Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fner10n24f
(506 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase... 176 3e-43
UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate ... 172 3e-42
UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome s... 166 3e-40
UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate dehydr... 161 1e-38
UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative g... 153 3e-36
UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunction... 151 1e-35
UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes: Me... 135 5e-31
UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes: ... 135 6e-31
UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes: Me... 130 2e-29
UniRef50_P56467 Cluster: Bifunctional protein folD [Includes: Me... 130 2e-29
UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes: Me... 127 1e-28
UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes: Me... 125 5e-28
UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes: Me... 122 4e-27
UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes: Me... 122 4e-27
UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes: ... 120 1e-26
UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes: Me... 120 2e-26
UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes: Me... 118 8e-26
UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate... 117 1e-25
UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes: Me... 116 4e-25
UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes: Me... 116 4e-25
UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes: Me... 115 7e-25
UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|R... 114 9e-25
UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep: P... 113 2e-24
UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes: Me... 113 3e-24
UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes: Me... 111 7e-24
UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase... 111 9e-24
UniRef50_O83714 Cluster: Bifunctional protein folD [Includes: Me... 111 9e-24
UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes: Me... 111 9e-24
UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes: Me... 111 9e-24
UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes: ... 110 2e-23
UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate dehydrog... 109 4e-23
UniRef50_UPI000038C811 Cluster: COG0190: 5,10-methylene-tetrahyd... 108 6e-23
UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes: Me... 108 6e-23
UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes: Me... 108 8e-23
UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes: Me... 107 2e-22
UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes: Me... 107 2e-22
UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes: Me... 107 2e-22
UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase... 105 4e-22
UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes: Me... 105 6e-22
UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes: Me... 105 6e-22
UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes: Me... 104 1e-21
UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes: Me... 103 2e-21
UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes: ... 102 4e-21
UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes: Me... 100 2e-20
UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes: Me... 100 2e-20
UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillu... 99 3e-20
UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes: Me... 99 3e-20
UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycopla... 99 5e-20
UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes: Me... 99 5e-20
UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase... 96 4e-19
UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes: Me... 95 6e-19
UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to ENSANGP000... 95 1e-18
UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolas... 95 1e-18
UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes: Me... 94 2e-18
UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes: Me... 93 2e-18
UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplas... 93 2e-18
UniRef50_O84081 Cluster: Bifunctional protein folD [Includes: Me... 93 3e-18
UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes: ... 93 4e-18
UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes: Me... 92 8e-18
UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of s... 91 2e-17
UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes: Me... 91 2e-17
UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes: ... 89 7e-17
UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes: Me... 86 4e-16
UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase... 86 5e-16
UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147, w... 85 1e-15
UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes: ... 83 4e-15
UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes: ... 83 5e-15
UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes: Me... 82 6e-15
UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate dehydr... 81 2e-14
UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes: ... 80 3e-14
UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes: Me... 79 4e-14
UniRef50_Q4DH06 Cluster: Methylenetetrahydrofolate dehydrogenase... 79 6e-14
UniRef50_O51057 Cluster: Bifunctional protein folD [Includes: Me... 79 8e-14
UniRef50_Q21285 Cluster: Dauer or aging adult overexpression pro... 78 1e-13
UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes: Me... 78 1e-13
UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis thal... 76 5e-13
UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate dehydrogenase... 75 7e-13
UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes: Me... 75 7e-13
UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whol... 75 9e-13
UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes: ... 75 9e-13
UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1; ... 73 3e-12
UniRef50_Q6L046 Cluster: Bifunctional protein folD [Includes: Me... 73 4e-12
UniRef50_UPI00006CB712 Cluster: tetrahydrofolate dehydrogenase/c... 71 2e-11
UniRef50_UPI0000D9D4E1 Cluster: PREDICTED: similar to Bifunction... 70 3e-11
UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes: Me... 70 3e-11
UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, wh... 69 5e-11
UniRef50_A6LP88 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 69 6e-11
UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1; Schis... 67 2e-10
UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes: Me... 66 4e-10
UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes: Me... 66 6e-10
UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121... 65 8e-10
UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3; ... 64 2e-09
UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes: Me... 63 3e-09
UniRef50_UPI00015563B5 Cluster: PREDICTED: similar to Mthfd2-pro... 63 4e-09
UniRef50_P47259 Cluster: Bifunctional protein folD [Includes: Me... 62 7e-09
UniRef50_A4M873 Cluster: Tetrahydrofolate dehydrogenase/cyclohyd... 61 2e-08
UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate for... 60 4e-08
UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes: Me... 56 5e-07
UniRef50_Q7NAE4 Cluster: Bifunctional protein folD [Includes: Me... 53 4e-06
UniRef50_UPI000023D48A Cluster: hypothetical protein FG10624.1; ... 52 7e-06
UniRef50_UPI0000D9A063 Cluster: PREDICTED: similar to Bifunction... 50 3e-05
UniRef50_Q6X5D4 Cluster: Methylene-THF dehydrogenase; n=1; Trepo... 50 4e-05
UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes: Me... 48 9e-05
UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome s... 47 2e-04
UniRef50_Q02046 Cluster: Methylenetetrahydrofolate dehydrogenase... 44 0.002
UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase... 42 0.011
UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase... 41 0.019
UniRef50_Q8ZSG1 Cluster: Alr7549 protein; n=3; Nostocaceae|Rep: ... 39 0.075
UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergil... 38 0.099
UniRef50_P11864 Cluster: Uncharacterized protein yhaC; n=7; Ente... 38 0.13
UniRef50_Q8YY73 Cluster: Sensor protein; n=2; Nostocaceae|Rep: S... 36 0.53
UniRef50_Q5KEZ0 Cluster: Methylenetetrahydrofolate dehydrogenase... 35 1.2
UniRef50_UPI000051DDF1 Cluster: ACETYLCHOLINE-BINDING PROTEIN; n... 34 1.6
UniRef50_A7MSZ8 Cluster: Putative uncharacterized protein; n=1; ... 34 1.6
UniRef50_Q18E84 Cluster: ATP-dependent DNA helicase; n=1; Haloqu... 34 1.6
UniRef50_Q9TW65 Cluster: Dystrophin-1; n=4; root|Rep: Dystrophin... 34 1.6
UniRef50_UPI0000E46F89 Cluster: PREDICTED: similar to nuclear tr... 33 2.8
UniRef50_A5MC89 Cluster: Putative uncharacterized protein; n=1; ... 33 2.8
UniRef50_Q22ST4 Cluster: Von Willebrand factor type A domain con... 33 2.8
UniRef50_O74539 Cluster: Peroxide stress-activated histidine kin... 33 2.8
UniRef50_Q60295 Cluster: Putative type-1 restriction enzyme MjaX... 33 4.9
UniRef50_P15028 Cluster: Iron(III) dicitrate-binding periplasmic... 33 4.9
UniRef50_A4G5B5 Cluster: Putative uncharacterized protein; n=1; ... 32 6.5
UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate dehydrogenase... 32 6.5
UniRef50_A6QZK7 Cluster: Putative uncharacterized protein; n=1; ... 32 6.5
>UniRef50_Q16F77 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=4; cellular organisms|Rep: Methylenetetrahydrofolate
dehydrogenase - Aedes aegypti (Yellowfever mosquito)
Length = 337
Score = 176 bits (428), Expect = 3e-43
Identities = 80/146 (54%), Positives = 115/146 (78%), Gaps = 1/146 (0%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLG-NRAPTIRCIIVGDDPASHTYVRNKVEAAKF 244
MA+++DGK +A +I+ EL+++I +W+ G NRAP + I++G+DPAS+TYV NK++AA
Sbjct: 32 MAKLIDGKQIAADIRMELREQIEEWMKQGGNRAPHLTAILIGEDPASNTYVSNKMKAAAD 91
Query: 245 VGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDI 424
VGI + T +DITEEQLL I+ LN+D+SVDGILVQLPVP INER+VC++++ +KD+
Sbjct: 92 VGITSKTERYSADITEEQLLKRIEELNQDDSVDGILVQLPVPGHINERKVCNSVSCDKDV 151
Query: 425 DGFHIINIGRLCVDLPTIVPATALAV 502
DGF+ NIGRLC+D+ T++P T L V
Sbjct: 152 DGFNERNIGRLCLDMNTLIPCTPLGV 177
>UniRef50_P13995 Cluster: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)]; n=66; cellular
organisms|Rep: Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor
[Includes: NAD-dependent methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Homo sapiens (Human)
Length = 350
Score = 172 bits (419), Expect = 3e-42
Identities = 72/144 (50%), Positives = 115/144 (79%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A ++ G+ LA +IK+E++Q++ +WV+ GN+ P + I+VG++PASH+YV NK AA VG
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
I++ TI + + I+EE+LL+ I LN D++VDG+LVQLP+P+ I+ERR+C+A++P+KD+DG
Sbjct: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156
Query: 431 FHIINIGRLCVDLPTIVPATALAV 502
FH+IN+GR+C+D +++PAT V
Sbjct: 157 FHVINVGRMCLDQYSMLPATPWGV 180
>UniRef50_Q4RT28 Cluster: Chromosome 12 SCAF14999, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 12 SCAF14999, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 342
Score = 166 bits (403), Expect = 3e-40
Identities = 71/144 (49%), Positives = 107/144 (74%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A ++ G+ LA +I++E + + +WV G+R P + ++VGDDPASH+YV NK AA +G
Sbjct: 30 AVVISGRKLARQIREEARADVEKWVLTGHRRPHLSVVLVGDDPASHSYVLNKTRAAADIG 89
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
I + TI + SDI+EE+LL I LN D+ VDG+LVQLP+P+ I+ER +C+A+AP KD+DG
Sbjct: 90 ISSETILKHSDISEEELLDLIDKLNTDHRVDGLLVQLPLPEHIDERTICNAVAPTKDVDG 149
Query: 431 FHIINIGRLCVDLPTIVPATALAV 502
FH++N+GR+C+D +++PAT V
Sbjct: 150 FHVVNVGRMCLDQSSMLPATPWGV 173
>UniRef50_UPI000065DF90 Cluster: methylenetetrahydrofolate
dehydrogenase (NADP+ dependent) 2-like; n=1; Takifugu
rubripes|Rep: methylenetetrahydrofolate dehydrogenase
(NADP+ dependent) 2-like - Takifugu rubripes
Length = 400
Score = 161 bits (390), Expect = 1e-38
Identities = 72/144 (50%), Positives = 106/144 (73%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A ++ G LA +I++E+++ + + V+ GN P + ++VG+DPAS TYV+NK AA +G
Sbjct: 7 AVVISGTELARQIQREIQRDVEELVAQGNMRPHLGVVLVGEDPASRTYVKNKTRAASILG 66
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
I + T+ R S +++E+LL I +N D V G+LVQLP+P+ INER VC+AIAPEKD+DG
Sbjct: 67 ISSDTVVRPSSVSQEELLELIDKMNRDWRVSGLLVQLPLPEHINERAVCNAIAPEKDVDG 126
Query: 431 FHIINIGRLCVDLPTIVPATALAV 502
FHI+NIG+LC+D ++VPAT AV
Sbjct: 127 FHIVNIGKLCLDQRSMVPATPAAV 150
>UniRef50_UPI00015B49ED Cluster: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to putative
glyoxylate reductase/hydroxypyruvate reductase - Nasonia
vitripennis
Length = 699
Score = 153 bits (370), Expect = 3e-36
Identities = 70/144 (48%), Positives = 103/144 (71%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A I+DG +A ++ +E+K ++ + G + P + I+VG++PAS YV KV+AAK VG
Sbjct: 28 AAIIDGNGVADQVLEEVKAEVDEMTRNGEKRPKLIAILVGNNPASKAYVGRKVKAAKTVG 87
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
I++ T+ + IT+E+LL E+Q LN+D +VDG+LVQLPVP+ I+ER VC A+ P KD+DG
Sbjct: 88 IESETLRFEDSITQEELLHEVQKLNDDPTVDGLLVQLPVPEHISEREVCQAVTPTKDVDG 147
Query: 431 FHIINIGRLCVDLPTIVPATALAV 502
FH+ NIG L ++ I+PATAL V
Sbjct: 148 FHLSNIGNLALNNKGIIPATALGV 171
>UniRef50_UPI0000DB7ABF Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Apis mellifera
Length = 407
Score = 151 bits (365), Expect = 1e-35
Identities = 71/156 (45%), Positives = 106/156 (67%)
Frame = +2
Query: 35 TYIDSLGSASIMARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTY 214
TY + S+ A I+DGK +A +I+ ELK + W++ + P + I VG++PAS Y
Sbjct: 98 TYCRNSNSSRQNAIIIDGKKIANKIQNELKITVDNWINDNKKRPKLVAIKVGNNPASKIY 157
Query: 215 VRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRV 394
V K++AA F+GI+ TI+ D +++ +++EI NLN+D +VDGILVQLP+ +NE+ V
Sbjct: 158 VEKKIKAANFIGIENYTIHLDEKSSQQDIINEIDNLNKDKTVDGILVQLPLIKHMNEQEV 217
Query: 395 CDAIAPEKDIDGFHIINIGRLCVDLPTIVPATALAV 502
C AI P KD+DGFH+ N+G L ++ I+PATALAV
Sbjct: 218 CQAIIPSKDVDGFHLENLGNLALNRNGIIPATALAV 253
>UniRef50_Q7MVE9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=52; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 296
Score = 135 bits (327), Expect = 5e-31
Identities = 61/144 (42%), Positives = 97/144 (67%)
Frame = +2
Query: 74 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 253
++LDGK ++ EIK+E+ + + + G R P + ++VG D S TY+ +KV+A + VG
Sbjct: 6 KLLDGKKISGEIKQEIAAVVNELLEKGGRRPHLAGVLVGHDGGSETYMASKVKACEEVGF 65
Query: 254 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 433
+ I + D+TEE+LL+ + LN+D +VDG +VQLP+P I+E+++ +A+ P KD+DGF
Sbjct: 66 TSSLIRYEDDVTEEELLACVHRLNQDPTVDGFIVQLPLPKHIDEQKIIEAVDPRKDVDGF 125
Query: 434 HIINIGRLCVDLPTIVPATALAVV 505
H IN+GRL + LP V AT +V
Sbjct: 126 HPINVGRLSIGLPGFVSATPKGIV 149
>UniRef50_Q6F9E6 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Proteobacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acinetobacter sp. (strain ADP1)
Length = 297
Score = 135 bits (326), Expect = 6e-31
Identities = 63/139 (45%), Positives = 94/139 (67%)
Frame = +2
Query: 74 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 253
+I+DGKA+A + +E+K ++ ++ + G P + ++VG+DPAS YVRNKV+ A FVGI
Sbjct: 12 KIIDGKAIAQSVLEEVKLEVERYKAQGIE-PCLAVVLVGEDPASQVYVRNKVQKAAFVGI 70
Query: 254 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 433
+L D+D++E++LL++I LN + V GILVQLP+P INE RV + I P+KD+DGF
Sbjct: 71 RSLEFRFDADLSEDELLTQIDRLNTERGVHGILVQLPLPKQINETRVLERIHPQKDVDGF 130
Query: 434 HIINIGRLCVDLPTIVPAT 490
H N+G L + P T
Sbjct: 131 HSENVGGLSQGRDVLTPCT 149
>UniRef50_Q6D2E6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Erwinia carotovora subsp. atroseptica (Pectobacterium
atrosepticum)
Length = 287
Score = 130 bits (314), Expect = 2e-29
Identities = 59/145 (40%), Positives = 94/145 (64%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A+I+DGK +A ++K E+ ++ Q ++ G RAP + ++VGD+PAS YV +K + + VG
Sbjct: 3 AKIIDGKTIAQQVKDEVAARVTQRLAEGKRAPGLAVVLVGDNPASQIYVTSKRKVCEEVG 62
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
+ + + TE +LL+ I LN D ++DGILVQLP+P+ I+ +V + IAP+KD+DG
Sbjct: 63 FISRSYDLPITTTESELLALIDQLNADQAIDGILVQLPLPEGIDNTKVIERIAPDKDVDG 122
Query: 431 FHIINIGRLCVDLPTIVPATALAVV 505
FH N+GRLC P + T ++
Sbjct: 123 FHPYNVGRLCQRAPLLRACTPRGII 147
>UniRef50_P56467 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Helicobacter pylori (Campylobacter pylori)
Length = 290
Score = 130 bits (313), Expect = 2e-29
Identities = 63/143 (44%), Positives = 95/143 (66%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
+LDG+ALA I+K+LK KI + ++ P + I+VG DPAS TYV K++A + VG+D
Sbjct: 8 LLDGQALADNIEKDLKHKIQIITAQTHKRPKLAVILVGKDPASITYVNMKIKACERVGMD 67
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 436
+ITE +LLS I++ N D ++ G+LVQLP+P I+ + + +AI P KD+DGFH
Sbjct: 68 FDLKTLQENITEAKLLSLIKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFH 127
Query: 437 IINIGRLCVDLPTIVPATALAVV 505
+NIG+LC + +PAT + V+
Sbjct: 128 PLNIGKLCTQKESFLPATPMGVM 150
>UniRef50_Q6F1V0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Mollicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mesoplasma florum (Acholeplasma florum)
Length = 286
Score = 127 bits (307), Expect = 1e-28
Identities = 62/143 (43%), Positives = 90/143 (62%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
ILDGK +A K+EL KI+++ + G R P + I+VG+DPAS YV +K++ A VGI
Sbjct: 3 ILDGKKVASRRKEELTAKISKYHNKGLRKPKLVVIMVGNDPASEVYVSHKIKVANEVGIY 62
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 436
+ + D DI +E+L ++I LN D ++DGIL+QLP+P E AI P KD+DGFH
Sbjct: 63 SELLRFDKDIKKEELYNKINELNNDQNIDGILLQLPLPIDFIEEDYLQAITPSKDVDGFH 122
Query: 437 IINIGRLCVDLPTIVPATALAVV 505
IN G++ T+ P T L ++
Sbjct: 123 YINQGKMLQGYDTVYPCTPLGII 145
>UniRef50_Q8KN38 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Sphingobium chlorophenolicum|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Sphingobium
chlorophenolicum
Length = 316
Score = 125 bits (302), Expect = 5e-28
Identities = 61/143 (42%), Positives = 90/143 (62%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
MA I+ G A A + +L + +A++ + APT+ ++VGDDPASH YVR K+E + V
Sbjct: 1 MASIISGTAAAEGLLADLTRDVARFSQVHGYAPTLVAVLVGDDPASHIYVRKKIEQCRKV 60
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
G++++ +D +EE LL+ I +LN D V GILVQLP+P I+ +V D I P KD+D
Sbjct: 61 GMESVEHRLPADCSEEDLLALIASLNADERVHGILVQLPLPAQIDSGKVLDTIDPRKDVD 120
Query: 428 GFHIINIGRLCVDLPTIVPATAL 496
GFH +N+ RL +VP T +
Sbjct: 121 GFHPVNVFRLSTGTGGLVPCTPM 143
>UniRef50_Q9ZD32 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Rickettsia|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rickettsia prowazekii
Length = 286
Score = 122 bits (295), Expect = 4e-27
Identities = 60/141 (42%), Positives = 90/141 (63%), Gaps = 1/141 (0%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
I+DGKALA EI +LK +I + +P + ++VGD+PAS YV+NK++ A VGID
Sbjct: 5 IIDGKALANEILADLKLEIQGFKEKTKTSPKLAIVLVGDNPASMIYVKNKIKNAHQVGID 64
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 436
L +N ++I + L+ +I LN D + GI+VQLP+P +I+E ++ A+ P KD DGFH
Sbjct: 65 TLLVNLSTNIYTDDLILKINELNLDKGISGIIVQLPLPSSIDENKILSAVLPSKDSDGFH 124
Query: 437 IINIGRLCVDL-PTIVPATAL 496
+N+G L + +P TAL
Sbjct: 125 PLNVGYLHSGINQGFIPCTAL 145
>UniRef50_Q8EQ43 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=45; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Oceanobacillus iheyensis
Length = 285
Score = 122 bits (295), Expect = 4e-27
Identities = 58/146 (39%), Positives = 95/146 (65%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
MA +L+GK L+ E+K+++K ++ + G P + I+VGD+PAS +YV+ K +A
Sbjct: 1 MATLLNGKELSEELKQKMKIEVDELKEKG-LTPHLTVILVGDNPASKSYVKGKEKACAVT 59
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
GI + I +I++++LL I N D+SV GILVQLP+PD ++E+++ AI+P KD+D
Sbjct: 60 GISSNLIELPENISQDELLQIIDEQNNDDSVHGILVQLPLPDQMDEQKIIHAISPAKDVD 119
Query: 428 GFHIINIGRLCVDLPTIVPATALAVV 505
GFH IN+G++ T +P T ++
Sbjct: 120 GFHPINVGKMMTGEDTFIPCTPYGIL 145
>UniRef50_Q74GN1 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=13; Bacteria|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Geobacter sulfurreducens
Length = 290
Score = 120 bits (290), Expect = 1e-26
Identities = 56/142 (39%), Positives = 88/142 (61%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
+LDGK A + E+ +K+A + G R P + I+VG+ S +YV++K+ + G +
Sbjct: 3 LLDGKKCAESLVAEIARKVAGYTESGLRTPHMTIILVGEHAPSESYVKSKIATSGLAGFE 62
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 436
+ + I E +LL++I+ +NED + DG++VQLP+P IN++ V +AIAPEKDIDGFH
Sbjct: 63 STLLRFPETIRESELLAKIKEVNEDPTTDGLIVQLPLPKHINQQHVINAIAPEKDIDGFH 122
Query: 437 IINIGRLCVDLPTIVPATALAV 502
N GR+ + PATA +
Sbjct: 123 PANFGRMTLGQKAFRPATAYGI 144
>UniRef50_Q63SL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=226; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Burkholderia pseudomallei (Pseudomonas
pseudomallei)
Length = 285
Score = 120 bits (289), Expect = 2e-26
Identities = 59/145 (40%), Positives = 89/145 (61%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A ++DG AL+ ++ + ++ A + G+R P + I+VGD+PAS YVRNK++A + G
Sbjct: 3 ATLIDGNALSKTLRAQAAERAAALAARGHR-PGLAVILVGDNPASEVYVRNKIKACEDNG 61
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
+L + ++E +LL+ I LN D + GILVQLP+P I+ +V +AIAPEKD+DG
Sbjct: 62 FFSLKDRYPATLSEPELLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDG 121
Query: 431 FHIINIGRLCVDLPTIVPATALAVV 505
FH+ N G L P P T V+
Sbjct: 122 FHVANAGALLTGKPLFRPCTPYGVM 146
>UniRef50_Q1II76 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Acidobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Acidobacteria bacterium (strain Ellin345)
Length = 307
Score = 118 bits (284), Expect = 8e-26
Identities = 56/142 (39%), Positives = 90/142 (63%)
Frame = +2
Query: 65 IMARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKF 244
++A ILDG ++ EIK E+ ++A+ + G P + ++VG +PAS YVRNKV+A +
Sbjct: 1 MLATILDGNKISAEIKTEVAAEVAELKAKG-LTPGLAVVLVGHNPASEIYVRNKVKACEM 59
Query: 245 VGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDI 424
GI + ++ LL +++LN N +DGILVQLP+P ++ +++ A++PEKD+
Sbjct: 60 TGIYSEQHTPPDTVSTADLLQLVESLNRRNDIDGILVQLPLPKQVDSKKILLAVSPEKDV 119
Query: 425 DGFHIINIGRLCVDLPTIVPAT 490
DGFH +N+G L P +VP T
Sbjct: 120 DGFHPMNVGYLSTVRPGLVPCT 141
>UniRef50_Q5IWX9 Cluster: Plastid 5,10-methylene-tetrahydrofolate
dehydrogenase; n=1; Prototheca wickerhamii|Rep: Plastid
5,10-methylene-tetrahydrofolate dehydrogenase -
Prototheca wickerhamii
Length = 248
Score = 117 bits (282), Expect = 1e-25
Identities = 64/151 (42%), Positives = 96/151 (63%), Gaps = 3/151 (1%)
Frame = +2
Query: 47 SLGSASIM-ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRN 223
++ +AS M A ++DGK +A I+ ELK ++ + + N P + ++VG+ S TYVR+
Sbjct: 53 AVATASAMPAALIDGKKIAETIRGELKVEVDELRAQYNTVPGLAVVLVGERKDSQTYVRS 112
Query: 224 KVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDA 403
K +A VGI++ + TEE++L+ + N+D +V GILVQLP+P+ INE+RV DA
Sbjct: 113 KKKACDEVGINSFGADLPETATEEEVLAVVAKFNDDPNVHGILVQLPLPEHINEKRVLDA 172
Query: 404 IAPEKDIDGFHIINIGRLCV--DLPTIVPAT 490
I+ EKD+DGFH NIG L + PT V T
Sbjct: 173 ISLEKDVDGFHPNNIGELAMRGRSPTYVSCT 203
>UniRef50_Q9KQQ6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=44; Gammaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Vibrio cholerae
Length = 286
Score = 116 bits (278), Expect = 4e-25
Identities = 54/145 (37%), Positives = 89/145 (61%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A+ +DG ++ ++ E+ ++ V G RAP + ++VG+DPAS YV +K A + VG
Sbjct: 3 AQNIDGTLISQTVRSEVAARVKARVQAGLRAPGLAVVLVGEDPASQVYVGSKRRACEEVG 62
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
+ + + + +EE LLS ++ LN D +DGILVQLP+P ++ +V ++I PEKD+DG
Sbjct: 63 FVSKSFDLPATASEEALLSLVEELNNDPQIDGILVQLPLPAGMDTTKVLESIHPEKDVDG 122
Query: 431 FHIINIGRLCVDLPTIVPATALAVV 505
FH N+GRL +P + T ++
Sbjct: 123 FHPYNVGRLAQRIPKLRSCTPKGII 147
>UniRef50_Q4FNW1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelagibacter ubique
Length = 281
Score = 116 bits (278), Expect = 4e-25
Identities = 53/140 (37%), Positives = 90/140 (64%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
++DGK +A E++++L+Q++ + + N+ P + I++G+ S YVR K +AA VG+
Sbjct: 3 LIDGKKIAAELREQLRQEVVELKAKHNKIPGLTVILIGEMAPSQIYVRMKEKAANEVGLK 62
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 436
+ I + E+ +L +I+ LN+D S+ GILVQLP+P I++++V + I P KD+DGFH
Sbjct: 63 SEVIRYPEAVEEKTVLDKIEELNKDESISGILVQLPLPKHIDKQKVIETILPGKDVDGFH 122
Query: 437 IINIGRLCVDLPTIVPATAL 496
+N+G L + VP T L
Sbjct: 123 PMNVGNLSSGYESSVPCTPL 142
>UniRef50_Q8DMU0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=90; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus elongatus (Thermosynechococcus
elongatus)
Length = 306
Score = 115 bits (276), Expect = 7e-25
Identities = 60/145 (41%), Positives = 88/145 (60%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A LDGK+LA I+++L + + + R+P + + VG+DPAS YVR K +A VG
Sbjct: 6 ATCLDGKSLAQSIERQLADHVRTFQAQWGRSPGLAVLRVGNDPASAVYVRAKEQACSRVG 65
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
I + + + ITE LL++I LN+D VDGIL+QLP+P ++ R + AI P+KD+DG
Sbjct: 66 IQSFGAHLPATITEAALLAKITELNQDERVDGILLQLPLPPHLDPRPLLYAIHPDKDVDG 125
Query: 431 FHIINIGRLCVDLPTIVPATALAVV 505
H N+GRL D P + T V+
Sbjct: 126 LHPENLGRLVRDEPGLRSCTPAGVM 150
>UniRef50_O65271 Cluster: F6N23.26 protein; n=20; Viridiplantae|Rep:
F6N23.26 protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 360
Score = 114 bits (275), Expect = 9e-25
Identities = 58/142 (40%), Positives = 89/142 (62%), Gaps = 2/142 (1%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A ++DGKA+A +I+ E+ ++++ P + I+VGD S TYVRNK +A VG
Sbjct: 69 AIVIDGKAVAKKIRDEITIEVSRMKESIGVIPGLAVILVGDRKDSATYVRNKKKACDSVG 128
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
I + + D +EE++L + N+D SV GILVQLP+P ++E+ + +A++ EKD+DG
Sbjct: 129 IKSFEVRLAEDSSEEEVLKSVSGFNDDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVDG 188
Query: 431 FHIINIGRLCV--DLPTIVPAT 490
FH +NIGRL + P VP T
Sbjct: 189 FHPLNIGRLAMRGREPLFVPCT 210
>UniRef50_Q9XYB0 Cluster: PugilistDominant; n=2; Coelomata|Rep:
PugilistDominant - Drosophila melanogaster (Fruit fly)
Length = 268
Score = 113 bits (273), Expect = 2e-24
Identities = 61/144 (42%), Positives = 92/144 (63%), Gaps = 4/144 (2%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKI-AQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
A+I+ G A+A I++EL+ ++ A L + P +R + VG S+ Y+R K++AA +
Sbjct: 4 AKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEI 63
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVP-DT-INERRVCDAIAPEKD 421
GIDA + ITE +LL +I +LNED V GI+VQ+P+ DT I+ R+ DA++PEKD
Sbjct: 64 GIDAAHVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKD 123
Query: 422 IDGFHIINIGRLCV-DLPTIVPAT 490
+DG H +N GRL + DL +P T
Sbjct: 124 VDGLHTVNEGRLAIGDLGGFLPCT 147
>UniRef50_A1AL91 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=9; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pelobacter propionicus (strain DSM 2379)
Length = 283
Score = 113 bits (271), Expect = 3e-24
Identities = 58/146 (39%), Positives = 87/146 (59%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
MA I+DGKA+A +I+ E+ + + G P + ++VGDD AS YV K +A
Sbjct: 1 MAHIIDGKAIAAKIRSEIASGVRELQGKGV-TPGLAVVLVGDDQASRVYVSMKEKACNDA 59
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
GI ++ ++ +E +LL+ ++ LN D + GILVQLP+P I+ +V +AI+P KD+D
Sbjct: 60 GIFSVEHKLAAETSEAELLALVELLNNDPKIHGILVQLPLPSQIDTDKVLEAISPFKDVD 119
Query: 428 GFHIINIGRLCVDLPTIVPATALAVV 505
GFH N+GRL V P P T V+
Sbjct: 120 GFHPYNVGRLSVGKPVFQPCTPYGVM 145
>UniRef50_Q5PBL6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Alphaproteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Anaplasma marginale (strain St. Maries)
Length = 299
Score = 111 bits (268), Expect = 7e-24
Identities = 59/142 (41%), Positives = 86/142 (60%), Gaps = 1/142 (0%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
M I+DGK +A + L+ + + + P + +IVGDDPAS YV NK A+ +
Sbjct: 1 MREIIDGKLVARGLLDRLRVSVDRLKAEHGIVPHLVVVIVGDDPASKLYVGNKQRKAEEL 60
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
G+ + TI + D ++E+LL I LN D +V GILVQLP+P I++ V +AI+PEKD+D
Sbjct: 61 GLQSRTIALEHDTSQEELLRIIDELNRDAAVHGILVQLPLPRHIDKELVINAISPEKDVD 120
Query: 428 GFHIINIGRLCV-DLPTIVPAT 490
GFH N G+L L ++P T
Sbjct: 121 GFHNANAGKLATGQLDCMIPCT 142
>UniRef50_A7D6I9 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Halorubrum lacusprofundi ATCC 49239|Rep:
Methenyltetrahydrofolate cyclohydrolase - Halorubrum
lacusprofundi ATCC 49239
Length = 307
Score = 111 bits (267), Expect = 9e-24
Identities = 57/139 (41%), Positives = 83/139 (59%)
Frame = +2
Query: 74 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 253
RI+DG+A+A +++ ++ + G P + +++ DDPAS TYV K + VGI
Sbjct: 13 RIIDGEAVAADVRDDVAAHVETLEEEGV-TPGLATVLMSDDPASETYVSMKQRDCEEVGI 71
Query: 254 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 433
+++ + D+D E+L I +LNE V GILVQLPVPD +++RRV IAP KD+DGF
Sbjct: 72 ESVHVEIDADAPAEELYETIDDLNEREDVHGILVQLPVPDHVDKRRVLRQIAPVKDVDGF 131
Query: 434 HIINIGRLCVDLPTIVPAT 490
H N+GRL P T
Sbjct: 132 HPENVGRLVAGDARFKPCT 150
>UniRef50_O83714 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Treponema pallidum
Length = 315
Score = 111 bits (267), Expect = 9e-24
Identities = 59/145 (40%), Positives = 80/145 (55%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
AR++DGK A E L ++ + AP + ++VGDDPAS TYV K A
Sbjct: 3 ARLIDGKQAAHECTARLATRVQALRAAVGTAPFLAAVLVGDDPASCTYVAAKQRALARAH 62
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
+ T + + Q+L I LNED V GIL+QLP+P ++ RVC A+APEKD+DG
Sbjct: 63 LRGETHRLPAHASHAQVLELIARLNEDARVHGILIQLPLPAHLDAARVCRAVAPEKDVDG 122
Query: 431 FHIINIGRLCVDLPTIVPATALAVV 505
FH +N G L + P VP T +V
Sbjct: 123 FHPLNCGALFLAQPGFVPCTPAGIV 147
>UniRef50_Q3YRE3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Proteobacteria|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Ehrlichia canis (strain Jake)
Length = 300
Score = 111 bits (267), Expect = 9e-24
Identities = 57/129 (44%), Positives = 80/129 (62%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A I++GKA+A +I L I + P + ++VGDDPASH YVRNK A+ +G
Sbjct: 3 ANIINGKAIAEDITGTLATCINDLKLQYSLVPCLIVVLVGDDPASHLYVRNKQRKAEMLG 62
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
+ + TI S +E L+ +I LN D++V GILVQLPVP I++ + + I P KD+DG
Sbjct: 63 LRSETILLPSTTSESSLIDKIHELNNDDNVHGILVQLPVPKHIDKNLIINTIDPRKDVDG 122
Query: 431 FHIINIGRL 457
FH N+GRL
Sbjct: 123 FHNDNVGRL 131
>UniRef50_Q9A8Y0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=82; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Caulobacter crescentus (Caulobacter
vibrioides)
Length = 297
Score = 111 bits (267), Expect = 9e-24
Identities = 51/140 (36%), Positives = 84/140 (60%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A+++DGKA A +++ ++ +++A + P + ++VG+DPAS YVRNK E G
Sbjct: 4 AKLIDGKAFAADLRAKIAEEVAALKAEHGVTPGLAVVLVGEDPASQVYVRNKGEQTTAAG 63
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
+ + T T+++LL+ + LN D + G+LVQ PVP I++ V A++P+KD+DG
Sbjct: 64 MYSETHRLPETTTQDELLAVVAKLNADPKIHGVLVQFPVPPHISQMDVVAALSPDKDVDG 123
Query: 431 FHIINIGRLCVDLPTIVPAT 490
+ N GRL LP + P T
Sbjct: 124 LTVTNAGRLASGLPALAPCT 143
>UniRef50_Q24UZ7 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Peptococcaceae|Rep: Bifunctional protein folD 2
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Desulfitobacterium hafniense (strain Y51)
Length = 284
Score = 110 bits (264), Expect = 2e-23
Identities = 53/141 (37%), Positives = 89/141 (63%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
MA++LDGK ++ +K+E+K+++ +W G P + ++VGDDPAS Y ++K + + +
Sbjct: 1 MAQLLDGKEISKVLKEEIKEEVKRWKEQGVN-PKLAVVLVGDDPASVVYAKSKQKVSDSL 59
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
GID +D +EE +L+ I +LN + V GI+++LP+P I++ RV A+ P+KD+D
Sbjct: 60 GIDFELTVLPADSSEESILALIDSLNANPDVHGIMIELPLPKHISKERVMAAVRPDKDVD 119
Query: 428 GFHIINIGRLCVDLPTIVPAT 490
G H IN G + + PAT
Sbjct: 120 GVHPINRGYILSGEEGLFPAT 140
>UniRef50_Q9LHH7 Cluster: 5,10-methylenetetrahydrofolate
dehydrogenase/5,10- methenyltetrahydrofolate
cyclohydrolase; n=7; Eukaryota|Rep:
5,10-methylenetetrahydrofolate dehydrogenase/5,10-
methenyltetrahydrofolate cyclohydrolase - Arabidopsis
thaliana (Mouse-ear cress)
Length = 299
Score = 109 bits (262), Expect = 4e-23
Identities = 55/147 (37%), Positives = 86/147 (58%), Gaps = 2/147 (1%)
Frame = +2
Query: 56 SASIMARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEA 235
S+ A+I+DGKA+A I+ E+ +++ + P + +IVG S TYV K +A
Sbjct: 4 SSDHTAKIIDGKAIAHTIRSEIAEEVRGLSEKHGKVPGLAVVIVGSRKDSQTYVNTKRKA 63
Query: 236 AKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPE 415
VGI + + +++E L+S++ LN + V GILVQLP+P INE + AI+ +
Sbjct: 64 CAEVGIKSFDVGLPEEVSEADLISKVHELNSNPDVHGILVQLPLPKHINEEHILGAISID 123
Query: 416 KDIDGFHIINIGRLCVD--LPTIVPAT 490
KD+DGFH +NIG+L + P +P T
Sbjct: 124 KDVDGFHPLNIGKLAMKGREPLFLPCT 150
>UniRef50_UPI000038C811 Cluster: COG0190:
5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl
tetrahydrofolate cyclohydrolase; n=1; Nostoc punctiforme
PCC 73102|Rep: COG0190: 5,10-methylene-tetrahydrofolate
dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase -
Nostoc punctiforme PCC 73102
Length = 292
Score = 108 bits (260), Expect = 6e-23
Identities = 57/129 (44%), Positives = 81/129 (62%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A++LDGKA+A +I++EL I Q R P + ++VGD+PAS YVRNK +A VG
Sbjct: 6 AKLLDGKAIAAKIQQELSVAITQLQPEIGRPPGLAVLMVGDNPASAAYVRNKEKACAKVG 65
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
I + + ++ T +L I LN+D VDGILVQLP+PD ++ + I P+KD DG
Sbjct: 66 IASFGKHFPAETTFRELEKVIAALNDDERVDGILVQLPLPDHLDAVALLHQIDPDKDADG 125
Query: 431 FHIINIGRL 457
H +N+GRL
Sbjct: 126 LHPVNLGRL 134
>UniRef50_Q3AYX2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=36; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Synechococcus sp. (strain CC9902)
Length = 293
Score = 108 bits (260), Expect = 6e-23
Identities = 57/130 (43%), Positives = 79/130 (60%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
MA LDGKALA ++ L+ +I + R P + + VGDDPAS YV NK +A +
Sbjct: 1 MALRLDGKALAKAVESRLQAQIESNLPQAGRPPGLAVLRVGDDPASAVYVANKEKACARI 60
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
G+ + + S ++LS IQ LN D VDGIL+QLP+P+ ++E + AI PEKD D
Sbjct: 61 GVASYGAHLPSSTPFAEVLSTIQQLNADPRVDGILLQLPLPEGLDEGPLLMAIDPEKDAD 120
Query: 428 GFHIINIGRL 457
G H +N+GRL
Sbjct: 121 GLHTLNLGRL 130
>UniRef50_Q8TK95 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Methanosarcina acetivorans
Length = 290
Score = 108 bits (259), Expect = 8e-23
Identities = 59/155 (38%), Positives = 89/155 (57%), Gaps = 3/155 (1%)
Frame = +2
Query: 50 LGSASIMARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKV 229
+ S +RI+DGK LA ++++E++ + S P + I+VGDDPAS YVR K
Sbjct: 1 MSDESYESRIIDGKVLAQQVEEEVRSGVEDLESNRGIVPGLATILVGDDPASKMYVRLKH 60
Query: 230 EAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTIN---ERRVCD 400
A + VGI A D T+E+LL+ I +LN++ V IL+QLP+P + + +
Sbjct: 61 RACERVGIKAEDYLLPGDATQEELLTLIDSLNKNKDVHAILLQLPLPKHFSPQETQEAME 120
Query: 401 AIAPEKDIDGFHIINIGRLCVDLPTIVPATALAVV 505
AI+P KD DGFH N+G+L + +VP T V+
Sbjct: 121 AISPTKDADGFHPYNMGKLMIGDEDLVPCTPHGVI 155
>UniRef50_Q83FS2 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Tropheryma whipplei|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Tropheryma whipplei (strain Twist)
(Whipple's bacillus)
Length = 295
Score = 107 bits (256), Expect = 2e-22
Identities = 52/147 (35%), Positives = 93/147 (63%)
Frame = +2
Query: 65 IMARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKF 244
++A++LDG A++ I + L + + + G P + ++VG++PAS +YV +K K
Sbjct: 1 MVAKVLDGLAVSAGIFERLHRACCELENNGV-CPKLATVLVGNNPASRSYVLSKHRDCKN 59
Query: 245 VGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDI 424
+GI + I ++ +E++L+S+++ LN + V GI+VQLP+P++I++ +V +AI P+KD
Sbjct: 60 IGIQSTLIELPANTSEKELISKVEILNASSDVSGIIVQLPLPESIDQNKVIEAINPDKDA 119
Query: 425 DGFHIINIGRLCVDLPTIVPATALAVV 505
DG H +N+G L IVP T +V
Sbjct: 120 DGLHPLNLGYLVTGKQGIVPCTPAGIV 146
>UniRef50_Q057D7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Enterobacteriaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Buchnera aphidicola subsp. Cinara cedri
Length = 284
Score = 107 bits (256), Expect = 2e-22
Identities = 52/144 (36%), Positives = 88/144 (61%)
Frame = +2
Query: 74 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 253
+ILDG ++ +I K++K+KI + + P + I++G++PAS YV K EA G
Sbjct: 4 KILDGLKISKKIIKKIKKKIEKRKKKRKKIPGLAMIVIGNNPASLIYVNKKREACNQAGF 63
Query: 254 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 433
++ + + I E +L++ I+ LN++ +DGIL+QLP+P IN ++ +I P+KD+DGF
Sbjct: 64 FSIYWHLSNQIEEIELINLIKKLNKNKCIDGILIQLPLPIKINYLKIITSIDPKKDVDGF 123
Query: 434 HIINIGRLCVDLPTIVPATALAVV 505
H N+G LC + P T+ V+
Sbjct: 124 HPYNLGSLCQNNPQFRSCTSKGVI 147
>UniRef50_Q6MI74 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Bdellovibrio bacteriovorus|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Bdellovibrio
bacteriovorus
Length = 288
Score = 107 bits (256), Expect = 2e-22
Identities = 53/146 (36%), Positives = 81/146 (55%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
M ILDGK +A E++ L ++A++ RAP + +IVGDD ASH YV+NK A + +
Sbjct: 1 MVLILDGKEVAKEVRASLVPRVAKFKETYGRAPQLSVVIVGDDKASHVYVKNKKIACEKI 60
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
G+ + ++ T+ +L + LN DN VDGILVQ P+P ++ V ++ EKD D
Sbjct: 61 GMTSTIHTLPAETTQSELNQILSKLNNDNGVDGILVQFPLPKHLSSDEVLKLVSAEKDAD 120
Query: 428 GFHIINIGRLCVDLPTIVPATALAVV 505
G ++G P + P T V+
Sbjct: 121 GLTYESLGYFFAGKPLVSPCTPAGVM 146
>UniRef50_A7DNA7 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=1; Candidatus Nitrosopumilus maritimus
SCM1|Rep: Methylenetetrahydrofolate dehydrogenase
(NADP(+)) - Candidatus Nitrosopumilus maritimus SCM1
Length = 287
Score = 105 bits (253), Expect = 4e-22
Identities = 56/142 (39%), Positives = 82/142 (57%)
Frame = +2
Query: 80 LDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDA 259
+DGK ++ +K +K+ + + + G P + ++VGD+PAS TYVRNK A + VGI
Sbjct: 6 IDGKVISQSVKDRVKKAVEELKNQGIN-PCLATVLVGDNPASATYVRNKHRACEEVGITT 64
Query: 260 LTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHI 439
D+ T+ QL I+NLN DNSV GILVQLP+P+ ++E I+P KD+DG
Sbjct: 65 KDHKLDASTTQAQLNEIIENLNNDNSVHGILVQLPLPEQLDEFTTTSRISPLKDVDGLTP 124
Query: 440 INIGRLCVDLPTIVPATALAVV 505
N G L + +V T V+
Sbjct: 125 HNAGLLAMKKAALVACTPSGVM 146
>UniRef50_Q5SJ94 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermus thermophilus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermus thermophilus (strain HB8 / ATCC
27634 / DSM 579)
Length = 282
Score = 105 bits (252), Expect = 6e-22
Identities = 61/145 (42%), Positives = 86/145 (59%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A++L G A + +E++ ++ SL + P++R I +G+DPAS YVR K + A+ +G
Sbjct: 3 AQVLSGHEAAEAVYEEIRARLR---SL-SFTPSLRVIRLGEDPASVAYVRLKDKRARALG 58
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
+ D+ EE LL I LN D VDGILVQLP+P I +RV +AI P KD+DG
Sbjct: 59 YRSQVEVYPEDLPEEALLERIAALNADEEVDGILVQLPLPPHIRTQRVLEAIHPLKDVDG 118
Query: 431 FHIINIGRLCVDLPTIVPATALAVV 505
FH +N+GRL + P T L VV
Sbjct: 119 FHPLNVGRLWSGGKGLFPCTPLGVV 143
>UniRef50_Q4FTX6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=24; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Psychrobacter arcticum
Length = 295
Score = 105 bits (252), Expect = 6e-22
Identities = 54/131 (41%), Positives = 81/131 (61%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A ILDGKALA +I+++L ++ + R P++ I+VGDDPAS TYVR K A + VG
Sbjct: 14 ATILDGKALAKQIEQQLSTRVDAIKAKTGRTPSLATILVGDDPASATYVRMKGNACQRVG 73
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
+D++ + S T +L+++I LN + V GIL+Q PVP I+ER + I KD+DG
Sbjct: 74 MDSIRVEMPSATTTAELMAKIDELNNNPDVHGILLQHPVPAHIDERACFEQIDLAKDVDG 133
Query: 431 FHIINIGRLCV 463
+ GR+ +
Sbjct: 134 VTCLGFGRMAM 144
>UniRef50_Q6ALZ5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=27; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Desulfotalea psychrophila
Length = 296
Score = 104 bits (249), Expect = 1e-21
Identities = 50/131 (38%), Positives = 79/131 (60%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A+I+ G + EI E+K + + P + I+VG+ PAS +YV K++ A +G
Sbjct: 3 AKIISGTEIRKEILGEIKDAVTEMKDKYGTVPGLVTILVGESPASMSYVSLKIKTALSLG 62
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
+ + + TE +LL+ I+ N D+S+ G+LVQLP+P INE+ + AI P+KD+D
Sbjct: 63 FYEVQESLSVETTEAELLALIEKYNNDDSIHGVLVQLPLPKHINEQNIITAIDPDKDVDA 122
Query: 431 FHIINIGRLCV 463
FH +NIGRL +
Sbjct: 123 FHPVNIGRLMI 133
>UniRef50_A3PVV6 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Actinobacteridae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycobacterium sp. (strain JLS)
Length = 288
Score = 103 bits (247), Expect = 2e-21
Identities = 55/149 (36%), Positives = 84/149 (56%)
Frame = +2
Query: 59 ASIMARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAA 238
+ + A LDGKA EI +LK+++A G R P + ++VGDDP S YVR K
Sbjct: 2 SGVGAITLDGKATRDEIFVDLKERVAALTEQG-RTPGLGTVLVGDDPGSQAYVRGKHSDC 60
Query: 239 KFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEK 418
VGI+++ + +DI++ +L + I LN + G +VQLP+P ++E + I P K
Sbjct: 61 AKVGINSIRRDLPADISQAELDATIDELNANPECTGYIVQLPLPKHLDENAALERIDPGK 120
Query: 419 DIDGFHIINIGRLCVDLPTIVPATALAVV 505
D DG H N+GRL ++ P +P T +V
Sbjct: 121 DADGLHPTNLGRLVLNEPAPLPCTPRGIV 149
>UniRef50_Q74J95 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Lactobacillus|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus johnsonii
Length = 283
Score = 102 bits (245), Expect = 4e-21
Identities = 48/130 (36%), Positives = 84/130 (64%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
M I++G+ +A ++ +E K ++ + G P I I+VGDDPAS Y RNK + A+ +
Sbjct: 1 MTNIINGRQIAKQLNQETKTRVDKLKEEGI-IPGIVVILVGDDPASVIYTRNKQKNAEKL 59
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
G+ ++ D+++ ++L I + N+D ++ IL+QLP+P +N+ + +AIAPEKD+D
Sbjct: 60 GMKSILRKFPKDVSQAEVLQAIHHYNDDPTIHAILIQLPLPKHLNQTELIEAIAPEKDVD 119
Query: 428 GFHIINIGRL 457
GF+ N+G+L
Sbjct: 120 GFNSKNVGKL 129
>UniRef50_Q7TU81 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Prochlorococcus marinus|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Prochlorococcus marinus subsp. pastoris
(strain CCMP 1378 / MED4)
Length = 298
Score = 100 bits (239), Expect = 2e-20
Identities = 51/146 (34%), Positives = 85/146 (58%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
M+ LDGK L++EI++ L+ I ++ R P + I +G+DPAS YV NK +A V
Sbjct: 1 MSLKLDGKKLSLEIEERLRNYILTNKTIAKRNPGLAVIRIGEDPASGVYVGNKEKACSRV 60
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
GI + + + ++++ + LN DN++DG+L+QLP+ +E+R+ I PEKD+D
Sbjct: 61 GIKSYIFHLKDTVEQKEVEQLLNKLNLDNNIDGMLLQLPISKKFDEQRLISFINPEKDVD 120
Query: 428 GFHIINIGRLCVDLPTIVPATALAVV 505
G + NIG+L + + T +V
Sbjct: 121 GLNEQNIGKLVKNEQAMRSCTPAGIV 146
>UniRef50_Q5FJG5 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Firmicutes|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Lactobacillus acidophilus
Length = 283
Score = 100 bits (239), Expect = 2e-20
Identities = 56/146 (38%), Positives = 83/146 (56%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
M +ILDGK +A + ++LK+K+ G P I +GDDPAS YVR K A+ +
Sbjct: 1 MGKILDGKFVANLLGEKLKEKVKDLKEEGI-TPHFCVINIGDDPASKIYVRTKKRRAEKM 59
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
GI +D +E L+ I LNED ++G++VQLP P+ I+ + + I P KD+D
Sbjct: 60 GIIQDIYQLPADTKQEVALNLIDKLNEDPDINGVMVQLPAPEQIDADELLERIDPNKDVD 119
Query: 428 GFHIINIGRLCVDLPTIVPATALAVV 505
G NIGR+ ++ I PATA ++
Sbjct: 120 GLTPSNIGRIWMENHFIEPATAEGII 145
>UniRef50_Q2B9L0 Cluster: Bifunctional protein FolD; n=1; Bacillus
sp. NRRL B-14911|Rep: Bifunctional protein FolD -
Bacillus sp. NRRL B-14911
Length = 322
Score = 99 bits (238), Expect = 3e-20
Identities = 54/146 (36%), Positives = 84/146 (57%), Gaps = 3/146 (2%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
ILDGK +A ++K+ L ++ G P + I+VGDDP+S TYVR K A +GI
Sbjct: 45 ILDGKRVAADVKEGLMPRVENLTQKGI-TPCLATILVGDDPSSETYVRMKGNACARLGIR 103
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 436
+ I+ + T E+L+ I+ LNE+ V GIL+Q PVP I+ER+ + I+ +KD+DG
Sbjct: 104 SERIHMPKETTTEELVKTIEELNENKEVHGILLQHPVPGHIDERKAFETISIDKDVDGVT 163
Query: 437 IINIGRLCVDL---PTIVPATALAVV 505
G+ + P+ PA +A++
Sbjct: 164 SHGYGQTALGFGTYPSCTPAAIMAII 189
>UniRef50_Q8RDM4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Fusobacterium nucleatum|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Fusobacterium nucleatum subsp. nucleatum
Length = 283
Score = 99 bits (238), Expect = 3e-20
Identities = 50/127 (39%), Positives = 78/127 (61%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
++DGK LA +IK ++K +I + N P + I+VGDDPAS Y+ ++V++ + +GI
Sbjct: 2 LMDGKELARDIKVKIKAEIDNIKKIHNINPMVATILVGDDPASQVYLNSQVKSYQDLGIG 61
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 436
+I+E LL+ I LN+D VDGI++ LP+P IN +V ++I KD+DGF
Sbjct: 62 VQKYFFSEEISEAYLLNLIDKLNKDTEVDGIMINLPLPPQINATKVLNSIKLIKDVDGFK 121
Query: 437 IINIGRL 457
N+G L
Sbjct: 122 AENLGLL 128
>UniRef50_A5IXS7 Cluster: FolD bifunctional protein; n=1; Mycoplasma
agalactiae|Rep: FolD bifunctional protein - Mycoplasma
agalactiae
Length = 286
Score = 99.1 bits (236), Expect = 5e-20
Identities = 55/146 (37%), Positives = 86/146 (58%), Gaps = 3/146 (2%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
IL+GK +A E ELK++ + L R P + I VGD+PAS Y++NK++ A+ +G+
Sbjct: 3 ILNGKIIAEERTVELKKEFEEITKLIGRQPVLSIIQVGDNPASSLYIKNKIKKAEELGVK 62
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF- 433
A D DI++ LL ++ LNE++ DGI+VQLP+P+ I+ + + + I EKD+DG
Sbjct: 63 ATLYKFDEDISQNSLLKKLDVLNEES--DGIIVQLPLPEHISPKVIMNGIRLEKDVDGLC 120
Query: 434 --HIINIGRLCVDLPTIVPATALAVV 505
N D + PATA A++
Sbjct: 121 EKSTFNFYNDKYDELSFTPATAAAII 146
>UniRef50_Q14NV1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Spiroplasma citri|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Spiroplasma citri
Length = 286
Score = 99.1 bits (236), Expect = 5e-20
Identities = 49/144 (34%), Positives = 85/144 (59%)
Frame = +2
Query: 74 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 253
+I+DGK ++ IK ++ ++I + + R P + I +G++ AS TY++NK A + VG+
Sbjct: 5 KIIDGKMVSELIKAKITEQILKIKAKKQRVPALTIIQIGNNKASTTYIKNKKIACEKVGV 64
Query: 254 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 433
+N ITE L+ I +LN ++ +D ILVQLP+P IN +V + I +KD+DGF
Sbjct: 65 TCKVLNYPDIITESALIKIINDLNNNSKIDAILVQLPLPSHINSEKVINTIITKKDVDGF 124
Query: 434 HIINIGRLCVDLPTIVPATALAVV 505
+G L + ++P+T ++
Sbjct: 125 TPKILGNLMLGHYNLLPSTPKGII 148
>UniRef50_A1HML1 Cluster: Methenyltetrahydrofolate cyclohydrolase;
n=1; Thermosinus carboxydivorans Nor1|Rep:
Methenyltetrahydrofolate cyclohydrolase - Thermosinus
carboxydivorans Nor1
Length = 279
Score = 96.3 bits (229), Expect = 4e-19
Identities = 52/146 (35%), Positives = 83/146 (56%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
MA ILDGKA+A K ++K K+ ++ N + ++VG+D AS Y V+ A +
Sbjct: 1 MALILDGKAVAAAYKAKIKAKVDA-LAAQNITCGLAILLVGNDAASRIYADRLVKLATGL 59
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
G+ A+ + +D TEE++L+ + LNED+ + GIL +P+P + RV A+AP+KD+D
Sbjct: 60 GVQAVVRHLPADATEEEVLALVCELNEDDHIHGILPMMPLPPHLATDRVAAALAPDKDVD 119
Query: 428 GFHIINIGRLCVDLPTIVPATALAVV 505
H +N G + P T AV+
Sbjct: 120 ALHPLNAGLVATGKSRWAPCTPRAVM 145
>UniRef50_A0JTZ0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=51; Actinobacteria (class)|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Arthrobacter sp. (strain FB24)
Length = 302
Score = 95.5 bits (227), Expect = 6e-19
Identities = 50/133 (37%), Positives = 80/133 (60%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A+ILDGKA A IK EL +++A+ + G P I ++VG DPAS YV K + + +G
Sbjct: 5 AKILDGKAAAAAIKSELAERVAKLKARGV-TPGIATVLVGADPASQLYVSMKHKQSVEIG 63
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
++++ +D T+ Q+ + I LN D + G +VQLP+P ++ + + I P KD DG
Sbjct: 64 MNSIQRELPADATQAQVEALIDELNADPACHGYIVQLPLPKHLDTDAILERIDPAKDADG 123
Query: 431 FHIINIGRLCVDL 469
H N+GRL +++
Sbjct: 124 LHPTNLGRLVLNV 136
>UniRef50_UPI00015B59A5 Cluster: PREDICTED: similar to
ENSANGP00000016878; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000016878 - Nasonia
vitripennis
Length = 866
Score = 94.7 bits (225), Expect = 1e-18
Identities = 50/142 (35%), Positives = 82/142 (57%), Gaps = 4/142 (2%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQ-WVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 253
+L G LA EI++ L + +A L N AP + + VG S+ Y+R K++AA +GI
Sbjct: 9 VLSGTDLAKEIRESLAKDVAAIQQKLPNYAPGLAIVQVGGREDSNVYIRMKIKAASEIGI 68
Query: 254 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVP--DTINERRVCDAIAPEKDID 427
A + + TE +LL+++ LN D GI+VQ+P+ + IN + D ++P+KD+D
Sbjct: 69 KATHVKMPNTTTEHELLTKLNKLNNDPDTHGIIVQMPLDSVNKINSHLITDTVSPDKDVD 128
Query: 428 GFHIINIGRLCV-DLPTIVPAT 490
G + IN GR+ + D+ +P T
Sbjct: 129 GLNTINEGRVAIGDMSGFLPCT 150
>UniRef50_Q54VK0 Cluster: Methenyl tetrahydrofolate cyclohydrolase /
NADP-dependent methylene H4F dehydrogenase; n=1;
Dictyostelium discoideum AX4|Rep: Methenyl
tetrahydrofolate cyclohydrolase / NADP-dependent
methylene H4F dehydrogenase - Dictyostelium discoideum
AX4
Length = 440
Score = 94.7 bits (225), Expect = 1e-18
Identities = 53/147 (36%), Positives = 83/147 (56%), Gaps = 5/147 (3%)
Frame = +2
Query: 80 LDGKALAMEI---KKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
LDGK LA I KK +K ++ P + I VGD +Y++ K + VG
Sbjct: 86 LDGKLLASHIVSSKKSIKADTEDFIKNSGVTPNLVVIYVGDSKQIESYIKAKRTGCEDVG 145
Query: 251 IDALTINR-DSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
T++R SDI E+QL+ +I+ +ED SV GI+VQLP+PD +N+ + +I P+KD+D
Sbjct: 146 FK-FTLDRFSSDIKEDQLIKKIKYHSEDPSVHGIIVQLPLPDNLNKDAIIQSIDPKKDVD 204
Query: 428 GFHIINIGRLCVD-LPTIVPATALAVV 505
G N+G++ + P +P T L ++
Sbjct: 205 GLTSTNLGQIMISKKPLYIPCTPLGIL 231
>UniRef50_Q8RAD0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermoanaerobacter|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoanaerobacter tengcongensis
Length = 280
Score = 93.9 bits (223), Expect = 2e-18
Identities = 48/143 (33%), Positives = 82/143 (57%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
I+DGK ++ IK+E+K++I ++ P + ++ GDD +S Y +KV+A + VGI+
Sbjct: 5 IIDGKEISNRIKEEVKREIQEF----GYKPRLAILMAGDDESSKVYANSKVKACESVGIE 60
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 436
A + S+ E++ ++ LNED GI++++P+P + +V D I P KD+D
Sbjct: 61 A-KVYYFSEKEEDKFFDTLEKLNEDKDTHGIMIEMPLPKGFDVDKVYDTINPYKDVDCIS 119
Query: 437 IINIGRLCVDLPTIVPATALAVV 505
N+GRL P VP T A++
Sbjct: 120 NYNMGRLFAGKPLFVPCTPKAII 142
>UniRef50_Q9HPY4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; cellular organisms|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Halobacterium salinarium (Halobacterium
halobium)
Length = 297
Score = 93.5 bits (222), Expect = 2e-18
Identities = 49/141 (34%), Positives = 74/141 (52%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
M I+DG A+A +++ +L + + G P + +++ D AS TYV K + + V
Sbjct: 1 MTEIIDGDAVAAQLRADLTGAVETLETAGV-TPRLATVLMNDKQASETYVSMKQQDCEEV 59
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
GI A + D + + + L + LN V GILVQ P PD + + RV A+ P KD+D
Sbjct: 60 GIAAEDVRIDPEASADTLFDTVAELNAREDVHGILVQDPTPDHVPDERVLSAVDPAKDVD 119
Query: 428 GFHIINIGRLCVDLPTIVPAT 490
GFH N+G+L P P T
Sbjct: 120 GFHPENVGKLVGGTPRFKPCT 140
>UniRef50_P11586 Cluster: C-1-tetrahydrofolate synthase, cytoplasmic
(C1-THF synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)]; n=86; cellular organisms|Rep:
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF
synthase) [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate
synthetase (EC 6.3.4.3)] - Homo sapiens (Human)
Length = 935
Score = 93.5 bits (222), Expect = 2e-18
Identities = 52/132 (39%), Positives = 80/132 (60%), Gaps = 3/132 (2%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVS-LGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
A IL+GK ++ +I+ LK ++ Q + P + + VG+ S+ Y+ K++AA+ +
Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPV--PDTINERRVCDAIAPEKD 421
GI A I TE +++ I +LNED++V G LVQLP+ ++IN V +AIAPEKD
Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123
Query: 422 IDGFHIINIGRL 457
+DG IN GRL
Sbjct: 124 VDGLTSINAGRL 135
>UniRef50_O84081 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=7; Chlamydiaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Chlamydia trachomatis
Length = 287
Score = 93.1 bits (221), Expect = 3e-18
Identities = 46/144 (31%), Positives = 82/144 (56%), Gaps = 1/144 (0%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
+L G A I +K+ I ++AP + +++G++PAS YV K++ A +G+
Sbjct: 2 LLKGAPAADHILATIKENIRAC----SKAPGLAVVLIGNNPASEIYVNMKIKRATDLGMV 57
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 436
+ + + SD T +L+ I LN D ++ GILVQLP+P ++ + + I P+KD+DG H
Sbjct: 58 SKSYRKPSDATLSDILALIHQLNNDENIHGILVQLPLPKHLDAQAILSTITPDKDVDGLH 117
Query: 437 IINIGRLCV-DLPTIVPATALAVV 505
+N+G+L + + +P T +V
Sbjct: 118 PVNVGKLLLGETDGFIPCTPAGIV 141
>UniRef50_Q0AZF5 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 277
Score = 92.7 bits (220), Expect = 4e-18
Identities = 50/143 (34%), Positives = 83/143 (58%), Gaps = 2/143 (1%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
I+ G +A EI+++LK+K + +P + I+VG YV K +AA G
Sbjct: 3 IISGSQIAQEIRQKLKEKNER----EGISPCLAMILVGGQKEDLHYVGLKEKAATATGGK 58
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINER--RVCDAIAPEKDIDG 430
+ ++ D ++++L+++I LN+D VDGIL+QLP+P + E+ + AI P+KD+DG
Sbjct: 59 SRLLHLPEDTSQQELMAKIAELNQDEQVDGILLQLPLPAALEEQTDEILAAIRPDKDVDG 118
Query: 431 FHIINIGRLCVDLPTIVPATALA 499
F ++N GR+ D P + ALA
Sbjct: 119 FSLVNRGRMSGDRPGFISCAALA 141
>UniRef50_Q97HC9 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=8; Clostridium|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium acetobutylicum
Length = 278
Score = 91.9 bits (218), Expect = 8e-18
Identities = 50/146 (34%), Positives = 81/146 (55%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
M I++GKA + + K ++ + I + G P I I VGDD S YV N+ + ++ +
Sbjct: 1 MGDIINGKAESQKYKDKIIEFINERKKQGLDIPCIASITVGDDGGSLYYVNNQKKVSESL 60
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
GI+ +I D I EE+L+ I+ LN DN + GI++QLP+P+ I+ + V I KDID
Sbjct: 61 GIEFKSIFLDESIREEELIKLIEGLNVDNKIHGIMLQLPLPNHIDAKLVTSKIDANKDID 120
Query: 428 GFHIINIGRLCVDLPTIVPATALAVV 505
IN G+ + +P T +++
Sbjct: 121 SLTDINTGKFYKGEKSFIPCTPRSII 146
>UniRef50_Q6BNW9 Cluster: Debaryomyces hansenii chromosome E of
strain CBS767 of Debaryomyces hansenii; n=2;
Debaryomyces hansenii|Rep: Debaryomyces hansenii
chromosome E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 276
Score = 90.6 bits (215), Expect = 2e-17
Identities = 44/98 (44%), Positives = 62/98 (63%)
Frame = +2
Query: 164 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 343
P + I VG P S YV+ K++AAK I + + D D++EE LL EI LN+D V+
Sbjct: 76 PNLTIIQVGGRPDSSAYVKAKLKAAKSSNILSSLLKFDEDMSEEDLLEEIDRLNKDPKVN 135
Query: 344 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 457
G+L+QLP+P NE + +A+A EKD+DGF N+G L
Sbjct: 136 GLLIQLPLPKHFNETLITNAVATEKDVDGFARYNVGEL 173
>UniRef50_Q3A1Q7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Bacteria|Rep: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
Length = 290
Score = 90.6 bits (215), Expect = 2e-17
Identities = 46/144 (31%), Positives = 79/144 (54%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A++L+GK +A + +++ +++A G +P + I+VGDD S +YV K E K VG
Sbjct: 3 AQLLEGKVVAAAVLEDVARRVAVLKDKGI-SPGLGTILVGDDGPSVSYVNKKRETCKQVG 61
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
I + + T+ LL+ +++ N+ VD ++Q P+P + + + PEKD DG
Sbjct: 62 IASFHNEIPASATQSDLLAAVRDFNDSPDVDAYIIQYPLPKGFDFNEALNLMLPEKDADG 121
Query: 431 FHIINIGRLCVDLPTIVPATALAV 502
H +N+GRL + P VP T +
Sbjct: 122 LHPVNLGRLVLQEPGPVPCTPAGI 145
>UniRef50_Q0SFQ8 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Actinomycetales|Rep: Bifunctional protein folD 1
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhodococcus sp. (strain RHA1)
Length = 297
Score = 88.6 bits (210), Expect = 7e-17
Identities = 52/146 (35%), Positives = 77/146 (52%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
M R L G LA I+ + A LG R P + + DD ++ YVR+ AAK
Sbjct: 1 MTRSLGGAELATSIRNDASVAAAALNDLGTR-PKLAVVQATDDESTAWYVRSIASAAKRT 59
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
GI ++ + + EQ+ S + L D V GI++Q P+PD + + +AI P KD+D
Sbjct: 60 GILCDIVDLGAAASTEQIRSTLVELGHDPDVHGIILQTPLPDGTDLDALREAINPAKDVD 119
Query: 428 GFHIINIGRLCVDLPTIVPATALAVV 505
G + +++GRL LP PATA AV+
Sbjct: 120 GANPVSLGRLVARLPAFAPATAQAVI 145
>UniRef50_A5CF58 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Orientia tsutsugamushi Boryong|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Orientia tsutsugamushi
(strain Boryong) (Rickettsia tsutsugamushi)
Length = 301
Score = 86.2 bits (204), Expect = 4e-16
Identities = 55/147 (37%), Positives = 80/147 (54%), Gaps = 1/147 (0%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
M I+DGK LA E K + + I+VG++ AS YV NKV AK +
Sbjct: 1 MTVIMDGKKLAELRLIETKNDLLALKDKYQITVKLVIILVGNNDASLIYVNNKVAKAKAI 60
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
G+D+ I I E++L S I +LN D++V GI+VQLP+P I+ ++ I KD+D
Sbjct: 61 GMDSEIIRLFEFIEEKKLFSVIDDLNCDSTVHGIIVQLPLPPHIDALKLFARIDSRKDVD 120
Query: 428 GFHIINIGRLCVDL-PTIVPATALAVV 505
G + INIG L + ++P TAL +
Sbjct: 121 GLNPINIGYLNIGANQGLIPCTALGCI 147
>UniRef50_A5V1H2 Cluster: Methylenetetrahydrofolate dehydrogenase
(NADP(+)); n=5; Chloroflexi (class)|Rep:
Methylenetetrahydrofolate dehydrogenase (NADP(+)) -
Roseiflexus sp. RS-1
Length = 288
Score = 85.8 bits (203), Expect = 5e-16
Identities = 45/140 (32%), Positives = 72/140 (51%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A ILDG+ALA +++EL+ ++ AP++ + + DPAS Y R + + +G
Sbjct: 3 AIILDGRALAKTLREELRADTQAFIQNNGIAPSLAVVKIAGDPASDRYTRTIRKGCEEIG 62
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
I + T+ L I L+ D ++ GIL+ LP+P ++ R I P KD+DG
Sbjct: 63 ITFTDHTLPPETTQAMLEETISALSFDRTIHGILLHLPLPPGLDSARAIAQIDPAKDVDG 122
Query: 431 FHIINIGRLCVDLPTIVPAT 490
H N G L + P ++P T
Sbjct: 123 VHPYNAGLLAMGRPGLIPNT 142
>UniRef50_A0C3Q0 Cluster: Chromosome undetermined scaffold_147,
whole genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_147,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 404
Score = 84.6 bits (200), Expect = 1e-15
Identities = 44/116 (37%), Positives = 70/116 (60%), Gaps = 2/116 (1%)
Frame = +2
Query: 164 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 343
P + +VGD PAS +YV K++A + + +DA N ++ +EQL+ IQ +N D
Sbjct: 141 PKLGICLVGDSPASKSYVNRKLKACQEINVDAEVFNFSENVGQEQLIKHIQQMNH----D 196
Query: 344 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV--DLPTIVPATALAVV 505
GILVQLP+P +N+ + +I EKD+D H+ N+ R+ V +L ++P T AV+
Sbjct: 197 GILVQLPLPSHLNKLDIIHSIPYEKDVDCLHMHNLQRILVYGELCEMLPCTPAAVL 252
>UniRef50_Q1AVQ0 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Rubrobacter xylanophilus DSM 9941|Rep: Bifunctional
protein folD 2 [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Rubrobacter xylanophilus
(strain DSM 9941 / NBRC 16129)
Length = 320
Score = 83.0 bits (196), Expect = 4e-15
Identities = 48/143 (33%), Positives = 75/143 (52%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
AR++DG+ +A E+KK + ++ + G R P + ++VG+D A+ Y R A +G
Sbjct: 3 ARVIDGRPIAGELKKRVASEVEGLAARGVR-PGLATVLVGEDYAARAYERRVGGLAAELG 61
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
+ + E +L+ + LN D V GILV P+P I+E V A+ P KDI+
Sbjct: 62 CRYVCERLPREAEEADVLAVVGKLNADPRVSGILVLRPLPGHISEPAVFSALDPLKDIEA 121
Query: 431 FHIINIGRLCVDLPTIVPATALA 499
H +N G L + P VP+T A
Sbjct: 122 VHPVNAGLLALGRPRYVPSTPAA 144
>UniRef50_Q0AWX5 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Syntrophomonas wolfei subsp. wolfei str.
Goettingen|Rep: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Syntrophomonas wolfei subsp. wolfei (strain Goettingen)
Length = 272
Score = 82.6 bits (195), Expect = 5e-15
Identities = 46/143 (32%), Positives = 80/143 (55%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
++ GK + +IK+ ++Q A+ V +G + I VGDDP+S YVR + A+ G+
Sbjct: 2 LIYGKDIREQIKERVRQS-AEEVKMG-----LAIIRVGDDPSSMAYVRGIRKFAEETGVK 55
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 436
+N + E +LL I +LN + + GI++Q P+P ++N + +AI +KD++G H
Sbjct: 56 VEIVNLPDAVGERELLKTIGDLNNSSEITGIMLQTPLPASLNASHLVNAIDFDKDVEGIH 115
Query: 437 IINIGRLCVDLPTIVPATALAVV 505
N+G+L + P T AV+
Sbjct: 116 NYNLGKLISKEEGVRPCTPKAVI 138
>UniRef50_Q979W3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermoplasma volcanium
Length = 281
Score = 82.2 bits (194), Expect = 6e-15
Identities = 45/144 (31%), Positives = 85/144 (59%)
Frame = +2
Query: 74 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 253
++L G+ +A + +ELK++I + +P + + VG+ A+ Y R K++ K +G
Sbjct: 4 KLLKGEEIAEKKAEELKERIEKM----GVSPRLVLLQVGNYSAATIYARAKIKRGKKIGA 59
Query: 254 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 433
D + + + D+T+++L+ I+ L+ D V+GI+V+ P+P TI+ + +I KD+D
Sbjct: 60 DVV-LEKYEDLTKQELVRRIEELSADKDVNGIMVENPLPKTIDYYDIVKSIPYYKDVDAL 118
Query: 434 HIINIGRLCVDLPTIVPATALAVV 505
N G + ++ +VPATA+AVV
Sbjct: 119 SPYNQGSIAINREFLVPATAMAVV 142
>UniRef50_UPI00006CCCC6 Cluster: methylenetetrahydrofolate
dehydrogenase; n=1; Tetrahymena thermophila SB210|Rep:
methylenetetrahydrofolate dehydrogenase - Tetrahymena
thermophila SB210
Length = 342
Score = 80.6 bits (190), Expect = 2e-14
Identities = 43/123 (34%), Positives = 72/123 (58%), Gaps = 2/123 (1%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIA--QWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
+ +G A +I L+++I Q S +R P + I+VG++PAS +Y++ K++A + +G
Sbjct: 18 VFNGNKSAKKILSSLRKEIEWFQKQSDLSRKPGLGIILVGNNPASLSYIKKKLQACEAIG 77
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
I + DI E +LS I NLN + +D I+ QLP+P I++ V + I+ EKD DG
Sbjct: 78 IRHELYHFSEDIQEYDVLSAIDNLNRKDDIDAIMAQLPLPSHIDKNNVINMISSEKDADG 137
Query: 431 FHI 439
+
Sbjct: 138 LKL 140
>UniRef50_Q2JCX4 Cluster: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Frankia|Rep: Bifunctional protein folD 1 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] -
Frankia sp. (strain CcI3)
Length = 276
Score = 79.8 bits (188), Expect = 3e-14
Identities = 46/144 (31%), Positives = 78/144 (54%)
Frame = +2
Query: 74 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 253
R+LDG+++A EI + + + A+ ++ PT+ ++ DPA+++Y A VG+
Sbjct: 2 RMLDGRSMAAEIGRYVVDE-AERLAAAGVTPTLAVVLPTADPAAYSYAEIIERTAGKVGV 60
Query: 254 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 433
+ + +L I + D +V GI+VQ P+P + R V + I KD+DG
Sbjct: 61 HCVLHEPKGE--PAAILDTIDTVAADPTVHGIIVQTPLPGGLTSREVGEHIPTAKDVDGM 118
Query: 434 HIINIGRLCVDLPTIVPATALAVV 505
+ ++GRL + LP+ PATA AVV
Sbjct: 119 NPSSLGRLALGLPSFAPATAAAVV 142
>UniRef50_Q4A6B1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma synoviae 53|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma synoviae (strain 53)
Length = 278
Score = 79.4 bits (187), Expect = 4e-14
Identities = 54/148 (36%), Positives = 84/148 (56%), Gaps = 4/148 (2%)
Frame = +2
Query: 74 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI 253
+IL G+ A + K+LK+++ + ++L NR + I VGD S+ YV K++ AK +GI
Sbjct: 2 KILSGREKAEQDLKQLKKELDE-LNL-NRPIKLAIIQVGDKMESNRYVEQKLKKAKEIGI 59
Query: 254 DALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 433
+A D +IT+++LL + +NE + DGIL+QLP+P + + + DA+ EKDIDG
Sbjct: 60 EAKCFKFDENITQKRLLLAMDEINE--NWDGILIQLPLPKHLPKEVILDAVPYEKDIDGL 117
Query: 434 ----HIINIGRLCVDLPTIVPATALAVV 505
I D VPA A AV+
Sbjct: 118 SHRNEFILYNEKNSDDKFFVPAAARAVL 145
>UniRef50_Q4DH06 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein, putative; n=1; Trypanosoma
cruzi|Rep: Methylenetetrahydrofolate dehydrogenase-like
protein, putative - Trypanosoma cruzi
Length = 375
Score = 79.0 bits (186), Expect = 6e-14
Identities = 42/132 (31%), Positives = 76/132 (57%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A IL G+ L+ + + ++ ++A+ + +P++ ++VG+ S YV K A+ G
Sbjct: 3 AEILLGRPLSGTLIERIQHEVARL----SCSPSLAVVMVGNRQDSRRYVSVKQRTAEACG 58
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
I ++ ++EE+L E++ +++DN+ DG+L+QLP+P + R I P KD+DG
Sbjct: 59 IRFHLLSLPETVSEERLHQELRRISDDNAFDGVLLQLPIPSHLRVRPALLCIHPGKDVDG 118
Query: 431 FHIINIGRLCVD 466
H IN G L +D
Sbjct: 119 LHPINAGSLFLD 130
>UniRef50_O51057 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Borrelia burgdorferi group|Rep: Bifunctional
protein folD [Includes: Methylenetetrahydrofolate
dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate
cyclohydrolase (EC 3.5.4.9)] - Borrelia burgdorferi
(Lyme disease spirochete)
Length = 308
Score = 78.6 bits (185), Expect = 8e-14
Identities = 44/148 (29%), Positives = 84/148 (56%), Gaps = 1/148 (0%)
Frame = +2
Query: 65 IMARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKF 244
I++ + +GK A + LK+ + Q +L ++ ++ ++ D+PAS+ YV K AK
Sbjct: 7 ILSIVFNGKDFANKYYLMLKEFLKQH-NLRDKI-ALKVVLANDEPASNLYVSIKSRVAKE 64
Query: 245 VGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDI 424
+G++ I ++ + +L I N++ S DGI+VQLP+ ++ + ++I KD+
Sbjct: 65 IGLNVEVIKFSANSVQSDILEVIDRENKNLSTDGIIVQLPLLKGMDLNSILNSIVYSKDV 124
Query: 425 DGFHIINIGRLCV-DLPTIVPATALAVV 505
DG +N+G++ + D +P TALAV+
Sbjct: 125 DGLSFVNLGKMILGDKKGFIPCTALAVL 152
>UniRef50_Q21285 Cluster: Dauer or aging adult overexpression
protein 3; n=2; Caenorhabditis|Rep: Dauer or aging adult
overexpression protein 3 - Caenorhabditis elegans
Length = 303
Score = 78.2 bits (184), Expect = 1e-13
Identities = 47/134 (35%), Positives = 72/134 (53%), Gaps = 3/134 (2%)
Frame = +2
Query: 65 IMARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCII-VGDDPASHTYVRNKVEAAK 241
++A I+ G + ++ ++ QKIA+ + I+ VG+ S+ Y+ +K++ AK
Sbjct: 1 MVAEIVSGLEYSKKVLHDVGQKIAKTREHHPNFHAVLAIVQVGNRSDSNVYINSKLKKAK 60
Query: 242 FVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPV--PDTINERRVCDAIAPE 415
+G D I IT+ L EI LN DN +DGI++QLP+ I+ V D I P
Sbjct: 61 EIGADGKLIKLPDTITQGDLKREIMALNHDNEIDGIIIQLPLDCKHEIDADSVIDLIDPL 120
Query: 416 KDIDGFHIINIGRL 457
KD+DG IN GRL
Sbjct: 121 KDVDGLTRINAGRL 134
>UniRef50_Q04FB7 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Leuconostocaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Oenococcus oeni (strain BAA-331 / PSU-1)
Length = 285
Score = 77.8 bits (183), Expect = 1e-13
Identities = 49/148 (33%), Positives = 79/148 (53%), Gaps = 2/148 (1%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
M +ILDG++++ +I +E+K K+A+ + I ++ S YV K+ A F
Sbjct: 1 MVQILDGRSVSKKILQEVKDKVAK----AGFPVKLATIYNEENEGSKMYVGMKIRRATFA 56
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
G+ ++ D+ + +L + LN D+S+ GILVQ P+ D I+E ++ +AI P KD D
Sbjct: 57 GLISVEYKVDNSWKTDDILRLLSKLNMDSSICGILVQSPLGDGIDESKIFNAIDPLKDAD 116
Query: 428 GFHIINIGRLCVDLPT--IVPATALAVV 505
G N G L + IVPAT V+
Sbjct: 117 GLSAFNQGLLFENAKENYIVPATPAGVI 144
>UniRef50_O65269 Cluster: F6N23.28 protein; n=1; Arabidopsis
thaliana|Rep: F6N23.28 protein - Arabidopsis thaliana
(Mouse-ear cress)
Length = 310
Score = 75.8 bits (178), Expect = 5e-13
Identities = 42/127 (33%), Positives = 72/127 (56%), Gaps = 3/127 (2%)
Frame = +2
Query: 119 LKQKIAQW-VSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEE 295
L+ + W +L R+ + IV D A +R+ ++ +++ + D +EE
Sbjct: 34 LRTTASTWRCTLSIRSSSSPSAIVIDGKAEAKKIRDDIKIEVSRMKESIGVVPAEDSSEE 93
Query: 296 QLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV--DL 469
++L + N+D SV G+LVQLP+P ++E+ + +A++ EKD+DGFH +NIGRL +
Sbjct: 94 EVLKYVSGFNDDPSVHGVLVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLAMRGRE 153
Query: 470 PTIVPAT 490
P VP T
Sbjct: 154 PLFVPCT 160
>UniRef50_Q4QBW1 Cluster: Methylenetetrahydrofolate
dehydrogenase-like protein; n=2; Leishmania|Rep:
Methylenetetrahydrofolate dehydrogenase-like protein -
Leishmania major
Length = 207
Score = 75.4 bits (177), Expect = 7e-13
Identities = 39/115 (33%), Positives = 63/115 (54%)
Frame = +2
Query: 107 IKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDI 286
I K+L+Q+I S+ R P + ++VGD S YV +K+ AA GI+ ++ + +
Sbjct: 40 ISKQLRQRIRASTSVLRRPPCLVVVLVGDGADSIHYVNHKMRAAADCGIEVRLVHLSATV 99
Query: 287 TEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIG 451
+ +L + +N+D VD +L+QLP+P R I P KD+DG H +N G
Sbjct: 100 QQIELHRTLAAVNDDVEVDAVLLQLPLPPHQRTRSALVHIHPGKDVDGLHPLNAG 154
>UniRef50_Q189R8 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=11; Clostridiales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Clostridium difficile (strain 630)
Length = 290
Score = 75.4 bits (177), Expect = 7e-13
Identities = 47/149 (31%), Positives = 78/149 (52%), Gaps = 1/149 (0%)
Frame = +2
Query: 62 SIMARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAK 241
S +I+ GK +A +I +EL +++ V G P + + VG +Y R ++ +
Sbjct: 5 STKGQIIKGKPVADKISEELIKEVDLLVKEGIN-PKLTIVRVGARSDDLSYERGALKRCQ 63
Query: 242 FVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKD 421
+GI + DIT+E+ + ++ +N+D +V+GIL P+P +NE + IAPEKD
Sbjct: 64 NIGITTEVLELAEDITQEEYIDVLKRVNDDKNVNGILCFRPLPKHLNEEVIKYVIAPEKD 123
Query: 422 IDGFHIINIGRLCV-DLPTIVPATALAVV 505
+D F IN ++ D P T AVV
Sbjct: 124 VDCFSPINSAKVMEGDKSGFPPCTPTAVV 152
>UniRef50_Q4T2B9 Cluster: Chromosome undetermined SCAF10300, whole
genome shotgun sequence; n=6; Clupeocephala|Rep:
Chromosome undetermined SCAF10300, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 348
Score = 74.9 bits (176), Expect = 9e-13
Identities = 37/93 (39%), Positives = 58/93 (62%), Gaps = 2/93 (2%)
Frame = +2
Query: 185 VGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLP 364
VGD S+ Y+ K++AA +GIDA + S T+E++L I ++NED SV G++VQLP
Sbjct: 89 VGDRDDSNLYISAKMKAAAEIGIDAKHVRLPSSATQEEVLLNILSINEDQSVHGLIVQLP 148
Query: 365 VPDT--INERRVCDAIAPEKDIDGFHIINIGRL 457
+ I+ + + ++ +KD+DG IN GRL
Sbjct: 149 LDSVHHIDSECITNTVSADKDVDGLSCINAGRL 181
>UniRef50_Q987T6 Cluster: Bifunctional protein folD 2 [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=5; Alphaproteobacteria|Rep: Bifunctional protein folD
2 [Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Rhizobium loti (Mesorhizobium loti)
Length = 306
Score = 74.9 bits (176), Expect = 9e-13
Identities = 49/145 (33%), Positives = 73/145 (50%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
+R L G +A I +++ A + G P + I VGD A YVRN+ A+ G
Sbjct: 7 SRYLKGGPVAQRIIAAVREDAAIAKAEGF-PPKLISITVGDTDAVDVYVRNQRAKAQLAG 65
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
ID + IT +L + I LN D V GI++Q PVP I+ + + A+ P KD++G
Sbjct: 66 IDFEERRFPATITSGELEAAIHGLNADPRVTGIIIQRPVPAHISVKTLQAAVHPLKDVEG 125
Query: 431 FHIINIGRLCVDLPTIVPATALAVV 505
H +IG + + + P TA A V
Sbjct: 126 MHPASIGNIVYNQLDLAPCTAAASV 150
>UniRef50_A7AXK7 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus gnavus ATCC 29149|Rep: Putative
uncharacterized protein - Ruminococcus gnavus ATCC 29149
Length = 276
Score = 73.3 bits (172), Expect = 3e-12
Identities = 38/108 (35%), Positives = 63/108 (58%)
Frame = +2
Query: 110 KKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDIT 289
KKELK++I ++ P + I + DD AS++Y++ K + +GI+ +N S+ T
Sbjct: 16 KKELKEEIKHL----DKKPVLAVIQIDDDQASNSYIKGKQKDCDEIGIEMRHVNIYSNTT 71
Query: 290 EEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 433
E++ + + + DGI++QLP+PD N R+ I PEKD+DGF
Sbjct: 72 EQKEVECVITDIAKSDADGIIIQLPIPDKYNLERLQHLIPPEKDVDGF 119
>UniRef50_Q6L046 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Thermoplasmatales|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Picrophilus torridus
Length = 276
Score = 72.9 bits (171), Expect = 4e-12
Identities = 45/143 (31%), Positives = 78/143 (54%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
I+DG ++ + LK +I + + G P ++ I++G+D S Y + K+ +GID
Sbjct: 2 IIDGVKISETKMERLKNEIEKIKNTGIN-PKMKIILIGNDYGSVVYSKAKMRRGSKLGID 60
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 436
+ ++R I+ E L+ ++ ++ + + GI+++ PVP IN V + I KD+DG
Sbjct: 61 -VDLDRYDSISREDLIKLLKRYSQSDDIHGIMIETPVPG-INYYDVVNEIPFYKDVDGMT 118
Query: 437 IINIGRLCVDLPTIVPATALAVV 505
N+G L + I PATA AVV
Sbjct: 119 SYNLGNLYLKNEFIAPATARAVV 141
>UniRef50_UPI00006CB712 Cluster: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain;
n=1; Tetrahymena thermophila SB210|Rep: tetrahydrofolate
dehydrogenase/cyclohydrolase, NAD(P)-binding domain -
Tetrahymena thermophila SB210
Length = 377
Score = 70.9 bits (166), Expect = 2e-11
Identities = 38/110 (34%), Positives = 64/110 (58%), Gaps = 1/110 (0%)
Frame = +2
Query: 104 EIKKELKQKIAQWVSLGN-RAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDS 280
+I K++ QK+ + + N R P + I+VG+ S +YV K A K VG+ + I+
Sbjct: 35 KISKDVLQKVKERILRVNIREPKLAIILVGNAADSISYVSVKQRACKRVGVQSELIHLPE 94
Query: 281 DITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
T+++++ +++LN+ VD IL QLP P I++ V + I P KD+DG
Sbjct: 95 TTTQKEVIQIVEDLNKREDVDSILTQLPFPAQISKTIVINQIEPSKDVDG 144
>UniRef50_UPI0000D9D4E1 Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=2; Catarrhini|Rep: PREDICTED:
similar to Bifunctional methylenetetrahydrofolate
dehydrogenase/cyclohydrolase, mitochondrial precursor -
Macaca mulatta
Length = 111
Score = 70.1 bits (164), Expect = 3e-11
Identities = 29/61 (47%), Positives = 46/61 (75%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A ++ G+ LA EIK+E++Q++ +WV+ GN+ P + I+VG++PASH+YV NK AA VG
Sbjct: 37 AVVISGRKLAQEIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAADVG 96
Query: 251 I 253
+
Sbjct: 97 M 97
>UniRef50_Q9X288 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Thermotogaceae|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Thermotoga maritima
Length = 271
Score = 70.1 bits (164), Expect = 3e-11
Identities = 40/142 (28%), Positives = 80/142 (56%)
Frame = +2
Query: 80 LDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDA 259
+D K +A I++ K+++ + LG P + + DDP++ +Y++++ + A+ +GI
Sbjct: 3 IDCKTIARSIEERTKERVEK---LGF-TPKLVSVACTDDPSALSYLKSQRKKAEKLGIAF 58
Query: 260 LTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHI 439
+N ++ E+++S ++ L D SV+G+ V P P ++E+ + ++ EKD++G +
Sbjct: 59 EIMN----VSPEEIVSTLKKLGSDESVNGVFVARPFPLGLDEKEILSSVPVEKDVEGVNP 114
Query: 440 INIGRLCVDLPTIVPATALAVV 505
N+G L D P TA A V
Sbjct: 115 ANLGLLLYDEEIFPPCTAEAAV 136
>UniRef50_A0DMT9 Cluster: Chromosome undetermined scaffold_57, whole
genome shotgun sequence; n=2; Paramecium
tetraurelia|Rep: Chromosome undetermined scaffold_57,
whole genome shotgun sequence - Paramecium tetraurelia
Length = 309
Score = 69.3 bits (162), Expect = 5e-11
Identities = 39/116 (33%), Positives = 65/116 (56%), Gaps = 2/116 (1%)
Frame = +2
Query: 164 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 343
P + I VG++P+S TYVR K+ + I + I++++++ I++LN+ S+D
Sbjct: 37 PGLAIIQVGNNPSSLTYVRKKIALCEEHQIHHELYHFPETISQKEIVHRIKSLNQKGSID 96
Query: 344 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCV--DLPTIVPATALAVV 505
GILVQLP+P ++ + + I KDID H+ N L + I+P T AV+
Sbjct: 97 GILVQLPLPPHLSRLEISNEIKLNKDIDCLHMANFQNLLQNGEDNDIIPCTPAAVL 152
>UniRef50_A6LP88 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase; n=1; Thermosipho
melanesiensis BI429|Rep: Tetrahydrofolate
dehydrogenase/cyclohydrolase - Thermosipho melanesiensis
BI429
Length = 271
Score = 68.9 bits (161), Expect = 6e-11
Identities = 46/143 (32%), Positives = 76/143 (53%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
I+D K L +IK L ++I + R P + + DP++ +Y++++ +AAK G+D
Sbjct: 2 IIDVKPLYEDIKVNLLKRIEKL----KRTPKLVAVTFKPDPSTVSYLKSQEKAAKRFGLD 57
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 436
+S ++L+E L+ DN+V+GI V P+ +NE + + + P KDI+G H
Sbjct: 58 YEIFEGNSPKGVLKILAE---LSRDNNVNGIFVTHPLSQ-VNEMEIFENLVPSKDIEGRH 113
Query: 437 IINIGRLCVDLPTIVPATALAVV 505
N+G L P TA AVV
Sbjct: 114 PYNLGMLAYGEEFFAPCTAEAVV 136
>UniRef50_Q86F84 Cluster: Clone ZZD1003 mRNA sequence; n=1;
Schistosoma japonicum|Rep: Clone ZZD1003 mRNA sequence -
Schistosoma japonicum (Blood fluke)
Length = 332
Score = 67.3 bits (157), Expect = 2e-10
Identities = 46/131 (35%), Positives = 68/131 (51%), Gaps = 2/131 (1%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
IL G+ +A + ++K +A S + P + I VG+ P S Y++ K + AK GI
Sbjct: 6 ILYGRQVAQAVGHKIKLDVALLKSSFDVYPKLVVIEVGELPQSKLYIKQKFKFAKKYGIL 65
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPV-PDT-INERRVCDAIAPEKDIDG 430
+ S I+E LL + LN D+SV GI +QLP DT IN +A+A KD++G
Sbjct: 66 LSHMRLPSHISESLLLDYVYKLNADSSVHGITLQLPFDSDTNINVTNSLNAVATHKDVEG 125
Query: 431 FHIINIGRLCV 463
+ N L V
Sbjct: 126 LNSYNTALLSV 136
>UniRef50_Q8EV80 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma penetrans|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma penetrans
Length = 282
Score = 66.1 bits (154), Expect = 4e-10
Identities = 33/97 (34%), Positives = 53/97 (54%)
Frame = +2
Query: 164 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 343
P + + + DD AS YV K++ A +G+ I+ T++ L+ +I LN D+S+D
Sbjct: 30 PHMAIVKINDDAASDKYVSIKLKKAAELGVKTTLISEGIK-TQDDLIKQIHILNNDDSID 88
Query: 344 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGR 454
G ++QLP+P + +C+ I KDIDG I R
Sbjct: 89 GYIIQLPLPKGFDSNVICEHIDVNKDIDGLSSFAISR 125
>UniRef50_Q6KID0 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma mobile|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma mobile
Length = 280
Score = 65.7 bits (153), Expect = 6e-10
Identities = 43/143 (30%), Positives = 75/143 (52%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
ILDGK L+ + LK+K+ Q+ P + VG+ +S+ Y++ K++ A +G+
Sbjct: 3 ILDGKKLSQKDTIFLKEKVNQF----KIKPVFTIVQVGNLFSSNKYIKTKMDKALEIGVV 58
Query: 257 ALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFH 436
+ I I+E+ L+S I+ E G++VQLP+P ++ ++ +++ KDIDG
Sbjct: 59 SRLIKIPESISEKDLISIIEE--ESKISHGLIVQLPLPLQFDQSKILNSVPITKDIDGLS 116
Query: 437 IINIGRLCVDLPTIVPATALAVV 505
N L I PATA ++
Sbjct: 117 EKNSKNLYSGKSCIQPATARGII 139
>UniRef50_A6NP56 Cluster: Uncharacterized protein ENSP00000372121;
n=5; Eutheria|Rep: Uncharacterized protein
ENSP00000372121 - Homo sapiens (Human)
Length = 200
Score = 65.3 bits (152), Expect = 8e-10
Identities = 27/63 (42%), Positives = 46/63 (73%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
A ++ G+ LA +IK+E++Q++ +WV+ G++ P + I+VG+ ASH+YV NK AA VG
Sbjct: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGDKRPHLSMILVGESSASHSYVLNKTRAAADVG 96
Query: 251 IDA 259
I++
Sbjct: 97 INS 99
>UniRef50_A4EAK0 Cluster: Putative uncharacterized protein; n=3;
Bacteria|Rep: Putative uncharacterized protein -
Collinsella aerofaciens ATCC 25986
Length = 284
Score = 63.7 bits (148), Expect = 2e-09
Identities = 36/120 (30%), Positives = 66/120 (55%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
MA +L G +A + +EL + A G P + + VG+ +Y R ++ + V
Sbjct: 1 MAELLKGAPVARALTEELAARCAALREQGV-VPMLAIVRVGEREDDLSYERGALKRCEKV 59
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
GI+A + D+++++LL+ I+++N D +V G L+ P+P ++E V A+ P KD+D
Sbjct: 60 GIEARRVLLPVDVSQDELLAAIKDINADPAVHGCLMFRPLPAGLDEDAVAAALDPAKDVD 119
>UniRef50_Q9RW02 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Deinococcus|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Deinococcus radiodurans
Length = 299
Score = 63.3 bits (147), Expect = 3e-09
Identities = 41/152 (26%), Positives = 77/152 (50%), Gaps = 3/152 (1%)
Frame = +2
Query: 56 SASIMARILDGKALAMEIKKELKQKIAQWVSLGNR-APTIRCIIVGDDPASHTYVRNKVE 232
+AS A +L GK LA + + ++ + W L P + ++ DD AS YV++K +
Sbjct: 8 AASETAALL-GKPLADRVMRGVRADLKAWAQLDPPFEPQLVSVLASDDEASQVYVQSKAK 66
Query: 233 AAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAP 412
AK +G+ ++ + T+E L ++ L+ D +V GI+++LP+ ++ IA
Sbjct: 67 RAKKLGVAFRVVDLGAAATQEALEQTLRELSADPAVHGIVLELPLAAGLDADAALLHIAA 126
Query: 413 EKDIDGFHIINIGRLCV--DLPTIVPATALAV 502
KDI+G N+ + + ++P T +V
Sbjct: 127 RKDIEGLSPANLALIAAGREPEALLPPTPRSV 158
>UniRef50_UPI00015563B5 Cluster: PREDICTED: similar to Mthfd2-prov
protein, partial; n=1; Ornithorhynchus anatinus|Rep:
PREDICTED: similar to Mthfd2-prov protein, partial -
Ornithorhynchus anatinus
Length = 161
Score = 62.9 bits (146), Expect = 4e-09
Identities = 24/56 (42%), Positives = 43/56 (76%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAA 238
A ++ G+ LA +I++E++ ++ +WV+ GN+ P + I+VG++PASH+YV NK +AA
Sbjct: 47 AVVISGRKLARQIREEVRHEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTKAA 102
>UniRef50_P47259 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=3; Mycoplasma|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma genitalium
Length = 273
Score = 62.1 bits (144), Expect = 7e-09
Identities = 30/84 (35%), Positives = 52/84 (61%)
Frame = +2
Query: 179 IIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQ 358
I DD +S ++++ K+ A VG + I + IT+ +L+ +I +LN D +V GI++Q
Sbjct: 29 IQANDDDSSDSFIKQKLIACNTVGAKSELIKLSNQITQAELIEKIISLNHDVNVTGIILQ 88
Query: 359 LPVPDTINERRVCDAIAPEKDIDG 430
LPV +++ + +AI P KD+DG
Sbjct: 89 LPVYPHLDKNSLLEAINPLKDVDG 112
>UniRef50_A4M873 Cluster: Tetrahydrofolate
dehydrogenase/cyclohydrolase; n=1; Petrotoga mobilis
SJ95|Rep: Tetrahydrofolate dehydrogenase/cyclohydrolase
- Petrotoga mobilis SJ95
Length = 273
Score = 60.9 bits (141), Expect = 2e-08
Identities = 38/130 (29%), Positives = 66/130 (50%)
Frame = +2
Query: 116 ELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEE 295
E+K +I+ P + ++V D ++ +Y+ ++ AK GI+ L I +D+T
Sbjct: 11 EIKAEISSLKEKVPYEPKLVSLVVEPDESTKSYLNSQKRNAKKFGIN-LEIVESNDLT-- 67
Query: 296 QLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPT 475
++++ NED+ D I + P+ E + I PEKD++G + NIG + +
Sbjct: 68 ---NDLRKYNEDDDTDAIFIARPLKKGYTELDIAKYINPEKDVEGVSLHNIGSMFYEKEL 124
Query: 476 IVPATALAVV 505
VP TA AVV
Sbjct: 125 FVPCTAEAVV 134
>UniRef50_Q5RGD2 Cluster: Novel protein similar to vertebrate
formyltetrahydrofolate synthetase domain containing 1;
n=1; Danio rerio|Rep: Novel protein similar to
vertebrate formyltetrahydrofolate synthetase domain
containing 1 - Danio rerio (Zebrafish) (Brachydanio
rerio)
Length = 217
Score = 59.7 bits (138), Expect = 4e-08
Identities = 35/98 (35%), Positives = 55/98 (56%)
Frame = +2
Query: 164 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 343
PT+ I G+D NK A K +G++ + I TEE+++ E+ LN+D+ V
Sbjct: 22 PTLAIIQAGEDDG--LLEMNKKMAGK-IGLNVMQICLPHRCTEEEVIEEVLRLNKDSRVH 78
Query: 344 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 457
GI + L P T + V +AI P+KD+DG +N+GR+
Sbjct: 79 GIFLHL--PQTFLSKSVRNAIKPQKDVDGVCDLNVGRV 114
>UniRef50_Q98QV3 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=1; Mycoplasma pulmonis|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Mycoplasma pulmonis
Length = 272
Score = 56.0 bits (129), Expect = 5e-07
Identities = 39/147 (26%), Positives = 78/147 (53%), Gaps = 1/147 (0%)
Frame = +2
Query: 65 IMARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKF 244
+M ++L + + ++ + ELK+K ++ ++ +++GD+ +S YV+ K+E A+
Sbjct: 1 MMKKLLSNELVQIK-RAELKEKFSKL----DQKVKFAIVLIGDNASSKIYVKKKIEFAQD 55
Query: 245 VGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPD-TINERRVCDAIAPEKD 421
+G++A + + ++ L + + D DGI++QLPV +NE + I KD
Sbjct: 56 IGVEAKLFHFEENVDFNLLKDAFKKI--DKEYDGIILQLPVLHFDVNELLL--MIDKNKD 111
Query: 422 IDGFHIINIGRLCVDLPTIVPATALAV 502
+DG + N + I+PATA A+
Sbjct: 112 LDGLNPENEKAFYENRECIIPATARAI 138
>UniRef50_Q7NAE4 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=2; Mycoplasma gallisepticum|Rep: Bifunctional protein
folD [Includes: Methylenetetrahydrofolate dehydrogenase
(EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase
(EC 3.5.4.9)] - Mycoplasma gallisepticum
Length = 283
Score = 52.8 bits (121), Expect = 4e-06
Identities = 32/118 (27%), Positives = 57/118 (48%)
Frame = +2
Query: 80 LDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDA 259
LDG L+ ++K++L +K+ N+ I II AS YVRNK+ +GI
Sbjct: 5 LDGTKLSQKLKEDLAKKV------NNQKIKILIIISDPSEASRIYVRNKINYCDSLGIQT 58
Query: 260 LTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF 433
+ Q + E+ ++ +G+LVQLP+ + ++ ++ + I D+D F
Sbjct: 59 EVYDLSKIDDTNQFIVEMNQKISLSNPNGVLVQLPIKERLDTNKIIENIPIRLDVDAF 116
>UniRef50_UPI000023D48A Cluster: hypothetical protein FG10624.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG10624.1 - Gibberella zeae PH-1
Length = 302
Score = 52.0 bits (119), Expect = 7e-06
Identities = 30/121 (24%), Positives = 59/121 (48%)
Frame = +2
Query: 71 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
AR+L G + +I++ +K + G P + + + YV+ K A G
Sbjct: 18 ARLLTGDLVVRDIERWCDRKADK----GGVKPVMAVVYFNTGADAIDYVKIKAHVAARAG 73
Query: 251 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
+ D + Q++++++ LN++ + GIL+Q P+P +NE V +I P K+I+
Sbjct: 74 VSYWVYEMPVDASTTQVMTQVKKLNKNPRIHGILIQRPLPRQLNEPEVMRSINPIKNIEE 133
Query: 431 F 433
+
Sbjct: 134 Y 134
>UniRef50_UPI0000D9A063 Cluster: PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor; n=1; Macaca mulatta|Rep:
PREDICTED: similar to Bifunctional
methylenetetrahydrofolate dehydrogenase/cyclohydrolase,
mitochondrial precursor - Macaca mulatta
Length = 198
Score = 50.0 bits (114), Expect = 3e-05
Identities = 20/49 (40%), Positives = 35/49 (71%)
Frame = +2
Query: 344 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRLCVDLPTIVPAT 490
G LVQLP+ +ER++C+A +P+K +D F ++N+G C+D +++ AT
Sbjct: 31 GHLVQLPLAGHTDERKICNAFSPDKGVDDFPVMNVGLKCLDQYSMLLAT 79
>UniRef50_Q6X5D4 Cluster: Methylene-THF dehydrogenase; n=1;
Treponema primitia|Rep: Methylene-THF dehydrogenase -
Treponema primitia
Length = 97
Score = 49.6 bits (113), Expect = 4e-05
Identities = 30/97 (30%), Positives = 48/97 (49%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFV 247
MA++LDGK +A + + LK+ + + G PT+ I +G+ +Y + + A+ V
Sbjct: 1 MAQLLDGKVVAAALAESLKKDVEALKAKGV-TPTLGIIRLGEKGPDISYEKGATKRAEEV 59
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQ 358
G D T+E LL I+ N+D V G L Q
Sbjct: 60 GAAVKNYILPEDTTQEALLKVIKEANDDKGVHGCLAQ 96
>UniRef50_Q8ZZK1 Cluster: Bifunctional protein folD [Includes:
Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5);
Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)];
n=4; Pyrobaculum|Rep: Bifunctional protein folD
[Includes: Methylenetetrahydrofolate dehydrogenase (EC
1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC
3.5.4.9)] - Pyrobaculum aerophilum
Length = 311
Score = 48.4 bits (110), Expect = 9e-05
Identities = 36/156 (23%), Positives = 71/156 (45%), Gaps = 10/156 (6%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPAS----HTYVRNKVEA 235
M + G+ L K+ + + + +G P + +++ DDP +V K
Sbjct: 1 MVTWIRGEELHARTKEWARSHVKRLEEVGI-TPKLAVLLLNDDPVELETQRRFVTLKARD 59
Query: 236 AKFVGIDALTINRDSDITE---EQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAI 406
+ +G + S E ++ L I++LN + V G+++Q P+P ++E+ + A+
Sbjct: 60 VREIGGEVEIYELYSAPPERRTKEALRLIESLNRRDDVTGVIIQKPLPPFVDEKALFSAL 119
Query: 407 APEKDIDGFHIINIGRLCVDLP---TIVPATALAVV 505
+PEKD+D N RL D ++P T ++
Sbjct: 120 SPEKDVDALTPENKKRLLTDFDLDRDVLPCTPAGIL 155
>UniRef50_Q4S6Y9 Cluster: Chromosome 14 SCAF14723, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 14 SCAF14723, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1066
Score = 47.2 bits (107), Expect = 2e-04
Identities = 30/98 (30%), Positives = 52/98 (53%)
Frame = +2
Query: 164 PTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVD 343
P++ I G+D NK + A+ +G++ I + +E ++++E+ L+ED V
Sbjct: 23 PSLAIIQAGEDDGLLEI--NK-KMARRIGLNVTQICLAKECSEIEIVTEVLKLSEDPGVH 79
Query: 344 GILVQLPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 457
G+ + LP + RV A+ PEKD+DG +N G L
Sbjct: 80 GLYLHLPQASLTS--RVLTALKPEKDVDGLSDLNTGCL 115
>UniRef50_Q02046 Cluster: Methylenetetrahydrofolate dehydrogenase
[NAD+]; n=27; Ascomycota|Rep: Methylenetetrahydrofolate
dehydrogenase [NAD+] - Saccharomyces cerevisiae (Baker's
yeast)
Length = 320
Score = 44.0 bits (99), Expect = 0.002
Identities = 37/155 (23%), Positives = 71/155 (45%), Gaps = 11/155 (7%)
Frame = +2
Query: 74 RILDGKALAMEIKKELKQKIAQWVSLGN-RAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 250
R + +A E+ + ++ N + P + + +DPA+ Y + ++ +G
Sbjct: 6 RTILASKVAETFNTEIINNVEEYKKTHNGQGPLLVGFLANNDPAAKMYATWTQKTSESMG 65
Query: 251 IDA-LTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDID 427
L + D D EE ++ N D+SV+GI+V PV ++ + + EKD++
Sbjct: 66 FRYDLRVIEDKDFLEEAIIQA----NGDDSVNGIMVYFPVFGNAQDQYLQQVVCKEKDVE 121
Query: 428 GFHII-------NIGRLCVD--LPTIVPATALAVV 505
G + + N+ L + L +I+P T LA+V
Sbjct: 122 GLNHVYYQNLYHNVRYLDKENRLKSILPCTPLAIV 156
>UniRef50_Q54Z91 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=2; Dictyostelium discoideum|Rep:
Methylenetetrahydrofolate dehydrogenase - Dictyostelium
discoideum AX4
Length = 313
Score = 41.5 bits (93), Expect = 0.011
Identities = 31/120 (25%), Positives = 54/120 (45%)
Frame = +2
Query: 86 GKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALT 265
GK I ++++ Q ++ P + + DD + Y + A + GI+ +
Sbjct: 13 GKVDVTPIANFFREEVKQQITKNCWKPRVVAFLTSDDQGAIDYSKWTKLACQKDGIEFI- 71
Query: 266 INRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGFHIIN 445
+ R + E L+ E N D+ V GILV PV + + + D ++P KDI+G N
Sbjct: 72 LKRVERVDLEDLIIEANN---DSCVHGILVYYPVFGGMMDSYLQDVVSPTKDIEGLSTQN 128
>UniRef50_Q8KEH0 Cluster: Methylenetetrahydrofolate dehydrogenase;
n=1; Chlorobaculum tepidum|Rep:
Methylenetetrahydrofolate dehydrogenase - Chlorobium
tepidum
Length = 296
Score = 40.7 bits (91), Expect = 0.019
Identities = 25/84 (29%), Positives = 41/84 (48%)
Frame = +2
Query: 179 IIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQ 358
I+ DDPAS TY + VGI + + E + + ++ N D++V GI V
Sbjct: 33 ILASDDPASITYADYTRAGCEDVGIH-FDLRK---CEPESVRATLEAANRDSAVHGIFVY 88
Query: 359 LPVPDTINERRVCDAIAPEKDIDG 430
P+ + + D I+P KD++G
Sbjct: 89 YPIWGDKRDAELRDLISPHKDVEG 112
>UniRef50_Q8ZSG1 Cluster: Alr7549 protein; n=3; Nostocaceae|Rep:
Alr7549 protein - Anabaena sp. (strain PCC 7120)
Length = 246
Score = 38.7 bits (86), Expect = 0.075
Identities = 23/76 (30%), Positives = 36/76 (47%)
Frame = +2
Query: 200 ASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTI 379
A+ KV +GI I ++I EQ + IQ++NE++ V +VQ P+P
Sbjct: 52 AARISAEQKVATFNAIGITPNYIALSANIAVEQFDNIIQSINENSKVTAAIVQYPIPAKF 111
Query: 380 NERRVCDAIAPEKDID 427
+ P+KDID
Sbjct: 112 TSS--IQLLEPQKDID 125
>UniRef50_Q2UUX1 Cluster: RIB40 genomic DNA, SC009; n=1; Aspergillus
oryzae|Rep: RIB40 genomic DNA, SC009 - Aspergillus
oryzae
Length = 275
Score = 38.3 bits (85), Expect = 0.099
Identities = 20/93 (21%), Positives = 46/93 (49%)
Frame = +2
Query: 179 IIVGDDPASHTYVRNKVEAAKFVGIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQ 358
++ DD S+ Y + + +G+ + ++ + + + I+ +N +NSV GI+V
Sbjct: 38 VLASDDAGSNQYANWTRKTCQEIGVHFHLMK----LSPKNVATYIRAINANNSVHGIIVY 93
Query: 359 LPVPDTINERRVCDAIAPEKDIDGFHIINIGRL 457
P+ + + +AP KD++G + + R+
Sbjct: 94 YPIFGDRRDDEIRQLVAPSKDVEGLNHQTLHRI 126
>UniRef50_P11864 Cluster: Uncharacterized protein yhaC; n=7;
Enterobacteriaceae|Rep: Uncharacterized protein yhaC -
Escherichia coli (strain K12)
Length = 395
Score = 37.9 bits (84), Expect = 0.13
Identities = 39/113 (34%), Positives = 57/113 (50%), Gaps = 7/113 (6%)
Frame = +2
Query: 89 KALAMEIKKELKQKIAQWVSLGNRA-PTIRCIIVGDDPASHTYVRN----KVEAAK--FV 247
+ALA I+K LKQ + V+L N P +CII GD Y++N V + + F+
Sbjct: 33 EALAPGIEK-LKQTSIEMVTLLNTLQPGGKCIITGDFQKELAYLQNVILYNVSSLRLDFL 91
Query: 248 GIDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAI 406
G +A I R SD T E ++E N++ S I + P+ D NE R + I
Sbjct: 92 GYNAQIIQR-SDNTCELTINEPLK-NQEISTGNININCPLKDIYNEIRRLNVI 142
>UniRef50_Q8YY73 Cluster: Sensor protein; n=2; Nostocaceae|Rep:
Sensor protein - Anabaena sp. (strain PCC 7120)
Length = 1186
Score = 35.9 bits (79), Expect = 0.53
Identities = 41/167 (24%), Positives = 67/167 (40%), Gaps = 5/167 (2%)
Frame = +2
Query: 2 SSHLTSKMRSHTYIDSLGSASIMARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCI 181
+SH+ + S +DS G + A + ++ EL+Q+ ++ + AP I
Sbjct: 320 NSHIFISVNSAPILDSQGQIAAAAIVFQDVTERKHLESELQQREQEFKMVAENAPDIISR 379
Query: 182 IVGDDPASHTYVRNKVEAAKFVGIDAL--TINRDSDITEEQLLSEIQNLNED-NSVDGIL 352
I D H YV VEAA + + N + + EE +NL ++ + +
Sbjct: 380 I--DREFRHLYVSPAVEAATGIPPEEFIGKTNTELGMPEEICNFWCENLQRAFDTGEKQV 437
Query: 353 VQLPVPDTINERRVCDAIAPEKDIDGF--HIINIGRLCVDLPTIVPA 487
V+ P R I PE DG+ +IN+ R D I A
Sbjct: 438 VEFSFPTPTGLRWYQSLIVPEFASDGYATTLINVARDVTDYKQIEQA 484
>UniRef50_Q5KEZ0 Cluster: Methylenetetrahydrofolate dehydrogenase
(NAD+), putative; n=1; Filobasidiella neoformans|Rep:
Methylenetetrahydrofolate dehydrogenase (NAD+), putative
- Cryptococcus neoformans (Filobasidiella neoformans)
Length = 367
Score = 34.7 bits (76), Expect = 1.2
Identities = 28/127 (22%), Positives = 55/127 (43%), Gaps = 7/127 (5%)
Frame = +2
Query: 77 ILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGID 256
++ +A K EL +A +R P + I+ + TY +A + +GI
Sbjct: 6 LITASKVATPFKSELLSALAS-PRFSSRPPHLVGILATKKEDARTYAEFTKKACETLGIT 64
Query: 257 -ALTI------NRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPE 415
L + D + ++ I NED VDG++V P+ ++ + ++P+
Sbjct: 65 YELRLVGEAREGMDGEGVGIEVEEAILEANEDPEVDGMMVYYPIYGGRQDQYLQSVVSPQ 124
Query: 416 KDIDGFH 436
KD++G +
Sbjct: 125 KDVEGLN 131
>UniRef50_UPI000051DDF1 Cluster: ACETYLCHOLINE-BINDING PROTEIN; n=1;
Bulinus truncatus|Rep: ACETYLCHOLINE-BINDING PROTEIN -
Bulinus truncatus
Length = 203
Score = 34.3 bits (75), Expect = 1.6
Identities = 19/42 (45%), Positives = 26/42 (61%), Gaps = 3/42 (7%)
Frame = -3
Query: 456 SLPMLIMWKPSISFSGAIASQTLLS---LIVSGTGNWTRIPS 340
SLP+ MW P +SF AIA+ LLS ++VS G+ +PS
Sbjct: 74 SLPVSKMWTPDLSFYNAIAAPELLSADRVVVSKDGSVIYVPS 115
>UniRef50_A7MSZ8 Cluster: Putative uncharacterized protein; n=1;
Vibrio harveyi ATCC BAA-1116|Rep: Putative
uncharacterized protein - Vibrio harveyi ATCC BAA-1116
Length = 631
Score = 34.3 bits (75), Expect = 1.6
Identities = 22/85 (25%), Positives = 42/85 (49%), Gaps = 3/85 (3%)
Frame = +2
Query: 35 TYIDSLGSASIMARI---LDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPAS 205
TY+ LG+ + + RI +D +A A E +K+ +++ + +S GN A ++ + P
Sbjct: 201 TYLSKLGATAFIDRIDCDVDYEAPAAEWRKQALEQVKEALSSGNEAEVVQLPVGQAAPGH 260
Query: 206 HTYVRNKVEAAKFVGIDALTINRDS 280
Y++ A + +T RDS
Sbjct: 261 SAYIKQNPYTATLLTSQKIT-GRDS 284
>UniRef50_Q18E84 Cluster: ATP-dependent DNA helicase; n=1;
Haloquadratum walsbyi DSM 16790|Rep: ATP-dependent DNA
helicase - Haloquadratum walsbyi (strain DSM 16790)
Length = 2216
Score = 34.3 bits (75), Expect = 1.6
Identities = 24/78 (30%), Positives = 44/78 (56%), Gaps = 3/78 (3%)
Frame = +2
Query: 257 ALTINRDSDITEEQLLSEIQN-LNED-NSVDGILVQLPVPDTINERRVCDAIA-PEKDID 427
++TI R +++ Q ++ + LN D NSV+ ++ PV + + RVCDAI+ +DI
Sbjct: 713 SITILRTEIVSQYQNIAAAADALNIDVNSVEALITGQPVVSDVID-RVCDAISVSSEDIT 771
Query: 428 GFHIINIGRLCVDLPTIV 481
H+I ++LP ++
Sbjct: 772 IHHVIGPTGTAIELPEVL 789
>UniRef50_Q9TW65 Cluster: Dystrophin-1; n=4; root|Rep: Dystrophin-1 -
Caenorhabditis elegans
Length = 3674
Score = 34.3 bits (75), Expect = 1.6
Identities = 18/52 (34%), Positives = 27/52 (51%)
Frame = +2
Query: 74 RILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKV 229
R LD +A +KEL ++ + VSL +RA I C + G P H +K+
Sbjct: 1734 RNLDDVDIAKSTRKELAERDSHIVSLTSRATAIHCALPGKGPQLHDVTLDKL 1785
>UniRef50_UPI0000E46F89 Cluster: PREDICTED: similar to nuclear
transcription factor, X-box binding-like 1; n=2;
Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
nuclear transcription factor, X-box binding-like 1 -
Strongylocentrotus purpuratus
Length = 905
Score = 33.5 bits (73), Expect = 2.8
Identities = 23/74 (31%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Frame = -1
Query: 251 CPQILRLQLCS*HRCGSLGHR-QQLYSEWWALGFQDSPTVLFFASAPSLSP*QVLCHRGY 75
CPQ ++ + C CGS + ++ S W+ G + P VL P CHRG
Sbjct: 277 CPQTVKAK-C---HCGSQAAQLRRCSSRTWSCG-KTCPKVLLCGQHTCTQP----CHRGD 327
Query: 74 AP*CWQSPRNQCMC 33
P C + + QC+C
Sbjct: 328 CPTCPHTSQQQCLC 341
>UniRef50_A5MC89 Cluster: Putative uncharacterized protein; n=1;
Streptococcus pneumoniae SP14-BS69|Rep: Putative
uncharacterized protein - Streptococcus pneumoniae
SP14-BS69
Length = 65
Score = 33.5 bits (73), Expect = 2.8
Identities = 19/63 (30%), Positives = 34/63 (53%), Gaps = 1/63 (1%)
Frame = +2
Query: 68 MARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVG-DDPASHTYVRNKVEAAKF 244
M +I+DGKALA +++ +L +K A+ P + I+VG PA T+ + + +
Sbjct: 1 MTQIIDGKALAAKLQGQLAEKTAKLKEETALVPGLVVILVGIIQPAKSTFATRRGQLLRL 60
Query: 245 VGI 253
V +
Sbjct: 61 VPV 63
>UniRef50_Q22ST4 Cluster: Von Willebrand factor type A domain
containing protein; n=1; Tetrahymena thermophila
SB210|Rep: Von Willebrand factor type A domain
containing protein - Tetrahymena thermophila SB210
Length = 648
Score = 33.5 bits (73), Expect = 2.8
Identities = 38/151 (25%), Positives = 70/151 (46%), Gaps = 8/151 (5%)
Frame = +2
Query: 23 MRSHTYIDSLGSASIMARILDGKALAMEIKKE--LKQKIAQWVSLGNRAPTIRCIIV--- 187
++ H ++ +LG ++ ++ K+ +ME +K +K+ + + ++L + I CI+
Sbjct: 208 LKHHQHLQTLGRQTVDLVVVIDKSGSMEGEKIQLVKETLVKIINLMSSMDRI-CIVCFNE 266
Query: 188 -GDDPASHTYVRNKVEAAKFVGIDALTINRDSDITE--EQLLSEIQNLNEDNSVDGILVQ 358
GD P + T V ++ + I + ++I+E L IQN N+V IL+
Sbjct: 267 SGDRPLTFTRVTDENKQTLLNLIQQIYAGGGTNISEGINHALKAIQNRKFKNNVTSILLL 326
Query: 359 LPVPDTINERRVCDAIAPEKDIDGFHIINIG 451
DT RV I + D F+I IG
Sbjct: 327 SDGQDTKAYTRVKAYIDKYQIKDAFNIETIG 357
>UniRef50_O74539 Cluster: Peroxide stress-activated histidine kinase
mak3; n=1; Schizosaccharomyces pombe|Rep: Peroxide
stress-activated histidine kinase mak3 -
Schizosaccharomyces pombe (Fission yeast)
Length = 2344
Score = 33.5 bits (73), Expect = 2.8
Identities = 14/47 (29%), Positives = 28/47 (59%)
Frame = +2
Query: 290 EEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 430
EEQ+ ++ + +D+S++ +L+ L + D + R C IA E ++ G
Sbjct: 1438 EEQIDDDVSPVAQDSSLEELLISLDIIDLTSVMRSCQTIASEIELTG 1484
>UniRef50_Q60295 Cluster: Putative type-1 restriction enzyme MjaXP R
protein; n=1; Methanocaldococcus jannaschii|Rep:
Putative type-1 restriction enzyme MjaXP R protein -
Methanococcus jannaschii
Length = 1042
Score = 32.7 bits (71), Expect = 4.9
Identities = 16/54 (29%), Positives = 31/54 (57%), Gaps = 4/54 (7%)
Frame = +2
Query: 83 DGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGD---DPAS-HTYVRNKVE 232
DGKA+ + I +++ ++ +W++ AP I ++ G+ DP H ++R K E
Sbjct: 575 DGKAMVVTISRKVAVELYKWITKQPNAPKIAVVMSGNKSKDPEDFHPHIRTKKE 628
>UniRef50_P15028 Cluster: Iron(III) dicitrate-binding periplasmic
protein precursor; n=11; Enterobacteriaceae|Rep:
Iron(III) dicitrate-binding periplasmic protein
precursor - Escherichia coli (strain K12)
Length = 300
Score = 32.7 bits (71), Expect = 4.9
Identities = 18/47 (38%), Positives = 30/47 (63%), Gaps = 1/47 (2%)
Frame = +2
Query: 11 LTSKMRSHTYIDSLGSASIMARILDGKALAMEIKKEL-KQKIAQWVS 148
L K R+ TY ++L SA+I+ ++ GK M+ + E K+++AQW S
Sbjct: 124 LLLKSRNETYAENLQSAAIIGEMV-GKKREMQARLEQHKERMAQWAS 169
>UniRef50_A4G5B5 Cluster: Putative uncharacterized protein; n=1;
Herminiimonas arsenicoxydans|Rep: Putative
uncharacterized protein - Herminiimonas arsenicoxydans
Length = 158
Score = 32.3 bits (70), Expect = 6.5
Identities = 18/64 (28%), Positives = 35/64 (54%), Gaps = 4/64 (6%)
Frame = +2
Query: 104 EIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGIDALTIN---- 271
EIKK+ + I W++ + ++VG+ AS +V+++++ A G+ L I+
Sbjct: 40 EIKKKGDKAIEDWIADNMKGKECLVVLVGEKTASRRWVKHEIKKAWADGLAVLAIHIHNL 99
Query: 272 RDSD 283
+DSD
Sbjct: 100 KDSD 103
>UniRef50_Q8W528 Cluster: Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1; n=11; Viridiplantae|Rep:
Methylenetetrahydrofolate
dehydrogenase/methylenetetrahydrofolate cylcohydrolase
isoform 1 - Zea mays (Maize)
Length = 160
Score = 32.3 bits (70), Expect = 6.5
Identities = 14/28 (50%), Positives = 19/28 (67%), Gaps = 2/28 (7%)
Frame = +2
Query: 413 EKDIDGFHIINIGRLCVD--LPTIVPAT 490
EKD+DGFH +NIG+L + P +P T
Sbjct: 1 EKDVDGFHPLNIGKLAMKGRQPLFLPCT 28
>UniRef50_A6QZK7 Cluster: Putative uncharacterized protein; n=1;
Ajellomyces capsulatus NAm1|Rep: Putative
uncharacterized protein - Ajellomyces capsulatus NAm1
Length = 297
Score = 32.3 bits (70), Expect = 6.5
Identities = 37/149 (24%), Positives = 68/149 (45%), Gaps = 12/149 (8%)
Frame = +2
Query: 95 LAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVGI--DALTI 268
LA + + L ++ + + AP + + DPA+ Y + K T+
Sbjct: 17 LAANVARGLLAEVNEGRQTLSTAPHLVGFLANSDPAAKMYADWTEKTCKDNNFRYTLRTV 76
Query: 269 NRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDGF---HI 439
+RD DI + L++ N D VDGI+V P+ + ++ + + KD++G +I
Sbjct: 77 SRD-DIEDAILVA-----NSDPDVDGIIVYYPIFNNRQDQYLQQIVDISKDVEGLSHRYI 130
Query: 440 INIGR--LCVDLP-----TIVPATALAVV 505
N+ + +D P +I+P T LAV+
Sbjct: 131 FNMYQNIRFLDPPENKQKSILPCTPLAVI 159
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 542,694,821
Number of Sequences: 1657284
Number of extensions: 11104211
Number of successful extensions: 30263
Number of sequences better than 10.0: 125
Number of HSP's better than 10.0 without gapping: 29226
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 30211
length of database: 575,637,011
effective HSP length: 95
effective length of database: 418,195,031
effective search space used: 30528237263
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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