Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fmgV17d21r
(884 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC101829-1|AAI01830.1| 469|Homo sapiens cytosolic beta-glucosid... 178 2e-44
AF323990-1|AAL37305.1| 469|Homo sapiens cytosolic beta-glucosid... 178 2e-44
AF317840-1|AAG39217.1| 469|Homo sapiens cytosolic beta-glucosid... 178 2e-44
AB017913-1|BAB18741.1| 469|Homo sapiens cytosolic beta-glucosid... 178 2e-44
AJ278964-1|CAC08178.1| 469|Homo sapiens cytosolic beta-glucosid... 177 6e-44
M61850-1|AAA59504.1| 1927|Homo sapiens lactase phlorizinhydrolas... 176 1e-43
X07994-1|CAA30801.1| 1927|Homo sapiens protein ( Human mRNA for ... 175 1e-43
AC011893-3|AAX88924.1| 1927|Homo sapiens unknown protein. 175 1e-43
AK222963-1|BAD96683.1| 469|Homo sapiens cytosolic beta-glucosid... 174 3e-43
AY358729-1|AAQ89091.1| 567|Homo sapiens KPVW3022 protein. 147 5e-35
AY191611-1|AAP12677.1| 1003|Homo sapiens lactase-phlorizin hydro... 145 2e-34
BC113653-1|AAI13654.1| 1044|Homo sapiens klotho beta protein. 90 9e-18
BC104871-1|AAI04872.1| 1044|Homo sapiens klotho beta protein. 90 9e-18
AB079373-1|BAC56857.1| 1044|Homo sapiens klotho beta like protei... 90 9e-18
BC109377-1|AAI09378.1| 162|Homo sapiens GBA3 protein protein. 77 1e-13
BC070188-1|AAH70188.1| 162|Homo sapiens GBA3 protein protein. 77 1e-13
BC029362-1|AAH29362.1| 162|Homo sapiens GBA3 protein protein. 77 1e-13
Z84483-1|CAC94773.1| 739|Homo sapiens 46H23.1 (Klotho) protein. 76 2e-13
AL161898-1|CAH71888.1| 1012|Homo sapiens klotho protein. 76 2e-13
AB009667-2|BAA24941.1| 549|Homo sapiens Klotho protein (KL) pro... 76 2e-13
AB009667-1|BAA24940.1| 1012|Homo sapiens Klotho protein (KL) pro... 76 2e-13
AB005142-1|BAA23382.1| 1012|Homo sapiens klotho protein. 76 2e-13
BC033021-1|AAH33021.1| 305|Homo sapiens KLB protein protein. 66 2e-10
CR456790-1|CAG33071.1| 537|Homo sapiens CPNE1 protein. 31 5.6
U83246-1|AAC15920.1| 537|Homo sapiens copine I protein. 31 7.3
BC001142-1|AAH01142.1| 537|Homo sapiens copine I protein. 31 7.3
AL109827-11|CAI20122.1| 386|Homo sapiens copine I protein. 31 7.3
AL109827-10|CAO72111.1| 481|Homo sapiens copine I protein. 31 7.3
AL109827-9|CAB87610.2| 537|Homo sapiens copine I protein. 31 7.3
AB209827-1|BAD93064.1| 517|Homo sapiens copine I variant protein. 31 7.3
AB209169-1|BAD92406.1| 208|Homo sapiens growth differentiation ... 30 9.7
>BC101829-1|AAI01830.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 178 bits (433), Expect = 2e-44
Identities = 84/237 (35%), Positives = 140/237 (59%), Gaps = 1/237 (0%)
Frame = -3
Query: 792 DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEE 613
+S D+ AA+ ++ PIF +G +P+ + +++A S + GYP +RLP+ +EEE
Sbjct: 235 NSVSDQEAAKRAITFHLDLFAKPIFI-DGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEE 293
Query: 612 RVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLM 433
+ +I+GTADFF V +YT L+ ++ + + + D + + P W W+ ++
Sbjct: 294 KKMIKGTADFFAVQYYTTRLIKYQEN--KKGELGILQDAEIEFFPDPSWKN--VDWIYVV 349
Query: 432 PNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-V 256
P + +L ++K+ YN+P+ Y+TENG+ S L+D R Y+R + + ++ V
Sbjct: 350 PWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKV 409
Query: 255 RLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 85
L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 410 NLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 466
>AF323990-1|AAL37305.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 178 bits (433), Expect = 2e-44
Identities = 84/237 (35%), Positives = 140/237 (59%), Gaps = 1/237 (0%)
Frame = -3
Query: 792 DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEE 613
+S D+ AA+ ++ PIF +G +P+ + +++A S + GYP +RLP+ +EEE
Sbjct: 235 NSVSDQEAAKRAITFHLDLFAKPIFI-DGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEE 293
Query: 612 RVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLM 433
+ +I+GTADFF V +YT L+ ++ + + + D + + P W W+ ++
Sbjct: 294 KKMIKGTADFFAVQYYTTRLIKYQEN--KKGELGILQDAEIEFFPDPSWKN--VDWIYVV 349
Query: 432 PNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-V 256
P + +L ++K+ YN+P+ Y+TENG+ S L+D R Y+R + + ++ V
Sbjct: 350 PWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKV 409
Query: 255 RLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 85
L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 410 NLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 466
>AF317840-1|AAG39217.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 178 bits (433), Expect = 2e-44
Identities = 84/237 (35%), Positives = 140/237 (59%), Gaps = 1/237 (0%)
Frame = -3
Query: 792 DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEE 613
+S D+ AA+ ++ PIF +G +P+ + +++A S + GYP +RLP+ +EEE
Sbjct: 235 NSVSDQEAAKRAITFHLDLFAKPIFI-DGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEE 293
Query: 612 RVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLM 433
+ +I+GTADFF V +YT L+ ++ + + + D + + P W W+ ++
Sbjct: 294 KKMIKGTADFFAVQYYTTRLIKYQEN--KKGELGILQDAEIEFFPDPSWKN--VDWIYVV 349
Query: 432 PNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-V 256
P + +L ++K+ YN+P+ Y+TENG+ S L+D R Y+R + + ++ V
Sbjct: 350 PWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKV 409
Query: 255 RLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 85
L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 410 NLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 466
>AB017913-1|BAB18741.1| 469|Homo sapiens cytosolic
beta-glucosidase-like protein-1 protein.
Length = 469
Score = 178 bits (433), Expect = 2e-44
Identities = 84/237 (35%), Positives = 140/237 (59%), Gaps = 1/237 (0%)
Frame = -3
Query: 792 DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEE 613
+S D+ AA+ ++ PIF +G +P+ + +++A S + GYP +RLP+ +EEE
Sbjct: 235 NSVSDQEAAKRAITFHLDLFAKPIFI-DGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEE 293
Query: 612 RVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLM 433
+ +I+GTADFF V +YT L+ ++ + + + D + + P W W+ ++
Sbjct: 294 KKMIKGTADFFAVQYYTTRLIKYQEN--KKGELGILQDAEIEFFPDPSWKN--VDWIYVV 349
Query: 432 PNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-V 256
P + +L ++K+ YN+P+ Y+TENG+ S L+D R Y+R + + ++ V
Sbjct: 350 PWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKV 409
Query: 255 RLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 85
L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 410 NLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 466
>AJ278964-1|CAC08178.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 177 bits (430), Expect = 6e-44
Identities = 84/237 (35%), Positives = 139/237 (58%), Gaps = 1/237 (0%)
Frame = -3
Query: 792 DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEE 613
+S D+ AA+ ++ PIF +G +P+ + +++A S + GYP +RLP+ +EEE
Sbjct: 235 NSVSDQEAAKRAITFHLDLFAKPIFI-DGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEE 293
Query: 612 RVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLM 433
+ +I+GTADFF V +YT L+ ++ + + D + + P W W+ ++
Sbjct: 294 KKMIKGTADFFAVQYYTTRLIKYQEN--KKGELGTLQDAEIEFFPDPSWKN--VDWIYVV 349
Query: 432 PNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-V 256
P + +L ++K+ YN+P+ Y+TENG+ S L+D R Y+R + + ++ V
Sbjct: 350 PWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKV 409
Query: 255 RLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 85
L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 410 NLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 466
>M61850-1|AAA59504.1| 1927|Homo sapiens lactase phlorizinhydrolase
protein.
Length = 1927
Score = 176 bits (428), Expect = 1e-43
Identities = 95/250 (38%), Positives = 134/250 (53%), Gaps = 1/250 (0%)
Frame = -3
Query: 846 KGGQCGITFDVNSFKPLTDS-EEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAE 670
+GG IT + +P S +ED AA Q G + HPIF + G + + + R+ +
Sbjct: 1590 QGGVISITISSDWAEPRDPSNQEDVEAARRYVQFMGGWFAHPIF-KNGDYSEVMKTRIRD 1648
Query: 669 KSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINV 490
+S G ++RLP+ +E E+ I GT DFFG NHYT L + S S +D V
Sbjct: 1649 RSLAAGLNKSRLPEFTESEKRRINGTYDFFGFNHYTTVLAYNLNYATAIS--SFDADRGV 1706
Query: 489 GNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRI 310
+ W S + WL + P +L LK +YNDP YVTENG + E L D RI
Sbjct: 1707 ASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEYNDPPIYVTENGVSQREETDLNDTARI 1766
Query: 309 TYYRAALENILDSLDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 130
Y R + L ++ V L+GY WS MDN+EW G++ERFGL+ V++SDP+ PR P+
Sbjct: 1767 YYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKA 1826
Query: 129 SAFVYKEILR 100
SA Y ++R
Sbjct: 1827 SAKFYASVVR 1836
Score = 145 bits (351), Expect = 2e-34
Identities = 87/229 (37%), Positives = 122/229 (53%), Gaps = 3/229 (1%)
Frame = -3
Query: 780 DRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLI 601
D AA+ Q G + HPIF + G +P + +V +S +RLP +EEE+ I
Sbjct: 1139 DVEAADRMLQFSLGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFI 1197
Query: 600 RGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSI 421
R TAD F +N Y +V P + S D + P W +A + P
Sbjct: 1198 RATADVFCLNTYYSRIVQ--HKTPRLNPPSYEDDQEMAEEEDPSWPSTAMN--RAAPWGT 1253
Query: 420 YDVLTHLKNKYNDPIFYVTENGWA-TSPEVGLEDDDRITYYRAALENILDS--LDAGVRL 250
+L +K +Y D Y+TENG T+P ED DRI Y++ + L + LD G+ L
Sbjct: 1254 RRLLNWIKEEYGDIPIYITENGVGLTNPNT--EDTDRIFYHKTYINEALKAYRLD-GIDL 1310
Query: 249 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 103
+GY+AWSLMDN+EW+ GYT +FGLY VDF++ RPRT R SA Y E++
Sbjct: 1311 RGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVI 1359
Score = 140 bits (339), Expect = 6e-33
Identities = 83/255 (32%), Positives = 144/255 (56%), Gaps = 9/255 (3%)
Frame = -3
Query: 840 GQCGITFDVNSFKPLT-DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKS 664
G GI + + +PL+ + ED A+E G + HP+F +G +P L ++ + +
Sbjct: 595 GHVGIVLNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFV-DGDYPATLRTQIQQMN 653
Query: 663 AEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKH---IPEYSTVSLFSDIN 493
+ +P +LP+ +E E+ L++G+ADF G++HYT L+S IP Y T+ FS +
Sbjct: 654 RQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQ-H 712
Query: 492 VGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYND---PIFYVTENGWATSPEVGLED 322
V + W Q+++SW+ ++P I +L + +Y PI Y+ NG L D
Sbjct: 713 VNHV----WPQTSSSWIRVVPWGIRRLLQFVSLEYTRGKVPI-YLAGNGMPIGESENLFD 767
Query: 321 DD-RITYYRAALENILDSL-DAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPAR 148
D R+ Y+ + +L ++ + V ++ Y+A SL+D +E +GY++RFGL+ V+FSD ++
Sbjct: 768 DSLRVDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSK 827
Query: 147 PRTPRKSAFVYKEIL 103
RTPRKSA+ + I+
Sbjct: 828 SRTPRKSAYFFTSII 842
>X07994-1|CAA30801.1| 1927|Homo sapiens protein ( Human mRNA for
lactase-phlorizin hydrolase LPH (EC 3.2.1.23-62). ).
Length = 1927
Score = 175 bits (427), Expect = 1e-43
Identities = 95/250 (38%), Positives = 134/250 (53%), Gaps = 1/250 (0%)
Frame = -3
Query: 846 KGGQCGITFDVNSFKPLTDS-EEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAE 670
+GG IT + +P S +ED AA Q G + HPIF + G + + + R+ +
Sbjct: 1590 QGGVISITISSDWAEPRDPSNQEDVEAARRYVQFMGGWFAHPIF-KNGDYNEVMKTRIRD 1648
Query: 669 KSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINV 490
+S G ++RLP+ +E E+ I GT DFFG NHYT L + S S +D V
Sbjct: 1649 RSLAAGLNKSRLPEFTESEKRRINGTYDFFGFNHYTTVLAYNLNYATAIS--SFDADRGV 1706
Query: 489 GNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRI 310
+ W S + WL + P +L LK +YNDP YVTENG + E L D RI
Sbjct: 1707 ASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEYNDPPIYVTENGVSQREETDLNDTARI 1766
Query: 309 TYYRAALENILDSLDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 130
Y R + L ++ V L+GY WS MDN+EW G++ERFGL+ V++SDP+ PR P+
Sbjct: 1767 YYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKA 1826
Query: 129 SAFVYKEILR 100
SA Y ++R
Sbjct: 1827 SAKFYASVVR 1836
Score = 145 bits (351), Expect = 2e-34
Identities = 87/229 (37%), Positives = 122/229 (53%), Gaps = 3/229 (1%)
Frame = -3
Query: 780 DRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLI 601
D AA+ Q G + HPIF + G +P + +V +S +RLP +EEE+ I
Sbjct: 1139 DVEAADRMLQFSLGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFI 1197
Query: 600 RGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSI 421
R TAD F +N Y +V P + S D + P W +A + P
Sbjct: 1198 RATADVFCLNTYYSRIVQ--HKTPRLNPPSYEDDQEMAEEEDPSWPSTAMN--RAAPWGT 1253
Query: 420 YDVLTHLKNKYNDPIFYVTENGWA-TSPEVGLEDDDRITYYRAALENILDS--LDAGVRL 250
+L +K +Y D Y+TENG T+P ED DRI Y++ + L + LD G+ L
Sbjct: 1254 RRLLNWIKEEYGDIPIYITENGVGLTNPNT--EDTDRIFYHKTYINEALKAYRLD-GIDL 1310
Query: 249 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 103
+GY+AWSLMDN+EW+ GYT +FGLY VDF++ RPRT R SA Y E++
Sbjct: 1311 RGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVI 1359
Score = 140 bits (339), Expect = 6e-33
Identities = 83/255 (32%), Positives = 144/255 (56%), Gaps = 9/255 (3%)
Frame = -3
Query: 840 GQCGITFDVNSFKPLT-DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKS 664
G GI + + +PL+ + ED A+E G + HP+F +G +P L ++ + +
Sbjct: 595 GHVGIVLNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFV-DGDYPATLRTQIQQMN 653
Query: 663 AEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKH---IPEYSTVSLFSDIN 493
+ +P +LP+ +E E+ L++G+ADF G++HYT L+S IP Y T+ FS +
Sbjct: 654 RQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQ-H 712
Query: 492 VGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYND---PIFYVTENGWATSPEVGLED 322
V + W Q+++SW+ ++P I +L + +Y PI Y+ NG L D
Sbjct: 713 VNHV----WPQTSSSWIRVVPWGIRRLLQFVSLEYTRGKVPI-YLAGNGMPIGESENLFD 767
Query: 321 DD-RITYYRAALENILDSL-DAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPAR 148
D R+ Y+ + +L ++ + V ++ Y+A SL+D +E +GY++RFGL+ V+FSD ++
Sbjct: 768 DSLRVDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSK 827
Query: 147 PRTPRKSAFVYKEIL 103
RTPRKSA+ + I+
Sbjct: 828 SRTPRKSAYFFTSII 842
>AC011893-3|AAX88924.1| 1927|Homo sapiens unknown protein.
Length = 1927
Score = 175 bits (427), Expect = 1e-43
Identities = 95/250 (38%), Positives = 134/250 (53%), Gaps = 1/250 (0%)
Frame = -3
Query: 846 KGGQCGITFDVNSFKPLTDS-EEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAE 670
+GG IT + +P S +ED AA Q G + HPIF + G + + + R+ +
Sbjct: 1590 QGGVISITISSDWAEPRDPSNQEDVEAARRYVQFMGGWFAHPIF-KNGDYNEVMKTRIRD 1648
Query: 669 KSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINV 490
+S G ++RLP+ +E E+ I GT DFFG NHYT L + S S +D V
Sbjct: 1649 RSLAAGLNKSRLPEFTESEKRRINGTYDFFGFNHYTTVLAYNLNYATAIS--SFDADRGV 1706
Query: 489 GNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRI 310
+ W S + WL + P +L LK +YNDP YVTENG + E L D RI
Sbjct: 1707 ASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEYNDPPIYVTENGVSQREETDLNDTARI 1766
Query: 309 TYYRAALENILDSLDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 130
Y R + L ++ V L+GY WS MDN+EW G++ERFGL+ V++SDP+ PR P+
Sbjct: 1767 YYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKA 1826
Query: 129 SAFVYKEILR 100
SA Y ++R
Sbjct: 1827 SAKFYASVVR 1836
Score = 145 bits (351), Expect = 2e-34
Identities = 87/229 (37%), Positives = 122/229 (53%), Gaps = 3/229 (1%)
Frame = -3
Query: 780 DRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLI 601
D AA+ Q G + HPIF + G +P + +V +S +RLP +EEE+ I
Sbjct: 1139 DVEAADRMLQFSLGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFI 1197
Query: 600 RGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSI 421
R TAD F +N Y +V P + S D + P W +A + P
Sbjct: 1198 RATADVFCLNTYYSRIVQ--HKTPRLNPPSYEDDQEMAEEEDPSWPSTAMN--RAAPWGT 1253
Query: 420 YDVLTHLKNKYNDPIFYVTENGWA-TSPEVGLEDDDRITYYRAALENILDS--LDAGVRL 250
+L +K +Y D Y+TENG T+P ED DRI Y++ + L + LD G+ L
Sbjct: 1254 RRLLNWIKEEYGDIPIYITENGVGLTNPNT--EDTDRIFYHKTYINEALKAYRLD-GIDL 1310
Query: 249 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 103
+GY+AWSLMDN+EW+ GYT +FGLY VDF++ RPRT R SA Y E++
Sbjct: 1311 RGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVI 1359
Score = 140 bits (339), Expect = 6e-33
Identities = 83/255 (32%), Positives = 144/255 (56%), Gaps = 9/255 (3%)
Frame = -3
Query: 840 GQCGITFDVNSFKPLT-DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKS 664
G GI + + +PL+ + ED A+E G + HP+F +G +P L ++ + +
Sbjct: 595 GHVGIVLNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFV-DGDYPATLRTQIQQMN 653
Query: 663 AEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKH---IPEYSTVSLFSDIN 493
+ +P +LP+ +E E+ L++G+ADF G++HYT L+S IP Y T+ FS +
Sbjct: 654 RQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQ-H 712
Query: 492 VGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYND---PIFYVTENGWATSPEVGLED 322
V + W Q+++SW+ ++P I +L + +Y PI Y+ NG L D
Sbjct: 713 VNHV----WPQTSSSWIRVVPWGIRRLLQFVSLEYTRGKVPI-YLAGNGMPIGESENLFD 767
Query: 321 DD-RITYYRAALENILDSL-DAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPAR 148
D R+ Y+ + +L ++ + V ++ Y+A SL+D +E +GY++RFGL+ V+FSD ++
Sbjct: 768 DSLRVDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSK 827
Query: 147 PRTPRKSAFVYKEIL 103
RTPRKSA+ + I+
Sbjct: 828 SRTPRKSAYFFTSII 842
>AK222963-1|BAD96683.1| 469|Homo sapiens cytosolic beta-glucosidase
variant protein.
Length = 469
Score = 174 bits (424), Expect = 3e-43
Identities = 83/237 (35%), Positives = 139/237 (58%), Gaps = 1/237 (0%)
Frame = -3
Query: 792 DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEE 613
+S D+ AA+ ++ PIF +G +P+ + +++A S + GYP +RLP+ +EEE
Sbjct: 235 NSVSDQEAAKRAITFHLDLFAKPIFI-DGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEE 293
Query: 612 RVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLM 433
+ +I+GTADFF V + T L+ ++ + + + D + + P W W+ ++
Sbjct: 294 KKMIKGTADFFAVQYCTTRLIKYQEN--KRGELGILQDAEIEFFPDPSWKN--VDWIYVV 349
Query: 432 PNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-V 256
P + +L ++K+ YN+P+ Y+TENG+ S L+D R Y+R + + ++ V
Sbjct: 350 PWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKV 409
Query: 255 RLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 85
L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 410 NLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 466
>AY358729-1|AAQ89091.1| 567|Homo sapiens KPVW3022 protein.
Length = 567
Score = 147 bits (356), Expect = 5e-35
Identities = 81/248 (32%), Positives = 134/248 (54%), Gaps = 2/248 (0%)
Frame = -3
Query: 840 GQCGITFDVNSFKPLTDSE-EDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKS 664
G GI+ + + +P+ S +D AAE Q G + +PI++ G +P+ + + KS
Sbjct: 254 GLVGISLNCDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYA--GDYPQVMKDYIGRKS 311
Query: 663 AEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGN 484
AE G +RLP S +E+ I+GT+DF G+ H+T ++ ++ P S +D ++
Sbjct: 312 AEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRYITE-RNYPSRQGPSYQNDRDLIE 370
Query: 483 YRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPE-VGLEDDDRIT 307
P W + WL +P +L + +Y DP YV ENG + L D+ RI
Sbjct: 371 LVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQ 430
Query: 306 YYRAALENILDSLDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKS 127
Y + + +L ++ G +KGY +WSL+D +EW GY++R+G Y V+F+D +PR P+ S
Sbjct: 431 YLKGYINEMLKAIKDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKAS 490
Query: 126 AFVYKEIL 103
YK+I+
Sbjct: 491 VQYYKKII 498
>AY191611-1|AAP12677.1| 1003|Homo sapiens lactase-phlorizin
hydrolase-1 protein.
Length = 1003
Score = 145 bits (351), Expect = 2e-34
Identities = 87/229 (37%), Positives = 122/229 (53%), Gaps = 3/229 (1%)
Frame = -3
Query: 780 DRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLI 601
D AA+ Q G + HPIF + G +P + +V +S +RLP +EEE+ I
Sbjct: 571 DVEAADRMLQFSLGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFI 629
Query: 600 RGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSI 421
R TAD F +N Y +V P + S D + P W +A + P
Sbjct: 630 RATADVFCLNTYYSRIVQ--HKTPRLNPPSYEDDQEMAEEEDPSWPSTAMN--RAAPWGT 685
Query: 420 YDVLTHLKNKYNDPIFYVTENGWA-TSPEVGLEDDDRITYYRAALENILDS--LDAGVRL 250
+L +K +Y D Y+TENG T+P ED DRI Y++ + L + LD G+ L
Sbjct: 686 RRLLNWIKEEYGDIPIYITENGVGLTNPNT--EDTDRIFYHKTYINEALKAYRLD-GIDL 742
Query: 249 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 103
+GY+AWSLMDN+EW+ GYT +FGLY VDF++ RPRT R SA Y E++
Sbjct: 743 RGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVI 791
Score = 140 bits (339), Expect = 6e-33
Identities = 83/255 (32%), Positives = 144/255 (56%), Gaps = 9/255 (3%)
Frame = -3
Query: 840 GQCGITFDVNSFKPLT-DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKS 664
G GI + + +PL+ + ED A+E G + HP+F +G +P L ++ + +
Sbjct: 27 GHVGIVLNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFV-DGDYPATLRTQIQQMN 85
Query: 663 AEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKH---IPEYSTVSLFSDIN 493
+ +P +LP+ +E E+ L++G+ADF G++HYT L+S IP Y T+ FS +
Sbjct: 86 RQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQ-H 144
Query: 492 VGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYND---PIFYVTENGWATSPEVGLED 322
V + W Q+++SW+ ++P I +L + +Y PI Y+ NG L D
Sbjct: 145 VNHV----WPQTSSSWIRVVPWGIRRLLQFVSLEYTRGKVPI-YLAGNGMPIGESENLFD 199
Query: 321 DD-RITYYRAALENILDSL-DAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPAR 148
D R+ Y+ + +L ++ + V ++ Y+A SL+D +E +GY++RFGL+ V+FSD ++
Sbjct: 200 DSLRVDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSK 259
Query: 147 PRTPRKSAFVYKEIL 103
RTPRKSA+ + I+
Sbjct: 260 SRTPRKSAYFFTSII 274
>BC113653-1|AAI13654.1| 1044|Homo sapiens klotho beta protein.
Length = 1044
Score = 90.2 bits (214), Expect = 9e-18
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 1/110 (0%)
Frame = -3
Query: 426 SIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRL 250
++ + L +K +YN+P + ENGW T V ED I + L +L ++ +R+
Sbjct: 395 NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRV 454
Query: 249 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILR 100
GY AWSL+D +EW YT R GL+ VDF+ + R P+ SA YK+I+R
Sbjct: 455 FGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIR 504
Score = 66.5 bits (155), Expect = 1e-10
Identities = 60/215 (27%), Positives = 96/215 (44%), Gaps = 2/215 (0%)
Frame = -3
Query: 801 PLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLS 622
P DS A L+ + W + P+F + G +P + +A K G + LP+L+
Sbjct: 752 PYADSHWRAAERFLQFEIAW--FAEPLF-KTGDYPAAMREYIASKH-RRGLSSSALPRLT 807
Query: 621 EEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWL 442
E ER L++GT DF +NH+T V + E S + + S+ + L
Sbjct: 808 EAERRLLKGTVDFCALNHFTTRFV-----MHEQLAGSRYDSDRDIQFLQDITRLSSPTRL 862
Query: 441 TLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAA-LENILDS-L 268
++P + +L ++ Y D Y+T +G + LEDD YY L+ +L + L
Sbjct: 863 AVIPWGVRKLLRWVRRNYGDMDIYITASG---IDDQALEDDRLRKYYLGKYLQEVLKAYL 919
Query: 267 DAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDF 163
VR+KGY A+ L + RFG + DF
Sbjct: 920 IDKVRIKGYYAFKLAEEKS-----KPRFGFFTSDF 949
>BC104871-1|AAI04872.1| 1044|Homo sapiens klotho beta protein.
Length = 1044
Score = 90.2 bits (214), Expect = 9e-18
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 1/110 (0%)
Frame = -3
Query: 426 SIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRL 250
++ + L +K +YN+P + ENGW T V ED I + L +L ++ +R+
Sbjct: 395 NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRV 454
Query: 249 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILR 100
GY AWSL+D +EW YT R GL+ VDF+ + R P+ SA YK+I+R
Sbjct: 455 FGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIR 504
Score = 66.5 bits (155), Expect = 1e-10
Identities = 60/215 (27%), Positives = 96/215 (44%), Gaps = 2/215 (0%)
Frame = -3
Query: 801 PLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLS 622
P DS A L+ + W + P+F + G +P + +A K G + LP+L+
Sbjct: 752 PYADSHWRAAERFLQFEIAW--FAEPLF-KTGDYPAAMREYIASKH-RRGLSSSALPRLT 807
Query: 621 EEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWL 442
E ER L++GT DF +NH+T V + E S + + S+ + L
Sbjct: 808 EAERRLLKGTVDFCALNHFTTRFV-----MHEQLAGSRYDSDRDIQFLQDITRLSSPTRL 862
Query: 441 TLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAA-LENILDS-L 268
++P + +L ++ Y D Y+T +G + LEDD YY L+ +L + L
Sbjct: 863 AVIPWGVRKLLRWVRRNYGDMDIYITASG---IDDQALEDDRLRKYYLGKYLQEVLKAYL 919
Query: 267 DAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDF 163
VR+KGY A+ L + RFG + DF
Sbjct: 920 IDKVRIKGYYAFKLAEEKS-----KPRFGFFTSDF 949
>AB079373-1|BAC56857.1| 1044|Homo sapiens klotho beta like protein
protein.
Length = 1044
Score = 90.2 bits (214), Expect = 9e-18
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 1/110 (0%)
Frame = -3
Query: 426 SIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRL 250
++ + L +K +YN+P + ENGW T V ED I + L +L ++ +R+
Sbjct: 395 NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRV 454
Query: 249 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILR 100
GY AWSL+D +EW YT R GL+ VDF+ + R P+ SA YK+I+R
Sbjct: 455 FGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIR 504
Score = 66.5 bits (155), Expect = 1e-10
Identities = 60/215 (27%), Positives = 96/215 (44%), Gaps = 2/215 (0%)
Frame = -3
Query: 801 PLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLS 622
P DS A L+ + W + P+F + G +P + +A K G + LP+L+
Sbjct: 752 PYADSHWRAAERFLQFEIAW--FAEPLF-KTGDYPAAMREYIASKH-RRGLSSSALPRLT 807
Query: 621 EEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWL 442
E ER L++GT DF +NH+T V + E S + + S+ + L
Sbjct: 808 EAERRLLKGTVDFCALNHFTTRFV-----MHEQLAGSRYDSDRDIQFLQDITRLSSPTRL 862
Query: 441 TLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAA-LENILDS-L 268
++P + +L ++ Y D Y+T +G + LEDD YY L+ +L + L
Sbjct: 863 AVIPWGVRKLLRWVRRNYGDMDIYITASG---IDDQALEDDRLRKYYLGKYLQEVLKAYL 919
Query: 267 DAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDF 163
VR+KGY A+ L + RFG + DF
Sbjct: 920 IDKVRIKGYYAFKLAEEKS-----KPRFGFFTSDF 949
>BC109377-1|AAI09378.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 76.6 bits (180), Expect = 1e-13
Identities = 32/58 (55%), Positives = 42/58 (72%)
Frame = -3
Query: 258 VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 85
V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 102 VNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 159
>BC070188-1|AAH70188.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 76.6 bits (180), Expect = 1e-13
Identities = 32/58 (55%), Positives = 42/58 (72%)
Frame = -3
Query: 258 VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 85
V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 102 VNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 159
>BC029362-1|AAH29362.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 76.6 bits (180), Expect = 1e-13
Identities = 32/58 (55%), Positives = 42/58 (72%)
Frame = -3
Query: 258 VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 85
V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 102 VNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 159
>Z84483-1|CAC94773.1| 739|Homo sapiens 46H23.1 (Klotho) protein.
Length = 739
Score = 75.8 bits (178), Expect = 2e-13
Identities = 64/249 (25%), Positives = 104/249 (41%), Gaps = 1/249 (0%)
Frame = -3
Query: 846 KGGQCGITFDVNSFKPLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEK 667
+GGQ I + P ++ + G + P+F +G +P+ + ++
Sbjct: 17 QGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFI-DGDYPESMKNNLS-- 73
Query: 666 SAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVG 487
+ LP +E E+ I+GTADFF A P S L +
Sbjct: 74 --------SILPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFR 114
Query: 486 NYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRIT 307
P L+ SW+ L ++N P ++ ENGW S +D +
Sbjct: 115 QLESPN-LRQLLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMY 159
Query: 306 YYRAALENILDSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 130
Y + + L ++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+
Sbjct: 160 YLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKS 219
Query: 129 SAFVYKEIL 103
SA Y++++
Sbjct: 220 SALFYQKLI 228
Score = 70.9 bits (166), Expect = 6e-12
Identities = 72/254 (28%), Positives = 113/254 (44%), Gaps = 4/254 (1%)
Frame = -3
Query: 846 KGGQCGITFDVNSFKPLTD-SEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAE 670
+ G+ I + +P S++D+ AE + + G PIF G +P + + +
Sbjct: 449 QNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGS-GDYPWVMRDWLNQ 507
Query: 669 KSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINV 490
++ LP +E+E+ LI+GT DF ++HYT LV + K P + + V
Sbjct: 508 RN------NFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDP----IKYNDYLEV 557
Query: 489 GNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDD-R 313
WL S S + ++P + VL LK KY D Y+ NG + EDD R
Sbjct: 558 QEMTDITWLNS-PSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNG--IDDGLHAEDDQLR 614
Query: 312 ITYYRAALENILDS--LDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRT 139
+ Y + + L + LD G+ L GY A+S D RFGLY +D P+
Sbjct: 615 VYYMQNYINEALKAHILD-GINLCGYFAYSFNDR------TAPRFGLYRY-AADQFEPKA 666
Query: 138 PRKSAFVYKEILRS 97
K Y++I+ S
Sbjct: 667 SMKH---YRKIIDS 677
>AL161898-1|CAH71888.1| 1012|Homo sapiens klotho protein.
Length = 1012
Score = 75.8 bits (178), Expect = 2e-13
Identities = 64/249 (25%), Positives = 104/249 (41%), Gaps = 1/249 (0%)
Frame = -3
Query: 846 KGGQCGITFDVNSFKPLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEK 667
+GGQ I + P ++ + G + P+F +G +P+ + ++
Sbjct: 290 QGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFI-DGDYPESMKNNLS-- 346
Query: 666 SAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVG 487
+ LP +E E+ I+GTADFF A P S L +
Sbjct: 347 --------SILPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFR 387
Query: 486 NYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRIT 307
P L+ SW+ L ++N P ++ ENGW S +D +
Sbjct: 388 QLESPN-LRQLLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMY 432
Query: 306 YYRAALENILDSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 130
Y + + L ++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+
Sbjct: 433 YLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKS 492
Query: 129 SAFVYKEIL 103
SA Y++++
Sbjct: 493 SALFYQKLI 501
Score = 70.9 bits (166), Expect = 6e-12
Identities = 72/254 (28%), Positives = 113/254 (44%), Gaps = 4/254 (1%)
Frame = -3
Query: 846 KGGQCGITFDVNSFKPLTD-SEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAE 670
+ G+ I + +P S++D+ AE + + G PIF G +P + + +
Sbjct: 722 QNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGS-GDYPWVMRDWLNQ 780
Query: 669 KSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINV 490
++ LP +E+E+ LI+GT DF ++HYT LV + K P + + V
Sbjct: 781 RN------NFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDP----IKYNDYLEV 830
Query: 489 GNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDD-R 313
WL S S + ++P + VL LK KY D Y+ NG + EDD R
Sbjct: 831 QEMTDITWLNS-PSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNG--IDDGLHAEDDQLR 887
Query: 312 ITYYRAALENILDS--LDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRT 139
+ Y + + L + LD G+ L GY A+S D RFGLY +D P+
Sbjct: 888 VYYMQNYINEALKAHILD-GINLCGYFAYSFNDR------TAPRFGLYRY-AADQFEPKA 939
Query: 138 PRKSAFVYKEILRS 97
K Y++I+ S
Sbjct: 940 SMKH---YRKIIDS 950
>AB009667-2|BAA24941.1| 549|Homo sapiens Klotho protein (KL)
protein.
Length = 549
Score = 75.8 bits (178), Expect = 2e-13
Identities = 64/249 (25%), Positives = 104/249 (41%), Gaps = 1/249 (0%)
Frame = -3
Query: 846 KGGQCGITFDVNSFKPLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEK 667
+GGQ I + P ++ + G + P+F +G +P+ + ++
Sbjct: 290 QGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFI-DGDYPESMKNNLS-- 346
Query: 666 SAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVG 487
+ LP +E E+ I+GTADFF A P S L +
Sbjct: 347 --------SILPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFR 387
Query: 486 NYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRIT 307
P L+ SW+ L ++N P ++ ENGW S +D +
Sbjct: 388 QLESPN-LRQLLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMY 432
Query: 306 YYRAALENILDSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 130
Y + + L ++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+
Sbjct: 433 YLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKS 492
Query: 129 SAFVYKEIL 103
SA Y++++
Sbjct: 493 SALFYQKLI 501
>AB009667-1|BAA24940.1| 1012|Homo sapiens Klotho protein (KL)
protein.
Length = 1012
Score = 75.8 bits (178), Expect = 2e-13
Identities = 64/249 (25%), Positives = 104/249 (41%), Gaps = 1/249 (0%)
Frame = -3
Query: 846 KGGQCGITFDVNSFKPLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEK 667
+GGQ I + P ++ + G + P+F +G +P+ + ++
Sbjct: 290 QGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFI-DGDYPESMKNNLS-- 346
Query: 666 SAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVG 487
+ LP +E E+ I+GTADFF A P S L +
Sbjct: 347 --------SILPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFR 387
Query: 486 NYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRIT 307
P L+ SW+ L ++N P ++ ENGW S +D +
Sbjct: 388 QLESPN-LRQLLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMY 432
Query: 306 YYRAALENILDSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 130
Y + + L ++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+
Sbjct: 433 YLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKS 492
Query: 129 SAFVYKEIL 103
SA Y++++
Sbjct: 493 SALFYQKLI 501
Score = 70.9 bits (166), Expect = 6e-12
Identities = 72/254 (28%), Positives = 113/254 (44%), Gaps = 4/254 (1%)
Frame = -3
Query: 846 KGGQCGITFDVNSFKPLTD-SEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAE 670
+ G+ I + +P S++D+ AE + + G PIF G +P + + +
Sbjct: 722 QNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGS-GDYPWVMRDWLNQ 780
Query: 669 KSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINV 490
++ LP +E+E+ LI+GT DF ++HYT LV + K P + + V
Sbjct: 781 RN------NFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDP----IKYNDYLEV 830
Query: 489 GNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDD-R 313
WL S S + ++P + VL LK KY D Y+ NG + EDD R
Sbjct: 831 QEMTDITWLNS-PSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNG--IDDGLHAEDDQLR 887
Query: 312 ITYYRAALENILDS--LDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRT 139
+ Y + + L + LD G+ L GY A+S D RFGLY +D P+
Sbjct: 888 VYYMQNYINEALKAHILD-GINLCGYFAYSFNDR------TAPRFGLYRY-AADQFEPKA 939
Query: 138 PRKSAFVYKEILRS 97
K Y++I+ S
Sbjct: 940 SMKH---YRKIIDS 950
>AB005142-1|BAA23382.1| 1012|Homo sapiens klotho protein.
Length = 1012
Score = 75.8 bits (178), Expect = 2e-13
Identities = 64/249 (25%), Positives = 104/249 (41%), Gaps = 1/249 (0%)
Frame = -3
Query: 846 KGGQCGITFDVNSFKPLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEK 667
+GGQ I + P ++ + G + P+F +G +P+ + ++
Sbjct: 290 QGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFI-DGDYPESMKNNLS-- 346
Query: 666 SAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVG 487
+ LP +E E+ I+GTADFF A P S L +
Sbjct: 347 --------SILPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFR 387
Query: 486 NYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRIT 307
P L+ SW+ L ++N P ++ ENGW S +D +
Sbjct: 388 QLESPN-LRQLLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMY 432
Query: 306 YYRAALENILDSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 130
Y + + L ++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+
Sbjct: 433 YLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKS 492
Query: 129 SAFVYKEIL 103
SA Y++++
Sbjct: 493 SALFYQKLI 501
Score = 70.9 bits (166), Expect = 6e-12
Identities = 72/254 (28%), Positives = 113/254 (44%), Gaps = 4/254 (1%)
Frame = -3
Query: 846 KGGQCGITFDVNSFKPLTD-SEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAE 670
+ G+ I + +P S++D+ AE + + G PIF G +P + + +
Sbjct: 722 QNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGS-GDYPWVMRDWLNQ 780
Query: 669 KSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINV 490
++ LP +E+E+ LI+GT DF ++HYT LV + K P + + V
Sbjct: 781 RN------NFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDP----IKYNDYLEV 830
Query: 489 GNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDD-R 313
WL S S + ++P + VL LK KY D Y+ NG + EDD R
Sbjct: 831 QEMTDITWLNS-PSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNG--IDDGLHAEDDQLR 887
Query: 312 ITYYRAALENILDS--LDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRT 139
+ Y + + L + LD G+ L GY A+S D RFGLY +D P+
Sbjct: 888 VYYMQNYINEALKAHILD-GINLCGYFAYSFNDR------TAPRFGLYRY-AADQFEPKA 939
Query: 138 PRKSAFVYKEILRS 97
K Y++I+ S
Sbjct: 940 SMKH---YRKIIDS 950
>BC033021-1|AAH33021.1| 305|Homo sapiens KLB protein protein.
Length = 305
Score = 66.1 bits (154), Expect = 2e-10
Identities = 59/205 (28%), Positives = 93/205 (45%), Gaps = 2/205 (0%)
Frame = -3
Query: 771 AAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGT 592
AAE Q E + P+F + G +P + +A K G + LP+L+E ER L++GT
Sbjct: 21 AAERFLQFEIAWFAEPLF-KTGDYPAAMREYIASKH-RRGLSSSALPRLTEAERRLLKGT 78
Query: 591 ADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDV 412
DF +NH+T V + E S + + S+ + L ++P + +
Sbjct: 79 VDFCALNHFTTRFV-----MHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKL 133
Query: 411 LTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAA-LENILDS-LDAGVRLKGYM 238
L ++ Y D Y+T +G + LEDD YY L+ +L + L VR+KGY
Sbjct: 134 LRWVRRNYGDMDIYITASG---IDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYY 190
Query: 237 AWSLMDNYEWMAGYTERFGLYEVDF 163
A+ L + RFG + DF
Sbjct: 191 AFKLAEEKS-----KPRFGFFTSDF 210
>CR456790-1|CAG33071.1| 537|Homo sapiens CPNE1 protein.
Length = 537
Score = 31.1 bits (67), Expect = 5.6
Identities = 18/56 (32%), Positives = 24/56 (42%)
Frame = -3
Query: 579 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDV 412
GVN Y L S + +Y + LF G PP+W S L P++ Y V
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPYCV 367
>U83246-1|AAC15920.1| 537|Homo sapiens copine I protein.
Length = 537
Score = 30.7 bits (66), Expect = 7.3
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -3
Query: 579 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 418
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 365
>BC001142-1|AAH01142.1| 537|Homo sapiens copine I protein.
Length = 537
Score = 30.7 bits (66), Expect = 7.3
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -3
Query: 579 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 418
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 365
>AL109827-11|CAI20122.1| 386|Homo sapiens copine I protein.
Length = 386
Score = 30.7 bits (66), Expect = 7.3
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -3
Query: 579 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 418
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 288 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 341
>AL109827-10|CAO72111.1| 481|Homo sapiens copine I protein.
Length = 481
Score = 30.7 bits (66), Expect = 7.3
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -3
Query: 579 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 418
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 365
>AL109827-9|CAB87610.2| 537|Homo sapiens copine I protein.
Length = 537
Score = 30.7 bits (66), Expect = 7.3
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -3
Query: 579 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 418
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 365
>AB209827-1|BAD93064.1| 517|Homo sapiens copine I variant protein.
Length = 517
Score = 30.7 bits (66), Expect = 7.3
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -3
Query: 579 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 418
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 292 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 345
>AB209169-1|BAD92406.1| 208|Homo sapiens growth differentiation
factor 1 variant protein.
Length = 208
Score = 30.3 bits (65), Expect = 9.7
Identities = 14/25 (56%), Positives = 16/25 (64%), Gaps = 1/25 (4%)
Frame = -2
Query: 151 PPSHPAQV-RVRLQGDLEEQGHRPR 80
PP HPA + R R G L +GHRPR
Sbjct: 71 PPPHPASISRPRPPGPLPLRGHRPR 95
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 131,820,707
Number of Sequences: 237096
Number of extensions: 2908753
Number of successful extensions: 10592
Number of sequences better than 10.0: 31
Number of HSP's better than 10.0 without gapping: 10324
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 10540
length of database: 76,859,062
effective HSP length: 90
effective length of database: 55,520,422
effective search space used: 11326166088
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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