGQRVTHMGAVGAGQVTKACNQMI 182
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+ + AE + + + G++ +++ + L A S P+ L P SR
Sbjct: 183 VACNALVIAEVVALAERSGVDARLIAEALAGGFADS------KPLQILAPQMAESRFEPV 236
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
+ ++KDL+ A + S P+ +A QL R+ +GY +KD
Sbjct: 237 KWHVRTLLKDLDGAVKFSREQGSATPISGLAAQLMRLHGGQGYLEKD 283
>UniRef50_Q4FMJ3 Cluster: 6-phosphogluconate dehydrogenase; n=2;
Candidatus Pelagibacter ubique|Rep: 6-phosphogluconate
dehydrogenase - Pelagibacter ubique
Length = 289
Score = 122 bits (294), Expect = 8e-27
Identities = 67/228 (29%), Positives = 124/228 (54%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV++++LT + V V +G D +++ K+G+ +ID S+++P + K+ F I EK + + D
Sbjct: 59 DVIITMLTDDAAVEKV-MGSDEFISNIKEGATVIDMSSVNPVITKKYFKILKEKNINYLD 117
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG +GA+ A+LA M GG +E F++ LLK++G G + SGQ++KL N +++
Sbjct: 118 APVSGGTIGAEEASLAIMVGGDEETFKQCYDLLKILGNPTL-VGPVTSGQISKLANQIIV 176
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G+T A AE + + K G P +++ L+ W+ G ++++
Sbjct: 177 GVTIGAVAEAVTLCEKSGTNPNKMIEALSG----GWADSKILQTHG---KRMINKDFTPK 229
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
K +KD+ + +P+ ++ ++Y+ + + G G D S
Sbjct: 230 GKTTTQLKDMTNIINAGKAAETHLPISSLVKEMYKDLVADGQGNTDHS 277
>UniRef50_Q18X68 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Desulfitobacterium hafniense|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Desulfitobacterium hafniense (strain DCB-2)
Length = 298
Score = 122 bits (294), Expect = 8e-27
Identities = 71/226 (31%), Positives = 122/226 (53%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D++ L +++VV V LG+ G+ + G +++D+STI+ + +I G+ F D
Sbjct: 57 DIIFCSLPNSEVVCQVVLGETGLKKVLRAGQIIVDTSTINYSTTLEIGKQLESVGVEFID 116
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG A+ TL M GG++E FE P L+ K + GQ GSGQ+ KL N +L
Sbjct: 117 APVSGMESRAKEGTLTTMCGGKQELFENVKPYLQCFADKILYMGQPGSGQLTKLINQLLF 176
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
I A AE + M +K+GL+P+ + V+N+ + RS+++E + P+ ++ G
Sbjct: 177 DINVAALAEILPMSVKLGLDPEKVGAVVNSGTGRSYASEFFIPM-------ILKGSFMDG 229
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
+ + KDL + ++ + P+P+ AT Y++ +G G +D
Sbjct: 230 YPMKHAYKDLVSGAEISASLCIPMPVLGAATTTYQMALLKGLGDRD 275
>UniRef50_Q11FC5 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Rhizobiales|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Mesorhizobium sp. (strain
BNC1)
Length = 292
Score = 122 bits (294), Expect = 8e-27
Identities = 78/223 (34%), Positives = 114/223 (51%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVVV++L V V LG+DG+ G+L+ID STI + + I +G+ D
Sbjct: 59 DVVVTMLPDTPHVQSVLLGEDGIGTLLPTGTLVIDMSTISASGIRAIGQDLASRGVDLVD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGGV GA L+ M GG E F ++ P+L+ MG H G +G GQV K+ N +++
Sbjct: 119 APVSGGVRGAIAGELSIMCGGSPEAFAKARPVLEGMGTTIIHAGDLGMGQVFKMCNQLMV 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G+ A E + G + +L + L +A SW E L P +++ G
Sbjct: 179 GVHIQAMCEAFALCRAQGGDLNLLRETLMGGAAGSWMLE------NLGPQV-IAKDDSAG 231
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYG 23
F+ +L +KDL LA A P+P A+AT LY ++ G G
Sbjct: 232 FRIDLQLKDLRLAGEAAFEKGLPLPGLAMATSLYLEARAHGEG 274
>UniRef50_Q930C6 Cluster: Probable; n=8; Alphaproteobacteria|Rep:
Probable - Rhizobium meliloti (Sinorhizobium meliloti)
Length = 295
Score = 121 bits (291), Expect = 2e-26
Identities = 73/226 (32%), Positives = 118/226 (52%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D V+ L + +V G GV A A+ G+L+ID S+IDPN KQ+ A EKGL + D
Sbjct: 60 DYVILSLNAPAIVRQAVFGDAGVAAGAQAGTLIIDMSSIDPNATKQLAADAAEKGLRWVD 119
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
+P+SGG A L MAGG +D + + +L+ + + H G +G+GQ KL N +L
Sbjct: 120 SPLSGGAPKALIGELTLMAGGTAQDVKDAHAVLRHVASNYTHMGSVGAGQTTKLINQVLC 179
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G+ +A AE + + G++ + L A S + Y +P V +++Y
Sbjct: 180 GLGFLAVAEATQLALDAGVDASKIPQALMGGRADSAILQEY--MPRFV-----TKDYRHT 232
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
+ + MVKDL A +A + +PL A +++R++ + G G +D
Sbjct: 233 GRIDNMVKDLAGAQDLARRTNTAMPLTAACAEIHRMLTAAGLGGED 278
>UniRef50_Q13LQ9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=11;
Proteobacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Burkholderia xenovorans (strain LB400)
Length = 296
Score = 120 bits (290), Expect = 3e-26
Identities = 70/218 (32%), Positives = 113/218 (51%), Gaps = 3/218 (1%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLG---KDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGL 524
+D ++++L ++ +V V LG G A KG+++ID S+ +P + + + L
Sbjct: 60 LDALITMLPNSAIVEAVVLGDGNNTGWAARLAKGAVVIDMSSSEPERSRALGKTLEAQRL 119
Query: 523 GFTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTN 344
+ DAPVSGGV A+ TLA + GG + R PLL MG H G G+G AK N
Sbjct: 120 AYLDAPVSGGVKRAKEGTLAILVGGHADVLARCKPLLDAMGTNVLHIGTAGAGHAAKALN 179
Query: 343 NMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRN 164
N + + AT E + + + G++P+V+ DVLN S+ RS ++E S
Sbjct: 180 NYVSAASVAATVEALQIASRFGIDPQVMTDVLNASTGRSNTSE------NKAKQFMLSGT 233
Query: 163 YDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLY 50
+ GF +LM KDL++A +A + P+ GA +++
Sbjct: 234 FASGFALQLMNKDLKIARALAQAVGHPMTFGATCVEVW 271
>UniRef50_Q0SBQ9 Cluster: 2-hydroxy-3-oxopropionate reductase; n=12;
Actinomycetales|Rep: 2-hydroxy-3-oxopropionate reductase
- Rhodococcus sp. (strain RHA1)
Length = 294
Score = 120 bits (289), Expect = 3e-26
Identities = 79/228 (34%), Positives = 110/228 (48%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV ++ + V V G+DGV H G+L+ID S+I P+V + A E+G D
Sbjct: 59 DVVAVMVPDSPDVQAVLTGEDGVFEHTPSGALIIDFSSIRPDVTTALAAQATERGFRLID 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG GA NA L+ M GG EDFE + P+L V+G H G GSGQ K N +++
Sbjct: 119 APVSGGEAGAVNAALSIMVGGAPEDFESARPILDVVGKTVVHVGPNGSGQTVKAANQLIV 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
AE + G++ ++VL A S V R+++ G
Sbjct: 179 AGNIQLLAEAIIFLEAYGVDTAAAVEVLGGGLAGS-------AVLNQKAQKMLDRSFEPG 231
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
F+ +L KDL + + A PLGAV QL ++ G G D S
Sbjct: 232 FRIDLHHKDLGIVTSAAREAGVVTPLGAVLAQLMASARANGDGGLDHS 279
>UniRef50_A1UP64 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Mycobacterium|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Mycobacterium sp. (strain
KMS)
Length = 305
Score = 120 bits (288), Expect = 4e-26
Identities = 77/228 (33%), Positives = 112/228 (49%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV+++L + V +V G GV + GSL+ID STI P+ I EK + F D
Sbjct: 58 DVVITMLPDSPEVEEVLFGPAGVTTTLRPGSLVIDCSTISPDAAVAIGARLAEKDIAFVD 117
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG GA LA M GG ++ R+ +L + A H G +G+GQ+ K N ML+
Sbjct: 118 APVSGGEAGAIAGALAVMMGGDEDAVRRAATVLDAVAATSVHVGPVGAGQLVKAANQMLV 177
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
E + + + G++ L VL A S E P +R++ G
Sbjct: 178 AGNIALVGEAVTLLQRTGVDVDAALAVLGGGLAASKVLEAKAP-------KMLARDFAPG 230
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
F+ +L KDL++A A R +PL + TQL + ++S G G D S
Sbjct: 231 FRIDLHYKDLKIALAAAEQARIAVPLTGIITQLVQALRSAGDGGLDHS 278
>UniRef50_Q1GJB9 Cluster: 6-phosphogluconate dehydrogenase
NAD-binding; n=1; Silicibacter sp. TM1040|Rep:
6-phosphogluconate dehydrogenase NAD-binding -
Silicibacter sp. (strain TM1040)
Length = 304
Score = 118 bits (285), Expect = 1e-25
Identities = 76/227 (33%), Positives = 118/227 (51%), Gaps = 1/227 (0%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKD-GVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
+V+S+ T+ V+ V + G +A +++D+ST + + + G GF D
Sbjct: 66 IVLSLPTAQHVLAVVQAAQAAGHLAQTGAARVIVDTSTSEAATSRTLAAELSALGHGFLD 125
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG GA + L+ M GG + E + P L+ M AK H G G+G VAKL NNML+
Sbjct: 126 APVSGGPAGAASGQLSVMLGGETQWLEAARPALEAMAAKILHVGPSGAGNVAKLVNNMLV 185
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ T E + +G G+ K +L+V+N+++ RS +EV+ P ++P R++D G
Sbjct: 186 ANHMVTTLEALRLGEAAGVAAKEMLEVVNSATGRSAISEVHYP-NWVLP-----RSFDSG 239
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDF 11
F LM KDL LA +A + P+ +L+ QS DF
Sbjct: 240 FSAGLMRKDLRLARALAAEVSVATPMADRVAELWAETQSGLSDSDDF 286
>UniRef50_Q0LNZ7 Cluster: 3-hydroxyisobutyrate dehydrogenase
precursor; n=1; Herpetosiphon aurantiacus ATCC
23779|Rep: 3-hydroxyisobutyrate dehydrogenase precursor
- Herpetosiphon aurantiacus ATCC 23779
Length = 301
Score = 118 bits (285), Expect = 1e-25
Identities = 71/214 (33%), Positives = 107/214 (50%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V++++ V LG +G GS+ ID STI P + I E+ + D
Sbjct: 62 DIVITMVPDAPQVEAALLGTNGAAYGMAAGSICIDMSTIAPTASRAIAAKLAERQIAMLD 121
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG A+ LA M GG FER +L+V+G + G GSG V KL NN+ +
Sbjct: 122 APVSGGPARAKTGELAIMVGGEPSTFERCQAVLEVLGGAVSYIGASGSGSVVKLCNNLAI 181
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
I MA E + G+ G+E + + +VL N++A ++ E + +P S +Y+ G
Sbjct: 182 SIIAMANIEALAFGVANGVEAETIRNVLLNATASNYLLERW------LPETVFSGDYNKG 235
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLY 50
F EL+ KDL A P+ G +A Q++
Sbjct: 236 FAAELLAKDLNAVLDTARASGVPLWAGGLAQQMW 269
>UniRef50_Q2JEV5 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=6; Bacteria|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Frankia sp. (strain CcI3)
Length = 302
Score = 118 bits (283), Expect = 2e-25
Identities = 75/231 (32%), Positives = 113/231 (48%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VDVV + ++ V +V LG DGV+ + G++++D +T + ++I E G+GF
Sbjct: 58 VDVVCLCVGADDDVREVVLGADGVLGALRPGAIIVDHTTTSAELAEEIAARTAEVGVGFV 117
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPVSGG GA L+ M GG E ER+ P+L GA G +GSGQ+ K+ N +L
Sbjct: 118 DAPVSGGEAGAMAGRLSIMCGGDPETIERARPVLAAYGATITRIGPVGSGQLTKMVNQIL 177
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+ AE +N I GL+ ++L + +A SW Y G +D
Sbjct: 178 VAGAVEGAAEAINFAIAAGLDTDLVLSAVAGGAANSW----YLANRGQTMVRD---EFDF 230
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
GF + M KDL + A P+P+ +A + Q+ G G D + V
Sbjct: 231 GFAVDWMRKDLRICLAEAGRRGIPLPMIELAERDLAAAQADGEGGLDTTVV 281
>UniRef50_Q606G9 Cluster: Oxidoreductase, Gfo/Idh/MocA family; n=6;
Proteobacteria|Rep: Oxidoreductase, Gfo/Idh/MocA family
- Methylococcus capsulatus
Length = 289
Score = 117 bits (282), Expect = 2e-25
Identities = 71/228 (31%), Positives = 115/228 (50%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV+V+ ++++ VL+V + + G++++D ST+ ++ + + G F D
Sbjct: 59 DVIVTCVSADADVLEVIAA---LTPGLRPGAVIVDCSTVGVATARRAAEVVRQAGGDFLD 115
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGGV GA++ TLA M GGR E E+ P+L MG++ H G G+GQ K N ++
Sbjct: 116 APVSGGVEGARDGTLALMIGGRAETVEKVRPVLAAMGSRLMHMGDTGAGQATKAVNQVMC 175
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
A E + G + L+ ++DV++ +A +W + G S + G
Sbjct: 176 AGINQAVTEALAFGQALDLDLDKVIDVVSGGAAGNW----FLDKRGKTMIRGS---FQPG 228
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
FK L KDL + MA + P+PL + Y + +RGYG D S
Sbjct: 229 FKLSLHHKDLNICLEMAERLGIPLPLSTRSRDDYAELMARGYGDDDIS 276
>UniRef50_Q183P5 Cluster: 2-hydroxy-3-oxopropionate reductase; n=5;
Bacteria|Rep: 2-hydroxy-3-oxopropionate reductase -
Clostridium difficile (strain 630)
Length = 296
Score = 117 bits (282), Expect = 2e-25
Identities = 67/228 (29%), Positives = 121/228 (53%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V +IL + +V D+ G DG+ K+GS+++D S++ P + GL F D
Sbjct: 57 DIVFTILPNGTIVQDILFGMDGLAKTLKEGSIVVDMSSVTPTESILCANKLKDMGLEFID 116
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
+PVSGG A + TLAFMAGG++E +++ P +MG+ G GSG V KLTN +++
Sbjct: 117 SPVSGGEPKAIDGTLAFMAGGKEEIYKKVEPFFNIMGSSSILIGDNGSGSVTKLTNQVIV 176
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+T A +E + K G +P+ + + A ST + +P ++ +R++ G
Sbjct: 177 NLTIAAVSEAFVLAAKAGADPEKVYKAIRGGLA--GSTILDAKIPMIM-----NRDFKPG 229
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
K + +KD++ A + P+P+ + ++ + ++ G+ + D S
Sbjct: 230 GKISINLKDIKNVMQTAHNLDVPLPMTSQLLEIMQTLKVHGHLEDDHS 277
>UniRef50_Q9LNP0 Cluster: F1L3.35; n=8; Magnoliophyta|Rep: F1L3.35 -
Arabidopsis thaliana (Mouse-ear cress)
Length = 387
Score = 117 bits (282), Expect = 2e-25
Identities = 68/217 (31%), Positives = 111/217 (51%)
Frame = -3
Query: 652 LDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNA 473
+DV GK+G + G +D ST+D I + G F +APVSG A++
Sbjct: 166 IDVACGKNGAIFGISSGKGYVDVSTVDVASSILISKQIKDTGALFLEAPVSGSKKPAEDG 225
Query: 472 TLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNM 293
L F+ G K +E++ P L +MG +F+ G++G+G KL NM+MG + AE + +
Sbjct: 226 QLIFLTAGDKPLYEKAAPFLDIMGKSKFYLGEVGNGAAMKLVVNMIMGSMMASFAEGILL 285
Query: 292 GIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELA 113
K+GL+P VL++V++ + + P+ L + Y F + KD+ LA
Sbjct: 286 SQKVGLDPNVLVEVVSQGA-------INAPMYSLKGPSMIKSVYPTAFPLKHQQKDMRLA 338
Query: 112 SGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
G+A + P+ A A +LY++ +S G +DFS V
Sbjct: 339 LGLAESVSQSTPIAAAANELYKVAKSYGLSDEDFSAV 375
>UniRef50_Q89R44 Cluster: Oxidoreductase; n=23; Bacteria|Rep:
Oxidoreductase - Bradyrhizobium japonicum
Length = 305
Score = 116 bits (280), Expect = 4e-25
Identities = 70/227 (30%), Positives = 108/227 (47%), Gaps = 1/227 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVVVS++ + + GKDGV K S+ + S+T+DP+V +++ G + D
Sbjct: 66 DVVVSVVVNAAQTETILFGKDGVAETMPKDSVFLSSATMDPDVARRLAKQLEATGRHYLD 125
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQ-IGSGQVAKLTNNML 335
AP+SGG A L +A G F ++ P L M AK + G G G K+ N +L
Sbjct: 126 APISGGAQRAAQGELTILASGSPAAFAKARPALDAMAAKLYELGDAAGQGAAFKMINQLL 185
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
G+ A +E M K GL+ + + +V+ S+ SW E P +Y
Sbjct: 186 AGVHIAAASEAMAFAAKQGLDIRKVYEVITASAGNSWMFENRMP-------HVLDGDYTP 238
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
E+ VKDL + MA R P+P+ A A Q++ + + G G+ D
Sbjct: 239 RSAVEIFVKDLGIIQDMARSARFPVPVSAAALQMFLMTAAAGMGRDD 285
>UniRef50_Q5WBB8 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Bacillus clausii KSM-K16|Rep: 3-hydroxyisobutyrate
dehydrogenase - Bacillus clausii (strain KSM-K16)
Length = 283
Score = 116 bits (280), Expect = 4e-25
Identities = 79/230 (34%), Positives = 113/230 (49%), Gaps = 2/230 (0%)
Frame = -3
Query: 685 VVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 506
V+ L S +V D GK+GV+ H + G L+D ST D + A KG+ + D P
Sbjct: 61 VLLSLPSPNIVADTVAGKEGVLCHLQTGGFLLDLSTTDVQTTLAMEKAAAAKGIYYLDCP 120
Query: 505 VSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM-G 329
VSGG GA TL M GG K+ + PLL ++G + G G+GQ KL NNML+ G
Sbjct: 121 VSGGPAGADAGTLTIMVGGDKQAYFSVKPLLDILGDTILYVGDSGAGQTVKLCNNMLVAG 180
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG- 152
IT + +E M + G+ ++L ++ SS + +V+ L+ S +YD
Sbjct: 181 ITTL-LSETMAVASDHGVSRRLLAQIIQQSSGHNRVLDVF--GENLI-----SGSYDNVL 232
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F + M KDLEL ++ R P QLYR +G G KD + V
Sbjct: 233 FYLKHMAKDLELYMALSQDSRKPQHAAGTVNQLYRSALHQGKGDKDATAV 282
>UniRef50_Q2BFK1 Cluster: Oxidoreductase; n=1; Bacillus sp. NRRL
B-14911|Rep: Oxidoreductase - Bacillus sp. NRRL B-14911
Length = 270
Score = 116 bits (279), Expect = 6e-25
Identities = 76/230 (33%), Positives = 118/230 (51%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
+V++SIL ++K + V L ++ V+ G LI+ ++ P + K++ +KG+ D
Sbjct: 45 EVIISILPADKEMESVLLSEE-VLNVLNPGQFLIEMTSGSPEMMKKVHAAYQQKGIPVLD 103
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
PVSGG GA+N TL MAGG + ER P+L+ M + G +G G+ K N ML
Sbjct: 104 GPVSGGTAGAENGTLTVMAGGDADVLERLRPVLESMATNIYLVGSVGDGKAIKAINQMLA 163
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
GI A AE + + K+ ++ L V+ +SS SW E + GL+ R++ G
Sbjct: 164 GIHMAAAAEAVALAEKLEIDMDKLKAVVGSSSGNSWMLE--NKMDGLI-----RRDFTPG 216
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
FK LM KD+++A G +PL L++ + G KDFS V
Sbjct: 217 FKLNLMKKDIQIAVNEGNG--KQLPLANYVLDLFK-QSEKDAGDKDFSAV 263
>UniRef50_Q0S5S3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Rhodococcus sp. RHA1|Rep: 3-hydroxyisobutyrate
dehydrogenase - Rhodococcus sp. (strain RHA1)
Length = 299
Score = 116 bits (279), Expect = 6e-25
Identities = 71/208 (34%), Positives = 103/208 (49%)
Frame = -3
Query: 625 VVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGR 446
V+ +G +++D STIDP+ +++ A G F DAPVSGGV GA+ TLA M GG
Sbjct: 79 VLQQGNQGLVIVDHSTIDPDTTRRLAQDAQVAGACFLDAPVSGGVQGAEAGTLAVMLGGD 138
Query: 445 KEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPK 266
+ ++ +PL++ FH G GSGQ KL NN + +A E ++ + G++
Sbjct: 139 EASVKKVIPLIETYAGNIFHVGPSGSGQAIKLANNQITAANIVALGEGLSSAVAAGVDLD 198
Query: 265 VLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRS 86
+ VL SSA S Y P P+ GF + M KDL L A +
Sbjct: 199 TAVAVLTKSSANSNVLSNYFPKTLFTEERPT------GFALDFMHKDLGLFLNAAGKAKL 252
Query: 85 PIPLGAVATQLYRIVQSRGYGQKDFSFV 2
P P+ ++ L+ I Q G G KDF+ V
Sbjct: 253 PTPVTSLVRDLFSIGQRDGRGGKDFTSV 280
>UniRef50_Q03UI4 Cluster: 3-hydroxyisobutyrate dehydrogenase related
enzyme; n=2; Lactobacillales|Rep: 3-hydroxyisobutyrate
dehydrogenase related enzyme - Leuconostoc mesenteroides
subsp. mesenteroides (strain ATCC 8293 /NCDO 523)
Length = 287
Score = 116 bits (279), Expect = 6e-25
Identities = 72/222 (32%), Positives = 116/222 (52%), Gaps = 1/222 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+ +++ K V +V+ +DGV A AK+GS+L+D +T P + +Q+ + G D
Sbjct: 58 DITFTMVGYPKDVEEVWTSEDGVFAGAKEGSILVDMTTSTPRLAEQLAQTGADLGFKVLD 117
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG +GA+N TLA M GG ++ + P+L V+G + G G GQ K++NN+ +
Sbjct: 118 APVSGGDIGAKNGTLAIMVGGEQQVLDEIKPVLSVIGQQIVFAGSAGKGQHMKMSNNIGV 177
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
T + AE + GL+ + +V +A SWS + Y P +Y G
Sbjct: 178 AATVITMAESLVYAKAAGLDLESAYNVWRKGAAGSWSVDNYIP-------RIFQGDYAPG 230
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLY-RIVQSRG 29
F + ++KDL +A A + +P +A QL+ R+ Q G
Sbjct: 231 FYVKHLLKDLRIALDAAKEMDIDLPNTKLAEQLFERLSQEHG 272
>UniRef50_A0N0V2 Cluster: BtdhL; n=1; Azoarcus anaerobius|Rep: BtdhL
- Azoarcus anaerobius
Length = 303
Score = 116 bits (278), Expect = 7e-25
Identities = 69/226 (30%), Positives = 113/226 (50%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
+V+S+++ + + + L GV A G + ID ST+ P + ++I A KG+ + A
Sbjct: 65 IVISMVSDDAALQGITLDAGGVFEAATPGMVFIDMSTVSPALSERIAAAASAKGIHYLRA 124
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PVSG A L +A G K+ +ER LPLL+ MG K ++ G + K+ NM++G
Sbjct: 125 PVSGSTTTAAAGALTILASGPKDAYERCLPLLQAMGKKLYYLGPAEQARYLKVAINMMLG 184
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGF 149
+T E + +G + G+E +++V+NNS S P+ ++RN+ F
Sbjct: 185 VTAGMLGEALALGERGGVEWAQMIEVINNSVVGS-------PLLAYKAEMLTTRNFAPMF 237
Query: 148 KNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDF 11
M KD +LA P+PL AV+ Q + + G G+ DF
Sbjct: 238 TASQMAKDFDLALEAGRDANVPMPLAAVSRQFLGAMIASGRGELDF 283
>UniRef50_Q5L168 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=15;
Bacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Geobacillus kaustophilus
Length = 288
Score = 115 bits (277), Expect = 1e-24
Identities = 69/221 (31%), Positives = 117/221 (52%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV++++ + V VY G+ G++ +A+ G+ +ID +T P + + I+ A +KG+ D
Sbjct: 59 DVVMTMVGDPRDVEQVYFGEGGILENARPGTYVIDMTTSTPTLAQSIYEAAKQKGIHALD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG +GA+ TL M GG ++ F P+L+ +G G G+GQ K+ N + +
Sbjct: 119 APVSGGDIGAREGTLTIMVGGDEDVFLACKPILERLGTNIVRQGGAGAGQHTKMCNQIAI 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ E M + GL+P +L+ + +A SWS + L P S ++ G
Sbjct: 179 ATNMIGVCEAMAYAKRAGLDPFKVLESIAKGAAGSWS------LSNLAPRMLSG-DFAPG 231
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRG 29
F + +KD+++A A + P+P A+A QLY + G
Sbjct: 232 FYVKHFIKDMKIALEEAERMNLPLPGLALAKQLYEELAQAG 272
>UniRef50_A0FZ96 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Burkholderia phymatum STM815|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Burkholderia phymatum STM815
Length = 305
Score = 115 bits (277), Expect = 1e-24
Identities = 70/217 (32%), Positives = 116/217 (53%), Gaps = 1/217 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV+ L + V V G DG V G ++ID ++ P + + G+ D
Sbjct: 57 DVVLLCLPRSSDVHSVLFGPDGAVEGLSDGKIVIDQTSGVPAETRDFARQLADIGVALFD 116
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQ-IGSGQVAKLTNNML 335
APVSG + A T++ +A G K+ FE++LP+L+ + FHCG+ +G+GQ K NNM+
Sbjct: 117 APVSGAMATAIAGTISIIASGPKDAFEKTLPVLQSISPNVFHCGERVGNGQTMKTVNNMM 176
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+AT E + MG K GL +++ + +N ++AR+++++ G++P R
Sbjct: 177 NVSCRLATLEVVAMGRKFGLPLELMTEAINATTARNYTSQ------GMLPAIAEGRQ-ST 229
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRI 44
F L VKD+ A +A + P+P+GAVA + +I
Sbjct: 230 KFWLALQVKDIHQAITLAAEQKVPMPIGAVARSILQI 266
>UniRef50_Q12CU4 Cluster: 2-hydroxy-3-oxopropionate reductase; n=17;
Proteobacteria|Rep: 2-hydroxy-3-oxopropionate reductase
- Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 298
Score = 114 bits (275), Expect = 2e-24
Identities = 76/214 (35%), Positives = 108/214 (50%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+VVS+L + VV DV + GV A K GSL +D ++I P + G+ D
Sbjct: 67 DIVVSMLENGAVVQDVLFAQ-GVAAAMKPGSLFLDMASITPREARDHAARLGALGIAHLD 125
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
PVSGG +GA+ TL MAGG+ DFERSLPLLKV G + H G GSGQ+ KL N M++
Sbjct: 126 TPVSGGTVGAEQGTLVIMAGGKPADFERSLPLLKVFG-RATHVGPHGSGQLTKLANQMIV 184
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
GIT A AE + K G + + + + A S +++ R++
Sbjct: 185 GITIGAVAEALLFATKGGADMAKVKEAITGGFADSRVLQLH-------GQRMVERDFAPR 237
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLY 50
+ + +KD+ A A I P+ + QLY
Sbjct: 238 ARLSIQLKDMRNALATAQEIGFDAPITGLFEQLY 271
>UniRef50_A3RRS1 Cluster: 2-hydroxy-3-oxopropionate reductase; n=11;
Betaproteobacteria|Rep: 2-hydroxy-3-oxopropionate
reductase - Ralstonia solanacearum UW551
Length = 298
Score = 114 bits (275), Expect = 2e-24
Identities = 85/234 (36%), Positives = 119/234 (50%), Gaps = 6/234 (2%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKG----SLLIDSSTIDPNVPKQIFPIALEKGL 524
+VV + +TS V V LG DGV+ A +G ++ ID STI ++I GL
Sbjct: 59 EVVFTNVTSTADVEAVLLGPDGVIHGAPRGKPGSAVCIDHSTISAVATRRIAAELETAGL 118
Query: 523 GFTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTN 344
F DAPVSGG MGAQ ATL+ M GG+ E ER PLL+++G H G G+GQVAK N
Sbjct: 119 DFLDAPVSGGTMGAQKATLSIMVGGKAEVLERVRPLLQLLGTTITHIGDHGAGQVAKACN 178
Query: 343 NMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRN 164
++ I AE M G +P +L + A S ++ P + R+
Sbjct: 179 QIVQVINIQGIAEAMLFARAQGTDPSRVLAAIGPGFAGSRMLDMMGP-------KMAERD 231
Query: 163 YDGGFKNELMVKDLELASGMA--LGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
+ G + L KD L +A LG++ P + VA+QL +V S G+G+ D S
Sbjct: 232 FAAGIEARLHDKDFGLVRDIARELGLKMP-AMELVASQLDALVAS-GWGRDDTS 283
>UniRef50_A6SW62 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Janthinobacterium sp. Marseille|Rep:
3-hydroxyisobutyrate dehydrogenase - Janthinobacterium
sp. (strain Marseille) (Minibacterium massiliensis)
Length = 298
Score = 113 bits (272), Expect = 4e-24
Identities = 72/228 (31%), Positives = 111/228 (48%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D V+ +L S++VV V L DG+ GS+ ID T P V + I G+G+ D
Sbjct: 63 DAVIFMLPSDQVVRQV-LFTDGLATQLAPGSIAIDMGTSAPAVTRSISAELATLGIGYLD 121
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APV GGV+ A++A+L M G ER PL MG K + CG IGS V K N +
Sbjct: 122 APVMGGVVFAKDASLDIMVSGDDASIERCRPLFDAMGRKLWPCGDIGSAHVLKAMTNYIN 181
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ T E M +G K GL+ KV+ + ++ V +P ++ + + G
Sbjct: 182 ACALINTLEAMTIGRKFGLDSKVMAEAIDVMCNGRQHPVVKKIIPHVL-----THKFGTG 236
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
+L+ KD+++A A + + +PLG +L+R + G +D S
Sbjct: 237 MAMQLIAKDVKIAVDSAHSVGAAVPLGEATEKLWRAACEQIGGSRDHS 284
>UniRef50_Q89HA0 Cluster: Oxidoreductase; n=1; Bradyrhizobium
japonicum|Rep: Oxidoreductase - Bradyrhizobium japonicum
Length = 313
Score = 112 bits (270), Expect = 7e-24
Identities = 69/220 (31%), Positives = 110/220 (50%), Gaps = 1/220 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFP-IALEKGLGFT 515
D+V +T V +V G +G+ G L++D S+I P+ + + + G G+
Sbjct: 81 DIVFMCVTDAAAVEEVIFGAEGLSTAPGAGKLVVDFSSIHPDAARDLATRLKAANGAGWI 140
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPVSGG GA+ TLA MAGG D ER P + M + H G G+GQ AKL N ++
Sbjct: 141 DAPVSGGTKGAEEGTLAIMAGGDASDIERVRPYVLTMARRFTHMGPTGAGQTAKLCNQVI 200
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+G AE + + G++ L + L A S +++ VP +V S G
Sbjct: 201 VGCAMAVLAEATRLAVNAGIDANRLPEALAGGFADSIPLQLF--VPRMVQGIHSPPL--G 256
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQS 35
M+KDL+ + +A +P+P+ +A QL+R+ ++
Sbjct: 257 HIAT--MLKDLDTVADVAQTTSTPVPMATLAGQLFRLAKA 294
>UniRef50_Q55W03 Cluster: Putative uncharacterized protein; n=2;
Filobasidiella neoformans|Rep: Putative uncharacterized
protein - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 414
Score = 112 bits (270), Expect = 7e-24
Identities = 69/209 (33%), Positives = 110/209 (52%), Gaps = 9/209 (4%)
Frame = -3
Query: 601 SLLIDSSTIDPNVPKQIFPI---ALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDFE 431
++L+D +T+DP V I + + + DAPVSGG + A+ L M G
Sbjct: 170 TMLVDQTTLDPTVSLSISSLIHDSTSRAALMIDAPVSGGTVAAERGELTIMFGSPAPIAT 229
Query: 430 R-SLPLLKVMGAKQ--FHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVL 260
R ++PLL++M + CG G+G K+ NN+++ +A +E + +G + ++ +L
Sbjct: 230 RLAMPLLQMMAREGGVIECGGSGTGVGVKVCNNLVLASNQIALSEGLALGRSLNIDIALL 289
Query: 259 LDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPI 80
V+N SS SWS+ V P+ +P P+SR Y GGF+ LM+KD+ LA A
Sbjct: 290 QSVINTSSGSSWSSRVNPPISS-IPGTPASRGYSGGFQTRLMLKDVNLALQAANKHNLAT 348
Query: 79 PLGAVATQLYRIVQSRGYG---QKDFSFV 2
PL + + +Y + S G G KDFS+V
Sbjct: 349 PLTSASKSIYEAICSDGDGDWASKDFSWV 377
>UniRef50_Q89UN2 Cluster: Bll1384 protein; n=9; Bacteria|Rep:
Bll1384 protein - Bradyrhizobium japonicum
Length = 356
Score = 112 bits (269), Expect = 9e-24
Identities = 74/229 (32%), Positives = 114/229 (49%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
V+ V++ L S + L+V G +GV+ + ID ST+ + +I + ++ +
Sbjct: 111 VETVMASLPSLQASLEVATGTNGVI-EGSRVKRFIDLSTVGSTMASKIHGLLAKRDIVQI 169
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
D PVSGGV GA+ TLA M G K +FE P L V+G F + G+ Q KL NN L
Sbjct: 170 DCPVSGGVGGAEKGTLAVMVSGPKAEFELLKPALDVIGKVFFIGEKPGAAQTMKLANNFL 229
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+AT+E + MG+K GL+P V++DV+N S + ++ P + R +D
Sbjct: 230 SATAIVATSEAVVMGVKAGLDPAVMIDVINAGSGMNTASR------DKFPRSVLPRTFDF 283
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
GF LMVKD+ LA + + + +L+ V S DF+
Sbjct: 284 GFATGLMVKDVRLALEEMKQLGLSMEVADAVGRLWETVISAEGADSDFT 332
>UniRef50_A4IN46 Cluster: 3-hydroxyisobutyrate dehydrogenase-like
protein; n=2; Geobacillus|Rep: 3-hydroxyisobutyrate
dehydrogenase-like protein - Geobacillus
thermodenitrificans (strain NG80-2)
Length = 304
Score = 111 bits (267), Expect = 2e-23
Identities = 72/231 (31%), Positives = 115/231 (49%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VDV+ + L+ V++VY G+ GV++ A++G + +D +T+ P + + A E+G+ +
Sbjct: 58 VDVICTCLSMPDDVINVYTGEGGVLSAARRGVICLDFTTVGPKTSRFVAGRAGERGVAYL 117
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPVSGG GA+ TL M GG + +ER PLL V+G + G+ G+G AK+ N L
Sbjct: 118 DAPVSGGPEGAEQGTLTIMVGGDQAAWERVRPLLSVLGKTVEYLGESGAGSAAKILNQYL 177
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+ + +A AE M G+ GL+ L +L S S + ++P R +
Sbjct: 178 VAVHSVAAAEAMVAGVAYGLDAGKLYRLLKESYGDSRMLRRHME-QFVLP-----RQFAP 231
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
G + + KD+ LA+ I LG A + + G D S V
Sbjct: 232 GGAVKYVHKDVRLANAFMNEIGINRCLGVEAEETFAAAMDAGLADLDMSAV 282
>UniRef50_Q1N6I0 Cluster: Putative oxidoreductase protein; n=1;
Oceanobacter sp. RED65|Rep: Putative oxidoreductase
protein - Oceanobacter sp. RED65
Length = 289
Score = 110 bits (265), Expect = 3e-23
Identities = 69/228 (30%), Positives = 118/228 (51%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
++++ + +++ V + GKD + ++ K G+L+ID +T + ++ LEK + + D
Sbjct: 60 EIIILCIGNDEDVRNTLTGKDSLYSNLKPGTLVIDHTTTSAELACEMQAKLLEKQVDYVD 119
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG GA + L M GG+ ER+ + + H G IGSGQ+ K+ N + +
Sbjct: 120 APVSGGEQGAISGQLTIMCGGQALAAERAQGITQAYSKSFTHMGPIGSGQLTKMVNQICV 179
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
A AE ++ G + GL+ + ++ V+ + +A SW + T + YD G
Sbjct: 180 AGLIEALAEGIHFGQQAGLDMEKVMKVVGSGAASSWQLQ------NRYQTMLEDQ-YDFG 232
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
F + M KDLE+ A + + +P A+ QLY +Q G+GQ D S
Sbjct: 233 FAVDHMRKDLEICLKEAKKMNTSLPSTAMVDQLYGELQQSGHGQLDTS 280
>UniRef50_A6LT11 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Clostridiales|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Clostridium beijerinckii
NCIMB 8052
Length = 291
Score = 110 bits (265), Expect = 3e-23
Identities = 62/193 (32%), Positives = 106/193 (54%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV+++I+ K V +VY G++G++ +AKK S +ID +T P + +I+ A ++ + D
Sbjct: 59 DVIITIVGYPKDVEEVYFGENGILENAKKESCIIDMTTTSPKLSIKIYNEAKKREIYALD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG +GA+NATL+ M GG E FE+ +L +G + G+ G+GQ K+ N + +
Sbjct: 119 APVSGGDVGAKNATLSIMVGGDLEVFEKHKDVLSALGTNIIYEGKAGNGQHTKMANQIAL 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
E + +GL+ + +LD ++ +A SW + P ++D G
Sbjct: 179 AGAIAGVCEAITYAKGVGLDVQTMLDSISEGAAGSWQMKNMAP-------RMLKGDFDPG 231
Query: 151 FKNELMVKDLELA 113
F + +KD+ LA
Sbjct: 232 FYIKHFIKDMNLA 244
>UniRef50_A3LTC4 Cluster: 3-hydroxyisobutyrate dehydrogenase-like
protein; n=6; Saccharomycetales|Rep:
3-hydroxyisobutyrate dehydrogenase-like protein - Pichia
stipitis (Yeast)
Length = 355
Score = 110 bits (265), Expect = 3e-23
Identities = 76/229 (33%), Positives = 117/229 (51%), Gaps = 14/229 (6%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSL------LIDSSTIDPNVPKQIFPIALE 533
+D +++++ K V V +V+H +K ++ +DSSTID +++ +
Sbjct: 93 LDFIITMVPEGKHVKGVV---SELVSHYQKNNVSGTKTTFLDSSTIDIPTSREVHEFVKK 149
Query: 532 K--GLGFTDAPVSGGVMGAQNATLAFMAGG-RKEDFERSL-PLLKVMGAKQFHCGQI-GS 368
+ G F D PVSGGV GA+ ATL+FM E L LL MGA F CG+ G+
Sbjct: 150 ELPGADFIDTPVSGGVAGARKATLSFMLSRPNNESISADLRTLLNKMGANIFACGETHGA 209
Query: 367 GQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLV 188
G AKL+NN L+ +T +A A+ + GL K +++ S+ + W+ CP+PG
Sbjct: 210 GLAAKLSNNYLLAVTNLAVADSFQLAKSFGLNLKDYAKLVSVSTGKCWAAVDNCPIPGAY 269
Query: 187 P---TAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLY 50
P P+ Y+GGF ++L KDL LA+ A + LG V+ Y
Sbjct: 270 PKENNLPADVKYEGGFISKLTRKDLVLATQSAEYANRFLYLGDVSKHWY 318
>UniRef50_Q656T5 Cluster: Oxidoreductase-like; n=3; Oryza
sativa|Rep: Oxidoreductase-like - Oryza sativa subsp.
japonica (Rice)
Length = 341
Score = 109 bits (263), Expect = 5e-23
Identities = 69/230 (30%), Positives = 109/230 (47%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV ++L + ++V G +G G +D ST+D K I G F +
Sbjct: 108 DVTFAMLADPESAVEVACGANGAAQGMAPGKGYVDVSTVDAATSKLIGKHITSTGASFLE 167
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG A++ L F+ G + + R LL VMG +F G +G G KL NM+M
Sbjct: 168 APVSGSKKPAEDGLLIFLTAGDESLYNRVASLLDVMGKSRFFLGDVGKGADMKLVVNMVM 227
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G ++ +E + + K+GL+P L++V++ + + P+ L + Y
Sbjct: 228 GSMMVSFSEGLLLSEKVGLDPNTLVEVISQGA-------ISAPMFSLKGPSMVKAAYPTA 280
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F + KDL LA +A + IP A A +LY++ +S G +DFS V
Sbjct: 281 FPLKHQQKDLRLALALAESVSQSIPTVAAANELYKVAKSLGLADQDFSAV 330
>UniRef50_A3X9R7 Cluster: 3-hydroxyisobutyrate dehydrogenase family
protein; n=2; Rhodobacterales|Rep: 3-hydroxyisobutyrate
dehydrogenase family protein - Roseobacter sp. MED193
Length = 300
Score = 109 bits (262), Expect = 6e-23
Identities = 65/180 (36%), Positives = 95/180 (52%), Gaps = 2/180 (1%)
Frame = -3
Query: 616 HAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKED 437
+ KKGS+++D+ST +P+ K++ A G F D PVSGG +GA+ T+ + GG +
Sbjct: 93 YLKKGSIVVDTSTSEPDTTKRLAAAAESNGYTFLDGPVSGGPLGARTGTMTMVVGGDEAG 152
Query: 436 FERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLL 257
F + PLL+ M K H G G+G K+ NN+L + +E M + G+ LL
Sbjct: 153 FTKVRPLLEKMTGKLVHIGPSGAGHTVKIANNLLCAANLVLMSEMAQMAERAGISLTELL 212
Query: 256 DVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMA--LGIRSP 83
+N S RS +EV P ++ YD GF LM KD+ LA+G+A LGI P
Sbjct: 213 TGINAGSGRSGVSEVN------FPKWITNEAYDSGFTMGLMRKDVGLATGLAERLGIDLP 266
>UniRef50_A0LDJ3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Magnetococcus sp. MC-1|Rep: 3-hydroxyisobutyrate
dehydrogenase - Magnetococcus sp. (strain MC-1)
Length = 292
Score = 109 bits (262), Expect = 6e-23
Identities = 70/230 (30%), Positives = 110/230 (47%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D +V +++ +L+V G GV + G ++I++ST+ +Q + + G F D
Sbjct: 59 DYMVIMVSDPAALLEVLQGPVGVCSADLTGKVVINASTVSVEASQQAATLVEQVGGAFLD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG + AQ L F+AGG +R PLL MG+ CG +G G KL N+LM
Sbjct: 119 APVSGSKIPAQTGKLVFLAGGHHAVIQRCEPLLLSMGSAVIPCGAVGDGTRMKLAMNLLM 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
A AE + + GLE ++ +D + NS ++ P+ G+ A +R+++
Sbjct: 179 SGMVQALAESLLLVRNSGLEDQLFMDAIKNS-------VLFAPILGMKGQAFLNRDFEPH 231
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F L+ KDL L AL +P G Q Y +G G D + +
Sbjct: 232 FPLHLLYKDLNLIHAQALEHHVALPAGDAIRQGYAQAMQQGLGGLDIAAI 281
>UniRef50_Q0RCX7 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Frankia alni ACN14a|Rep: 3-hydroxyisobutyrate
dehydrogenase - Frankia alni (strain ACN14a)
Length = 313
Score = 109 bits (261), Expect = 8e-23
Identities = 73/230 (31%), Positives = 108/230 (46%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV + ++ V V LG DG + G+ ++D +T + +I A E G+GF D
Sbjct: 59 DVVCVCVGADDDVRSVLLGPDGALGALAPGATIVDHTTTSAELAVEIAARAAEVGVGFVD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG GA+ L+ M GG + ER P+L GA G +G+GQ+ K+ N +L+
Sbjct: 119 APVSGGQAGAEAGRLSVMCGGEVDTVERVRPVLAAYGATITRIGPVGTGQLTKMVNQILV 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
AE +N GL+ +L ++ +A SW + T +D G
Sbjct: 179 AGAIEGAAEALNFAAAAGLDLDQVLPAVSGGAASSWY------LTNRAATMIRD-EFDFG 231
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F + M KDL + A P+PL +A Q+RG GQ D + V
Sbjct: 232 FAVDWMRKDLRICLAEAARRGVPVPLTELAEGDLAASQARGDGQLDATAV 281
>UniRef50_Q13PY3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Burkholderiales|Rep: 3-hydroxyisobutyrate dehydrogenase
- Burkholderia xenovorans (strain LB400)
Length = 302
Score = 108 bits (260), Expect = 1e-22
Identities = 74/229 (32%), Positives = 114/229 (49%), Gaps = 1/229 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
+VV L VV +V G GV + +++D ST P+V I ++ + F
Sbjct: 58 EVVFLSLPLPSVVEEVATGPHGV-SQGSSVRIVVDLSTTGPSVSNVIARKLADRHIQFLG 116
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQ-IGSGQVAKLTNNML 335
APVSGG + A+ TL MA G E FE P L+V+G F+ G G GQ K+ NN L
Sbjct: 117 APVSGGTVAAEKGTLTVMAAGPMEAFETVEPWLRVIGKNIFYLGSGAGLGQTMKIINNTL 176
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+ +A+ E + G+K GL+ ++LD+LN SS RS++T +P R++
Sbjct: 177 CAVGMVASCEALVFGVKAGLDSAMMLDILNVSSGRSFAT------LEKIPQCILHRDFPM 230
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
F EL+ KD++L A + P+ + A ++G G KD++
Sbjct: 231 RFTTELIHKDVKLCIEEAEKLGVPMIVSPAARAFLSFAITQGDGGKDYA 279
>UniRef50_A3SJ77 Cluster: Probable oxidoreductase; n=1; Roseovarius
nubinhibens ISM|Rep: Probable oxidoreductase -
Roseovarius nubinhibens ISM
Length = 320
Score = 108 bits (260), Expect = 1e-22
Identities = 69/220 (31%), Positives = 105/220 (47%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
+++++IL + V + LG G+ A G+L+I+ STI P I KGL D
Sbjct: 69 EIIMTILPRDTHVRQICLGAGGIADSAAPGTLVIEMSTISPEASLDIHDALTSKGLRVLD 128
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APV AQN L MAGGR EDF + P+ + K H G GSG K+ NN +
Sbjct: 129 APVGRTPKDAQNGALLIMAGGRAEDFADAAPVFAPLADKIVHLGPKGSGIRMKIANNYMS 188
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
++ + TAE + M K G++ ++VL N++A V P L +
Sbjct: 189 MVSMVLTAETLAMARKAGIDTDAAVEVLQNTTAGRGQINVNYPKKVL------RGDISPD 242
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSR 32
F + KD+ L G+ + P+ LGA A +L+ + S+
Sbjct: 243 FPLAMGAKDISLGVGLGKSLGVPLFLGANAGELFNLAASQ 282
>UniRef50_A1R2J4 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Arthrobacter aurescens TC1|Rep: 3-hydroxyisobutyrate
dehydrogenase - Arthrobacter aurescens (strain TC1)
Length = 332
Score = 108 bits (259), Expect = 1e-22
Identities = 77/227 (33%), Positives = 111/227 (48%), Gaps = 2/227 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV+++L + K V V +G G++A G +D ST P V ++ +G+ D
Sbjct: 81 DVVITMLPTPKHVETVAMGPGGILAGMPDGGTWVDMSTSVPEVANRVREAGSVRGIRVLD 140
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQ--FHCGQIGSGQVAKLTNNM 338
APVSG +GA N L GG D ER P+ + MG + H G G+G KL N
Sbjct: 141 APVSGMSVGAANGMLQIFVGGEPADVERLRPVFEAMGDPERILHVGGHGAGYAVKLMINQ 200
Query: 337 LMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD 158
L +ATAE ++ G+K G++ +VL L S A S V V + + +YD
Sbjct: 201 LWFSHLVATAEVLSTGVKAGVDLEVLRQALIASPANSNF------VQNDVLSILNHGDYD 254
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQK 17
GF L KDL L+ +A + P+ L + QLYR ++ YG K
Sbjct: 255 EGFAIALACKDLGLSVDLARSVGVPMELSGLVEQLYRRAKAL-YGDK 300
>UniRef50_Q9HLR4 Cluster: Putative uncharacterized protein Ta0161;
n=2; Thermoplasma|Rep: Putative uncharacterized protein
Ta0161 - Thermoplasma acidophilum
Length = 290
Score = 108 bits (259), Expect = 1e-22
Identities = 71/231 (30%), Positives = 118/231 (51%), Gaps = 1/231 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D++V++L ++ V +VY + V +G + ID STI P+ +I EKG D
Sbjct: 66 DIIVTMLYDDRSVKEVYSQMEQGV----QGKVFIDMSTISPDTSIEIAKRIKEKGGKMYD 121
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APV G + + L + GG ++ L+ + + G GSG AKL NN+ +
Sbjct: 122 APVIGTSIAVEKKALVVLVGGDLSGYDEVRDLISATANQVVYMGDNGSGLYAKLVNNLFL 181
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNN-SSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
G + AE + G K G+ + DVL SSARS ++++ VP ++ S +Y
Sbjct: 182 GSYMASLAEAVRFGRKNGIPDSTISDVLTKYSSARSPTSDL--KVPKMI-----SEDYSV 234
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F + M+KD+E+ MA R +P+ ++A QL+R + GYG++D + +
Sbjct: 235 QFSIKNMLKDMEIVDRMASEKRIALPVASLALQLFRYLMDSGYGEEDIAAI 285
>UniRef50_Q830A7 Cluster: 2-hydroxy-3-oxopropionate reductase; n=7;
Firmicutes|Rep: 2-hydroxy-3-oxopropionate reductase -
Enterococcus faecalis (Streptococcus faecalis)
Length = 296
Score = 107 bits (258), Expect = 2e-22
Identities = 65/222 (29%), Positives = 106/222 (47%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D++ +++ V VY + G+ G +++D +T P + ++I A E G D
Sbjct: 59 DIIFTMVGFPSDVEGVYFNETGIFQADLTGKIVVDLTTSTPTLAEKIAKKAAEVGAHALD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG +GA+N TL M GG +E ++ LP+ K G G G GQ K+ N +++
Sbjct: 119 APVSGGDLGAKNGTLTIMVGGDQESYDTVLPIFKTFGKTFMLHGSAGKGQHTKMANQLMI 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
T E + GL + +L+ + SA +WS Y P +Y G
Sbjct: 179 AGTMTGLTEMLVYANATGLTLEKVLETVGGGSAANWSLSNYGP-------RILKEDYTPG 231
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGY 26
F + +KDL++A A + P+P AT+LY + +G+
Sbjct: 232 FFVKHFIKDLKIALDEAKKLDLPLPATQKATELYESLADKGF 273
>UniRef50_Q84VC8 Cluster: Gamma hydroxybutyrate dehydrogenase-like
protein; n=3; Magnoliophyta|Rep: Gamma hydroxybutyrate
dehydrogenase-like protein - Oryza sativa subsp.
japonica (Rice)
Length = 293
Score = 107 bits (258), Expect = 2e-22
Identities = 71/229 (31%), Positives = 115/229 (50%), Gaps = 2/229 (0%)
Frame = -3
Query: 682 VSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 503
+++L+ L V KDGV+ +G +D ST+D +I +KG F +APV
Sbjct: 61 IAMLSDPSAALSVVFDKDGVLEQIGEGKGYVDMSTVDAATSCKISEAIKQKGGAFVEAPV 120
Query: 502 SGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGIT 323
SG A++ L +A G K ++ +P V+G K F G+IG+G KL NM+MG
Sbjct: 121 SGSKKPAEDGQLVILAAGDKVLYDDMVPAFDVLGKKSFFLGEIGNGAKMKLVVNMIMGSM 180
Query: 322 GMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKN 143
A +E +++ GL P+ LLDVL+ + + P+ L + +Y+ F
Sbjct: 181 MNALSEGLSLADNSGLSPQTLLDVLDLGAIAN-------PMFKLKGPSMLQGSYNPAFPL 233
Query: 142 ELMVKDLELASGMALGIRSPI--PLGAVATQLYRIVQSRGYGQKDFSFV 2
+ KD+ LA +ALG + + P+ A + + ++ +S G G DFS V
Sbjct: 234 KHQQKDMRLA--LALGDENAVSMPVAAASNEAFKKARSLGLGDLDFSAV 280
>UniRef50_Q6UCZ9 Cluster: Predicted oxidoreductase; n=2;
environmental samples|Rep: Predicted oxidoreductase -
uncultured marine proteobacterium ANT32C12
Length = 309
Score = 107 bits (257), Expect = 3e-22
Identities = 65/228 (28%), Positives = 114/228 (50%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
+V+ + ++ V ++ GK G++ G+++ID +T + K++ +AL+K + F D
Sbjct: 79 NVIALCVGRDEDVREMMSGKKGILNSVNPGTIIIDHTTTSATLSKEMNELALQKDVIFLD 138
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
AP+SGG GA++ L+ M GG K +E P+L + G GSGQ+ K+ N + +
Sbjct: 139 APISGGQAGAESGQLSVMVGGDKASYESVKPILDNYSKFTKYMGPSGSGQLTKMVNQICI 198
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
A AE +N K+GL +++V+ +A+SW E YD G
Sbjct: 199 AGLVQALAEGVNFSEKVGLNTSDVMEVITKGAAQSWQMENRW-------ETMLKDEYDHG 251
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
F + M KDL++ S A + + I + + + Y+ +Q G+ D S
Sbjct: 252 FAVDWMRKDLDIVSEQAGQVGANIEITEMVNKFYKDIQDLDGGRWDTS 299
>UniRef50_A5GPC0 Cluster: Hydroxyacid dehydrogenase/reductase family
protein; n=14; Cyanobacteria|Rep: Hydroxyacid
dehydrogenase/reductase family protein - Synechococcus
sp. (strain WH7803)
Length = 302
Score = 107 bits (257), Expect = 3e-22
Identities = 68/226 (30%), Positives = 113/226 (50%)
Frame = -3
Query: 685 VVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 506
+V ++ + V V G +G +GSL+ID STI P+ +++ +G+ + DAP
Sbjct: 75 LVLCVSDDAAVEAVLWGDNGAGPALAEGSLVIDCSTISPSTSQRMARRLAHRGVRYLDAP 134
Query: 505 VSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGI 326
V+GG GA+ TL + GG D +R++P+L+ +G H G +GSGQ K N +L+
Sbjct: 135 VTGGTEGAKAGTLTVLCGGSDADLDRAMPVLETIGGSIHHFGAVGSGQQVKAVNQVLVAG 194
Query: 325 TGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFK 146
+ A AE + +G + L + +++ L + +A SW+ E +A S +Y GFK
Sbjct: 195 SYAAVAEAIALGQHLQLPMQQVVNALRHGAAGSWALEHR-------SSAMLSDHYPLGFK 247
Query: 145 NELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
L KDL +A A +P+ + + + G G D S
Sbjct: 248 LALHHKDLGIALQAAAEAGLDLPITQAVQAQEQTLMNAGLGDADVS 293
>UniRef50_A3WAC4 Cluster: Dehydrogenase; n=4; Bacteria|Rep:
Dehydrogenase - Erythrobacter sp. NAP1
Length = 301
Score = 107 bits (256), Expect = 3e-22
Identities = 68/228 (29%), Positives = 116/228 (50%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV++ L ++ V V G++GV+A K+G+ ID +++ P + ++I GL D
Sbjct: 68 DVVLACLGNDDDVASVLFGENGVLAAMKRGATFIDHTSVSPGLARRIADECERLGLHAVD 127
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG GA+N L+ M GG +E + P+++ A+ H G+ G+GQ AK N + +
Sbjct: 128 APVSGGQAGAENGKLSIMCGGSEEAMASAQPVMQAYAARIVHIGEAGAGQTAKAINQVCI 187
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+E + + G++ +++ ++ +A+SW E P +V S +D G
Sbjct: 188 AGVLAGLSEGVRLAQATGVDTYKVVEAISGGAAQSWQMENRWPT--MV-----SGEFDFG 240
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
F + M KDL +A A + + + Q Y VQ+ G + D S
Sbjct: 241 FAIDWMRKDLAIALEEAGKHGLDMSVTKLVDQFYSEVQAAGGNRLDTS 288
>UniRef50_Q1QWQ5 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=4; Proteobacteria|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Chromohalobacter salexigens
(strain DSM 3043 / ATCC BAA-138 / NCIMB13768)
Length = 315
Score = 106 bits (254), Expect = 6e-22
Identities = 70/228 (30%), Positives = 112/228 (49%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+VV +L+S V D+ LG +GV+AH + L+ S+I + ++ A +G+G+ D
Sbjct: 81 DIVVVMLSSGPVCDDILLGPEGVIAHMAPHATLVVMSSIPVDTAQRQAQAAEARGIGYLD 140
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG GA + TLA M GG FER PL +G + H G GSGQ+AKL N ++
Sbjct: 141 APVSGGERGAIDGTLAIMVGGDPATFERHRPLFAPLG-RAVHVGPAGSGQLAKLANQSIV 199
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
T AE + + + G +P+ + + L A S +V+ ++ G
Sbjct: 200 ANTIATVAEALLLAERGGADPRKVREALMGGFADSTILQVH-------GERMLDEDFRPG 252
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
+ KD + A +A + +P+ + L+ + + G G D S
Sbjct: 253 GPAKWQWKDTQTAQALADDLALDLPVSRLVDGLFGDLVANGDGDLDHS 300
>UniRef50_Q4WXG9 Cluster: 3-hydroxyisobutyrate dehydrogenase,
putative; n=1; Aspergillus fumigatus|Rep:
3-hydroxyisobutyrate dehydrogenase, putative -
Aspergillus fumigatus (Sartorya fumigata)
Length = 317
Score = 105 bits (253), Expect = 8e-22
Identities = 75/214 (35%), Positives = 109/214 (50%), Gaps = 3/214 (1%)
Frame = -3
Query: 679 SILTSNKVVLDVYLGKD-GVVAHAKKGSLLIDSSTIDPNVPKQIFPIALE--KGLGFTDA 509
+++ + V VYL GV+ + +L+D STID + + K F DA
Sbjct: 84 TMVPEGRHVRSVYLDSHAGVLTTSVDDKILVDCSTIDTATSMDVGAAVCQNSKTAAFYDA 143
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PVSGG +GA TL FM G ++D P L+++ F CG G AKL NN G
Sbjct: 144 PVSGGSLGAVAGTLTFMVGCVEDD-----PNLELL---IFPCGGFLLGLTAKLCNNYCSG 195
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGF 149
+ +ATAE MN+GIK G++P +L V S+A+S + + PVPG + P +
Sbjct: 196 LIAIATAEAMNIGIKSGMKPSLLARVFATSTAQSTINDKWNPVPGCLSECPGEQGV---- 251
Query: 148 KNELMVKDLELASGMALGIRSPIPLGAVATQLYR 47
+LM KDL LA A + + + LG A Q+Y+
Sbjct: 252 --QLMKKDLALAVEAADRVGAQLRLGVPALQVYQ 283
>UniRef50_A7IE35 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Proteobacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Xanthobacter sp. (strain Py2)
Length = 330
Score = 105 bits (252), Expect = 1e-21
Identities = 64/227 (28%), Positives = 106/227 (46%), Gaps = 1/227 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVVVS++ + + G DGV G++ + S+T+DP + + + G + D
Sbjct: 90 DVVVSVVVNAAQTETILFGADGVAQTLADGAVFLSSATMDPEIARTLAARLEATGRLYLD 149
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQI-GSGQVAKLTNNML 335
AP+SGG A L +A G F ++ P L M AK + G G G K+ N +L
Sbjct: 150 APISGGAQRAAEGALTILASGSPAAFAKARPALDAMAAKLYELGDAPGQGAAFKMINQLL 209
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
G+ A +E + + GL+ + +V+ S+ SW E +P +V +Y
Sbjct: 210 AGVHIAAASEAVAFAARQGLDIAKVYEVITASAGNSWMFE--NRMPHVV-----DGDYTP 262
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
++ VKDL + MA + P+P+ A A Q++ + G G+ D
Sbjct: 263 RSAVDIFVKDLGIIQDMARSAKFPVPVSAAALQMFLATSAAGMGRDD 309
>UniRef50_A6P2M7 Cluster: Putative uncharacterized protein; n=2;
Bacteria|Rep: Putative uncharacterized protein -
Bacteroides capillosus ATCC 29799
Length = 321
Score = 105 bits (252), Expect = 1e-21
Identities = 68/223 (30%), Positives = 110/223 (49%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
+ V SI+ K V +VY G G++++A+ G+L++D +T P + ++I+ KGL D
Sbjct: 93 EAVFSIVGYPKDVEEVYFGDGGIISNAQPGALIVDMTTSSPALAERIWEAGKAKGLRPLD 152
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APV+GG GA+ TL+ + GG K DF+ LPL + MG H G G+GQ AKL N + +
Sbjct: 153 APVTGGDTGAKAGTLSILVGGDKVDFDACLPLFQAMGKIIVHMGSAGAGQHAKLANQIAI 212
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
E + GL LL ++ +A S+ + P + AP G
Sbjct: 213 AGALSGVCEALTYARANGLNLDDLLSAISAGAAGSFQMQSLGPKMAVGDFAP-------G 265
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYG 23
F + +KD++L+ + I +P+ R ++ G G
Sbjct: 266 FIMKHFIKDMKLSVEQSETIGLALPVLTQVLSECRSLEEAGLG 308
>UniRef50_A5USN9 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Roseiflexus|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Roseiflexus sp. RS-1
Length = 302
Score = 105 bits (252), Expect = 1e-21
Identities = 70/230 (30%), Positives = 111/230 (48%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V +ILT + V VY G+DG+++ G L I+ STI + + + ++G D
Sbjct: 59 DLVFTILTDDHAVETVYCGRDGLLSTDASGRLFIEMSTIRTSTILSLAGMVDQRGARLLD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG V A+ L + GGR D ER+ P L V+G + H G G+G KL NM M
Sbjct: 119 APVSGTVAPAREGQLLVLVGGRTSDLERARPALGVLGRRIIHLGGQGAGTTMKLVLNMTM 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
A AE + +G + GL + +LDV +S+ + P L+ G
Sbjct: 179 ACFWGALAESLAVGQQFGLNIETMLDVYLDSAVA--PPALRSKTPALLGETSEVAFDVTG 236
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
+ +L+ +A+ G+ P P+ + A + + GYG++D + V
Sbjct: 237 VRKDLLAM---VATAQDAGV--PAPVASAALAHFAAATAAGYGERDLAAV 281
>UniRef50_Q39FA8 Cluster: 2-hydroxy-3-oxopropionate reductase; n=22;
Burkholderiales|Rep: 2-hydroxy-3-oxopropionate reductase
- Burkholderia sp. (strain 383) (Burkholderia cepacia
(strain ATCC 17760/ NCIB 9086 / R18194))
Length = 287
Score = 104 bits (250), Expect = 2e-21
Identities = 72/232 (31%), Positives = 112/232 (48%), Gaps = 3/232 (1%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVV---AHAKKGSLLIDSSTIDPNVPKQIFPIALEKGL 524
VD V + + V DV G+ G++ A A++ ++D S+I P + A G+
Sbjct: 47 VDTVFVCVLDGRAVGDVVFGEHGLLSGDAAARRLQRIVDHSSIPPAATRDYAARATALGV 106
Query: 523 GFTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTN 344
G+ DAPVSGGV GAQ TLA MAGGR D + PL+ ++ H G G+GQ AKL N
Sbjct: 107 GWVDAPVSGGVPGAQAGTLAVMAGGRAADLDAVRPLIDTYASRITHMGDAGAGQTAKLCN 166
Query: 343 NMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRN 164
++ T A AE + + G++ L + L A W+ V + VP S +
Sbjct: 167 QAIVTATVTAIAEAVGLAQASGIDAARLAEAL----AGGWADSVL--LQTFVPRMTSGGH 220
Query: 163 YDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
G + KD++ + A + +P+ A Q+ R+ ++G DF+
Sbjct: 221 PPIGALSTFQ-KDVDAIADAARDTGAVMPVSATVQQVLRLGAAQGLAGADFA 271
>UniRef50_A3K497 Cluster: Probable 6-phosphogluconate dehydrogenase
protein; n=1; Sagittula stellata E-37|Rep: Probable
6-phosphogluconate dehydrogenase protein - Sagittula
stellata E-37
Length = 298
Score = 104 bits (250), Expect = 2e-21
Identities = 65/208 (31%), Positives = 116/208 (55%), Gaps = 5/208 (2%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYL--GKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
V++++L + +V V G+ G++ + G+L+ID+++ P +++ + +G
Sbjct: 62 VLLTMLPNGAIVRKVLDEGGEAGLLGQMQPGTLMIDTTSSPPEATRELAAVLNARGCHLV 121
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKED-FERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNM 338
DAPVSG GA+ A L FM G + ER+ +L +G + FH G +G+G K NN
Sbjct: 122 DAPVSGARAGAEAADLVFMIGCDDDAVLERTRAVLSCLGNRLFHLGPVGAGHAMKALNNY 181
Query: 337 LMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD 158
+ +A AE M +G ++GL+P ++DVLN S+ R++STEV +P ++ +++
Sbjct: 182 VSAAGYVAAAEAMIIGTEVGLDPAQIVDVLNVSTGRNFSTEV--SMPRIL-----RGDFE 234
Query: 157 GGFKNELMVKDLELAS--GMALGIRSPI 80
F EL KD+ +A+ G G+ +P+
Sbjct: 235 RRFTLELYTKDVRIAANLGDRAGVTAPL 262
>UniRef50_A0G5F9 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Burkholderia|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Burkholderia phymatum
STM815
Length = 307
Score = 104 bits (250), Expect = 2e-21
Identities = 75/228 (32%), Positives = 113/228 (49%), Gaps = 1/228 (0%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
+V + L + + V LG DG + +L+D ST+ V K++ L KG+ DA
Sbjct: 71 IVFTSLPTPAIFRQVALG-DGGLIEGSAIKVLVDLSTVGSRVEKEVAQGLLAKGVETVDA 129
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCG-QIGSGQVAKLTNNMLM 332
PVSGG GA+ TLA MA G E L V+G K F G + G GQ+ KL NNML
Sbjct: 130 PVSGGAAGAKKGTLAIMAAGSPVALEEVRGLFDVLG-KAFVVGDKAGQGQLLKLLNNMLS 188
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
T+E G++ GL+P+V++ V+N S ++ +T P L P S +D G
Sbjct: 189 STAFAITSEAFVAGVRGGLDPEVMMSVINAGSGKNGATLDKFPKHVL----PGS--FDFG 242
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
F + KD+ LA + P+ +G+VA Q++ + +D +
Sbjct: 243 FPVGSVCKDIGLAVDECQALGVPMWVGSVARQMWNYAAMQDGAARDMT 290
>UniRef50_A4SWE8 Cluster: 2-hydroxy-3-oxopropionate reductase
precursor; n=7; Proteobacteria|Rep:
2-hydroxy-3-oxopropionate reductase precursor -
Polynucleobacter sp. QLW-P1DMWA-1
Length = 299
Score = 104 bits (249), Expect = 2e-21
Identities = 66/214 (30%), Positives = 101/214 (47%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D++ +++ V V G+ GV KG +++D S+I P K G + D
Sbjct: 60 DIIFTMVPDTPDVEKVLFGEHGVAHGLSKGKIVVDMSSISPIATKDFAKKINALGCEYLD 119
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG +GA+ TL M GG++ F+ P+ +MG G G+GQV K+ N +++
Sbjct: 120 APVSGGQVGAKGGTLTIMVGGKESVFQTVKPMFDLMGKNITLVGDNGAGQVTKVANQIIV 179
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ A AE + K G +P + + L A S EV+ R +D G
Sbjct: 180 ALNIEAVAEALLFASKAGADPARVREALMGGFASSKILEVHA-------ERMIKRTFDPG 232
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLY 50
F+ EL KDL LA A + +P A A +L+
Sbjct: 233 FRIELHQKDLNLALNSARALGVSLPNTANAQELF 266
>UniRef50_A1B741 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3;
Bacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Paracoccus denitrificans (strain Pd 1222)
Length = 309
Score = 104 bits (249), Expect = 2e-21
Identities = 73/226 (32%), Positives = 109/226 (48%), Gaps = 1/226 (0%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
+V + L + V + G G+V G++ +D ST +V +QI KG+ F DA
Sbjct: 59 IVFTSLPTPADVRNAGFGPRGLVEGMAPGTVWLDLSTNSVDVVRQIHAELAPKGIHFIDA 118
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PVSGG GA + LA GG +E ++R LP L+ M + + G IG+G +AKL NNM
Sbjct: 119 PVSGGPAGAASGQLAIWCGGEREVYDRCLPWLEKMADQPRYIGDIGAGTIAKLVNNMAST 178
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD-GG 152
AE ++MG+K GLEP L + + +A +Y + A YD
Sbjct: 179 AIISVLAEALSMGVKAGLEPGPLWEAIRTGAA--GRMRMYDNIGRRFMQA----KYDPPS 232
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
F L+ KD LA + P+ L + R +RG+G++D
Sbjct: 233 FALRLIHKDASLALQVGRDFGVPMRLCTLVESDIREALNRGWGERD 278
>UniRef50_Q7VYY0 Cluster: Putative oxidoreductase; n=4;
Bordetella|Rep: Putative oxidoreductase - Bordetella
pertussis
Length = 305
Score = 103 bits (248), Expect = 3e-21
Identities = 66/199 (33%), Positives = 102/199 (51%), Gaps = 3/199 (1%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDG---VVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLG 521
D V+++L ++ + V LG DG ++ + G+ ++D + +P +++ +GL
Sbjct: 65 DTVITMLPNSAITNAVVLGGDGQPGLIDLLESGAAIVDMGSSNPADTRRLSEQLAARGLT 124
Query: 520 FTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNN 341
DAPVSG V A TLA MAG + D R P+L+ MGA H G +GS K NN
Sbjct: 125 LIDAPVSGAVAKASTGTLAIMAGAAEADLRRVRPILERMGAAIIHTGAVGSAHAMKALNN 184
Query: 340 MLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNY 161
+ +A +E M + +M L+ +V DVLN SS R+ ++E ++P Y
Sbjct: 185 YVYAAGLLAVSEAMVIARRMELDLEVFTDVLNASSGRNVASETKLR-QFIIP-----GTY 238
Query: 160 DGGFKNELMVKDLELASGM 104
+GGF LM KDL A +
Sbjct: 239 NGGFALALMAKDLGTAQSL 257
>UniRef50_Q3DYV4 Cluster: NADP oxidoreductase, coenzyme
F420-dependent:6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Chloroflexus|Rep: NADP oxidoreductase,
coenzyme F420-dependent:6-phosphogluconate
dehydrogenase, NAD-binding - Chloroflexus aurantiacus
J-10-fl
Length = 289
Score = 103 bits (248), Expect = 3e-21
Identities = 64/201 (31%), Positives = 98/201 (48%)
Frame = -3
Query: 610 KKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDFE 431
++G L+ID + DP + +G+G+ DAPVSGG GA TLA M GG D E
Sbjct: 79 REGQLIIDMGSSDPRHSQTHATTLANRGIGWVDAPVSGGPEGAAAGTLAIMVGGTASDVE 138
Query: 430 RSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDV 251
R+ P+L+ +G + H G G+G K+ N +++G+T A AE M + G++P +L
Sbjct: 139 RAEPILRALG-RPTHVGPPGAGHTVKVINQLIVGLTIQAVAEAMVLAEAYGIDPALLRTA 197
Query: 250 LNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIPLG 71
L A S +++ ++R Y G K +KDL +A+ MA +P
Sbjct: 198 LAGGFADSKVLQIH-------GQRMAARRYTPGGKVTTQLKDLRMAAAMASAAGIALPHL 250
Query: 70 AVATQLYRIVQSRGYGQKDFS 8
Y + RG G+ D S
Sbjct: 251 NDTIARYETLVERGLGELDHS 271
>UniRef50_Q121N3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=19;
Burkholderiales|Rep: 3-hydroxyisobutyrate dehydrogenase
- Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 298
Score = 103 bits (248), Expect = 3e-21
Identities = 65/231 (28%), Positives = 111/231 (48%), Gaps = 1/231 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
+VVVS++ + DV + GV + K GS+ + ST+DP + G+ + D
Sbjct: 61 EVVVSVVVNAAQTEDVLWSEQGVASAMKSGSVFVMCSTVDPQWSIATEARLDKLGIHYVD 120
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQ-IGSGQVAKLTNNML 335
AP+SGG A + M+ R +E++ +L M K + G G+G K+ N +L
Sbjct: 121 APISGGAAKAAAGQMTVMSSARPAAYEKAGDVLAAMAGKVYRLGDCAGAGSKVKIINQLL 180
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
G+ A AE M +G++ G++P L +V+ +S+ SW E + +Y
Sbjct: 181 AGVHIAAAAEAMALGLREGVDPNALYEVITHSAGNSWMFENRM-------AHVLAGDYTP 233
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
++ VKDL L A + P+PL + A Q++ + G+ ++D S V
Sbjct: 234 LSAVDIFVKDLGLVLDTARASKFPLPLSSTAHQMFMQASTAGFAREDDSAV 284
>UniRef50_Q73P00 Cluster: 3-hydroxyacid dehydrogenase family
protein; n=4; Bacteria|Rep: 3-hydroxyacid dehydrogenase
family protein - Treponema denticola
Length = 292
Score = 103 bits (247), Expect = 4e-21
Identities = 63/224 (28%), Positives = 111/224 (49%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
++ +I+ + V + Y G+ G++ AK G++ D +T P + K+I+ A +K DA
Sbjct: 64 IIFTIVGYPQDVEETYFGEKGLLKTAKPGTIFADMTTSSPILAKKIYDEAKKKECFSVDA 123
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PVSGG +GA+N TL+ MAGG + F+ P MG G G+GQ K+ N + +
Sbjct: 124 PVSGGDIGAKNGTLSIMAGGDESAFKELEPFFACMGKTWALQGGAGAGQHTKMANQIAVA 183
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGF 149
T E + GL+P +L + +A SW ++ P ++ +++ GF
Sbjct: 184 ANLFGTVEAVCYAEAAGLDPHKMLSAIGGGAAGSW--QILNNGPKML-----QKDFAPGF 236
Query: 148 KNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQK 17
+ +KDL + +A ++ IP+ +A + + GY +K
Sbjct: 237 YIKHFLKDLNITLNVAKELKLHIPVLELAQNFFNKMNEEGYAEK 280
>UniRef50_Q0F1Y7 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding protein; n=1; Mariprofundus ferrooxydans
PV-1|Rep: 6-phosphogluconate dehydrogenase, NAD-binding
protein - Mariprofundus ferrooxydans PV-1
Length = 289
Score = 103 bits (247), Expect = 4e-21
Identities = 68/230 (29%), Positives = 108/230 (46%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV++ +LT + V V G++G+++ +G +I+ ST+ K+ + G+ D
Sbjct: 60 DVIILMLTGEEAVDAVLFGEEGLLSGDCEGKTVINMSTVPVECSKRWAKELADHGMTLID 119
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG + AQ TL +AGG + PLL MG K +CG GSG KL N+L+
Sbjct: 120 APVSGSKVPAQTGTLVILAGGPEAAVRAQEPLLLSMGKKVIYCGPTGSGSAMKLAINLLL 179
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
GI AE +++ GL + LLD + S + C + L + NY
Sbjct: 180 GIMTEGIAEALHLAESSGLASETLLDAVA-------SGPLSCTLFHLKEEMFKTGNYPPQ 232
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F + M KD++ A + +PLG +L+ ++DF+ V
Sbjct: 233 FPFKHMAKDMQFVLAAAAENGAHLPLGTELAKLFSPAADADLQEQDFAAV 282
>UniRef50_Q8TT25 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Methanosarcina|Rep: 3-hydroxyisobutyrate dehydrogenase -
Methanosarcina acetivorans
Length = 300
Score = 103 bits (247), Expect = 4e-21
Identities = 66/230 (28%), Positives = 108/230 (46%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D++++ LT V V G+DG++ AKKG L ID STIDP+ + A + GL D
Sbjct: 67 DIIMTSLTDEAAVNSVAFGEDGLLNGAKKGCLWIDLSTIDPSSSVKHAEAAKKAGLERLD 126
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
PV G A L + GG +E + L +G + G G+G KL N+ +
Sbjct: 127 TPVVGSKDLASKGELIILVGGSQEVLRKHEKFLNKLGKSVIYLGADGNGHKMKLAINLHL 186
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G+ + +E + K+G + K ++ +NN+ R++ ++ G P N++
Sbjct: 187 GLLAESFSEALVFSQKLGFDAKTFVETINNTPIRNYISQ------GKGPRIVEG-NFEPA 239
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F + KDL L + + +P+ V+ + Y G GQKDFS +
Sbjct: 240 FSLNNLAKDLRLVNEQITKTGAILPMTKVSIEEYSRTVQNGEGQKDFSVI 289
>UniRef50_A0LTQ8 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=1; Acidothermus cellulolyticus
11B|Rep: 6-phosphogluconate dehydrogenase, NAD-binding
precursor - Acidothermus cellulolyticus (strain ATCC
43068 / 11B)
Length = 305
Score = 103 bits (246), Expect = 6e-21
Identities = 73/230 (31%), Positives = 111/230 (48%), Gaps = 1/230 (0%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
V V ++ L + V DV+LG DGVVA A+ G ++ + ST++P V + I P KG
Sbjct: 59 VPVALTSLADRRAVEDVFLGPDGVVAGARPGLVVAELSTVEPEVARAIAPELRAKGADIL 118
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
D PVSG V A+ L M GG + P+L ++G + FH G +GSG KL N +
Sbjct: 119 DVPVSGSVAVAREGGLTLMVGGEDASLDAIRPVLDIIGRRIFHLGPLGSGAAMKLAVNTV 178
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+ A AE + + + G+ + DV +S+A + + P D
Sbjct: 179 IHGLNAALAEGLVLAERAGIPRSLAYDVFASSAAGA----PFVHYKRQAFEDPEHAPVD- 233
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGY-GQKDFS 8
F+ L+ KDLEL +ALG ++ PL A L + + + G +D S
Sbjct: 234 -FRLALVRKDLELI--LALGEQTGTPLPQAAKNLAIVAAALDHVGDRDIS 280
>UniRef50_Q94B07 Cluster: Gamma hydroxybutyrate dehydrogenase; n=16;
cellular organisms|Rep: Gamma hydroxybutyrate
dehydrogenase - Arabidopsis thaliana (Mouse-ear cress)
Length = 289
Score = 103 bits (246), Expect = 6e-21
Identities = 73/229 (31%), Positives = 113/229 (49%), Gaps = 2/229 (0%)
Frame = -3
Query: 682 VSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 503
+++L+ L V K GV+ +G ID ST+D +I KG F + PV
Sbjct: 61 IAMLSDPCAALSVVFDKGGVLEQICEGKGYIDMSTVDAETSLKINEAITGKGGRFVEGPV 120
Query: 502 SGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGIT 323
SG A++ L +A G K FE S+P V+G + F+ GQ+G+G KL NM+MG
Sbjct: 121 SGSKKPAEDGQLIILAAGDKALFEESIPAFDVLGKRSFYLGQVGNGAKMKLIVNMIMGSM 180
Query: 322 GMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKN 143
A +E + + K GL LLD+L+ + + ++ G P+ S +Y F
Sbjct: 181 MNAFSEGLVLADKSGLSSDTLLDILD---LGAMTNPMF---KGKGPSMTKS-SYPPAFPL 233
Query: 142 ELMVKDLELASGMALGIRSPI--PLGAVATQLYRIVQSRGYGQKDFSFV 2
+ KD+ LA +ALG + + P+ A A + ++ +S G G DFS V
Sbjct: 234 KHQQKDMRLA--LALGDENAVSMPVAAAANEAFKKARSLGLGDLDFSAV 280
>UniRef50_A7PEG7 Cluster: Chromosome chr11 scaffold_13, whole genome
shotgun sequence; n=2; Vitis vinifera|Rep: Chromosome
chr11 scaffold_13, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 348
Score = 102 bits (245), Expect = 7e-21
Identities = 74/224 (33%), Positives = 112/224 (50%), Gaps = 1/224 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLG-KDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
DVV SI+ V V L G ++ + G +L+D +T DP++ +I A +G
Sbjct: 106 DVVFSIVGFPSDVRSVLLDPSSGALSGLRPGGVLVDMTTSDPSLAAEIASSAASRGCFSV 165
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPVSGG GA+NATLA AGG + R PL +G K + G G GQ AKL N ++
Sbjct: 166 DAPVSGGDRGAKNATLAIFAGGDESVVRRLNPLFSHLG-KVNYMGGPGKGQYAKLANQII 224
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+ T + E M K GL+ + L+ ++ +A S S ++Y + R+++
Sbjct: 225 IASTMLGLIEGMMYAYKSGLDVALFLNAISTGAAGSKSLDLY-------GSRILKRDFEA 277
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYG 23
GF VKDL + + +P A+A QLY +++ G G
Sbjct: 278 GFFVNHFVKDLGICLIECQKMGLSLPGLALAQQLYLSLKAHGEG 321
>UniRef50_A3EW86 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Leptospirillum sp. Group II UBA|Rep:
3-hydroxyisobutyrate dehydrogenase - Leptospirillum sp.
Group II UBA
Length = 279
Score = 102 bits (244), Expect = 1e-20
Identities = 69/228 (30%), Positives = 109/228 (47%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D++ ++T + G DG+ + GSL+I+ STI P ++ L KG G+ D
Sbjct: 46 DLIFLMVTDGSASRALLEGPDGIARGLRPGSLVINMSTIAPEEAQEEALSLLAKGAGYLD 105
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
PVSG ++ A+ L +AGG ER+ P+L G K H G GSG AKL N+L+
Sbjct: 106 VPVSGSLVPAEKGELLLLAGGDGAALERARPILLHFGKKILHFGPTGSGMKAKLVINLLL 165
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ + + +G +GL+ +L ++ +S + P + R+YD
Sbjct: 166 ASHVESLVQTVLVGESLGLDGHQVLGMILDSPLAT-------PFYQIKRANLEKRSYDKA 218
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
F LM KDL+L S L R+P L + +R + G G++D S
Sbjct: 219 FSARLMAKDLDLLSLTLLRNRTPASLPFELGRHFRELVESGRGEEDVS 266
>UniRef50_Q7WG50 Cluster: Probable oxidoreductase; n=1; Bordetella
bronchiseptica|Rep: Probable oxidoreductase - Bordetella
bronchiseptica (Alcaligenes bronchisepticus)
Length = 316
Score = 101 bits (243), Expect = 1e-20
Identities = 68/230 (29%), Positives = 110/230 (47%), Gaps = 1/230 (0%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
+V+++L + + G DG + G+L I+ STI P I E+G+ D+
Sbjct: 62 LVIAMLPTATHIQAALEGADGALQGMDPGALFINMSTILPQETDLIAQRLAERGMRMLDS 121
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PV M AQ TL +A G +D R+ L MG + CG++G G K+ NN MG
Sbjct: 122 PVGRSAMEAQRGTLLILASGSAQDKARARDALLCMGNQVIDCGEVGGGSRVKVVNN-FMG 180
Query: 328 IT-GMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
I+ TAE + + GL ++ L+V+ + A + P + G
Sbjct: 181 ISLNALTAEALTLAEASGLSVELALEVMRGTIAGLGHMNI------TYPNKVLRGDLSAG 234
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F+ +L KDL LA +A R+ +P+G+ A Q Y +++G G +D+S +
Sbjct: 235 FQVDLAHKDLGLALELAARSRACVPMGSAAFQSYTAARAQGRGGQDYSAI 284
>UniRef50_P77161 Cluster: 2-hydroxy-3-oxopropionate reductase; n=99;
Proteobacteria|Rep: 2-hydroxy-3-oxopropionate reductase
- Escherichia coli (strain K12)
Length = 292
Score = 101 bits (242), Expect = 2e-20
Identities = 68/228 (29%), Positives = 105/228 (46%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D++ ++ V +V G++G + KG ++D S+I P K+ E G + D
Sbjct: 57 DIIFIMVPDTPQVEEVLFGENGCTKASLKGKTIVDMSSISPIETKRFARQVNELGGDYLD 116
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG +GA+ TL+ M GG + FER PL +++G G G GQ K+ N +++
Sbjct: 117 APVSGGEIGAREGTLSIMVGGDEAVFERVKPLFELLGKNITLVGGNGDGQTCKVANQIIV 176
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ A +E + K G +P + L A S EV+ R ++ G
Sbjct: 177 ALNIEAVSEALLFASKAGADPVRVRQALMGGFASSRILEVH-------GERMIKRTFNPG 229
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
FK L KDL LA A + +P A +L+ + G Q D S
Sbjct: 230 FKIALHQKDLNLALQSAKALALNLPNTATCQELFNTCAANGGSQLDHS 277
>UniRef50_A6GTB5 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding protein; n=1; Limnobacter sp. MED105|Rep:
6-phosphogluconate dehydrogenase, NAD-binding protein -
Limnobacter sp. MED105
Length = 299
Score = 99 bits (238), Expect = 5e-20
Identities = 56/147 (38%), Positives = 82/147 (55%), Gaps = 1/147 (0%)
Frame = -3
Query: 685 VVSILTSNKVVLDVYLGKDGVVA-HAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
+V++ +N + L +DG +A HA+ GS+++D STID I +G+ + D
Sbjct: 67 LVALNVTNTADVQSLLFRDGGIAQHAQPGSIIVDFSTIDAAAVADIARQLKSRGVDYIDC 126
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PVSGG GA+ ATL+ MAGG F R P+LK +G H G G+GQ K N M +
Sbjct: 127 PVSGGAAGARAATLSMMAGGDLAAFNRIEPMLKHLGKTIRHVGPSGAGQAIKAANQMALC 186
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVL 248
I + AE MN ++ G E V+L++L
Sbjct: 187 IQLVGIAEAMNYALEQGAELSVVLELL 213
>UniRef50_O33730 Cluster: Uncharacterized oxidoreductase Sfri_1503;
n=167; Bacteria|Rep: Uncharacterized oxidoreductase
Sfri_1503 - Shewanella frigidimarina (strain NCIMB 400)
Length = 291
Score = 99.5 bits (237), Expect = 7e-20
Identities = 63/219 (28%), Positives = 107/219 (48%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V + + ++ + V LG+ G+V G++L+D +T +V ++I + F D
Sbjct: 60 DIVFTCVGNDDDLRQVVLGEHGIVHGMHAGAILVDHTTASADVAREIAAYIEPLNIAFLD 119
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG GA+N L M GG + F+ P++ G +G+GQ+ K+ N + +
Sbjct: 120 APVSGGQAGAENGALTVMMGGDQAHFDTVKPVISAYSRCAELLGPVGAGQLTKMVNQICI 179
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
AE ++ GL+ +++V++ +A+SW E T + YD G
Sbjct: 180 AGVVQGLAEGLHFAKSAGLDGLKVIEVISKGAAQSWQME------NRYKTMWQGQ-YDFG 232
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQS 35
F + M KDL +A A S +P+ A+ Q Y VQ+
Sbjct: 233 FAIDWMRKDLGIALDEARRNGSHLPVAALVDQFYSEVQA 271
>UniRef50_Q47AR2 Cluster: NADP oxidoreductase, coenzyme
F420-dependent:6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Dechloromonas aromatica RCB|Rep: NADP
oxidoreductase, coenzyme
F420-dependent:6-phosphogluconate dehydrogenase,
NAD-binding - Dechloromonas aromatica (strain RCB)
Length = 287
Score = 99.1 bits (236), Expect = 9e-20
Identities = 67/226 (29%), Positives = 107/226 (47%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
++V+S++ V +V G V + + G + +D STI P ++I G+ F D
Sbjct: 58 ELVISMVADAPDVAEVMRG---VASAGESGLVAVDMSTIAPAAARRIGEDLAAAGIDFID 114
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG +GA +L+ MAGG F ++ P + MG H G G+GQVAK N ++
Sbjct: 115 APVSGGEVGAIAGSLSIMAGGSDAAFAKAKPAFECMGKNIVHVGASGAGQVAKAANQIVT 174
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G+ +A AE K G++ + + L A S E + RN+ G
Sbjct: 175 GMGVLAVAEAFAFAAKNGVDSAKVREALLGGFAYSKILENH-------GQRMLDRNFKPG 227
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
FK+ + KDL + A + +P A Q++ + G G++D
Sbjct: 228 FKSWMHEKDLNIVMQTAHELGLCLPGSAATAQMFNAMVGSGLGEED 273
>UniRef50_Q97ZE5 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=4;
Sulfolobaceae|Rep: 3-hydroxyisobutyrate dehydrogenase -
Sulfolobus solfataricus
Length = 289
Score = 99.1 bits (236), Expect = 9e-20
Identities = 69/228 (30%), Positives = 112/228 (49%), Gaps = 1/228 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV++++L + V V + KG +LID STI P + + G D
Sbjct: 59 DVIITMLADDYAVKSVV----EPLIPLMKGKILIDMSTISPTLSISLAKRIESNGGTMFD 114
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APV G + + L + GG K+ F+ + K + + G G G +KL NN+L+
Sbjct: 115 APVIGTSVFVEQKKLVVLVGGPKDKFDIVNDIAKETASLVVYMGPNGMGLYSKLVNNLLL 174
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNN-SSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
A AE N GI+ GLEP+ ++++L SSARS +TE+ P L+ +Y
Sbjct: 175 ASYVAAIAEAYNFGIRAGLEPQQVVNILTTLSSARSPTTEL--KAPKLL-----KEDYST 227
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDF 11
F + M KDLE+ A ++ P+ ++ +LY++ ++ GY + DF
Sbjct: 228 QFATKHMRKDLEIIMREAQNLKIITPVSSLVLELYKMAEALGYSEADF 275
>UniRef50_Q1IQE6 Cluster: 2-hydroxy-3-oxopropionate reductase
precursor; n=1; Acidobacteria bacterium Ellin345|Rep:
2-hydroxy-3-oxopropionate reductase precursor -
Acidobacteria bacterium (strain Ellin345)
Length = 282
Score = 98.7 bits (235), Expect = 1e-19
Identities = 62/228 (27%), Positives = 105/228 (46%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV ++ V V G GV + G +++DSSTI P + KG + D
Sbjct: 53 DVVWMCVSDTNAVERVLFGDGGVEPVLRAGMVVVDSSTISPVETLKFAERVRAKGADYID 112
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
AP++G +GA++A L FM G + E ++ PL MG K H G++G GQ +K++ N+ +
Sbjct: 113 APITGSKIGAESAQLIFMVGAKDETLKKLEPLFLQMGKKIVHMGEVGKGQASKISLNLQI 172
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
E + ++G+ P+ ++++ ++ RS + P R+Y
Sbjct: 173 ACIYEGFIEGFKVATQLGVNPEKFVELVQSTMVRSGVVDYKAPF-------VLKRDYTPN 225
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
F LM KDL L S A + +P ++Y G +D++
Sbjct: 226 FPLRLMRKDLLLVSDAAKQLELDLPGLKSVLEVYDEAHEAGMDDQDYA 273
>UniRef50_A0G5G5 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Proteobacteria|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Burkholderia phymatum
STM815
Length = 306
Score = 98.7 bits (235), Expect = 1e-19
Identities = 71/225 (31%), Positives = 109/225 (48%), Gaps = 2/225 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV+ L +KVV V G GV+AH + +++D ST + ++ + G+ + D
Sbjct: 58 DVVMMSLPDSKVVEAVVEGDGGVLAHCRARQIVVDLSTAAASSTIRLARRFTQSGVQYVD 117
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
A +SGG A+ L M GG + + +K H G+ G+G KL NN L
Sbjct: 118 AGISGGAAAAEKGALTLMVGGDASAVDALKWAFAPISSKVAHMGESGAGHTTKLLNNFLN 177
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
++ A+AE M G K GL+ +LLDVLN+SS +++T P +GG
Sbjct: 178 AVSLSASAEVMVAGKKAGLDLHLLLDVLNSSSGVNFAT------LNRFPKIVDGDYLEGG 231
Query: 151 FKNELMVKDLELASGMA--LGIRSPIPLGAVATQLYRIVQSRGYG 23
+LM KD+ L A LG+ S G +A+ + + + GYG
Sbjct: 232 LTGKLMTKDVVLYVDRARELGVVSLNAAGPLAS--FGLGTALGYG 274
>UniRef50_Q3W9W7 Cluster: 6-phosphogluconate dehydrogenase, NAD
binding domain; n=2; Frankia sp. EAN1pec|Rep:
6-phosphogluconate dehydrogenase, NAD binding domain -
Frankia sp. EAN1pec
Length = 286
Score = 98.3 bits (234), Expect = 2e-19
Identities = 61/183 (33%), Positives = 91/183 (49%), Gaps = 1/183 (0%)
Frame = -3
Query: 595 LIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPL 416
++D+STI + ++I + G+G+ DAPVSGGV GA+ TL M G + R P+
Sbjct: 88 VVDTSTIGVSAAQRITDLLAASGIGYVDAPVSGGVTGARARTLTVMYAGTDDACARVEPV 147
Query: 415 LKVMGAKQFHCG-QIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNS 239
L + ++ G + G Q KL NN L + AT+E + G GL+ +LDVLN +
Sbjct: 148 LAALSDRRRRVGDRPGLAQALKLANNFLAAVALAATSEAVAFGTSAGLDMGTMLDVLNTA 207
Query: 238 SARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIPLGAVAT 59
S ++ +T P L + Y GF N LM KDL L + P LG V +
Sbjct: 208 SGQNNATAEKFPRQVL------TERYSAGFANSLMAKDLRLYLQEVRELDGPTSLGTVTS 261
Query: 58 QLY 50
++
Sbjct: 262 SVW 264
>UniRef50_A1WM48 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Verminephrobacter eiseniae EF01-2|Rep:
3-hydroxyisobutyrate dehydrogenase - Verminephrobacter
eiseniae (strain EF01-2)
Length = 301
Score = 98.3 bits (234), Expect = 2e-19
Identities = 67/218 (30%), Positives = 104/218 (47%)
Frame = -3
Query: 673 LTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGG 494
L V V +DG++ K+ ++D STI P +G+ + D+PVSGG
Sbjct: 68 LPDGPAVQHVISAQDGLL-QGKRVKCVVDLSTIGPRAAVAASQALGARGIAYVDSPVSGG 126
Query: 493 VMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMA 314
+ GA+ TLA M + ++ P+LK G + G GQ KL NN+L
Sbjct: 127 IGGAERGTLAVMTACPQPLYDELAPVLKNFGRLFYMGAGPGLGQTMKLANNLLSAAAVAI 186
Query: 313 TAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELM 134
T+E M MG K GL+P V+L+V+N S R+ +T P L T ++ GF L
Sbjct: 187 TSEAMAMGAKAGLDPGVMLEVINAGSGRNSATMEKFPKAVLTGT------FNIGFAARLA 240
Query: 133 VKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQ 20
KD+ L + + P+ +GA ++ +V + YG+
Sbjct: 241 CKDVRLCLEESEALGVPMVVGAAVREML-VVTNAVYGK 277
>UniRef50_A0JXR2 Cluster: 2-hydroxy-3-oxopropionate reductase; n=2;
Arthrobacter|Rep: 2-hydroxy-3-oxopropionate reductase -
Arthrobacter sp. (strain FB24)
Length = 333
Score = 97.9 bits (233), Expect = 2e-19
Identities = 55/171 (32%), Positives = 87/171 (50%)
Frame = -3
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPVSGG GA++ TLA M G ++DF+R LPL MG G +GSG +AK N ++
Sbjct: 136 DAPVSGGTKGAEDGTLAIMVGAGEQDFQRLLPLFNAMGGTVRRLGPLGSGSLAKACNQLI 195
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+G T A AE + + G++ L ++L A S ++ P ++R+Y+
Sbjct: 196 VGTTTAALAEAAELAERSGMDVAALYELLAGGLAGSRVLDIVGP-------RLAARDYEP 248
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
+ M KDL A + + +P+ V +LY ++ +G G D + V
Sbjct: 249 TGPAKFMHKDLSFVLESAAAVDAAVPMATVGAELYAELKRQGLGDLDLAAV 299
>UniRef50_A6G049 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Plesiocystis pacifica SIR-1|Rep: 3-hydroxyisobutyrate
dehydrogenase - Plesiocystis pacifica SIR-1
Length = 307
Score = 97.5 bits (232), Expect = 3e-19
Identities = 62/228 (27%), Positives = 108/228 (47%), Gaps = 1/228 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
+ +++ + S+ V LG+ G +A +G+L+ID T + +Q+ +G F D
Sbjct: 70 EFIIACVGSDAATFAVLLGEGGALAGVGQGALVIDCGTTSLKLTEQLAAACEGEGASFLD 129
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQ-IGSGQVAKLTNNML 335
AP++G +GA+ L M G +E R++PL ++MG H + +G GQ AK NM
Sbjct: 130 APITGSKLGAEGGKLTIMVAGEEEIVARAMPLFEIMGKHTVHVSERLGDGQRAKYCLNMT 189
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+ E + + + + ++L NS+ ++ P L+ + +++
Sbjct: 190 QAVVLQGLLEGYTLAKLLDVPLTKMAEILENSAGKTGLGTF--KTPYLL-----AGDFEP 242
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDF 11
F+ +LM KDL LA A R P+P V LY + G G +DF
Sbjct: 243 HFRLDLMHKDLHLALRHAENERVPLPAATVVRGLYDQAVAEGMGPRDF 290
>UniRef50_A3VLN6 Cluster: Oxidoreductase; n=1; Rhodobacterales
bacterium HTCC2654|Rep: Oxidoreductase - Rhodobacterales
bacterium HTCC2654
Length = 293
Score = 97.5 bits (232), Expect = 3e-19
Identities = 53/155 (34%), Positives = 80/155 (51%), Gaps = 1/155 (0%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFP-IALEKGLGF 518
VDV+ +T K + V G DG+V + ++++D ST+ P+ +QI + E G +
Sbjct: 57 VDVLCLCVTDAKALDAVLFGSDGIVGAGRVPAMIVDHSTVPPDATRQIAARVRAEAGAAW 116
Query: 517 TDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNM 338
DAPVSGG+ GA LA GG D R+ P+L +G H G GSGQVAK N +
Sbjct: 117 VDAPVSGGLAGAAAGQLAIFVGGEDADVTRAWPVLTTLGTTVTHLGPTGSGQVAKACNQV 176
Query: 337 LMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSA 233
+ ++ A AE + + + + P+ L L A
Sbjct: 177 IGFLSFAALAEALALAARYDIAPRDLAVALTGGFA 211
>UniRef50_A0QUD5 Cluster: 3-hydroxyisobutyrate dehydrogenase family
protein; n=1; Mycobacterium smegmatis str. MC2 155|Rep:
3-hydroxyisobutyrate dehydrogenase family protein -
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length = 326
Score = 97.5 bits (232), Expect = 3e-19
Identities = 64/229 (27%), Positives = 112/229 (48%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
V++++L ++ V VYLG DG+VA+A+ G++L+D STI P++ ++ G+ F A
Sbjct: 68 VLLTMLGTDDDVAQVYLGDDGLVANARAGAVLVDCSTISPDMSARVRARCDRAGVHFLAA 127
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PV+GG ++ LA G ++ FE + +L+V+ + G + ++ K+ +N+L+
Sbjct: 128 PVAGGPPVIESGGLAMAVSGDRQAFEHAADVLRVVAPNLIYVGPGDTSRLVKICHNLLVA 187
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGF 149
T E + G + LL L +++ S E P+ S ++ F
Sbjct: 188 ATLEVLGELCVLAESHGASRQALLSFLRSTAISSRFIEYKAPL-------LESLDFTPAF 240
Query: 148 KNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
+ LM KDLEL G+A +P+ A YR G + D + V
Sbjct: 241 TSSLMQKDLELGLGLAGQADVTMPVTAQVHATYRAANESGLAELDAAAV 289
>UniRef50_A3WMG5 Cluster: Probable 3-hydroxyisobutyrate
dehydrogenase; n=1; Idiomarina baltica OS145|Rep:
Probable 3-hydroxyisobutyrate dehydrogenase - Idiomarina
baltica OS145
Length = 284
Score = 97.1 bits (231), Expect = 4e-19
Identities = 67/232 (28%), Positives = 116/232 (50%), Gaps = 2/232 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKD-GVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
++V++++ + V+L + G ++ I+SST+ + K++ A ++G
Sbjct: 59 ELVIAMVRDDDASAAVWLDEQTGAFKGMSDNAIAIESSTLSVDWVKELAQQAQQRGKQLI 118
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
+APVSG AQNA L ++ GG R+ P+L +MG K H G++GSG +AKL N L
Sbjct: 119 EAPVSGSRPQAQNAELVYLVGGDAHLVNRAEPVLSLMGKKVNHTGEMGSGALAKLVTNTL 178
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
MGI AE + M + G +P +L+ ++ +T V+ G+V + S YD
Sbjct: 179 MGIQVTTIAELIGMLKRQGQDPDAILEAVS-------TTPVWSKTAGIVRKSMVSEAYDP 231
Query: 154 GFKNELMVKDLELASGMALGIRSPI-PLGAVATQLYRIVQSRGYGQKDFSFV 2
F +L+ KDL G L + P+ + A ++ Q + G+ + + V
Sbjct: 232 QFPVDLIEKDL----GYCLQAADQVAPMTSAARTVFNEAQEQQLGEWNMTVV 279
>UniRef50_Q8U2W2 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=17;
Pyrococcus|Rep: 3-hydroxyisobutyrate dehydrogenase -
Pyrococcus furiosus
Length = 278
Score = 97.1 bits (231), Expect = 4e-19
Identities = 57/202 (28%), Positives = 98/202 (48%)
Frame = -3
Query: 607 KGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDFER 428
+G +++D++T + I G + ++PV G V+ A+N L + G +E FER
Sbjct: 77 RGKIIVDTTTNHHEKVLEFHEIYRNVGAFYLESPVIGSVIPARNGQLTILVSGEREAFER 136
Query: 427 SLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVL 248
P L+ +G + F+ + G KL NN ++G A E + +G K GL + ++++L
Sbjct: 137 VRPYLQKLGKRIFYFNEPGKATKLKLINNFVLGAFMAALGEAIALGEKAGLSREEIIEIL 196
Query: 247 NNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIPLGA 68
N + S V T + +Y F + +VKDL A +A+ R +PL A
Sbjct: 197 ENGAGNSM-------VLSAKKTKLLNDDYSTHFSVKNLVKDLSYAYDLAVASRKAVPLNA 249
Query: 67 VATQLYRIVQSRGYGQKDFSFV 2
++YR+ +G + DFS V
Sbjct: 250 TVREIYRLAFEKGLEELDFSVV 271
>UniRef50_A6EH53 Cluster: Putative uncharacterized protein; n=1;
Pedobacter sp. BAL39|Rep: Putative uncharacterized
protein - Pedobacter sp. BAL39
Length = 292
Score = 96.3 bits (229), Expect = 6e-19
Identities = 64/226 (28%), Positives = 107/226 (47%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V +++ + V ++ G DG+++ G ++++ ST+ P + ++ G+ + D
Sbjct: 70 DIVFLMVSDDHAVASLFEGADGLLSKELHGKVIVNMSTVSPAISIKMAAACSAVGIEYLD 129
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG V A + L M GG ++ F + PLL MG H G G G AKL N L+
Sbjct: 130 APVSGSVKQATDGQLVIMVGGEEQAFHAAEPLLSCMGKLVMHLGASGIGNKAKLAINTLL 189
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
I AE + K + + LL +L N + + V+ + G A + NY
Sbjct: 190 AIYTEGLAEIVTFSRKHQINTEDLLTLLGNGAL----SNVFTKIKG---DALLNDNYQAA 242
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
F + MVKDL LA + PL A + ++ + +G++D
Sbjct: 243 FALKHMVKDLNLAKDEGM----DTPLARTALETFKSA-AAAFGEED 283
>UniRef50_A5VEA3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=1;
Sphingomonas wittichii RW1|Rep:
2-hydroxy-3-oxopropionate reductase - Sphingomonas
wittichii RW1
Length = 264
Score = 96.3 bits (229), Expect = 6e-19
Identities = 50/161 (31%), Positives = 87/161 (54%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
+VV+ + S++ V DV G+DGV+A A+ G +++ S++ + + ++G+ D
Sbjct: 58 EVVMICVVSDQQVRDVLAGEDGVLASARPGLIVVLHSSVSTDTIAEAAKATRDRGVVLVD 117
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG GA+ T++FM GG + +R PL ++ G G G+ +AKL + + +
Sbjct: 118 APVSGGAQGARARTMSFMVGGEEAALDRCQPLFELSGPNILRTGPAGTATLAKLAHQVAI 177
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVY 209
MA AE + +G GL +++ + ARSW E +
Sbjct: 178 IGNIMAMAEAVRLGTAGGLSAEMVKQAVAGGLARSWIAETW 218
>UniRef50_A5P0V0 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=3; Rhizobiales|Rep:
6-phosphogluconate dehydrogenase, NAD-binding precursor
- Methylobacterium sp. 4-46
Length = 299
Score = 96.3 bits (229), Expect = 6e-19
Identities = 68/230 (29%), Positives = 111/230 (48%), Gaps = 1/230 (0%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
+VV+ + V+ +G + + +I +T P + + G F DA
Sbjct: 66 MVVNAAQAEAVLFGGGAPAEGALEVLAPDAAVILMATCPPQAVEGLAARVAAAGRRFVDA 125
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCG-QIGSGQVAKLTNNMLM 332
PVSGGV+GA+ +L MA E F PLL +GA+ FH G + G G K N +L
Sbjct: 126 PVSGGVVGAEAGSLTVMAAAPAEVFGAVRPLLDAVGARIFHVGTRPGQGATVKAVNQLLC 185
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G+ A AE +++ ++G++ V+L++L+ SSA SW + P ++ AP +
Sbjct: 186 GVHIAAAAEALSLAERVGVDLPVVLEILSGSSAASWM--LRDRGPRMLEEAPRVTS---- 239
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
++ VKDL + ++ +PL ++A QL+ RG G D S V
Sbjct: 240 -AVDIFVKDLGIVLEAGRDQKAALPLASLAHQLFLAASGRGEGAADDSQV 288
>UniRef50_A2C1U6 Cluster: 3-hydroxyisobutyrate dehydrogenase and
related beta-hydroxyacid dehydrogenases; n=2;
Prochlorococcus marinus|Rep: 3-hydroxyisobutyrate
dehydrogenase and related beta-hydroxyacid
dehydrogenases - Prochlorococcus marinus (strain NATL1A)
Length = 287
Score = 96.3 bits (229), Expect = 6e-19
Identities = 67/228 (29%), Positives = 105/228 (46%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D ++ +T + V V G +GV K S +ID STI P+ I E+ + + D
Sbjct: 54 DGLLICVTDDNAVESVLFGDNGVSGSLKPNSFVIDFSTISPDKSISIHKRLGEQNIFYVD 113
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
PVSGG GA N +L+ G ++D + +V+G + +G GQ K N +L+
Sbjct: 114 CPVSGGTEGAHNGSLSLFIGASEKDCLSFENIFQVLGKSINYFNGVGKGQQVKALNQILV 173
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
T A AE M +G + L ++ L +A SW E L+ P G
Sbjct: 174 AGTYAAVAEAMELGKMLELPMDDVVAALKVGAANSWPLENRSKAM-LIDKHPL------G 226
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
FK EL KDL +A+ +A I +P+ + ++ + + G G+ D S
Sbjct: 227 FKLELHHKDLSIATELAKSINIDLPIASKVKEMEQRLMQTGLGELDVS 274
>UniRef50_UPI00003C03F8 Cluster: PREDICTED: similar to CG4747-PA;
n=1; Apis mellifera|Rep: PREDICTED: similar to CG4747-PA
- Apis mellifera
Length = 413
Score = 95.5 bits (227), Expect = 1e-18
Identities = 64/234 (27%), Positives = 106/234 (45%), Gaps = 4/234 (1%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+ S + + D+ G GV+ ++ + ID + I KG + +
Sbjct: 185 DITFSCVADPQAAKDMVFGNCGVLTEISPEKGYVEMTGIDAETSQDIAEAITAKGGRYLE 244
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
A V G AQ TL +A G + F+ + MG F+ G++G+ L ++
Sbjct: 245 AQVQGSKTQAQEGTLVILAAGDRTLFDECQSCFEAMGKNSFYLGEVGNASKMNLVLQLMA 304
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G+T AE M + + GL+ K +L+VL T + C P ++ + +GG
Sbjct: 305 GVTLAGLAESMALADRAGLQQKDVLEVLE-------LTSLAC--PAILDKGKAI--IEGG 353
Query: 151 FKNEL----MVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F +L M KDL L+ GM+ + P+PL A A ++Y+ + GYG+ D S V
Sbjct: 354 FPTQLPLQHMQKDLRLSLGMSDQLEQPLPLAAAANEVYKHAKRLGYGEHDASAV 407
>UniRef50_A5VBF0 Cluster: 2-hydroxy-3-oxopropionate reductase
precursor; n=1; Sphingomonas wittichii RW1|Rep:
2-hydroxy-3-oxopropionate reductase precursor -
Sphingomonas wittichii RW1
Length = 298
Score = 95.5 bits (227), Expect = 1e-18
Identities = 69/228 (30%), Positives = 104/228 (45%), Gaps = 3/228 (1%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG-LGFTD 512
VV LT V V G+ G G+L++D STI P+ + E G + D
Sbjct: 61 VVCLCLTDADAVEQVMFGEGGAARALAPGALVVDFSTIGPDATRGFAKRLAETGDAQWLD 120
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
PVSGGV GA+ TLA +AGG +R PLL ++ A+ G +G+GQ AKL N +++
Sbjct: 121 CPVSGGVAGAEAGTLAILAGGDAAAIDRVRPLLALLSARVTRMGGVGAGQAAKLCNQLIV 180
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCP--VPGLVPTAPSSRNYD 158
+A AE M++G +G++ L A S +++ P P P P S
Sbjct: 181 ATNMLAIAEAMHVGEALGIDLAQLPVAFQGGFADSRPLQLFGPRMAPPADPGPPVS---- 236
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
+ M KD+ A + PL A ++ + G+G +D
Sbjct: 237 ---ELRTMYKDIRSIRAAAAAAEAGTPLLAGVEAMWTRLIDAGHGGED 281
>UniRef50_A1ZWM5 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Microscilla marina ATCC 23134|Rep: 3-hydroxyisobutyrate
dehydrogenase - Microscilla marina ATCC 23134
Length = 295
Score = 95.5 bits (227), Expect = 1e-18
Identities = 73/232 (31%), Positives = 108/232 (46%), Gaps = 2/232 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V S+L S +VV V G+ G ++ K +L ID STI P A + + F +
Sbjct: 58 DIVFSMLASPQVVKAVAYGQTGFLSKMKSKALWIDCSTISPAFALASAQEASKHEVVFVE 117
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APV+G A+NA L F+ GG ++ P +++MG K H G I K+ N L+
Sbjct: 118 APVAGTKSHAENAELVFLVGGGTTAIAQATPYMEMMGKKVVHIGAISKASALKILINYLL 177
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG- 155
+A AE + +G K GL+ + LL+ L N + P L A +D
Sbjct: 178 AQGMLAFAEALVVGEKQGLDRRFLLEFLPNLPVAA---------PFLKSKANKLMQHDAE 228
Query: 154 -GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F ELM KD+ L + A V+ LY+ +G G++DFS V
Sbjct: 229 VQFPLELMYKDITLFADTAEANNITNLSTDVSKNLYQTAIKQGLGREDFSAV 280
>UniRef50_Q9L7S0 Cluster: Uncharacterized oxidoreductase yihU; n=24;
Gammaproteobacteria|Rep: Uncharacterized oxidoreductase
yihU - Salmonella typhimurium
Length = 298
Score = 95.5 bits (227), Expect = 1e-18
Identities = 65/231 (28%), Positives = 108/231 (46%), Gaps = 1/231 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
+ V+++L + +V V G+ GV + +L+ID STI P + KG D
Sbjct: 59 EFVITMLPNGDLVRSVLFGEQGVCETLSREALVIDMSTIHPLQTDNLIADMQSKGFSMMD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
P+ A TL +AGG E ER+ P+L MG + + G G G KL NN +
Sbjct: 119 VPIGRTSDNAITGTLLLLAGGTAEQVERATPVLMAMGNELVNTGGPGMGIRVKLINNYMS 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSA-RSWSTEVYCPVPGLVPTAPSSRNYDG 155
+AE + +GL V L V++ ++A + T + P +
Sbjct: 179 IALNALSAEAAVLCEALGLSFDVALKVMSGTAAGKGHFTTTW-------PNKVMKGDLSP 231
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F +L KDL +A +A + P+PLGA + ++Y + ++ G G++D+S +
Sbjct: 232 AFMIDLAHKDLGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAI 282
>UniRef50_Q0FFH2 Cluster: Putative 2-hydroxyacid dehydrogenase; n=2;
Alphaproteobacteria|Rep: Putative 2-hydroxyacid
dehydrogenase - alpha proteobacterium HTCC2255
Length = 303
Score = 95.1 bits (226), Expect = 1e-18
Identities = 57/193 (29%), Positives = 96/193 (49%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VD+V +++ K + + G++G++ G + +D +T P + +++ ++ G
Sbjct: 57 VDIVFTMVFGPKQIEQIIRGENGLLHSMGPGQVWVDLTTNQPELARELAQEIIDTGAIAI 116
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPV+G V GA+N + AGG KE ER P++++MG + G GSG + KL +N L
Sbjct: 117 DAPVTGAVDGARNGNMTQFAGGDKETIERIRPVMELMGPVHY-MGSNGSGSITKLASNQL 175
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
I A E + M +K G+E + L ++ SW P + + +YD
Sbjct: 176 WAIHATAMGEALVMAVKSGVELSRAWEALKIGASESWCMHHDAP-------SVFAGHYDP 228
Query: 154 GFKNELMVKDLEL 116
F +L KDL L
Sbjct: 229 SFTLDLCQKDLNL 241
>UniRef50_A6VYD9 Cluster: 2-hydroxy-3-oxopropionate reductase
precursor; n=5; Gammaproteobacteria|Rep:
2-hydroxy-3-oxopropionate reductase precursor -
Marinomonas sp. MWYL1
Length = 300
Score = 94.7 bits (225), Expect = 2e-18
Identities = 68/232 (29%), Positives = 112/232 (48%), Gaps = 1/232 (0%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
+D V+ ++ + K V V L G+ A K + ++ S+TI K I + L
Sbjct: 63 LDAVLVLVVNAKQVNSV-LFDSGLAAALKPQTAVMVSATISAEDAKAIHQKLSQYQLLML 121
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCG-QIGSGQVAKLTNNM 338
DAPVSGG A + MA G E FE+ P+L AK ++ G +IG G K+ + +
Sbjct: 122 DAPVSGGAAKAATGDMTVMASGSVEAFEKLQPVLDATAAKVYNIGEEIGLGATVKIIHQL 181
Query: 337 LMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD 158
L G+ A AE M + + + ++ DV+ N++ SW E + +V +Y
Sbjct: 182 LAGVHIAAGAEAMALAARANIPLDLMYDVVTNAAGNSWMFE--NRMKHVV-----DGDYS 234
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
++ VKDL L + A ++ P+PL + A ++ + G+GQ+D S V
Sbjct: 235 PKSMVDIFVKDLNLVADTAKELKFPLPLSSTALNMFLSASNAGFGQEDDSAV 286
>UniRef50_A0GI22 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Burkholderia phytofirmans PsJN|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Burkholderia phytofirmans PsJN
Length = 355
Score = 94.7 bits (225), Expect = 2e-18
Identities = 59/173 (34%), Positives = 86/173 (49%)
Frame = -3
Query: 526 LGFTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLT 347
+G+ DAPVSGGV GA TLA MAGG D E PLL ++ H G +G+GQ AKL
Sbjct: 175 IGWIDAPVSGGVAGATAGTLAVMAGGAAADVEAVKPLLGAYASRVTHMGDVGAGQTAKLC 234
Query: 346 NNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSR 167
N ++ T A AE +++ + GL+ L + L A S + + P AP
Sbjct: 235 NQTIVTATLAAIAEAVSLAQRSGLDASRLTEGLAGGWADSVLLQTFVPRMTQTGLAPI-- 292
Query: 166 NYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
G F+ KD++ + A +P+P+ + QL R+ + G G+ D S
Sbjct: 293 ---GAFRT--FQKDIDTVAATAYETGTPMPVSSTVQQLLRLGAAMGLGEADLS 340
>UniRef50_Q8PK98 Cluster: 3-hydroxyisobutirate dehydrogenase; n=3;
Proteobacteria|Rep: 3-hydroxyisobutirate dehydrogenase -
Xanthomonas axonopodis pv. citri
Length = 300
Score = 94.3 bits (224), Expect = 3e-18
Identities = 69/229 (30%), Positives = 105/229 (45%), Gaps = 3/229 (1%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVY--LGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGF 518
+V+ L VVL+V L + L++D ST ++ + + F
Sbjct: 58 EVIALSLPLPSVVLEVARTLAAAAAATEMRDSLLVVDLSTTGAQTTSEVGHLLERADVSF 117
Query: 517 TDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCG-QIGSGQVAKLTNN 341
APVSGG A L MA G +ER+ PLL +G F+ G + GQ KL NN
Sbjct: 118 LSAPVSGGTAAAAQGVLTVMAAGPLAAYERARPLLDAVGRHIFYLGGDVRLGQTLKLINN 177
Query: 340 MLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNY 161
L +A+ E + G K GL+ + +LDV+N SS R ++T + G + R++
Sbjct: 178 TLYASAMLASCEALVCGAKAGLDARTMLDVINRSSGRCFATME--RLHGAL-----DRSF 230
Query: 160 DGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
F EL+ KD++L A + P+ +G A QL + G G+ D
Sbjct: 231 PVRFTTELLRKDVQLGLMAADELGVPMHVGKAALQLLDQAVADGLGEAD 279
>UniRef50_Q1YHQ4 Cluster: Putative 2-hydroxy-3-oxopropionate
reductase; n=1; Aurantimonas sp. SI85-9A1|Rep: Putative
2-hydroxy-3-oxopropionate reductase - Aurantimonas sp.
SI85-9A1
Length = 292
Score = 94.3 bits (224), Expect = 3e-18
Identities = 66/227 (29%), Positives = 105/227 (46%), Gaps = 1/227 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAK-KGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
D++ LT++ V V G DG+VA K G ++D ST + V Q+ G F
Sbjct: 59 DIIALCLTTSDAVASVVTGADGLVASRKLSGRTVVDFSTTEMAVTHQVAAAIEAVGGRFV 118
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPVSGG A+ TLA M GG ++ E + P+L+ +G + H G IG+GQ KL N +L
Sbjct: 119 DAPVSGGPGAAETGTLAIMFGGSEQAAEAARPMLEQLG-RATHMGAIGTGQATKLVNQVL 177
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
AE + + G++ + L S + P AP
Sbjct: 178 CLTNYCVAAEALRLAQAYGVDAAKIPHALEPGLGNSAVLQAIYPRMVEEDFAPR------ 231
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
G+ +++ KD E+ +P+ A A ++R++ ++G G+ D
Sbjct: 232 GYARQIL-KDFEMLHSATKAQHLALPMSAQAMTMFRMLVAQGDGELD 277
>UniRef50_Q7WCG3 Cluster: Putative uncharacterized protein; n=2;
Bordetella|Rep: Putative uncharacterized protein -
Bordetella parapertussis
Length = 296
Score = 93.9 bits (223), Expect = 3e-18
Identities = 52/160 (32%), Positives = 83/160 (51%), Gaps = 2/160 (1%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGS--LLIDSSTIDPNVPKQIFPIALEKGLGF 518
D VV +L ++ +++ LG G+ G ++ ST P+ + + G
Sbjct: 61 DAVVVLLANDAQIMETMLGGQGLAQAVPAGHRPIVCMMSTTLPDTLRALEAPLAAVGARL 120
Query: 517 TDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNM 338
DAPVSGG++GA+ TL M GG D E PL++ MG + FHCG +GS ++AK+ NNM
Sbjct: 121 VDAPVSGGIVGAEAGTLTIMMGGETADVEAVRPLMQAMGERLFHCGALGSAEIAKVINNM 180
Query: 337 LMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWST 218
L TAE + + G+ + L +L+ S+ ++ T
Sbjct: 181 LCVANMFLTAEAIELAESHGVAFESLTPILSVSTGLNFLT 220
>UniRef50_Q019Z7 Cluster: Oxidoreductase-like; n=1; Ostreococcus
tauri|Rep: Oxidoreductase-like - Ostreococcus tauri
Length = 325
Score = 93.5 bits (222), Expect = 4e-18
Identities = 68/231 (29%), Positives = 107/231 (46%), Gaps = 1/231 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDV-YLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
DVV ++++ + L V + K+G+ G +D ST+D + I + G F
Sbjct: 100 DVVFVMVSTPEAALAVAHAAKEGL----SSGKGYVDVSTVDAGTSRAIAEVVRSTGAEFL 155
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
+APVSG A++ L F+ G + + R L VMG F G +G G KL NM+
Sbjct: 156 EAPVSGSKKPAEDGALIFLCAGDEGLYTRCTDPLDVMGKAHFFLGDVGQGAKMKLVVNMI 215
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
MG A AE + + K L + LL V++ + S P+ L + + NY
Sbjct: 216 MGSMMGAFAEGLTLADKSDLSQETLLQVISLGAIAS-------PMFALKGPSMVAGNYPP 268
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F + KD+ LA +A + +P+ A A +LY+ + G +DFS V
Sbjct: 269 AFPLKHQQKDMRLAIALADELAQDMPVAAAANELYKRARRDGCDDEDFSAV 319
>UniRef50_A6SUL3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=1;
Janthinobacterium sp. Marseille|Rep:
2-hydroxy-3-oxopropionate reductase - Janthinobacterium
sp. (strain Marseille) (Minibacterium massiliensis)
Length = 304
Score = 93.1 bits (221), Expect = 6e-18
Identities = 65/206 (31%), Positives = 103/206 (50%), Gaps = 2/206 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V+++L + +V V D + K G+L+ID S+ + +++ +G+ F D
Sbjct: 65 DIVITMLEAGPIVAQVI---DAALPGLKHGALVIDMSSTRQSEAQEVHAKLAAQGVRFID 121
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGGV+GA+ +LA MAGG +DF + +L VMG G G GQ+AKL N +++
Sbjct: 122 APVSGGVVGAEAGSLAIMAGGSAQDFAEAEAVLTVMGRPTL-VGPAGCGQIAKLCNQLIV 180
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G T AE + + G +P + + A S EV+ RN+ G
Sbjct: 181 GGTLNIVAEALLLAQAGGADPTAVRAAIRGGFAESRILEVH-------GQRMLDRNFMPG 233
Query: 151 FKNELMVKDLE--LASGMALGIRSPI 80
+ + KDLE L + G+R P+
Sbjct: 234 GQVKSQFKDLENVLIAANNAGLRLPV 259
>UniRef50_UPI0000E49FD0 Cluster: PREDICTED: similar to gamma
hydroxybutyrate dehydrogenase; n=3; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to gamma
hydroxybutyrate dehydrogenase - Strongylocentrotus
purpuratus
Length = 219
Score = 92.7 bits (220), Expect = 8e-18
Identities = 60/215 (27%), Positives = 97/215 (45%)
Frame = -3
Query: 646 VYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATL 467
+ G++GV+ +G +D ST+D + + F +APV G V A +L
Sbjct: 6 IVFGENGVLEGITEGKAFVDMSTVDIGTVTGVSEAVQARDGRFMEAPVCGSVQPAMEGSL 65
Query: 466 AFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGI 287
+A G KE ++ + MG K F+ G+ KL NM++G AE M +
Sbjct: 66 IIIAAGDKELYDECESCFQAMGKKAFYLSDTGNAARMKLVINMIIGGVMCCFAEGMALAD 125
Query: 286 KMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASG 107
K GL VLLD+LN S + P+ A + Y F + KDL+LA
Sbjct: 126 KSGLSQSVLLDILNLGSIAN-------PLISGKGKAILANKYPPAFPLKYQQKDLKLALA 178
Query: 106 MALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
M+ + P+P+ + + ++ ++ G G KD S +
Sbjct: 179 MSEQVDQPLPVASAVNEQFKRAKNMGLGDKDTSAI 213
>UniRef50_Q9LM23 Cluster: Fructose-bisphosphate aldolase; n=2;
Arabidopsis thaliana|Rep: Fructose-bisphosphate aldolase
- Arabidopsis thaliana (Mouse-ear cress)
Length = 1486
Score = 92.7 bits (220), Expect = 8e-18
Identities = 68/230 (29%), Positives = 109/230 (47%), Gaps = 3/230 (1%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG--LG 521
VDV+V ++T+ DV G G V G+ ++ +ST+ P Q+ +G L
Sbjct: 411 VDVLVIMVTNEVQAEDVLYGHLGAVEAIPSGATVVLASTVSPAFVSQLERRLENEGKDLK 470
Query: 520 FTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHC-GQIGSGQVAKLTN 344
DAPVSGGV A L MA G E + + +L + K + G G+G K+ N
Sbjct: 471 LVDAPVSGGVKRAAMGELTIMASGTDEALKSAGLVLSALSEKLYVIKGGCGAGSGVKMVN 530
Query: 343 NMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRN 164
+L G+ + AE M G ++GL + L +V++NS SW E VP ++ +
Sbjct: 531 QLLAGVHIASAAEAMAFGARLGLNTRKLFNVISNSGGTSWMFE--NRVPHML-----DND 583
Query: 163 YDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
Y ++ VKDL + + + P+ + VA QL+ + G+G+ D
Sbjct: 584 YTPYSALDIFVKDLGIVTREGSSRKVPLHISTVAHQLFLAGSAAGWGRID 633
Score = 66.9 bits (156), Expect = 4e-10
Identities = 44/154 (28%), Positives = 80/154 (51%), Gaps = 1/154 (0%)
Frame = -3
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHC-GQIGSGQVAKLTNNM 338
DA V G+ + L +A GR + R+ P L M + G+IG+G K+ N +
Sbjct: 145 DAYVLKGMSELLDGKLMIIASGRSDSITRAQPYLTAMCQNLYTFEGEIGAGSKVKMVNEL 204
Query: 337 LMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD 158
L GI +A E +++G + G+ P +L D+++N++ SW + + P+ L+ + +
Sbjct: 205 LEGIHLVAAVEAISLGSQAGVHPWILYDIISNAAGNSWIYKNHIPL--LL-----KDDIE 257
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQ 56
G F +++ ++L + A + P+PL AVA Q
Sbjct: 258 GRFL-DVLSQNLAIVEDKAKSLPFPVPLLAVARQ 290
>UniRef50_Q8VYC5 Cluster: Fructose-bisphosphate aldolase; n=12;
cellular organisms|Rep: Fructose-bisphosphate aldolase -
Arabidopsis thaliana (Mouse-ear cress)
Length = 1373
Score = 92.7 bits (220), Expect = 8e-18
Identities = 68/230 (29%), Positives = 109/230 (47%), Gaps = 3/230 (1%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG--LG 521
VDV+V ++T+ DV G G V G+ ++ +ST+ P Q+ +G L
Sbjct: 378 VDVLVIMVTNEVQAEDVLYGHLGAVEAIPSGATVVLASTVSPAFVSQLERRLENEGKDLK 437
Query: 520 FTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHC-GQIGSGQVAKLTN 344
DAPVSGGV A L MA G E + + +L + K + G G+G K+ N
Sbjct: 438 LVDAPVSGGVKRAAMGELTIMASGTDEALKSAGLVLSALSEKLYVIKGGCGAGSGVKMVN 497
Query: 343 NMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRN 164
+L G+ + AE M G ++GL + L +V++NS SW E VP ++ +
Sbjct: 498 QLLAGVHIASAAEAMAFGARLGLNTRKLFNVISNSGGTSWMFE--NRVPHML-----DND 550
Query: 163 YDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
Y ++ VKDL + + + P+ + VA QL+ + G+G+ D
Sbjct: 551 YTPYSALDIFVKDLGIVTREGSSRKVPLHISTVAHQLFLAGSAAGWGRID 600
Score = 81.8 bits (193), Expect = 1e-14
Identities = 60/213 (28%), Positives = 109/213 (51%), Gaps = 3/213 (1%)
Frame = -3
Query: 685 VVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG--LGFTD 512
VV +L+ + DV G +GV+ +K ++L+ SSTI +++ EK + D
Sbjct: 62 VVVVLSHPDQIQDVIFGDEGVMKGLQKDAVLLLSSTISTLQLQKLEKQLTEKREQIFVVD 121
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHC-GQIGSGQVAKLTNNML 335
A V G+ + L +A GR + R+ P L M + G+IG+G K+ N +L
Sbjct: 122 AYVLKGMSELLDGKLMIIASGRSDSITRAQPYLTAMCQNLYTFEGEIGAGSKVKMVNELL 181
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
GI +A E +++G + G+ P +L D+++N++ SW + + P+ L+ + +G
Sbjct: 182 EGIHLVAAVEAISLGSQAGVHPWILYDIISNAAGNSWIYKNHIPL--LL-----KDDIEG 234
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQ 56
F +++ ++L + A + P+PL AVA Q
Sbjct: 235 RFL-DVLSQNLAIVEDKAKSLPFPVPLLAVARQ 266
>UniRef50_A5FTT0 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Alphaproteobacteria|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Acidiphilium cryptum (strain JF-5)
Length = 305
Score = 92.3 bits (219), Expect = 1e-17
Identities = 62/176 (35%), Positives = 92/176 (52%), Gaps = 2/176 (1%)
Frame = -3
Query: 604 GSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDFERS 425
G+LLI+ S+ P V ++I + DAPVSGGV A+ L+ M GG +D R+
Sbjct: 87 GALLIEMSSGIPGVTRRIAAGLEAAKVAMIDAPVSGGVARAKTGDLSIMTGGSADDCARA 146
Query: 424 LPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVLN 245
LL++MG H G IG+GQ K NN++ + E + +G + GL+P ++DVLN
Sbjct: 147 ETLLRLMGTTITHVGDIGAGQAMKALNNLVSAGGFLIGVEALLIGQRFGLDPAQMVDVLN 206
Query: 244 NSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELA--SGMALGIRSP 83
S+ + ST+ L SR ++ F +LM KDL +A G GI +P
Sbjct: 207 ASTGMNNSTQKKFRQFVL------SRKFNSDFSLDLMAKDLSIALEVGRDGGIATP 256
>UniRef50_Q7Q161 Cluster: ENSANGP00000013149; n=11; Culicidae|Rep:
ENSANGP00000013149 - Anopheles gambiae str. PEST
Length = 581
Score = 92.3 bits (219), Expect = 1e-17
Identities = 62/232 (26%), Positives = 106/232 (45%), Gaps = 2/232 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV S ++ +V D+ G GV++ G ++ + +DP I + KG + +
Sbjct: 353 DVTYSCVSDPQVAKDMVFGNCGVMSANLAGKGYVEMTGVDPETSNDINEAIISKGGRYLE 412
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
A + G A+ TL +A G + FE + + F+ G +G+ L M+
Sbjct: 413 AQIQGSKNQAEEGTLIILASGDRLLFEECQSCFEAISRNSFYLGDVGNATKMNLILQMIS 472
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDV--LNNSSARSWSTEVYCPVPGLVPTAPSSRNYD 158
GIT AE M + + GL+ K +L+V L N S+ + + G PT + ++
Sbjct: 473 GITLAGVAEAMALADRAGLQQKDVLEVLELTNMSSEMMLQKGNAIIKGEFPTHHALKH-- 530
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
M KDL+LA +A G+ +P+ A + ++Y+ + GYG D S V
Sbjct: 531 -------MQKDLKLALSLADGLEQSLPITAASNEVYKHAKRLGYGSHDASAV 575
>UniRef50_Q7WNK6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Bordetella bronchiseptica|Rep: 3-hydroxyisobutyrate
dehydrogenase - Bordetella bronchiseptica (Alcaligenes
bronchisepticus)
Length = 306
Score = 91.9 bits (218), Expect = 1e-17
Identities = 60/209 (28%), Positives = 96/209 (45%), Gaps = 1/209 (0%)
Frame = -3
Query: 646 VYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATL 467
V G+ G A G+ + +ST+ P + + E G G D PVSGG GAQ L
Sbjct: 79 VLFGEGGAAAALPAGATVWLASTVAPAYARGLQARLREHGAGLVDGPVSGGATGAQAGAL 138
Query: 466 AFMAGGRKEDFERSLPLLKVMGAKQFHCG-QIGSGQVAKLTNNMLMGITGMATAECMNMG 290
+A G+ + + P ++ + G + G+ KL N +L TAE + +G
Sbjct: 139 TIIASGQAQALAAAEPAMRACSSIIHRVGEEAGAASTVKLVNQLLTASHIALTAEALALG 198
Query: 289 IKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELAS 110
+ G++P VL+ V++ S+ S E P AP S ++ +KDLE+A
Sbjct: 199 ARAGVDPDVLVKVISQSAGTSRQFEKRAPRMAAGDHAPQS-------TVDIFLKDLEIAL 251
Query: 109 GMALGIRSPIPLGAVATQLYRIVQSRGYG 23
A +R P+P+ A A Q++ + G G
Sbjct: 252 DAARALRFPVPIAASAHQVFSMAAGAGDG 280
>UniRef50_Q8EW87 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Mycoplasma penetrans|Rep: 3-hydroxyisobutyrate
dehydrogenase - Mycoplasma penetrans
Length = 288
Score = 91.5 bits (217), Expect = 2e-17
Identities = 51/157 (32%), Positives = 86/157 (54%), Gaps = 1/157 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKD-GVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
+++++++ VLD+YL + G+ + + ID +T PN Q+ + KG+
Sbjct: 58 NIIMTMVGYPSDVLDIYLNDEYGIFNYVSSEQICIDFTTSSPNFAVQLANNS--KGIKVL 115
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPV+GG +GA N TL+ M GG E F++ +LK++G K + G G GQ AKL N +L
Sbjct: 116 DAPVTGGDIGALNGTLSIMVGGDFETFKKVESILKILGNKINYFGSAGKGQHAKLFNQIL 175
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSW 224
+ + ATAE +N K ++ + V + + +W
Sbjct: 176 VAVNTFATAEVLNYCKKNNVDIEAAYKVFDKTIGNNW 212
>UniRef50_O66454 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3;
cellular organisms|Rep: 3-hydroxyisobutyrate
dehydrogenase - Aquifex aeolicus
Length = 288
Score = 91.5 bits (217), Expect = 2e-17
Identities = 63/231 (27%), Positives = 107/231 (46%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VD V I+ ++ +V G+ G+V KG +ID +T ++ + + G +
Sbjct: 58 VDRVFVIVFDSQASEEVIFGEKGLVKGDIKGKTVIDMTTNHYLYAQKAYEELKKLGAFYL 117
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPV G V+ A L + GG KE FE + PL + ++ G+ G G KL NN++
Sbjct: 118 DAPVLGSVIPALKGELTIVVGGDKEKFEENKPLFEKFCRAIYYLGEAGMGSKMKLVNNIV 177
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+G AE + +G K G++ + L++VLN+ + +S+ +V ++
Sbjct: 178 LGGIMEVLAEAIAIGEKAGIDKETLINVLNDGAGKSYILDV-------KKKKLLEEDFST 230
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F L+ KDL A + + A + Y + + G+G DFS V
Sbjct: 231 HFSVNLIYKDLHYAQDLIKDLGLFSFTTAAVKETYGLARKEGFGNLDFSAV 281
>UniRef50_A1GFG2 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Salinispora arenicola CNS205|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Salinispora arenicola CNS205
Length = 315
Score = 91.5 bits (217), Expect = 2e-17
Identities = 65/223 (29%), Positives = 96/223 (43%), Gaps = 1/223 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKD-GVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
D+V+S+L + V+L D G + G+L +D ST+ P +++ ++G F
Sbjct: 59 DLVISMLRDVEAGRSVWLDPDVGALTSLAPGTLAVDCSTVTPTFSRELAACCAQRGAEFL 118
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPV G A TL F+AGG R P+L+ +G H G G+G KL N L
Sbjct: 119 DAPVLGSRPQADAGTLIFLAGGDLAVLHRIEPVLRQVGGAVHHMGPAGTGTQMKLLTNSL 178
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+ AE + L P ++ L +T V P TA +
Sbjct: 179 FAVQVATVAELIAALHGTDLAPGRAIEALA-------ATPVTGPAIATAATAMLGDTFPA 231
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGY 26
F EL+ KDLE A+ A R+ +P T YR + G+
Sbjct: 232 AFPIELVAKDLEYATADAAARRATVPSTRTTTDTYRRAINHGH 274
>UniRef50_Q39MY1 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Burkholderia sp. 383|Rep: 3-hydroxyisobutyrate
dehydrogenase - Burkholderia sp. (strain 383)
(Burkholderia cepacia (strain ATCC 17760/ NCIB 9086 /
R18194))
Length = 303
Score = 90.6 bits (215), Expect = 3e-17
Identities = 66/230 (28%), Positives = 114/230 (49%), Gaps = 1/230 (0%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
+V + L + V L V LG DGVV H L ++ STI ++ ++I ++G+ DA
Sbjct: 63 IVFACLPNRDVSLAVGLGPDGVV-HGSAVRLYVEMSTIGQDMIERIGEGLAQRGIDIVDA 121
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCG-QIGSGQVAKLTNNMLM 332
PVSGG A+ TLA + G E+ PLL+ +G + F G + G Q+ K+ NN++M
Sbjct: 122 PVSGGPSAARAGTLAMLVSGMPSAVEQVSPLLERIGKEVFPMGDRPGMAQIMKIVNNVVM 181
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ AE + MG K GL+ ++ ++++ S +S++ C + + S +D G
Sbjct: 182 AANLVVCAEGLAMGAKAGLDADRMMRLIDSGSGQSFA----C---SKIMSRAVSGAFDFG 234
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
++ KD+ L A + +P A ++ G G +DF+ +
Sbjct: 235 AALAVIEKDMALGLAEARLMDVAMPAIERARDVWHAAYEAGRGGEDFTSI 284
>UniRef50_Q49A26 Cluster: Cytokine-like nuclear factor n-pac; n=46;
Euteleostomi|Rep: Cytokine-like nuclear factor n-pac -
Homo sapiens (Human)
Length = 553
Score = 90.6 bits (215), Expect = 3e-17
Identities = 57/230 (24%), Positives = 101/230 (43%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+ + ++ K D+ LG GV+ + G +D ST+D + ++ + + +G F +
Sbjct: 325 DITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLE 384
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG + + L +A G + +E + MG F G++G+ L NM+
Sbjct: 385 APVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQTMGKTSFFLGEVGNAAKMMLIVNMVQ 444
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G AE + + G + LLD+LN S + C ++ N+
Sbjct: 445 GSFMATIAEGLTLAQVTGRSQQTLLDILNQGQLASIFLDQKC--QNIL-----QGNFKPD 497
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F + + KDL LA + + P P+ A A ++Y+ ++ D S V
Sbjct: 498 FYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAV 547
>UniRef50_Q0KC92 Cluster: 3-Hydroxyisobutyrate dehydrogenase; n=1;
Ralstonia eutropha H16|Rep: 3-Hydroxyisobutyrate
dehydrogenase - Ralstonia eutropha (strain ATCC 17699 /
H16 / DSM 428 / Stanier 337)(Cupriavidus necator (strain
ATCC 17699 / H16 / DSM 428 / Stanier337))
Length = 305
Score = 89.4 bits (212), Expect = 7e-17
Identities = 60/228 (26%), Positives = 103/228 (45%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV S + + + D++L GV A + +D ST+ P+ ++ +G F
Sbjct: 70 DVVFSTIFDDGGLRDLFLASGGVAGAATADKVFVDMSTVSPDASAEVAAALARRGAAFLR 129
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG V A +A L+ G + F+ P+L + A+Q + G +V KL NM++
Sbjct: 130 APVSGTVSLAASAQLSCFVSGPRPAFDAVQPVLACLTARQSYVGGADEARVIKLMINMMV 189
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
++ E + G + GL +++D +N+S S R+Y
Sbjct: 190 FMSTAVIGEGLAFGARAGLNRALMVDAINDSIVGSAHYRTKA-------EQLKQRDYAAV 242
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
L+VKDL+LA +A +P+ ++ Q ++Q R G D +
Sbjct: 243 GPISLVVKDLDLALAVARDNAVALPMSSLVRQYLALMQQRRQGHLDIA 290
>UniRef50_A0K0Z6 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=2; Micrococcineae|Rep:
6-phosphogluconate dehydrogenase, NAD-binding precursor
- Arthrobacter sp. (strain FB24)
Length = 301
Score = 89.4 bits (212), Expect = 7e-17
Identities = 64/183 (34%), Positives = 88/183 (48%), Gaps = 3/183 (1%)
Frame = -3
Query: 595 LIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLP- 419
+ID++T +P KQ+ +A +G F DAPVSGG GA + +L+ GG + P
Sbjct: 89 IIDTTTSEPATSKQMAHLADTQGAAFVDAPVSGGRDGAASGSLSAFVGGTDAALAAAEPV 148
Query: 418 LLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEP-KVLLDVLNN 242
LL + G K H G GSG V KL NN+L ++ E + + G++P K +
Sbjct: 149 LLALTGGKYSHIGGPGSGNVVKLLNNVLAAANLVSVGEALGVAKAYGIDPAKAAASISEA 208
Query: 241 SSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGI-RSPIPLGAV 65
S S +Y PT S +D GF LM +D LA +A I SP L AV
Sbjct: 209 SGGSRVSANMY-------PTWVLSGTHDSGFSLGLMARDAALAVEVAAQIGESPALLAAV 261
Query: 64 ATQ 56
A Q
Sbjct: 262 AGQ 264
>UniRef50_A3JU55 Cluster: Predicted dehydrogenase, with
NAD(P)-binding Rossmann-fold domain; n=2; Bacteria|Rep:
Predicted dehydrogenase, with NAD(P)-binding
Rossmann-fold domain - Rhodobacterales bacterium
HTCC2150
Length = 302
Score = 89.0 bits (211), Expect = 1e-16
Identities = 64/222 (28%), Positives = 102/222 (45%), Gaps = 2/222 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D V ++ + V V G+ G++AH KG +I S+TI P ++I + G+ D
Sbjct: 58 DAVFVMVMNGDQVKSVLFGEGGLLAHMPKGGAVILSATIKPVEAEEIGAAMADSGIHLID 117
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCG-QIGSGQVAKLTNNML 335
PVSGG GAQ TL MA G E + P+++ + A + G + G GQ K L
Sbjct: 118 TPVSGGFPGAQGGTLTMMAAGVDEVLDTYAPVMEAVSATIWCVGTEAGQGQTVKACLQSL 177
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+G AT E + K G+ +V +V+ NSS C + R ++G
Sbjct: 178 LGAMFSATFEASVLAAKAGINGEVFHNVVANSSGG-------CGITAGSLEKIIDRQFEG 230
Query: 154 -GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSR 32
G M KDL ++ G+ + P+ + A Q++ ++R
Sbjct: 231 TGSHIATMHKDLTISMGLGEQLGVPLHTASAAMQIFHAGKTR 272
>UniRef50_A7DSF1 Cluster: 2-hydroxy-3-oxopropionate reductase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
2-hydroxy-3-oxopropionate reductase - Candidatus
Nitrosopumilus maritimus SCM1
Length = 292
Score = 89.0 bits (211), Expect = 1e-16
Identities = 61/230 (26%), Positives = 107/230 (46%), Gaps = 2/230 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V+ ++ V +V ++G++ K ++ D STIDP+ K I LE G+ D
Sbjct: 59 DLVIIVVKDADAVKEVSFEREGIIKSENKKLIVADMSTIDPSESKNISDKFLEFGIHKLD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
PV GG A L MA G KE FE + + + K F G+ G KL N+ +
Sbjct: 119 IPVMGGPNVAITGDLVMMASGNKESFEECKKVFEKIANKVFFLGEKGVAHSIKLAMNLQI 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTE--VYCPVPGLVPTAPSSRNYD 158
+ +A +E + + K ++PK+ L++LN++ ++ +E + + G YD
Sbjct: 179 TMLALALSEGITLVKKADVDPKIFLEILNSTYFKTGMSENKAFKMIDG---------KYD 229
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
F E + KD+ + A + +P+ A ++Y G G D++
Sbjct: 230 PTFTLENLKKDIITMTNAAKSLGIKLPMIEKAEEVYGNAVKEGLGGIDYT 279
>UniRef50_Q89RT2 Cluster: Bll2680 protein; n=1; Bradyrhizobium
japonicum|Rep: Bll2680 protein - Bradyrhizobium
japonicum
Length = 300
Score = 88.6 bits (210), Expect = 1e-16
Identities = 58/228 (25%), Positives = 107/228 (46%), Gaps = 1/228 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
+ V++ L + + LG GV+A G++LI++ST+ ++ A +G+ +
Sbjct: 63 EAVITSLPDDTALRGALLGPAGVIAAMAPGAVLIETSTVSVEASTEVAASAQARGVLYLR 122
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG L G K+ F+ + PL + + G + AKL N+++
Sbjct: 123 APVSGNASIVHTGALTCFVSGPKDAFDNAKPLFAAFTRARTYLGPAEEARYAKLAVNLMI 182
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAP-SSRNYDG 155
++ AE + + K G+ + +L VL++S+ S + TAP +R+++
Sbjct: 183 AVSAAMMAESLALARKGGIAWQDILKVLDDSAVASPMVK--------YKTAPLRTRDFES 234
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDF 11
F + M KDL+L G + P+ L A + Y + ++G G+ DF
Sbjct: 235 TFSCKQMAKDLDLILGAGHAVGVPLQLAAQVRETYGSLVAQGDGEADF 282
>UniRef50_Q5FQ06 Cluster: Putative oxidoreductase; n=1;
Gluconobacter oxydans|Rep: Putative oxidoreductase -
Gluconobacter oxydans (Gluconobacter suboxydans)
Length = 290
Score = 88.6 bits (210), Expect = 1e-16
Identities = 61/210 (29%), Positives = 96/210 (45%)
Frame = -3
Query: 637 GKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFM 458
G++G +A G L++D+ST+ P+ +A+E G DAP+SG A+ L +
Sbjct: 73 GENGALAALTPGKLVLDTSTVSPDQADAFASLAVEHGFSLLDAPMSGSTPEAETGDLVML 132
Query: 457 AGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMG 278
GG + +R+ P+L V+G H G GS KL N +MG T AE ++ G+ G
Sbjct: 133 VGGDEAVVKRAQPVLDVIGKLTIHAGPAGSAARLKLVVNGVMGATLNVIAEGVSYGLAAG 192
Query: 277 LEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMAL 98
L+ V+ D L V P +R + F LM KD+ L
Sbjct: 193 LDRDVVFDTLQ-------QVAVVSPHHKRKLKMGQNREFPSQFPTRLMSKDMGLLLDAGR 245
Query: 97 GIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
+ + +P AVA Q + +R + +D+S
Sbjct: 246 KVGAFMPGMAVADQALAL-SNRLHANEDYS 274
>UniRef50_Q46TQ0 Cluster: UDP-glucose/GDP-mannose
dehydrogenase:Prephenate dehydrogenase:NADP
oxidoreductase, coenzyme
F420-dependent:6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Ralstonia eutropha JMP134|Rep:
UDP-glucose/GDP-mannose dehydrogenase:Prephenate
dehydrogenase:NADP oxidoreductase, coenzyme
F420-dependent:6-phosphogluconate dehydrogenase,
NAD-binding - Ralstonia eutropha (strain JMP134)
(Alcaligenes eutrophus)
Length = 294
Score = 88.6 bits (210), Expect = 1e-16
Identities = 56/204 (27%), Positives = 96/204 (47%)
Frame = -3
Query: 613 AKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDF 434
A+ G+L ID+ST+ P + P+ + + + VSG A+ A L + G + +
Sbjct: 81 ARPGALYIDTSTVSPAASAAVAPLLAARDIAYLRVTVSGNNHMAEAAKLTALVSGPADAY 140
Query: 433 ERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLD 254
ER PLL +G QF+ G ++ KL N+L+ +TG AE + +G K GLE + + D
Sbjct: 141 ERIKPLLAALGPAQFYLGDAEQARLMKLVVNLLIALTGGMLAEALTLGSKGGLEWQAMWD 200
Query: 253 VLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIPL 74
V+ S+ S P+ + +Y F E M+KD+ L + P+ L
Sbjct: 201 VITASAVAS-------PIVKAKAAQLAVHDYTPTFTVEQMLKDVGLILDAGAQLHVPMGL 253
Query: 73 GAVATQLYRIVQSRGYGQKDFSFV 2
A+ Q+ ++G D++ +
Sbjct: 254 TALLGQMLHGAAAQGMAGDDYAAI 277
>UniRef50_Q12H32 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=1; Polaromonas sp. JS666|Rep:
6-phosphogluconate dehydrogenase, NAD-binding precursor
- Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 297
Score = 88.6 bits (210), Expect = 1e-16
Identities = 65/228 (28%), Positives = 105/228 (46%), Gaps = 3/228 (1%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D V+ +T + V G DGV++ A G ++ID+ST +P +++ + E+G+ D
Sbjct: 60 DAVIICVTGSPQVEQTLSGPDGVLSRALAGLIVIDTSTSEPESTRRLAALCAERGVTLVD 119
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
AP++ + A+ L M G + F++ P+L FH G G+G V KL NN +
Sbjct: 120 APLARTPVEAELGRLNTMVGAEQAVFDKIRPVLAAYCENIFHVGGPGAGHVIKLLNNFIG 179
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD-G 155
ATAE +G G+ P+ L++V++ + S GL + N D
Sbjct: 180 QAICTATAEAFAVGALAGINPQKLVEVISAGAVNS----------GLFQAMAKTLNGDFT 229
Query: 154 GFKNEL--MVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQK 17
G K EL KDL + +A + P +G Q + G G+K
Sbjct: 230 GLKFELDNARKDLRYYTHLAEMVNVPSLVGEAVHQSLATASALGQGKK 277
>UniRef50_A1WJN2 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Proteobacteria|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Verminephrobacter eiseniae
(strain EF01-2)
Length = 297
Score = 88.6 bits (210), Expect = 1e-16
Identities = 58/180 (32%), Positives = 88/180 (48%), Gaps = 3/180 (1%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D V L S +V + +DG++A A+ G +++D T + +Q+ + F D
Sbjct: 65 DTVFLSLPSGAIVAQLCRQQDGLLASARPGHIVVDLGTSSVDGTRQLAAEFAARQAKFAD 124
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APV+ AQ TLA M G E F PL+ + CG +G GQV K+ NNM++
Sbjct: 125 APVARTRAAAQAGTLAVMVGADPELFGVIEPLIATFASDIALCGPVGCGQVLKILNNMIL 184
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTE---VYCPVPGLVPTAPSSRNY 161
T +A +E +G K G++ VL D L N SA S++ + +PG P S +Y
Sbjct: 185 FETVVAISEAKAIGEKAGVDASVLFDTLANGSADSFALRNHGMKAVLPGEFPERAFSVHY 244
>UniRef50_A0R1N4 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Mycobacterium|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Mycobacterium smegmatis
(strain ATCC 700084 / mc(2)155)
Length = 272
Score = 88.6 bits (210), Expect = 1e-16
Identities = 50/155 (32%), Positives = 77/155 (49%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V + + V +V G+ GV+A G ++ ST+ P+ +I EKG+ D
Sbjct: 58 DLVCLCVVGDDDVREVLDGETGVLAGLAPGGIIAIHSTVHPDTCTEIAEQVAEKGISLID 117
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG A+ TL MAGG ++ ++ P+ G +GSGQVAK+ NN+L
Sbjct: 118 APVSGGEPAAKAGTLLVMAGGDEDIVDKVRPVFATYADPVVRLGGVGSGQVAKILNNLLF 177
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARS 227
A + +G +G+ L +V+ SA S
Sbjct: 178 SANLGAAMSALELGEALGVPRSALCEVITRGSANS 212
>UniRef50_A1UJF2 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=6; Actinomycetales|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Mycobacterium sp. (strain KMS)
Length = 272
Score = 88.2 bits (209), Expect = 2e-16
Identities = 48/155 (30%), Positives = 76/155 (49%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V + + V +V G GV+A G+++ ST+ P+ ++I A + + D
Sbjct: 58 DLVCVCVVGDDDVREVLYGDTGVLAGLAPGAMIAIHSTVHPDTCREIAEKAAAQNVSVID 117
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG + L M GG + D E++ P+ H G +GSGQV K+ NN+L
Sbjct: 118 APVSGGAPAVEQGKLLVMVGGEEADVEKARPVFATYADPIVHLGPLGSGQVTKILNNLLF 177
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARS 227
+ + +G +G+ L +VLN SA S
Sbjct: 178 TANLGSALSTLELGESLGIPRTQLAEVLNGGSATS 212
>UniRef50_UPI00015B4B33 Cluster: PREDICTED: similar to
3-hydroxyisobutyrate dehydrogenase; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to
3-hydroxyisobutyrate dehydrogenase - Nasonia vitripennis
Length = 512
Score = 87.8 bits (208), Expect = 2e-16
Identities = 59/234 (25%), Positives = 105/234 (44%), Gaps = 4/234 (1%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+ S + + ++ G GV+ ++ + ID + I KG + +
Sbjct: 284 DITFSCVADPQAAKEMVFGNCGVLTEITTDKGYVEMTGIDAETSQDIAEAITAKGARYLE 343
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
A V G + ++ TL +A G ++ F+ MG F+ G++G+ L ++
Sbjct: 344 AQVQGSKVQSEEGTLVILAAGDRQLFDDCNSCFGAMGKNTFYLGEVGNASKMNLVLQLMA 403
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G+T AE M + + GL+ K +L++L T + C P ++ + +GG
Sbjct: 404 GVTLAGLAESMALADRAGLQQKDVLEILE-------LTSLAC--PAILDKGKAI--IEGG 452
Query: 151 FKNEL----MVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F +L M KDL L+ M+ + PIPL A A ++Y+ + GY + D S V
Sbjct: 453 FPTQLPLQHMQKDLRLSLSMSDQLEQPIPLAAAANEIYKHAKRLGYAEHDASAV 506
>UniRef50_UPI0000D55E08 Cluster: PREDICTED: similar to CG4747-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG4747-PA - Tribolium castaneum
Length = 267
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/235 (27%), Positives = 106/235 (45%), Gaps = 5/235 (2%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLL-----IDSSTIDPNVPKQIFPIALEKG 527
DVV S L + +V +G GV+ A+ + L ++ ++IDP+ K I I KG
Sbjct: 33 DVVFSCLADPRSAKEVVIGNCGVIHQAEGPAALAGKGYVEMTSIDPDTSKDICNIIESKG 92
Query: 526 LGFTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLT 347
+ +A + G A++ +L +A G K F+ K +G F+ G +GS L
Sbjct: 93 GRYLEAQMQGSKKQAEDGSLIILAAGDKSLFDDCQTCFKAIGKTAFYLGTVGSATKMNLC 152
Query: 346 NNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSR 167
NM +GI AE M + + GL K L++ N S S Y G + S
Sbjct: 153 INMALGIGLAGLAESMVLAERCGLSCKDFLEIFNLSEGAS----NYLSNKGQLINNRSFS 208
Query: 166 NYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
+ E M KD++L ++ ++ +P+ A A + Y+ + GY + D + V
Sbjct: 209 KVEQAL--EYMQKDIKLCLDISNDVKQNLPVAAAANEAYKTARRSGYDEHDVALV 261
>UniRef50_Q9JYH6 Cluster: 3-hydroxyacid dehydrogenase; n=5;
Proteobacteria|Rep: 3-hydroxyacid dehydrogenase -
Neisseria meningitidis serogroup B
Length = 289
Score = 87.4 bits (207), Expect = 3e-16
Identities = 64/230 (27%), Positives = 104/230 (45%), Gaps = 1/230 (0%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLG-KDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
V+ +++ V D+ G +DG+ G ++++ STI P + + G F +
Sbjct: 65 VIFLMVSDYAAVCDILNGVRDGLA-----GKIIVNMSTISPTENLAVKALVEAAGGQFAE 119
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG V A N TL + GG + + ++G K FH G +G G AKL N L+
Sbjct: 120 APVSGSVGPATNGTLLILFGGSEAVLNPLQKIFSLVGKKTFHFGDVGKGSGAKLVLNSLL 179
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
GI G A +E M M + G++ +++ + S+ S P+ + ++R +
Sbjct: 180 GIFGEAYSEAMLMARQFGIDTDTIVEAIGGSAMDS-------PMFQTKKSLWANREFPPA 232
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F + KDL LA + +P YR GYG++D S V
Sbjct: 233 FALKHASKDLNLAVKELEQAGNTLPAVETVAASYRKAVEAGYGEQDVSGV 282
>UniRef50_Q84H84 Cluster: Putative oxidoreductase; n=1; Arthrobacter
sp. BP2|Rep: Putative oxidoreductase - Arthrobacter sp.
BP2
Length = 278
Score = 87.0 bits (206), Expect = 4e-16
Identities = 52/158 (32%), Positives = 84/158 (53%), Gaps = 2/158 (1%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG-LGFT 515
D +VS++ +DV LG+DG+++ K +I ST+DP+ ++ E G +
Sbjct: 61 DAIVSMVRDYAQNVDVILGQDGLLSANPKNLTIIVMSTLDPDTMNELGQQVEEHGEVRLI 120
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCG-QIGSGQVAKLTNNM 338
A VSGG GA+ TL+ MA G ++ + P +G+ F+ G + G+ Q AKL NN+
Sbjct: 121 AAAVSGGSTGAEAGTLSIMASGAEDVVTAASPYFDAVGSNTFYYGSKPGNSQAAKLVNNL 180
Query: 337 LMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSW 224
++GI A AE + G + L LL++ S+ SW
Sbjct: 181 VLGINMNAVAEGLKFGAQYNLPEAELLNLFKVSTGDSW 218
>UniRef50_A0NRG5 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding protein; n=1; Stappia aggregata IAM
12614|Rep: 6-phosphogluconate dehydrogenase, NAD-binding
protein - Stappia aggregata IAM 12614
Length = 291
Score = 87.0 bits (206), Expect = 4e-16
Identities = 47/153 (30%), Positives = 76/153 (49%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V+++L + VY G DG+ + +L++ T+ + +++ A EKG F D
Sbjct: 59 DIVITMLADDAAAETVYFGPDGLFEASSGAQVLVEMGTLSVPMAERLARAAQEKGRRFVD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG A++A L MAG D L V+G K G+ G+G KL NML+
Sbjct: 119 APVSGATQAAKDAKLLIMAGATASDAPELAALFDVLGRKTIWLGKAGAGAAMKLGVNMLI 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSA 233
AE +++ G+ + +V+ NS+A
Sbjct: 179 HGLNQTLAEALSLTTAAGIPQEQAYEVVENSAA 211
>UniRef50_A0GPK7 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=4; Burkholderia|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Burkholderia phytofirmans
PsJN
Length = 297
Score = 86.6 bits (205), Expect = 5e-16
Identities = 68/228 (29%), Positives = 103/228 (45%), Gaps = 1/228 (0%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEK-GLGFTD 512
+V+ L V V G DG+ A++G+ L+D ST+ P+ + E+ G + D
Sbjct: 64 IVMLCLADAAAVEAVAFGVDGLANRARRGATLVDHSTLAPSQTRAFARRWREQTGGDWID 123
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG GA TLA MAGG E P+L+ A+ G G+GQ KL N ++
Sbjct: 124 APVSGGTSGAAAGTLAIMAGGDATLIETLTPILRGYAARVTRMGGSGAGQATKLANQTIV 183
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
T A AE + G++ + L A S + P +VP A +S G
Sbjct: 184 MTTIAALAEATRLARHAGIDTARIPAALAGGWADSVLLQTLMP-RMIVPPAQAS----GT 238
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
+ M+KDL+ +A + +P+ A+ + +G G D S
Sbjct: 239 IRT--MLKDLDAVESLARESDTTLPVAALVRRWLTQAVEQGLGDADIS 284
>UniRef50_Q2CHC8 Cluster: Oxidoreductase; n=1; Oceanicola granulosus
HTCC2516|Rep: Oxidoreductase - Oceanicola granulosus
HTCC2516
Length = 288
Score = 85.4 bits (202), Expect = 1e-15
Identities = 49/155 (31%), Positives = 77/155 (49%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+VV + + V DV G G+ A A +++D ST+ P + I A + D
Sbjct: 58 DIVVLCVLDGRAVEDVCFGAQGL-AGAGGAEIVVDCSTVPPEATRDI---AGRMDAAWID 113
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG A+ L + GG++ D ER+ ++ + A H G +G+GQ AK N ++
Sbjct: 114 APVSGGPQLAETGELTMLLGGQERDIERARAVIDALAANATHLGPLGAGQAAKTLNQAIV 173
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARS 227
G+ + AE + + K G++P L L A S
Sbjct: 174 GVNYVLMAELLALARKSGIDPARLPQALAGGMADS 208
>UniRef50_Q7NEW9 Cluster: Glr3759 protein; n=3; Bacteria|Rep:
Glr3759 protein - Gloeobacter violaceus
Length = 290
Score = 85.0 bits (201), Expect = 2e-15
Identities = 64/232 (27%), Positives = 104/232 (44%), Gaps = 1/232 (0%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLG-KDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGF 518
VD V ++ + V+L + G +A ++ I+SST+ +++ +G
Sbjct: 58 VDFAVCMVRDDAASRFVWLDFETGALAGLPADAVAIESSTLSVAGVQELAEHFQARGKTL 117
Query: 517 TDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNM 338
DAPVSG A+ L F+ GG ++ P+L MG H G +G+G KL N
Sbjct: 118 LDAPVSGSRPQAEAGQLIFLVGGDAGAVAKAGPILNAMGGTVHHAGPLGNGAAVKLAINA 177
Query: 337 LMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD 158
L+G+ A E + + G++ ++++ ST V P +A + NY
Sbjct: 178 LLGVQVAAMGELIALLRHCGIDEVRAVEIIG-------STSVCSPAARGAASAMAVGNYA 230
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F + LM KDL MA R+ PL A ++ SRGYG+ + + V
Sbjct: 231 PLFPSALMEKDLGYLQNMAAAHRARAPLTQAARSVFGEAMSRGYGEDNMTGV 282
>UniRef50_A0RU56 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Cenarchaeum symbiosum|Rep: 3-hydroxyisobutyrate
dehydrogenase - Cenarchaeum symbiosum
Length = 282
Score = 85.0 bits (201), Expect = 2e-15
Identities = 58/230 (25%), Positives = 103/230 (44%), Gaps = 2/230 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D V++ +T + V G++G+ A K +L D STI+P I + G+ D
Sbjct: 49 DTVITCVTDADALEQVSFGENGIAQGAHKDLVLCDMSTINPEGAVSISKKLADAGIRMVD 108
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APV GG A L MA G K +E +L + K F+ G G+ KL N+ +
Sbjct: 109 APVMGGPGAAMRGELVIMASGDKGAYEERRGILGAVSRKMFYLGGSGTAYSIKLAMNLQI 168
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNS--SARSWSTEVYCPVPGLVPTAPSSRNYD 158
+ ++ +E + + ++P L+VLN++ + + + Y + G +++
Sbjct: 169 AMLAISLSEGITLARGASVDPHKFLEVLNSTYFNTGMSNNKAYKMIEG---------SFE 219
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
F + KDL + A R +PL +A ++Y G+G D++
Sbjct: 220 PSFLLRNLKKDLHTINDHAESSRLKLPLSTLAEEVYSEAVKGGFGDLDYT 269
>UniRef50_Q0QWD5 Cluster: Putative 3-hydroxyisobutyrate
dehydrogenase; n=1; Leptosphaeria maculans|Rep: Putative
3-hydroxyisobutyrate dehydrogenase - Leptosphaeria
maculans (Blackleg fungus)
Length = 296
Score = 84.6 bits (200), Expect = 2e-15
Identities = 48/140 (34%), Positives = 76/140 (54%), Gaps = 6/140 (4%)
Frame = -3
Query: 421 PLLKVMGA-KQFH-CGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVL 248
P L ++G +FH +G+G AK+ NN L G +ATAE + +G + GL+P+ L V+
Sbjct: 125 PTLHMLGPPSKFHYLSTLGAGLTAKIANNYLSGTILLATAEALALGTRHGLDPRALYAVI 184
Query: 247 NNSSARSWSTEVYCPVPGLVPT--APSSRNYDGGFKNELMVKDLELA--SGMALGIRSPI 80
+S+ +SW + CP+P + PS+ Y GF+ E+MVKDL+L S +G+ +
Sbjct: 185 QSSTGQSWMCDHVCPIPNVQTQYWVPSNSGYRPGFRTEMMVKDLDLGVRSAAEVGVEPTM 244
Query: 79 PLGAVATQLYRIVQSRGYGQ 20
A+A V R G+
Sbjct: 245 ARAALAVWERAAVDERCRGR 264
>UniRef50_A7I8V1 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Candidatus Methanoregula boonei
6A8|Rep: 6-phosphogluconate dehydrogenase, NAD-binding -
Methanoregula boonei (strain 6A8)
Length = 288
Score = 84.6 bits (200), Expect = 2e-15
Identities = 54/229 (23%), Positives = 107/229 (46%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VDVV+ L + V V G +G+++ G ++ID++T + A + G +
Sbjct: 58 VDVVLINLFDSDAVESVLSGPEGLLSGPCTGKIIIDTTTNHFGRVSDFYAGARDHGATYL 117
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
+ PV G V+ A L + G + +E PLL +G+ ++ G+ KL NN++
Sbjct: 118 ECPVLGSVVPASQGKLTVLVSGDEGTYEVVKPLLSRIGSTLYYLGEPALATKMKLINNLV 177
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+G AE + +G G++ ++D+L + + S V +R +
Sbjct: 178 LGSFMATCAEAVALGEAAGIDRGEVIDILLSGAGNSM-------VLAAKKDKLKNREFSP 230
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
F + L+ KDL + ++ P+ +G+ +++ + +S+G ++DFS
Sbjct: 231 HFSSALIYKDLHYLQDLCRTLKKPLFVGSTVKEVFALARSKGIDEQDFS 279
>UniRef50_Q20XN2 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Rhodopseudomonas palustris BisB18|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Rhodopseudomonas palustris (strain BisB18)
Length = 365
Score = 83.4 bits (197), Expect = 5e-15
Identities = 66/229 (28%), Positives = 105/229 (45%), Gaps = 1/229 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV S L ++ V V G G+V K G++ I STI P + +++ E G G+
Sbjct: 77 DVVFSSLPDDEAVTAVAAGAGGLVKIMKAGAVHISMSTISPTMSRRLAAWHGECGQGYVA 136
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQ-IGSGQVAKLTNNML 335
APV G A+ TL +A G +++ PLL +G K F G+ + + KL N+L
Sbjct: 137 APVLGNPDLARARTLFILAAGPDAAMQKARPLLDRLGQKLFVIGEDAAAANLVKLAGNVL 196
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+T + E + + K G++P+V D+ NS + + V+ G + R
Sbjct: 197 TALTLQSMGEVLALLRKSGIDPRVGFDIFTNS---LFDSRVHRTYGGKI---VDERYSPP 250
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
G L VKDL LA A P+P ++ + + G+ D+S
Sbjct: 251 GMTVPLAVKDLRLALAEAETNSVPMPATSLVRDRLVAMVAHGWADLDWS 299
>UniRef50_Q4WV01 Cluster: Oxidoreductase, acting on the CH-OH group
of donors, NAD or NADP as acceptor; n=7;
Pezizomycotina|Rep: Oxidoreductase, acting on the CH-OH
group of donors, NAD or NADP as acceptor - Aspergillus
fumigatus (Sartorya fumigata)
Length = 435
Score = 83.4 bits (197), Expect = 5e-15
Identities = 65/234 (27%), Positives = 103/234 (44%), Gaps = 6/234 (2%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG---LG 521
D + ++ S V V G DGVV K + L ST+ + + + +G +
Sbjct: 61 DFYICMVASAPQVQSVLFGDDGVVQFLPKNATLFLCSTVPASYAQSVAAELQSRGRADIR 120
Query: 520 FTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQ---FHCGQIGSGQVAKL 350
F D PVSGG A + TL+ MAG +E +L+VM + G +G+G K+
Sbjct: 121 FIDCPVSGGAKRAADGTLSIMAGASEEALNSGREILQVMSDQNKLYLVPGGVGAGSNMKM 180
Query: 349 TNNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSS 170
+ +L GI + +E M ++GL+ K + + S A +W E L
Sbjct: 181 VHQVLAGIHILGASEAMGFAAQLGLDAKTTAEKIIGSEAWTWMHE-----NRLQRMVEED 235
Query: 169 RNYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
N G +++KD+ + + A P PL + A Q+Y +GYG KD S
Sbjct: 236 WN-PGASALTIILKDVGIITTSARQHHFPTPLCSTAEQVYLSALLQGYGPKDDS 288
>UniRef50_A1CAY2 Cluster: Oxidoreductase, acting on the CH-OH group
of donors, NAD or NADP as acceptor; n=2;
Aspergillus|Rep: Oxidoreductase, acting on the CH-OH
group of donors, NAD or NADP as acceptor - Aspergillus
clavatus
Length = 436
Score = 83.4 bits (197), Expect = 5e-15
Identities = 64/234 (27%), Positives = 105/234 (44%), Gaps = 6/234 (2%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG---LG 521
D V ++ S V V G DG+V + + L ST+ + + + G +
Sbjct: 61 DFYVCMVASAPQVQSVLFGDDGIVQYLPPNATLFLCSTVPASYAQSVAAELQSLGRADIR 120
Query: 520 FTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMG-AKQFHC--GQIGSGQVAKL 350
F D PVSGG A + TL+ MAG +E +L+VM K+ + G IG+G K+
Sbjct: 121 FIDCPVSGGAKRAADGTLSIMAGAPEEALNSGREILQVMSDQKKLYLVPGGIGAGSNMKM 180
Query: 349 TNNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSS 170
+ +L GI + +E M ++GL+ K + + A +W E +P +
Sbjct: 181 VHQVLAGIHILGASEAMGFAAQLGLDAKTTAAKIIGTEAWTWMHE------NRLPRMLAE 234
Query: 169 RNYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
G +++KD+ + + A P+PL + A Q+Y +GYG KD S
Sbjct: 235 DWNPGASALTIILKDVGIITTSARQHHFPVPLCSTAEQVYLSALLQGYGAKDDS 288
>UniRef50_Q1EPJ1 Cluster: 6-phosphogluconate dehydrogenase
NAD-binding domain-containing protein; n=8;
Magnoliophyta|Rep: 6-phosphogluconate dehydrogenase
NAD-binding domain-containing protein - Musa acuminata
(Banana)
Length = 314
Score = 83.0 bits (196), Expect = 6e-15
Identities = 64/210 (30%), Positives = 101/210 (48%), Gaps = 7/210 (3%)
Frame = -3
Query: 628 GVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGG 449
G +A G +L+D ++ DP + +++ A +G DAPVSGG +GA++ TLA +AGG
Sbjct: 95 GALAAIPPGGVLVDCTSSDPALAREVAAAARARGCWAVDAPVSGGDVGARDGTLAILAGG 154
Query: 448 RKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEP 269
+ PL + +G + G GSGQ +K+ N + +G T + +E + + GL+
Sbjct: 155 DEGVVHWLSPLFEALGRATW-MGPAGSGQSSKIANQITIGGTILGLSEAIVFAGRAGLDV 213
Query: 268 KVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDL-------ELAS 110
LD + +A S + E++ AP GGF E MVKDL E
Sbjct: 214 PRFLDAVRGGAAGSRAMEIFGERMARRDFAP------GGFA-EYMVKDLGMGLRGGEDGG 266
Query: 109 GMALGIRSPIPLGAVATQLYRIVQSRGYGQ 20
G +P A+ QLY + + G G+
Sbjct: 267 EEETGKGVVLPGAALCQQLYLAMVANGDGK 296
>UniRef50_Q3W3N3 Cluster: Putative uncharacterized protein; n=1;
Frankia sp. EAN1pec|Rep: Putative uncharacterized
protein - Frankia sp. EAN1pec
Length = 315
Score = 82.2 bits (194), Expect = 1e-14
Identities = 57/193 (29%), Positives = 85/193 (44%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
V V + S++ V V G G++ + GSL++ ST P + A +G+
Sbjct: 70 VTVASVCVYSDEDVRTVVAGPGGLLETMRSGSLVVIHSTCSPRTCVDLAARARGRGITVL 129
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPVS G L +AGG + D +R P+ ++ G + G +GS Q+ KL NN L
Sbjct: 130 DAPVSNGAPDESGRQLVVLAGGDRRDVDRCAPVFELFGRTVVYTGDVGSAQLTKLVNNAL 189
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+ A E + +GL+P + L SA + S P+PG P
Sbjct: 190 FIVHRSAAIEALRAAGTLGLDPDGVRVALQECSANARS----LPIPGGPPIGGHGGPPPD 245
Query: 154 GFKNELMVKDLEL 116
F L+ KDL L
Sbjct: 246 AFV-ALLTKDLNL 257
>UniRef50_Q3W9L4 Cluster: Putative uncharacterized protein; n=1;
Frankia sp. EAN1pec|Rep: Putative uncharacterized
protein - Frankia sp. EAN1pec
Length = 294
Score = 81.8 bits (193), Expect = 1e-14
Identities = 49/152 (32%), Positives = 73/152 (48%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV + ++ V DV L DGV+A G +++ STI P +++ A ++ + D
Sbjct: 72 DVVGICVVADADVEDVLLRADGVLAGMAAGGVVVIHSTIRPETCQRLATEAAKQEISIID 131
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG A L M GG + R P+L+ H G +GSGQVAKL NN +
Sbjct: 132 APVSGGGDAAAQRRLLVMVGGEDDAVARCRPVLETFACPVIHLGPLGSGQVAKLVNNFVF 191
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSS 236
E + ++G++ VL + S
Sbjct: 192 TAQVGLALETFSFAQRLGMDRAAAAQVLAHGS 223
>UniRef50_Q8UBW3 Cluster: Oxidoredutase; n=1; Agrobacterium
tumefaciens str. C58|Rep: Oxidoredutase - Agrobacterium
tumefaciens (strain C58 / ATCC 33970)
Length = 300
Score = 81.0 bits (191), Expect = 3e-14
Identities = 63/212 (29%), Positives = 100/212 (47%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V+++L+ V +V L + GV KG+++IDSS+I P + ++ G+ D
Sbjct: 67 DIVITMLSDGNAVGEV-LFEAGVAEALAKGAVVIDSSSIAPPIAREHSSRLQAMGIHHVD 125
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGGV GA TLA MAGG + + + MG + + G G+GQ+ KL N ++
Sbjct: 126 APVSGGVPGATAGTLAIMAGGDEALISGLVDVFAPMG-RLTYVGPSGAGQLCKLANQQIV 184
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
IT A AE M + G + + + A S E++ RN+ G
Sbjct: 185 AITIGAVAEAMMLVEAGGASREGFRNAIRGGFAESRILELH-------GERMVKRNFVPG 237
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQ 56
++ +KDL A + +PL T+
Sbjct: 238 GPSKFQLKDLNGVLATAKDLALTLPLTQQVTR 269
>UniRef50_A5WG80 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Moraxellaceae|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Psychrobacter sp. PRwf-1
Length = 309
Score = 81.0 bits (191), Expect = 3e-14
Identities = 64/229 (27%), Positives = 99/229 (43%), Gaps = 1/229 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV+ S L +++VV D+ + + H GS+ +D ++ P K G F D
Sbjct: 72 DVIFSCLPTSQVVDDLI---EQALPHLNDGSVWVDCTSGVPENAKASQAKLNAAGCEFLD 128
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG GA + TL M GG + + + H G G+G K NN L
Sbjct: 129 APVSGQTSGADSGTLTVMVGGSAKALAYAKSAIDCFAGLIVHVGDSGAGFAVKAVNNTLF 188
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
I A E +++ G+ P L +N +S +S++T V +P ++ Y
Sbjct: 189 AINAWAAVEGLSVLKAHGVNPSDALACINKASGQSFATLV------TLPDRIVNQTYPKT 242
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSR-GYGQKDFS 8
F +LM KD +A + + P P+ A L R ++ G DFS
Sbjct: 243 FTIDLMAKDCGIAIDLQTEKQVPTPVMAQVASLVRAASNQYEPGSADFS 291
>UniRef50_UPI0001597301 Cluster: YfjR; n=1; Bacillus
amyloliquefaciens FZB42|Rep: YfjR - Bacillus
amyloliquefaciens FZB42
Length = 286
Score = 80.6 bits (190), Expect = 3e-14
Identities = 64/230 (27%), Positives = 109/230 (47%), Gaps = 2/230 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V+S+L+ + V DV G G++A + + I STI + +Q+ +G F
Sbjct: 58 DIVLSMLSDDDAVTDVTFGACGIIAGLSENGIHISMSTISTALSEQLSAAHSGRGQSFIA 117
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCG-QIGSGQVAKLTNNML 335
APV G A+ A L + G E +++ PLL ++ + F G + + AK++ N L
Sbjct: 118 APVLGRPDAAEKAELRIITAGPAEAKKKAEPLLNILSQQVFDTGEETKTANAAKISVNFL 177
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD- 158
+ A +E M K GLE K L++ + A S PV T + + ++
Sbjct: 178 LVSMLEALSESFLMMEKYGLEQKQFLEI---AGALFGS-----PVYQNYGTMMAEQKFEP 229
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
GFK L +KD LA A + + +PL +A + ++G+G D++
Sbjct: 230 AGFKMSLGLKDTNLALAAAEQVSAKLPLAELAKSHFESGIAQGFGDLDWA 279
>UniRef50_A4ECY9 Cluster: Putative uncharacterized protein; n=1;
Collinsella aerofaciens ATCC 25986|Rep: Putative
uncharacterized protein - Collinsella aerofaciens ATCC
25986
Length = 359
Score = 80.6 bits (190), Expect = 3e-14
Identities = 63/221 (28%), Positives = 97/221 (43%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV +++ V ++YL DG++ K G++LID +T P + + I A G D
Sbjct: 62 DVVFTMVGYPSEVEELYLAGDGLLTCTKPGAVLIDLTTSSPELARDIAEAAQVSGRMAFD 121
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
PV+GG GA TL + G + D +L A G GQ AKL N + +
Sbjct: 122 CPVTGGESGAIAGTLTAIVGATENDIAPVRDVLSTFAANICCFDGAGKGQAAKLANQVSL 181
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ A+ M GL+ + +++ + +S + E L P A +Y G
Sbjct: 182 AACMVGMADAMAFAELSGLDLEKTREMILGGTGKSGAME------SLAPKALDG-DYKPG 234
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRG 29
F E +KDL LA A +P VA LY ++ + G
Sbjct: 235 FMVEHFIKDLRLALAYADDRELALPGADVAFTLYDMLDAIG 275
>UniRef50_Q7NR40 Cluster: Probable 3-hydroxyisobutyrate
dehydrogenase; n=1; Chromobacterium violaceum|Rep:
Probable 3-hydroxyisobutyrate dehydrogenase -
Chromobacterium violaceum
Length = 296
Score = 80.2 bits (189), Expect = 4e-14
Identities = 47/155 (30%), Positives = 73/155 (47%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D V ++LT + + + G +G+ + G L+D T P + A G +
Sbjct: 65 DWVATVLTDSAALRALLFGDNGIASAPAAGRRLVDLGTHQPTQLAALGAEAAAAGWPLVE 124
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
AP++G V A + TL F+ GG + D E + PLL +G H G +G+G AKL N+L+
Sbjct: 125 APMTGSVHDASHGTLHFLVGGAEADVEWASPLLWALGRGVHHLGGLGAGNTAKLALNLLV 184
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARS 227
G+ E + + GL LD L+ S S
Sbjct: 185 GVMAGGLGEAIALLRAHGLAVDSFLDALDGSGLAS 219
>UniRef50_Q9RX16 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=6;
Bacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Deinococcus radiodurans
Length = 310
Score = 79.8 bits (188), Expect = 6e-14
Identities = 55/190 (28%), Positives = 89/190 (46%)
Frame = -3
Query: 616 HAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKED 437
H + G++ +D ++ P+ ++ G+ F DAPVSGG GA+ TL M GG ++
Sbjct: 100 HLRPGTVWVDCTSGHPDAARRQRETLDALGVKFLDAPVSGGTSGAEAGTLTVMLGGPADE 159
Query: 436 FERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLL 257
+ + P L G K G+ G+G K NNML+ + A E + + G++ L
Sbjct: 160 IDAASPHLAFAG-KVVRVGETGAGFAVKAVNNMLLAVNLWAAGEGLAALGRSGVDLGAAL 218
Query: 256 DVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIP 77
V+N SS RS ++E L+P +R + F L+ KD +A + ++ P
Sbjct: 219 SVINASSGRSNASE------NLIPQRVLTREFPVTFALGLLAKDTGIALDVVQSAKASAP 272
Query: 76 LGAVATQLYR 47
A L R
Sbjct: 273 TLAQVAGLIR 282
>UniRef50_Q8F4I7 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=4;
Leptospira|Rep: 3-hydroxyisobutyrate dehydrogenase -
Leptospira interrogans
Length = 296
Score = 79.8 bits (188), Expect = 6e-14
Identities = 60/227 (26%), Positives = 106/227 (46%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+VV LT +++V + G++ K +LID T ++ ++ + EK + F D
Sbjct: 62 DLVVLCLTEDQIVEKETISS-GLLD--TKPPILIDCGTTSLSLTLKLSKLCSEKKIRFYD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
+P++G A++ + FM G ++ D + +V G +CG IG GQ AKL NM+
Sbjct: 119 SPMTGSKNAARDGQILFMIGAKQVDIKDIQFFFEVCGKNAVYCGSIGGGQKAKLALNMIQ 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
E + L+P +L ++L S+A+S E P S +Y+
Sbjct: 179 AGIFQVYMEGFELAKNSELDPSILKEILLQSAAKSGIAEFKFPY-------VFSGDYETH 231
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDF 11
F + M KD+ A +A ++ + L ++Y + + GY + DF
Sbjct: 232 FSLKNMRKDVYHAIELAKENKTNLSLCKNLPEIYDLGMNAGYAENDF 278
>UniRef50_Q0BTJ3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=1;
Granulibacter bethesdensis CGDNIH1|Rep:
2-hydroxy-3-oxopropionate reductase - Granulobacter
bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Length = 293
Score = 79.8 bits (188), Expect = 6e-14
Identities = 64/224 (28%), Positives = 98/224 (43%)
Frame = -3
Query: 685 VVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 506
V ++ S+ D L V A+ G++L+ SS Q ++ + DAP
Sbjct: 62 VALLMVSDGPACDAVLETGFVDTMAQNGTVLVMSSIEPWRARAQAKKVSPRF---YVDAP 118
Query: 505 VSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGI 326
VSGG GA+N TLA MAGG + R P+ +G + G IG+GQ+AKL N +++G+
Sbjct: 119 VSGGEGGARNGTLAIMAGGEEAVLNRLAPVFAALG-RMTRIGDIGAGQLAKLANQLIVGV 177
Query: 325 TGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFK 146
T A +E + G P D + A S + N+ G K
Sbjct: 178 TIGAVSEAFVLAEAGGASPARFRDAVAGGFADSRILREH-------GQRMLDENFVPGGK 230
Query: 145 NELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
+ + +KDL + A + +P+ A LYR + G G D
Sbjct: 231 SAIQLKDLRMILQEAKMLGLSLPMTEAAAALYRALCEAGDGDLD 274
>UniRef50_A0QZR7 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Mycobacterium smegmatis str. MC2 155|Rep:
3-hydroxyisobutyrate dehydrogenase - Mycobacterium
smegmatis (strain ATCC 700084 / mc(2)155)
Length = 299
Score = 79.8 bits (188), Expect = 6e-14
Identities = 57/197 (28%), Positives = 89/197 (45%), Gaps = 1/197 (0%)
Frame = -3
Query: 601 SLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDFERSL 422
+++++ ST+ + G G DAPVSGG GA+ +L MA G E+
Sbjct: 89 TVVVNLSTVGRQALTEAADALTHAGYGCLDAPVSGGAEGARTGSLTIMASGDPTTIEQCS 148
Query: 421 PLLKVMGAKQFHCG-QIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVLN 245
+ V+ K G Q G Q K+ NN+L +ATAE + K G+ L+ LN
Sbjct: 149 SVFDVIAGKVIVVGNQPGQAQAIKVANNVLSLGALVATAEATAITRKAGIPLDTALEALN 208
Query: 244 NSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIPLGAV 65
SS R+ +T V P L + +D GF +KD+ L +A + PL +
Sbjct: 209 ASSGRNTATAVKFPRHVL------TGRFDFGFPTSGALKDVSLFLELAAELGVEAPLSSA 262
Query: 64 ATQLYRIVQSRGYGQKD 14
++ +G+GQ+D
Sbjct: 263 VQAIWHTAAEQGFGQQD 279
>UniRef50_Q5LQR0 Cluster: 6-phosphogluconate dehydrogenase domain
protein; n=14; Proteobacteria|Rep: 6-phosphogluconate
dehydrogenase domain protein - Silicibacter pomeroyi
Length = 302
Score = 79.0 bits (186), Expect = 1e-13
Identities = 48/147 (32%), Positives = 74/147 (50%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
V++ + TS +V +Y G DGV+A ++G ++ID T P ++I KG + DA
Sbjct: 69 VMLCMGTSAQVESRIY-GDDGVLAGTREGQVVIDFGTSLPASTRRIGGDLAGKGATYLDA 127
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
P+ A++ L M G K F+R P+L +G FH G +G+G KL NN
Sbjct: 128 PLGRTPAHARDGLLNIMCSGDKATFDRVKPVLHTLGENVFHLGALGNGHTIKLINNCYSM 187
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVL 248
T A AE + G+E + L +V+
Sbjct: 188 TTACAMAEAFAIADATGIERQALYNVM 214
>UniRef50_A5P600 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Methylobacterium sp. 4-46|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Methylobacterium sp. 4-46
Length = 290
Score = 79.0 bits (186), Expect = 1e-13
Identities = 64/218 (29%), Positives = 102/218 (46%), Gaps = 5/218 (2%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
VVV+ L + + V LG +G++A +L+++ST+ P + A G+ + A
Sbjct: 55 VVVTSLPDDAALAAVALGPEGLLARMAPDGVLVETSTVSPETSAALREAAEAGGILYLAA 114
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVA---KLTNNM 338
PVSG A+ ATL G + ER+ PLL A+ H +G G+ A KL N
Sbjct: 115 PVSGSTATAEAATLTLFCSGPETALERARPLLATF-ARTIHA--VGPGEEARFLKLAINH 171
Query: 337 LMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD 158
+G T AE + + + G+ +L VL +S A S P+ R++
Sbjct: 172 FVGSTAQVAAEALTLARRGGVAWDTVLAVLGSSVAAS-------PLVAYKLDPLRRRDFS 224
Query: 157 GGFKNELMVKDLEL--ASGMALGIRSPIPLGAVATQLY 50
F M+KD+ L A+G A+G+ +P+ A+ LY
Sbjct: 225 PAFSIAQMLKDMSLGVAAGEAVGV--AMPVAALVRDLY 260
>UniRef50_Q4Q9Z1 Cluster: Dehydrogenase-like protein; n=6;
Trypanosomatidae|Rep: Dehydrogenase-like protein -
Leishmania major
Length = 431
Score = 79.0 bits (186), Expect = 1e-13
Identities = 53/185 (28%), Positives = 87/185 (47%), Gaps = 1/185 (0%)
Frame = -3
Query: 667 SNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVM 488
S KV+L+ + +V +A+ G +++D +T+D + ++ A +G F DAP+SG
Sbjct: 88 SRKVLLE---DSEALVTNARPGQIIVDHTTVDMELSRECAHEAERRGAVFLDAPMSGSPK 144
Query: 487 GAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATA 308
A N L M GG E +R P+ ++ H G GSG AKL + L+ A A
Sbjct: 145 QAFNNQLVLMVGGPAEQVQRVSPIFRMYADHIHHMGANGSGTAAKLLSQALVASHNAAAA 204
Query: 307 ECMNMGIKMGLEP-KVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMV 131
E M + ++G+E + L+ VL+ S S P + P G + ++
Sbjct: 205 EAMTIANRLGIEDYQKLIQVLDASWGSSTMLRRNAPTMQDLVRNPDKLAPSSGASIDNLL 264
Query: 130 KDLEL 116
+DL L
Sbjct: 265 EDLAL 269
>UniRef50_Q1B326 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding protein precursor; n=7; Bacteria|Rep:
6-phosphogluconate dehydrogenase, NAD-binding protein
precursor - Mycobacterium sp. (strain MCS)
Length = 299
Score = 78.2 bits (184), Expect = 2e-13
Identities = 60/232 (25%), Positives = 110/232 (47%), Gaps = 2/232 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVVV++L ++ V V G DG+VA + ++ + SSTI + +++ E G F
Sbjct: 60 DVVVTMLANDDAVEAVSFGDDGIVASLRPDAIHVSSSTISLALAERLTAAHAEGGSRFVS 119
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCG-QIGSGQVAKLTNNML 335
APV G A A L +A G + E P+ + +G + F G + + + K++ N L
Sbjct: 120 APVFGRPEAAAAAKLFVVAAGAPDTVEALAPVFEAIGQRTFVVGTEPKAANLVKVSGNFL 179
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD- 158
+ + E M + K G++ LD+L ++ + Y GL+ + R ++
Sbjct: 180 IASVIESLGEAMALVAKGGVDVDQYLDLLTST---LFDAPAYRTYGGLL----ARREFEP 232
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
GF +KD+ LA G++ P+P+ ++ + + + G G D+S +
Sbjct: 233 AGFSATGGLKDVRLALEAGDGLQVPLPIASLLRDRFLTLLATGGGHLDWSAI 284
>UniRef50_A7DWL2 Cluster: Putative dehydrogenase; n=1; Streptomyces
tendae|Rep: Putative dehydrogenase - Streptomyces tendae
Length = 293
Score = 77.8 bits (183), Expect = 2e-13
Identities = 65/230 (28%), Positives = 98/230 (42%), Gaps = 1/230 (0%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
VV+ L V +V G+ VV + G++L+D++T+ P+ + G+ +A
Sbjct: 61 VVLLSLADEPAVDEVLFGE--VVWQLQPGTVLVDTTTVSPSFARNTAVRLAASGVERLEA 118
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
V G A++ L G + + +L +G + H G G KL N+L+G
Sbjct: 119 CVMGNPEMAESGRLRIFTSGSHSAVDAAGDVLSALGQEVRHLGDAGRASALKLALNLLLG 178
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNY-DGG 152
I AE + GL +LL+VL S RS PV G R Y
Sbjct: 179 IQTAGLAEAVAFAEAAGLGRDLLLEVLLGSGWRS-------PVLGFRAEFMRRRTYTPAA 231
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F+ LM KDLELA A + P+PL A + + G G +D + V
Sbjct: 232 FRTRLMHKDLELALDQATAYQLPLPLVHRAQERFAGAIDAGRGDEDAAVV 281
>UniRef50_A6VLT0 Cluster: 2-hydroxy-3-oxopropionate reductase; n=2;
Pasteurellaceae|Rep: 2-hydroxy-3-oxopropionate reductase
- Actinobacillus succinogenes 130Z
Length = 289
Score = 77.8 bits (183), Expect = 2e-13
Identities = 55/228 (24%), Positives = 101/228 (44%)
Frame = -3
Query: 685 VVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 506
V+ ++ ++ V++ L ++ V A KG L+++ ST+ P +Q+ + + G F +AP
Sbjct: 65 VIFVMVADFPVIESLLSEE--VLTALKGKLVVNMSTVSPTQNQQLEFLLAKHGAEFIEAP 122
Query: 505 VSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGI 326
VSG A+ L +A G++E E+ PL + F+ G++G KL N L+GI
Sbjct: 123 VSGSSKVAEAGKLLVLAAGKEEIVEQLKPLFAAFSTQTFYYGEVGKAGGVKLMINSLLGI 182
Query: 325 TGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFK 146
A E + + G+ ++++++ S S + P+ ++ F
Sbjct: 183 FIQAYGEALLFAEQFGIPKDQVIEMISGSFMNSQIFQAKVPM-------YRQNDFSPAFM 235
Query: 145 NELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
+ M KD LA + PL AT Y G + D + +
Sbjct: 236 MKHMTKDFNLAKSEIAKMGKAFPLIQQATVSYNQANQSGLSEVDMAAI 283
>UniRef50_A0JRK4 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=3; Actinomycetales|Rep:
6-phosphogluconate dehydrogenase, NAD-binding precursor
- Arthrobacter sp. (strain FB24)
Length = 299
Score = 77.8 bits (183), Expect = 2e-13
Identities = 61/232 (26%), Positives = 108/232 (46%), Gaps = 2/232 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPN-VPKQIFPIALEKGLGFT 515
D ++ + + + + DV G +GV + K G+++I ST+ + +P + +A E G+
Sbjct: 61 DALLLAVRNGEQLNDVLFGANGVASVLKPGAVVILGSTVGTDAIPATVDRLA-EYGVELV 119
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCG-QIGSGQVAKLTNNM 338
DAP+SGG A L + G E E++ P L+++ + G + G GQ K N +
Sbjct: 120 DAPLSGGPKRAGEGDLLIVVGASPEAQEKARPALELLASTLTVVGDKPGDGQALKTVNQL 179
Query: 337 LMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD 158
L G+ A AE + + +GL+ + L L +A S+ P + A + +
Sbjct: 180 LCGVHIAAAAEALALADALGLDQEKTLKALEAGAAGSFMLSNRGP---RILEAYNEGGAE 236
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
+ ++ VKD+ + P+ A A QLY + Q++G D S V
Sbjct: 237 VLSRLDIFVKDMGIVGKATRAAGLAAPVAAAAEQLYLLGQAQGLAAADDSAV 288
>UniRef50_A7RG59 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 341
Score = 77.4 bits (182), Expect = 3e-13
Identities = 61/225 (27%), Positives = 104/225 (46%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VDV+++ L + V L G+++ K+GS+ ID +T D N ++ +A KG+
Sbjct: 83 VDVLITALPKPQHVKSA-LEDTGMLSMLKEGSVWIDHTTTDYNETIRLGELATSKGVHAV 141
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
+AP++GG + GG ++ + PL+ A + G +G VAK+ +NML
Sbjct: 142 EAPLTGG-----QGLMTVFVGGEEKVVQDVKPLMDSYTATFLYFGPLGKATVAKVISNML 196
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+A E + + K GL+ D + S+ S+ E P+ + +YD
Sbjct: 197 CAAHLVAAGEALMLAKKAGLDMSNFFDGIRYSAGNSYVFETEVPL-------MFNGSYDP 249
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQ 20
F +L KDL L +A SP+ L + +YR + YG+
Sbjct: 250 DFTIDLHCKDLALGREIATSNDSPLELLGLTEDIYRRAMEK-YGK 293
>UniRef50_A7H7Z5 Cluster: 6-phosphogluconate dehydrogenase
NAD-binding; n=2; Anaeromyxobacter|Rep:
6-phosphogluconate dehydrogenase NAD-binding -
Anaeromyxobacter sp. Fw109-5
Length = 293
Score = 77.0 bits (181), Expect = 4e-13
Identities = 60/230 (26%), Positives = 97/230 (42%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V++ ++ K + V G DGV+ + G +L+D ST + + A +G GF
Sbjct: 60 DLVITCVSDEKALDTVLEGPDGVLEALRDGDVLVDMSTAGVRAARSVSERAAARGAGFVA 119
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
PV G A+ A L +AGG ER+ P L + A+ F + KL N +
Sbjct: 120 CPVLGSRSAAEQAQLVLVAGGPAVARERARPALHAVSARIFELEDAAQAALMKLCVNAIG 179
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
G E + +G G+ L++VL A S+ + +Y LV R++
Sbjct: 180 GAMITGFGEALALGQAGGVPVAKLVEVL---QASSFHSPLYLMKGELV----ERRDWAPR 232
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F L KD LA A + + P+ +++ G KD + V
Sbjct: 233 FAIALAEKDQRLAQEAAADLGAKTPVNDTVRRVFADAAQSGRADKDIAAV 282
>UniRef50_A1SQ87 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=4; Bacteria|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Nocardioides sp. (strain
BAA-499 / JS614)
Length = 318
Score = 77.0 bits (181), Expect = 4e-13
Identities = 58/231 (25%), Positives = 108/231 (46%), Gaps = 1/231 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAH-AKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
DVV +++++ + V +G+ G++A A+ ++++D ST+ + E+G+ F
Sbjct: 67 DVVFTMVSTPADLEQVLVGEGGLLADPARVPAVVVDCSTVSTESSAAMRAACSERGVAFL 126
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
APVSG + L+ + G +E +ER LL +G + G+ ++AK+ +N++
Sbjct: 127 AAPVSGNGKVVRAGGLSLVVSGPEETYERVAHLLDHLGKGATYVGEGELARLAKICHNVM 186
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+G+ AE + K G+ L+ LN S S T P A + +Y
Sbjct: 187 LGVVTQCLAEITVLAEKGGMSRAAFLEFLNKSVMGSVFTTYKTP-------AFVNLDYTP 239
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F L+ KD +L A + P+P+ A + S G ++DF+ +
Sbjct: 240 TFTPILLRKDFDLGLAAARQLDVPMPVAAATNAAVQASVSSGRVEEDFAIL 290
>UniRef50_Q89M84 Cluster: Blr4309 protein; n=6;
Bradyrhizobiaceae|Rep: Blr4309 protein - Bradyrhizobium
japonicum
Length = 293
Score = 76.6 bits (180), Expect = 5e-13
Identities = 46/155 (29%), Positives = 79/155 (50%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D VV+++ ++ V+LG G AK G++ I+ ST+ + +++ +GL + D
Sbjct: 59 DAVVTMVADDEASRAVWLGPKGAAKTAKAGTIAIECSTVSYDHAREMGRELNARGLIYID 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
PV+G A L + G D ER+ P L+ +G+ H G +GSG V KL NN++
Sbjct: 119 CPVTGLPDAAAAGKLTLLVGADAADLERARPYLEPIGSTIRHFGAVGSGTVYKLINNLMG 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARS 227
I AE + + + GL+ ++L+ + A S
Sbjct: 179 AIQIAGLAEGLAIAEQAGLDMTLVLESIQAGVAAS 213
>UniRef50_A3ET09 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3;
Bacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Leptospirillum sp. Group II UBA
Length = 311
Score = 76.6 bits (180), Expect = 5e-13
Identities = 55/230 (23%), Positives = 106/230 (46%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV+++++ +++ + ++ + G + ++ +T+ P++ ++ + ++G +
Sbjct: 68 DVIITVVGTDREMDALFAETGDSLLVGASGRVFVNCATLSPDIHVEVERRSNDRGADCLE 127
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
A ++ + A+ TL M GG+KE FER P+L+ M A G G K NM+M
Sbjct: 128 ASMASSITQAREGTLYLMVGGKKEAFERVRPVLEAMSASLRWIGPAGQAAKIKALVNMVM 187
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
I AE + + +GL+ ++ +V + + A S E G +R +D
Sbjct: 188 NINTAGLAEGLGLADALGLDLAMVREVFSQTGAASRVLE----TDG---ADMQNREHDVY 240
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F KD +A +A + +PL A+ Y + S G G+ D S V
Sbjct: 241 FSAAHAAKDSRIALALAARVGLNLPLAKAASGQYDRMVSLGLGEIDKSGV 290
>UniRef50_A3Y8R5 Cluster: Putative dehydrogenase; n=1; Marinomonas
sp. MED121|Rep: Putative dehydrogenase - Marinomonas sp.
MED121
Length = 297
Score = 76.2 bits (179), Expect = 7e-13
Identities = 58/202 (28%), Positives = 92/202 (45%), Gaps = 2/202 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV+ + L S+ V + G++G++ +A+ G+ ++ST + + +++ IA L D
Sbjct: 62 DVIFTSLPSSVQVNHIAFGEEGILENAQAGATWFETSTNELSEWEKVKAIA-PSHLSLID 120
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APV+GG GA TL + G ++ + +L G G+G V KL L
Sbjct: 121 APVTGGAEGAAAGTLTMLLGIDEQILTKFTSMLNAFTKNAIRMGPSGAGYVTKLAQLHLN 180
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ E + MG K L VL +L NS A+S+ + Y P +YD
Sbjct: 181 YLVAQGIGEALMMGAKAELNLDVLHKILQNSCAQSYVVDSYIP-------KVLDGSYDQS 233
Query: 151 FKNELMVKDLELAS--GMALGI 92
F L KD+ L + G LGI
Sbjct: 234 FALGLATKDMRLITELGSHLGI 255
>UniRef50_Q5LNV6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Rhodobacteraceae|Rep: 3-hydroxyisobutyrate dehydrogenase
- Silicibacter pomeroyi
Length = 269
Score = 75.8 bits (178), Expect = 1e-12
Identities = 43/136 (31%), Positives = 66/136 (48%)
Frame = -3
Query: 631 DGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAG 452
D + HAK +I ST+ P + + + + DAP+SG + AQ A L+FM G
Sbjct: 74 DQKLIHAKHLDCVIICSTLSPRYVRDL-RARVPDHIALIDAPMSGAQIAAQEARLSFMLG 132
Query: 451 GRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLE 272
G D + + PL MG+ G GSG AK+ NN+L T ++ GL+
Sbjct: 133 GEPADLDAAQPLFAAMGSHFHRMGPYGSGMQAKVLNNLLAAANTAMTRLVLDWADAAGLD 192
Query: 271 PKVLLDVLNNSSARSW 224
LL +++ SS ++W
Sbjct: 193 EVALLRLIHTSSGQNW 208
>UniRef50_Q3WJ00 Cluster: 6-phosphogluconate dehydrogenase, NAD
binding domain; n=1; Frankia sp. EAN1pec|Rep:
6-phosphogluconate dehydrogenase, NAD binding domain -
Frankia sp. EAN1pec
Length = 438
Score = 75.4 bits (177), Expect = 1e-12
Identities = 59/199 (29%), Positives = 82/199 (41%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VD V + V +V G DG+ G++++ ST+ P ++I A GL
Sbjct: 226 VDAVGICVFDAAGVEEVMFGPDGLAGTLNPGAVVLVHSTVAPAQIRRIAGRAATHGLRVL 285
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAPVSGG A L M GG + LL + H G +G+G AKL NN +
Sbjct: 286 DAPVSGGQPRALAGELTIMIGGDADTLADVAELLSALSNHVVHLGAVGAGSYAKLINNTM 345
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+ M G +G++P L VL SS+ ++ V L A S N
Sbjct: 346 FAAQIALADDAMKAGESLGIDPAGLAAVLATSSSACIASGVRLRAGSLAGLADSPANLTL 405
Query: 154 GFKNELMVKDLELASGMAL 98
LM + L A G L
Sbjct: 406 TKDATLMAEILGDAPGNGL 424
>UniRef50_O34969 Cluster: Uncharacterized oxidoreductase yfjR; n=1;
Bacillus subtilis|Rep: Uncharacterized oxidoreductase
yfjR - Bacillus subtilis
Length = 261
Score = 74.9 bits (176), Expect = 2e-12
Identities = 64/230 (27%), Positives = 105/230 (45%), Gaps = 2/230 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V+++L + V V G+DG++ + + I STI +++ EKG F
Sbjct: 33 DIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSEKLAAAHAEKGQFFLA 92
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIG-SGQVAKLTNNML 335
APV G A A L + G E + + PLL + + F G+ + AK++ N L
Sbjct: 93 APVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDVGEESKTANAAKISINFL 152
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD- 158
+ A +E M K GLE K L++ +SA S PV T + + ++
Sbjct: 153 LVSMLEALSESFLMMEKYGLEQKQFLEI---ASALFGS-----PVYQNYGTIMAEQKFEP 204
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
GFK L +KD LA A + + +PL +A + +G+G D++
Sbjct: 205 AGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDLDWA 254
>UniRef50_Q0RIL5 Cluster: Putative uncharacterized protein; n=1;
Frankia alni ACN14a|Rep: Putative uncharacterized
protein - Frankia alni (strain ACN14a)
Length = 493
Score = 74.1 bits (174), Expect = 3e-12
Identities = 52/205 (25%), Positives = 98/205 (47%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
V+V+++T+++ DV G++G++A A G ++ ST++ V ++ + E +GF D
Sbjct: 66 VMVAVVTADQA-RDVIGGENGLLAGAHPGLTIVLLSTVELAVVHELAALCAEHDVGFLDC 124
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
V+ G A + +A + GG + E + P+L + HCG +G+G V K+ N++
Sbjct: 125 GVTPGDRAADHGMVAIV-GGDEATVEAARPVLDDWARRVVHCGPLGAGMVTKIARNVVTY 183
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGF 149
+ A E + G+ P L +V++ + + + G P + G
Sbjct: 184 GSWRAVFEASALARAAGVNPARLAEVIDTADPEGHTLLTLLRLRGGDDRLPQAA---GRK 240
Query: 148 KNELMVKDLELASGMALGIRSPIPL 74
LM KDL+ A +A + +PL
Sbjct: 241 IQPLMTKDLDAARDLATALDVDVPL 265
>UniRef50_Q6F842 Cluster: Putative 3-hydroxyisobutyrate
dehydrogenase or 2-hydroxy-3- oxopropionate reductase;
n=2; Acinetobacter|Rep: Putative 3-hydroxyisobutyrate
dehydrogenase or 2-hydroxy-3- oxopropionate reductase -
Acinetobacter sp. (strain ADP1)
Length = 291
Score = 73.7 bits (173), Expect = 4e-12
Identities = 55/227 (24%), Positives = 96/227 (42%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
V++ L ++ V VY + V + +++D S++ N K + A ++ + D+
Sbjct: 63 VILMCLADDQAVNHVY---EQVHHLVRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDS 119
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PVSGG GA+ TL AGG + + + V+ + G G+GQ K+ N +++
Sbjct: 120 PVSGGTSGAEQGTLVIFAGGNESTIQDLGLIYNVLSQRVTRMGDTGTGQATKICNQLIVA 179
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGF 149
AE + + + G++ +L L N A S ++ P P +
Sbjct: 180 ANSALIAEAVALAHRAGVDTTLLAPALANGFADSKPFQILAPRMARQIFEPVQ------W 233
Query: 148 KNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
K + + KDL A +A IP+ A Q GY Q D +
Sbjct: 234 KVQTLAKDLNNAVELATHYALDIPVAHQALHQLHSHQQNGYAQSDLA 280
>UniRef50_Q221W9 Cluster: 2-hydroxy-3-oxopropionate reductase; n=1;
Rhodoferax ferrireducens T118|Rep:
2-hydroxy-3-oxopropionate reductase - Rhodoferax
ferrireducens (strain DSM 15236 / ATCC BAA-621 / T118)
Length = 303
Score = 73.3 bits (172), Expect = 5e-12
Identities = 42/163 (25%), Positives = 75/163 (46%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV++ +T + V +V G G++ K G +++D ST P+ +++ KG F D
Sbjct: 69 DVIIICVTGSPQVEEVVFGDTGILQTLKPGCVVVDCSTSLPDSTRRVAQAIAAKGGQFLD 128
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
A ++G A L + GG E P+ + F+CG + +G KL + ++
Sbjct: 129 AAMTGTPKHADEGKLNLLVGGDPEVLTSVRPVFALFAENIFYCGAVSAGHTTKLLHQFVV 188
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCP 203
AE + K G+ +VL DV+ + A S + + + P
Sbjct: 189 LGNAAILAEAFSCASKTGVNLEVLCDVIASGGANSTAFQRFRP 231
>UniRef50_A0K107 Cluster: 2-hydroxy-3-oxopropionate reductase; n=1;
Arthrobacter sp. FB24|Rep: 2-hydroxy-3-oxopropionate
reductase - Arthrobacter sp. (strain FB24)
Length = 302
Score = 72.5 bits (170), Expect = 9e-12
Identities = 60/231 (25%), Positives = 99/231 (42%), Gaps = 5/231 (2%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSL----LIDSSTIDPNVPKQIFPIALEK-G 527
+VV+++L V + G+DG++A K + L+ T+ P + L G
Sbjct: 69 EVVLTVLPDLPQVAALLPGEDGLLAGWKAAGIEHPVLVIHGTVSPVAVAEFADDCLRNWG 128
Query: 526 LGFTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLT 347
L DAP+SGG +GA+ L+ M GG E ER PL + + H G+ G+G K
Sbjct: 129 LTVVDAPLSGGTIGAEEGRLSIMVGGPAEAVERLTPLFGLYSSTAVHFGKTGAGSTVKAC 188
Query: 346 NNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSR 167
N +++ T A AE M + L+ + + L A S V +
Sbjct: 189 NQIVVAATVNALAEAMALASTAALDLEKVQTTLAGGLANS-------EVLRQKGHRWIDQ 241
Query: 166 NYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
+++GG + +KDL + +A +PL A + + + G G D
Sbjct: 242 DFEGGGSAKNQLKDLNFIAEIAAAHGINLPLAACLQSSFEEMIAAGDGDMD 292
>UniRef50_Q98I20 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Alphaproteobacteria|Rep: 3-hydroxyisobutyrate
dehydrogenase - Rhizobium loti (Mesorhizobium loti)
Length = 305
Score = 71.3 bits (167), Expect = 2e-11
Identities = 57/211 (27%), Positives = 94/211 (44%)
Frame = -3
Query: 682 VSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 503
++ L S K+ V G G++ KG I+ ST + ++ +A +G+ + PV
Sbjct: 63 ITCLPSPKISEAVLAGPGGLLEGLPKGGTWIEMSTNGRDEIMRLAALASAEGVETLECPV 122
Query: 502 SGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGIT 323
+GGV A + + GG +ER ++ M A+ F G IGS V K+ NML I
Sbjct: 123 TGGVHLAAVGKITALVGGDAALYERHRAAIEAMCARSFLMGPIGSAAVIKVITNMLAFIH 182
Query: 322 GMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKN 143
+A E + + + GL+ + SS S+ E + + +YD GF
Sbjct: 183 LVAAGEALMLAKQGGLDLAQSYHAIVASSGNSFVHETESQL-------VLNGSYDIGFTM 235
Query: 142 ELMVKDLELASGMALGIRSPIPLGAVATQLY 50
+L +KDL A GM P+ L + ++
Sbjct: 236 DLALKDLGFALGMGKDFGVPLELASRVNAIF 266
>UniRef50_A6F020 Cluster: Putative uncharacterized protein; n=1;
Marinobacter algicola DG893|Rep: Putative
uncharacterized protein - Marinobacter algicola DG893
Length = 286
Score = 70.9 bits (166), Expect = 3e-11
Identities = 38/119 (31%), Positives = 61/119 (51%)
Frame = -3
Query: 604 GSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDFERS 425
GS ++ +T P + + +KGLGF DAPV G GA+ L + GG + +
Sbjct: 84 GSTVVILATNSPKTMQVLAAECEDKGLGFVDAPVVFGRQGAKEGQLGSLCGGDDKQVAKI 143
Query: 424 LPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVL 248
P+L+ H G +GSGQVAK NNML +A E +++ + G++ + + + L
Sbjct: 144 TPVLESYSKAVHHVGPVGSGQVAKACNNMLHWAACVANFEVLSLAKRYGIDAQQMRETL 202
>UniRef50_P71825 Cluster: Uncharacterized oxidoreductase
Rv0770/MT0794; n=18; Corynebacterineae|Rep:
Uncharacterized oxidoreductase Rv0770/MT0794 -
Mycobacterium tuberculosis
Length = 295
Score = 70.9 bits (166), Expect = 3e-11
Identities = 58/218 (26%), Positives = 88/218 (40%), Gaps = 6/218 (2%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D++ + + V V +G+ HAK G+++ STI + +G+ D
Sbjct: 64 DIISITVFDDAQVSSVITADNGLATHAKPGTIVAIHSTIADTTAVDLAEKLKPQGIHIVD 123
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSGG A LA M G E F+R + H G+ G+G KL NML
Sbjct: 124 APVSGGAAAAAKGELAVMVGADDEAFQRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLT 183
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWST------EVYCPVPGLVPTAPSS 170
++ A AE + GL+ L V+ +S + + P+ P P
Sbjct: 184 FVSYAAAAEAQRLAEACGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLL 243
Query: 169 RNYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQ 56
+ G L KDL LA + + +PL +A Q
Sbjct: 244 EHTRG-----LGEKDLSLALALGEVVSVDLPLAQLALQ 276
>UniRef50_Q9I1R8 Cluster: Probable dehydrogenase; n=7; Pseudomonas
aeruginosa|Rep: Probable dehydrogenase - Pseudomonas
aeruginosa
Length = 291
Score = 70.5 bits (165), Expect = 4e-11
Identities = 56/230 (24%), Positives = 108/230 (46%), Gaps = 1/230 (0%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
+DVV+S+L ++ + V L G + A+ G + + ST+ + + + +GL F
Sbjct: 56 LDVVISMLADDQAIRGVLLDS-GALERARPGLIHLSMSTLSLDCVEALDQAHQRQGLAFV 114
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVA-KLTNNM 338
APV G A+ L + GG +E E+ LL++MG K + G+ G +A K++ N
Sbjct: 115 AAPVFGRTDVAEAGKLNIVVGGPEEAIEQVKALLEIMGQKTWFFGKDPRGAMAVKISGNF 174
Query: 337 LMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD 158
++ + E + + ++G+EP ++++ S+ + VY P R
Sbjct: 175 MIASAIESMGESVALVKRLGVEPGRFMELM---SSTLFDAPVY---RNYGPQIVEQRFTP 228
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
F+ L +KD++LA P+PL ++ + + G G+ D++
Sbjct: 229 ARFRLVLGLKDVDLALSAGKRHNVPLPLASLLHDVLLEAIAHGDGESDWT 278
>UniRef50_A1WEB7 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Verminephrobacter eiseniae EF01-2|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Verminephrobacter eiseniae (strain EF01-2)
Length = 293
Score = 70.1 bits (164), Expect = 5e-11
Identities = 61/231 (26%), Positives = 106/231 (45%), Gaps = 2/231 (0%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
VVV L S L V + + H +G+++I+SST++P G+ DA
Sbjct: 56 VVVLCLPSPASSLSVI---EQIAPHLPQGAVVIESSTVNPEHVHAGQKRLAPFGVDVVDA 112
Query: 508 PVSGGV--MGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
+ GV M A +ATLA GG+ + RS +L + ++Q H G +G+G AK+ NN +
Sbjct: 113 SILAGVEQMAAGSATLAL--GGKPDAIARSQGVLDAIASRQIHFGALGAGAAAKVINNAV 170
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDG 155
+ AE M G+ + L+ +L++ ++ P+ +Y G
Sbjct: 171 AHAVMVVVAEAGAMATAAGVGCEKLIALLSDP-----RMGLHRPLTYRYAQRVVKGDYTG 225
Query: 154 GFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
G + KD LA +A + P+ A +Y I + G+G++D++ +
Sbjct: 226 GMPLDAARKDSTLALQLAQTLGVPLFAIQGAHSVYDIAAAAGHGRQDYAVI 276
>UniRef50_A0R1N5 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Mycobacterium|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Mycobacterium smegmatis
(strain ATCC 700084 / mc(2)155)
Length = 263
Score = 70.1 bits (164), Expect = 5e-11
Identities = 45/154 (29%), Positives = 71/154 (46%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
V+V + T +V L D ++ G++L+ +T P + I A ++G+ DA
Sbjct: 60 VIVCVFTDEQVRT---LCTDTLLDAMAPGAVLVLHTTGSPRTAEDIAARAADRGVAVVDA 116
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PVSGG ++ AGG + ER P L H G +GSGQ KL NN +
Sbjct: 117 PVSGGPHDIAAGSVTVFAGGDADVVERVRPALVAYAEPLLHVGPLGSGQRVKLVNNTMFA 176
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARS 227
AE + + ++G++ +L L + SA S
Sbjct: 177 AQIGVVAEGVRLARELGVDEPTVLSALTHGSAAS 210
>UniRef50_A4S5A4 Cluster: Predicted protein; n=2; Ostreococcus|Rep:
Predicted protein - Ostreococcus lucimarinus CCE9901
Length = 319
Score = 69.7 bits (163), Expect = 6e-11
Identities = 57/198 (28%), Positives = 89/198 (44%), Gaps = 1/198 (0%)
Frame = -3
Query: 592 IDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLL 413
+D ST+D + I L + + F APVSGG A L F+ GG +E +
Sbjct: 118 VDCSTVDGACGEATREI-LGENVRFLAAPVSGGWRDAAKGELLFLGGGDARAYEDGARFM 176
Query: 412 KVMGAKQFHCGQIGSGQV-AKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSS 236
VMGAK++ G + AKL ++MG A E + + GL+ +L++L++S+
Sbjct: 177 DVMGAKRWLVGDSPTHAARAKLMLQIMMGNVVGALGEMHALSERAGLDSNAILEMLSHSA 236
Query: 235 ARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQ 56
S P+ + RN+ F+ L KDL LA +A + P+ A
Sbjct: 237 MGS-------PLTTAKGKLMADRNFAPNFQVYLQQKDLRLALNLADELDFAAPITAATNA 289
Query: 55 LYRIVQSRGYGQKDFSFV 2
Y +S G+ DF+ V
Sbjct: 290 QYLKAKSLGHANSDFAAV 307
>UniRef50_A0YMN9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3;
Cyanobacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Lyngbya sp. PCC 8106
Length = 371
Score = 69.3 bits (162), Expect = 8e-11
Identities = 55/205 (26%), Positives = 92/205 (44%), Gaps = 8/205 (3%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
+ ++ T + + V G+ + + GS+ ID +T P ++ G+ D
Sbjct: 76 IFTALPTPSDTIKAVLEGEQNLSQGLRSGSIYIDITTNSPETIHRLHQAISPLGVEMLDV 135
Query: 508 PV---SGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNM 338
P S G LA +A G + FER PLL++M + +CG+IGSG KL +N
Sbjct: 136 PFNDCSEGATSEGGMGLAVLASGSRATFERVEPLLQLMADQVLYCGEIGSGTRCKLIHNA 195
Query: 337 LMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD 158
+ + A +E + +G+ G+ + + D L S +++ GL P SR D
Sbjct: 196 VNAVAVQAVSEGITLGLAQGISLETIWDTLRFGSFGQNPGDIH----GL-PYYWFSRRCD 250
Query: 157 -----GGFKNELMVKDLELASGMAL 98
F +L+ KDL +A MA+
Sbjct: 251 HLSKPPAFTVKLLHKDLRIALDMAI 275
>UniRef50_Q74D68 Cluster: 3-hydroxyisobutyrate dehydrogenase family
protein; n=7; Desulfuromonadales|Rep:
3-hydroxyisobutyrate dehydrogenase family protein -
Geobacter sulfurreducens
Length = 288
Score = 68.5 bits (160), Expect = 1e-10
Identities = 60/230 (26%), Positives = 92/230 (40%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V+ I + + G DG+ A G++L+D T ++ A + + F D
Sbjct: 60 DIVIHIRPEKERLRPDIYGPDGIFAGIDPGTILVDMGTHSLTSTMEMADEAAKHRVMFLD 119
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APV G A N L +AGG R L G H G IG K N++
Sbjct: 120 APVWGTKEHAANGLLTILAGGDPSLVGRCRELFSFFGLNIIHVGSIGDATRMKFVVNLVQ 179
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
A AE + G K+G +L+VL++ S ++ + +RN
Sbjct: 180 AELMQALAESIVFGEKLGFTADRILEVLDSGGVAS---PLFHSKGRSIARGDFTRNLALK 236
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
+ +E + LE A + L +P VA Y G G++DFS V
Sbjct: 237 YVHEQLELVLEKAEKLGL----ELPAAKVACATYEQGVKDGRGEEDFSSV 282
>UniRef50_Q01PV6 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Solibacter usitatus Ellin6076|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Solibacter usitatus (strain Ellin6076)
Length = 267
Score = 68.5 bits (160), Expect = 1e-10
Identities = 52/203 (25%), Positives = 86/203 (42%), Gaps = 2/203 (0%)
Frame = -3
Query: 604 GSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDFERS 425
G ++D +T +P + + G+ + DA V G ++ MAGGR+E F+ +
Sbjct: 67 GITMVDCTTGEPESMAAMGEKLAKSGVDYLDATVLGSSKVVRSGAAVVMAGGRRESFDAA 126
Query: 424 LPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVLN 245
PL + ++ F+ G G+G KL N+ +G+ AE + + P V L+VL
Sbjct: 127 SPLFRTFASRAFYLGPFGAGARMKLVVNLALGLHRAVLAETLAFAHACEVSPTVALEVLK 186
Query: 244 NSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELM--VKDLELASGMALGIRSPIPLG 71
+A S E ++D + L +KD+ L A + PL
Sbjct: 187 AGAAYSRVME---------DKGEKMLHHDFTVEARLSQHLKDVRLILDAAAAKHAKTPLS 237
Query: 70 AVATQLYRIVQSRGYGQKDFSFV 2
V QL + + GYG D S +
Sbjct: 238 QVHRQLLEGLVTAGYGDADNSAI 260
>UniRef50_A0VSV4 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=1; Dinoroseobacter shibae DFL
12|Rep: 6-phosphogluconate dehydrogenase, NAD-binding
precursor - Dinoroseobacter shibae DFL 12
Length = 289
Score = 68.1 bits (159), Expect = 2e-10
Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 5/206 (2%)
Frame = -3
Query: 631 DGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAG 452
D ++ H + G + ID++T P + G F+DAPV+GG AQ+ L + G
Sbjct: 79 DTLLPHTRPGQIWIDTTTSRPETSATLAHRLDAAGAVFSDAPVTGGPKQAQDGALTSLVG 138
Query: 451 GRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLE 272
F+ L+ G G+G AKL NN++ T + ++ ++G++
Sbjct: 139 CAAAQFDTIASLVGTYSTAIRRFGDAGTGHAAKLLNNLVTQGTMVLLSDAFQAAGRLGVD 198
Query: 271 PKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG-FKNELMVKDLELASGM--- 104
P+ L +V+ +ARS + + P P L +Y G F KDL A +
Sbjct: 199 PRALYEVMMTGAARSGTLQKAVP-PAL------DGDYTGARFSISNAAKDLGYAEALLAD 251
Query: 103 ALGIRSPIPLGAVATQLYRI-VQSRG 29
AL R+ + GA+A +L + Q RG
Sbjct: 252 ALPGRADV-AGALAARLGALAAQGRG 276
>UniRef50_UPI0000EBE4FC Cluster: PREDICTED: hypothetical protein;
n=1; Bos taurus|Rep: PREDICTED: hypothetical protein -
Bos taurus
Length = 351
Score = 67.7 bits (158), Expect = 3e-10
Identities = 46/183 (25%), Positives = 78/183 (42%)
Frame = -3
Query: 550 FPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIG 371
F + + +G F +APVSG + + L +A G + +E + MG F G++G
Sbjct: 170 FQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVG 229
Query: 370 SGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGL 191
+ L NM+ G AE + + G + LLD+LN S + C +
Sbjct: 230 NAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKC--QNI 287
Query: 190 VPTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDF 11
+ N+ F + + KDL LA + + P P+ A A ++Y+ ++ D
Sbjct: 288 L-----QGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDM 342
Query: 10 SFV 2
S V
Sbjct: 343 SAV 345
>UniRef50_Q21AH6 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Bacteria|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Rhodopseudomonas palustris
(strain BisB18)
Length = 292
Score = 67.3 bits (157), Expect = 3e-10
Identities = 52/204 (25%), Positives = 91/204 (44%), Gaps = 2/204 (0%)
Frame = -3
Query: 619 AHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMG-AQNATLAFMAGGRK 443
A +G++ +D STIDP +++ + + G A G A+ + GG +
Sbjct: 84 ADLAEGAIAVDLSTIDPATSRRVSDMIAKGGRARFVACTMGKTPAMAEKGEIPLFVGGDQ 143
Query: 442 EDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMAT-AECMNMGIKMGLEPK 266
E P+ K M + F G + + KL +N L+G+T +A AE + K G++P+
Sbjct: 144 VSLEALAPVFKHMSSVVFDMGSVEGATMFKLISN-LVGMTNLAILAEGYLLARKAGIDPE 202
Query: 265 VLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRS 86
V L + WST+ + ++ ++R F +L KDL L+ A
Sbjct: 203 VFSSALKTTGG--WSTQADIRLGWMINDDFTTR-----FAVDLAAKDLRLSVNAAATWGI 255
Query: 85 PIPLGAVATQLYRIVQSRGYGQKD 14
P P+ A ++ + ++ G G KD
Sbjct: 256 PTPVAAAGLSVFSLARAAGLGSKD 279
>UniRef50_Q1GM24 Cluster: 6-phosphogluconate dehydrogenase
NAD-binding; n=3; Rhodobacteraceae|Rep:
6-phosphogluconate dehydrogenase NAD-binding -
Silicibacter sp. (strain TM1040)
Length = 292
Score = 67.3 bits (157), Expect = 3e-10
Identities = 43/163 (26%), Positives = 69/163 (42%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV+ +T + V + G GV ++ ++++D ST P ++ I G + D
Sbjct: 60 DVVILCVTGSPQVEAIVAGDQGVATALRQNAVIVDCSTALPESTLRMAEIVRAAGGDYLD 119
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
AP++ A TL + GG + ER P+L H G + G KL +N +
Sbjct: 120 APMTRTARHAHEGTLNLLVGGATDTLERVRPVLSTFTEDVAHVGPLSHGHRLKLLHNYVS 179
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCP 203
AE G++P V +DVL + S + E P
Sbjct: 180 VGFMTLLAEAAAQSADAGVDPAVFVDVLASGGGASVALERLAP 222
>UniRef50_A1UJF3 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=4; Actinomycetales|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Mycobacterium sp. (strain KMS)
Length = 272
Score = 67.3 bits (157), Expect = 3e-10
Identities = 44/154 (28%), Positives = 70/154 (45%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
VVV + T ++V G G++A G+ L+ +T P+ + + + G+ DA
Sbjct: 61 VVVCVFTDDQVRAVCLDG--GLLAAMAPGATLVIHTTGSPDTARLLAARGRDHGVDVVDA 118
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PVSGG + GG + ER+ P+L G H G +G+GQ KL NN +
Sbjct: 119 PVSGGPHDIAAGAVTLFVGGSEAAVERARPVLAAYGDPILHVGPLGAGQSVKLVNNTVFA 178
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARS 227
E + +G +G+ LL L + S+ S
Sbjct: 179 AQIGLLREAVRLGGALGVAEPDLLTALTHGSSSS 212
>UniRef50_Q98K09 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=7;
Alphaproteobacteria|Rep: 3-hydroxyisobutyrate
dehydrogenase - Rhizobium loti (Mesorhizobium loti)
Length = 312
Score = 66.9 bits (156), Expect = 4e-10
Identities = 42/150 (28%), Positives = 66/150 (44%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D+V +T ++ V + G G+ KKGS+++D ST DP + G+ + D
Sbjct: 66 DIVFICVTGSREVEAIIRGPGGLKEGLKKGSVVVDCSTSDPVSTVALAAELKALGIDYVD 125
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
AP+S A TL M G F R P+++ + H G G G KL NN +
Sbjct: 126 APLSRTPKEAWEGTLDAMVGAPDAVFARVKPVIETWAGRIVHIGDTGDGHRMKLLNNFIS 185
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNN 242
+E + + K+G+ P V+ N
Sbjct: 186 LGYAAIYSEALALAEKVGISPPRFDSVIRN 215
>UniRef50_A5CN67 Cluster: Putative beta-hydroxyacid dehydrogenase;
n=1; Clavibacter michiganensis subsp. michiganensis
NCPPB 382|Rep: Putative beta-hydroxyacid dehydrogenase -
Clavibacter michiganensis subsp. michiganensis (strain
NCPPB 382)
Length = 291
Score = 66.9 bits (156), Expect = 4e-10
Identities = 43/154 (27%), Positives = 74/154 (48%), Gaps = 1/154 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVVV +L VL+V V + G++++ SST+ ++I +A E + F D
Sbjct: 56 DVVVVMLFDADAVLEVLAE---VAPALRPGAVVLQSSTVGVEGTRRIAALAAEHAVRFVD 112
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCG-QIGSGQVAKLTNNML 335
APV G A+ L + G ++D + P+L+ G++ G G G KL N
Sbjct: 113 APVLGTRGPAEQGLLVHLVSGSEDDLAVARPVLEATGSRTVVAGSDAGPGSALKLACNAW 172
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSA 233
+ AT + + + +G+EP++ LD + +A
Sbjct: 173 IASITAATGQSLGLARLLGVEPRLFLDAIAGGAA 206
>UniRef50_A6RMW8 Cluster: Putative uncharacterized protein; n=2;
Sclerotiniaceae|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 446
Score = 66.5 bits (155), Expect = 6e-10
Identities = 60/233 (25%), Positives = 103/233 (44%), Gaps = 6/233 (2%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDP-NVP--KQIFPIALE-KGLG 521
+V+ + T+ + + ++ G + + + +I SST P +VP +++ K +
Sbjct: 65 IVIMVATAAQTLAVLFDDVTGAIHELQPNATIILSSTAFPEHVPEVRELLDNKYNRKDVE 124
Query: 520 FTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHC--GQIGSGQVAKLT 347
DAPVSGG A TL +A G ++ + + P+L M A H G +G+G K+
Sbjct: 125 LVDAPVSGGTSRAALGTLVILASGPEKSLDAAKPVLDAM-ADPLHMIPGGLGAGTKVKMV 183
Query: 346 NNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSR 167
+ L GI + +E M +GL K D L SS SW + VP +
Sbjct: 184 HQALAGIHMIMASEAMGFAAFLGLNTKQAFDYLVKSSGESWM------LGNRVPHMLEND 237
Query: 166 NYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
+ N + VKD+ + + ++ P+ L + A Q+ G+G D S
Sbjct: 238 LHPYSALN-IFVKDMGIVTADGRRVKCPLFLCSAAEQVLASGVRSGFGLDDDS 289
>UniRef50_Q1NHF5 Cluster: Putative oxidoreductase; n=1; Sphingomonas
sp. SKA58|Rep: Putative oxidoreductase - Sphingomonas
sp. SKA58
Length = 283
Score = 65.7 bits (153), Expect = 1e-09
Identities = 55/209 (26%), Positives = 93/209 (44%), Gaps = 3/209 (1%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DVV+ + + K +DV G DGV++ A+ G +++ +T+ I + G+ D
Sbjct: 59 DVVIIAVVNAKQTIDVLSGPDGVLSRARPGMIVVLVATVSIEDLDAIRALTDAAGVELVD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
V+GG ++ L + GG E + P+L H G G+G AK+ N+++
Sbjct: 119 CGVTGGPKSREHG-LVCLVGGTDETIAKVRPVLDGFAKLVAHMGGPGAGMAAKIARNVIV 177
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
A E + G++ + L +V++ S S V P+ V PSS +
Sbjct: 178 FGCLRAGHEASVLCRNAGVDIRQLAEVIDAS-----SDSVGGPLMLAVRDDPSSSEQEAA 232
Query: 151 ---FKNELMVKDLELASGMALGIRSPIPL 74
+ LMVKDL+ A +A +PL
Sbjct: 233 VREYTRSLMVKDLDAAIDLARSYGIALPL 261
>UniRef50_Q39KK8 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=34; Bacteria|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Burkholderia sp. (strain
383) (Burkholderia cepacia (strain ATCC 17760/ NCIB 9086
/ R18194))
Length = 289
Score = 65.3 bits (152), Expect = 1e-09
Identities = 56/230 (24%), Positives = 100/230 (43%), Gaps = 2/230 (0%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D V S+L + ++ D ++A A +G + ++ +T+ + + + +G+ +
Sbjct: 57 DAVFSMLADDAAARAIF--DDALLAQAPRGLIHVNMATVSVALAESLAHAHASRGIHYVA 114
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGS-GQVAKLTNNML 335
APV G A A L MAGG E +R PL +G K + G + VAK+ N
Sbjct: 115 APVMGRPDVAAAARLTIMAGGPAEAIDRVQPLFDAIGQKTWRFGSLPQHANVAKIAANFT 174
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYD- 158
+ E + G+ + LDV+ S + VY ++ + R+Y+
Sbjct: 175 LASAIETLGEASALLGAHGVAMRDFLDVITGS---VFPGPVYEGYGSMI----AERHYEP 227
Query: 157 GGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
FK L +KD+ LA + P+P+ +V + G G++DF+
Sbjct: 228 ARFKARLGLKDVRLALEAGDAVSVPLPVASVVRDNLLDALAHGGGEQDFA 277
>UniRef50_A3Q3U7 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Mycobacterium|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Mycobacterium sp. (strain
JLS)
Length = 279
Score = 65.3 bits (152), Expect = 1e-09
Identities = 45/155 (29%), Positives = 67/155 (43%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
DV++S L S+ + + LG +G +A+AK ++ + S T G D
Sbjct: 60 DVLISCLFSDAQLRETGLGPNGFIANAKPAAVFV-SHTTGTVATLTALRDHSSSGPVVLD 118
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
APVSG TL + GG + P+L G +GS KL NN+L
Sbjct: 119 APVSGTADDIAAGTLTVLLGGPADAVAAVTPVLAAYADPLVPTGTLGSALALKLINNLLF 178
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARS 227
A +G ++G++P+VLL L SA S
Sbjct: 179 AANAQLLAAATELGTQLGVDPEVLLSTLQVCSAGS 213
>UniRef50_Q1GF31 Cluster: 6-phosphogluconate dehydrogenase
NAD-binding; n=17; Proteobacteria|Rep:
6-phosphogluconate dehydrogenase NAD-binding -
Silicibacter sp. (strain TM1040)
Length = 325
Score = 64.9 bits (151), Expect = 2e-09
Identities = 49/195 (25%), Positives = 85/195 (43%)
Frame = -3
Query: 592 IDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLL 413
++ ST D K++ + E+G + PVSGG A ++ AG + FER LP L
Sbjct: 88 MEMSTTDAAEVKRLAALVSERGGSAMECPVSGGCHRADTGNISIFAGCDRATFERMLPTL 147
Query: 412 KVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSA 233
+G + H G IGS + K+ N L + E + G++ + + SS
Sbjct: 148 TTLGRRVLHTGDIGSASILKVMTNYLATANLLTCCEALVTMKAAGIDLNTTYEAMKISSG 207
Query: 232 RSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQL 53
S+ E V SR D F +L+ KD+ L +A P+ + + ++
Sbjct: 208 TSFVHETESQV-----ILNGSR--DISFTMDLVKKDISLFQTIADAHGVPLEISPLLVEI 260
Query: 52 YRIVQSRGYGQKDFS 8
+ +R +G+++ S
Sbjct: 261 FTDGIAR-FGERELS 274
>UniRef50_Q5LQS2 Cluster: 3-hydroxyisobutyrate dehydrogenase family
protein; n=2; Alphaproteobacteria|Rep:
3-hydroxyisobutyrate dehydrogenase family protein -
Silicibacter pomeroyi
Length = 303
Score = 64.1 bits (149), Expect = 3e-09
Identities = 39/151 (25%), Positives = 71/151 (47%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D++ L ++K V V G +G++A A+ G ++ID++T DP + +G+ D
Sbjct: 62 DIIHICLGNSKQVEAVIRGPEGILAAARPGLIVIDTTTADPVSTLALAAEMAAQGVHMVD 121
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
AP+ A++ TL M G + + P++ G +G+G KL N L
Sbjct: 122 APLGRTPKEAEDGTLDAMVGCDEALMKTITPVIDCWAGTITRIGPVGAGHKMKLLMNFLG 181
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNS 239
G +E + +G ++G+ P +V+ S
Sbjct: 182 GAYAALYSEAVVLGARVGISPHTFREVIGPS 212
>UniRef50_Q120Q9 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=7; Burkholderiales|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 297
Score = 63.7 bits (148), Expect = 4e-09
Identities = 42/149 (28%), Positives = 68/149 (45%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VD+++ +T V DV K G++ K G+++ID ST P+ +I + G F
Sbjct: 59 VDIIILCVTGTPEVEDVLYRKGGLLEGIKPGTIVIDCSTAIPSSTIRIAESVEKAGGRFL 118
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNML 335
DAP++ A L + GG FE P+L+ G +GSG KL +N +
Sbjct: 119 DAPMTRTPKEAAEGRLNLIVGGDPALFESCKPVLECYAENIVLAGPVGSGHRLKLLHNFV 178
Query: 334 MGITGMATAECMNMGIKMGLEPKVLLDVL 248
AE G++P+V +++L
Sbjct: 179 SLGFSAVLAEAAACADCSGIDPQVFVEIL 207
>UniRef50_A4FKN9 Cluster: 2-hydroxy-3-oxopropionate reductase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
2-hydroxy-3-oxopropionate reductase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 297
Score = 63.7 bits (148), Expect = 4e-09
Identities = 56/227 (24%), Positives = 100/227 (44%)
Frame = -3
Query: 688 VVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 509
VVVS+ + +V V DG++A + +++D+ST P + + +G DA
Sbjct: 68 VVVSLPSGPQVRAAVV---DGLLADGGE-FVVVDTSTCAPADARSLADDLHARGCAVVDA 123
Query: 508 PVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMG 329
PVSGG A+ +L+ M GG + D + +++ + CG G+GQ+AK N +++
Sbjct: 124 PVSGGPTAARAGSLSVMVGGTEADVAAADEVIRAFAGRVVVCGGPGAGQIAKACNQLVVT 183
Query: 328 ITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGF 149
AE + +G +P + + L A S E++ R++ G
Sbjct: 184 AGIAVVAEALVTASALGADPAAVREALLGGYAASRILELH-------GDRMLRRDFTLGA 236
Query: 148 KNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
+KD+ + + G+ A A + +V+S G G D S
Sbjct: 237 AARTQLKDIGIIRELTEGVVDNQVFEAAARAMEELVESGG-GDLDHS 282
>UniRef50_A3H6C3 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Caldivirga maquilingensis IC-167|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Caldivirga maquilingensis IC-167
Length = 284
Score = 63.7 bits (148), Expect = 4e-09
Identities = 53/222 (23%), Positives = 101/222 (45%), Gaps = 5/222 (2%)
Frame = -3
Query: 658 VVLDVYLGKDGV-----VAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGG 494
V++ V G++ + +A+A KG +++D++T+ + + I EK L + + G
Sbjct: 60 VIIAVPTGRESISVISNIANAAKG-IILDTTTMSLSELSNVLKIIEEKRLRYLSVRLEKG 118
Query: 493 VMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMA 314
A+ L GG + F+ + +L +G + G KL +N+++ +
Sbjct: 119 PREAERGELVLYVGGDEGLFKEANSILSQIGTP-IYVGNHEQATALKLISNVILTANTVV 177
Query: 313 TAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGGFKNELM 134
AE + K+G++P ++ L S S S ++ +P ++ NY F L
Sbjct: 178 LAEVSVLIRKLGMDPDTVVKAL--SMGGSDSAQLRTRLPWML-----KGNYGESFSLRLA 230
Query: 133 VKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFS 8
++ A A I +P+ + +L RI ++ GYG KDFS
Sbjct: 231 RDVIDKALEYAQSIGIQLPMTTLIDELLRIAETTGYGSKDFS 272
>UniRef50_A3H9B3 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Caldivirga maquilingensis IC-167|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Caldivirga maquilingensis IC-167
Length = 293
Score = 62.9 bits (146), Expect = 7e-09
Identities = 55/231 (23%), Positives = 104/231 (45%), Gaps = 4/231 (1%)
Frame = -3
Query: 694 VDVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 515
VD+V++ + ++ VLDVYLG +G+++ AK G + +++ST D ++ + +GF
Sbjct: 57 VDIVLTNVPRSEDVLDVYLGGNGILSGAKPGLIAVETSTTDIKTKLRVAEECRRRNVGFI 116
Query: 514 DAPVSGGVMGAQNATLAFMAGGRKEDF--ERSLPLLK-VMGAKQFHCGQIGSGQVAKLTN 344
A + V A+ GG +E F +R + + + + ++ I + KL
Sbjct: 117 VAMLGKTVPQAERGETPLFVGGPEEVFRDKRVQEVFQAISSGRIYYMRTIEAAVAFKLIT 176
Query: 343 NMLMGITGMAT-AECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSR 167
N MG + T E + K G+ + L+ +++A ++ +
Sbjct: 177 NS-MGFAQLLTFLEGLLFIQKFGISIEEFLEAARDTAAYNYWFDAR-------REKILKE 228
Query: 166 NYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
+Y F + ++KDL A + P+P A+A Q Y + GYG +D
Sbjct: 229 DYSAYFSIDYIIKDLMYTLEEAKELGCPLPATALALQYYVAAKGMGYGGED 279
>UniRef50_Q6RXW5 Cluster: Succinic semialdehyde dehydrogenase; n=2;
Rhodococcus|Rep: Succinic semialdehyde dehydrogenase -
Rhodococcus sp. TK6
Length = 262
Score = 62.5 bits (145), Expect = 1e-08
Identities = 41/137 (29%), Positives = 68/137 (49%), Gaps = 1/137 (0%)
Frame = -3
Query: 631 DGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAQNATLA-FMA 455
+ + AH + + +T+ P ++I P A G +APVSGG GA++ ++ F+A
Sbjct: 76 EALAAHTAQPLTVFVHTTLAPADARKILPSA-PAGWRVFEAPVSGGPQGARHGSMTVFLA 134
Query: 454 GGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLMGITGMATAECMNMGIKMGL 275
G D E +L L+ + + F G + KL NN L ATA +N+ + G+
Sbjct: 135 GPAPTDAENAL--LEDISGRVFQMESYGQPALVKLLNNALATYNLAATARMLNLAAEHGV 192
Query: 274 EPKVLLDVLNNSSARSW 224
K L +V+ S+ +SW
Sbjct: 193 PAKDLFEVIGVSTGQSW 209
>UniRef50_Q13VQ8 Cluster: Putative dehydrogenase/oxidoreductase
protein; n=2; Burkholderiales|Rep: Putative
dehydrogenase/oxidoreductase protein - Burkholderia
xenovorans (strain LB400)
Length = 300
Score = 62.5 bits (145), Expect = 1e-08
Identities = 54/230 (23%), Positives = 88/230 (38%)
Frame = -3
Query: 691 DVVVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 512
D + L + V G G++ K G +++ T + G +
Sbjct: 64 DFIFLCLPNESASNAVLEGVGGILPLLKDGKTVVEVGTYRKSFKLMQAEKIQATGANILE 123
Query: 511 APVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQFHCGQIGSGQVAKLTNNMLM 332
A +SG F GG +E+ PLL+ + +F G G+ KL N L+
Sbjct: 124 AELSGSPSLVLARKACFYVGGTDSVYEKCEPLLQAITDNRFFLGAFGTAVSMKLIANYLV 183
Query: 331 GITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSRNYDGG 152
+ +A AE MN+G + G P +L VL+ + S V P+ P+ G
Sbjct: 184 TVNTLAAAEAMNLGTRAGFSPDLLARVLSVGAGASAMMSVRAPIMASRKFEPA----PGS 239
Query: 151 FKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKDFSFV 2
F + K L+L + + PL A A +R +G +D + V
Sbjct: 240 FIT--LEKYLDLGQELVSELGCSAPLYAAAVPYFRRAIEQGLQNEDIAAV 287
>UniRef50_A6R0U9 Cluster: Predicted protein; n=1; Ajellomyces
capsulatus NAm1|Rep: Predicted protein - Ajellomyces
capsulatus NAm1
Length = 444
Score = 62.1 bits (144), Expect = 1e-08
Identities = 59/231 (25%), Positives = 96/231 (41%), Gaps = 7/231 (3%)
Frame = -3
Query: 685 VVSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDP----NVPKQIFPIALEKGLGF 518
V + T+ + + ++ ++G+ G+ LI ST+ + Q+ I E + F
Sbjct: 66 VCMVATAAQAQVAIFDHENGIAKGLPSGATLILCSTVSAVSAQSYRDQLVSIGRED-VYF 124
Query: 517 TDAPVSGGVMGAQNATLAFMAGGRKEDFERSLPLLKVMGAKQ---FHCGQIGSGQVAKLT 347
DAPVSGG A TL MAGG E LL M F G +G+G K+
Sbjct: 125 IDAPVSGGARKAGEGTLTIMAGGSDAALEEGKFLLTEMADTNKLYFVPGGVGAGSNMKMI 184
Query: 346 NNMLMGITGMATAECMNMGIKMGLEPKVLLDVLNNSSARSWSTEVYCPVPGLVPTAPSSR 167
+ + I +A +E M +GL + + +S A S+ E C
Sbjct: 185 HQVFAAIHILAASEVMGFAAHLGLNAEEAGKAVTSSLAWSFMHENRC------ERMLRED 238
Query: 166 NYDGGFKNELMVKDLELASGMALGIRSPIPLGAVATQLYRIVQSRGYGQKD 14
Y G +++KD+ + + A P PL ++A Q++ G+G D
Sbjct: 239 YYPGASAITIILKDVGIVTAAARLHNFPTPLCSIAEQIFITALPLGFGGDD 289
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 824,974,359
Number of Sequences: 1657284
Number of extensions: 18987727
Number of successful extensions: 60282
Number of sequences better than 10.0: 319
Number of HSP's better than 10.0 without gapping: 56517
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 59990
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 54958682807
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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