Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fner12f10r
(760 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U17857-1|AAA85687.1| 752|Homo sapiens hMLH1 protein. 169 7e-42
AK222810-1|BAD96530.1| 756|Homo sapiens MutL protein homolog 1 ... 167 5e-41
U40978-1|AAA82079.1| 756|Homo sapiens DNA mismatch repair prote... 166 7e-41
U07418-1|AAA17374.1| 756|Homo sapiens hmlh1 protein. 166 7e-41
U07343-1|AAC50285.1| 756|Homo sapiens DNA mismatch repair prote... 166 7e-41
BC006850-1|AAH06850.1| 756|Homo sapiens mutL homolog 1, colon c... 166 7e-41
AY517558-1|AAT44531.1| 755|Homo sapiens hypothetical rhabdomyos... 166 7e-41
AY217549-1|AAO22994.1| 756|Homo sapiens mutL homolog 1, colon c... 166 7e-41
AB209848-1|BAD93085.1| 552|Homo sapiens MutL protein homolog 1 ... 80 7e-15
DQ648892-1|ABG49487.1| 114|Homo sapiens MLH1-Ex(15-18) isoform ... 37 0.091
AY344475-1|AAQ23474.1| 38|Homo sapiens mutant mismatch repair ... 37 0.091
>U17857-1|AAA85687.1| 752|Homo sapiens hMLH1 protein.
Length = 752
Score = 169 bits (412), Expect = 7e-42
Identities = 92/244 (37%), Positives = 136/244 (55%), Gaps = 9/244 (3%)
Frame = -2
Query: 705 QIEVENNCNSNLREILANLIFIACIDCHKSLIQHSTKLYLCDXXXXXXXXXXXXXLYDFQ 526
Q E+ + LRE+L N F+ C++ +L QH TKLYL + +YDF
Sbjct: 510 QEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFA 569
Query: 525 NFGFIKLSNPLPLEELFVLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFS 346
NFG ++LS P PL +L +L L+ + S E G +A+++ + L K ML +YFS
Sbjct: 570 NFGVLRLSEPAPLFDLAMLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFS 627
Query: 345 LEVNGEGEXXXXXXXLDGHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQP 166
LE++ EG +D + P + LP +++RL TEVNWD EKECFE+ ++ A FY+
Sbjct: 628 LEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIR 687
Query: 165 NPDPNVESVSSEHRRQ---------EHVIFPAIRKYFLPPSSFISNGAILQIASLNDLYK 13
+ ES S + + EH+++ A+R + LPP F +G ILQ+A+L DLYK
Sbjct: 688 KQYISEESTLSGQQSEVPGSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYK 747
Query: 12 VFER 1
VFER
Sbjct: 748 VFER 751
>AK222810-1|BAD96530.1| 756|Homo sapiens MutL protein homolog 1
variant protein.
Length = 756
Score = 167 bits (405), Expect = 5e-41
Identities = 92/248 (37%), Positives = 136/248 (54%), Gaps = 13/248 (5%)
Frame = -2
Query: 705 QIEVENNCNSNLREILANLIFIACIDCHKSLIQHSTKLYLCDXXXXXXXXXXXXXLYDFQ 526
Q E+ + LRE+L N F+ C++ +L QH TKLYL + +YDF
Sbjct: 510 QEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNATKLSEELFYQILIYDFA 569
Query: 525 NFGFIKLSNPLPLEELFVLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFS 346
NFG ++LS P PL +L +L L+ + S E G +A+++ + L K ML +YFS
Sbjct: 570 NFGVLRLSEPAPLFDLAMLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFS 627
Query: 345 LEVNGEGEXXXXXXXLDGHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQP 166
LE++ EG +D + P + LP +++RL TEVNWD EKECFE+ ++ A FY+
Sbjct: 628 LEIDEEGNLTGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIR 687
Query: 165 NPDPNVESVSSEHRRQ-------------EHVIFPAIRKYFLPPSSFISNGAILQIASLN 25
+ ES S + + EH+++ A+R + LPP F +G ILQ+A+L
Sbjct: 688 KQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLP 747
Query: 24 DLYKVFER 1
DLYKVFER
Sbjct: 748 DLYKVFER 755
>U40978-1|AAA82079.1| 756|Homo sapiens DNA mismatch repair protein
homolog protein.
Length = 756
Score = 166 bits (404), Expect = 7e-41
Identities = 92/248 (37%), Positives = 136/248 (54%), Gaps = 13/248 (5%)
Frame = -2
Query: 705 QIEVENNCNSNLREILANLIFIACIDCHKSLIQHSTKLYLCDXXXXXXXXXXXXXLYDFQ 526
Q E+ + LRE+L N F+ C++ +L QH TKLYL + +YDF
Sbjct: 510 QEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFA 569
Query: 525 NFGFIKLSNPLPLEELFVLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFS 346
NFG ++LS P PL +L +L L+ + S E G +A+++ + L K ML +YFS
Sbjct: 570 NFGVLRLSEPAPLFDLAMLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFS 627
Query: 345 LEVNGEGEXXXXXXXLDGHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQP 166
LE++ EG +D + P + LP +++RL TEVNWD EKECFE+ ++ A FY+
Sbjct: 628 LEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIR 687
Query: 165 NPDPNVESVSSEHRRQ-------------EHVIFPAIRKYFLPPSSFISNGAILQIASLN 25
+ ES S + + EH+++ A+R + LPP F +G ILQ+A+L
Sbjct: 688 KQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLP 747
Query: 24 DLYKVFER 1
DLYKVFER
Sbjct: 748 DLYKVFER 755
>U07418-1|AAA17374.1| 756|Homo sapiens hmlh1 protein.
Length = 756
Score = 166 bits (404), Expect = 7e-41
Identities = 92/248 (37%), Positives = 136/248 (54%), Gaps = 13/248 (5%)
Frame = -2
Query: 705 QIEVENNCNSNLREILANLIFIACIDCHKSLIQHSTKLYLCDXXXXXXXXXXXXXLYDFQ 526
Q E+ + LRE+L N F+ C++ +L QH TKLYL + +YDF
Sbjct: 510 QEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFA 569
Query: 525 NFGFIKLSNPLPLEELFVLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFS 346
NFG ++LS P PL +L +L L+ + S E G +A+++ + L K ML +YFS
Sbjct: 570 NFGVLRLSEPAPLFDLAMLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFS 627
Query: 345 LEVNGEGEXXXXXXXLDGHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQP 166
LE++ EG +D + P + LP +++RL TEVNWD EKECFE+ ++ A FY+
Sbjct: 628 LEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIR 687
Query: 165 NPDPNVESVSSEHRRQ-------------EHVIFPAIRKYFLPPSSFISNGAILQIASLN 25
+ ES S + + EH+++ A+R + LPP F +G ILQ+A+L
Sbjct: 688 KQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLP 747
Query: 24 DLYKVFER 1
DLYKVFER
Sbjct: 748 DLYKVFER 755
>U07343-1|AAC50285.1| 756|Homo sapiens DNA mismatch repair protein
homolog protein.
Length = 756
Score = 166 bits (404), Expect = 7e-41
Identities = 92/248 (37%), Positives = 136/248 (54%), Gaps = 13/248 (5%)
Frame = -2
Query: 705 QIEVENNCNSNLREILANLIFIACIDCHKSLIQHSTKLYLCDXXXXXXXXXXXXXLYDFQ 526
Q E+ + LRE+L N F+ C++ +L QH TKLYL + +YDF
Sbjct: 510 QEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFA 569
Query: 525 NFGFIKLSNPLPLEELFVLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFS 346
NFG ++LS P PL +L +L L+ + S E G +A+++ + L K ML +YFS
Sbjct: 570 NFGVLRLSEPAPLFDLAMLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFS 627
Query: 345 LEVNGEGEXXXXXXXLDGHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQP 166
LE++ EG +D + P + LP +++RL TEVNWD EKECFE+ ++ A FY+
Sbjct: 628 LEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIR 687
Query: 165 NPDPNVESVSSEHRRQ-------------EHVIFPAIRKYFLPPSSFISNGAILQIASLN 25
+ ES S + + EH+++ A+R + LPP F +G ILQ+A+L
Sbjct: 688 KQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLP 747
Query: 24 DLYKVFER 1
DLYKVFER
Sbjct: 748 DLYKVFER 755
>BC006850-1|AAH06850.1| 756|Homo sapiens mutL homolog 1, colon
cancer, nonpolyposis type 2 (E. coli) protein.
Length = 756
Score = 166 bits (404), Expect = 7e-41
Identities = 92/248 (37%), Positives = 136/248 (54%), Gaps = 13/248 (5%)
Frame = -2
Query: 705 QIEVENNCNSNLREILANLIFIACIDCHKSLIQHSTKLYLCDXXXXXXXXXXXXXLYDFQ 526
Q E+ + LRE+L N F+ C++ +L QH TKLYL + +YDF
Sbjct: 510 QEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFA 569
Query: 525 NFGFIKLSNPLPLEELFVLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFS 346
NFG ++LS P PL +L +L L+ + S E G +A+++ + L K ML +YFS
Sbjct: 570 NFGVLRLSEPAPLFDLAMLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFS 627
Query: 345 LEVNGEGEXXXXXXXLDGHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQP 166
LE++ EG +D + P + LP +++RL TEVNWD EKECFE+ ++ A FY+
Sbjct: 628 LEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIR 687
Query: 165 NPDPNVESVSSEHRRQ-------------EHVIFPAIRKYFLPPSSFISNGAILQIASLN 25
+ ES S + + EH+++ A+R + LPP F +G ILQ+A+L
Sbjct: 688 KQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLP 747
Query: 24 DLYKVFER 1
DLYKVFER
Sbjct: 748 DLYKVFER 755
>AY517558-1|AAT44531.1| 755|Homo sapiens hypothetical
rhabdomyosarcoma antigen MU-RMS-40.5 protein.
Length = 755
Score = 166 bits (404), Expect = 7e-41
Identities = 92/248 (37%), Positives = 136/248 (54%), Gaps = 13/248 (5%)
Frame = -2
Query: 705 QIEVENNCNSNLREILANLIFIACIDCHKSLIQHSTKLYLCDXXXXXXXXXXXXXLYDFQ 526
Q E+ + LRE+L N F+ C++ +L QH TKLYL + +YDF
Sbjct: 509 QEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFA 568
Query: 525 NFGFIKLSNPLPLEELFVLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFS 346
NFG ++LS P PL +L +L L+ + S E G +A+++ + L K ML +YFS
Sbjct: 569 NFGVLRLSEPAPLFDLAMLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFS 626
Query: 345 LEVNGEGEXXXXXXXLDGHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQP 166
LE++ EG +D + P + LP +++RL TEVNWD EKECFE+ ++ A FY+
Sbjct: 627 LEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIR 686
Query: 165 NPDPNVESVSSEHRRQ-------------EHVIFPAIRKYFLPPSSFISNGAILQIASLN 25
+ ES S + + EH+++ A+R + LPP F +G ILQ+A+L
Sbjct: 687 KQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLP 746
Query: 24 DLYKVFER 1
DLYKVFER
Sbjct: 747 DLYKVFER 754
>AY217549-1|AAO22994.1| 756|Homo sapiens mutL homolog 1, colon
cancer, nonpolyposis type 2 (E. coli) protein.
Length = 756
Score = 166 bits (404), Expect = 7e-41
Identities = 92/248 (37%), Positives = 136/248 (54%), Gaps = 13/248 (5%)
Frame = -2
Query: 705 QIEVENNCNSNLREILANLIFIACIDCHKSLIQHSTKLYLCDXXXXXXXXXXXXXLYDFQ 526
Q E+ + LRE+L N F+ C++ +L QH TKLYL + +YDF
Sbjct: 510 QEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFA 569
Query: 525 NFGFIKLSNPLPLEELFVLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFS 346
NFG ++LS P PL +L +L L+ + S E G +A+++ + L K ML +YFS
Sbjct: 570 NFGVLRLSEPAPLFDLAMLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFS 627
Query: 345 LEVNGEGEXXXXXXXLDGHAPFVGALPTYLVRLVTEVNWDSEKECFETFCRQTAKFYAQP 166
LE++ EG +D + P + LP +++RL TEVNWD EKECFE+ ++ A FY+
Sbjct: 628 LEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIR 687
Query: 165 NPDPNVESVSSEHRRQ-------------EHVIFPAIRKYFLPPSSFISNGAILQIASLN 25
+ ES S + + EH+++ A+R + LPP F +G ILQ+A+L
Sbjct: 688 KQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLP 747
Query: 24 DLYKVFER 1
DLYKVFER
Sbjct: 748 DLYKVFER 755
>AB209848-1|BAD93085.1| 552|Homo sapiens MutL protein homolog 1
variant protein.
Length = 552
Score = 80.2 bits (189), Expect = 7e-15
Identities = 44/124 (35%), Positives = 67/124 (54%)
Frame = -2
Query: 705 QIEVENNCNSNLREILANLIFIACIDCHKSLIQHSTKLYLCDXXXXXXXXXXXXXLYDFQ 526
Q E+ + LRE+L N F+ C++ +L QH TKLYL + +YDF
Sbjct: 375 QEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFA 434
Query: 525 NFGFIKLSNPLPLEELFVLGLNGSTQNSEQDSELGDTGEMAQHMTQLLLSKRAMLYEYFS 346
NFG ++LS P PL +L +L L+ + S E G +A+++ + L K ML +YFS
Sbjct: 435 NFGVLRLSEPAPLFDLAMLALD--SPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFS 492
Query: 345 LEVN 334
LE++
Sbjct: 493 LEID 496
Score = 54.4 bits (125), Expect = 4e-07
Identities = 22/39 (56%), Positives = 30/39 (76%)
Frame = -2
Query: 117 EHVIFPAIRKYFLPPSSFISNGAILQIASLNDLYKVFER 1
EH+++ A+R + LPP F +G ILQ+A+L DLYKVFER
Sbjct: 513 EHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFER 551
>DQ648892-1|ABG49487.1| 114|Homo sapiens MLH1-Ex(15-18) isoform
protein.
Length = 114
Score = 36.7 bits (81), Expect = 0.091
Identities = 17/40 (42%), Positives = 24/40 (60%)
Frame = -2
Query: 705 QIEVENNCNSNLREILANLIFIACIDCHKSLIQHSTKLYL 586
Q E+ + LRE+L N F+ C++ +L QH TKLYL
Sbjct: 51 QEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYL 90
>AY344475-1|AAQ23474.1| 38|Homo sapiens mutant mismatch repair
protein protein.
Length = 38
Score = 36.7 bits (81), Expect = 0.091
Identities = 13/22 (59%), Positives = 17/22 (77%)
Frame = -2
Query: 237 VNWDSEKECFETFCRQTAKFYA 172
VNWD EKECFE+ ++ A FY+
Sbjct: 1 VNWDEEKECFESLSKEGAMFYS 22
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 107,326,466
Number of Sequences: 237096
Number of extensions: 2238520
Number of successful extensions: 7574
Number of sequences better than 10.0: 11
Number of HSP's better than 10.0 without gapping: 7448
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7557
length of database: 76,859,062
effective HSP length: 88
effective length of database: 55,994,614
effective search space used: 9183116696
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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