Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fprWP02_F_E10
(653 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q7NWA9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=7... 126 5e-28
UniRef50_A7UBP6 Cluster: Putative 3-hydroxyisobutyrate dehydroge... 123 4e-27
UniRef50_A0JUJ6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 122 8e-27
UniRef50_Q54CX6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3... 119 5e-26
UniRef50_A7JGH8 Cluster: Predicted protein; n=1; Francisella tul... 117 2e-25
UniRef50_UPI0000D56743 Cluster: PREDICTED: similar to 3-hydroxyi... 115 9e-25
UniRef50_P28811 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=7... 110 3e-23
UniRef50_Q4FMJ3 Cluster: 6-phosphogluconate dehydrogenase; n=2; ... 108 1e-22
UniRef50_A3I4V2 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 108 1e-22
UniRef50_Q0SBQ9 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 107 3e-22
UniRef50_A0UF54 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 107 3e-22
UniRef50_UPI00015B4162 Cluster: PREDICTED: similar to MGC108315 ... 105 7e-22
UniRef50_Q399N0 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=7... 105 1e-21
UniRef50_A1QPH6 Cluster: 3-hydroxyisobutyrate dehydrogenase mmsB... 105 1e-21
UniRef50_P63936 Cluster: Probable 3-hydroxyisobutyrate dehydroge... 105 1e-21
UniRef50_P31937 Cluster: 3-hydroxyisobutyrate dehydrogenase, mit... 104 2e-21
UniRef50_A0QSJ0 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3... 101 1e-20
UniRef50_Q8ES28 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 101 2e-20
UniRef50_Q0K0E2 Cluster: 3-Hydroxyisobutyrate dehydrogenase; n=1... 101 2e-20
UniRef50_O34948 Cluster: Uncharacterized oxidoreductase ykwC; n=... 100 3e-20
UniRef50_Q9K9L1 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 100 3e-20
UniRef50_Q41DK0 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 100 3e-20
UniRef50_Q9V8M5 Cluster: Probable 3-hydroxyisobutyrate dehydroge... 99 5e-20
UniRef50_Q83D20 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=9... 100 6e-20
UniRef50_Q9A8J9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 99 1e-19
UniRef50_Q1AVA4 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 98 1e-19
UniRef50_A5V0D4 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 97 2e-19
UniRef50_A1SIN3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 97 2e-19
UniRef50_A6LT11 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 96 6e-19
UniRef50_Q22B54 Cluster: 3-hydroxyisobutyrate dehydrogenase fami... 96 7e-19
UniRef50_Q11FC5 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 95 1e-18
UniRef50_A3RRS1 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 95 1e-18
UniRef50_Q930C6 Cluster: Probable; n=8; Alphaproteobacteria|Rep:... 95 1e-18
UniRef50_A2SP40 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 95 1e-18
UniRef50_Q8KL12 Cluster: Probable 6-phosphogluconate dehydrogena... 95 2e-18
UniRef50_Q1V2R0 Cluster: MmsB-like protein; n=2; Candidatus Pela... 95 2e-18
UniRef50_Q55702 Cluster: Uncharacterized oxidoreductase slr0229;... 94 2e-18
UniRef50_A3SJ77 Cluster: Probable oxidoreductase; n=1; Roseovari... 94 3e-18
UniRef50_A6NVP0 Cluster: Putative uncharacterized protein; n=1; ... 93 4e-18
UniRef50_A4IN46 Cluster: 3-hydroxyisobutyrate dehydrogenase-like... 93 5e-18
UniRef50_Q92D17 Cluster: Lin1004 protein; n=10; Bacilli|Rep: Lin... 93 7e-18
UniRef50_A6P2M7 Cluster: Putative uncharacterized protein; n=2; ... 92 9e-18
UniRef50_Q97XZ7 Cluster: Oxidoreductase; n=6; Thermoprotei|Rep: ... 92 1e-17
UniRef50_Q5L168 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 90 4e-17
UniRef50_Q4ZQL5 Cluster: 3-hydroxyisobutyrate dehydrogenase prec... 90 5e-17
UniRef50_Q1QWQ5 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 90 5e-17
UniRef50_A6GTB5 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 90 5e-17
UniRef50_Q0QLF5 Cluster: 2-hydroxymethyl glutarate dehydrogenase... 89 7e-17
UniRef50_Q58PL4 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 89 9e-17
UniRef50_Q01ZG6 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 89 9e-17
UniRef50_Q183P5 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 89 1e-16
UniRef50_Q1QWU9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 88 2e-16
UniRef50_A6SW62 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 88 2e-16
UniRef50_Q03UI4 Cluster: 3-hydroxyisobutyrate dehydrogenase rela... 88 2e-16
UniRef50_P0ABQ3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 87 3e-16
UniRef50_Q9SUC0 Cluster: Probable 3-hydroxyisobutyrate dehydroge... 87 3e-16
UniRef50_A0K0Z6 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 85 1e-15
UniRef50_Q8UBW3 Cluster: Oxidoredutase; n=1; Agrobacterium tumef... 85 2e-15
UniRef50_A1UP64 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 84 3e-15
UniRef50_Q5WBB8 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 83 4e-15
UniRef50_Q9L7S0 Cluster: Uncharacterized oxidoreductase yihU; n=... 83 6e-15
UniRef50_Q89UN2 Cluster: Bll1384 protein; n=9; Bacteria|Rep: Bll... 83 7e-15
UniRef50_Q2JEV5 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 83 7e-15
UniRef50_A0GVR3 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 82 1e-14
UniRef50_Q89R44 Cluster: Oxidoreductase; n=23; Bacteria|Rep: Oxi... 81 2e-14
UniRef50_Q1YHQ4 Cluster: Putative 2-hydroxy-3-oxopropionate redu... 81 2e-14
UniRef50_Q0S5S3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 81 2e-14
UniRef50_A6SUL3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 81 2e-14
UniRef50_A0LMG6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=9... 81 2e-14
UniRef50_Q67QX0 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 81 3e-14
UniRef50_Q12CU4 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 81 3e-14
UniRef50_A0N0V2 Cluster: BtdhL; n=1; Azoarcus anaerobius|Rep: Bt... 81 3e-14
UniRef50_Q4Q7T9 Cluster: 2-hydroxy-3-oxopropionate reductase, pu... 81 3e-14
UniRef50_Q7WG50 Cluster: Probable oxidoreductase; n=1; Bordetell... 80 5e-14
UniRef50_A5VEA3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 80 5e-14
UniRef50_A3JU55 Cluster: Predicted dehydrogenase, with NAD(P)-bi... 79 7e-14
UniRef50_A0G5G5 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 79 9e-14
UniRef50_A5USN9 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 78 2e-13
UniRef50_Q8TT25 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 78 2e-13
UniRef50_A0QUD5 Cluster: 3-hydroxyisobutyrate dehydrogenase fami... 78 2e-13
UniRef50_Q89HA0 Cluster: Oxidoreductase; n=1; Bradyrhizobium jap... 77 3e-13
UniRef50_Q1B326 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 77 3e-13
UniRef50_A3WAC4 Cluster: Dehydrogenase; n=4; Bacteria|Rep: Dehyd... 77 3e-13
UniRef50_A3VLN6 Cluster: Oxidoreductase; n=1; Rhodobacterales ba... 77 3e-13
UniRef50_A7DSF1 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 77 3e-13
UniRef50_A1R2J4 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 77 4e-13
UniRef50_A0LTQ8 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 77 5e-13
UniRef50_Q4KH51 Cluster: 3-hydroxyisobutyrate dehydrogenase fami... 76 6e-13
UniRef50_A7PEG7 Cluster: Chromosome chr11 scaffold_13, whole gen... 76 6e-13
UniRef50_A2U9T6 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 76 9e-13
UniRef50_Q4WV01 Cluster: Oxidoreductase, acting on the CH-OH gro... 76 9e-13
UniRef50_Q3DYV4 Cluster: NADP oxidoreductase, coenzyme F420-depe... 75 1e-12
UniRef50_Q84H84 Cluster: Putative oxidoreductase; n=1; Arthrobac... 75 2e-12
UniRef50_Q18X68 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 74 3e-12
UniRef50_A1B741 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3... 74 3e-12
UniRef50_Q55JR1 Cluster: Putative uncharacterized protein; n=2; ... 74 3e-12
UniRef50_Q73P00 Cluster: 3-hydroxyacid dehydrogenase family prot... 73 5e-12
UniRef50_Q39MY1 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 73 5e-12
UniRef50_Q1GJB9 Cluster: 6-phosphogluconate dehydrogenase NAD-bi... 73 5e-12
UniRef50_Q49A26 Cluster: Cytokine-like nuclear factor n-pac; n=4... 73 5e-12
UniRef50_A7IE35 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 73 6e-12
UniRef50_A3K497 Cluster: Probable 6-phosphogluconate dehydrogena... 73 6e-12
UniRef50_A0C2T7 Cluster: Chromosome undetermined scaffold_145, w... 73 6e-12
UniRef50_Q0LNZ7 Cluster: 3-hydroxyisobutyrate dehydrogenase prec... 73 8e-12
UniRef50_A1CAY2 Cluster: Oxidoreductase, acting on the CH-OH gro... 73 8e-12
UniRef50_A3H5R1 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 73 8e-12
UniRef50_Q1N6I0 Cluster: Putative oxidoreductase protein; n=1; O... 72 1e-11
UniRef50_A3H9B3 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 72 1e-11
UniRef50_O33730 Cluster: Uncharacterized oxidoreductase Sfri_150... 72 1e-11
UniRef50_Q89RT2 Cluster: Bll2680 protein; n=1; Bradyrhizobium ja... 72 1e-11
UniRef50_Q0RCX7 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 71 2e-11
UniRef50_A0G5F9 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 71 2e-11
UniRef50_A1WM48 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 71 3e-11
UniRef50_A0NRG5 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 71 3e-11
UniRef50_Q8VYC5 Cluster: Fructose-bisphosphate aldolase; n=12; c... 71 3e-11
UniRef50_Q7WNK6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 70 4e-11
UniRef50_Q0F1Y7 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 70 4e-11
UniRef50_A0GPK7 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 70 4e-11
UniRef50_Q830A7 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 70 6e-11
UniRef50_Q84VC8 Cluster: Gamma hydroxybutyrate dehydrogenase-lik... 70 6e-11
UniRef50_Q7WCG3 Cluster: Putative uncharacterized protein; n=2; ... 69 7e-11
UniRef50_Q39FA8 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 69 7e-11
UniRef50_A6EH53 Cluster: Putative uncharacterized protein; n=1; ... 69 7e-11
UniRef50_A5P0V0 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 69 7e-11
UniRef50_A1ZWM5 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 69 7e-11
UniRef50_Q98I20 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 69 1e-10
UniRef50_Q47AR2 Cluster: NADP oxidoreductase, coenzyme F420-depe... 69 1e-10
UniRef50_A3X9R7 Cluster: 3-hydroxyisobutyrate dehydrogenase fami... 69 1e-10
UniRef50_Q94B07 Cluster: Gamma hydroxybutyrate dehydrogenase; n=... 69 1e-10
UniRef50_A5GPC0 Cluster: Hydroxyacid dehydrogenase/reductase fam... 68 2e-10
UniRef50_P77161 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 68 2e-10
UniRef50_Q1IQE6 Cluster: 2-hydroxy-3-oxopropionate reductase pre... 67 3e-10
UniRef50_Q8EW87 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 67 4e-10
UniRef50_Q606G9 Cluster: Oxidoreductase, Gfo/Idh/MocA family; n=... 67 4e-10
UniRef50_A5VBF0 Cluster: 2-hydroxy-3-oxopropionate reductase pre... 66 5e-10
UniRef50_A1UJF2 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 66 5e-10
UniRef50_A0R1N4 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 66 7e-10
UniRef50_A4SWE8 Cluster: 2-hydroxy-3-oxopropionate reductase pre... 65 1e-09
UniRef50_A4ECY9 Cluster: Putative uncharacterized protein; n=1; ... 65 1e-09
UniRef50_A0FZ96 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 65 1e-09
UniRef50_Q01QM2 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 65 2e-09
UniRef50_A0JXR2 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 65 2e-09
UniRef50_Q6UCZ9 Cluster: Predicted oxidoreductase; n=2; environm... 64 2e-09
UniRef50_Q0FFH2 Cluster: Putative 2-hydroxyacid dehydrogenase; n... 64 2e-09
UniRef50_A5FTT0 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 64 3e-09
UniRef50_A2C1U6 Cluster: 3-hydroxyisobutyrate dehydrogenase and ... 64 3e-09
UniRef50_Q1EPJ1 Cluster: 6-phosphogluconate dehydrogenase NAD-bi... 64 3e-09
UniRef50_Q121N3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 64 4e-09
UniRef50_P71825 Cluster: Uncharacterized oxidoreductase Rv0770/M... 64 4e-09
UniRef50_Q89M84 Cluster: Blr4309 protein; n=6; Bradyrhizobiaceae... 63 5e-09
UniRef50_Q0KC92 Cluster: 3-Hydroxyisobutyrate dehydrogenase; n=1... 63 5e-09
UniRef50_UPI0001597301 Cluster: YfjR; n=1; Bacillus amyloliquefa... 63 6e-09
UniRef50_A6G049 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 63 6e-09
UniRef50_Q3W9W7 Cluster: 6-phosphogluconate dehydrogenase, NAD b... 62 9e-09
UniRef50_Q13PY3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 62 1e-08
UniRef50_Q0URA2 Cluster: Putative uncharacterized protein; n=1; ... 62 1e-08
UniRef50_Q74D68 Cluster: 3-hydroxyisobutyrate dehydrogenase fami... 62 1e-08
UniRef50_Q9LM23 Cluster: Fructose-bisphosphate aldolase; n=2; Ar... 62 1e-08
UniRef50_A7H7Z5 Cluster: 6-phosphogluconate dehydrogenase NAD-bi... 61 2e-08
UniRef50_A6R0U9 Cluster: Predicted protein; n=1; Ajellomyces cap... 61 2e-08
UniRef50_Q3W3N3 Cluster: Putative uncharacterized protein; n=1; ... 61 3e-08
UniRef50_A6VLT0 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 61 3e-08
UniRef50_Q019Z7 Cluster: Oxidoreductase-like; n=1; Ostreococcus ... 61 3e-08
UniRef50_Q7NR40 Cluster: Probable 3-hydroxyisobutyrate dehydroge... 60 3e-08
UniRef50_Q13LQ9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 60 5e-08
UniRef50_A6VYD9 Cluster: 2-hydroxy-3-oxopropionate reductase pre... 60 5e-08
UniRef50_A1GFG2 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 60 5e-08
UniRef50_Q3W9L4 Cluster: Putative uncharacterized protein; n=1; ... 59 8e-08
UniRef50_Q20XN2 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 59 8e-08
UniRef50_A0JRK4 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 59 8e-08
UniRef50_Q656T5 Cluster: Oxidoreductase-like; n=3; Oryza sativa|... 59 8e-08
UniRef50_A3Y8R5 Cluster: Putative dehydrogenase; n=1; Marinomona... 59 1e-07
UniRef50_A0LDJ3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 59 1e-07
UniRef50_Q1GF31 Cluster: 6-phosphogluconate dehydrogenase NAD-bi... 58 1e-07
UniRef50_Q033P2 Cluster: 3-hydroxyisobutyrate dehydrogenase rela... 58 1e-07
UniRef50_A6F020 Cluster: Putative uncharacterized protein; n=1; ... 58 1e-07
UniRef50_A5WG80 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 58 1e-07
UniRef50_Q39KK8 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 58 2e-07
UniRef50_Q392H4 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 58 2e-07
UniRef50_Q2BFK1 Cluster: Oxidoreductase; n=1; Bacillus sp. NRRL ... 58 2e-07
UniRef50_A1WJN2 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 58 2e-07
UniRef50_A7RG59 Cluster: Predicted protein; n=1; Nematostella ve... 58 2e-07
UniRef50_Q2CHC8 Cluster: Oxidoreductase; n=1; Oceanicola granulo... 58 2e-07
UniRef50_Q5LQR0 Cluster: 6-phosphogluconate dehydrogenase domain... 57 3e-07
UniRef50_Q5FQ06 Cluster: Putative oxidoreductase; n=1; Gluconoba... 57 3e-07
UniRef50_A0RU56 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 57 3e-07
UniRef50_A5P600 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 57 4e-07
UniRef50_Q8PK98 Cluster: 3-hydroxyisobutirate dehydrogenase; n=3... 56 7e-07
UniRef50_Q2JEN4 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 56 7e-07
UniRef50_Q120Q9 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 56 7e-07
UniRef50_Q6C351 Cluster: Yarrowia lipolytica chromosome F of str... 56 7e-07
UniRef50_A0AWL7 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 56 1e-06
UniRef50_Q98K09 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=7... 55 1e-06
UniRef50_Q6F842 Cluster: Putative 3-hydroxyisobutyrate dehydroge... 55 1e-06
UniRef50_Q82ZC2 Cluster: 6-phosphogluconate dehydrogenase family... 55 2e-06
UniRef50_Q46TQ0 Cluster: UDP-glucose/GDP-mannose dehydrogenase:P... 55 2e-06
UniRef50_O66454 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3... 55 2e-06
UniRef50_Q0UVR9 Cluster: Putative uncharacterized protein; n=1; ... 55 2e-06
UniRef50_Q3WJ00 Cluster: 6-phosphogluconate dehydrogenase, NAD b... 54 2e-06
UniRef50_A3WMG5 Cluster: Probable 3-hydroxyisobutyrate dehydroge... 54 3e-06
UniRef50_Q7Q161 Cluster: ENSANGP00000013149; n=11; Culicidae|Rep... 54 3e-06
UniRef50_A6RMW8 Cluster: Putative uncharacterized protein; n=2; ... 54 3e-06
UniRef50_Q6RXW5 Cluster: Succinic semialdehyde dehydrogenase; n=... 54 4e-06
UniRef50_Q21ZN3 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 54 4e-06
UniRef50_Q12H32 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 54 4e-06
UniRef50_A3EW86 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 54 4e-06
UniRef50_Q4PCH4 Cluster: Putative uncharacterized protein; n=1; ... 54 4e-06
UniRef50_Q9JYH6 Cluster: 3-hydroxyacid dehydrogenase; n=5; Prote... 53 5e-06
UniRef50_Q9RX16 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=6... 53 7e-06
UniRef50_Q2UHA9 Cluster: Predicted dehydrogenase; n=16; Pezizomy... 53 7e-06
UniRef50_A1UDJ6 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 52 9e-06
UniRef50_A0R1N5 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 52 9e-06
UniRef50_Q9I1R8 Cluster: Probable dehydrogenase; n=7; Pseudomona... 52 1e-05
UniRef50_A5FVG0 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 52 1e-05
UniRef50_Q89GM2 Cluster: Bll6323 protein; n=6; Proteobacteria|Re... 52 2e-05
UniRef50_A1SQ87 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 52 2e-05
UniRef50_Q92P61 Cluster: 6-phosphogluconate dehydrogenase, decar... 51 2e-05
UniRef50_Q4Q9Z1 Cluster: Dehydrogenase-like protein; n=6; Trypan... 51 2e-05
UniRef50_Q9HLR4 Cluster: Putative uncharacterized protein Ta0161... 51 2e-05
UniRef50_Q3W031 Cluster: Putative dehydrogenase; n=1; Frankia sp... 51 3e-05
UniRef50_Q220G7 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 51 3e-05
UniRef50_A3ET09 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3... 50 4e-05
UniRef50_Q8F4I7 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=4... 50 5e-05
UniRef50_Q7VYY0 Cluster: Putative oxidoreductase; n=4; Bordetell... 50 5e-05
UniRef50_Q21ZT0 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 50 5e-05
UniRef50_A3ES45 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 50 5e-05
UniRef50_Q9V8M5-2 Cluster: Isoform C of Q9V8M5 ; n=1; Drosophila... 50 6e-05
UniRef50_A1UJF3 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 50 6e-05
UniRef50_Q5GUM4 Cluster: Dehydrogenase; n=5; Gammaproteobacteria... 49 9e-05
UniRef50_Q0C8I2 Cluster: Predicted protein; n=3; Pezizomycotina|... 49 9e-05
UniRef50_Q6KZX0 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 49 1e-04
UniRef50_Q0BTJ3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 48 1e-04
UniRef50_A5CN67 Cluster: Putative beta-hydroxyacid dehydrogenase... 48 1e-04
UniRef50_A4FKN9 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 48 1e-04
UniRef50_Q5LNV6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2... 48 2e-04
UniRef50_Q0RIL5 Cluster: Putative uncharacterized protein; n=1; ... 48 2e-04
UniRef50_A3Q3U7 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 48 2e-04
UniRef50_Q0U6Q6 Cluster: Putative uncharacterized protein; n=5; ... 48 2e-04
UniRef50_Q9RU02 Cluster: 6-phosphogluconate dehydrogenase; n=24;... 48 3e-04
UniRef50_Q1V2K7 Cluster: NADP oxidoreductase, coenzyme F420-depe... 47 3e-04
UniRef50_Q1INE9 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 47 3e-04
UniRef50_Q1GM24 Cluster: 6-phosphogluconate dehydrogenase NAD-bi... 47 3e-04
UniRef50_Q97ZE5 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=4... 47 3e-04
UniRef50_O66788 Cluster: 6-phosphogluconate dehydrogenase; n=2; ... 47 5e-04
UniRef50_Q6D9X4 Cluster: Putative 2-hydroxy-3-oxopropionate redu... 46 6e-04
UniRef50_Q0W2D7 Cluster: Putative 6-phosphogluconate dehydrogena... 46 6e-04
UniRef50_Q3J9H5 Cluster: 6-phosphogluconate dehydrogenase, decar... 46 8e-04
UniRef50_Q9RBX6 Cluster: IgiB; n=1; Vogesella indigofera|Rep: Ig... 46 8e-04
UniRef50_Q4WXG9 Cluster: 3-hydroxyisobutyrate dehydrogenase, put... 46 8e-04
UniRef50_A2BJA4 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 46 8e-04
UniRef50_Q7NEW9 Cluster: Glr3759 protein; n=3; Bacteria|Rep: Glr... 45 0.002
UniRef50_Q0SAG5 Cluster: Phosphogluconate dehydrogenase; n=23; A... 45 0.002
UniRef50_A0K107 Cluster: 2-hydroxy-3-oxopropionate reductase; n=... 45 0.002
UniRef50_A3LTC4 Cluster: 3-hydroxyisobutyrate dehydrogenase-like... 45 0.002
UniRef50_Q19TN0 Cluster: 3-hydroxyisobutyrate dehydrogenase fami... 44 0.002
UniRef50_Q21AH6 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 44 0.003
UniRef50_Q8TUC1 Cluster: Predicted protein; n=4; Methanosarcinac... 44 0.003
UniRef50_A3H6C3 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 44 0.003
UniRef50_P80859 Cluster: 6-phosphogluconate dehydrogenase, decar... 44 0.003
UniRef50_A6ELE2 Cluster: 6-phosphogluconate dehydrogenase, decar... 44 0.004
UniRef50_A0YMN9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3... 43 0.006
UniRef50_A3PSD9 Cluster: 6-phosphogluconate dehydrogenase, decar... 43 0.007
UniRef50_A0GI22 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 43 0.007
UniRef50_A4EEN1 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 42 0.013
UniRef50_A2Q7E9 Cluster: Function: mmsB of P. aeruginosa is invo... 42 0.013
UniRef50_Q8YRT5 Cluster: 3-hydroxyacid dehydrogenase; n=5; Cyano... 42 0.017
UniRef50_Q64V77 Cluster: 6-phosphogluconate dehydrogenase, decar... 42 0.017
UniRef50_Q2UET7 Cluster: Predicted protein; n=7; Eurotiomycetida... 42 0.017
UniRef50_Q9LNP0 Cluster: F1L3.35; n=8; Magnoliophyta|Rep: F1L3.3... 41 0.023
UniRef50_Q5FHQ8 Cluster: 6-phosphogluconate dehydrogenase, decar... 41 0.030
UniRef50_A0VSV4 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 41 0.030
UniRef50_Q1AZK2 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 40 0.039
UniRef50_Q4WSB8 Cluster: 6-phosphogluconate dehydrogenase family... 40 0.052
UniRef50_A1RWA6 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 40 0.052
UniRef50_Q17761 Cluster: 6-phosphogluconate dehydrogenase, decar... 40 0.069
UniRef50_Q1NHG5 Cluster: Putative uncharacterized protein; n=1; ... 39 0.12
UniRef50_A4ENK2 Cluster: 3-demethylubiquinone-9 3-methyltransfer... 39 0.12
UniRef50_Q660W3 Cluster: 6-phosphogluconate dehydrogenase, decar... 38 0.16
UniRef50_Q9YFQ6 Cluster: L-lysine 6-dehydrogenase; n=1; Aeropyru... 38 0.21
UniRef50_P54448 Cluster: Uncharacterized protein yqeC; n=13; Bac... 38 0.21
UniRef50_O34969 Cluster: Uncharacterized oxidoreductase yfjR; n=... 38 0.21
UniRef50_P31072 Cluster: 6-phosphogluconate dehydrogenase, decar... 38 0.21
UniRef50_Q1NHF5 Cluster: Putative oxidoreductase; n=1; Sphingomo... 38 0.28
UniRef50_A6T947 Cluster: Putative dehydrogenase; n=1; Klebsiella... 38 0.28
UniRef50_P21577 Cluster: 6-phosphogluconate dehydrogenase, decar... 38 0.28
UniRef50_Q1YSL7 Cluster: Putative uncharacterized protein; n=1; ... 37 0.49
UniRef50_A5K3L2 Cluster: 6-phosphogluconate dehydrogenase, decar... 37 0.49
UniRef50_Q988C8 Cluster: 3-hydroxybutyryl-coA dehydrogenase; n=1... 36 0.64
UniRef50_Q1YFU0 Cluster: Posibble methylase involved in ubiquino... 36 0.64
UniRef50_Q8U2W2 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 36 0.64
UniRef50_Q1K0U0 Cluster: Prephenate dehydrogenase precursor; n=4... 36 0.85
UniRef50_A4ES45 Cluster: Methyltransferase type 11; n=1; Roseoba... 36 0.85
UniRef50_A4ARS6 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 36 0.85
UniRef50_A6RYG0 Cluster: Putative uncharacterized protein; n=1; ... 36 0.85
UniRef50_Q944B6 Cluster: Arogenate dehydrogenase 1, chloroplast ... 36 0.85
UniRef50_Q0RMX6 Cluster: Putative reductase; n=1; Frankia alni A... 36 1.1
UniRef50_A6W129 Cluster: 6-phosphogluconate dehydrogenase, decar... 36 1.1
UniRef50_A4JSC3 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 36 1.1
UniRef50_Q2LGT9 Cluster: 6-phosphogluconate dehydrogenase; n=6; ... 36 1.1
UniRef50_Q5PAV2 Cluster: 3-demethylubiquinone-9 3-methyltransfer... 35 1.5
UniRef50_Q2J7U0 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 35 1.5
UniRef50_Q1N6E5 Cluster: Erythronate-4-phosphate dehydrogenase; ... 35 1.5
UniRef50_A6VZU5 Cluster: D-isomer specific 2-hydroxyacid dehydro... 35 1.5
UniRef50_A4SGI3 Cluster: NAD-dependent epimerase/dehydratase; n=... 35 1.5
UniRef50_A0Y665 Cluster: 6-phosphogluconate dehydrogenase; n=3; ... 35 1.5
UniRef50_A0QZR7 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1... 35 1.5
UniRef50_A1U1I8 Cluster: Erythronate-4-phosphate dehydrogenase; ... 35 1.5
UniRef50_UPI0000E46E06 Cluster: PREDICTED: similar to MGC107852 ... 35 2.0
UniRef50_Q2S7E0 Cluster: Phosphoglycerate dehydrogenase and rela... 35 2.0
UniRef50_A4XCN7 Cluster: Methyltransferase type 11; n=2; Salinis... 35 2.0
UniRef50_A3Y0Y8 Cluster: Putative tartronate semialdehyde reduct... 35 2.0
UniRef50_A3U721 Cluster: Putative uncharacterized protein; n=1; ... 35 2.0
UniRef50_UPI0000E221EA Cluster: PREDICTED: similar to NMDAR1 sub... 34 2.6
UniRef50_UPI000050FDFD Cluster: COG0569: K+ transport systems, N... 34 2.6
UniRef50_Q7WCB1 Cluster: 3-hydroxybutyryl-CoA dehydrogenase; n=4... 34 2.6
UniRef50_Q11JE9 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 34 2.6
UniRef50_A4BV63 Cluster: 3-hydroxyacid dehydrogenase; n=1; Nitro... 34 2.6
UniRef50_Q55W03 Cluster: Putative uncharacterized protein; n=2; ... 34 2.6
UniRef50_Q3DWX0 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 34 3.4
UniRef50_O32911 Cluster: 6-phosphogluconate dehydrogenase, decar... 34 3.4
UniRef50_A6G079 Cluster: Leucine dehydrogenase; n=1; Plesiocysti... 34 3.4
UniRef50_UPI0000E8153F Cluster: PREDICTED: hypothetical protein;... 33 4.5
UniRef50_Q88J51 Cluster: Oxidoreductase, putative; n=6; Pseudomo... 33 4.5
UniRef50_Q6N3Q8 Cluster: 6-phosphogluconate dehydrogenase; n=57;... 33 4.5
UniRef50_Q9RQV3 Cluster: Putative prephenate dehydrogenase TyrC;... 33 4.5
UniRef50_Q0S6F7 Cluster: 3-demethylubiquinone-9 3-O-methyltransf... 33 4.5
UniRef50_A7CWR7 Cluster: 6-phosphogluconate dehydrogenase NAD-bi... 33 4.5
UniRef50_A0Z3U5 Cluster: Putative uncharacterized protein; n=1; ... 33 4.5
UniRef50_A7QQA4 Cluster: Chromosome undetermined scaffold_141, w... 33 4.5
UniRef50_Q5KFL3 Cluster: Putative uncharacterized protein; n=2; ... 33 4.5
UniRef50_Q0VQC3 Cluster: Erythronate-4-phosphate dehydrogenase; ... 33 4.5
UniRef50_Q88ZU6 Cluster: Phosphoglycerate dehydrogenase; n=2; La... 33 6.0
UniRef50_Q7TZG1 Cluster: 6-phosphogluconate dehydrogenase, decar... 33 6.0
UniRef50_Q6F272 Cluster: 1-pyrroline-5-carboxylate reductase; n=... 33 6.0
UniRef50_O67636 Cluster: Prephenate dehydrogenase; n=1; Aquifex ... 33 6.0
UniRef50_Q2BJD5 Cluster: Probable UDP-glucose/GDP-mannose dehydr... 33 6.0
UniRef50_A6TCR4 Cluster: 2-ketoacid reductase; n=1; Klebsiella p... 33 6.0
UniRef50_A6NX21 Cluster: Putative uncharacterized protein; n=1; ... 33 6.0
UniRef50_A0Q3X1 Cluster: Putative uncharacterized protein; n=1; ... 33 6.0
UniRef50_Q8SRX1 Cluster: 6-PHOSPHOGLUCONATE DEHYDROGENASE; n=1; ... 33 6.0
UniRef50_Q82ZY7 Cluster: Potassium uptake protein; n=3; Bacilli|... 33 7.9
UniRef50_Q5NLA3 Cluster: Phosphoglycerate dehydrogenase; n=1; Zy... 33 7.9
UniRef50_Q0SBI0 Cluster: Probable oxidoreductase; n=1; Rhodococc... 33 7.9
UniRef50_A7IIH0 Cluster: D-isomer specific 2-hydroxyacid dehydro... 33 7.9
UniRef50_A1FPN2 Cluster: 6-phosphogluconate dehydrogenase, NAD-b... 33 7.9
UniRef50_A0LNU5 Cluster: Ubiquinone biosynthesis O-methyltransfe... 33 7.9
>UniRef50_Q7NWA9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=7;
Proteobacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Chromobacterium violaceum
Length = 296
Score = 126 bits (304), Expect = 5e-28
Identities = 66/142 (46%), Positives = 83/142 (58%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+N+AF+GLGNMGG MA NL+ KGF V +D S DAL A G A+S
Sbjct: 2 ENIAFIGLGNMGGPMAVNLLNKGFKVSAFDLSADALAKVAAAGGRAASSAADAAESASVV 61
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
S+L + K V +YLG +G+ A KG+L+ID STID +++ A EKGL DAPV
Sbjct: 62 ISMLPAGKHVAGLYLGDNGLFARLPKGALVIDCSTIDAGTARKVAEGAREKGLSMLDAPV 121
Query: 506 SGGVMGAXNATLAFMAGGRKED 571
SGG GA TL F+ GG ED
Sbjct: 122 SGGTAGAAAGTLTFIVGGAAED 143
>UniRef50_A7UBP6 Cluster: Putative 3-hydroxyisobutyrate
dehydrogenase; n=1; Paracoccus methylutens|Rep: Putative
3-hydroxyisobutyrate dehydrogenase - Paracoccus
methylutens
Length = 302
Score = 123 bits (296), Expect = 4e-27
Identities = 64/144 (44%), Positives = 85/144 (59%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V FLGLG MG MA NL G V YDPS++ AAK G+ A+ + +
Sbjct: 4 VGFLGLGRMGFPMARNLATAGHDVHVYDPSEEVGRKAAKAGLKTASRVDVAVEGADFVIT 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
++ + + VL+++LG DGV+A KGS+ IDSSTID +++ E+G+ DAPVSG
Sbjct: 64 MVPTGRHVLEIFLGDDGVLAKMAKGSMAIDSSTIDTADARRLHAAGRERGIAVLDAPVSG 123
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
GVMGA TL FM GG ED ER+
Sbjct: 124 GVMGAEAGTLTFMVGGSAEDLERA 147
>UniRef50_A0JUJ6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Micrococcineae|Rep: 3-hydroxyisobutyrate dehydrogenase -
Arthrobacter sp. (strain FB24)
Length = 300
Score = 122 bits (294), Expect = 8e-27
Identities = 64/136 (47%), Positives = 82/136 (60%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
VA++GLGNMGG M+ANL K G VRG+D + +A+ AA GV P SI +
Sbjct: 4 VAWIGLGNMGGSMSANLAKAGHDVRGFDLNPEAVAAAEAGGVKPVASIAAAVDGADVVFT 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L + VYLG+DGV+AHA + +LL+DSSTID + + A G F DAPVSG
Sbjct: 64 MLPKGEHARAVYLGEDGVLAHADRRTLLVDSSTIDIASAQALHDAAAAAGFRFVDAPVSG 123
Query: 512 GVMGAXNATLAFMAGG 559
G+ GA TL FM GG
Sbjct: 124 GMSGAKAGTLTFMIGG 139
>UniRef50_Q54CX6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3;
cellular organisms|Rep: 3-hydroxyisobutyrate
dehydrogenase - Dictyostelium discoideum AX4
Length = 321
Score = 119 bits (287), Expect = 5e-26
Identities = 61/151 (40%), Positives = 87/151 (57%)
Frame = +2
Query: 122 RAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXX 301
R S+++ K V F+GLGNMGG A NL+KKG + +D SKD +N + G ANS
Sbjct: 15 RYMSTSSSKTVGFIGLGNMGGHQAINLIKKGHNLIVFDMSKDNMNRLKEKGAKIANSPAE 74
Query: 302 XXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG 481
++L ++ V +VY G++G+ + G+LL+DSSTIDP +++ IA +
Sbjct: 75 VAKEADVIVTMLPASAHVKNVYCGENGIFQTVRPGTLLLDSSTIDPATAREVASIAKKHQ 134
Query: 482 LGFTDAPVSGGVMGAXNATLAFMAGGRKEDF 574
D PVSGG GA TL FM GG ++DF
Sbjct: 135 STMLDCPVSGGTGGAEAGTLTFMVGGSEQDF 165
>UniRef50_A7JGH8 Cluster: Predicted protein; n=1; Francisella
tularensis subsp. novicida GA99-3549|Rep: Predicted
protein - Francisella tularensis subsp. novicida
GA99-3549
Length = 293
Score = 117 bits (282), Expect = 2e-25
Identities = 65/145 (44%), Positives = 81/145 (55%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
KN+AF+GLG MG MA NL+ G+ V G+D S D LN NG A SI
Sbjct: 2 KNIAFIGLGCMGLHMAKNLIDNGYKVYGFDMSLDQLNKHQNNGGIAAKSIKEACGYADAI 61
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
L V +V DG++ AK G+++ID+STID N + A + L DAPV
Sbjct: 62 ILSLPGPNQVSNVCDSSDGILKIAKAGTIIIDTSTIDANTSVLLAKKAKQNNLHMLDAPV 121
Query: 506 SGGVMGAXNATLAFMAGGRKEDFER 580
SGG++GA NATL FM GG KE FER
Sbjct: 122 SGGIIGAQNATLTFMVGGDKEIFER 146
>UniRef50_UPI0000D56743 Cluster: PREDICTED: similar to
3-hydroxyisobutyrate dehydrogenase; n=1; Tribolium
castaneum|Rep: PREDICTED: similar to
3-hydroxyisobutyrate dehydrogenase - Tribolium castaneum
Length = 315
Score = 115 bits (277), Expect = 9e-25
Identities = 62/139 (44%), Positives = 80/139 (57%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AF+G+GNMG MA NLVKKG TVR +D + NA + G N+ +
Sbjct: 26 LAFIGIGNMGSRMANNLVKKGETVRVFDLTP--ANAKSVPGAQVCNNQEEAVKDASVIIT 83
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L + +V D LG +G++ HA KGSLLID STI P V +++ G F DAPVSG
Sbjct: 84 MLPNGDIVKDTVLGTNGILKHASKGSLLIDCSTIQPQVAQEVSKATYSAGFKFLDAPVSG 143
Query: 512 GVMGAXNATLAFMAGGRKE 568
GV GA TL FM GG K+
Sbjct: 144 GVTGAEAGTLTFMVGGDKQ 162
>UniRef50_P28811 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=72;
Proteobacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Pseudomonas aeruginosa
Length = 298
Score = 110 bits (264), Expect = 3e-23
Identities = 62/145 (42%), Positives = 81/145 (55%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
++AFLGLGNMGG MAANL+K G V +D A+ + G A+S
Sbjct: 3 DIAFLGLGNMGGPMAANLLKAGHRVNVFDLQPKAVLGLVEQGAQGADSALQCCEGAEVVI 62
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
S+L + + V +YLG DG++A LLID STI P +++ A KGL DAPVS
Sbjct: 63 SMLPAGQHVESLYLGDDGLLARVAGKPLLIDCSTIAPETARKVAEAAAAKGLTLLDAPVS 122
Query: 509 GGVMGAXNATLAFMAGGRKEDFERS 583
GGV GA TL+F+ GG E F R+
Sbjct: 123 GGVGGARAGTLSFIVGGPAEGFARA 147
>UniRef50_Q4FMJ3 Cluster: 6-phosphogluconate dehydrogenase; n=2;
Candidatus Pelagibacter ubique|Rep: 6-phosphogluconate
dehydrogenase - Pelagibacter ubique
Length = 289
Score = 108 bits (260), Expect = 1e-22
Identities = 54/147 (36%), Positives = 89/147 (60%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+N++F+G+G MG MA NL+K GF +R Y+ S+D + + G + SI
Sbjct: 2 QNISFIGIGLMGFPMAKNLLKSGFNLRAYNRSQDKADRLKEFGAEISTSIKDVVTNSDVI 61
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
++LT + V V +G D +++ K+G+ +ID S+++P + K+ F I EK + + DAPV
Sbjct: 62 ITMLTDDAAVEKV-MGSDEFISNIKEGATVIDMSSVNPVITKKYFKILKEKNINYLDAPV 120
Query: 506 SGGVMGAXNATLAFMAGGRKEDFERSF 586
SGG +GA A+LA M GG +E F++ +
Sbjct: 121 SGGTIGAEEASLAIMVGGDEETFKQCY 147
>UniRef50_A3I4V2 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Bacillus sp. B14905|Rep: 3-hydroxyisobutyrate
dehydrogenase - Bacillus sp. B14905
Length = 316
Score = 108 bits (260), Expect = 1e-22
Identities = 55/145 (37%), Positives = 86/145 (59%)
Frame = +2
Query: 143 DKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXX 322
++ + F+GLGNMG M+ NL+K + V G+D + A+ + G S
Sbjct: 21 NRKLGFIGLGNMGLPMSINLLKANYEVYGFDTNAKAVELFTEAGGIGLASAKDVAKQCDV 80
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
+ L + ++V VYL ++G++ HAKKG+LL+D ST++P++ + A GL + AP
Sbjct: 81 VMTSLPTPQIVEMVYLSEEGIIHHAKKGALLVDFSTVNPDLNDSLHKEASTLGLRYLGAP 140
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFE 577
VSGGV+GA NATL M GG K+D++
Sbjct: 141 VSGGVIGAVNATLTIMVGGGKDDYD 165
>UniRef50_Q0SBQ9 Cluster: 2-hydroxy-3-oxopropionate reductase; n=12;
Actinomycetales|Rep: 2-hydroxy-3-oxopropionate reductase
- Rhodococcus sp. (strain RHA1)
Length = 294
Score = 107 bits (256), Expect = 3e-22
Identities = 60/142 (42%), Positives = 76/142 (53%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AF+GLG MG MA NL K G V GY+ D A + G T A+SI
Sbjct: 4 IAFIGLGIMGSPMACNLAKAGHQVVGYNLIPDRTAALVEAGGTAADSIAKAVAGADVVAV 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
++ + V V G+DGV H G+L+ID S+I P+V + A E+G DAPVSG
Sbjct: 64 MVPDSPDVQAVLTGEDGVFEHTPSGALIIDFSSIRPDVTTALAAQATERGFRLIDAPVSG 123
Query: 512 GVMGAXNATLAFMAGGRKEDFE 577
G GA NA L+ M GG EDFE
Sbjct: 124 GEAGAVNAALSIMVGGAPEDFE 145
>UniRef50_A0UF54 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Burkholderia multivorans ATCC
17616|Rep: 6-phosphogluconate dehydrogenase, NAD-binding
- Burkholderia multivorans ATCC 17616
Length = 289
Score = 107 bits (256), Expect = 3e-22
Identities = 53/141 (37%), Positives = 79/141 (56%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
K V +GLGNMG +A++L + GF V G+D + +++ A GV P S+
Sbjct: 2 KTVGVIGLGNMGRGIASSLKRAGFDVLGFDANAESVRQLADEGVRPCASVAEIASAVDVL 61
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
L ++ +V V LG GV +HAK+G ++ID++T DPN +++ G+GF D PV
Sbjct: 62 ILSLPTSAIVEAVVLGDGGVASHAKRGLIVIDTTTADPNSTRKVAAALDAHGIGFIDGPV 121
Query: 506 SGGVMGAXNATLAFMAGGRKE 568
SGG GA AT+ + GG E
Sbjct: 122 SGGPKGAATATMTMVLGGADE 142
>UniRef50_UPI00015B4162 Cluster: PREDICTED: similar to MGC108315
protein; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to MGC108315 protein - Nasonia vitripennis
Length = 276
Score = 105 bits (253), Expect = 7e-22
Identities = 52/122 (42%), Positives = 73/122 (59%)
Frame = +2
Query: 104 LYTAARRAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTP 283
+YT R NV F+GLGNMGGFMA NL+KKG+ + +D +K A++ G
Sbjct: 13 IYTVGR--VGQRDFSNVGFVGLGNMGGFMAKNLLKKGYKLTVFDINKTAIDNVVSAGAKG 70
Query: 284 ANSIXXXXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFP 463
A S+ ++L N+ VLD Y GKDG+++ AKKG+ L+DSSTIDP+V + +F
Sbjct: 71 AESVAEVSQNSEVIVTMLPMNQHVLDTYTGKDGIISSAKKGTFLVDSSTIDPSVSQTVFK 130
Query: 464 IA 469
A
Sbjct: 131 AA 132
>UniRef50_Q399N0 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=72;
cellular organisms|Rep: 3-hydroxyisobutyrate
dehydrogenase - Burkholderia sp. (strain 383)
(Burkholderia cepacia (strain ATCC 17760/ NCIB 9086 /
R18194))
Length = 299
Score = 105 bits (251), Expect = 1e-21
Identities = 60/143 (41%), Positives = 75/143 (52%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG+MG MA NL+K G V +D S DAL A G A S +
Sbjct: 3 IGFIGLGHMGAPMALNLLKAGHEVHAFDLSADALRALQDAGAQVAASPRDAASGATFVIT 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L + V V G++GV+A G+ +IDSSTIDP + + E G F DAPVSG
Sbjct: 63 MLPAAPHVRSVLSGENGVLAGLGAGATVIDSSTIDPASAQAFGALVREHGGAFVDAPVSG 122
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
G GA TL FM GG DFER
Sbjct: 123 GTGGAAAGTLTFMVGGSDADFER 145
>UniRef50_A1QPH6 Cluster: 3-hydroxyisobutyrate dehydrogenase mmsB;
n=5; Mycobacterium|Rep: 3-hydroxyisobutyrate
dehydrogenase mmsB - Mycobacterium tuberculosis (strain
F11)
Length = 315
Score = 105 bits (251), Expect = 1e-21
Identities = 61/144 (42%), Positives = 81/144 (56%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AFLGLGNMG M+ANLV G VRG+DP+ A + AA +GV S +
Sbjct: 4 IAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFRSAPEAVAEADVVIT 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L + +VV Y V+A A+ +L IDSSTI +++ +A G+ DAPVSG
Sbjct: 64 MLPTGEVVRRCYTD---VLAAARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSG 120
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
GV GA ATLAFM GG + R+
Sbjct: 121 GVKGAAAATLAFMVGGDESTLRRA 144
>UniRef50_P63936 Cluster: Probable 3-hydroxyisobutyrate
dehydrogenase; n=25; Bacteria|Rep: Probable
3-hydroxyisobutyrate dehydrogenase - Mycobacterium bovis
Length = 294
Score = 105 bits (251), Expect = 1e-21
Identities = 61/144 (42%), Positives = 81/144 (56%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AFLGLGNMG M+ANLV G VRG+DP+ A + AA +GV S +
Sbjct: 4 IAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFRSAPEAVAEADVVIT 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L + +VV Y V+A A+ +L IDSSTI +++ +A G+ DAPVSG
Sbjct: 64 MLPTGEVVRRCYTD---VLAAARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSG 120
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
GV GA ATLAFM GG + R+
Sbjct: 121 GVKGAAAATLAFMVGGDESTLRRA 144
>UniRef50_P31937 Cluster: 3-hydroxyisobutyrate dehydrogenase,
mitochondrial precursor; n=38; Eumetazoa|Rep:
3-hydroxyisobutyrate dehydrogenase, mitochondrial
precursor - Homo sapiens (Human)
Length = 336
Score = 104 bits (249), Expect = 2e-21
Identities = 60/151 (39%), Positives = 83/151 (54%)
Frame = +2
Query: 122 RAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXX 301
R+ +S T V F+GLGNMG MA NL+K G+ + YD DA G +S
Sbjct: 34 RSVASKTP--VGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPAD 91
Query: 302 XXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG 481
++L ++ ++ Y G +G++ KKGSLLIDSSTIDP V K++ + G
Sbjct: 92 VAEKADRIITMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMG 151
Query: 482 LGFTDAPVSGGVMGAXNATLAFMAGGRKEDF 574
F DAPVSGGV A + L FM GG +++F
Sbjct: 152 AVFMDAPVSGGVGAARSGNLTFMVGGVEDEF 182
>UniRef50_A0QSJ0 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3;
Bacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length = 290
Score = 101 bits (243), Expect = 1e-20
Identities = 60/144 (41%), Positives = 77/144 (53%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AFLGLG+MGG MAANL G TVRG+DP + AA G+ + +
Sbjct: 4 IAFLGLGHMGGPMAANLAAAGHTVRGFDPMPASREAAEAKGIKVFGTGAEAASEAEVVIT 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L + +V Y V+ A G+L ID+STI + + + ALEKG DAPVSG
Sbjct: 64 SLPNGDIVKSCYAE---VLPAAPTGTLFIDTSTISVDDARTVHTQALEKGHAQLDAPVSG 120
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
GV GA TLAFM GG + ER+
Sbjct: 121 GVKGATAGTLAFMVGGEDDAVERA 144
>UniRef50_Q8ES28 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=13;
Bacillaceae|Rep: 3-hydroxyisobutyrate dehydrogenase -
Oceanobacillus iheyensis
Length = 299
Score = 101 bits (242), Expect = 2e-20
Identities = 53/143 (37%), Positives = 80/143 (55%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLGNMG M+ L+ G+ V G+D +++ K+G A S +
Sbjct: 4 IGFIGLGNMGLPMSIGLMNSGYEVIGFDVNEERSLLFKKSGGNIALSSADLVAESDVILT 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L SNK V VYL K G++ H ++ID+ST+ P + +Q+ E+ + F APVSG
Sbjct: 64 SLPSNKAVEAVYLNKGGLLDHCNSSQVVIDTSTVAPELNQQLEASLSERSIPFLAAPVSG 123
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
GV+GA N TL M GG++E F++
Sbjct: 124 GVVGAENQTLTVMVGGKEETFQK 146
>UniRef50_Q0K0E2 Cluster: 3-Hydroxyisobutyrate dehydrogenase; n=1;
Ralstonia eutropha H16|Rep: 3-Hydroxyisobutyrate
dehydrogenase - Ralstonia eutropha (strain ATCC 17699 /
H16 / DSM 428 / Stanier 337)(Cupriavidus necator (strain
ATCC 17699 / H16 / DSM 428 / Stanier337))
Length = 299
Score = 101 bits (242), Expect = 2e-20
Identities = 57/144 (39%), Positives = 78/144 (54%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AF+GLGNMG MA NLV+ G V+G+D S+ AL A G S+ S
Sbjct: 4 IAFIGLGNMGMPMALNLVRAGHDVQGFDISEAALAGFAGQGGQSQRSVAAAVDGASIVIS 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
I+ + V ++Y GV+ A G+LLI+SSTI P + + A + G DAPV+G
Sbjct: 64 IVRNADDVKNLYCTAGGVLDVAAPGALLIESSTIGPAAARAVAAEAAQAGFAMLDAPVAG 123
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
G GA A L FM GG + F+R+
Sbjct: 124 GQAGAREARLTFMVGGARTAFDRA 147
>UniRef50_O34948 Cluster: Uncharacterized oxidoreductase ykwC; n=19;
cellular organisms|Rep: Uncharacterized oxidoreductase
ykwC - Bacillus subtilis
Length = 288
Score = 100 bits (240), Expect = 3e-20
Identities = 53/144 (36%), Positives = 81/144 (56%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
K + F+GLG MG MA++++ G V Y +K+ + + G +++
Sbjct: 3 KTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQKGAIWKDTVKDLSKEADVI 62
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+++ V +VY G +G++ +AK+G+ LID +T P++ K+I A EK L DAPV
Sbjct: 63 ITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSLAKKIAEAAKEKALFALDAPV 122
Query: 506 SGGVMGAXNATLAFMAGGRKEDFE 577
SGG +GA N TLA M GG KE FE
Sbjct: 123 SGGDIGAQNGTLAIMVGGEKEAFE 146
>UniRef50_Q9K9L1 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Bacillus|Rep: 3-hydroxyisobutyrate dehydrogenase -
Bacillus halodurans
Length = 299
Score = 100 bits (239), Expect = 3e-20
Identities = 56/146 (38%), Positives = 74/146 (50%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ V F+GLG MG M +LV KGF S+ + A + G S
Sbjct: 3 QKVGFVGLGTMGLPMTKHLVDKGFETYVKSRSRGPIEEAIQYGAIEVESYKELMETADIV 62
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+ L + V+DVY G+DG++A +G +LID ST+D ++ EKG F DAPV
Sbjct: 63 MTCLPLPETVIDVYEGEDGLIAGLSQGKILIDHSTVDRETNVRVAEQIKEKGGAFLDAPV 122
Query: 506 SGGVMGAXNATLAFMAGGRKEDFERS 583
SGG MGA TL M GG + FERS
Sbjct: 123 SGGPMGAKAGTLTIMCGGEADSFERS 148
>UniRef50_Q41DK0 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Bacillaceae|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Exiguobacterium sibiricum
255-15
Length = 293
Score = 100 bits (239), Expect = 3e-20
Identities = 52/144 (36%), Positives = 83/144 (57%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
K + F+GLG MG M NL+K GF+V+GY+ +K+ ++G ++I
Sbjct: 3 KTIGFIGLGVMGQGMVRNLLKAGFSVKGYNRTKEKGLPLEQDGAVIVDTIQEAVTDVDVV 62
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
SI+ + V ++YL +DG++A A G+++ID +T P + +I A + GL DAPV
Sbjct: 63 ISIVGYPQDVEEIYLAEDGILASANPGTIVIDMTTSSPALAIRIAEQAAQTGLHALDAPV 122
Query: 506 SGGVMGAXNATLAFMAGGRKEDFE 577
+GG +GA N TLA + GG + F+
Sbjct: 123 TGGDLGAKNGTLAILVGGEEAAFD 146
>UniRef50_Q9V8M5 Cluster: Probable 3-hydroxyisobutyrate
dehydrogenase, mitochondrial precursor; n=4;
Diptera|Rep: Probable 3-hydroxyisobutyrate
dehydrogenase, mitochondrial precursor - Drosophila
melanogaster (Fruit fly)
Length = 324
Score = 99 bits (238), Expect = 5e-20
Identities = 60/157 (38%), Positives = 81/157 (51%), Gaps = 2/157 (1%)
Frame = +2
Query: 110 TAARRAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPAN 289
T R + KN+ F+GLGNMG MA+NL+K G + +D SK A + A G T
Sbjct: 17 TLVRAMSTQGGAKNIGFVGLGNMGANMASNLIKAGHKLHVFDISKPACDGLAAKGATVYA 76
Query: 290 SIXXXXXXXXXXXSILTSNKVVLDVY--LGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFP 463
++L +N +V Y + DGV K ++ IDSSTI P++ K +
Sbjct: 77 KTSELAKNSDFVITMLPNNAIVDASYDEMTADGV----NKDTIFIDSSTISPDLVKSLQK 132
Query: 464 IALEKGLGFTDAPVSGGVMGAXNATLAFMAGGRKEDF 574
KG F DAPVSGGV GA ATL FM GG + ++
Sbjct: 133 KISAKGARFIDAPVSGGVPGAEQATLTFMVGGTEAEY 169
>UniRef50_Q83D20 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=9;
Proteobacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Coxiella burnetii
Length = 297
Score = 99.5 bits (237), Expect = 6e-20
Identities = 54/144 (37%), Positives = 78/144 (54%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG+MG M NL+K V+ YD +A+ A K G T A S +
Sbjct: 4 IGFIGLGHMGQPMVNNLIKNNCLVKVYDVIDEAVEKAVKTGATAAASPAEVAEEADVVFT 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L ++ V + L G+ A + ++ IDSS+ID +++ A ++G+ DAPVSG
Sbjct: 64 MLQTSDQVRNCCLSAKGIFATINRQAIYIDSSSIDIEGSRELHKEAKKRGISMLDAPVSG 123
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
GV A A L FM GG KEDFER+
Sbjct: 124 GVAAAEAAGLTFMVGGEKEDFERA 147
>UniRef50_Q9A8J9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=24;
Alphaproteobacteria|Rep: 3-hydroxyisobutyrate
dehydrogenase - Caulobacter crescentus (Caulobacter
vibrioides)
Length = 298
Score = 98.7 bits (235), Expect = 1e-19
Identities = 58/141 (41%), Positives = 75/141 (53%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AF+GLGNMGG MAAN K VR +D S A+ A G A S+ +
Sbjct: 4 IAFIGLGNMGGGMAANQAKAQHQVRAFDLSAAAVERAVAAGCLAAASVAEAVAEAEIVIT 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L + V VY + ++ +A K +LLID STID + + + A E G F DAPVSG
Sbjct: 64 MLPAGPHVRAVYA--EQILPNAPKSALLIDCSTIDVDSARVVARQAAEAGFRFADAPVSG 121
Query: 512 GVMGAXNATLAFMAGGRKEDF 574
G+M A TLAFM G DF
Sbjct: 122 GIMAAEAGTLAFMVGCEASDF 142
>UniRef50_Q1AVA4 Cluster: 2-hydroxy-3-oxopropionate reductase; n=6;
Bacteria|Rep: 2-hydroxy-3-oxopropionate reductase -
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 309
Score = 98.3 bits (234), Expect = 1e-19
Identities = 58/158 (36%), Positives = 85/158 (53%), Gaps = 1/158 (0%)
Frame = +2
Query: 113 AARRAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPS-KDALNAAAKNGVTPAN 289
A R + + V F+GLG MG MA NL++ G+++ ++ + + A A + G A
Sbjct: 4 APRERRKAGMAEKVGFIGLGIMGRPMAENLIRAGYSLTVHNRTHQKAEEFAQQTGARTAK 63
Query: 290 SIXXXXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIA 469
S ++L + V V G+ GV+ ++GSLLID STI P V +Q+ A
Sbjct: 64 SPKEVAGQSDIIITMLPDSPDVESVVAGEGGVLEGMREGSLLIDMSTISPAVARQLAAKA 123
Query: 470 LEKGLGFTDAPVSGGVMGAXNATLAFMAGGRKEDFERS 583
E+G DAPVSGG +GA TL+ M GG +EDF R+
Sbjct: 124 RERGASMLDAPVSGGDVGAREGTLSIMVGGSEEDFGRA 161
>UniRef50_A5V0D4 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=4; Chloroflexaceae|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Roseiflexus sp. RS-1
Length = 303
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/146 (36%), Positives = 78/146 (53%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ V F+GLG MG MA N++K GF +R ++ + ++ A G PA+S
Sbjct: 5 ERVGFIGLGIMGRGMARNILKAGFPLRVWNRTASRMDELAAEGAGPASSPGDLAFHSDII 64
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+ ++ V V LG+ GV+ A+ GSL+ID STI P ++I E+ + DAPV
Sbjct: 65 ITCVSDTPDVEQVLLGEGGVIHGARPGSLVIDMSTISPRATQRIAAHLAERHIHMLDAPV 124
Query: 506 SGGVMGAXNATLAFMAGGRKEDFERS 583
SGG GA TL+ M GG FER+
Sbjct: 125 SGGSEGAARGTLSIMVGGDVTQFERA 150
>UniRef50_A1SIN3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Nocardioides sp. JS614|Rep: 3-hydroxyisobutyrate
dehydrogenase - Nocardioides sp. (strain BAA-499 /
JS614)
Length = 308
Score = 97.5 bits (232), Expect = 2e-19
Identities = 54/150 (36%), Positives = 79/150 (52%), Gaps = 3/150 (2%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ +AF+GLGNMG MA NL+ GF V G+D +A+ G+ A +
Sbjct: 2 ERIAFIGLGNMGNSMAKNLIAAGFDVVGFDADSRTNQRSAETGIPVAADVVDAVTGADVV 61
Query: 326 XSILTSNKVVLDVYLG---KDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 496
++L + ++ V LG + GV+ + G+L+IDSS+ID + A G+ F D
Sbjct: 62 ITMLPNGDILRQVLLGAGAESGVLNYLAPGALVIDSSSIDVANCLAVHESAASAGIAFLD 121
Query: 497 APVSGGVMGAXNATLAFMAGGRKEDFERSF 586
APVSGGV GA TL FM GG + R++
Sbjct: 122 APVSGGVGGAAAGTLTFMVGGDEAHVRRAW 151
>UniRef50_A6LT11 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Clostridiales|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Clostridium beijerinckii
NCIMB 8052
Length = 291
Score = 96.3 bits (229), Expect = 6e-19
Identities = 52/145 (35%), Positives = 81/145 (55%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
K + F+G+G MG M NL+KKG+ V Y +K+ + G + +
Sbjct: 2 KTIGFIGVGVMGKSMVRNLMKKGYEVSIYTRTKEKVLDVINEGAKWCDDVKSCANNRDVI 61
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+I+ K V +VY G++G++ +AKK S +ID +T P + +I+ A ++ + DAPV
Sbjct: 62 ITIVGYPKDVEEVYFGENGILENAKKESCIIDMTTTSPKLSIKIYNEAKKREIYALDAPV 121
Query: 506 SGGVMGAXNATLAFMAGGRKEDFER 580
SGG +GA NATL+ M GG E FE+
Sbjct: 122 SGGDVGAKNATLSIMVGGDLEVFEK 146
>UniRef50_Q22B54 Cluster: 3-hydroxyisobutyrate dehydrogenase family
protein; n=1; Tetrahymena thermophila SB210|Rep:
3-hydroxyisobutyrate dehydrogenase family protein -
Tetrahymena thermophila SB210
Length = 316
Score = 95.9 bits (228), Expect = 7e-19
Identities = 54/143 (37%), Positives = 77/143 (53%), Gaps = 1/143 (0%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKG-FTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXX 322
+ V F+GLGNMGG MA NL +KG F V +D +KD+L AK G+ +
Sbjct: 17 ETVGFIGLGNMGGPMALNLARKGGFEVIAFDVNKDSLKKYAKEGLAVCEDVTVLARKANK 76
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
++L ++ V V G++G+ + K SL IDSSTI + +I+ A + + DAP
Sbjct: 77 FVTMLPNSSHVSSVLEGENGLFQKSAKNSLFIDSSTISYHAAIKIYENAKKVNQRYIDAP 136
Query: 503 VSGGVMGAXNATLAFMAGGRKED 571
VSGGV A TL FM G ++
Sbjct: 137 VSGGVGAATAGTLTFMVGAENKE 159
>UniRef50_Q11FC5 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Rhizobiales|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Mesorhizobium sp. (strain
BNC1)
Length = 292
Score = 95.5 bits (227), Expect = 1e-18
Identities = 55/144 (38%), Positives = 75/144 (52%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AF+G G MG M ANL K GF ++ YD S AL +GVT A+S+ +
Sbjct: 4 LAFIGAGVMGRPMIANLRKAGFALKAYDRSPAALENLRSDGVTVADSLAAAVAGADVVVT 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L V V LG+DG+ G+L+ID STI + + I +G+ DAPVSG
Sbjct: 64 MLPDTPHVQSVLLGEDGIGTLLPTGTLVIDMSTISASGIRAIGQDLASRGVDLVDAPVSG 123
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
GV GA L+ M GG E F ++
Sbjct: 124 GVRGAIAGELSIMCGGSPEAFAKA 147
>UniRef50_A3RRS1 Cluster: 2-hydroxy-3-oxopropionate reductase; n=11;
Betaproteobacteria|Rep: 2-hydroxy-3-oxopropionate
reductase - Ralstonia solanacearum UW551
Length = 298
Score = 95.5 bits (227), Expect = 1e-18
Identities = 59/147 (40%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AF+GLGNMG M +LV G VR Y +A + A G P +S +
Sbjct: 4 IAFIGLGNMGSPMVGHLVAAGHAVRAYVRRPEAADRARALGAEPCDSPADAARDAEVVFT 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKG----SLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 499
+TS V V LG DGV+ A +G ++ ID STI ++I GL F DA
Sbjct: 64 NVTSTADVEAVLLGPDGVIHGAPRGKPGSAVCIDHSTISAVATRRIAAELETAGLDFLDA 123
Query: 500 PVSGGVMGAXNATLAFMAGGRKEDFER 580
PVSGG MGA ATL+ M GG+ E ER
Sbjct: 124 PVSGGTMGAQKATLSIMVGGKAEVLER 150
>UniRef50_Q930C6 Cluster: Probable; n=8; Alphaproteobacteria|Rep:
Probable - Rhizobium meliloti (Sinorhizobium meliloti)
Length = 295
Score = 95.1 bits (226), Expect = 1e-18
Identities = 53/140 (37%), Positives = 70/140 (50%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
VA +G G MGG + A LV+ G + +DP D + A G A S
Sbjct: 5 VALIGAGAMGGSIGARLVETGNRLTVFDPGPDKVQALVDKGAFAAPSAAEAAAVSDYVIL 64
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L + +V G GV A A+ G+L+ID S+IDPN KQ+ A EKGL + D+P+SG
Sbjct: 65 SLNAPAIVRQAVFGDAGVAAGAQAGTLIIDMSSIDPNATKQLAADAAEKGLRWVDSPLSG 124
Query: 512 GVMGAXNATLAFMAGGRKED 571
G A L MAGG +D
Sbjct: 125 GAPKALIGELTLMAGGTAQD 144
>UniRef50_A2SP40 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Methylibium petroleiphilum PM1|Rep: 3-hydroxyisobutyrate
dehydrogenase - Methylibium petroleiphilum (strain PM1)
Length = 297
Score = 95.1 bits (226), Expect = 1e-18
Identities = 53/141 (37%), Positives = 74/141 (52%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
K + +GLGN+GG M L+ +G V G+D S A AAA++G S
Sbjct: 2 KEIGLIGLGNIGGGMCRRLLDRGIGVVGFDLSPAATKAAAEHGARIEVSPAAVAQQVDVV 61
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+ L + +V DVYLGK G+VA A+ GS LI++STIDPN +++ A + G+ D +
Sbjct: 62 VTSLPNPPIVRDVYLGKQGLVAQARPGSTLIETSTIDPNTIREVAQAATKSGIRILDIAL 121
Query: 506 SGGVMGAXNATLAFMAGGRKE 568
SG A L F GG E
Sbjct: 122 SGEPPQAVLGELVFQVGGPDE 142
>UniRef50_Q8KL12 Cluster: Probable 6-phosphogluconate dehydrogenase
protein; n=1; Rhizobium etli CFN 42|Rep: Probable
6-phosphogluconate dehydrogenase protein - Rhizobium
etli (strain CFN 42 / ATCC 51251)
Length = 294
Score = 94.7 bits (225), Expect = 2e-18
Identities = 55/151 (36%), Positives = 79/151 (52%)
Frame = +2
Query: 131 SSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXX 310
S + VAF+GLG MGG MA +L+ F V G+D S +A A G PA ++
Sbjct: 2 SPRKNLRVAFIGLGAMGGPMAQHLLSAQFEVTGFDLSAEARERFAAVGGVPAETVAEAFN 61
Query: 311 XXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGF 490
++L + K+V D L KDG +L+ID S+ PN +++ +KGL
Sbjct: 62 GADVAVTMLPNGKIVQDA-LFKDGAWQSLSADALVIDMSSSAPNDTRELAERLHQKGLRL 120
Query: 491 TDAPVSGGVMGAXNATLAFMAGGRKEDFERS 583
DAPVSGGV A +L MAGG +D +++
Sbjct: 121 VDAPVSGGVKRAVEGSLTIMAGGASDDIDQA 151
>UniRef50_Q1V2R0 Cluster: MmsB-like protein; n=2; Candidatus
Pelagibacter ubique|Rep: MmsB-like protein - Candidatus
Pelagibacter ubique HTCC1002
Length = 308
Score = 94.7 bits (225), Expect = 2e-18
Identities = 51/140 (36%), Positives = 76/140 (54%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
++AF+G+GNMG MA LVK G V+ +D S + + A ++G+ ++I
Sbjct: 4 HIAFIGVGNMGNPMADQLVKAGKEVKAFDVSPEVIKIAKESGLNVVSTIDELLDGASTVI 63
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
S+L K V +YLG G++ K L+ID STID ++ + + G+ DAPV+
Sbjct: 64 SMLPEGKHVRSLYLGDKGILNKIPKECLIIDCSTIDIETSLELGNESKKLGIKMIDAPVT 123
Query: 509 GGVMGAXNATLAFMAGGRKE 568
GGVMGA L F+ GG E
Sbjct: 124 GGVMGARIGKLNFLVGGSDE 143
>UniRef50_Q55702 Cluster: Uncharacterized oxidoreductase slr0229;
n=4; Cyanobacteria|Rep: Uncharacterized oxidoreductase
slr0229 - Synechocystis sp. (strain PCC 6803)
Length = 290
Score = 94.3 bits (224), Expect = 2e-18
Identities = 55/146 (37%), Positives = 75/146 (51%), Gaps = 2/146 (1%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPS--KDALNAAAKNGVTPANSIXXXXXXXXXX 325
+A GLG MG MA NLVK G+ GY+ + + ++ AAK GV SI
Sbjct: 6 IAVFGLGVMGSPMAQNLVKNGYQTVGYNRTLERPSVQEAAKAGVKVVTSIAVAAANADII 65
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+ + K V + LG G+ +AK +L+ID STI ++ +GL F DAPV
Sbjct: 66 LTCVGDEKDVQQLILGSGGIAEYAKPQALIIDCSTIGKTAAYELATNLKLQGLRFLDAPV 125
Query: 506 SGGVMGAXNATLAFMAGGRKEDFERS 583
+GG +GA N TL M GG DFE +
Sbjct: 126 TGGDVGAINGTLTIMVGGDISDFEEA 151
>UniRef50_A3SJ77 Cluster: Probable oxidoreductase; n=1; Roseovarius
nubinhibens ISM|Rep: Probable oxidoreductase -
Roseovarius nubinhibens ISM
Length = 320
Score = 93.9 bits (223), Expect = 3e-18
Identities = 57/143 (39%), Positives = 68/143 (47%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ VAF+GLG MG MAA LV G VRG D L A + G PA S+
Sbjct: 12 RRVAFIGLGTMGSGMAARLVAAGHEVRGVDIDSARLAAFEEVGGLPAASVAEACDGAEII 71
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+IL + V + LG G+ A G+L+I+ STI P I KGL DAPV
Sbjct: 72 MTILPRDTHVRQICLGAGGIADSAAPGTLVIEMSTISPEASLDIHDALTSKGLRVLDAPV 131
Query: 506 SGGVMGAXNATLAFMAGGRKEDF 574
A N L MAGGR EDF
Sbjct: 132 GRTPKDAQNGALLIMAGGRAEDF 154
>UniRef50_A6NVP0 Cluster: Putative uncharacterized protein; n=1;
Bacteroides capillosus ATCC 29799|Rep: Putative
uncharacterized protein - Bacteroides capillosus ATCC
29799
Length = 306
Score = 93.5 bits (222), Expect = 4e-18
Identities = 51/143 (35%), Positives = 72/143 (50%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG MG MA NL+ G+ V +D + A+ G S
Sbjct: 8 IGFIGLGAMGRPMATNLLTAGYEVHAFDVVEAAVKEMEGKGAIGHPSAGEMAGHVDVIIC 67
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L + K+V GK+GV + K+G+++ID S++ PN K + A EKG+ + DAPVSG
Sbjct: 68 SLPNAKIVEGTMCGKNGVFENCKEGTVIIDMSSVAPNTTKAMAKKAAEKGIHYIDAPVSG 127
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
GV GA TL M G E F +
Sbjct: 128 GVSGAAAGTLTIMVGADDETFNK 150
>UniRef50_A4IN46 Cluster: 3-hydroxyisobutyrate dehydrogenase-like
protein; n=2; Geobacillus|Rep: 3-hydroxyisobutyrate
dehydrogenase-like protein - Geobacillus
thermodenitrificans (strain NG80-2)
Length = 304
Score = 93.1 bits (221), Expect = 5e-18
Identities = 49/144 (34%), Positives = 77/144 (53%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
NV F+GLG MG MA L+ GF V Y+ + + ++G A +I
Sbjct: 3 NVGFIGLGMMGSRMAKRLLDAGFPVTVYNRTPEKAAILVESGARQAETIAALASEVDVIC 62
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
+ L+ V++VY G+ GV++ A++G + +D +T+ P + + A E+G+ + DAPVS
Sbjct: 63 TCLSMPDDVINVYTGEGGVLSAARRGVICLDFTTVGPKTSRFVAGRAGERGVAYLDAPVS 122
Query: 509 GGVMGAXNATLAFMAGGRKEDFER 580
GG GA TL M GG + +ER
Sbjct: 123 GGPEGAEQGTLTIMVGGDQAAWER 146
>UniRef50_Q92D17 Cluster: Lin1004 protein; n=10; Bacilli|Rep:
Lin1004 protein - Listeria innocua
Length = 286
Score = 92.7 bits (220), Expect = 7e-18
Identities = 51/143 (35%), Positives = 76/143 (53%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ + F+G G MG MA +L++ G+ V Y +K+ A G +
Sbjct: 2 EKIGFVGTGVMGSSMAKHLLEAGYEVHIYTRTKEKAEALLSQGALWESDPGSLGAKVDIL 61
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
S++ K V +YLG++G + + K GS+ ID +T P + K+I EKG+G DAPV
Sbjct: 62 ISMVGYPKDVEQLYLGENGFLDNLKAGSVAIDMTTSSPALAKKIAEAGHEKGIGVLDAPV 121
Query: 506 SGGVMGAXNATLAFMAGGRKEDF 574
SGG +GA N TLA M GG ++ F
Sbjct: 122 SGGDIGAKNGTLAIMVGGAEDVF 144
>UniRef50_A6P2M7 Cluster: Putative uncharacterized protein; n=2;
Bacteria|Rep: Putative uncharacterized protein -
Bacteroides capillosus ATCC 29799
Length = 321
Score = 92.3 bits (219), Expect = 9e-18
Identities = 48/142 (33%), Positives = 78/142 (54%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AF+G+G MG M NL+K G+++ Y +K G A+++ S
Sbjct: 38 IAFIGVGIMGKSMVRNLMKAGYSLTIYSRTKAKCEDVIAEGAVWADTVADCVRDAEAVFS 97
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
I+ K V +VY G G++++A+ G+L++D +T P + ++I+ KGL DAPV+G
Sbjct: 98 IVGYPKDVEEVYFGDGGIISNAQPGALIVDMTTSSPALAERIWEAGKAKGLRPLDAPVTG 157
Query: 512 GVMGAXNATLAFMAGGRKEDFE 577
G GA TL+ + GG K DF+
Sbjct: 158 GDTGAKAGTLSILVGGDKVDFD 179
>UniRef50_Q97XZ7 Cluster: Oxidoreductase; n=6; Thermoprotei|Rep:
Oxidoreductase - Sulfolobus solfataricus
Length = 289
Score = 91.9 bits (218), Expect = 1e-17
Identities = 51/143 (35%), Positives = 76/143 (53%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V F+GLG MG MA+NL+K G+ + Y+ + + K G A+S S
Sbjct: 3 VGFIGLGIMGFPMASNLLKAGYDLTVYNRTIEKAEKLGKMGAKVAHSPKEVAEVSEIVIS 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
++T V +V G++GVV K+G + +D ST P K++ E G+ F DAPV+G
Sbjct: 63 MVTDAPDVEEVLFGENGVVKSNKRGLIFVDMSTNSPEFAKKVTKRLSEYGMEFLDAPVTG 122
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
G GA TL M GG+++ F+R
Sbjct: 123 GDKGAREGTLTIMVGGKEDVFKR 145
>UniRef50_Q5L168 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=15;
Bacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Geobacillus kaustophilus
Length = 288
Score = 90.2 bits (214), Expect = 4e-17
Identities = 45/143 (31%), Positives = 76/143 (53%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
K + F+GLG MG MA +L+K G+ + Y +K+ + G ++
Sbjct: 2 KTIGFIGLGVMGKSMARHLLKAGYPLLAYTRTKEKAEDLLQEGAVWKETVADLAREADVV 61
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+++ + V VY G+ G++ +A+ G+ +ID +T P + + I+ A +KG+ DAPV
Sbjct: 62 MTMVGDPRDVEQVYFGEGGILENARPGTYVIDMTTSTPTLAQSIYEAAKQKGIHALDAPV 121
Query: 506 SGGVMGAXNATLAFMAGGRKEDF 574
SGG +GA TL M GG ++ F
Sbjct: 122 SGGDIGAREGTLTIMVGGDEDVF 144
>UniRef50_Q4ZQL5 Cluster: 3-hydroxyisobutyrate dehydrogenase
precursor; n=11; Proteobacteria|Rep:
3-hydroxyisobutyrate dehydrogenase precursor -
Pseudomonas syringae pv. syringae (strain B728a)
Length = 296
Score = 89.8 bits (213), Expect = 5e-17
Identities = 49/141 (34%), Positives = 71/141 (50%)
Frame = +2
Query: 161 LGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXSILT 340
+GLGNMGG MAA L KGF V G+D S+ AL A GV P L
Sbjct: 8 IGLGNMGGGMAATLAGKGFDVSGFDLSQAALAQAESKGVKPVADRTQLIQGVDILILSLP 67
Query: 341 SNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVM 520
+ V V LG G+ +KG +++D++T P + +++ + G+ F DAPVSGG
Sbjct: 68 KAEHVESVCLGAGGINEVGRKGLIVVDTTTSTPEMSRKVAAELAKNGIAFIDAPVSGGPK 127
Query: 521 GAXNATLAFMAGGRKEDFERS 583
GA +++ + G D R+
Sbjct: 128 GAATGSMSMVIGAEDADLARA 148
>UniRef50_Q1QWQ5 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=4; Proteobacteria|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Chromohalobacter salexigens
(strain DSM 3043 / ATCC BAA-138 / NCIMB13768)
Length = 315
Score = 89.8 bits (213), Expect = 5e-17
Identities = 53/157 (33%), Positives = 77/157 (49%)
Frame = +2
Query: 110 TAARRAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPAN 289
T AR + +G G MG MA L + G+ VR ++ S D A +G+ A+
Sbjct: 13 TTAREDRDMQDTTTIGVIGTGLMGAPMARRLAEAGYAVRAWNRSNDKARALTAHGIDIAD 72
Query: 290 SIXXXXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIA 469
S +L+S V D+ LG +GV+AH + L+ S+I + ++ A
Sbjct: 73 SPRDAAGADIVVV-MLSSGPVCDDILLGPEGVIAHMAPHATLVVMSSIPVDTAQRQAQAA 131
Query: 470 LEKGLGFTDAPVSGGVMGAXNATLAFMAGGRKEDFER 580
+G+G+ DAPVSGG GA + TLA M GG FER
Sbjct: 132 EARGIGYLDAPVSGGERGAIDGTLAIMVGGDPATFER 168
>UniRef50_A6GTB5 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding protein; n=1; Limnobacter sp. MED105|Rep:
6-phosphogluconate dehydrogenase, NAD-binding protein -
Limnobacter sp. MED105
Length = 299
Score = 89.8 bits (213), Expect = 5e-17
Identities = 51/147 (34%), Positives = 70/147 (47%)
Frame = +2
Query: 140 TDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXX 319
T + F+GLGNMG MA +L K G+TV + + A A + P SI
Sbjct: 7 TLNTIGFIGLGNMGAAMAGHLCKAGYTVLAWARNASTFEALADIPLVPQPSIEALCASTR 66
Query: 320 XXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 499
+T+ V + G+ HA+ GS+++D STID I +G+ + D
Sbjct: 67 LVALNVTNTADVQSLLFRDGGIAQHAQPGSIIVDFSTIDAAAVADIARQLKSRGVDYIDC 126
Query: 500 PVSGGVMGAXNATLAFMAGGRKEDFER 580
PVSGG GA ATL+ MAGG F R
Sbjct: 127 PVSGGAAGARAATLSMMAGGDLAAFNR 153
>UniRef50_Q0QLF5 Cluster: 2-hydroxymethyl glutarate dehydrogenase;
n=1; Eubacterium barkeri|Rep: 2-hydroxymethyl glutarate
dehydrogenase - Eubacterium barkeri (Clostridium
barkeri)
Length = 301
Score = 89.4 bits (212), Expect = 7e-17
Identities = 47/143 (32%), Positives = 74/143 (51%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG MG MA NL+K+G TV +D + + A G + +
Sbjct: 7 IGFIGLGAMGKPMAINLLKEGVTVYAFDLMEANVAAVVAQGAQACENNQKVAAASDIIFT 66
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L + +V V G GV++ K G++++D S++ P+ ++ +A EKG+ + DAPVSG
Sbjct: 67 SLPNAGIVETVMNGPGGVLSACKAGTVIVDMSSVSPSSTLKMAKVAAEKGIDYVDAPVSG 126
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
G GA TL M G + FE+
Sbjct: 127 GTKGAEAGTLTIMVGASEAVFEK 149
>UniRef50_Q58PL4 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
uncultured proteobacterium DelRiverFos06H03|Rep:
3-hydroxyisobutyrate dehydrogenase - uncultured
proteobacterium DelRiverFos06H03
Length = 299
Score = 89.0 bits (211), Expect = 9e-17
Identities = 50/141 (35%), Positives = 74/141 (52%)
Frame = +2
Query: 158 FLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXSIL 337
F+G+GNMG MAANLVK G+ V +D S+ G T S+ + L
Sbjct: 10 FIGVGNMGNPMAANLVKAGYPVTVFDVSRAKAENLIALGATWVGSLAEGAVNADVVMASL 69
Query: 338 TSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGV 517
V +V LG+ GV+AH K G+ +ID+ST + +++ +A KG+ F +APV+ V
Sbjct: 70 PGPVQVREVMLGEQGVLAHVKAGATVIDTSTSAVELVQELVALAKSKGVDFLEAPVTNAV 129
Query: 518 MGAXNATLAFMAGGRKEDFER 580
A L+ GG K+ FE+
Sbjct: 130 DMAALGRLSIFVGGDKDCFEK 150
>UniRef50_Q01ZG6 Cluster: 2-hydroxy-3-oxopropionate reductase; n=6;
Bacteria|Rep: 2-hydroxy-3-oxopropionate reductase -
Solibacter usitatus (strain Ellin6076)
Length = 298
Score = 89.0 bits (211), Expect = 9e-17
Identities = 50/144 (34%), Positives = 74/144 (51%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
++ F+GLG MG M+ NL+K G+++ YD + + G S
Sbjct: 3 DIGFIGLGIMGKPMSRNLMKAGYSLVVYDIFPGPVAELKEAGAGAGASCAATAAAAPIVI 62
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
++L V LG GV+ AK G++++D S+I P V +++ KG+ F DAPVS
Sbjct: 63 TMLPDGPEVETAVLGPGGVLEGAKAGTVVVDMSSISPMVSQKVAAACAAKGVEFLDAPVS 122
Query: 509 GGVMGAXNATLAFMAGGRKEDFER 580
GG A + TLA M GG+ E FER
Sbjct: 123 GGEPKAIDGTLAIMVGGKPEVFER 146
>UniRef50_Q183P5 Cluster: 2-hydroxy-3-oxopropionate reductase; n=5;
Bacteria|Rep: 2-hydroxy-3-oxopropionate reductase -
Clostridium difficile (strain 630)
Length = 296
Score = 88.6 bits (210), Expect = 1e-16
Identities = 51/143 (35%), Positives = 78/143 (54%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG MG MA NL+K G + YD +K A++ G A S+ +
Sbjct: 3 LGFIGLGIMGKPMAKNLLKDGCNLLVYDINKSAVDELISCGAKYA-SVLEMGQECDIVFT 61
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
IL + +V D+ G DG+ K+GS+++D S++ P + GL F D+PVSG
Sbjct: 62 ILPNGTIVQDILFGMDGLAKTLKEGSIVVDMSSVTPTESILCANKLKDMGLEFIDSPVSG 121
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
G A + TLAFMAGG++E +++
Sbjct: 122 GEPKAIDGTLAFMAGGKEEIYKK 144
>UniRef50_Q1QWU9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Chromohalobacter salexigens DSM 3043|Rep:
3-hydroxyisobutyrate dehydrogenase - Chromohalobacter
salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB13768)
Length = 310
Score = 88.2 bits (209), Expect = 2e-16
Identities = 53/146 (36%), Positives = 75/146 (51%)
Frame = +2
Query: 143 DKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXX 322
D N+ +GLG MGG MA L GFTV G D + A + A G++ +
Sbjct: 10 DMNIVVIGLGQMGGNMAMTLHAAGFTVTGTDVADAARDNLAARGLS-VTRLDALPEADVY 68
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
S+ TS V +V G++ A KGS+++D+ST DP V +++ +E GL + DAP
Sbjct: 69 LLSLPTSAHV-REVIETSPGLLQRAPKGSVIVDTSTSDPAVTRELAGKVVEAGLEWLDAP 127
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFER 580
VSGG GA + L + GG ER
Sbjct: 128 VSGGPAGAASGALGMLLGGESATIER 153
>UniRef50_A6SW62 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Janthinobacterium sp. Marseille|Rep:
3-hydroxyisobutyrate dehydrogenase - Janthinobacterium
sp. (strain Marseille) (Minibacterium massiliensis)
Length = 298
Score = 88.2 bits (209), Expect = 2e-16
Identities = 53/146 (36%), Positives = 73/146 (50%), Gaps = 1/146 (0%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNA-AAKNGVTPANSIXXXXXXXXX 322
+N+ F+G+GNMG MA L +KGF++ YD NA A ++G A S
Sbjct: 5 RNIGFIGIGNMGAPMAGQLARKGFSLTVYDTHATTANAFAQEHGARVARSAAEVGIGADA 64
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
+L S++VV V L DG+ GS+ ID T P V + I G+G+ DAP
Sbjct: 65 VIFMLPSDQVVRQV-LFTDGLATQLAPGSIAIDMGTSAPAVTRSISAELATLGIGYLDAP 123
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFER 580
V GGV+ A +A+L M G ER
Sbjct: 124 VMGGVVFAKDASLDIMVSGDDASIER 149
>UniRef50_Q03UI4 Cluster: 3-hydroxyisobutyrate dehydrogenase related
enzyme; n=2; Lactobacillales|Rep: 3-hydroxyisobutyrate
dehydrogenase related enzyme - Leuconostoc mesenteroides
subsp. mesenteroides (strain ATCC 8293 /NCDO 523)
Length = 287
Score = 87.8 bits (208), Expect = 2e-16
Identities = 46/140 (32%), Positives = 74/140 (52%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
N+ F+G G MG + NL++ G+ V ++ + N NG ++
Sbjct: 2 NIGFIGTGVMGTGIINNLLQAGYEVSVFNRTHSKANTVLNNGAIWRDTPAKVAQYSDITF 61
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
+++ K V +V+ +DGV A AK+GS+L+D +T P + +Q+ + G DAPVS
Sbjct: 62 TMVGYPKDVEEVWTSEDGVFAGAKEGSILVDMTTSTPRLAEQLAQTGADLGFKVLDAPVS 121
Query: 509 GGVMGAXNATLAFMAGGRKE 568
GG +GA N TLA M GG ++
Sbjct: 122 GGDIGAKNGTLAIMVGGEQQ 141
>UniRef50_P0ABQ3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=25;
Bacteria|Rep: 2-hydroxy-3-oxopropionate reductase -
Escherichia coli O6
Length = 294
Score = 87.4 bits (207), Expect = 3e-16
Identities = 49/145 (33%), Positives = 80/145 (55%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V F+GLG MG M+ NL+K G+++ D + +A+ G A++ +
Sbjct: 3 VGFIGLGIMGKPMSKNLLKAGYSLVVADRNPEAIADVIAAGAETASTAKAIAEQCDVIIT 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L ++ V +V LG++G++ AK G++LID S+I P ++I KG+ DAPVSG
Sbjct: 63 MLPNSPHVKEVALGENGIIEGAKPGTVLIDMSSIAPLASREISEALKAKGIDMLDAPVSG 122
Query: 512 GVMGAXNATLAFMAGGRKEDFERSF 586
G A + TL+ M GG K F++ +
Sbjct: 123 GEPKAIDGTLSVMVGGDKAIFDKYY 147
>UniRef50_Q9SUC0 Cluster: Probable 3-hydroxyisobutyrate
dehydrogenase, mitochondrial precursor; n=13;
Magnoliophyta|Rep: Probable 3-hydroxyisobutyrate
dehydrogenase, mitochondrial precursor - Arabidopsis
thaliana (Mouse-ear cress)
Length = 347
Score = 87.0 bits (206), Expect = 3e-16
Identities = 55/169 (32%), Positives = 86/169 (50%), Gaps = 12/169 (7%)
Frame = +2
Query: 104 LYTAARRAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTP 283
L+ + + +SN +NV F+GLGNMG M NL++ G+ V +D ++D + + GV+
Sbjct: 24 LHRFSSSSQNSNQFQNVGFIGLGNMGFRMVNNLIRAGYKVTVHDINRDVMKMFTEMGVSS 83
Query: 284 ANSIXXXXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAK--KGSLLIDSSTIDPNVPKQI 457
+ ++L S+ V+DVY G +G++ + +L IDSSTIDP ++I
Sbjct: 84 RETPYEVAQDSEVVITMLPSSSHVMDVYTGTNGLLLGENDIRPALFIDSSTIDPQTTRKI 143
Query: 458 FPIALEKGLG----------FTDAPVSGGVMGAXNATLAFMAGGRKEDF 574
L DAPVSGGV+ A TL FM GG ++ +
Sbjct: 144 SLAVSNCNLKEKRDNWEKPVMLDAPVSGGVLAAEAGTLTFMVGGPEDAY 192
>UniRef50_A0K0Z6 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=2; Micrococcineae|Rep:
6-phosphogluconate dehydrogenase, NAD-binding precursor
- Arthrobacter sp. (strain FB24)
Length = 301
Score = 85.4 bits (202), Expect = 1e-15
Identities = 54/143 (37%), Positives = 75/143 (52%), Gaps = 2/143 (1%)
Frame = +2
Query: 137 NTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXX 316
NT +A +GLG MGG MAA L K G+ V G+DPS+ A AAA+ G+ S+
Sbjct: 2 NTSTRIAVIGLGAMGGAMAATLHKAGWDVTGFDPSEAARTAAAQTGIATTASLDDVAGTP 61
Query: 317 XXXXSILTSNKVVLDV--YLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGF 490
S+ ++ V V L G VA +ID++T +P KQ+ +A +G F
Sbjct: 62 YAVLSLPAASIVETTVPRLLAVPGTVA-------IIDTTTSEPATSKQMAHLADTQGAAF 114
Query: 491 TDAPVSGGVMGAXNATLAFMAGG 559
DAPVSGG GA + +L+ GG
Sbjct: 115 VDAPVSGGRDGAASGSLSAFVGG 137
>UniRef50_Q8UBW3 Cluster: Oxidoredutase; n=1; Agrobacterium
tumefaciens str. C58|Rep: Oxidoredutase - Agrobacterium
tumefaciens (strain C58 / ATCC 33970)
Length = 300
Score = 84.6 bits (200), Expect = 2e-15
Identities = 52/138 (37%), Positives = 74/138 (53%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
++VAF+G G MGG MA L+ GF+V+ ++ S D A +G A S
Sbjct: 10 RSVAFIGTGLMGGPMARRLLGTGFSVKVWNRSVDKAQALVADGAVLAASPAEAARGADIV 69
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
++L+ V +V L + GV KG+++IDSS+I P + ++ G+ DAPV
Sbjct: 70 ITMLSDGNAVGEV-LFEAGVAEALAKGAVVIDSSSIAPPIAREHSSRLQAMGIHHVDAPV 128
Query: 506 SGGVMGAXNATLAFMAGG 559
SGGV GA TLA MAGG
Sbjct: 129 SGGVPGATAGTLAIMAGG 146
>UniRef50_A1UP64 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Mycobacterium|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Mycobacterium sp. (strain
KMS)
Length = 305
Score = 83.8 bits (198), Expect = 3e-15
Identities = 52/145 (35%), Positives = 70/145 (48%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
NV F+GLG MG MA +LV G V ++ S+ ++ G A S
Sbjct: 2 NVGFIGLGVMGKPMAGHLVDAGHHVVVFNRSRAKVDELEARGAVGATSPAHAGEKADVVI 61
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
++L + V +V G GV + GSL+ID STI P+ I EK + F DAPVS
Sbjct: 62 TMLPDSPEVEEVLFGPAGVTTTLRPGSLVIDCSTISPDAAVAIGARLAEKDIAFVDAPVS 121
Query: 509 GGVMGAXNATLAFMAGGRKEDFERS 583
GG GA LA M GG ++ R+
Sbjct: 122 GGEAGAIAGALAVMMGGDEDAVRRA 146
>UniRef50_Q5WBB8 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Bacillus clausii KSM-K16|Rep: 3-hydroxyisobutyrate
dehydrogenase - Bacillus clausii (strain KSM-K16)
Length = 283
Score = 83.4 bits (197), Expect = 4e-15
Identities = 48/143 (33%), Positives = 63/143 (44%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
K V +G G MG MA +L+ G+TV YD K G +
Sbjct: 2 KTVGLIGCGAMGKGMATSLLSAGYTVYIYDDMSKWREPLEKQGACFVENSAAVAKKAKYV 61
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
L S +V D GK+GV+ H + G L+D ST D + A KG+ + D PV
Sbjct: 62 LLSLPSPNIVADTVAGKEGVLCHLQTGGFLLDLSTTDVQTTLAMEKAAAAKGIYYLDCPV 121
Query: 506 SGGVMGAXNATLAFMAGGRKEDF 574
SGG GA TL M GG K+ +
Sbjct: 122 SGGPAGADAGTLTIMVGGDKQAY 144
>UniRef50_Q9L7S0 Cluster: Uncharacterized oxidoreductase yihU; n=24;
Gammaproteobacteria|Rep: Uncharacterized oxidoreductase
yihU - Salmonella typhimurium
Length = 298
Score = 83.0 bits (196), Expect = 6e-15
Identities = 46/144 (31%), Positives = 68/144 (47%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AF+GLG MG MA+NL+K+G + +D + DA+ G PA+S +
Sbjct: 4 IAFIGLGQMGSPMASNLLKQGHQLSVFDVNPDAVQRLVDKGAQPASSPAQATIGAEFVIT 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L + +V V G+ GV + +L+ID STI P + KG D P+
Sbjct: 64 MLPNGDLVRSVLFGEQGVCETLSREALVIDMSTIHPLQTDNLIADMQSKGFSMMDVPIGR 123
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
A TL +AGG E ER+
Sbjct: 124 TSDNAITGTLLLLAGGTAEQVERA 147
>UniRef50_Q89UN2 Cluster: Bll1384 protein; n=9; Bacteria|Rep:
Bll1384 protein - Bradyrhizobium japonicum
Length = 356
Score = 82.6 bits (195), Expect = 7e-15
Identities = 48/157 (30%), Positives = 77/157 (49%)
Frame = +2
Query: 107 YTAARRAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPA 286
++ +R ++ ++ F+GLGNMG MA L++ G + +D K+ ++ G TPA
Sbjct: 42 FSRQQRIINTRNTMDIGFIGLGNMGFPMARRLIEAGNRLVVFDTRKEVVDKLVARGATPA 101
Query: 287 NSIXXXXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPI 466
S + L S + L+V G +GV+ + ID ST+ + +I +
Sbjct: 102 TSPKDVADQVETVMASLPSLQASLEVATGTNGVI-EGSRVKRFIDLSTVGSTMASKIHGL 160
Query: 467 ALEKGLGFTDAPVSGGVMGAXNATLAFMAGGRKEDFE 577
++ + D PVSGGV GA TLA M G K +FE
Sbjct: 161 LAKRDIVQIDCPVSGGVGGAEKGTLAVMVSGPKAEFE 197
>UniRef50_Q2JEV5 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=6; Bacteria|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Frankia sp. (strain CcI3)
Length = 302
Score = 82.6 bits (195), Expect = 7e-15
Identities = 49/145 (33%), Positives = 75/145 (51%), Gaps = 1/145 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYD-PSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
VAF+GLG MG MA +LV+ GF+ ++ + A A ++ A S
Sbjct: 3 VAFVGLGTMGFPMAGHLVRAGFSTTAFNRTAATAARWAEEHSGRIAPSPAAAATEVDVVC 62
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
+ ++ V +V LG DGV+ + G++++D +T + ++I E G+GF DAPVS
Sbjct: 63 LCVGADDDVREVVLGADGVLGALRPGAIIVDHTTTSAELAEEIAARTAEVGVGFVDAPVS 122
Query: 509 GGVMGAXNATLAFMAGGRKEDFERS 583
GG GA L+ M GG E ER+
Sbjct: 123 GGEAGAMAGRLSIMCGGDPETIERA 147
>UniRef50_A0GVR3 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Burkholderia phytofirmans PsJN|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Burkholderia phytofirmans PsJN
Length = 311
Score = 82.2 bits (194), Expect = 1e-14
Identities = 47/142 (33%), Positives = 72/142 (50%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+G G MG M +NL+K V D ++DA + A G T A ++ +
Sbjct: 3 IGFIGAGRMGHRMISNLLKGSHAVLVLDGARDARDRVASLGATLAMNLADLVTGQDIVIT 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L + V L VY G G+ + +LL++ ST+D +++ A G DAP++G
Sbjct: 63 MLPTPDVSLSVYEGAGGLFSITPPETLLLECSTVDVKTIERLGEGARASGTQLIDAPLTG 122
Query: 512 GVMGAXNATLAFMAGGRKEDFE 577
G+ GA ATL FM GG +E E
Sbjct: 123 GIEGAALATLTFMVGGSEEQLE 144
>UniRef50_Q89R44 Cluster: Oxidoreductase; n=23; Bacteria|Rep:
Oxidoreductase - Bradyrhizobium japonicum
Length = 305
Score = 81.4 bits (192), Expect = 2e-14
Identities = 45/151 (29%), Positives = 74/151 (49%)
Frame = +2
Query: 131 SSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXX 310
S++ ++ +A +GLG+MG MA +L + G V G D S DA+ K+G A +
Sbjct: 4 STSQNQRIAVVGLGSMGFGMATSLKRAGHAVTGCDVSADAVARFVKDGGAGAKTPAEAAR 63
Query: 311 XXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGF 490
S++ + + GKDGV K S+ + S+T+DP+V +++ G +
Sbjct: 64 GADVVVSVVVNAAQTETILFGKDGVAETMPKDSVFLSSATMDPDVARRLAKQLEATGRHY 123
Query: 491 TDAPVSGGVMGAXNATLAFMAGGRKEDFERS 583
DAP+SGG A L +A G F ++
Sbjct: 124 LDAPISGGAQRAAQGELTILASGSPAAFAKA 154
>UniRef50_Q1YHQ4 Cluster: Putative 2-hydroxy-3-oxopropionate
reductase; n=1; Aurantimonas sp. SI85-9A1|Rep: Putative
2-hydroxy-3-oxopropionate reductase - Aurantimonas sp.
SI85-9A1
Length = 292
Score = 81.4 bits (192), Expect = 2e-14
Identities = 51/143 (35%), Positives = 69/143 (48%), Gaps = 1/143 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG MG L + + V G+D + ++AAA GV PA S+
Sbjct: 4 IGFIGLGLMGSGFTKRLRELDYRVIGHDREAEKVSAAAAWGVEPAGSLAALCAEADIIAL 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAK-KGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
LT++ V V G DG+VA K G ++D ST + V Q+ G F DAPVS
Sbjct: 64 CLTTSDAVASVVTGADGLVASRKLSGRTVVDFSTTEMAVTHQVAAAIEAVGGRFVDAPVS 123
Query: 509 GGVMGAXNATLAFMAGGRKEDFE 577
GG A TLA M GG ++ E
Sbjct: 124 GGPGAAETGTLAIMFGGSEQAAE 146
>UniRef50_Q0S5S3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Rhodococcus sp. RHA1|Rep: 3-hydroxyisobutyrate
dehydrogenase - Rhodococcus sp. (strain RHA1)
Length = 299
Score = 81.4 bits (192), Expect = 2e-14
Identities = 51/136 (37%), Positives = 69/136 (50%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V F+GLGN+GG + A+LVK G V YD + A++AA G S
Sbjct: 5 VGFVGLGNIGGRVVAHLVKAGHDVAVYDLNTAAVDAAVALGARSVASPGEAARKAEALFL 64
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L + +V V V+ +G +++D STIDP+ +++ A G F DAPVSG
Sbjct: 65 SLPTPAIVEGVVAD---VLQQGNQGLVIVDHSTIDPDTTRRLAQDAQVAGACFLDAPVSG 121
Query: 512 GVMGAXNATLAFMAGG 559
GV GA TLA M GG
Sbjct: 122 GVQGAEAGTLAVMLGG 137
>UniRef50_A6SUL3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=1;
Janthinobacterium sp. Marseille|Rep:
2-hydroxy-3-oxopropionate reductase - Janthinobacterium
sp. (strain Marseille) (Minibacterium massiliensis)
Length = 304
Score = 81.0 bits (191), Expect = 2e-14
Identities = 45/141 (31%), Positives = 75/141 (53%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AFLG+G MG MA+ L++ G+ V ++ ++ + A G + A + +
Sbjct: 10 IAFLGIGLMGKPMASRLLQAGYPVTAWNRTRSKADELAPLGASVAERVADAVAAADIVIT 69
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L + +V V D + K G+L+ID S+ + +++ +G+ F DAPVSG
Sbjct: 70 MLEAGPIVAQVI---DAALPGLKHGALVIDMSSTRQSEAQEVHAKLAAQGVRFIDAPVSG 126
Query: 512 GVMGAXNATLAFMAGGRKEDF 574
GV+GA +LA MAGG +DF
Sbjct: 127 GVVGAEAGSLAIMAGGSAQDF 147
>UniRef50_A0LMG6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=9;
cellular organisms|Rep: 3-hydroxyisobutyrate
dehydrogenase - Syntrophobacter fumaroxidans (strain DSM
10017 / MPOB)
Length = 309
Score = 81.0 bits (191), Expect = 2e-14
Identities = 42/139 (30%), Positives = 78/139 (56%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ ++G G MG M ++++KG+ ++ ++ ++G A+S +
Sbjct: 16 IGWIGTGVMGLSMCGHVMRKGYATSVHNRTRHKAAPLVESGAGWADSPRQVAEQSDVVFT 75
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L + V +VY G++G++ A+ G +L+D +T +P++ ++I A E+G DAPVSG
Sbjct: 76 MLGFPQDVREVYFGRNGLLQAARPGIILVDMTTTEPSLAREIHQAAGEQGAFAVDAPVSG 135
Query: 512 GVMGAXNATLAFMAGGRKE 568
G +GA NA L+ M GG +E
Sbjct: 136 GDVGARNAALSIMLGGDRE 154
>UniRef50_Q67QX0 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Symbiobacterium thermophilum|Rep: 3-hydroxyisobutyrate
dehydrogenase - Symbiobacterium thermophilum
Length = 294
Score = 80.6 bits (190), Expect = 3e-14
Identities = 50/143 (34%), Positives = 69/143 (48%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
N+ F+GLG MG MA NL++ G TV Y+ S+ ++ G A
Sbjct: 4 NLGFIGLGRMGRHMARNLIRAGHTVTLYNRSQAVVDELVAEGGRRAAGPAEVARDARVLF 63
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
+ LT+ VV + + A+ G + +D STI K+I + EKG+ F DAPVS
Sbjct: 64 TCLTTPDVVESILRQ---ALEGAQPGDIFVDHSTIGVRDAKRIAAMCAEKGVQFIDAPVS 120
Query: 509 GGVMGAXNATLAFMAGGRKEDFE 577
GG GA TL M GG + FE
Sbjct: 121 GGPWGAEAGTLTIMCGGDRAAFE 143
>UniRef50_Q12CU4 Cluster: 2-hydroxy-3-oxopropionate reductase; n=17;
Proteobacteria|Rep: 2-hydroxy-3-oxopropionate reductase
- Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 298
Score = 80.6 bits (190), Expect = 3e-14
Identities = 49/146 (33%), Positives = 70/146 (47%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ + FLG G+MG MA L + G+ ++ ++ + + A G T
Sbjct: 10 RKITFLGTGSMGLPMARRLCEAGYALQVWNRTPARAASLAALGATIHEQARAAARDADIV 69
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
S+L + VV DV + GV A K GSL +D ++I P + G+ D PV
Sbjct: 70 VSMLENGAVVQDVLFAQ-GVAAAMKPGSLFLDMASITPREARDHAARLGALGIAHLDTPV 128
Query: 506 SGGVMGAXNATLAFMAGGRKEDFERS 583
SGG +GA TL MAGG+ DFERS
Sbjct: 129 SGGTVGAEQGTLVIMAGGKPADFERS 154
>UniRef50_A0N0V2 Cluster: BtdhL; n=1; Azoarcus anaerobius|Rep: BtdhL
- Azoarcus anaerobius
Length = 303
Score = 80.6 bits (190), Expect = 3e-14
Identities = 46/146 (31%), Positives = 70/146 (47%)
Frame = +2
Query: 143 DKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXX 322
D V ++GLG MG MAANL+ G + Y+ S +A + G A S+
Sbjct: 6 DTRVGWIGLGKMGTPMAANLLAAGHAITVYNRSAARADALVEKGAALAPSVAALARDCAI 65
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
S+++ + + + L GV A G + ID ST+ P + ++I A KG+ + AP
Sbjct: 66 VISMVSDDAALQGITLDAGGVFEAATPGMVFIDMSTVSPALSERIAAAASAKGIHYLRAP 125
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFER 580
VSG A L +A G K+ +ER
Sbjct: 126 VSGSTTTAAAGALTILASGPKDAYER 151
>UniRef50_Q4Q7T9 Cluster: 2-hydroxy-3-oxopropionate reductase,
putative; n=6; Trypanosomatidae|Rep:
2-hydroxy-3-oxopropionate reductase, putative -
Leishmania major
Length = 299
Score = 80.6 bits (190), Expect = 3e-14
Identities = 47/137 (34%), Positives = 73/137 (53%), Gaps = 1/137 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V ++GLG MG MA N++K GF V ++ + + G T + +
Sbjct: 3 VGYIGLGLMGKPMAVNILKAGFPVSVWNRTASKCDDLVAAGATACATPAELAAASDVVFT 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIF-PIALEKGLGFTDAPVS 508
L+ + V++V G +GV A +G++ +D+STI P+V ++I + EK + DAPVS
Sbjct: 63 NLSDSPDVMEVVFGPNGVAAGICEGAIFVDNSTIKPSVAQEIARRLWKEKKVRALDAPVS 122
Query: 509 GGVMGAXNATLAFMAGG 559
GG +GA N TL M GG
Sbjct: 123 GGDIGARNGTLTVMVGG 139
>UniRef50_Q7WG50 Cluster: Probable oxidoreductase; n=1; Bordetella
bronchiseptica|Rep: Probable oxidoreductase - Bordetella
bronchiseptica (Alcaligenes bronchisepticus)
Length = 316
Score = 79.8 bits (188), Expect = 5e-14
Identities = 51/144 (35%), Positives = 68/144 (47%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AFLGLG MG MA NLVK G V GYD + AL+A A+ G A S +
Sbjct: 6 IAFLGLGAMGLPMACNLVKGGHAVTGYDLNPQALDALAQAGGQRAASAREAAAGAALVIA 65
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L + + G DG + G+L I+ STI P I E+G+ D+PV
Sbjct: 66 MLPTATHIQAALEGADGALQGMDPGALFINMSTILPQETDLIAQRLAERGMRMLDSPVGR 125
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
M A TL +A G +D R+
Sbjct: 126 SAMEAQRGTLLILASGSAQDKARA 149
>UniRef50_A5VEA3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=1;
Sphingomonas wittichii RW1|Rep:
2-hydroxy-3-oxopropionate reductase - Sphingomonas
wittichii RW1
Length = 264
Score = 79.8 bits (188), Expect = 5e-14
Identities = 44/143 (30%), Positives = 72/143 (50%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG G +A NL+ G + G+D + L+ G T A S
Sbjct: 3 IGFIGLGVQGLPLALNLLDGGHELHGFDVRPEPLDELRDRGGTVAASPAELGAACEVVMI 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+ S++ V DV G+DGV+A A+ G +++ S++ + + ++G+ DAPVSG
Sbjct: 63 CVVSDQQVRDVLAGEDGVLASARPGLIVVLHSSVSTDTIAEAAKATRDRGVVLVDAPVSG 122
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
G GA T++FM GG + +R
Sbjct: 123 GAQGARARTMSFMVGGEEAALDR 145
>UniRef50_A3JU55 Cluster: Predicted dehydrogenase, with
NAD(P)-binding Rossmann-fold domain; n=2; Bacteria|Rep:
Predicted dehydrogenase, with NAD(P)-binding
Rossmann-fold domain - Rhodobacterales bacterium
HTCC2150
Length = 302
Score = 79.4 bits (187), Expect = 7e-14
Identities = 45/136 (33%), Positives = 65/136 (47%)
Frame = +2
Query: 161 LGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXSILT 340
+GLG+MG +A NL+K GF G D + + A + G A + ++
Sbjct: 6 IGLGDMGSGLAKNLLKAGFETTGIDMKPERMAAFVEMGGRAAVDVADVGANADAVFVMVM 65
Query: 341 SNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVM 520
+ V V G+ G++AH KG +I S+TI P ++I + G+ D PVSGG
Sbjct: 66 NGDQVKSVLFGEGGLLAHMPKGGAVILSATIKPVEAEEIGAAMADSGIHLIDTPVSGGFP 125
Query: 521 GAXNATLAFMAGGRKE 568
GA TL MA G E
Sbjct: 126 GAQGGTLTMMAAGVDE 141
>UniRef50_A0G5G5 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Proteobacteria|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Burkholderia phymatum
STM815
Length = 306
Score = 79.0 bits (186), Expect = 9e-14
Identities = 46/138 (33%), Positives = 67/138 (48%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ + F+GLGNMGG M LV G +V GYD + + + AA G A+SI
Sbjct: 4 ERIGFIGLGNMGGRMTRRLVDAGISVLGYDTAPERVKAA---GAQAASSIADVMKFADVV 60
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
L +KVV V G GV+AH + +++D ST + ++ + G+ + DA +
Sbjct: 61 MMSLPDSKVVEAVVEGDGGVLAHCRARQIVVDLSTAAASSTIRLARRFTQSGVQYVDAGI 120
Query: 506 SGGVMGAXNATLAFMAGG 559
SGG A L M GG
Sbjct: 121 SGGAAAAEKGALTLMVGG 138
>UniRef50_A5USN9 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Roseiflexus|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Roseiflexus sp. RS-1
Length = 302
Score = 78.2 bits (184), Expect = 2e-13
Identities = 45/146 (30%), Positives = 69/146 (47%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ + F+GLG MG MA L+ GF + ++ ++ A G A +
Sbjct: 2 ERLGFIGLGRMGQVMAGRLLAAGFPLTVHNRTRARAEALLAGGAAWAETPAEVTARSDLV 61
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+ILT + V VY G+DG+++ G L I+ STI + + + ++G DAPV
Sbjct: 62 FTILTDDHAVETVYCGRDGLLSTDASGRLFIEMSTIRTSTILSLAGMVDQRGARLLDAPV 121
Query: 506 SGGVMGAXNATLAFMAGGRKEDFERS 583
SG V A L + GGR D ER+
Sbjct: 122 SGTVAPAREGQLLVLVGGRTSDLERA 147
>UniRef50_Q8TT25 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Methanosarcina|Rep: 3-hydroxyisobutyrate dehydrogenase -
Methanosarcina acetivorans
Length = 300
Score = 78.2 bits (184), Expect = 2e-13
Identities = 50/148 (33%), Positives = 71/148 (47%), Gaps = 2/148 (1%)
Frame = +2
Query: 131 SSNTDKN--VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXX 304
+S DKN V +GLG MG A+NL+ +G+ V Y+ +K+ + G T ++
Sbjct: 3 TSGCDKNITVGVIGLGIMGSSFASNLLSRGYNVHVYNRTKEKAQPLIERGATFHSTPREL 62
Query: 305 XXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGL 484
+ LT V V G+DG++ AKKG L ID STIDP+ + A + GL
Sbjct: 63 ASVADIIMTSLTDEAAVNSVAFGEDGLLNGAKKGCLWIDLSTIDPSSSVKHAEAAKKAGL 122
Query: 485 GFTDAPVSGGVMGAXNATLAFMAGGRKE 568
D PV G A L + GG +E
Sbjct: 123 ERLDTPVVGSKDLASKGELIILVGGSQE 150
>UniRef50_A0QUD5 Cluster: 3-hydroxyisobutyrate dehydrogenase family
protein; n=1; Mycobacterium smegmatis str. MC2 155|Rep:
3-hydroxyisobutyrate dehydrogenase family protein -
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length = 326
Score = 77.8 bits (183), Expect = 2e-13
Identities = 49/146 (33%), Positives = 72/146 (49%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ V FLGLGNMG MA LV G + Y+ + A G A S+
Sbjct: 11 QRVGFLGLGNMGRPMARRLVASGTPLTVYNRTAAKCAEFADLGCEVAESVARMGHCSVLL 70
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+ T + V VYLG DG+VA+A+ G++L+D STI P++ ++ G+ F APV
Sbjct: 71 TMLGTDDDVA-QVYLGDDGLVANARAGAVLVDCSTISPDMSARVRARCDRAGVHFLAAPV 129
Query: 506 SGGVMGAXNATLAFMAGGRKEDFERS 583
+GG + LA G ++ FE +
Sbjct: 130 AGGPPVIESGGLAMAVSGDRQAFEHA 155
>UniRef50_Q89HA0 Cluster: Oxidoreductase; n=1; Bradyrhizobium
japonicum|Rep: Oxidoreductase - Bradyrhizobium japonicum
Length = 313
Score = 77.4 bits (182), Expect = 3e-13
Identities = 47/147 (31%), Positives = 68/147 (46%), Gaps = 1/147 (0%)
Frame = +2
Query: 143 DKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXX 322
D+ +LGLG MG M L+K G+ V ++ S+ + + G S
Sbjct: 23 DERFGYLGLGLMGTPMTRRLLKAGYQVSVWNRSEGKVVPIVEAGARHGASPRDVMAGSDI 82
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFP-IALEKGLGFTDA 499
+T V +V G +G+ G L++D S+I P+ + + + G G+ DA
Sbjct: 83 VFMCVTDAAAVEEVIFGAEGLSTAPGAGKLVVDFSSIHPDAARDLATRLKAANGAGWIDA 142
Query: 500 PVSGGVMGAXNATLAFMAGGRKEDFER 580
PVSGG GA TLA MAGG D ER
Sbjct: 143 PVSGGTKGAEEGTLAIMAGGDASDIER 169
>UniRef50_Q1B326 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding protein precursor; n=7; Bacteria|Rep:
6-phosphogluconate dehydrogenase, NAD-binding protein
precursor - Mycobacterium sp. (strain MCS)
Length = 299
Score = 77.4 bits (182), Expect = 3e-13
Identities = 46/146 (31%), Positives = 73/146 (50%)
Frame = +2
Query: 140 TDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXX 319
++ ++ F+GLGNMG MAANL+ G V Y+ S D ++A + G PA ++
Sbjct: 2 SNMHIGFIGLGNMGSAMAANLLAAGHDVTAYNRSPDKVDALSAEGARPARTV-AEACQGD 60
Query: 320 XXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 499
++L ++ V V G DG+VA + ++ + SSTI + +++ E G F A
Sbjct: 61 VVVTMLANDDAVEAVSFGDDGIVASLRPDAIHVSSSTISLALAERLTAAHAEGGSRFVSA 120
Query: 500 PVSGGVMGAXNATLAFMAGGRKEDFE 577
PV G A A L +A G + E
Sbjct: 121 PVFGRPEAAAAAKLFVVAAGAPDTVE 146
>UniRef50_A3WAC4 Cluster: Dehydrogenase; n=4; Bacteria|Rep:
Dehydrogenase - Erythrobacter sp. NAP1
Length = 301
Score = 77.4 bits (182), Expect = 3e-13
Identities = 50/147 (34%), Positives = 74/147 (50%), Gaps = 6/147 (4%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYD----PSKDALNAAAKNG-VTPANS-IXXXX 307
K +AFLGLG MGG M +LV+ G GY+ +++ + G V P S
Sbjct: 5 KRIAFLGLGVMGGPMWGHLVRAGHEATGYNRNFAKAEEWSDRLGDEGLVAPIESDAATAV 64
Query: 308 XXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLG 487
+ L ++ V V G++GV+A K+G+ ID +++ P + ++I GL
Sbjct: 65 RGKDVVLACLGNDDDVASVLFGENGVLAAMKRGATFIDHTSVSPGLARRIADECERLGLH 124
Query: 488 FTDAPVSGGVMGAXNATLAFMAGGRKE 568
DAPVSGG GA N L+ M GG +E
Sbjct: 125 AVDAPVSGGQAGAENGKLSIMCGGSEE 151
>UniRef50_A3VLN6 Cluster: Oxidoreductase; n=1; Rhodobacterales
bacterium HTCC2654|Rep: Oxidoreductase - Rhodobacterales
bacterium HTCC2654
Length = 293
Score = 77.4 bits (182), Expect = 3e-13
Identities = 46/146 (31%), Positives = 70/146 (47%), Gaps = 1/146 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V F GLGN+G MA L ++G + ++ S+ + GV A S
Sbjct: 3 VGFAGLGNIGALMAWRLQERGHDLVVWNRSQAKTQSFRDAGVPVAPSPADLARQVDVLCL 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFP-IALEKGLGFTDAPVS 508
+T K + V G DG+V + ++++D ST+ P+ +QI + E G + DAPVS
Sbjct: 63 CVTDAKALDAVLFGSDGIVGAGRVPAMIVDHSTVPPDATRQIAARVRAEAGAAWVDAPVS 122
Query: 509 GGVMGAXNATLAFMAGGRKEDFERSF 586
GG+ GA LA GG D R++
Sbjct: 123 GGLAGAAAGQLAIFVGGEDADVTRAW 148
>UniRef50_A7DSF1 Cluster: 2-hydroxy-3-oxopropionate reductase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
2-hydroxy-3-oxopropionate reductase - Candidatus
Nitrosopumilus maritimus SCM1
Length = 292
Score = 77.4 bits (182), Expect = 3e-13
Identities = 45/144 (31%), Positives = 67/144 (46%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
K + +GLG +G + +L++ GF V ++ SKD A + G T +S
Sbjct: 2 KKIGIVGLGMLGNAVGLHLLESGFEVTVFNRSKDKTIQAKEKGATVVDSPKEVAEKSDLV 61
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
++ V +V ++G++ K ++ D STIDP+ K I LE G+ D PV
Sbjct: 62 IIVVKDADAVKEVSFEREGIIKSENKKLIVADMSTIDPSESKNISDKFLEFGIHKLDIPV 121
Query: 506 SGGVMGAXNATLAFMAGGRKEDFE 577
GG A L MA G KE FE
Sbjct: 122 MGGPNVAITGDLVMMASGNKESFE 145
>UniRef50_A1R2J4 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Arthrobacter aurescens TC1|Rep: 3-hydroxyisobutyrate
dehydrogenase - Arthrobacter aurescens (strain TC1)
Length = 332
Score = 77.0 bits (181), Expect = 4e-13
Identities = 46/143 (32%), Positives = 63/143 (44%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLGNMG M NL GF + D K++ NG A +
Sbjct: 26 IGFIGLGNMGSGMTRNLQAAGFHLVVNDVRKESAAELLANGAEWAEDAAAVAAGSDVVIT 85
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L + K V V +G G++A G +D ST P V ++ +G+ DAPVSG
Sbjct: 86 MLPTPKHVETVAMGPGGILAGMPDGGTWVDMSTSVPEVANRVREAGSVRGIRVLDAPVSG 145
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
+GA N L GG D ER
Sbjct: 146 MSVGAANGMLQIFVGGEPADVER 168
>UniRef50_A0LTQ8 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=1; Acidothermus cellulolyticus
11B|Rep: 6-phosphogluconate dehydrogenase, NAD-binding
precursor - Acidothermus cellulolyticus (strain ATCC
43068 / 11B)
Length = 305
Score = 76.6 bits (180), Expect = 5e-13
Identities = 51/141 (36%), Positives = 68/141 (48%), Gaps = 5/141 (3%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNA-----AAKNGVTPANSIXXXXXXX 316
VA LGLG MG MAA L G + ++ +++ A AK TPA ++
Sbjct: 4 VAVLGLGAMGSAMAARLHDAGAELILWNRTRERAQALGERLGAKVAATPAEAVADVPVAL 63
Query: 317 XXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 496
L + V DV+LG DGVVA A+ G ++ + ST++P V + I P KG D
Sbjct: 64 TS----LADRRAVEDVFLGPDGVVAGARPGLVVAELSTVEPEVARAIAPELRAKGADILD 119
Query: 497 APVSGGVMGAXNATLAFMAGG 559
PVSG V A L M GG
Sbjct: 120 VPVSGSVAVAREGGLTLMVGG 140
>UniRef50_Q4KH51 Cluster: 3-hydroxyisobutyrate dehydrogenase family
protein; n=16; Gammaproteobacteria|Rep:
3-hydroxyisobutyrate dehydrogenase family protein -
Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
Length = 298
Score = 76.2 bits (179), Expect = 6e-13
Identities = 50/149 (33%), Positives = 75/149 (50%), Gaps = 5/149 (3%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGF--TVRGYDPSKDA--LNAAAKNGVTPANSIXXXXXXX 316
++ F G+G MG M L+ G+ TV +P K A + A A+ TPA
Sbjct: 7 SLGFAGIGLMGLPMCRRLLAAGYPLTVWNRNPEKCAPLVAAGARQVATPAQLCADADLML 66
Query: 317 XXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFP-IALEKGLGFT 493
L + +VV +V G G+ A+ G LL+D S+++P +++ +A +G+ +
Sbjct: 67 M----CLANTEVVREVVFGPQGIAQGARAGQLLLDLSSLEPTATREMAAELAASRGVAWV 122
Query: 494 DAPVSGGVMGAXNATLAFMAGGRKEDFER 580
DAPVSGG GA +LA M GG D ER
Sbjct: 123 DAPVSGGTPGAEAGSLAIMVGGEATDVER 151
>UniRef50_A7PEG7 Cluster: Chromosome chr11 scaffold_13, whole genome
shotgun sequence; n=2; Vitis vinifera|Rep: Chromosome
chr11 scaffold_13, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 348
Score = 76.2 bits (179), Expect = 6e-13
Identities = 51/151 (33%), Positives = 73/151 (48%), Gaps = 1/151 (0%)
Frame = +2
Query: 110 TAARRAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPAN 289
TAA S ++ V ++G G MG M A+L+K G+TV ++ + G A+
Sbjct: 37 TAAVAEPVSPSNTRVGWIGTGVMGRSMCAHLMKAGYTVTIFNRTISKAQPLLDMGAHHAS 96
Query: 290 SIXXXXXXXXXXXSILTSNKVVLDVYLG-KDGVVAHAKKGSLLIDSSTIDPNVPKQIFPI 466
S SI+ V V L G ++ + G +L+D +T DP++ +I
Sbjct: 97 SPLALASQSDVVFSIVGFPSDVRSVLLDPSSGALSGLRPGGVLVDMTTSDPSLAAEIASS 156
Query: 467 ALEKGLGFTDAPVSGGVMGAXNATLAFMAGG 559
A +G DAPVSGG GA NATLA AGG
Sbjct: 157 AASRGCFSVDAPVSGGDRGAKNATLAIFAGG 187
>UniRef50_A2U9T6 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Bacillaceae|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Bacillus coagulans 36D1
Length = 294
Score = 75.8 bits (178), Expect = 9e-13
Identities = 45/142 (31%), Positives = 69/142 (48%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ ++GLG+MG MA L+ F + Y+ + A+ G + +
Sbjct: 8 IGWIGLGHMGSPMARRLLDAHFDLFVYNRTIKKTEKLAEAGAAVCKTPKDIAENADVIVT 67
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+LT+ V +V G+DGV+A KG ++D ST+ P+ + EK F DAPVSG
Sbjct: 68 MLTNAAAVENVLQGEDGVLAGLTKGKTVVDMSTVSPSDSIRFAKWVEEKRGHFIDAPVSG 127
Query: 512 GVMGAXNATLAFMAGGRKEDFE 577
V A L +AGGRKE+ +
Sbjct: 128 SVQPAKEGNLVILAGGRKEEID 149
>UniRef50_Q4WV01 Cluster: Oxidoreductase, acting on the CH-OH group
of donors, NAD or NADP as acceptor; n=7;
Pezizomycotina|Rep: Oxidoreductase, acting on the CH-OH
group of donors, NAD or NADP as acceptor - Aspergillus
fumigatus (Sartorya fumigata)
Length = 435
Score = 75.8 bits (178), Expect = 9e-13
Identities = 46/142 (32%), Positives = 68/142 (47%), Gaps = 3/142 (2%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG MG MA NLV++G+ V G+D ++ G PA+S+
Sbjct: 6 IGFVGLGAMGFGMATNLVREGYPVVGFDVFPASVQRFQSQGGIPASSLRESAEGKDFYIC 65
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG---LGFTDAP 502
++ S V V G DGVV K + L ST+ + + + +G + F D P
Sbjct: 66 MVASAPQVQSVLFGDDGVVQFLPKNATLFLCSTVPASYAQSVAAELQSRGRADIRFIDCP 125
Query: 503 VSGGVMGAXNATLAFMAGGRKE 568
VSGG A + TL+ MAG +E
Sbjct: 126 VSGGAKRAADGTLSIMAGASEE 147
>UniRef50_Q3DYV4 Cluster: NADP oxidoreductase, coenzyme
F420-dependent:6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Chloroflexus|Rep: NADP oxidoreductase,
coenzyme F420-dependent:6-phosphogluconate
dehydrogenase, NAD-binding - Chloroflexus aurantiacus
J-10-fl
Length = 289
Score = 75.4 bits (177), Expect = 1e-12
Identities = 48/144 (33%), Positives = 72/144 (50%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+A +GLG MG MA L+K GF V G++ S L+ A G+ P +
Sbjct: 3 IALIGLGLMGRPMARTLLKAGFNVTGWNRSP--LDPALTEGI-PLAATLAEAAQAETLIL 59
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L+ + V ++ D ++ ++G L+ID + DP + +G+G+ DAPVSG
Sbjct: 60 MLSDSTAVAELLSRLDPLL---REGQLIIDMGSSDPRHSQTHATTLANRGIGWVDAPVSG 116
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
G GA TLA M GG D ER+
Sbjct: 117 GPEGAAAGTLAIMVGGTASDVERA 140
>UniRef50_Q84H84 Cluster: Putative oxidoreductase; n=1; Arthrobacter
sp. BP2|Rep: Putative oxidoreductase - Arthrobacter sp.
BP2
Length = 278
Score = 74.5 bits (175), Expect = 2e-12
Identities = 48/143 (33%), Positives = 72/143 (50%), Gaps = 2/143 (1%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSI-XXXXXXXXX 322
K + F+GLG MG MA NL + GF V GYD + + A G+T A ++
Sbjct: 3 KKIGFVGLGTMGLPMAVNLNRAGFEVIGYDAFEGSRQKAIAAGITMAETLKDVAEQADDA 62
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG-LGFTDA 499
S++ +DV LG+DG+++ K +I ST+DP+ ++ E G + A
Sbjct: 63 IVSMVRDYAQNVDVILGQDGLLSANPKNLTIIVMSTLDPDTMNELGQQVEEHGEVRLIAA 122
Query: 500 PVSGGVMGAXNATLAFMAGGRKE 568
VSGG GA TL+ MA G ++
Sbjct: 123 AVSGGSTGAEAGTLSIMASGAED 145
>UniRef50_Q18X68 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Desulfitobacterium hafniense|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Desulfitobacterium hafniense (strain DCB-2)
Length = 298
Score = 74.1 bits (174), Expect = 3e-12
Identities = 48/142 (33%), Positives = 70/142 (49%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG MG MA NL+K G + YD + + G A I S
Sbjct: 3 LGFIGLGQMGKHMALNLLKSGEELIVYDQRPASYPEFEQRGARTAAQIRDVAEADIIFCS 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L +++VV V LG+ G+ + G +++D+STI+ + +I G+ F DAPVSG
Sbjct: 63 -LPNSEVVCQVVLGETGLKKVLRAGQIIVDTSTINYSTTLEIGKQLESVGVEFIDAPVSG 121
Query: 512 GVMGAXNATLAFMAGGRKEDFE 577
A TL M GG++E FE
Sbjct: 122 MESRAKEGTLTTMCGGKQELFE 143
>UniRef50_A1B741 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3;
Bacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Paracoccus denitrificans (strain Pd 1222)
Length = 309
Score = 73.7 bits (173), Expect = 3e-12
Identities = 48/143 (33%), Positives = 67/143 (46%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG MG MAANL G + D S+ A G T A + +
Sbjct: 3 IGFIGLGKMGRGMAANLQTGGAALVVADLSRTAAEEFTVRGATWAETPADLARDCGIVFT 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L + V + G G+V G++ +D ST +V +QI KG+ F DAPVSG
Sbjct: 63 SLPTPADVRNAGFGPRGLVEGMAPGTVWLDLSTNSVDVVRQIHAELAPKGIHFIDAPVSG 122
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
G GA + LA GG +E ++R
Sbjct: 123 GPAGAASGQLAIWCGGEREVYDR 145
>UniRef50_Q55JR1 Cluster: Putative uncharacterized protein; n=2;
Filobasidiella neoformans|Rep: Putative uncharacterized
protein - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 605
Score = 73.7 bits (173), Expect = 3e-12
Identities = 46/139 (33%), Positives = 71/139 (51%), Gaps = 3/139 (2%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V ++GLG MG MAA+LV +G+ V+ +D +L A+ G P++S
Sbjct: 9 VGWIGLGAMGSGMAASLVSQGYKVQAFDVYPPSLKRVAEQGAIPSSSPRDAAEGVQVLCL 68
Query: 332 ILTSNKVVLDVYLGKDGVVAH-AKKGSLLIDSSTIDPNVPKQIFP--IALEKGLGFTDAP 502
++ + + V + GKDG VA K G+ +I ST+ P+ ++ L K +G D+P
Sbjct: 69 MVVNAQQVEETLFGKDGGVAEILKNGASIIVFSTVPPSFLVEVARRLDKLGKNIGLVDSP 128
Query: 503 VSGGVMGAXNATLAFMAGG 559
VSGG A LA M+ G
Sbjct: 129 VSGGSTRAAQGQLAIMSSG 147
>UniRef50_Q73P00 Cluster: 3-hydroxyacid dehydrogenase family
protein; n=4; Bacteria|Rep: 3-hydroxyacid dehydrogenase
family protein - Treponema denticola
Length = 292
Score = 73.3 bits (172), Expect = 5e-12
Identities = 45/143 (31%), Positives = 70/143 (48%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
+V F+GLG MG MA L G + + +K + G +
Sbjct: 7 DVGFIGLGVMGKSMAERLRAAGAKMHVFTRTKKSAEEILSKGAIWYDDPASLAPNCKIIF 66
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
+I+ + V + Y G+ G++ AK G++ D +T P + K+I+ A +K DAPVS
Sbjct: 67 TIVGYPQDVEETYFGEKGLLKTAKPGTIFADMTTSSPILAKKIYDEAKKKECFSVDAPVS 126
Query: 509 GGVMGAXNATLAFMAGGRKEDFE 577
GG +GA N TL+ MAGG + F+
Sbjct: 127 GGDIGAKNGTLSIMAGGDESAFK 149
>UniRef50_Q39MY1 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Burkholderia sp. 383|Rep: 3-hydroxyisobutyrate
dehydrogenase - Burkholderia sp. (strain 383)
(Burkholderia cepacia (strain ATCC 17760/ NCIB 9086 /
R18194))
Length = 303
Score = 73.3 bits (172), Expect = 5e-12
Identities = 47/144 (32%), Positives = 66/144 (45%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
++ FLGLG MG MA L+ + + YDPS A+ G S
Sbjct: 6 DIGFLGLGKMGAPMAERLLGQACRLHVYDPSAQAVAPFVDGGAVAHASPRAVADAASIVF 65
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
+ L + V L V LG DGVV H L ++ STI ++ ++I ++G+ DAPVS
Sbjct: 66 ACLPNRDVSLAVGLGPDGVV-HGSAVRLYVEMSTIGQDMIERIGEGLAQRGIDIVDAPVS 124
Query: 509 GGVMGAXNATLAFMAGGRKEDFER 580
GG A TLA + G E+
Sbjct: 125 GGPSAARAGTLAMLVSGMPSAVEQ 148
>UniRef50_Q1GJB9 Cluster: 6-phosphogluconate dehydrogenase
NAD-binding; n=1; Silicibacter sp. TM1040|Rep:
6-phosphogluconate dehydrogenase NAD-binding -
Silicibacter sp. (strain TM1040)
Length = 304
Score = 73.3 bits (172), Expect = 5e-12
Identities = 49/147 (33%), Positives = 72/147 (48%), Gaps = 2/147 (1%)
Frame = +2
Query: 143 DKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGV-TPANSIXXXXXXXX 319
+K +GLG MG MA +L+K GF V GYDP++ A AA GV A++
Sbjct: 6 NKRAGVIGLGAMGLGMARSLLKAGFAVSGYDPAETARENAAAAGVWLTADTDAVFADCDV 65
Query: 320 XXXSILTSNKVVLDVYLGK-DGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 496
S+ T+ V+ V + G +A +++D+ST + + + G GF D
Sbjct: 66 IVLSLPTAQHVLAVVQAAQAAGHLAQTGAARVIVDTSTSEAATSRTLAAELSALGHGFLD 125
Query: 497 APVSGGVMGAXNATLAFMAGGRKEDFE 577
APVSGG GA + L+ M GG + E
Sbjct: 126 APVSGGPAGAASGQLSVMLGGETQWLE 152
>UniRef50_Q49A26 Cluster: Cytokine-like nuclear factor n-pac; n=46;
Euteleostomi|Rep: Cytokine-like nuclear factor n-pac -
Homo sapiens (Human)
Length = 553
Score = 73.3 bits (172), Expect = 5e-12
Identities = 42/162 (25%), Positives = 75/162 (46%)
Frame = +2
Query: 92 STQCLYTAARRAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKN 271
S Q + A + TDK + FLGLG MG + +NL+K G TV ++ + + + +
Sbjct: 250 SIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQE 309
Query: 272 GVTPANSIXXXXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPK 451
G + + ++ K D+ LG GV+ + G +D ST+D +
Sbjct: 310 GARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVT 369
Query: 452 QIFPIALEKGLGFTDAPVSGGVMGAXNATLAFMAGGRKEDFE 577
++ + + +G F +APVSG + + L +A G + +E
Sbjct: 370 ELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYE 411
>UniRef50_A7IE35 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Proteobacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Xanthobacter sp. (strain Py2)
Length = 330
Score = 72.9 bits (171), Expect = 6e-12
Identities = 41/143 (28%), Positives = 66/143 (46%)
Frame = +2
Query: 155 AFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXSI 334
A +GLG+MG MA +L + GF V G+D + A+ A G A+S S+
Sbjct: 36 AVIGLGSMGYGMAQSLKRAGFDVAGFDVNAAAVERFAAEGGRGASSPAEAARDADVVVSV 95
Query: 335 LTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGG 514
+ + + G DGV G++ + S+T+DP + + + G + DAP+SGG
Sbjct: 96 VVNAAQTETILFGADGVAQTLADGAVFLSSATMDPEIARTLAARLEATGRLYLDAPISGG 155
Query: 515 VMGAXNATLAFMAGGRKEDFERS 583
A L +A G F ++
Sbjct: 156 AQRAAEGALTILASGSPAAFAKA 178
>UniRef50_A3K497 Cluster: Probable 6-phosphogluconate dehydrogenase
protein; n=1; Sagittula stellata E-37|Rep: Probable
6-phosphogluconate dehydrogenase protein - Sagittula
stellata E-37
Length = 298
Score = 72.9 bits (171), Expect = 6e-12
Identities = 44/140 (31%), Positives = 69/140 (49%), Gaps = 2/140 (1%)
Frame = +2
Query: 143 DKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXX 322
DK + F+GLGNMG MA +LV+ GF V YD + A A+ +
Sbjct: 3 DKLIGFIGLGNMGTAMARHLVRGGFEVLAYDIDAEKRAAFAEETGMRNPATVAELAEATV 62
Query: 323 XXSILTSNKVVLDVYL--GKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTD 496
++L + +V V G+ G++ + G+L+ID+++ P +++ + +G D
Sbjct: 63 LLTMLPNGAIVRKVLDEGGEAGLLGQMQPGTLMIDTTSSPPEATRELAAVLNARGCHLVD 122
Query: 497 APVSGGVMGAXNATLAFMAG 556
APVSG GA A L FM G
Sbjct: 123 APVSGARAGAEAADLVFMIG 142
>UniRef50_A0C2T7 Cluster: Chromosome undetermined scaffold_145,
whole genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_145,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 299
Score = 72.9 bits (171), Expect = 6e-12
Identities = 48/143 (33%), Positives = 70/143 (48%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLGNMG MA NL K V YD S + + + P N + +
Sbjct: 14 IGFIGLGNMGIGMAHNLAKTR-VVYAYDVSPAWQSNIESSNIKPVNQVADVAANADTIIT 72
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L ++K+V V + +KK +LIDSSTI P ++ +A + + DAPVSG
Sbjct: 73 MLPNDKIVKSV---AQEIFKKSKK--ILIDSSTISPYTSYELAKMAQDTQNIYADAPVSG 127
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
V A T+ FM G KE +E+
Sbjct: 128 SVSEAKLGTITFMVGAEKELYEK 150
>UniRef50_Q0LNZ7 Cluster: 3-hydroxyisobutyrate dehydrogenase
precursor; n=1; Herpetosiphon aurantiacus ATCC
23779|Rep: 3-hydroxyisobutyrate dehydrogenase precursor
- Herpetosiphon aurantiacus ATCC 23779
Length = 301
Score = 72.5 bits (170), Expect = 8e-12
Identities = 46/144 (31%), Positives = 63/144 (43%), Gaps = 1/144 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVR-GYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
+ +GLG MG MA+NL++ G+ + G ++A A G A S
Sbjct: 6 IGLIGLGAMGAPMASNLLQAGYQLTVGVHQRREAAEQLALQGAIIAESYQALGENSDIVI 65
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
+++ V LG +G GS+ ID STI P + I E+ + DAPVS
Sbjct: 66 TMVPDAPQVEAALLGTNGAAYGMAAGSICIDMSTIAPTASRAIAAKLAERQIAMLDAPVS 125
Query: 509 GGVMGAXNATLAFMAGGRKEDFER 580
GG A LA M GG FER
Sbjct: 126 GGPARAKTGELAIMVGGEPSTFER 149
>UniRef50_A1CAY2 Cluster: Oxidoreductase, acting on the CH-OH group
of donors, NAD or NADP as acceptor; n=2;
Aspergillus|Rep: Oxidoreductase, acting on the CH-OH
group of donors, NAD or NADP as acceptor - Aspergillus
clavatus
Length = 436
Score = 72.5 bits (170), Expect = 8e-12
Identities = 45/142 (31%), Positives = 67/142 (47%), Gaps = 3/142 (2%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG MG MA NLV++G+ V GYD ++ G PA+S+
Sbjct: 6 IGFVGLGAMGFGMATNLVREGYPVVGYDVFPASVQRFQTAGGIPASSLRESAEGKDFYVC 65
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG---LGFTDAP 502
++ S V V G DG+V + + L ST+ + + + G + F D P
Sbjct: 66 MVASAPQVQSVLFGDDGIVQYLPPNATLFLCSTVPASYAQSVAAELQSLGRADIRFIDCP 125
Query: 503 VSGGVMGAXNATLAFMAGGRKE 568
VSGG A + TL+ MAG +E
Sbjct: 126 VSGGAKRAADGTLSIMAGAPEE 147
>UniRef50_A3H5R1 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Caldivirga maquilingensis IC-167|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Caldivirga maquilingensis IC-167
Length = 295
Score = 72.5 bits (170), Expect = 8e-12
Identities = 44/147 (29%), Positives = 73/147 (49%), Gaps = 1/147 (0%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKD-ALNAAAKNGVTPANSIXXXXXXXXXX 325
NV +GLG MG +A NL G + ++ + A+ A +N V N+
Sbjct: 3 NVGLIGLGTMGWRIAKNLKDDGLLIGVFNRTMSKAIKFAEENKVNVFNNPAELARNVDVV 62
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
SI++ + V + LG++GV+ K+GSL+I+ STI P+ ++ EKG DAP+
Sbjct: 63 LSIVSDDDAVKSIMLGENGVINGIKQGSLVIEMSTISPSTSIELANKIKEKGGLMVDAPI 122
Query: 506 SGGVMGAXNATLAFMAGGRKEDFERSF 586
G + + GG +E +ER++
Sbjct: 123 IGTSILIEKREAVVLIGGEREAYERAY 149
>UniRef50_Q1N6I0 Cluster: Putative oxidoreductase protein; n=1;
Oceanobacter sp. RED65|Rep: Putative oxidoreductase
protein - Oceanobacter sp. RED65
Length = 289
Score = 72.1 bits (169), Expect = 1e-11
Identities = 45/147 (30%), Positives = 74/147 (50%), Gaps = 2/147 (1%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKN--GVTPANSIXXXXXXXXX 322
N++F+GLG MG MA +LV+ + ++ S +N T ANS+
Sbjct: 2 NISFIGLGKMGYPMAKHLVQANHQLEVFNRSPSKSEDFKRNFEQCTIANSLTDCGKHSEI 61
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
+ +++ V + GKD + ++ K G+L+ID +T + ++ LEK + + DAP
Sbjct: 62 IILCIGNDEDVRNTLTGKDSLYSNLKPGTLVIDHTTTSAELACEMQAKLLEKQVDYVDAP 121
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFERS 583
VSGG GA + L M GG+ ER+
Sbjct: 122 VSGGEQGAISGQLTIMCGGQALAAERA 148
>UniRef50_A3H9B3 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Caldivirga maquilingensis IC-167|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Caldivirga maquilingensis IC-167
Length = 293
Score = 72.1 bits (169), Expect = 1e-11
Identities = 43/141 (30%), Positives = 67/141 (47%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V +GLG MGG L+ KGF + YD +D +N K G T A+S +
Sbjct: 3 VGLVGLGRMGGAFGRVLLSKGFNLVVYDVVRDKVNEFVKLGATGASSPADLASRVDIVLT 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+ ++ VLDVYLG +G+++ AK G + +++ST D ++ + +GF A +
Sbjct: 63 NVPRSEDVLDVYLGGNGILSGAKPGLIAVETSTTDIKTKLRVAEECRRRNVGFIVAMLGK 122
Query: 512 GVMGAXNATLAFMAGGRKEDF 574
V A GG +E F
Sbjct: 123 TVPQAERGETPLFVGGPEEVF 143
>UniRef50_O33730 Cluster: Uncharacterized oxidoreductase Sfri_1503;
n=167; Bacteria|Rep: Uncharacterized oxidoreductase
Sfri_1503 - Shewanella frigidimarina (strain NCIMB 400)
Length = 291
Score = 72.1 bits (169), Expect = 1e-11
Identities = 46/143 (32%), Positives = 71/143 (49%), Gaps = 1/143 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPS-KDALNAAAKNGVTPANSIXXXXXXXXXXX 328
VAF+GLG MG MA +LVK+G V Y+ + A + G A++
Sbjct: 4 VAFIGLGVMGFPMAGHLVKQGHDVTVYNRTGAKATQWVEQYGGKKADTPKDAAQGQDIVF 63
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
+ + ++ + V LG+ G+V G++L+D +T +V ++I + F DAPVS
Sbjct: 64 TCVGNDDDLRQVVLGEHGIVHGMHAGAILVDHTTASADVAREIAAYIEPLNIAFLDAPVS 123
Query: 509 GGVMGAXNATLAFMAGGRKEDFE 577
GG GA N L M GG + F+
Sbjct: 124 GGQAGAENGALTVMMGGDQAHFD 146
>UniRef50_Q89RT2 Cluster: Bll2680 protein; n=1; Bradyrhizobium
japonicum|Rep: Bll2680 protein - Bradyrhizobium
japonicum
Length = 300
Score = 71.7 bits (168), Expect = 1e-11
Identities = 41/150 (27%), Positives = 69/150 (46%)
Frame = +2
Query: 134 SNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXX 313
++ +NVAF+G+G MG M+ + K G+ V +D S N A G++ A S
Sbjct: 2 TDASRNVAFIGIGKMGLPMSVLVAKAGYAVTAFDRSAARTNEARAQGISIAASPDDAVSG 61
Query: 314 XXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 493
+ L + + LG GV+A G++LI++ST+ ++ A +G+ +
Sbjct: 62 KEAVITSLPDDTALRGALLGPAGVIAAMAPGAVLIETSTVSVEASTEVAASAQARGVLYL 121
Query: 494 DAPVSGGVMGAXNATLAFMAGGRKEDFERS 583
APVSG L G K+ F+ +
Sbjct: 122 RAPVSGNASIVHTGALTCFVSGPKDAFDNA 151
>UniRef50_Q0RCX7 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Frankia alni ACN14a|Rep: 3-hydroxyisobutyrate
dehydrogenase - Frankia alni (strain ACN14a)
Length = 313
Score = 70.9 bits (166), Expect = 2e-11
Identities = 47/145 (32%), Positives = 67/145 (46%), Gaps = 2/145 (1%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKD--ALNAAAKNGVTPANSIXXXXXXXXXX 325
V F+GLG MG MA +L + GF Y+ ++ A +A + G A
Sbjct: 3 VGFVGLGTMGFPMAGHLARAGFDTVVYNRTETTAARWSAVQRGRVAATPAQAAAGSDVVC 62
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+ + V V LG DG + G+ ++D +T + +I A E G+GF DAPV
Sbjct: 63 VCVGADDDV-RSVLLGPDGALGALAPGATIVDHTTTSAELAVEIAARAAEVGVGFVDAPV 121
Query: 506 SGGVMGAXNATLAFMAGGRKEDFER 580
SGG GA L+ M GG + ER
Sbjct: 122 SGGQAGAEAGRLSVMCGGEVDTVER 146
>UniRef50_A0G5F9 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Burkholderia|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Burkholderia phymatum
STM815
Length = 307
Score = 70.9 bits (166), Expect = 2e-11
Identities = 46/149 (30%), Positives = 69/149 (46%)
Frame = +2
Query: 113 AARRAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANS 292
++ +A S + F+G+G MG MA L++ G + +D + A+ G A S
Sbjct: 2 SSSQASSQQRGPLLGFVGVGTMGRPMARRLIEAGHALVVFDRDEAAVAELKAIGAQAAAS 61
Query: 293 IXXXXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIAL 472
+ + L + + V LG DG + +L+D ST+ V K++ L
Sbjct: 62 VREIADSARIVFTSLPTPAIFRQVALG-DGGLIEGSAIKVLVDLSTVGSRVEKEVAQGLL 120
Query: 473 EKGLGFTDAPVSGGVMGAXNATLAFMAGG 559
KG+ DAPVSGG GA TLA MA G
Sbjct: 121 AKGVETVDAPVSGGAAGAKKGTLAIMAAG 149
>UniRef50_A1WM48 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Verminephrobacter eiseniae EF01-2|Rep:
3-hydroxyisobutyrate dehydrogenase - Verminephrobacter
eiseniae (strain EF01-2)
Length = 301
Score = 70.5 bits (165), Expect = 3e-11
Identities = 43/131 (32%), Positives = 59/131 (45%)
Frame = +2
Query: 158 FLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXSIL 337
F+GLGNMGG M L+ G TV +D AL A +G +S L
Sbjct: 9 FIGLGNMGGPMVKRLLHAGHTVLVFDRDAAALARAVADGAQARSSALDVADAAATIFLSL 68
Query: 338 TSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGV 517
V V +DG++ K+ ++D STI P +G+ + D+PVSGG+
Sbjct: 69 PDGPAVQHVISAQDGLL-QGKRVKCVVDLSTIGPRAAVAASQALGARGIAYVDSPVSGGI 127
Query: 518 MGAXNATLAFM 550
GA TLA M
Sbjct: 128 GGAERGTLAVM 138
>UniRef50_A0NRG5 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding protein; n=1; Stappia aggregata IAM
12614|Rep: 6-phosphogluconate dehydrogenase, NAD-binding
protein - Stappia aggregata IAM 12614
Length = 291
Score = 70.5 bits (165), Expect = 3e-11
Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 1/141 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKD-ALNAAAKNGVTPANSIXXXXXXXXXXX 328
V F GLG MG MAANL G V ++ + + A A+ + PA +
Sbjct: 3 VGFAGLGRMGVRMAANLAAAGLEVSIWNRTAETARTFASAHNAFPAATPKDLAERSDIVI 62
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
++L + VY G DG+ + +L++ T+ + +++ A EKG F DAPVS
Sbjct: 63 TMLADDAAAETVYFGPDGLFEASSGAQVLVEMGTLSVPMAERLARAAQEKGRRFVDAPVS 122
Query: 509 GGVMGAXNATLAFMAGGRKED 571
G A +A L MAG D
Sbjct: 123 GATQAAKDAKLLIMAGATASD 143
>UniRef50_Q8VYC5 Cluster: Fructose-bisphosphate aldolase; n=12;
cellular organisms|Rep: Fructose-bisphosphate aldolase -
Arabidopsis thaliana (Mouse-ear cress)
Length = 1373
Score = 70.5 bits (165), Expect = 3e-11
Identities = 51/142 (35%), Positives = 65/142 (45%), Gaps = 3/142 (2%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG MG MAA+L+K F+V GYD K L G ANS
Sbjct: 324 IGFIGLGAMGFGMAAHLLKSNFSVCGYDVYKPTLVRFENAGGLAANSPAEVTKDVDVLVI 383
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALE---KGLGFTDAP 502
++T+ DV G G V G+ ++ +ST+ P Q+ LE K L DAP
Sbjct: 384 MVTNEVQAEDVLYGHLGAVEAIPSGATVVLASTVSPAFVSQL-ERRLENEGKDLKLVDAP 442
Query: 503 VSGGVMGAXNATLAFMAGGRKE 568
VSGGV A L MA G E
Sbjct: 443 VSGGVKRAAMGELTIMASGTDE 464
Score = 47.2 bits (107), Expect = 3e-04
Identities = 35/146 (23%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V F+GL + +A++L++ GF V+ ++ S + + + G +S
Sbjct: 5 VGFVGLDSFSFELASSLLRSGFKVQAFEISTELVEKFIELGGHKCDSPADVGKAAAAVVV 64
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEK--GLGFTDAPV 505
+L+ + DV G +GV+ +K ++L+ SSTI +++ EK + DA V
Sbjct: 65 VLSHPDQIQDVIFGDEGVMKGLQKDAVLLLSSTISTLQLQKLEKQLTEKREQIFVVDAYV 124
Query: 506 SGGVMGAXNATLAFMAGGRKEDFERS 583
G+ + L +A GR + R+
Sbjct: 125 LKGMSELLDGKLMIIASGRSDSITRA 150
>UniRef50_Q7WNK6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Bordetella bronchiseptica|Rep: 3-hydroxyisobutyrate
dehydrogenase - Bordetella bronchiseptica (Alcaligenes
bronchisepticus)
Length = 306
Score = 70.1 bits (164), Expect = 4e-11
Identities = 42/139 (30%), Positives = 61/139 (43%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG MGG + +L G V YD A+ AAA G PA S+
Sbjct: 9 IGFIGLGAMGGPICGHLAAAGHDVAAYDIQPAAVQAAAARGARPAASVREAADGAALLVV 68
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
++ + V G+ G A G+ + +ST+ P + + E G G D PVSG
Sbjct: 69 MVHNAGQADAVLFGEGGAAAALPAGATVWLASTVAPAYARGLQARLREHGAGLVDGPVSG 128
Query: 512 GVMGAXNATLAFMAGGRKE 568
G GA L +A G+ +
Sbjct: 129 GATGAQAGALTIIASGQAQ 147
>UniRef50_Q0F1Y7 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding protein; n=1; Mariprofundus ferrooxydans
PV-1|Rep: 6-phosphogluconate dehydrogenase, NAD-binding
protein - Mariprofundus ferrooxydans PV-1
Length = 289
Score = 70.1 bits (164), Expect = 4e-11
Identities = 41/138 (29%), Positives = 68/138 (49%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+N+ F+GLG MG MAAN++K+G + Y+ + + A G A+
Sbjct: 3 QNIGFIGLGIMGEAMAANILKQGHPLIVYNRTVEKAAALVDAGAMVADKPSLVADASDVI 62
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+LT + V V G++G+++ +G +I+ ST+ K+ + G+ DAPV
Sbjct: 63 ILMLTGEEAVDAVLFGEEGLLSGDCEGKTVINMSTVPVECSKRWAKELADHGMTLIDAPV 122
Query: 506 SGGVMGAXNATLAFMAGG 559
SG + A TL +AGG
Sbjct: 123 SGSKVPAQTGTLVILAGG 140
>UniRef50_A0GPK7 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=4; Burkholderia|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Burkholderia phytofirmans
PsJN
Length = 297
Score = 70.1 bits (164), Expect = 4e-11
Identities = 51/144 (35%), Positives = 67/144 (46%), Gaps = 4/144 (2%)
Frame = +2
Query: 140 TDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKD---ALNAAAKNGVTPANSIXXXXX 310
T + F GLG MG MA L G +R ++ S + AL A+A N V S
Sbjct: 2 TSARLGFCGLGKMGWPMAQRLADAGHALRVWNRSNEKAAALQASATNCVA-CESPAQVAA 60
Query: 311 XXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEK-GLG 487
L V V G DG+ A++G+ L+D ST+ P+ + E+ G
Sbjct: 61 GAGIVMLCLADAAAVEAVAFGVDGLANRARRGATLVDHSTLAPSQTRAFARRWREQTGGD 120
Query: 488 FTDAPVSGGVMGAXNATLAFMAGG 559
+ DAPVSGG GA TLA MAGG
Sbjct: 121 WIDAPVSGGTSGAAAGTLAIMAGG 144
>UniRef50_Q830A7 Cluster: 2-hydroxy-3-oxopropionate reductase; n=7;
Firmicutes|Rep: 2-hydroxy-3-oxopropionate reductase -
Enterococcus faecalis (Streptococcus faecalis)
Length = 296
Score = 69.7 bits (163), Expect = 6e-11
Identities = 39/142 (27%), Positives = 66/142 (46%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+G G MG + N++K +V Y+ +K + G ++ +
Sbjct: 4 IGFIGTGVMGKSIIRNMMKNNLSVNVYNRTKSKTDDLVAEGAVWYDTPKAIAEASDIIFT 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
++ V VY + G+ G +++D +T P + ++I A E G DAPVSG
Sbjct: 64 MVGFPSDVEGVYFNETGIFQADLTGKIVVDLTTSTPTLAEKIAKKAAEVGAHALDAPVSG 123
Query: 512 GVMGAXNATLAFMAGGRKEDFE 577
G +GA N TL M GG +E ++
Sbjct: 124 GDLGAKNGTLTIMVGGDQESYD 145
>UniRef50_Q84VC8 Cluster: Gamma hydroxybutyrate dehydrogenase-like
protein; n=3; Magnoliophyta|Rep: Gamma hydroxybutyrate
dehydrogenase-like protein - Oryza sativa subsp.
japonica (Rice)
Length = 293
Score = 69.7 bits (163), Expect = 6e-11
Identities = 43/138 (31%), Positives = 61/138 (44%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V FLGLG MG MAANL++ GF V ++ + G + +
Sbjct: 3 VGFLGLGIMGKAMAANLLRHGFRVTVWNRTLSKCQELVALGAAVGETPAAVVAKCRYTIA 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L+ L V KDGV+ +G +D ST+D +I +KG F +APVSG
Sbjct: 63 MLSDPSAALSVVFDKDGVLEQIGEGKGYVDMSTVDAATSCKISEAIKQKGGAFVEAPVSG 122
Query: 512 GVMGAXNATLAFMAGGRK 565
A + L +A G K
Sbjct: 123 SKKPAEDGQLVILAAGDK 140
>UniRef50_Q7WCG3 Cluster: Putative uncharacterized protein; n=2;
Bordetella|Rep: Putative uncharacterized protein -
Bordetella parapertussis
Length = 296
Score = 69.3 bits (162), Expect = 7e-11
Identities = 47/146 (32%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
K VAF+G+GNMG MA + GF + D + D L A A+ GV SI
Sbjct: 5 KTVAFIGVGNMGAPMARCARRAGFELIVCDRNPDVLAAFAQEGVRVTASISDCAAADAVV 64
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKG--SLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 499
+L ++ +++ LG G+ G ++ ST P+ + + G DA
Sbjct: 65 V-LLANDAQIMETMLGGQGLAQAVPAGHRPIVCMMSTTLPDTLRALEAPLAAVGARLVDA 123
Query: 500 PVSGGVMGAXNATLAFMAGGRKEDFE 577
PVSGG++GA TL M GG D E
Sbjct: 124 PVSGGIVGAEAGTLTIMMGGETADVE 149
>UniRef50_Q39FA8 Cluster: 2-hydroxy-3-oxopropionate reductase; n=22;
Burkholderiales|Rep: 2-hydroxy-3-oxopropionate reductase
- Burkholderia sp. (strain 383) (Burkholderia cepacia
(strain ATCC 17760/ NCIB 9086 / R18194))
Length = 287
Score = 69.3 bits (162), Expect = 7e-11
Identities = 44/137 (32%), Positives = 65/137 (47%), Gaps = 3/137 (2%)
Frame = +2
Query: 176 MGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXSILTSNKVV 355
MG M +L+ G V ++ S+D A K+G + + + V
Sbjct: 1 MGAPMIRHLLAAGHRVSVWNRSRDKAEALVKDGAQVVGTPRELAERVDTVFVCVLDGRAV 60
Query: 356 LDVYLGKDGVV---AHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGA 526
DV G+ G++ A A++ ++D S+I P + A G+G+ DAPVSGGV GA
Sbjct: 61 GDVVFGEHGLLSGDAAARRLQRIVDHSSIPPAATRDYAARATALGVGWVDAPVSGGVPGA 120
Query: 527 XNATLAFMAGGRKEDFE 577
TLA MAGGR D +
Sbjct: 121 QAGTLAVMAGGRAADLD 137
>UniRef50_A6EH53 Cluster: Putative uncharacterized protein; n=1;
Pedobacter sp. BAL39|Rep: Putative uncharacterized
protein - Pedobacter sp. BAL39
Length = 292
Score = 69.3 bits (162), Expect = 7e-11
Identities = 35/139 (25%), Positives = 67/139 (48%)
Frame = +2
Query: 158 FLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXSIL 337
++GLGNMG MA ++ KG+++ Y+ + G A + ++
Sbjct: 17 WIGLGNMGVPMAGQVLNKGYSLTVYNRTLSKTEPLVAQGAKVAGTPGELIAATDIVFLMV 76
Query: 338 TSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGV 517
+ + V ++ G DG+++ G ++++ ST+ P + ++ G+ + DAPVSG V
Sbjct: 77 SDDHAVASLFEGADGLLSKELHGKVIVNMSTVSPAISIKMAAACSAVGIEYLDAPVSGSV 136
Query: 518 MGAXNATLAFMAGGRKEDF 574
A + L M GG ++ F
Sbjct: 137 KQATDGQLVIMVGGEEQAF 155
>UniRef50_A5P0V0 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=3; Rhizobiales|Rep:
6-phosphogluconate dehydrogenase, NAD-binding precursor
- Methylobacterium sp. 4-46
Length = 299
Score = 69.3 bits (162), Expect = 7e-11
Identities = 48/145 (33%), Positives = 67/145 (46%), Gaps = 4/145 (2%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
VAF+GLG MG MA NLV KGF VRGYD ++ A A+ G A+++
Sbjct: 6 VAFVGLGAMGLPMAQNLVAKGFPVRGYDVRPESRAALARAGGEAADTLRAAAAGAGALVL 65
Query: 332 ILTSNKVVLDVYLG----KDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 499
++ + V G +G + + +I +T P + + G F DA
Sbjct: 66 MVVNAAQAEAVLFGGGAPAEGALEVLAPDAAVILMATCPPQAVEGLAARVAAAGRRFVDA 125
Query: 500 PVSGGVMGAXNATLAFMAGGRKEDF 574
PVSGGV+GA +L MA E F
Sbjct: 126 PVSGGVVGAEAGSLTVMAAAPAEVF 150
>UniRef50_A1ZWM5 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Microscilla marina ATCC 23134|Rep: 3-hydroxyisobutyrate
dehydrogenase - Microscilla marina ATCC 23134
Length = 295
Score = 69.3 bits (162), Expect = 7e-11
Identities = 46/136 (33%), Positives = 65/136 (47%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AF+GLG MG MA+NL+K + Y+ S A G A++ S
Sbjct: 3 IAFIGLGIMGSRMASNLLKHKVDLTVYNRSLAATTPLVALGAKVAHTTTEAVKEADIVFS 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L S +VV V G+ G ++ K +L ID STI P A + + F +APV+G
Sbjct: 63 MLASPQVVKAVAYGQTGFLSKMKSKALWIDCSTISPAFALASAQEASKHEVVFVEAPVAG 122
Query: 512 GVMGAXNATLAFMAGG 559
A NA L F+ GG
Sbjct: 123 TKSHAENAELVFLVGG 138
>UniRef50_Q98I20 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Alphaproteobacteria|Rep: 3-hydroxyisobutyrate
dehydrogenase - Rhizobium loti (Mesorhizobium loti)
Length = 305
Score = 68.9 bits (161), Expect = 1e-10
Identities = 41/145 (28%), Positives = 69/145 (47%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
++ AF+GLG++GG +A +L++ GF + +D A+ G T ANS
Sbjct: 3 ESYAFIGLGHLGGNLAPSLIRNGFAITVFDRDPAAVERLVTLGATAANSPAEAAARAGNA 62
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+ L S K+ V G G++ KG I+ ST + ++ +A +G+ + PV
Sbjct: 63 ITCLPSPKISEAVLAGPGGLLEGLPKGGTWIEMSTNGRDEIMRLAALASAEGVETLECPV 122
Query: 506 SGGVMGAXNATLAFMAGGRKEDFER 580
+GGV A + + GG +ER
Sbjct: 123 TGGVHLAAVGKITALVGGDAALYER 147
>UniRef50_Q47AR2 Cluster: NADP oxidoreductase, coenzyme
F420-dependent:6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Dechloromonas aromatica RCB|Rep: NADP
oxidoreductase, coenzyme
F420-dependent:6-phosphogluconate dehydrogenase,
NAD-binding - Dechloromonas aromatica (strain RCB)
Length = 287
Score = 68.5 bits (160), Expect = 1e-10
Identities = 49/148 (33%), Positives = 72/148 (48%), Gaps = 4/148 (2%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTV----RGYDPSKDALNAAAKNGVTPANSIXXXXXXXX 319
+ F+GLG MG MA NL+K G V R + + L+A AK +PA +
Sbjct: 3 IGFIGLGIMGRPMALNLIKGGHQVTVWARRAESMQPLLDAGAKGAASPAEA----ARGNE 58
Query: 320 XXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 499
S++ V +V G V + + G + +D STI P ++I G+ F DA
Sbjct: 59 LVISMVADAPDVAEVMRG---VASAGESGLVAVDMSTIAPAAARRIGEDLAAAGIDFIDA 115
Query: 500 PVSGGVMGAXNATLAFMAGGRKEDFERS 583
PVSGG +GA +L+ MAGG F ++
Sbjct: 116 PVSGGEVGAIAGSLSIMAGGSDAAFAKA 143
>UniRef50_A3X9R7 Cluster: 3-hydroxyisobutyrate dehydrogenase family
protein; n=2; Rhodobacterales|Rep: 3-hydroxyisobutyrate
dehydrogenase family protein - Roseobacter sp. MED193
Length = 300
Score = 68.5 bits (160), Expect = 1e-10
Identities = 40/143 (27%), Positives = 69/143 (48%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ +GLG MGG + L+ + + +D +A AA G A+S+ S
Sbjct: 17 IGLVGLGAMGGGYLSRLMAQNCDLMCFDAMPEARARAAAAGAKVADSLADFSACDTVILS 76
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+ ++ + + G + KKGS+++D+ST +P+ K++ A G F D PVSG
Sbjct: 77 L--PKAAIVSAVMEELG--PYLKKGSIVVDTSTSEPDTTKRLAAAAESNGYTFLDGPVSG 132
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
G +GA T+ + GG + F +
Sbjct: 133 GPLGARTGTMTMVVGGDEAGFTK 155
>UniRef50_Q94B07 Cluster: Gamma hydroxybutyrate dehydrogenase; n=16;
cellular organisms|Rep: Gamma hydroxybutyrate
dehydrogenase - Arabidopsis thaliana (Mouse-ear cress)
Length = 289
Score = 68.5 bits (160), Expect = 1e-10
Identities = 45/144 (31%), Positives = 64/144 (44%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V FLGLG MG M+ NL+K GF V ++ + + ++G + S +
Sbjct: 3 VGFLGLGIMGKAMSMNLLKNGFKVTVWNRTLSKCDELVEHGASVCESPAEVIKKCKYTIA 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L+ L V K GV+ +G ID ST+D +I KG F + PVSG
Sbjct: 63 MLSDPCAALSVVFDKGGVLEQICEGKGYIDMSTVDAETSLKINEAITGKGGRFVEGPVSG 122
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
A + L +A G K FE S
Sbjct: 123 SKKPAEDGQLIILAAGDKALFEES 146
>UniRef50_A5GPC0 Cluster: Hydroxyacid dehydrogenase/reductase family
protein; n=14; Cyanobacteria|Rep: Hydroxyacid
dehydrogenase/reductase family protein - Synechococcus
sp. (strain WH7803)
Length = 302
Score = 68.1 bits (159), Expect = 2e-10
Identities = 44/150 (29%), Positives = 76/150 (50%), Gaps = 6/150 (4%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AF+GLG +G +AANL + G++++ + S+ A N + + PA +
Sbjct: 12 LAFVGLGALGLPIAANLHRAGYSLQVHTRSRSAENDPSLHQGDPAAATLCCASPADAVQG 71
Query: 332 -----ILTSNKVVLDVYL-GKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 493
+ S+ ++ L G +G +GSL+ID STI P+ +++ +G+ +
Sbjct: 72 CQALVLCVSDDAAVEAVLWGDNGAGPALAEGSLVIDCSTISPSTSQRMARRLAHRGVRYL 131
Query: 494 DAPVSGGVMGAXNATLAFMAGGRKEDFERS 583
DAPV+GG GA TL + GG D +R+
Sbjct: 132 DAPVTGGTEGAKAGTLTVLCGGSDADLDRA 161
>UniRef50_P77161 Cluster: 2-hydroxy-3-oxopropionate reductase; n=99;
Proteobacteria|Rep: 2-hydroxy-3-oxopropionate reductase
- Escherichia coli (strain K12)
Length = 292
Score = 67.7 bits (158), Expect = 2e-10
Identities = 47/145 (32%), Positives = 66/145 (45%), Gaps = 2/145 (1%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFT--VRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ F+GLG MG MA NL + G V P D L + V A +
Sbjct: 3 LGFIGLGIMGTPMAINLARAGHQLHVTTIGPVADELLSLGAVSVETARQVTEASDIIFI- 61
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
++ V +V G++G + KG ++D S+I P K+ E G + DAPV
Sbjct: 62 --MVPDTPQVEEVLFGENGCTKASLKGKTIVDMSSISPIETKRFARQVNELGGDYLDAPV 119
Query: 506 SGGVMGAXNATLAFMAGGRKEDFER 580
SGG +GA TL+ M GG + FER
Sbjct: 120 SGGEIGAREGTLSIMVGGDEAVFER 144
>UniRef50_Q1IQE6 Cluster: 2-hydroxy-3-oxopropionate reductase
precursor; n=1; Acidobacteria bacterium Ellin345|Rep:
2-hydroxy-3-oxopropionate reductase precursor -
Acidobacteria bacterium (strain Ellin345)
Length = 282
Score = 67.3 bits (157), Expect = 3e-10
Identities = 49/144 (34%), Positives = 68/144 (47%), Gaps = 1/144 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPS-KDALNAAAKNGVTPANSIXXXXXXXXXXX 328
VAFLGLG MG MAANL K G V ++ + KD A TPA +
Sbjct: 3 VAFLGLGIMGRPMAANLAKAGNEVTVWNRTPKDVEGAHVAK--TPAEA----AKHADVVW 56
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
++ V V G GV + G +++DSSTI P + KG + DAP++
Sbjct: 57 MCVSDTNAVERVLFGDGGVEPVLRAGMVVVDSSTISPVETLKFAERVRAKGADYIDAPIT 116
Query: 509 GGVMGAXNATLAFMAGGRKEDFER 580
G +GA +A L FM G + E ++
Sbjct: 117 GSKIGAESAQLIFMVGAKDETLKK 140
>UniRef50_Q8EW87 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Mycoplasma penetrans|Rep: 3-hydroxyisobutyrate
dehydrogenase - Mycoplasma penetrans
Length = 288
Score = 66.9 bits (156), Expect = 4e-10
Identities = 41/144 (28%), Positives = 67/144 (46%), Gaps = 1/144 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ ++G G MG M L G + Y+ + + +N + SI +
Sbjct: 3 ITWIGTGIMGKAMLNRLASHGHIIHAYNRTYEKMNDLNHPNILKFRSIKDAVKDTNIIMT 62
Query: 332 ILTSNKVVLDVYLGKD-GVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
++ VLD+YL + G+ + + ID +T PN Q+ + KG+ DAPV+
Sbjct: 63 MVGYPSDVLDIYLNDEYGIFNYVSSEQICIDFTTSSPNFAVQLANNS--KGIKVLDAPVT 120
Query: 509 GGVMGAXNATLAFMAGGRKEDFER 580
GG +GA N TL+ M GG E F++
Sbjct: 121 GGDIGALNGTLSIMVGGDFETFKK 144
>UniRef50_Q606G9 Cluster: Oxidoreductase, Gfo/Idh/MocA family; n=6;
Proteobacteria|Rep: Oxidoreductase, Gfo/Idh/MocA family
- Methylococcus capsulatus
Length = 289
Score = 66.9 bits (156), Expect = 4e-10
Identities = 44/142 (30%), Positives = 71/142 (50%), Gaps = 1/142 (0%)
Frame = +2
Query: 158 FLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPA-NSIXXXXXXXXXXXSI 334
F+GLG MG MA NL + G ++ + + A A TPA ++ +
Sbjct: 5 FVGLGAMGLGMARNLRRAGLLAGVWNRTPEKARAFAAETGTPAWATLTEMAPACDVIVTC 64
Query: 335 LTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGG 514
++++ VL+V + + G++++D ST+ ++ + + G F DAPVSGG
Sbjct: 65 VSADADVLEVIAA---LTPGLRPGAVIVDCSTVGVATARRAAEVVRQAGGDFLDAPVSGG 121
Query: 515 VMGAXNATLAFMAGGRKEDFER 580
V GA + TLA M GGR E E+
Sbjct: 122 VEGARDGTLALMIGGRAETVEK 143
>UniRef50_A5VBF0 Cluster: 2-hydroxy-3-oxopropionate reductase
precursor; n=1; Sphingomonas wittichii RW1|Rep:
2-hydroxy-3-oxopropionate reductase precursor -
Sphingomonas wittichii RW1
Length = 298
Score = 66.5 bits (155), Expect = 5e-10
Identities = 47/146 (32%), Positives = 63/146 (43%), Gaps = 1/146 (0%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ +AFLG+G MG MAA L+ G + ++ S D L G
Sbjct: 3 QRMAFLGIGLMGRPMAARLLDSGHELALWNRSADKLAPLVAAGGRACAIPAEAVEGAAVV 62
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG-LGFTDAP 502
LT V V G+ G G+L++D STI P+ + E G + D P
Sbjct: 63 CLCLTDADAVEQVMFGEGGAARALAPGALVVDFSTIGPDATRGFAKRLAETGDAQWLDCP 122
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFER 580
VSGGV GA TLA +AGG +R
Sbjct: 123 VSGGVAGAEAGTLAILAGGDAAAIDR 148
>UniRef50_A1UJF2 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=6; Actinomycetales|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Mycobacterium sp. (strain KMS)
Length = 272
Score = 66.5 bits (155), Expect = 5e-10
Identities = 40/144 (27%), Positives = 64/144 (44%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V F+GLG+ GG MA +V+ G+ + + +L A A S
Sbjct: 3 VGFIGLGSQGGPMARRIVEGGYELTLWARRPASLEPYADTAAKTAGSPAELAAASDLVCV 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+ + V +V G GV+A G+++ ST+ P+ ++I A + + DAPVSG
Sbjct: 63 CVVGDDDVREVLYGDTGVLAGLAPGAMIAIHSTVHPDTCREIAEKAAAQNVSVIDAPVSG 122
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
G L M GG + D E++
Sbjct: 123 GAPAVEQGKLLVMVGGEEADVEKA 146
>UniRef50_A0R1N4 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Mycobacterium|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Mycobacterium smegmatis
(strain ATCC 700084 / mc(2)155)
Length = 272
Score = 66.1 bits (154), Expect = 7e-10
Identities = 42/139 (30%), Positives = 62/139 (44%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V F+GLG+ G MA +V+ GF + +L A A +
Sbjct: 3 VGFIGLGSQGAPMARRIVEGGFETTLWARRPASLEPFADTAAKVAGTPAELAAASDLVCL 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+ + V +V G+ GV+A G ++ ST+ P+ +I EKG+ DAPVSG
Sbjct: 63 CVVGDDDVREVLDGETGVLAGLAPGGIIAIHSTVHPDTCTEIAEQVAEKGISLIDAPVSG 122
Query: 512 GVMGAXNATLAFMAGGRKE 568
G A TL MAGG ++
Sbjct: 123 GEPAAKAGTLLVMAGGDED 141
>UniRef50_A4SWE8 Cluster: 2-hydroxy-3-oxopropionate reductase
precursor; n=7; Proteobacteria|Rep:
2-hydroxy-3-oxopropionate reductase precursor -
Polynucleobacter sp. QLW-P1DMWA-1
Length = 299
Score = 65.3 bits (152), Expect = 1e-09
Identities = 46/145 (31%), Positives = 67/145 (46%), Gaps = 3/145 (2%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSK---DALNAAAKNGVTPANSIXXXXXXXXX 322
+ F+GLG MG MA++L+ G + SK + N+AA TPA
Sbjct: 6 LGFIGLGIMGAPMASHLMAAGHALFINTRSKVPEELANSAAVVCATPAE----VAKMADI 61
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
+++ V V G+ GV KG +++D S+I P K G + DAP
Sbjct: 62 IFTMVPDTPDVEKVLFGEHGVAHGLSKGKIVVDMSSISPIATKDFAKKINALGCEYLDAP 121
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFE 577
VSGG +GA TL M GG++ F+
Sbjct: 122 VSGGQVGAKGGTLTIMVGGKESVFQ 146
>UniRef50_A4ECY9 Cluster: Putative uncharacterized protein; n=1;
Collinsella aerofaciens ATCC 25986|Rep: Putative
uncharacterized protein - Collinsella aerofaciens ATCC
25986
Length = 359
Score = 65.3 bits (152), Expect = 1e-09
Identities = 40/141 (28%), Positives = 66/141 (46%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
+VAF+G G MG +A +++ G+ V + +K A + G A +
Sbjct: 6 SVAFIGTGIMGAPIAGHILDAGYPVTVNNRTKSKAAALIERGAVWAETPADAVVNADVVF 65
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
+++ V ++YL DG++ K G++LID +T P + + I A G D PV+
Sbjct: 66 TMVGYPSEVEELYLAGDGLLTCTKPGAVLIDLTTSSPELARDIAEAAQVSGRMAFDCPVT 125
Query: 509 GGVMGAXNATLAFMAGGRKED 571
GG GA TL + G + D
Sbjct: 126 GGESGAIAGTLTAIVGATEND 146
>UniRef50_A0FZ96 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Burkholderia phymatum STM815|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Burkholderia phymatum STM815
Length = 305
Score = 65.3 bits (152), Expect = 1e-09
Identities = 40/144 (27%), Positives = 69/144 (47%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ ++GLG MGG +A +L+ K + + +D ++ A+ A + G T A +
Sbjct: 3 IGYIGLGAMGGALARHLIGK-YPLSVFDLNRKAVEAFVELGATAAATPAELARNSDVVLL 61
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L + V V G DG V G ++ID ++ P + + G+ DAPVSG
Sbjct: 62 CLPRSSDVHSVLFGPDGAVEGLSDGKIVIDQTSGVPAETRDFARQLADIGVALFDAPVSG 121
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
+ A T++ +A G K+ FE++
Sbjct: 122 AMATAIAGTISIIASGPKDAFEKT 145
>UniRef50_Q01QM2 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Solibacter usitatus Ellin6076|Rep: 3-hydroxyisobutyrate
dehydrogenase - Solibacter usitatus (strain Ellin6076)
Length = 298
Score = 64.9 bits (151), Expect = 2e-09
Identities = 44/146 (30%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAA--KNGVTPANSIXXXXXXXXX 322
N+ FLGLG MG MA NL++ G V + + D A + GV A
Sbjct: 3 NLGFLGLGLMGYPMARNLLRAGHNVAVWSHTSDKARKLADEEKGVFCATPRDVGAGADVV 62
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
+ + +V LG G++ + G++++D STI ++I K + F DAP
Sbjct: 63 FLCV-GDTAMAREVILGGQGLIQGLRAGAVVVDCSTIAVADSREIGAALKAKSVDFLDAP 121
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFER 580
V+G GA + L FM GG + F +
Sbjct: 122 VTGSTPGAESGNLTFMIGGDEAVFSK 147
>UniRef50_A0JXR2 Cluster: 2-hydroxy-3-oxopropionate reductase; n=2;
Arthrobacter|Rep: 2-hydroxy-3-oxopropionate reductase -
Arthrobacter sp. (strain FB24)
Length = 333
Score = 64.9 bits (151), Expect = 2e-09
Identities = 49/150 (32%), Positives = 71/150 (47%), Gaps = 5/150 (3%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
K F+GLG MGG MAANL+K G+ V G++ S AL+ A G A +
Sbjct: 16 KRAGFVGLGLMGGPMAANLLKAGWNVTGWNRSAAALDDLAARGGMRAADVASLRDEPVII 75
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAK--KGSLLIDSSTIDPNVPKQ--IFPIALEKGLG-F 490
+L + D G A G++++ S++ P + + A +G
Sbjct: 76 F-MLPDLSYIEDAAAGLLAGWADEPPGPGTVVVVMSSVSPAAVRDFGVKVSAASRGNAVV 134
Query: 491 TDAPVSGGVMGAXNATLAFMAGGRKEDFER 580
DAPVSGG GA + TLA M G ++DF+R
Sbjct: 135 VDAPVSGGTKGAEDGTLAIMVGAGEQDFQR 164
>UniRef50_Q6UCZ9 Cluster: Predicted oxidoreductase; n=2;
environmental samples|Rep: Predicted oxidoreductase -
uncultured marine proteobacterium ANT32C12
Length = 309
Score = 64.5 bits (150), Expect = 2e-09
Identities = 39/143 (27%), Positives = 72/143 (50%), Gaps = 1/143 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKN-GVTPANSIXXXXXXXXXXX 328
+ F+GLG MG MA +L K+ + ++ S++ + T ++
Sbjct: 23 IGFIGLGVMGYPMAGHLSKEFSNICIFNRSQEKVTKWLNQYSGTAFDTPEELSSQCNVIA 82
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
+ ++ V ++ GK G++ G+++ID +T + K++ +AL+K + F DAP+S
Sbjct: 83 LCVGRDEDVREMMSGKKGILNSVNPGTIIIDHTTTSATLSKEMNELALQKDVIFLDAPIS 142
Query: 509 GGVMGAXNATLAFMAGGRKEDFE 577
GG GA + L+ M GG K +E
Sbjct: 143 GGQAGAESGQLSVMVGGDKASYE 165
>UniRef50_Q0FFH2 Cluster: Putative 2-hydroxyacid dehydrogenase; n=2;
Alphaproteobacteria|Rep: Putative 2-hydroxyacid
dehydrogenase - alpha proteobacterium HTCC2255
Length = 303
Score = 64.5 bits (150), Expect = 2e-09
Identities = 37/143 (25%), Positives = 66/143 (46%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG MGG + NL++ G + D + G A++ +
Sbjct: 3 IGFIGLGTMGGAASLNLIRGGHQLTVCDLDLKRATKHLELGAKWADTPSEAAKDVDIVFT 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
++ K + + G++G++ G + +D +T P + +++ ++ G DAPV+G
Sbjct: 63 MVFGPKQIEQIIRGENGLLHSMGPGQVWVDLTTNQPELARELAQEIIDTGAIAIDAPVTG 122
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
V GA N + AGG KE ER
Sbjct: 123 AVDGARNGNMTQFAGGDKETIER 145
>UniRef50_A5FTT0 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Alphaproteobacteria|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Acidiphilium cryptum (strain JF-5)
Length = 305
Score = 64.1 bits (149), Expect = 3e-09
Identities = 49/147 (33%), Positives = 68/147 (46%), Gaps = 1/147 (0%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKN-GVTPANSIXXXXXXXXX 322
+ VAF+GLGNMG MAA LV G V G D + A A+ G T A
Sbjct: 3 QRVAFIGLGNMGWPMAARLVGGGCEVTGCDAVEGRAEAFAREVGGTAAADADAAARGAEF 62
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
++L ++ +V V + G+LLI+ S+ P V ++I + DAP
Sbjct: 63 IVTMLPNSALVESVVAAMRPSLG---AGALLIEMSSGIPGVTRRIAAGLEAAKVAMIDAP 119
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFERS 583
VSGGV A L+ M GG +D R+
Sbjct: 120 VSGGVARAKTGDLSIMTGGSADDCARA 146
>UniRef50_A2C1U6 Cluster: 3-hydroxyisobutyrate dehydrogenase and
related beta-hydroxyacid dehydrogenases; n=2;
Prochlorococcus marinus|Rep: 3-hydroxyisobutyrate
dehydrogenase and related beta-hydroxyacid
dehydrogenases - Prochlorococcus marinus (strain NATL1A)
Length = 287
Score = 64.1 bits (149), Expect = 3e-09
Identities = 41/140 (29%), Positives = 65/140 (46%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AF+GLG +G M+ L+ G+ + Y +K ++ K P ++
Sbjct: 3 LAFIGLGAIGKPMSQRLIDNGYDLNLYQRNKLNNDSKRKYFFDPIEAVSDCDGLLI---- 58
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+T + V V G +GV K S +ID STI P+ I E+ + + D PVSG
Sbjct: 59 CVTDDNAVESVLFGDNGVSGSLKPNSFVIDFSTISPDKSISIHKRLGEQNIFYVDCPVSG 118
Query: 512 GVMGAXNATLAFMAGGRKED 571
G GA N +L+ G ++D
Sbjct: 119 GTEGAHNGSLSLFIGASEKD 138
>UniRef50_Q1EPJ1 Cluster: 6-phosphogluconate dehydrogenase
NAD-binding domain-containing protein; n=8;
Magnoliophyta|Rep: 6-phosphogluconate dehydrogenase
NAD-binding domain-containing protein - Musa acuminata
(Banana)
Length = 314
Score = 64.1 bits (149), Expect = 3e-09
Identities = 46/140 (32%), Positives = 68/140 (48%), Gaps = 4/140 (2%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGY--DPSK-DALNAAAKNGV-TPANSIXXXXXXXX 319
V ++G G MG MAA L G+ V Y PSK D L + V +PA++
Sbjct: 18 VGWIGAGVMGAAMAARLQTAGYAVAIYARTPSKADHLRRLGAHLVPSPADAARSADVLFT 77
Query: 320 XXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 499
+ +LD G +A G +L+D ++ DP + +++ A +G DA
Sbjct: 78 MVGHPFDVREALLDP---ASGALAAIPPGGVLVDCTSSDPALAREVAAAARARGCWAVDA 134
Query: 500 PVSGGVMGAXNATLAFMAGG 559
PVSGG +GA + TLA +AGG
Sbjct: 135 PVSGGDVGARDGTLAILAGG 154
>UniRef50_Q121N3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=19;
Burkholderiales|Rep: 3-hydroxyisobutyrate dehydrogenase
- Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 298
Score = 63.7 bits (148), Expect = 4e-09
Identities = 38/145 (26%), Positives = 62/145 (42%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
NV +GLG MG +A L G+ V YD A+ G +++
Sbjct: 5 NVGVIGLGAMGRGIAQTLRSAGYAVHVYDVRAQAVQEFVAAGGVACDTLTQLAAACEVVV 64
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
S++ + DV + GV + K GS+ + ST+DP + G+ + DAP+S
Sbjct: 65 SVVVNAAQTEDVLWSEQGVASAMKSGSVFVMCSTVDPQWSIATEARLDKLGIHYVDAPIS 124
Query: 509 GGVMGAXNATLAFMAGGRKEDFERS 583
GG A + M+ R +E++
Sbjct: 125 GGAAKAAAGQMTVMSSARPAAYEKA 149
>UniRef50_P71825 Cluster: Uncharacterized oxidoreductase
Rv0770/MT0794; n=18; Corynebacterineae|Rep:
Uncharacterized oxidoreductase Rv0770/MT0794 -
Mycobacterium tuberculosis
Length = 295
Score = 63.7 bits (148), Expect = 4e-09
Identities = 40/143 (27%), Positives = 62/143 (43%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ ++GLGN G MA L+ + +D +A+ + G T A S+ +
Sbjct: 10 LGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAPFVEGGATAAASVSDVAEADIISIT 69
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+ +V V +G+ HAK G+++ STI + +G+ DAPVSG
Sbjct: 70 VFDDAQVS-SVITADNGLATHAKPGTIVAIHSTIADTTAVDLAEKLKPQGIHIVDAPVSG 128
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
G A LA M G E F+R
Sbjct: 129 GAAAAAKGELAVMVGADDEAFQR 151
>UniRef50_Q89M84 Cluster: Blr4309 protein; n=6;
Bradyrhizobiaceae|Rep: Blr4309 protein - Bradyrhizobium
japonicum
Length = 293
Score = 63.3 bits (147), Expect = 5e-09
Identities = 41/144 (28%), Positives = 64/144 (44%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
VAF+GLG MG MA + GFTV ++ SK G A S +
Sbjct: 4 VAFIGLGRMGHGMAGRYLDAGFTVTLWNRSKTKAEDLIARGAHWATSPEDAAIDADAVVT 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
++ ++ V+LG G AK G++ I+ ST+ + +++ +GL + D PV+G
Sbjct: 64 MVADDEASRAVWLGPKGAAKTAKAGTIAIECSTVSYDHAREMGRELNARGLIYIDCPVTG 123
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
A L + G D ER+
Sbjct: 124 LPDAAAAGKLTLLVGADAADLERA 147
>UniRef50_Q0KC92 Cluster: 3-Hydroxyisobutyrate dehydrogenase; n=1;
Ralstonia eutropha H16|Rep: 3-Hydroxyisobutyrate
dehydrogenase - Ralstonia eutropha (strain ATCC 17699 /
H16 / DSM 428 / Stanier 337)(Cupriavidus necator (strain
ATCC 17699 / H16 / DSM 428 / Stanier337))
Length = 305
Score = 63.3 bits (147), Expect = 5e-09
Identities = 37/142 (26%), Positives = 62/142 (43%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ ++G+G MG M NL+K G+ + +D A A G A + S
Sbjct: 15 LGWIGVGAMGRPMCLNLLKAGYRLTVFDRVPAQCEAVAAAGAAVAPAAQALVADSDVVFS 74
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+ + + D++L GV A + +D ST+ P+ ++ +G F APVSG
Sbjct: 75 TIFDDGGLRDLFLASGGVAGAATADKVFVDMSTVSPDASAEVAAALARRGAAFLRAPVSG 134
Query: 512 GVMGAXNATLAFMAGGRKEDFE 577
V A +A L+ G + F+
Sbjct: 135 TVSLAASAQLSCFVSGPRPAFD 156
>UniRef50_UPI0001597301 Cluster: YfjR; n=1; Bacillus
amyloliquefaciens FZB42|Rep: YfjR - Bacillus
amyloliquefaciens FZB42
Length = 286
Score = 62.9 bits (146), Expect = 6e-09
Identities = 39/139 (28%), Positives = 63/139 (45%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+A +GLGNMG +A N++K G+++ Y+ +K+ G A + S
Sbjct: 3 IAIVGLGNMGRPIAENIMKAGYSLTVYNRTKEKAADLLDKGAEYAETPRQAAEHADIVLS 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L+ + V DV G G++A + + I STI + +Q+ +G F APV G
Sbjct: 63 MLSDDDAVTDVTFGACGIIAGLSENGIHISMSTISTALSEQLSAAHSGRGQSFIAAPVLG 122
Query: 512 GVMGAXNATLAFMAGGRKE 568
A A L + G E
Sbjct: 123 RPDAAEKAELRIITAGPAE 141
>UniRef50_A6G049 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Plesiocystis pacifica SIR-1|Rep: 3-hydroxyisobutyrate
dehydrogenase - Plesiocystis pacifica SIR-1
Length = 307
Score = 62.9 bits (146), Expect = 6e-09
Identities = 43/155 (27%), Positives = 65/155 (41%), Gaps = 11/155 (7%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAK-----------NGVTPANSIX 298
+AFLG G MG M NL G +R Y+ +K AAA V +
Sbjct: 4 IAFLGTGTMGAGMVRNLAAAGHELRIYNRTKSRAEAAADVVADTVDLSSGGSVRVVDEPV 63
Query: 299 XXXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEK 478
+ + S+ V LG+ G +A +G+L+ID T + +Q+ +
Sbjct: 64 YAARGAEFIIACVGSDAATFAVLLGEGGALAGVGQGALVIDCGTTSLKLTEQLAAACEGE 123
Query: 479 GLGFTDAPVSGGVMGAXNATLAFMAGGRKEDFERS 583
G F DAP++G +GA L M G +E R+
Sbjct: 124 GASFLDAPITGSKLGAEGGKLTIMVAGEEEIVARA 158
>UniRef50_Q3W9W7 Cluster: 6-phosphogluconate dehydrogenase, NAD
binding domain; n=2; Frankia sp. EAN1pec|Rep:
6-phosphogluconate dehydrogenase, NAD binding domain -
Frankia sp. EAN1pec
Length = 286
Score = 62.5 bits (145), Expect = 9e-09
Identities = 41/140 (29%), Positives = 68/140 (48%)
Frame = +2
Query: 140 TDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXX 319
T +V F+GLGNMGG +AAN+ + G + +D + A G T + +
Sbjct: 2 TAPSVGFVGLGNMGGALAANVAQFGLDLVVHDAAGPE---RAPEGTTHLDDLAAVARHAE 58
Query: 320 XXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 499
+L+ V+ + + ++ + ++D+STI + ++I + G+G+ DA
Sbjct: 59 VV--VLSLPDGVISEKVARGLAETADRRVTHVVDTSTIGVSAAQRITDLLAASGIGYVDA 116
Query: 500 PVSGGVMGAXNATLAFMAGG 559
PVSGGV GA TL M G
Sbjct: 117 PVSGGVTGARARTLTVMYAG 136
>UniRef50_Q13PY3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Burkholderiales|Rep: 3-hydroxyisobutyrate dehydrogenase
- Burkholderia xenovorans (strain LB400)
Length = 302
Score = 62.1 bits (144), Expect = 1e-08
Identities = 42/142 (29%), Positives = 59/142 (41%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ +GLGN+G A L+ G + YD +A+ G A
Sbjct: 3 IGLIGLGNIGQHFATRLLAAGHPLVVYDTRDEAMQRFGALGAELAKDTVDLASRAEVVFL 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L VV +V G GV + +++D ST P+V I ++ + F APVSG
Sbjct: 63 SLPLPSVVEEVATGPHGV-SQGSSVRIVVDLSTTGPSVSNVIARKLADRHIQFLGAPVSG 121
Query: 512 GVMGAXNATLAFMAGGRKEDFE 577
G + A TL MA G E FE
Sbjct: 122 GTVAAEKGTLTVMAAGPMEAFE 143
>UniRef50_Q0URA2 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 325
Score = 62.1 bits (144), Expect = 1e-08
Identities = 56/164 (34%), Positives = 78/164 (47%), Gaps = 19/164 (11%)
Frame = +2
Query: 134 SNTDKNVAFLGLGNMGGFMAANLVK---KGFTVRGYDPSKDALNAAAKN--GVTPANSIX 298
S +K VAF+GLG MG MA NL K T+ D S DAL + G P +++
Sbjct: 2 SPPEKTVAFIGLGVMGYPMALNLRKGLDDSHTLLVCDVSSDALARFQNDAKGHGPVSTVD 61
Query: 299 XXXXXXXXXXSILT---SNKVVLDVYLGKD-GVVAHAKKGS------LLIDSSTIDPN-- 442
+++T + V VYL G++A A+ S L+++ TI+ +
Sbjct: 62 GGYQAVQLADTVITMLPDSNAVKKVYLDPSTGILAGAEANSGTKSDKLIMECGTIETSTI 121
Query: 443 --VPKQIFPIALEKGLGFTDAPVSGGVMGAXNATLAFMAGGRKE 568
V K + L F DAPVSGG MGA + TLAFMAG +
Sbjct: 122 LEVAKATSSSKAAENLTFVDAPVSGGPMGAQDGTLAFMAGANNK 165
>UniRef50_Q74D68 Cluster: 3-hydroxyisobutyrate dehydrogenase family
protein; n=7; Desulfuromonadales|Rep:
3-hydroxyisobutyrate dehydrogenase family protein -
Geobacter sulfurreducens
Length = 288
Score = 61.7 bits (143), Expect = 1e-08
Identities = 42/138 (30%), Positives = 60/138 (43%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ V FLGLG +G MAANL+K + + YD A+ A G T A +
Sbjct: 3 RKVGFLGLGTVGRHMAANLLKGNYELAVYDSDPAAVADLAALGATGAATPREVAKGRDIV 62
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
I + + G DG+ A G++L+D T ++ A + + F DAPV
Sbjct: 63 IHIRPEKERLRPDIYGPDGIFAGIDPGTILVDMGTHSLTSTMEMADEAAKHRVMFLDAPV 122
Query: 506 SGGVMGAXNATLAFMAGG 559
G A N L +AGG
Sbjct: 123 WGTKEHAANGLLTILAGG 140
>UniRef50_Q9LM23 Cluster: Fructose-bisphosphate aldolase; n=2;
Arabidopsis thaliana|Rep: Fructose-bisphosphate aldolase
- Arabidopsis thaliana (Mouse-ear cress)
Length = 1486
Score = 61.7 bits (143), Expect = 1e-08
Identities = 52/151 (34%), Positives = 66/151 (43%), Gaps = 12/151 (7%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPS---------KDALNAAAKNGVTPANSIXXX 304
+ F+GLG MG MAA+L+K F+V GYD S K L G ANS
Sbjct: 348 IGFIGLGAMGFGMAAHLLKSNFSVCGYDISLRLAVSSVYKPTLVRFENAGGLAANSPAEV 407
Query: 305 XXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALE--- 475
++T+ DV G G V G+ ++ +ST+ P Q+ LE
Sbjct: 408 TKDVDVLVIMVTNEVQAEDVLYGHLGAVEAIPSGATVVLASTVSPAFVSQL-ERRLENEG 466
Query: 476 KGLGFTDAPVSGGVMGAXNATLAFMAGGRKE 568
K L DAPVSGGV A L MA G E
Sbjct: 467 KDLKLVDAPVSGGVKRAAMGELTIMASGTDE 497
Score = 32.7 bits (71), Expect = 7.9
Identities = 18/79 (22%), Positives = 37/79 (46%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V F+GL + +A++L++ GF V+ ++ S + + + G +S
Sbjct: 5 VGFVGLDSFSFELASSLLRSGFKVQAFEISTELVEKFIELGGHKCDSPADVGKAAAAVVV 64
Query: 332 ILTSNKVVLDVYLGKDGVV 388
+L+ + DV G +GV+
Sbjct: 65 VLSHPDQIQDVIFGDEGVM 83
>UniRef50_A7H7Z5 Cluster: 6-phosphogluconate dehydrogenase
NAD-binding; n=2; Anaeromyxobacter|Rep:
6-phosphogluconate dehydrogenase NAD-binding -
Anaeromyxobacter sp. Fw109-5
Length = 293
Score = 61.3 bits (142), Expect = 2e-08
Identities = 46/146 (31%), Positives = 65/146 (44%), Gaps = 2/146 (1%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKG--FTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ F+GLG +G +A NL K G TV PSK A + +K G A S
Sbjct: 5 IGFVGLGTIGEPIANNLRKAGHDLTVWNRTPSK-AAHIVSKGGKL-AGSARECATGRDLV 62
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+ ++ K + V G DGV+ + G +L+D ST + + A +G GF PV
Sbjct: 63 ITCVSDEKALDTVLEGPDGVLEALRDGDVLVDMSTAGVRAARSVSERAAARGAGFVACPV 122
Query: 506 SGGVMGAXNATLAFMAGGRKEDFERS 583
G A A L +AGG ER+
Sbjct: 123 LGSRSAAEQAQLVLVAGGPAVARERA 148
>UniRef50_A6R0U9 Cluster: Predicted protein; n=1; Ajellomyces
capsulatus NAm1|Rep: Predicted protein - Ajellomyces
capsulatus NAm1
Length = 444
Score = 61.3 bits (142), Expect = 2e-08
Identities = 46/146 (31%), Positives = 70/146 (47%), Gaps = 6/146 (4%)
Frame = +2
Query: 140 TDK-NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXX 316
T+K ++ F+GLG MG MA NL+K G+ V+GYD + + G A+S
Sbjct: 3 TEKPSIGFVGLGLMGFGMATNLIKLGYVVKGYDIQETTMARFKDAGGQIASSPGGAAGGN 62
Query: 317 XX-XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTID----PNVPKQIFPIALEKG 481
+ T+ + + ++ ++G+ G+ LI ST+ + Q+ I E
Sbjct: 63 MFCVCMVATAAQAQVAIFDHENGIAKGLPSGATLILCSTVSAVSAQSYRDQLVSIGRE-D 121
Query: 482 LGFTDAPVSGGVMGAXNATLAFMAGG 559
+ F DAPVSGG A TL MAGG
Sbjct: 122 VYFIDAPVSGGARKAGEGTLTIMAGG 147
>UniRef50_Q3W3N3 Cluster: Putative uncharacterized protein; n=1;
Frankia sp. EAN1pec|Rep: Putative uncharacterized
protein - Frankia sp. EAN1pec
Length = 315
Score = 60.9 bits (141), Expect = 3e-08
Identities = 40/156 (25%), Positives = 65/156 (41%)
Frame = +2
Query: 113 AARRAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANS 292
AA + SS ++ F+GLG+ G + G + YD D G++ A +
Sbjct: 3 AAPQGDSSLANETYGFVGLGHQGSQIVRRCASAGRHLVVYDTQTDRAEQFRPAGMSVAGT 62
Query: 293 IXXXXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIAL 472
+ + S++ V V G G++ + GSL++ ST P + A
Sbjct: 63 LAELGRRVTVASVCVYSDEDVRTVVAGPGGLLETMRSGSLVVIHSTCSPRTCVDLAARAR 122
Query: 473 EKGLGFTDAPVSGGVMGAXNATLAFMAGGRKEDFER 580
+G+ DAPVS G L +AGG + D +R
Sbjct: 123 GRGITVLDAPVSNGAPDESGRQLVVLAGGDRRDVDR 158
>UniRef50_A6VLT0 Cluster: 2-hydroxy-3-oxopropionate reductase; n=2;
Pasteurellaceae|Rep: 2-hydroxy-3-oxopropionate reductase
- Actinobacillus succinogenes 130Z
Length = 289
Score = 60.9 bits (141), Expect = 3e-08
Identities = 40/145 (27%), Positives = 73/145 (50%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ V ++GLG MG MAA+L++ G V Y+ + + A G + +S+
Sbjct: 7 REVGWIGLGQMGEPMAAHLLEHGVKVGVYNRTAEKCQNVAAKGASVYSSVLELVKAYDVI 66
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
++ ++ V++ L ++ V A KG L+++ ST+ P +Q+ + + G F +APV
Sbjct: 67 F-VMVADFPVIESLLSEE--VLTALKGKLVVNMSTVSPTQNQQLEFLLAKHGAEFIEAPV 123
Query: 506 SGGVMGAXNATLAFMAGGRKEDFER 580
SG A L +A G++E E+
Sbjct: 124 SGSSKVAEAGKLLVLAAGKEEIVEQ 148
>UniRef50_Q019Z7 Cluster: Oxidoreductase-like; n=1; Ostreococcus
tauri|Rep: Oxidoreductase-like - Ostreococcus tauri
Length = 325
Score = 60.9 bits (141), Expect = 3e-08
Identities = 48/186 (25%), Positives = 79/186 (42%), Gaps = 3/186 (1%)
Frame = +2
Query: 11 SCSGARAHGRTLN*EKNKFKMAARTILSTQCLYTAARRAYS--SNTDKNVAFLGLGNMGG 184
SC+ A +H RT + R + + RA + ++T +AFLG G MG
Sbjct: 2 SCASALSHART------SIVLGRRNTVHAHRRSSVVSRATTEKTSTPMKLAFLGCGIMGV 55
Query: 185 FMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXSILTSNKVVLDV 364
MA NL+ G V ++ ++ A + G T A + ++++ + L V
Sbjct: 56 PMAKNLIAAGHDVTVWNRTESATKPVVEAGATLAKTASEAARAADVVFVMVSTPEAALAV 115
Query: 365 -YLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAXNATL 541
+ K+G+ G +D ST+D + I + G F +APVSG A + L
Sbjct: 116 AHAAKEGL----SSGKGYVDVSTVDAGTSRAIAEVVRSTGAEFLEAPVSGSKKPAEDGAL 171
Query: 542 AFMAGG 559
F+ G
Sbjct: 172 IFLCAG 177
>UniRef50_Q7NR40 Cluster: Probable 3-hydroxyisobutyrate
dehydrogenase; n=1; Chromobacterium violaceum|Rep:
Probable 3-hydroxyisobutyrate dehydrogenase -
Chromobacterium violaceum
Length = 296
Score = 60.5 bits (140), Expect = 3e-08
Identities = 41/151 (27%), Positives = 67/151 (44%), Gaps = 4/151 (2%)
Frame = +2
Query: 137 NTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDAL----NAAAKNGVTPANSIXXX 304
N K +A +G G MG + L+ G+ VR Y+ S + +A A TPA ++
Sbjct: 5 NAGKRLALIGCGAMGTALGLRLLGLGWEVRVYNRSPERTAPLRDAGASAHATPAEAVAGA 64
Query: 305 XXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGL 484
++LT + + + G +G+ + G L+D T P + A G
Sbjct: 65 DWVA----TVLTDSAALRALLFGDNGIASAPAAGRRLVDLGTHQPTQLAALGAEAAAAGW 120
Query: 485 GFTDAPVSGGVMGAXNATLAFMAGGRKEDFE 577
+AP++G V A + TL F+ GG + D E
Sbjct: 121 PLVEAPMTGSVHDASHGTLHFLVGGAEADVE 151
>UniRef50_Q13LQ9 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=11;
Proteobacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Burkholderia xenovorans (strain LB400)
Length = 296
Score = 60.1 bits (139), Expect = 5e-08
Identities = 48/151 (31%), Positives = 70/151 (46%), Gaps = 6/151 (3%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNA---AAKNGVTPANSIXXXXXXX 316
K V F+GLG MG M L K GF + + DA A A ++G N+
Sbjct: 5 KRVGFIGLGMMGAPMVQCLRKAGFEL--FIDDADAARADTLAEQSGSHRLNA--DNAGSL 60
Query: 317 XXXXSILTSNKVVLDVYLG---KDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLG 487
++L ++ +V V LG G A KG+++ID S+ +P + + + L
Sbjct: 61 DALITMLPNSAIVEAVVLGDGNNTGWAARLAKGAVVIDMSSSEPERSRALGKTLEAQRLA 120
Query: 488 FTDAPVSGGVMGAXNATLAFMAGGRKEDFER 580
+ DAPVSGGV A TLA + GG + R
Sbjct: 121 YLDAPVSGGVKRAKEGTLAILVGGHADVLAR 151
>UniRef50_A6VYD9 Cluster: 2-hydroxy-3-oxopropionate reductase
precursor; n=5; Gammaproteobacteria|Rep:
2-hydroxy-3-oxopropionate reductase precursor -
Marinomonas sp. MWYL1
Length = 300
Score = 60.1 bits (139), Expect = 5e-08
Identities = 43/149 (28%), Positives = 62/149 (41%)
Frame = +2
Query: 134 SNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXX 313
+N K+V +GLG+MG A + + G V G+D + AL G S
Sbjct: 2 TNKAKSVGVIGLGSMGMGAAKSCINAGLDVYGFDLNPKALEELNLAGAKAVASSALDFAD 61
Query: 314 XXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 493
+L N ++ L G+ A K + ++ S+TI K I + L
Sbjct: 62 QLDAVLVLVVNAKQVNSVLFDSGLAAALKPQTAVMVSATISAEDAKAIHQKLSQYQLLML 121
Query: 494 DAPVSGGVMGAXNATLAFMAGGRKEDFER 580
DAPVSGG A + MA G E FE+
Sbjct: 122 DAPVSGGAAKAATGDMTVMASGSVEAFEK 150
>UniRef50_A1GFG2 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Salinispora arenicola CNS205|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Salinispora arenicola CNS205
Length = 315
Score = 60.1 bits (139), Expect = 5e-08
Identities = 38/139 (27%), Positives = 61/139 (43%), Gaps = 2/139 (1%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKG-FTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
++ LGLG MG M L+ G + ++ + +A + G A +
Sbjct: 2 HITMLGLGAMGSRMTRRLIATGEHDITVWNRTAEATRPLVEAGAVAAPTPAAATAQSDLV 61
Query: 326 XSILTSNKVVLDVYLGKD-GVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
S+L + V+L D G + G+L +D ST+ P +++ ++G F DAP
Sbjct: 62 ISMLRDVEAGRSVWLDPDVGALTSLAPGTLAVDCSTVTPTFSRELAACCAQRGAEFLDAP 121
Query: 503 VSGGVMGAXNATLAFMAGG 559
V G A TL F+AGG
Sbjct: 122 VLGSRPQADAGTLIFLAGG 140
>UniRef50_Q3W9L4 Cluster: Putative uncharacterized protein; n=1;
Frankia sp. EAN1pec|Rep: Putative uncharacterized
protein - Frankia sp. EAN1pec
Length = 294
Score = 59.3 bits (137), Expect = 8e-08
Identities = 42/144 (29%), Positives = 66/144 (45%), Gaps = 1/144 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V F+GLG+ GG MA + +G+ + + ++ A + GV S
Sbjct: 18 VGFIGLGSQGGPMARRIADEGYPLTIW--ARRAASVEPLAGVAAVASTPAEVGESSDVVG 75
Query: 332 I-LTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
I + ++ V DV L DGV+A G +++ STI P +++ A ++ + DAPVS
Sbjct: 76 ICVVADADVEDVLLRADGVLAGMAAGGVVVIHSTIRPETCQRLATEAAKQEISIIDAPVS 135
Query: 509 GGVMGAXNATLAFMAGGRKEDFER 580
GG A L M GG + R
Sbjct: 136 GGGDAAAQRRLLVMVGGEDDAVAR 159
>UniRef50_Q20XN2 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Rhodopseudomonas palustris BisB18|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Rhodopseudomonas palustris (strain BisB18)
Length = 365
Score = 59.3 bits (137), Expect = 8e-08
Identities = 42/136 (30%), Positives = 62/136 (45%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V +GLG MG A NL+ G + +D + ++A A+ GV A + S
Sbjct: 23 VGVVGLGRMGRAFAENLLADGHPIVVWDAFQTQIDAMARPGVVAATKLADLAECDVVFSS 82
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L ++ V V G G+V K G++ I STI P + +++ E G G+ APV G
Sbjct: 83 -LPDDEAVTAVAAGAGGLVKIMKAGAVHISMSTISPTMSRRLAAWHGECGQGYVAAPVLG 141
Query: 512 GVMGAXNATLAFMAGG 559
A TL +A G
Sbjct: 142 NPDLARARTLFILAAG 157
>UniRef50_A0JRK4 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=3; Actinomycetales|Rep:
6-phosphogluconate dehydrogenase, NAD-binding precursor
- Arthrobacter sp. (strain FB24)
Length = 299
Score = 59.3 bits (137), Expect = 8e-08
Identities = 42/145 (28%), Positives = 68/145 (46%), Gaps = 1/145 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ LGLG MG MA L + TV G+D ++ L A + G+ S
Sbjct: 7 ITVLGLGAMGLPMATRLASQ-LTVHGFDIAEPRLKLAEEAGIRTFASAREASEGADALLL 65
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPN-VPKQIFPIALEKGLGFTDAPVS 508
+ + + + DV G +GV + K G+++I ST+ + +P + +A E G+ DAP+S
Sbjct: 66 AVRNGEQLNDVLFGANGVASVLKPGAVVILGSTVGTDAIPATVDRLA-EYGVELVDAPLS 124
Query: 509 GGVMGAXNATLAFMAGGRKEDFERS 583
GG A L + G E E++
Sbjct: 125 GGPKRAGEGDLLIVVGASPEAQEKA 149
>UniRef50_Q656T5 Cluster: Oxidoreductase-like; n=3; Oryza
sativa|Rep: Oxidoreductase-like - Oryza sativa subsp.
japonica (Rice)
Length = 341
Score = 59.3 bits (137), Expect = 8e-08
Identities = 43/168 (25%), Positives = 68/168 (40%)
Frame = +2
Query: 77 ARTILSTQCLYTAARRAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALN 256
AR + S C +++ + V FLGLG MG MA+NL+ G V ++ ++ +
Sbjct: 30 ARLVFS--CSASSSSPSGEGGFSGKVGFLGLGIMGAPMASNLINAGCDVTVWNRTRSKCD 87
Query: 257 AAAKNGVTPANSIXXXXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTID 436
G S ++L + ++V G +G G +D ST+D
Sbjct: 88 PLLSLGAKYEPSPADVASSCDVTFAMLADPESAVEVACGANGAAQGMAPGKGYVDVSTVD 147
Query: 437 PNVPKQIFPIALEKGLGFTDAPVSGGVMGAXNATLAFMAGGRKEDFER 580
K I G F +APVSG A + L F+ G + + R
Sbjct: 148 AATSKLIGKHITSTGASFLEAPVSGSKKPAEDGLLIFLTAGDESLYNR 195
>UniRef50_A3Y8R5 Cluster: Putative dehydrogenase; n=1; Marinomonas
sp. MED121|Rep: Putative dehydrogenase - Marinomonas sp.
MED121
Length = 297
Score = 58.8 bits (136), Expect = 1e-07
Identities = 39/139 (28%), Positives = 70/139 (50%), Gaps = 4/139 (2%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVK----KGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXX 319
+ F+GLGNMG MAANL++ + D +++ ++ G A+S+
Sbjct: 3 IGFIGLGNMGSGMAANLLEYCKANHNELLVLDLNQEVVSQFVDKGARKADSVKHVAQECD 62
Query: 320 XXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 499
+ L S+ V + G++G++ +A+ G+ ++ST + + +++ IA L DA
Sbjct: 63 VIFTSLPSSVQVNHIAFGEEGILENAQAGATWFETSTNELSEWEKVKAIA-PSHLSLIDA 121
Query: 500 PVSGGVMGAXNATLAFMAG 556
PV+GG GA TL + G
Sbjct: 122 PVTGGAEGAAAGTLTMLLG 140
>UniRef50_A0LDJ3 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Magnetococcus sp. MC-1|Rep: 3-hydroxyisobutyrate
dehydrogenase - Magnetococcus sp. (strain MC-1)
Length = 292
Score = 58.8 bits (136), Expect = 1e-07
Identities = 37/145 (25%), Positives = 63/145 (43%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ + F+GLG MG MA + G+ + Y+ L + A +
Sbjct: 2 QKIGFIGLGIMGSAMANSCHHAGYQLCVYNRGHARLKPFIDRSIPTAATPQALATQSDYM 61
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
+++ +L+V G GV + G ++I++ST+ +Q + + G F DAPV
Sbjct: 62 VIMVSDPAALLEVLQGPVGVCSADLTGKVVINASTVSVEASQQAATLVEQVGGAFLDAPV 121
Query: 506 SGGVMGAXNATLAFMAGGRKEDFER 580
SG + A L F+AGG +R
Sbjct: 122 SGSKIPAQTGKLVFLAGGHHAVIQR 146
>UniRef50_Q1GF31 Cluster: 6-phosphogluconate dehydrogenase
NAD-binding; n=17; Proteobacteria|Rep:
6-phosphogluconate dehydrogenase NAD-binding -
Silicibacter sp. (strain TM1040)
Length = 325
Score = 58.4 bits (135), Expect = 1e-07
Identities = 36/143 (25%), Positives = 62/143 (43%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLGN+GG +A +L++ GF + YD + D + + G P +
Sbjct: 3 IGFIGLGNVGGKLAGSLLRNGFDLTVYDLNPDLVAEYVEKGAQPGTGPLAIMRACDAVIT 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L S V + ++ + ++ ST D K++ + E+G + PVSG
Sbjct: 63 CLPSPAACATVV---EEMLPAVDSSKIWMEMSTTDAAEVKRLAALVSERGGSAMECPVSG 119
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
G A ++ AG + FER
Sbjct: 120 GCHRADTGNISIFAGCDRATFER 142
>UniRef50_Q033P2 Cluster: 3-hydroxyisobutyrate dehydrogenase related
beta-hydroxyacid dehydrogenase; n=1; Lactobacillus casei
ATCC 334|Rep: 3-hydroxyisobutyrate dehydrogenase related
beta-hydroxyacid dehydrogenase - Lactobacillus casei
(strain ATCC 334)
Length = 285
Score = 58.4 bits (135), Expect = 1e-07
Identities = 42/142 (29%), Positives = 67/142 (47%), Gaps = 3/142 (2%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+G+G+MG M +L K G+ V +D + A A + V A S+ +
Sbjct: 3 ITFIGVGDMGSHMVPHLAKAGYDVTVWDKVPAKMAAVAGDHVRTATSLEDAVTASRVIIT 62
Query: 332 ILTSNKVVLDVYLG---KDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
+ S+ V +++G G+V + + GS LI +ST+DP I + K D P
Sbjct: 63 SVMSDDVPA-LHIGTTETPGIVHYLQPGSTLIVTSTLDPRKITAIQAVMPTK-THLLDVP 120
Query: 503 VSGGVMGAXNATLAFMAGGRKE 568
+ GGV A A L +A G K+
Sbjct: 121 MIGGVKYAREAGLVLIAAGDKQ 142
>UniRef50_A6F020 Cluster: Putative uncharacterized protein; n=1;
Marinobacter algicola DG893|Rep: Putative
uncharacterized protein - Marinobacter algicola DG893
Length = 286
Score = 58.4 bits (135), Expect = 1e-07
Identities = 38/136 (27%), Positives = 63/136 (46%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V+ +G+G+MG +A ++ KG V YD S++ + AKNG+ S+
Sbjct: 3 VSIIGVGDMGRDIAVHVRDKGHDVIAYDISEERRSDVAKNGIKVVESLAEAVAKAEVHLV 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
I+ +++ V ++ GS ++ +T P + + +KGLGF DAPV
Sbjct: 63 IVATDEQSETV---TREILESGPAGSTVVILATNSPKTMQVLAAECEDKGLGFVDAPVVF 119
Query: 512 GVMGAXNATLAFMAGG 559
G GA L + GG
Sbjct: 120 GRQGAKEGQLGSLCGG 135
>UniRef50_A5WG80 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=2; Moraxellaceae|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Psychrobacter sp. PRwf-1
Length = 309
Score = 58.4 bits (135), Expect = 1e-07
Identities = 46/137 (33%), Positives = 64/137 (46%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
+V+F+GLG MG MA +LV TV Y+ + D A A T A S+
Sbjct: 17 SVSFIGLGAMGHHMAKHLVGSFDTVMVYNRNFDKATAHAAEFGTQAVSLEQAVSADVIF- 75
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
S L +++VV D+ + + H GS+ +D ++ P K G F DAPVS
Sbjct: 76 SCLPTSQVVDDLI---EQALPHLNDGSVWVDCTSGVPENAKASQAKLNAAGCEFLDAPVS 132
Query: 509 GGVMGAXNATLAFMAGG 559
G GA + TL M GG
Sbjct: 133 GQTSGADSGTLTVMVGG 149
>UniRef50_Q39KK8 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=34; Bacteria|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Burkholderia sp. (strain
383) (Burkholderia cepacia (strain ATCC 17760/ NCIB 9086
/ R18194))
Length = 289
Score = 58.0 bits (134), Expect = 2e-07
Identities = 38/144 (26%), Positives = 68/144 (47%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
++ F+GLG MG +A NL+K G TVR ++ S++ A G ++
Sbjct: 2 DLGFIGLGEMGQAIATNLLKAGHTVRVWNRSRERAEPLAAIGAQIVDT-PADAFRGDAVF 60
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
S+L + ++ D ++A A +G + ++ +T+ + + + +G+ + APV
Sbjct: 61 SMLADDAAARAIF--DDALLAQAPRGLIHVNMATVSVALAESLAHAHASRGIHYVAAPVM 118
Query: 509 GGVMGAXNATLAFMAGGRKEDFER 580
G A A L MAGG E +R
Sbjct: 119 GRPDVAAAARLTIMAGGPAEAIDR 142
>UniRef50_Q392H4 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=8; Bacteria|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Burkholderia sp. (strain
383) (Burkholderia cepacia (strain ATCC 17760/ NCIB 9086
/ R18194))
Length = 292
Score = 58.0 bits (134), Expect = 2e-07
Identities = 40/140 (28%), Positives = 62/140 (44%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
VA LG+G MG +A NL ++GFTVR ++ ++ +A A +GV + +
Sbjct: 12 VAVLGIGVMGAPIARNLARQGFTVRAWNRTRAKADALAADGVAAFATPAETVSDARVVVT 71
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L VL + G++ + ST+ ++ A L F DAPV G
Sbjct: 72 VLNDADGVLK---AMEAAAPKLAAGTIWVQVSTVGVRGIARLAAFARTHDLVFYDAPVQG 128
Query: 512 GVMGAXNATLAFMAGGRKED 571
A NA L +A G + D
Sbjct: 129 SRQPAENAQLVVLAAGPESD 148
>UniRef50_Q2BFK1 Cluster: Oxidoreductase; n=1; Bacillus sp. NRRL
B-14911|Rep: Oxidoreductase - Bacillus sp. NRRL B-14911
Length = 270
Score = 58.0 bits (134), Expect = 2e-07
Identities = 39/132 (29%), Positives = 60/132 (45%), Gaps = 1/132 (0%)
Frame = +2
Query: 188 MAANLVKKGFTVR-GYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXSILTSNKVVLDV 364
MA NL K G+ + ++ + G +S SIL ++K + V
Sbjct: 1 MAKNLQKNGYDLHITAHNNRKPVEELTSMGAVEHSSAADVVSNSEVIISILPADKEMESV 60
Query: 365 YLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAXNATLA 544
L ++ V+ G LI+ ++ P + K++ +KG+ D PVSGG GA N TL
Sbjct: 61 LLSEE-VLNVLNPGQFLIEMTSGSPEMMKKVHAAYQQKGIPVLDGPVSGGTAGAENGTLT 119
Query: 545 FMAGGRKEDFER 580
MAGG + ER
Sbjct: 120 VMAGGDADVLER 131
>UniRef50_A1WJN2 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Proteobacteria|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Verminephrobacter eiseniae
(strain EF01-2)
Length = 297
Score = 58.0 bits (134), Expect = 2e-07
Identities = 41/142 (28%), Positives = 61/142 (42%), Gaps = 1/142 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKK-GFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
+ F+GLG MG + NL +K G V +D L A +GV S
Sbjct: 9 IGFIGLGVMGEPICRNLARKSGAQVLAFDLDAAPLQRLAADGVQGQGSASAVMAQSDTVF 68
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
L S +V + +DG++A A+ G +++D T + +Q+ + F DAPV+
Sbjct: 69 LSLPSGAIVAQLCRQQDGLLASARPGHIVVDLGTSSVDGTRQLAAEFAARQAKFADAPVA 128
Query: 509 GGVMGAXNATLAFMAGGRKEDF 574
A TLA M G E F
Sbjct: 129 RTRAAAQAGTLAVMVGADPELF 150
>UniRef50_A7RG59 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 341
Score = 58.0 bits (134), Expect = 2e-07
Identities = 40/146 (27%), Positives = 68/146 (46%)
Frame = +2
Query: 77 ARTILSTQCLYTAARRAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALN 256
AR + L+ AA +S + + V +G GN+G +A L K +V+ +D ++ N
Sbjct: 4 ARFLARNAFLWRAAFSMSTSASPRTVGLVGTGNVGSAVAVGLRKIDVSVKAFDLQQNNYN 63
Query: 257 AAAKNGVTPANSIXXXXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTID 436
G T NS + L + V L G+++ K+GS+ ID +T D
Sbjct: 64 FLESTGTTLVNSPEEVTKDVDVLITALPKPQHVKSA-LEDTGMLSMLKEGSVWIDHTTTD 122
Query: 437 PNVPKQIFPIALEKGLGFTDAPVSGG 514
N ++ +A KG+ +AP++GG
Sbjct: 123 YNETIRLGELATSKGVHAVEAPLTGG 148
>UniRef50_Q2CHC8 Cluster: Oxidoreductase; n=1; Oceanicola granulosus
HTCC2516|Rep: Oxidoreductase - Oceanicola granulosus
HTCC2516
Length = 288
Score = 57.6 bits (133), Expect = 2e-07
Identities = 40/144 (27%), Positives = 61/144 (42%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V +GLG MG M L ++GF R ++ + + G +S
Sbjct: 3 VGVIGLGIMGAPMVRRLRERGFETRVWNLEPERFAQVSDAGALWCDSPAGVRAASDIVVL 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+ + V DV G G+ A A +++D ST+ P + I A + DAPVSG
Sbjct: 63 CVLDGRAVEDVCFGAQGL-AGAGGAEIVVDCSTVPPEATRDI---AGRMDAAWIDAPVSG 118
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
G A L + GG++ D ER+
Sbjct: 119 GPQLAETGELTMLLGGQERDIERA 142
>UniRef50_Q5LQR0 Cluster: 6-phosphogluconate dehydrogenase domain
protein; n=14; Proteobacteria|Rep: 6-phosphogluconate
dehydrogenase domain protein - Silicibacter pomeroyi
Length = 302
Score = 57.2 bits (132), Expect = 3e-07
Identities = 48/153 (31%), Positives = 69/153 (45%), Gaps = 4/153 (2%)
Frame = +2
Query: 134 SNTDK-NVAFLGLGNMGGFMAANLVKKGF--TVRGYDPSKDALNAAAKNGVTPANSIXXX 304
+N DK ++ F+GLG MG M L K G TV G + + + AA G T A
Sbjct: 4 NNMDKAHIGFIGLGLMGAAMVECLQKAGHAVTVLG-NRDRTGVEAALARGATEAAHARAV 62
Query: 305 XXXXXXXXSIL-TSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG 481
+ TS +V +Y G DGV+A ++G ++ID T P ++I KG
Sbjct: 63 AEASDIVMLCMGTSAQVESRIY-GDDGVLAGTREGQVVIDFGTSLPASTRRIGGDLAGKG 121
Query: 482 LGFTDAPVSGGVMGAXNATLAFMAGGRKEDFER 580
+ DAP+ A + L M G K F+R
Sbjct: 122 ATYLDAPLGRTPAHARDGLLNIMCSGDKATFDR 154
>UniRef50_Q5FQ06 Cluster: Putative oxidoreductase; n=1;
Gluconobacter oxydans|Rep: Putative oxidoreductase -
Gluconobacter oxydans (Gluconobacter suboxydans)
Length = 290
Score = 57.2 bits (132), Expect = 3e-07
Identities = 38/144 (26%), Positives = 61/144 (42%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+G G M M ANL K G+ V Y PS K+ S
Sbjct: 6 IGFIGYGAMAQRMGANLRKAGYPVVAYAPS------GGKDETEMLPSPRAIAEAAEIIIF 59
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+ ++ + G++G +A G L++D+ST+ P+ +A+E G DAP+SG
Sbjct: 60 CVPNDAAENESLHGENGALAALTPGKLVLDTSTVSPDQADAFASLAVEHGFSLLDAPMSG 119
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
A L + GG + +R+
Sbjct: 120 STPEAETGDLVMLVGGDEAVVKRA 143
>UniRef50_A0RU56 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Cenarchaeum symbiosum|Rep: 3-hydroxyisobutyrate
dehydrogenase - Cenarchaeum symbiosum
Length = 282
Score = 57.2 bits (132), Expect = 3e-07
Identities = 38/134 (28%), Positives = 54/134 (40%)
Frame = +2
Query: 176 MGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXSILTSNKVV 355
+G + L+K G V Y+ + D A G A S + +T +
Sbjct: 2 LGTGIGLRLLKTGINVIAYNRTADKTKALEDAGARIAKSPGEAAGLSDTVITCVTDADAL 61
Query: 356 LDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAXNA 535
V G++G+ A K +L D STI+P I + G+ DAPV GG A
Sbjct: 62 EQVSFGENGIAQGAHKDLVLCDMSTINPEGAVSISKKLADAGIRMVDAPVMGGPGAAMRG 121
Query: 536 TLAFMAGGRKEDFE 577
L MA G K +E
Sbjct: 122 ELVIMASGDKGAYE 135
>UniRef50_A5P600 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Methylobacterium sp. 4-46|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Methylobacterium sp. 4-46
Length = 290
Score = 56.8 bits (131), Expect = 4e-07
Identities = 40/144 (27%), Positives = 64/144 (44%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ ++GLG +G MA +LV G V +D +D AA G A+ +
Sbjct: 3 IGWIGLGKLGAPMARHLVAAGHAVLAFD--RDPGRLAAVPGAEAAD--LPGVAACGVVVT 58
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L + + V LG +G++A +L+++ST+ P + A G+ + APVSG
Sbjct: 59 SLPDDAALAAVALGPEGLLARMAPDGVLVETSTVSPETSAALREAAEAGGILYLAAPVSG 118
Query: 512 GVMGAXNATLAFMAGGRKEDFERS 583
A ATL G + ER+
Sbjct: 119 STATAEAATLTLFCSGPETALERA 142
>UniRef50_Q8PK98 Cluster: 3-hydroxyisobutirate dehydrogenase; n=3;
Proteobacteria|Rep: 3-hydroxyisobutirate dehydrogenase -
Xanthomonas axonopodis pv. citri
Length = 300
Score = 56.0 bits (129), Expect = 7e-07
Identities = 38/147 (25%), Positives = 58/147 (39%), Gaps = 2/147 (1%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
++ +G+GN+G A + +G V +D AL A + G T A +
Sbjct: 2 DIGLVGMGNIGRHFVARWLAQGHRVIVHDTRAQALQQAKEAGATTAAGMADVLANAEVIA 61
Query: 329 SILTSNKVVLDVY--LGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
L VVL+V L + L++D ST ++ + + F AP
Sbjct: 62 LSLPLPSVVLEVARTLAAAAAATEMRDSLLVVDLSTTGAQTTSEVGHLLERADVSFLSAP 121
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFERS 583
VSGG A L MA G +ER+
Sbjct: 122 VSGGTAAAAQGVLTVMAAGPLAAYERA 148
>UniRef50_Q2JEN4 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Frankia sp. CcI3|Rep:
6-phosphogluconate dehydrogenase, NAD-binding - Frankia
sp. (strain CcI3)
Length = 290
Score = 56.0 bits (129), Expect = 7e-07
Identities = 40/136 (29%), Positives = 59/136 (43%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+GLG MG MA NL+ G TV ++ S D + A G PA+ S
Sbjct: 3 IGFIGLGGMGSAMARNLIDAGHTVLAWNRSPDPVTELAAAGAVPAS--ISEAFATGIVLS 60
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L ++ V D L V+ A G+L ++ +T+ + Q E GL + APV G
Sbjct: 61 MLADDQAVTDRLL-DPRVLTAAPAGALHVNMATVSTALAIQARREHAEHGLRYLAAPVFG 119
Query: 512 GVMGAXNATLAFMAGG 559
A L + G
Sbjct: 120 RTDAARAGNLTIVTSG 135
>UniRef50_Q120Q9 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=7; Burkholderiales|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 297
Score = 56.0 bits (129), Expect = 7e-07
Identities = 39/145 (26%), Positives = 62/145 (42%), Gaps = 1/145 (0%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYD-PSKDALNAAAKNGVTPANSIXXXXXXXXX 322
K + +G+G MG +A+N++K G+ + + P L G T +S
Sbjct: 2 KKIGMVGIGMMGHGIASNIIKHGYPMVLLEHPGNQPLQGLIAAGATTTDSAATLAGVVDI 61
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
+T V DV K G++ K G+++ID ST P+ +I + G F DAP
Sbjct: 62 IILCVTGTPEVEDVLYRKGGLLEGIKPGTIVIDCSTAIPSSTIRIAESVEKAGGRFLDAP 121
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFE 577
++ A L + GG FE
Sbjct: 122 MTRTPKEAAEGRLNLIVGGDPALFE 146
>UniRef50_Q6C351 Cluster: Yarrowia lipolytica chromosome F of strain
CLIB122 of Yarrowia lipolytica; n=1; Yarrowia
lipolytica|Rep: Yarrowia lipolytica chromosome F of
strain CLIB122 of Yarrowia lipolytica - Yarrowia
lipolytica (Candida lipolytica)
Length = 334
Score = 56.0 bits (129), Expect = 7e-07
Identities = 51/165 (30%), Positives = 69/165 (41%), Gaps = 14/165 (8%)
Frame = +2
Query: 116 ARRAYSSNTDKNVAFLGLGNMGGFMAANLVKK------GFTVRGYDPSKDALNAAAKNG- 274
A R ++ D + F+GLG MG MA NL KK V +D +K AL AK+
Sbjct: 12 ALRPLRASRDLSYGFIGLGRMGLPMALNLQKKLPGVDADSKVNVFDMNKAALEQIAKDKD 71
Query: 275 -----VTPANSIXXXXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDP 439
+ S ++L V VY + K + +D STID
Sbjct: 72 PKGAQLEVLGSAVDVASKSDVIFTMLPEPVHVRGVYTDLVNNLGD-KTSKIFVDCSTIDT 130
Query: 440 NVPKQIFPIALEK--GLGFTDAPVSGGVMGAXNATLAFMAGGRKE 568
+ + +K F DAPVSGGV+GA TL FM G K+
Sbjct: 131 QTSIECGKLVTDKDASAAFVDAPVSGGVVGAEKGTLTFMVGCNKD 175
>UniRef50_A0AWL7 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=1; Arthrobacter sp. FB24|Rep:
6-phosphogluconate dehydrogenase, NAD-binding precursor
- Arthrobacter sp. (strain FB24)
Length = 297
Score = 55.6 bits (128), Expect = 1e-06
Identities = 37/124 (29%), Positives = 60/124 (48%), Gaps = 3/124 (2%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
+V +GLG MG +AA+L+ +V +D D + A G P+ S
Sbjct: 5 HVGVVGLGGMGKALAASLIAADHSVAVWDRHTDRVATTAMIGAAPSVSPRQLAEQSHVIF 64
Query: 329 SILTSNKVVLDVYLGKD-GVVAHAKKGSLLIDSSTIDPNVPKQIFP--IALEKGLGFTDA 499
L + V +V ++ GV+A + G+L++D +T DP + + + AL G + DA
Sbjct: 65 LALPNPTAVREVLYDEEAGVLAGLRAGALIVDMTTGDPELAQDVAQRVAALGNGARYVDA 124
Query: 500 PVSG 511
PVSG
Sbjct: 125 PVSG 128
>UniRef50_Q98K09 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=7;
Alphaproteobacteria|Rep: 3-hydroxyisobutyrate
dehydrogenase - Rhizobium loti (Mesorhizobium loti)
Length = 312
Score = 55.2 bits (127), Expect = 1e-06
Identities = 42/147 (28%), Positives = 64/147 (43%), Gaps = 2/147 (1%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGF--TVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXX 319
+ + F+GLG MG +A N+V KG+ T G K A + + G A++
Sbjct: 8 EKIGFIGLGLMGHGIAKNIVDKGYPLTFLGRKNRKPAEDLLGR-GAREASTSRDVAVASD 66
Query: 320 XXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 499
+T ++ V + G G+ KKGS+++D ST DP + G+ + DA
Sbjct: 67 IVFICVTGSREVEAIIRGPGGLKEGLKKGSVVVDCSTSDPVSTVALAAELKALGIDYVDA 126
Query: 500 PVSGGVMGAXNATLAFMAGGRKEDFER 580
P+S A TL M G F R
Sbjct: 127 PLSRTPKEAWEGTLDAMVGAPDAVFAR 153
>UniRef50_Q6F842 Cluster: Putative 3-hydroxyisobutyrate
dehydrogenase or 2-hydroxy-3- oxopropionate reductase;
n=2; Acinetobacter|Rep: Putative 3-hydroxyisobutyrate
dehydrogenase or 2-hydroxy-3- oxopropionate reductase -
Acinetobacter sp. (strain ADP1)
Length = 291
Score = 55.2 bits (127), Expect = 1e-06
Identities = 38/142 (26%), Positives = 65/142 (45%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AF+G+G MG MA LV+ GF+V ++ ++ A + G +
Sbjct: 9 IAFIGMGLMGSRMATRLVQAGFSVAVWNRTQSACDVLLDMGAQALS--LEKIADYPVILM 66
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L ++ V VY + V + +++D S++ N K + A ++ + D+PVSG
Sbjct: 67 CLADDQAVNHVY---EQVHHLVRPQQIIVDFSSLSVNQTKYLADRAQQQQAIWIDSPVSG 123
Query: 512 GVMGAXNATLAFMAGGRKEDFE 577
G GA TL AGG + +
Sbjct: 124 GTSGAEQGTLVIFAGGNESTIQ 145
>UniRef50_Q82ZC2 Cluster: 6-phosphogluconate dehydrogenase family
protein; n=16; Bacteria|Rep: 6-phosphogluconate
dehydrogenase family protein - Enterococcus faecalis
(Streptococcus faecalis)
Length = 299
Score = 54.8 bits (126), Expect = 2e-06
Identities = 37/140 (26%), Positives = 62/140 (44%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
++ F+GLG MG MA N+ ++G+ + G+D +K+A A + G++ +S+
Sbjct: 2 DIGFIGLGKMGLNMALNVHEQGWPIIGFDVTKEARATAREQGLSVVDSLSELLKALNKRK 61
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
I S +V +++DS + + +A EKG+ F D S
Sbjct: 62 VIFLSTPAGQITNQLVAELVEQLAPEDIIVDSGNSNFHDSVANAQLAKEKGIYFIDCGTS 121
Query: 509 GGVMGAXNATLAFMAGGRKE 568
GG+ GA M GG E
Sbjct: 122 GGIKGAREGA-CLMVGGAPE 140
>UniRef50_Q46TQ0 Cluster: UDP-glucose/GDP-mannose
dehydrogenase:Prephenate dehydrogenase:NADP
oxidoreductase, coenzyme
F420-dependent:6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Ralstonia eutropha JMP134|Rep:
UDP-glucose/GDP-mannose dehydrogenase:Prephenate
dehydrogenase:NADP oxidoreductase, coenzyme
F420-dependent:6-phosphogluconate dehydrogenase,
NAD-binding - Ralstonia eutropha (strain JMP134)
(Alcaligenes eutrophus)
Length = 294
Score = 54.8 bits (126), Expect = 2e-06
Identities = 37/143 (25%), Positives = 61/143 (42%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ F+G G MG MA ++ G V YD + + +AA G+ A S+ S
Sbjct: 3 IGFIGTGKMGLPMARHIAAAGHDVVAYDIAPEQASAARHAGLAVAPSLADAVSAAEVIFS 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+ N G+ + A+ G+L ID+ST+ P + P+ + + + VSG
Sbjct: 63 SMP-NDGAFSAVAGQ--IAKAARPGALYIDTSTVSPAASAAVAPLLAARDIAYLRVTVSG 119
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
A A L + G + +ER
Sbjct: 120 NNHMAEAAKLTALVSGPADAYER 142
>UniRef50_O66454 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3;
cellular organisms|Rep: 3-hydroxyisobutyrate
dehydrogenase - Aquifex aeolicus
Length = 288
Score = 54.8 bits (126), Expect = 2e-06
Identities = 38/145 (26%), Positives = 67/145 (46%), Gaps = 1/145 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKN-GVTPANSIXXXXXXXXXXX 328
V F+GLG++G +A L+++G + ++ + + AK G +S
Sbjct: 3 VGFIGLGHLGRAIAKRLIEQGVELIVWNRTLSKAHEFAKETGAEVTSSPADLINKVDRVF 62
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
I+ ++ +V G+ G+V KG +ID +T ++ + + G + DAPV
Sbjct: 63 VIVFDSQASEEVIFGEKGLVKGDIKGKTVIDMTTNHYLYAQKAYEELKKLGAFYLDAPVL 122
Query: 509 GGVMGAXNATLAFMAGGRKEDFERS 583
G V+ A L + GG KE FE +
Sbjct: 123 GSVIPALKGELTIVVGGDKEKFEEN 147
>UniRef50_Q0UVR9 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 288
Score = 54.8 bits (126), Expect = 2e-06
Identities = 36/84 (42%), Positives = 48/84 (57%), Gaps = 3/84 (3%)
Frame = +2
Query: 329 SILTSNKVVLDVYLG-KDGVVAHAK-KGSLLIDSSTIDPNVPKQIFPIALEKGLG-FTDA 499
SI+ K V VYL K GV+A K +G L+++ STID K++ E+GLG + DA
Sbjct: 27 SIVPGGKDVKTVYLDEKTGVIAARKDEGRLMLECSTIDVESTKEVGRKLKEEGLGTYIDA 86
Query: 500 PVSGGVMGAXNATLAFMAGGRKED 571
PVSGGV A TL+ + G D
Sbjct: 87 PVSGGVPAAEAGTLSMLIGAPPPD 110
>UniRef50_Q3WJ00 Cluster: 6-phosphogluconate dehydrogenase, NAD
binding domain; n=1; Frankia sp. EAN1pec|Rep:
6-phosphogluconate dehydrogenase, NAD binding domain -
Frankia sp. EAN1pec
Length = 438
Score = 54.4 bits (125), Expect = 2e-06
Identities = 41/145 (28%), Positives = 58/145 (40%)
Frame = +2
Query: 125 AYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXX 304
+Y F+GLG+MG MA L +G + Y +L A T A +
Sbjct: 163 SYHDEDTVKTGFIGLGSMGLPMAQRLQSQGHDLTLYARRPASLEPFAGTSATIAATPAEM 222
Query: 305 XXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGL 484
+ V +V G DG+ G++++ ST+ P ++I A GL
Sbjct: 223 GASVDAVGICVFDAAGVEEVMFGPDGLAGTLNPGAVVLVHSTVAPAQIRRIAGRAATHGL 282
Query: 485 GFTDAPVSGGVMGAXNATLAFMAGG 559
DAPVSGG A L M GG
Sbjct: 283 RVLDAPVSGGQPRALAGELTIMIGG 307
>UniRef50_A3WMG5 Cluster: Probable 3-hydroxyisobutyrate
dehydrogenase; n=1; Idiomarina baltica OS145|Rep:
Probable 3-hydroxyisobutyrate dehydrogenase - Idiomarina
baltica OS145
Length = 284
Score = 54.0 bits (124), Expect = 3e-06
Identities = 35/137 (25%), Positives = 65/137 (47%), Gaps = 1/137 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AFLGLG MG MA +L+ G ++ ++ ++ + G A++ +
Sbjct: 4 IAFLGLGAMGIRMAQHLIDAGHSLTVWNRTESRAEPLLEQGAQWADTPAEAAQGAELVIA 63
Query: 332 ILTSNKVVLDVYLGKD-GVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
++ + V+L + G ++ I+SST+ + K++ A ++G +APVS
Sbjct: 64 MVRDDDASAAVWLDEQTGAFKGMSDNAIAIESSTLSVDWVKELAQQAQQRGKQLIEAPVS 123
Query: 509 GGVMGAXNATLAFMAGG 559
G A NA L ++ GG
Sbjct: 124 GSRPQAQNAELVYLVGG 140
>UniRef50_Q7Q161 Cluster: ENSANGP00000013149; n=11; Culicidae|Rep:
ENSANGP00000013149 - Anopheles gambiae str. PEST
Length = 581
Score = 54.0 bits (124), Expect = 3e-06
Identities = 36/140 (25%), Positives = 60/140 (42%)
Frame = +2
Query: 158 FLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXSIL 337
FLGLG MG + NL+K G +V ++ S + G A++ S +
Sbjct: 300 FLGLGVMGCGIVKNLIKSGHSVVVWNRSAHKCRKFQEVGAEVADTPSDVVEMTDVTYSCV 359
Query: 338 TSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGV 517
+ +V D+ G GV++ G ++ + +DP I + KG + +A + G
Sbjct: 360 SDPQVAKDMVFGNCGVMSANLAGKGYVEMTGVDPETSNDINEAIISKGGRYLEAQIQGSK 419
Query: 518 MGAXNATLAFMAGGRKEDFE 577
A TL +A G + FE
Sbjct: 420 NQAEEGTLIILASGDRLLFE 439
>UniRef50_A6RMW8 Cluster: Putative uncharacterized protein; n=2;
Sclerotiniaceae|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 446
Score = 54.0 bits (124), Expect = 3e-06
Identities = 47/156 (30%), Positives = 75/156 (48%), Gaps = 8/156 (5%)
Frame = +2
Query: 134 SNTDKN-VAFLGLGNMGGFMAANLVKKGFTVRG---YDPSKDALNAAAKNGVTPANSIXX 301
S++DK VAF+GLG MG MA NL+K F+V G Y+P+ + +A N T S
Sbjct: 2 SSSDKPAVAFIGLGAMGMGMATNLLKT-FSVTGFDVYEPTLEKFRSAGGNTATTPRS--A 58
Query: 302 XXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDP-NVP--KQIFPIAL 472
+ T+ + + ++ G + + + +I SST P +VP +++
Sbjct: 59 VANAQYIVIMVATAAQTLAVLFDDVTGAIHELQPNATIILSSTAFPEHVPEVRELLDNKY 118
Query: 473 -EKGLGFTDAPVSGGVMGAXNATLAFMAGGRKEDFE 577
K + DAPVSGG A TL +A G ++ +
Sbjct: 119 NRKDVELVDAPVSGGTSRAALGTLVILASGPEKSLD 154
>UniRef50_Q6RXW5 Cluster: Succinic semialdehyde dehydrogenase; n=2;
Rhodococcus|Rep: Succinic semialdehyde dehydrogenase -
Rhodococcus sp. TK6
Length = 262
Score = 53.6 bits (123), Expect = 4e-06
Identities = 40/144 (27%), Positives = 69/144 (47%), Gaps = 1/144 (0%)
Frame = +2
Query: 161 LGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXSILT 340
+GLG +GG + A+L + G V GYD +++ L ++ +PA S S+
Sbjct: 5 IGLGPIGGKIGAHLAELGRKVYGYDFNQERLREWSEETASPAGS-DLAAVDWPSIDSVHV 63
Query: 341 SNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVM 520
+ ++ V + + AH + + +T+ P ++I P A G +APVSGG
Sbjct: 64 AVRLADQVSSVFEALAAHTAQPLTVFVHTTLAPADARKILPSA-PAGWRVFEAPVSGGPQ 122
Query: 521 GAXNATL-AFMAGGRKEDFERSFL 589
GA + ++ F+AG D E + L
Sbjct: 123 GARHGSMTVFLAGPAPTDAENALL 146
>UniRef50_Q21ZN3 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Rhodoferax ferrireducens T118|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Rhodoferax ferrireducens (strain DSM 15236 / ATCC
BAA-621 / T118)
Length = 292
Score = 53.6 bits (123), Expect = 4e-06
Identities = 40/150 (26%), Positives = 63/150 (42%), Gaps = 2/150 (1%)
Frame = +2
Query: 134 SNTDKNVAFLGLGNMGGFMAANLVKKGF--TVRGYDPSKDALNAAAKNGVTPANSIXXXX 307
SNT + +GLG MG + NL+K GF TV G + ++ +++ G + S+
Sbjct: 3 SNTSLRIGLIGLGLMGHGIGRNLLKNGFALTVMG-NVNRAPVDSLVSLGANESKSVAELV 61
Query: 308 XXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLG 487
+T + V + G++ + G ++ID ST P+ I LE G
Sbjct: 62 DASDVVMLCVTGSPQVESLMNRDQGILQSIRPGQIVIDCSTSQPSSSAIINAALLEAGAL 121
Query: 488 FTDAPVSGGVMGAXNATLAFMAGGRKEDFE 577
F DAP+ A L M G + E
Sbjct: 122 FVDAPLGRTPAEAEAGKLNVMVGATPQLLE 151
>UniRef50_Q12H32 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=1; Polaromonas sp. JS666|Rep:
6-phosphogluconate dehydrogenase, NAD-binding precursor
- Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 297
Score = 53.6 bits (123), Expect = 4e-06
Identities = 42/151 (27%), Positives = 69/151 (45%), Gaps = 6/151 (3%)
Frame = +2
Query: 146 KNVAFLGL-GNMGGFMAANLVKKGFTV-----RGYDPSKDALNAAAKNGVTPANSIXXXX 307
K++ +G G MG +A NL KGF + R + D L A AK +PA
Sbjct: 2 KHIGMIGASGLMGHGIARNLQAKGFDLSLTVHRNTERVADLLAAGAKQVASPAG-----L 56
Query: 308 XXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLG 487
+T + V G DGV++ A G ++ID+ST +P +++ + E+G+
Sbjct: 57 GDCDAVIICVTGSPQVEQTLSGPDGVLSRALAGLIVIDTSTSEPESTRRLAALCAERGVT 116
Query: 488 FTDAPVSGGVMGAXNATLAFMAGGRKEDFER 580
DAP++ + A L M G + F++
Sbjct: 117 LVDAPLARTPVEAELGRLNTMVGAEQAVFDK 147
>UniRef50_A3EW86 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Leptospirillum sp. Group II UBA|Rep:
3-hydroxyisobutyrate dehydrogenase - Leptospirillum sp.
Group II UBA
Length = 279
Score = 53.6 bits (123), Expect = 4e-06
Identities = 41/138 (29%), Positives = 64/138 (46%), Gaps = 2/138 (1%)
Frame = +2
Query: 176 MGGFMAANLVKKGFTVRGYDPSKDAL--NAAAKNGVTPANSIXXXXXXXXXXXSILTSNK 349
MG M L+ G V GY+ + L + TPA+ I + ++++
Sbjct: 1 MGVRMVRRLLDNGIPVTGYNRTAGRLPSHPLFHAAHTPAD-IAEKSDLIFLMVTDGSASR 59
Query: 350 VVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVMGAX 529
+L+ G DG+ + GSL+I+ STI P ++ L KG G+ D PVSG ++ A
Sbjct: 60 ALLE---GPDGIARGLRPGSLVINMSTIAPEEAQEEALSLLAKGAGYLDVPVSGSLVPAE 116
Query: 530 NATLAFMAGGRKEDFERS 583
L +AGG ER+
Sbjct: 117 KGELLLLAGGDGAALERA 134
>UniRef50_Q4PCH4 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 366
Score = 53.6 bits (123), Expect = 4e-06
Identities = 56/187 (29%), Positives = 82/187 (43%), Gaps = 32/187 (17%)
Frame = +2
Query: 92 STQC-LYTAARRAYSSNTDKNVAFLGLGNMGGFMAANLVKK--------GFTVRGYDPSK 244
+T+C L+ RR + K + F+GLG MG MA NL+ K T +D +
Sbjct: 4 TTRCMLHHTIRRCVPHDRSKTIGFIGLGAMGKEMANNLLSKTLASNPDPAVTFVVHDAFE 63
Query: 245 DALNA--AAKNGVTP------ANSIXXXXXXXXXXXSILTSNKVVLDVYLGKDGV----- 385
++ A + P A+S ++L S+ V VY ++G+
Sbjct: 64 QSITRFLTANTSLYPNRNILAASSPAGIAKLSGTIVTMLPSSPQVESVYTHENGILDGLE 123
Query: 386 ------VAHAKKGSLLIDSSTIDPNVPKQ----IFPIALEKGLGFTDAPVSGGVMGAXNA 535
V A+ +L ID +T+DP+V Q I DAPVSGGV+GA A
Sbjct: 124 SFQAAAVDDAQAKTLCIDCTTLDPDVAVQTATAIKNANANGAFDMIDAPVSGGVVGANAA 183
Query: 536 TLAFMAG 556
TL+FM G
Sbjct: 184 TLSFMVG 190
>UniRef50_Q9JYH6 Cluster: 3-hydroxyacid dehydrogenase; n=5;
Proteobacteria|Rep: 3-hydroxyacid dehydrogenase -
Neisseria meningitidis serogroup B
Length = 289
Score = 53.2 bits (122), Expect = 5e-06
Identities = 39/144 (27%), Positives = 61/144 (42%), Gaps = 1/144 (0%)
Frame = +2
Query: 131 SSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXX 310
S+N + ++GLG MG M L+ G V Y+ S D + G +
Sbjct: 2 SANEYAQIGWIGLGQMGLPMVTRLLDGGIEVGVYNRSPDKTAPISAKGAKVYGNTAELVR 61
Query: 311 XXXXXXSILTSNKVVLDVYLG-KDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLG 487
+++ V D+ G +DG+ G ++++ STI P + + G
Sbjct: 62 DYPVIFLMVSDYAAVCDILNGVRDGLA-----GKIIVNMSTISPTENLAVKALVEAAGGQ 116
Query: 488 FTDAPVSGGVMGAXNATLAFMAGG 559
F +APVSG V A N TL + GG
Sbjct: 117 FAEAPVSGSVGPATNGTLLILFGG 140
>UniRef50_Q9RX16 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=6;
Bacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Deinococcus radiodurans
Length = 310
Score = 52.8 bits (121), Expect = 7e-06
Identities = 39/141 (27%), Positives = 61/141 (43%)
Frame = +2
Query: 155 AFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXSI 334
AFLGLG MG MAA+L + + G + A A++ A S +
Sbjct: 21 AFLGLGAMGFPMAAHLAAQAASGGGRALVWNRTEAKAQDHAARAGSEAVSLADTAQADVL 80
Query: 335 LTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGG 514
T +V + H + G++ +D ++ P+ ++ G+ F DAPVSGG
Sbjct: 81 FTCLPTSAEVDEIIAALSPHLRPGTVWVDCTSGHPDAARRQRETLDALGVKFLDAPVSGG 140
Query: 515 VMGAXNATLAFMAGGRKEDFE 577
GA TL M GG ++ +
Sbjct: 141 TSGAEAGTLTVMLGGPADEID 161
>UniRef50_Q2UHA9 Cluster: Predicted dehydrogenase; n=16;
Pezizomycotina|Rep: Predicted dehydrogenase -
Aspergillus oryzae
Length = 363
Score = 52.8 bits (121), Expect = 7e-06
Identities = 54/177 (30%), Positives = 81/177 (45%), Gaps = 23/177 (12%)
Frame = +2
Query: 116 ARRAYSSNT--DKNVAFLGLGNMGGFMAANL--------------VKKGFTVRGYDPSKD 247
A RA+SS+ D F+GLG MG MA NL + + R + +++
Sbjct: 30 ATRAFSSSLRRDDTWGFIGLGQMGYAMAKNLRAKIPASDTLIIRDINENTAKRFVEETQE 89
Query: 248 AL-NAAAKNGVTPANSIXXXXXXXXXXXSILTS---NKVVLDVY--LGKDGVVAHAKKGS 409
A+ N+ AK + I+TS + V +V+ + + G + +K
Sbjct: 90 AVRNSGAKEDTSKVLIAQNAREVAEQSTVIVTSLPEPEHVKNVFYCMLRHGELPALEKER 149
Query: 410 LLIDSSTIDPNVPKQIFPIALEKGLG-FTDAPVSGGVMGAXNATLAFMAGGRKEDFE 577
L ID+STIDP ++I G F DAP+SGGV+GA TL+FM G + E
Sbjct: 150 LFIDTSTIDPASSREIANAIHTTRQGRFVDAPMSGGVVGARAGTLSFMFGASSQTGE 206
>UniRef50_A1UDJ6 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=7; Mycobacterium|Rep:
6-phosphogluconate dehydrogenase, NAD-binding precursor
- Mycobacterium sp. (strain KMS)
Length = 292
Score = 52.4 bits (120), Expect = 9e-06
Identities = 38/122 (31%), Positives = 52/122 (42%), Gaps = 1/122 (0%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
+ V +GLG MG +AA+L+ V +D D L + G A
Sbjct: 2 RRVGVIGLGGMGSALAASLLATDHYVVCFDIRPDVLRPIVELGAEAAADARELAGACDVV 61
Query: 326 XSILTSNKVVLDVYLGKD-GVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
+ L VL+V LG + GV+A G+ L+D ST +P V I G F D P
Sbjct: 62 LTFLPGPSQVLEVALGSERGVLAGLADGAALLDMSTCNPEVAAIIGQAYDAAGRRFVDCP 121
Query: 503 VS 508
VS
Sbjct: 122 VS 123
>UniRef50_A0R1N5 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Mycobacterium|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Mycobacterium smegmatis
(strain ATCC 700084 / mc(2)155)
Length = 263
Score = 52.4 bits (120), Expect = 9e-06
Identities = 37/143 (25%), Positives = 59/143 (41%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ FLG G MG M L G V + + A A +G TP +
Sbjct: 3 IGFLGAGRMGAPMVQRLTAAGHDVHALGRTDEKRTAVAGSGATPVAAATDAVHGADVVIV 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+ +++ V L D ++ G++L+ +T P + I A ++G+ DAPVSG
Sbjct: 63 CVFTDEQVRT--LCTDTLLDAMAPGAVLVLHTTGSPRTAEDIAARAADRGVAVVDAPVSG 120
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
G ++ AGG + ER
Sbjct: 121 GPHDIAAGSVTVFAGGDADVVER 143
>UniRef50_Q9I1R8 Cluster: Probable dehydrogenase; n=7; Pseudomonas
aeruginosa|Rep: Probable dehydrogenase - Pseudomonas
aeruginosa
Length = 291
Score = 52.0 bits (119), Expect = 1e-05
Identities = 40/143 (27%), Positives = 60/143 (41%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V FLGLG MG MA LV+ G V ++ S A G A + S
Sbjct: 3 VGFLGLGGMGAAMATRLVQAGLEVTVWNRSAAACEPLVALGAARAEEVGELFGLDVVI-S 61
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L ++ + V L G + A+ G + + ST+ + + + +GL F APV G
Sbjct: 62 MLADDQAIRGVLLDS-GALERARPGLIHLSMSTLSLDCVEALDQAHQRQGLAFVAAPVFG 120
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
A L + GG +E E+
Sbjct: 121 RTDVAEAGKLNIVVGGPEEAIEQ 143
>UniRef50_A5FVG0 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=1; Acidiphilium cryptum
JF-5|Rep: 6-phosphogluconate dehydrogenase, NAD-binding
precursor - Acidiphilium cryptum (strain JF-5)
Length = 292
Score = 52.0 bits (119), Expect = 1e-05
Identities = 38/136 (27%), Positives = 59/136 (43%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ +GLG MG MAA L+++G V G+ ++ A A A G+ S
Sbjct: 5 IGVIGLGRMGAAMAARLIERGHQVCGW--NRTAARAEAIQGLAAKASPAEVAMSADYVIV 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L Y G+ G+++ + +L+ID ST+ P + G F PV G
Sbjct: 63 MLLDETASRAAYHGEGGLLSANLQQALVIDMSTLKPADMQANAEAVTAHGGRFVACPVGG 122
Query: 512 GVMGAXNATLAFMAGG 559
V A + L +AGG
Sbjct: 123 TVGPARSGKLLGLAGG 138
>UniRef50_Q89GM2 Cluster: Bll6323 protein; n=6; Proteobacteria|Rep:
Bll6323 protein - Bradyrhizobium japonicum
Length = 300
Score = 51.6 bits (118), Expect = 2e-05
Identities = 36/150 (24%), Positives = 64/150 (42%), Gaps = 2/150 (1%)
Frame = +2
Query: 140 TDKNVAFLGLGNMGGFMAANLVKKG-FTVRGYD-PSKDALNAAAKNGVTPANSIXXXXXX 313
T V +G+G MG +A N++ +G F + D P ++ G T +
Sbjct: 5 TVTRVGIIGVGLMGHGIAKNVLARGRFPLAFLDHPGNQPVDDLVGLGATACKTPADVAEA 64
Query: 314 XXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 493
+T + V V G G ++ +KG++++D ST P ++ G F
Sbjct: 65 SDIIILCVTGSPQVEAVLTGDAGALSRLRKGTIIVDCSTALPESTLRMAAAVRAAGGAFL 124
Query: 494 DAPVSGGVMGAXNATLAFMAGGRKEDFERS 583
DAP++ A + L + GG + DF+ +
Sbjct: 125 DAPMTRTAKHAEDGALNLLVGGDETDFQNA 154
>UniRef50_A1SQ87 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=4; Bacteria|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Nocardioides sp. (strain
BAA-499 / JS614)
Length = 318
Score = 51.6 bits (118), Expect = 2e-05
Identities = 36/144 (25%), Positives = 67/144 (46%), Gaps = 1/144 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V ++G G MG MA+ L + G V ++ ++ A ++ G A++I
Sbjct: 13 VGWIGAGRMGAAMASRLARAGEDVTVWNRTRAKAEALSEVGCGVADTIADLRGHDVVFTM 72
Query: 332 ILTSNKVVLDVYLGKDGVVAH-AKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
+ T + V +G+ G++A A+ ++++D ST+ + E+G+ F APVS
Sbjct: 73 VSTPADLE-QVLVGEGGLLADPARVPAVVVDCSTVSTESSAAMRAACSERGVAFLAAPVS 131
Query: 509 GGVMGAXNATLAFMAGGRKEDFER 580
G L+ + G +E +ER
Sbjct: 132 GNGKVVRAGGLSLVVSGPEETYER 155
>UniRef50_Q92P61 Cluster: 6-phosphogluconate dehydrogenase,
decarboxylating; n=25; Alphaproteobacteria|Rep:
6-phosphogluconate dehydrogenase, decarboxylating -
Rhizobium meliloti (Sinorhizobium meliloti)
Length = 476
Score = 51.2 bits (117), Expect = 2e-05
Identities = 38/149 (25%), Positives = 63/149 (42%), Gaps = 6/149 (4%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALN------AAAKNGVTPANSIXXXXXX 313
+ +GLG MG +A N+ +KG + ++ + DA A K+ + P +I
Sbjct: 6 IGLIGLGVMGSNLALNIAEKGNRIAVFNRTVDATRKFYAEAGALKDQIVPCETIEEFVAA 65
Query: 314 XXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 493
I+ K V + + H KG ++ID+ + + F + GL F
Sbjct: 66 IRPPRPIIIMIKAGDPVDQQMEALKPHLAKGDIMIDAGNANFRDTMRRFDALKDSGLTFI 125
Query: 494 DAPVSGGVMGAXNATLAFMAGGRKEDFER 580
VSGG GA + + M GG +E + R
Sbjct: 126 GMGVSGGEEGARHGP-SIMVGGTEESYRR 153
>UniRef50_Q4Q9Z1 Cluster: Dehydrogenase-like protein; n=6;
Trypanosomatidae|Rep: Dehydrogenase-like protein -
Leishmania major
Length = 431
Score = 51.2 bits (117), Expect = 2e-05
Identities = 41/159 (25%), Positives = 69/159 (43%), Gaps = 15/159 (9%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTV-------RGYDPSKDALNAAAKNGVTPANSIXXXX 307
NV +G+GNMG + NL K + R ++ + + +G T A I
Sbjct: 9 NVGVVGMGNMGIPITRNLAFKARSAMYLQIHSRTLSKARQVCDDMSADGATCAMRIHDRY 68
Query: 308 XXXXXXXSIL--------TSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFP 463
++ S KV+L+ + +V +A+ G +++D +T+D + ++
Sbjct: 69 STMTKWCDVILLTLAHRAASRKVLLE---DSEALVTNARPGQIIVDHTTVDMELSRECAH 125
Query: 464 IALEKGLGFTDAPVSGGVMGAXNATLAFMAGGRKEDFER 580
A +G F DAP+SG A N L M GG E +R
Sbjct: 126 EAERRGAVFLDAPMSGSPKQAFNNQLVLMVGGPAEQVQR 164
>UniRef50_Q9HLR4 Cluster: Putative uncharacterized protein Ta0161;
n=2; Thermoplasma|Rep: Putative uncharacterized protein
Ta0161 - Thermoplasma acidophilum
Length = 290
Score = 51.2 bits (117), Expect = 2e-05
Identities = 42/139 (30%), Positives = 59/139 (42%), Gaps = 1/139 (0%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKD-ALNAAAKNGVTPANSIXXXXXXXXX 322
K V +GLG MG +AAN G YD + D A N A+ V +
Sbjct: 8 KKVLLVGLGVMGSRIAANFASAGKLAGVYDRNVDKAKNTASMLKVGFYRDLGEAVKNSDI 67
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
++L ++ V +VY + V +G + ID STI P+ +I EKG DAP
Sbjct: 68 IVTMLYDDRSVKEVYSQMEQGV----QGKVFIDMSTISPDTSIEIAKRIKEKGGKMYDAP 123
Query: 503 VSGGVMGAXNATLAFMAGG 559
V G + L + GG
Sbjct: 124 VIGTSIAVEKKALVVLVGG 142
>UniRef50_Q3W031 Cluster: Putative dehydrogenase; n=1; Frankia sp.
EAN1pec|Rep: Putative dehydrogenase - Frankia sp.
EAN1pec
Length = 285
Score = 50.8 bits (116), Expect = 3e-05
Identities = 38/140 (27%), Positives = 58/140 (41%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
VAFLGLG MG MA +++ G + ++ + G + A
Sbjct: 3 VAFLGLGRMGVRMAHHILAAGHELAVWNRTPGRAGELTARGASEAADPAGAVRGADACVL 62
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L DV V+ A G L+I+ +T+ P ++ +AL GL + DAPV G
Sbjct: 63 MLFDPASAADVLA---AVIPAAPPGLLVINCTTVGPAAAREQGSVALAAGLRYLDAPVIG 119
Query: 512 GVMGAXNATLAFMAGGRKED 571
+ A TL + G D
Sbjct: 120 TIGPAEAGTLRVLVGAADAD 139
>UniRef50_Q220G7 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding precursor; n=1; Rhodoferax ferrireducens
T118|Rep: 6-phosphogluconate dehydrogenase, NAD-binding
precursor - Rhodoferax ferrireducens (strain DSM 15236 /
ATCC BAA-621 / T118)
Length = 284
Score = 50.8 bits (116), Expect = 3e-05
Identities = 40/142 (28%), Positives = 60/142 (42%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+AFLG G +GG A K+G TV ++ S D ++A A+ GV A +
Sbjct: 4 IAFLGTGLLGGAFAEAAAKRGDTVTAWNRSPDKVHALAQFGVMAAANPAEAVQSAARVHL 63
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L + VV +V A +++ID +T P + +G+ + PV
Sbjct: 64 VLKDDAVVEEVLA---AARAGLSPDAIIIDHTTTLPTLTAARAERLHAEGVKYLHCPVFM 120
Query: 512 GVMGAXNATLAFMAGGRKEDFE 577
G A NA M G K FE
Sbjct: 121 GPPAARNAQGTMMVAGPKALFE 142
>UniRef50_A3ET09 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=3;
Bacteria|Rep: 3-hydroxyisobutyrate dehydrogenase -
Leptospirillum sp. Group II UBA
Length = 311
Score = 50.4 bits (115), Expect = 4e-05
Identities = 31/142 (21%), Positives = 66/142 (46%), Gaps = 2/142 (1%)
Frame = +2
Query: 161 LGLGNMGGFMAANLVKKGFTVRG-YDPSKDALNAAA-KNGVTPANSIXXXXXXXXXXXSI 334
+G+G MG MA L G+ V YD +A A + G + A ++ ++
Sbjct: 14 VGVGRMGSNMALRLNDVGYRVASVYDVRLEAARRVADETGASVARTLAEVTAQSDVIITV 73
Query: 335 LTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGG 514
+ +++ + ++ + G + ++ +T+ P++ ++ + ++G +A ++
Sbjct: 74 VGTDREMDALFAETGDSLLVGASGRVFVNCATLSPDIHVEVERRSNDRGADCLEASMASS 133
Query: 515 VMGAXNATLAFMAGGRKEDFER 580
+ A TL M GG+KE FER
Sbjct: 134 ITQAREGTLYLMVGGKKEAFER 155
>UniRef50_Q8F4I7 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=4;
Leptospira|Rep: 3-hydroxyisobutyrate dehydrogenase -
Leptospira interrogans
Length = 296
Score = 50.0 bits (114), Expect = 5e-05
Identities = 35/142 (24%), Positives = 65/142 (45%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
++ +G G MG MA NL K G ++R Y + + K+ V +S
Sbjct: 7 ISIIGTGIMGRGMAVNLAKAGHSLRLYTRNLSKIQDLKKDNVQIFDSPIEAAKNSDLVVL 66
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
LT +++V + G++ K +LID T ++ ++ + EK + F D+P++G
Sbjct: 67 CLTEDQIVEKETISS-GLLD--TKPPILIDCGTTSLSLTLKLSKLCSEKKIRFYDSPMTG 123
Query: 512 GVMGAXNATLAFMAGGRKEDFE 577
A + + FM G ++ D +
Sbjct: 124 SKNAARDGQILFMIGAKQVDIK 145
>UniRef50_Q7VYY0 Cluster: Putative oxidoreductase; n=4;
Bordetella|Rep: Putative oxidoreductase - Bordetella
pertussis
Length = 305
Score = 50.0 bits (114), Expect = 5e-05
Identities = 41/153 (26%), Positives = 67/153 (43%), Gaps = 8/153 (5%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLV-KKGFTVRGYDPSKDALNAAAKNGV----TPANSIXXXXX 310
+ + F+GLG MG M NL + + + YD S A + A +
Sbjct: 3 QTLGFVGLGMMGLPMLENLAGDERWQILAYDRSPAPFERLAGHPAWGKRLRAAAGLQELA 62
Query: 311 XXXXXXSILTSNKVVLDVYLGKDG---VVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKG 481
++L ++ + V LG DG ++ + G+ ++D + +P +++ +G
Sbjct: 63 ACDTVITMLPNSAITNAVVLGGDGQPGLIDLLESGAAIVDMGSSNPADTRRLSEQLAARG 122
Query: 482 LGFTDAPVSGGVMGAXNATLAFMAGGRKEDFER 580
L DAPVSG V A TLA MAG + D R
Sbjct: 123 LTLIDAPVSGAVAKASTGTLAIMAGAAEADLRR 155
>UniRef50_Q21ZT0 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Rhodoferax ferrireducens T118|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Rhodoferax ferrireducens (strain DSM 15236 / ATCC
BAA-621 / T118)
Length = 315
Score = 50.0 bits (114), Expect = 5e-05
Identities = 36/140 (25%), Positives = 64/140 (45%), Gaps = 2/140 (1%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYD-PSKDALNAAAKNGV-TPANSIXXXXXXXX 319
+ + F+G+G MG +A NL+K+G + D P ++ K G T A
Sbjct: 5 RKLGFIGVGLMGHGLAKNLLKQGHAMTLLDHPGNQPIDDLMKMGAQTVATPKEVATAADV 64
Query: 320 XXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 499
+ S +V VY G DG++ + G +++D++T DP ++ +G + DA
Sbjct: 65 VFLCVNGSPQVEACVY-GADGLLEGLRAGGVVVDATTADPVSTLKVAAAVQARGGRYVDA 123
Query: 500 PVSGGVMGAXNATLAFMAGG 559
P++ A + + M GG
Sbjct: 124 PMTRTSQHAEDGCVNAMLGG 143
>UniRef50_A3ES45 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Leptospirillum sp. Group II UBA|Rep:
3-hydroxyisobutyrate dehydrogenase - Leptospirillum sp.
Group II UBA
Length = 307
Score = 50.0 bits (114), Expect = 5e-05
Identities = 33/144 (22%), Positives = 59/144 (40%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXX 325
K ++G GNMG MA NL++ G + ++ + L K G +
Sbjct: 12 KEAVWIGTGNMGLPMAKNLLRSGIRLGVHNRTPQRLAPLLKAGAHAIADLRGSLSGTPLV 71
Query: 326 XSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
++L + V + L + G++ +G + + T+ P ++ E+G APV
Sbjct: 72 FTMLADDAAVKETVLKEGGLLDSLPQGGVHVSMGTLSPGFVLELSKTHTERGQILVSAPV 131
Query: 506 SGGVMGAXNATLAFMAGGRKEDFE 577
G A TL +A G ++ E
Sbjct: 132 FGRPDRAEAGTLTIVAAGPQKTLE 155
>UniRef50_Q9V8M5-2 Cluster: Isoform C of Q9V8M5 ; n=1; Drosophila
melanogaster|Rep: Isoform C of Q9V8M5 - Drosophila
melanogaster (Fruit fly)
Length = 227
Score = 49.6 bits (113), Expect = 6e-05
Identities = 24/57 (42%), Positives = 32/57 (56%)
Frame = +2
Query: 110 TAARRAYSSNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVT 280
T R + KN+ F+GLGNMG MA+NL+K G + +D SK A + A G T
Sbjct: 17 TLVRAMSTQGGAKNIGFVGLGNMGANMASNLIKAGHKLHVFDISKPACDGLAAKGAT 73
>UniRef50_A1UJF3 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=4; Actinomycetales|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Mycobacterium sp. (strain KMS)
Length = 272
Score = 49.6 bits (113), Expect = 6e-05
Identities = 38/145 (26%), Positives = 59/145 (40%), Gaps = 1/145 (0%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGV-TPANSIXXXXXXXXXXX 328
V F+G G MG M LV G TV + + AA+ G T A +
Sbjct: 4 VGFVGAGRMGAPMVRRLVGAGHTVTALGRTPEKRAAASDLGAATAAEPVDVATGADIVVV 63
Query: 329 SILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVS 508
+ T ++V G G++A G+ L+ +T P+ + + + G+ DAPVS
Sbjct: 64 CVFTDDQVRAVCLDG--GLLAAMAPGATLVIHTTGSPDTARLLAARGRDHGVDVVDAPVS 121
Query: 509 GGVMGAXNATLAFMAGGRKEDFERS 583
GG + GG + ER+
Sbjct: 122 GGPHDIAAGAVTLFVGGSEAAVERA 146
>UniRef50_Q5GUM4 Cluster: Dehydrogenase; n=5;
Gammaproteobacteria|Rep: Dehydrogenase - Xanthomonas
oryzae pv. oryzae
Length = 335
Score = 49.2 bits (112), Expect = 9e-05
Identities = 38/136 (27%), Positives = 60/136 (44%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ FLGLG MG MA NL++ GF + ++ S + G T S
Sbjct: 46 IGFLGLGTMGLPMAHNLLRGGFELSVWNRSPERAQPLRDAGATVVEQ-PCGAAHGPLLFS 104
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L + V L + GV+ GS+ ++ +TI + + + E+G+ + APV G
Sbjct: 105 MLADDDAVRQTLLER-GVLDALPAGSVHVNMATISVALAHALTALHAERGVAYVAAPVLG 163
Query: 512 GVMGAXNATLAFMAGG 559
V A L +AGG
Sbjct: 164 RVDVAEAGKLNILAGG 179
>UniRef50_Q0C8I2 Cluster: Predicted protein; n=3;
Pezizomycotina|Rep: Predicted protein - Aspergillus
terreus (strain NIH 2624)
Length = 320
Score = 49.2 bits (112), Expect = 9e-05
Identities = 46/156 (29%), Positives = 66/156 (42%), Gaps = 9/156 (5%)
Frame = +2
Query: 131 SSNTDKNVAFLGLGNMGGFMAANLVKK---GFTVRGYDPSKDALN---AAAKNGVTPANS 292
SS + ++ F+GLG MG MA L+ + +D + A+N A + S
Sbjct: 2 SSLSSDDIGFIGLGAMGLPMAQQLIANVPAPTRLYVFDIADQAMNDFVAMYPHKAVAGKS 61
Query: 293 IXXXXXXXXXXXSILTSNKVVLDVYLGKD-GVVAHAKKGSLLIDSSTIDP--NVPKQIFP 463
+++ V VYL + GV + LLID STID ++ +
Sbjct: 62 PRDVAEHSKTIITMVPEGSHVRAVYLDESTGVCSTPLDTRLLIDCSTIDTATSLAVKAHI 121
Query: 464 IALEKGLGFTDAPVSGGVMGAXNATLAFMAGGRKED 571
F DAPVSGGV+GA +AF G K D
Sbjct: 122 TTHHASASFYDAPVSGGVLGAQKGAIAFFLGCAKTD 157
>UniRef50_Q6KZX0 Cluster: 2-hydroxy-3-oxopropionate reductase; n=1;
Picrophilus torridus|Rep: 2-hydroxy-3-oxopropionate
reductase - Picrophilus torridus
Length = 280
Score = 48.8 bits (111), Expect = 1e-04
Identities = 44/146 (30%), Positives = 62/146 (42%), Gaps = 2/146 (1%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNA--AAKNGVTPANSIXXXXXXXXX 322
NV LGLG MG MA L+KK F V GYD +K A KN PA SI
Sbjct: 2 NVGVLGLGRMGSGMAYTLLKKNFNVTGYDVNKMAYGRFNGIKN-FKPAESIDDLYNNDAV 60
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
S+ T +V K + ++ K S++ID++T+D + I + +
Sbjct: 61 IFSLPTGLEV-------KQALSSYNNK-SIIIDTTTLDIRELHENLAI-INNSKNYLTCR 111
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFER 580
+ G A LA GG E + +
Sbjct: 112 LERGPKEANEGDLAMFVGGDMETYNK 137
>UniRef50_Q0BTJ3 Cluster: 2-hydroxy-3-oxopropionate reductase; n=1;
Granulibacter bethesdensis CGDNIH1|Rep:
2-hydroxy-3-oxopropionate reductase - Granulobacter
bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Length = 293
Score = 48.4 bits (110), Expect = 1e-04
Identities = 44/143 (30%), Positives = 62/143 (43%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+A LG G MG +MA L G V ++ + AA+ G+ A S
Sbjct: 9 IAVLGTGIMGRWMACRLADAGHEVTVWNRNPVR---AAELGLPVATSAPDAAHGADVAL- 64
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
++ S+ D L V A+ G++L+ SS Q ++ + DAPVSG
Sbjct: 65 LMVSDGPACDAVLETGFVDTMAQNGTVLVMSSIEPWRARAQAKKVSPRF---YVDAPVSG 121
Query: 512 GVMGAXNATLAFMAGGRKEDFER 580
G GA N TLA MAGG + R
Sbjct: 122 GEGGARNGTLAIMAGGEEAVLNR 144
>UniRef50_A5CN67 Cluster: Putative beta-hydroxyacid dehydrogenase;
n=1; Clavibacter michiganensis subsp. michiganensis
NCPPB 382|Rep: Putative beta-hydroxyacid dehydrogenase -
Clavibacter michiganensis subsp. michiganensis (strain
NCPPB 382)
Length = 291
Score = 48.4 bits (110), Expect = 1e-04
Identities = 35/140 (25%), Positives = 60/140 (42%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ LG G MG M+ ++++ G + ++ S + A G T A S
Sbjct: 1 MTLLGTGVMGSGMSRSILRAGLPLTVWNRSAEKAAPLADAGATVAESAADAVRDADVVVV 60
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+L VL+V V + G++++ SST+ ++I +A E + F DAPV G
Sbjct: 61 MLFDADAVLEVLAE---VAPALRPGAVVLQSSTVGVEGTRRIAALAAEHAVRFVDAPVLG 117
Query: 512 GVMGAXNATLAFMAGGRKED 571
A L + G ++D
Sbjct: 118 TRGPAEQGLLVHLVSGSEDD 137
>UniRef50_A4FKN9 Cluster: 2-hydroxy-3-oxopropionate reductase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep:
2-hydroxy-3-oxopropionate reductase - Saccharopolyspora
erythraea (strain NRRL 23338)
Length = 297
Score = 48.4 bits (110), Expect = 1e-04
Identities = 39/144 (27%), Positives = 61/144 (42%), Gaps = 4/144 (2%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V +GLG MG +A L + G V S+ AAA+ GV + +
Sbjct: 5 VGVIGLGPMGANLALRLAEAGLDVVATSRSQGTREAAAREGVRVVDDVRALAGRLRAASP 64
Query: 332 ---ILTSNKVVLDVYLGK-DGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDA 499
++ S V DG++A + +++D+ST P + + +G DA
Sbjct: 65 KPVVVVSLPSGPQVRAAVVDGLLADGGE-FVVVDTSTCAPADARSLADDLHARGCAVVDA 123
Query: 500 PVSGGVMGAXNATLAFMAGGRKED 571
PVSGG A +L+ M GG + D
Sbjct: 124 PVSGGPTAARAGSLSVMVGGTEAD 147
>UniRef50_Q5LNV6 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=2;
Rhodobacteraceae|Rep: 3-hydroxyisobutyrate dehydrogenase
- Silicibacter pomeroyi
Length = 269
Score = 48.0 bits (109), Expect = 2e-04
Identities = 36/142 (25%), Positives = 59/142 (41%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ G G MG M A L + GF +G+D + +G+T + + +
Sbjct: 2 IGVAGCGRMGAPMLAALRRAGFQAQGFDIRPSSDFPGTDHGIT--DGVAVFSQNLCTLIT 59
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
++ V L D + HAK +I ST+ P + + + + DAP+SG
Sbjct: 60 VVRDISQTEQV-LFTDQKLIHAKHLDCVIICSTLSPRYVRDL-RARVPDHIALIDAPMSG 117
Query: 512 GVMGAXNATLAFMAGGRKEDFE 577
+ A A L+FM GG D +
Sbjct: 118 AQIAAQEARLSFMLGGEPADLD 139
>UniRef50_Q0RIL5 Cluster: Putative uncharacterized protein; n=1;
Frankia alni ACN14a|Rep: Putative uncharacterized
protein - Frankia alni (strain ACN14a)
Length = 493
Score = 48.0 bits (109), Expect = 2e-04
Identities = 32/132 (24%), Positives = 63/132 (47%)
Frame = +2
Query: 161 LGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXSILT 340
+GLG +GG +A ++ ++G +D DA A G + +++T
Sbjct: 13 VGLGMIGGGVAVSMARRGRVPAVHDVRPDASAALPGVGDPLGSPAEVARSSDVVMVAVVT 72
Query: 341 SNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSGGVM 520
+++ DV G++G++A A G ++ ST++ V ++ + E +GF D V+ G
Sbjct: 73 ADQA-RDVIGGENGLLAGAHPGLTIVLLSTVELAVVHELAALCAEHDVGFLDCGVTPGDR 131
Query: 521 GAXNATLAFMAG 556
A + +A + G
Sbjct: 132 AADHGMVAIVGG 143
>UniRef50_A3Q3U7 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=3; Mycobacterium|Rep: 6-phosphogluconate
dehydrogenase, NAD-binding - Mycobacterium sp. (strain
JLS)
Length = 279
Score = 48.0 bits (109), Expect = 2e-04
Identities = 38/136 (27%), Positives = 53/136 (38%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V FLG G +G M L+ G V Y +DA G A+S+ S
Sbjct: 5 VGFLGAGQLGEPMVERLLGAGHDVLVYARREDARRRLEAKGAALADSVADLAHGSDVLIS 64
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
L S+ + + LG +G +A+AK ++ + S T G DAPVSG
Sbjct: 65 CLFSDAQLRETGLGPNGFIANAKPAAVFV-SHTTGTVATLTALRDHSSSGPVVLDAPVSG 123
Query: 512 GVMGAXNATLAFMAGG 559
TL + GG
Sbjct: 124 TADDIAAGTLTVLLGG 139
>UniRef50_Q0U6Q6 Cluster: Putative uncharacterized protein; n=5;
Pezizomycotina|Rep: Putative uncharacterized protein -
Phaeosphaeria nodorum (Septoria nodorum)
Length = 311
Score = 48.0 bits (109), Expect = 2e-04
Identities = 42/149 (28%), Positives = 60/149 (40%), Gaps = 11/149 (7%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGF----------TVRGYDPSKDALNAAAKNGVTPA-NSIX 298
+A+LGLGNMG M NLV+KG T + D D + + +G T ++I
Sbjct: 5 LAWLGLGNMGRGMCKNLVEKGNLDKPLIIYNRTKKRSDDLSDKIASDVGSGKTKVVDTIN 64
Query: 299 XXXXXXXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEK 478
L + V D ++ KG L++D ST+ P+ + EK
Sbjct: 65 AATKEADIIFMCLGDDAAVNSTV---DTILQEDTKGKLIVDCSTVHPDTTNALEKRITEK 121
Query: 479 GLGFTDAPVSGGVMGAXNATLAFMAGGRK 565
G F PV G A N L + G K
Sbjct: 122 GAEFVGMPVFGAPAMADNGQLVCVIAGTK 150
>UniRef50_Q9RU02 Cluster: 6-phosphogluconate dehydrogenase; n=24;
Bacteria|Rep: 6-phosphogluconate dehydrogenase -
Deinococcus radiodurans
Length = 368
Score = 47.6 bits (108), Expect = 3e-04
Identities = 40/149 (26%), Positives = 59/149 (39%), Gaps = 6/149 (4%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ +GLG MGG M L G V G+D S++A++ GV A+++
Sbjct: 5 IGMIGLGKMGGNMVIRLKNGGQDVVGFDRSQEAIDHLVSQGVA-ADALTSDMDRFIELLG 63
Query: 332 ILTSNKVVLDVYLGK------DGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 493
V + V G+ D + G ++ID + + ++ KGL F
Sbjct: 64 EPGQRAVWVMVPAGQITQSVIDDLAGRLSAGDVIIDGGNSNFHDTQRRGEALAAKGLHFV 123
Query: 494 DAPVSGGVMGAXNATLAFMAGGRKEDFER 580
D SGGV G M GG E ER
Sbjct: 124 DVGTSGGVWGITEG-YGMMVGGPDEGVER 151
>UniRef50_Q1V2K7 Cluster: NADP oxidoreductase, coenzyme
F420-dependent:6- phosphogluconatedehydrogenase,
NAD-binding:3-hydroxyacyl-CoA; n=1; Candidatus
Pelagibacter ubique HTCC1002|Rep: NADP oxidoreductase,
coenzyme F420-dependent:6-
phosphogluconatedehydrogenase,
NAD-binding:3-hydroxyacyl-CoA - Candidatus Pelagibacter
ubique HTCC1002
Length = 284
Score = 47.2 bits (107), Expect = 3e-04
Identities = 34/147 (23%), Positives = 63/147 (42%), Gaps = 1/147 (0%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVK-KGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXX 322
KNV F+G+G MG +A N++K K + ++ + G S
Sbjct: 2 KNVGFIGVGYMGYGIAKNILKNKNNLFVIANKNRSPIEKIVSEGAVEVKSYDELCSKDLD 61
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
+ +N + + K ++ +L+ID +T D N + I K + + + P
Sbjct: 62 CLFLCVTNTPIAHSIIEK--ILPLLNSDTLIIDITTHDQNGSIEANKIFKSKNINYIECP 119
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFERS 583
V GG + A L + GG +E+F+++
Sbjct: 120 VMGGPVQAEEGVLGGIIGGSEENFKKA 146
>UniRef50_Q1INE9 Cluster: 6-phosphogluconate dehydrogenase,
NAD-binding; n=1; Acidobacteria bacterium Ellin345|Rep:
6-phosphogluconate dehydrogenase, NAD-binding -
Acidobacteria bacterium (strain Ellin345)
Length = 313
Score = 47.2 bits (107), Expect = 3e-04
Identities = 35/136 (25%), Positives = 59/136 (43%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
V FLGLGNMG MAANL+ G V ++ + + GV A I +
Sbjct: 25 VGFLGLGNMGEPMAANLIAAGHQVTVWNRTAAKAEPLKERGVKVATEIKDAVQNQDVVCT 84
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
++ + + + G G++ KG++ + ST+ + +++ ++G F APV G
Sbjct: 85 MVADDHALRTILEG--GLLEALPKGAVHVSHSTVSVAMAEELKREHGKRGQAFISAPVFG 142
Query: 512 GVMGAXNATLAFMAGG 559
A L + G
Sbjct: 143 RPEAAQAKKLFVVVSG 158
>UniRef50_Q1GM24 Cluster: 6-phosphogluconate dehydrogenase
NAD-binding; n=3; Rhodobacteraceae|Rep:
6-phosphogluconate dehydrogenase NAD-binding -
Silicibacter sp. (strain TM1040)
Length = 292
Score = 47.2 bits (107), Expect = 3e-04
Identities = 33/146 (22%), Positives = 60/146 (41%), Gaps = 2/146 (1%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKG-FTVRGYD-PSKDALNAAAKNGVTPANSIXXXXXXXXX 322
+V +G+G MG +A N++ +G F + D P ++ G +
Sbjct: 2 HVGIIGVGLMGHGIARNVLSRGGFALSFLDHPGNQPVDEIVSLGAVACATPAEVAAMSDV 61
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
+T + V + G GV ++ ++++D ST P ++ I G + DAP
Sbjct: 62 VILCVTGSPQVEAIVAGDQGVATALRQNAVIVDCSTALPESTLRMAEIVRAAGGDYLDAP 121
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFER 580
++ A TL + GG + ER
Sbjct: 122 MTRTARHAHEGTLNLLVGGATDTLER 147
>UniRef50_Q97ZE5 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=4;
Sulfolobaceae|Rep: 3-hydroxyisobutyrate dehydrogenase -
Sulfolobus solfataricus
Length = 289
Score = 47.2 bits (107), Expect = 3e-04
Identities = 40/144 (27%), Positives = 60/144 (41%), Gaps = 2/144 (1%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ +GLG MG +AANL K YD +++ + + K N +
Sbjct: 3 IGLIGLGIMGYRIAANLAKANKLNLVYDRTQEKIESFVKE--YKVNGVQNTKDLVESSDV 60
Query: 332 ILTSNKVVLDVYLGKDGV--VAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
I+T ++ D Y K V + KG +LID STI P + + G DAPV
Sbjct: 61 IIT---MLADDYAVKSVVEPLIPLMKGKILIDMSTISPTLSISLAKRIESNGGTMFDAPV 117
Query: 506 SGGVMGAXNATLAFMAGGRKEDFE 577
G + L + GG K+ F+
Sbjct: 118 IGTSVFVEQKKLVVLVGGPKDKFD 141
>UniRef50_O66788 Cluster: 6-phosphogluconate dehydrogenase; n=2;
Aquifex aeolicus|Rep: 6-phosphogluconate dehydrogenase -
Aquifex aeolicus
Length = 300
Score = 46.8 bits (106), Expect = 5e-04
Identities = 37/146 (25%), Positives = 61/146 (41%), Gaps = 1/146 (0%)
Frame = +2
Query: 146 KNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKN-GVTPANSIXXXXXXXXX 322
K + +GLG MG +A L +G+ + GY ++ A K+ G+ NS
Sbjct: 2 KTLFLIGLGRMGSALAYRLKNRGWEIYGYSRTQTTRERAKKDLGIKVLNSYENLKNFPSP 61
Query: 323 XXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAP 502
L +D L + KG +ID ++ + E + F D
Sbjct: 62 KTVWLMVPHTAVDEVL--QNLKPFLNKGDTVIDGGNSYYKDSQRRYRELKEVDVNFLDVG 119
Query: 503 VSGGVMGAXNATLAFMAGGRKEDFER 580
VSGG++G + +FM GG +E F++
Sbjct: 120 VSGGILG-KDTGFSFMIGGDEEVFKK 144
>UniRef50_Q6D9X4 Cluster: Putative 2-hydroxy-3-oxopropionate
reductase; n=1; Pectobacterium atrosepticum|Rep:
Putative 2-hydroxy-3-oxopropionate reductase - Erwinia
carotovora subsp. atroseptica (Pectobacterium
atrosepticum)
Length = 297
Score = 46.4 bits (105), Expect = 6e-04
Identities = 32/143 (22%), Positives = 62/143 (43%), Gaps = 1/143 (0%)
Frame = +2
Query: 149 NVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXX 328
+V+ +G+G +G ++ L+++ F++ ++ + N A G +
Sbjct: 4 SVSLVGVGVLGKAISLRLLQRHFSLSVFNRTHSKTNDVAAEGAQAVPELHQLFTQEKQIV 63
Query: 329 SI-LTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPV 505
I L + + DV+ +D + + L ++ STI P + + + G + + PV
Sbjct: 64 LICLKDAEAIRDVFQSEDVIHKLSLYRPLFLNISTIGPEESRWMETFFHQHGAHYVECPV 123
Query: 506 SGGVMGAXNATLAFMAGGRKEDF 574
SGG GA LA G +DF
Sbjct: 124 SGGPEGARQGRLAAWVGPYADDF 146
>UniRef50_Q0W2D7 Cluster: Putative 6-phosphogluconate dehydrogenase;
n=1; uncultured methanogenic archaeon RC-I|Rep: Putative
6-phosphogluconate dehydrogenase - Uncultured
methanogenic archaeon RC-I
Length = 310
Score = 46.4 bits (105), Expect = 6e-04
Identities = 40/144 (27%), Positives = 63/144 (43%), Gaps = 2/144 (1%)
Frame = +2
Query: 152 VAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXXXXXXXS 331
+ +GLG MGG +A V+KG V + SK + A G+ A++
Sbjct: 3 LGIIGLGRMGGSLALQAVEKGVEVVAH--SKHSHPDFATRGIHIADTYEEFARLLRTPRI 60
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLID--SSTIDPNVPKQIFPIALEKGLGFTDAPV 505
I S + + ++ H ++G +L+D +S +V ++ +KG D
Sbjct: 61 IYLSLPAGQIIDQVIESLIPHLERGDVLMDGGNSFFRDSVARE--EALRKKGFRLLDCGT 118
Query: 506 SGGVMGAXNATLAFMAGGRKEDFE 577
SGGV GA FM GG +E FE
Sbjct: 119 SGGVDGARTGA-CFMVGGSREGFE 141
>UniRef50_Q3J9H5 Cluster: 6-phosphogluconate dehydrogenase,
decarboxylating; n=2; Bacteria|Rep: 6-phosphogluconate
dehydrogenase, decarboxylating - Nitrosococcus oceani
(strain ATCC 19707 / NCIMB 11848)
Length = 481
Score = 46.0 bits (104), Expect = 8e-04
Identities = 42/158 (26%), Positives = 67/158 (42%), Gaps = 9/158 (5%)
Frame = +2
Query: 134 SNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYD--PSKDA-LNAAAKNGVTPANSIXXX 304
S T ++ +GLG MG + N+ ++GF V GYD P K A L A+ + +
Sbjct: 6 SPTSADIGIIGLGVMGANLGLNIAEQGFNVAGYDRNPEKGARLTQMAQKQLAEDAPMEAY 65
Query: 305 XXXXXXXXSILTSNKVVLDVYLGK--DGVV----AHAKKGSLLIDSSTIDPNVPKQIFPI 466
S+ ++L V G DGV+ ++G++LID +
Sbjct: 66 HDIQPFIASLRQPRLILLLVPAGDPVDGVIQDLSPDLEQGTILIDGGNSHFRDTDRRIQT 125
Query: 467 ALEKGLGFTDAPVSGGVMGAXNATLAFMAGGRKEDFER 580
++ + F VSGG GA + + M GG +ER
Sbjct: 126 LAQQNVHFVGMGVSGGEAGARHGP-SMMPGGDSTAWER 162
>UniRef50_Q9RBX6 Cluster: IgiB; n=1; Vogesella indigofera|Rep: IgiB
- Pseudomonas indigofera (Vogesella indigofera)
Length = 291
Score = 46.0 bits (104), Expect = 8e-04
Identities = 32/142 (22%), Positives = 57/142 (40%)
Frame = +2
Query: 134 SNTDKNVAFLGLGNMGGFMAANLVKKGFTVRGYDPSKDALNAAAKNGVTPANSIXXXXXX 313
+ T +A LG G +G +A NL KGF V+ ++ + A ++ + S+
Sbjct: 2 NTTTPTIAVLGSGLIGAPVARNLASKGFKVKVWNRTAAKAQALVQDNLQACASVAEAVRD 61
Query: 314 XXXXXSILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFT 493
++L V G H + G+ + ST+ + + +A ++ L +
Sbjct: 62 ADCIVTVLKDGDSVASAMAAGSG---HFRPGAKWLQLSTVGIDAAASLAQLASQQQLVYF 118
Query: 494 DAPVSGGVMGAXNATLAFMAGG 559
D PV G A L +A G
Sbjct: 119 DTPVQGTRQPAEQGQLIILASG 140
>UniRef50_Q4WXG9 Cluster: 3-hydroxyisobutyrate dehydrogenase,
putative; n=1; Aspergillus fumigatus|Rep:
3-hydroxyisobutyrate dehydrogenase, putative -
Aspergillus fumigatus (Sartorya fumigata)
Length = 317
Score = 46.0 bits (104), Expect = 8e-04
Identities = 29/84 (34%), Positives = 42/84 (50%), Gaps = 3/84 (3%)
Frame = +2
Query: 329 SILTSNKVVLDVYLGKD-GVVAHAKKGSLLIDSSTIDPNVPKQIFPIALE--KGLGFTDA 499
+++ + V VYL GV+ + +L+D STID + + K F DA
Sbjct: 84 TMVPEGRHVRSVYLDSHAGVLTTSVDDKILVDCSTIDTATSMDVGAAVCQNSKTAAFYDA 143
Query: 500 PVSGGVMGAXNATLAFMAGGRKED 571
PVSGG +GA TL FM G ++D
Sbjct: 144 PVSGGSLGAVAGTLTFMVGCVEDD 167
>UniRef50_A2BJA4 Cluster: 3-hydroxyisobutyrate dehydrogenase; n=1;
Hyperthermus butylicus DSM 5456|Rep:
3-hydroxyisobutyrate dehydrogenase - Hyperthermus
butylicus (strain DSM 5456 / JCM 9403)
Length = 298
Score = 46.0 bits (104), Expect = 8e-04
Identities = 32/138 (23%), Positives = 58/138 (42%), Gaps = 1/138 (0%)
Frame = +2
Query: 155 AFLGLGNMGGFMAANLVKKGFTVRGYDPSKD-ALNAAAKNGVTPANSIXXXXXXXXXXXS 331
A LGLG MG +A L +GF + ++ ++ A AA+ A S
Sbjct: 6 AVLGLGRMGSAIAERLHDRGFRLVVWNRTRSRAEELAARLDAEVAGSPAGAAEKCNAVHI 65
Query: 332 ILTSNKVVLDVYLGKDGVVAHAKKGSLLIDSSTIDPNVPKQIFPIALEKGLGFTDAPVSG 511
+++ ++ + V G G+ + G L+ + +T+ P + G + +APV G
Sbjct: 66 VVSDDEASMSVIAGPTGITSINLGGRLVYNHTTVTPRHTMLALELVERAGGTYVEAPVLG 125
Query: 512 GVMGAXNATLAFMAGGRK 565
G A L + G ++
Sbjct: 126 GPSAARAGRLVVLCGSKR 143
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 706,559,557
Number of Sequences: 1657284
Number of extensions: 15216664
Number of successful extensions: 46669
Number of sequences better than 10.0: 346
Number of HSP's better than 10.0 without gapping: 44541
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 46514
length of database: 575,637,011
effective HSP length: 98
effective length of database: 413,223,179
effective search space used: 49173558301
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -