Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= maV30299
(722 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP], mitoch... 329 5e-89
UniRef50_Q8LPJ5 Cluster: Isocitrate dehydrogenase-like protein; ... 312 6e-84
UniRef50_Q9SRZ6 Cluster: F12P19.10 protein; n=26; cellular organ... 293 2e-78
UniRef50_A2WMU2 Cluster: Putative uncharacterized protein; n=5; ... 270 2e-71
UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial... 264 2e-69
UniRef50_UPI0000F1EC8D Cluster: PREDICTED: similar to Isocitrate... 249 5e-65
UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1; ... 246 6e-64
UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridi... 244 1e-63
UniRef50_A2XVE4 Cluster: Putative uncharacterized protein; n=2; ... 87 1e-28
UniRef50_Q00WM7 Cluster: COG0538: Isocitrate dehydrogenases; n=3... 109 9e-23
UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5; Gammapro... 99 1e-19
UniRef50_Q2K7T8 Cluster: NADP-dependent isocitrate dehydrogenase... 94 4e-18
UniRef50_Q5DBI8 Cluster: SJCHGC09598 protein; n=1; Schistosoma j... 84 3e-15
UniRef50_A3K670 Cluster: NADP-dependent isocitrate dehydrogenase... 77 4e-13
UniRef50_A4VDP7 Cluster: Putative uncharacterized protein; n=1; ... 69 2e-10
UniRef50_Q4VCC2 Cluster: Isocitrate dehydrogenase; n=4; Eukaryot... 62 2e-08
UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5; B... 52 1e-05
UniRef50_Q40658 Cluster: Isocitrate dehydrogenase; n=1; Oryza sa... 44 0.004
UniRef50_Q5E609 Cluster: Putative uncharacterized protein; n=1; ... 35 1.8
UniRef50_Q0SU98 Cluster: DNA/RNA helicase, SNF2; n=2; Clostridiu... 35 2.3
UniRef50_A4WT53 Cluster: Sensor protein; n=3; Rhodobacter sphaer... 35 2.3
UniRef50_Q46FZ3 Cluster: Putative uncharacterized protein; n=1; ... 34 3.1
UniRef50_UPI0000498AD5 Cluster: hypothetical membrane-spanning p... 33 7.1
UniRef50_Q142V0 Cluster: Putative uncharacterized protein; n=1; ... 33 7.1
UniRef50_Q0WVR7 Cluster: TRNA synthase-like protein; n=7; Eukary... 33 9.4
UniRef50_A5BB87 Cluster: Putative uncharacterized protein; n=1; ... 33 9.4
UniRef50_A2ERX8 Cluster: CAP-Gly domain containing protein; n=1;... 33 9.4
>UniRef50_P48735 Cluster: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH); n=493;
cellular organisms|Rep: Isocitrate dehydrogenase [NADP],
mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Homo
sapiens (Human)
Length = 452
Score = 329 bits (808), Expect = 5e-89
Identities = 154/225 (68%), Positives = 180/225 (80%), Gaps = 2/225 (0%)
Frame = +2
Query: 53 YNMSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTI 229
Y +IK A PVV++ GDEMTRIIW IKEKLILP +DI+L +DLG+ NRD+TDDQVTI
Sbjct: 39 YADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTI 98
Query: 230 DCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIP 409
D A A +KY+V +KCATITPDE RVEEFKLKKMWKSPNGTIRNILGGTVFRE IICKNIP
Sbjct: 99 DSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIP 158
Query: 410 RLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKH-VVHEYKGAGVA 586
RLV GW KPI IGRHAH DQYKATDFV AGT +++F P+ G +K V+ + GV
Sbjct: 159 RLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVG 218
Query: 587 LAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFK 721
+ M+NTD SI FAHS F++A+ +K+PLY+STKNTILK YDGRFK
Sbjct: 219 MGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFK 263
>UniRef50_Q8LPJ5 Cluster: Isocitrate dehydrogenase-like protein;
n=6; core eudicotyledons|Rep: Isocitrate
dehydrogenase-like protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 485
Score = 312 bits (766), Expect = 6e-84
Identities = 144/215 (66%), Positives = 175/215 (81%), Gaps = 1/215 (0%)
Frame = +2
Query: 80 PVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYN 259
P+V++ GDEMTR+IW +IKEKLILP+LD+++ +DLG+ NRD TDD+VT++ AEA KYN
Sbjct: 81 PIVEMDGDEMTRVIWSMIKEKLILPYLDLDIKYFDLGILNRDATDDKVTVESAEAALKYN 140
Query: 260 VGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKPI 439
V IKCATITPDE RV+EF LK MW+SPNGTIRNIL GTVFRE I+C NIPRLV GW+KPI
Sbjct: 141 VAIKCATITPDEGRVKEFGLKSMWRSPNGTIRNILDGTVFREPIMCSNIPRLVPGWEKPI 200
Query: 440 IIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEA-IKHVVHEYKGAGVALAMFNTDASI 616
IGRHA DQY+ATD V+ G G L+++F PE G A ++ V+++KG GVALAM+N D SI
Sbjct: 201 CIGRHAFGDQYRATDTVIKGPGKLKMVFVPEDGNAPVELDVYDFKGPGVALAMYNVDESI 260
Query: 617 IDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFK 721
FA SS AL +K+PLYLSTKNTILKKYDGRFK
Sbjct: 261 RAFAESSMAMALTKKWPLYLSTKNTILKKYDGRFK 295
>UniRef50_Q9SRZ6 Cluster: F12P19.10 protein; n=26; cellular
organisms|Rep: F12P19.10 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 410
Score = 293 bits (720), Expect = 2e-78
Identities = 139/220 (63%), Positives = 170/220 (77%), Gaps = 1/220 (0%)
Frame = +2
Query: 65 KIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAE 241
KIK A P+V++ GDEMTR+IW IK+KLI PF+++++ +DLG+ +RD TDD+VTI+ AE
Sbjct: 5 KIKVANPIVEMDGDEMTRVIWKSIKDKLITPFVELDIKYFDLGLPHRDATDDKVTIESAE 64
Query: 242 AIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVT 421
A KKYNV IKCATITPDE RV EF LK+MW+SPNGTIRNIL GTVFRE IICKN+P+LV
Sbjct: 65 ATKKYNVAIKCATITPDEGRVTEFGLKQMWRSPNGTIRNILNGTVFREPIICKNVPKLVP 124
Query: 422 GWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAMFN 601
GW KPI IGRHA DQY+ATD V+ G G L + F+ + G+ V GVA+AM+N
Sbjct: 125 GWTKPICIGRHAFGDQYRATDAVIKGPGKLTMTFEGKDGKTETEVFTFTGEGGVAMAMYN 184
Query: 602 TDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFK 721
TD SI FA +S A ++K+PLYLSTKNTILKKYDGRFK
Sbjct: 185 TDESIRAFADASMNTAYEKKWPLYLSTKNTILKKYDGRFK 224
>UniRef50_A2WMU2 Cluster: Putative uncharacterized protein; n=5;
Eukaryota|Rep: Putative uncharacterized protein - Oryza
sativa subsp. indica (Rice)
Length = 475
Score = 270 bits (662), Expect = 2e-71
Identities = 139/227 (61%), Positives = 161/227 (70%), Gaps = 19/227 (8%)
Frame = +2
Query: 98 GDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCA 277
GDEMTR+IW IK+KLI PFLD+++ YDLG+ NRD T D+VTI+ AEA KYNV IKCA
Sbjct: 42 GDEMTRVIWKWIKDKLIFPFLDLDIKYYDLGLPNRDATGDKVTIESAEATLKYNVAIKCA 101
Query: 278 TITP------------------DEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKN 403
TITP DE RV+EF L MWKSPNGTIRNIL GTVFRE IICKN
Sbjct: 102 TITPVLDTQFKFDFGRTIHEPTDEGRVKEFNLSAMWKSPNGTIRNILNGTVFREPIICKN 161
Query: 404 IPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGA-G 580
IPRLV GW KPI IGRHA DQY+ATD V+ G G L+++F E I+ V + GA G
Sbjct: 162 IPRLVPGWIKPICIGRHAFGDQYRATDTVIKGPGKLKLVFDGRE-EQIELDVFNFTGAGG 220
Query: 581 VALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFK 721
VAL+M+NTD SI FA +S A +++PLYLSTKNTILKKYDGRFK
Sbjct: 221 VALSMYNTDESIWAFAEASMNMAYQKRWPLYLSTKNTILKKYDGRFK 267
>UniRef50_Q0CXI1 Cluster: Isocitrate dehydrogenase, mitochondrial;
n=2; Eurotiomycetidae|Rep: Isocitrate dehydrogenase,
mitochondrial - Aspergillus terreus (strain NIH 2624)
Length = 466
Score = 264 bits (647), Expect = 2e-69
Identities = 123/179 (68%), Positives = 147/179 (82%), Gaps = 1/179 (0%)
Frame = +2
Query: 188 GMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILG 367
G+E RD+TDD+VT++ AEAIKKY VG+KCATITPDE RVEEFKLKKMW SPNGTIRNILG
Sbjct: 101 GIEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILG 160
Query: 368 GTVFREAIICKNIPRLVTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAI 547
GTVFRE I+ IPRLV GW KPIIIGRHA DQY+ATD V+PG G LE+++ P +G+
Sbjct: 161 GTVFREPIVIPAIPRLVPGWTKPIIIGRHAFGDQYRATDRVIPGPGKLELVYTPANGQPE 220
Query: 548 KHVVHEYK-GAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFK 721
V++++ G GVA++M+NTD SI FAHSSFK AL + PLY+STKNTILK+YDGRFK
Sbjct: 221 SVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKGLPLYMSTKNTILKRYDGRFK 279
>UniRef50_UPI0000F1EC8D Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 1 (NADP+), soluble; n=2; Danio rerio|Rep:
PREDICTED: similar to Isocitrate dehydrogenase 1
(NADP+), soluble - Danio rerio
Length = 206
Score = 249 bits (610), Expect = 5e-65
Identities = 112/140 (80%), Positives = 129/140 (92%), Gaps = 1/140 (0%)
Frame = +2
Query: 53 YNMS-KIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTI 229
+ MS KIKAG VV++ GDEMTR+IW+LIKEKLI P+L+++LH YDLGMENRD TDD+VT+
Sbjct: 6 FKMSQKIKAGSVVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTV 65
Query: 230 DCAEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIP 409
+ AEA+++YNVGIKCATITPDEKRVEEFKLK+MW+SPNGTIRNILGGTVFREAIICKNIP
Sbjct: 66 EAAEAVRRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIP 125
Query: 410 RLVTGWDKPIIIGRHAHADQ 469
RLV GW KPIIIGRHAH DQ
Sbjct: 126 RLVPGWIKPIIIGRHAHGDQ 145
>UniRef50_A5ZVX5 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus obeum ATCC 29174|Rep: Putative
uncharacterized protein - Ruminococcus obeum ATCC 29174
Length = 417
Score = 246 bits (601), Expect = 6e-64
Identities = 115/222 (51%), Positives = 153/222 (68%), Gaps = 1/222 (0%)
Frame = +2
Query: 59 MSKIK-AGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDC 235
M KI+ P+V++ GDEMTRI+W +IK++L+LPF+D+ YDLG+ R++TDDQVTID
Sbjct: 16 MEKIQMTTPLVEMDGDEMTRILWKMIKDELLLPFIDLNTEYYDLGLNYRNETDDQVTIDA 75
Query: 236 AEAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRL 415
AEA KKY V +KCATITP+ R++E+ LKKM+KSPNGTIR IL GTVFR I+ K I
Sbjct: 76 AEATKKYGVAVKCATITPNHARMDEYDLKKMYKSPNGTIRAILDGTVFRAPIVVKGIEPC 135
Query: 416 VTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAM 595
V W KPI + RHA+ D YK T+ + G +E+++ E GE + +V E+K GVA+ M
Sbjct: 136 VRNWKKPITLARHAYGDIYKNTEMYIDKPGKVELVYTSEDGEEKRSLVQEFKAPGVAMGM 195
Query: 596 FNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFK 721
N ASI FA S F +ALD K ++ K+TI K YD +FK
Sbjct: 196 HNMTASIESFARSCFNYALDTKQDVWFGAKDTISKTYDAKFK 237
>UniRef50_A5N5L9 Cluster: Idh; n=2; Bacteria|Rep: Idh - Clostridium
kluyveri DSM 555
Length = 401
Score = 244 bits (598), Expect = 1e-63
Identities = 113/220 (51%), Positives = 153/220 (69%), Gaps = 1/220 (0%)
Frame = +2
Query: 65 KIKAG-PVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAE 241
KIK P+V++ GDEMTRIIW +IKE L+ P++D++ YDLG+ R++T+D++TI+ A
Sbjct: 4 KIKMNVPLVEMDGDEMTRIIWKMIKELLLEPYIDLKTEYYDLGLVKRNETNDEITIEAAN 63
Query: 242 AIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVT 421
AIKKY VG+KCATITP+ KRV+E+ LK MWKSPNGTIR IL GTVFR II +I L+
Sbjct: 64 AIKKYGVGVKCATITPNAKRVKEYNLKSMWKSPNGTIRAILDGTVFRTPIIVNSIRPLMR 123
Query: 422 GWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAMFN 601
W+KPI + RHA+ D Y+ ++ V G +E++F E GE + +H + G GV + M N
Sbjct: 124 TWEKPITVARHAYGDVYRDVEYKVEEPGKMELVFTSEKGEETRQTLHVFNGPGVVMGMHN 183
Query: 602 TDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFK 721
D SI FA S F +ALD L+ ++K+TI K YD RFK
Sbjct: 184 LDKSIESFARSCFNYALDMNQNLWFASKDTISKTYDHRFK 223
>UniRef50_A2XVE4 Cluster: Putative uncharacterized protein; n=2;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. indica (Rice)
Length = 371
Score = 87.4 bits (207), Expect(2) = 1e-28
Identities = 41/69 (59%), Positives = 51/69 (73%)
Frame = +2
Query: 515 IIFKPESGEAIKHVVHEYKGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTI 694
I+ P+ E ++ V+ +KG GVAL+M+N D SI FA SS AL +K+PLYLSTKNTI
Sbjct: 30 ILSVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALSKKWPLYLSTKNTI 89
Query: 695 LKKYDGRFK 721
LKKYDGRFK
Sbjct: 90 LKKYDGRFK 98
Score = 62.1 bits (144), Expect(2) = 1e-28
Identities = 24/32 (75%), Positives = 30/32 (93%)
Frame = +2
Query: 326 MWKSPNGTIRNILGGTVFREAIICKNIPRLVT 421
MW+SPNGTIRNIL GTVFRE I+CKN+PR+++
Sbjct: 1 MWRSPNGTIRNILNGTVFREPILCKNVPRILS 32
Score = 59.3 bits (137), Expect = 9e-08
Identities = 28/37 (75%), Positives = 30/37 (81%)
Frame = +2
Query: 611 SIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFK 721
SI FA SS AL +K+PLYLSTKNTILKKYDGRFK
Sbjct: 158 SIRAFAESSMAMALSKKWPLYLSTKNTILKKYDGRFK 194
>UniRef50_Q00WM7 Cluster: COG0538: Isocitrate dehydrogenases; n=3;
Ostreococcus|Rep: COG0538: Isocitrate dehydrogenases -
Ostreococcus tauri
Length = 429
Score = 109 bits (261), Expect = 9e-23
Identities = 77/220 (35%), Positives = 112/220 (50%), Gaps = 7/220 (3%)
Frame = +2
Query: 62 SKIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIE-LHVYDLGMENRDKTDDQVTIDCA 238
SKI A P+V + G+EMT + DLI+ + I P +D+ +DL +NRD T+D+V D
Sbjct: 24 SKITAAPMVYVRGEEMTAYVMDLIRSRWIEPRVDVGGWETFDLRAKNRDDTEDRVLRDVI 83
Query: 239 EAIKKYNVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGG-TVFREAIICKNIPRL 415
EA K+ K T+TP +V+ L+K W SPNG +R G T+ R+ I +I +
Sbjct: 84 EAGKRIKAIFKEPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTI---HIDGV 140
Query: 416 VTGWDKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESG-EAIKHVV---HEYKGAGV 583
G+ KP++ RHA +Y A + G G L F P G +A K VV E
Sbjct: 141 ELGYKKPVLFERHAVGGEYSA-GYKNVGKGKLTTTFTPSEGPDAGKTVVVDEREIVDEEA 199
Query: 584 ALAMF-NTDASIIDFAHSSFKFALDRKYPLYLSTKNTILK 700
A+ + N ++ D A F L+ K Y+ TK T+ K
Sbjct: 200 AVVTYHNPYDNVHDLARFFFGRCLEAKVTPYVVTKKTVFK 239
>UniRef50_A3JDN6 Cluster: Isocitrate dehydrogenase; n=5;
Gammaproteobacteria|Rep: Isocitrate dehydrogenase -
Marinobacter sp. ELB17
Length = 582
Score = 98.7 bits (235), Expect = 1e-19
Identities = 69/231 (29%), Positives = 118/231 (51%), Gaps = 13/231 (5%)
Frame = +2
Query: 59 MSKIKA-GPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDC 235
++KI+ P+V + GDEM ++ ++ I +K + L IEL DL E+R T+ QV +
Sbjct: 2 VNKIQVESPLVILHGDEMAQVAFEEILKKFVTTRLAIELIEIDLSAEHRFLTNGQVIFEA 61
Query: 236 AEAIKKYNVGIKCATITPDEKRVE-------EFKLKKM----WKSPNGTIRNILGGTVFR 382
EA+KKY VG+K A +T + ++++ E ++ KSPNG IR +GG + R
Sbjct: 62 IEALKKYGVGVKNAGMTVNREQLDAMLEKHPELSQSRLDPLATKSPNGAIRKGIGGNITR 121
Query: 383 EAIICKNIPRLVTGW-DKPIIIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVV 559
E I +N+ W D+ I + + + + + G ++++F +SG ++
Sbjct: 122 EDIQFQNLRVRKPDWIDRDIDVDTMDNGGIKDSYNELSSSTGVVKLLFVGKSGNPVELHR 181
Query: 560 HEYKGAGVALAMFNTDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDG 712
+ K L N A + +AH F+ A+D K YL K+T++ YDG
Sbjct: 182 RDVKKGDPWLLATNDIADVKAWAHRFFQRAIDEKRDAYLGLKDTVIAGYDG 232
>UniRef50_Q2K7T8 Cluster: NADP-dependent isocitrate dehydrogenase
protein; n=1; Rhizobium etli CFN 42|Rep: NADP-dependent
isocitrate dehydrogenase protein - Rhizobium etli
(strain CFN 42 / ATCC 51251)
Length = 437
Score = 93.9 bits (223), Expect = 4e-18
Identities = 57/212 (26%), Positives = 108/212 (50%)
Frame = -2
Query: 718 ETTIVFLENCILSA*VQRVFSVQSKLE*RMSKVNNRCISVKHSQCYTCTLVLMNYMFYCL 539
E ++ LE+ +L V R F+ Q+ + +R + V H + + +
Sbjct: 202 EAAVIGLEDGVLGRQVDRPFAHQAVHHRGAGEFADRFVEVVHGHGNAGARRVEDLLLDDG 261
Query: 538 TRFRFEDYFKSTSTWDNKVSCFVLISMSMTSNDDGFVPPCYKSRYILANNSLPENSTTKN 359
F E + + +V C VL++ S+T++DD P ++R + A++ L E+ +N
Sbjct: 262 AVFTDELDRQLALAGELEVGCAVLVAESVTADDDRLRPAGNEARNVAADDRLAEDDAAEN 321
Query: 358 ITDGPIRAFPHFLQFKFFNSLLIRSYGRTFDAHIVFLYGLSTINCNLIISLITIFHTQVV 179
++D +RA PHFL+ +F ++ IR D VFL G+ ++ +L++ + IF +VV
Sbjct: 322 VSDRAVRALPHFLEIEFLDAGFIRRDRCALDTDAVFLDGVGGVDRHLVVGGVAIFDREVV 381
Query: 178 DM*FNVQERKNQLFFDKIPDYSGHFITKDVNN 83
+ V+ R +QL D++PD + HFI ++ +
Sbjct: 382 IVDIEVEIRMDQLILDELPDDACHFIAVEIGD 413
>UniRef50_Q5DBI8 Cluster: SJCHGC09598 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC09598 protein - Schistosoma
japonicum (Blood fluke)
Length = 129
Score = 84.2 bits (199), Expect = 3e-15
Identities = 51/91 (56%), Positives = 55/91 (60%)
Frame = -3
Query: 390 IASLKTVPPRILRMVPLGLFHIXXXXXXXXXXXSGVMVAHLMPTLYFFMASAQSIVT*SS 211
+ S KTVPPRILR+VP G HI SGVMVAHL+PTLYF +ASA SIVT S
Sbjct: 1 MGSRKTVPPRILRIVPFGDSHIFFKLNSLTRCSSGVMVAHLIPTLYFLIASAPSIVTWSL 60
Query: 210 VLSRFSIPKS*TCNSMSKKGRISFSLIRSQI 118
V SR PKS S S G IS IRS I
Sbjct: 61 VRSRLGRPKSKYLQSTSINGNISCCFIRSII 91
>UniRef50_A3K670 Cluster: NADP-dependent isocitrate dehydrogenase
protein; n=2; Rhodobacteraceae|Rep: NADP-dependent
isocitrate dehydrogenase protein - Sagittula stellata
E-37
Length = 459
Score = 77.0 bits (181), Expect = 4e-13
Identities = 49/213 (23%), Positives = 104/213 (48%)
Frame = -2
Query: 718 ETTIVFLENCILSA*VQRVFSVQSKLE*RMSKVNNRCISVKHSQCYTCTLVLMNYMFYCL 539
E +V LEN +L V R Q+ ++ KV +R + V H+ +++ L
Sbjct: 233 EPPVVGLENGVLGRQVHRPAQRQTVVQRGAGKVADRLVLVVHAHVDPGIGRVVDLALDHL 292
Query: 538 TRFRFEDYFKSTSTWDNKVSCFVLISMSMTSNDDGFVPPCYKSRYILANNSLPENSTTKN 359
F + + + ++ VL++ + ++ DG P +++R++ A++ L E+ ++
Sbjct: 293 AVGAFPFHRQLARRGEVEIRGLVLVAEGVPAHHDGRGPARHEARHVAADDRLAEDDAAQD 352
Query: 358 ITDGPIRAFPHFLQFKFFNSLLIRSYGRTFDAHIVFLYGLSTINCNLIISLITIFHTQVV 179
+ D + PH L+ +F ++LL+R R FD L ++ +L+ + + ++V
Sbjct: 353 VADRAVGRLPHLLETEFLDTLLVRGDRRAFDRDANLLRLFGGVDGDLVPGPVPLLDPEIV 412
Query: 178 DM*FNVQERKNQLFFDKIPDYSGHFITKDVNNR 80
V+ R++QLF D+ P +GH + +++R
Sbjct: 413 VKQVQVEVRQDQLFLDESPHDAGHLVAVHLHDR 445
>UniRef50_A4VDP7 Cluster: Putative uncharacterized protein; n=1;
Tetrahymena thermophila SB210|Rep: Putative
uncharacterized protein - Tetrahymena thermophila SB210
Length = 141
Score = 68.5 bits (160), Expect = 2e-10
Identities = 49/103 (47%), Positives = 59/103 (57%)
Frame = -3
Query: 360 ILRMVPLGLFHIXXXXXXXXXXXSGVMVAHLMPTLYFFMASAQSIVT*SSVLSRFSIPKS 181
+LR+VPLG HI S V+VAHL+PTL +A A S VT S V SRFSI +S
Sbjct: 1 MLRIVPLGEGHIFLSLNSLTRASSAVIVAHLIPTLCSRIAQAASKVTQSLVASRFSIERS 60
Query: 180 *TCNSMSKKGRISFSLIRSQIILVISSPRMSTTGPAFILDILY 52
S G +S SLI Q+I VISSP ST G F+ IL+
Sbjct: 61 QYLISAEINGNMSLSLIIFQMIRVISSPSKSTIG--FLTLILF 101
>UniRef50_Q4VCC2 Cluster: Isocitrate dehydrogenase; n=4;
Eukaryota|Rep: Isocitrate dehydrogenase - Saltugilia
latimeri
Length = 158
Score = 61.7 bits (143), Expect = 2e-08
Identities = 28/40 (70%), Positives = 32/40 (80%)
Frame = +2
Query: 602 TDASIIDFAHSSFKFALDRKYPLYLSTKNTILKKYDGRFK 721
TD SI FA +S A ++K+PLYLSTKNTILKKYDGRFK
Sbjct: 1 TDESIYSFAEASMTTAYEKKWPLYLSTKNTILKKYDGRFK 40
>UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Symbiobacterium thermophilum
Length = 357
Score = 52.0 bits (119), Expect = 1e-05
Identities = 46/152 (30%), Positives = 75/152 (49%), Gaps = 4/152 (2%)
Frame = +2
Query: 83 VVDILGDEMTRIIWDLIKEKLILPFLDIELHV--YDLGMENRDKTDDQVTIDCAEAIKKY 256
+V + GD+ + + + L + + LH+ YDL +ENR T ++V + A A++++
Sbjct: 7 IVVLEGDQTGQELLEEAVRLLSPDVIGLPLHLVRYDLSLENRRATSNRVVYEAAAAMREH 66
Query: 257 NVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVT--GWD 430
G+K ATITP E R + SPN +R + GTV + +P + T G
Sbjct: 67 GYGLKAATITP-EGRGDV-------GSPNAILRREIDGTVILRT--GRPLPGVETIGGIT 116
Query: 431 KPIIIGRHAHADQYKATDFVVPGAGTLEIIFK 526
PI + R A D Y+A ++ G G E F+
Sbjct: 117 APIAVVRMATEDAYEAKEW-REGEGDEERAFR 147
>UniRef50_Q40658 Cluster: Isocitrate dehydrogenase; n=1; Oryza
sativa|Rep: Isocitrate dehydrogenase - Oryza sativa
(Rice)
Length = 61
Score = 44.0 bits (99), Expect = 0.004
Identities = 17/26 (65%), Positives = 22/26 (84%)
Frame = +2
Query: 98 GDEMTRIIWDLIKEKLILPFLDIELH 175
GDEMTRI W IK+KLI PFLD++++
Sbjct: 36 GDEMTRIFWQSIKDKLIFPFLDLDIN 61
>UniRef50_Q5E609 Cluster: Putative uncharacterized protein; n=1;
Vibrio fischeri ES114|Rep: Putative uncharacterized
protein - Vibrio fischeri (strain ATCC 700601 / ES114)
Length = 326
Score = 35.1 bits (77), Expect = 1.8
Identities = 16/46 (34%), Positives = 24/46 (52%), Gaps = 2/46 (4%)
Frame = +2
Query: 179 YDLGMENRDKTDDQVTIDCA--EAIKKYNVGIKCATITPDEKRVEE 310
+ G + DK + +DC+ KYN+ +KCAT + DEK E
Sbjct: 86 FSQGFKYEDKVNPPKDVDCSVYHDYAKYNIEVKCATFSDDEKLKSE 131
>UniRef50_Q0SU98 Cluster: DNA/RNA helicase, SNF2; n=2; Clostridium
perfringens|Rep: DNA/RNA helicase, SNF2 - Clostridium
perfringens (strain SM101 / Type A)
Length = 1069
Score = 34.7 bits (76), Expect = 2.3
Identities = 29/148 (19%), Positives = 68/148 (45%), Gaps = 2/148 (1%)
Frame = -2
Query: 472 VLISMSMTSNDDGFVPPCYKSRYILANNSLPENSTTKNITDGPIRAFPHFLQF-KFFNSL 296
V +++++ +GF+ +K I+ NNS +N+ R +++ K F
Sbjct: 265 VPVALTLKEGKEGFILSHHKKFPIILNNSGDVMFFDRNLYLPRKRQLEYYIPIHKLFLKN 324
Query: 295 LIRSYGRTFDAHIVFLYGLSTINCNLIISL-ITIFHTQVVDM*FNVQERKNQLFFDKIPD 119
+Y ++ + L L I+ N+++ I +F +++ FN+ + K +++ + D
Sbjct: 325 NTITYKKSLENLRSLLEELKNISKNIVLDENIRVFKEKLMKTTFNLYKNKEKVYCNVKID 384
Query: 118 YSGHFITKDVNNRSSLYFRHIVSFYFYE 35
Y G+ I + + + + R + S + E
Sbjct: 385 YCGYIIDLIRDEKDNSFLRDLKSEKYIE 412
>UniRef50_A4WT53 Cluster: Sensor protein; n=3; Rhodobacter
sphaeroides|Rep: Sensor protein - Rhodobacter
sphaeroides ATCC 17025
Length = 890
Score = 34.7 bits (76), Expect = 2.3
Identities = 17/49 (34%), Positives = 28/49 (57%)
Frame = +2
Query: 440 IIGRHAHADQYKATDFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVA 586
I+G AHAD + +F+ GAG +++ KP + A+ V ++ G G A
Sbjct: 716 IVGATAHADPDRVPEFL--GAGMNDVLVKPITRSALFRAVRQFAGCGQA 762
>UniRef50_Q46FZ3 Cluster: Putative uncharacterized protein; n=1;
Methanosarcina barkeri str. Fusaro|Rep: Putative
uncharacterized protein - Methanosarcina barkeri (strain
Fusaro / DSM 804)
Length = 459
Score = 34.3 bits (75), Expect = 3.1
Identities = 18/52 (34%), Positives = 31/52 (59%)
Frame = +2
Query: 32 LFIEVERYNMSKIKAGPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDL 187
+F +E+Y S K P+V I+ +T ++W L+K LI P L + ++Y+L
Sbjct: 243 VFSAMEKYK-SFFKISPLVVIISSFITIVLWSLLKHDLIFPLLK-DNNLYEL 292
>UniRef50_UPI0000498AD5 Cluster: hypothetical membrane-spanning
protein; n=1; Entamoeba histolytica HM-1:IMSS|Rep:
hypothetical membrane-spanning protein - Entamoeba
histolytica HM-1:IMSS
Length = 453
Score = 33.1 bits (72), Expect = 7.1
Identities = 30/127 (23%), Positives = 57/127 (44%), Gaps = 3/127 (2%)
Frame = -2
Query: 568 VLMNYMFYCLTRFRFEDYFKSTSTWDNKVSCF--VLISMSMTSNDDGFVP-PCYKSRYIL 398
+L N +F + Y KS+S V+ ++ ++ + F+ P Y R +L
Sbjct: 24 LLKNDIFGYEKEIHYPIYKKSSSPIQQSVNLTQQIVNENTIPQSVKSFIQTPFYLERSVL 83
Query: 397 ANNSLPENSTTKNITDGPIRAFPHFLQFKFFNSLLIRSYGRTFDAHIVFLYGLSTINCNL 218
+ ++ + + P+R +F Q F N ++ Y R +D + +Y LST+ C +
Sbjct: 84 IGLLISWDTFSSFLLFTPLRIISYFYQLIFLNEKVVIHYKRIYD---ILMY-LSTLFCVI 139
Query: 217 IISLITI 197
II + I
Sbjct: 140 IIYQVDI 146
>UniRef50_Q142V0 Cluster: Putative uncharacterized protein; n=1;
Burkholderia xenovorans LB400|Rep: Putative
uncharacterized protein - Burkholderia xenovorans
(strain LB400)
Length = 274
Score = 33.1 bits (72), Expect = 7.1
Identities = 27/102 (26%), Positives = 44/102 (43%)
Frame = +2
Query: 77 GPVVDILGDEMTRIIWDLIKEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKY 256
G + GD M E+LI P LD + ++ T D + +D A Y
Sbjct: 28 GSALSFRGDRMDAKREASFFERLIEPMLDQLRRI--ASTTRKEYTVDDLKVDAFIAANDY 85
Query: 257 NVGIKCATITPDEKRVEEFKLKKMWKSPNGTIRNILGGTVFR 382
+ + P++++++E LKK+WK+ G N T FR
Sbjct: 86 QQELG-VELEPEDEKLQEAVLKKLWKA-FGKFANRTLRTAFR 125
>UniRef50_Q0WVR7 Cluster: TRNA synthase-like protein; n=7;
Eukaryota|Rep: TRNA synthase-like protein - Arabidopsis
thaliana (Mouse-ear cress)
Length = 540
Score = 32.7 bits (71), Expect = 9.4
Identities = 27/101 (26%), Positives = 43/101 (42%)
Frame = +2
Query: 134 KEKLILPFLDIELHVYDLGMENRDKTDDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEF 313
K+K++ V +GMEN D+ DD++ K+ + + EK+VE+F
Sbjct: 222 KKKVVAALGGKRSEVKRIGMENCDEDDDKLVFFDEVKEKEEKKKSEDDVVVVTEKKVEQF 281
Query: 314 KLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWDKP 436
K + KSPN + + G E + L WD P
Sbjct: 282 -FKGLTKSPNE--KGMASGGGDGEPFLVTRNGELPPRWDGP 319
>UniRef50_A5BB87 Cluster: Putative uncharacterized protein; n=1;
Vitis vinifera|Rep: Putative uncharacterized protein -
Vitis vinifera (Grape)
Length = 745
Score = 32.7 bits (71), Expect = 9.4
Identities = 13/35 (37%), Positives = 25/35 (71%), Gaps = 1/35 (2%)
Frame = +2
Query: 161 DIELHVYDLGMENRDKTDDQVTIDC-AEAIKKYNV 262
D+E++VYD+ +++RD+ D T+ C E I++Y +
Sbjct: 27 DVEVYVYDMIVKSRDRGDHLATLGCFFEMIRRYKL 61
>UniRef50_A2ERX8 Cluster: CAP-Gly domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: CAP-Gly domain containing
protein - Trichomonas vaginalis G3
Length = 474
Score = 32.7 bits (71), Expect = 9.4
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 3/64 (4%)
Frame = +2
Query: 425 WDKPIIIGRHAHADQYKAT---DFVVPGAGTLEIIFKPESGEAIKHVVHEYKGAGVALAM 595
WD P R H +YK D VP +G+ + G I ++HEY G +L++
Sbjct: 35 WDDP---SRGKHNGEYKGQKLFDVTVPNSGSFLRASSVKKGVKISEIIHEYSLVGGSLSL 91
Query: 596 FNTD 607
+T+
Sbjct: 92 DSTN 95
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 716,725,656
Number of Sequences: 1657284
Number of extensions: 15189822
Number of successful extensions: 40958
Number of sequences better than 10.0: 27
Number of HSP's better than 10.0 without gapping: 39367
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 40941
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 58677691418
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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