Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= maV30280
(627 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8; Bilateri... 242 6e-63
UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p... 238 7e-62
UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 167 3e-40
UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella ve... 151 1e-35
UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma... 149 5e-35
UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 136 4e-31
UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 129 5e-29
UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;... 118 9e-26
UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulato... 115 1e-24
UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulato... 114 1e-24
UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 111 1e-23
UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate... 111 2e-23
UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]... 100 3e-20
UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalyti... 91 2e-17
UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 91 3e-17
UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 86 8e-16
UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8; ... 81 2e-14
UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3; Bacteria... 77 3e-13
UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate dehydrog... 75 1e-12
UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1... 74 2e-12
UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2; Bacteria... 74 3e-12
UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep: C... 74 3e-12
UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9; Eut... 73 4e-12
UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3; Ricketts... 72 1e-11
UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 72 1e-11
UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68; Bacteri... 67 4e-10
UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependen... 67 4e-10
UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421, ... 65 1e-09
UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]... 61 2e-08
UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1; Ent... 61 2e-08
UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subuni... 57 3e-07
UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila melanogaster|... 57 3e-07
UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 56 5e-07
UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6; T... 55 2e-06
UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD] s... 54 3e-06
UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6; E... 52 1e-05
UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 47 2e-05
UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1; ... 50 3e-05
UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 50 3e-05
UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate dehydrog... 50 6e-05
UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8; E... 50 6e-05
UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;... 47 3e-04
UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3; P... 47 4e-04
UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependen... 44 0.002
UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependen... 44 0.003
UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella ve... 44 0.003
UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5; C... 43 0.005
UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9; B... 42 0.009
UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase, mitochond... 42 0.009
UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2; Alp... 42 0.012
UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyc... 42 0.012
UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp - Pa... 41 0.021
UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10; ... 41 0.028
UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC 1.1... 40 0.037
UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 40 0.049
UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase; n... 40 0.065
UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;... 39 0.085
UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5; E... 38 0.15
UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenas... 38 0.20
UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenas... 37 0.34
UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1; N... 37 0.45
UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: Leu... 36 0.60
UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit ... 36 0.60
UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular ... 36 1.1
UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1; S... 36 1.1
UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1; ... 36 1.1
UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1; V... 35 1.4
UniRef50_A4C445 Cluster: VCBS; n=1; Pseudoalteromonas tunicata D... 35 1.4
UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for ... 35 1.4
UniRef50_A5UWW1 Cluster: Agmatine deiminase; n=9; cellular organ... 35 1.8
UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2; T... 35 1.8
UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2... 34 2.4
UniRef50_A3Y262 Cluster: Phosphorelay protein; n=4; Vibrionales|... 34 2.4
UniRef50_P35484 Cluster: Dihydrolipoyl dehydrogenase; n=3; Achol... 34 2.4
UniRef50_UPI000065D57A Cluster: Putative polypeptide N-acetylgal... 34 3.2
UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2; Bacillacea... 34 3.2
UniRef50_Q8IC48 Cluster: Putative uncharacterized protein PF07_0... 34 3.2
UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;... 34 3.2
UniRef50_A3W960 Cluster: SCO1/SenC family protein; n=2; Roseovar... 33 4.2
UniRef50_A0E5I0 Cluster: Chromosome undetermined scaffold_8, who... 33 4.2
UniRef50_Q31IH6 Cluster: Erythronate-4-phosphate dehydrogenase; ... 33 4.2
UniRef50_Q89RM0 Cluster: Bll2743 protein; n=1; Bradyrhizobium ja... 33 5.6
UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;... 33 5.6
UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2; R... 33 7.4
UniRef50_O14122 Cluster: Cullin-4; n=1; Schizosaccharomyces pomb... 33 7.4
UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5; B... 32 9.8
UniRef50_Q0JFH8 Cluster: Os04g0102600 protein; n=1; Oryza sativa... 32 9.8
UniRef50_O16397 Cluster: Serpentine receptor, class h protein 19... 32 9.8
UniRef50_Q6BSN6 Cluster: Similar to Candida albicans CA2953; n=1... 32 9.8
UniRef50_Q2UB49 Cluster: Predicted protein; n=1; Aspergillus ory... 32 9.8
UniRef50_A4R0Z8 Cluster: Putative uncharacterized protein; n=1; ... 32 9.8
>UniRef50_Q0IEC8 Cluster: Isocitrate dehydrogenase; n=8;
Bilateria|Rep: Isocitrate dehydrogenase - Aedes aegypti
(Yellowfever mosquito)
Length = 393
Score = 242 bits (592), Expect = 6e-63
Identities = 111/169 (65%), Positives = 136/169 (80%)
Frame = +3
Query: 120 SDFDVQHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEV 299
S F++QHK P+ RK + IPKA YGGRH VTMLPGGGIGPE M YV+++F++ G P+DFEV
Sbjct: 24 SAFELQHKNPLQRKVEKIPKAHYGGRHTVTMLPGGGIGPELMNYVKEVFRFAGVPVDFEV 83
Query: 300 VDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNC 479
VDIDP + +DD++YAIT+IKRNGV LKGNIETKSEA + SRNVALRNELD+Y +L+C
Sbjct: 84 VDIDPASEGNDDLEYAITSIKRNGVALKGNIETKSEATGIISRNVALRNELDLYVNVLHC 143
Query: 480 KSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVEWVWSSQ*KWVTADN 626
KS+ + H+++DVVIIRQNTEGEYAMLEHESV V S K VT +N
Sbjct: 144 KSFNAIPAHHQNVDVVIIRQNTEGEYAMLEHESVRGVVESM-KVVTVEN 191
>UniRef50_Q8MT18 Cluster: RH49423p; n=10; Bilateria|Rep: RH49423p -
Drosophila melanogaster (Fruit fly)
Length = 402
Score = 238 bits (583), Expect = 7e-62
Identities = 112/169 (66%), Positives = 135/169 (79%), Gaps = 3/169 (1%)
Frame = +3
Query: 129 DVQHKTPVIRKQKL---IPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEV 299
DV H ++K+ IP AQYGGRHAVTMLPGGGIGPE MGYVR+IF+Y GAPIDFEV
Sbjct: 32 DVAHTKSALQKKVTGTDIPSAQYGGRHAVTMLPGGGIGPELMGYVREIFRYCGAPIDFEV 91
Query: 300 VDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNC 479
+DIDP+ + +DD+ YAIT+IKRNGV LKGNIETKS++ SRNVA+RNELD+Y +++C
Sbjct: 92 IDIDPSTEGNDDLDYAITSIKRNGVALKGNIETKSQSLTEVSRNVAIRNELDLYVNVVHC 151
Query: 480 KSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVEWVWSSQ*KWVTADN 626
KSYPG+ RH DIDVV+IRQNT+GEYAMLEHESV + S K VT +N
Sbjct: 152 KSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESM-KVVTVEN 199
>UniRef50_P51553 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=50;
Deuterostomia|Rep: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 393
Score = 167 bits (405), Expect = 3e-40
Identities = 81/158 (51%), Positives = 108/158 (68%), Gaps = 4/158 (2%)
Frame = +3
Query: 138 HKTP---VIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI 308
H+ P + +Q + P A+YGGRH VTM+PG GIGPE M +V+ +F++ P+DFE V +
Sbjct: 32 HEVPSRNIFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHV 91
Query: 309 DPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYV-TSRNVALRNELDMYAYILNCKS 485
D ++D++ AI I+RN V LKGNIET SRN LR LD+YA +++CKS
Sbjct: 92 SSNAD-EEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKS 150
Query: 486 YPGVATRHKDIDVVIIRQNTEGEYAMLEHESVEWVWSS 599
PGV TRHKDID++I+R+NTEGEY+ LEHESV V S
Sbjct: 151 LPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVES 188
>UniRef50_A7SJV9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 394
Score = 151 bits (367), Expect = 1e-35
Identities = 76/145 (52%), Positives = 102/145 (70%), Gaps = 6/145 (4%)
Frame = +3
Query: 174 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDD-----V 338
P A+YGGR+ VT++PG GIGPE + V+DIF++IG P+DFE +++ D+D
Sbjct: 43 PPARYGGRNTVTLIPGDGIGPEMVVAVQDIFRHIGVPVDFEELNLSGLDIKDEDSYLGAF 102
Query: 339 QYAITTIKRNGVGLKGNIETKSEAAY-VTSRNVALRNELDMYAYILNCKSYPGVATRHKD 515
AIT+IKRNGV +KGNI T +A S N+ LR LD++A I+ CKS PG+ TRH +
Sbjct: 103 NEAITSIKRNGVAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQTRHNN 162
Query: 516 IDVVIIRQNTEGEYAMLEHESVEWV 590
+D+VIIRQNTEGEY+ LEHE+V V
Sbjct: 163 VDLVIIRQNTEGEYSHLEHENVSGV 187
>UniRef50_Q567A6 Cluster: Isocitrate dehydrogenase 3 (NAD+) gamma;
n=1; Danio rerio|Rep: Isocitrate dehydrogenase 3 (NAD+)
gamma - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 289
Score = 149 bits (361), Expect = 5e-35
Identities = 68/151 (45%), Positives = 102/151 (67%), Gaps = 1/151 (0%)
Frame = +3
Query: 135 QHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDP 314
Q P + + P A+YGGRH VT++PG GIGPE + +VR++F++ P+DFEVV ++
Sbjct: 30 QRGKPTYSGRIIPPPAKYGGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNS 89
Query: 315 TMDNDDDVQYAITTIKRNGVGLKGNIETK-SEAAYVTSRNVALRNELDMYAYILNCKSYP 491
+ ++DD+ AI I+RNGV LKGNIET + SRN LR LD+YA +++C+S P
Sbjct: 90 SSTSEDDISNAIMAIRRNGVALKGNIETNHTMPPNHKSRNNLLRTSLDLYANVMHCQSLP 149
Query: 492 GVATRHKDIDVVIIRQNTEGEYAMLEHESVE 584
GV TRHK+ID++II + +E + E+E ++
Sbjct: 150 GVQTRHKNIDIIIILEKSEFSALLAENEKIK 180
>UniRef50_O94229 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1;
Kluyveromyces lactis|Rep: Isocitrate dehydrogenase [NAD]
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Length = 361
Score = 136 bits (329), Expect = 4e-31
Identities = 72/146 (49%), Positives = 100/146 (68%)
Frame = +3
Query: 162 QKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQ 341
++L+PK +YGGR+ VT++PG G+G E V IF+ PID+E +DI ++N ++VQ
Sbjct: 19 EQLLPK-KYGGRYTVTLIPGDGVGKEVTDSVVKIFENENIPIDWETIDISG-LENTENVQ 76
Query: 342 YAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDID 521
A+ ++KRN VGLKG T ++ S NVALR +LD++A + KS PGV TR +ID
Sbjct: 77 RAVESLKRNKVGLKGIWHTPADQTGHGSLNVALRKQLDIFANVALFKSIPGVKTRLNNID 136
Query: 522 VVIIRQNTEGEYAMLEHESVEWVWSS 599
+VIIR+NTEGEY+ LEHESV V S
Sbjct: 137 MVIIRENTEGEYSGLEHESVPGVVES 162
>UniRef50_P28834 Cluster: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=32;
Dikarya|Rep: Isocitrate dehydrogenase [NAD] subunit 1,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 360
Score = 129 bits (312), Expect = 5e-29
Identities = 68/146 (46%), Positives = 96/146 (65%)
Frame = +3
Query: 162 QKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQ 341
++ +PK +YGGR VT++PG G+G E VR IF+ PID+E ++I T D+ + V
Sbjct: 18 ERTLPK-KYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQT-DHKEGVY 75
Query: 342 YAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDID 521
A+ ++KRN +GLKG T ++ S NVALR +LD+YA + KS GV TR DID
Sbjct: 76 EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDID 135
Query: 522 VVIIRQNTEGEYAMLEHESVEWVWSS 599
+++IR+NTEGE++ LEHESV V S
Sbjct: 136 LIVIRENTEGEFSGLEHESVPGVVES 161
>UniRef50_Q0QHL0 Cluster: Isocitrate dehydrogenase (NAD+) 2; n=1;
Glossina morsitans morsitans|Rep: Isocitrate
dehydrogenase (NAD+) 2 - Glossina morsitans morsitans
(Savannah tsetse fly)
Length = 372
Score = 118 bits (285), Expect = 9e-26
Identities = 59/141 (41%), Positives = 93/141 (65%), Gaps = 5/141 (3%)
Frame = +3
Query: 174 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFE---VVDIDPTMDNDDDVQY 344
P A G R T++PG G+GPE + ++++FK P+DFE + +++P + ++
Sbjct: 32 PGALGGNRTTCTLIPGDGVGPELVQCLQEVFKSADVPVDFECYFLSEVNPVLSAK--LED 89
Query: 345 AITTIKRNGVGLKGNIETK--SEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDI 518
I +I++N V +KG + T S + S N+ LRNELD+YA +++ +S PGV TR++DI
Sbjct: 90 VIASIRKNKVCIKGVLATPDYSNVGELQSLNMKLRNELDLYANVVHARSLPGVKTRYQDI 149
Query: 519 DVVIIRQNTEGEYAMLEHESV 581
D+V+IR+ TEGEY+ LEHESV
Sbjct: 150 DIVVIREQTEGEYSALEHESV 170
>UniRef50_Q8LFC0 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 1, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 1) (NAD(+)-specific ICDH 1);
n=7; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 1, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 1) (NAD(+)-specific
ICDH 1) - Arabidopsis thaliana (Mouse-ear cress)
Length = 367
Score = 115 bits (276), Expect = 1e-24
Identities = 62/148 (41%), Positives = 89/148 (60%)
Frame = +3
Query: 156 RKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDD 335
R +P+ G AVT++PG GIGP V + + + API FE D+ M
Sbjct: 24 RSVTYMPRPGDGAPRAVTLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKYDVHGEMSRVPP 83
Query: 336 VQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD 515
+ +I++N V LKG ++T V+S NV LR ELD++A ++NC + PG+ TRH++
Sbjct: 84 E--VMESIRKNKVCLKGGLKTPVGGG-VSSLNVQLRKELDLFASLVNCFNLPGLPTRHEN 140
Query: 516 IDVVIIRQNTEGEYAMLEHESVEWVWSS 599
+D+V+IR+NTEGEYA LEHE V V S
Sbjct: 141 VDIVVIRENTEGEYAGLEHEVVPGVVES 168
>UniRef50_O81796 Cluster: Isocitrate dehydrogenase [NAD] regulatory
subunit 3, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 3) (NAD(+)-specific ICDH 3);
n=23; Eukaryota|Rep: Isocitrate dehydrogenase [NAD]
regulatory subunit 3, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 3) (NAD(+)-specific
ICDH 3) - Arabidopsis thaliana (Mouse-ear cress)
Length = 368
Score = 114 bits (275), Expect = 1e-24
Identities = 61/152 (40%), Positives = 91/152 (59%)
Frame = +3
Query: 144 TPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMD 323
T + R +P+ G VT++PG GIGP G V + + + AP+ FE ++ M
Sbjct: 21 TSLSRSITYMPRPGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVLGNMR 80
Query: 324 NDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT 503
+ I ++KRN V LKG + T V+S N+ LR ELD++A ++NC + PG+ T
Sbjct: 81 KVPEE--VIESVKRNKVCLKGGLATPVGGG-VSSLNMQLRKELDIFASLVNCINVPGLVT 137
Query: 504 RHKDIDVVIIRQNTEGEYAMLEHESVEWVWSS 599
RH+++D+V+IR+NTEGEY+ LEHE V V S
Sbjct: 138 RHENVDIVVIRENTEGEYSGLEHEVVPGVVES 169
>UniRef50_O43837 Cluster: Isocitrate dehydrogenase [NAD] subunit
beta, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=61;
Fungi/Metazoa group|Rep: Isocitrate dehydrogenase [NAD]
subunit beta, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) - Homo
sapiens (Human)
Length = 385
Score = 111 bits (268), Expect = 1e-23
Identities = 54/136 (39%), Positives = 86/136 (63%), Gaps = 3/136 (2%)
Frame = +3
Query: 192 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPT--MDNDDDVQYAITTIKR 365
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 106
Query: 366 NGVGLKGNIETKSE-AAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 542
N V + G I T E + S ++ LR +LD++A +++ KS PG TRH ++D+VIIR+
Sbjct: 107 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQ 166
Query: 543 TEGEYAMLEHESVEWV 590
TEGEY+ LEHES V
Sbjct: 167 TEGEYSSLEHESARGV 182
>UniRef50_UPI0000E25505 Cluster: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8; n=1; Pan
troglodytes|Rep: PREDICTED: similar to Isocitrate
dehydrogenase 3 (NAD+) beta isoform 8 - Pan troglodytes
Length = 331
Score = 111 bits (266), Expect = 2e-23
Identities = 54/136 (39%), Positives = 86/136 (63%), Gaps = 3/136 (2%)
Frame = +3
Query: 192 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPT--MDNDDDVQYAITTIKR 365
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 106
Query: 366 NGVGLKGNIETKSE-AAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 542
N V + G I T E + S ++ LR +LD++A +++ KS PG TRH ++D+VIIR+
Sbjct: 107 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQ 166
Query: 543 TEGEYAMLEHESVEWV 590
TEGEY+ LEHE E V
Sbjct: 167 TEGEYSSLEHECCEEV 182
>UniRef50_Q93714 Cluster: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH); n=6;
Eukaryota|Rep: Probable isocitrate dehydrogenase [NAD]
subunit alpha, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH) -
Caenorhabditis elegans
Length = 358
Score = 100 bits (239), Expect = 3e-20
Identities = 57/140 (40%), Positives = 79/140 (56%), Gaps = 3/140 (2%)
Frame = +3
Query: 189 GGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY---AITTI 359
G VT++PG GIGPE V+ IF+ API ++ VD+ P D + I +
Sbjct: 22 GDVRRVTLIPGDGIGPEISASVQKIFEAADAPIAWDPVDVTPVKGRDGVFRIPSRCIELM 81
Query: 360 KRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQ 539
N VGLKG +ET + S N+A+R E +YA + C+S G T + ++DVV IR+
Sbjct: 82 HANKVGLKGPLETPIGKGH-RSLNLAVRKEFSLYANVRPCRSLEGHKTLYDNVDVVTIRE 140
Query: 540 NTEGEYAMLEHESVEWVWSS 599
NTEGEY+ +EHE V V S
Sbjct: 141 NTEGEYSGIEHEIVPGVVQS 160
>UniRef50_Q8LG77 Cluster: Isocitrate dehydrogenase [NAD] catalytic
subunit 6, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase 6) (NAD(+)-specific ICDH 6);
n=10; cellular organisms|Rep: Isocitrate dehydrogenase
[NAD] catalytic subunit 6, mitochondrial precursor (EC
1.1.1.41) (Isocitric dehydrogenase 6) (NAD(+)-specific
ICDH 6) - Arabidopsis thaliana (Mouse-ear cress)
Length = 374
Score = 91.5 bits (217), Expect = 2e-17
Identities = 52/135 (38%), Positives = 77/135 (57%), Gaps = 4/135 (2%)
Frame = +3
Query: 207 TMLPGGGIGPECMGYVRDIFKYIGAPIDFEV----VDIDPTMDNDDDVQYAITTIKRNGV 374
T+ PG GIGPE V+ +F ID++ ++DP N + ++ +N V
Sbjct: 47 TLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRT-NSFLTWDNLQSVLKNKV 105
Query: 375 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGE 554
GLKG + T + S N+ LR EL++YA + C S PG TR+ D+D++ IR+NTEGE
Sbjct: 106 GLKGPMATPIGKGH-RSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGE 164
Query: 555 YAMLEHESVEWVWSS 599
Y+ LEH+ V+ V S
Sbjct: 165 YSGLEHQVVKGVVES 179
>UniRef50_P50213 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=62;
Eukaryota|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Homo sapiens
(Human)
Length = 366
Score = 90.6 bits (215), Expect = 3e-17
Identities = 58/169 (34%), Positives = 84/169 (49%), Gaps = 3/169 (1%)
Frame = +3
Query: 102 AAPATLSDFDVQHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGA 281
A PA +S V K + + GG VT++PG GIGPE V IF A
Sbjct: 2 AGPAWISK--VSRLLGAFHNPKQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKA 59
Query: 282 PIDFEVVDIDPTMDNDDDVQY---AITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNEL 452
PI +E ++ A ++ +N +GLKG ++T A + S N+ LR
Sbjct: 60 PIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAAGH-PSMNLLLRKTF 118
Query: 453 DMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVEWVWSS 599
D+YA + C S G T + D+++V IR+NTEGEY+ +EH V+ V S
Sbjct: 119 DLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQS 167
>UniRef50_P28241 Cluster: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=31; cellular
organisms|Rep: Isocitrate dehydrogenase [NAD] subunit 2,
mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Saccharomyces
cerevisiae (Baker's yeast)
Length = 369
Score = 85.8 bits (203), Expect = 8e-16
Identities = 46/129 (35%), Positives = 72/129 (55%), Gaps = 2/129 (1%)
Frame = +3
Query: 192 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV--QYAITTIKR 365
G++ V+ + G GIGPE V+ IF PI++E D+ P N A+ +I +
Sbjct: 35 GKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIPDPAVQSITK 94
Query: 366 NGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNT 545
N V LKG + T + S N+ LR ++A + KS G T ++++D+V+IR+NT
Sbjct: 95 NLVALKGPLATPIGKGH-RSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIRENT 153
Query: 546 EGEYAMLEH 572
EGEY+ +EH
Sbjct: 154 EGEYSGIEH 162
>UniRef50_Q2Q9C5 Cluster: Isocitrate dehydrogenase 3 gamma; n=8;
Eutheria|Rep: Isocitrate dehydrogenase 3 gamma - Homo
sapiens (Human)
Length = 88
Score = 81.0 bits (191), Expect = 2e-14
Identities = 38/85 (44%), Positives = 55/85 (64%), Gaps = 3/85 (3%)
Frame = +3
Query: 138 HKTP---VIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI 308
H+ P + +Q + P A+YGGRH VTM+PG GIGPE M +V+ +F++ P+DFE V +
Sbjct: 5 HEVPSRNIFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHV 64
Query: 309 DPTMDNDDDVQYAITTIKRNGVGLK 383
D ++D+ AI I+RN V LK
Sbjct: 65 SSNAD-EEDICNAIMAIRRNRVALK 88
>UniRef50_Q1IJA8 Cluster: Isocitrate dehydrogenase; n=3;
Bacteria|Rep: Isocitrate dehydrogenase - Acidobacteria
bacterium (strain Ellin345)
Length = 348
Score = 77.4 bits (182), Expect = 3e-13
Identities = 43/137 (31%), Positives = 74/137 (54%), Gaps = 3/137 (2%)
Frame = +3
Query: 198 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFE--VVDIDPTMDNDDDVQYAIT-TIKRN 368
+ +T++PG GIGPE + + G ++E + + + + +I+R
Sbjct: 3 YKITLIPGDGIGPEVTSAAVRVLEATGLKFEWESFAAGAEAYEKYKEYIPKELNESIERT 62
Query: 369 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTE 548
+GLKG + T + +S NV LR ++YA + ++ PGV TR+ +D+V++R+NTE
Sbjct: 63 RIGLKGPVTTPIGGGF-SSINVELRKRFELYANVRPIRNLPGVHTRYPGVDLVVVRENTE 121
Query: 549 GEYAMLEHESVEWVWSS 599
G Y+ +EHE V V S
Sbjct: 122 GLYSGIEHEVVPGVVES 138
>UniRef50_Q2JUI3 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase family protein; n=9; Bacteria|Rep:
Isopropylmalate/isohomocitrate dehydrogenase family
protein - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 368
Score = 75.4 bits (177), Expect = 1e-12
Identities = 44/131 (33%), Positives = 73/131 (55%), Gaps = 5/131 (3%)
Frame = +3
Query: 198 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDV-----QYAITTIK 362
+ VT++PG GIGPE + + + G +D E + ++ ++ + + +I+
Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEASG--VDLEWIRVEAGVEVIEKYGTPLPPQVLESIR 60
Query: 363 RNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 542
V +KG I T + S NVA+R ELD+YA + KS PG+ + +DID+V++R+N
Sbjct: 61 ETRVAIKGPIGTPVGTGF-RSVNVAIRKELDLYANLRPAKSLPGIKSPFQDIDLVVVREN 119
Query: 543 TEGEYAMLEHE 575
TE YA +E E
Sbjct: 120 TEDLYAGIEFE 130
>UniRef50_A6C2W4 Cluster: Isocitrate dehydrogenase, putative; n=1;
Planctomyces maris DSM 8797|Rep: Isocitrate
dehydrogenase, putative - Planctomyces maris DSM 8797
Length = 390
Score = 74.1 bits (174), Expect = 2e-12
Identities = 46/131 (35%), Positives = 71/131 (54%), Gaps = 4/131 (3%)
Frame = +3
Query: 198 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDID-PTMDNDDDV-QYAITTIKRNG 371
+ VT++PG G+GPE R G ID++V + ++ + V + +I+ N
Sbjct: 2 YKVTLIPGDGVGPEIAEATRKCVDATGVKIDWDVQECGIEVIEAEGGVPDRVMDSIRANK 61
Query: 372 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD--IDVVIIRQNT 545
+ LK I T + S NV LR EL +YA I CK+Y GV T D +D+V++R+NT
Sbjct: 62 IALKAPITTPIGKGF-RSVNVFLRQELGLYACIRPCKTYKGVRTYFADSNVDLVVVRENT 120
Query: 546 EGEYAMLEHES 578
E YA +E ++
Sbjct: 121 EDLYAGVEFQA 131
>UniRef50_Q7NC91 Cluster: Isocitrate dehydrogenase; n=2;
Bacteria|Rep: Isocitrate dehydrogenase - Gloeobacter
violaceus
Length = 359
Score = 73.7 bits (173), Expect = 3e-12
Identities = 42/129 (32%), Positives = 69/129 (53%), Gaps = 3/129 (2%)
Frame = +3
Query: 198 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY---AITTIKRN 368
+ VT++ G GIGPE R + G ++ VVD + I ++ +
Sbjct: 4 YRVTLIRGDGIGPEVTQAARIVLDATGIDFEWVVVDAGAEVMEKSGTPLPAPVIEAVRAS 63
Query: 369 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTE 548
+KG I T + + + S NVALR LD+YA + ++ PGV +R+ +ID+V++R+NTE
Sbjct: 64 DAAIKGPITTPAGSG-IRSVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRENTE 122
Query: 549 GEYAMLEHE 575
Y+ +E E
Sbjct: 123 DLYSGIEFE 131
>UniRef50_A0AMP6 Cluster: CG3483 protein; n=11; Sophophora|Rep:
CG3483 protein - Drosophila melanogaster (Fruit fly)
Length = 391
Score = 73.7 bits (173), Expect = 3e-12
Identities = 38/123 (30%), Positives = 68/123 (55%)
Frame = +3
Query: 204 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLK 383
VT++ G G+G E M V+++ + API+++V D D+DD + +++ N VG+K
Sbjct: 72 VTLINGEGVGRELMDAVQEVICAVKAPIEWDVHDEFKAKDSDDVSPEVLKSLRANKVGIK 131
Query: 384 GNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAM 563
G ++++ + R + +AY+ C G+ + + D DVVIIR EG+Y+
Sbjct: 132 GPVDSRHWQRQI-------RKQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEGDYSG 184
Query: 564 LEH 572
+EH
Sbjct: 185 IEH 187
>UniRef50_Q99855 Cluster: NAD+-isocitrate dehydrogenase; n=9;
Euteleostomi|Rep: NAD+-isocitrate dehydrogenase - Homo
sapiens (Human)
Length = 133
Score = 73.3 bits (172), Expect = 4e-12
Identities = 36/105 (34%), Positives = 63/105 (60%), Gaps = 3/105 (2%)
Frame = +3
Query: 192 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDID--PTMDNDDDVQYAITTIKR 365
G VTMLPG G+GPE M V+++FK P++F+ + M +++ ++ ++++K
Sbjct: 15 GAFPVTMLPGDGVGPELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 74
Query: 366 NGVGLKGNIETKSE-AAYVTSRNVALRNELDMYAYILNCKSYPGV 497
N V + G I T E + S ++ LR +LD++A +++ KS PGV
Sbjct: 75 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVIHVKSLPGV 119
>UniRef50_Q5P9Q1 Cluster: Isocitrate dehydrogenase; n=3;
Rickettsiales|Rep: Isocitrate dehydrogenase - Anaplasma
marginale (strain St. Maries)
Length = 488
Score = 71.7 bits (168), Expect = 1e-11
Identities = 49/132 (37%), Positives = 66/132 (50%), Gaps = 5/132 (3%)
Frame = +3
Query: 204 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQ----YAITTIKRNG 371
+T+ G G+GPE M V I K A + E VDI + A +I R
Sbjct: 10 ITVAYGDGVGPEIMEAVLFILKEARADVSIETVDIGHNQYKKEWTSGIAPSAWESISRTR 69
Query: 372 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSY-PGVATRHKDIDVVIIRQNTE 548
+ LK T + + S NVALR L +Y + C SY P V T+H D+DVVIIR+N E
Sbjct: 70 LLLKAPTMTPQGSGH-KSLNVALRQRLGLYVNVRPCVSYFPVVGTKHPDLDVVIIRENEE 128
Query: 549 GEYAMLEHESVE 584
Y+ +EH+ E
Sbjct: 129 DTYSGVEHKLSE 140
>UniRef50_P33197 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=5; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 496
Score = 71.7 bits (168), Expect = 1e-11
Identities = 44/133 (33%), Positives = 70/133 (52%), Gaps = 6/133 (4%)
Frame = +3
Query: 192 GRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDN----DDDVQYAITTI 359
GR +T++PG GIGPEC+ + + AP+ +EV + ++ Q I +I
Sbjct: 18 GRKLITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESI 77
Query: 360 KRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRH--KDIDVVII 533
++ V LKG +ET S NV LR + YA + + +P V T + + ID+V++
Sbjct: 78 RKTRVVLKGPLETPVGYG-EKSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVV 136
Query: 534 RQNTEGEYAMLEH 572
R+N E YA +EH
Sbjct: 137 RENVEDLYAGIEH 149
>UniRef50_A6T3U2 Cluster: Isocitrate dehydrogenase; n=68;
Bacteria|Rep: Isocitrate dehydrogenase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 349
Score = 66.9 bits (156), Expect = 4e-10
Identities = 43/127 (33%), Positives = 67/127 (52%), Gaps = 4/127 (3%)
Frame = +3
Query: 204 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDID-PTMDNDDDV--QYAITTIKRNGV 374
VT++PG GIGPE + V +F +G P +E ++ D+ Q + +I R G+
Sbjct: 12 VTLIPGDGIGPEIVDVVVRVFDALGNPFAWETQQAGVNALEKSGDLLPQTTLDSIGRTGL 71
Query: 375 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKS-YPGVATRHKDIDVVIIRQNTEG 551
LKG + T + S NV LR +YA + ++ PG R++ ID+V++R+N EG
Sbjct: 72 ALKGPLSTPIGGGF-RSVNVRLRETFQLYANVRPARTIVPG--GRYEKIDLVLVRENLEG 128
Query: 552 EYAMLEH 572
Y EH
Sbjct: 129 LYVGHEH 135
>UniRef50_A5CDH3 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=6; Rickettsiales|Rep: Isocitrate dehydrogenase,
NADP-dependent - Orientia tsutsugamushi (strain Boryong)
(Rickettsia tsutsugamushi)
Length = 519
Score = 66.9 bits (156), Expect = 4e-10
Identities = 49/129 (37%), Positives = 64/129 (49%), Gaps = 6/129 (4%)
Frame = +3
Query: 204 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITT-----IKRN 368
VT+ G GIGPE M V + K P+ E ++I + N Y IT I R
Sbjct: 7 VTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKY-YTYGITEDTWSQIFRT 65
Query: 369 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYIL-NCKSYPGVATRHKDIDVVIIRQNT 545
LKG + T Y S NV LR L +YA + +C +P V T +IDVVIIR+N
Sbjct: 66 KALLKGPVTTPQGGGY-KSLNVTLRKTLGLYANVRPSCSYFPFVNTSAPEIDVVIIRENE 124
Query: 546 EGEYAMLEH 572
E YA +E+
Sbjct: 125 EDLYAGIEY 133
>UniRef50_Q8N9Z6 Cluster: CDNA FLJ36019 fis, clone TESTI2016421,
highly similar to PROTEIN KINASE C-BINDING PROTEIN
NELL1; n=2; Homo sapiens|Rep: CDNA FLJ36019 fis, clone
TESTI2016421, highly similar to PROTEIN KINASE C-BINDING
PROTEIN NELL1 - Homo sapiens (Human)
Length = 355
Score = 64.9 bits (151), Expect = 1e-09
Identities = 27/54 (50%), Positives = 40/54 (74%)
Frame = +3
Query: 438 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVEWVWSS 599
L LD+YA +++ K+ P V T HKD+D++++ +NTEGEY+ LEHESV+ V S
Sbjct: 2 LHTTLDLYASVIHLKNLPNVETWHKDVDILVVWENTEGEYSNLEHESVKGVTES 55
>UniRef50_Q9LQK9 Cluster: Putative isocitrate dehydrogenase [NAD]
subunit-like 4 (Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4); n=1; Arabidopsis thaliana|Rep:
Putative isocitrate dehydrogenase [NAD] subunit-like 4
(Isocitric dehydrogenase-like protein 4)
(NAD(+)-specific ICDH 4) - Arabidopsis thaliana
(Mouse-ear cress)
Length = 294
Score = 61.3 bits (142), Expect = 2e-08
Identities = 39/116 (33%), Positives = 61/116 (52%)
Frame = +3
Query: 252 VRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRN 431
V + + AP+ FE I N + + +I++N V L G + S
Sbjct: 16 VHQVMDAMQAPVYFETYIIKGKNMNHLTWE-VVDSIRKNKVCLNGRVNN--------SLC 66
Query: 432 VALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVEWVWSS 599
R ELD++A +++C + G +RH+++D+V+IR+NTEGEYA EHE V V S
Sbjct: 67 GGARKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYAGREHEVVPGVIES 122
>UniRef50_UPI000049A356 Cluster: tartrate dehydrogenase; n=1;
Entamoeba histolytica HM-1:IMSS|Rep: tartrate
dehydrogenase - Entamoeba histolytica HM-1:IMSS
Length = 370
Score = 60.9 bits (141), Expect = 2e-08
Identities = 39/129 (30%), Positives = 69/129 (53%), Gaps = 7/129 (5%)
Frame = +3
Query: 195 RHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVD--IDPTMDNDDDVQY-AITTIKR 365
+H + ++PG GIG E M +F+ + PI + VD I + V I +K+
Sbjct: 10 QHKIIVIPGDGIGAEVMNEAEKMFQSLNLPIQRDYVDWGIQHYLKTGKVVPIDYIDQVKQ 69
Query: 366 NGVGLKGNI-ETKSEAAYVTSRN-VALRNELDMYAYILNCKSYPGVATRHK--DIDVVII 533
L G++ + ++ YVT + +R +LD + + K +PG+ T K +IDV+++
Sbjct: 70 YDAILLGSLGDPRTLPDYVTLEPLIQMRQQLDQFLCLRPAKHFPGIPTPLKKCEIDVLVV 129
Query: 534 RQNTEGEYA 560
R+N+EGEY+
Sbjct: 130 RENSEGEYS 138
>UniRef50_Q2VF40 Cluster: Isocitrate dehydrogenase 3 gamma subunit;
n=1; Pan troglodytes|Rep: Isocitrate dehydrogenase 3
gamma subunit - Pan troglodytes (Chimpanzee)
Length = 165
Score = 57.2 bits (132), Expect = 3e-07
Identities = 24/37 (64%), Positives = 30/37 (81%)
Frame = +3
Query: 174 PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAP 284
P A+YGGRH VTM+PG GIGPE M +V+ +F+Y GAP
Sbjct: 105 PSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRY-GAP 140
>UniRef50_Q4V533 Cluster: IP13250p; n=4; Drosophila
melanogaster|Rep: IP13250p - Drosophila melanogaster
(Fruit fly)
Length = 475
Score = 57.2 bits (132), Expect = 3e-07
Identities = 36/142 (25%), Positives = 73/142 (51%), Gaps = 1/142 (0%)
Frame = +3
Query: 168 LIPKAQYGGRHAVTMLPGGGI-GPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY 344
++PK++YGG + V+++ G I G + +V + P++ +V++ DD+ +
Sbjct: 53 VLPKSKYGGINTVSLVTGTTIIGQQGAQFVSSLLSSSRVPVEVQVIEAG----QDDEYFH 108
Query: 345 AITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDV 524
++ RN + + + +EA + + + N+LD+Y + +S+PG R +D+
Sbjct: 109 SVL---RNRTAVHVDNQADAEAK---QKALKICNDLDLYVFKTRTRSFPGFKCRFPGVDI 162
Query: 525 VIIRQNTEGEYAMLEHESVEWV 590
+I QN G + LE+ VE V
Sbjct: 163 QLIGQNNMGIFNELEYSPVEGV 184
>UniRef50_P80046 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=38; Bacteria|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Synechocystis sp. (strain PCC 6803)
Length = 475
Score = 56.4 bits (130), Expect = 5e-07
Identities = 29/77 (37%), Positives = 43/77 (55%), Gaps = 3/77 (3%)
Frame = +3
Query: 348 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHK---DI 518
+T IK GV +KG + T + S NVALR D+Y + C+ YPG + HK +
Sbjct: 89 LTAIKEYGVAIKGPLTTPVGGG-IRSLNVALRQIFDLYTCVRPCRYYPGTPSPHKTPEKL 147
Query: 519 DVVIIRQNTEGEYAMLE 569
D+++ R+NTE Y +E
Sbjct: 148 DIIVYRENTEDIYLGIE 164
>UniRef50_P50455 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Thermoprotei|Rep: 3-isopropylmalate dehydrogenase -
Sulfolobus tokodaii
Length = 337
Score = 54.8 bits (126), Expect = 2e-06
Identities = 43/130 (33%), Positives = 66/130 (50%), Gaps = 7/130 (5%)
Frame = +3
Query: 204 VTMLPGGGIGPECMGYVRDIFKYIGA----PIDF-EVVDIDPTMDNDDDV--QYAITTIK 362
V ++ G GIGPE + + I I PI++ EV D + + + ++ I
Sbjct: 5 VALIQGDGIGPEIVSKSKRILAKINELYSLPIEYIEVEAGDRALARYGEALPKDSLKIID 64
Query: 363 RNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQN 542
+ + LKG + AA V V LR DMYA I KS PG+ T++ ++D++I+R+N
Sbjct: 65 KADIILKGPVG--ESAADVV---VKLRQIYDMYANIRPAKSIPGIDTKYGNVDILIVREN 119
Query: 543 TEGEYAMLEH 572
TE Y EH
Sbjct: 120 TEDLYKGFEH 129
>UniRef50_UPI0000F3457C Cluster: Isocitrate dehydrogenase [NAD]
subunit gamma, mitochondrial precursor (EC 1.1.1.41)
(Isocitric dehydrogenase) (NAD(+)-specific ICDH).; n=1;
Bos taurus|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial precursor (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH). - Bos Taurus
Length = 260
Score = 54.0 bits (124), Expect = 3e-06
Identities = 24/49 (48%), Positives = 35/49 (71%)
Frame = +3
Query: 453 DMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVEWVWSS 599
D+ A ++ +S P V TRHK+ID++++R NTEGEY+ LE ES+ V S
Sbjct: 17 DLCANVVQFESQPRVETRHKNIDILVVRDNTEGEYSNLEDESMNRVVES 65
>UniRef50_Q58130 Cluster: 3-isopropylmalate dehydrogenase; n=6;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanococcus jannaschii
Length = 333
Score = 51.6 bits (118), Expect = 1e-05
Identities = 47/141 (33%), Positives = 66/141 (46%), Gaps = 10/141 (7%)
Frame = +3
Query: 198 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVG 377
H + ++ G GIG E + + + G P +F + D+V KR G
Sbjct: 2 HKICVIEGDGIGKEVVPATIQVLEATGLPFEFVYAEAG------DEVY------KRTGKA 49
Query: 378 L-KGNIETKSE-------AAYVTSRNVA--LRNELDMYAYILNCKSYPGVATRHKDIDVV 527
L + IET + AA T+ +V LR+ LD YA I K+Y GV DID V
Sbjct: 50 LPEETIETALDCDAVLFGAAGETAADVIVKLRHILDTYANIRPVKAYKGVKCLRPDIDYV 109
Query: 528 IIRQNTEGEYAMLEHESVEWV 590
I+R+NTEG Y +E E E +
Sbjct: 110 IVRENTEGLYKGIEAEIDEGI 130
>UniRef50_P41566 Cluster: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
gamma, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 106
Score = 46.8 bits (106), Expect(2) = 2e-05
Identities = 24/58 (41%), Positives = 30/58 (51%)
Frame = +3
Query: 159 KQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDD 332
+Q + P A+YGG VTM PG G GPE M V P+DFE V + D +D
Sbjct: 3 QQTIPPSAKYGGILTVTMSPGDGDGPELMLTVXXXXXSACVPVDFEEVVVSSNADEED 60
Score = 23.8 bits (49), Expect(2) = 2e-05
Identities = 8/20 (40%), Positives = 14/20 (70%)
Frame = +3
Query: 438 LRNELDMYAYILNCKSYPGV 497
+R LD+YA +++CK G+
Sbjct: 61 IRTSLDLYANVIHCKLGDGL 80
>UniRef50_A5DIP7 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 173
Score = 50.4 bits (115), Expect = 3e-05
Identities = 42/104 (40%), Positives = 51/104 (49%)
Frame = -3
Query: 496 TPG*DLQFRM*AYMSSSFLRATLRDVT*AASLLVSMLPFSPTPFLLMVVIAYWTSSSLSI 317
TPG L A +S+SFL AT D+ + V+ +PF+PT FL A T LS
Sbjct: 8 TPGMFLIKTNEAKISNSFLNATFNDLP-DDPVGVNKIPFNPTLFLFNDSTASATPVPLS- 65
Query: 316 VGSMSTTSKSIGAPMYLNMSRTYPMHSGPIPPPGSMVTA*RPPY 185
ST S S+G L M T + S PIP PG VT PPY
Sbjct: 66 KPETSTVSHSMGTFSDLKMVLTESVISLPIPSPGMRVTVYLPPY 109
>UniRef50_Q5HNL1 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=73; cellular organisms|Rep:
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) - Staphylococcus epidermidis (strain ATCC 35984 /
RP62A)
Length = 422
Score = 50.4 bits (115), Expect = 3e-05
Identities = 30/80 (37%), Positives = 46/80 (57%), Gaps = 3/80 (3%)
Frame = +3
Query: 339 QYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---RH 509
Q + TIK + +KG + T + S NVALR ELD++ + + + GV + R
Sbjct: 76 QETLETIKEYLIAVKGPLTTPIGGG-IRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRP 134
Query: 510 KDIDVVIIRQNTEGEYAMLE 569
+D+D+VI R+NTE YA +E
Sbjct: 135 EDVDMVIFRENTEDIYAGIE 154
>UniRef50_A7DN42 Cluster: Isopropylmalate/isohomocitrate
dehydrogenase; n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Isopropylmalate/isohomocitrate dehydrogenase -
Candidatus Nitrosopumilus maritimus SCM1
Length = 337
Score = 49.6 bits (113), Expect = 6e-05
Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 7/127 (5%)
Frame = +3
Query: 198 HAVTMLPGGGIGPECMGYVRDIFKYIGAPID--FEVVDI---DPTMDNDDDV--QYAITT 356
+ ++++ G GIGPE + + I +D F + + D ++ ++
Sbjct: 2 YKISLITGDGIGPELSDSAVSVLETIHDKLDLKFGITKLSAGDKALEQTGKALPDDTVSA 61
Query: 357 IKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIR 536
IK++ +K + AA V V LR LD+YA I KSYP + DID+VI+R
Sbjct: 62 IKQSDACMKAPVG--ESAADVI---VVLRRMLDLYANIRPAKSYPHMPALRDDIDMVIVR 116
Query: 537 QNTEGEY 557
+NTE Y
Sbjct: 117 ENTEDLY 123
>UniRef50_O27441 Cluster: 3-isopropylmalate dehydrogenase; n=8;
Euryarchaeota|Rep: 3-isopropylmalate dehydrogenase -
Methanobacterium thermoautotrophicum
Length = 329
Score = 49.6 bits (113), Expect = 6e-05
Identities = 34/118 (28%), Positives = 50/118 (42%)
Frame = +3
Query: 204 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLK 383
+ ++PG GIG E M I + ++F D T++ G
Sbjct: 6 IAVIPGDGIGVEVMEAALHILNTLDLDLEFIHADAGDACLKRTGTALPEETLEAVGEARA 65
Query: 384 GNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEY 557
E+A V LR E D++A + KS PGV + D+D VI+R+NTE Y
Sbjct: 66 TLFGAAGESA--ADVIVRLRREFDLFANLRPVKSLPGVPCLYPDLDFVIVRENTEDLY 121
>UniRef50_UPI00015BAE7F Cluster: 3-isopropylmalate dehydrogenase;
n=1; Ignicoccus hospitalis KIN4/I|Rep: 3-isopropylmalate
dehydrogenase - Ignicoccus hospitalis KIN4/I
Length = 343
Score = 47.2 bits (107), Expect = 3e-04
Identities = 38/131 (29%), Positives = 64/131 (48%), Gaps = 8/131 (6%)
Frame = +3
Query: 204 VTMLPGGGIGPECMGYVRDIFKYIGA----PIDFEVVDI-DPTMDNDDDV--QYAITTIK 362
V ++ G GIGPE +G + + I P++F V+ D + + + + +
Sbjct: 4 VAVIEGDGIGPEVVGATLKVLEKIRETFKLPLEFVFVEAGDRAKEKYGEALPKESYERLL 63
Query: 363 RNGVGLKGNI-ETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQ 539
R LKG + ET ++ V LR ELD++A I K PGV +++D++I+R+
Sbjct: 64 RADAILKGPVGETAADVI------VRLRRELDLFANIRPAKVLPGVPALKENVDLIIVRE 117
Query: 540 NTEGEYAMLEH 572
N E Y E+
Sbjct: 118 NIEDLYVGAEN 128
>UniRef50_Q89RM2 Cluster: 3-isopropylmalate dehydrogenase; n=3;
Proteobacteria|Rep: 3-isopropylmalate dehydrogenase -
Bradyrhizobium japonicum
Length = 365
Score = 46.8 bits (106), Expect = 4e-04
Identities = 38/142 (26%), Positives = 60/142 (42%), Gaps = 11/142 (7%)
Frame = +3
Query: 168 LIPKAQYGGR-HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQY 344
+ P Q+ G + +LPG GIGPE + + + + + + Q+
Sbjct: 2 IAPALQFWGNVMQLIVLPGDGIGPEITTATSGVLRAASERFQLNLRLEEHAVGHASLKQF 61
Query: 345 AITT------IKRNGVGL----KGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPG 494
T I R GL + K EA + + R LD+YA + ++Y G
Sbjct: 62 GTTVRPELLDIVRGADGLILGPTATFDFKDEAHGEINPSRHFRKNLDLYANVRPARTYAG 121
Query: 495 VATRHKDIDVVIIRQNTEGEYA 560
R D D+V++R+NTEG YA
Sbjct: 122 RPGRLGDFDLVVVRENTEGFYA 143
>UniRef50_A7D1A5 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=2; Archaea|Rep: Isocitrate dehydrogenase,
NADP-dependent - Halorubrum lacusprofundi ATCC 49239
Length = 463
Score = 44.4 bits (100), Expect = 0.002
Identities = 28/80 (35%), Positives = 45/80 (56%), Gaps = 3/80 (3%)
Frame = +3
Query: 348 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD---I 518
++ I+ + V +KG + T A + S NVALR LD+YA + GV + K+ +
Sbjct: 131 VSAIRDHRVAIKGPLTTPVGAGF-RSLNVALRKTLDLYANVRPTYYLDGVPSPVKNPEKM 189
Query: 519 DVVIIRQNTEGEYAMLEHES 578
D++ R+NTE YA +E E+
Sbjct: 190 DMITFRENTEDVYAGIEWEA 209
>UniRef50_A5URE6 Cluster: Isocitrate dehydrogenase, NADP-dependent;
n=4; Chloroflexaceae|Rep: Isocitrate dehydrogenase,
NADP-dependent - Roseiflexus sp. RS-1
Length = 453
Score = 44.0 bits (99), Expect = 0.003
Identities = 27/70 (38%), Positives = 41/70 (58%), Gaps = 3/70 (4%)
Frame = +3
Query: 372 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---RHKDIDVVIIRQN 542
VG+KG + T + S NVALR LD+Y + + + GV + R + +D+VI R+N
Sbjct: 95 VGIKGPLTTPVGRG-IRSLNVALRQLLDLYVCLRPVRYFQGVPSPVKRPELVDMVIFREN 153
Query: 543 TEGEYAMLEH 572
TE YA +E+
Sbjct: 154 TEDIYAGIEY 163
>UniRef50_A7T3D9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 419
Score = 44.0 bits (99), Expect = 0.003
Identities = 27/80 (33%), Positives = 43/80 (53%), Gaps = 3/80 (3%)
Frame = +3
Query: 339 QYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHK-- 512
Q + +K V +KG + T + S NVALR +LD+Y + + + GV + K
Sbjct: 88 QETLDAVKDYVVSIKGPLTTPVGGG-IRSLNVALRQQLDLYVCLRPVRWFEGVPSPVKKP 146
Query: 513 -DIDVVIIRQNTEGEYAMLE 569
D+D+ I R+N+E YA +E
Sbjct: 147 GDVDMTIFRENSEDIYAGIE 166
>UniRef50_A5US63 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Chloroflexi (class)|Rep: 3-isopropylmalate dehydrogenase
- Roseiflexus sp. RS-1
Length = 362
Score = 43.2 bits (97), Expect = 0.005
Identities = 37/128 (28%), Positives = 57/128 (44%), Gaps = 7/128 (5%)
Frame = +3
Query: 198 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI--DPTMDNDDDVQYAITTIKRNG 371
+ + ++PG GIG E + + + G P FE D + + + A T R
Sbjct: 6 YTILVIPGDGIGREVIPAAVAVLRATGLPFHFENADAGWECFQRQGEALPSATLTAARAA 65
Query: 372 VG-LKGNIETKS-EAAYVTSRNVALRNELDMYAYI---LNCKSYPGVATRHKDIDVVIIR 536
L G + + A S V LR ELD+YA I + G R + +D+V++R
Sbjct: 66 DAILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPVFDDLPENGSNPRRRKVDLVVVR 125
Query: 537 QNTEGEYA 560
+NTE YA
Sbjct: 126 ENTEDVYA 133
>UniRef50_Q0SI24 Cluster: 3-isopropylmalate dehydrogenase; n=9;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Rhodococcus sp. (strain RHA1)
Length = 365
Score = 42.3 bits (95), Expect = 0.009
Identities = 19/41 (46%), Positives = 28/41 (68%)
Frame = +3
Query: 438 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYA 560
+R D++A I +S GVA+ D+D+VI+R+NTEG YA
Sbjct: 102 VRKRFDLFANIRPARSLEGVASTVPDMDLVIVRENTEGLYA 142
>UniRef50_P40495 Cluster: Homoisocitrate dehydrogenase,
mitochondrial precursor; n=33; Dikarya|Rep:
Homoisocitrate dehydrogenase, mitochondrial precursor -
Saccharomyces cerevisiae (Baker's yeast)
Length = 371
Score = 42.3 bits (95), Expect = 0.009
Identities = 34/136 (25%), Positives = 66/136 (48%), Gaps = 9/136 (6%)
Frame = +3
Query: 204 VTMLPGGGIGPECMGYVRDIFKYIGAP--IDFEVVDIDPTMDNDDDVQYA-----ITTIK 362
+ ++PG GIG E + + + + + + + F +D+ + A + +K
Sbjct: 26 IGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLK 85
Query: 363 RNGVG-LKGNIETKS-EAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIR 536
G L G +++ + + +S VALR E+ ++A + KS G + K ID+VI+R
Sbjct: 86 EQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEG--EKGKPIDMVIVR 143
Query: 537 QNTEGEYAMLEHESVE 584
+NTE Y +E ++
Sbjct: 144 ENTEDLYIKIEKTYID 159
>UniRef50_Q2CJC3 Cluster: Isopropylmalate dehydrogenase; n=2;
Alphaproteobacteria|Rep: Isopropylmalate dehydrogenase -
Oceanicola granulosus HTCC2516
Length = 363
Score = 41.9 bits (94), Expect = 0.012
Identities = 17/38 (44%), Positives = 25/38 (65%)
Frame = +3
Query: 438 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEG 551
LR D++A + +SYPG+ DID+VI+R+N EG
Sbjct: 95 LRKGFDLFANVRPTRSYPGIGCLFDDIDLVIVRENNEG 132
>UniRef50_Q0X0C1 Cluster: Putative dehydrogenase; n=1; Streptomyces
lasaliensis|Rep: Putative dehydrogenase - Streptomyces
lasaliensis
Length = 362
Score = 41.9 bits (94), Expect = 0.012
Identities = 39/141 (27%), Positives = 66/141 (46%), Gaps = 14/141 (9%)
Frame = +3
Query: 180 AQYGGRHAVT---MLPGGGIGPECMGYVRDIFKYIGAPIDFEVVD---IDPTMDNDDDVQ 341
A+ G AVT ++PG GIGPE + D+ +G +++D D + + +
Sbjct: 11 ARAGSETAVTTIAVIPGDGIGPEVIEPALDVLDALGLGTRTDILDHVNADTYLRTGEALT 70
Query: 342 YA-ITTIKRNGVGLKGNI--ETKSEAAYVTSRNVALRNELDMY-----AYILNCKSYPGV 497
+ + I+ + L G + + +YV LR ELD+Y A + + + P
Sbjct: 71 GSDLDRIRSSEAALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLR 130
Query: 498 ATRHKDIDVVIIRQNTEGEYA 560
+ ID VI+R+NTEG Y+
Sbjct: 131 DPARRAIDCVIVRENTEGLYS 151
>UniRef50_Q9CKK6 Cluster: Idp; n=2; Pasteurellaceae|Rep: Idp -
Pasteurella multocida
Length = 415
Score = 41.1 bits (92), Expect = 0.021
Identities = 30/87 (34%), Positives = 46/87 (52%), Gaps = 3/87 (3%)
Frame = +3
Query: 348 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT--RHKD-I 518
+T I+ V +KG + T + S NVA+R LD+Y + + Y G + +H + +
Sbjct: 89 MTFIRDYHVAIKGPLMTPVGGG-IRSLNVAMRQGLDLYNCLRPIRYYDGTPSPVKHPELV 147
Query: 519 DVVIIRQNTEGEYAMLEHESVEWVWSS 599
D+VI R+N+E YA VEWV S
Sbjct: 148 DMVIFRENSEDIYA-----GVEWVAGS 169
>UniRef50_O29627 Cluster: 3-isopropylmalate dehydrogenase; n=10;
cellular organisms|Rep: 3-isopropylmalate dehydrogenase
- Archaeoglobus fulgidus
Length = 326
Score = 40.7 bits (91), Expect = 0.028
Identities = 31/126 (24%), Positives = 56/126 (44%), Gaps = 4/126 (3%)
Frame = +3
Query: 204 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDI-DPTMDNDDDV--QYAITTIKRNGV 374
+ ++PG GIG E M I + + P ++ D D ++ + +++
Sbjct: 4 IVVIPGDGIGKEVMEAAMLILEKLDLPFEYSYYDAGDEALEKYGKALPDETLEACRKSDA 63
Query: 375 GLKGNI-ETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEG 551
L G ET ++ V LR EL +A + K+ G+ + +D+V++R+NTE
Sbjct: 64 VLFGAAGETAADVI------VRLRRELGTFANVRPAKAIEGIECLYPGLDIVVVRENTEC 117
Query: 552 EYAMLE 569
Y E
Sbjct: 118 LYMGFE 123
>UniRef50_P56063 Cluster: Isocitrate dehydrogenase [NADP] (EC
1.1.1.42) (Oxalosuccinate decarboxylase) (IDH)
(NADP(+)-specific ICDH); n=504; root|Rep: Isocitrate
dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) -
Helicobacter pylori (Campylobacter pylori)
Length = 425
Score = 40.3 bits (90), Expect = 0.037
Identities = 25/76 (32%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Frame = +3
Query: 348 ITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSY--PGVATRHKDID 521
I I V +KG + T + S NVALR ++D+Y + + Y P + +D
Sbjct: 99 IEAINHYKVSIKGPLTTPIGEGF-RSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVD 157
Query: 522 VVIIRQNTEGEYAMLE 569
+VI R+N+E YA +E
Sbjct: 158 MVIFRENSEDIYAGIE 173
>UniRef50_A0B6L6 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Methanosaeta thermophila PT|Rep: Isocitrate
dehydrogenase (NAD(+)) - Methanosaeta thermophila
(strain DSM 6194 / PT) (Methanothrixthermophila (strain
DSM 6194 / PT))
Length = 375
Score = 39.9 bits (89), Expect = 0.049
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 3/76 (3%)
Frame = +3
Query: 345 AITTIKRNGVGLKGNIETKSEA---AYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD 515
A+ +K+ V LKG + T + + S NVA+R ELD++A + V+ +
Sbjct: 75 ALDALKKCHVILKGPLTTPKKGDPWPNLESANVAMRRELDLFANVRP------VSIPSEG 128
Query: 516 IDVVIIRQNTEGEYAM 563
ID V R+NTEGEY +
Sbjct: 129 IDWVFFRENTEGEYVL 144
>UniRef50_Q51945 Cluster: Tartrate dehydrogenase/decarboxylase;
n=106; Bacteria|Rep: Tartrate
dehydrogenase/decarboxylase - Pseudomonas putida
Length = 365
Score = 39.5 bits (88), Expect = 0.065
Identities = 22/47 (46%), Positives = 28/47 (59%), Gaps = 5/47 (10%)
Frame = +3
Query: 441 RNELDMYAYILNCKSYPGV----ATRHK-DIDVVIIRQNTEGEYAML 566
R E D Y I + +PGV A R DID V++R+NTEGEY+ L
Sbjct: 98 RREFDQYVNIRPVRLFPGVPCALANRKVGDIDFVVVRENTEGEYSSL 144
>UniRef50_Q9V1I8 Cluster: LeuB-2 3-isopropylmalate dehydrogenase;
n=4; Thermococcaceae|Rep: LeuB-2 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 346
Score = 39.1 bits (87), Expect = 0.085
Identities = 38/128 (29%), Positives = 59/128 (46%), Gaps = 7/128 (5%)
Frame = +3
Query: 198 HAVTMLPGGGIGPECM-------GYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITT 356
+ V ++ G GIGPE + V D ++ FEV + ++DD++
Sbjct: 2 YRVAVIKGDGIGPEVVDSAIRVVNSVTDRIRFYEFEGGFEVFKRIGSPISEDDLK----E 57
Query: 357 IKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIR 536
I++ L G T S V LR ELD+YA N + P ++ ++VI+R
Sbjct: 58 IRKMDAILFGATTTPFNVPGYRSLIVTLRKELDLYA---NLRIIPDLSNGK---EIVIVR 111
Query: 537 QNTEGEYA 560
+NTEG YA
Sbjct: 112 ENTEGLYA 119
>UniRef50_Q0W1Q6 Cluster: 2-isopropylmalate dehydrogenase; n=5;
Euryarchaeota|Rep: 2-isopropylmalate dehydrogenase -
Uncultured methanogenic archaeon RC-I
Length = 324
Score = 38.3 bits (85), Expect = 0.15
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 3/125 (2%)
Frame = +3
Query: 204 VTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYA---ITTIKRNGV 374
+ +LPG GIG E + ++ K +F V++ + V + + T+K
Sbjct: 3 IAVLPGDGIGREVVPVAHEVLKVALPDAEFLHVEVGNERYVREGVSMSPADLETVKACDC 62
Query: 375 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGE 554
L G I + Y S + LR ELD+YA I +S P ++ R ++ I R+N+E
Sbjct: 63 VLFGAITSPPGKPY-RSIILTLRKELDLYANIRPFRSCP-ISPR--KVNFTIYRENSEDL 118
Query: 555 YAMLE 569
Y +E
Sbjct: 119 YMGIE 123
>UniRef50_Q8TI91 Cluster: Isocitrate/isopropylmalate dehydrogenase
family protein; n=6; Archaea|Rep:
Isocitrate/isopropylmalate dehydrogenase family protein
- Methanosarcina acetivorans
Length = 342
Score = 37.9 bits (84), Expect = 0.20
Identities = 25/121 (20%), Positives = 51/121 (42%), Gaps = 5/121 (4%)
Frame = +3
Query: 210 MLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITT-----IKRNGV 374
++ G G+GPE + + + G ++F + + + + + +
Sbjct: 7 VIKGDGVGPELVEAMLKVANAAGTDVEFVMCEAGAGWWEEHGGNSLVPDETWQILDSSDA 66
Query: 375 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGE 554
KG T S V++R + D+YA + K++P D+++V +R+ TEG
Sbjct: 67 CFKGPTTTPGGIGSPRSVAVSIRRKYDLYANVRPIKTFPNSNAPLGDVEMVCVREGTEGL 126
Query: 555 Y 557
Y
Sbjct: 127 Y 127
>UniRef50_A6G3V7 Cluster: Probable 3-isopropylmalate dehydrogenase;
n=1; Plesiocystis pacifica SIR-1|Rep: Probable
3-isopropylmalate dehydrogenase - Plesiocystis pacifica
SIR-1
Length = 368
Score = 37.1 bits (82), Expect = 0.34
Identities = 28/72 (38%), Positives = 35/72 (48%), Gaps = 10/72 (13%)
Frame = +3
Query: 375 GLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATR----HKDI------DV 524
G G + K S + R L++YA + K YPGV R HK I D+
Sbjct: 65 GTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAGKVDM 124
Query: 525 VIIRQNTEGEYA 560
VIIR+NTEG YA
Sbjct: 125 VIIRENTEGLYA 136
>UniRef50_A1SM34 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-isopropylmalate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 478
Score = 36.7 bits (81), Expect = 0.45
Identities = 37/137 (27%), Positives = 54/137 (39%), Gaps = 15/137 (10%)
Frame = +3
Query: 192 GRHAVTMLPGGGIGPECMGYVRDIFKYIG-APIDFEVVDIDPTMDN--------DDDVQY 344
G + ++PG GIGPE + + A + FE D + D V
Sbjct: 130 GSLRLAVIPGDGIGPEVTAEALKVLEVASPAGVKFEQTRYDLGAERYLATGEVLPDSVLE 189
Query: 345 AIT---TIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---R 506
I I VG K N + LR ELD Y + + +PGVA+
Sbjct: 190 EIREHDAILLGAVGGKPNDPNLPPGILERGLLLRLRFELDHYVNLRPSRIFPGVASPLAN 249
Query: 507 HKDIDVVIIRQNTEGEY 557
++D V++R+ TEG Y
Sbjct: 250 PGEVDFVVVREGTEGPY 266
>UniRef50_Q89GM4 Cluster: LeuB protein; n=2; Rhizobiales|Rep: LeuB
protein - Bradyrhizobium japonicum
Length = 359
Score = 36.3 bits (80), Expect = 0.60
Identities = 20/46 (43%), Positives = 29/46 (63%), Gaps = 3/46 (6%)
Frame = +3
Query: 432 VALRNELDMYAYILNCKSYPGVAT---RHKDIDVVIIRQNTEGEYA 560
+ LR +LD++A + K Y GV + R ID VI+R+N+EG YA
Sbjct: 93 LTLRFKLDLFANVRPIKLYKGVPSPLGRPGPIDYVIVRENSEGLYA 138
>UniRef50_P56471 Cluster: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH); n=1; Sus
scrofa|Rep: Isocitrate dehydrogenase [NAD] subunit
alpha, mitochondrial (EC 1.1.1.41) (Isocitric
dehydrogenase) (NAD(+)-specific ICDH) - Sus scrofa (Pig)
Length = 90
Score = 36.3 bits (80), Expect = 0.60
Identities = 18/37 (48%), Positives = 20/37 (54%)
Frame = +3
Query: 189 GGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEV 299
GG VT++PG GIGPE V IF API V
Sbjct: 2 GGVKTVTLIPGDGIGPEISAAVMKIFDAAKAPIQANV 38
>UniRef50_Q62EL0 Cluster: Tartrate dehydrogenase; n=60; cellular
organisms|Rep: Tartrate dehydrogenase - Burkholderia
mallei (Pseudomonas mallei)
Length = 361
Score = 35.5 bits (78), Expect = 1.1
Identities = 34/137 (24%), Positives = 59/137 (43%), Gaps = 16/137 (11%)
Frame = +3
Query: 198 HAVTMLPGGGIG----PECMGYVRDIFKYIGA-----PIDFEVVDIDPTMDN--DDDVQY 344
+ + ++PG GIG PE + + + + G PI++ D DD +
Sbjct: 6 YRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMPDDWKT 65
Query: 345 AITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGV-----ATRH 509
++ + G G ET + + + R E D Y + + + GV +
Sbjct: 66 QLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGRKA 125
Query: 510 KDIDVVIIRQNTEGEYA 560
DID +I+R+NTEGEY+
Sbjct: 126 GDIDFMIVRENTEGEYS 142
>UniRef50_A4FEJ6 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
3-isopropylmalate dehydrogenase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 407
Score = 35.5 bits (78), Expect = 1.1
Identities = 37/132 (28%), Positives = 57/132 (43%), Gaps = 14/132 (10%)
Frame = +3
Query: 204 VTMLPGGGIGPECMGYVRDIFKYI-GAPIDFEVVDIDPTMDNDDDVQYAIT--TIKR--- 365
+ ++PG GIGPE + ++ + G ++ D D A++ T++R
Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGRDVELRFTSEDAGADAFRRTGSAMSAATLERIRT 68
Query: 366 --NGVGLKGNIETKS----EAAYVTSRNVALRNELDMYAYILNCKSYPGVAT--RHKDID 521
+GV LKG + + LR LD YA + PGV R +D
Sbjct: 69 RYHGV-LKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTAVD 127
Query: 522 VVIIRQNTEGEY 557
VI+R+NTEG Y
Sbjct: 128 YVIVRENTEGLY 139
>UniRef50_A5DIP6 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 230
Score = 35.5 bits (78), Expect = 1.1
Identities = 19/48 (39%), Positives = 25/48 (52%)
Frame = -2
Query: 572 VFQHSIFTFCVLSDNNNINVLMPGRNARVRFTVQNVSIHVQFISESHI 429
VFQ IFTF V SD +N L +A F S ++QF S+ +I
Sbjct: 87 VFQSRIFTFSVFSDEGKVNALQTRLDAGNVFDQDQRSKNIQFFSQRNI 134
>UniRef50_A6PN62 Cluster: 3-isopropylmalate dehydrogenase; n=1;
Victivallis vadensis ATCC BAA-548|Rep: 3-isopropylmalate
dehydrogenase - Victivallis vadensis ATCC BAA-548
Length = 369
Score = 35.1 bits (77), Expect = 1.4
Identities = 35/137 (25%), Positives = 54/137 (39%), Gaps = 17/137 (12%)
Frame = +3
Query: 198 HAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAIT-------- 353
+ + +LPG G GPE + + G F + N Y T
Sbjct: 5 YKIAVLPGDGTGPEVIAEAVKVLDAAGRKFGFTT---EKEYYNWGGAHYLATGETLPADA 61
Query: 354 --TIKRNGVGLKGNIETKSEAAYVTSRNVAL--RNELDMYAYILNCKSYPGVAT-----R 506
+ R+ L G I V + + L R +LD Y + K +PGV T +
Sbjct: 62 KEQLARHDAVLLGAIGHPDVKPGVLEKGILLKLRFDLDQYINLRPVKLFPGVETPLANKK 121
Query: 507 HKDIDVVIIRQNTEGEY 557
+DID V++R+N+ G Y
Sbjct: 122 PEDIDYVVVRENSGGVY 138
>UniRef50_A4C445 Cluster: VCBS; n=1; Pseudoalteromonas tunicata
D2|Rep: VCBS - Pseudoalteromonas tunicata D2
Length = 1600
Score = 35.1 bits (77), Expect = 1.4
Identities = 19/66 (28%), Positives = 30/66 (45%), Gaps = 2/66 (3%)
Frame = +3
Query: 114 TLSDFDVQHKTPVIRKQKLI--PKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPI 287
T+++ QH T ++ +L+ P+A Y G +T G G GYV K + A I
Sbjct: 1330 TVTNISAQHGTVTLQNGQLVYTPQASYSGADEITYTVSDGKGGSAQGYVEVTIKPVNATI 1389
Query: 288 DFEVVD 305
V+
Sbjct: 1390 SLIAVN 1395
>UniRef50_A0XZN2 Cluster: Isocitrate dehydrogenase, specific for
NADP+; n=3; Alteromonadales|Rep: Isocitrate
dehydrogenase, specific for NADP+ - Alteromonadales
bacterium TW-7
Length = 422
Score = 35.1 bits (77), Expect = 1.4
Identities = 21/89 (23%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Frame = +3
Query: 321 DNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVA 500
D D Q I ++ + +KG + T + S NVALR E+D++ + K + +
Sbjct: 81 DGDWFPQETIQAVRACKIAIKGPLTTPLGGGF-RSLNVALRQEMDLFVNMRTIKGFSALP 139
Query: 501 TRHKD---IDVVIIRQNTEGEYAMLEHES 578
+ K+ ++ ++R ++E Y+ +E ++
Sbjct: 140 SPLKNPFLTNITVLRDSSEDVYSGIEWQA 168
>UniRef50_A5UWW1 Cluster: Agmatine deiminase; n=9; cellular
organisms|Rep: Agmatine deiminase - Roseiflexus sp. RS-1
Length = 348
Score = 34.7 bits (76), Expect = 1.8
Identities = 18/77 (23%), Positives = 40/77 (51%), Gaps = 1/77 (1%)
Frame = +3
Query: 138 HKTPVIRKQKLIPK-AQYGGRHAVTMLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDP 314
++ P + ++++ + Y G + L G +G + G++ D+ +++ VV+ DP
Sbjct: 180 NRNPHLTREQIEQRLCDYLGVSNILWLGDGIVGDDTDGHIDDLARFVAPDTVVTVVESDP 239
Query: 315 TMDNDDDVQYAITTIKR 365
T +N D +Q + +KR
Sbjct: 240 TDENYDALQENLRRLKR 256
>UniRef50_Q6L2P9 Cluster: Isocitrate dehydrogenase [NADP]; n=2;
Thermoplasmatales|Rep: Isocitrate dehydrogenase [NADP] -
Picrophilus torridus
Length = 392
Score = 34.7 bits (76), Expect = 1.8
Identities = 36/123 (29%), Positives = 55/123 (44%), Gaps = 10/123 (8%)
Frame = +3
Query: 219 GGGIGPECMGYVRDIFKYIGA----PIDFEVV---DIDPTMDNDDDVQYAITTIKRNGVG 377
G GIGPE M R + A I ++ + D + D + +I I V
Sbjct: 24 GDGIGPEIMDATRKVVDAATAMEKKSIAWKEILLGDRAEELKGDRFPEESIKAINDYRVL 83
Query: 378 LKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKD---IDVVIIRQNTE 548
LK + T + S NV +R LD+YA I K PG+ + K+ +++ I R+NT+
Sbjct: 84 LKAPLNTPVGKGF-KSINVRIRMLLDLYANIRPVKFMPGLESPLKNPEKVNLTIFRENTD 142
Query: 549 GEY 557
Y
Sbjct: 143 DLY 145
>UniRef50_Q9RTT2 Cluster: Isocitrate dehydrogenase, putative; n=2;
Deinococcus|Rep: Isocitrate dehydrogenase, putative -
Deinococcus radiodurans
Length = 333
Score = 34.3 bits (75), Expect = 2.4
Identities = 16/44 (36%), Positives = 29/44 (65%)
Frame = +3
Query: 438 LRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLE 569
LR + ++YA + K+ P V ++++D+VI+R+NT+G Y E
Sbjct: 89 LRQKYNLYANVRPTKTRP-VPHSYENVDLVIVRENTQGLYVEQE 131
>UniRef50_A3Y262 Cluster: Phosphorelay protein; n=4;
Vibrionales|Rep: Phosphorelay protein - Vibrio sp.
MED222
Length = 114
Score = 34.3 bits (75), Expect = 2.4
Identities = 12/27 (44%), Positives = 21/27 (77%)
Frame = -2
Query: 299 HFEVNRSTDVFEYVANVSHALRTDTAS 219
H E+N+ +D +Y+A++SHAL++ AS
Sbjct: 39 HLELNKESDTSKYLADISHALKSSAAS 65
>UniRef50_P35484 Cluster: Dihydrolipoyl dehydrogenase; n=3;
Acholeplasmataceae|Rep: Dihydrolipoyl dehydrogenase -
Acholeplasma laidlawii
Length = 336
Score = 34.3 bits (75), Expect = 2.4
Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 2/105 (1%)
Frame = +3
Query: 93 SSKAAPATLSDFDVQHKTPVIRKQKLIPKAQYGGRHAVTMLPGGGIGPECMGYVRDIFKY 272
SS P + K V+ ++L+ Y ++ ++ GG IG E +F
Sbjct: 141 SSAVVPPIPGVKEAYEKGIVVTSRELLNVKNYP--KSIVIVGGGVIGVE----FATVFNS 194
Query: 273 IGAPIDF-EVVD-IDPTMDNDDDVQYAITTIKRNGVGLKGNIETK 401
G+ + E++D I PTMD+D V YA T+KR+G+ + E K
Sbjct: 195 FGSKVTIIEMMDGILPTMDDDIRVAYA-KTLKRDGIEILTKAEVK 238
>UniRef50_UPI000065D57A Cluster: Putative polypeptide
N-acetylgalactosaminyltransferase-like protein 3 (EC
2.4.1.41) (Protein-UDP
acetylgalactosaminyltransferase-like protein 3)
(UDP-GalNAc:polypeptide
N-acetylgalactosaminyltransferase- like protein 3)
(Polypeptide GalNAc transferase-lik; n=1; Takifugu
rubripes|Rep: Putative polypeptide
N-acetylgalactosaminyltransferase-like protein 3 (EC
2.4.1.41) (Protein-UDP
acetylgalactosaminyltransferase-like protein 3)
(UDP-GalNAc:polypeptide
N-acetylgalactosaminyltransferase- like protein 3)
(Polypeptide GalNAc transferase-lik - Takifugu rubripes
Length = 605
Score = 33.9 bits (74), Expect = 3.2
Identities = 20/59 (33%), Positives = 30/59 (50%)
Frame = +1
Query: 265 SNTSVLLLTSKWWTLTQRWTMMMMSNML*RPLRGTVWG*RATLKPKVRQPM*HHVMWLS 441
S+ V +LTS W +T+ M+MSN L R W R LK R P+ ++W++
Sbjct: 115 SSYGVAILTSAWLKVTEEKKKMLMSNFLKR----LTWPFRECLKTLKRLPLCTWIIWMN 169
>UniRef50_A3IE78 Cluster: Tartrate dehydrogenase; n=2;
Bacillaceae|Rep: Tartrate dehydrogenase - Bacillus sp.
B14905
Length = 362
Score = 33.9 bits (74), Expect = 3.2
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 3/44 (6%)
Frame = +3
Query: 438 LRNELDMYAYILNCKSYPGVATR---HKDIDVVIIRQNTEGEYA 560
+R Y KS PG+++ DID VI R+N EGEY+
Sbjct: 94 IRKNFQQYVNFRPIKSLPGISSPLAGGNDIDFVIFRENAEGEYS 137
>UniRef50_Q8IC48 Cluster: Putative uncharacterized protein
PF07_0004; n=1; Plasmodium falciparum 3D7|Rep: Putative
uncharacterized protein PF07_0004 - Plasmodium
falciparum (isolate 3D7)
Length = 964
Score = 33.9 bits (74), Expect = 3.2
Identities = 24/102 (23%), Positives = 49/102 (48%), Gaps = 2/102 (1%)
Frame = +3
Query: 285 IDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNE-LDMY 461
I++E+++++ D+D+DV+Y + I+ + +E K E N L+ E L+
Sbjct: 172 IEYEIIEVEVDDDDDEDVEYEVIEIEVDDDEEVELLEDKEEKIEEVKENKQLKVESLEKK 231
Query: 462 AY-ILNCKSYPGVATRHKDIDVVIIRQNTEGEYAMLEHESVE 584
I YP V K+ID +++N Y + ++++
Sbjct: 232 PLEIKTTPKYPFVTDEQKEIDP--LKKNEIKSYDPFKRDTIK 271
>UniRef50_Q9UZ05 Cluster: LeuB-1 3-isopropylmalate dehydrogenase;
n=4; cellular organisms|Rep: LeuB-1 3-isopropylmalate
dehydrogenase - Pyrococcus abyssi
Length = 354
Score = 33.9 bits (74), Expect = 3.2
Identities = 35/131 (26%), Positives = 57/131 (43%), Gaps = 12/131 (9%)
Frame = +3
Query: 204 VTMLPGGGIGPECMGYVRDIFKYIG--APIDFEVVDI----DPTMDNDDDV-QYAITTIK 362
+ ++PG GIG E + + K + + + FE + + + + + +AI K
Sbjct: 5 IAVIPGDGIGKEVVAEGLKVLKKLEELSRVSFEFKEYPFGAEHYLKTGETLPDWAIEEFK 64
Query: 363 RNGVGLKGNIETKSEAAYVTSRNVAL--RNELDMYAYILNCKSYPGVATRHKD---IDVV 527
+ G I + R + L R ELD+Y + K Y T K ID+V
Sbjct: 65 KFDAIYFGAIGDPRVKPGILERGILLKMRFELDLYVNLRPVKLYHPRLTPLKGKNKIDIV 124
Query: 528 IIRQNTEGEYA 560
+R+NTEG YA
Sbjct: 125 FVRENTEGLYA 135
>UniRef50_A3W960 Cluster: SCO1/SenC family protein; n=2;
Roseovarius|Rep: SCO1/SenC family protein - Roseovarius
sp. 217
Length = 217
Score = 33.5 bits (73), Expect = 4.2
Identities = 18/56 (32%), Positives = 29/56 (51%)
Frame = +3
Query: 243 MGYVRDIFKYIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGNIETKSEA 410
M ++ + G + ++ IDP +D + + A+T I + VGL GN E SEA
Sbjct: 90 MADAAEVLERRGISVSPVLITIDPVLDTVETMGPALTKISADLVGLTGNREALSEA 145
>UniRef50_A0E5I0 Cluster: Chromosome undetermined scaffold_8, whole
genome shotgun sequence; n=1; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_8,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 293
Score = 33.5 bits (73), Expect = 4.2
Identities = 25/92 (27%), Positives = 42/92 (45%), Gaps = 6/92 (6%)
Frame = +3
Query: 318 MDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRN------ELDMYAYILNC 479
M N D Y I ++ +GL +IE S +++ N+ L+N + +L+C
Sbjct: 1 MQNCDLNSYQIGLSRKQQLGLYSDIEYSSSRYSLSTNNLNLKNLQNLKNRISQLQSVLSC 60
Query: 480 KSYPGVATRHKDIDVVIIRQNTEGEYAMLEHE 575
K G TR K +D N + Y++ EH+
Sbjct: 61 KYRKGSLTRSK-LDDSTNLTNDKSTYSLQEHK 91
>UniRef50_Q31IH6 Cluster: Erythronate-4-phosphate dehydrogenase;
n=1; Thiomicrospira crunogena XCL-2|Rep:
Erythronate-4-phosphate dehydrogenase - Thiomicrospira
crunogena (strain XCL-2)
Length = 375
Score = 33.5 bits (73), Expect = 4.2
Identities = 17/52 (32%), Positives = 33/52 (63%), Gaps = 3/52 (5%)
Frame = +3
Query: 453 DMYAYILNCKSYPG--VATRH-KDIDVVIIRQNTEGEYAMLEHESVEWVWSS 599
++++++ N S PG + T H ++ D +I+R T+ A+LEH +V +V S+
Sbjct: 18 ELFSHLGNVISLPGKEINTEHLQNADALIVRSRTQVNSALLEHTNVSFVGST 69
>UniRef50_Q89RM0 Cluster: Bll2743 protein; n=1; Bradyrhizobium
japonicum|Rep: Bll2743 protein - Bradyrhizobium
japonicum
Length = 364
Score = 33.1 bits (72), Expect = 5.6
Identities = 32/137 (23%), Positives = 58/137 (42%), Gaps = 12/137 (8%)
Frame = +3
Query: 222 GGIGPECMGYVRDIFK----YIGAPIDFEVVDIDPTMDNDDDVQYAITTIKRNGVGLKGN 389
G + C Y D+ + G ++D+D T+ +++YA+ T+K +G+GL+ +
Sbjct: 124 GRLARTCNEYAADMMRDHPGRFGLFATLSMLDVDATLK---EIEYALDTLKADGIGLQSS 180
Query: 390 IETK--SEAAYVTSRNVALRNELDMYAY--ILNCKSYPGVATRHKDIDVVIIRQNTEGEY 557
K AAY R + +Y + + +C S V T I+V T
Sbjct: 181 YGDKWLGNAAYRPVFEELNRRKAVVYVHPLVASCCSALSVGTFPAVIEVPHDTTRTVTSL 240
Query: 558 ----AMLEHESVEWVWS 596
A H ++W++S
Sbjct: 241 LLSGAFARHRDIKWLFS 257
>UniRef50_A7DP63 Cluster: Isocitrate dehydrogenase (NAD(+)); n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep: Isocitrate
dehydrogenase (NAD(+)) - Candidatus Nitrosopumilus
maritimus SCM1
Length = 343
Score = 33.1 bits (72), Expect = 5.6
Identities = 31/127 (24%), Positives = 51/127 (40%), Gaps = 7/127 (5%)
Frame = +3
Query: 210 MLPGGGIGPECMGYVRDIFKYIGAPIDFEVVDIDPTM---DNDDDVQY----AITTIKRN 368
++ G GIGPE + + + K + + + + D Y + ++
Sbjct: 7 VMKGDGIGPEVVDSMLRVLKECNFQSELILCEAGSEQWDKNGRKDASYIPDVTMKILEET 66
Query: 369 GVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVATRHKDIDVVIIRQNTE 548
KG T S V LR + D+YA I K+Y + T + +D V R+ TE
Sbjct: 67 DCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRL-TPDRKLDCVCFREATE 125
Query: 549 GEYAMLE 569
G Y +E
Sbjct: 126 GLYTGVE 132
>UniRef50_A0P1S6 Cluster: 3-isopropylmalate dehydrogenase; n=2;
Rhodobacterales|Rep: 3-isopropylmalate dehydrogenase -
Stappia aggregata IAM 12614
Length = 369
Score = 32.7 bits (71), Expect = 7.4
Identities = 18/48 (37%), Positives = 28/48 (58%), Gaps = 5/48 (10%)
Frame = +3
Query: 423 SRNVALRNELDMYAYILNCKSYPGVATRHKD-----IDVVIIRQNTEG 551
S ++ LR+ +YA + K+YP R D ID+VI+R++TEG
Sbjct: 87 SPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRAAGIDLVILRESTEG 134
>UniRef50_O14122 Cluster: Cullin-4; n=1; Schizosaccharomyces
pombe|Rep: Cullin-4 - Schizosaccharomyces pombe (Fission
yeast)
Length = 734
Score = 32.7 bits (71), Expect = 7.4
Identities = 16/51 (31%), Positives = 27/51 (52%)
Frame = +3
Query: 318 MDNDDDVQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYI 470
M +DD VQY I +K G+ L +++T E + + R + D+Y Y+
Sbjct: 685 MKHDDLVQYVINNVKDRGIPLVSDVKTAIEK--LLEKEYLEREDNDIYTYV 733
>UniRef50_Q67N12 Cluster: 3-isopropylmalate dehydrogenase; n=5;
Bacteria|Rep: 3-isopropylmalate dehydrogenase -
Symbiobacterium thermophilum
Length = 357
Score = 32.3 bits (70), Expect = 9.8
Identities = 23/79 (29%), Positives = 32/79 (40%), Gaps = 1/79 (1%)
Frame = +3
Query: 336 VQYAITTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT-RHK 512
V A ++ +G GLK T V S N LR E+D + + PGV T
Sbjct: 56 VYEAAAAMREHGYGLKAATITPEGRGDVGSPNAILRREIDGTVILRTGRPLPGVETIGGI 115
Query: 513 DIDVVIIRQNTEGEYAMLE 569
+ ++R TE Y E
Sbjct: 116 TAPIAVVRMATEDAYEAKE 134
>UniRef50_Q0JFH8 Cluster: Os04g0102600 protein; n=1; Oryza sativa
(japonica cultivar-group)|Rep: Os04g0102600 protein -
Oryza sativa subsp. japonica (Rice)
Length = 61
Score = 32.3 bits (70), Expect = 9.8
Identities = 18/54 (33%), Positives = 24/54 (44%)
Frame = -3
Query: 265 NMSRTYPMHSGPIPPPGSMVTA*RPPYCALGISFCFLITGVLCWTSKSDNVAGA 104
N++R+ P S PPP + A A S FL+ G W S+ AGA
Sbjct: 4 NINRSVPRPSLSFPPPSAAAAA----AAAASASSLFLLLGARAWLSRGSTAAGA 53
>UniRef50_O16397 Cluster: Serpentine receptor, class h protein 190;
n=1; Caenorhabditis elegans|Rep: Serpentine receptor,
class h protein 190 - Caenorhabditis elegans
Length = 333
Score = 32.3 bits (70), Expect = 9.8
Identities = 12/25 (48%), Positives = 17/25 (68%)
Frame = +3
Query: 234 PECMGYVRDIFKYIGAPIDFEVVDI 308
PE GY IFKY AP+++ VV++
Sbjct: 79 PELAGYPLGIFKYFNAPVEYYVVEV 103
>UniRef50_Q6BSN6 Cluster: Similar to Candida albicans CA2953; n=1;
Debaryomyces hansenii|Rep: Similar to Candida albicans
CA2953 - Debaryomyces hansenii (Yeast) (Torulaspora
hansenii)
Length = 904
Score = 32.3 bits (70), Expect = 9.8
Identities = 17/52 (32%), Positives = 28/52 (53%)
Frame = -2
Query: 374 HTVPLNGRYSILDIIIIVHRWVNVHHFEVNRSTDVFEYVANVSHALRTDTAS 219
H V N + + I H+++N H + T V EY+A+ +H LR DT++
Sbjct: 543 HIVAYNLNKKCIKVFISYHKYINFHLKNLVSYT-VEEYLASHNHVLRLDTSN 593
>UniRef50_Q2UB49 Cluster: Predicted protein; n=1; Aspergillus
oryzae|Rep: Predicted protein - Aspergillus oryzae
Length = 401
Score = 32.3 bits (70), Expect = 9.8
Identities = 17/40 (42%), Positives = 21/40 (52%)
Frame = -3
Query: 313 GSMSTTSKSIGAPMYLNMSRTYPMHSGPIPPPGSMVTA*R 194
G +T K I LN+ RT GP+PPP SM+ A R
Sbjct: 146 GHYTTEQKEIVIHQKLNVVRTAERERGPVPPPLSMLYAER 185
>UniRef50_A4R0Z8 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 881
Score = 32.3 bits (70), Expect = 9.8
Identities = 16/34 (47%), Positives = 22/34 (64%), Gaps = 3/34 (8%)
Frame = +3
Query: 117 LSDFDVQHKTPVIRKQKLIPK---AQYGGRHAVT 209
+SDFDVQH T V+ K++ P+ A GR+ VT
Sbjct: 153 ISDFDVQHTTHVVHKKRNTPRGLQALINGRYIVT 186
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 668,471,936
Number of Sequences: 1657284
Number of extensions: 14287889
Number of successful extensions: 42470
Number of sequences better than 10.0: 91
Number of HSP's better than 10.0 without gapping: 40761
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 42410
length of database: 575,637,011
effective HSP length: 97
effective length of database: 414,880,463
effective search space used: 46051731393
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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