Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fner12d21f
(609 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC007993-1|AAH07993.1| 274|Homo sapiens pyrroline-5-carboxylate... 79 1e-14
AK222685-1|BAD96405.1| 276|Homo sapiens Pyrroline-5-carboxylate... 79 1e-14
AK023914-1|BAB14721.1| 274|Homo sapiens protein ( Homo sapiens ... 79 1e-14
M77836-1|AAA36407.1| 319|Homo sapiens pyrroline-5-carboxylate r... 77 5e-14
CR541769-1|CAG46568.1| 319|Homo sapiens PYCR1 protein. 77 5e-14
BC071842-1|AAH71842.1| 319|Homo sapiens pyrroline-5-carboxylate... 77 5e-14
BC001504-1|AAH01504.1| 319|Homo sapiens pyrroline-5-carboxylate... 77 5e-14
AF218000-1|AAG17242.1| 272|Homo sapiens unknown protein. 77 5e-14
BC020553-1|AAH20553.1| 320|Homo sapiens pyrroline-5-carboxylate... 73 6e-13
BC014868-1|AAH14868.1| 320|Homo sapiens pyrroline-5-carboxylate... 73 6e-13
AL117348-6|CAI21802.1| 320|Homo sapiens pyrroline-5-carboxylate... 73 6e-13
AF087859-1|AAP97169.1| 320|Homo sapiens pyrroline 5-carboxylate... 68 2e-11
AL833857-1|CAD38716.1| 244|Homo sapiens hypothetical protein pr... 54 5e-07
AL117348-7|CAI21803.1| 66|Homo sapiens pyrroline-5-carboxylate... 44 6e-04
AL117348-5|CAI21801.1| 214|Homo sapiens pyrroline-5-carboxylate... 43 0.001
AL117348-4|CAI21800.1| 185|Homo sapiens pyrroline-5-carboxylate... 43 0.001
AF151351-1|AAD34611.1| 319|Homo sapiens pyrroline 5-carboxylate... 42 0.001
>BC007993-1|AAH07993.1| 274|Homo sapiens pyrroline-5-carboxylate
reductase-like protein.
Length = 274
Score = 79.0 bits (186), Expect = 1e-14
Identities = 45/135 (33%), Positives = 70/135 (51%)
Frame = +3
Query: 198 KIGFIGGGRLAFALANGFISAGLAKPDEITASCHPSDVASAKAFQGLGATALFENXXXXX 377
++GF+G GR+A A+A G I AG + I AS P+D + FQ LG N
Sbjct: 10 RVGFVGAGRMAGAIAQGLIRAGKVEAQHILASA-PTD-RNLCHFQALGCRTTHSNQEVLQ 67
Query: 378 XXXXXXXXXXXXXXXPALKEIKNLPSAKNKLFISVAMGITIATVESNLPSEARVIRVMPN 557
L E+ + + ++ + +SVA G++++T+E LP RV+RV+PN
Sbjct: 68 SCLLVIFATKPHVLPAVLAEVAPVVTTEH-ILVSVAAGVSLSTLEELLPPNTRVLRVLPN 126
Query: 558 TPALVKEGAAAFSRG 602
P +V+EGA +RG
Sbjct: 127 LPCVVQEGAIVMARG 141
>AK222685-1|BAD96405.1| 276|Homo sapiens Pyrroline-5-carboxylate
reductase-like variant protein.
Length = 276
Score = 79.0 bits (186), Expect = 1e-14
Identities = 45/135 (33%), Positives = 70/135 (51%)
Frame = +3
Query: 198 KIGFIGGGRLAFALANGFISAGLAKPDEITASCHPSDVASAKAFQGLGATALFENXXXXX 377
++GF+G GR+A A+A G I AG + I AS P+D + FQ LG N
Sbjct: 22 RVGFVGAGRMAGAIAQGLIRAGKVEAQHILASA-PTD-RNLCHFQALGCRTTHSNQEVLQ 79
Query: 378 XXXXXXXXXXXXXXXPALKEIKNLPSAKNKLFISVAMGITIATVESNLPSEARVIRVMPN 557
L E+ + + ++ + +SVA G++++T+E LP RV+RV+PN
Sbjct: 80 SCLLVIFATKPHVLPAVLAEVAPVVTTEH-ILVSVAAGVSLSTLEELLPPNTRVLRVLPN 138
Query: 558 TPALVKEGAAAFSRG 602
P +V+EGA +RG
Sbjct: 139 LPCVVQEGAIVMARG 153
>AK023914-1|BAB14721.1| 274|Homo sapiens protein ( Homo sapiens
cDNA FLJ13852 fis, clone THYRO1000934, weakly similar to
PYRROLINE-5-CARBOXYLATE REDUCTASE (EC 1.5.1.2). ).
Length = 274
Score = 79.0 bits (186), Expect = 1e-14
Identities = 45/135 (33%), Positives = 70/135 (51%)
Frame = +3
Query: 198 KIGFIGGGRLAFALANGFISAGLAKPDEITASCHPSDVASAKAFQGLGATALFENXXXXX 377
++GF+G GR+A A+A G I AG + I AS P+D + FQ LG N
Sbjct: 10 RVGFVGAGRMAGAIAQGLIRAGKVEAQHILASA-PTD-RNLCHFQALGCRTTHSNQEVLQ 67
Query: 378 XXXXXXXXXXXXXXXPALKEIKNLPSAKNKLFISVAMGITIATVESNLPSEARVIRVMPN 557
L E+ + + ++ + +SVA G++++T+E LP RV+RV+PN
Sbjct: 68 SCLLVIFATKPHVLPAVLAEVAPVVTTEH-ILVSVAAGVSLSTLEELLPPNTRVLRVLPN 126
Query: 558 TPALVKEGAAAFSRG 602
P +V+EGA +RG
Sbjct: 127 LPCVVQEGAIVMARG 141
>M77836-1|AAA36407.1| 319|Homo sapiens pyrroline-5-carboxylate
reductase protein.
Length = 319
Score = 77.0 bits (181), Expect = 5e-14
Identities = 48/140 (34%), Positives = 68/140 (48%), Gaps = 3/140 (2%)
Frame = +3
Query: 195 MKIGFIGGGRLAFALANGFISAGLAKPDEITASCHPSDVASAKAFQGLGATALFENXXXX 374
M +GFIG G+LAFALA GF +AG+ +I AS D+A+ A + +G N
Sbjct: 1 MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETV 60
Query: 375 XXXXXXXXXXXXXXXXPALKEIKNLPSAKNKLFISVAMGITIATVESNLPS---EARVIR 545
L EI + +S A G+TI+++E L + RVIR
Sbjct: 61 QHSDVLFLAVKPHIIPFILDEI-GADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIR 119
Query: 546 VMPNTPALVKEGAAAFSRGT 605
M NTP +V+EGA ++ GT
Sbjct: 120 CMTNTPVVVREGATVYATGT 139
>CR541769-1|CAG46568.1| 319|Homo sapiens PYCR1 protein.
Length = 319
Score = 77.0 bits (181), Expect = 5e-14
Identities = 48/140 (34%), Positives = 68/140 (48%), Gaps = 3/140 (2%)
Frame = +3
Query: 195 MKIGFIGGGRLAFALANGFISAGLAKPDEITASCHPSDVASAKAFQGLGATALFENXXXX 374
M +GFIG G+LAFALA GF +AG+ +I AS D+A+ A + +G N
Sbjct: 1 MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETV 60
Query: 375 XXXXXXXXXXXXXXXXPALKEIKNLPSAKNKLFISVAMGITIATVESNLPS---EARVIR 545
L EI + +S A G+TI+++E L + RVIR
Sbjct: 61 QHSDVLFLAVKPHIIPFILDEI-GADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIR 119
Query: 546 VMPNTPALVKEGAAAFSRGT 605
M NTP +V+EGA ++ GT
Sbjct: 120 CMTNTPVVVREGATVYATGT 139
>BC071842-1|AAH71842.1| 319|Homo sapiens pyrroline-5-carboxylate
reductase 1 protein.
Length = 319
Score = 77.0 bits (181), Expect = 5e-14
Identities = 48/140 (34%), Positives = 68/140 (48%), Gaps = 3/140 (2%)
Frame = +3
Query: 195 MKIGFIGGGRLAFALANGFISAGLAKPDEITASCHPSDVASAKAFQGLGATALFENXXXX 374
M +GFIG G+LAFALA GF +AG+ +I AS D+A+ A + +G N
Sbjct: 1 MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETV 60
Query: 375 XXXXXXXXXXXXXXXXPALKEIKNLPSAKNKLFISVAMGITIATVESNLPS---EARVIR 545
L EI + +S A G+TI+++E L + RVIR
Sbjct: 61 QHSDVLFLAVKPHIIPFILDEI-GADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIR 119
Query: 546 VMPNTPALVKEGAAAFSRGT 605
M NTP +V+EGA ++ GT
Sbjct: 120 CMTNTPVVVREGATVYATGT 139
>BC001504-1|AAH01504.1| 319|Homo sapiens pyrroline-5-carboxylate
reductase 1 protein.
Length = 319
Score = 77.0 bits (181), Expect = 5e-14
Identities = 48/140 (34%), Positives = 68/140 (48%), Gaps = 3/140 (2%)
Frame = +3
Query: 195 MKIGFIGGGRLAFALANGFISAGLAKPDEITASCHPSDVASAKAFQGLGATALFENXXXX 374
M +GFIG G+LAFALA GF +AG+ +I AS D+A+ A + +G N
Sbjct: 1 MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETV 60
Query: 375 XXXXXXXXXXXXXXXXPALKEIKNLPSAKNKLFISVAMGITIATVESNLPS---EARVIR 545
L EI + +S A G+TI+++E L + RVIR
Sbjct: 61 QHSDVLFLAVKPHIIPFILDEI-GADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIR 119
Query: 546 VMPNTPALVKEGAAAFSRGT 605
M NTP +V+EGA ++ GT
Sbjct: 120 CMTNTPVVVREGATVYATGT 139
>AF218000-1|AAG17242.1| 272|Homo sapiens unknown protein.
Length = 272
Score = 77.0 bits (181), Expect = 5e-14
Identities = 48/140 (34%), Positives = 68/140 (48%), Gaps = 3/140 (2%)
Frame = +3
Query: 195 MKIGFIGGGRLAFALANGFISAGLAKPDEITASCHPSDVASAKAFQGLGATALFENXXXX 374
M +GFIG G+LAFALA GF +AG+ +I AS D+A+ A + +G N
Sbjct: 1 MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETV 60
Query: 375 XXXXXXXXXXXXXXXXPALKEIKNLPSAKNKLFISVAMGITIATVESNLPS---EARVIR 545
L EI + +S A G+TI+++E L + RVIR
Sbjct: 61 QHSDVLFLAVKPHIIPFILDEI-GADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIR 119
Query: 546 VMPNTPALVKEGAAAFSRGT 605
M NTP +V+EGA ++ GT
Sbjct: 120 CMTNTPVVVREGATVYATGT 139
>BC020553-1|AAH20553.1| 320|Homo sapiens pyrroline-5-carboxylate
reductase family, member 2 protein.
Length = 320
Score = 73.3 bits (172), Expect = 6e-13
Identities = 46/140 (32%), Positives = 70/140 (50%), Gaps = 3/140 (2%)
Frame = +3
Query: 195 MKIGFIGGGRLAFALANGFISAGLAKPDEITASCHPSDVASAKAFQGLGATALFENXXXX 374
M +GFIG G+LA+ALA GF +AG+ +I AS ++ + A + +G N
Sbjct: 1 MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV 60
Query: 375 XXXXXXXXXXXXXXXXPALKEIKNLPSAKNKLFISVAMGITIATVESNLPS---EARVIR 545
L EI A++ + +S A G+TI++VE L + +VIR
Sbjct: 61 KHSDVLFLAVKPHIIPFILDEIGADVQARH-IVVSCAAGVTISSVEKKLMAFQPAPKVIR 119
Query: 546 VMPNTPALVKEGAAAFSRGT 605
M NTP +V+EGA ++ GT
Sbjct: 120 CMTNTPVVVQEGATVYATGT 139
>BC014868-1|AAH14868.1| 320|Homo sapiens pyrroline-5-carboxylate
reductase family, member 2 protein.
Length = 320
Score = 73.3 bits (172), Expect = 6e-13
Identities = 46/140 (32%), Positives = 70/140 (50%), Gaps = 3/140 (2%)
Frame = +3
Query: 195 MKIGFIGGGRLAFALANGFISAGLAKPDEITASCHPSDVASAKAFQGLGATALFENXXXX 374
M +GFIG G+LA+ALA GF +AG+ +I AS ++ + A + +G N
Sbjct: 1 MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV 60
Query: 375 XXXXXXXXXXXXXXXXPALKEIKNLPSAKNKLFISVAMGITIATVESNLPS---EARVIR 545
L EI A++ + +S A G+TI++VE L + +VIR
Sbjct: 61 KHSDVLFLAVKPHIIPFILDEIGADVQARH-IVVSCAAGVTISSVEKKLMAFQPAPKVIR 119
Query: 546 VMPNTPALVKEGAAAFSRGT 605
M NTP +V+EGA ++ GT
Sbjct: 120 CMTNTPVVVQEGATVYATGT 139
>AL117348-6|CAI21802.1| 320|Homo sapiens pyrroline-5-carboxylate
reductase family, member 2 protein.
Length = 320
Score = 73.3 bits (172), Expect = 6e-13
Identities = 46/140 (32%), Positives = 70/140 (50%), Gaps = 3/140 (2%)
Frame = +3
Query: 195 MKIGFIGGGRLAFALANGFISAGLAKPDEITASCHPSDVASAKAFQGLGATALFENXXXX 374
M +GFIG G+LA+ALA GF +AG+ +I AS ++ + A + +G N
Sbjct: 1 MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV 60
Query: 375 XXXXXXXXXXXXXXXXPALKEIKNLPSAKNKLFISVAMGITIATVESNLPS---EARVIR 545
L EI A++ + +S A G+TI++VE L + +VIR
Sbjct: 61 KHSDVLFLAVKPHIIPFILDEIGADVQARH-IVVSCAAGVTISSVEKKLMAFQPAPKVIR 119
Query: 546 VMPNTPALVKEGAAAFSRGT 605
M NTP +V+EGA ++ GT
Sbjct: 120 CMTNTPVVVQEGATVYATGT 139
>AF087859-1|AAP97169.1| 320|Homo sapiens pyrroline 5-carboxylate
reductase protein.
Length = 320
Score = 68.1 bits (159), Expect = 2e-11
Identities = 45/140 (32%), Positives = 67/140 (47%), Gaps = 3/140 (2%)
Frame = +3
Query: 195 MKIGFIGGGRLAFALANGFISAGLAKPDEITASCHPSDVASAKAFQGLGATALFENXXXX 374
M +GFIG G+LA ALA GF +A +I AS ++ + A + +G N
Sbjct: 1 MSVGFIGAGQLANALARGFTAAAFLSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV 60
Query: 375 XXXXXXXXXXXXXXXXPALKEIKNLPSAKNKLFISVAMGITIATVESNLPS---EARVIR 545
L EI A++ + +S A G+TI++VE L + +VIR
Sbjct: 61 KHSDVLFLAVKHIIIPFILDEIGADVQARH-IVVSCAAGVTISSVEKKLMAFQPAPKVIR 119
Query: 546 VMPNTPALVKEGAAAFSRGT 605
M NTP +V+EGA ++ GT
Sbjct: 120 CMTNTPVVVQEGATVYATGT 139
>AL833857-1|CAD38716.1| 244|Homo sapiens hypothetical protein
protein.
Length = 244
Score = 53.6 bits (123), Expect = 5e-07
Identities = 34/114 (29%), Positives = 54/114 (47%)
Frame = +3
Query: 261 GLAKPDEITASCHPSDVASAKAFQGLGATALFENXXXXXXXXXXXXXXXXXXXXPALKEI 440
G + I AS P+D + FQ LG N L E+
Sbjct: 1 GKVEAQHILASA-PTD-RNLCHFQALGCRTTHSNQEVLQSCLLVIFATKPHVLPAVLAEV 58
Query: 441 KNLPSAKNKLFISVAMGITIATVESNLPSEARVIRVMPNTPALVKEGAAAFSRG 602
+ + ++ + +SVA G++++T+E LP RV+RV+PN P +V+EGA +RG
Sbjct: 59 APVVTTEH-ILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARG 111
>AL117348-7|CAI21803.1| 66|Homo sapiens pyrroline-5-carboxylate
reductase family, member 2 protein.
Length = 66
Score = 43.6 bits (98), Expect = 6e-04
Identities = 21/50 (42%), Positives = 31/50 (62%)
Frame = +3
Query: 195 MKIGFIGGGRLAFALANGFISAGLAKPDEITASCHPSDVASAKAFQGLGA 344
M +GFIG G+LA+ALA GF +AG+ +I AS ++ + A + GA
Sbjct: 1 MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRVGGA 50
>AL117348-5|CAI21801.1| 214|Homo sapiens pyrroline-5-carboxylate
reductase family, member 2 protein.
Length = 214
Score = 42.7 bits (96), Expect = 0.001
Identities = 21/49 (42%), Positives = 32/49 (65%), Gaps = 3/49 (6%)
Frame = +3
Query: 468 LFISVAMGITIATVESNLPS---EARVIRVMPNTPALVKEGAAAFSRGT 605
+ +S A G+TI++VE L + +VIR M NTP +V+EGA ++ GT
Sbjct: 44 IVVSCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVVQEGATVYATGT 92
>AL117348-4|CAI21800.1| 185|Homo sapiens pyrroline-5-carboxylate
reductase family, member 2 protein.
Length = 185
Score = 42.7 bits (96), Expect = 0.001
Identities = 21/49 (42%), Positives = 32/49 (65%), Gaps = 3/49 (6%)
Frame = +3
Query: 468 LFISVAMGITIATVESNLPS---EARVIRVMPNTPALVKEGAAAFSRGT 605
+ +S A G+TI++VE L + +VIR M NTP +V+EGA ++ GT
Sbjct: 44 IVVSCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVVQEGATVYATGT 92
>AF151351-1|AAD34611.1| 319|Homo sapiens pyrroline 5-carboxylate
reductase isoform protein.
Length = 319
Score = 42.3 bits (95), Expect = 0.001
Identities = 21/49 (42%), Positives = 31/49 (63%), Gaps = 3/49 (6%)
Frame = +3
Query: 468 LFISVAMGITIATVESNLPS---EARVIRVMPNTPALVKEGAAAFSRGT 605
+ +S A G+TI++VE L +VIR M NTP +V+EGA ++ GT
Sbjct: 90 IVVSCAAGVTISSVEKKLMEFQPAPKVIRCMTNTPVVVQEGATVYATGT 138
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 80,333,145
Number of Sequences: 237096
Number of extensions: 1698268
Number of successful extensions: 2649
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 2591
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2637
length of database: 76,859,062
effective HSP length: 87
effective length of database: 56,231,710
effective search space used: 6466646650
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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