Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fprWP01_F_G19
(627 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC063302-1|AAH63302.1| 1278|Homo sapiens Niemann-Pick disease, t... 49 2e-05
AF338230-1|AAK25791.1| 1278|Homo sapiens Niemann-Pick disease C1... 49 2e-05
AF157379-1|AAD48006.1| 1278|Homo sapiens Niemann-Pick C1 protein... 49 2e-05
AF002020-1|AAB63982.1| 1278|Homo sapiens Niemann-Pick C disease ... 49 2e-05
AB209048-1|BAD92285.1| 1289|Homo sapiens Niemann-Pick disease, t... 49 2e-05
BC117178-1|AAI17179.1| 1332|Homo sapiens NPC1L1 protein protein. 39 0.017
AY515256-1|AAS56939.1| 1332|Homo sapiens NPC1L1 splice variant p... 39 0.017
AY437865-1|AAR97886.1| 1332|Homo sapiens Niemann-Pick C1-like 1 ... 39 0.017
AF192523-1|AAF20397.1| 724|Homo sapiens truncated Niemann-Pick ... 39 0.017
AF192522-1|AAF20396.1| 1359|Homo sapiens Niemann-Pick C1-like pr... 39 0.017
M11058-1|AAA52679.1| 888|Homo sapiens HMGCR protein. 32 1.4
BC033692-1|AAH33692.1| 835|Homo sapiens HMGCR protein protein. 32 1.4
AY321356-1|AAP72015.1| 888|Homo sapiens 3-hydroxy-3-methylgluta... 32 1.4
AF273765-1|AAG21343.1| 888|Homo sapiens 3-hydroxy-3-methylgluta... 32 1.4
AF087651-1|AAD25953.1| 1203|Homo sapiens patched 2 protein. 32 1.4
AY438664-1|AAR05447.1| 1203|Homo sapiens patched homolog 2 (Dros... 32 1.9
AY359016-1|AAQ89375.1| 1203|Homo sapiens Patched 2 protein. 32 1.9
AY358555-1|AAQ88919.1| 1211|Homo sapiens Patched 2 protein. 32 1.9
AL592166-5|CAI13000.1| 1203|Homo sapiens patched homolog 2 (Dros... 32 1.9
AL136380-1|CAI23127.1| 1203|Homo sapiens patched homolog 2 (Dros... 32 1.9
AF119569-1|AAD17260.1| 1146|Homo sapiens patched 2 protein. 32 1.9
AF091501-1|AAC79847.1| 1203|Homo sapiens receptor protein patche... 32 1.9
BC084553-1|AAH84553.1| 371|Homo sapiens glutamate receptor, ion... 30 5.8
BC041788-1|AAH41788.2| 371|Homo sapiens glutamate receptor, ion... 30 5.8
AB097026-1|BAC77379.1| 371|Homo sapiens putative MAPK activatin... 30 5.8
>BC063302-1|AAH63302.1| 1278|Homo sapiens Niemann-Pick disease, type
C1 protein.
Length = 1278
Score = 48.8 bits (111), Expect = 2e-05
Identities = 25/86 (29%), Positives = 43/86 (50%)
Frame = +2
Query: 320 VSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS 499
VS+ + +F G F ++P VIF +L+F+T GL+ + NP++LW P S
Sbjct: 327 VSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSS 386
Query: 500 DFYHDTNWYIKTFGTGLRLQNIIFTA 577
+ ++ + FG R + +I A
Sbjct: 387 QARLEKEYFDQHFGPFFRTEQLIIRA 412
>AF338230-1|AAK25791.1| 1278|Homo sapiens Niemann-Pick disease C1
protein protein.
Length = 1278
Score = 48.8 bits (111), Expect = 2e-05
Identities = 25/86 (29%), Positives = 43/86 (50%)
Frame = +2
Query: 320 VSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS 499
VS+ + +F G F ++P VIF +L+F+T GL+ + NP++LW P S
Sbjct: 327 VSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSS 386
Query: 500 DFYHDTNWYIKTFGTGLRLQNIIFTA 577
+ ++ + FG R + +I A
Sbjct: 387 QARLEKEYFDQHFGPFFRTEQLIIRA 412
>AF157379-1|AAD48006.1| 1278|Homo sapiens Niemann-Pick C1 protein
protein.
Length = 1278
Score = 48.8 bits (111), Expect = 2e-05
Identities = 25/86 (29%), Positives = 43/86 (50%)
Frame = +2
Query: 320 VSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS 499
VS+ + +F G F ++P VIF +L+F+T GL+ + NP++LW P S
Sbjct: 327 VSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSS 386
Query: 500 DFYHDTNWYIKTFGTGLRLQNIIFTA 577
+ ++ + FG R + +I A
Sbjct: 387 QARLEKEYFDQHFGPFFRTEQLIIRA 412
>AF002020-1|AAB63982.1| 1278|Homo sapiens Niemann-Pick C disease
protein protein.
Length = 1278
Score = 48.8 bits (111), Expect = 2e-05
Identities = 25/86 (29%), Positives = 43/86 (50%)
Frame = +2
Query: 320 VSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS 499
VS+ + +F G F ++P VIF +L+F+T GL+ + NP++LW P S
Sbjct: 327 VSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSS 386
Query: 500 DFYHDTNWYIKTFGTGLRLQNIIFTA 577
+ ++ + FG R + +I A
Sbjct: 387 QARLEKEYFDQHFGPFFRTEQLIIRA 412
>AB209048-1|BAD92285.1| 1289|Homo sapiens Niemann-Pick disease, type
C1 variant protein.
Length = 1289
Score = 48.8 bits (111), Expect = 2e-05
Identities = 25/86 (29%), Positives = 43/86 (50%)
Frame = +2
Query: 320 VSSVSVHFVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDS 499
VS+ + +F G F ++P VIF +L+F+T GL+ + NP++LW P S
Sbjct: 338 VSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSS 397
Query: 500 DFYHDTNWYIKTFGTGLRLQNIIFTA 577
+ ++ + FG R + +I A
Sbjct: 398 QARLEKEYFDQHFGPFFRTEQLIIRA 423
>BC117178-1|AAI17179.1| 1332|Homo sapiens NPC1L1 protein protein.
Length = 1332
Score = 38.7 bits (86), Expect = 0.017
Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Frame = +2
Query: 326 SVSVHFVESIFFS-LGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSD 502
S S H + FF G +VA P ++ +++ V GL+ + +P+ LW P+S
Sbjct: 330 SFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQ 389
Query: 503 FYHDTNWYIKTFGTGLRLQNIIFTA 577
+ ++ + FG R +I TA
Sbjct: 390 ARSEKAFHDQHFGPFFRTNQVILTA 414
>AY515256-1|AAS56939.1| 1332|Homo sapiens NPC1L1 splice variant
protein.
Length = 1332
Score = 38.7 bits (86), Expect = 0.017
Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Frame = +2
Query: 326 SVSVHFVESIFFS-LGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSD 502
S S H + FF G +VA P ++ +++ V GL+ + +P+ LW P+S
Sbjct: 330 SFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQ 389
Query: 503 FYHDTNWYIKTFGTGLRLQNIIFTA 577
+ ++ + FG R +I TA
Sbjct: 390 ARSEKAFHDQHFGPFFRTNQVILTA 414
>AY437865-1|AAR97886.1| 1332|Homo sapiens Niemann-Pick C1-like 1
protein.
Length = 1332
Score = 38.7 bits (86), Expect = 0.017
Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Frame = +2
Query: 326 SVSVHFVESIFFS-LGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSD 502
S S H + FF G +VA P ++ +++ V GL+ + +P+ LW P+S
Sbjct: 330 SFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQ 389
Query: 503 FYHDTNWYIKTFGTGLRLQNIIFTA 577
+ ++ + FG R +I TA
Sbjct: 390 ARSEKAFHDQHFGPFFRTNQVILTA 414
>AF192523-1|AAF20397.1| 724|Homo sapiens truncated Niemann-Pick
C1-like protein 1 protein.
Length = 724
Score = 38.7 bits (86), Expect = 0.017
Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Frame = +2
Query: 326 SVSVHFVESIFFS-LGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSD 502
S S H + FF G +VA P ++ +++ V GL+ + +P+ LW P+S
Sbjct: 330 SFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQ 389
Query: 503 FYHDTNWYIKTFGTGLRLQNIIFTA 577
+ ++ + FG R +I TA
Sbjct: 390 ARSEKAFHDQHFGPFFRTNQVILTA 414
>AF192522-1|AAF20396.1| 1359|Homo sapiens Niemann-Pick C1-like
protein 1 protein.
Length = 1359
Score = 38.7 bits (86), Expect = 0.017
Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Frame = +2
Query: 326 SVSVHFVESIFFS-LGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSD 502
S S H + FF G +VA P ++ +++ V GL+ + +P+ LW P+S
Sbjct: 330 SFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQ 389
Query: 503 FYHDTNWYIKTFGTGLRLQNIIFTA 577
+ ++ + FG R +I TA
Sbjct: 390 ARSEKAFHDQHFGPFFRTNQVILTA 414
>M11058-1|AAA52679.1| 888|Homo sapiens HMGCR protein.
Length = 888
Score = 32.3 bits (70), Expect = 1.4
Identities = 12/21 (57%), Positives = 16/21 (76%)
Frame = +2
Query: 353 IFFSLGIFVAKHPWQVIFGTL 415
+F G+FVA HPW+VI GT+
Sbjct: 5 LFRMHGLFVASHPWEVIVGTV 25
>BC033692-1|AAH33692.1| 835|Homo sapiens HMGCR protein protein.
Length = 835
Score = 32.3 bits (70), Expect = 1.4
Identities = 12/21 (57%), Positives = 16/21 (76%)
Frame = +2
Query: 353 IFFSLGIFVAKHPWQVIFGTL 415
+F G+FVA HPW+VI GT+
Sbjct: 5 LFRMHGLFVASHPWEVIVGTV 25
>AY321356-1|AAP72015.1| 888|Homo sapiens
3-hydroxy-3-methylglutaryl-Coenzyme A reductase protein.
Length = 888
Score = 32.3 bits (70), Expect = 1.4
Identities = 12/21 (57%), Positives = 16/21 (76%)
Frame = +2
Query: 353 IFFSLGIFVAKHPWQVIFGTL 415
+F G+FVA HPW+VI GT+
Sbjct: 5 LFRMHGLFVASHPWEVIVGTV 25
>AF273765-1|AAG21343.1| 888|Homo sapiens
3-hydroxy-3-methylglutaryl-coenzyme A reductase protein.
Length = 888
Score = 32.3 bits (70), Expect = 1.4
Identities = 12/21 (57%), Positives = 16/21 (76%)
Frame = +2
Query: 353 IFFSLGIFVAKHPWQVIFGTL 415
+F G+FVA HPW+VI GT+
Sbjct: 5 LFRMHGLFVASHPWEVIVGTV 25
>AF087651-1|AAD25953.1| 1203|Homo sapiens patched 2 protein.
Length = 1203
Score = 32.3 bits (70), Expect = 1.4
Identities = 24/94 (25%), Positives = 42/94 (44%), Gaps = 6/94 (6%)
Frame = +2
Query: 341 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 520
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 521 WYIKTFG------TGLRLQNIIFTANDILHPDVL 604
+ + G + + +Q + +IL P+ L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTALQEGENILTPEAL 132
>AY438664-1|AAR05447.1| 1203|Homo sapiens patched homolog 2
(Drosophila) protein.
Length = 1203
Score = 31.9 bits (69), Expect = 1.9
Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 6/94 (6%)
Frame = +2
Query: 341 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 520
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 521 WYIKTFG--TGLRLQNIIFTA----NDILHPDVL 604
+ + G Q +I TA +IL P+ L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEAL 132
>AY359016-1|AAQ89375.1| 1203|Homo sapiens Patched 2 protein.
Length = 1203
Score = 31.9 bits (69), Expect = 1.9
Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 6/94 (6%)
Frame = +2
Query: 341 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 520
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 521 WYIKTFG--TGLRLQNIIFTA----NDILHPDVL 604
+ + G Q +I TA +IL P+ L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEAL 132
>AY358555-1|AAQ88919.1| 1211|Homo sapiens Patched 2 protein.
Length = 1211
Score = 31.9 bits (69), Expect = 1.9
Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 6/94 (6%)
Frame = +2
Query: 341 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 520
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 521 WYIKTFG--TGLRLQNIIFTA----NDILHPDVL 604
+ + G Q +I TA +IL P+ L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEAL 132
>AL592166-5|CAI13000.1| 1203|Homo sapiens patched homolog 2
(Drosophila) protein.
Length = 1203
Score = 31.9 bits (69), Expect = 1.9
Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 6/94 (6%)
Frame = +2
Query: 341 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 520
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 521 WYIKTFG--TGLRLQNIIFTA----NDILHPDVL 604
+ + G Q +I TA +IL P+ L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEAL 132
>AL136380-1|CAI23127.1| 1203|Homo sapiens patched homolog 2
(Drosophila) protein.
Length = 1203
Score = 31.9 bits (69), Expect = 1.9
Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 6/94 (6%)
Frame = +2
Query: 341 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 520
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 521 WYIKTFG--TGLRLQNIIFTA----NDILHPDVL 604
+ + G Q +I TA +IL P+ L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEAL 132
>AF119569-1|AAD17260.1| 1146|Homo sapiens patched 2 protein.
Length = 1146
Score = 31.9 bits (69), Expect = 1.9
Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 6/94 (6%)
Frame = +2
Query: 341 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 520
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 521 WYIKTFG--TGLRLQNIIFTA----NDILHPDVL 604
+ + G Q +I TA +IL P+ L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEAL 132
>AF091501-1|AAC79847.1| 1203|Homo sapiens receptor protein patched 2
protein.
Length = 1203
Score = 31.9 bits (69), Expect = 1.9
Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 6/94 (6%)
Frame = +2
Query: 341 FVESIFFSLGIFVAKHPWQVIFGTLLFVTVSCIGLIRFHIEKNPMNLWVPPDSDFYHDTN 520
+ + + FSLG + +H +V+F LL +GL IE N LWV S + +
Sbjct: 39 YFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELH 98
Query: 521 WYIKTFG--TGLRLQNIIFTA----NDILHPDVL 604
+ + G Q +I TA +IL P+ L
Sbjct: 99 YTKEKLGEEAAYTSQMLIQTARQEGENILTPEAL 132
>BC084553-1|AAH84553.1| 371|Homo sapiens glutamate receptor,
ionotropic, N-methyl D-asparate-associated protein 1
(gluta protein.
Length = 371
Score = 30.3 bits (65), Expect = 5.8
Identities = 16/51 (31%), Positives = 28/51 (54%), Gaps = 2/51 (3%)
Frame = +2
Query: 302 QQIWEGVSSVSVHFVESIFFSL-GIFVAKHPWQVIFGTLLFVTVS-CIGLI 448
+ +W S +V F+ I S G F KHPW ++ ++L ++S +G+I
Sbjct: 195 ENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVALSVLTASLSYMVGMI 245
>BC041788-1|AAH41788.2| 371|Homo sapiens glutamate receptor,
ionotropic, N-methyl D-asparate-associated protein 1
(gluta protein.
Length = 371
Score = 30.3 bits (65), Expect = 5.8
Identities = 16/51 (31%), Positives = 28/51 (54%), Gaps = 2/51 (3%)
Frame = +2
Query: 302 QQIWEGVSSVSVHFVESIFFSL-GIFVAKHPWQVIFGTLLFVTVS-CIGLI 448
+ +W S +V F+ I S G F KHPW ++ ++L ++S +G+I
Sbjct: 195 ENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVALSVLTASLSYMVGMI 245
>AB097026-1|BAC77379.1| 371|Homo sapiens putative MAPK activating
protein protein.
Length = 371
Score = 30.3 bits (65), Expect = 5.8
Identities = 16/51 (31%), Positives = 28/51 (54%), Gaps = 2/51 (3%)
Frame = +2
Query: 302 QQIWEGVSSVSVHFVESIFFSL-GIFVAKHPWQVIFGTLLFVTVS-CIGLI 448
+ +W S +V F+ I S G F KHPW ++ ++L ++S +G+I
Sbjct: 195 ENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVALSVLTASLSYMVGMI 245
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 93,315,019
Number of Sequences: 237096
Number of extensions: 2086624
Number of successful extensions: 3524
Number of sequences better than 10.0: 25
Number of HSP's better than 10.0 without gapping: 3435
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3524
length of database: 76,859,062
effective HSP length: 87
effective length of database: 56,231,710
effective search space used: 6804036910
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -