Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fmgV19e03f
(777 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9NR45 Cluster: Sialic acid synthase; n=39; Coelomata|R... 210 3e-53
UniRef50_Q9VG74 Cluster: CG5232-PA; n=4; Diptera|Rep: CG5232-PA ... 169 5e-41
UniRef50_UPI0000D9DE3E Cluster: PREDICTED: similar to N-acetylne... 139 6e-32
UniRef50_Q07IS3 Cluster: N-acetylneuraminate synthase; n=1; Rhod... 124 2e-27
UniRef50_A0NMM3 Cluster: N-acylneuraminate-9-phosphate synthase;... 111 2e-23
UniRef50_Q9RDX5 Cluster: N-acetylneuraminic acid condensing enzy... 107 3e-22
UniRef50_Q1IMQ8 Cluster: N-acetylneuraminate synthase; n=16; Bac... 106 5e-22
UniRef50_A4FX91 Cluster: N-acylneuraminate-9-phosphate synthase;... 105 1e-21
UniRef50_Q74B32 Cluster: Polysaccharide biosynthesis protein, pu... 105 2e-21
UniRef50_Q8A711 Cluster: Sialic acid synthase; n=1; Bacteroides ... 103 5e-21
UniRef50_A6D0F9 Cluster: Sialic acid synthase; n=2; Gammaproteob... 102 1e-20
UniRef50_A7DQW3 Cluster: N-acylneuraminate-9-phosphate synthase;... 102 1e-20
UniRef50_A6L7H8 Cluster: Sialic acid synthase; n=1; Bacteroides ... 101 3e-20
UniRef50_Q0FYM0 Cluster: N-acylneuraminate-9-phosphate synthase;... 99 1e-19
UniRef50_UPI00015B984F Cluster: UPI00015B984F related cluster; n... 97 6e-19
UniRef50_Q04TT0 Cluster: N-acetyl neuraminic (Sialic) acid synth... 95 2e-18
UniRef50_Q58465 Cluster: Uncharacterized protein MJ1065; n=1; Me... 94 3e-18
UniRef50_Q0M1E8 Cluster: N-acylneuraminate-9-phosphate synthase;... 94 4e-18
UniRef50_Q0IDR1 Cluster: N-acetylneuraminic acid condensing enzy... 90 5e-17
UniRef50_A5MZ25 Cluster: Predicted polysaccharide biosynthesis p... 89 1e-16
UniRef50_Q04TM5 Cluster: N-acetylneuraminic acid (Sialic acid) s... 89 2e-16
UniRef50_Q0A628 Cluster: N-acylneuraminate-9-phosphate synthase;... 87 5e-16
UniRef50_A3V3D1 Cluster: Polysialic acid capsule biosynthesis pr... 87 5e-16
UniRef50_A4AP54 Cluster: N-acetylneuraminate synthase; n=3; cell... 87 6e-16
UniRef50_Q3AZQ1 Cluster: N-acylneuraminate-9-phosphate synthase;... 85 1e-15
UniRef50_Q893U6 Cluster: N-acetylneuraminate synthase; n=1; Clos... 84 4e-15
UniRef50_Q89HL9 Cluster: Blr5971 protein; n=1; Bradyrhizobium ja... 82 1e-14
UniRef50_Q2Y4J1 Cluster: NeuB family member; n=5; cellular organ... 81 2e-14
UniRef50_Q9A4G6 Cluster: NeuB protein, putative; n=17; Bacteria|... 81 4e-14
UniRef50_A4B2T9 Cluster: NeuB:Antifreeze-like protein; n=1; Alte... 79 9e-14
UniRef50_Q73P39 Cluster: NeuB family protein; n=1; Treponema den... 79 1e-13
UniRef50_Q3XXA4 Cluster: N-acetylneuraminate synthase; n=1; Ente... 78 3e-13
UniRef50_A7GGU3 Cluster: NeuB family protein; n=1; Clostridium b... 78 3e-13
UniRef50_Q8DDZ7 Cluster: Sialic acid synthase; n=5; Bacteria|Rep... 77 4e-13
UniRef50_Q5R082 Cluster: Sialic acid synthase; n=47; Bacteria|Re... 77 7e-13
UniRef50_A2C5V5 Cluster: Sialic acid synthase; n=1; Prochlorococ... 74 3e-12
UniRef50_Q2N2P7 Cluster: NeuB; n=7; Proteobacteria|Rep: NeuB - A... 73 6e-12
UniRef50_Q5QWT8 Cluster: Sialic acid synthase; n=14; Bacteria|Re... 73 8e-12
UniRef50_Q1GST3 Cluster: N-acylneuraminate-9-phosphate synthase;... 73 8e-12
UniRef50_Q89HJ8 Cluster: Blr5992 protein; n=2; Proteobacteria|Re... 73 1e-11
UniRef50_Q8TJL5 Cluster: N-acetylneuraminic acid phosphate synth... 73 1e-11
UniRef50_Q7NQV6 Cluster: N-acetylneuraminic acid synthase; n=7; ... 71 4e-11
UniRef50_P39625 Cluster: Spore coat polysaccharide biosynthesis ... 71 4e-11
UniRef50_Q04TP3 Cluster: N-acetylneuraminic acid (Sialic acid) s... 70 6e-11
UniRef50_Q1PVV9 Cluster: Similarity to N-acetyl neuramic acid sy... 70 7e-11
UniRef50_Q7MPQ0 Cluster: Sialic acid synthase; n=3; Proteobacter... 69 1e-10
UniRef50_A1RHT0 Cluster: N-acylneuraminate-9-phosphate synthase;... 69 1e-10
UniRef50_Q97H26 Cluster: Sialic acid synthase; n=14; cellular or... 69 1e-10
UniRef50_Q4VKA5 Cluster: NeuNAc condensing enzyme; n=54; cellula... 69 1e-10
UniRef50_Q12JI6 Cluster: N-acetylneuraminic acid synthase-like p... 69 2e-10
UniRef50_A3PE56 Cluster: Sialic acid synthase; n=1; Prochlorococ... 68 2e-10
UniRef50_Q30V22 Cluster: N-acylneuraminate-9-phosphate synthase;... 68 3e-10
UniRef50_A4MIF1 Cluster: N-acylneuraminate-9-phosphate synthase;... 68 3e-10
UniRef50_A0LYV7 Cluster: N-acetylneuraminate synthase; n=1; Gram... 67 4e-10
UniRef50_UPI0000384B44 Cluster: COG2089: Sialic acid synthase; n... 66 9e-10
UniRef50_Q93NQ2 Cluster: NnaB; n=7; Bacteria|Rep: NnaB - Escheri... 65 2e-09
UniRef50_A3Y8V9 Cluster: NeuB family protein; n=1; Marinomonas s... 64 3e-09
UniRef50_Q7VHQ5 Cluster: Sialic acid synthase; n=6; Helicobacter... 64 5e-09
UniRef50_Q726U8 Cluster: NeuB family protein; n=2; Desulfovibrio... 64 5e-09
UniRef50_Q46675 Cluster: NeuB protein; n=8; Bacteria|Rep: NeuB p... 64 5e-09
UniRef50_A1WSD6 Cluster: N-acylneuraminate-9-phosphate synthase;... 64 5e-09
UniRef50_Q11RF6 Cluster: N-acetylneuraminic acid synthetase; n=2... 61 3e-08
UniRef50_A4U183 Cluster: N-acetylneuraminate synthase; n=1; Magn... 61 3e-08
UniRef50_A2BSE7 Cluster: Sialic acid synthase; n=1; Prochlorococ... 61 3e-08
UniRef50_A4BEM9 Cluster: Sialic acid synthase; n=1; Reinekea sp.... 58 2e-07
UniRef50_Q3B0R9 Cluster: N-acylneuraminate-9-phosphate synthase;... 58 3e-07
UniRef50_Q2BI17 Cluster: N-acetylneuraminate synthase; n=4; Bact... 57 6e-07
UniRef50_Q0P8U0 Cluster: Pse synthetase; n=14; Campylobacter|Rep... 56 7e-07
UniRef50_A6W187 Cluster: N-acylneuraminate-9-phosphate synthase;... 56 7e-07
UniRef50_A4U173 Cluster: NeuB; n=1; Magnetospirillum gryphiswald... 56 1e-06
UniRef50_Q2IZW6 Cluster: N-acetylneuraminate synthase; n=1; Rhod... 53 9e-06
UniRef50_Q0YTS4 Cluster: N-acylneuraminate-9-phosphate synthase;... 53 9e-06
UniRef50_A5W0I0 Cluster: N-acetylneuraminic acid synthase, N-ter... 51 4e-05
UniRef50_Q0AN71 Cluster: N-acetylneuraminate synthase; n=1; Mari... 50 9e-05
UniRef50_O83573 Cluster: Spore coat polysaccharide biosynthesis ... 49 1e-04
UniRef50_A0LAB4 Cluster: N-acetylneuraminic acid synthase, N-ter... 48 3e-04
UniRef50_Q2BJD7 Cluster: N-acetylneuraminic acid synthetase; n=1... 44 0.003
UniRef50_A7DQU2 Cluster: N-acylneuraminate-9-phosphate synthase;... 44 0.004
UniRef50_Q0IDQ4 Cluster: NeuB family protein; n=1; Synechococcus... 44 0.006
UniRef50_Q8EC83 Cluster: Polysaccharide biosynthesis related-pro... 38 0.28
UniRef50_UPI0000F219ED Cluster: PREDICTED: hypothetical protein;... 38 0.37
UniRef50_Q319P5 Cluster: Putative spore coat polysaccharide bios... 36 1.1
UniRef50_Q8RI47 Cluster: Tetratricopeptide repeat family protein... 34 3.4
UniRef50_A5IGD9 Cluster: Spore coat polysaccharide biosynthesis ... 34 4.6
UniRef50_Q5A950 Cluster: Sterol 3-beta-glucosyltransferase; n=2;... 34 4.6
>UniRef50_Q9NR45 Cluster: Sialic acid synthase; n=39; Coelomata|Rep:
Sialic acid synthase - Homo sapiens (Human)
Length = 359
Score = 210 bits (513), Expect = 3e-53
Identities = 98/187 (52%), Positives = 123/187 (65%)
Frame = +2
Query: 188 VEVKITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKF 367
+E+++ +GG +PCFIIAE GQNHQGD GA C KFQK+ L KF
Sbjct: 3 LELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKF 62
Query: 368 TKKYLERPYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFL 547
+K LERPY + +SWGKTYGEHK HLEFS QYREL RYA+EVGI FTAS MD ++ +FL
Sbjct: 63 NRKALERPYTSKHSWGKTYGEHKRHLEFSHDQYRELQRYAEEVGIFFTASGMDEMAVEFL 122
Query: 548 VNLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLL 727
L VPF K+GSGD+NN +L+ A K P++IS+GM +K +Y I+ + FC L
Sbjct: 123 HELNVPFFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFCFL 182
Query: 728 HCISAYP 748
C SAYP
Sbjct: 183 QCTSAYP 189
>UniRef50_Q9VG74 Cluster: CG5232-PA; n=4; Diptera|Rep: CG5232-PA -
Drosophila melanogaster (Fruit fly)
Length = 372
Score = 169 bits (412), Expect = 5e-41
Identities = 84/171 (49%), Positives = 109/171 (63%), Gaps = 1/171 (0%)
Frame = +2
Query: 239 FIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGK 418
+IIAE GQNHQG G CVKFQK+ L KFT+ L+R Y + ++WGK
Sbjct: 16 YIIAEIGQNHQGCVETAKKMIWEAKKAGCHCVKFQKSDLPAKFTRSALDREYISDHAWGK 75
Query: 419 TYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNN 598
TYGEHK +LEFS QY +L + +E+ + FTASAMD S +FL L VPFIKIGSGD+NN
Sbjct: 76 TYGEHKEYLEFSKDQYLQLQAHCKELNVDFTASAMDERSLEFLSALNVPFIKIGSGDANN 135
Query: 599 LLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQ-FCLLHCISAYP 748
LK AA+ +PL+ISTGM V+ I + K+ + L+HC+S+YP
Sbjct: 136 FPLLKKAANLNLPLVISTGMQTMQTVERIVQTMRESGKEDYALMHCVSSYP 186
>UniRef50_UPI0000D9DE3E Cluster: PREDICTED: similar to
N-acetylneuraminic acid phosphate synthase; n=1; Macaca
mulatta|Rep: PREDICTED: similar to N-acetylneuraminic
acid phosphate synthase - Macaca mulatta
Length = 274
Score = 139 bits (337), Expect = 6e-32
Identities = 65/113 (57%), Positives = 77/113 (68%)
Frame = +2
Query: 188 VEVKITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKF 367
+E+++ +GG +PCFIIAE GQNHQGD GA C KFQK+ L KF
Sbjct: 3 LELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKF 62
Query: 368 TKKYLERPYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMD 526
+K LERPY + +SWGKTYGEHK HLEF+ QYREL RYA+EVGI FTAS MD
Sbjct: 63 NRKALERPYTSKHSWGKTYGEHKRHLEFNHDQYRELQRYAEEVGIFFTASGMD 115
>UniRef50_Q07IS3 Cluster: N-acetylneuraminate synthase; n=1;
Rhodopseudomonas palustris BisA53|Rep:
N-acetylneuraminate synthase - Rhodopseudomonas
palustris (strain BisA53)
Length = 357
Score = 124 bits (300), Expect = 2e-27
Identities = 65/173 (37%), Positives = 89/173 (51%)
Frame = +2
Query: 230 NPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNS 409
NP F+IAE G NHQGD GA VK QK FT + + YD+ N+
Sbjct: 16 NPSFVIAEVGHNHQGDIEKCKAIFKAAKEAGADAVKIQKRDNRALFTAEMYDSHYDSENA 75
Query: 410 WGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGD 589
+ TYG H+ LEF+ QY EL Y +++ ILF ++A D S + L + +P KI SGD
Sbjct: 76 YAHTYGTHRECLEFNREQYLELKEYCKQLDILFFSTAFDEPSAELLEEIDMPGFKIASGD 135
Query: 590 SNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYP 748
N LK AS P+I+STG + Y+ I ++ C++ C S YP
Sbjct: 136 LVNTPLLKKVASYGKPIIVSTGGGTLADARLAYETIMPINRNLCIMQCTSGYP 188
>UniRef50_A0NMM3 Cluster: N-acylneuraminate-9-phosphate synthase;
n=1; Stappia aggregata IAM 12614|Rep:
N-acylneuraminate-9-phosphate synthase - Stappia
aggregata IAM 12614
Length = 287
Score = 111 bits (266), Expect = 2e-23
Identities = 63/171 (36%), Positives = 88/171 (51%), Gaps = 1/171 (0%)
Frame = +2
Query: 239 FIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGK 418
++IAE G NH GD G VKFQK + ++ + L RP +N +G
Sbjct: 8 YVIAEIGINHNGDIDQALEMIRKSKEAGCDAVKFQKRTVDVVYSAEELARPRENV--FGT 65
Query: 419 TYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNN 598
T G+ K LEF Y + + +E+GI + AS D S DFL++ P+IK+ S +
Sbjct: 66 TNGDLKRGLEFGKADYDRIDKLCKELGIDWFASPWDEGSVDFLLDYDTPYIKVASAMVTD 125
Query: 599 LLFLKYAASKKIPLIISTGMVDKTAVKTIYDIIS-SDHKQFCLLHCISAYP 748
FL+Y A PL++STGM D VK+ D+I S + CL HC S YP
Sbjct: 126 RDFLEYCARSGRPLLVSTGMSDMAMVKSFVDVIERSGGEIACLYHCTSTYP 176
>UniRef50_Q9RDX5 Cluster: N-acetylneuraminic acid condensing enzyme;
n=6; Bacteria|Rep: N-acetylneuraminic acid condensing
enzyme - Legionella pneumophila
Length = 338
Score = 107 bits (257), Expect = 3e-22
Identities = 69/180 (38%), Positives = 91/180 (50%), Gaps = 7/180 (3%)
Frame = +2
Query: 236 CFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERP-YDNPNS- 409
CFIIAEAG NH GD GA VKFQ T + K +E+ Y N+
Sbjct: 3 CFIIAEAGVNHNGDLQLAKELVYAAKESGADAVKFQ-TFKADTLVNKTVEKAEYQKNNAP 61
Query: 410 WGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGD 589
T E LE S+ + L A +GI F ++ D S DFL++L V +KI SG+
Sbjct: 62 ESSTQYEMLKALELSEEDHYLLSELANSLGIEFMSTGFDEQSIDFLISLGVKRLKIPSGE 121
Query: 590 SNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDII-----SSDHKQFCLLHCISAYPGA 754
N+ +L++ ASKK+PLIISTGM D V+ D + +S LLHC S YP +
Sbjct: 122 ITNVPYLQHCASKKLPLIISTGMCDLQEVRVAIDTVKPYYGNSLSDYLVLLHCTSNYPAS 181
>UniRef50_Q1IMQ8 Cluster: N-acetylneuraminate synthase; n=16;
Bacteria|Rep: N-acetylneuraminate synthase -
Acidobacteria bacterium (strain Ellin345)
Length = 300
Score = 106 bits (255), Expect = 5e-22
Identities = 59/177 (33%), Positives = 88/177 (49%)
Frame = +2
Query: 218 IGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYD 397
+G + PC++IAE G NH GD G VKFQK + +T L +P +
Sbjct: 20 VGKDQPCYVIAEIGINHNGDMDIAKRLISVAVGAGCDAVKFQKRTIDVVYTAAELAKPRE 79
Query: 398 NPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKI 577
NP +G T G+ K LEF +++E+ RY +EV + + ASA D S DF+ VP KI
Sbjct: 80 NP--FGATNGDLKRGLEFGLEEFKEIDRYCREVRMPWFASAWDEASVDFIAQFDVPCFKI 137
Query: 578 GSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYP 748
S + L++ + P+++STGM + D++ D+ LL S YP
Sbjct: 138 ASASLTDDNLLRHTRATGKPVMLSTGMSTVEQIDHAVDVLGKDN--LILLQACSTYP 192
>UniRef50_A4FX91 Cluster: N-acylneuraminate-9-phosphate synthase;
n=5; cellular organisms|Rep:
N-acylneuraminate-9-phosphate synthase - Methanococcus
maripaludis
Length = 348
Score = 105 bits (252), Expect = 1e-21
Identities = 63/178 (35%), Positives = 91/178 (51%), Gaps = 3/178 (1%)
Frame = +2
Query: 224 GNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNP 403
G FIIAEAG NH G G VKFQ T+ + Y
Sbjct: 11 GLKNAFIIAEAGVNHNGSLELAKKLIDVAFEAGVDAVKFQTFKTENVVTENAEKAEYQIQ 70
Query: 404 NSWGKTYGEHK--SHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKI 577
N+ ++ +++ LE S+ + L+ Y QE GILF ++ D S DFL +L VP KI
Sbjct: 71 NTGVESESQYEMIKKLELSEKDFERLYNYCQEKGILFLSTPFDFESADFLDDL-VPLFKI 129
Query: 578 GSGDSNNLLFLKYAASKKIPLIISTGMVDKTAV-KTIYDIISSDHKQFCLLHCISAYP 748
S D NN+ FLK+ A KK P+IISTGM + + + + ++ + + LLHC+++YP
Sbjct: 130 SSTDLNNIPFLKHIAKKKKPVIISTGMGTLCEIEEAVTALKNAGNHEIMLLHCVTSYP 187
>UniRef50_Q74B32 Cluster: Polysaccharide biosynthesis protein,
putative; n=1; Geobacter sulfurreducens|Rep:
Polysaccharide biosynthesis protein, putative -
Geobacter sulfurreducens
Length = 350
Score = 105 bits (251), Expect = 2e-21
Identities = 61/184 (33%), Positives = 91/184 (49%), Gaps = 4/184 (2%)
Frame = +2
Query: 209 DIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLER 388
++ +G NP ++IAE G NH GD GA VKFQ ++ ER
Sbjct: 8 NVPVGAENPPYVIAEIGSNHNGDMNLCRQLIDAAAEAGAHAVKFQSWTENSLIAREEYER 67
Query: 389 --PY-DNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLK 559
Y D +G K++ + + Q+RE Y +E GI F ++ D L +L
Sbjct: 68 NTEYSDKKRHFGSLRDMVKTY-QLTTDQHREAHAYCRERGIAFCSTPFSPEEADLLESLD 126
Query: 560 VPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSD-HKQFCLLHCI 736
VPF KI S D +L FLKY A K+ P+++STGM ++ + + ++ + Q LLHC+
Sbjct: 127 VPFFKIASMDIVHLPFLKYVARKRRPMLLSTGMATLAEIEAAVETVRAEGNDQVVLLHCV 186
Query: 737 SAYP 748
S YP
Sbjct: 187 SIYP 190
>UniRef50_Q8A711 Cluster: Sialic acid synthase; n=1; Bacteroides
thetaiotaomicron|Rep: Sialic acid synthase - Bacteroides
thetaiotaomicron
Length = 346
Score = 103 bits (247), Expect = 5e-21
Identities = 57/181 (31%), Positives = 85/181 (46%), Gaps = 11/181 (6%)
Frame = +2
Query: 239 FIIAEAGQNHQGDXXXXXXXXXXXX-----------XXGASCVKFQKTCLGEKFTKKYLE 385
+II E GQNH G + VK K L E+ +
Sbjct: 5 YIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMNAVKMTKRDLSEELAVSQMN 64
Query: 386 RPYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVP 565
+ YDNPNS+G+TYGEH++ LE D + E+++YA+ +G+ F + L
Sbjct: 65 QIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLDFIETLCAKGCLSLLKLFTPD 124
Query: 566 FIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAY 745
+K+ S D NL L+ A IP+I+STGM + + D+I+ H +LHC+S Y
Sbjct: 125 RLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDNALDVITRYHSNIAILHCVSQY 184
Query: 746 P 748
P
Sbjct: 185 P 185
>UniRef50_A6D0F9 Cluster: Sialic acid synthase; n=2;
Gammaproteobacteria|Rep: Sialic acid synthase - Vibrio
shilonii AK1
Length = 751
Score = 102 bits (244), Expect = 1e-20
Identities = 58/179 (32%), Positives = 83/179 (46%), Gaps = 1/179 (0%)
Frame = +2
Query: 215 RIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPY 394
+IG P FIIAE G NH G GA CVKFQ + + + +
Sbjct: 123 KIGDQEPSFIIAEIGNNHNGSLELAKELVDLAKAAGADCVKFQMRDMASMYNNEGDDD-- 180
Query: 395 DNPNSWGKTYG-EHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFI 571
D G Y + + D ++ E+F Y ++ IL + D S D L + V
Sbjct: 181 DASQDLGAQYVLDLLKRFQLCDEEFVEIFEYCKQKEILALCTPFDEASADKLEKIGVAGF 240
Query: 572 KIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYP 748
K+ S D N LKY A+KK+PLI+STGM + + + +++ + F LLHC S YP
Sbjct: 241 KVASADLTNHRLLKYLAAKKVPLILSTGMSVEQEIISAVELLEKESASFALLHCNSTYP 299
>UniRef50_A7DQW3 Cluster: N-acylneuraminate-9-phosphate synthase;
n=1; Candidatus Nitrosopumilus maritimus SCM1|Rep:
N-acylneuraminate-9-phosphate synthase - Candidatus
Nitrosopumilus maritimus SCM1
Length = 349
Score = 102 bits (244), Expect = 1e-20
Identities = 59/182 (32%), Positives = 85/182 (46%), Gaps = 1/182 (0%)
Frame = +2
Query: 215 RIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPY 394
RI P +IIAE G NH G+ GA+ VKFQK L + + + L+ P
Sbjct: 14 RISTKEPAYIIAEIGINHNGNITTAKKLIDVAVDAGANAVKFQKRSLNDIYREDVLKDP- 72
Query: 395 DNPNSWG-KTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFI 571
N S G + + + +EF D Y+EL Y +E I F + D+ S +FL +P
Sbjct: 73 -NIESQGLEILLDVLNEVEFDDDAYKELTEYCKEKHITFLCTPWDIPSVEFLEKFDLPAY 131
Query: 572 KIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYPG 751
KI S D N + PLI+STGM + ++ + + +F LLHC S YP
Sbjct: 132 KIASADMTNFPLISSLIQTGKPLIVSTGMSNMNEIEKTVSFMKEKNAKFALLHCNSTYPA 191
Query: 752 AI 757
+
Sbjct: 192 PV 193
>UniRef50_A6L7H8 Cluster: Sialic acid synthase; n=1; Bacteroides
vulgatus ATCC 8482|Rep: Sialic acid synthase -
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC
11154)
Length = 334
Score = 101 bits (241), Expect = 3e-20
Identities = 64/177 (36%), Positives = 87/177 (49%), Gaps = 4/177 (2%)
Frame = +2
Query: 230 NPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERP-YDNPN 406
N +IIAEAG NH G GA VKFQ T EK + E Y N
Sbjct: 3 NHVYIIAEAGVNHNGRLDLALQLCNAAKDAGADAVKFQ-TWKTEKIVTRNAELAVYQENN 61
Query: 407 SWGKTYGEHK--SHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIG 580
KT + K LE S + + + E+GI F ++ ++ S DFL N +PFIK+G
Sbjct: 62 ISDKTKSQFKMLKELELSYDNFEVVKNHCDEIGIQFLSTPDEIDSLDFLCNFNLPFIKLG 121
Query: 581 SGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIY-DIISSDHKQFCLLHCISAYP 748
SGD N+ FL+ S+ I +++STGM V+ Y +I + K LLHC + YP
Sbjct: 122 SGDVTNIPFLRLVGSRHIDVVLSTGMSYLGDVEIAYRTLIEAGAKSVSLLHCTTNYP 178
>UniRef50_Q0FYM0 Cluster: N-acylneuraminate-9-phosphate synthase;
n=1; Fulvimarina pelagi HTCC2506|Rep:
N-acylneuraminate-9-phosphate synthase - Fulvimarina
pelagi HTCC2506
Length = 347
Score = 98.7 bits (235), Expect = 1e-19
Identities = 61/175 (34%), Positives = 84/175 (48%), Gaps = 2/175 (1%)
Frame = +2
Query: 230 NPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNS 409
N F++AEAG NH G GA +KFQ T + Y N
Sbjct: 13 NWVFVVAEAGVNHNGSIERALDMVEAAARAGADAIKFQTFRAAGLVTANAEKAAYQKRND 72
Query: 410 WGKT-YGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSG 586
T E S LE S++Q+R + + VGI F ++ D S DFL +L V KI SG
Sbjct: 73 GIDTNQAEMLSALELSESQWRTIKDHCSMVGISFLSTPFDEDSADFLESLGVEAFKISSG 132
Query: 587 DSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDII-SSDHKQFCLLHCISAYP 748
D +L FL++ A K P+IISTGM + ++ D I ++ +LHC+S YP
Sbjct: 133 DLTHLAFLQHVARKGRPMIISTGMANLADIEEAVDAIEAAGSPPLAILHCVSDYP 187
>UniRef50_UPI00015B984F Cluster: UPI00015B984F related cluster; n=1;
unknown|Rep: UPI00015B984F UniRef100 entry - unknown
Length = 361
Score = 96.7 bits (230), Expect = 6e-19
Identities = 58/179 (32%), Positives = 84/179 (46%), Gaps = 2/179 (1%)
Frame = +2
Query: 218 IGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYD 397
IG + CF+IAEAG NH GD GA +KFQ + + Y
Sbjct: 23 IGNDGRCFVIAEAGVNHNGDVAMAHRLIDVAAAAGADAIKFQTFNAETLVDRSARKAAYQ 82
Query: 398 NPNSWGKTYG-EHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIK 574
N+ ++ E LE YR L +A + GI ++ D S DFL L VP K
Sbjct: 83 VTNTGSESSQFEMLRSLELPAQAYRALQDHAGQAGIALISTPFDEASVDFLATLGVPAYK 142
Query: 575 IGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVK-TIYDIISSDHKQFCLLHCISAYP 748
+ SGD N L+ A+K P+IISTGM + ++ + + ++ ++ C L C S+YP
Sbjct: 143 VSSGDLTNHFLLEAVAAKGKPVIISTGMANLADIEGALACLRTAGAREVCALQCTSSYP 201
>UniRef50_Q04TT0 Cluster: N-acetyl neuraminic (Sialic) acid
synthetase; n=4; Leptospira|Rep: N-acetyl neuraminic
(Sialic) acid synthetase - Leptospira borgpetersenii
serovar Hardjo-bovis (strain JB197)
Length = 332
Score = 95.1 bits (226), Expect = 2e-18
Identities = 56/184 (30%), Positives = 91/184 (49%), Gaps = 1/184 (0%)
Frame = +2
Query: 200 ITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKY 379
I ++ +G +P ++AE G NH D GA VKFQ T+++
Sbjct: 9 IASELYVGSESPPIVVAEIGLNHNNDEEIGKKTIAAAKKAGAQVVKFQSYV-----TEEF 63
Query: 380 LERPYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLK 559
++ NP++ K + E S+T +R+ + A++ G+ F ++ + + S L++LK
Sbjct: 64 ID--VHNPDA--KILVDIFKKYELSETMHRKFQKTAEDEGLFFFSTPLCVNSLHLLLSLK 119
Query: 560 VPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSD-HKQFCLLHCI 736
VP IKI SGD N L A K+P+I+S+G D V + + + CLLHC+
Sbjct: 120 VPAIKIASGDITNKTLLLETAKSKLPVILSSGAADFFEVNRAISFLEKEGTDKLCLLHCV 179
Query: 737 SAYP 748
S YP
Sbjct: 180 SLYP 183
>UniRef50_Q58465 Cluster: Uncharacterized protein MJ1065; n=1;
Methanocaldococcus jannaschii|Rep: Uncharacterized
protein MJ1065 - Methanococcus jannaschii
Length = 337
Score = 94.3 bits (224), Expect = 3e-18
Identities = 62/189 (32%), Positives = 90/189 (47%), Gaps = 1/189 (0%)
Frame = +2
Query: 185 MVEVKITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEK 364
M ++KI D +G P FIIAE G NH GD GA +KFQ +
Sbjct: 1 MEKIKIGDRY-VGKGEPTFIIAEGGLNHNGDIDIGKELVKEAKKCGADAIKFQSYHTEDF 59
Query: 365 FTKKYLERPYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDF 544
+KK Y E LE S+ ++ EL YA+++GI+F ++ +D+ D
Sbjct: 60 ISKK-------------SEYYELFKSLELSEEEFYELKEYAEKIGIMFISTPLDLKYVDI 106
Query: 545 LVNLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDH-KQFC 721
L + VP KI SGD L+ A P+I+STGM D + ++ ++ +
Sbjct: 107 LNKMNVPAFKIASGDLTFYPLLEKVAKTGKPVILSTGMSDIGEIWEAVKVLENNGCRDII 166
Query: 722 LLHCISAYP 748
LLHCIS+YP
Sbjct: 167 LLHCISSYP 175
>UniRef50_Q0M1E8 Cluster: N-acylneuraminate-9-phosphate synthase;
n=2; Bacteria|Rep: N-acylneuraminate-9-phosphate
synthase - Caulobacter sp. K31
Length = 310
Score = 93.9 bits (223), Expect = 4e-18
Identities = 54/170 (31%), Positives = 81/170 (47%)
Frame = +2
Query: 239 FIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGK 418
F+IAE G NH GD G VKFQK + +T + L +P +P WG
Sbjct: 34 FVIAEIGINHNGDLEITKQLIRAARDAGCDAVKFQKRTIDIVYTPEVLAQPRQSP--WGD 91
Query: 419 TYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNN 598
T K LEF +Y + Y +E+G+ + ASA D+ S FL +P+ KI S +
Sbjct: 92 TQRAQKEGLEFGKAEYDVIDAYCRELGLAWFASAWDVPSQTFLAAYDLPYNKIASAMLTH 151
Query: 599 LLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYP 748
++ A++ + STGM + T +I+ + F L+H +S YP
Sbjct: 152 RPLIEAVAAEGKLVFASTGMCTFEQIDTAVEILRAAACPFVLMHTVSTYP 201
>UniRef50_Q0IDR1 Cluster: N-acetylneuraminic acid condensing enzyme;
n=1; Synechococcus sp. CC9311|Rep: N-acetylneuraminic
acid condensing enzyme - Synechococcus sp. (strain
CC9311)
Length = 347
Score = 90.2 bits (214), Expect = 5e-17
Identities = 56/183 (30%), Positives = 82/183 (44%), Gaps = 2/183 (1%)
Frame = +2
Query: 215 RIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPY 394
RI +P +I+AE G NH G+ GA VKFQ E + Y
Sbjct: 11 RISSIDPTYIVAEIGVNHNGNISLAHKLIDSAKDAGADAVKFQTYVTDELVIRNTRTAKY 70
Query: 395 DNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIK 574
N+ E S + EL+R+ GI F ++ D VS F+ NLK IK
Sbjct: 71 QKENALFDDQYTMLEKYELSFESFHELYRHCAAAGIDFLSTPFDPVSLRFIANLKPVAIK 130
Query: 575 IGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIIS--SDHKQFCLLHCISAYP 748
SG+ N + L AA ++P+I+STGM + + + D I+ + +L C+S YP
Sbjct: 131 WASGELTNKMLLDQAAKTRLPIILSTGM---SRINDVDDAITWIGRNTPLVVLQCVSNYP 187
Query: 749 GAI 757
A+
Sbjct: 188 AAM 190
>UniRef50_A5MZ25 Cluster: Predicted polysaccharide biosynthesis
protein; n=1; Clostridium kluyveri DSM 555|Rep:
Predicted polysaccharide biosynthesis protein -
Clostridium kluyveri DSM 555
Length = 335
Score = 89.0 bits (211), Expect = 1e-16
Identities = 59/189 (31%), Positives = 89/189 (47%), Gaps = 1/189 (0%)
Frame = +2
Query: 185 MVEVKITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEK 364
M ++KI + I IG +PCFIIAEAG NH GD GA+ VKFQ +
Sbjct: 1 MNDIKIGNKI-IGNTHPCFIIAEAGSNHNGDIKQAKELVDIAVEAGANAVKFQTFTADKL 59
Query: 365 FTKKYLERPYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDF 544
F+K + N K + EF ++E+ Y + GI+F + + D
Sbjct: 60 FSKNH------PANKIVKNF-------EFKLEWHKEMKEYCDKKGIMFITTPFQKDAVDL 106
Query: 545 LVNLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDH-KQFC 721
L L + KI SGD + L Y ++ P+I+++GM VK ++ I + +
Sbjct: 107 LEKLNIEGYKIASGDMDYYPLLDYISNTGKPIILASGMAYMDEVKEAFNRIKNGKTEDIA 166
Query: 722 LLHCISAYP 748
+LHC+S YP
Sbjct: 167 ILHCVSNYP 175
>UniRef50_Q04TM5 Cluster: N-acetylneuraminic acid (Sialic acid)
synthetase; n=2; Leptospira borgpetersenii serovar
Hardjo-bovis|Rep: N-acetylneuraminic acid (Sialic acid)
synthetase - Leptospira borgpetersenii serovar
Hardjo-bovis (strain JB197)
Length = 282
Score = 88.6 bits (210), Expect = 2e-16
Identities = 57/180 (31%), Positives = 84/180 (46%)
Frame = +2
Query: 209 DIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLER 388
+I+IGGNNP FIIAEAG NH GD A+ +KFQ E+F +
Sbjct: 9 NIKIGGNNPVFIIAEAGLNHGGDLNLALRMIDEAADAKANAIKFQAYNSEERFGENKEAV 68
Query: 389 PYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPF 568
P +GK ++ L +Q+ ILF A+ D+ + + L + V
Sbjct: 69 NLVKPAEFGK-------------KEFLLLKERSQKKNILFFATPFDVPNLNMLKEIGVEI 115
Query: 569 IKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYP 748
+KI S D N+ L+ AA + +I+S G + ++T I F LLHC+S+YP
Sbjct: 116 LKIASCDICNITLLEAAADSGLIVILSRGTASASEIETAVSIFKKKKSPFILLHCVSSYP 175
>UniRef50_Q0A628 Cluster: N-acylneuraminate-9-phosphate synthase;
n=1; Alkalilimnicola ehrlichei MLHE-1|Rep:
N-acylneuraminate-9-phosphate synthase - Alkalilimnicola
ehrlichei (strain MLHE-1)
Length = 348
Score = 87.0 bits (206), Expect = 5e-16
Identities = 57/188 (30%), Positives = 85/188 (45%)
Frame = +2
Query: 185 MVEVKITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEK 364
M E+ I D IG N+P ++IAEAG +H GA +KFQ E
Sbjct: 1 MTELHI-DGRAIGPNHPPYVIAEAGVHHYDSLELARAYVLEARKAGADAIKFQTYTADEL 59
Query: 365 FTKKYLERPYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDF 544
T+ Y + + + S T+YR LF YA+E+GI ++ D S D
Sbjct: 60 VTR--WAPLYWTDARFETQHQVFSTKRGLSPTEYRSLFDYARELGITPLSTPFDPASVDL 117
Query: 545 LVNLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCL 724
L L + K+ S D + L+ A K P+++STG V++ +++ S+ L
Sbjct: 118 LDGLGMAAFKVASADITHRPLLQDIAGKGKPVLLSTGAASMAEVRSALEVLESEGVPVAL 177
Query: 725 LHCISAYP 748
LHC AYP
Sbjct: 178 LHCSLAYP 185
>UniRef50_A3V3D1 Cluster: Polysialic acid capsule biosynthesis
protein SiaC; n=3; Bacteria|Rep: Polysialic acid capsule
biosynthesis protein SiaC - Loktanella vestfoldensis
SKA53
Length = 343
Score = 87.0 bits (206), Expect = 5e-16
Identities = 52/178 (29%), Positives = 86/178 (48%)
Frame = +2
Query: 215 RIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPY 394
+IG +P +IAE G NH GD G VK Q + ++ T++ R
Sbjct: 7 KIGPEHPPLVIAEIGINHGGDLAVAKEMVRLAALSGCEMVKHQTHIIADEMTEE--ARQI 64
Query: 395 DNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIK 574
PN+ + E S + EL RY + +G+++ ++ + DFL +L VP K
Sbjct: 65 FPPNA-DVSIWEVMEACALSLDEEAELKRYTESLGMIWISTPFSRAAADFLQDLDVPAFK 123
Query: 575 IGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYP 748
IGSG+++NL +++ A P+I+STGM +++ I+ + LL C + YP
Sbjct: 124 IGSGEADNLPLIRHIARMGKPVIMSTGMQSIESIRASVAILDGAGVDYALLECTNLYP 181
>UniRef50_A4AP54 Cluster: N-acetylneuraminate synthase; n=3;
cellular organisms|Rep: N-acetylneuraminate synthase -
Flavobacteriales bacterium HTCC2170
Length = 351
Score = 86.6 bits (205), Expect = 6e-16
Identities = 59/190 (31%), Positives = 82/190 (43%), Gaps = 2/190 (1%)
Frame = +2
Query: 185 MVEVKITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEK 364
M +KI +D I +PCFIIAEAG NH G G CVKFQ
Sbjct: 1 MKSIKI-EDFLISKESPCFIIAEAGVNHNGKLEMALELVRKAKEIGVDCVKFQTFTAESV 59
Query: 365 FTKKYLERPYD-NPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFD 541
TKK + Y ++ E LE S Y ++ + I F ++ + D
Sbjct: 60 ITKKAPKANYQLEVTDPAESQFEMLKKLELSGDDYIKIIEECNKQNITFLSTPYNEEDAD 119
Query: 542 FLVNLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAV-KTIYDIISSDHKQF 718
FL L V KI SG L FL++ A P+I+S+GM V + + I + + Q
Sbjct: 120 FLNKLGVSAFKIASGQIVELAFLEHVAKFGKPIILSSGMATLAEVYEAVMTIREAGNNQM 179
Query: 719 CLLHCISAYP 748
+L C + YP
Sbjct: 180 AILQCTTNYP 189
>UniRef50_Q3AZQ1 Cluster: N-acylneuraminate-9-phosphate synthase;
n=17; Bacteria|Rep: N-acylneuraminate-9-phosphate
synthase - Synechococcus sp. (strain CC9902)
Length = 762
Score = 85.4 bits (202), Expect = 1e-15
Identities = 53/179 (29%), Positives = 80/179 (44%), Gaps = 2/179 (1%)
Frame = +2
Query: 218 IGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYD 397
IG +PCF+IAE G NH GD GA C KFQ +G+ ++ + D
Sbjct: 128 IGAEHPCFVIAEIGNNHNGDINTALQLIDAAHAAGADCAKFQMRDMGQLYSNS--GKSSD 185
Query: 398 NPNSWGKTYG-EHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIK 574
+ G Y + + SD + F Y+ G++ + D S L + K
Sbjct: 186 MASDLGTQYTLDLLERFQLSDDELFHCFDYSASKGLVPLCTPWDQTSLQKLNQWGMEGFK 245
Query: 575 IGSGD-SNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYP 748
+ S D +N+ L + AA+ K PLI STGM + +++ + + LLHC S YP
Sbjct: 246 VASADFTNHALITQLAATGK-PLICSTGMASELEIRSGIRHLQKAGANYVLLHCNSTYP 303
>UniRef50_Q893U6 Cluster: N-acetylneuraminate synthase; n=1;
Clostridium tetani|Rep: N-acetylneuraminate synthase -
Clostridium tetani
Length = 351
Score = 83.8 bits (198), Expect = 4e-15
Identities = 54/189 (28%), Positives = 86/189 (45%), Gaps = 8/189 (4%)
Frame = +2
Query: 215 RIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPY 394
+IG N P +I+AE G NH GD G VKFQ +T K L
Sbjct: 11 KIGENYPAYIVAEIGANHNGDVNLAKRMIEVAAECGVDAVKFQT------YTAKELVSDT 64
Query: 395 DNPNSWG-------KTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVN 553
D +WG +T G+ + ++E+F YA ++G++ ++ + +FL
Sbjct: 65 DRILTWGPCGKQKTETIGKMFDRIALPREAHKEVFEYANKLGLMAFSTPFSIKGVEFLNE 124
Query: 554 LKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVD-KTAVKTIYDIISSDHKQFCLLH 730
L+VP K+ + D + L LK K P+++S G A I +I S ++ ++H
Sbjct: 125 LEVPCFKVAASDVDYLDILKEIGKTKKPVMLSLGKCTLGEADLAIETLIESGCEKIVIMH 184
Query: 731 CISAYPGAI 757
C+S YP I
Sbjct: 185 CVSQYPSPI 193
>UniRef50_Q89HL9 Cluster: Blr5971 protein; n=1; Bradyrhizobium
japonicum|Rep: Blr5971 protein - Bradyrhizobium
japonicum
Length = 641
Score = 82.2 bits (194), Expect = 1e-14
Identities = 52/180 (28%), Positives = 73/180 (40%)
Frame = +2
Query: 218 IGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYD 397
+G PC++IAE G NH GD GA C KFQ L E + L D
Sbjct: 19 LGDGEPCYVIAEVGNNHNGDFDRAIALVDAAVAAGADCAKFQMRKLDEVYRASSLSGK-D 77
Query: 398 NPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKI 577
+ + T + E + Q +++ Y GI + + D S L V K+
Sbjct: 78 DDLAVEYTL-DLLRRFELTTEQQKKIADYCASKGIQYLCTPWDAKSVAVLEGFGVQAYKV 136
Query: 578 GSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYPGAI 757
S D NL L + LI+STGM +K + + + LLHC S YP A+
Sbjct: 137 ASADLTNLPLLARLIATGKTLIVSTGMSTTEEIKAAAEFLDERKAGYVLLHCQSTYPAAL 196
>UniRef50_Q2Y4J1 Cluster: NeuB family member; n=5; cellular
organisms|Rep: NeuB family member - uncultured archaeon
Length = 360
Score = 81.4 bits (192), Expect = 2e-14
Identities = 58/180 (32%), Positives = 85/180 (47%), Gaps = 10/180 (5%)
Frame = +2
Query: 239 FIIAEAGQNH-----QGDXX---XXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPY 394
FI+AEAG N+ +G+ GA +KFQ T E+ KY +
Sbjct: 19 FIVAEAGVNYYDIAKKGNIEPLEAAKLMIEKAADSGADAIKFQ-TYKAERIASKYSPAYW 77
Query: 395 DNPNSWGKT-YGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFI 571
D K+ Y K +F + +Y+EL YA ILF ++ D + DFL L +P
Sbjct: 78 DVTKENTKSQYELFKKFDKFGEDEYKELAGYAANTDILFMSTPFDNEAVDFLDKL-MPVF 136
Query: 572 KIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSD-HKQFCLLHCISAYP 748
KI S D N+ F+ Y A K+ P+ +STG +K + I S+ + + +LHCI YP
Sbjct: 137 KISSSDITNIPFISYVARKRKPIFLSTGASTIEEIKEAVNAIESEGNDKIVILHCILNYP 196
>UniRef50_Q9A4G6 Cluster: NeuB protein, putative; n=17;
Bacteria|Rep: NeuB protein, putative - Caulobacter
crescentus (Caulobacter vibrioides)
Length = 356
Score = 80.6 bits (190), Expect = 4e-14
Identities = 57/184 (30%), Positives = 90/184 (48%), Gaps = 6/184 (3%)
Frame = +2
Query: 215 RIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPY 394
+IG ++ ++I E NH G G +K Q T + T ++RP
Sbjct: 18 KIGADHSPYVICELSGNHNGSLERCLAMVDAAADTGCDAIKIQ-TYTADTITLD-VDRPE 75
Query: 395 DNPNS--W-GKTYGE--HKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLK 559
+ W G+T E ++H F + +F A++ G+ +S D + D L +L
Sbjct: 76 FKIHGGLWDGRTLYELYEEAHTPFE--WHAAIFERARQRGVTIFSSPFDETAVDLLDSLG 133
Query: 560 VPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYD-IISSDHKQFCLLHCI 736
P KI S ++ +L +KYAA+K PLIISTGM + T ++T D +S+ LLHC+
Sbjct: 134 APAFKIASFEAVDLPLIKYAAAKGKPLIISTGMANLTEMQTALDTALSAGAPGVLLLHCV 193
Query: 737 SAYP 748
S+YP
Sbjct: 194 SSYP 197
>UniRef50_A4B2T9 Cluster: NeuB:Antifreeze-like protein; n=1;
Alteromonas macleodii 'Deep ecotype'|Rep:
NeuB:Antifreeze-like protein - Alteromonas macleodii
'Deep ecotype'
Length = 347
Score = 79.4 bits (187), Expect = 9e-14
Identities = 52/184 (28%), Positives = 85/184 (46%), Gaps = 3/184 (1%)
Frame = +2
Query: 206 DDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLE 385
D I + +IIAE NH GD G S +K Q T + T L+
Sbjct: 4 DQTNINEAHKPYIIAELSANHGGDLSRAKESITKAAEVGVSAIKIQ-TYTPDTMTLDSLQ 62
Query: 386 RPYDNPNS-W-GKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLK 559
+ + W G++ E + + ELF +A+ G+ ++ D + D L +L
Sbjct: 63 DDFIVKDGLWAGRSLYELYTEAYTPYEWHEELFNHAKNCGVTIFSTPFDETAVDLLESLN 122
Query: 560 VPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAV-KTIYDIISSDHKQFCLLHCI 736
P KI S + +L +KY ASK P+++STGM +T + + + + ++ + L HCI
Sbjct: 123 TPAYKIASFEIVDLPLVKYIASKNKPILMSTGMASQTEIEEAVTSVRANGDCELLLFHCI 182
Query: 737 SAYP 748
S+YP
Sbjct: 183 SSYP 186
>UniRef50_Q73P39 Cluster: NeuB family protein; n=1; Treponema
denticola|Rep: NeuB family protein - Treponema denticola
Length = 379
Score = 79.0 bits (186), Expect = 1e-13
Identities = 58/175 (33%), Positives = 79/175 (45%), Gaps = 2/175 (1%)
Frame = +2
Query: 230 NPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNS 409
NP IAE G +H G GA VKFQ E D P
Sbjct: 19 NP-LTIAEIGTSHNGSIQKARNLIDVAAEAGAKAVKFQIVYADEILHPN--TGYVDLPTG 75
Query: 410 WGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGD 589
Y KS LE + Y+EL Y++ +LF+AS S + L LK FIKI S +
Sbjct: 76 KIPLYDRFKS-LELPVSFYKELAEYSRSKKLLFSASPFGFRSAEELAALKPDFIKIASPE 134
Query: 590 SNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQ--FCLLHCISAYP 748
N + LKY A IP+I+S+G+ ++ + S++K LLHCI++YP
Sbjct: 135 LNYVQLLKYCAGFNIPMILSSGVSILKDIEKAVSFLRSENKDLPLALLHCITSYP 189
>UniRef50_Q3XXA4 Cluster: N-acetylneuraminate synthase; n=1;
Enterococcus faecium DO|Rep: N-acetylneuraminate
synthase - Enterococcus faecium DO
Length = 335
Score = 77.8 bits (183), Expect = 3e-13
Identities = 54/173 (31%), Positives = 74/173 (42%), Gaps = 1/173 (0%)
Frame = +2
Query: 239 FIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPN-SWG 415
++IAE G NH G GA+ VKFQ + +KK Y N
Sbjct: 7 YVIAEIGVNHNGSLDLALESIDKAKECGANAVKFQTFKTNKLVSKKAPMAKYQKDNLKED 66
Query: 416 KTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSN 595
+ E LE S + + + Y + I F ++ D S DFL + V KIGSGD
Sbjct: 67 SSQFEMLKKLELSQSDFIRIKDYCIQNKIDFLSTPFDEESADFLKQIGVQGFKIGSGDLT 126
Query: 596 NLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYPGA 754
NL FL+ +P+++STGM D V D +LHC S YP +
Sbjct: 127 NLPFLRKIDMYGLPVLLSTGMADIHEVSEAVDCFID--SPVTILHCTSNYPAS 177
>UniRef50_A7GGU3 Cluster: NeuB family protein; n=1; Clostridium
botulinum F str. Langeland|Rep: NeuB family protein -
Clostridium botulinum (strain Langeland / NCTC 10281 /
Type F)
Length = 343
Score = 77.8 bits (183), Expect = 3e-13
Identities = 55/179 (30%), Positives = 81/179 (45%), Gaps = 1/179 (0%)
Frame = +2
Query: 215 RIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPY 394
++G + FIIAE G NH G+ GA VKFQ + +K Y
Sbjct: 10 KVGEKSSIFIIAEIGVNHNGNIDLAYKLIDLASKAGADAVKFQMF-----YPEKLCSEIY 64
Query: 395 DNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIK 574
K E S ++L Y +G+ F + D S D ++NL IK
Sbjct: 65 R------KDEIEMLKKYVLSFENMKKLRDYTYSLGLEFIVTPFDFKSLDDIINLDCSAIK 118
Query: 575 IGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAV-KTIYDIISSDHKQFCLLHCISAYP 748
+ SG+ ++ F+K AAS PLIISTG + + V + + I S ++ +LHC+S YP
Sbjct: 119 VASGELTHIPFIKKAASYNKPLIISTGASNLSDVERAVIAIKSVADEKISILHCVSTYP 177
>UniRef50_Q8DDZ7 Cluster: Sialic acid synthase; n=5; Bacteria|Rep:
Sialic acid synthase - Vibrio vulnificus
Length = 333
Score = 77.4 bits (182), Expect = 4e-13
Identities = 66/182 (36%), Positives = 84/182 (46%), Gaps = 7/182 (3%)
Frame = +2
Query: 230 NPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQ--KTCLGEKFTKKYLERPYDNP 403
N FIIAEAG NH GD G VKFQ KT L K E +N
Sbjct: 3 NKTFIIAEAGVNHNGDIRLAKQLIDAAADAGVDAVKFQTWKTELLVTEDAKMAEYQVENT 62
Query: 404 NSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGS 583
+T E LE S + EL Y + GI F ++ + S FL L+ F KIGS
Sbjct: 63 QR-EETQFEMLKRLELSYDDFTELKSYCDDKGITFMSTPDEEQSATFLDGLQAVF-KIGS 120
Query: 584 GDSNNLLFLKYAASKKIPLIISTGM----VDKTAVKTIYDI-ISSDHKQFCLLHCISAYP 748
G+ N FL++ AS P+I+STGM + AV T+ D +S D +LH + YP
Sbjct: 121 GELTNTPFLRHIASFAKPVILSTGMGYLSEVEHAVVTLRDAGLSLD--MITVLHATTDYP 178
Query: 749 GA 754
A
Sbjct: 179 TA 180
>UniRef50_Q5R082 Cluster: Sialic acid synthase; n=47; Bacteria|Rep:
Sialic acid synthase - Idiomarina loihiensis
Length = 352
Score = 76.6 bits (180), Expect = 7e-13
Identities = 47/177 (26%), Positives = 78/177 (44%)
Frame = +2
Query: 218 IGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYD 397
IG ++ ++AE G NH+G GA +K Q + ++ + +
Sbjct: 18 IGYDHDPVVVAEIGINHEGSLETAYEMVDAAVSAGAEIIKHQTHVVEDEMSA---DAKKV 74
Query: 398 NPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKI 577
P + + E ++ +L Y + G +F ++ + + L + V KI
Sbjct: 75 IPGNADVSIYEIMERCALNEEDETKLKEYVESKGAIFISTPFSRAAAERLERMGVEAYKI 134
Query: 578 GSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYP 748
GSG+ NN L+ AS K P+I+STGM D ++ DI Q+ LLHC + YP
Sbjct: 135 GSGECNNYPLLELVASYKKPIILSTGMNDIPSIAKAVDIFRKHGVQYALLHCTNVYP 191
>UniRef50_A2C5V5 Cluster: Sialic acid synthase; n=1; Prochlorococcus
marinus str. MIT 9303|Rep: Sialic acid synthase -
Prochlorococcus marinus (strain MIT 9303)
Length = 335
Score = 74.1 bits (174), Expect = 3e-12
Identities = 51/176 (28%), Positives = 80/176 (45%), Gaps = 7/176 (3%)
Frame = +2
Query: 242 IIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGKT 421
IIAEAG NH G+ GA +KFQ E + + Y + T
Sbjct: 5 IIAEAGVNHNGEIQNAYRLIDSAKFAGADAIKFQSFSSIELTAENAPKAKYQQMYADRST 64
Query: 422 YGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNNL 601
E + LE ++ +++ + Y +++ I F ++A D L+ LKV IK+ SG+ +
Sbjct: 65 QREMLARLELNEMEHQLIADYCEKIEIEFLSTAFGQSQLDLLIKLKVQAIKVASGEITHW 124
Query: 602 LFLKYAASK----KIPLIISTGMVDKTAVKTIYDI-ISSDHK--QFCLLHCISAYP 748
LK A K + + +STGM + ++ DI I D + +LHC S YP
Sbjct: 125 PLLKEMAKKAYENNLDVYLSTGMSEIKEIQDALDIFIKEDISLGKIFILHCTSHYP 180
>UniRef50_Q2N2P7 Cluster: NeuB; n=7; Proteobacteria|Rep: NeuB -
Aeromonas hydrophila
Length = 345
Score = 73.3 bits (172), Expect = 6e-12
Identities = 55/183 (30%), Positives = 85/183 (46%), Gaps = 6/183 (3%)
Frame = +2
Query: 218 IGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYD 397
IG ++IAE NH G+ GAS VK Q T + T K +RP
Sbjct: 8 IGPAQAPYVIAELSANHNGNLERALAIMTAAKAAGASAVKLQ-TYRPDTITLKS-DRPEF 65
Query: 398 NPNSWGKTYGEHKSH--LEFSDTQY---RELFRYAQEVGILFTASAMDMVSFDFLVNLKV 562
+ G + H + E++ T + + LF +E+G+ +S D + D L +L
Sbjct: 66 QIH--GGLWDGHSLYDLYEWAHTPWEWHQALFAKGRELGLTVFSSPFDFSAVDLLESLDC 123
Query: 563 PFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDI-ISSDHKQFCLLHCIS 739
P KI S + +L ++YAA PLI+STGM ++ + ++ + Q LLHC+S
Sbjct: 124 PAYKIASFELVDLPLIRYAAQTGKPLIMSTGMANEAEIAAAVEMALKHGSGQLALLHCVS 183
Query: 740 AYP 748
YP
Sbjct: 184 GYP 186
>UniRef50_Q5QWT8 Cluster: Sialic acid synthase; n=14; Bacteria|Rep:
Sialic acid synthase - Idiomarina loihiensis
Length = 357
Score = 72.9 bits (171), Expect = 8e-12
Identities = 54/157 (34%), Positives = 76/157 (48%), Gaps = 4/157 (2%)
Frame = +2
Query: 242 IIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGKT 421
IIAEAG NH GD GA VKFQ T+K + Y N G+
Sbjct: 4 IIAEAGVNHNGDAKLARDLVTSAHKAGADIVKFQTFKAKNIVTEKATQANYQKKN-LGRE 62
Query: 422 YGE--HKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVN-LKVPFIKIGSGDS 592
+ LE S + EL Y E+GI F ++A D S +FLVN L + +K+ SG+
Sbjct: 63 ESQLAMLQRLELSHELHYELVDYCNELGIEFLSTAFDDESLNFLVNDLGLKRLKLPSGEI 122
Query: 593 NNL-LFLKYAASKKIPLIISTGMVDKTAVKTIYDIIS 700
N L LK+A + LI+STGM ++++ +I+
Sbjct: 123 TNAPLVLKHAQT-GCDLIVSTGMATMAEIESVLGVIA 158
>UniRef50_Q1GST3 Cluster: N-acylneuraminate-9-phosphate synthase;
n=2; Alphaproteobacteria|Rep:
N-acylneuraminate-9-phosphate synthase - Sphingopyxis
alaskensis (Sphingomonas alaskensis)
Length = 350
Score = 72.9 bits (171), Expect = 8e-12
Identities = 54/179 (30%), Positives = 71/179 (39%), Gaps = 9/179 (5%)
Frame = +2
Query: 239 FIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGK 418
F+IAEAG NH G GA VKFQ E T + Y +
Sbjct: 12 FVIAEAGVNHDGSLDKALRLVDIAVEAGADAVKFQTFRTDEVVTPDAAKAAYQQRQTGAG 71
Query: 419 TYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNN 598
T E LE D + L R+ E GI F ++ + D L+ L + IKI SG+ N
Sbjct: 72 TQYEMIRALELDDAAHERLARHCAERGIEFMSTPFAPWAVDMLLGLGMRRIKIASGEIVN 131
Query: 599 LLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHK---------QFCLLHCISAYP 748
+ A P+I+STGM + V D I + +LHC S YP
Sbjct: 132 KPLIDKVAGSGRPIILSTGMAEMAEVVRAVDWIRTAQSAAGIAMSPGDLVVLHCTSEYP 190
>UniRef50_Q89HJ8 Cluster: Blr5992 protein; n=2; Proteobacteria|Rep:
Blr5992 protein - Bradyrhizobium japonicum
Length = 356
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/163 (33%), Positives = 70/163 (42%), Gaps = 5/163 (3%)
Frame = +2
Query: 242 IIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQ----KTCLGEKFTKK-YLERPYDNPN 406
IIAEAG NH G GA VKFQ K G K Y +R D
Sbjct: 7 IIAEAGVNHDGSLEKALALVDAAADAGADIVKFQTFNAKALAGGAAKKADYQQRTTDAAE 66
Query: 407 SWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSG 586
S LE + L A E GI F ++ D S FL++LK+P IKIGSG
Sbjct: 67 SQLAML----ERLELPQAAHHTLIERAAERGIEFLSTPFDDASLGFLLSLKLPRIKIGSG 122
Query: 587 DSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQ 715
D N L AA LI+STGM + ++ +++ + Q
Sbjct: 123 DLTNAPLLHAAARAGATLILSTGMATLSEIEEALGVLAHGYAQ 165
>UniRef50_Q8TJL5 Cluster: N-acetylneuraminic acid phosphate
synthase; n=11; cellular organisms|Rep:
N-acetylneuraminic acid phosphate synthase -
Methanosarcina acetivorans
Length = 286
Score = 72.5 bits (170), Expect = 1e-11
Identities = 51/175 (29%), Positives = 83/175 (47%), Gaps = 6/175 (3%)
Frame = +2
Query: 242 IIAEAGQNHQGDXXXXXXXXXXXXXX-GASCVKFQKTCLGEKFTKKYLERPYDNP-NSWG 415
+IAE G NH+G+ VKFQK E T + P+ P NS+G
Sbjct: 6 VIAEIGCNHKGEMEIAHEMIKVAAQFCKVDIVKFQKRTPVELLTPEEYNAPHPVPHNSYG 65
Query: 416 KTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSN 595
KTYGEH+ LEF+ Q+++L ++ + G++++ S D+ + +V++ IKI S +
Sbjct: 66 KTYGEHREFLEFNLDQHKQLKKWCDDWGVVYSTSVWDLTAAKEIVSINPELIKIPSACNL 125
Query: 596 NLLFLKYAASKKIPLI-ISTGMV---DKTAVKTIYDIISSDHKQFCLLHCISAYP 748
L+Y + I +S GM ++ V T ++ K + C S YP
Sbjct: 126 KFDMLEYLCKEYDGEIHLSFGMTTNEEEEKVVTFFE-DRGRGKDLIIYSCTSGYP 179
>UniRef50_Q7NQV6 Cluster: N-acetylneuraminic acid synthase; n=7;
Proteobacteria|Rep: N-acetylneuraminic acid synthase -
Chromobacterium violaceum
Length = 361
Score = 70.5 bits (165), Expect = 4e-11
Identities = 47/145 (32%), Positives = 69/145 (47%), Gaps = 2/145 (1%)
Frame = +2
Query: 230 NPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNS 409
N FIIAEAG NH G GA VKFQ G + + Y +
Sbjct: 2 NHVFIIAEAGVNHNGSLKVALELIDAAKEAGADAVKFQTFKSGAVISMDAPKAEYQKTTT 61
Query: 410 -WGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLV-NLKVPFIKIGS 583
++ + LE S + +L ++ ++ GILF ++ D+ S + LV L VP +K+ S
Sbjct: 62 GTSESQLDMVRKLELSAEDHIQLLQHCEKRGILFLSTPFDVQSAELLVRELGVPQLKVPS 121
Query: 584 GDSNNLLFLKYAASKKIPLIISTGM 658
G+ N FL A +P+I+STGM
Sbjct: 122 GELTNAPFLLKIAGYGLPVIVSTGM 146
>UniRef50_P39625 Cluster: Spore coat polysaccharide biosynthesis
protein spsE; n=2; Bacillus|Rep: Spore coat
polysaccharide biosynthesis protein spsE - Bacillus
subtilis
Length = 373
Score = 70.5 bits (165), Expect = 4e-11
Identities = 51/180 (28%), Positives = 77/180 (42%), Gaps = 3/180 (1%)
Frame = +2
Query: 218 IGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYD 397
+G + P FIIAEAG NH G GA VKFQ + + Y + P
Sbjct: 11 VGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEAGADAVKFQMF----QADRMYQKDPGL 66
Query: 398 NPNSWGKTYGEHK--SHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFI 571
+ GK +E L Y +E ++F ++ D S D L +
Sbjct: 67 YKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQVIFLSTVCDEGSADLLQSTSPSAF 126
Query: 572 KIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSD-HKQFCLLHCISAYP 748
KI S + N+L LKY A P+I ST + + V + I ++ + Q ++HC++ YP
Sbjct: 127 KIASYEINHLPLLKYVARLNRPMIFSTAGAEISDVHEAWRTIRAEGNNQIAIMHCVAKYP 186
>UniRef50_Q04TP3 Cluster: N-acetylneuraminic acid (Sialic acid)
synthetase; n=6; Bacteria|Rep: N-acetylneuraminic acid
(Sialic acid) synthetase - Leptospira borgpetersenii
serovar Hardjo-bovis (strain JB197)
Length = 364
Score = 70.1 bits (164), Expect = 6e-11
Identities = 51/189 (26%), Positives = 90/189 (47%), Gaps = 4/189 (2%)
Frame = +2
Query: 194 VKITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQK---TCLGEK 364
+++ + I G +P ++IAE G NH+G GA KFQ L K
Sbjct: 15 IQLGNKIIAGFFDP-YVIAEIGVNHEGSIDIAKRLIDEAKDGGADGAKFQTYKAETLASK 73
Query: 365 FTKKYLERPYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDF 544
+ Y +R + S + + ++ S F +Y L ++ Q VGI F ++ D+ + +
Sbjct: 74 NSPSYWDRTQEPTASQFELFKKYDS---FGWKEYEILAKHCQSVGIDFLSTPFDLEAVEH 130
Query: 545 LVNLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVK-TIYDIISSDHKQFC 721
L + ++PFIK+ S D ++ L+ A P+I+STG + + ++ ++ +
Sbjct: 131 LAS-QMPFIKVASADITSVPLLRSVAKYSKPVILSTGSSTIPEIDFAMRELHANGANEII 189
Query: 722 LLHCISAYP 748
LLHCI YP
Sbjct: 190 LLHCILNYP 198
>UniRef50_Q1PVV9 Cluster: Similarity to N-acetyl neuramic acid
synthetase NeuB; n=1; Candidatus Kuenenia
stuttgartiensis|Rep: Similarity to N-acetyl neuramic
acid synthetase NeuB - Candidatus Kuenenia
stuttgartiensis
Length = 277
Score = 69.7 bits (163), Expect = 7e-11
Identities = 49/174 (28%), Positives = 76/174 (43%)
Frame = +2
Query: 227 NNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPN 406
+N ++IAE G NH GD G VKFQ T L EK P ++P
Sbjct: 12 DNKVYVIAEIGLNHGGDMNTAKRLIDSASKTGVDAVKFQ-TYLTEK------RVPKNSP- 63
Query: 407 SWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSG 586
+ E ++EL Y + I F ++ D S DFL ++ K+ S
Sbjct: 64 -----IFDILKKCELPFEVFKELKDYTETYNIEFFSTPFDEESVDFLESVNCALYKVASF 118
Query: 587 DSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYP 748
D N L A K +I+S GM + + ++ + I+ + + ++HC+SAYP
Sbjct: 119 DVVNYKLLSKIADTKKTIIMSVGMANLSEIEGAFKILKNKTDKLAIMHCVSAYP 172
>UniRef50_Q7MPQ0 Cluster: Sialic acid synthase; n=3;
Proteobacteria|Rep: Sialic acid synthase - Vibrio
vulnificus (strain YJ016)
Length = 357
Score = 69.3 bits (162), Expect = 1e-10
Identities = 48/155 (30%), Positives = 72/155 (46%), Gaps = 2/155 (1%)
Frame = +2
Query: 242 IIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGK- 418
IIAEAG NH GD GA VKFQ T++ + Y N+ +
Sbjct: 4 IIAEAGVNHNGDEALAFKLVDAAHQAGADIVKFQTFKAKNLVTEQAKQADYQVANTQKQE 63
Query: 419 TYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVN-LKVPFIKIGSGDSN 595
+ S LE S + +L ++ + +GI F ++A D S DFLVN L + +K+ SG+
Sbjct: 64 SQLAMLSRLELSYAAHHQLVKHCESLGIEFLSTAFDSESLDFLVNDLGLTRLKLPSGELT 123
Query: 596 NLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIIS 700
N + A LI+STGM ++ +I+
Sbjct: 124 NAPLVLEHARTGCDLIVSTGMATLAEIEMALGVIA 158
>UniRef50_A1RHT0 Cluster: N-acylneuraminate-9-phosphate synthase;
n=29; cellular organisms|Rep:
N-acylneuraminate-9-phosphate synthase - Shewanella sp.
(strain W3-18-1)
Length = 349
Score = 69.3 bits (162), Expect = 1e-10
Identities = 51/192 (26%), Positives = 82/192 (42%), Gaps = 5/192 (2%)
Frame = +2
Query: 188 VEVKITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKF 367
++V D IG P F+IAE NH GAS +K Q T +
Sbjct: 1 MQVIKVDHCHIGPGQPVFVIAELSGNHGQSLEKAKEMILAAAEAGASAIKLQ-TYTPDTI 59
Query: 368 TKKYLERPY---DNPNSW-GKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVS 535
T + D N W G++ + S ++ LF YA+ +G++ ++ D+ +
Sbjct: 60 TLNVSHGEFFIQDQDNLWKGRSLYDLYSEAMTPWEWHQPLFDYAKSLGLVAFSTPFDLTA 119
Query: 536 FDFLVNLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDH-K 712
++L L VP KI S ++N+ L A P+I+STGM + + ++ +
Sbjct: 120 VEYLEKLNVPCYKIASFENNDHALLAAVAKTGKPVIMSTGMAEIHELAEAVTVLKQHGCR 179
Query: 713 QFCLLHCISAYP 748
LL C S YP
Sbjct: 180 DLILLKCTSHYP 191
>UniRef50_Q97H26 Cluster: Sialic acid synthase; n=14; cellular
organisms|Rep: Sialic acid synthase - Clostridium
acetobutylicum
Length = 350
Score = 68.9 bits (161), Expect = 1e-10
Identities = 56/191 (29%), Positives = 91/191 (47%), Gaps = 10/191 (5%)
Frame = +2
Query: 215 RIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFT----KKYL 382
+IG FIIAE NH D GA +K Q T + T +Y
Sbjct: 11 KIGEGQRTFIIAEMSANHNQDFDRAVEIIKAAKRSGADAIKLQ-TYTPDTITFDSDNEYF 69
Query: 383 ERPYDNPNSWGKTYGEHKSHLE-FSDTQYR-ELFRYAQEVGILFTASAMDMVSFDFLVNL 556
+ W T HK + E ++ Q++ +L A+E G++ +S D S DFL +
Sbjct: 70 Q--IKQGTIWDGTT-LHKLYEEAYTPWQWQPKLKEIAEEEGLICFSSPFDNTSVDFLEKM 126
Query: 557 KVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQ----FCL 724
+VP K+ S + ++ F++Y ASK P+I+STG+ + + IY+ +++ +Q L
Sbjct: 127 EVPAYKVASFELTDIPFIEYIASKGKPVIMSTGIAE---MGEIYEAVAACRRQGNENVIL 183
Query: 725 LHCISAYPGAI 757
L C S+YP +
Sbjct: 184 LKCSSSYPSPL 194
>UniRef50_Q4VKA5 Cluster: NeuNAc condensing enzyme; n=54; cellular
organisms|Rep: NeuNAc condensing enzyme - Escherichia
coli
Length = 350
Score = 68.9 bits (161), Expect = 1e-10
Identities = 56/179 (31%), Positives = 81/179 (45%), Gaps = 9/179 (5%)
Frame = +2
Query: 239 FIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWG- 415
+I+AE G NH GD G VKFQ T E+ KY + G
Sbjct: 9 YIVAEIGCNHNGDFELAKKMVKEAKSAGVDAVKFQ-TFKAEQLISKYAPKAEYQIKVTGN 67
Query: 416 -KTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDS 592
+T E LE ++ +L YA+E+G+ ++ D S DFL + KI SG+
Sbjct: 68 EETQLEMTRKLELPYDEFIKLEEYAKELGLDVFSTPFDFDSIDFLASRNQKVWKIPSGEL 127
Query: 593 NNLLFLKYAASKKI---PLIISTGM--VDK--TAVKTIYDIISSDHKQFCLLHCISAYP 748
NL +L+ A I +++STGM VD+ A+K D H+ +LHC + YP
Sbjct: 128 LNLPYLEKIAKLPIEDKKIVLSTGMATVDEINLALKVFID-NGITHRNITILHCNTEYP 185
>UniRef50_Q12JI6 Cluster: N-acetylneuraminic acid synthase-like
protein; n=1; Shewanella denitrificans OS217|Rep:
N-acetylneuraminic acid synthase-like protein -
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 /
DSM 15013)
Length = 359
Score = 68.5 bits (160), Expect = 2e-10
Identities = 50/195 (25%), Positives = 85/195 (43%), Gaps = 4/195 (2%)
Frame = +2
Query: 185 MVEVKITDDIR-IGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGE 361
M + IT D R IG +IIAE NH+G G +K Q T
Sbjct: 1 MFKASITIDGRHIGPEYQPYIIAELSGNHKGSLSQALAMIDAAAASGVDAIKIQ-TYTAN 59
Query: 362 KFTKKYLERPYD-NPNSW-GKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVS 535
T ++ + N W G+T + ++ LF +A++ + +S D+ +
Sbjct: 60 TITLQHDGPEFRINGGLWKGRTLFDLYEEAHTPWEWHKSLFEHAKKQNVTLFSSPFDLKA 119
Query: 536 FDFLVNLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAV-KTIYDIISSDHK 712
+ L + + P KI S + N++ + AA P+++STG+ + + + + ++
Sbjct: 120 IELLESCECPAYKISSFEINDIGLIMAAAKTGKPIVMSTGLATLAEIEEAVEAVANAGGT 179
Query: 713 QFCLLHCISAYPGAI 757
Q LLHCIS YP I
Sbjct: 180 QLALLHCISGYPTPI 194
>UniRef50_A3PE56 Cluster: Sialic acid synthase; n=1; Prochlorococcus
marinus str. MIT 9301|Rep: Sialic acid synthase -
Prochlorococcus marinus (strain MIT 9301)
Length = 341
Score = 68.1 bits (159), Expect = 2e-10
Identities = 49/177 (27%), Positives = 80/177 (45%), Gaps = 8/177 (4%)
Frame = +2
Query: 242 IIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTK--KYLERPYDNPNSWG 415
+IAEAG NH G GA +KFQ T E L + NS+
Sbjct: 5 VIAEAGVNHNGSLDLALKLVEEAKLSGADSIKFQ-TFKSESLASFSAPLAQYQKKSNSYK 63
Query: 416 KTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSN 595
KS LE +D + +F + E+GI F +S + FL++L + IKI SG+
Sbjct: 64 SQIDMLKS-LELTDKDTKRIFSFCNEIGIEFMSSPFGVDELHFLLDLGMLSIKIPSGEIT 122
Query: 596 NLLFL----KYAASKKIPLIISTGMVDKTAVKTIYDII--SSDHKQFCLLHCISAYP 748
N + K+ + I +++STGM ++ ++ ++ ++HC+S+YP
Sbjct: 123 NYALISEIGKFISEGNINVLLSTGMSSLGDIEEALSLLRFKETLERITIMHCVSSYP 179
>UniRef50_Q30V22 Cluster: N-acylneuraminate-9-phosphate synthase;
n=1; Desulfovibrio desulfuricans G20|Rep:
N-acylneuraminate-9-phosphate synthase - Desulfovibrio
desulfuricans (strain G20)
Length = 344
Score = 67.7 bits (158), Expect = 3e-10
Identities = 58/183 (31%), Positives = 75/183 (40%), Gaps = 6/183 (3%)
Frame = +2
Query: 218 IGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYD 397
I NP F+IAE G NH+GD GA VK Q G+ + +E P
Sbjct: 5 ISDKNPVFVIAEIGGNHEGDFAYARKLVSLAIESGADAVKLQ-VYAGDALVSR-VESPDR 62
Query: 398 NPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKI 577
N H E S QY L + G+ F ASA D + + V K
Sbjct: 63 N---------RHFKKFELSRGQYEALIDMCRHAGVQFMASAWDRERLGW-IEPHVRIHKA 112
Query: 578 GSGDSNNLLFLKYAASKKIPLIISTGMVD----KTAVKTIYDIISS--DHKQFCLLHCIS 739
GSGD L+ S PL++STG+ + AV+ I + SS + LL C S
Sbjct: 113 GSGDLTAYPMLRALVSTGKPLVLSTGLSTMPEVEAAVRYIGSLDSSYITQGKLALLQCSS 172
Query: 740 AYP 748
AYP
Sbjct: 173 AYP 175
>UniRef50_A4MIF1 Cluster: N-acylneuraminate-9-phosphate synthase;
n=1; Geobacter bemidjiensis Bem|Rep:
N-acylneuraminate-9-phosphate synthase - Geobacter
bemidjiensis Bem
Length = 338
Score = 67.7 bits (158), Expect = 3e-10
Identities = 49/173 (28%), Positives = 79/173 (45%), Gaps = 1/173 (0%)
Frame = +2
Query: 233 PCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSW 412
P +IIAE G N G VK Q T E + K +D N+
Sbjct: 10 PIYIIAEIGGNFT-TFEEAKALVDAAASCGVDAVKLQ-TYRAETVSSK--SAIFDMENTG 65
Query: 413 GKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDS 592
+ E E + +R++F Y + G+ + ++ D L L V KIGS D+
Sbjct: 66 IASQFELFQKYEIDEELHRQVFDYIRAKGLDWFSTPSHEADVDLLDRLGVSAYKIGSDDA 125
Query: 593 NNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDII-SSDHKQFCLLHCISAYP 748
N+ FL+Y A+K P++++TGM V+ D+I + + + LLH +++YP
Sbjct: 126 VNIPFLRYVAAKGKPVLLATGMCTMQEVRESVDVILGAGNLELILLHAVTSYP 178
>UniRef50_A0LYV7 Cluster: N-acetylneuraminate synthase; n=1;
Gramella forsetii KT0803|Rep: N-acetylneuraminate
synthase - Gramella forsetii (strain KT0803)
Length = 332
Score = 67.3 bits (157), Expect = 4e-10
Identities = 47/169 (27%), Positives = 72/169 (42%)
Frame = +2
Query: 242 IIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGKT 421
+IAE GQ H+G G VKFQ + E LE + KT
Sbjct: 3 VIAEVGQAHEGSLGMALSYIGALAEAGVDAVKFQ-VHIAEA-ESSILEPFRIKFSEQDKT 60
Query: 422 YGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNNL 601
++ +EFS +++ + + ++ + F AS + D L + V KIGSG+ NN
Sbjct: 61 RFDYWKRMEFSTDEWKLIKKTCEDNNVEFLASPFSNAAVDLLEEVGVKRYKIGSGEVNNF 120
Query: 602 LFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYP 748
L L+ A +IIS+GM + + F LL C ++YP
Sbjct: 121 LLLEKIAKTGKQVIISSGMSSFDELDATVSFLRERKISFSLLQCTTSYP 169
>UniRef50_UPI0000384B44 Cluster: COG2089: Sialic acid synthase; n=1;
Magnetospirillum magnetotacticum MS-1|Rep: COG2089:
Sialic acid synthase - Magnetospirillum magnetotacticum
MS-1
Length = 346
Score = 66.1 bits (154), Expect = 9e-10
Identities = 59/177 (33%), Positives = 76/177 (42%), Gaps = 7/177 (3%)
Frame = +2
Query: 239 FIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGE---KFTKK--YLERPYDNP 403
FIIAEAG NH GD A VKFQ GE +F K YLE +
Sbjct: 14 FIIAEAGVNHDGDIQRAKRLIDVAAEAQADAVKFQTWRPGEITGRFAYKVNYLEATTEQA 73
Query: 404 NSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLV-NLKVPFIKIG 580
S Y E L +REL + + GILF ++ S FLV L +P +KIG
Sbjct: 74 ES---RY-ELSCRLALPYPVFRELKSHCEARGILFLSTPDGFDSLAFLVGELDMPIVKIG 129
Query: 581 SGDSNNLLFLKYAASKKIPLIISTGMVDKTAV-KTIYDIISSDHKQFCLLHCISAYP 748
S + + +L+ P I+STG+ V K + + LLHC S YP
Sbjct: 130 STEVTHPQYLEAIGRTGRPAILSTGLSTLGEVEKAVAALRRGGVGPLALLHCTSEYP 186
>UniRef50_Q93NQ2 Cluster: NnaB; n=7; Bacteria|Rep: NnaB -
Escherichia coli
Length = 346
Score = 64.9 bits (151), Expect = 2e-09
Identities = 48/178 (26%), Positives = 79/178 (44%), Gaps = 8/178 (4%)
Frame = +2
Query: 239 FIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGK 418
+I+AE G NH GD G VKFQ T ++ KY + G
Sbjct: 5 YIVAEIGCNHNGDFNLAKKMVEEAKKAGVDAVKFQ-TFKADQLISKYAPKAEYQIKVTGN 63
Query: 419 TYG--EHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDS 592
E LE ++ +L YA+E+G+ ++ D S DFL + KI SG+
Sbjct: 64 QESQLEMTRKLELPYEEFIKLEEYAKELGLDVFSTPFDFESIDFLASRNQKMWKIPSGEL 123
Query: 593 NNLLFLKYAASKKI---PLIISTGMVDKTAVKTIYDIISSD---HKQFCLLHCISAYP 748
NL +L+ + I +++STGM +K ++++ + ++ +LHC + YP
Sbjct: 124 LNLPYLEKISRLPIEGKEIVLSTGMATIEEIKASVNVLTKNGMAPEKITILHCNTEYP 181
>UniRef50_A3Y8V9 Cluster: NeuB family protein; n=1; Marinomonas sp.
MED121|Rep: NeuB family protein - Marinomonas sp. MED121
Length = 347
Score = 64.5 bits (150), Expect = 3e-09
Identities = 48/178 (26%), Positives = 76/178 (42%), Gaps = 5/178 (2%)
Frame = +2
Query: 239 FIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGK 418
FIIAE NH D G +K Q T + T +
Sbjct: 11 FIIAELSGNHNQDFALAKAMIEAAAKTGVDAIKLQ-TYTADSMTLNVRNEEFMVSAQGSL 69
Query: 419 TYGEHKSHLEF-SDTQY---RELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSG 586
G++ L + T Y + LF YA+ +G++ +S D+ + +FL +L VP KI S
Sbjct: 70 WEGDNLYDLYAKASTPYEWHQPLFDYAKSLGLVAFSSPFDINAVNFLESLDVPIYKIASF 129
Query: 587 DSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIIS-SDHKQFCLLHCISAYPGAI 757
+ +L ++ A P+I+STGM K+ ++ ++ + LL C S YP I
Sbjct: 130 ELTDLPLIEAVARTGKPMIMSTGMATKSEIEEAVSLVRLIGDNEITLLKCTSTYPAKI 187
>UniRef50_Q7VHQ5 Cluster: Sialic acid synthase; n=6;
Helicobacter|Rep: Sialic acid synthase - Helicobacter
hepaticus
Length = 349
Score = 63.7 bits (148), Expect = 5e-09
Identities = 51/181 (28%), Positives = 78/181 (43%), Gaps = 9/181 (4%)
Frame = +2
Query: 242 IIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPN---SW 412
IIAE NH GA VK Q +T + L + P+ S
Sbjct: 15 IIAELSANHNQSLEIAKDSIRAIAACGADGVKLQT------YTPECLTLQSNEPHFCISG 68
Query: 413 GKTYGEHKSHLEFSDTQ-----YRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKI 577
G + + + + + Q ++ELF A+E+G+L +S FL +L+ P K+
Sbjct: 69 GTLWDKRNLYELYKEAQTPWEWHKELFSLAKELGLLIFSSPFSPKGVAFLESLQCPIYKV 128
Query: 578 GSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISS-DHKQFCLLHCISAYPGA 754
S + + ++ A K P+IISTG+ +KT +I K LLHCIS YP
Sbjct: 129 ASFEVMHYELIEAIAKTKKPIIISTGVATHKELKTALEICHKYGCKDITLLHCISEYPAP 188
Query: 755 I 757
+
Sbjct: 189 L 189
>UniRef50_Q726U8 Cluster: NeuB family protein; n=2; Desulfovibrio
vulgaris subsp. vulgaris|Rep: NeuB family protein -
Desulfovibrio vulgaris (strain Hildenborough / ATCC
29579 / NCIMB8303)
Length = 358
Score = 63.7 bits (148), Expect = 5e-09
Identities = 50/177 (28%), Positives = 69/177 (38%), Gaps = 1/177 (0%)
Frame = +2
Query: 242 IIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGKT 421
IIAE G NH GD GA VK Q F L P
Sbjct: 24 IIAEVGLNHGGDADLAWEMIESAWEHGADLVKLQS------FAPGGLLHP-------SLP 70
Query: 422 YGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNNL 601
Y + S Q+ LF A+ GI + D + D ++ +K+ S D +N
Sbjct: 71 YAASMEGMMLSLRQHEALFERARRQGIALITTPFDAPTLDLCTRFRIAAVKVASMDLDNT 130
Query: 602 LFLKYAASKKIPLIISTGMVDKTAV-KTIYDIISSDHKQFCLLHCISAYPGAI*RLQ 769
L+ A +P+I+S GM D + K + + S LLHCIS YP + +Q
Sbjct: 131 AHLRAVARTGLPVILSCGMGDHADIGKALATLRESGATDVTLLHCISDYPARLEDMQ 187
>UniRef50_Q46675 Cluster: NeuB protein; n=8; Bacteria|Rep: NeuB
protein - Escherichia coli
Length = 346
Score = 63.7 bits (148), Expect = 5e-09
Identities = 52/178 (29%), Positives = 73/178 (41%), Gaps = 8/178 (4%)
Frame = +2
Query: 239 FIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGK 418
+I+AE G NH G G + VKFQ T +K + + G+
Sbjct: 5 YIVAEIGCNHNGSVDIAREMILKAKEAGVNAVKFQ-TFKADKLISAIAPKAEYQIKNTGE 63
Query: 419 TYG--EHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDS 592
E LE Y L YA + + ++ D S DFL +LK KI SG+
Sbjct: 64 LESQLEMTKKLEMKYDDYLHLMEYAVSLNLDVFSTPFDEDSIDFLASLKQKIWKIPSGEL 123
Query: 593 NNLLFLKYAASKKIP---LIISTGMVDKTAVKTIYDIISSDH---KQFCLLHCISAYP 748
NL +L+ A IP +IISTGM +K I ++ +LHC + YP
Sbjct: 124 LNLPYLEKIAKLPIPDKKIIISTGMATIDEIKQSVSIFINNKVPVGNITILHCNTEYP 181
>UniRef50_A1WSD6 Cluster: N-acylneuraminate-9-phosphate synthase;
n=1; Verminephrobacter eiseniae EF01-2|Rep:
N-acylneuraminate-9-phosphate synthase -
Verminephrobacter eiseniae (strain EF01-2)
Length = 352
Score = 63.7 bits (148), Expect = 5e-09
Identities = 43/177 (24%), Positives = 75/177 (42%), Gaps = 3/177 (1%)
Frame = +2
Query: 236 CFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWG 415
C +I E G NH G +K Q+ ++ + Y G
Sbjct: 16 CIVIGEIGVNHNRQQDMLFRLIDEGIAAGLDVIKLQRFKAEQEIAMQAPAADYQKRAGAG 75
Query: 416 KTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVN-LKVPFIKIGSGDS 592
++ + LE D + F Y ++ G+ F +A D S DFL + L +KI S +
Sbjct: 76 ESQLQMARQLELPDAWLTQAFDYCRQRGVGFLCTAFDHGSVDFLADRLGCKTVKIPSPEV 135
Query: 593 NNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSD--HKQFCLLHCISAYPGAI 757
+N L++ A + L++STG V D ++++ ++ L+HC+S YP +
Sbjct: 136 SNKPLLQHMARRFDGLLLSTGASYLGEVANAIDWLAAEAGPRELALMHCLSEYPAPV 192
>UniRef50_Q11RF6 Cluster: N-acetylneuraminic acid synthetase; n=2;
Flexibacteraceae|Rep: N-acetylneuraminic acid synthetase
- Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB
9469)
Length = 348
Score = 61.3 bits (142), Expect = 3e-08
Identities = 48/181 (26%), Positives = 79/181 (43%), Gaps = 4/181 (2%)
Frame = +2
Query: 218 IGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQK-TCLGEKFTKKYLERPY 394
I N+ F+IAE NH GA +K Q T F E
Sbjct: 9 ISENHKPFVIAEMSGNHNQSLDRALAIVDAAAAAGAHALKLQTYTADTITFNGTSDEFII 68
Query: 395 DNPNSWGKTYGEHKSHLE-FSDTQYRE-LFRYAQEVGILFTASAMDMVSFDFLVNLKVPF 568
+ NS K H+ + + ++ ++ +F A+ G++ +S D + DFL +L VP
Sbjct: 69 KDENSIWKNQNLHQLYQQAYTPWEWHAPIFERAKSHGMIAFSSPFDTTAVDFLESLDVPC 128
Query: 569 IKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDH-KQFCLLHCISAY 745
KI S ++ + + LK A P+I+STG+ ++ ++ + K+ LL C S Y
Sbjct: 129 YKIASFENTDHILLKKVAQTNKPVIMSTGVSTIADIQESVKVLRDNGCKELVLLKCTSTY 188
Query: 746 P 748
P
Sbjct: 189 P 189
>UniRef50_A4U183 Cluster: N-acetylneuraminate synthase; n=1;
Magnetospirillum gryphiswaldense|Rep:
N-acetylneuraminate synthase - Magnetospirillum
gryphiswaldense
Length = 354
Score = 61.3 bits (142), Expect = 3e-08
Identities = 45/143 (31%), Positives = 65/143 (45%), Gaps = 2/143 (1%)
Frame = +2
Query: 242 IIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWG-K 418
IIAEAG NH G GA VKFQ + Y N G +
Sbjct: 5 IIAEAGVNHDGKIDQALRLIDAAAAAGADVVKFQTFKAAALASAVAGRAEYQIRNLGGTE 64
Query: 419 TYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVN-LKVPFIKIGSGDSN 595
+ + LE S+ + L + ++ GI F +S D +S +FL++ L + IK+GSG+
Sbjct: 65 SQLDMLRRLELSEDDHFRLRDHCRQAGIGFLSSPFDRLSLEFLIDRLGLDTIKLGSGELT 124
Query: 596 NLLFLKYAASKKIPLIISTGMVD 664
N L A + +I+STGM D
Sbjct: 125 NGPLLLQAGASGRNIILSTGMAD 147
>UniRef50_A2BSE7 Cluster: Sialic acid synthase; n=1; Prochlorococcus
marinus str. AS9601|Rep: Sialic acid synthase -
Prochlorococcus marinus (strain AS9601)
Length = 356
Score = 61.3 bits (142), Expect = 3e-08
Identities = 45/173 (26%), Positives = 75/173 (43%), Gaps = 4/173 (2%)
Frame = +2
Query: 242 IIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQ---KTCLGEKFTKKYLERPYDNPNSW 412
IIAE G NH GD G VKFQ + K +K Y + + S
Sbjct: 23 IIAEIGVNHGGDIDKAIAMIDDVKNNGGDAVKFQTYKANLIARKDSKAYWDTTKEKTMSQ 82
Query: 413 GKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDS 592
+ + ++ +F +++++ Y + +LF ++ D S ++ +N K+ S D
Sbjct: 83 FELFSKYD---KFGLEEFKKIEDYCKRKSVLFMSTPFDSYSANY-INQLSKIHKVASVDI 138
Query: 593 NNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHK-QFCLLHCISAYP 748
N + + AS +I+STG + +K +I S K LLHC+ YP
Sbjct: 139 TNHILISQLASYGKDIILSTGASNLDEIKAAVSLIESKSKISPALLHCVVNYP 191
>UniRef50_A4BEM9 Cluster: Sialic acid synthase; n=1; Reinekea sp.
MED297|Rep: Sialic acid synthase - Reinekea sp. MED297
Length = 354
Score = 58.4 bits (135), Expect = 2e-07
Identities = 45/144 (31%), Positives = 61/144 (42%)
Frame = +2
Query: 227 NNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPN 406
N+ F+IAEAG NH GD GA +KFQ T + E +
Sbjct: 3 NDSVFLIAEAGVNHNGDVELAKELIELAAAAGADAIKFQ-TFIPEALVTTTARKAGYQKT 61
Query: 407 SWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSG 586
+ ++ L + EL YA I F ++A + S L L V KI SG
Sbjct: 62 AHEESQLAMLQALALPLPVFDELKAYADSKAIEFMSTAFESESLALLSQLAVRRYKIPSG 121
Query: 587 DSNNLLFLKYAASKKIPLIISTGM 658
+ NL FL A+ + LI+STGM
Sbjct: 122 ELTNLPFLIEHAALQQDLILSTGM 145
>UniRef50_Q3B0R9 Cluster: N-acylneuraminate-9-phosphate synthase;
n=1; Synechococcus sp. CC9902|Rep:
N-acylneuraminate-9-phosphate synthase - Synechococcus
sp. (strain CC9902)
Length = 349
Score = 57.6 bits (133), Expect = 3e-07
Identities = 44/181 (24%), Positives = 71/181 (39%), Gaps = 4/181 (2%)
Frame = +2
Query: 227 NNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQK----TCLGEKFTKKYLERPY 394
+NP + IA+ G NH GA KFQ + + + K+
Sbjct: 7 DNPLYFIADIGANHDSSLKRAKALIKTAAESGADAAKFQNFFAHSIVSDLGFKQLPNSIL 66
Query: 395 DNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIK 574
+ W ++ + S EL Y +E GI + + D+ +FL N V K
Sbjct: 67 SHQAEWTESVFDVYDKASLSLEWTEELHSYCKECGISYMTTPYDISILEFL-NQYVACWK 125
Query: 575 IGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYPGA 754
IGSGD L + + P+ I+TG + T V + + K+ L+ C + Y G
Sbjct: 126 IGSGDITWLDLISKVSQLGKPIAIATGASNFTEVCQAVNTVLQHTKKIILMQCNTNYTGC 185
Query: 755 I 757
+
Sbjct: 186 L 186
>UniRef50_Q2BI17 Cluster: N-acetylneuraminate synthase; n=4;
Bacteria|Rep: N-acetylneuraminate synthase -
Neptuniibacter caesariensis
Length = 363
Score = 56.8 bits (131), Expect = 6e-07
Identities = 46/189 (24%), Positives = 73/189 (38%), Gaps = 3/189 (1%)
Frame = +2
Query: 200 ITDDIRIGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQK---TCLGEKFT 370
I + I ++P + IA+ NH GD GA KFQ + F
Sbjct: 11 IVNSHSISESDPTYFIADIAANHDGDLEKAKELIWLSAEAGADAAKFQHFKADTIVSDFG 70
Query: 371 KKYLERPYDNPNSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLV 550
K L + ++W K+ E + E EL ++ I F S D D++
Sbjct: 71 FKSLGGQQSHQSTWEKSVYEVYADAEVDLNWTEELVNTCKQAEIDFFTSPYDFDLADYID 130
Query: 551 NLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLH 730
VP KIGSGD L++ A K P ++TG + V + + + L+
Sbjct: 131 QF-VPAHKIGSGDITWHAMLEHIAKKNKPYFLATGASELADVVAAVEACLKINPKLVLMQ 189
Query: 731 CISAYPGAI 757
C + Y ++
Sbjct: 190 CNTNYTASL 198
>UniRef50_Q0P8U0 Cluster: Pse synthetase; n=14; Campylobacter|Rep:
Pse synthetase - Campylobacter jejuni
Length = 343
Score = 56.4 bits (130), Expect = 7e-07
Identities = 50/179 (27%), Positives = 75/179 (41%), Gaps = 6/179 (3%)
Frame = +2
Query: 239 FIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGK 418
FIIAE NH G GA +K Q T + T L ++ G
Sbjct: 13 FIIAELSANHAGSLEMALKSIKAAKKAGADAIKIQ-TYTPDSLT---LNSDKEDFIIKGG 68
Query: 419 TYGEHKSH--LEFSDTQYR---ELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGS 583
+ + K + E + T Y ++F AQ GIL +S +FL KI S
Sbjct: 69 LWDKRKLYELYESAKTPYEWHSQIFETAQNEGILCFSSPFAKEDVEFLKRFDPIAYKIAS 128
Query: 584 GDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSD-HKQFCLLHCISAYPGAI 757
++N+ F++ A +K P I+STG+ + + I +I + + L C S YP AI
Sbjct: 129 FEANDENFVRLIAKEKKPTIVSTGIATEEELFKICEIFKEEKNPDLVFLKCTSTYPTAI 187
>UniRef50_A6W187 Cluster: N-acylneuraminate-9-phosphate synthase;
n=2; Proteobacteria|Rep: N-acylneuraminate-9-phosphate
synthase - Marinomonas sp. MWYL1
Length = 343
Score = 56.4 bits (130), Expect = 7e-07
Identities = 43/178 (24%), Positives = 73/178 (41%), Gaps = 5/178 (2%)
Frame = +2
Query: 239 FIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPY---DNPNS 409
FIIAE NH D G +K Q T + T + ++ +
Sbjct: 11 FIIAELSGNHDQDFELAKAMIHAAAEAGVDAIKLQ-TYTPDTMTLDVRHGEFMVSESDSL 69
Query: 410 W-GKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSG 586
W G + ++ LF A+ +G++ +S D+ + FL ++ VP KI S
Sbjct: 70 WRGSNLYDLYKKASTPWEWHKPLFELAESLGLVAFSSPFDLSAVAFLESIDVPLYKIASF 129
Query: 587 DSNNLLFLKYAASKKIPLIISTGMVDKTAV-KTIYDIISSDHKQFCLLHCISAYPGAI 757
+ ++ ++ A P+I+STGM + + + + I + LL C S YP I
Sbjct: 130 EMTDIPLIQAVARTGKPIIMSTGMASEEEIAEAVATIRAIGDNPLTLLKCTSTYPSKI 187
>UniRef50_A4U173 Cluster: NeuB; n=1; Magnetospirillum
gryphiswaldense|Rep: NeuB - Magnetospirillum
gryphiswaldense
Length = 337
Score = 55.6 bits (128), Expect = 1e-06
Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Frame = +2
Query: 446 EFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNNLLFLKYAAS 625
E + + EL +E+G+ + ++ + D L K GS D N FL+ A
Sbjct: 77 ELTRDDHVELIDLCRELGVAWMSTPSHVSDLDLLEPFDPIAYKTGSDDLTNTRFLRQIAE 136
Query: 626 KKIPLIISTGMVDKTAVKTIYDIIS-SDHKQFCLLHCISAYP 748
K P+++STGM ++ D+I+ + + + LLHC+ +YP
Sbjct: 137 KGRPMVVSTGMCTLAEIERAVDVITRTGNTELILLHCVVSYP 178
>UniRef50_Q2IZW6 Cluster: N-acetylneuraminate synthase; n=1;
Rhodopseudomonas palustris HaA2|Rep: N-acetylneuraminate
synthase - Rhodopseudomonas palustris (strain HaA2)
Length = 332
Score = 52.8 bits (121), Expect = 9e-06
Identities = 48/174 (27%), Positives = 69/174 (39%)
Frame = +2
Query: 227 NNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPN 406
+NP +IIAE G H G GA VKFQ T + E T P
Sbjct: 5 SNP-YIIAEIGSVHDGSFGNACRLLETAAECGADAVKFQ-THIAEAETLPNAPSPSYFSA 62
Query: 407 SWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSG 586
Y + FS Q+R L A+ + F +S + + D L ++ V KI SG
Sbjct: 63 EPRTAYFKRTG---FSPEQWRALAALAKSTKVDFLSSPFSLEAVDLLEDVGVAAYKIPSG 119
Query: 587 DSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYP 748
+ +N+ L A P+ +S+GM + + + LL C S YP
Sbjct: 120 EVSNIPLLSRIAQTGKPVFLSSGMSNWEELDAAVGALRG--SALTLLQCTSKYP 171
>UniRef50_Q0YTS4 Cluster: N-acylneuraminate-9-phosphate synthase;
n=5; Bacteria|Rep: N-acylneuraminate-9-phosphate
synthase - Chlorobium ferrooxidans DSM 13031
Length = 354
Score = 52.8 bits (121), Expect = 9e-06
Identities = 43/187 (22%), Positives = 76/187 (40%), Gaps = 7/187 (3%)
Frame = +2
Query: 218 IGGNNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYD 397
+G +P FI+AE NH G GA +K Q T + T + +
Sbjct: 15 LGPGHPAFIVAEMSGNHGGSLEYALEIVHAAKRSGADAIKLQ-TYTADTITLNSDRQDFC 73
Query: 398 NPNSWGKTYGEHKSHLEFSDTQY------RELFRYAQEVGILFTASAMDMVSFDFLVNLK 559
P+ G + +H + + Y +FR A+ + + +S D + + L L
Sbjct: 74 IPS--GTPWADHSTLWSLYNKAYTPWDWHESIFREARSLDLEIFSSPFDESAVELLEQLG 131
Query: 560 VPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVDKTAVK-TIYDIISSDHKQFCLLHCI 736
KI S + ++ L A P+I+STG+ ++ + + ++ + LL C
Sbjct: 132 ASAYKIASPEITHIPLLDKVARTGKPVILSTGLAALEDIELALATLRAAGSGEIILLKCT 191
Query: 737 SAYPGAI 757
+AYP I
Sbjct: 192 TAYPAPI 198
>UniRef50_A5W0I0 Cluster: N-acetylneuraminic acid synthase,
N-terminal domain; n=1; Pseudomonas putida F1|Rep:
N-acetylneuraminic acid synthase, N-terminal domain -
Pseudomonas putida F1
Length = 369
Score = 50.8 bits (116), Expect = 4e-05
Identities = 30/118 (25%), Positives = 48/118 (40%)
Frame = +2
Query: 422 YGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNNL 601
Y + + ++ + + + + A+ D S D V +P IKI S D N+
Sbjct: 74 YVKKTEDTRLTKAEFARMVEEVRNLSCIPMATPFDEASVDLCVEFDMPIIKIASSDMNDW 133
Query: 602 LFLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQFCLLHCISAYPGAI*RLQSD 775
++ AS + P IISTG + + I + HC+S YP LQ D
Sbjct: 134 PLIEKIASTRRPTIISTGGASEKDLDDIVRYFEKRDIPLAINHCVSLYPSEDDELQLD 191
>UniRef50_Q0AN71 Cluster: N-acetylneuraminate synthase; n=1;
Maricaulis maris MCS10|Rep: N-acetylneuraminate synthase
- Maricaulis maris (strain MCS10)
Length = 305
Score = 49.6 bits (113), Expect = 9e-05
Identities = 44/172 (25%), Positives = 69/172 (40%), Gaps = 1/172 (0%)
Frame = +2
Query: 242 IIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGKT 421
+IAE G NH GD GA VKFQ T E +++ + D +
Sbjct: 6 VIAEIGSNHGGDLDQAKRYIEASAKAGADVVKFQ-TLTREGLIARFV-KGADGTVTENPK 63
Query: 422 YGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNNL 601
+ + D + L A + G+ F ++ + + + + +L V KI SGD
Sbjct: 64 FAAF-GNAGLPDDWHAPLMTCAADNGVEFMSTPFSLDAVELMESLGVKRYKIASGDLTFT 122
Query: 602 LFLKYAASKKIPLIISTGMVDKTAVKT-IYDIISSDHKQFCLLHCISAYPGA 754
L+ + LI+STG V T + + S LHC ++YP A
Sbjct: 123 PLLEALGATGKRLILSTGASYLDEVTTAVTTLTRSGCPHLTALHCAASYPPA 174
>UniRef50_O83573 Cluster: Spore coat polysaccharide biosynthesis
protein; n=1; Treponema pallidum|Rep: Spore coat
polysaccharide biosynthesis protein - Treponema pallidum
Length = 378
Score = 49.2 bits (112), Expect = 1e-04
Identities = 46/171 (26%), Positives = 68/171 (39%), Gaps = 3/171 (1%)
Frame = +2
Query: 245 IAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGKTY 424
IAE G H G A+ VKFQ E L P+ Y
Sbjct: 18 IAEIGSAHAGSFDRARALIDAAADAAAAAVKFQLIYAHEILHP--LTGAVRLPSGAVSLY 75
Query: 425 GEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNNLL 604
+ LE + Y + F +A+ G+L S S + LK F+K+ S + N
Sbjct: 76 -QRFEELEVPLSFYAQCFNHARSRGMLVGISPFGPRSATEALALKPDFLKVASPELNYPT 134
Query: 605 FLKYAASKKIPLIISTGMVDKTAVKTIYDIISSDHKQ---FCLLHCISAYP 748
+ A+ ++PLI+S+G+ ++ KQ LLHCI+AYP
Sbjct: 135 LISTLAAAELPLILSSGVCLLKEIEGALAQCRQYTKQGSSHALLHCITAYP 185
>UniRef50_A0LAB4 Cluster: N-acetylneuraminic acid synthase,
N-terminal domain; n=2; Proteobacteria|Rep:
N-acetylneuraminic acid synthase, N-terminal domain -
Magnetococcus sp. (strain MC-1)
Length = 500
Score = 47.6 bits (108), Expect = 3e-04
Identities = 44/179 (24%), Positives = 72/179 (40%), Gaps = 6/179 (3%)
Frame = +2
Query: 239 FIIAEAGQN----HQG-DXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNP 403
+IIAEAG N H D GA VKFQ + + + Y
Sbjct: 161 YIIAEAGSNWRMGHPARDLAMGKALIDAAVVSGADAVKFQTYRPEKVYVANAGQSNYLAE 220
Query: 404 NSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGS 583
+ + + + L + +L Y ++ GI F ++ + F ++ VP KI S
Sbjct: 221 SGIKQDIRDIFADLAMPYSMIEDLAGYCKKAGIQFLSTGFSVEDFQ-AIDPWVPLHKIAS 279
Query: 584 GDSNNLLFLKYAASKKIPLIISTGMVDKTAVK-TIYDIISSDHKQFCLLHCISAYPGAI 757
+ ++L L AA+ PL++STG + + S + CLL C + YP +
Sbjct: 280 YEISHLRLLDLAANSGKPLLLSTGASRAEDIAWAVERYHSQGGRDLCLLQCTAKYPAPL 338
>UniRef50_Q2BJD7 Cluster: N-acetylneuraminic acid synthetase; n=1;
Neptuniibacter caesariensis|Rep: N-acetylneuraminic acid
synthetase - Neptuniibacter caesariensis
Length = 270
Score = 44.4 bits (100), Expect = 0.003
Identities = 41/171 (23%), Positives = 69/171 (40%), Gaps = 3/171 (1%)
Frame = +2
Query: 245 IAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPNSWGKTY 424
IAE G N GD GA+ KFQ +K +DN G+
Sbjct: 4 IAEIGWNFMGDMKLAEDMIAAAAQSGATTAKFQYWN-----PEKLKAGAWDND---GRRE 55
Query: 425 GEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNNLL 604
+K+ L Q +L + + F S + +F+ IKI S + N+
Sbjct: 56 IYNKACLNADKIQ--QLTELCSKHNVKFLLSVFNKEDAEFVSQFSTEAIKIPSHEVANIE 113
Query: 605 FLKYAASKKIPLIISTGMVDKTAVKTIYDI---ISSDHKQFCLLHCISAYP 748
++YA S + +S G + +K + ++ I S+ + +HC+S+YP
Sbjct: 114 LIRYALSTYKRVFLSLGACTEEELKDVSELVGSIRSNGEDVVAMHCVSSYP 164
>UniRef50_A7DQU2 Cluster: N-acylneuraminate-9-phosphate synthase;
n=1; Candidatus Nitrosopumilus maritimus SCM1|Rep:
N-acylneuraminate-9-phosphate synthase - Candidatus
Nitrosopumilus maritimus SCM1
Length = 351
Score = 44.0 bits (99), Expect = 0.004
Identities = 41/176 (23%), Positives = 65/176 (36%), Gaps = 6/176 (3%)
Frame = +2
Query: 239 FIIAEAGQN-----HQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNP 403
F+IAEAG N + D GA VKFQ + Y
Sbjct: 14 FVIAEAGSNWKCGDYSDDLEQAKKLIETAAKAGADAVKFQTYKPETIYVSDAGNSDYLEK 73
Query: 404 NSWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGS 583
+ E HL EL +Y E I F ++ + V+ K+ S
Sbjct: 74 YGIKENINEIFEHLSMPYEMIPELKKYCDEKNIQFMSTPFSVQDAKE-VDKFTEIHKVAS 132
Query: 584 GDSNNLLFLKYAASKKIPLIISTGMVDKTAVKTIYDII-SSDHKQFCLLHCISAYP 748
+ N++ L++ A + P+I+STG + ++I + + L+ C S YP
Sbjct: 133 FEINHIRLLEFLAKTQKPIIVSTGASTFKEIDFAINLIRKNGNDNIALMQCTSKYP 188
>UniRef50_Q0IDQ4 Cluster: NeuB family protein; n=1; Synechococcus
sp. CC9311|Rep: NeuB family protein - Synechococcus sp.
(strain CC9311)
Length = 353
Score = 43.6 bits (98), Expect = 0.006
Identities = 24/65 (36%), Positives = 35/65 (53%)
Frame = +2
Query: 461 QYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNNLLFLKYAASKKIPL 640
Q+RELF + G+ F S + S DF V+ IKI S + N L ++ +A +PL
Sbjct: 96 QHRELFNLIKSYGLNFIVSVYTLESVDFAVSEGAIAIKIASSNINFLPLIEKSARTGLPL 155
Query: 641 IISTG 655
+I TG
Sbjct: 156 LIDTG 160
>UniRef50_Q8EC83 Cluster: Polysaccharide biosynthesis
related-protein; n=6; Proteobacteria|Rep: Polysaccharide
biosynthesis related-protein - Shewanella oneidensis
Length = 290
Score = 37.9 bits (84), Expect = 0.28
Identities = 48/181 (26%), Positives = 71/181 (39%), Gaps = 7/181 (3%)
Frame = +2
Query: 227 NNPCFIIAEAGQNHQGDXXXXXXXXXXXXXXGASCVKFQKTCLGEKFTKKYLERPYDNPN 406
++P FI AE NH D G VKFQ + E F + L +
Sbjct: 4 HSPLFI-AEVSSNHHRDLQRCIEFIKTAAEIGCDAVKFQLFKIEELFAPEILSK------ 56
Query: 407 SWGKTYGEHKSHLEFSDTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSG 586
+ E + +L + E GI F+ + + D + L+ PF+
Sbjct: 57 ---SEMHRKRKEWELPVSFLPQLKQSCDEYGIQFSCTPFYL---DAVAELE-PFVDFYKI 109
Query: 587 DSNNLLF---LKYAASKKIPLIISTGMVD----KTAVKTIYDIISSDHKQFCLLHCISAY 745
S LL+ L P++IS GM A+KT+ + +SD LLHC+SAY
Sbjct: 110 ASYELLWDDLLAACVKTGKPVVISAGMATIEEIDHALKTLKENGASD---ITLLHCVSAY 166
Query: 746 P 748
P
Sbjct: 167 P 167
>UniRef50_UPI0000F219ED Cluster: PREDICTED: hypothetical protein;
n=1; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 100
Score = 37.5 bits (83), Expect = 0.37
Identities = 15/36 (41%), Positives = 24/36 (66%)
Frame = +2
Query: 521 MDMVSFDFLVNLKVPFIKIGSGDSNNLLFLKYAASK 628
MD ++ +FL + VPF K+ S D+NN+ +L+ A K
Sbjct: 1 MDEMAVEFLHEINVPFFKVASADTNNIPYLEKTAKK 36
>UniRef50_Q319P5 Cluster: Putative spore coat polysaccharide
biosynthesis protein E; n=1; Prochlorococcus marinus
str. MIT 9312|Rep: Putative spore coat polysaccharide
biosynthesis protein E - Prochlorococcus marinus (strain
MIT 9312)
Length = 521
Score = 35.9 bits (79), Expect = 1.1
Identities = 24/102 (23%), Positives = 41/102 (40%), Gaps = 1/102 (0%)
Frame = +2
Query: 455 DTQYRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNNLLFLKYAASKKI 634
D Q+ ++ ++ G + D S + + KI S L+ A++
Sbjct: 88 DEQWLQILNMVRDKGFKTIVTPFDEASVNKAERFGIEEYKIASCSCTEWSLLREVANQNK 147
Query: 635 PLIISTGMVDKTAVKTIYDIISSDHK-QFCLLHCISAYPGAI 757
P+ ISTG + V IY + +F ++HC YP I
Sbjct: 148 PVTISTGGRNLKEVDDIYSYFAHRIPYKFTIMHCCGIYPAPI 189
>UniRef50_Q8RI47 Cluster: Tetratricopeptide repeat family protein;
n=1; Fusobacterium nucleatum subsp. nucleatum|Rep:
Tetratricopeptide repeat family protein - Fusobacterium
nucleatum subsp. nucleatum
Length = 628
Score = 34.3 bits (75), Expect = 3.4
Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 1/76 (1%)
Frame = +2
Query: 488 QEVGILFTASA-MDMVSFDFLVNLKVPFIKIGSGDSNNLLFLKYAASKKIPLIISTGMVD 664
+E+GI +T S D+++ + NL FIK+ SG+ Y K M+D
Sbjct: 548 EEIGIFYTPSGKQDIINNKY--NLPEDFIKLKSGEIKTFFIDWYNNKTKEKFYELFNMID 605
Query: 665 KTAVKTIYDIISSDHK 712
KT++K ++++ K
Sbjct: 606 KTSIKVYLKYLNTEKK 621
>UniRef50_A5IGD9 Cluster: Spore coat polysaccharide biosynthesis
protein E; n=5; Legionella pneumophila|Rep: Spore coat
polysaccharide biosynthesis protein E - Legionella
pneumophila (strain Corby)
Length = 368
Score = 33.9 bits (74), Expect = 4.6
Identities = 21/96 (21%), Positives = 42/96 (43%), Gaps = 1/96 (1%)
Frame = +2
Query: 464 YRELFRYAQEVGILFTASAMDMVSFDFLVNLKVPFIKIGSGDSNNLLFLKYAASKKIPLI 643
Y LF + + F S ++ + DF + +K S + ++ +++ A +PLI
Sbjct: 107 YSMLFSLLKNANLPFIVSIYELDTIDFAIKQGACALKTSSSNIVHIPLIRHLAKTGLPLI 166
Query: 644 ISTGMVDKTAV-KTIYDIISSDHKQFCLLHCISAYP 748
I TG T + K + S+ ++ + H +P
Sbjct: 167 IDTGRSSLTDICKAVETAKSAGCEKIIIEHSPDGHP 202
>UniRef50_Q5A950 Cluster: Sterol 3-beta-glucosyltransferase; n=2;
Candida albicans|Rep: Sterol 3-beta-glucosyltransferase -
Candida albicans (Yeast)
Length = 1513
Score = 33.9 bits (74), Expect = 4.6
Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 4/68 (5%)
Frame = +2
Query: 338 FQKTCLG--EKFTKKYLERPYDNPNSWGKTYGE--HKSHLEFSDTQYRELFRYAQEVGIL 505
FQK L E+ K RP P WG + +K+ +E+SD++ RE+ +Y + I
Sbjct: 912 FQKVVLSVLERLHSKEGFRP--EPYQWGSNFEVELYKTRMEYSDSENREIQQYDNSIDIK 969
Query: 506 FTASAMDM 529
F ++M
Sbjct: 970 FAEKKIEM 977
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 774,597,278
Number of Sequences: 1657284
Number of extensions: 15377680
Number of successful extensions: 36879
Number of sequences better than 10.0: 85
Number of HSP's better than 10.0 without gapping: 35606
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 36779
length of database: 575,637,011
effective HSP length: 99
effective length of database: 411,565,895
effective search space used: 65438977305
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
- SilkBase 1999-2023 -