BLASTX 2.2.12 [Aug-07-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= heS00271 (758 letters) Database: human 237,096 sequences; 76,859,062 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value X77244-1|CAA54460.1| 572|Homo sapiens malate dehydrogenase (oxa... 133 8e-31 U43944-1|AAC50613.1| 565|Homo sapiens cytosolic NADP(+)-depende... 133 8e-31 L34035-1|AAB01380.1| 572|Homo sapiens NADP-dependent malic enzy... 133 8e-31 BC025246-1|AAH25246.1| 572|Homo sapiens malic enzyme 1, NADP(+)... 133 8e-31 AL391416-2|CAH73129.1| 572|Homo sapiens malic enzyme 1, NADP(+)... 133 8e-31 AL136970-1|CAC19505.2| 572|Homo sapiens malic enzyme 1, NADP(+)... 133 8e-31 AL049699-1|CAI22634.1| 572|Homo sapiens malic enzyme 1, NADP(+)... 133 8e-31 AK223417-1|BAD97137.1| 572|Homo sapiens cytosolic malic enzyme ... 133 8e-31 X79440-1|CAA55956.1| 604|Homo sapiens malate dehydrogenase (oxa... 132 1e-30 BC022472-1|AAH22472.1| 604|Homo sapiens malic enzyme 3, NADP(+)... 132 1e-30 AY424278-1|AAR04784.1| 259|Homo sapiens mitochondrial NADP(+)-d... 132 1e-30 AK092181-1|BAC03822.1| 252|Homo sapiens protein ( Homo sapiens ... 132 1e-30 M55905-1|AAA36197.1| 584|Homo sapiens mitochondrial NAD(P)+ -de... 126 9e-29 BC000147-1|AAH00147.1| 479|Homo sapiens ME2 protein protein. 126 9e-29 BC017403-1|AAH17403.1| 233|Homo sapiens Unknown (protein for IM... 36 0.16 Y10931-1|CAA71861.1| 1142|Homo sapiens symplekin protein. 33 1.1 U49240-1|AAC50667.1| 1142|Homo sapiens symplekin protein. 33 1.1 BC006567-1|AAH06567.1| 1142|Homo sapiens SYMPK protein protein. 33 1.1 BC006536-1|AAH06536.1| 1142|Homo sapiens SYMPK protein protein. 33 1.1 AF057699-1|AAQ13438.1| 520|Homo sapiens EIF-2B-delta-like prote... 32 2.0 BC091502-1|AAH91502.1| 523|Homo sapiens eukaryotic translation ... 31 3.4 BC001870-1|AAH01870.1| 523|Homo sapiens eukaryotic translation ... 31 3.4 AJ011307-2|CAB57305.1| 542|Homo sapiens guanine nucleotide exch... 31 3.4 AJ011307-1|CAB57304.1| 522|Homo sapiens guanine nucleotide exch... 31 3.4 AJ011306-1|CAB57261.1| 543|Homo sapiens guanine nucleotide exch... 31 3.4 AJ011305-1|CAB57260.1| 522|Homo sapiens guanine nucleotide exch... 31 3.4 AF218009-1|AAG17251.1| 229|Homo sapiens unknown protein. 31 3.4 AF112207-1|AAF17195.1| 523|Homo sapiens translation initiation ... 31 3.4 AC074117-8|AAY14843.1| 522|Homo sapiens unknown protein. 31 3.4 >X77244-1|CAA54460.1| 572|Homo sapiens malate dehydrogenase (oxaloacetate decarboxylating) (NADP+) protein. Length = 572 Score = 133 bits (321), Expect = 8e-31 Identities = 59/84 (70%), Positives = 68/84 (80%) Frame = +3 Query: 3 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 182 H+ VL WPE ++AIVVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P +CLP+ Sbjct: 132 HIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPV 191 Query: 183 TIDVGTNTQSMLDDPLYIGLRQRR 254 +DVGT + +L DPLYIGLRQRR Sbjct: 192 ILDVGTENEELLKDPLYIGLRQRR 215 Score = 114 bits (275), Expect = 3e-25 Identities = 50/85 (58%), Positives = 61/85 (71%) Frame = +2 Query: 254 LRGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGNANAFRLLEKYRNKYCTFNDDIQXXXX 433 +RG +YD+ LDEFM AV +YG NCL+QFEDF N NAFRLL KYRN+YCTFNDDIQ Sbjct: 216 VRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTAS 275 Query: 434 XXXXXXXXSLRLTQKRLSDNVIVFQ 508 +LR+T+ +LSD I+FQ Sbjct: 276 VAVAGLLAALRITKNKLSDQTILFQ 300 Score = 44.0 bits (99), Expect = 6e-04 Identities = 19/31 (61%), Positives = 26/31 (83%) Frame = +1 Query: 547 VMAMKGEGTPEQEARCRIWMVDSKGLIVKNR 639 VMA++ EG P+++A +IW+VDSKGLIVK R Sbjct: 314 VMALEKEGLPKEKAIKKIWLVDSKGLIVKGR 344 Score = 35.9 bits (79), Expect = 0.16 Identities = 15/36 (41%), Positives = 23/36 (63%) Frame = +3 Query: 651 LNVHKERFAQDHAPVRTLAEVVEVARPSVLIGAAAI 758 L KE+FA +H ++ L +V+ +P+ LIG AAI Sbjct: 347 LTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAI 382 >U43944-1|AAC50613.1| 565|Homo sapiens cytosolic NADP(+)-dependent malic enzyme protein. Length = 565 Score = 133 bits (321), Expect = 8e-31 Identities = 59/84 (70%), Positives = 68/84 (80%) Frame = +3 Query: 3 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 182 H+ VL WPE ++AIVVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P +CLP+ Sbjct: 125 HIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPV 184 Query: 183 TIDVGTNTQSMLDDPLYIGLRQRR 254 +DVGT + +L DPLYIGLRQRR Sbjct: 185 ILDVGTENEELLKDPLYIGLRQRR 208 Score = 114 bits (275), Expect = 3e-25 Identities = 50/85 (58%), Positives = 61/85 (71%) Frame = +2 Query: 254 LRGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGNANAFRLLEKYRNKYCTFNDDIQXXXX 433 +RG +YD+ LDEFM AV +YG NCL+QFEDF N NAFRLL KYRN+YCTFNDDIQ Sbjct: 209 VRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTAS 268 Query: 434 XXXXXXXXSLRLTQKRLSDNVIVFQ 508 +LR+T+ +LSD I+FQ Sbjct: 269 VAVAGLLAALRITKNKLSDQTILFQ 293 Score = 44.0 bits (99), Expect = 6e-04 Identities = 19/31 (61%), Positives = 26/31 (83%) Frame = +1 Query: 547 VMAMKGEGTPEQEARCRIWMVDSKGLIVKNR 639 VMA++ EG P+++A +IW+VDSKGLIVK R Sbjct: 307 VMALEKEGLPKEKAIKKIWLVDSKGLIVKGR 337 Score = 35.9 bits (79), Expect = 0.16 Identities = 15/36 (41%), Positives = 23/36 (63%) Frame = +3 Query: 651 LNVHKERFAQDHAPVRTLAEVVEVARPSVLIGAAAI 758 L KE+FA +H ++ L +V+ +P+ LIG AAI Sbjct: 340 LTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAI 375 >L34035-1|AAB01380.1| 572|Homo sapiens NADP-dependent malic enzyme protein. Length = 572 Score = 133 bits (321), Expect = 8e-31 Identities = 59/84 (70%), Positives = 68/84 (80%) Frame = +3 Query: 3 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 182 H+ VL WPE ++AIVVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P +CLP+ Sbjct: 132 HIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPV 191 Query: 183 TIDVGTNTQSMLDDPLYIGLRQRR 254 +DVGT + +L DPLYIGLRQRR Sbjct: 192 ILDVGTENEELLKDPLYIGLRQRR 215 Score = 114 bits (275), Expect = 3e-25 Identities = 50/85 (58%), Positives = 61/85 (71%) Frame = +2 Query: 254 LRGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGNANAFRLLEKYRNKYCTFNDDIQXXXX 433 +RG +YD+ LDEFM AV +YG NCL+QFEDF N NAFRLL KYRN+YCTFNDDIQ Sbjct: 216 VRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTAS 275 Query: 434 XXXXXXXXSLRLTQKRLSDNVIVFQ 508 +LR+T+ +LSD I+FQ Sbjct: 276 VAVAGLLAALRITKNKLSDQTILFQ 300 Score = 44.0 bits (99), Expect = 6e-04 Identities = 19/31 (61%), Positives = 26/31 (83%) Frame = +1 Query: 547 VMAMKGEGTPEQEARCRIWMVDSKGLIVKNR 639 VMA++ EG P+++A +IW+VDSKGLIVK R Sbjct: 314 VMALEKEGLPKEKAIKKIWLVDSKGLIVKGR 344 Score = 35.9 bits (79), Expect = 0.16 Identities = 15/36 (41%), Positives = 23/36 (63%) Frame = +3 Query: 651 LNVHKERFAQDHAPVRTLAEVVEVARPSVLIGAAAI 758 L KE+FA +H ++ L +V+ +P+ LIG AAI Sbjct: 347 LTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAI 382 >BC025246-1|AAH25246.1| 572|Homo sapiens malic enzyme 1, NADP(+)-dependent, cytosolic protein. Length = 572 Score = 133 bits (321), Expect = 8e-31 Identities = 59/84 (70%), Positives = 68/84 (80%) Frame = +3 Query: 3 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 182 H+ VL WPE ++AIVVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P +CLP+ Sbjct: 132 HIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPV 191 Query: 183 TIDVGTNTQSMLDDPLYIGLRQRR 254 +DVGT + +L DPLYIGLRQRR Sbjct: 192 ILDVGTENEELLKDPLYIGLRQRR 215 Score = 114 bits (275), Expect = 3e-25 Identities = 50/85 (58%), Positives = 61/85 (71%) Frame = +2 Query: 254 LRGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGNANAFRLLEKYRNKYCTFNDDIQXXXX 433 +RG +YD+ LDEFM AV +YG NCL+QFEDF N NAFRLL KYRN+YCTFNDDIQ Sbjct: 216 VRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTAS 275 Query: 434 XXXXXXXXSLRLTQKRLSDNVIVFQ 508 +LR+T+ +LSD I+FQ Sbjct: 276 VAVAGLLAALRITKNKLSDQTILFQ 300 Score = 44.0 bits (99), Expect = 6e-04 Identities = 19/31 (61%), Positives = 26/31 (83%) Frame = +1 Query: 547 VMAMKGEGTPEQEARCRIWMVDSKGLIVKNR 639 VMA++ EG P+++A +IW+VDSKGLIVK R Sbjct: 314 VMALEKEGLPKEKAIKKIWLVDSKGLIVKGR 344 Score = 35.9 bits (79), Expect = 0.16 Identities = 15/36 (41%), Positives = 23/36 (63%) Frame = +3 Query: 651 LNVHKERFAQDHAPVRTLAEVVEVARPSVLIGAAAI 758 L KE+FA +H ++ L +V+ +P+ LIG AAI Sbjct: 347 LTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAI 382 >AL391416-2|CAH73129.1| 572|Homo sapiens malic enzyme 1, NADP(+)-dependent, cytosolic protein. Length = 572 Score = 133 bits (321), Expect = 8e-31 Identities = 59/84 (70%), Positives = 68/84 (80%) Frame = +3 Query: 3 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 182 H+ VL WPE ++AIVVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P +CLP+ Sbjct: 132 HIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPV 191 Query: 183 TIDVGTNTQSMLDDPLYIGLRQRR 254 +DVGT + +L DPLYIGLRQRR Sbjct: 192 ILDVGTENEELLKDPLYIGLRQRR 215 Score = 114 bits (275), Expect = 3e-25 Identities = 50/85 (58%), Positives = 61/85 (71%) Frame = +2 Query: 254 LRGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGNANAFRLLEKYRNKYCTFNDDIQXXXX 433 +RG +YD+ LDEFM AV +YG NCL+QFEDF N NAFRLL KYRN+YCTFNDDIQ Sbjct: 216 VRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTAS 275 Query: 434 XXXXXXXXSLRLTQKRLSDNVIVFQ 508 +LR+T+ +LSD I+FQ Sbjct: 276 VAVAGLLAALRITKNKLSDQTILFQ 300 Score = 44.0 bits (99), Expect = 6e-04 Identities = 19/31 (61%), Positives = 26/31 (83%) Frame = +1 Query: 547 VMAMKGEGTPEQEARCRIWMVDSKGLIVKNR 639 VMA++ EG P+++A +IW+VDSKGLIVK R Sbjct: 314 VMALEKEGLPKEKAIKKIWLVDSKGLIVKGR 344 Score = 35.9 bits (79), Expect = 0.16 Identities = 15/36 (41%), Positives = 23/36 (63%) Frame = +3 Query: 651 LNVHKERFAQDHAPVRTLAEVVEVARPSVLIGAAAI 758 L KE+FA +H ++ L +V+ +P+ LIG AAI Sbjct: 347 LTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAI 382 >AL136970-1|CAC19505.2| 572|Homo sapiens malic enzyme 1, NADP(+)-dependent, cytosolic protein. Length = 572 Score = 133 bits (321), Expect = 8e-31 Identities = 59/84 (70%), Positives = 68/84 (80%) Frame = +3 Query: 3 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 182 H+ VL WPE ++AIVVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P +CLP+ Sbjct: 132 HIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPV 191 Query: 183 TIDVGTNTQSMLDDPLYIGLRQRR 254 +DVGT + +L DPLYIGLRQRR Sbjct: 192 ILDVGTENEELLKDPLYIGLRQRR 215 Score = 114 bits (275), Expect = 3e-25 Identities = 50/85 (58%), Positives = 61/85 (71%) Frame = +2 Query: 254 LRGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGNANAFRLLEKYRNKYCTFNDDIQXXXX 433 +RG +YD+ LDEFM AV +YG NCL+QFEDF N NAFRLL KYRN+YCTFNDDIQ Sbjct: 216 VRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTAS 275 Query: 434 XXXXXXXXSLRLTQKRLSDNVIVFQ 508 +LR+T+ +LSD I+FQ Sbjct: 276 VAVAGLLAALRITKNKLSDQTILFQ 300 Score = 44.0 bits (99), Expect = 6e-04 Identities = 19/31 (61%), Positives = 26/31 (83%) Frame = +1 Query: 547 VMAMKGEGTPEQEARCRIWMVDSKGLIVKNR 639 VMA++ EG P+++A +IW+VDSKGLIVK R Sbjct: 314 VMALEKEGLPKEKAIKKIWLVDSKGLIVKGR 344 Score = 35.9 bits (79), Expect = 0.16 Identities = 15/36 (41%), Positives = 23/36 (63%) Frame = +3 Query: 651 LNVHKERFAQDHAPVRTLAEVVEVARPSVLIGAAAI 758 L KE+FA +H ++ L +V+ +P+ LIG AAI Sbjct: 347 LTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAI 382 >AL049699-1|CAI22634.1| 572|Homo sapiens malic enzyme 1, NADP(+)-dependent, cytosolic protein. Length = 572 Score = 133 bits (321), Expect = 8e-31 Identities = 59/84 (70%), Positives = 68/84 (80%) Frame = +3 Query: 3 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 182 H+ VL WPE ++AIVVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P +CLP+ Sbjct: 132 HIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPV 191 Query: 183 TIDVGTNTQSMLDDPLYIGLRQRR 254 +DVGT + +L DPLYIGLRQRR Sbjct: 192 ILDVGTENEELLKDPLYIGLRQRR 215 Score = 114 bits (275), Expect = 3e-25 Identities = 50/85 (58%), Positives = 61/85 (71%) Frame = +2 Query: 254 LRGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGNANAFRLLEKYRNKYCTFNDDIQXXXX 433 +RG +YD+ LDEFM AV +YG NCL+QFEDF N NAFRLL KYRN+YCTFNDDIQ Sbjct: 216 VRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTAS 275 Query: 434 XXXXXXXXSLRLTQKRLSDNVIVFQ 508 +LR+T+ +LSD I+FQ Sbjct: 276 VAVAGLLAALRITKNKLSDQTILFQ 300 Score = 44.0 bits (99), Expect = 6e-04 Identities = 19/31 (61%), Positives = 26/31 (83%) Frame = +1 Query: 547 VMAMKGEGTPEQEARCRIWMVDSKGLIVKNR 639 VMA++ EG P+++A +IW+VDSKGLIVK R Sbjct: 314 VMALEKEGLPKEKAIKKIWLVDSKGLIVKGR 344 Score = 35.9 bits (79), Expect = 0.16 Identities = 15/36 (41%), Positives = 23/36 (63%) Frame = +3 Query: 651 LNVHKERFAQDHAPVRTLAEVVEVARPSVLIGAAAI 758 L KE+FA +H ++ L +V+ +P+ LIG AAI Sbjct: 347 LTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAI 382 >AK223417-1|BAD97137.1| 572|Homo sapiens cytosolic malic enzyme 1 variant protein. Length = 572 Score = 133 bits (321), Expect = 8e-31 Identities = 59/84 (70%), Positives = 68/84 (80%) Frame = +3 Query: 3 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 182 H+ VL WPE ++AIVVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P +CLP+ Sbjct: 132 HIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPV 191 Query: 183 TIDVGTNTQSMLDDPLYIGLRQRR 254 +DVGT + +L DPLYIGLRQRR Sbjct: 192 ILDVGTENEELLKDPLYIGLRQRR 215 Score = 111 bits (267), Expect = 3e-24 Identities = 49/85 (57%), Positives = 60/85 (70%) Frame = +2 Query: 254 LRGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGNANAFRLLEKYRNKYCTFNDDIQXXXX 433 +RG +YD+ LDEFM AV +YG NCL+QFEDF N NAFRLL KYRN+YCT NDDIQ Sbjct: 216 VRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTSNDDIQGTAS 275 Query: 434 XXXXXXXXSLRLTQKRLSDNVIVFQ 508 +LR+T+ +LSD I+FQ Sbjct: 276 VAVAGLLAALRITKNKLSDQTILFQ 300 Score = 44.0 bits (99), Expect = 6e-04 Identities = 19/31 (61%), Positives = 26/31 (83%) Frame = +1 Query: 547 VMAMKGEGTPEQEARCRIWMVDSKGLIVKNR 639 VMA++ EG P+++A +IW+VDSKGLIVK R Sbjct: 314 VMALEKEGLPKEKAIKKIWLVDSKGLIVKGR 344 Score = 35.9 bits (79), Expect = 0.16 Identities = 15/36 (41%), Positives = 23/36 (63%) Frame = +3 Query: 651 LNVHKERFAQDHAPVRTLAEVVEVARPSVLIGAAAI 758 L KE+FA +H ++ L +V+ +P+ LIG AAI Sbjct: 347 LTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAI 382 >X79440-1|CAA55956.1| 604|Homo sapiens malate dehydrogenase (oxaloacetate decarboxylating) (NADP+) protein. Length = 604 Score = 132 bits (320), Expect = 1e-30 Identities = 56/84 (66%), Positives = 70/84 (83%) Frame = +3 Query: 3 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 182 H+ +L +WPE +++A+VVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P QCLP+ Sbjct: 167 HLATMLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPV 226 Query: 183 TIDVGTNTQSMLDDPLYIGLRQRR 254 +DVGTN + +L DPLYIGL+ +R Sbjct: 227 LLDVGTNNEELLRDPLYIGLKHQR 250 Score = 110 bits (265), Expect = 5e-24 Identities = 50/85 (58%), Positives = 61/85 (71%) Frame = +2 Query: 254 LRGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGNANAFRLLEKYRNKYCTFNDDIQXXXX 433 + G YD+LLDEFM+AV ++G NCL+QFEDF NANAFRLL KYRNKYC FNDDIQ Sbjct: 251 VHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTAS 310 Query: 434 XXXXXXXXSLRLTQKRLSDNVIVFQ 508 +LR+T +LS++V VFQ Sbjct: 311 VAVAGILAALRITNNKLSNHVFVFQ 335 Score = 46.8 bits (106), Expect = 8e-05 Identities = 21/31 (67%), Positives = 25/31 (80%) Frame = +1 Query: 547 VMAMKGEGTPEQEARCRIWMVDSKGLIVKNR 639 VMA++ EG P+ EA +IWMVDSKGLIVK R Sbjct: 349 VMALEKEGVPKAEATRKIWMVDSKGLIVKGR 379 Score = 44.0 bits (99), Expect = 6e-04 Identities = 20/36 (55%), Positives = 25/36 (69%) Frame = +3 Query: 651 LNVHKERFAQDHAPVRTLAEVVEVARPSVLIGAAAI 758 LN KE FAQDH V +L EVV + +P+ +IG AAI Sbjct: 382 LNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAI 417 >BC022472-1|AAH22472.1| 604|Homo sapiens malic enzyme 3, NADP(+)-dependent, mitochondrial protein. Length = 604 Score = 132 bits (320), Expect = 1e-30 Identities = 56/84 (66%), Positives = 70/84 (83%) Frame = +3 Query: 3 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 182 H+ +L +WPE +++A+VVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P QCLP+ Sbjct: 167 HLATMLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPV 226 Query: 183 TIDVGTNTQSMLDDPLYIGLRQRR 254 +DVGTN + +L DPLYIGL+ +R Sbjct: 227 LLDVGTNNEELLRDPLYIGLKHQR 250 Score = 110 bits (265), Expect = 5e-24 Identities = 50/85 (58%), Positives = 61/85 (71%) Frame = +2 Query: 254 LRGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGNANAFRLLEKYRNKYCTFNDDIQXXXX 433 + G YD+LLDEFM+AV ++G NCL+QFEDF NANAFRLL KYRNKYC FNDDIQ Sbjct: 251 VHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTAS 310 Query: 434 XXXXXXXXSLRLTQKRLSDNVIVFQ 508 +LR+T +LS++V VFQ Sbjct: 311 VAVAGILAALRITNNKLSNHVFVFQ 335 Score = 46.8 bits (106), Expect = 8e-05 Identities = 21/31 (67%), Positives = 25/31 (80%) Frame = +1 Query: 547 VMAMKGEGTPEQEARCRIWMVDSKGLIVKNR 639 VMA++ EG P+ EA +IWMVDSKGLIVK R Sbjct: 349 VMALEKEGVPKAEATRKIWMVDSKGLIVKGR 379 Score = 44.0 bits (99), Expect = 6e-04 Identities = 20/36 (55%), Positives = 25/36 (69%) Frame = +3 Query: 651 LNVHKERFAQDHAPVRTLAEVVEVARPSVLIGAAAI 758 LN KE FAQDH V +L EVV + +P+ +IG AAI Sbjct: 382 LNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAI 417 >AY424278-1|AAR04784.1| 259|Homo sapiens mitochondrial NADP(+)-dependent malic enzyme 3 protein. Length = 259 Score = 132 bits (320), Expect = 1e-30 Identities = 56/84 (66%), Positives = 70/84 (83%) Frame = +3 Query: 3 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 182 H+ +L +WPE +++A+VVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P QCLP+ Sbjct: 105 HLATMLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPV 164 Query: 183 TIDVGTNTQSMLDDPLYIGLRQRR 254 +DVGTN + +L DPLYIGL+ +R Sbjct: 165 LLDVGTNNEELLRDPLYIGLKHQR 188 Score = 96.3 bits (229), Expect = 1e-19 Identities = 41/56 (73%), Positives = 47/56 (83%) Frame = +2 Query: 254 LRGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGNANAFRLLEKYRNKYCTFNDDIQ 421 + G YD+LLDEFM+AV ++G NCL+QFEDF NANAFRLL KYRNKYC FNDDIQ Sbjct: 189 VHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQ 244 >AK092181-1|BAC03822.1| 252|Homo sapiens protein ( Homo sapiens cDNA FLJ34862 fis, clone NT2NE2013547, highly similar to NADP-DEPENDENT MALIC ENZYME, MITOCHONDRIAL PRECURSOR (EC 1.1.1.40). ). Length = 252 Score = 132 bits (320), Expect = 1e-30 Identities = 56/84 (66%), Positives = 70/84 (83%) Frame = +3 Query: 3 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 182 H+ +L +WPE +++A+VVTDGERILGLGDLG GMGIPVGKLALYTA GG+ P QCLP+ Sbjct: 105 HLATMLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPV 164 Query: 183 TIDVGTNTQSMLDDPLYIGLRQRR 254 +DVGTN + +L DPLYIGL+ +R Sbjct: 165 LLDVGTNNEELLRDPLYIGLKHQR 188 Score = 96.3 bits (229), Expect = 1e-19 Identities = 41/56 (73%), Positives = 47/56 (83%) Frame = +2 Query: 254 LRGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGNANAFRLLEKYRNKYCTFNDDIQ 421 + G YD+LLDEFM+AV ++G NCL+QFEDF NANAFRLL KYRNKYC FNDDIQ Sbjct: 189 VHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQ 244 >M55905-1|AAA36197.1| 584|Homo sapiens mitochondrial NAD(P)+ -dependent malic enzyme protein. Length = 584 Score = 126 bits (304), Expect = 9e-29 Identities = 55/84 (65%), Positives = 67/84 (79%) Frame = +3 Query: 3 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 182 HV ++ NWPE V+A+VVTDGERILGLGDLG GMGIPVGKL LYTA GI+P +CLP+ Sbjct: 142 HVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPV 201 Query: 183 TIDVGTNTQSMLDDPLYIGLRQRR 254 IDVGT+ ++L DP Y+GL Q+R Sbjct: 202 CIDVGTDNIALLKDPFYMGLYQKR 225 Score = 97.5 bits (232), Expect = 5e-20 Identities = 43/83 (51%), Positives = 56/83 (67%) Frame = +2 Query: 257 RGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGNANAFRLLEKYRNKYCTFNDDIQXXXXX 436 R YD+L+DEFM+A+ RYG+N L+QFEDFGN NAFR L KYR KYCTFNDDIQ Sbjct: 227 RTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAV 286 Query: 437 XXXXXXXSLRLTQKRLSDNVIVF 505 + ++ K +S++ I+F Sbjct: 287 ALAGLLAAQKVISKPISEHKILF 309 Score = 37.5 bits (83), Expect = 0.052 Identities = 17/31 (54%), Positives = 21/31 (67%) Frame = +1 Query: 547 VMAMKGEGTPEQEARCRIWMVDSKGLIVKNR 639 VM+M G EQEA+ +IWM D GL+VK R Sbjct: 324 VMSMVENGLSEQEAQKKIWMFDKYGLLVKGR 354 >BC000147-1|AAH00147.1| 479|Homo sapiens ME2 protein protein. Length = 479 Score = 126 bits (304), Expect = 9e-29 Identities = 55/84 (65%), Positives = 67/84 (79%) Frame = +3 Query: 3 HVYDVLKNWPETDVRAIVVTDGERILGLGDLGACGMGIPVGKLALYTALGGIKPHQCLPI 182 HV ++ NWPE V+A+VVTDGERILGLGDLG GMGIPVGKL LYTA GI+P +CLP+ Sbjct: 142 HVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPV 201 Query: 183 TIDVGTNTQSMLDDPLYIGLRQRR 254 IDVGT+ ++L DP Y+GL Q+R Sbjct: 202 CIDVGTDNIALLKDPFYMGLYQKR 225 Score = 97.5 bits (232), Expect = 5e-20 Identities = 43/83 (51%), Positives = 56/83 (67%) Frame = +2 Query: 257 RGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGNANAFRLLEKYRNKYCTFNDDIQXXXXX 436 R YD+L+DEFM+A+ RYG+N L+QFEDFGN NAFR L KYR KYCTFNDDIQ Sbjct: 227 RTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAV 286 Query: 437 XXXXXXXSLRLTQKRLSDNVIVF 505 + ++ K +S++ I+F Sbjct: 287 ALAGLLAAQKVISKPISEHKILF 309 Score = 37.5 bits (83), Expect = 0.052 Identities = 17/31 (54%), Positives = 21/31 (67%) Frame = +1 Query: 547 VMAMKGEGTPEQEARCRIWMVDSKGLIVKNR 639 VM+M G EQEA+ +IWM D GL+VK R Sbjct: 324 VMSMVENGLSEQEAQKKIWMFDKYGLLVKGR 354 >BC017403-1|AAH17403.1| 233|Homo sapiens Unknown (protein for IMAGE:4290619) protein. Length = 233 Score = 35.9 bits (79), Expect = 0.16 Identities = 15/36 (41%), Positives = 23/36 (63%) Frame = +3 Query: 651 LNVHKERFAQDHAPVRTLAEVVEVARPSVLIGAAAI 758 L KE+FA +H ++ L +V+ +P+ LIG AAI Sbjct: 8 LTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAI 43 >Y10931-1|CAA71861.1| 1142|Homo sapiens symplekin protein. Length = 1142 Score = 33.1 bits (72), Expect = 1.1 Identities = 16/32 (50%), Positives = 19/32 (59%) Frame = +3 Query: 600 LDGGLEGPHRQEQTGGGLNVHKERFAQDHAPV 695 LD LEGP +E GGL + +ER Q APV Sbjct: 1087 LDSSLEGPLPKETAAGGLTLKEERSPQTLAPV 1118 >U49240-1|AAC50667.1| 1142|Homo sapiens symplekin protein. Length = 1142 Score = 33.1 bits (72), Expect = 1.1 Identities = 16/32 (50%), Positives = 19/32 (59%) Frame = +3 Query: 600 LDGGLEGPHRQEQTGGGLNVHKERFAQDHAPV 695 LD LEGP +E GGL + +ER Q APV Sbjct: 1087 LDSSLEGPLPKETAAGGLTLKEERSPQTLAPV 1118 >BC006567-1|AAH06567.1| 1142|Homo sapiens SYMPK protein protein. Length = 1142 Score = 33.1 bits (72), Expect = 1.1 Identities = 16/32 (50%), Positives = 19/32 (59%) Frame = +3 Query: 600 LDGGLEGPHRQEQTGGGLNVHKERFAQDHAPV 695 LD LEGP +E GGL + +ER Q APV Sbjct: 1087 LDSSLEGPLPKETAAGGLTLKEERSPQTLAPV 1118 >BC006536-1|AAH06536.1| 1142|Homo sapiens SYMPK protein protein. Length = 1142 Score = 33.1 bits (72), Expect = 1.1 Identities = 16/32 (50%), Positives = 19/32 (59%) Frame = +3 Query: 600 LDGGLEGPHRQEQTGGGLNVHKERFAQDHAPV 695 LD LEGP +E GGL + +ER Q APV Sbjct: 1087 LDSSLEGPLPKETAAGGLTLKEERSPQTLAPV 1118 >AF057699-1|AAQ13438.1| 520|Homo sapiens EIF-2B-delta-like protein protein. Length = 520 Score = 32.3 bits (70), Expect = 2.0 Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 5/104 (4%) Frame = +2 Query: 89 RFGRVRDGHPCGQTRALHRARRH--QASSVSTHHYRRGYEH--PVDAGRPAVHRAPAAAL 256 + G R+ P G+++A RA R Q + + R+G + P A P+ Sbjct: 80 QLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAEETPSGVK 139 Query: 257 RGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGN-ANAFRLLEKY 385 R P+Y ++ D +R +V++ + + +D+G+ + F L +Y Sbjct: 140 RLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQY 183 >BC091502-1|AAH91502.1| 523|Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa protein. Length = 523 Score = 31.5 bits (68), Expect = 3.4 Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 5/104 (4%) Frame = +2 Query: 89 RFGRVRDGHPCGQTRALHRARRH--QASSVSTHHYRRGYEH--PVDAGRPAVHRAPAAAL 256 + G R+ P G+++A RA R Q + + R+G + P A P+ Sbjct: 83 QLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVK 142 Query: 257 RGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGN-ANAFRLLEKY 385 R P+Y ++ D +R +V++ + + +D+G+ + F L +Y Sbjct: 143 RLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQY 186 >BC001870-1|AAH01870.1| 523|Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa protein. Length = 523 Score = 31.5 bits (68), Expect = 3.4 Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 5/104 (4%) Frame = +2 Query: 89 RFGRVRDGHPCGQTRALHRARRH--QASSVSTHHYRRGYEH--PVDAGRPAVHRAPAAAL 256 + G R+ P G+++A RA R Q + + R+G + P A P+ Sbjct: 83 QLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVK 142 Query: 257 RGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGN-ANAFRLLEKY 385 R P+Y ++ D +R +V++ + + +D+G+ + F L +Y Sbjct: 143 RLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQY 186 >AJ011307-2|CAB57305.1| 542|Homo sapiens guanine nucleotide exchange factor protein. Length = 542 Score = 31.5 bits (68), Expect = 3.4 Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 5/104 (4%) Frame = +2 Query: 89 RFGRVRDGHPCGQTRALHRARRH--QASSVSTHHYRRGYEH--PVDAGRPAVHRAPAAAL 256 + G R+ P G+++A RA R Q + + R+G + P A P+ Sbjct: 102 QLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVK 161 Query: 257 RGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGN-ANAFRLLEKY 385 R P+Y ++ D +R +V++ + + +D+G+ + F L +Y Sbjct: 162 RLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQY 205 >AJ011307-1|CAB57304.1| 522|Homo sapiens guanine nucleotide exchange factor protein. Length = 522 Score = 31.5 bits (68), Expect = 3.4 Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 5/104 (4%) Frame = +2 Query: 89 RFGRVRDGHPCGQTRALHRARRH--QASSVSTHHYRRGYEH--PVDAGRPAVHRAPAAAL 256 + G R+ P G+++A RA R Q + + R+G + P A P+ Sbjct: 82 QLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVK 141 Query: 257 RGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGN-ANAFRLLEKY 385 R P+Y ++ D +R +V++ + + +D+G+ + F L +Y Sbjct: 142 RLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQY 185 >AJ011306-1|CAB57261.1| 543|Homo sapiens guanine nucleotide exchange factor (long isoform) protein. Length = 543 Score = 31.5 bits (68), Expect = 3.4 Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 5/104 (4%) Frame = +2 Query: 89 RFGRVRDGHPCGQTRALHRARRH--QASSVSTHHYRRGYEH--PVDAGRPAVHRAPAAAL 256 + G R+ P G+++A RA R Q + + R+G + P A P+ Sbjct: 103 QLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVK 162 Query: 257 RGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGN-ANAFRLLEKY 385 R P+Y ++ D +R +V++ + + +D+G+ + F L +Y Sbjct: 163 RLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQY 206 >AJ011305-1|CAB57260.1| 522|Homo sapiens guanine nucleotide exchange factor, delta subunit protein. Length = 522 Score = 31.5 bits (68), Expect = 3.4 Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 5/104 (4%) Frame = +2 Query: 89 RFGRVRDGHPCGQTRALHRARRH--QASSVSTHHYRRGYEH--PVDAGRPAVHRAPAAAL 256 + G R+ P G+++A RA R Q + + R+G + P A P+ Sbjct: 82 QLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVK 141 Query: 257 RGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGN-ANAFRLLEKY 385 R P+Y ++ D +R +V++ + + +D+G+ + F L +Y Sbjct: 142 RLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQY 185 >AF218009-1|AAG17251.1| 229|Homo sapiens unknown protein. Length = 229 Score = 31.5 bits (68), Expect = 3.4 Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 5/104 (4%) Frame = +2 Query: 89 RFGRVRDGHPCGQTRALHRARRH--QASSVSTHHYRRGYEH--PVDAGRPAVHRAPAAAL 256 + G R+ P G+++A RA R Q + + R+G + P A P+ Sbjct: 68 QLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVK 127 Query: 257 RGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGN-ANAFRLLEKY 385 R P+Y ++ D +R +V++ + + +D+G+ + F L +Y Sbjct: 128 RLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQY 171 >AF112207-1|AAF17195.1| 523|Homo sapiens translation initiation factor eIF-2b delta subunit protein. Length = 523 Score = 31.5 bits (68), Expect = 3.4 Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 5/104 (4%) Frame = +2 Query: 89 RFGRVRDGHPCGQTRALHRARRH--QASSVSTHHYRRGYEH--PVDAGRPAVHRAPAAAL 256 + G R+ P G+++A RA R Q + + R+G + P A P+ Sbjct: 83 QLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVK 142 Query: 257 RGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGN-ANAFRLLEKY 385 R P+Y ++ D +R +V++ + + +D+G+ + F L +Y Sbjct: 143 RLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQY 186 >AC074117-8|AAY14843.1| 522|Homo sapiens unknown protein. Length = 522 Score = 31.5 bits (68), Expect = 3.4 Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 5/104 (4%) Frame = +2 Query: 89 RFGRVRDGHPCGQTRALHRARRH--QASSVSTHHYRRGYEH--PVDAGRPAVHRAPAAAL 256 + G R+ P G+++A RA R Q + + R+G + P A P+ Sbjct: 82 QLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVK 141 Query: 257 RGPDYDELLDEFMRAVVRRYGQNCLVQFEDFGN-ANAFRLLEKY 385 R P+Y ++ D +R +V++ + + +D+G+ + F L +Y Sbjct: 142 RLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQY 185 Database: human Posted date: Oct 23, 2007 1:18 PM Number of letters in database: 76,859,062 Number of sequences in database: 237,096 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.279 0.0580 0.190 Matrix: BLOSUM62 Gap Penalties: Existence: 9, Extension: 2 Number of Hits to DB: 102,182,181 Number of Sequences: 237096 Number of extensions: 2126274 Number of successful extensions: 6152 Number of sequences better than 10.0: 29 Number of HSP's better than 10.0 without gapping: 5698 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6150 length of database: 76,859,062 effective HSP length: 88 effective length of database: 55,994,614 effective search space used: 9183116696 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 37 (14.9 bits) X3: 62 (25.0 bits) S1: 41 (21.7 bits)
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