Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fner10p18f
(620 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q17DR1 Cluster: Cystathionine beta-lyase; n=6; Coelomat... 221 1e-56
UniRef50_P32929 Cluster: Cystathionine gamma-lyase; n=38; cellul... 190 2e-47
UniRef50_UPI0000F2BB70 Cluster: PREDICTED: similar to Chain A, C... 189 5e-47
UniRef50_Q8VCN5 Cluster: Cystathionine gamma-lyase; n=39; Eukary... 180 2e-44
UniRef50_Q23CV0 Cluster: Cystathionine beta-lyase; n=3; Oligohym... 166 4e-40
UniRef50_P24601 Cluster: Probable cystathionine gamma-synthase (... 164 2e-39
UniRef50_Q129P6 Cluster: Cystathionine gamma-synthase; n=11; cel... 161 9e-39
UniRef50_P56069 Cluster: Cystathionine gamma-synthase (EC 2.5.1.... 140 2e-32
UniRef50_Q97M10 Cluster: Cystathionine gamma-synthase; n=15; Bac... 139 4e-32
UniRef50_Q5L1M8 Cluster: Cystathionine beta-lyase; n=42; Bacteri... 138 1e-31
UniRef50_Q6N7A1 Cluster: Cystathionine gamma-lyase; n=52; cellul... 136 4e-31
UniRef50_Q1INQ0 Cluster: Cystathionine gamma-synthase; n=2; Bact... 135 7e-31
UniRef50_A6LPZ9 Cluster: Cystathionine gamma-synthase; n=4; Bact... 133 3e-30
UniRef50_Q8KEI8 Cluster: Trans-sulfuration enzyme family protein... 133 4e-30
UniRef50_Q74EL7 Cluster: Cystathionine beta-lyase; n=5; Bacteria... 133 4e-30
UniRef50_Q4A0K3 Cluster: Cystathionine gamma-synthase; n=4; Bact... 131 1e-29
UniRef50_Q9EWF9 Cluster: Cystathionine gamma-synthase; n=6; Bact... 130 2e-29
UniRef50_Q1IQD6 Cluster: Cystathionine gamma-synthase; n=2; Acid... 130 3e-29
UniRef50_Q838Z2 Cluster: Cystathionine beta-lyase; n=8; Bacteria... 129 5e-29
UniRef50_A7HF96 Cluster: Cystathionine gamma-synthase; n=7; Bact... 127 2e-28
UniRef50_Q49UL2 Cluster: Cystathionine beta-lyase cystathionine ... 127 2e-28
UniRef50_Q2IEA5 Cluster: Cystathionine gamma-synthase; n=1; Anae... 126 6e-28
UniRef50_P46807 Cluster: Cystathionine gamma-synthase (EC 2.5.1.... 123 4e-27
UniRef50_Q38DH3 Cluster: Cystathione gamma lyase, putative; n=7;... 121 1e-26
UniRef50_P53780 Cluster: Cystathionine beta-lyase, chloroplast p... 120 3e-26
UniRef50_A6X770 Cluster: Cystathionine gamma-synthase; n=1; Ochr... 120 4e-26
UniRef50_A3HJ37 Cluster: Cystathionine gamma-lyase; n=7; Gammapr... 114 1e-24
UniRef50_A5GJ98 Cluster: MetC/metB Cystathionine beta-lyase/cyst... 113 2e-24
UniRef50_Q8XNZ9 Cluster: Cystathionine gamma-synthase; n=7; Bact... 113 3e-24
UniRef50_Q8KNG3 Cluster: CalE6; n=2; Micromonosporaceae|Rep: Cal... 112 6e-24
UniRef50_A5E0C2 Cluster: Cystathionine gamma-lyase; n=6; cellula... 112 6e-24
UniRef50_Q5MQ31 Cluster: L-methionine-gamma-lyase; n=3; Micrococ... 110 2e-23
UniRef50_Q1IQ68 Cluster: Cystathionine gamma-synthase; n=1; Acid... 108 9e-23
UniRef50_Q4QFT8 Cluster: Cystathionine beta-lyase-like protein; ... 108 9e-23
UniRef50_Q8R9N2 Cluster: Cystathionine beta-lyases/cystathionine... 107 2e-22
UniRef50_Q8TMW7 Cluster: Methionine gamma-lyase; n=3; Methanosar... 107 2e-22
UniRef50_Q9KCE4 Cluster: Cystathionine gamma-synthase (O-succiny... 107 3e-22
UniRef50_Q0LLX7 Cluster: Cystathionine gamma-synthase; n=3; Bact... 107 3e-22
UniRef50_A0NJV2 Cluster: O-succinylhomoserine thiol-lyase; n=2; ... 106 4e-22
UniRef50_Q96VU8 Cluster: Cystathionine beta-lyase; n=3; Pezizomy... 105 6e-22
UniRef50_Q89V23 Cluster: O-acetylhomoserine sulfhydrylase; n=13;... 105 9e-22
UniRef50_Q2AGF7 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 105 1e-21
UniRef50_A7H124 Cluster: Methionine gamma-lyase; n=2; Campylobac... 105 1e-21
UniRef50_A1HQW4 Cluster: Cystathionine gamma-synthase; n=1; Ther... 105 1e-21
UniRef50_A5G8H3 Cluster: O-acetylhomoserine aminocarboxypropyltr... 104 1e-21
UniRef50_Q12L75 Cluster: Methionine gamma-lyase; n=1; Shewanella... 103 5e-21
UniRef50_A0LLP6 Cluster: Cystathionine gamma-synthase; n=1; Synt... 103 5e-21
UniRef50_Q0ALD7 Cluster: Cystathionine gamma-synthase; n=2; Hyph... 101 1e-20
UniRef50_A4EYE9 Cluster: Cystathionine beta-lyase/cystathionine ... 101 1e-20
UniRef50_Q5UZS6 Cluster: Cystathionine gamma-synthase; n=3; cell... 101 1e-20
UniRef50_Q65SV6 Cluster: Putative uncharacterized protein; n=1; ... 100 2e-20
UniRef50_Q9KEQ0 Cluster: Methionine gamma lyase; n=13; Bacillace... 100 3e-20
UniRef50_Q9K024 Cluster: Cystathionine gamma-synthase; n=4; Neis... 100 3e-20
UniRef50_Q8G436 Cluster: Possible cystathionine gamma lyase; n=3... 100 3e-20
UniRef50_Q67R76 Cluster: Cystathionine gamma-lyase; n=13; Bacter... 99 4e-20
UniRef50_A3U7R8 Cluster: O-acetylhomoserine sulfhydrylase; n=8; ... 100 6e-20
UniRef50_P44502 Cluster: Cystathionine gamma-synthase (EC 2.5.1.... 99 7e-20
UniRef50_P13254 Cluster: Methionine gamma-lyase; n=33; cellular ... 99 7e-20
UniRef50_A6YH84 Cluster: Cystathionine gamma-synthase; n=2; Lact... 99 1e-19
UniRef50_A1ZDN6 Cluster: Cystathionine beta-lyase; n=1; Microsci... 99 1e-19
UniRef50_O94350 Cluster: Cystathionine beta-lyase; n=27; cellula... 99 1e-19
UniRef50_Q1J8Q9 Cluster: Cystathionine beta-lyase; n=14; Bacilli... 98 1e-19
UniRef50_A0JSB0 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 96 5e-19
UniRef50_Q181I0 Cluster: Methionine gamma-lyase; n=2; Clostridiu... 96 7e-19
UniRef50_Q49UL3 Cluster: Cystathionine beta-lyase cystathionine ... 95 1e-18
UniRef50_A5KK19 Cluster: Putative uncharacterized protein; n=1; ... 95 2e-18
UniRef50_Q5K6Y9 Cluster: Cystathionine gamma-lyase, putative; n=... 94 2e-18
UniRef50_Q5QU17 Cluster: Methionine gamma-lyase; n=29; cellular ... 93 4e-18
UniRef50_Q97PS4 Cluster: Transulfuration enzyme family protein; ... 92 8e-18
UniRef50_A7DB98 Cluster: Cystathionine gamma-synthase; n=2; Meth... 92 8e-18
UniRef50_Q89XR2 Cluster: O-acetylhomoserine sulfhydrylase; n=24;... 91 1e-17
UniRef50_P06106 Cluster: Protein MET17 [Includes: O-acetylhomose... 91 1e-17
UniRef50_P00935 Cluster: Cystathionine gamma-synthase (EC 2.5.1.... 91 2e-17
UniRef50_A1ID11 Cluster: Cystathionine gamma-synthase; n=1; Cand... 90 3e-17
UniRef50_A5WG79 Cluster: O-succinylhomoserine sulfhydrylase; n=6... 89 8e-17
UniRef50_Q9KFD9 Cluster: Cystathionine gamma-synthase; n=3; Baci... 89 1e-16
UniRef50_Q8RI67 Cluster: Cystathionine beta-lyase; n=2; Bacteria... 88 1e-16
UniRef50_Q8G805 Cluster: Cystathionine beta-lyase; n=2; Bifidoba... 88 1e-16
UniRef50_Q31RB7 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 88 1e-16
UniRef50_A6W1L9 Cluster: Cystathionine gamma-synthase; n=10; Bac... 88 2e-16
UniRef50_Q7WKX4 Cluster: Cys/Met metabolism PLP-dependent enzyme... 87 3e-16
UniRef50_UPI0000E46EAD Cluster: PREDICTED: similar to methionine... 86 7e-16
UniRef50_A3VS82 Cluster: Cystathionine gamma-synthase; n=1; Parv... 86 7e-16
UniRef50_Q1IZN0 Cluster: Cystathionine gamma-synthase; n=1; Dein... 85 1e-15
UniRef50_A5MZA3 Cluster: O-acetyl-L-homoserine sulfhydrylase-rel... 85 1e-15
UniRef50_P55218 Cluster: O-succinylhomoserine sulfhydrylase; n=9... 85 1e-15
UniRef50_Q28Q09 Cluster: Cystathionine gamma-synthase; n=7; Rhod... 85 1e-15
UniRef50_O15564 Cluster: Methionine gamma-lyase; n=2; Trichomona... 85 1e-15
UniRef50_Q67QQ8 Cluster: Cystathionine gamma-lyase; n=1; Symbiob... 84 2e-15
UniRef50_Q1ITX7 Cluster: Cystathionine gamma-lyase; n=1; Acidoba... 83 4e-15
UniRef50_A6NZI8 Cluster: Putative uncharacterized protein; n=1; ... 83 4e-15
UniRef50_Q9RSD8 Cluster: O-acetylhomoserine (Thiol)-lyase/O-acet... 83 5e-15
UniRef50_Q8R9M2 Cluster: Cystathionine beta-lyases/cystathionine... 83 5e-15
UniRef50_Q5NPR0 Cluster: Cystathionine beta-lyases; n=5; Sphingo... 83 5e-15
UniRef50_A4FF27 Cluster: Methionine gamma-lyase; n=1; Saccharopo... 83 5e-15
UniRef50_P55217 Cluster: Cystathionine gamma-synthase, chloropla... 83 5e-15
UniRef50_A7INF9 Cluster: O-acetylhomoserine aminocarboxypropyltr... 83 7e-15
UniRef50_Q1VZU8 Cluster: Cystathionine beta-lyase; n=12; Bactero... 82 9e-15
UniRef50_Q5WAZ1 Cluster: Methionine gamma-lyase; n=1; Bacillus c... 82 1e-14
UniRef50_Q7VIG9 Cluster: O-acetylhomoserine (Thiol)-lyase MetY; ... 81 2e-14
UniRef50_A5WGJ5 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 81 2e-14
UniRef50_Q86D27 Cluster: Methionine gamma-lyase 2; n=3; Entamoeb... 81 2e-14
UniRef50_Q67KY0 Cluster: O-acetylhomoserine sulfhydrylase; n=28;... 81 2e-14
UniRef50_Q4AEY8 Cluster: Cystathionine gamma-synthase; n=1; Chlo... 81 2e-14
UniRef50_A4CKV8 Cluster: Cystathionine beta-lyase; n=11; Bactero... 81 2e-14
UniRef50_Q8EM13 Cluster: O-acetylhomoserine sulfhydrylase; n=86;... 81 3e-14
UniRef50_Q5QWY7 Cluster: Cystathionine gamma-synthase; n=5; Prot... 81 3e-14
UniRef50_A7S3X8 Cluster: Predicted protein; n=1; Nematostella ve... 81 3e-14
UniRef50_Q5UZ20 Cluster: O-acetylhomoserine (Thiol)-lyase; n=10;... 81 3e-14
UniRef50_Q0B7N7 Cluster: Cystathionine gamma-synthase; n=4; Beta... 80 4e-14
UniRef50_Q5LWC9 Cluster: Cys/Met metabolism PLP-dependent enzyme... 80 5e-14
UniRef50_A6LZ85 Cluster: O-acetylhomoserine aminocarboxypropyltr... 80 5e-14
UniRef50_A1ZIW0 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 80 5e-14
UniRef50_Q399B4 Cluster: Cystathionine beta-lyase; n=15; Proteob... 79 6e-14
UniRef50_Q338K0 Cluster: Cys/Met metabolism PLP-dependent enzyme... 79 6e-14
UniRef50_A7TA32 Cluster: Predicted protein; n=1; Nematostella ve... 79 6e-14
UniRef50_Q89VE2 Cluster: O-succinylhomoserine sulfhydrylase; n=7... 79 1e-13
UniRef50_Q895W3 Cluster: O-acetylhomoserine sulfhydrylase; n=40;... 79 1e-13
UniRef50_Q6W1U5 Cluster: Cystathionine gamma-synthase; n=2; Prot... 79 1e-13
UniRef50_Q46V95 Cluster: Cystathionine beta-lyase, bacterial; n=... 78 1e-13
UniRef50_A2Z703 Cluster: Putative uncharacterized protein; n=3; ... 78 1e-13
UniRef50_Q97MT9 Cluster: O-acetylhomoserine sulfhydrylase; n=4; ... 78 2e-13
UniRef50_Q2S2T9 Cluster: Cystathionine beta-lyase MetC; n=1; Sal... 77 3e-13
UniRef50_A0L907 Cluster: Cystathionine gamma-synthase; n=1; Magn... 77 3e-13
UniRef50_Q0SFV6 Cluster: O-acetylhomoserine aminocarboxypropyltr... 77 3e-13
UniRef50_A0V4A3 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 77 3e-13
UniRef50_Q3JCU1 Cluster: Cystathionine gamma-synthase; n=1; Nitr... 77 5e-13
UniRef50_Q4PK57 Cluster: Predicted cystathionine beta-lyase; n=1... 77 5e-13
UniRef50_UPI0000E47CE2 Cluster: PREDICTED: similar to cystathion... 76 6e-13
UniRef50_Q7X137 Cluster: Cystathionine gamma lyase-like protein;... 76 6e-13
UniRef50_A4AA77 Cluster: Cystathionine beta-lyase; n=2; Bacteria... 76 6e-13
UniRef50_A1SMU4 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 76 6e-13
UniRef50_A1A0Q5 Cluster: Cystathionine beta-lyase; n=2; Bifidoba... 76 6e-13
UniRef50_P53101 Cluster: Cystathionine beta-lyase; n=5; Saccharo... 76 8e-13
UniRef50_Q8FRS9 Cluster: O-acetylhomoserine sulfhydrylase; n=8; ... 75 1e-12
UniRef50_Q7M9C8 Cluster: O-ACETYLHOMOSERINE SULFHYDRYLASE; n=1; ... 75 1e-12
UniRef50_Q1AT24 Cluster: Cystathionine gamma-synthase; n=2; Bact... 75 1e-12
UniRef50_A6GHC8 Cluster: Cystathionine gamma-synthase; n=1; Ples... 75 1e-12
UniRef50_A4AND2 Cluster: Cystathionine gamma-lyase; n=2; cellula... 75 1e-12
UniRef50_Q8RI68 Cluster: Cystathionine gamma-synthase; n=1; Fuso... 75 2e-12
UniRef50_A5CVL3 Cluster: O-succinylhomoserine sulfhydrylase; n=3... 75 2e-12
UniRef50_Q1ELY9 Cluster: Cystathionine beta-lyases/cystathionine... 74 2e-12
UniRef50_UPI0000E0F9F5 Cluster: hypothetical protein OM2255_2257... 74 3e-12
UniRef50_Q2JBH0 Cluster: O-succinylhomoserine sulfhydrylase; n=1... 74 3e-12
UniRef50_A3UCA9 Cluster: Cystathionine gamma-synthase; n=2; Hyph... 74 3e-12
UniRef50_A3K0Q5 Cluster: O-succinylhomoserine sulfhydrylase; n=3... 74 3e-12
UniRef50_A6UGP2 Cluster: Cystathionine gamma-synthase; n=1; Sino... 73 4e-12
UniRef50_A0JSU6 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 73 4e-12
UniRef50_A7DHV1 Cluster: O-acetylhomoserine aminocarboxypropyltr... 73 6e-12
UniRef50_Q3IV09 Cluster: O-acetylhomoserine sulfhydrylase; n=1; ... 73 7e-12
UniRef50_Q76K51 Cluster: O-acetyl-L-homoserine sulfhydrylase; n=... 73 7e-12
UniRef50_A0LY60 Cluster: O-succinylhomoserine sulfhydrylase; n=1... 72 1e-11
UniRef50_A2BL10 Cluster: Methionine gamma-lyase; n=1; Hypertherm... 72 1e-11
UniRef50_A5CMC2 Cluster: O-acetylhomoserine (Thiol)-lyase; n=2; ... 72 1e-11
UniRef50_Q11C77 Cluster: Cystathionine beta-lyase; n=1; Mesorhiz... 71 2e-11
UniRef50_A6GRN0 Cluster: Cystathionine beta-lyase; n=1; Limnobac... 71 2e-11
UniRef50_Q67VG6 Cluster: Putative O-succinylhomoserine (Thiol)-l... 71 2e-11
UniRef50_O02215 Cluster: Putative uncharacterized protein; n=3; ... 71 2e-11
UniRef50_Q7M844 Cluster: O-ACETYLHOMOSERINE (THIOL)-LYASE; n=1; ... 71 3e-11
UniRef50_A5MZ94 Cluster: O-acetyl-L-homoserine sulfhydrylase-rel... 71 3e-11
UniRef50_Q6AJ03 Cluster: Probable cystathionine beta-lyase; n=1;... 70 5e-11
UniRef50_O69592 Cluster: O-succinylhomoserine sulfhydrylase; n=1... 70 5e-11
UniRef50_A5V1Q1 Cluster: Cystathionine gamma-synthase; n=2; Rose... 70 5e-11
UniRef50_Q97CC7 Cluster: Cystathionine beta lyase / O-succinylho... 70 5e-11
UniRef50_Q7UQA0 Cluster: Cystathionine gamma-synthase; n=4; Bact... 69 7e-11
UniRef50_Q8J0B2 Cluster: Homocysteine synthase-like protein; n=2... 69 9e-11
UniRef50_A0VE37 Cluster: Cystathionine beta-lyase; n=2; Comamona... 69 1e-10
UniRef50_Q7P3Q8 Cluster: Methionine gamma-lyase; n=1; Fusobacter... 68 2e-10
UniRef50_A5ZYG7 Cluster: Putative uncharacterized protein; n=1; ... 68 2e-10
UniRef50_P43623 Cluster: Putative cystathionine beta-lyase; n=11... 68 2e-10
UniRef50_Q82YZ5 Cluster: Cystathionine gamma-synthase, putative;... 68 2e-10
UniRef50_A3JID5 Cluster: Cystathionine beta-lyase; n=3; Marinoba... 68 2e-10
UniRef50_Q9V088 Cluster: MetB cystathionine gamma-synthase (EC 4... 67 3e-10
UniRef50_Q1GQF1 Cluster: Cystathionine beta-lyase; n=1; Sphingop... 67 4e-10
UniRef50_Q1GNK9 Cluster: Cystathionine beta-lyase; n=4; Sphingom... 67 4e-10
UniRef50_A1SSS1 Cluster: Cystathionine beta-lyase; n=10; Gammapr... 66 5e-10
UniRef50_A1I7W3 Cluster: O-acetylhomoserine aminocarboxypropyltr... 66 5e-10
UniRef50_Q11FS5 Cluster: Cystathionine beta-lyase; n=5; Alphapro... 66 6e-10
UniRef50_Q45278 Cluster: Aminotransferase and dihydrorhizobitoxi... 65 1e-09
UniRef50_A5EU95 Cluster: Cystathionine beta-lyase; n=1; Bradyrhi... 65 1e-09
UniRef50_UPI00015BB00D Cluster: cystathionine gamma-synthase; n=... 65 1e-09
UniRef50_Q493X0 Cluster: Beta-cystathionase; n=2; Enterobacteria... 65 1e-09
UniRef50_Q47S97 Cluster: Cystathionine gamma-synthase; n=1; Ther... 65 1e-09
UniRef50_A3SR24 Cluster: Cystathionine gamma-synthase; n=3; Alph... 65 1e-09
UniRef50_Q5FUW3 Cluster: Cystathionine beta-lyase; n=3; Acetobac... 64 3e-09
UniRef50_Q1IQ69 Cluster: Cystathionine beta-lyase; n=6; Bacteria... 64 3e-09
UniRef50_Q9SGU9 Cluster: F1N19.23; n=7; Magnoliophyta|Rep: F1N19... 64 3e-09
UniRef50_Q6N7A9 Cluster: Putative homocysteine synthase; n=1; Rh... 63 4e-09
UniRef50_Q97W69 Cluster: O-succinylhomoserine (Thiol)-lyase; n=5... 63 4e-09
UniRef50_Q2K0N3 Cluster: Cystathionine gamma-synthase protein; n... 63 6e-09
UniRef50_A5G088 Cluster: Cystathionine gamma-synthase; n=1; Acid... 62 1e-08
UniRef50_Q7WM51 Cluster: Cystathionase beta-lyase; n=3; Proteoba... 61 2e-08
UniRef50_A6Q4H8 Cluster: O-acetylhomoserine sulfhydrylase; n=3; ... 61 2e-08
UniRef50_A6PIC3 Cluster: Cystathionine beta-lyase; n=1; Shewanel... 61 2e-08
UniRef50_Q52811 Cluster: Putative cystathionine beta-lyase; n=35... 61 2e-08
UniRef50_Q8NM00 Cluster: Cystathionine beta-lyases/cystathionine... 61 2e-08
UniRef50_Q9X0Z7 Cluster: Cystathionine gamma-synthase; n=2; Ther... 60 3e-08
UniRef50_A7CL93 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 60 4e-08
UniRef50_Q1NS60 Cluster: O-acetylhomoserine aminocarboxypropyltr... 59 7e-08
UniRef50_A0JYV8 Cluster: Cystathionine gamma-synthase; n=8; Acti... 59 7e-08
UniRef50_Q4Q511 Cluster: Cystathionine beta-lyase, putative; n=3... 59 7e-08
UniRef50_Q07703 Cluster: Cystathionine beta-lyase; n=6; Burkhold... 59 7e-08
UniRef50_Q5GSE3 Cluster: Cystathionine beta-lyase; n=5; Wolbachi... 58 1e-07
UniRef50_Q3A8R5 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 58 1e-07
UniRef50_A1W861 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 58 2e-07
UniRef50_P44527 Cluster: Cystathionine beta-lyase; n=78; Gammapr... 58 2e-07
UniRef50_Q98LV9 Cluster: Methionine gamma lyase; n=4; Rhizobiale... 57 3e-07
UniRef50_A3X9V5 Cluster: Cystathionine gamma-synthase; n=12; Rho... 57 3e-07
UniRef50_Q979X4 Cluster: Cystathionine beta lyase / O-succinylho... 57 3e-07
UniRef50_Q6MN74 Cluster: Cys/Met metabolism lyase; n=1; Bdellovi... 56 5e-07
UniRef50_Q62JZ5 Cluster: Cystathionine beta-lyase; n=37; Burkhol... 56 5e-07
UniRef50_Q98K64 Cluster: Methionine gamma-lyase; n=13; Bacteria|... 56 7e-07
UniRef50_Q7W586 Cluster: Cystathionine beta-lyase; n=3; Bordetel... 56 7e-07
UniRef50_A6QZA3 Cluster: Cystathionine gamma-lyase; n=1; Ajellom... 56 9e-07
UniRef50_Q6L1U0 Cluster: Cystathionine beta-lyase; n=1; Picrophi... 55 1e-06
UniRef50_Q59829 Cluster: Putative cystathionine gamma-lyase; n=8... 55 1e-06
UniRef50_Q1QM61 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 55 2e-06
UniRef50_Q1DAY0 Cluster: Cys/Met metabolism PLP-dependent enzyme... 55 2e-06
UniRef50_Q5PBE9 Cluster: Cystathionine beta-lyase; n=1; Anaplasm... 54 2e-06
UniRef50_Q1GVW8 Cluster: Cystathionine gamma-lyase; n=15; Bacter... 54 3e-06
UniRef50_Q0APK0 Cluster: Cystathionine beta-lyase; n=1; Maricaul... 54 3e-06
UniRef50_A0H5P3 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 54 3e-06
UniRef50_Q6F7Q9 Cluster: Putative cystathionine beta-lyase, PLP-... 54 4e-06
UniRef50_Q11MH2 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 54 4e-06
UniRef50_Q1V2M7 Cluster: Cystathionine beta-lyase; n=2; Candidat... 53 6e-06
UniRef50_A6GJL1 Cluster: Methionine gamma-lyase; n=1; Plesiocyst... 53 6e-06
UniRef50_A3VUE2 Cluster: Cystathionine beta-lyase; n=1; Parvular... 52 1e-05
UniRef50_A3PXR9 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 52 1e-05
UniRef50_Q13Z52 Cluster: Cystathionine beta-lyase; n=2; Burkhold... 52 1e-05
UniRef50_A7HB44 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 52 1e-05
UniRef50_Q67LU9 Cluster: Cystathionine beta-lyase; n=2; Bacteria... 51 2e-05
UniRef50_Q83WD5 Cluster: Putative cystathionine/methionine gamma... 51 3e-05
UniRef50_A7H1V2 Cluster: Cystathionine beta-lyase; n=15; Campylo... 50 3e-05
UniRef50_Q62BJ4 Cluster: Trans-sulfuration enzyme family protein... 50 6e-05
UniRef50_A1CUZ3 Cluster: Homocysteine synthase, putative; n=1; N... 50 6e-05
UniRef50_Q01X62 Cluster: Cystathionine gamma-synthase; n=1; Soli... 49 8e-05
UniRef50_A2Y9X5 Cluster: Putative uncharacterized protein; n=1; ... 49 8e-05
UniRef50_Q5NQQ3 Cluster: Cystathionine beta-lyase; n=41; Proteob... 48 1e-04
UniRef50_Q0C2A8 Cluster: Cystathionine beta-lyase; n=1; Hyphomon... 48 1e-04
UniRef50_A6W2A4 Cluster: Cystathionine beta-lyase; n=1; Marinomo... 48 1e-04
UniRef50_A5W0L6 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 48 1e-04
UniRef50_Q98KA4 Cluster: Probable cystathionine/methionine gamma... 48 2e-04
UniRef50_A4QZ48 Cluster: Putative uncharacterized protein; n=1; ... 48 2e-04
UniRef50_Q5LN68 Cluster: Cys/Met metabolism PLP-dependent enzyme... 47 3e-04
UniRef50_Q8G801 Cluster: Putative uncharacterized protein; n=2; ... 46 7e-04
UniRef50_Q26GX1 Cluster: Cys/Met metabolism PLP-dependent enzyme... 44 0.002
UniRef50_A4S3Y0 Cluster: Putative 2nd cystathione gamma synthase... 42 0.009
UniRef50_O58821 Cluster: Putative uncharacterized protein PH1094... 41 0.027
UniRef50_Q1VY21 Cluster: Coproporphyrinogen III oxidase; n=1; Ps... 40 0.036
UniRef50_Q58097 Cluster: Probable aspartate aminotransferase 2; ... 40 0.036
UniRef50_A4AZ61 Cluster: Homocysteine synthase; n=7; Gammaproteo... 39 0.084
UniRef50_Q0B5H9 Cluster: Cys/Met metabolism pyridoxal-phosphate-... 38 0.15
UniRef50_O14209 Cluster: Uncharacterized aminotransferase C6B12.... 38 0.19
UniRef50_Q98AR6 Cluster: Aspartate transaminase; n=2; Mesorhizob... 36 0.78
UniRef50_Q7X1G1 Cluster: Lfe147p1; n=2; Leptospirillum|Rep: Lfe1... 36 0.78
UniRef50_A7TP63 Cluster: Putative uncharacterized protein; n=1; ... 36 0.78
UniRef50_Q2BCQ0 Cluster: Putative uncharacterized protein; n=1; ... 36 1.0
UniRef50_Q3T4B9 Cluster: NADH-ubiquinone oxidoreductase chain 4;... 36 1.0
UniRef50_Q5FUM7 Cluster: Prolyl-oligopeptidase; n=1; Gluconobact... 35 1.4
UniRef50_Q9YA71 Cluster: Cystathionine gamma-synthase; n=1; Aero... 35 1.4
UniRef50_A7DS52 Cluster: Aminotransferase, class I and II; n=1; ... 35 1.8
UniRef50_Q60317 Cluster: Probable aspartate aminotransferase 1; ... 35 1.8
UniRef50_Q8R6L3 Cluster: Selenocysteine lyase; n=7; Clostridia|R... 34 2.4
UniRef50_A6C1Z0 Cluster: Selenocysteine lyase; n=1; Planctomyces... 34 3.1
UniRef50_A3JA39 Cluster: O-acetylhomoserine/O-acetylserine sulfh... 34 3.1
UniRef50_Q46955 Cluster: O antigen polymerase; n=1; Escherichia ... 33 4.2
UniRef50_Q6BZ38 Cluster: Debaryomyces hansenii chromosome A of s... 33 4.2
UniRef50_A4RC33 Cluster: Putative uncharacterized protein; n=2; ... 33 4.2
UniRef50_UPI00015B9512 Cluster: UPI00015B9512 related cluster; n... 33 5.5
UniRef50_A7GCC1 Cluster: Dipeptidase; n=11; Bacteria|Rep: Dipept... 33 5.5
UniRef50_Q5Z958 Cluster: Putative uncharacterized protein P0659D... 33 5.5
UniRef50_Q8A2D0 Cluster: Aspartate aminotransferase; n=1; Bacter... 32 9.6
UniRef50_Q1IU09 Cluster: Putative uncharacterized protein; n=1; ... 32 9.6
UniRef50_Q9M9N8 Cluster: NAM-like protein; n=3; Arabidopsis thal... 32 9.6
UniRef50_A7NVA1 Cluster: Chromosome chr18 scaffold_1, whole geno... 32 9.6
UniRef50_P47164 Cluster: Cystathionine gamma-synthase (EC 2.5.1.... 32 9.6
>UniRef50_Q17DR1 Cluster: Cystathionine beta-lyase; n=6;
Coelomata|Rep: Cystathionine beta-lyase - Aedes aegypti
(Yellowfever mosquito)
Length = 438
Score = 221 bits (539), Expect = 1e-56
Identities = 101/177 (57%), Positives = 127/177 (71%)
Frame = +2
Query: 86 VENKIGMADHGFLKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFE 265
+ N + A+ GF Q GFAT AIH GQ+ E+W S AVV PI STTFKQ PA+H G+E
Sbjct: 6 ITNGVERAEDGFRAQPKGFATKAIHVGQDAEQWKSRAVVPPISMSTTFKQFGPAQHAGYE 65
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNR 445
YGRSGNPTR+ LE CLA+LD GKYGLTF+S + GDHIV+ DD+YGGTNR
Sbjct: 66 YGRSGNPTRDVLERCLASLDNGKYGLTFSSGLGVTTTVITMLSAGDHIVAGDDLYGGTNR 125
Query: 446 LLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
LLR+V ++ I F D T++ KV+ A++ NTK+ WIETPTNPLLKV+DIEA+ ++A
Sbjct: 126 LLRKVAMKMNIEVDFVDCTDLAKVEAAVKPNTKLFWIETPTNPLLKVIDIEAVSEVA 182
>UniRef50_P32929 Cluster: Cystathionine gamma-lyase; n=38; cellular
organisms|Rep: Cystathionine gamma-lyase - Homo sapiens
(Human)
Length = 405
Score = 190 bits (464), Expect = 2e-47
Identities = 90/169 (53%), Positives = 109/169 (64%)
Frame = +2
Query: 107 ADHGFLKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNP 286
+ GFL FAT AIH GQ+PE+W S AVV PI STTFKQ AP +H+GFEY RSGNP
Sbjct: 7 SSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNP 66
Query: 287 TRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIA 466
TRN LE+ +AALDG KY L FAS GD I+ DDVYGGTNR RQV +
Sbjct: 67 TRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVAS 126
Query: 467 RLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
G+ +F D + I+ ++ A+ TK++WIETPTNP KV+DIE I
Sbjct: 127 EFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHI 175
>UniRef50_UPI0000F2BB70 Cluster: PREDICTED: similar to Chain A,
Crystal Structure Of Human Cystathionine Gamma Lyase;
n=3; Mammalia|Rep: PREDICTED: similar to Chain A,
Crystal Structure Of Human Cystathionine Gamma Lyase -
Monodelphis domestica
Length = 500
Score = 189 bits (460), Expect = 5e-47
Identities = 91/173 (52%), Positives = 109/173 (63%)
Frame = +2
Query: 95 KIGMADHGFLKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGR 274
K G D GF P FAT AIHA QEPE+W+ VV PI STTFKQ AP H GFEY R
Sbjct: 3 KGGTPDGGFQPPFPHFATQAIHAAQEPEQWSGQPVVAPISLSTTFKQTAPGCHAGFEYSR 62
Query: 275 SGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLR 454
SGNPTRN LE+ +A LDG KY L FAS GDHIV +DVYGGTNR R
Sbjct: 63 SGNPTRNCLEKAVATLDGAKYCLAFASGLAATLNITHLLKAGDHIVCMNDVYGGTNRYFR 122
Query: 455 QVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
+V LG+ +F D + +E + A+ TK++WIETPTNP LKV+DI+ ++
Sbjct: 123 RVATELGLKISFVDCSKLELLNAAITPETKLVWIETPTNPGLKVIDIKGCAQV 175
>UniRef50_Q8VCN5 Cluster: Cystathionine gamma-lyase; n=39;
Eukaryota|Rep: Cystathionine gamma-lyase - Mus musculus
(Mouse)
Length = 398
Score = 180 bits (439), Expect = 2e-44
Identities = 85/166 (51%), Positives = 107/166 (64%)
Frame = +2
Query: 116 GFLKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRN 295
GFL FAT AIH GQEPE+WNS AVV PI +TTFKQ P + +GFEY RSGNPTRN
Sbjct: 9 GFLPSFQHFATQAIHVGQEPEQWNSRAVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRN 68
Query: 296 TLEECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLG 475
LE+ +AALDG K+ L FAS GD I+ D+VYGGTNR R+V + G
Sbjct: 69 CLEKAVAALDGAKHSLAFASGLAATITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFG 128
Query: 476 INTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
+ +F D + + ++ A+ TK++WIETPTNP LK+ DI A +I
Sbjct: 129 LKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQI 174
>UniRef50_Q23CV0 Cluster: Cystathionine beta-lyase; n=3;
Oligohymenophorea|Rep: Cystathionine beta-lyase -
Tetrahymena thermophila SB210
Length = 409
Score = 166 bits (403), Expect = 4e-40
Identities = 80/167 (47%), Positives = 108/167 (64%), Gaps = 2/167 (1%)
Frame = +2
Query: 125 KQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE-HTGFEYGRSGNPTRNTL 301
K+ GFAT AIHAGQ+P++ + + V PI STTF Q AP + ++ +EY R G PTR+
Sbjct: 18 KKNKGFATKAIHAGQDPDQVHGSVNV-PIHLSTTFAQKAPTDFYSQYEYARGGTPTRHAF 76
Query: 302 EECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQ-VIARLGI 478
EEC+AA + G+Y + F+S HI+ SDDVYGGTNR +R+ + +
Sbjct: 77 EECIAACENGEYAIAFSSGCAAMTCVLHSLPKESHIIVSDDVYGGTNRYMRRFAVEKFNF 136
Query: 479 NTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
N F D T+ E KNA +ENT ++WIETPTNPL+K+VDIEA+V I R
Sbjct: 137 NVEFVDLTDTEAFKNAFKENTALVWIETPTNPLIKLVDIEALVNITR 183
>UniRef50_P24601 Cluster: Probable cystathionine gamma-synthase (EC
2.5.1.48) (CGS) (O- succinylhomoserine (thiol)-lyase);
n=52; cellular organisms|Rep: Probable cystathionine
gamma-synthase (EC 2.5.1.48) (CGS) (O-
succinylhomoserine (thiol)-lyase) - Herpetosiphon
aurantiacus (Herpetosiphon giganteus)
Length = 319
Score = 164 bits (398), Expect = 2e-39
Identities = 76/161 (47%), Positives = 105/161 (65%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLA 316
GFAT AIHAGQ+PE + AV+ PI ++T+ Q +HTG+EY R+ NPTR L+ CLA
Sbjct: 4 GFATRAIHAGQDPESV-TGAVIVPIYQTSTYAQRGVGDHTGYEYSRTDNPTRTALQTCLA 62
Query: 317 ALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTD 496
AL+ K+ L FAS GDH++ DDVYGGT RL ++V+ G++ F D
Sbjct: 63 ALEEAKHALVFASGLGASTTLMLMLKAGDHVICGDDVYGGTYRLFQRVMTEHGLSFDFID 122
Query: 497 FTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ E V+ A++ NT++IW+ETPTNPLLK+ I AI ++AR
Sbjct: 123 MADPEAVRAAIKPNTRLIWLETPTNPLLKLAPIAAITRVAR 163
>UniRef50_Q129P6 Cluster: Cystathionine gamma-synthase; n=11;
cellular organisms|Rep: Cystathionine gamma-synthase -
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 381
Score = 161 bits (392), Expect = 9e-39
Identities = 74/159 (46%), Positives = 105/159 (66%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAA 319
F+T AIHAGQ P + A++TP+ S+TF Q AP +H G++YGR+ NPTR+ LE +AA
Sbjct: 3 FSTQAIHAGQ-PADPTTGAIMTPVYLSSTFVQQAPGQHKGYDYGRTANPTRSALEANIAA 61
Query: 320 LDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDF 499
L+ G YGL FAS + GDH+V D+YGGT RL+ +V AR GI +F D
Sbjct: 62 LEDGTYGLAFASGLAAESTVLQSLSSGDHVVCGQDLYGGTYRLMTKVFARFGIEASFVDA 121
Query: 500 TNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
T+ ++ A++ T+++W+ETP+NPLL V DI AI ++A
Sbjct: 122 TSPGAIRAALRPQTRLVWLETPSNPLLTVCDIAAIAQLA 160
>UniRef50_P56069 Cluster: Cystathionine gamma-synthase (EC 2.5.1.48)
(CGS) (O-succinylhomoserine (thiol)-lyase); n=24;
Bacteria|Rep: Cystathionine gamma-synthase (EC 2.5.1.48)
(CGS) (O-succinylhomoserine (thiol)-lyase) -
Helicobacter pylori (Campylobacter pylori)
Length = 380
Score = 140 bits (339), Expect = 2e-32
Identities = 67/158 (42%), Positives = 95/158 (60%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALD 325
T IH G E + AV PI ++T++Q A H G+EY RSGNPTR LEE +A L+
Sbjct: 5 TKLIHGGIS-EDATTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLE 63
Query: 326 GGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTN 505
GG G FAS GDH++ DDVYGGT RL QV+ + G++ T D ++
Sbjct: 64 GGVKGFAFASGLAGIHAVFSLLQSGDHVLLGDDVYGGTFRLFNQVLVKNGLSCTIIDTSD 123
Query: 506 IEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
I ++K A++ NTK +++ETP+NPLLK+ D+ +A+
Sbjct: 124 ISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAK 161
>UniRef50_Q97M10 Cluster: Cystathionine gamma-synthase; n=15;
Bacteria|Rep: Cystathionine gamma-synthase - Clostridium
acetobutylicum
Length = 384
Score = 139 bits (337), Expect = 4e-32
Identities = 63/160 (39%), Positives = 100/160 (62%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAA 319
F T A+H G+ + + A+ PI S+TF+ + TG++Y R+GNPTR+ +E+ +AA
Sbjct: 9 FETKAVH-GESGFESRTGAISYPIYQSSTFRHEGLNKGTGYDYSRTGNPTRDEVEKTVAA 67
Query: 320 LDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDF 499
L+ G+ L ++S GDHI+ SDD+YGGT R+ ++ GI T+TD
Sbjct: 68 LENGRACLAYSSGMAAISSVLTIFKGGDHIIVSDDLYGGTYRIFEEIYEHYGIEVTYTDT 127
Query: 500 TNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
T+ E ++ ++ENTK I++ETPTNPL+K+ DI + K+A+
Sbjct: 128 TSTENIEKELRENTKAIYLETPTNPLMKITDIREVSKLAK 167
>UniRef50_Q5L1M8 Cluster: Cystathionine beta-lyase; n=42;
Bacteria|Rep: Cystathionine beta-lyase - Geobacillus
kaustophilus
Length = 393
Score = 138 bits (334), Expect = 1e-31
Identities = 67/166 (40%), Positives = 103/166 (62%)
Frame = +2
Query: 122 LKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTL 301
++Q+ F+T +H + ++ + AV PI ++TF Q ++Y RS NPTR L
Sbjct: 1 MEQEWAFSTKLLHNEWKVDR-ETGAVSVPIQHASTFHQFDFDSFGKYDYSRSSNPTREAL 59
Query: 302 EECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGIN 481
EE +AAL+GG G FAS + GDH++ ++DVYGGT R++ +V+ R GI
Sbjct: 60 EETIAALEGGTRGFAFASGMAAISTAFLLLSKGDHVLVTEDVYGGTYRMITEVLGRFGIE 119
Query: 482 TTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
TF D T++ V ++ NTK+I++ETP+NPLLKV DI+ +VK+A+
Sbjct: 120 YTFVDMTDLNAVAENIRPNTKVIYMETPSNPLLKVTDIQGVVKLAK 165
>UniRef50_Q6N7A1 Cluster: Cystathionine gamma-lyase; n=52; cellular
organisms|Rep: Cystathionine gamma-lyase -
Rhodopseudomonas palustris
Length = 390
Score = 136 bits (329), Expect = 4e-31
Identities = 71/167 (42%), Positives = 97/167 (58%), Gaps = 1/167 (0%)
Frame = +2
Query: 122 LKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTL 301
L+Q+ G T A+H GQ + + AV TPI ++TF Q AP H G+EY RS NPTR
Sbjct: 7 LRQR-GANTRAVHGGQHFDP-ATGAVTTPIYATSTFVQSAPGVHKGYEYARSQNPTRAAF 64
Query: 302 EECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIAR-LGI 478
E +A + G G FAS G HIV+SDD+YGG+ RL +V + G+
Sbjct: 65 EAAIADAERGHAGFAFASGLAAEAALLEIAGQGSHIVASDDLYGGSWRLFHRVRSHSAGL 124
Query: 479 NTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
T D N++ +++A+Q NT IWIETP+NP L++ D+EAI I R
Sbjct: 125 TITHVDPANLDALRDAIQPNTAFIWIETPSNPTLRLADLEAIAAIGR 171
>UniRef50_Q1INQ0 Cluster: Cystathionine gamma-synthase; n=2;
Bacteria|Rep: Cystathionine gamma-synthase -
Acidobacteria bacterium (strain Ellin345)
Length = 385
Score = 135 bits (327), Expect = 7e-31
Identities = 67/164 (40%), Positives = 95/164 (57%)
Frame = +2
Query: 125 KQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLE 304
K+ GF+T +H GQEPE+ + V TST + G+EY R NPTR+ LE
Sbjct: 3 KKDSGFSTKCVHVGQEPEQLTGSVGVPIYATSTYAQDELGKPRLGYEYSRVSNPTRDRLE 62
Query: 305 ECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINT 484
+ LAAL+GG FAS GDH+V S +VYGG RL QV+ G+
Sbjct: 63 KNLAALEGGVDSKVFASGMAAVSAMCSLLKKGDHVVCSSNVYGGVPRLFNQVLVNYGLEF 122
Query: 485 TFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
T+ D ++++ + A++ +TK ++IETPTNPL+ + DIEAI +IA
Sbjct: 123 TYVDTSDLKATEKAIRRSTKYVYIETPTNPLMVLSDIEAISQIA 166
>UniRef50_A6LPZ9 Cluster: Cystathionine gamma-synthase; n=4;
Bacteria|Rep: Cystathionine gamma-synthase - Clostridium
beijerinckii NCIMB 8052
Length = 382
Score = 133 bits (322), Expect = 3e-30
Identities = 66/163 (40%), Positives = 93/163 (57%)
Frame = +2
Query: 131 KPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEEC 310
K F TIA+ +K + A+ PI S TFK TG++Y R+ NPTR E+
Sbjct: 4 KKSFETIAVSGVSGGDK-ETGAISFPIYQSATFKHHGLNNSTGYDYARAQNPTREEAEKT 62
Query: 311 LAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTF 490
LA L+GGK + F+S GDHI+ SDD+YGGT RL + G+ TF
Sbjct: 63 LAVLEGGKSAIGFSSGVAAITACIHLFKSGDHIILSDDLYGGTYRLFDDIFRDFGLEATF 122
Query: 491 TDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
D T + + N+++ENTK I IETP+NP++KV DI+A+ +I +
Sbjct: 123 VDTTITKNILNSIKENTKAILIETPSNPMMKVTDIKAVAEITK 165
>UniRef50_Q8KEI8 Cluster: Trans-sulfuration enzyme family protein;
n=8; Chlorobiaceae|Rep: Trans-sulfuration enzyme family
protein - Chlorobium tepidum
Length = 380
Score = 133 bits (321), Expect = 4e-30
Identities = 66/159 (41%), Positives = 93/159 (58%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAA 319
F TIAIH G PE + +V P+ ++TF +P+ E F Y R GNPTR+ LE LA
Sbjct: 3 FETIAIHDGNTPESC-TGSVTPPVYQTSTFARPSLDERGEFFYSRIGNPTRSALESTLAL 61
Query: 320 LDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDF 499
L+ GK+ TFAS GDH+VSS DVYGG+ R+ Q++ G+ T++
Sbjct: 62 LENGKHATTFASGVAAMMAAMQVLKPGDHVVSSLDVYGGSYRIFEQLMRPWGVETSYAAS 121
Query: 500 TNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
E ++ T+MIWIE+P+NPLL++ DI A+ +IA
Sbjct: 122 EATESYIECIRPETRMIWIESPSNPLLQICDIRALAEIA 160
>UniRef50_Q74EL7 Cluster: Cystathionine beta-lyase; n=5;
Bacteria|Rep: Cystathionine beta-lyase - Geobacter
sulfurreducens
Length = 378
Score = 133 bits (321), Expect = 4e-30
Identities = 65/161 (40%), Positives = 99/161 (61%), Gaps = 1/161 (0%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTG-FEYGRSGNPTRNTLEECLA 316
F T IH G+E + + A+ PI ++T++Q + +H G ++Y RS NPTR LEE +A
Sbjct: 3 FGTRIIHTGREIDP-TTGALSVPIYQTSTYRQES-VDHFGKYDYARSDNPTREALEETVA 60
Query: 317 ALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTD 496
L+ G G FAS + GDH+V +DVYGGT R L Q+ +RLG+ +TF D
Sbjct: 61 QLENGTRGFAFASGMAAISSTLLLFSPGDHLVVCEDVYGGTFRALTQLFSRLGVESTFVD 120
Query: 497 FTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
T+ ++ A + NTK +++ETP+NPL+K+ D+ A ++AR
Sbjct: 121 ATDTAAIEAAFRPNTKGLYLETPSNPLMKITDLAAAARLAR 161
>UniRef50_Q4A0K3 Cluster: Cystathionine gamma-synthase; n=4;
Bacteria|Rep: Cystathionine gamma-synthase -
Staphylococcus saprophyticus subsp. saprophyticus
(strain ATCC 15305 /DSM 20229)
Length = 381
Score = 131 bits (316), Expect = 1e-29
Identities = 67/159 (42%), Positives = 95/159 (59%), Gaps = 1/159 (0%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE-HTGFEYGRSGNPTRNTLEECLAAL 322
T IH GQ + + + AV TPI ++T+ Q + G+EY RS NPTR+ LE +A L
Sbjct: 5 TQLIHGGQTTDPY-TGAVTTPIYQTSTYMQDGIGDMRQGYEYSRSANPTRSALEGLIADL 63
Query: 323 DGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFT 502
+ G+ G F S + GDH++ + DVYGGT R L +V R GI+ F D T
Sbjct: 64 EQGESGFAFGSGMAAISAVIMLLDKGDHLLINSDVYGGTYRALTKVFNRFGIDAEFIDTT 123
Query: 503 NIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
NIE V+ ++ TKM++IETP+NPLL+V DI+ +IA+
Sbjct: 124 NIEAVEQYIKPETKMLYIETPSNPLLRVTDIKKSAEIAK 162
>UniRef50_Q9EWF9 Cluster: Cystathionine gamma-synthase; n=6;
Bacteria|Rep: Cystathionine gamma-synthase -
Streptomyces coelicolor
Length = 386
Score = 130 bits (315), Expect = 2e-29
Identities = 69/162 (42%), Positives = 93/162 (57%), Gaps = 2/162 (1%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE-HTGFEYGRSGNPTRNTLEECLA 316
F T+AIHAG + + AVV PI +T+KQ G+EY RS NPTR LEE LA
Sbjct: 12 FETLAIHAGNTADPL-TGAVVPPIYQVSTYKQDGVGGLRGGYEYSRSANPTRTALEENLA 70
Query: 317 ALDGGKYGLTFASXXXXXX-XXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFT 493
AL+GG+ GL FAS GDH+V +D YGGT RL +V R G+ +
Sbjct: 71 ALEGGRRGLAFASGLAAEDCLLRTLLRPGDHVVIPNDAYGGTFRLFAKVATRWGVEWSVA 130
Query: 494 DFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
D ++ V+ A+ TK +W+ETP+NPLL + DI + ++AR
Sbjct: 131 DTSDAAAVRAALTPKTKAVWVETPSNPLLGITDIAQVAQVAR 172
>UniRef50_Q1IQD6 Cluster: Cystathionine gamma-synthase; n=2;
Acidobacteria|Rep: Cystathionine gamma-synthase -
Acidobacteria bacterium (strain Ellin345)
Length = 390
Score = 130 bits (314), Expect = 3e-29
Identities = 67/172 (38%), Positives = 98/172 (56%), Gaps = 1/172 (0%)
Frame = +2
Query: 104 MADHGFLKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHT-GFEYGRSG 280
MAD +K+ GF TIA+HAG+ + ++ AV PI STTF++ + G+ Y R
Sbjct: 4 MADS--IKKSHGFQTIAVHAGRNVDP-STGAVAMPIYPSTTFERDTDGAFSRGYSYIRDA 60
Query: 281 NPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQV 460
NP R LE CL+AL+ G+ + F+S + GDH+V D+Y G L+ +
Sbjct: 61 NPNRKALEACLSALEVGEEAIAFSSGMGATFSVFQILSPGDHVVLHRDMYYGVRELINGI 120
Query: 461 IARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
R GI T D N+++ + A++ TK+ W+ETPTNPL++VV IE I IA
Sbjct: 121 FTRYGIQHTVVDMRNLDETRAAVRPGTKLFWLETPTNPLIEVVAIEPIAAIA 172
>UniRef50_Q838Z2 Cluster: Cystathionine beta-lyase; n=8;
Bacteria|Rep: Cystathionine beta-lyase - Enterococcus
faecalis (Streptococcus faecalis)
Length = 378
Score = 129 bits (312), Expect = 5e-29
Identities = 64/160 (40%), Positives = 95/160 (59%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAA 319
F T IH G + + AV PI ++TF+Q + +EY RSGNPTR+ LE +A
Sbjct: 3 FNTKLIHGGISKDT-TTGAVSVPIYQTSTFEQNGVGQPKEYEYSRSGNPTRHALETLIAE 61
Query: 320 LDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDF 499
L+GG +G F+S DHI+ DDVYGG+ RLL +V G++ T +
Sbjct: 62 LEGGSHGFAFSSGLAGIHAIISMFGPEDHILLGDDVYGGSFRLLDKVFVANGLSYTIVNA 121
Query: 500 TNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+++ ++ A+Q NTK +++ETP+NPLLK+ DIEA K+A+
Sbjct: 122 SDLSTIEAAIQPNTKALFLETPSNPLLKITDIEAAAKLAK 161
>UniRef50_A7HF96 Cluster: Cystathionine gamma-synthase; n=7;
Bacteria|Rep: Cystathionine gamma-synthase -
Anaeromyxobacter sp. Fw109-5
Length = 426
Score = 127 bits (307), Expect = 2e-28
Identities = 64/175 (36%), Positives = 93/175 (53%)
Frame = +2
Query: 95 KIGMADHGFLKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGR 274
+ G AD L T +HAG +P+ AV+ PI S+TF + G++Y R
Sbjct: 29 RAGWADRAALVPGAHPGTQCVHAGVQPDP-TYGAVMPPIYQSSTFAFRDVCTNAGYDYTR 87
Query: 275 SGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLR 454
SGNPTR LEE L L+GG ++ HG H++ + D YGGT R L
Sbjct: 88 SGNPTRAALEEALTILEGGSGATCTSTGMSAVIVALNLLPHGSHLLCTVDCYGGTFRALE 147
Query: 455 QVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
A G+ T+ D +++ V A + NT+M+WIETP+NPLL++ D+ A+ +AR
Sbjct: 148 HAKAAYGLEVTYLDLADLDSVAAAFRPNTRMVWIETPSNPLLRLTDVAAVAALAR 202
>UniRef50_Q49UL2 Cluster: Cystathionine beta-lyase cystathionine
gamma-synthase; n=16; Staphylococcus|Rep: Cystathionine
beta-lyase cystathionine gamma-synthase - Staphylococcus
saprophyticus subsp. saprophyticus (strain ATCC 15305
/DSM 20229)
Length = 391
Score = 127 bits (306), Expect = 2e-28
Identities = 58/138 (42%), Positives = 82/138 (59%)
Frame = +2
Query: 206 PIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXX 385
P+ S+TF Q ++Y RSGNP R LEE LA L+GG + +AS
Sbjct: 25 PLYDSSTFHQKTLGGGAQYDYARSGNPNRALLEEKLAKLEGGSHAFAYASGIAAISAVLL 84
Query: 386 XXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETP 565
N GDH++ DDVYGGT RL Q++ R I + D T++ +++ A+Q+NTK+I+IETP
Sbjct: 85 TLNAGDHVILPDDVYGGTFRLTEQILTRFNIQFSTIDTTHLNEIEEAIQDNTKLIYIETP 144
Query: 566 TNPLLKVVDIEAIVKIAR 619
+NPL K+ DI IA+
Sbjct: 145 SNPLFKITDIRGAADIAK 162
>UniRef50_Q2IEA5 Cluster: Cystathionine gamma-synthase; n=1;
Anaeromyxobacter dehalogenans 2CP-C|Rep: Cystathionine
gamma-synthase - Anaeromyxobacter dehalogenans (strain
2CP-C)
Length = 426
Score = 126 bits (303), Expect = 6e-28
Identities = 63/174 (36%), Positives = 93/174 (53%)
Frame = +2
Query: 95 KIGMADHGFLKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGR 274
+ G + L G AT +HAG +P+ AV+ PI S+TF + G++Y R
Sbjct: 29 RAGWTERAPLVPGAGLATQCVHAGVQPDP-AYGAVMPPIYQSSTFAFRDVCTNAGYDYTR 87
Query: 275 SGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLR 454
SGNPTR LEE +A L+GG + HG H++ + D YGGT R L
Sbjct: 88 SGNPTRAALEEAIATLEGGAGATCTTTGMAAVLVALNLLPHGSHLLCTVDCYGGTFRTLE 147
Query: 455 QVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
G+ T+ D ++ V+ A++ NT M+WIETP+NPLL++ DI A+ ++A
Sbjct: 148 HARQAYGLEVTYLDLADLGAVERALRPNTGMVWIETPSNPLLRLTDIRAVTELA 201
>UniRef50_P46807 Cluster: Cystathionine gamma-synthase (EC 2.5.1.48)
(CGS) (O-succinylhomoserine (thiol)-lyase); n=42;
cellular organisms|Rep: Cystathionine gamma-synthase (EC
2.5.1.48) (CGS) (O-succinylhomoserine (thiol)-lyase) -
Mycobacterium leprae
Length = 388
Score = 123 bits (296), Expect = 4e-27
Identities = 64/163 (39%), Positives = 93/163 (57%), Gaps = 2/163 (1%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE-HTGFEYGRSGNPTRNTLEECL 313
G AT AIHAG P+ + AV PI S+TF Q E GFEY R+GNP R LE L
Sbjct: 13 GLATKAIHAGYRPDP-ATGAVNVPIYASSTFAQDGVGELRGGFEYARTGNPMRAALEASL 71
Query: 314 AALDGGKYGLTFASXXXXXX-XXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTF 490
A ++ G + F+S GDH++ DDVYGGT RL+ +V + ++ T
Sbjct: 72 ATVEEGVFARAFSSGMAASDCALRVMLRPGDHVIIPDDVYGGTFRLIDKVFTQWNVDYTP 131
Query: 491 TDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
++++ V+ A+ T++IW+ETPTNPLL + DI +I ++ +
Sbjct: 132 VPLSDLDAVRAAITSRTRLIWVETPTNPLLSIADITSIGELGK 174
>UniRef50_Q38DH3 Cluster: Cystathione gamma lyase, putative; n=7;
Trypanosomatidae|Rep: Cystathione gamma lyase, putative
- Trypanosoma brucei
Length = 445
Score = 121 bits (292), Expect = 1e-26
Identities = 64/164 (39%), Positives = 90/164 (54%), Gaps = 3/164 (1%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPA--EHTGFEYGRSGNPTRNTLEEC 310
GF T+ +H G +P+ + AV+TPI STTF Q + + GF Y RS NPT LEE
Sbjct: 59 GFDTLLVHGGVKPDPV-TGAVLTPIYQSTTFVQESIELYQSRGFSYTRSANPTVKALEEK 117
Query: 311 LAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTT 487
L A++ G Y +++ N GDH + +D YGGTNR R R G+ T
Sbjct: 118 LCAVEKGDYATVYSTGMAATTTVVSALMNAGDHAIVTDCSYGGTNRACRVFFTRFGMEFT 177
Query: 488 FTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
F D ++ V+ A++ NTK++ ETP NP L + DI A+ KI +
Sbjct: 178 FVDMRDLSNVEKAIKSNTKLVISETPANPTLTLTDIRALSKICK 221
>UniRef50_P53780 Cluster: Cystathionine beta-lyase, chloroplast
precursor; n=11; cellular organisms|Rep: Cystathionine
beta-lyase, chloroplast precursor - Arabidopsis thaliana
(Mouse-ear cress)
Length = 464
Score = 120 bits (289), Expect = 3e-26
Identities = 58/165 (35%), Positives = 97/165 (58%)
Frame = +2
Query: 122 LKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTL 301
+K++ +T+ ++ + + ++ A+ TP+ + TFKQP+ E+ ++Y RSGNPTR+ L
Sbjct: 81 IKEEASVSTLLVNLDNKFDPFD--AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDAL 138
Query: 302 EECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGIN 481
E LA LD F S +G+ IV+ DDVYGG++RLL QV+ R G+
Sbjct: 139 ESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVV 198
Query: 482 TTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+ T +++V A+ TK++W+E+PTNP ++ DI I ++A
Sbjct: 199 VKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMA 243
>UniRef50_A6X770 Cluster: Cystathionine gamma-synthase; n=1;
Ochrobactrum anthropi ATCC 49188|Rep: Cystathionine
gamma-synthase - Ochrobactrum anthropi (strain ATCC
49188 / DSM 6882 / NCTC 12168)
Length = 398
Score = 120 bits (288), Expect = 4e-26
Identities = 61/167 (36%), Positives = 90/167 (53%), Gaps = 2/167 (1%)
Frame = +2
Query: 125 KQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLE 304
+ + GFAT AIH GQEP+ + AV+ PI +TT+ Q G++Y RSGNPTRN LE
Sbjct: 7 RNQAGFATRAIHVGQEPDPL-TGAVIPPIYHATTYVQDGIGASKGYDYTRSGNPTRNGLE 65
Query: 305 ECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQV-IARLGIN 481
CLA L+G F S G I++ +D+YGG RLL V N
Sbjct: 66 RCLADLEGAAAAFVFPSGLAAAATLLEALPAGSSILAHNDLYGGVYRLLADVRPVTAAHN 125
Query: 482 TTFTDFTNIEKVKNA-MQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
F DF++ ++ A + ++W ETP+NP L++VD+ + ++ +
Sbjct: 126 VNFVDFSDEAALRQAVLDHKPALLWFETPSNPTLRIVDLSLVAELGK 172
>UniRef50_A3HJ37 Cluster: Cystathionine gamma-lyase; n=7;
Gammaproteobacteria|Rep: Cystathionine gamma-lyase -
Pseudomonas putida (strain GB-1)
Length = 400
Score = 114 bits (275), Expect = 1e-24
Identities = 61/168 (36%), Positives = 98/168 (58%), Gaps = 2/168 (1%)
Frame = +2
Query: 122 LKQKP-GFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNT 298
+ +KP FAT IHAG++ ++A + IVT+++F + + + + Y R GNPTR+
Sbjct: 12 MSEKPRNFATRTIHAGEQFSVADNA-IFPAIVTASSFTKRSLDDKPEYSYSRVGNPTRHA 70
Query: 299 LEECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARL-G 475
E C+AAL+ G + AS H+V + VYGGT R++ +R G
Sbjct: 71 YETCVAALEEGVGAVACASGVNATATVLELLPKDAHVVVMNGVYGGTFRIMEDYRSRTSG 130
Query: 476 INTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ TT+ D ++E V A++ T++IWIE+PTNPLL +VDI+A+ +A+
Sbjct: 131 LTTTYVDLNDLEAVAAAIKPQTQLIWIESPTNPLLHLVDIKAVCDLAK 178
>UniRef50_A5GJ98 Cluster: MetC/metB Cystathionine
beta-lyase/cystathioninegamma-synthase; n=21;
Cyanobacteria|Rep: MetC/metB Cystathionine
beta-lyase/cystathioninegamma-synthase - Synechococcus
sp. (strain WH7803)
Length = 393
Score = 113 bits (273), Expect = 2e-24
Identities = 58/162 (35%), Positives = 87/162 (53%)
Frame = +2
Query: 134 PGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECL 313
P AT+AIH G+ + V+ PI ++TF P GF+Y RSGNP LE L
Sbjct: 16 PADATLAIHHGESFAD-GTGTVMPPIYATSTFAHGNPG---GFDYTRSGNPNFRILEGVL 71
Query: 314 AALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFT 493
A+++ + F S GD ++ +++YG T RL QV A+ G+ T +
Sbjct: 72 ASVERCDHATVFGSGVSAITAIASTLQQGDLVLCEENLYGCTVRLFEQVFAKFGVRTEWV 131
Query: 494 DFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
DFT+ + ++ M+W+E+PTNPLLKV+D+EA+ AR
Sbjct: 132 DFTDPSALTAIVERQPAMVWLESPTNPLLKVIDLEAVCSAAR 173
>UniRef50_Q8XNZ9 Cluster: Cystathionine gamma-synthase; n=7;
Bacteria|Rep: Cystathionine gamma-synthase - Clostridium
perfringens
Length = 384
Score = 113 bits (272), Expect = 3e-24
Identities = 58/152 (38%), Positives = 94/152 (61%), Gaps = 1/152 (0%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALD 325
++ IH G ++ + AV PI ++T+KQ + E++G+EY R+GNPTR +LE+ +A ++
Sbjct: 5 SLLIHGGISIDE-KTGAVNIPIYQTSTYKQRSFGENSGYEYSRTGNPTRESLEKLIADIE 63
Query: 326 GGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGIN-TTFTDFT 502
GK G FAS GD ++ ++++YGGT R++ ++ + GI DFT
Sbjct: 64 YGKRGFAFASGLAAITAVLSLFKSGDKLLITNNLYGGTFRVIDKIFSNFGIGYEIIDDFT 123
Query: 503 NIEKVKNAMQENTKMIWIETPTNPLLKVVDIE 598
NIE+ + ++ K I+IETPTNPLL V+DI+
Sbjct: 124 NIEE---KIDKSVKAIYIETPTNPLLDVIDIK 152
>UniRef50_Q8KNG3 Cluster: CalE6; n=2; Micromonosporaceae|Rep: CalE6
- Micromonospora echinospora (Micromonospora purpurea)
Length = 381
Score = 112 bits (270), Expect = 6e-24
Identities = 63/160 (39%), Positives = 86/160 (53%), Gaps = 1/160 (0%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAA 319
F T +H G+ P + VV PI STT+++ A E F YGR NPTR LEECLA
Sbjct: 6 FDTRLVHGGRRPSA-GTGDVVPPIHVSTTYERRAQDEPRYF-YGRGENPTREELEECLAG 63
Query: 320 LDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDF 499
L+ + F+S G +VS+DDVY GT+ L + AR G+ + D
Sbjct: 64 LERAPFATVFSSGQAAAATLLSLVRPGQCVVSTDDVYAGTDGLF-DLAARQGVRVRYADL 122
Query: 500 TNIEKVKNAMQE-NTKMIWIETPTNPLLKVVDIEAIVKIA 616
T E + A+ E + ++WIETPTNPLL VVD+ + + A
Sbjct: 123 TTPEGIAAALAEPDLALVWIETPTNPLLTVVDVAEVSRRA 162
>UniRef50_A5E0C2 Cluster: Cystathionine gamma-lyase; n=6; cellular
organisms|Rep: Cystathionine gamma-lyase - Lodderomyces
elongisporus (Yeast) (Saccharomyces elongisporus)
Length = 406
Score = 112 bits (270), Expect = 6e-24
Identities = 58/160 (36%), Positives = 88/160 (55%), Gaps = 2/160 (1%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTG-FEYGRSGNPTRNTLEECLA 316
F T A+H G P + AV+ PI STTF Q P++ G +EY RS NP R+ E+ +A
Sbjct: 11 FGTRAVHVGA-PIDATTGAVIEPISLSTTFGQSEPSKPLGIYEYSRSANPNRDNFEQAVA 69
Query: 317 ALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTD 496
+L+ KY + +S G HI+S DVYGGT+R +V G+ F
Sbjct: 70 SLEQAKYAIALSSGSATTALIIQSLPIGSHIISGGDVYGGTHRYFTKVANHHGVEAQFV- 128
Query: 497 FTNI-EKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
N+ + ++ ++ TK++W+ETP+NP L+V DI + +I
Sbjct: 129 -ANLADDLEATLRPETKLVWVETPSNPTLQVTDIAKVKQI 167
>UniRef50_Q5MQ31 Cluster: L-methionine-gamma-lyase; n=3;
Micrococcineae|Rep: L-methionine-gamma-lyase -
Brevibacterium linens
Length = 425
Score = 110 bits (265), Expect = 2e-23
Identities = 56/162 (34%), Positives = 85/162 (52%), Gaps = 2/162 (1%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE-HTGFEYGRSGNPTRNTLEECL 313
G +T ++H+G PE ++ +VV PI ++TF P + GF+Y R+G P R+ LE+ L
Sbjct: 7 GISTRSVHSGANPES-HTGSVVAPIFQTSTFMMDTPGQTRAGFDYARTGTPNRSDLEDVL 65
Query: 314 AALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTF 490
L+ + S GD I+ D+YGGT RLL+ R GI+
Sbjct: 66 CELENASFAAAVNSGTSAEVAVFSALLGPGDEIIIPRDIYGGTYRLLKNEYERWGISIRT 125
Query: 491 TDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
D T+ E + A+ T ++W+ETP+NP L +VDI K+A
Sbjct: 126 VDLTDTEALAAAISAKTAIVWVETPSNPGLDIVDIAETAKLA 167
>UniRef50_Q1IQ68 Cluster: Cystathionine gamma-synthase; n=1;
Acidobacteria bacterium Ellin345|Rep: Cystathionine
gamma-synthase - Acidobacteria bacterium (strain
Ellin345)
Length = 400
Score = 108 bits (260), Expect = 9e-23
Identities = 54/160 (33%), Positives = 91/160 (56%), Gaps = 1/160 (0%)
Frame = +2
Query: 143 ATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAAL 322
+T+AI G+ + ++++++ P+ ++TF A GF Y R NPT + LE+ + L
Sbjct: 9 STLAIRGGRSLDS-HASSILFPLYQTSTFVHDAVGVDKGFSYSRVSNPTVDALEKAIGVL 67
Query: 323 DGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDF 499
+G + F + GDH V S+ +YGGT RL R+++ LGI +F D
Sbjct: 68 EGTPPAVCFRTGMAAVTTLFLSVLRAGDHAVLSEVIYGGTMRLFREILDHLGITASFVDT 127
Query: 500 TNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
++ V+ A++ TK+I+IETP NP LK+ DI A+ ++A+
Sbjct: 128 SDAANVERAIRPETKIIFIETPGNPTLKLTDIAAVAEVAK 167
>UniRef50_Q4QFT8 Cluster: Cystathionine beta-lyase-like protein;
n=4; Eukaryota|Rep: Cystathionine beta-lyase-like
protein - Leishmania major
Length = 459
Score = 108 bits (260), Expect = 9e-23
Identities = 53/139 (38%), Positives = 80/139 (57%), Gaps = 2/139 (1%)
Frame = +2
Query: 206 PIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXX 385
PI + TF QP E ++Y RSGNPTR +E +A L+G F+S
Sbjct: 84 PIYQTATFVQPDIEEFGPYDYSRSGNPTRTAIETLVANLEGAHAAFAFSSGMAALQTLVT 143
Query: 386 XXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQEN--TKMIWIE 559
N GD I++S D+YGG +RLL Q+ + LG+ F + E V+ A+ +N K++ +E
Sbjct: 144 TLNAGDTILASSDLYGGMHRLLTQITSCLGMTVVFVPMWDTEAVRQALVDNPAAKLLHME 203
Query: 560 TPTNPLLKVVDIEAIVKIA 616
+PTNPL+++VDI A+ + A
Sbjct: 204 SPTNPLMRIVDIRAVCEAA 222
>UniRef50_Q8R9N2 Cluster: Cystathionine beta-lyases/cystathionine
gamma-synthases; n=4; Bacteria|Rep: Cystathionine
beta-lyases/cystathionine gamma-synthases -
Thermoanaerobacter tengcongensis
Length = 393
Score = 107 bits (258), Expect = 2e-22
Identities = 51/121 (42%), Positives = 75/121 (61%), Gaps = 1/121 (0%)
Frame = +2
Query: 260 FEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGG 436
+ Y R GNP + +EE +A L+G + G AS N GDHI+++ D+YGG
Sbjct: 54 YMYTRLGNPNQTAVEELIANLEGAEAGQACASGMAAISSALLAEVNSGDHIIAAKDIYGG 113
Query: 437 TNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
TN L RLGI + DF+++E V+ A++ NTK+I++E TNPL++V DIE +VKIA
Sbjct: 114 TNSLFNLEFKRLGIEISLVDFSDLESVEKAIKPNTKVIYMEIMTNPLIRVFDIEEVVKIA 173
Query: 617 R 619
+
Sbjct: 174 K 174
>UniRef50_Q8TMW7 Cluster: Methionine gamma-lyase; n=3;
Methanosarcina|Rep: Methionine gamma-lyase -
Methanosarcina acetivorans
Length = 406
Score = 107 bits (258), Expect = 2e-22
Identities = 64/171 (37%), Positives = 95/171 (55%), Gaps = 11/171 (6%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTF-----KQPAP---AEHTGFEYGR--SGNPT 289
FAT +HAG+EP+ A TPI ++TF +Q A E +G+ Y R PT
Sbjct: 7 FATKCVHAGEEPDPVFGAHT-TPIFQTSTFIFKNVEQGAARFAGEESGYVYTRIPPNTPT 65
Query: 290 RNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIA 466
L E +A L+GG+ G TFAS GDH++S+D VYG T L +++
Sbjct: 66 HAVLAEKVAVLEGGEAGQTFASGMAAITAVVLSTLKQGDHLISTDVVYGCTYSLFSEILP 125
Query: 467 RLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
GI+ +F D ++I+KV+ A + T+M+++ETP NP + V DI I K+A+
Sbjct: 126 GFGIDVSFVDTSDIKKVRAAFKPETRMVFLETPANPTITVCDIREISKLAK 176
>UniRef50_Q9KCE4 Cluster: Cystathionine gamma-synthase
(O-succinylhomoserine (Thiol)-lyase); n=44;
Bacteria|Rep: Cystathionine gamma-synthase
(O-succinylhomoserine (Thiol)-lyase) - Bacillus
halodurans
Length = 378
Score = 107 bits (256), Expect = 3e-22
Identities = 48/143 (33%), Positives = 80/143 (55%)
Frame = +2
Query: 188 SAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXX 367
+ A+ TP+ ST ++ E TG++Y R+GNPTR LE+ +A L+ G G +S
Sbjct: 21 TGAINTPVYFSTAYRHSGIGESTGYDYARTGNPTREVLEKAIATLENGDQGFACSSGMAA 80
Query: 368 XXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKM 547
GD I++S D+YGGT RL + G++ ++ D N+ ++ + E T+
Sbjct: 81 IQTVFSLFQSGDEIIASQDLYGGTYRLFEGGWKKWGLSFSYADPRNLAALEQQITEKTRA 140
Query: 548 IWIETPTNPLLKVVDIEAIVKIA 616
++IETPTNPL++ +I + +A
Sbjct: 141 LFIETPTNPLMQEANIRELAALA 163
>UniRef50_Q0LLX7 Cluster: Cystathionine gamma-synthase; n=3;
Bacteria|Rep: Cystathionine gamma-synthase -
Herpetosiphon aurantiacus ATCC 23779
Length = 372
Score = 107 bits (256), Expect = 3e-22
Identities = 58/158 (36%), Positives = 86/158 (54%), Gaps = 1/158 (0%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHT-GFEYGRSGNPTRNTLEECLAAL 322
T+ IHAG+ + SA V PI ++TF++ A GF Y R GNPTR LE+ LAAL
Sbjct: 5 TLLIHAGRSVDAATSA-VTPPIHLASTFERAADGSLPHGFVYTRFGNPTRQALEQALAAL 63
Query: 323 DGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFT 502
+GG F S G ++ D Y GT L+RQV A+L + F D T
Sbjct: 64 EGGVEAAAFGSGSAATTAVLQSLAPGQRVLLPRDCYNGTANLVRQVFAQL--DAQFVDMT 121
Query: 503 NIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
++ V+ A++ ++W+ETP+NP L++ D+ A+ +A
Sbjct: 122 DLAAVQAALEPAPALVWLETPSNPTLRLTDLAAVSNLA 159
>UniRef50_A0NJV2 Cluster: O-succinylhomoserine thiol-lyase; n=2;
Leuconostocaceae|Rep: O-succinylhomoserine thiol-lyase -
Oenococcus oeni ATCC BAA-1163
Length = 369
Score = 106 bits (255), Expect = 4e-22
Identities = 52/154 (33%), Positives = 82/154 (53%), Gaps = 1/154 (0%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALD 325
TI G + + AVV PI ST F+ P E TGF+Y R PTR LE+ LA ++
Sbjct: 6 TILDQGGNGSDDQKTGAVVAPIYFSTAFRHPGLGESTGFDYARLQTPTRQILEKQLAEIE 65
Query: 326 GGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFT 502
G +S GD+ ++SDD+YGG+ R ++ + GI+ + D T
Sbjct: 66 YGDNAFAVSSGMAAIDLLFSTFLKKGDNFIASDDLYGGSFRYFDDLVEKNGIDYSLWDGT 125
Query: 503 NIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAI 604
+ +K + T++IW+ETP+NP +K++DI+ +
Sbjct: 126 DFSYLKQKISPKTRLIWLETPSNPTMKIIDIKKV 159
>UniRef50_Q96VU8 Cluster: Cystathionine beta-lyase; n=3;
Pezizomycotina|Rep: Cystathionine beta-lyase -
Neurospora crassa
Length = 457
Score = 105 bits (253), Expect = 6e-22
Identities = 53/136 (38%), Positives = 74/136 (54%)
Frame = +2
Query: 206 PIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXX 385
PI S TFKQ + + ++Y RSGNPTR LE LA + L+ +S
Sbjct: 64 PIYQSATFKQSSSNGGSEYDYTRSGNPTRTHLERHLAKIMNANRCLSVSSGMGALDVITR 123
Query: 386 XXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETP 565
GD +++ DD+YGGTNRLL + G+ D TN+E V+ + T M+ +ETP
Sbjct: 124 LLKPGDEVITGDDLYGGTNRLLTYLKNNQGVIVHHVDTTNVESVRQIISPKTTMVLLETP 183
Query: 566 TNPLLKVVDIEAIVKI 613
TNPL+K+ DI I +I
Sbjct: 184 TNPLIKICDIPTIARI 199
>UniRef50_Q89V23 Cluster: O-acetylhomoserine sulfhydrylase; n=13;
Bacteria|Rep: O-acetylhomoserine sulfhydrylase -
Bradyrhizobium japonicum
Length = 431
Score = 105 bits (252), Expect = 9e-22
Identities = 66/170 (38%), Positives = 90/170 (52%), Gaps = 9/170 (5%)
Frame = +2
Query: 134 PGFATIAIHAGQEPEKWNSAAVVTPIVTSTTF----KQPAPA----EHTGFEYGRSGNPT 289
P F T+++HAGQ P+ A V PI +T++ A A E G Y R NPT
Sbjct: 7 PAFETLSLHAGQHPDPATGARAV-PIYQTTSYVFQDSDHAAALFNLERAGHIYTRISNPT 65
Query: 290 RNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIA 466
LEE LAAL+GG + AS N GDHIV+S +YGGT LL +
Sbjct: 66 TGVLEERLAALEGGVGAICTASGMAALHLAIATLLNAGDHIVASSSLYGGTINLLAHTLP 125
Query: 467 RLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
R GI TTF +++ ++A++ NTK++ ET NP L+V+DI + IA
Sbjct: 126 RFGITTTFVKPRDLDAFRSAIKPNTKLVIGETIGNPGLEVLDIPKVAAIA 175
>UniRef50_Q2AGF7 Cluster: O-acetylhomoserine/O-acetylserine
sulfhydrylase; n=1; Halothermothrix orenii H 168|Rep:
O-acetylhomoserine/O-acetylserine sulfhydrylase -
Halothermothrix orenii H 168
Length = 397
Score = 105 bits (251), Expect = 1e-21
Identities = 59/174 (33%), Positives = 94/174 (54%), Gaps = 10/174 (5%)
Frame = +2
Query: 125 KQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHT---------GFEYGRS 277
K++ GF T+A+H G +P + S + PI +T++ + AEH G+ Y R
Sbjct: 6 KKQYGFNTLALHHGYDPVQEGSKSRAVPIYQTTSYMFDS-AEHAAGLFAEEEEGYIYTRI 64
Query: 278 GNPTRNTLEECLAALDGGKYGL-TFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLR 454
GNPT EE +A L+GG+ GL T + + G+ +VSS +YGGT LL
Sbjct: 65 GNPTTKVFEERMAVLEGGEAGLATSSGQSAITLTILTLVSQGEEVVSSSYIYGGTYHLLA 124
Query: 455 QVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+ + R G+ T F +I + A+ + T++ ++E+P NP L +VDIEA+ +A
Sbjct: 125 ESLPRYGVKTRFVKPDDINDWEQAITDKTRVFYLESPGNPRLNIVDIEAVSSLA 178
>UniRef50_A7H124 Cluster: Methionine gamma-lyase; n=2;
Campylobacter|Rep: Methionine gamma-lyase -
Campylobacter curvus 525.92
Length = 380
Score = 105 bits (251), Expect = 1e-21
Identities = 54/141 (38%), Positives = 77/141 (54%)
Frame = +2
Query: 194 AVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXX 373
AVV PIV S+TF Q E F Y RS NPT+ EE A +G KY AS
Sbjct: 20 AVVPPIVLSSTFAQEGLGEFGEFAYSRSANPTKKAFEELFAKFEGSKYSFALASGMAATT 79
Query: 374 XXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIW 553
GD ++ +++VYGGT R + GI+ D N+ + ++ + ++ KM++
Sbjct: 80 AVFNLLKSGDKVLLNNNVYGGTYRYASGIFKNQGISYELVDDLNLIE-EDDITDDVKMVF 138
Query: 554 IETPTNPLLKVVDIEAIVKIA 616
IETP+NPLL+V DI+ IV +A
Sbjct: 139 IETPSNPLLRVTDIKRIVNLA 159
>UniRef50_A1HQW4 Cluster: Cystathionine gamma-synthase; n=1;
Thermosinus carboxydivorans Nor1|Rep: Cystathionine
gamma-synthase - Thermosinus carboxydivorans Nor1
Length = 392
Score = 105 bits (251), Expect = 1e-21
Identities = 58/167 (34%), Positives = 89/167 (53%), Gaps = 8/167 (4%)
Frame = +2
Query: 143 ATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHT--------GFEYGRSGNPTRNT 298
+T+A+HAG + V PIV S+ + + A+ GF Y R NPT
Sbjct: 7 STLAVHAGTASPASATEPKVLPIVASSVWSFDSLAQLDDVYENKVPGFVYSRISNPTVEL 66
Query: 299 LEECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGI 478
LE+ + L+GG + GDHIV+ +YGGT LL+ +A+LG+
Sbjct: 67 LEQAVGMLEGGAAAAYASGMAAIATAIFAEVRQGDHIVAHHVLYGGTYALLKNEMAKLGV 126
Query: 479 NTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
TF D ++ V A++ NTK++++ET NPL++V+DI AIV++AR
Sbjct: 127 EVTFVDCNDLSAVAQAIRPNTKILYLETICNPLMEVLDIPAIVQLAR 173
>UniRef50_A5G8H3 Cluster: O-acetylhomoserine
aminocarboxypropyltransferase; n=3; Geobacter|Rep:
O-acetylhomoserine aminocarboxypropyltransferase -
Geobacter uraniumreducens Rf4
Length = 428
Score = 104 bits (250), Expect = 1e-21
Identities = 63/172 (36%), Positives = 90/172 (52%), Gaps = 9/172 (5%)
Frame = +2
Query: 131 KPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE--------HTGFEYGRSGNP 286
K F T+ IH G EP + A PIV S++F Q E G Y R GNP
Sbjct: 18 KYSFDTLLIHGGLEPGP--AGATTVPIVQSSSFAQATAEELEDIFRGRKVGQVYTRVGNP 75
Query: 287 TRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVI 463
T +LE+ LA L+GG+ + AS GD I++S ++GGT L R +
Sbjct: 76 TTESLEKRLALLEGGQAAIATASGMAAITTAVMTIVRSGDEILASSSLFGGTFSLFRDTL 135
Query: 464 ARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ GI+TTF D T++ V+N + + T+++++ET NP + V DI AI IAR
Sbjct: 136 SGYGISTTFVDPTDLAAVRNGINDRTRLVFVETIGNPKMDVPDIPAIALIAR 187
>UniRef50_Q12L75 Cluster: Methionine gamma-lyase; n=1; Shewanella
denitrificans OS217|Rep: Methionine gamma-lyase -
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 /
DSM 15013)
Length = 390
Score = 103 bits (246), Expect = 5e-21
Identities = 58/168 (34%), Positives = 92/168 (54%), Gaps = 9/168 (5%)
Frame = +2
Query: 143 ATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAP--------AEHTGFEYGRSGNPTRNT 298
AT+AIH G + E + A+VTP+ S TF + G+ Y R GNPT
Sbjct: 8 ATVAIHGGHQREAFG--ALVTPLYQSATFAFETAEQGGARFAGDEPGYIYTRLGNPTTAE 65
Query: 299 LEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLG 475
LE +A L+G AS GDH+++S VYG T L+ ++R G
Sbjct: 66 LERKMALLEGADDAAATASGMAAVSAALLTHLEQGDHLIASKAVYGCTYALITTQLSRYG 125
Query: 476 INTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
I+T+ DF++++ V+ A++ NT++++ ETP NP L+V D++A+ K+A+
Sbjct: 126 ISTSLVDFSDMQAVEAAIKPNTRVLFCETPVNPHLQVFDLDAMAKVAK 173
>UniRef50_A0LLP6 Cluster: Cystathionine gamma-synthase; n=1;
Syntrophobacter fumaroxidans MPOB|Rep: Cystathionine
gamma-synthase - Syntrophobacter fumaroxidans (strain
DSM 10017 / MPOB)
Length = 400
Score = 103 bits (246), Expect = 5e-21
Identities = 60/173 (34%), Positives = 90/173 (52%), Gaps = 9/173 (5%)
Frame = +2
Query: 128 QKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHT--------GFEYGRSGN 283
++ G T AIH G EK + PI ++TF P+ AE G+ Y R N
Sbjct: 9 RRMGKHTKAIHGGGL-EKKVYGEISVPIFQTSTFGFPSAAEGAARFAGESDGYIYTRLNN 67
Query: 284 PTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQV 460
PT N LEE + L+GG + ++ + GDH+V++D +YG + L+
Sbjct: 68 PTANALEEAMTLLEGGFAAIASSTGMAAVTTTLLTFLSQGDHVVATDSIYGASRMALQFE 127
Query: 461 IARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
AR GI TF D ++ ++ A+ NTK+I++ETPTNP + V DI A ++AR
Sbjct: 128 FARFGIGATFVDSSSTANIERAIGRNTKVIFLETPTNPTMAVSDIRAAAELAR 180
>UniRef50_Q0ALD7 Cluster: Cystathionine gamma-synthase; n=2;
Hyphomonadaceae|Rep: Cystathionine gamma-synthase -
Maricaulis maris (strain MCS10)
Length = 382
Score = 101 bits (243), Expect = 1e-20
Identities = 56/160 (35%), Positives = 87/160 (54%), Gaps = 2/160 (1%)
Frame = +2
Query: 146 TIAIHAGQEPEK-WNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAAL 322
T AI AG ++ WN AV+ P+ ST +++ PA F+Y R+GNP R+ L + +A L
Sbjct: 7 TKAIRAGLNTDRSWN--AVIPPLSLSTAYRREDPAIQPAFDYARTGNPGRSLLADAIAEL 64
Query: 323 DGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLG-INTTFTDF 499
+ + S HG ++ S D YGGT RLL R G + + D
Sbjct: 65 ENAAGAIVTGSGMSAIDLLLHDIPHGARVICSHDAYGGTRRLL-DARGRGGRLIPVYVDT 123
Query: 500 TNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
T++EKV +A+ E+ +I ETP+NP L++ DI+ + ++AR
Sbjct: 124 TDLEKVADALNEDAALIIAETPSNPRLRISDIKGLARLAR 163
>UniRef50_A4EYE9 Cluster: Cystathionine beta-lyase/cystathionine
gamma-synthase; n=2; Roseobacter|Rep: Cystathionine
beta-lyase/cystathionine gamma-synthase - Roseobacter
sp. SK209-2-6
Length = 453
Score = 101 bits (242), Expect = 1e-20
Identities = 59/170 (34%), Positives = 94/170 (55%), Gaps = 9/170 (5%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNSAAVVTPIVTSTTF----KQPAPAE----HTGFEYGRSGNPTR 292
G +T A+HAG + + AV TPI ++TF Q E F Y R GNP++
Sbjct: 49 GLSTCAVHAGTHDDP-RTGAVGTPIYQTSTFVLNDDQYESVEGGFARDRFIYSRYGNPSQ 107
Query: 293 NTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIAR 469
++E LAAL+G + + F+S + G H+V++ D+YGGT L Q
Sbjct: 108 WAVQEKLAALEGAESAIVFSSGMAAITAGVLAMVDKGAHVVAASDLYGGTYNLFNQEFPS 167
Query: 470 LGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
G++ T D +++ ++ A+Q NT+ ++ E TNP+LKVV+I A+V+IA+
Sbjct: 168 FGMSATLVDSYDLDAIEEAIQPNTQALYFEAITNPVLKVVNIPALVEIAK 217
>UniRef50_Q5UZS6 Cluster: Cystathionine gamma-synthase; n=3;
cellular organisms|Rep: Cystathionine gamma-synthase -
Haloarcula marismortui (Halobacterium marismortui)
Length = 411
Score = 101 bits (242), Expect = 1e-20
Identities = 49/121 (40%), Positives = 72/121 (59%), Gaps = 2/121 (1%)
Frame = +2
Query: 260 FEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGG 436
F Y R NPTR+ LE+ LAAL+GG+ F+S GDH+V+ DD+Y G
Sbjct: 68 FLYSRLSNPTRHGLEQELAALEGGERAYAFSSGTAAVATAVLSLVEPGDHVVAFDDLYAG 127
Query: 437 TNRLLRQVIA-RLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
T R+ + +LG++ F D T+ + V AM T+++W+ETPTNP +K+ DI+AI +
Sbjct: 128 TRRMFETLFRDQLGVDVEFVDATDADAVAAAMTPATELVWVETPTNPRIKLCDIDAIAAV 187
Query: 614 A 616
A
Sbjct: 188 A 188
>UniRef50_Q65SV6 Cluster: Putative uncharacterized protein; n=1;
Mannheimia succiniciproducens MBEL55E|Rep: Putative
uncharacterized protein - Mannheimia succiniciproducens
(strain MBEL55E)
Length = 332
Score = 100 bits (240), Expect = 2e-20
Identities = 60/170 (35%), Positives = 88/170 (51%), Gaps = 10/170 (5%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPA--------EHTGFEYGRSGNPTRN 295
F T +HAG P+ N V PIV STT+ + + GF Y R NPT N
Sbjct: 34 FETQCLHAGYSPK--NGEPRVQPIVQSTTYTYDSAESIGKLFDLQEAGFFYTRLANPTTN 91
Query: 296 TLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARL 472
EE LAAL+GG L AS GDH +S+ ++YGGT L ++
Sbjct: 92 AAEEKLAALEGGVAALCTASGQAATFYALMNLVESGDHFISTTNIYGGTYNLFAHTFRKM 151
Query: 473 GINTTFTDFT-NIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
G+ TF + N+++++ A++ NTK ++ ET +NP L+V+DIE +A+
Sbjct: 152 GVEVTFVNQDDNLDELRKAIRPNTKAVFGETISNPTLRVLDIEKFAALAQ 201
>UniRef50_Q9KEQ0 Cluster: Methionine gamma lyase; n=13;
Bacillaceae|Rep: Methionine gamma lyase - Bacillus
halodurans
Length = 393
Score = 100 bits (239), Expect = 3e-20
Identities = 56/175 (32%), Positives = 94/175 (53%), Gaps = 9/175 (5%)
Frame = +2
Query: 122 LKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPA--------PAEHTGFEYGRS 277
+K+ F T AIH G +P + + ++ PI ++TF + E G+ Y R
Sbjct: 1 MKRDQHFETRAIHTGYKPNE-HFDSLTPPIYQTSTFTFASMEQGGNRFAGEEAGYVYSRL 59
Query: 278 GNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNHG-DHIVSSDDVYGGTNRLLR 454
GNPT LE+ +A L+GG+ L F S DHI+ S+ VYG T LL
Sbjct: 60 GNPTVQILEQRIAELEGGEAALAFGSGMAAVSAILVGLTKANDHILVSNGVYGCTFGLLT 119
Query: 455 QVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ + I+ TF+ ++E++ +Q+NT I++ETP NP ++++D+E +V++A+
Sbjct: 120 MLKEKYNIDATFSPMDSVEEILANIQDNTTCIYVETPINPTMQLIDLELVVRVAK 174
>UniRef50_Q9K024 Cluster: Cystathionine gamma-synthase; n=4;
Neisseria|Rep: Cystathionine gamma-synthase - Neisseria
meningitidis serogroup B
Length = 385
Score = 100 bits (239), Expect = 3e-20
Identities = 55/162 (33%), Positives = 86/162 (53%), Gaps = 2/162 (1%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAA 319
FAT AIH+ + ++ N A ++ PI ++ F E+ + Y R NPTR LE+ +A
Sbjct: 3 FATKAIHSSYDCDEHNRA-LMPPIYQNSMFALHEIGENVPYRYSRLSNPTRQILEDTVAD 61
Query: 320 LDGGKYGLTFASXXXXXXXX-XXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTD 496
L+ G G F+S GD IV+ D+YGG LL V + G+N F D
Sbjct: 62 LEHGAAGFAFSSGMAGIDAVWRTFLRPGDTIVAVADIYGGAYDLLVDVYQKWGVNVVFAD 121
Query: 497 FTNIEKVKNAMQ-ENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
N + + ++ K++W+ETP+NPLL++VDI+ + A+
Sbjct: 122 LGNPDNLDELLKAHKVKLVWLETPSNPLLRLVDIKVLAAKAK 163
>UniRef50_Q8G436 Cluster: Possible cystathionine gamma lyase; n=3;
Bacteria|Rep: Possible cystathionine gamma lyase -
Bifidobacterium longum
Length = 507
Score = 100 bits (239), Expect = 3e-20
Identities = 63/181 (34%), Positives = 90/181 (49%), Gaps = 10/181 (5%)
Frame = +2
Query: 104 MADHG--FLKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFE---- 265
+ HG F Q GF T+AIH G + + A+ PI + + P +
Sbjct: 102 LVHHGQSFDDQPLGFGTLAIHLGNGVDA-ETGAIRRPITLANAYALPYDPSDINWSSSDV 160
Query: 266 --YGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGG 436
Y R+G+P + LEE LA L+G + + AS N GDH + SD Y
Sbjct: 161 NLYTRNGHPNQRYLEEKLARLEGAEDAVVLASGVAALAATFTTFLNRGDHAIFSDTTYIA 220
Query: 437 TNRLLRQVIA-RLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
RLL Q++ + GI T+ D ++ E V+ A++ NTK++ IETP NP LKV DI I K+
Sbjct: 221 AYRLLNQILPEKYGIETSILDTSDPENVRAALRPNTKLVHIETPANPTLKVSDIATIAKL 280
Query: 614 A 616
A
Sbjct: 281 A 281
>UniRef50_Q67R76 Cluster: Cystathionine gamma-lyase; n=13;
Bacteria|Rep: Cystathionine gamma-lyase -
Symbiobacterium thermophilum
Length = 401
Score = 99 bits (238), Expect = 4e-20
Identities = 59/172 (34%), Positives = 90/172 (52%), Gaps = 9/172 (5%)
Frame = +2
Query: 128 QKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTF-----KQPAP---AEHTGFEYGRSGN 283
++PG AT +HAGQ P+ + A+ PI ++TF +Q A E G+ Y R GN
Sbjct: 5 RQPGLATRCVHAGQRPDPL-TGAISPPIYQTSTFAFASLEQGAARFAGEEPGYIYTRLGN 63
Query: 284 PTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQV 460
PT LE +A L+GG+ + F S GDH++ + +YG T L V
Sbjct: 64 PTVAALEAKIADLEGGEAAVAFGSGMAAIAAVVTALVRAGDHVLFGNPIYGCTYDFLMDV 123
Query: 461 IARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+AR G+ T D +V+ A++ NT+++ ETP NP L++ DI A+ +A
Sbjct: 124 MARFGVEATPVDPARPGQVERAIRPNTRLLLFETPANPTLRLADIRALSDLA 175
>UniRef50_A3U7R8 Cluster: O-acetylhomoserine sulfhydrylase; n=8;
Bacteria|Rep: O-acetylhomoserine sulfhydrylase -
Croceibacter atlanticus HTCC2559
Length = 438
Score = 99.5 bits (237), Expect = 6e-20
Identities = 65/162 (40%), Positives = 86/162 (53%), Gaps = 8/162 (4%)
Frame = +2
Query: 143 ATIAIHAGQEPE-KWNSAAVVTPIVTSTTFKQPAPAEHT------GFEYGRSGNPTRNTL 301
AT A+HAG + N+ AV +S FK A + GF Y R NPT + L
Sbjct: 7 ATKALHAGHDTATNGNTRAVPIYQSSSYVFKDADHAANLFNLSEEGFIYTRINNPTNDIL 66
Query: 302 EECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGI 478
E+ LA ++GG ++ AS GDHIV+S+ +YGGT LL+ + R GI
Sbjct: 67 EKRLADIEGGIAAVSTASGTAAINTTLLTLLKAGDHIVASNSLYGGTYNLLKVTLPRFGI 126
Query: 479 NTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAI 604
TTF D N E K A +ENT+ +IE+ NP L V+DIEAI
Sbjct: 127 TTTFVDPQNPENFKKASKENTRAYFIESLGNPKLDVLDIEAI 168
>UniRef50_P44502 Cluster: Cystathionine gamma-synthase (EC 2.5.1.48)
(CGS) (O-succinylhomoserine (thiol)-lyase); n=14;
Bacteria|Rep: Cystathionine gamma-synthase (EC 2.5.1.48)
(CGS) (O-succinylhomoserine (thiol)-lyase) - Haemophilus
influenzae
Length = 369
Score = 99.1 bits (236), Expect = 7e-20
Identities = 56/167 (33%), Positives = 83/167 (49%), Gaps = 1/167 (0%)
Frame = +2
Query: 122 LKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTL 301
+ Q+ T+ AG ++ + AV PI ST + E TGF+Y R+ NPTR L
Sbjct: 1 MTQQYAIDTLLAQAGNRSDE-RTGAVSAPIFLSTAYGHCGIGESTGFDYTRTKNPTRTVL 59
Query: 302 EECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLR-QVIARLGI 478
EE +A L+ G G F+S D + S DVYGGT RLL +
Sbjct: 60 EETIAKLENGDRGFAFSSGMAAIQVLMTLFTAPDEWIVSSDVYGGTYRLLDFSYKNNNSV 119
Query: 479 NTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ + + ++ A+ NTK I+IETP+NPL++ D+ I K+A+
Sbjct: 120 KPVYVNTASASAIEAAINPNTKAIFIETPSNPLMEECDVVEIAKLAK 166
>UniRef50_P13254 Cluster: Methionine gamma-lyase; n=33; cellular
organisms|Rep: Methionine gamma-lyase - Pseudomonas
putida
Length = 398
Score = 99.1 bits (236), Expect = 7e-20
Identities = 60/178 (33%), Positives = 87/178 (48%), Gaps = 9/178 (5%)
Frame = +2
Query: 113 HGFLKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPA--------PAEHTGFEY 268
HG K PGFAT AIH G +P+ + A+V P+ + TF P E G Y
Sbjct: 2 HGSNKL-PGFATRAIHHGYDPQD-HGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFY 59
Query: 269 GRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXX-XXXNHGDHIVSSDDVYGGTNR 445
R NPT N LE +A+L+GG+ GL AS GD ++ + +YG T
Sbjct: 60 SRISNPTLNLLEARMASLEGGEAGLALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFA 119
Query: 446 LLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
L I G+ D +++ ++ AM T++I+ E+P NP + + DI + KIAR
Sbjct: 120 FLHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAGVAKIAR 177
>UniRef50_A6YH84 Cluster: Cystathionine gamma-synthase; n=2;
Lactobacillus casei|Rep: Cystathionine gamma-synthase -
Lactobacillus casei
Length = 378
Score = 98.7 bits (235), Expect = 1e-19
Identities = 53/160 (33%), Positives = 84/160 (52%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAA 319
F T +H G + + + A+V P+ S ++ + ++Y RS NPTR+ LE +A
Sbjct: 4 FNTKLVH-GPQLQTDKAGAIVPPVYQSAMYRFAPDGGTSDWDYARSSNPTRDYLERQIAT 62
Query: 320 LDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDF 499
L+ G G F+S G H + D +Y GT+RLL Q A+ G+ T D
Sbjct: 63 LENGDAGFAFSSGVAAIATVLAIFPDGSHFIIGDSLYSGTDRLLNQYFAQHGLTFTPVDP 122
Query: 500 TNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
++ V+ A++ TK I+ ET +NPLLKV ++AI +A+
Sbjct: 123 RDLTAVEAAIRPETKAIFFETFSNPLLKVSSVKAISTLAK 162
>UniRef50_A1ZDN6 Cluster: Cystathionine beta-lyase; n=1; Microscilla
marina ATCC 23134|Rep: Cystathionine beta-lyase -
Microscilla marina ATCC 23134
Length = 380
Score = 98.7 bits (235), Expect = 1e-19
Identities = 56/159 (35%), Positives = 87/159 (54%), Gaps = 1/159 (0%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALD 325
T+ +H G ++ + +PI TS++F+ T Y + P + ++ + LAAL+
Sbjct: 9 TLCVHTGTYHDQ-AQPGINSPIYTSSSFEYLDTDARTYPRYFNT--PNQESVVKKLAALE 65
Query: 326 GGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFT 502
G+ G+ F S DH++ D+YGGT R + R GI +F D T
Sbjct: 66 SGEDGIIFGSGMAAISTTLLALLKKEDHVLFQADLYGGTQRFITTDFPRFGIEYSFGDAT 125
Query: 503 NIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
NIE + A+Q NTK+I+IETP+NPLL++ DIE IV +A+
Sbjct: 126 NIEMFEEAIQFNTKLIYIETPSNPLLRLTDIEKIVALAK 164
>UniRef50_O94350 Cluster: Cystathionine beta-lyase; n=27; cellular
organisms|Rep: Cystathionine beta-lyase -
Schizosaccharomyces pombe (Fission yeast)
Length = 390
Score = 98.7 bits (235), Expect = 1e-19
Identities = 55/159 (34%), Positives = 87/159 (54%), Gaps = 1/159 (0%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTG-FEYGRSGNPTRNTLEECLAAL 322
T +H +++++++V PI S TFKQP EH G F+Y RSGNPTR+ L+ LA L
Sbjct: 11 TELVHVEGNEDQYHASSV--PIYQSATFKQPC-LEHMGKFDYTRSGNPTRSVLQVHLAKL 67
Query: 323 DGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFT 502
K+ ++ H+V+ D+YGG++RLL + G D +
Sbjct: 68 MKAKHAFVTSNGMSALDMILRCCKSNSHVVAGHDLYGGSDRLLSFNQRQYGFKVDNVDTS 127
Query: 503 NIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
++ + A++ +T ++ IE+PTNP + + DI AIVKI R
Sbjct: 128 DLAAFEAALRPDTNLVLIESPTNPRISICDIRAIVKITR 166
>UniRef50_Q1J8Q9 Cluster: Cystathionine beta-lyase; n=14;
Bacilli|Rep: Cystathionine beta-lyase - Streptococcus
pyogenes serotype M4 (strain MGAS10750)
Length = 463
Score = 98.3 bits (234), Expect = 1e-19
Identities = 51/158 (32%), Positives = 80/158 (50%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALD 325
T +H +++ AA V TST Y R NPT LE+ LA L+
Sbjct: 89 TTLLHGYTVIDEFTGAASVPIYQTSTFHNSELYCPSQKHLYTRFSNPTTEALEDGLACLE 148
Query: 326 GGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTN 505
Y + +AS GDH++ +VYGGT + ++ I T+F D +
Sbjct: 149 KATYAVAYASGMAAISTVLMLLKAGDHVIFPLEVYGGTCQFATAILPNYQIETSFVDMAD 208
Query: 506 IEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ VK +++ NT+MI++ETP+NPLLK+ DI +V++A+
Sbjct: 209 LATVKASIRPNTRMIYLETPSNPLLKICDISELVQLAK 246
>UniRef50_A0JSB0 Cluster: O-acetylhomoserine/O-acetylserine
sulfhydrylase; n=130; cellular organisms|Rep:
O-acetylhomoserine/O-acetylserine sulfhydrylase -
Arthrobacter sp. (strain FB24)
Length = 444
Score = 96.3 bits (229), Expect = 5e-19
Identities = 63/173 (36%), Positives = 88/173 (50%), Gaps = 9/173 (5%)
Frame = +2
Query: 128 QKPGFATIAIHAGQEPEKWNSAAVVTPI--VTSTTFKQPAPAEHT------GFEYGRSGN 283
+K GF T A+HAG P+ + A V PI TS FK A + G Y R GN
Sbjct: 4 RKFGFRTRALHAGGTPDAEHGARAV-PIYQTTSFVFKDTQDAANLFALQKYGNIYSRIGN 62
Query: 284 PTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNH-GDHIVSSDDVYGGTNRLLRQV 460
PT EE +A+L+GG + +S GDHIV++ +YGGT L
Sbjct: 63 PTVAAFEERIASLEGGIGAVATSSGMAAEFITFAALTQAGDHIVAASQLYGGTVTQLDVT 122
Query: 461 IARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ R G++TTF T+ A++ENTK I++E NP +V D+E + K+AR
Sbjct: 123 LRRFGVDTTFVPGTDPADYAAAVRENTKAIFVEVVANPSSEVQDLEGLAKVAR 175
>UniRef50_Q181I0 Cluster: Methionine gamma-lyase; n=2; Clostridium
difficile|Rep: Methionine gamma-lyase - Clostridium
difficile (strain 630)
Length = 384
Score = 95.9 bits (228), Expect = 7e-19
Identities = 57/165 (34%), Positives = 84/165 (50%), Gaps = 8/165 (4%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHT-------GFEYGRSGNPTRNTLE 304
T IH G + + A+ TPI + TF EH G+ Y R NPT LE
Sbjct: 11 TKIIHWGHSADP-TTGALATPICQTATFAAKT-VEHFEELCMTWGYVYTRECNPTLTELE 68
Query: 305 ECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGIN 481
LA L+ + ++ S GDHIVSSD ++ T + +++++ G+
Sbjct: 69 AKLAMLENAESAISSTSGMGAITSTILALVKSGDHIVSSDGIFSHTKLFMSELLSKFGVE 128
Query: 482 TTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
TF D N + VK AM+ NTK+++IE+P NP L +VDI+ I +IA
Sbjct: 129 VTFVDAVNPQNVKEAMRPNTKIVYIESPLNPSLDLVDIKTIAEIA 173
>UniRef50_Q49UL3 Cluster: Cystathionine beta-lyase cystathionine
gamma-synthase; n=14; Staphylococcus|Rep: Cystathionine
beta-lyase cystathionine gamma-synthase - Staphylococcus
saprophyticus subsp. saprophyticus (strain ATCC 15305
/DSM 20229)
Length = 367
Score = 95.1 bits (226), Expect = 1e-18
Identities = 48/138 (34%), Positives = 75/138 (54%)
Frame = +2
Query: 185 NSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXX 364
++ A+ PI ST ++ P E TG++Y R+ NPTR+ EE A L+ G +S
Sbjct: 15 HTGAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRSAFEEAFAKLEHGTASFATSSGMS 74
Query: 365 XXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTK 544
GD I+ S D+YGGT RL + GI+ + DF N E+V+ ++ E+TK
Sbjct: 75 AIQLICNLFKSGDEILVSFDLYGGTFRLFDFYEQQYGIHFKYVDFLNYEEVEQSITEHTK 134
Query: 545 MIWIETPTNPLLKVVDIE 598
++IE +NP + VD++
Sbjct: 135 ALFIEPISNPQMIEVDVD 152
>UniRef50_A5KK19 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus torques ATCC 27756|Rep: Putative
uncharacterized protein - Ruminococcus torques ATCC
27756
Length = 388
Score = 94.7 bits (225), Expect = 2e-18
Identities = 60/168 (35%), Positives = 84/168 (50%), Gaps = 9/168 (5%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPI--VTSTTFKQPAPA------EHTGFEYGRSGNPTRN 295
F TI +HAGQE + A PI TS F A A + G YGR N T+
Sbjct: 6 FDTIQLHAGQERPDPATDARAVPIYATTSYVFHDCADAAARFGLQAEGNIYGRLTNSTQE 65
Query: 296 TLEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGGTNRLLRQVIARL 472
E+ +AAL+GG L AS +G HIVS +YGG+ LL + L
Sbjct: 66 VFEKRIAALEGGSAALAVASGAAAITYTLQALAQNGGHIVSQKTIYGGSYNLLAHTLPNL 125
Query: 473 GINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
GI +F D ++E V+ A+ E TK ++IET NP + D++A+ ++A
Sbjct: 126 GITASFVDIHDLEAVERAITEQTKALYIETLGNPNCDIPDMDALAELA 173
>UniRef50_Q5K6Y9 Cluster: Cystathionine gamma-lyase, putative; n=1;
Filobasidiella neoformans|Rep: Cystathionine
gamma-lyase, putative - Cryptococcus neoformans
(Filobasidiella neoformans)
Length = 466
Score = 94.3 bits (224), Expect = 2e-18
Identities = 61/183 (33%), Positives = 91/183 (49%), Gaps = 23/183 (12%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAA 319
FAT AIH G EP+ ++ AVV + +TTFKQ + GF+Y RSGNPTR++LE+ L +
Sbjct: 6 FATRAIHIGSEPDP-STGAVVPSLSVATTFKQDGINKTRGFDYSRSGNPTRSSLEQLLTS 64
Query: 320 L------DGGKYGLTFASXXXXXXX---------------XXXXXNHGDHIVSSDDVYGG 436
L D F+S G HI++ +DVYGG
Sbjct: 65 LETAPLSDAQGESFVFSSGSAATAAIAHWVTLTKKEGGAGGADGNGGGGHILAVNDVYGG 124
Query: 437 TNRLLRQVIARLGINTTFTDFTNI--EKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVK 610
T R +V G++ T+ D E ++ A++ +T+++W+E PTNP L V + I
Sbjct: 125 TARYFSRVARPTGLDITYLDMIEAGEEGIRAAIRPDTRLVWLEIPTNPTLLVHPLPLISS 184
Query: 611 IAR 619
I +
Sbjct: 185 IVK 187
>UniRef50_Q5QU17 Cluster: Methionine gamma-lyase; n=29; cellular
organisms|Rep: Methionine gamma-lyase - Idiomarina
loihiensis
Length = 408
Score = 93.5 bits (222), Expect = 4e-18
Identities = 55/163 (33%), Positives = 84/163 (51%), Gaps = 9/163 (5%)
Frame = +2
Query: 143 ATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHT--------GFEYGRSGNPTRNT 298
AT IHAG + + A + P+ ++TF+ + + T G+ Y R GNPT
Sbjct: 15 ATQVIHAGAAHDDPHGA-LTAPLYQTSTFRFSSAEQGTRRFAGEEEGYIYSRLGNPTTAE 73
Query: 299 LEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLG 475
LE +A+L+G + A+ GDHIV SD +YG + L ++ R G
Sbjct: 74 LERRMASLEGYEAAAAAATGMGAIAAATMAFVRSGDHIVVSDAIYGCSFALFSELFERFG 133
Query: 476 INTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAI 604
+ F D N +K ++ENT+++++ETP NP LKVVDIE +
Sbjct: 134 VEADFIDLNNEGLLKETLRENTRLVFLETPANPHLKVVDIEKV 176
>UniRef50_Q97PS4 Cluster: Transulfuration enzyme family protein;
n=25; Lactobacillales|Rep: Transulfuration enzyme family
protein - Streptococcus pneumoniae
Length = 364
Score = 92.3 bits (219), Expect = 8e-18
Identities = 52/157 (33%), Positives = 86/157 (54%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALD 325
TI AG + ++ + A+VTP+ STT++ P TGF+Y R+ NPTR+ EE LAA++
Sbjct: 9 TILAQAGIKSDE-ATGALVTPLHFSTTYQHPEFGRSTGFDYTRTKNPTRSKAEEVLAAIE 67
Query: 326 GGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTN 505
Y L +S G +++ D+YGG+ R QV + T+ +
Sbjct: 68 SADYALATSSGMSAIVLAFSVFPVGSKVLAVRDLYGGSFRWFNQVEQEGHFHFTYAN--T 125
Query: 506 IEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
E++ ++++ +++IETPTNPL+ DIE + K+A
Sbjct: 126 EEELIAELEKDVDVLYIETPTNPLMLEFDIEKLAKLA 162
>UniRef50_A7DB98 Cluster: Cystathionine gamma-synthase; n=2;
Methylobacterium extorquens PA1|Rep: Cystathionine
gamma-synthase - Methylobacterium extorquens PA1
Length = 405
Score = 92.3 bits (219), Expect = 8e-18
Identities = 54/144 (37%), Positives = 76/144 (52%), Gaps = 3/144 (2%)
Frame = +2
Query: 194 AVVTPIVTSTTFKQPAP-AEHTGFEYGRSGNPTRNTLEECLAALDGGKYG-LTFASXXXX 367
AVV P+ STT+ + A A +GF Y R N T E+ +AAL+ + G L F S
Sbjct: 43 AVVPPLHLSTTYLRDADNAYRSGFVYARPDNATTREAEDVIAALERAEAGALLFGSGMAA 102
Query: 368 XXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQE-NTK 544
GDH+++ + +Y G R LRQ RL + F + E V+ A++ T+
Sbjct: 103 AAAVFCALERGDHVIAPEVMYWGLRRWLRQEAPRLDLAVDFVPMDDPEAVRAAIRPGKTR 162
Query: 545 MIWIETPTNPLLKVVDIEAIVKIA 616
++WIETP NPL V DI IV+IA
Sbjct: 163 LVWIETPGNPLCTVADIARIVEIA 186
>UniRef50_Q89XR2 Cluster: O-acetylhomoserine sulfhydrylase; n=24;
cellular organisms|Rep: O-acetylhomoserine sulfhydrylase
- Bradyrhizobium japonicum
Length = 433
Score = 91.5 bits (217), Expect = 1e-17
Identities = 58/166 (34%), Positives = 82/166 (49%), Gaps = 9/166 (5%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAP--------AEHTGFEYGRSGNPTRNTL 301
TIAIHAG EPE + AV PI + + + E GF Y R NPT L
Sbjct: 5 TIAIHAGYEPEA-TTHAVAVPIYQTAAYAFDSADHGAALFNLEAEGFRYSRIANPTSAVL 63
Query: 302 EECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGGTNRLLRQVIARLGI 478
E+ ++ L+GG L A+ +HG +IVS +YG T+ LL ++ R GI
Sbjct: 64 EKRISQLEGGVGALAVATGQAALHFAFVNVADHGGNIVSVPQLYGTTHTLLSHILPRQGI 123
Query: 479 NTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
F + + ++ + ENT+ ++ ET NP V DIEA+ KIA
Sbjct: 124 TGRFAESDKPDAIEKLIDENTRAVFAETIGNPAGNVCDIEALAKIA 169
>UniRef50_P06106 Cluster: Protein MET17 [Includes:
O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) (OAH
sulfhydrylase) (Homocysteine synthase); O- acetylserine
sulfhydrylase (EC 2.5.1.47) (OAS sulfhydrylase)]; n=107;
cellular organisms|Rep: Protein MET17 [Includes:
O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) (OAH
sulfhydrylase) (Homocysteine synthase); O- acetylserine
sulfhydrylase (EC 2.5.1.47) (OAS sulfhydrylase)] -
Saccharomyces cerevisiae (Baker's yeast)
Length = 444
Score = 91.5 bits (217), Expect = 1e-17
Identities = 60/169 (35%), Positives = 81/169 (47%), Gaps = 10/169 (5%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNS-AAVVTPIVTSTTF--------KQPAPAEHTGFEYGRSGNPTR 292
F T+ +HAGQE N+ + PI +T++ Q E G+ Y R NPT
Sbjct: 5 FDTVQLHAGQENPGDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTS 64
Query: 293 NTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNH-GDHIVSSDDVYGGTNRLLRQVIAR 469
N LEE +AAL+GG L +S H GD+IVS+ +YGGT + R
Sbjct: 65 NVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKR 124
Query: 470 LGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
GI F + N E+ + E TK +++ET NP V D E IV IA
Sbjct: 125 FGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIA 173
>UniRef50_P00935 Cluster: Cystathionine gamma-synthase (EC 2.5.1.48)
(CGS) (O-succinylhomoserine (thiol)-lyase); n=123;
Proteobacteria|Rep: Cystathionine gamma-synthase (EC
2.5.1.48) (CGS) (O-succinylhomoserine (thiol)-lyase) -
Escherichia coli (strain K12)
Length = 386
Score = 91.1 bits (216), Expect = 2e-17
Identities = 54/160 (33%), Positives = 81/160 (50%), Gaps = 1/160 (0%)
Frame = +2
Query: 143 ATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAAL 322
ATIA+ +G ++ VV PI S+T+ E +Y R GNPTR+ ++ LA L
Sbjct: 6 ATIAVRSGLNDDE-QYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAEL 64
Query: 323 DGGKYG-LTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDF 499
+GG LT GD +V+ D YGG+ RL + R F D
Sbjct: 65 EGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQ 124
Query: 500 TNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ + ++ A+ E K++ +E+P+NPLL+VVDI I +AR
Sbjct: 125 GDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAR 164
>UniRef50_A1ID11 Cluster: Cystathionine gamma-synthase; n=1;
Candidatus Desulfococcus oleovorans Hxd3|Rep:
Cystathionine gamma-synthase - Candidatus Desulfococcus
oleovorans Hxd3
Length = 392
Score = 90.2 bits (214), Expect = 3e-17
Identities = 54/169 (31%), Positives = 88/169 (52%), Gaps = 10/169 (5%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNS-AAVVTPIVTSTTF--------KQPAPAEHTGFEYGRSGNPT 289
G +T A+HAG+ ++N +V TPIV ++TF K+ A FEYGR G+PT
Sbjct: 8 GISTKAVHAGEI--RYNEYGSVTTPIVQTSTFIFKNIDEIKKLAVGAVERFEYGRYGHPT 65
Query: 290 RNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIA 466
+ E LA L+G + + F+S GDHI+ +DD Y T + +
Sbjct: 66 QIAAEHKLAFLEGAEDAVLFSSGMSAITTTLFGLLKSGDHIIITDDAYRRTLEFCKACLV 125
Query: 467 RLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
+ I T + E ++ A++ NT++ + E+PTNP L ++D+E ++ I
Sbjct: 126 KFDIECTVVKMCDYEAMEKAIKPNTRLFFSESPTNPYLNIMDLERLIGI 174
>UniRef50_A5WG79 Cluster: O-succinylhomoserine sulfhydrylase; n=6;
Proteobacteria|Rep: O-succinylhomoserine sulfhydrylase -
Psychrobacter sp. PRwf-1
Length = 434
Score = 89.0 bits (211), Expect = 8e-17
Identities = 54/174 (31%), Positives = 91/174 (52%), Gaps = 9/174 (5%)
Frame = +2
Query: 122 LKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE--------HTGFEYGRS 277
L Q G TIA+ AGQ + + PI T++++ + A+ +G Y R
Sbjct: 35 LSQDYGMQTIAVRAGQH--RTDEGEHNEPIFTTSSYVYESAADAAAHFNGSKSGNVYSRH 92
Query: 278 GNPTRNTLEECLAALDGGKYGLTFASXXXXXXXX-XXXXNHGDHIVSSDDVYGGTNRLLR 454
NPT T E LAAL+GG+ + AS GDHIV++ ++G T L
Sbjct: 93 TNPTVRTFERRLAALEGGERAVATASGMGAILTMCLAYLKQGDHIVAAKQLFGSTVGLFN 152
Query: 455 QVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+ + G++ T+ D + + +A++ NT++++ ETP+NPL ++ D++AI +IA
Sbjct: 153 NFMGKFGVSVTYVDCFDNQAWADAIEPNTRLLFCETPSNPLGQIADLQAISEIA 206
>UniRef50_Q9KFD9 Cluster: Cystathionine gamma-synthase; n=3;
Bacillus|Rep: Cystathionine gamma-synthase - Bacillus
halodurans
Length = 381
Score = 88.6 bits (210), Expect = 1e-16
Identities = 43/119 (36%), Positives = 73/119 (61%), Gaps = 1/119 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGL-TFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTN 442
Y R GNP + L + +A+L+ + G+ T A GDH+++++D+YGGT
Sbjct: 54 YTRYGNPNSDDLGKGVASLEQAEDGVATSAGMSAILVALLALLEKGDHLIAANDLYGGTY 113
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+LL + + +LGI+ +F F E VK A+++ TK+++ ET TNPLL+V DI +V++ +
Sbjct: 114 QLLAEELPKLGIDVSFVPFQEREVVKRAIRKETKVLYSETVTNPLLRVEDIHQVVELGK 172
>UniRef50_Q8RI67 Cluster: Cystathionine beta-lyase; n=2;
Bacteria|Rep: Cystathionine beta-lyase - Fusobacterium
nucleatum subsp. nucleatum
Length = 419
Score = 88.2 bits (209), Expect = 1e-16
Identities = 42/124 (33%), Positives = 70/124 (56%), Gaps = 1/124 (0%)
Frame = +2
Query: 248 EHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNH-GDHIVSSDD 424
+ GF Y R+ NP R L E + ++GG+ + +S GDHI+S
Sbjct: 72 DEKGFCYNRNRNPNRTALIELMNYVEGGEDSIGCSSGMAAISSSIIAHTKTGDHILSDKT 131
Query: 425 VYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAI 604
+YG T + +++ + G+ TTF DFTNIE+VK ++ NT +++ ET +NPL+ V +++ +
Sbjct: 132 LYGETLEIFTKILQKYGVETTFVDFTNIEEVKKNIKSNTVILYTETVSNPLIGVPNLKVL 191
Query: 605 VKIA 616
IA
Sbjct: 192 ANIA 195
>UniRef50_Q8G805 Cluster: Cystathionine beta-lyase; n=2;
Bifidobacterium longum|Rep: Cystathionine beta-lyase -
Bifidobacterium longum
Length = 412
Score = 88.2 bits (209), Expect = 1e-16
Identities = 53/151 (35%), Positives = 76/151 (50%), Gaps = 7/151 (4%)
Frame = +2
Query: 185 NSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXX 364
N+ AV PI STT+ ++Y RSGNPTR+ LE+ +A L+ G G FAS
Sbjct: 18 NTGAVNPPIYNSTTYAFEKVDAMPRYDYARSGNPTRDFLEQQIAQLEQGTRGFAFASGLA 77
Query: 365 XXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQEN-- 538
GD IV D++YGG+ L + R GI D +I ++ A++ +
Sbjct: 78 AIHAVLSIFKPGDRIVVGDNIYGGSYSQLNEFFTRWGILVEAVDTQDIAALEAAVKGDRA 137
Query: 539 -----TKMIWIETPTNPLLKVVDIEAIVKIA 616
+ ++ ET TNPLLKV D+ AI +A
Sbjct: 138 NGIVPAQAVYFETLTNPLLKVNDVRAISTVA 168
>UniRef50_Q31RB7 Cluster: O-acetylhomoserine/O-acetylserine
sulfhydrylase; n=3; cellular organisms|Rep:
O-acetylhomoserine/O-acetylserine sulfhydrylase -
Synechococcus sp. (strain PCC 7942) (Anacystis nidulans
R2)
Length = 434
Score = 88.2 bits (209), Expect = 1e-16
Identities = 58/167 (34%), Positives = 85/167 (50%), Gaps = 10/167 (5%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHT---------GFEYGRSGNPTRNT 298
T+A+HAGQ+P+ + V PI +T++ AEH G Y R NPT +
Sbjct: 7 TLALHAGQKPDPTTGSRAV-PIYQTTSYVFE-DAEHAANLFALKAFGNIYTRLMNPTTDV 64
Query: 299 LEECLAALDGGKYGL-TFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLG 475
LE+ LAAL GG + T + + G +I+S+ ++YGGT L R + R G
Sbjct: 65 LEQRLAALHGGTGAVATSSGQAAIFYAIAAITSAGQNIISTTNLYGGTINLFRHTLKRFG 124
Query: 476 INTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
I F D ++ V A+ ENT++++ E+ NP V D EAI IA
Sbjct: 125 IEVRFVDSSDASSVAAAIDENTRLVYTESIGNPKGNVDDFEAIAAIA 171
>UniRef50_A6W1L9 Cluster: Cystathionine gamma-synthase; n=10;
Bacteria|Rep: Cystathionine gamma-synthase - Marinomonas
sp. MWYL1
Length = 405
Score = 87.8 bits (208), Expect = 2e-16
Identities = 49/170 (28%), Positives = 89/170 (52%), Gaps = 9/170 (5%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQP--------APAEHTGFEYGRSGNPTR 292
G T ++ +G++ EK A TPIV S + A GF Y R NPT
Sbjct: 14 GSGTRSVWSGEQ-EKHPYRATQTPIVASAAYGYQDIDEWYDVALGAAPGFIYSRMSNPTV 72
Query: 293 NTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIAR 469
TLE + L+ + + F++ ++G +VS+ D YGGTN++ + + R
Sbjct: 73 ETLEAKICGLENAESAVAFSTGMAAISSVLYTFLSNGCRVVSTKDSYGGTNKVFEEFLPR 132
Query: 470 LGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+G++ T + + E++++ + + ++++ETPTNP LK+VD++ +V A+
Sbjct: 133 MGVSVTLCETHSHEQIEDEIAKGCDVLYLETPTNPTLKIVDVKRLVAAAK 182
>UniRef50_Q7WKX4 Cluster: Cys/Met metabolism PLP-dependent enzyme;
n=23; Proteobacteria|Rep: Cys/Met metabolism
PLP-dependent enzyme - Bordetella bronchiseptica
(Alcaligenes bronchisepticus)
Length = 414
Score = 87.0 bits (206), Expect = 3e-16
Identities = 51/169 (30%), Positives = 84/169 (49%), Gaps = 8/169 (4%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE-------HTGFEYGRSGNPTRN 295
GF T +H+ ++ + AV P+ S+ + E GF Y R G PT
Sbjct: 5 GFTTTIVHSDRD-QSAEHGAVHKPMHPSSEYVYEDARELAAVFQGKAGFTYARQGTPTTT 63
Query: 296 TLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARL 472
LE + ++ GK ++FA+ GDH+VSS V+G TN LL ++ L
Sbjct: 64 ALEARITRMEAGKSTVSFATGMAALAAIFTTLLRRGDHLVSSQYVFGNTNSLLNTLM-EL 122
Query: 473 GINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
G+ T D T++ +V++A++ NT+M++ ET NP +V D+ + + R
Sbjct: 123 GVEVTMVDATDVRQVRDALRPNTRMVFTETIANPGTQVADLAGMGALCR 171
>UniRef50_UPI0000E46EAD Cluster: PREDICTED: similar to methionine
gamma-lyase; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to methionine gamma-lyase -
Strongylocentrotus purpuratus
Length = 364
Score = 85.8 bits (203), Expect = 7e-16
Identities = 40/122 (32%), Positives = 66/122 (54%), Gaps = 1/122 (0%)
Frame = +2
Query: 257 GFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYG 433
G+ YGR GN + + + L+GG L F++ GDH+++ D V+G
Sbjct: 87 GYIYGRYGNHSCDNASHAINILEGGIGALVFSTGMSAITTTVLALIKTGDHVIAPDPVFG 146
Query: 434 GTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
GT + ++ G+ TTF +IE + A+Q NTK+ + ETPTNP L ++D++A +
Sbjct: 147 GTYKFFNSMLMDFGVETTFVPAGDIEAYRKAIQPNTKIFYGETPTNPTLTLLDLKAFADV 206
Query: 614 AR 619
A+
Sbjct: 207 AK 208
>UniRef50_A3VS82 Cluster: Cystathionine gamma-synthase; n=1;
Parvularcula bermudensis HTCC2503|Rep: Cystathionine
gamma-synthase - Parvularcula bermudensis HTCC2503
Length = 392
Score = 85.8 bits (203), Expect = 7e-16
Identities = 52/165 (31%), Positives = 77/165 (46%)
Frame = +2
Query: 125 KQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLE 304
K P T+ AG E A+ P+ S+T+ P + ++YGRS PTR+ LE
Sbjct: 9 KPAPHAETVLAQAGVG-EDCGHGAIAPPLYLSSTYLWDDPDKKPAYDYGRSRTPTRSVLE 67
Query: 305 ECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINT 484
LA L+GG L A+ G IV+ D YGGT RLL +
Sbjct: 68 TLLAELEGGGGALVCATGMAAIGLPLDRLPAGAKIVAPHDCYGGTYRLLAAHADKGRFEV 127
Query: 485 TFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
F D T E ++ A +I++ETP+NPL+++ D+ +A+
Sbjct: 128 RFLDQTTEEALRAARDFAPDLIYLETPSNPLMRITDLSRWTALAK 172
>UniRef50_Q1IZN0 Cluster: Cystathionine gamma-synthase; n=1;
Deinococcus geothermalis DSM 11300|Rep: Cystathionine
gamma-synthase - Deinococcus geothermalis (strain DSM
11300)
Length = 394
Score = 85.4 bits (202), Expect = 1e-15
Identities = 56/166 (33%), Positives = 80/166 (48%), Gaps = 9/166 (5%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQP----APAEHTGFE----YGRSGNPTRNTL 301
T+A AG+E S + PI ST + P TG E Y R+G P TL
Sbjct: 10 TLAARAGEEARPNASVPLAEPIYQSTVYAFPDLDALERSMTGEEASSFYYRNGTPNAGTL 69
Query: 302 EECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGI 478
E LA L+G + L S GDHIV+ VYG T LL + + RLGI
Sbjct: 70 ERVLATLEGTEAALVAGSGMAAISAALLGVLKSGDHIVADARVYGVTYALLAEELPRLGI 129
Query: 479 NTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
T+F D ++ V+ A + T+++ +E+ TNPL+ V D+ + +A
Sbjct: 130 TTSFVDACDLGAVEAAFRPETRVLHVESLTNPLMTVPDVPRLADLA 175
>UniRef50_A5MZA3 Cluster: O-acetyl-L-homoserine
sulfhydrylase-related protein; n=8; Bacteria|Rep:
O-acetyl-L-homoserine sulfhydrylase-related protein -
Clostridium kluyveri DSM 555
Length = 428
Score = 85.4 bits (202), Expect = 1e-15
Identities = 59/168 (35%), Positives = 82/168 (48%), Gaps = 11/168 (6%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPA--------EHTGFEYGRSGNPTRNTL 301
T + AG P V PI+ STTFK E +G+ Y R NPT + +
Sbjct: 8 TKCVQAGYRPGNGEPRQV--PIIQSTTFKYNTSEDMGKLFDLEASGYFYSRLQNPTNDYV 65
Query: 302 EECLAALDGGKYG-LTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGI 478
+ +A ++ G LT + N GDHIV+S +YGGT L+ ++++GI
Sbjct: 66 AQKIADMESGTAAMLTSSGQAANFFALFNICNCGDHIVASSSIYGGTFNLISVTMSKMGI 125
Query: 479 NTTFT--DFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
TTF D T E++ A Q NTK ++ ET NP L V+DIE K A
Sbjct: 126 TTTFVSPDCTE-EELNAAFQTNTKAVFGETIANPALTVLDIEKFAKAA 172
>UniRef50_P55218 Cluster: O-succinylhomoserine sulfhydrylase; n=95;
Proteobacteria|Rep: O-succinylhomoserine sulfhydrylase -
Pseudomonas aeruginosa
Length = 403
Score = 85.4 bits (202), Expect = 1e-15
Identities = 56/168 (33%), Positives = 86/168 (51%), Gaps = 9/168 (5%)
Frame = +2
Query: 140 FATIAIHAGQE--PEKWNSAAVVTPIVTSTTFKQPAPA------EHTGFEYGRSGNPTRN 295
F T+A+ AGQ PE + A+ T +S F+ A A E G Y R NPT
Sbjct: 19 FDTLAVRAGQRRTPEGEHGEALFT--TSSYVFRTAADAAARFAGEVPGNVYSRYTNPTVR 76
Query: 296 TLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARL 472
T EE +AAL+G + + AS + GDH++ S V+G T L + R
Sbjct: 77 TFEERIAALEGAEQAVATASGMSAILALVMSLCSSGDHVLVSRSVFGSTISLFDKYFKRF 136
Query: 473 GINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
GI + +++ + A + NTK+ ++E+P+NPL ++VDI A+ +IA
Sbjct: 137 GIQVDYPPLSDLAAWEAACKPNTKLFFVESPSNPLAELVDIAALAEIA 184
>UniRef50_Q28Q09 Cluster: Cystathionine gamma-synthase; n=7;
Rhodobacterales|Rep: Cystathionine gamma-synthase -
Jannaschia sp. (strain CCS1)
Length = 396
Score = 85.0 bits (201), Expect = 1e-15
Identities = 51/153 (33%), Positives = 76/153 (49%), Gaps = 9/153 (5%)
Frame = +2
Query: 188 SAAVVTPIVTSTTFKQPAPAE-HT-------GFEYGRSGNPTRNTLEECLAALDGGKYGL 343
S AVVTPI S + P+ A H G+ Y R G+P L + L+ GL
Sbjct: 23 SRAVVTPIQPSVVYASPSIATLHAQYEGRAHGYTYAREGHPNAELLARKIDMLEEADGGL 82
Query: 344 TFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVK 520
S GDHIV + +YG + RL+ Q + R GI T+ D T+++ ++
Sbjct: 83 ILGSGMAAVSATILGLLGQGDHIVGGNQLYGRSLRLMHQDLGRFGIATSVADPTDVDAMR 142
Query: 521 NAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
A++ TKMI +E +NP L+V D+ I+ +AR
Sbjct: 143 AALRPETKMILVEVISNPTLRVADMAGIIALAR 175
>UniRef50_O15564 Cluster: Methionine gamma-lyase; n=2; Trichomonas
vaginalis|Rep: Methionine gamma-lyase - Trichomonas
vaginalis
Length = 396
Score = 85.0 bits (201), Expect = 1e-15
Identities = 53/167 (31%), Positives = 84/167 (50%), Gaps = 9/167 (5%)
Frame = +2
Query: 143 ATIAIHAGQEPEKWNSAAVVTPIVTSTTF-----KQPA---PAEHTGFEYGRSGNPTRNT 298
AT IHA P+K A + PI ++TF +Q + +G+ Y R GNPT +
Sbjct: 9 ATACIHAN--PQKDQFGAAIPPIYQTSTFVFDNCQQGGNRFAGQESGYIYTRLGNPTVSN 66
Query: 299 LEECLAALDGGKYGL-TFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLG 475
LE +A L+ + + T + GDH++S + +YG T+ L + + G
Sbjct: 67 LEGKIAFLEKTEACVATSSGMGAIAATVLTILKAGDHLISDECLYGCTHALFEHALTKFG 126
Query: 476 INTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
I F + +VK M+ NTK+++ ETP NP LK++D+E + K A
Sbjct: 127 IQVDFINTAIPGEVKKHMKPNTKIVYFETPANPTLKIIDMERVCKDA 173
>UniRef50_Q67QQ8 Cluster: Cystathionine gamma-lyase; n=1;
Symbiobacterium thermophilum|Rep: Cystathionine
gamma-lyase - Symbiobacterium thermophilum
Length = 395
Score = 84.2 bits (199), Expect = 2e-15
Identities = 53/166 (31%), Positives = 83/166 (50%), Gaps = 8/166 (4%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTST-TFKQPAPA------EHTGFEYGRSGNPTRNTLE 304
T+A HAG +P ++ AA TST F+ A A E + Y R NPT +E
Sbjct: 14 TLAAHAGDDPFRFLGAAAPPIFETSTFVFRTVADALAAFADEQEHYVYTRRRNPTVRVVE 73
Query: 305 ECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGGTNRLLRQVIARLGIN 481
E LAAL+G FAS GDH+V D YG + ++R GI+
Sbjct: 74 EKLAALEGAAECRLFASGMAAISAAILSCVGAGDHVVCVDTAYGPARAFITGYLSRFGIS 133
Query: 482 TTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
T D + + + A++ NT++ ++E+P++ L+K+ D+ A+ +AR
Sbjct: 134 ATLVDGCDPAEWEAAVRPNTRLFYLESPSSGLMKLQDLAAVTALAR 179
>UniRef50_Q1ITX7 Cluster: Cystathionine gamma-lyase; n=1;
Acidobacteria bacterium Ellin345|Rep: Cystathionine
gamma-lyase - Acidobacteria bacterium (strain Ellin345)
Length = 459
Score = 83.4 bits (197), Expect = 4e-15
Identities = 56/182 (30%), Positives = 86/182 (47%), Gaps = 20/182 (10%)
Frame = +2
Query: 128 QKPGFATIAIHAGQEPEKWN-SAAVVTPIVTSTTFKQPAPAEHTG--FE----------- 265
QK T IH KW+ S VV P+ +S TF+ + FE
Sbjct: 24 QKYDLRTRLIHGSMRTPKWDYSHHVVPPLTSSATFRLSSSQRGARGFFEFACDTIDTTRQ 83
Query: 266 -----YGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNH-GDHIVSSDDV 427
Y R PTR LEE LAA + G+ G+ FA+ GD +V+ + +
Sbjct: 84 VPIYIYDRLDEPTRGMLEENLAAAEAGEMGVCFATGMAAISASICALTRAGDQVVAHNTL 143
Query: 428 YGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIV 607
YG T L+ + R G+ T F D N +++ A+ +T++++ ETP NP L+++DI A+
Sbjct: 144 YGCTYSLMTNWLPRQGVATRFVDMRNPKEIAKAINAHTRIVYFETPVNPNLELIDIAAVR 203
Query: 608 KI 613
+I
Sbjct: 204 EI 205
>UniRef50_A6NZI8 Cluster: Putative uncharacterized protein; n=1;
Bacteroides capillosus ATCC 29799|Rep: Putative
uncharacterized protein - Bacteroides capillosus ATCC
29799
Length = 429
Score = 83.4 bits (197), Expect = 4e-15
Identities = 58/167 (34%), Positives = 80/167 (47%), Gaps = 10/167 (5%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPA--------PAEHTGFEYGRSGNPTRNTL 301
T IHAG P + PIV STTF+ E +G+ Y R NPT + +
Sbjct: 10 TNCIHAGYRPGNGEPRNI--PIVQSTTFRYATGEQMGALFDLEASGYFYTRLQNPTNDYV 67
Query: 302 EECLAALDGGKYG-LTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGI 478
+ AL+GG LT + + GDH+V+S +YGGT L + R+GI
Sbjct: 68 AAKICALEGGTAAMLTSSGQAANFYAVFNIASCGDHVVASSAIYGGTYNLFAVTMKRMGI 127
Query: 479 NTTFTDFTNIE-KVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
TF D E +++ A + NTK ++ ET NP L V+DIE K A
Sbjct: 128 EFTFVDPECSEAELEAAFKPNTKAVFGETIANPALTVLDIEKFAKAA 174
>UniRef50_Q9RSD8 Cluster: O-acetylhomoserine
(Thiol)-lyase/O-acetylserine (Thiol)-lyase; n=2;
Deinococcus|Rep: O-acetylhomoserine
(Thiol)-lyase/O-acetylserine (Thiol)-lyase - Deinococcus
radiodurans
Length = 418
Score = 83.0 bits (196), Expect = 5e-15
Identities = 42/121 (34%), Positives = 65/121 (53%), Gaps = 1/121 (0%)
Frame = +2
Query: 257 GFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYG 433
G Y R NPT LEE L L+GG + AS GDH+VSS ++G
Sbjct: 59 GLSYARIQNPTVRALEERLTVLEGGAATVALASGQAASLTAILSVCRAGDHVVSSASLFG 118
Query: 434 GTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
G+ +L ++ +GI T + + E+++ AMQ+NT+++W E +NP V D+EA+ +
Sbjct: 119 GSTGMLTNILPLMGITATLVE-GHPEQIRAAMQDNTRLVWAEMISNPSGAVADVEALAGV 177
Query: 614 A 616
A
Sbjct: 178 A 178
>UniRef50_Q8R9M2 Cluster: Cystathionine beta-lyases/cystathionine
gamma-synthases; n=5; Clostridia|Rep: Cystathionine
beta-lyases/cystathionine gamma-synthases -
Thermoanaerobacter tengcongensis
Length = 394
Score = 83.0 bits (196), Expect = 5e-15
Identities = 50/174 (28%), Positives = 88/174 (50%), Gaps = 9/174 (5%)
Frame = +2
Query: 122 LKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTF--------KQPAPAEHTGFEYGRS 277
+K++ F T AIH G+E +K A+ PI +TTF ++ E + Y R
Sbjct: 1 MKKEFRFDTKAIH-GEELKKNPENALNPPIFQTTTFVFEDLDHVEKVMSFESQDYVYTRG 59
Query: 278 GNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLR 454
NPT E +A L+ GK + F+S D +++ +YG + ++
Sbjct: 60 NNPTLRLFENRMAELEYGKGAVAFSSGMAAISSVLFSLLRPNDKVLAHKTLYGSSYNVIT 119
Query: 455 QVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
++ + G+ D T++E++K ++ + K+I+ ETP+NP L ++DIE + KIA
Sbjct: 120 NLLPKYGVKYKLIDMTSLEELKESLDDTVKVIYFETPSNPDLSIIDIEEVSKIA 173
>UniRef50_Q5NPR0 Cluster: Cystathionine beta-lyases; n=5;
Sphingomonadales|Rep: Cystathionine beta-lyases -
Zymomonas mobilis
Length = 402
Score = 83.0 bits (196), Expect = 5e-15
Identities = 44/125 (35%), Positives = 66/125 (52%), Gaps = 1/125 (0%)
Frame = +2
Query: 248 EHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDD 424
E G Y R +PT LEE LA ++G + T ++ + GDH V
Sbjct: 59 EQEGMIYSRMQSPTVMMLEEKLALIEGAETSRTMSTGMAAMTSVLLSALSAGDHFVIGRV 118
Query: 425 VYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAI 604
+G L ++ R GI T D ++++ K+A+Q NTK+ + ETPTNP L++VDIEA+
Sbjct: 119 AFGSCRWLSDSLLPRFGITATVVDGADVQQWKDAIQPNTKLFFFETPTNPTLELVDIEAV 178
Query: 605 VKIAR 619
IA+
Sbjct: 179 CNIAK 183
>UniRef50_A4FF27 Cluster: Methionine gamma-lyase; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep: Methionine
gamma-lyase - Saccharopolyspora erythraea (strain NRRL
23338)
Length = 396
Score = 83.0 bits (196), Expect = 5e-15
Identities = 40/125 (32%), Positives = 67/125 (53%), Gaps = 1/125 (0%)
Frame = +2
Query: 248 EHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDD 424
E F Y R GNPT + LE+ +A L+GG L AS + GDH+++
Sbjct: 50 EPEAFVYNRYGNPTVDALEKAVAGLEGGAAALAAASGMGAISTVLLGSLSSGDHVIAQRG 109
Query: 425 VYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAI 604
+YG T LL + R G+ T ++E+++ A++ NTK++++ET NP ++ D+ +
Sbjct: 110 LYGATLALLADLAQRWGVEVTHASGHDVEEMRAALRPNTKLLYLETIGNPTTRIADLPGL 169
Query: 605 VKIAR 619
+AR
Sbjct: 170 FAVAR 174
>UniRef50_P55217 Cluster: Cystathionine gamma-synthase, chloroplast
precursor (EC 2.5.1.48) (CGS) (O-succinylhomoserine
(thiol)-lyase); n=30; Viridiplantae|Rep: Cystathionine
gamma-synthase, chloroplast precursor (EC 2.5.1.48)
(CGS) (O-succinylhomoserine (thiol)-lyase) - Arabidopsis
thaliana (Mouse-ear cress)
Length = 563
Score = 83.0 bits (196), Expect = 5e-15
Identities = 57/178 (32%), Positives = 87/178 (48%), Gaps = 11/178 (6%)
Frame = +2
Query: 113 HGFLKQKPGFATIAIHAGQEPEKWN-SAAVVTPIVTSTT--FKQPAPA------EHTGFE 265
H FL ++ +HAG+ + + A+ TP+V ++ FK+ A FE
Sbjct: 169 HSFLSSD---GSLTVHAGERLGRGIVTDAITTPVVNTSAYFFKKTAELIDFKEKRSVSFE 225
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFASXX-XXXXXXXXXXNHGDHIVSSDDVYGGTN 442
YGR GNPT LE+ ++AL+G + L AS G HIV++ D Y T
Sbjct: 226 YGRYGNPTTVVLEDKISALEGAESTLVMASGMCASTVMLLALVPAGGHIVTTTDCYRKTR 285
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQE-NTKMIWIETPTNPLLKVVDIEAIVKI 613
+ + +LGI T D +I ++ A+ E + + E+PTNP L+ VDIE + KI
Sbjct: 286 IFMENFLPKLGITVTVIDPADIAGLEAAVNEFKVSLFFTESPTNPFLRCVDIELVSKI 343
>UniRef50_A7INF9 Cluster: O-acetylhomoserine
aminocarboxypropyltransferase; n=2;
Alphaproteobacteria|Rep: O-acetylhomoserine
aminocarboxypropyltransferase - Xanthobacter sp. (strain
Py2)
Length = 467
Score = 82.6 bits (195), Expect = 7e-15
Identities = 59/172 (34%), Positives = 81/172 (47%), Gaps = 9/172 (5%)
Frame = +2
Query: 131 KPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFK----QPAPA----EHTGFEYGRSGNP 286
+PGFAT+AIHAG +P+ + A TPI +T+F A A + G Y R NP
Sbjct: 11 EPGFATLAIHAGAQPDP-TTGARATPIYQTTSFVFDDVDHAAALFGLQTFGNIYSRITNP 69
Query: 287 TRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVI 463
T LEE +AAL+GG L AS GD ++S +YGG+
Sbjct: 70 TNAVLEERVAALEGGTAALAVASGHAAQHLVFHTLLTPGDEFIASRKLYGGSINQFNHAF 129
Query: 464 ARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
G N + D +I + A+ TK I+ E+ NP V DI AI +A+
Sbjct: 130 KSFGWNVVWADPDDISSFEKAVTPKTKAIFTESIANPGGVVTDIAAISAVAK 181
>UniRef50_Q1VZU8 Cluster: Cystathionine beta-lyase; n=12;
Bacteroidetes|Rep: Cystathionine beta-lyase -
Psychroflexus torquis ATCC 700755
Length = 405
Score = 82.2 bits (194), Expect = 9e-15
Identities = 46/166 (27%), Positives = 81/166 (48%), Gaps = 1/166 (0%)
Frame = +2
Query: 125 KQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLE 304
K + G TI +H+G + AV +P+ ST + Y S P + L
Sbjct: 25 KMQKGLNTICVHSGDVKDTIYKGAV-SPLYMSTAYAYEGLETSIYPRYFNS--PNQYFLA 81
Query: 305 ECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGIN 481
+ +A L+ + L F S GDH++ + +YGGT + + R GI+
Sbjct: 82 KKIAELEHAESALIFGSGMAAITTAMLSVLESGDHVILQNQIYGGTRNFIIEECHRYGIS 141
Query: 482 TTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
F D N+ +++ ++ TK+++IETP+NPLL++ D++ + K A+
Sbjct: 142 FDFIDVNNLTLLESTVKPETKLLYIETPSNPLLEITDLKLVSKFAK 187
>UniRef50_Q5WAZ1 Cluster: Methionine gamma-lyase; n=1; Bacillus
clausii KSM-K16|Rep: Methionine gamma-lyase - Bacillus
clausii (strain KSM-K16)
Length = 402
Score = 81.8 bits (193), Expect = 1e-14
Identities = 53/173 (30%), Positives = 80/173 (46%), Gaps = 10/173 (5%)
Frame = +2
Query: 125 KQKPGFATIAIHAGQEPEKWNSAAVVTP-IVTSTTFKQPAPAE--------HTGFEYGRS 277
K + GF T H G + WN + ++P I ST F+ P +E YGR
Sbjct: 12 KNRLGFQTACTHGG---DHWNKSGHLSPPICQSTAFEFPTTSEGAVRAADIKADEFYGRW 68
Query: 278 GNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLR 454
G+ LE +AAL+ L +S N GDH ++ + Y T L
Sbjct: 69 GSRNERELEALIAALEEADDALCASSGLGAISMITHAFLNPGDHFIAVHNCYSETKILHE 128
Query: 455 QVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
+ +L ++ TF D ++I K A+Q NTK+++ ETP NP L +VDI + +
Sbjct: 129 SLAEQLSVDVTFIDSSDIHHYKQAIQPNTKLVFAETPANPTLSLVDISKVATL 181
>UniRef50_Q7VIG9 Cluster: O-acetylhomoserine (Thiol)-lyase MetY;
n=18; Epsilonproteobacteria|Rep: O-acetylhomoserine
(Thiol)-lyase MetY - Helicobacter hepaticus
Length = 430
Score = 81.4 bits (192), Expect = 2e-14
Identities = 55/168 (32%), Positives = 84/168 (50%), Gaps = 10/168 (5%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFK----QPAPA----EHTGFEYGRSGNPTRNTL 301
T+A+HAG + + +V PI +T + + A A + G Y R NPT + L
Sbjct: 13 TLALHAGYTYDTQRTISV--PIYQNTAYSFESLEQAAARFGLQEIGNIYTRLSNPTTDVL 70
Query: 302 EECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGGTNRLLRQVIARLGI 478
LAA++GG +G+ AS GD+IV S+ +YGGT L + R GI
Sbjct: 71 GARLAAVEGGIFGVPTASGSAAIFYAIVNCAQSGDNIVFSNKIYGGTQTLFVHTLKRFGI 130
Query: 479 NTTFTDFTNIE-KVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
T D NIE +++ + + TK I+ E+ +NP + + D E I IA+
Sbjct: 131 QTKVFDIDNIESSLESVIDDKTKAIFFESISNPQISIADTEKITAIAK 178
>UniRef50_A5WGJ5 Cluster: O-acetylhomoserine/O-acetylserine
sulfhydrylase; n=142; Bacteria|Rep:
O-acetylhomoserine/O-acetylserine sulfhydrylase -
Psychrobacter sp. PRwf-1
Length = 437
Score = 81.4 bits (192), Expect = 2e-14
Identities = 57/175 (32%), Positives = 81/175 (46%), Gaps = 10/175 (5%)
Frame = +2
Query: 122 LKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEH---------TGFEYGR 274
L+ T+AIHAG E + AV PI ++++ +H G Y R
Sbjct: 11 LENNQRLETLAIHAGYSVEP-TTKAVAVPIYHTSSYAFD-DTQHGADLFDLKVAGNIYTR 68
Query: 275 SGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLL 451
NPT LEE +AAL+GG L AS GD+I+++ +YGGT
Sbjct: 69 IMNPTNAVLEERVAALEGGIGALAVASGMAAITYAVQTICEAGDNIIAASTLYGGTYNFF 128
Query: 452 RQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+ R GI F D N + + + E TKM++ E+ NPL ++DIEAI A
Sbjct: 129 AHTLPRQGIEVRFFDHKNPAAIHDLVDEKTKMVFAESIGNPLGNIIDIEAIADAA 183
>UniRef50_Q86D27 Cluster: Methionine gamma-lyase 2; n=3; Entamoeba
histolytica|Rep: Methionine gamma-lyase 2 - Entamoeba
histolytica
Length = 392
Score = 81.4 bits (192), Expect = 2e-14
Identities = 43/120 (35%), Positives = 61/120 (50%), Gaps = 1/120 (0%)
Frame = +2
Query: 257 GFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYG 433
G Y R GNPT EE + +L+GG F S GDH++S D +YG
Sbjct: 53 GHMYSRMGNPTVEYFEELVNSLEGGVGTAAFGSGMGAIHSATMGLLKAGDHLISGDTLYG 112
Query: 434 GTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
T L +G++ +F + + E V A + NTKM+++E+P NP KV DI+ I KI
Sbjct: 113 CTVELFGNRFKDMGVDVSFVNTASDEAVVKAWKPNTKMVYLESPANPTCKVSDIKGIAKI 172
>UniRef50_Q67KY0 Cluster: O-acetylhomoserine sulfhydrylase; n=28;
cellular organisms|Rep: O-acetylhomoserine sulfhydrylase
- Symbiobacterium thermophilum
Length = 435
Score = 81.0 bits (191), Expect = 2e-14
Identities = 55/167 (32%), Positives = 76/167 (45%), Gaps = 9/167 (5%)
Frame = +2
Query: 143 ATIAIHAGQEPEKWNSAAVVTPIVTSTTF--------KQPAPAEHTGFEYGRSGNPTRNT 298
AT+ +HAG +P+ A V PI +T + +Q E G Y R NPT
Sbjct: 15 ATLVVHAGWQPDPLTGAQAV-PIYQTTAYAFQSTEHARQLFSLEAEGNIYTRINNPTTAA 73
Query: 299 LEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLG 475
E +AAL+GG + FAS N GD IV+S +YGGT L + + G
Sbjct: 74 FEARVAALEGGIGAVAFASGHAALAATVLAICNAGDEIVTSSSLYGGTYNLFATTLPKWG 133
Query: 476 INTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
I F D ++ A+ T++I+ E NP L V DI + IA
Sbjct: 134 ITARFVDAHDLAGFHRAITPRTRLIFGEVIGNPRLDVFDIAGVAAIA 180
>UniRef50_Q4AEY8 Cluster: Cystathionine gamma-synthase; n=1;
Chlorobium phaeobacteroides BS1|Rep: Cystathionine
gamma-synthase - Chlorobium phaeobacteroides BS1
Length = 245
Score = 81.0 bits (191), Expect = 2e-14
Identities = 42/168 (25%), Positives = 80/168 (47%), Gaps = 7/168 (4%)
Frame = +2
Query: 131 KPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPA------EHTGFEYGRSGNPTR 292
K F T+AI + ++ +V + +S F + G+ Y R NP
Sbjct: 2 KTHFETLAIRTQLDTSQFKEHSVPIYLTSSYAFDSAEEGAEIFANQRDGYYYSRVANPNS 61
Query: 293 NTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIAR 469
+ L E +A L+G + G++ A+ GDH+++S ++G + L+ ++
Sbjct: 62 DELAEKMALLEGAESGISTATGMAAIFSVFGALLKKGDHLLASSSIFGSSRHLIENILPN 121
Query: 470 LGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
GI F ++ +NA NTKM+++ETP NP L ++D++ + ++
Sbjct: 122 WGIEHEFVGIKDMHAWENAFHPNTKMVFVETPANPTLDLIDLKYLAEL 169
>UniRef50_A4CKV8 Cluster: Cystathionine beta-lyase; n=11;
Bacteroidetes|Rep: Cystathionine beta-lyase -
Robiginitalea biformata HTCC2501
Length = 417
Score = 81.0 bits (191), Expect = 2e-14
Identities = 43/118 (36%), Positives = 65/118 (55%), Gaps = 1/118 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYG-LTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTN 442
Y R +P+ L E LAAL+G + +T + + GDH+VSS +YGGT
Sbjct: 64 YSRHSSPSNLYLGEALAALEGTESANVTASGMGAITAVILQLCSSGDHLVSSRTIYGGTY 123
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
L+ + R I +F D T+ E V A+ + T+MI+ E+ +NPLL+V DI + K+A
Sbjct: 124 AFLKNFLKRFDIAVSFVDITDPEAVAAAITDKTRMIYCESVSNPLLEVADIPTLAKLA 181
>UniRef50_Q8EM13 Cluster: O-acetylhomoserine sulfhydrylase; n=86;
cellular organisms|Rep: O-acetylhomoserine sulfhydrylase
- Oceanobacillus iheyensis
Length = 556
Score = 80.6 bits (190), Expect = 3e-14
Identities = 53/165 (32%), Positives = 79/165 (47%), Gaps = 8/165 (4%)
Frame = +2
Query: 146 TIAIHAGQEPE-KWNSAAVVTPIVTSTTFKQPAPAEHT------GFEYGRSGNPTRNTLE 304
TI +H GQEP+ S AV TS F+ A++ G Y R NPT + E
Sbjct: 11 TILLHGGQEPDPSTGSRAVPIYQTTSYVFRDTEHAQNLFGLAEPGNIYSRIMNPTVDAFE 70
Query: 305 ECLAALDGGKYGL-TFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGIN 481
+ + L+ G + T + GD IV+ ++YGGT L + R GIN
Sbjct: 71 QRITQLEDGIGAVATSSGMAAITLAILNIAGSGDEIVADSNLYGGTFNLFANTLPRYGIN 130
Query: 482 TTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
F D T+ + + +A+ + TK ++ E TNP L V DIE + ++A
Sbjct: 131 VKFVDGTDPQAIDDAITDKTKAVFGEIITNPSLYVFDIEKVSEVA 175
>UniRef50_Q5QWY7 Cluster: Cystathionine gamma-synthase; n=5;
Proteobacteria|Rep: Cystathionine gamma-synthase -
Idiomarina loihiensis
Length = 383
Score = 80.6 bits (190), Expect = 3e-14
Identities = 43/146 (29%), Positives = 73/146 (50%), Gaps = 2/146 (1%)
Frame = +2
Query: 188 SAAVVTPIVTSTTFKQPAPAEH-TGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXX 364
+ ++ P+ TSTT+ + ++ +G Y R+ NPT E+ LA L+ FAS
Sbjct: 23 NGVIIPPVYTSTTYLRDDDNQYRSGRVYSRADNPTYRPAEKLLAELENAADARLFASGMA 82
Query: 365 XXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQE-NT 541
GD +++ +Y + L+ G++ F D TN+ ++++A+ E
Sbjct: 83 AATAVFQALKPGDKVIAPKVMYWALRKWLQTFGVDSGLDVRFVDTTNLNELRDAIAERQP 142
Query: 542 KMIWIETPTNPLLKVVDIEAIVKIAR 619
+IW+ETP NPL V DI A+ +AR
Sbjct: 143 TLIWLETPGNPLWTVTDIAAVADMAR 168
>UniRef50_A7S3X8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 343
Score = 80.6 bits (190), Expect = 3e-14
Identities = 43/120 (35%), Positives = 65/120 (54%), Gaps = 1/120 (0%)
Frame = +2
Query: 257 GFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYG 433
G+ Y R NPT + + L AL+GG L F+S GDH+V+ VY
Sbjct: 53 GYLYSRWNNPTVDAAAQTLNALEGGVGTLLFSSGMAAISTALLSLLKAGDHVVAPKIVYS 112
Query: 434 GTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
GT LL+ V+ R GI T ++E + A++ +TK+I+ ETP NP + V+D+EA ++
Sbjct: 113 GTLALLQTVLPRYGIEVTLVTGDSMESYQEAVKPSTKVIYGETPCNPTMAVLDLEAFAQL 172
>UniRef50_Q5UZ20 Cluster: O-acetylhomoserine (Thiol)-lyase; n=10;
cellular organisms|Rep: O-acetylhomoserine (Thiol)-lyase
- Haloarcula marismortui (Halobacterium marismortui)
Length = 432
Score = 80.6 bits (190), Expect = 3e-14
Identities = 56/172 (32%), Positives = 77/172 (44%), Gaps = 9/172 (5%)
Frame = +2
Query: 128 QKPGFATIAIHAGQEPEKWNSAAVVTPI--VTSTTFKQPAPA------EHTGFEYGRSGN 283
Q GF T A+H GQE + + P+ TS F+ A E G Y R N
Sbjct: 5 QDHGFETDALHVGQEEPDAEARSRAPPLYQTTSYVFEDAEDAAKQFALEKPGHIYSRLMN 64
Query: 284 PTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGGTNRLLRQV 460
PT L+E LAAL+GG + AS + GD++V++ +YGGT
Sbjct: 65 PTVGMLQERLAALEGGVGAVATASGMASLNLATFLLADVGDNVVTASSLYGGTYTYYTHT 124
Query: 461 IARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
R G+ T F D + + A+ ENT + ET NP L D E + +IA
Sbjct: 125 APRNGVETRFVDTLDYDAYAEAIDENTAYVHCETIGNPSLVTPDFERLAEIA 176
>UniRef50_Q0B7N7 Cluster: Cystathionine gamma-synthase; n=4;
Betaproteobacteria|Rep: Cystathionine gamma-synthase -
Burkholderia cepacia (strain ATCC 53795 / AMMD)
Length = 389
Score = 80.2 bits (189), Expect = 4e-14
Identities = 41/119 (34%), Positives = 62/119 (52%), Gaps = 1/119 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTN 442
Y R GNP ++ +A L+G + L AS GDH+V Y T
Sbjct: 53 YTRYGNPVHERVKAIMAELEGTETALVTASGMGAIATAILSVVKAGDHVVGQTRHYMSTT 112
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
++L ++ R G+ TF D T++ A++ NT++I +E+P NPLL V DI A+ +IAR
Sbjct: 113 KMLDDMLRRFGVEVTFVDQTDVAAFDRAIRPNTRLIVLESPVNPLLLVTDIGAVTEIAR 171
>UniRef50_Q5LWC9 Cluster: Cys/Met metabolism PLP-dependent enzyme
family protein; n=5; cellular organisms|Rep: Cys/Met
metabolism PLP-dependent enzyme family protein -
Silicibacter pomeroyi
Length = 403
Score = 79.8 bits (188), Expect = 5e-14
Identities = 54/170 (31%), Positives = 81/170 (47%), Gaps = 9/170 (5%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNSAAVVTPIVTSTT--------FKQPAPAEHTGFEYGRSGNPTR 292
G T AIHAG+ P+ A+ PI S+T F + + Y R NPT
Sbjct: 9 GPMTTAIHAGEAPDPATLASA-PPIHMSSTYVSEDVLGFSAHDLTPQSPYAYSRWANPTV 67
Query: 293 NTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIAR 469
LE +AA+ G + L AS + GDH++ SD Y G L R + R
Sbjct: 68 AMLEAKIAAMQGTEACLCTASGMAAAAAIFFTFLSAGDHVIVSDVSYAGVAELARDTLPR 127
Query: 470 LGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+GI + D +++ V A++ T++I ETP NP+ ++ D+ AI +AR
Sbjct: 128 MGIAVSTVDMSDLAAVAAAIRPETRLIHTETPVNPIGRLTDLAAISALAR 177
>UniRef50_A6LZ85 Cluster: O-acetylhomoserine
aminocarboxypropyltransferase; n=2; Clostridium|Rep:
O-acetylhomoserine aminocarboxypropyltransferase -
Clostridium beijerinckii NCIMB 8052
Length = 434
Score = 79.8 bits (188), Expect = 5e-14
Identities = 56/182 (30%), Positives = 83/182 (45%), Gaps = 11/182 (6%)
Frame = +2
Query: 104 MADHGFLKQKPGFATIAIHAGQEP-EKWNSAAVVTPIVTSTTFK--------QPAPAEHT 256
M+ + + GF T +HAG P E + S AV PI + F+ +
Sbjct: 1 MSYEAYKNNQLGFTTRQLHAGYNPAEHYRSKAV--PIYQTAAFELGDVERCIRLFDYSEE 58
Query: 257 GFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYG 433
G Y R NPT LE LA+L+GG + S GD IV+ + +YG
Sbjct: 59 GHSYVRFSNPTNTVLERRLASLEGGIEAIALGSGMAAISNTFLNIAKSGDEIVAVNTLYG 118
Query: 434 GTNRLLRQVIARLGINTTFTDFTN-IEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVK 610
G+ LL ++ GI F + N IE + + E TK I+ E+ NP + ++DIEA+
Sbjct: 119 GSTTLLNSILPDYGIVGRFVEDENDIESYRKVITEKTKAIYSESLGNPGMNIIDIEAVAN 178
Query: 611 IA 616
+A
Sbjct: 179 LA 180
>UniRef50_A1ZIW0 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=1; Microscilla
marina ATCC 23134|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Microscilla
marina ATCC 23134
Length = 391
Score = 79.8 bits (188), Expect = 5e-14
Identities = 39/119 (32%), Positives = 65/119 (54%), Gaps = 1/119 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTN 442
Y R NPT + LE+ +AAL+ + L FAS N GDH+V Y TN
Sbjct: 52 YTRGHNPTTHILEQKMAALENAEDALVFASGSAAVAAAVIANVNQGDHVVCVQKPYSWTN 111
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+LL + R G+ T D T+ + ++A+Q NT+++++E+P + + D+ A+ +IA+
Sbjct: 112 KLLNSFLNRFGVTNTMVDGTDPQNFESAIQPNTRVLFLESPNSWTFEQQDLAAVAQIAK 170
>UniRef50_Q399B4 Cluster: Cystathionine beta-lyase; n=15;
Proteobacteria|Rep: Cystathionine beta-lyase -
Burkholderia sp. (strain 383) (Burkholderia cepacia
(strain ATCC 17760/ NCIB 9086 / R18194))
Length = 393
Score = 79.4 bits (187), Expect = 6e-14
Identities = 43/122 (35%), Positives = 64/122 (52%), Gaps = 1/122 (0%)
Frame = +2
Query: 254 TGFEYGRSGNPTRNTLEECLAALDGGKYGL-TFASXXXXXXXXXXXXNHGDHIVSSDDVY 430
T YGR G+PT LE+ LA L+G L T + N GDH++ +D VY
Sbjct: 49 TPLAYGRHGSPTTRALEKALARLEGAHAALLTPSGLSAITTALLAVLNPGDHLLMADSVY 108
Query: 431 GGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVK 610
T + +ARLGI TT+ D T + + M+ NT+ ++ E+P + +V DI AI +
Sbjct: 109 DPTRSFCDETLARLGIETTYFDPTIGADIASLMRPNTRAVFAESPGSLTFEVQDIPAISR 168
Query: 611 IA 616
+A
Sbjct: 169 VA 170
>UniRef50_Q338K0 Cluster: Cys/Met metabolism PLP-dependent enzyme
family protein; n=7; Oryza sativa|Rep: Cys/Met
metabolism PLP-dependent enzyme family protein - Oryza
sativa subsp. japonica (Rice)
Length = 433
Score = 79.4 bits (187), Expect = 6e-14
Identities = 53/171 (30%), Positives = 86/171 (50%), Gaps = 15/171 (8%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAA----VVTPIVTSTT--FKQPAP------AEHTGFEYGRSGNPT 289
T+A+HAG++ +AA + TPIV TT F+ A FEYGR GNPT
Sbjct: 83 TLAVHAGEKLGSGAAAAETDSIATPIVGGTTHWFRDSADLIAFREGRRRSFEYGRYGNPT 142
Query: 290 RNTLEECLAALDGGKYGL-TFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIA 466
LEE ++AL+ + L T + G H+V++ D Y +R ++
Sbjct: 143 VKVLEEKISALERAEATLVTSSGMNAIVATLLALVPPGGHVVATADCYSEARAFIRDKLS 202
Query: 467 RLGINTTFTDF-TNIEKVKNAMQE-NTKMIWIETPTNPLLKVVDIEAIVKI 613
+GI +TF D ++E +++ + E M + ++ TNP LKVVD+ + ++
Sbjct: 203 NMGITSTFVDLDDDMEALESVLDEGEVTMFYADSMTNPHLKVVDVTRVAEL 253
>UniRef50_A7TA32 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 175
Score = 79.4 bits (187), Expect = 6e-14
Identities = 57/176 (32%), Positives = 87/176 (49%), Gaps = 24/176 (13%)
Frame = +2
Query: 125 KQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE--------HTGFEYGRSG 280
+QK GF TI IH G + E N+ A +TPI S+T+ + + G+ YGR G
Sbjct: 4 QQKKGFETICIHGGHQQE--NNRAHLTPIYASSTYTFDSAEQAVNIFQGKEEGYVYGRFG 61
Query: 281 NPTRNTLEECLAALDGGKYGLTFA------------SXXXXXXXXXXXXN--HGDHIVSS 418
NPT EE +A ++ YGL + S N G+ I++
Sbjct: 62 NPTIREAEEKIALMEA--YGLQDSNGDNLELKAILHSSGMAAITTMLLSNLKAGEKIITH 119
Query: 419 DDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENT--KMIWIETPTNPLL 580
+YGGT L+ +V+ +GI DF N++KV+ A+Q ++ +++IETP NP L
Sbjct: 120 YSLYGGTQELIDKVLPDMGIEVIIADFNNLDKVEAAIQADSAINLMYIETPANPTL 175
>UniRef50_Q89VE2 Cluster: O-succinylhomoserine sulfhydrylase; n=72;
cellular organisms|Rep: O-succinylhomoserine
sulfhydrylase - Bradyrhizobium japonicum
Length = 417
Score = 78.6 bits (185), Expect = 1e-13
Identities = 40/124 (32%), Positives = 67/124 (54%), Gaps = 1/124 (0%)
Frame = +2
Query: 248 EHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDD 424
E GF Y R NPT + E + L+G + + A+ GDH+V+S
Sbjct: 74 EDPGFIYSRYSNPTISMFERRMIELEGAEAARSAATGMAAVTTAILAPLKTGDHVVASRA 133
Query: 425 VYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAI 604
++G +++ ++ R GI TT D ++++ + A++ NTK ++E+PTNP L V+DI I
Sbjct: 134 LFGSCLYVIQDLLPRYGIETTLVDGLDLDQWQRALRPNTKTFFLESPTNPTLDVLDIPGI 193
Query: 605 VKIA 616
+IA
Sbjct: 194 AEIA 197
>UniRef50_Q895W3 Cluster: O-acetylhomoserine sulfhydrylase; n=40;
Bacteria|Rep: O-acetylhomoserine sulfhydrylase -
Clostridium tetani
Length = 462
Score = 78.6 bits (185), Expect = 1e-13
Identities = 55/177 (31%), Positives = 78/177 (44%), Gaps = 10/177 (5%)
Frame = +2
Query: 119 FLKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE--------HTGFEYGR 274
F+ G TI I G P+ V PI STT+K P G Y R
Sbjct: 37 FMNNSWGKGTICIQGGYNPKPGEPR--VLPIFQSTTYKYEDPDHVAKLFDLTEEGHIYSR 94
Query: 275 SGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLL 451
NPT + EE + L+GG L +S GDHI+S+ +YGGT LL
Sbjct: 95 ISNPTVSAYEEKVNCLEGGAGALAVSSGQSATTLALLNICKSGDHIISASTIYGGTFTLL 154
Query: 452 RQVIARLGINTTFTD-FTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ + GI +F + ++ E + + NTK I+ ET NP L ++D + IA+
Sbjct: 155 SSTLKKFGIEVSFINPDSSKEDILKEFKSNTKAIFAETIGNPGLNILDFDKFSDIAQ 211
>UniRef50_Q6W1U5 Cluster: Cystathionine gamma-synthase; n=2;
Proteobacteria|Rep: Cystathionine gamma-synthase -
Rhizobium sp. (strain NGR234)
Length = 425
Score = 78.6 bits (185), Expect = 1e-13
Identities = 39/120 (32%), Positives = 63/120 (52%), Gaps = 1/120 (0%)
Frame = +2
Query: 260 FEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGG 436
F Y R NPT LE +AAL+G L A+ GDH++ SD Y G
Sbjct: 82 FLYARWTNPTVRQLELRMAALEGADDALATATGVAAIAATFLTCLKRGDHLIISDVCYAG 141
Query: 437 TNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
N L R+++ GI T + + +++V A + NT+++ E+P NP+L++ D+ A+ +A
Sbjct: 142 ANELARRMLPDYGIEVTAVNMSRLDEVAAAFRPNTRLVHCESPCNPILRLTDLSAVAALA 201
>UniRef50_Q46V95 Cluster: Cystathionine beta-lyase, bacterial; n=1;
Ralstonia eutropha JMP134|Rep: Cystathionine beta-lyase,
bacterial - Ralstonia eutropha (strain JMP134)
(Alcaligenes eutrophus)
Length = 418
Score = 78.2 bits (184), Expect = 1e-13
Identities = 51/170 (30%), Positives = 79/170 (46%), Gaps = 13/170 (7%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTF-----------KQPAPAEHTGFE-YGRSGNPT 289
T + AG+ PE++ V TPI ++T K+ AE G YGR G PT
Sbjct: 15 THLVCAGRHPERFGGV-VNTPIFRASTILAGSMAEWEEMKRARAAEEPGATTYGRYGTPT 73
Query: 290 RNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIA 466
LEE +A L+GG L F S + GDH++ +D Y T L +V+A
Sbjct: 74 TQALEEAVAGLEGGYRSLVFPSGLAAVSTALTALLSAGDHVLVTDSAYSPTRAFLERVLA 133
Query: 467 RLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
R G+ D ++ ++ NT+++++E+P + + DI AI A
Sbjct: 134 RFGVEVETYDPVGGTPIEALLRANTRVVYVESPGSETFDIQDIPAIAAAA 183
>UniRef50_A2Z703 Cluster: Putative uncharacterized protein; n=3;
Oryza sativa|Rep: Putative uncharacterized protein -
Oryza sativa subsp. indica (Rice)
Length = 451
Score = 78.2 bits (184), Expect = 1e-13
Identities = 53/169 (31%), Positives = 89/169 (52%), Gaps = 13/169 (7%)
Frame = +2
Query: 146 TIAIHAGQEPEKW--NSAAVVTPIVTSTT--FKQPAP--AEHTG----FEYGRSGNPTRN 295
T+A+HAG++ + ++ TPIV+STT F+ A A G FEYGR GNPT
Sbjct: 84 TLAVHAGEKLGSGAAETDSIATPIVSSTTHWFRDSADLIAFREGWRRSFEYGRYGNPTVK 143
Query: 296 TLEECLAALDGGKYGL-TFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARL 472
LEE ++AL+ + L T + G H+V + D Y + ++++
Sbjct: 144 VLEEKISALERAEATLVTSSGMNAIVATLLALVPPGGHVVVTADCYSEARAFIHDKLSKM 203
Query: 473 GINTTFTDF-TNIEKVKNAMQEN-TKMIWIETPTNPLLKVVDIEAIVKI 613
GI +TF D ++E +++ + E+ M + ++ TNP LKVVD+ + ++
Sbjct: 204 GITSTFVDLDDDMEALESVLDEDEVTMFYADSMTNPHLKVVDVARVAEL 252
>UniRef50_Q97MT9 Cluster: O-acetylhomoserine sulfhydrylase; n=4;
Clostridiales|Rep: O-acetylhomoserine sulfhydrylase -
Clostridium acetobutylicum
Length = 409
Score = 77.8 bits (183), Expect = 2e-13
Identities = 49/169 (28%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE--------HTGFEYGRSGNPTRN 295
F+T IH E N+ A PI S + +P E G+ Y R NPT
Sbjct: 3 FSTKLIHGNYNLE--NTGATNVPIYMSNAYAHSSPQELENVFKGKFPGYVYSRFSNPTVL 60
Query: 296 TLEECLAALDGGKYGLTFASXXXXXXXXXXXXNH-GDHIVSSDDVYGGTNRLLRQVIARL 472
E +A+++GG + AS H GD I++S +YGGT L+ + +
Sbjct: 61 EFERRMASIEGGLTATSAASGMSAIYMAITNIVHPGDEIIASTGLYGGTYTLISN-LQNI 119
Query: 473 GINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
G+ F + + + + N + ENTK+++ ET NP L ++DIE++ ++ +
Sbjct: 120 GVKVIFLEDISKKTLLNNINENTKLVYTETIGNPKLDILDIESVGRVCK 168
>UniRef50_Q2S2T9 Cluster: Cystathionine beta-lyase MetC; n=1;
Salinibacter ruber DSM 13855|Rep: Cystathionine
beta-lyase MetC - Salinibacter ruber (strain DSM 13855)
Length = 382
Score = 77.4 bits (182), Expect = 3e-13
Identities = 54/159 (33%), Positives = 74/159 (46%), Gaps = 2/159 (1%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGN-PTRNTLEECLAAL 322
T +IHAG EPE AV P+ + T+ P Y R N P L E LAAL
Sbjct: 6 TQSIHAG-EPEPRIEGAVSMPVFQTATYTHDDPGASP--RYVRYNNSPNHQALHEKLAAL 62
Query: 323 DGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDF 499
+ L AS GDH+V+ +YGGT LL ++ R GI T
Sbjct: 63 TETERALVTASGMAAISSALLGVLEAGDHLVAPHSLYGGTLALLNDLLPRFGITHTLVPE 122
Query: 500 TNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
E A+Q NTK+++ E TNP L+V+++ +V +A
Sbjct: 123 DTPEAWTAALQPNTKVLYAEAITNPRLEVLNLTGMVDLA 161
>UniRef50_A0L907 Cluster: Cystathionine gamma-synthase; n=1;
Magnetococcus sp. MC-1|Rep: Cystathionine gamma-synthase
- Magnetococcus sp. (strain MC-1)
Length = 396
Score = 77.4 bits (182), Expect = 3e-13
Identities = 47/172 (27%), Positives = 80/172 (46%), Gaps = 7/172 (4%)
Frame = +2
Query: 125 KQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPA------EHTGFEYGRSGNP 286
K + G T A+HAG ++ + +S F A E G Y R NP
Sbjct: 5 KTRYGKNTRALHAGLHASDARENSLAMHVTSSFFFNSAGQAAAVFGDEEEGNIYSRFSNP 64
Query: 287 TRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVI 463
T E+ LA L+ G+ + AS GDH++ S V+G T + + +
Sbjct: 65 TVEAFEQRLAELEEGEACVATASGMAAIFGVFMQLLQQGDHLILSRSVFGSTINVAKNYL 124
Query: 464 ARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ GI F +++ + A++ NTKM ++E+P NP L++ D+ A+ ++A+
Sbjct: 125 TKFGIQIDFVGLADMDGWRRAIRPNTKMFYLESPANPTLEMADLAALGQLAK 176
>UniRef50_Q0SFV6 Cluster: O-acetylhomoserine
aminocarboxypropyltransferase; n=1; Rhodococcus sp.
RHA1|Rep: O-acetylhomoserine
aminocarboxypropyltransferase - Rhodococcus sp. (strain
RHA1)
Length = 432
Score = 77.0 bits (181), Expect = 3e-13
Identities = 53/174 (30%), Positives = 79/174 (45%), Gaps = 9/174 (5%)
Frame = +2
Query: 122 LKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTST-----TFKQPAPA---EHTGFEYGRS 277
+ + GFAT + G +P + A+ PI S +F+Q G Y R+
Sbjct: 1 MPETTGFATRQVRTGYQPGTPQNTAI-PPIYQSVAYDFGSFEQARDIFSLRRKGNLYSRT 59
Query: 278 GNPTRNTLEECLAALDGGKYGL-TFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLR 454
GNPT+ E+ LA LD G L T + G HIV++ +YGGT LL
Sbjct: 60 GNPTQAVFEQRLADLDDGVAALATGSGQSAVAVALLTLAKSGQHIVAARQLYGGTVDLLS 119
Query: 455 QVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
A GI T D +++ + A + T+ + ET NP+ V+D+ A+ IA
Sbjct: 120 DTFADFGIEVTLVDQDDLDAWRAAARPETRAFFAETIGNPVASVLDVRAVADIA 173
>UniRef50_A0V4A3 Cluster: O-acetylhomoserine/O-acetylserine
sulfhydrylase; n=3; Proteobacteria|Rep:
O-acetylhomoserine/O-acetylserine sulfhydrylase -
Delftia acidovorans SPH-1
Length = 475
Score = 77.0 bits (181), Expect = 3e-13
Identities = 50/167 (29%), Positives = 82/167 (49%), Gaps = 10/167 (5%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEH---------TGFEYGRSGNPTRNT 298
T A+HAG + +A V PI ST+F + A+H G Y R+ NPT
Sbjct: 24 TQALHAGYRGREQQRSAAV-PIYQSTSFVFDS-AQHGANLFGLVEEGDVYSRTANPTLAV 81
Query: 299 LEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGGTNRLLRQVIARLG 475
LE+ +AAL+GG L AS + GDH+V + +YGGT+ + V+A G
Sbjct: 82 LEQRIAALEGGVAALALASGMAAIDVALATLASAGDHVVVASQLYGGTHNFIAHVLASRG 141
Query: 476 INTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+ +T + + ++ A+ TK +++E+ NP + D+ + I+
Sbjct: 142 VQSTAVAKDDFQALRRAIGPRTKAVFVESVGNPSGGIADLRQLADIS 188
>UniRef50_Q3JCU1 Cluster: Cystathionine gamma-synthase; n=1;
Nitrosococcus oceani ATCC 19707|Rep: Cystathionine
gamma-synthase - Nitrosococcus oceani (strain ATCC 19707
/ NCIMB 11848)
Length = 398
Score = 76.6 bits (180), Expect = 5e-13
Identities = 52/171 (30%), Positives = 83/171 (48%), Gaps = 12/171 (7%)
Frame = +2
Query: 125 KQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTF-----KQPA---PAEHTGFEYGRSG 280
+Q+ GF T IH E + P+ +T F Q A E G+ Y R G
Sbjct: 4 EQEQGFTTQVIHGHNEKLDPVHGSTTPPLYLNTAFLFENADQGARRFAREEEGYVYARMG 63
Query: 281 NPTRNTLEECLAALDGGKYGLTFAS-XXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQ 457
NP+ LE+ LA L+ G+ FAS GDHI+S ++YGGT
Sbjct: 64 NPSVEMLEKRLALLENGEAAAAFASGMGAISSLLLHLAQPGDHIISVREIYGGTYAFFEG 123
Query: 458 VIARLGINTTFTD--FTNIEKVKNAM-QENTKMIWIETPTNPLLKVVDIEA 601
+ R+G + T+ + ++E +A +++++++ETP+NP L +VD+EA
Sbjct: 124 QLKRMGCSITYFNPAAPDLEAELDAQYTSHSRVLYLETPSNPSLALVDLEA 174
>UniRef50_Q4PK57 Cluster: Predicted cystathionine beta-lyase; n=1;
uncultured bacterium MedeBAC49C08|Rep: Predicted
cystathionine beta-lyase - uncultured bacterium
MedeBAC49C08
Length = 262
Score = 76.6 bits (180), Expect = 5e-13
Identities = 32/75 (42%), Positives = 53/75 (70%), Gaps = 1/75 (1%)
Frame = +2
Query: 398 GDHIVSSDDVYGGTNRLLRQVIA-RLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNP 574
GDHI++ DD+YGGT RL ++ + GI ++ D + + ++ +++ NTKM++ ETPTNP
Sbjct: 20 GDHIIAMDDLYGGTVRLFNEIKSISQGIEISYVDMSKEKNIEASIKPNTKMLFAETPTNP 79
Query: 575 LLKVVDIEAIVKIAR 619
LLK++D+E + AR
Sbjct: 80 LLKIIDLEKLADFAR 94
>UniRef50_UPI0000E47CE2 Cluster: PREDICTED: similar to cystathionine
beta-lyase; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to cystathionine beta-lyase -
Strongylocentrotus purpuratus
Length = 392
Score = 76.2 bits (179), Expect = 6e-13
Identities = 35/122 (28%), Positives = 63/122 (51%), Gaps = 1/122 (0%)
Frame = +2
Query: 257 GFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYG 433
G+ YGR N + + + + ++GG + S GDHI++ D VY
Sbjct: 87 GYVYGRCNNHSCDVVAHAVNKIEGGVGACVYPSGMSAISNNILAVVKTGDHIIAPDPVYS 146
Query: 434 GTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
G L+ VI G+ TF +++ + A++ NTK+ + ETPTNP++ ++D++A +
Sbjct: 147 GVYAFLKHVIGNYGVEVTFVPSGDLDAYRKAIKPNTKVFYGETPTNPVMSLLDLKAFADL 206
Query: 614 AR 619
A+
Sbjct: 207 AK 208
>UniRef50_Q7X137 Cluster: Cystathionine gamma lyase-like protein;
n=1; Pseudomonas fluorescens|Rep: Cystathionine gamma
lyase-like protein - Pseudomonas fluorescens
Length = 381
Score = 76.2 bits (179), Expect = 6e-13
Identities = 43/140 (30%), Positives = 68/140 (48%)
Frame = +2
Query: 200 VTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXX 379
VTPI + F + + F Y R NP LE+ +AAL+G +Y L +++
Sbjct: 21 VTPIYQCSAF-----SADSAFFYSRKANPNVTELEQVVAALEGSEYALAYSTGMSAIYMV 75
Query: 380 XXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIE 559
G +V + +YG + +L ++ AR+G T D T +K + + M+ E
Sbjct: 76 LELLKPGGSLVINKYIYGCSYKLFQRYAARIGAKLTILDLTTESGLKE-LPSDVDMVIFE 134
Query: 560 TPTNPLLKVVDIEAIVKIAR 619
TPTNP LK +DI A+ K +
Sbjct: 135 TPTNPFLKDIDIHAVSKAVK 154
>UniRef50_A4AA77 Cluster: Cystathionine beta-lyase; n=2;
Bacteria|Rep: Cystathionine beta-lyase - Congregibacter
litoralis KT71
Length = 439
Score = 76.2 bits (179), Expect = 6e-13
Identities = 38/131 (29%), Positives = 67/131 (51%), Gaps = 1/131 (0%)
Frame = +2
Query: 230 KQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXX-XXNHGDH 406
++ AP + YGR G PT LE+ + LD + S + GDH
Sbjct: 87 REAAPLDREHMYYGRMGTPTTRALEDAICELDNSVGAVLATSGTASIASILNCYLSPGDH 146
Query: 407 IVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKV 586
++ D VYG T + +AR G+ T+F D E +++ + ++T+MI++E+P + ++
Sbjct: 147 LLMVDSVYGPTRKFCVGSLARRGVRTSFYDPLKHESLESLIDDSTRMIFMESPGSATFEI 206
Query: 587 VDIEAIVKIAR 619
D+ AIV +A+
Sbjct: 207 QDVPAIVAVAK 217
>UniRef50_A1SMU4 Cluster: O-acetylhomoserine/O-acetylserine
sulfhydrylase; n=6; Bacteria|Rep:
O-acetylhomoserine/O-acetylserine sulfhydrylase -
Nocardioides sp. (strain BAA-499 / JS614)
Length = 428
Score = 76.2 bits (179), Expect = 6e-13
Identities = 53/166 (31%), Positives = 76/166 (45%), Gaps = 9/166 (5%)
Frame = +2
Query: 146 TIAIHAGQEPEK--WNSAAVVTPIVTSTTFKQPAPAEHT------GFEYGRSGNPTRNTL 301
T+A+HAGQE NS AV TS F A + G Y R NPT++
Sbjct: 7 TLAVHAGQEEHDPATNSRAVPIYQTTSYVFNDTEHAANLFSLAEPGNIYTRIMNPTQDVF 66
Query: 302 EECLAALDGGKYGLTFASXXXXXXXXXXXXNH-GDHIVSSDDVYGGTNRLLRQVIARLGI 478
E+ + L+GG L AS + GD+IV+ +YGGT L + + GI
Sbjct: 67 EQRMTQLEGGVGALAVASGSTATTYAVLNLTYAGDNIVALSTLYGGTYALFAHTLPQFGI 126
Query: 479 NTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
F D E + + + T++++ ET NP + VVDI A + A
Sbjct: 127 EVRFVDPDRPEDLAKVVDDKTRLVFGETVGNPRINVVDIPAWAEAA 172
>UniRef50_A1A0Q5 Cluster: Cystathionine beta-lyase; n=2;
Bifidobacterium adolescentis|Rep: Cystathionine
beta-lyase - Bifidobacterium adolescentis (strain ATCC
15703 / DSM 20083)
Length = 411
Score = 76.2 bits (179), Expect = 6e-13
Identities = 55/169 (32%), Positives = 77/169 (45%), Gaps = 10/169 (5%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAA 319
F T +H G N+ AV PI S+T+ + ++Y RSGNPTR LE+ +A
Sbjct: 4 FNTQLVH-GLPVNDNNTGAVNPPIYNSSTYAFESVGTMPRWDYARSGNPTREFLEKQIAQ 62
Query: 320 LDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGI---NTTF 490
L+ G G F S GD I+ ++YGGT L + R G+
Sbjct: 63 LEHGTRGFAFGSGLAAIHAVLSIFQPGDRIIVGKNIYGGTYSLFHEYFERWGVIVEEVGT 122
Query: 491 TDFTNI------EKVK-NAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
TD+ + E K NA K ++ E TNPLL+V ++ AI IA
Sbjct: 123 TDYKALDAAVSGESAKGNAHGCPAKAVYFEVLTNPLLQVNNVTAIAGIA 171
>UniRef50_P53101 Cluster: Cystathionine beta-lyase; n=5;
Saccharomycetales|Rep: Cystathionine beta-lyase -
Saccharomyces cerevisiae (Baker's yeast)
Length = 465
Score = 75.8 bits (178), Expect = 8e-13
Identities = 53/170 (31%), Positives = 81/170 (47%), Gaps = 12/170 (7%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHT-GFEYGRSGNPTRNTLEECLAAL 322
T+ ++ G + ++ +A V P+ STTFK E ++Y RSGNPTR+ L+ + L
Sbjct: 8 TVVVNTGSQNDQ--HSASVPPVYLSTTFKVDLNNEDAQNYDYSRSGNPTRSVLQHQIGKL 65
Query: 323 D--------GGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLG 475
G+T NH I++ DD+YGGT RLL +
Sbjct: 66 YRVPQENVLAVSSGMTALDVILRGLVLLNGTDNHTPTIIAGDDLYGGTQRLLNFFKQQSH 125
Query: 476 INTTFTDFTNIEKVKNAMQENTKM--IWIETPTNPLLKVVDIEAIVKIAR 619
+ D ++ EK K Q K+ + +E+PTNPL KVVDI I++ +
Sbjct: 126 AVSVHVDTSDFEKFKTVFQSLDKVDCVLLESPTNPLCKVVDIPRILRFVK 175
>UniRef50_Q8FRS9 Cluster: O-acetylhomoserine sulfhydrylase; n=8;
Bacteria|Rep: O-acetylhomoserine sulfhydrylase -
Corynebacterium efficiens
Length = 438
Score = 75.4 bits (177), Expect = 1e-12
Identities = 57/170 (33%), Positives = 82/170 (48%), Gaps = 10/170 (5%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNSAAVVTPIVTSTTF--------KQPAPAEHTGFEYGRSGNPTR 292
GF T +IHAGQ P ++ + PI +T F KQ E G Y R NPT
Sbjct: 14 GFETRSIHAGQ-PVDSDTGSRNLPIHLTTAFVFDSAEHAKQRFALEDLGPVYTRLTNPTV 72
Query: 293 NTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNH-GDHIVSSDDVYGGTNRLLRQVIAR 469
+E + L+GG + + FAS G H+V+S +YGGT L + R
Sbjct: 73 EAVENRINNLEGGAHTVFFASGQAATTAAILNLGGAGSHVVTSPRLYGGTETLFLVTLKR 132
Query: 470 LGINTTFTDF-TNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
LGI TF + + E + A+++NT + ET NP V+DI A+ ++A
Sbjct: 133 LGIEFTFVENPDDPESWQAAVRDNTIAFFGETFANPQADVLDIPAVSEVA 182
>UniRef50_Q7M9C8 Cluster: O-ACETYLHOMOSERINE SULFHYDRYLASE; n=1;
Wolinella succinogenes|Rep: O-ACETYLHOMOSERINE
SULFHYDRYLASE - Wolinella succinogenes
Length = 407
Score = 75.4 bits (177), Expect = 1e-12
Identities = 50/168 (29%), Positives = 79/168 (47%), Gaps = 9/168 (5%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNSAAVVTPIVTSTTFK--------QPAPAEHTGFEYGRSGNPTR 292
GF T A+H + + A + TP+ + F+ Q + G Y RS NPT
Sbjct: 3 GFTTRALHVPKAKRDVHGA-LRTPVYDNAAFEFENSDEIAQVSLGRALGHVYSRSSNPTV 61
Query: 293 NTLEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGGTNRLLRQVIAR 469
LE+ L L G L S GD +V++D ++G T L ++ +
Sbjct: 62 EDLEQRLKNLTGALGVLALGSGMAAISTAILTLARAGDSVVTTDRLFGHTLSLFQKTLPS 121
Query: 470 LGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
GI F D + V++A E TK++++ET +NP L+V D+EA+ K+
Sbjct: 122 FGIEVRFVDVMDSLAVEHACDETTKLLFLETISNPQLQVADLEALSKV 169
>UniRef50_Q1AT24 Cluster: Cystathionine gamma-synthase; n=2;
Bacteria|Rep: Cystathionine gamma-synthase - Rubrobacter
xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 410
Score = 74.9 bits (176), Expect = 1e-12
Identities = 57/181 (31%), Positives = 80/181 (44%), Gaps = 21/181 (11%)
Frame = +2
Query: 140 FATIAIHAGQE-PEKWNSAA------VVTPIVTSTTFKQPAP--------AEHTGFEYGR 274
F T A+HAG+ P + TPI STTF E G+ Y R
Sbjct: 11 FETRAVHAGESRPGAGGDRGGDGFYPISTPIYASTTFSHADAQTTDRVLGGEEPGYSYAR 70
Query: 275 SGNPTRNTLEECLAALD---GGKYGLTFASXXXXXXXXXXXXNHGD--HIVSSDDVYGGT 439
GNP+ LEE L AL+ GG L FAS G+ ++++D +YG T
Sbjct: 71 WGNPSVAALEEALTALEAPQGGARALAFASGMAAMHAALTAAELGEGARVLAADQLYGST 130
Query: 440 NRLLRQVIARLGINTTFTD-FTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
LL Q+ G +F D + E K + + +ET +NPLL+V DI + +I+
Sbjct: 131 ATLLLQIFGPAGTEASFFDAYDPGEAEKKVSSLRPRAVVVETISNPLLRVADIPRLAEIS 190
Query: 617 R 619
R
Sbjct: 191 R 191
>UniRef50_A6GHC8 Cluster: Cystathionine gamma-synthase; n=1;
Plesiocystis pacifica SIR-1|Rep: Cystathionine
gamma-synthase - Plesiocystis pacifica SIR-1
Length = 369
Score = 74.9 bits (176), Expect = 1e-12
Identities = 44/126 (34%), Positives = 65/126 (51%), Gaps = 7/126 (5%)
Frame = +2
Query: 263 EYGRSGNPTRNTLEECLAAL-----DGGKYG--LTFASXXXXXXXXXXXXNHGDHIVSSD 421
EYGR GNPT E LAAL DGG G L + G H++ +
Sbjct: 28 EYGRYGNPTVAATEAKLAALEAGEADGGGCGAVLMASGMAAITTTLLAMLRAGQHVIFTA 87
Query: 422 DVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEA 601
DVY T R +A+ G+ T +E ++ A+++ T++I+ E PTNP L+VVD+E
Sbjct: 88 DVYRKTRLFARSYLAKFGVEFDIVAPT-LEAIEGAVRDTTRIIFTEAPTNPYLRVVDLEG 146
Query: 602 IVKIAR 619
+V +A+
Sbjct: 147 VVALAK 152
>UniRef50_A4AND2 Cluster: Cystathionine gamma-lyase; n=2; cellular
organisms|Rep: Cystathionine gamma-lyase -
Flavobacteriales bacterium HTCC2170
Length = 396
Score = 74.9 bits (176), Expect = 1e-12
Identities = 42/127 (33%), Positives = 69/127 (54%), Gaps = 2/127 (1%)
Frame = +2
Query: 245 AEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXX-XXXXNHGDHIVSSD 421
+EH F Y R NPT +EE +A L G+ F S DH+V+
Sbjct: 51 SEH--FIYSRGKNPTVKLVEEKIALLANGEKAQLFPSGMAAITASCLHFLRPNDHVVAIK 108
Query: 422 DVYGGTNRLLRQVIAR-LGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIE 598
++YG + LL+ +++ + I TTF +IE ++A++ENT +I++E+P+ + + DIE
Sbjct: 109 NLYGPASNLLKSYLSKKMNIETTFVSGEHIEDFEDAIRENTALIYLESPSTAVFSLQDIE 168
Query: 599 AIVKIAR 619
AI +AR
Sbjct: 169 AIANLAR 175
>UniRef50_Q8RI68 Cluster: Cystathionine gamma-synthase; n=1;
Fusobacterium nucleatum subsp. nucleatum|Rep:
Cystathionine gamma-synthase - Fusobacterium nucleatum
subsp. nucleatum
Length = 396
Score = 74.5 bits (175), Expect = 2e-12
Identities = 44/150 (29%), Positives = 73/150 (48%), Gaps = 1/150 (0%)
Frame = +2
Query: 170 EPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTF 349
+PE + + S T + A AE + Y R+ NP R+ L + + L+ G+ L F
Sbjct: 25 KPEAFPLFTTTAFTMNSLTEVKKAYAEK--YTYIRTCNPNRDALADMVTFLEAGEKSLIF 82
Query: 350 ASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNA 526
+S GDH+V + ++YG T + +++ + GI+ DF +IE K A
Sbjct: 83 SSGMGAITTTIMTILKPGDHVVCNRNIYGETFDVFTKLMPKFGISADLVDFDDIENCKKA 142
Query: 527 MQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
++ TK+I+ E NP L + DI + IA
Sbjct: 143 IKAETKLIYSEVFANPTLNIADIPTLADIA 172
>UniRef50_A5CVL3 Cluster: O-succinylhomoserine sulfhydrylase; n=3;
Bacteria|Rep: O-succinylhomoserine sulfhydrylase -
Vesicomyosocius okutanii subsp. Calyptogena okutanii
(strain HA)
Length = 388
Score = 74.5 bits (175), Expect = 2e-12
Identities = 37/119 (31%), Positives = 69/119 (57%), Gaps = 1/119 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGL-TFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTN 442
Y R NPT + E+ LA L+G + + T + GDHIV+S +++G +
Sbjct: 54 YARFTNPTVDAFEKKLAILEGAQACVATSSGMAAIFATIMALFKSGDHIVASRNMFGTSI 113
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+L +I + I+ +F + +++ +N ++ NTK+ +ETP+NPL +VV+I A+ +I++
Sbjct: 114 IMLNTIITKFNIDISFVNLSDLSAWENTLKNNTKLFLLETPSNPLGEVVNINALSRISK 172
>UniRef50_Q1ELY9 Cluster: Cystathionine beta-lyases/cystathionine
gamma-synthases; n=1; uncultured Thermotogales
bacterium|Rep: Cystathionine beta-lyases/cystathionine
gamma-synthases - uncultured Thermotogales bacterium
Length = 380
Score = 74.1 bits (174), Expect = 2e-12
Identities = 50/163 (30%), Positives = 87/163 (53%), Gaps = 4/163 (2%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNSAAVVTPIVTSTTF---KQPAPAEHTGFEYGRSGNPTRNTLEE 307
GF T A+H G+E + ++ AV TPI ++ F + +E++ Y R GNP+ +E
Sbjct: 3 GFNTRAVHIGEERKIFD--AVSTPIFQTSNFVVDDEKYASENSETFYTRVGNPSIGVVER 60
Query: 308 CLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINT 484
L+ L GG G+ F+S G ++V S ++YGGT LL + +G+
Sbjct: 61 KLSDLFGGAGGIFFSSGMGAITTIFLTFLRSGMNLVISRNIYGGTQSLLGD-LPDMGVEI 119
Query: 485 TFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
D + +E +++ + +NT ++++E+ TNP L + DI+ I I
Sbjct: 120 RRFDQSRLEGLESLVDDNTGIVYVESMTNPNLILSDIQRISHI 162
>UniRef50_UPI0000E0F9F5 Cluster: hypothetical protein OM2255_22574;
n=1; alpha proteobacterium HTCC2255|Rep: hypothetical
protein OM2255_22574 - alpha proteobacterium HTCC2255
Length = 411
Score = 73.7 bits (173), Expect = 3e-12
Identities = 37/116 (31%), Positives = 63/116 (54%), Gaps = 1/116 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTN 442
Y RS + T +L+ + L+ G +TFA+ +GDHI+ SD ++G T
Sbjct: 56 YSRSSSSTNTSLQNVMNHLEQGIGAVTFATGMAAISTVMLSLLKYGDHIIVSDFLFGNTR 115
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVK 610
+ + +LGI +F D T+++ V NA Q NT +++ E+ +NP+ + D+ AI K
Sbjct: 116 SFFKH-LQKLGIEVSFVDVTDVQHVVNAKQPNTVLVFCESLSNPMTHIADLSAIGK 170
>UniRef50_Q2JBH0 Cluster: O-succinylhomoserine sulfhydrylase; n=1;
Frankia sp. CcI3|Rep: O-succinylhomoserine sulfhydrylase
- Frankia sp. (strain CcI3)
Length = 409
Score = 73.7 bits (173), Expect = 3e-12
Identities = 52/169 (30%), Positives = 80/169 (47%), Gaps = 9/169 (5%)
Frame = +2
Query: 137 GFATIAIHAG--QEPEKWNSAAVVTPIVTSTTFKQPAPA------EHTGFEYGRSGNPTR 292
G AT A+ AG Q + +S A+V + +S F A G Y R NPT
Sbjct: 16 GLATEAVRAGHRQSVDDQHSEALV--LTSSYLFDDSHDAAEKFAQRRPGNVYVRFTNPTV 73
Query: 293 NTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIAR 469
EE +A L+G + + AS GDH++ ++ V+G T RL + R
Sbjct: 74 RAFEERVARLEGAESAVATASGMAAFLAVSLGLLRGGDHVLLAEGVFGTTTRLYAHYLDR 133
Query: 470 LGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
G+ TT T+ AM+ T+M+ +E+PTNP++ V DI + ++A
Sbjct: 134 FGVMTTVVPVTDPAAWARAMRAQTRMLVVESPTNPVMAVADIRYLAELA 182
>UniRef50_A3UCA9 Cluster: Cystathionine gamma-synthase; n=2;
Hyphomonadaceae|Rep: Cystathionine gamma-synthase -
Oceanicaulis alexandrii HTCC2633
Length = 378
Score = 73.7 bits (173), Expect = 3e-12
Identities = 46/159 (28%), Positives = 78/159 (49%), Gaps = 2/159 (1%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTG-FEYGRSGNPTRNTLEECLAAL 322
T+A A + ++ + AV+ P+ +TTF + G +Y R PT + LAAL
Sbjct: 7 TLAAQALHQTDR-ETGAVIPPVHPATTFMRDQKNALVGEMDYRRPQGPTEVQAAKVLAAL 65
Query: 323 DGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFT 502
+ F+S G H+V+ ++Y G +LL + ++ I+ +F +
Sbjct: 66 ENAADARLFSSGLAAISAVLDTLEVGAHVVAQTEMYYGAKKLLHHLASKGLISLSFFEPH 125
Query: 503 NIEKVKNAMQ-ENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+I +K A+Q T+++WIETP NP +VDI +IA
Sbjct: 126 DINGLKKAVQGGRTELVWIETPANPSWAIVDIARAAEIA 164
>UniRef50_A3K0Q5 Cluster: O-succinylhomoserine sulfhydrylase; n=3;
Rhodobacteraceae|Rep: O-succinylhomoserine sulfhydrylase
- Sagittula stellata E-37
Length = 391
Score = 73.7 bits (173), Expect = 3e-12
Identities = 44/165 (26%), Positives = 78/165 (47%), Gaps = 8/165 (4%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE-------HTGFEYGRSGNPTRNTLE 304
T +H G + +W + + ++ AE F Y R GNPT E
Sbjct: 7 TRLVHGGTKRSQWGEMSEAIFLTQGFVYETAEAAEARFVKAGDDEFIYARYGNPTMRMFE 66
Query: 305 ECLAALDGGKYGLTFASXXXXXXXXXXXXNH-GDHIVSSDDVYGGTNRLLRQVIARLGIN 481
E L+ G + G AS GDH+V+S ++G +L V+AR G+
Sbjct: 67 ERLSGYLGFEDGFACASGMAAVNGALMALTKAGDHVVASRALFGSCLYVLEDVLARFGVE 126
Query: 482 TTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
T D T+ + A++++T+++++E+ +NP L+V+D+ + K+A
Sbjct: 127 VTLIDGTDNAAWEAAVRDDTRLVFLESISNPTLEVIDLAHVCKVA 171
>UniRef50_A6UGP2 Cluster: Cystathionine gamma-synthase; n=1;
Sinorhizobium medicae WSM419|Rep: Cystathionine
gamma-synthase - Sinorhizobium medicae WSM419
Length = 400
Score = 73.3 bits (172), Expect = 4e-12
Identities = 39/118 (33%), Positives = 58/118 (49%), Gaps = 1/118 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTN 442
Y R GNPT EE +A L GG L AS GDHIV+ Y T+
Sbjct: 55 YSRCGNPTEYKFEEHIAKLTGGTACLATASGMAAISHALFGILKAGDHIVADLTTYSSTH 114
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
G+ + D T++ V+NA+ E TK++++E NP +KV ++A+V++A
Sbjct: 115 EFFDHRAQDFGLKVSLVDCTDVRAVENALTEETKVLYVEAIANPTMKVPPLKALVELA 172
>UniRef50_A0JSU6 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=7;
Actinomycetales|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Arthrobacter sp.
(strain FB24)
Length = 394
Score = 73.3 bits (172), Expect = 4e-12
Identities = 49/162 (30%), Positives = 72/162 (44%), Gaps = 5/162 (3%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALD 325
T+ + AG+ P K A V PIV S+T+ P YGR NPT + LEE L L+
Sbjct: 15 TVVVAAGRPPRK-RDAPVNPPIVLSSTYFGTGPLADGDRGYGRYSNPTWDPLEEALGQLE 73
Query: 326 GGKY-GLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFT 502
G GL +AS G +V Y G+ + ++ + D
Sbjct: 74 GASLPGLLYASGLAAVSSALSLIPAGGVLVMPSHSYAGSLVMATELAEKGLFELRTVDIA 133
Query: 503 NIEKVK----NAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+ + VK A + M+W+E+PTNP+L + DI A+ A
Sbjct: 134 DTDAVKALLAPAEGKPASMLWLESPTNPMLGIADIRALTAAA 175
>UniRef50_A7DHV1 Cluster: O-acetylhomoserine
aminocarboxypropyltransferase precursor; n=2;
Methylobacterium extorquens PA1|Rep: O-acetylhomoserine
aminocarboxypropyltransferase precursor -
Methylobacterium extorquens PA1
Length = 448
Score = 72.9 bits (171), Expect = 6e-12
Identities = 55/169 (32%), Positives = 77/169 (45%), Gaps = 9/169 (5%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTF-----KQPAPA---EHTGFEYGRSGNPTRN 295
FAT A+HAG P+ A V PI + F +Q A TGF Y R NPT
Sbjct: 10 FATQAVHAGAAPDPATGARV-QPIYFTNGFVFDSTEQAADIFAMRKTGFSYSRGSNPTVA 68
Query: 296 TLEECLAALDGGKYGLTFASXXXXXXXXXXXXNH-GDHIVSSDDVYGGTNRLLRQVIARL 472
LE +AAL+G K + +S GD V+S ++GG+ L+R++ R
Sbjct: 69 ALERRVAALEGAKAAVAVSSGQSAVLLVMMTLMQTGDAYVASPRLFGGSLGLMRRLEGRY 128
Query: 473 GINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ F E + A+ TK I E+ NP V+DIE I +A+
Sbjct: 129 DLTPQFAADLTPEAFEAAITPQTKAIICESIVNPCATVMDIEGIAAVAK 177
>UniRef50_Q3IV09 Cluster: O-acetylhomoserine sulfhydrylase; n=1;
Rhodobacter sphaeroides 2.4.1|Rep: O-acetylhomoserine
sulfhydrylase - Rhodobacter sphaeroides (strain ATCC
17023 / 2.4.1 / NCIB 8253 / DSM158)
Length = 440
Score = 72.5 bits (170), Expect = 7e-12
Identities = 45/148 (30%), Positives = 71/148 (47%), Gaps = 9/148 (6%)
Frame = +2
Query: 194 AVVTPIVTSTTFKQPAPAEHTGFE--------YGRSGNPTRNTLEECLAALDGGKYGLTF 349
++V PI +T F+ P E Y R+ NPT LEE + A++ G+ + F
Sbjct: 26 SLVAPIYQTTAFELPEADEAAALFALEKLTPIYARTDNPTTRVLEERMRAVEQGEACICF 85
Query: 350 ASXXXXXXXXX-XXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNA 526
A+ GD+IV+S +++ GT + + LGIN FT+ E +
Sbjct: 86 ATGKAAIVAAICAVTGAGDNIVASRNLFSGTMAMFSATLKNLGINVRFTEQDTAEAFEAL 145
Query: 527 MQENTKMIWIETPTNPLLKVVDIEAIVK 610
E TK+ + ET +NPLLKV I ++ +
Sbjct: 146 SDERTKLWYAETLSNPLLKVFPIASVAR 173
>UniRef50_Q76K51 Cluster: O-acetyl-L-homoserine sulfhydrylase; n=4;
Thermus|Rep: O-acetyl-L-homoserine sulfhydrylase -
Thermus thermophilus
Length = 412
Score = 72.5 bits (170), Expect = 7e-12
Identities = 47/165 (28%), Positives = 77/165 (46%), Gaps = 6/165 (3%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFK-----QPAPAEHTGFEYGRSGNPTRNTLE 304
+ T+A+ AG + + + V + FK Q A G+ Y R +PT LE
Sbjct: 3 YTTLAVLAGLPEDPHGAVGLPIYAVAAYGFKTLEEGQERFATGEGYVYARQKDPTAKALE 62
Query: 305 ECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGIN 481
E L AL+G + AS GD +V++ ++G T L QV++ +G+
Sbjct: 63 ERLKALEGALEAVVLASGQAATFAALLALLRPGDEVVAAKGLFGQTIGLFGQVLSLMGVT 122
Query: 482 TTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+ D E V+ A+ T+ +++ET NP L V D+EA+ +A
Sbjct: 123 VRYVD-PEPEAVREALSAKTRAVFVETVANPALLVPDLEALATLA 166
>UniRef50_A0LY60 Cluster: O-succinylhomoserine sulfhydrylase; n=13;
Bacteria|Rep: O-succinylhomoserine sulfhydrylase -
Gramella forsetii (strain KT0803)
Length = 404
Score = 72.1 bits (169), Expect = 1e-11
Identities = 35/119 (29%), Positives = 65/119 (54%), Gaps = 1/119 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTN 442
Y R NP + E +A ++G + G FA+ N GDHIVS+ V+G T+
Sbjct: 70 YSRFTNPNTSEFVEKIARMEGAETGYAFATGMAAVFSTLAALLNSGDHIVSARSVFGSTH 129
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
L + + I+ ++ D E +++ ++ TK+++ E+PTNP + ++D+E + +IA+
Sbjct: 130 GLFTRYFPKWNISHSYFDVNKPETIEDLIKPETKILFAESPTNPGVDILDLEFLGQIAK 188
>UniRef50_A2BL10 Cluster: Methionine gamma-lyase; n=1; Hyperthermus
butylicus DSM 5456|Rep: Methionine gamma-lyase -
Hyperthermus butylicus (strain DSM 5456 / JCM 9403)
Length = 397
Score = 72.1 bits (169), Expect = 1e-11
Identities = 45/148 (30%), Positives = 71/148 (47%), Gaps = 5/148 (3%)
Frame = +2
Query: 191 AAVVTPIVTSTTFKQP---APA-EHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTF-AS 355
A +VTPI + F P +P ++Y R NPT TLE+ + L+ G+ L F
Sbjct: 30 APIVTPIYRTAPFMFPREDSPMIRGRPYKYSREDNPTIVTLEKAITILEEGEDTLVFNTG 89
Query: 356 XXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQE 535
GD +V++ + YG T LL++ + R G+ + + A +
Sbjct: 90 MAAISTLLFALLGPGDRVVATREAYGSTLHLLKE-LERWGVKVVLAGPDSGDIASEASKP 148
Query: 536 NTKMIWIETPTNPLLKVVDIEAIVKIAR 619
TK++++ET TNPLL V D+ + K AR
Sbjct: 149 GTKLVFVETITNPLLHVTDVPEVAKAAR 176
>UniRef50_A5CMC2 Cluster: O-acetylhomoserine (Thiol)-lyase; n=2;
Actinomycetales|Rep: O-acetylhomoserine (Thiol)-lyase -
Clavibacter michiganensis subsp. michiganensis (strain
NCPPB 382)
Length = 453
Score = 71.7 bits (168), Expect = 1e-11
Identities = 51/170 (30%), Positives = 79/170 (46%), Gaps = 10/170 (5%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE--------HTGFEYGRSGNPTR 292
GF T +HAG + + A V+P+ S F + AE G+ Y R+GNPT
Sbjct: 26 GFTTRQVHAGSAIDG-DHGARVSPVHLSAGFVFDSFAEARDRFAGVDEGYLYTRNGNPTT 84
Query: 293 NTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIAR 469
+ +E LA L+GG + AS GD I+SS +Y G L RQ + R
Sbjct: 85 DEVERRLAELEGGTEAILLASGQAATTTALLAILQAGDRILSSSSIYEGNRGLFRQNLGR 144
Query: 470 LGINTTFT-DFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
LGI F D ++++ + T++++ E NP ++D+ I +A
Sbjct: 145 LGIGVDFVDDHRDLDEWARRITPETRVLFGEPIPNPKNDLLDLAGIADVA 194
>UniRef50_Q11C77 Cluster: Cystathionine beta-lyase; n=1;
Mesorhizobium sp. BNC1|Rep: Cystathionine beta-lyase -
Mesorhizobium sp. (strain BNC1)
Length = 388
Score = 71.3 bits (167), Expect = 2e-11
Identities = 45/167 (26%), Positives = 79/167 (47%), Gaps = 9/167 (5%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTF--------KQPAPAEHTGFEYGRSGNPTRNTL 301
T +HAG+ P+ + V P+ ++TF Q + G YGR+G PT
Sbjct: 10 TTLVHAGRGPQ-YRGNTVSPPVHRASTFLFDTLAEMDQASKTPFRGVFYGRNGTPTSVAF 68
Query: 302 EECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGI 478
E+ +A + + AS N GDH++ D VY R ++AR+GI
Sbjct: 69 EDAMAKISNAHGAIATASGVSAIMGVMLGLLNSGDHVLIPDSVYDIVRRSADGMLARMGI 128
Query: 479 NTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ D +++ ++ NT++I++E+P + +V D+ AIV +A+
Sbjct: 129 EYEYYDPVVGAGIESLLRPNTRLIYLESPGSGTFEVQDVPAIVAVAK 175
>UniRef50_A6GRN0 Cluster: Cystathionine beta-lyase; n=1; Limnobacter
sp. MED105|Rep: Cystathionine beta-lyase - Limnobacter
sp. MED105
Length = 402
Score = 71.3 bits (167), Expect = 2e-11
Identities = 38/121 (31%), Positives = 60/121 (49%), Gaps = 1/121 (0%)
Frame = +2
Query: 260 FEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGG 436
+ YG GNPT+ TL + LA ++G + L S GDH + ++VYG
Sbjct: 60 YSYGLHGNPTQYTLAKKLAEIEGATHALVCPSGLTGIALVAQACLKSGDHWLIPENVYGP 119
Query: 437 TNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
L R + A G+ + D N VK ++ NT ++W E P + +V D++AIV +A
Sbjct: 120 VQALARNLYADYGVEFSEYDPCNAASVKAGLRTNTTLVWTEAPGSLTFEVPDLQAIVALA 179
Query: 617 R 619
+
Sbjct: 180 K 180
>UniRef50_Q67VG6 Cluster: Putative O-succinylhomoserine
(Thiol)-lyase; n=4; Oryza sativa|Rep: Putative
O-succinylhomoserine (Thiol)-lyase - Oryza sativa subsp.
japonica (Rice)
Length = 425
Score = 70.9 bits (166), Expect = 2e-11
Identities = 35/120 (29%), Positives = 64/120 (53%), Gaps = 2/120 (1%)
Frame = +2
Query: 260 FEYGRSGNPTRNTLEECLAALDGGKYGL-TFASXXXXXXXXXXXXNHGDHIVSSDDVYGG 436
FEY R GNPT LE+ ++A++ + + T + G H+V++ D Y
Sbjct: 77 FEYARYGNPTVEVLEDKISAMEKAEATIVTSSGMNAIVATLLAVVPPGGHVVATTDCYSE 136
Query: 437 TNRLLRQVIARLGINTTFTDFTNIEKVKNAM-QENTKMIWIETPTNPLLKVVDIEAIVKI 613
+R ++++GI TTF D ++E +++ + Q N M + ++ TNP LK VD+ + ++
Sbjct: 137 ARAFIRDRLSKMGIRTTFVDLDDMEALQSVLDQGNVTMFYADSLTNPHLKCVDVRRVAEL 196
>UniRef50_O02215 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 451
Score = 70.9 bits (166), Expect = 2e-11
Identities = 45/156 (28%), Positives = 75/156 (48%), Gaps = 11/156 (7%)
Frame = +2
Query: 185 NSAAVVTPIVTSTTFK-----QPAPAEH-TGFEYGRSGNPTRNTLEECLAALDGGKYGLT 346
N+ VV PI S+T++ Q H F Y R GNPT +E + ++GG L
Sbjct: 78 NADPVVVPIYHSSTYRFKTVDQFNEDNHGANFVYRRCGNPTTENVEVVINEIEGGAGSLL 137
Query: 347 FASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEK--- 514
+ S + G H++ + +Y GT+ + + +AR G+ T D +
Sbjct: 138 YNSGLAAISAVFLEFLSSGAHMIVMNPIYSGTSSFINETLARFGVEITSVDVEKEKDFAG 197
Query: 515 -VKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
V+ A++ NTKMI+ E+ NP + V DI +++A+
Sbjct: 198 AVEKAIRPNTKMIYFESIANPTMAVPDILGTIEVAK 233
>UniRef50_Q7M844 Cluster: O-ACETYLHOMOSERINE (THIOL)-LYASE; n=1;
Wolinella succinogenes|Rep: O-ACETYLHOMOSERINE
(THIOL)-LYASE - Wolinella succinogenes
Length = 422
Score = 70.5 bits (165), Expect = 3e-11
Identities = 48/167 (28%), Positives = 79/167 (47%), Gaps = 10/167 (5%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEH---------TGFEYGRSGNPTRNT 298
T+AI AG E K ++ PI +T +K EH G Y R NPT +
Sbjct: 5 TLAIQAGYEKGK-GEKSIAVPIYQTTAYKFD-DTEHGANLFDLKELGNIYTRIMNPTTDV 62
Query: 299 LEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGGTNRLLRQVIARLG 475
LE+ +A L+GG L AS G++I+++ +YGGT ++R G
Sbjct: 63 LEKRVALLEGGVAALASASGMASIFYAVANLAQSGENIIATTQLYGGTLNQFTHTLSRFG 122
Query: 476 INTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
I F D + ++ + + ++ ++ E+ TNP + V +I+ + KIA
Sbjct: 123 IEVRFFDGNHPQEARALIDSKSRALFFESLTNPSIDVPEIDTLAKIA 169
>UniRef50_A5MZ94 Cluster: O-acetyl-L-homoserine
sulfhydrylase-related protein; n=4; Bacteria|Rep:
O-acetyl-L-homoserine sulfhydrylase-related protein -
Clostridium kluyveri DSM 555
Length = 442
Score = 70.5 bits (165), Expect = 3e-11
Identities = 52/174 (29%), Positives = 79/174 (45%), Gaps = 10/174 (5%)
Frame = +2
Query: 125 KQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE--------HTGFEYGRSG 280
K+ F TI I G ++ N + V PI + F + GF Y R
Sbjct: 3 KENLRFDTIKIRGGYNSKEHNHSVSV-PIYETAAFDLGSTERAGKLFSFSELGFIYSRLS 61
Query: 281 NPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGGTNRLLRQ 457
NPT LE+ +AALDG + +S G I+++ +YGGT ++
Sbjct: 62 NPTVEVLEKRVAALDGAAGDIALSSGMAAITYTLLNVAEDGGRILTTPYLYGGTLDGFKK 121
Query: 458 VIARLGINTT-FTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+ + GI F DF N E + ++ +TK I++E+ +NP V DIE I K+A
Sbjct: 122 LYPKFGIKIDKFEDFNNPEALAKQIKPDTKAIFVESISNPNAAVADIEKIAKVA 175
>UniRef50_Q6AJ03 Cluster: Probable cystathionine beta-lyase; n=1;
Desulfotalea psychrophila|Rep: Probable cystathionine
beta-lyase - Desulfotalea psychrophila
Length = 386
Score = 69.7 bits (163), Expect = 5e-11
Identities = 36/125 (28%), Positives = 63/125 (50%), Gaps = 1/125 (0%)
Frame = +2
Query: 248 EHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNH-GDHIVSSDD 424
++ G YG P + EE L L+GG+ F S GDHIV D+
Sbjct: 50 KYPGLTYGTDRLPAQRAFEEALCQLEGGEICRAFQSGINAIVHTLQAFTKAGDHIVVCDN 109
Query: 425 VYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAI 604
VY T+ +V+++ G+ ++ + + +++NT +I++E+P + ++ DIEAI
Sbjct: 110 VYWPTSNFCNKVLSKFGVEISYAPSAVGADIADYLRDNTSLIFMESPGSNTFEIQDIEAI 169
Query: 605 VKIAR 619
+IAR
Sbjct: 170 TQIAR 174
>UniRef50_O69592 Cluster: O-succinylhomoserine sulfhydrylase; n=19;
Bacteria|Rep: O-succinylhomoserine sulfhydrylase -
Mycobacterium leprae
Length = 426
Score = 69.7 bits (163), Expect = 5e-11
Identities = 42/165 (25%), Positives = 76/165 (46%), Gaps = 7/165 (4%)
Frame = +2
Query: 143 ATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEH--TG----FEYGRSGNPTRNTLE 304
AT+ + G ++ A + + ++ AE TG F Y R GNPT E
Sbjct: 40 ATVGVRGGLLRSRFEETAETMYLTSGYVYESAVVAEKSFTGELDHFVYSRYGNPTVTMFE 99
Query: 305 ECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGIN 481
E L ++G AS GD +V++ ++G + +++ R G+
Sbjct: 100 ERLRLIEGAPAAFVTASGMAAVFTSLGALLASGDRLVAARSLFGSCFVVCNEILPRWGVE 159
Query: 482 TTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
T F D ++ + + A+ T+ ++ ETP+NP+ +VDI A+ ++A
Sbjct: 160 TVFVDGEDLVQWEQALSVPTQAVFFETPSNPMQSLVDIAAVTELA 204
>UniRef50_A5V1Q1 Cluster: Cystathionine gamma-synthase; n=2;
Roseiflexus|Rep: Cystathionine gamma-synthase -
Roseiflexus sp. RS-1
Length = 409
Score = 69.7 bits (163), Expect = 5e-11
Identities = 51/174 (29%), Positives = 78/174 (44%), Gaps = 16/174 (9%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQP-------APAEHTGFEYGRSGNPTRNTLE 304
T +HAG+ S TPI TS T+ P A +G+ Y R GNPT LE
Sbjct: 12 TRLVHAGERAPAPGSTPTATPIYTSATYLHPDLAALDTALESGSGYVYTRYGNPTVAALE 71
Query: 305 ECLAALDGGKYGLTFASXXXXXXXXXXXXN--HGDH------IVSSDDVYGGTNRLLRQV 460
E + ++ G FAS G I+++ D+YG T LL++
Sbjct: 72 EAMTVVERGAGATAFASGMAALYAALLAAGTPRGATAPAPRAILAARDMYGATTLLLQEF 131
Query: 461 IARLGINTTFTDFTNIEKVKNAMQENTK-MIWIETPTNPLLKVVDIEAIVKIAR 619
A G D ++ V A++ + ++ +E +NPLL+V+DI A+ + AR
Sbjct: 132 FAARGTRIVTCDMCDLNAVDAALEAHRPDVLLVEQLSNPLLRVIDIRALAQRAR 185
>UniRef50_Q97CC7 Cluster: Cystathionine beta lyase /
O-succinylhomoserine lyase; n=5; Thermoplasmatales|Rep:
Cystathionine beta lyase / O-succinylhomoserine lyase -
Thermoplasma volcanium
Length = 394
Score = 69.7 bits (163), Expect = 5e-11
Identities = 60/184 (32%), Positives = 91/184 (49%), Gaps = 13/184 (7%)
Frame = +2
Query: 92 NKIGMADHGFLKQKPGFATIAIHAGQ--EPEKWNSAAVVTPIVTSTTFKQP-----APAE 250
NK+ MA+ GF T A+ +G+ +P N V TPI ++TF P A +
Sbjct: 2 NKVRMAEKRLFN---GFNTRAVQSGELRDPRFGN---VTTPIFETSTFVFPNSEKDAYID 55
Query: 251 HTG---FEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSS 418
+T + Y R GNPT EE A+L+ ++ L+F+S GD I+S
Sbjct: 56 NTRNLPYIYTRWGNPTVQAFEEKYASLEKAEHALSFSSGMGAITSVILALAERGDKILSV 115
Query: 419 DDVYGGTNRLLRQVIARLGINTTF--TDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVD 592
D+YG T L +V+ GI+ + TD N + K + +I++E+ TNP LKV D
Sbjct: 116 SDLYGQTFYFLNKVLPEYGISVEYISTDRLNSGEFK---PSDYDIIYLESITNPTLKVPD 172
Query: 593 IEAI 604
I+A+
Sbjct: 173 IKAV 176
>UniRef50_Q7UQA0 Cluster: Cystathionine gamma-synthase; n=4;
Bacteria|Rep: Cystathionine gamma-synthase -
Rhodopirellula baltica
Length = 434
Score = 69.3 bits (162), Expect = 7e-11
Identities = 50/190 (26%), Positives = 84/190 (44%), Gaps = 16/190 (8%)
Frame = +2
Query: 98 IGMADHGFLKQKP---GFATIAIHAGQEPEKWN----SAAVVTPIVTSTTFKQPAPAEHT 256
+ M DH P G +T +H +P+ + A+ PI +++TF + +
Sbjct: 26 VEMTDHASRAAGPSSTGLSTQCVHGNIDPDSPSRQHAEGAITAPIYSASTFTFESTDKLL 85
Query: 257 GF--------EYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHI 409
F EYGR GNP +E+ LAALD + + ++S + GD I
Sbjct: 86 DFVEGREQREEYGRYGNPNERLVEQKLAALDNAEDAVVYSSGMAAIVGLLMSRLSSGDEI 145
Query: 410 VSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVV 589
+ D Y + + +A+ G+ T + ++ A+ TKM+ E+PTNP L V
Sbjct: 146 IFFDQCYHRSREFCGKHLAKFGVVTRQVPTGDFAAMEAAITPRTKMLVSESPTNPHLTCV 205
Query: 590 DIEAIVKIAR 619
D+E V + +
Sbjct: 206 DLEQFVALGK 215
>UniRef50_Q8J0B2 Cluster: Homocysteine synthase-like protein; n=2;
Neotyphodium uncinatum|Rep: Homocysteine synthase-like
protein - Neotyphodium uncinatum
Length = 473
Score = 68.9 bits (161), Expect = 9e-11
Identities = 49/164 (29%), Positives = 73/164 (44%), Gaps = 9/164 (5%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHT--------GFEYGRSGNPTRN 295
F T +H G+ P+ S AV P+ +S F+ + A G Y R NPT N
Sbjct: 25 FETQLLHVGRFPDILGSCAV--PVYSSAAFEFNSVAHGARLLNLTQFGNIYSRFTNPTVN 82
Query: 296 TLEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGGTNRLLRQVIARL 472
L+ LA L+GG AS GD+ VSS V+ GT + ++
Sbjct: 83 VLQNRLAGLEGGVAACAVASGSAAVVVTVMALAGVGDNFVSSFHVHAGTFHQFESLAKQM 142
Query: 473 GINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAI 604
GI F + A+ + TK +W+ET +NP ++D+EA+
Sbjct: 143 GIECRFVKSRDPADFAAAIDDKTKFVWLETISNPGNVILDLEAV 186
>UniRef50_A0VE37 Cluster: Cystathionine beta-lyase; n=2;
Comamonadaceae|Rep: Cystathionine beta-lyase - Delftia
acidovorans SPH-1
Length = 407
Score = 68.5 bits (160), Expect = 1e-10
Identities = 47/178 (26%), Positives = 85/178 (47%), Gaps = 13/178 (7%)
Frame = +2
Query: 125 KQKP-GFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFE-----------Y 268
K +P G +T +HAG + S V P+V ++T + A + Y
Sbjct: 7 KHRPLGPSTRLLHAGTPQLQGGSGPVNVPVVRTSTVRFADSAAYADLHHRREAGERLASY 66
Query: 269 GRSGNPTRNTLEECLAALDGGKYG-LTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNR 445
GR G T LE+ + AL+GG LT + + GDH + +D VY R
Sbjct: 67 GRHGLDTHRALEDAVVALEGGHRAFLTPSGLSAITLVLIALLSPGDHALVADSVYSPVRR 126
Query: 446 LLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ ++ RLGI + + + + ++ NT+++++E+P++ L +V+D+ A+ +AR
Sbjct: 127 VDATLLQRLGITLEYFSPSR-DDLAGKIRPNTRLVYLESPSSLLYEVLDLPALAAVAR 183
>UniRef50_Q7P3Q8 Cluster: Methionine gamma-lyase; n=1; Fusobacterium
nucleatum subsp. vincentii ATCC 49256|Rep: Methionine
gamma-lyase - Fusobacterium nucleatum subsp. vincentii
ATCC 49256
Length = 79
Score = 68.1 bits (159), Expect = 2e-10
Identities = 25/57 (43%), Positives = 45/57 (78%)
Frame = +2
Query: 446 LLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
++ + +LG+ TF D +N+++VK AM++NT+++++ETP NP LK+VD+EA+ K+A
Sbjct: 1 MMNHGLTKLGVEVTFVDTSNLDEVKKAMKKNTRVVYLETPANPNLKIVDLEALAKLA 57
>UniRef50_A5ZYG7 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus obeum ATCC 29174|Rep: Putative
uncharacterized protein - Ruminococcus obeum ATCC 29174
Length = 417
Score = 68.1 bits (159), Expect = 2e-10
Identities = 49/169 (28%), Positives = 77/169 (45%), Gaps = 9/169 (5%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE--------HTGFEYGRSGNPTR 292
GF T +H G E + A V PI S+ F+ E G+ Y R NPT
Sbjct: 5 GFNTTLLH-GTEGNNPHGATQV-PIYQSSAFRHDTAEELEKIFSNKMAGYSYTRINNPTI 62
Query: 293 NTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIAR 469
+ E+ +A L+GG + +S GDH+V++ +YGGT LL ++
Sbjct: 63 ESFEKRMAKLEGGIGSVACSSGMAALSMALMNVLQRGDHVVAAAGLYGGTVELLDELKV- 121
Query: 470 LGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
G+ TT+ + + + T+ ++ ET NP L V DI+ + +IA
Sbjct: 122 YGVTTTYVKVNTPQAFEAEITPETRAVFAETIGNPKLDVTDIQGVAEIA 170
>UniRef50_P43623 Cluster: Putative cystathionine beta-lyase; n=11;
cellular organisms|Rep: Putative cystathionine
beta-lyase - Saccharomyces cerevisiae (Baker's yeast)
Length = 340
Score = 68.1 bits (159), Expect = 2e-10
Identities = 47/167 (28%), Positives = 81/167 (48%), Gaps = 4/167 (2%)
Frame = +2
Query: 131 KPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTF---KQPAPAEHTGFEYGRSGNPTRNTL 301
K G T G+ P++ S V P+ +T K + G YG +G+PT + L
Sbjct: 9 KFGITTQLSVIGRNPDE-QSGFVNPPLYKGSTIILKKLSDLEQRKGRFYGTAGSPTIDNL 67
Query: 302 EECLAALDGGKYGLTFASXXXXXXXXXXXXNH-GDHIVSSDDVYGGTNRLLRQVIARLGI 478
E L GG + AS + GDHI+ +D VY T L ++A+ G+
Sbjct: 68 ENAWTHLTGGAGTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGV 127
Query: 479 NTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
T + D + + ++ ++ NT +I++E+P + ++V DI A+V +A+
Sbjct: 128 ETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAK 174
>UniRef50_Q82YZ5 Cluster: Cystathionine gamma-synthase, putative;
n=1; Enterococcus faecalis|Rep: Cystathionine
gamma-synthase, putative - Enterococcus faecalis
(Streptococcus faecalis)
Length = 395
Score = 67.7 bits (158), Expect = 2e-10
Identities = 36/125 (28%), Positives = 65/125 (52%), Gaps = 1/125 (0%)
Frame = +2
Query: 248 EHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDD 424
E + Y R NPT LE+ +A L+ G+ FAS GDH++ +
Sbjct: 49 EKNNYVYTRGTNPTTEILEKKIARLERGEKCKVFASGMGAISATLFTLLQQGDHVLMVNT 108
Query: 425 VYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAI 604
+YG + + Q + + G++ T D E++ +QENTK+I+ E+P++ +++D+E I
Sbjct: 109 IYGESVSFV-QYLEKFGVSLTKVDVAETEELFQFVQENTKVIYFESPSSQKFELLDLEKI 167
Query: 605 VKIAR 619
+A+
Sbjct: 168 TALAQ 172
>UniRef50_A3JID5 Cluster: Cystathionine beta-lyase; n=3;
Marinobacter|Rep: Cystathionine beta-lyase -
Marinobacter sp. ELB17
Length = 397
Score = 67.7 bits (158), Expect = 2e-10
Identities = 49/157 (31%), Positives = 73/157 (46%), Gaps = 4/157 (2%)
Frame = +2
Query: 158 HAGQEPEKWNSAAVVTPIVTSTTFKQPA--PAEHTGFEYGRSG-NPTRNTLEECLAALDG 328
H Q+ ++ T TT +Q A EH G Y R G NPT LE+ LA L+
Sbjct: 22 HRDQQGSPYSPVYNTTTYRFDTTAEQLAVVKGEHDGNLYTRWGTNPTIKELEQGLAQLES 81
Query: 329 GKYGLTFASXXXXXXXXXXXXNHGDH-IVSSDDVYGGTNRLLRQVIARLGINTTFTDFTN 505
+ GL FAS HG + IV D+YGGT LL LGI F
Sbjct: 82 AQAGLAFASGMAAISATLFA--HGRNGIVCVGDLYGGTQELLMNHFEPLGIPFIFLLNQQ 139
Query: 506 IEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+++++ + + +++ ETP NP + ++DI + + A
Sbjct: 140 LDELEQHLTKPGMLVYCETPANPTMAILDIADLARRA 176
>UniRef50_Q9V088 Cluster: MetB cystathionine gamma-synthase (EC
4.2.99.9) (CGS) (O- succinylhomoserine (Thiol)-lyase);
n=9; Archaea|Rep: MetB cystathionine gamma-synthase (EC
4.2.99.9) (CGS) (O- succinylhomoserine (Thiol)-lyase) -
Pyrococcus abyssi
Length = 393
Score = 67.3 bits (157), Expect = 3e-10
Identities = 43/143 (30%), Positives = 67/143 (46%), Gaps = 5/143 (3%)
Frame = +2
Query: 206 PIVTSTTFKQPAPA----EHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXX 373
P+ + FKQ A T +Y R NPT LE+ LA L+G L F S
Sbjct: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
Query: 374 XXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMI 550
GD +V S + YG T L + ++ + G++ + + + + + E TK++
Sbjct: 93 TLYFSLLEGGDKVVLSMEGYGTTIELAK-LLRKFGVDVKLA-YPSADSLIETIDEETKLV 150
Query: 551 WIETPTNPLLKVVDIEAIVKIAR 619
+ET TNP LKV+D+ + K R
Sbjct: 151 LVETMTNPTLKVIDVPEVAKRCR 173
>UniRef50_Q1GQF1 Cluster: Cystathionine beta-lyase; n=1;
Sphingopyxis alaskensis|Rep: Cystathionine beta-lyase -
Sphingopyxis alaskensis (Sphingomonas alaskensis)
Length = 415
Score = 66.9 bits (156), Expect = 4e-10
Identities = 52/192 (27%), Positives = 83/192 (43%), Gaps = 10/192 (5%)
Frame = +2
Query: 74 DNKYVENKIGMADHGFLKQKPGFATIAIHAGQEPEKWNSAAVVTPIV--TSTTFKQPAPA 247
D K++E H + Q P T A+H G P + ++ P V ST A
Sbjct: 6 DGKWLEEPASPKGHAW--QDP---TRAVHGGPRPR--DQRGLINPPVDRASTIIYDSVEA 58
Query: 248 ---EHTGFE----YGRSGNPTRNTLEECLAALDGG-KYGLTFASXXXXXXXXXXXXNHGD 403
H G YG G T L E ++ L+GG +T + GD
Sbjct: 59 YMDRHQGLYDEVIYGLYGTRTTFALAEAVSELEGGCNTVITSSGTSAIALALTAFVAGGD 118
Query: 404 HIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLK 583
H++ +D VYG T + L V+AR G+ + ++ + NT++I++ETP +
Sbjct: 119 HLLVADCVYGPTRKFLTDVLARFGVEVEYFRPDIGAEIAGLCRSNTRLIYMETPGSQTFD 178
Query: 584 VVDIEAIVKIAR 619
++D+ AI +AR
Sbjct: 179 MIDVPAITAVAR 190
>UniRef50_Q1GNK9 Cluster: Cystathionine beta-lyase; n=4;
Sphingomonadales|Rep: Cystathionine beta-lyase -
Sphingopyxis alaskensis (Sphingomonas alaskensis)
Length = 400
Score = 66.9 bits (156), Expect = 4e-10
Identities = 42/151 (27%), Positives = 69/151 (45%), Gaps = 2/151 (1%)
Frame = +2
Query: 173 PEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYG-LTF 349
P W ++ ++ V K A H YGR G PT L + L A++ G G L +
Sbjct: 36 PPVWRASTILYDTVAD--LKARGHATHDKLYYGRRGTPTVWALADALTAMEPGAAGTLLY 93
Query: 350 ASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNA 526
S + GDH++ D Y T ++ARLG+ TT+ D +
Sbjct: 94 PSGVAANSAGLLALLSPGDHLLMVDSAYEPTRAFCDGMLARLGVTTTYYDPLVGAAIAEL 153
Query: 527 MQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
++ T++I++E+P + +V D+ AI +AR
Sbjct: 154 IRPETRLIFLESPGSLTFEVQDVPAITGVAR 184
>UniRef50_A1SSS1 Cluster: Cystathionine beta-lyase; n=10;
Gammaproteobacteria|Rep: Cystathionine beta-lyase -
Psychromonas ingrahamii (strain 37)
Length = 407
Score = 66.5 bits (155), Expect = 5e-10
Identities = 42/157 (26%), Positives = 70/157 (44%), Gaps = 10/157 (6%)
Frame = +2
Query: 176 EKWNSAAVVTPIVTSTT--FKQPAPAEHTG-------FEYGRSGNPTRNTLEECLAALDG 328
+KW V P+V ++T F G YGR G PT +E +A L+G
Sbjct: 29 KKWTKGVVNPPVVRASTMLFDTMEDMRFAGKNKNNGEMYYGRRGGPTHFAFQEAIAELEG 88
Query: 329 GKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTN 505
G + S GDH++ D+ Y T L ++A GI TT+ D
Sbjct: 89 GAGTALYPSGTAAISSALMSFLKAGDHLLMLDNAYEPTRALCDTLLAGFGIETTYYDPLI 148
Query: 506 IEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+ +Q NTK++++E+P + +++ D+ + +IA
Sbjct: 149 GAGISELIQPNTKVLFLESPGSITMEIQDVPTLSRIA 185
>UniRef50_A1I7W3 Cluster: O-acetylhomoserine
aminocarboxypropyltransferase; n=1; Candidatus
Desulfococcus oleovorans Hxd3|Rep: O-acetylhomoserine
aminocarboxypropyltransferase - Candidatus Desulfococcus
oleovorans Hxd3
Length = 419
Score = 66.5 bits (155), Expect = 5e-10
Identities = 44/168 (26%), Positives = 73/168 (43%), Gaps = 9/168 (5%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE-HTGFE-------YGRSGNPTRN 295
F+T +H + +W A + PI +T F F Y R NPT
Sbjct: 9 FSTRVVHHTRPVAEWQGATL-PPIFQTTAFAHDTAENLSNAFAGKNADPIYSRLTNPTNQ 67
Query: 296 TLEECLAALDGGKYGLTFASXXXXXXXX-XXXXNHGDHIVSSDDVYGGTNRLLRQVIARL 472
LE+ +A L+GG + AS GD V+ ++ T +L + +
Sbjct: 68 ALEKVMAGLEGGAGTIAMASGMAAVANTCMALLRAGDEFVAGTSLFMSTYQLFAGIFKKY 127
Query: 473 GINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
GI + +++ V NA+ + T+ ++IET NP++ V DI A+ +A
Sbjct: 128 GITVRAVNPLDLDAVNNAVTDKTRFVYIETIGNPVMDVPDIRALADLA 175
>UniRef50_Q11FS5 Cluster: Cystathionine beta-lyase; n=5;
Alphaproteobacteria|Rep: Cystathionine beta-lyase -
Mesorhizobium sp. (strain BNC1)
Length = 398
Score = 66.1 bits (154), Expect = 6e-10
Identities = 37/147 (25%), Positives = 67/147 (45%), Gaps = 1/147 (0%)
Frame = +2
Query: 182 WNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGL-TFASX 358
W ++ +V P + + + H + YG G PT TLE +A L+GG + T +
Sbjct: 37 WRASTIVFPDMAAYAARNSKG--HDAYSYGLHGTPTTRTLEAQIARLEGGGRSIVTSSGL 94
Query: 359 XXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQEN 538
+ GD ++ D VY + + R+G++ + D + +
Sbjct: 95 SAITMTLQTMLSPGDTVLLVDTVYPPVREFADRFLRRMGVDIVYYDPAIGAGIAELITAT 154
Query: 539 TKMIWIETPTNPLLKVVDIEAIVKIAR 619
T+++W+E+P + ++V DI AIV AR
Sbjct: 155 TRLVWMESPGSTTMEVQDIPAIVAAAR 181
>UniRef50_Q45278 Cluster: Aminotransferase and dihydrorhizobitoxine
synthase; n=8; Proteobacteria|Rep: Aminotransferase and
dihydrorhizobitoxine synthase - Bradyrhizobium japonicum
Length = 806
Score = 65.3 bits (152), Expect = 1e-09
Identities = 50/170 (29%), Positives = 74/170 (43%), Gaps = 12/170 (7%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHT---------GFEYGRSGNPTRNT 298
T +HAG + A V PI +T ++ H GF Y R NPT
Sbjct: 377 TAVLHAGYRRDPVTKAVAV-PIYQNTAYELDGDLNHIADVYNVKADGFTYTRIINPTTRA 435
Query: 299 LEECLAALDGGKYGLTFASXXXXXXXXXXXXNHG---DHIVSSDDVYGGTNRLLRQVIAR 469
LE+ AA+D G L AS + G D+IV+S +YG T LL + R
Sbjct: 436 LEKRYAAVDMGSDSLAVASGQAATFLAILNLSSGEVGDNIVASPYLYGNTWNLLHNTLKR 495
Query: 470 LGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
LGI+ D E + A+ + T ++ E +NP L + ++ + +I R
Sbjct: 496 LGISVRTADPRRPETFERAIDDRTICLFGEVISNPCLIPLPVKQLAEIGR 545
>UniRef50_A5EU95 Cluster: Cystathionine beta-lyase; n=1;
Bradyrhizobium sp. BTAi1|Rep: Cystathionine beta-lyase -
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Length = 415
Score = 65.3 bits (152), Expect = 1e-09
Identities = 35/132 (26%), Positives = 60/132 (45%), Gaps = 1/132 (0%)
Frame = +2
Query: 227 FKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGD 403
F+ A + GF YG G PT LE+ +A L+G L S GD
Sbjct: 41 FETRAERVYDGFSYGLYGTPTSRLLEDHVAQLEGAARALVVPSGMAAMTLATMAVCRSGD 100
Query: 404 HIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLK 583
++ + +YG ++ + + LGI D + + E T+++W+E+P + +
Sbjct: 101 RVLMPETLYGPARDMILRFLGPLGIAAQTYDPLLDAGIAGLLDERTRLVWVESPGSATFE 160
Query: 584 VVDIEAIVKIAR 619
V D+ AIV +A+
Sbjct: 161 VQDVPAIVAVAK 172
>UniRef50_UPI00015BB00D Cluster: cystathionine gamma-synthase; n=1;
Ignicoccus hospitalis KIN4/I|Rep: cystathionine
gamma-synthase - Ignicoccus hospitalis KIN4/I
Length = 387
Score = 64.9 bits (151), Expect = 1e-09
Identities = 42/157 (26%), Positives = 74/157 (47%), Gaps = 2/157 (1%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALD 325
T +H G+ + + ++VTPI S +K P + G++Y R+ +PT LE AA++
Sbjct: 14 TRLVHGGEYRDS-ETGSIVTPIFVSAIYKYPEGNPY-GYKYARNSSPTIEALERKAAAVE 71
Query: 326 GGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFT 502
+ F+S G +V++ D+YG + + GI D
Sbjct: 72 RAAEAVAFSSGMAAISSAAMALLKPGSKLVTTKDIYGTSYEFFTTFLRSYGIEV---DER 128
Query: 503 NI-EKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVK 610
+ E V + +NT ++++ET +NPLL V ++ I K
Sbjct: 129 GVGEGVLERIDKNTDVVFVETISNPLLIVPPVDEIAK 165
>UniRef50_Q493X0 Cluster: Beta-cystathionase; n=2;
Enterobacteriaceae|Rep: Beta-cystathionase - Blochmannia
pennsylvanicus (strain BPEN)
Length = 395
Score = 64.9 bits (151), Expect = 1e-09
Identities = 47/172 (27%), Positives = 81/172 (47%), Gaps = 12/172 (6%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTF--------KQPAPAEHTGFE---YGRSGNP 286
F T I +G+E +K+ A+ PI+ T+ KQ A H+ + YGR G
Sbjct: 4 FETTLITSGRE-QKYTYGAI-NPIIQRTSSVVFNSIQQKQKAVNNHSTTDKLFYGRYGTI 61
Query: 287 TRNTLEECLAALDGGKYGLTF-ASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVI 463
T +L + + L+ G + + GDHI+ + Y T + R V+
Sbjct: 62 THFSLRQSMTELENGVGCMLYPCGTAAITHTILSFVQPGDHILMTGSAYEPTQKFCRYVL 121
Query: 464 ARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
R+ I+TT+ D + N +Q NT+++ +E+P + ++V D+ +IVK R
Sbjct: 122 KRMNIDTTWFDPLIGNNISNLIQHNTRLVILESPGSITMEVQDVPSIVKTVR 173
>UniRef50_Q47S97 Cluster: Cystathionine gamma-synthase; n=1;
Thermobifida fusca YX|Rep: Cystathionine gamma-synthase
- Thermobifida fusca (strain YX)
Length = 406
Score = 64.9 bits (151), Expect = 1e-09
Identities = 37/125 (29%), Positives = 59/125 (47%), Gaps = 6/125 (4%)
Frame = +2
Query: 260 FEYGRSGNPTRNTLEECLAALDGGK-----YGLTFASXXXXXXXXXXXXNH-GDHIVSSD 421
+ Y R +P + +AAL+G +G FAS H G H+V+S
Sbjct: 53 YAYARIDSPNSDAFAAAVAALEGAHLEGEVHGQGFASGMAAISITLLALTHAGAHVVASR 112
Query: 422 DVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEA 601
+YG T +LL V+ R G+ F D T+ V+ A + T +++ ET NP + V D+
Sbjct: 113 ALYGNTYKLLDVVLRRFGVAVDFVDITDPAAVRAAFRPETVLVYTETLANPTMTVSDLPV 172
Query: 602 IVKIA 616
+ +A
Sbjct: 173 LAALA 177
>UniRef50_A3SR24 Cluster: Cystathionine gamma-synthase; n=3;
Alphaproteobacteria|Rep: Cystathionine gamma-synthase -
Roseovarius nubinhibens ISM
Length = 386
Score = 64.9 bits (151), Expect = 1e-09
Identities = 37/145 (25%), Positives = 70/145 (48%), Gaps = 2/145 (1%)
Frame = +2
Query: 188 SAAVVTPIVTSTTFKQPAP-AEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXX 364
+ A+V PI S T+ + A + Y R GNPT E +A L+G + F+S
Sbjct: 26 TGAIVPPIQPSATYARDEDYAVRRSYMYRRDGNPTTEQAEAIIADLEGAVDCMLFSSGMS 85
Query: 365 XXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQE-NT 541
GDH+V + +Y G + ++ + ++ +++ +++A ++ T
Sbjct: 86 ACMSVIDTLKPGDHVVVPEVMYHGVLQQFQRYAKLHRLEVSYYRPGDLDALRDACRKGKT 145
Query: 542 KMIWIETPTNPLLKVVDIEAIVKIA 616
+++W+E+P NP V DI A ++A
Sbjct: 146 RLVWVESPNNPDWDVTDIAAAAELA 170
>UniRef50_Q5FUW3 Cluster: Cystathionine beta-lyase; n=3;
Acetobacteraceae|Rep: Cystathionine beta-lyase -
Gluconobacter oxydans (Gluconobacter suboxydans)
Length = 405
Score = 64.1 bits (149), Expect = 3e-09
Identities = 36/119 (30%), Positives = 62/119 (52%), Gaps = 2/119 (1%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXX-XXXXXNHGDHIVSSDDVYGGTN 442
YG G+P ++ LEE L+ ++GG + S GDH++ D VYG T
Sbjct: 69 YGAMGSPIQHQLEEMLSRIEGGTHTQVVGSGLAACALPLLAFLGCGDHLLLPDSVYGPTR 128
Query: 443 RLLRQVIARLGINTTFTDFT-NIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
RL ++ R+G+ TT+ T + ++V M+ TK+++ E+P + +V D+ + IA
Sbjct: 129 RLAGTMLQRMGVTTTYYPPTASRDEVLALMRPETKVLFAESPGSHTFEVQDVPMLAGIA 187
>UniRef50_Q1IQ69 Cluster: Cystathionine beta-lyase; n=6;
Bacteria|Rep: Cystathionine beta-lyase - Acidobacteria
bacterium (strain Ellin345)
Length = 407
Score = 63.7 bits (148), Expect = 3e-09
Identities = 46/172 (26%), Positives = 75/172 (43%), Gaps = 10/172 (5%)
Frame = +2
Query: 131 KPGFATIAIHAGQE-PEKWNSAAVVTPIVTSTTFKQPAPAEHT--------GFEYGRSGN 283
K + T IH PE + S +VTP +T P T G+ YG G
Sbjct: 23 KKSWKTKLIHGDSHAPEGFRS--LVTPTYRGSTVLFPDAESVTDQWDQHRVGYTYGLYGT 80
Query: 284 PTRNTLEECLAALDGGKYGL-TFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQV 460
PT L + L+ G++ + T N GDHI+ +++YG +L V
Sbjct: 81 PTTLELAARVCELEDGEHTIITAGGQGAISLIQLSLLNAGDHILIPENIYGPNRKLAYSV 140
Query: 461 IARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+ R G+ T + +++NT+++W E+P + ++V D+ AI K A
Sbjct: 141 LKRFGVEVTVYPPLIGAGIAELIKDNTRLVWCESPGSLTMEVQDVPAIAKAA 192
>UniRef50_Q9SGU9 Cluster: F1N19.23; n=7; Magnoliophyta|Rep: F1N19.23
- Arabidopsis thaliana (Mouse-ear cress)
Length = 441
Score = 63.7 bits (148), Expect = 3e-09
Identities = 42/143 (29%), Positives = 68/143 (47%), Gaps = 3/143 (2%)
Frame = +2
Query: 197 VVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGL-TFASXXXXXX 373
V+ P F ++ + Y R NPT L +AAL+G + T +
Sbjct: 72 VMEPDTMRRMFTGELGPDNDFYVYSRHFNPTVLNLSRQMAALEGTQAAYCTSSGMSAISS 131
Query: 374 XXXXXXNHGDHIVSSDDVYGGTNRLLRQVIAR-LGINTTFTDFTNIEKVKNAMQE-NTKM 547
+ G H+V++ +YGGT+ LL + R I T+F D T+ V NA+ E T++
Sbjct: 132 VMLQLCSSGGHVVAASTLYGGTHALLSHFLPRTCNITTSFVDITDHGAVANAIVEGRTQV 191
Query: 548 IWIETPTNPLLKVVDIEAIVKIA 616
++ E+ NP L V DI + ++A
Sbjct: 192 LYFESVANPTLTVADIPELSRMA 214
>UniRef50_Q6N7A9 Cluster: Putative homocysteine synthase; n=1;
Rhodopseudomonas palustris|Rep: Putative homocysteine
synthase - Rhodopseudomonas palustris
Length = 397
Score = 63.3 bits (147), Expect = 4e-09
Identities = 46/168 (27%), Positives = 76/168 (45%), Gaps = 10/168 (5%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTF--------KQPAPAEHTGFEYGRSGNPTRNTL 301
T+A+H G + AVV PI +T++ ++ E G+ Y R+ NPTR L
Sbjct: 11 TLAVHGGSFRSDPVTGAVVPPIYLTTSYQFQDTEHARRIFALEEIGYTYTRTVNPTREFL 70
Query: 302 EECLAALDGGKYGLTFASXXXXXXXXXXXXNH-GDHIVSSDDVYGGTNRLLRQVIARLGI 478
E ++AL+GG L A+ H GD++V S D+ G N L + + GI
Sbjct: 71 ERRVSALEGGVGALALATGESASLYALLNIAHSGDNVVLSPDIVTGRNAGLVASLRQFGI 130
Query: 479 NTTFTDFT-NIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ F T + E A T+ ++E+ + P L+ + + A+
Sbjct: 131 DVRFAAETGSAESFATATDARTRAYYVESLSVPQLRAFPLAGAAEAAQ 178
>UniRef50_Q97W69 Cluster: O-succinylhomoserine (Thiol)-lyase; n=5;
Archaea|Rep: O-succinylhomoserine (Thiol)-lyase -
Sulfolobus solfataricus
Length = 376
Score = 63.3 bits (147), Expect = 4e-09
Identities = 35/145 (24%), Positives = 68/145 (46%), Gaps = 1/145 (0%)
Frame = +2
Query: 188 SAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXX 367
+ A+ TPI ++ + P E + Y R NPT L + + L+ + G+ F+S
Sbjct: 16 TGAITTPIYQTSAYHYP---EGEKYRYSRESNPTVLELAKKIVELENAEMGIAFSSGMGA 72
Query: 368 XXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTK 544
G+ ++ D++G + R + G+N + N ++ A +
Sbjct: 73 ISTTALALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVEASYPGNNNIIEKAKSKRYD 132
Query: 545 MIWIETPTNPLLKVVDIEAIVKIAR 619
+I++E TNPLL+V+D+ + K+A+
Sbjct: 133 VIFVENITNPLLRVIDVAELSKVAK 157
>UniRef50_Q2K0N3 Cluster: Cystathionine gamma-synthase protein; n=7;
Alphaproteobacteria|Rep: Cystathionine gamma-synthase
protein - Rhizobium etli (strain CFN 42 / ATCC 51251)
Length = 390
Score = 62.9 bits (146), Expect = 6e-09
Identities = 37/119 (31%), Positives = 60/119 (50%), Gaps = 1/119 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFAS-XXXXXXXXXXXXNHGDHIVSSDDVYGGTN 442
Y R NPT E+ LA L+GG+ L FAS GD IV+ VY
Sbjct: 57 YTRGLNPTVRAFEDMLAKLEGGEDALGFASGMAAISSAVLSFVEPGDRIVAVKHVYPDAF 116
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
RL ++ R+ I T+ D + E V A+ K++++E+PT+ +++ D+ A+ +A+
Sbjct: 117 RLFGTILKRMKIEVTYVDGRDEEAVARAL-PGAKLLYLESPTSWVMEAHDVGALAALAK 174
>UniRef50_A5G088 Cluster: Cystathionine gamma-synthase; n=1;
Acidiphilium cryptum JF-5|Rep: Cystathionine
gamma-synthase - Acidiphilium cryptum (strain JF-5)
Length = 416
Score = 62.1 bits (144), Expect = 1e-08
Identities = 53/184 (28%), Positives = 79/184 (42%), Gaps = 26/184 (14%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTF------------------KQPAPAEHTGFEYG 271
TIA+ G +P + N AA P+ S+TF + P + G+ Y
Sbjct: 8 TIAVGHGYDPARHNGAAK-PPVYMSSTFVYRDAAHARSAHEGYAAGRAPDSGDAEGYIYA 66
Query: 272 RSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRL 448
R +P L+ +AALDG + F S GD ++ + +YGGT+ L
Sbjct: 67 RLDHPNLQMLQARMAALDGAEACAAFGSGMAAVATALLSLVRPGDSVLHTSPLYGGTDGL 126
Query: 449 LRQVIA-RLGIN-TTFTDFTNIEKVKNAM-----QENTKMIWIETPTNPLLKVVDIEAIV 607
L V+A LG+ D + V+ A +WIETP+NPL + DI I
Sbjct: 127 LTGVMAPELGVRPVAIADALDEGSVREAAAGALAHGPLAAVWIETPSNPLAGLADIALIA 186
Query: 608 KIAR 619
++AR
Sbjct: 187 RVAR 190
>UniRef50_Q7WM51 Cluster: Cystathionase beta-lyase; n=3;
Proteobacteria|Rep: Cystathionase beta-lyase -
Bordetella bronchiseptica (Alcaligenes bronchisepticus)
Length = 408
Score = 61.3 bits (142), Expect = 2e-08
Identities = 45/168 (26%), Positives = 77/168 (45%), Gaps = 11/168 (6%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTF-------KQPAPAEHTG---FEYGRSGNPTRN 295
T +HAG++P A V P+V ++T ++ A +G F YG GNPT
Sbjct: 12 TRLLHAGKKPAYDGGAPVNPPVVRASTVIFDNVAQQRDLRARRSGERLFTYGARGNPTNF 71
Query: 296 TLEECLAALDGGKYGLTF-ASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARL 472
LE+ ++ L+G F GDH++ SD VY +L+ +A
Sbjct: 72 ALEDAVSELEGAYRTKLFPTGLAAIAMALLSYLKPGDHLLMSDAVYEPARKLVHSFLAPY 131
Query: 473 GINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
I TF + V++ ++ T+MI+ E P + + ++ D+ + +IA
Sbjct: 132 QIRCTFFAADGSD-VQDKLEPATRMIYAECPGSLVYEMCDLPRLAEIA 178
>UniRef50_A6Q4H8 Cluster: O-acetylhomoserine sulfhydrylase; n=3;
Epsilonproteobacteria|Rep: O-acetylhomoserine
sulfhydrylase - Nitratiruptor sp. (strain SB155-2)
Length = 402
Score = 61.3 bits (142), Expect = 2e-08
Identities = 36/119 (30%), Positives = 56/119 (47%), Gaps = 1/119 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTN 442
Y R GNPT LE LA +D + + AS GD + ++GG+
Sbjct: 53 YARMGNPTNAKLESILAMMDEAEGAVVTASGMGAIAMTVTSMLESGDEVACIGGLFGGSY 112
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
++ ARLGI F + K+ + TKMI+ E+ NP +++VD EA+ +A+
Sbjct: 113 AFFKETAARLGIKARFYRADELPKISS----KTKMIYCESIGNPNMQIVDFEALGMLAK 167
>UniRef50_A6PIC3 Cluster: Cystathionine beta-lyase; n=1; Shewanella
sediminis HAW-EB3|Rep: Cystathionine beta-lyase -
Shewanella sediminis HAW-EB3
Length = 411
Score = 61.3 bits (142), Expect = 2e-08
Identities = 33/118 (27%), Positives = 57/118 (48%), Gaps = 1/118 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTN 442
YGR G PT + +A L+GG + S GDH++ D Y T
Sbjct: 71 YGRRGGPTHFAFQAAIAELEGGVGTALYPSGSAAISGALLSFLKAGDHLLMVDSAYEPTR 130
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
L +++A GI TT+ D + ++ NTK++++E+P + ++V D+ + +IA
Sbjct: 131 DLCNKLLAGFGIETTYYDPMIGAGISELIRPNTKVLFLESPGSITMEVQDVPTLSEIA 188
>UniRef50_Q52811 Cluster: Putative cystathionine beta-lyase; n=35;
Proteobacteria|Rep: Putative cystathionine beta-lyase -
Rhizobium leguminosarum bv. viciae (strain 3841)
Length = 396
Score = 61.3 bits (142), Expect = 2e-08
Identities = 48/176 (27%), Positives = 74/176 (42%), Gaps = 5/176 (2%)
Frame = +2
Query: 104 MADHGFLKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQP-APAEHTG---FEYG 271
M D L Q G T H G +P ++ + P+V ++T P A A T + YG
Sbjct: 1 MKDKDSLLQNAGINTRLTHIGNDPFDYHGF-INPPVVHASTVLFPNARAMETRTQKYTYG 59
Query: 272 RSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXX-XXXXXNHGDHIVSSDDVYGGTNRL 448
G PT + L E + AL+G + S GDH + D VYG T
Sbjct: 60 TRGTPTTDALCEAIDALEGSAGTILVPSGLAAVTIPFLGFVAAGDHALVVDSVYGPTRHF 119
Query: 449 LRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
++ RLG+ + ++ + NTK++ E P + ++ DI AI +A
Sbjct: 120 CDTMLKRLGVEVEYYHPEIGAGIETLFRSNTKLVHTEAPGSNTFEMQDIPAISAVA 175
>UniRef50_Q8NM00 Cluster: Cystathionine beta-lyases/cystathionine
gamma-synthases; n=1; Corynebacterium glutamicum|Rep:
Cystathionine beta-lyases/cystathionine gamma-synthases
- Corynebacterium glutamicum (Brevibacterium flavum)
Length = 382
Score = 60.9 bits (141), Expect = 2e-08
Identities = 42/154 (27%), Positives = 67/154 (43%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALD 325
T+ + AG+ P + A + PI S+T+ + YGR GN E + LD
Sbjct: 18 TVTVQAGR-PARTPGAPMNPPITLSSTYVHDSEKA-----YGRDGNDGWGAFEAAMGTLD 71
Query: 326 GGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTN 505
GG + ++++S G +V Y G + ++ AR + D N
Sbjct: 72 GG-FAVSYSSGLAAATSIADLVPTGGTVVLPKAAYYGVTNIFARMEARGRLKVRTVDADN 130
Query: 506 IEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIV 607
E+V A Q ++W+E+ NP + V DI AIV
Sbjct: 131 TEEVIAAAQ-GADVVWVESIANPTMVVADIPAIV 163
>UniRef50_Q9X0Z7 Cluster: Cystathionine gamma-synthase; n=2;
Thermotoga|Rep: Cystathionine gamma-synthase -
Thermotoga maritima
Length = 379
Score = 60.5 bits (140), Expect = 3e-08
Identities = 33/120 (27%), Positives = 59/120 (49%), Gaps = 1/120 (0%)
Frame = +2
Query: 260 FEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGG 436
F Y R NPT +E+ LAAL+ + AS + GDH+V D+ Y
Sbjct: 49 FVYKRGSNPTTRLVEKKLAALEECEDARLVASGMSAISLSILHFLSSGDHVVCVDEAYSW 108
Query: 437 TNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+ + + I ++ + E++ A+ + TK+I++E+PT+ +KV+DI + + A
Sbjct: 109 AKKFFNYLSKKFDIEVSYVP-PDAERIVEAITKKTKLIYLESPTSMRMKVIDIRKVTEAA 167
>UniRef50_A7CL93 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzyme; n=1; Ralstonia
pickettii 12D|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzyme - Ralstonia
pickettii 12D
Length = 385
Score = 60.1 bits (139), Expect = 4e-08
Identities = 32/121 (26%), Positives = 61/121 (50%), Gaps = 1/121 (0%)
Frame = +2
Query: 257 GFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXX-XXXXXNHGDHIVSSDDVYG 433
G+ YG G PT LE +A+++GG + S + GDH++ +D VYG
Sbjct: 47 GYSYGLYGTPTTRALETEVASIEGGSRTVLVPSGLAALTHPMLALLSAGDHVLVADCVYG 106
Query: 434 GTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
T V+ ++G+ T+ + + +Q NT+++ +E+P + +++ +I AI +
Sbjct: 107 PTREFCNSVLRKIGVAVTYF-AADAATIDAHLQSNTRLVLLESPGSFTMEIQEIAAISRE 165
Query: 614 A 616
A
Sbjct: 166 A 166
>UniRef50_Q1NS60 Cluster: O-acetylhomoserine
aminocarboxypropyltransferase; n=3; Bacteria|Rep:
O-acetylhomoserine aminocarboxypropyltransferase - delta
proteobacterium MLMS-1
Length = 415
Score = 59.3 bits (137), Expect = 7e-08
Identities = 36/119 (30%), Positives = 57/119 (47%), Gaps = 1/119 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFAS-XXXXXXXXXXXXNHGDHIVSSDDVYGGTN 442
Y R NPT E + AL GG+ + AS G +IV+ ++G T
Sbjct: 56 YTRISNPTVAEFERRVQALAGGRGVVAQASGMAAITTTILALAGAGSNIVAGRSLFGNTV 115
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
LL + + G+ T F + + V A+ NT I++E+ TNP L+V D+ A+ + A+
Sbjct: 116 SLLARTLKPWGLETRFVEMKDQAAVAAAIDHNTAAIFLESITNPRLEVCDLPALAEFAQ 174
>UniRef50_A0JYV8 Cluster: Cystathionine gamma-synthase; n=8;
Actinobacteria (class)|Rep: Cystathionine gamma-synthase
- Arthrobacter sp. (strain FB24)
Length = 387
Score = 59.3 bits (137), Expect = 7e-08
Identities = 38/127 (29%), Positives = 62/127 (48%), Gaps = 2/127 (1%)
Frame = +2
Query: 242 PAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNHGD--HIVS 415
P E Y R NPT EE +A L+G + FA+ H+V+
Sbjct: 53 PLEGQSTVYQRLWNPTVARFEEGVAVLEGAPEAVAFATGMAALSAVLLATVAAGRKHVVA 112
Query: 416 SDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDI 595
+YGG++ +L + LG TFT + V++A++ +T ++ +ETP NP L++VDI
Sbjct: 113 VRPLYGGSDHILASGV--LGTEVTFT---TADGVRDALRPDTGLVIVETPANPSLELVDI 167
Query: 596 EAIVKIA 616
+ + A
Sbjct: 168 AQLARDA 174
>UniRef50_Q4Q511 Cluster: Cystathionine beta-lyase, putative; n=3;
Leishmania|Rep: Cystathionine beta-lyase, putative -
Leishmania major
Length = 399
Score = 59.3 bits (137), Expect = 7e-08
Identities = 45/163 (27%), Positives = 76/163 (46%), Gaps = 9/163 (5%)
Frame = +2
Query: 158 HAGQEP-EKWNSAAVVTPIVTSTT--FKQ--PAPAEHTGFEYGRSGNPTRNTLEECLAAL 322
H G+ P E+W + PI +T +K A + + YG +GNPT L+ AL
Sbjct: 17 HVGRNPDEQWGF--INCPIYRGSTVLYKSINDALKLRSVYWYGTAGNPTVTNLQNAWTAL 74
Query: 323 DGGKYGLTFASXXXXXXXXX-XXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTD- 496
GG + +S N GD+I+ +D VY T L + GI TT+ D
Sbjct: 75 TGGAGSVVVSSGMQAIAYALLATANSGDNILVADAVYLPTRNLCDHFLVTKGITTTYYDP 134
Query: 497 FTNIEKVKNAMQE--NTKMIWIETPTNPLLKVVDIEAIVKIAR 619
++++ + + NT +I++E+P + ++ D+ I +AR
Sbjct: 135 CITADELRELLHQKPNTTVIFMESPGSQTFEIQDVPMICAVAR 177
>UniRef50_Q07703 Cluster: Cystathionine beta-lyase; n=6;
Burkholderiales|Rep: Cystathionine beta-lyase -
Bordetella avium
Length = 396
Score = 59.3 bits (137), Expect = 7e-08
Identities = 34/119 (28%), Positives = 61/119 (51%), Gaps = 1/119 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYG-LTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTN 442
YGR G T LE+ A L+GG + L + + G+H + +D YG +
Sbjct: 64 YGRMGMDTHAALEQVFAELEGGTHCYLASSGLAGISMVFLSLLSAGEHALVADCAYGPVH 123
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
L V++RLGI+ TF D + + ++ T++I+ E P + L +++D+ A+ + A+
Sbjct: 124 ELHEAVLSRLGIDVTFFDAK--ADLASLVRPTTRLIFAEAPGSLLFEMLDMPALARFAK 180
>UniRef50_Q5GSE3 Cluster: Cystathionine beta-lyase; n=5;
Wolbachia|Rep: Cystathionine beta-lyase - Wolbachia sp.
subsp. Brugia malayi (strain TRS)
Length = 413
Score = 58.4 bits (135), Expect = 1e-07
Identities = 35/121 (28%), Positives = 56/121 (46%), Gaps = 1/121 (0%)
Frame = +2
Query: 260 FEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGG 436
+ YG G PT + LA ++G L + S G H++ D+ Y
Sbjct: 60 YSYGSVGTPTVHYFSNALAEIEGRGQALIYPSGLFALTFAILTFARAGSHVLIQDNSYYR 119
Query: 437 TNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
R + + + TF D T + + + +Q NT++I IETP + +V +IE IVKIA
Sbjct: 120 LRRFAENELPKRRVEVTFYDPT--QDIASLIQSNTRLIMIETPGSVTFEVSNIEHIVKIA 177
Query: 617 R 619
+
Sbjct: 178 K 178
>UniRef50_Q3A8R5 Cluster: O-acetylhomoserine/O-acetylserine
sulfhydrylase; n=1; Carboxydothermus hydrogenoformans
Z-2901|Rep: O-acetylhomoserine/O-acetylserine
sulfhydrylase - Carboxydothermus hydrogenoformans
(strain Z-2901 / DSM 6008)
Length = 400
Score = 58.4 bits (135), Expect = 1e-07
Identities = 34/122 (27%), Positives = 55/122 (45%), Gaps = 1/122 (0%)
Frame = +2
Query: 257 GFEYGRSGNPTRNTLEECLAALDGGKYGL-TFASXXXXXXXXXXXXNHGDHIVSSDDVYG 433
GF Y R NPT LEE +A L+GG T + G + ++G
Sbjct: 39 GFFYSRVANPTVAALEEKVARLEGGVMATATSSGMAAIALTFMAFAQPGAEFLVCAGLFG 98
Query: 434 GTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
GT LL+ + GI + E VK + +T+++++E+ NP LK+ D +V +
Sbjct: 99 GTLNLLKNLTKTCGITYKLLPAPDPELVKKHLTSSTRLVFVESIGNPTLKIPDFAGLVSL 158
Query: 614 AR 619
+
Sbjct: 159 LK 160
>UniRef50_A1W861 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=10; cellular
organisms|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Acidovorax sp.
(strain JS42)
Length = 415
Score = 58.0 bits (134), Expect = 2e-07
Identities = 40/155 (25%), Positives = 67/155 (43%), Gaps = 1/155 (0%)
Frame = +2
Query: 158 HAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKY 337
HA Q P ++ V+ P V + ++ + + + YG G PT LEE LA L+GG
Sbjct: 25 HAPQ-PAVHKASTVIFPNVAAMRAREWK--DKSSYTYGLHGTPTTYQLEERLATLEGGLQ 81
Query: 338 GLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEK 514
L S GD ++ D+ YG L + GI D +
Sbjct: 82 CLLVPSGLAAISTVSLALLRQGDEVLIPDNAYGPNKALAEVELRHYGIRHRIYDPLDPAD 141
Query: 515 VKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ + + + T+++W+E P + L+ D+ V+I R
Sbjct: 142 LASKITDATRLVWLEAPGSVTLEFPDLVEQVRICR 176
>UniRef50_P44527 Cluster: Cystathionine beta-lyase; n=78;
Gammaproteobacteria|Rep: Cystathionine beta-lyase -
Haemophilus influenzae
Length = 396
Score = 58.0 bits (134), Expect = 2e-07
Identities = 32/119 (26%), Positives = 56/119 (47%), Gaps = 1/119 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTF-ASXXXXXXXXXXXXNHGDHIVSSDDVYGGTN 442
YGR G T L++ + ++GG + GDH++ S Y T
Sbjct: 57 YGRRGTLTHFALQDLMCEMEGGAGCYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQ 116
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
V+ ++ I+ T+ D E + +Q NTK++++E P++ +++ DI IVK AR
Sbjct: 117 YFCNIVLKKMQIDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITMEIPDIPTIVKAAR 175
>UniRef50_Q98LV9 Cluster: Methionine gamma lyase; n=4;
Rhizobiales|Rep: Methionine gamma lyase - Rhizobium loti
(Mesorhizobium loti)
Length = 395
Score = 57.2 bits (132), Expect = 3e-07
Identities = 48/179 (26%), Positives = 82/179 (45%), Gaps = 9/179 (5%)
Frame = +2
Query: 110 DHGFLKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTG-FE------- 265
DH +L + AT+ H E + AVV PI ++ F AE F
Sbjct: 9 DHDYLAEA---ATLLAH----DEPFPGGAVVPPIYQTSLFTFANYAEMADTFAGKRKQPI 61
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFAS-XXXXXXXXXXXXNHGDHIVSSDDVYGGTN 442
Y R NPT E +AAL+G + F+S G+ IV+ + YG
Sbjct: 62 YSRGDNPTVMEFEARVAALEGAEAARGFSSGMAAISATVLAFVGAGERIVAVRNCYGDAY 121
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
RL +++ RL I + D ++ + V A+ K++++E+PT+ + ++ DI + ++A+
Sbjct: 122 RLFERLLPRLNIKVDYVDGSDPDAVAAAL-PGAKLLYLESPTSMMFELQDIAHLTRLAK 179
>UniRef50_A3X9V5 Cluster: Cystathionine gamma-synthase; n=12;
Rhodobacteraceae|Rep: Cystathionine gamma-synthase -
Roseobacter sp. MED193
Length = 390
Score = 57.2 bits (132), Expect = 3e-07
Identities = 45/156 (28%), Positives = 69/156 (44%), Gaps = 3/156 (1%)
Frame = +2
Query: 143 ATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAE--HTGFEYGRSGNPTRNTLEECLA 316
ATIA A + S VV P+ STTF + + + Y RS N EE L+
Sbjct: 19 ATIAAQAAGTIDA-ASGGVVPPLQPSTTFVRDRDYQLVNESNVYLRSHNEAVRLGEEILS 77
Query: 317 ALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTD 496
L+G + F S +G ++ +Y GT + +R R I D
Sbjct: 78 RLEGAEDTQLFPSGMAAIAAVFRTVPNGGAVIVQSGIYWGTTKWIRDFCTRRDIALHEVD 137
Query: 497 FTNIEKVKNAMQ-ENTKMIWIETPTNPLLKVVDIEA 601
++I ++ ++++IETP+NP LK VDI+A
Sbjct: 138 ASDIGALQAVCAVHQAQLLFIETPSNPWLKTVDIKA 173
>UniRef50_Q979X4 Cluster: Cystathionine beta lyase /
O-succinylhomoserine lyase; n=3; Thermoplasma|Rep:
Cystathionine beta lyase / O-succinylhomoserine lyase -
Thermoplasma volcanium
Length = 368
Score = 57.2 bits (132), Expect = 3e-07
Identities = 31/120 (25%), Positives = 58/120 (48%), Gaps = 1/120 (0%)
Frame = +2
Query: 260 FEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGG 436
+ Y R NPT L L+ L+ + + F+S GD +V DV+G
Sbjct: 32 YRYSRELNPTVEELSRQLSLLENTERSICFSSGMGAITGTILALAKPGDKLVMPTDVFGR 91
Query: 437 TNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
T + + + GIN F + + + A++E+ +++ E+ +NPLL++ D++ I + A
Sbjct: 92 TYLFAKNFLTKFGINVKFVE-PGTDSLLGAVEEHADIVFFESLSNPLLRLYDVDRICRKA 150
>UniRef50_Q6MN74 Cluster: Cys/Met metabolism lyase; n=1;
Bdellovibrio bacteriovorus|Rep: Cys/Met metabolism lyase
- Bdellovibrio bacteriovorus
Length = 426
Score = 56.4 bits (130), Expect = 5e-07
Identities = 33/135 (24%), Positives = 65/135 (48%), Gaps = 2/135 (1%)
Frame = +2
Query: 221 TTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFAS-XXXXXXXXXXXXNH 397
+TF E + Y R PT LE+ LA L+ G+ +TF S +
Sbjct: 55 STFGAQKGEEKPIWIYDRLEEPTTKMLEDQLALLEKGECAVTFGSGMGAIASTLMSLLSS 114
Query: 398 GDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQE-NTKMIWIETPTNP 574
G +++ +YG T LL + RL I+T D + + ++ + + ++++ E+ +NP
Sbjct: 115 GQKVIAHKTLYGCTYSLLTNWLPRLNISTHLMDVNDFKNLELQLADPAARVVYFESVSNP 174
Query: 575 LLKVVDIEAIVKIAR 619
+L++ D++ I + +
Sbjct: 175 ILEIADLQKITALVK 189
>UniRef50_Q62JZ5 Cluster: Cystathionine beta-lyase; n=37;
Burkholderiales|Rep: Cystathionine beta-lyase -
Burkholderia mallei (Pseudomonas mallei)
Length = 394
Score = 56.4 bits (130), Expect = 5e-07
Identities = 32/121 (26%), Positives = 54/121 (44%), Gaps = 1/121 (0%)
Frame = +2
Query: 260 FEYGRSGNPTRNTLEECLAALDGGKYGLTFASXX-XXXXXXXXXXNHGDHIVSSDDVYGG 436
+ YG PT L + LA ++GG + L S GD ++ D+ YG
Sbjct: 57 WRYGLHATPTSLALAQRLAEIEGGAHALLQPSGLCAITNVYFGLVKEGDDVLIPDNAYGP 116
Query: 437 TNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+ + GI F D + + +Q NT+++W+E P + ++V D+ AI +A
Sbjct: 117 NGDFGKWLAKDFGITARFYDPMIGAGIADLIQPNTRIVWLEAPGSVTMEVPDVRAITAVA 176
Query: 617 R 619
R
Sbjct: 177 R 177
>UniRef50_Q98K64 Cluster: Methionine gamma-lyase; n=13;
Bacteria|Rep: Methionine gamma-lyase - Rhizobium loti
(Mesorhizobium loti)
Length = 427
Score = 56.0 bits (129), Expect = 7e-07
Identities = 40/136 (29%), Positives = 61/136 (44%), Gaps = 7/136 (5%)
Frame = +2
Query: 230 KQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFAS-XXXXXXXXXXXXNHGDH 406
K+P +G Y R +P +E+ LA +G + F+S GD
Sbjct: 65 KEPPSGTASGLVYSRFNHPNSEIVEDRLAIYEGTDACILFSSGMSAIATTLLAYARPGDV 124
Query: 407 IVSSDDVYGGTNRLLRQVIARLGINTT-FTDFTNIEKVKNA-----MQENTKMIWIETPT 568
I+ S +YGGT LL + ++ GI F D + + V+ A + +I IETP+
Sbjct: 125 ILHSQPLYGGTETLLTRTLSGFGIGAVGFADGVDEKAVRAAADAAVAKGRVSVILIETPS 184
Query: 569 NPLLKVVDIEAIVKIA 616
NP +VDI + IA
Sbjct: 185 NPTNSLVDIALMRMIA 200
>UniRef50_Q7W586 Cluster: Cystathionine beta-lyase; n=3;
Bordetella|Rep: Cystathionine beta-lyase - Bordetella
parapertussis
Length = 413
Score = 56.0 bits (129), Expect = 7e-07
Identities = 41/168 (24%), Positives = 76/168 (45%), Gaps = 9/168 (5%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTT--------FKQPAPAEHTGFEYGRSGNPTRN 295
F T+ H G++P K + V TP+ ++T +K A+ YGR G T
Sbjct: 33 FDTLLTHGGRDP-KAHKGMVNTPVYRTSTVVFESMAEYKATRGAKFDHVRYGRLGTHTVK 91
Query: 296 TLEECLAALDGG-KYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARL 472
LE +AA++GG + LT + G HI+ D+VY +V+A
Sbjct: 92 ELENLVAAIEGGHRAVLTPSGVSAIATTLNTLARPGSHILVPDNVYYPCREFCEKVLAPR 151
Query: 473 GINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
G+ + + +E++ ++ +T +++ E+P + +++ D I A
Sbjct: 152 GVRVEYYAGSEVERL---VRPDTSVVYCESPGSLTMEMQDFARIAAAA 196
>UniRef50_A6QZA3 Cluster: Cystathionine gamma-lyase; n=1;
Ajellomyces capsulatus NAm1|Rep: Cystathionine
gamma-lyase - Ajellomyces capsulatus NAm1
Length = 457
Score = 55.6 bits (128), Expect = 9e-07
Identities = 30/69 (43%), Positives = 40/69 (57%), Gaps = 1/69 (1%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTG-FEYGRSGNPTRNTLEECLA 316
F T A+HAG + + AV+ PI STTF Q + G +EY RS NP R+ EE +A
Sbjct: 108 FGTRAVHAGAHVDA-TTGAVIAPISLSTTFAQVGVGKPIGQYEYTRSANPNRDHFEEAVA 166
Query: 317 ALDGGKYGL 343
AL+ +Y L
Sbjct: 167 ALEHARYAL 175
>UniRef50_Q6L1U0 Cluster: Cystathionine beta-lyase; n=1; Picrophilus
torridus|Rep: Cystathionine beta-lyase - Picrophilus
torridus
Length = 364
Score = 55.2 bits (127), Expect = 1e-06
Identities = 36/139 (25%), Positives = 62/139 (44%), Gaps = 1/139 (0%)
Frame = +2
Query: 197 VVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXX 376
+V PI + +++ P + F Y R NPT L + L+ G +F+S
Sbjct: 14 LVFPIYQTGSYEIPGGEK---FRYSREYNPTVENLNNVIKRLEHGDLANSFSSGMGAITT 70
Query: 377 XXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIW 553
GD V+ D + + + + GI T + E + + + TK+++
Sbjct: 71 TLLSILRPGDEAVTHIDTFARSYHFFSEFLRSFGIKTRISR-PGTENILEEINKRTKLVF 129
Query: 554 IETPTNPLLKVVDIEAIVK 610
IET +NP+L+V DI+ I K
Sbjct: 130 IETLSNPVLRVYDIDEISK 148
>UniRef50_Q59829 Cluster: Putative cystathionine gamma-lyase; n=8;
Actinomycetales|Rep: Putative cystathionine gamma-lyase
- Streptomyces coelicolor
Length = 392
Score = 55.2 bits (127), Expect = 1e-06
Identities = 53/167 (31%), Positives = 73/167 (43%), Gaps = 6/167 (3%)
Frame = +2
Query: 134 PGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTG-FEYGRSGNPTRNTLEEC 310
PG T A+ AG PE + V + F P + TG + YGR NPT LE
Sbjct: 21 PGDGTRAVRAGL-PEPVKHEPTLPGPVFAAHFH--LPGDPTGPYTYGRDENPTWTRLESA 77
Query: 311 LAALDG-GKYG---LTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLG 475
+ L+ G+ G L FAS GD V DD Y L+R + G
Sbjct: 78 IGELEAPGEAGVETLVFASGMAAISSVLFSQLRAGDTAVLPDDGYQALP-LVRAQLEAYG 136
Query: 476 INTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
I T T + + + + K++WIETP+NP L V D+ +V+ A
Sbjct: 137 IEVR-TAPTGRDAQLDVL-DGAKLLWIETPSNPGLDVCDVRRLVEAA 181
>UniRef50_Q1QM61 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=1; Nitrobacter
hamburgensis X14|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Nitrobacter
hamburgensis (strain X14 / DSM 10229)
Length = 375
Score = 54.8 bits (126), Expect = 2e-06
Identities = 38/136 (27%), Positives = 58/136 (42%), Gaps = 7/136 (5%)
Frame = +2
Query: 230 KQPAPAEHTGFEYGRSGNPTRNTLEECLAALDG-GKYGLTFASXXXXXXXXXXXXNHGDH 406
++P + G Y R +P +E+ + + K L + GD
Sbjct: 64 REPPEGQGAGLVYSRFNHPNSEIVEDRFSVYERTDKCALFSSGMSAIATTILAFVRPGDV 123
Query: 407 IVSSDDVYGGTNRLLRQVIARLGINTT-FTDFTNIEKVKNAMQENTK-----MIWIETPT 568
I+ S +YGGT L + +A L IN F D + V Q+ T+ MI+ ETP
Sbjct: 124 ILHSQPLYGGTETLFAKTLAGLSINAVGFADGVDEAAVSAVAQDATRKGRVAMIFTETPA 183
Query: 569 NPLLKVVDIEAIVKIA 616
NP +VDI + +IA
Sbjct: 184 NPTNSLVDIAMVRRIA 199
>UniRef50_Q1DAY0 Cluster: Cys/Met metabolism PLP-dependent enzyme;
n=2; Cystobacterineae|Rep: Cys/Met metabolism
PLP-dependent enzyme - Myxococcus xanthus (strain DK
1622)
Length = 394
Score = 54.8 bits (126), Expect = 2e-06
Identities = 42/163 (25%), Positives = 68/163 (41%), Gaps = 8/163 (4%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTT--FKQP----APAEHTGFEYGRSGNPTRNTLEE 307
T+A+HAG + V PI + F + + + Y R P LEE
Sbjct: 7 TVAVHAGTRLAGSKAVPVSPPIYPAAVNWFDSSDDLDSALDGKDYAYARISAPNTTLLEE 66
Query: 308 CLAALDGGKYGLTFASXXXXXXXXXXXXNH--GDHIVSSDDVYGGTNRLLRQVIARLGIN 481
+AAL+G + + +AS GD +V D YG T L + + A LG+
Sbjct: 67 AVAALEGAEDCVAYASGMAALRSVFEAQGFRAGDKLVMPADGYGVTRALYKSLCATLGVE 126
Query: 482 TTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVK 610
T+ E + +M+ E+ +NPLL+V D+ + +
Sbjct: 127 LHAFLMTDPEVPERIRALKPRMVLAESISNPLLRVPDLRVLAR 169
>UniRef50_Q5PBE9 Cluster: Cystathionine beta-lyase; n=1; Anaplasma
marginale str. St. Maries|Rep: Cystathionine beta-lyase
- Anaplasma marginale (strain St. Maries)
Length = 408
Score = 54.4 bits (125), Expect = 2e-06
Identities = 34/119 (28%), Positives = 57/119 (47%), Gaps = 1/119 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFASXXX-XXXXXXXXXNHGDHIVSSDDVYGGTN 442
YG P+ +L E + A+DGGKY L F S + G HI+ Y +
Sbjct: 75 YGNIAAPSCTSLAEDVRAIDGGKYALLFPSGLLCLTMACVTFCDAGSHILVPKKAYFKLH 134
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
R +++ RLG + + + + E V E T +I+IET ++ L + D+ I++ A+
Sbjct: 135 RFIQESCPRLGRSVSV--YESAEDVPKMANEKTSLIFIETLSSSRLIIEDVSPIIEFAK 191
>UniRef50_Q1GVW8 Cluster: Cystathionine gamma-lyase; n=15;
Bacteria|Rep: Cystathionine gamma-lyase - Sphingopyxis
alaskensis (Sphingomonas alaskensis)
Length = 430
Score = 54.0 bits (124), Expect = 3e-06
Identities = 44/155 (28%), Positives = 70/155 (45%), Gaps = 14/155 (9%)
Frame = +2
Query: 182 WNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFAS-X 358
+ SAA T K+ PA+ G Y R P + LE+ LA DG L F+S
Sbjct: 51 FESAAAGKRFFEHITGKREGPAD--GLVYSRFNGPNQEILEDRLAVWDGADDSLVFSSGM 108
Query: 359 XXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDF------TNIEKV- 517
D IV S +Y T L+ ++++R G+ +F DF +I+ +
Sbjct: 109 SAIATLLLALVGQNDVIVHSGPLYAATETLIARILSRFGV--SFVDFPAGASRDDIDVIL 166
Query: 518 ----KNAMQENTK--MIWIETPTNPLLKVVDIEAI 604
A Q+ K ++++E+P NP +VD+EA+
Sbjct: 167 ARAQALASQKGGKVALVYLESPANPTNALVDVEAV 201
>UniRef50_Q0APK0 Cluster: Cystathionine beta-lyase; n=1; Maricaulis
maris MCS10|Rep: Cystathionine beta-lyase - Maricaulis
maris (strain MCS10)
Length = 385
Score = 54.0 bits (124), Expect = 3e-06
Identities = 31/119 (26%), Positives = 55/119 (46%), Gaps = 1/119 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGK-YGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTN 442
YGR G T + L L L GG LT + G ++++D +YG
Sbjct: 48 YGRVGLETHDALRGALTELQGGAGCALTSSGLMANTLSILAATEAGGEVLAADCIYGPVR 107
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
L ++R G+ T F ++ + + + T+ I +E+P + +++ D+ AI K+AR
Sbjct: 108 NFLTTQMSRYGVRTRFFAPQMGAEIGDLITDETQAILLESPGSLTMEMQDVPAIAKVAR 166
>UniRef50_A0H5P3 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=3; Chloroflexi
(class)|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Chloroflexus
aggregans DSM 9485
Length = 373
Score = 54.0 bits (124), Expect = 3e-06
Identities = 46/158 (29%), Positives = 64/158 (40%), Gaps = 5/158 (3%)
Frame = +2
Query: 161 AGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRS-----GNPTRNTLEECLAALD 325
+G + W AA T ++ P PA + GRS PT LEE + L+
Sbjct: 6 SGLKLASWLVAAGRTVDPGASLNVPPIPASNFILGQGRSYARGDSTPTWEALEEVIGGLE 65
Query: 326 GGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTN 505
GK + FAS G +V DD Y G L AR + T+
Sbjct: 66 AGK-AVAFASGMAAVAAIFDQLPSGARVVLPDDCYQGVVGLAMAGAARGRWSVQRIALTD 124
Query: 506 IEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
+ A E +IW+E+P+NPLL V D++ I R
Sbjct: 125 TAAWQQACTE-ADLIWLESPSNPLLTVADLDVICAAPR 161
>UniRef50_Q6F7Q9 Cluster: Putative cystathionine beta-lyase,
PLP-dependent; n=1; Acinetobacter sp. ADP1|Rep: Putative
cystathionine beta-lyase, PLP-dependent - Acinetobacter
sp. (strain ADP1)
Length = 397
Score = 53.6 bits (123), Expect = 4e-06
Identities = 39/156 (25%), Positives = 72/156 (46%), Gaps = 1/156 (0%)
Frame = +2
Query: 155 IHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGK 334
IH+ Q P + ++ ++ P T+ F + ++ + YG G PT TL + LA ++GG+
Sbjct: 22 IHSIQPP-LFRASTIIFP-TTAHLFDRHW-SDPYDYSYGTHGTPTTFTLGDQLAEIEGGQ 78
Query: 335 YGLTFAS-XXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIE 511
Y L S +HGD + D++YG L + R GI + I+
Sbjct: 79 YCLLAPSGLSAINLVNSTFLSHGDEVWVPDNIYGPNMEHLNNLRQRYGIQVRI--YNPID 136
Query: 512 KVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
E T+++W+E + ++ D+ +V+ A+
Sbjct: 137 AESFIPSEKTRLLWLEAAGSITMEFPDLIQLVRKAQ 172
>UniRef50_Q11MH2 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=1;
Mesorhizobium sp. BNC1|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Mesorhizobium
sp. (strain BNC1)
Length = 407
Score = 53.6 bits (123), Expect = 4e-06
Identities = 37/161 (22%), Positives = 69/161 (42%), Gaps = 1/161 (0%)
Frame = +2
Query: 137 GFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLA 316
GFA++A+ + ++ +V P +S F+ + G+ YG G PT TLE ++
Sbjct: 17 GFASLAVPVTR------ASTIVFP--SSDAFESRYEHFYDGYTYGLYGTPTSRTLEARIS 68
Query: 317 ALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFT 493
L + L S GD ++ + YG T +++A G+
Sbjct: 69 ELYAADHCLCLPSGQSATVLALSALLKAGDRVLVTTSAYGSTRTFCTEMLAAFGVEVALY 128
Query: 494 DFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
D + + + T+M+ +E+P + +++ DI AI A
Sbjct: 129 DPGVASGIGAFLDDRTRMVVVESPGSNTMEIQDIPAIAHAA 169
>UniRef50_Q1V2M7 Cluster: Cystathionine beta-lyase; n=2; Candidatus
Pelagibacter ubique|Rep: Cystathionine beta-lyase -
Candidatus Pelagibacter ubique HTCC1002
Length = 391
Score = 52.8 bits (121), Expect = 6e-06
Identities = 30/121 (24%), Positives = 55/121 (45%), Gaps = 1/121 (0%)
Frame = +2
Query: 260 FEYGRSGNPTRNTLEECLAALDGGKYG-LTFASXXXXXXXXXXXXNHGDHIVSSDDVYGG 436
F+YGR G T + L + L ++ + LT GD I+ +D Y
Sbjct: 55 FDYGRQGTSTTHVLSQILKEMEECYHVFLTPTGFGSVFLSIFSIVRPGDEIIVADPTYSP 114
Query: 437 TNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
T L + + + + F D +++ ++ A+ + TK+I++E P + D+ IV IA
Sbjct: 115 TRILTQDFLKEFNVKSVFYDPHDLKTLEKAITKKTKLIFVENPGSNTFDFQDLGKIVSIA 174
Query: 617 R 619
+
Sbjct: 175 K 175
>UniRef50_A6GJL1 Cluster: Methionine gamma-lyase; n=1; Plesiocystis
pacifica SIR-1|Rep: Methionine gamma-lyase -
Plesiocystis pacifica SIR-1
Length = 399
Score = 52.8 bits (121), Expect = 6e-06
Identities = 45/180 (25%), Positives = 73/180 (40%), Gaps = 16/180 (8%)
Frame = +2
Query: 122 LKQKPGFATIAIHAGQEPEKWNSAAVVTPIVT-STTFKQPAP---AEHTGFE------YG 271
+ ++P +T+ IH G E + P + STTF P A TG YG
Sbjct: 1 MARRPALSTMLIHPGHADETAATRHGSAPAIERSTTFPLDQPRVDAMVTGQGLRQADVYG 60
Query: 272 RSGNPTRNTLEECLAALDGGKY-GLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRL 448
R G T + +A L+G + LT + G + ++ VYGGT +
Sbjct: 61 RFGTSTGRVAADLIARLEGAEACALTASGMAAITTTLTTLVPAGGRVACAEVVYGGTESV 120
Query: 449 LRQVIARLGINTTFTDFTNIEKVKNAM-----QENTKMIWIETPTNPLLKVVDIEAIVKI 613
LR + G+ D E + + Q ++W E+ NPL+++ I AI ++
Sbjct: 121 LRHELEPRGVRCDRFDARRPETLAPLLDPPPGQAKPDLVWCESIANPLMRIGQISAIARL 180
>UniRef50_A3VUE2 Cluster: Cystathionine beta-lyase; n=1;
Parvularcula bermudensis HTCC2503|Rep: Cystathionine
beta-lyase - Parvularcula bermudensis HTCC2503
Length = 381
Score = 52.0 bits (119), Expect = 1e-05
Identities = 34/123 (27%), Positives = 54/123 (43%), Gaps = 2/123 (1%)
Frame = +2
Query: 245 AEHTGFEYGRSGNPTRNTLEECLAALDGG-KYGLTFASXXXXXXXXXXXXNHGDHIVSSD 421
A + YGR+G PT LEE L L+G LT + G H++ +D
Sbjct: 40 ANRPPWHYGRTGTPTHRALEESLCDLEGADNVVLTGSGLEACTLAILSCVTAGGHVLVTD 99
Query: 422 DVYGGTNRLLRQVIARLGINTTFTD-FTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIE 598
Y T ++ I TT+ D E++ + T++I+ E+P + +V D+
Sbjct: 100 SAYEPTRTFCDGLLRGFDIETTYFDPQAGREEIAALCRPTTQLIFCESPGSLTFEVQDLP 159
Query: 599 AIV 607
AIV
Sbjct: 160 AIV 162
>UniRef50_A3PXR9 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes; n=7;
Actinomycetales|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzymes - Mycobacterium
sp. (strain JLS)
Length = 367
Score = 52.0 bits (119), Expect = 1e-05
Identities = 40/139 (28%), Positives = 56/139 (40%), Gaps = 1/139 (0%)
Frame = +2
Query: 206 PIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFAS-XXXXXXXXX 382
P+ S P A+ YGRS NPT LE LA L+G L F S
Sbjct: 29 PVPVSAYHLSPDEAQPLD-TYGRSSNPTWRRLEAALAELEGASAALAFGSGMAAITSALR 87
Query: 383 XXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIET 562
G+ +V D Y R + +A G+ T + E + A + ++ ET
Sbjct: 88 VLTGPGERLVVPADGYYQVRRYAAEYLAPQGV--TVLEVATAEMCEAA--ADADVVLAET 143
Query: 563 PTNPLLKVVDIEAIVKIAR 619
P NP L+VVD+ + R
Sbjct: 144 PANPGLEVVDLHRLAMTCR 162
>UniRef50_Q13Z52 Cluster: Cystathionine beta-lyase; n=2;
Burkholderia|Rep: Cystathionine beta-lyase -
Burkholderia xenovorans (strain LB400)
Length = 394
Score = 51.6 bits (118), Expect = 1e-05
Identities = 33/122 (27%), Positives = 58/122 (47%), Gaps = 2/122 (1%)
Frame = +2
Query: 260 FEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGG 436
+ YG PT L + LA ++GG + L S GD ++ D+VY
Sbjct: 57 WRYGLHATPTSLALAQRLATIEGGNHALLQPSGLSSISNVYFGLVKAGDDVLIPDNVYS- 115
Query: 437 TNRLLRQVIAR-LGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
NR +AR G++ + + + + ++ NT++IW+E P + ++V D+ AI +
Sbjct: 116 PNRDHGDWLARDFGVSVRYYNPMIGAGIADLIRPNTRLIWLEAPGSVTMEVADVPAITAV 175
Query: 614 AR 619
AR
Sbjct: 176 AR 177
>UniRef50_A7HB44 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent protein; n=2;
Anaeromyxobacter|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent protein - Anaeromyxobacter
sp. Fw109-5
Length = 363
Score = 51.6 bits (118), Expect = 1e-05
Identities = 48/158 (30%), Positives = 68/158 (43%)
Frame = +2
Query: 146 TIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALD 325
T+A+HA E+ ++ V PI STTF A + G Y R PTR LE L ALD
Sbjct: 14 TLALHADAGVER--TSDVAPPIHVSTTF---AAGDDEGLVYARQDQPTRRRLEAVLGALD 68
Query: 326 GGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTN 505
GG + +TFAS + + Y T+ + +A GI
Sbjct: 69 GG-HAVTFASGQAAATAALLHL-RPRRVAIAPGGYHLTHAAI-DALAPCGIE-------- 117
Query: 506 IEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
E +A ++W+ETP NP ++ DI + AR
Sbjct: 118 -EVPLDAEVGAGDVVWLETPKNPTCELQDIASHAARAR 154
>UniRef50_Q67LU9 Cluster: Cystathionine beta-lyase; n=2;
Bacteria|Rep: Cystathionine beta-lyase - Symbiobacterium
thermophilum
Length = 75
Score = 51.2 bits (117), Expect = 2e-05
Identities = 26/62 (41%), Positives = 35/62 (56%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAA 319
F T +H G+E + AA V PI +TF+QP ++Y RSGNPTR LE +A
Sbjct: 3 FGTRVLHTGREVDSVTGAAAV-PIYQVSTFRQPGLNRSGPYDYARSGNPTRQALEAIVAD 61
Query: 320 LD 325
L+
Sbjct: 62 LE 63
>UniRef50_Q83WD5 Cluster: Putative cystathionine/methionine
gamma-synthase/lyase; n=1; Streptomyces griseus|Rep:
Putative cystathionine/methionine gamma-synthase/lyase -
Streptomyces griseus
Length = 189
Score = 50.8 bits (116), Expect = 3e-05
Identities = 49/165 (29%), Positives = 72/165 (43%), Gaps = 5/165 (3%)
Frame = +2
Query: 137 GFATIAIHAG-QEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECL 313
G T A+ AG EPE++ + P+ + P + YGR NPT LE +
Sbjct: 21 GDGTRAVRAGLPEPEQFGPT-LPGPVFAAHFHLSGEPVGP--YTYGRETNPTWTHLERAI 77
Query: 314 AALD--GGKYGLT-FASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGIN 481
L+ G + G T FAS GD +V DD Y L+R+ + G+
Sbjct: 78 GELEAPGEEVGTTVFASGMAAITAVLLSQVRSGDAVVLPDDGYQALP-LVREQLEAYGVE 136
Query: 482 TTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
T T + + A+ K++WIE+P+NP L V DI + A
Sbjct: 137 VR-TAPTGGD-AQQALLTGAKLLWIESPSNPGLDVCDIRRLAGAA 179
>UniRef50_A7H1V2 Cluster: Cystathionine beta-lyase; n=15;
Campylobacter|Rep: Cystathionine beta-lyase -
Campylobacter jejuni subsp. doylei 269.97
Length = 387
Score = 50.4 bits (115), Expect = 3e-05
Identities = 29/118 (24%), Positives = 53/118 (44%), Gaps = 1/118 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNHGD-HIVSSDDVYGGTN 442
YG G T LE+ + L+GG F + D H + +D +YG
Sbjct: 55 YGARGTTTNFELEKLICTLEGGYRAQLFPTGLAALAMVLLNYASKDVHFLITDAIYGPVR 114
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+ + ++G+ F + V+ ++ NTK+I E+P + L +++D+ + KIA
Sbjct: 115 TICELFLDKMGVEIDFLK-ADASDVEEKIKPNTKLILCESPGSILYEIIDLPKLCKIA 171
>UniRef50_Q62BJ4 Cluster: Trans-sulfuration enzyme family protein;
n=15; Burkholderia|Rep: Trans-sulfuration enzyme family
protein - Burkholderia mallei (Pseudomonas mallei)
Length = 433
Score = 49.6 bits (113), Expect = 6e-05
Identities = 33/133 (24%), Positives = 55/133 (41%), Gaps = 8/133 (6%)
Frame = +2
Query: 230 KQPAP-AEHTGFEYGRSGNPTRNTLEECLAALDGGKYGL-TFASXXXXXXXXXXXXNHGD 403
++P P E G Y R +P +E+ LA LDG + + T + GD
Sbjct: 64 RKPLPQGEAAGLVYSRFNHPNLEIVEDRLALLDGSEAAVVTSSGMSAISAIFLAFLRPGD 123
Query: 404 HIVSSDDVYGGTNRLLRQVIARLGINTTFTD------FTNIEKVKNAMQENTKMIWIETP 565
+V S +YGGT L+ + G+ D A Q ++ ++ETP
Sbjct: 124 QLVQSVPLYGGTETLIAKYFREWGVGAHSIDNGLSPQAIGAALEAAAQQGPVRLCYVETP 183
Query: 566 TNPLLKVVDIEAI 604
NP ++D++ +
Sbjct: 184 ANPTNALIDLDGM 196
>UniRef50_A1CUZ3 Cluster: Homocysteine synthase, putative; n=1;
Neosartorya fischeri NRRL 181|Rep: Homocysteine
synthase, putative - Neosartorya fischeri (strain ATCC
1020 / DSM 3700 / NRRL 181)(Aspergillus fischerianus
(strain ATCC 1020 / DSM 3700 / NRRL 181))
Length = 429
Score = 49.6 bits (113), Expect = 6e-05
Identities = 28/102 (27%), Positives = 45/102 (44%)
Frame = +2
Query: 308 CLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTT 487
C+ + G T + GD+IV+S V+GGT + + +LGI
Sbjct: 86 CMPTVRGVAACATASGTAAVSMTLMALAGVGDNIVASSTVHGGTYHQFKVLAPQLGIECR 145
Query: 488 FTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKI 613
F E + ++ TK I++E+ +NP V D EA+ I
Sbjct: 146 FVASNEPEDFRALLEGKTKFIFVESISNPKYTVPDFEALADI 187
>UniRef50_Q01X62 Cluster: Cystathionine gamma-synthase; n=1;
Solibacter usitatus Ellin6076|Rep: Cystathionine
gamma-synthase - Solibacter usitatus (strain Ellin6076)
Length = 415
Score = 49.2 bits (112), Expect = 8e-05
Identities = 32/121 (26%), Positives = 53/121 (43%), Gaps = 4/121 (3%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGK-YGLTFASXXXXXXXXXXXXNHGDH-IVSSDDVYGGT 439
Y R +P LE+ + L+ G Y F S D +V + +YGGT
Sbjct: 72 YSRFSHPNAEILEDQIVPLEAGAAYSAVFNSGMAAIQTAFFAYARPDSTMVYTTPLYGGT 131
Query: 440 NRLLRQVIARLGINTTFTDFTNIEKVKNAMQ--ENTKMIWIETPTNPLLKVVDIEAIVKI 613
L+ + + LG+ E ++ A++ N M+++ETP NP + + DIE +
Sbjct: 132 TGLIHKFMKPLGVTGIPVTSGKTEAIEEAIRGARNCCMVYLETPANPTMIMTDIERAAEA 191
Query: 614 A 616
A
Sbjct: 192 A 192
>UniRef50_A2Y9X5 Cluster: Putative uncharacterized protein; n=1;
Oryza sativa (indica cultivar-group)|Rep: Putative
uncharacterized protein - Oryza sativa subsp. indica
(Rice)
Length = 408
Score = 49.2 bits (112), Expect = 8e-05
Identities = 25/76 (32%), Positives = 41/76 (53%)
Frame = +2
Query: 128 QKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEE 307
++P ATI + + S + TP+ + TFKQP+ ++ ++Y RSGNPTR+ L+
Sbjct: 94 KEPSVATILTSFENSFDGFGSMS--TPLYQTATFKQPSATDNGPYDYTRSGNPTRDVLQS 151
Query: 308 CLAALDGGKYGLTFAS 355
+A L+ F S
Sbjct: 152 LMAKLEKADQAFCFTS 167
Score = 46.4 bits (105), Expect = 6e-04
Identities = 19/41 (46%), Positives = 30/41 (73%)
Frame = +2
Query: 494 DFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
D T I +V +A+ TK++W+E+PTNP L++ DI+ I +IA
Sbjct: 177 DTTKISEVTSAIGPLTKLVWLESPTNPRLQITDIKKIAEIA 217
>UniRef50_Q5NQQ3 Cluster: Cystathionine beta-lyase; n=41;
Proteobacteria|Rep: Cystathionine beta-lyase - Zymomonas
mobilis
Length = 682
Score = 48.4 bits (110), Expect = 1e-04
Identities = 36/150 (24%), Positives = 60/150 (40%), Gaps = 2/150 (1%)
Frame = +2
Query: 173 PEKWNSAAVVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALD-GGKYGLTF 349
P W ++ ++ V P + YGR G PT+ L E L L G + + +
Sbjct: 311 PPVWRASTILFDSVEDLREASSHPDDQ--LYYGRRGTPTQWALSEALTELHPGAEATMLY 368
Query: 350 ASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNA 526
S GD ++ D Y T V+ GIN T+ D + ++
Sbjct: 369 PSGVAALSMALLSALEAGDELLMVDSCYEPTRVFCDTVLKAQGINVTYYDPLIGQDIEQL 428
Query: 527 MQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
T+ I++E+P + +V DI I ++A
Sbjct: 429 FTPQTRAIFMESPGSLTFEVQDIPGICEVA 458
>UniRef50_Q0C2A8 Cluster: Cystathionine beta-lyase; n=1; Hyphomonas
neptunium ATCC 15444|Rep: Cystathionine beta-lyase -
Hyphomonas neptunium (strain ATCC 15444)
Length = 389
Score = 48.4 bits (110), Expect = 1e-04
Identities = 33/151 (21%), Positives = 62/151 (41%), Gaps = 3/151 (1%)
Frame = +2
Query: 176 EKWNSAAVVTPIVTSTT--FKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYG-LT 346
E+ V P+ ++T F+ A YGR G LE + L+G K+ L
Sbjct: 19 ERLGRVTVNPPVERASTVLFRTEAQLYGPKPTYGRMGLTVHRELEAAMCILEGAKHTRLA 78
Query: 347 FASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNA 526
G H + +D YG T R + + +G+ D ++
Sbjct: 79 SNGLQACALAIASVVEAGGHFLFTDSAYGPTARFCEKRLKAMGVEAERFDPRMGAGIERL 138
Query: 527 MQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
++NT+ I +E+P + ++ D+ A+ ++A+
Sbjct: 139 FRDNTQAILVESPGSLTFEISDLPAMAQVAK 169
>UniRef50_A6W2A4 Cluster: Cystathionine beta-lyase; n=1; Marinomonas
sp. MWYL1|Rep: Cystathionine beta-lyase - Marinomonas
sp. MWYL1
Length = 388
Score = 48.4 bits (110), Expect = 1e-04
Identities = 27/118 (22%), Positives = 52/118 (44%), Gaps = 1/118 (0%)
Frame = +2
Query: 266 YGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSSDDVYGGTN 442
YGR G T + L + L+GG F + GDH++ D ++ T
Sbjct: 57 YGRRGTTTAHELAAAINDLEGGDGCFLFPTGIAAIAGAISAYVGAGDHLLVVDTIFSATR 116
Query: 443 RLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIA 616
+ + R G+ + + N + ++ NTK++ IE+P + +V+D+ + + A
Sbjct: 117 TYCEKQLTRNGVEIEYFPW-NTTDISPYLKSNTKVVMIESPASQTYEVMDLPKLCESA 173
>UniRef50_A5W0L6 Cluster: Cys/Met metabolism
pyridoxal-phosphate-dependent enzyme; n=3; Pseudomonas
putida|Rep: Cys/Met metabolism
pyridoxal-phosphate-dependent enzyme - Pseudomonas
putida F1
Length = 397
Score = 48.4 bits (110), Expect = 1e-04
Identities = 32/120 (26%), Positives = 53/120 (44%), Gaps = 1/120 (0%)
Frame = +2
Query: 254 TGFEYGRSGNPTRNTLEECLAALDGGKYG-LTFASXXXXXXXXXXXXNHGDHIVSSDDVY 430
+G YG PT L + +A L+ GK+ LT + GDH+++ D +
Sbjct: 64 SGLYYGGVDTPTTRQLSQRVADLEKGKFAVLTPSGQSAFNLLLTTFVKPGDHVLAGDTIV 123
Query: 431 GGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVK 610
T LL +G+ + + +KN + TK+I E P +V++I AIV+
Sbjct: 124 YSTRWLLNH-FENIGVKIEYFTPSEAATLKNKLTLKTKLIIFENPGAFTYEVMNINAIVE 182
>UniRef50_Q98KA4 Cluster: Probable cystathionine/methionine
gamma-synthase/lyase; n=3; Alphaproteobacteria|Rep:
Probable cystathionine/methionine gamma-synthase/lyase -
Rhizobium loti (Mesorhizobium loti)
Length = 371
Score = 47.6 bits (108), Expect = 2e-04
Identities = 35/143 (24%), Positives = 57/143 (39%), Gaps = 1/143 (0%)
Frame = +2
Query: 185 NSAAVVTPIVTSTTFKQPAPAEHTGFE-YGRSGNPTRNTLEECLAALDGGKYGLTFASXX 361
N + P+ ++ F P TG + YGR NPT +E L L+ + +
Sbjct: 22 NGDPIPLPLTMASIFH--TPGVETGVDQYGRYDNPTWRAVEHVLGHLEDAQCVSFPSGMG 79
Query: 362 XXXXXXXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENT 541
GD ++ D Y T + + + LGI D + +
Sbjct: 80 AISSVFFALLKSGDRVLLPADGYHATRAMAERFLKPLGITC---DTRPTPTFLDGGFKGY 136
Query: 542 KMIWIETPTNPLLKVVDIEAIVK 610
++++ETP+NP L + DI AI K
Sbjct: 137 SLVFVETPSNPRLDICDISAIAK 159
>UniRef50_A4QZ48 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 712
Score = 47.6 bits (108), Expect = 2e-04
Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 1/88 (1%)
Frame = +2
Query: 284 PTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXX-XNHGDHIVSSDDVYGGTNRLLRQV 460
PT + E+ +AAL+ G + AS GD ++ S +GGT + +
Sbjct: 503 PTNDAFEKRMAALEDGNNAASLASGAATALKVAMSLAGAGDSVIVSTFAHGGTFHQFKII 562
Query: 461 IARLGINTTFTDFTNIEKVKNAMQENTK 544
R+GI T F D ++ KV++ + + TK
Sbjct: 563 PQRMGIETRFCDSNDLPKVRSLVDQRTK 590
>UniRef50_Q5LN68 Cluster: Cys/Met metabolism PLP-dependent enzyme
family protein; n=2; Rhodobacterales|Rep: Cys/Met
metabolism PLP-dependent enzyme family protein -
Silicibacter pomeroyi
Length = 371
Score = 47.2 bits (107), Expect = 3e-04
Identities = 33/141 (23%), Positives = 58/141 (41%)
Frame = +2
Query: 197 VVTPIVTSTTFKQPAPAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXX 376
V P+V S+ + P + + YGR+ NPT LE L L+G + +
Sbjct: 28 VALPLVQSSMYHLPGTPDGSN-SYGRADNPTWVALEHALEHLEGASCRVFPSGMGAISAA 86
Query: 377 XXXXXNHGDHIVSSDDVYGGTNRLLRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWI 556
G ++ D Y T L + + LG+N + ++++
Sbjct: 87 LFATLQAGQRLLIPADGYYVTRLLADRYLRPLGVNVEERPTAGFAEGGFG---GFDVVFL 143
Query: 557 ETPTNPLLKVVDIEAIVKIAR 619
ETP+NP L ++D+ A+ + R
Sbjct: 144 ETPSNPGLDLIDLAAVARAVR 164
>UniRef50_Q8G801 Cluster: Putative uncharacterized protein; n=2;
Bifidobacterium longum|Rep: Putative uncharacterized
protein - Bifidobacterium longum
Length = 89
Score = 46.0 bits (104), Expect = 7e-04
Identities = 32/72 (44%), Positives = 36/72 (50%), Gaps = 8/72 (11%)
Frame = +2
Query: 140 FATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQP--------APAEHTGFEYGRSGNPTRN 295
F T AIHAG EP N A V PI S F A + GFEY R NPT +
Sbjct: 5 FRTQAIHAGYEPLD-NGRAAVPPIYASAAFDLGDAARGDALAGGDIDGFEYSRVANPTVD 63
Query: 296 TLEECLAALDGG 331
LE+ LAAL+ G
Sbjct: 64 ALEKRLAALEDG 75
>UniRef50_Q26GX1 Cluster: Cys/Met metabolism PLP-dependent enzyme;
n=2; Flavobacteria|Rep: Cys/Met metabolism PLP-dependent
enzyme - Flavobacteria bacterium BBFL7
Length = 423
Score = 44.4 bits (100), Expect = 0.002
Identities = 36/132 (27%), Positives = 53/132 (40%), Gaps = 7/132 (5%)
Frame = +2
Query: 242 PAEHTGFEYGRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXX-NHGDHIVSS 418
P E G Y R NP LE L D F S G ++ S
Sbjct: 58 PGEEMGLIYSRINNPDLEILENRLRLWDKADDCAVFESGMSAISTVLMEFLEPGQVLLYS 117
Query: 419 DDVYGGTNRLLRQVIARLGINTT-----FTDFTNIEKVKNA-MQENTKMIWIETPTNPLL 580
YGGT+ + + + GI++ + I+ VK+A + ++ IETP NP
Sbjct: 118 SPTYGGTDHFINHFLPKYGIHSLGFKSGMSKEEIIKLVKDAGYADKIALMHIETPANPTN 177
Query: 581 KVVDIEAIVKIA 616
++DIE +IA
Sbjct: 178 ALIDIEMCREIA 189
>UniRef50_A4S3Y0 Cluster: Putative 2nd cystathione gamma synthase;
n=1; Ostreococcus lucimarinus CCE9901|Rep: Putative 2nd
cystathione gamma synthase - Ostreococcus lucimarinus
CCE9901
Length = 386
Score = 42.3 bits (95), Expect = 0.009
Identities = 45/177 (25%), Positives = 67/177 (37%), Gaps = 5/177 (2%)
Frame = +2
Query: 104 MADHGFLKQKPGFATIAIHAGQEPEKWNSAAVVTPIVTSTTFKQPAPAEHTGFE-----Y 268
M DHG L + A A +P + +V+ PI STT+ + E F Y
Sbjct: 1 MLDHGTLLVRG-----AADAADDPTR----SVIQPIYPSTTYARDDAHELPRFRDRTLCY 51
Query: 269 GRSGNPTRNTLEECLAALDGGKYGLTFASXXXXXXXXXXXXNHGDHIVSSDDVYGGTNRL 448
R NP+ E L L+ G F+S G SS +R
Sbjct: 52 ARPDNPSVRACERTLRDLERGSDCALFSSGMAAVNAVLEGAVRGTSDASSFAC--SPSRG 109
Query: 449 LRQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVKIAR 619
V AR+ +E + ++W+E+P NP V+D+E +V +AR
Sbjct: 110 YFAVRARIREWCAARGVEVVEYDPDVPGRKAALVWVESPANPTWDVMDLEQVVAVAR 166
>UniRef50_O58821 Cluster: Putative uncharacterized protein PH1094;
n=1; Pyrococcus horikoshii|Rep: Putative uncharacterized
protein PH1094 - Pyrococcus horikoshii
Length = 121
Score = 40.7 bits (91), Expect = 0.027
Identities = 37/104 (35%), Positives = 45/104 (43%), Gaps = 1/104 (0%)
Frame = -3
Query: 561 VSIQIILVFSCMAFFTFSIFVKSVNVVLIPNLAITCLNSLFVPPYTSSEDTM*SP*F-SR 385
VSI LV S ++ T S + + +L PNL L S V PY S E T SP +
Sbjct: 2 VSISTSLVLSFISS-TISSALGYASRILTPNLLPMSLASSIVVPYPSMERTASSPASRNE 60
Query: 384 ATKVVVAPRPEANVRPYFPPSNAAKHSSRVFLVGFPERPYSKPV 253
KV +A P R PS+ A SR VGF Y V
Sbjct: 61 KYKVAIAAIPLLKARALSAPSSLASLFSRFRTVGFSSLEYFNSV 104
>UniRef50_Q1VY21 Cluster: Coproporphyrinogen III oxidase; n=1;
Psychroflexus torquis ATCC 700755|Rep:
Coproporphyrinogen III oxidase - Psychroflexus torquis
ATCC 700755
Length = 58
Score = 40.3 bits (90), Expect = 0.036
Identities = 16/35 (45%), Positives = 22/35 (62%)
Frame = +2
Query: 506 IEKVKNAMQENTKMIWIETPTNPLLKVVDIEAIVK 610
+E + NTK+IW E PTNP++ V DI+A K
Sbjct: 1 METIDYYKTNNTKLIWAEIPTNPIMNVTDIKAFAK 35
>UniRef50_Q58097 Cluster: Probable aspartate aminotransferase 2;
n=1; Methanocaldococcus jannaschii|Rep: Probable
aspartate aminotransferase 2 - Methanococcus jannaschii
Length = 370
Score = 40.3 bits (90), Expect = 0.036
Identities = 20/49 (40%), Positives = 30/49 (61%)
Frame = +2
Query: 452 RQVIARLGINTTFTDFTNIEKVKNAMQENTKMIWIETPTNPLLKVVDIE 598
+ I LG F DFT +E ++ A+ + TK I I +P+NPL +V+D E
Sbjct: 127 KNFIRFLGAKPVFCDFT-VESLEEALSDKTKAIIINSPSNPLGEVIDRE 174
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 638,146,046
Number of Sequences: 1657284
Number of extensions: 13429108
Number of successful extensions: 40461
Number of sequences better than 10.0: 276
Number of HSP's better than 10.0 without gapping: 38657
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 40178
length of database: 575,637,011
effective HSP length: 97
effective length of database: 414,880,463
effective search space used: 45221970467
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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