Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fmgV16m22r
(858 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC101829-1|AAI01830.1| 469|Homo sapiens cytosolic beta-glucosid... 179 1e-44
AF323990-1|AAL37305.1| 469|Homo sapiens cytosolic beta-glucosid... 179 1e-44
AF317840-1|AAG39217.1| 469|Homo sapiens cytosolic beta-glucosid... 179 1e-44
AB017913-1|BAB18741.1| 469|Homo sapiens cytosolic beta-glucosid... 179 1e-44
M61850-1|AAA59504.1| 1927|Homo sapiens lactase phlorizinhydrolas... 177 3e-44
AJ278964-1|CAC08178.1| 469|Homo sapiens cytosolic beta-glucosid... 177 3e-44
X07994-1|CAA30801.1| 1927|Homo sapiens protein ( Human mRNA for ... 177 4e-44
AC011893-3|AAX88924.1| 1927|Homo sapiens unknown protein. 177 4e-44
AK222963-1|BAD96683.1| 469|Homo sapiens cytosolic beta-glucosid... 175 2e-43
AY358729-1|AAQ89091.1| 567|Homo sapiens KPVW3022 protein. 150 6e-36
AY191611-1|AAP12677.1| 1003|Homo sapiens lactase-phlorizin hydro... 145 2e-34
BC113653-1|AAI13654.1| 1044|Homo sapiens klotho beta protein. 90 8e-18
BC104871-1|AAI04872.1| 1044|Homo sapiens klotho beta protein. 90 8e-18
AB079373-1|BAC56857.1| 1044|Homo sapiens klotho beta like protei... 90 8e-18
Z84483-1|CAC94773.1| 739|Homo sapiens 46H23.1 (Klotho) protein. 77 6e-14
AL161898-1|CAH71888.1| 1012|Homo sapiens klotho protein. 77 6e-14
AB009667-2|BAA24941.1| 549|Homo sapiens Klotho protein (KL) pro... 77 6e-14
AB009667-1|BAA24940.1| 1012|Homo sapiens Klotho protein (KL) pro... 77 6e-14
AB005142-1|BAA23382.1| 1012|Homo sapiens klotho protein. 77 6e-14
BC109377-1|AAI09378.1| 162|Homo sapiens GBA3 protein protein. 77 1e-13
BC070188-1|AAH70188.1| 162|Homo sapiens GBA3 protein protein. 77 1e-13
BC029362-1|AAH29362.1| 162|Homo sapiens GBA3 protein protein. 77 1e-13
BC033021-1|AAH33021.1| 305|Homo sapiens KLB protein protein. 66 2e-10
CR456790-1|CAG33071.1| 537|Homo sapiens CPNE1 protein. 31 5.4
U83246-1|AAC15920.1| 537|Homo sapiens copine I protein. 31 7.1
BC001142-1|AAH01142.1| 537|Homo sapiens copine I protein. 31 7.1
AL109827-11|CAI20122.1| 386|Homo sapiens copine I protein. 31 7.1
AL109827-10|CAO72111.1| 481|Homo sapiens copine I protein. 31 7.1
AL109827-9|CAB87610.2| 537|Homo sapiens copine I protein. 31 7.1
AB209827-1|BAD93064.1| 517|Homo sapiens copine I variant protein. 31 7.1
AB209169-1|BAD92406.1| 208|Homo sapiens growth differentiation ... 30 9.4
>BC101829-1|AAI01830.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 179 bits (435), Expect = 1e-44
Identities = 88/257 (34%), Positives = 147/257 (57%), Gaps = 2/257 (0%)
Frame = -1
Query: 858 KQGGQCGITFDVNSFKPLT-DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVA 682
KQ G ++ +P +S D+ AA+ ++ PIF +G +P+ + +++A
Sbjct: 215 KQKGMVSLSLFAVWLEPADPNSVSDQEAAKRAITFHLDLFAKPIFI-DGDYPEVVKSQIA 273
Query: 681 EKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDIN 502
S + GYP +RLP+ +EEE+ +I+GTADFF V +YT L+ ++ + + + D
Sbjct: 274 SMSQKQGYPSSRLPEFTEEEKKMIKGTADFFAVQYYTTRLIKYQEN--KKGELGILQDAE 331
Query: 501 VGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDR 322
+ + P W W+ ++P + +L ++K+ YN+P+ Y+TENG+ S L+D R
Sbjct: 332 IEFFPDPSWKN--VDWIYVVPWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQR 389
Query: 321 ITYYRAALENILDSLDAG-VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTP 145
Y+R + + ++ V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P
Sbjct: 390 WEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVP 449
Query: 144 RKSAFVYKEILRSRVID 94
SA Y +I+R+ ++
Sbjct: 450 YTSAKEYAKIIRNNGLE 466
>AF323990-1|AAL37305.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 179 bits (435), Expect = 1e-44
Identities = 88/257 (34%), Positives = 147/257 (57%), Gaps = 2/257 (0%)
Frame = -1
Query: 858 KQGGQCGITFDVNSFKPLT-DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVA 682
KQ G ++ +P +S D+ AA+ ++ PIF +G +P+ + +++A
Sbjct: 215 KQKGMVSLSLFAVWLEPADPNSVSDQEAAKRAITFHLDLFAKPIFI-DGDYPEVVKSQIA 273
Query: 681 EKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDIN 502
S + GYP +RLP+ +EEE+ +I+GTADFF V +YT L+ ++ + + + D
Sbjct: 274 SMSQKQGYPSSRLPEFTEEEKKMIKGTADFFAVQYYTTRLIKYQEN--KKGELGILQDAE 331
Query: 501 VGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDR 322
+ + P W W+ ++P + +L ++K+ YN+P+ Y+TENG+ S L+D R
Sbjct: 332 IEFFPDPSWKN--VDWIYVVPWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQR 389
Query: 321 ITYYRAALENILDSLDAG-VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTP 145
Y+R + + ++ V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P
Sbjct: 390 WEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVP 449
Query: 144 RKSAFVYKEILRSRVID 94
SA Y +I+R+ ++
Sbjct: 450 YTSAKEYAKIIRNNGLE 466
>AF317840-1|AAG39217.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 179 bits (435), Expect = 1e-44
Identities = 88/257 (34%), Positives = 147/257 (57%), Gaps = 2/257 (0%)
Frame = -1
Query: 858 KQGGQCGITFDVNSFKPLT-DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVA 682
KQ G ++ +P +S D+ AA+ ++ PIF +G +P+ + +++A
Sbjct: 215 KQKGMVSLSLFAVWLEPADPNSVSDQEAAKRAITFHLDLFAKPIFI-DGDYPEVVKSQIA 273
Query: 681 EKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDIN 502
S + GYP +RLP+ +EEE+ +I+GTADFF V +YT L+ ++ + + + D
Sbjct: 274 SMSQKQGYPSSRLPEFTEEEKKMIKGTADFFAVQYYTTRLIKYQEN--KKGELGILQDAE 331
Query: 501 VGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDR 322
+ + P W W+ ++P + +L ++K+ YN+P+ Y+TENG+ S L+D R
Sbjct: 332 IEFFPDPSWKN--VDWIYVVPWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQR 389
Query: 321 ITYYRAALENILDSLDAG-VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTP 145
Y+R + + ++ V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P
Sbjct: 390 WEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVP 449
Query: 144 RKSAFVYKEILRSRVID 94
SA Y +I+R+ ++
Sbjct: 450 YTSAKEYAKIIRNNGLE 466
>AB017913-1|BAB18741.1| 469|Homo sapiens cytosolic
beta-glucosidase-like protein-1 protein.
Length = 469
Score = 179 bits (435), Expect = 1e-44
Identities = 88/257 (34%), Positives = 147/257 (57%), Gaps = 2/257 (0%)
Frame = -1
Query: 858 KQGGQCGITFDVNSFKPLT-DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVA 682
KQ G ++ +P +S D+ AA+ ++ PIF +G +P+ + +++A
Sbjct: 215 KQKGMVSLSLFAVWLEPADPNSVSDQEAAKRAITFHLDLFAKPIFI-DGDYPEVVKSQIA 273
Query: 681 EKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDIN 502
S + GYP +RLP+ +EEE+ +I+GTADFF V +YT L+ ++ + + + D
Sbjct: 274 SMSQKQGYPSSRLPEFTEEEKKMIKGTADFFAVQYYTTRLIKYQEN--KKGELGILQDAE 331
Query: 501 VGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDR 322
+ + P W W+ ++P + +L ++K+ YN+P+ Y+TENG+ S L+D R
Sbjct: 332 IEFFPDPSWKN--VDWIYVVPWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQR 389
Query: 321 ITYYRAALENILDSLDAG-VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTP 145
Y+R + + ++ V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P
Sbjct: 390 WEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVP 449
Query: 144 RKSAFVYKEILRSRVID 94
SA Y +I+R+ ++
Sbjct: 450 YTSAKEYAKIIRNNGLE 466
>M61850-1|AAA59504.1| 1927|Homo sapiens lactase phlorizinhydrolase
protein.
Length = 1927
Score = 177 bits (432), Expect = 3e-44
Identities = 96/250 (38%), Positives = 134/250 (53%), Gaps = 1/250 (0%)
Frame = -1
Query: 855 QGGQCGITFDVNSFKPLTDS-EEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAE 679
QGG IT + +P S +ED AA Q G + HPIF + G + + + R+ +
Sbjct: 1590 QGGVISITISSDWAEPRDPSNQEDVEAARRYVQFMGGWFAHPIF-KNGDYSEVMKTRIRD 1648
Query: 678 KSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINV 499
+S G ++RLP+ +E E+ I GT DFFG NHYT L + S S +D V
Sbjct: 1649 RSLAAGLNKSRLPEFTESEKRRINGTYDFFGFNHYTTVLAYNLNYATAIS--SFDADRGV 1706
Query: 498 GNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRI 319
+ W S + WL + P +L LK +YNDP YVTENG + E L D RI
Sbjct: 1707 ASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEYNDPPIYVTENGVSQREETDLNDTARI 1766
Query: 318 TYYRAALENILDSLDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 139
Y R + L ++ V L+GY WS MDN+EW G++ERFGL+ V++SDP+ PR P+
Sbjct: 1767 YYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKA 1826
Query: 138 SAFVYKEILR 109
SA Y ++R
Sbjct: 1827 SAKFYASVVR 1836
Score = 145 bits (351), Expect = 2e-34
Identities = 87/229 (37%), Positives = 122/229 (53%), Gaps = 3/229 (1%)
Frame = -1
Query: 789 DRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLI 610
D AA+ Q G + HPIF + G +P + +V +S +RLP +EEE+ I
Sbjct: 1139 DVEAADRMLQFSLGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFI 1197
Query: 609 RGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSI 430
R TAD F +N Y +V P + S D + P W +A + P
Sbjct: 1198 RATADVFCLNTYYSRIVQ--HKTPRLNPPSYEDDQEMAEEEDPSWPSTAMN--RAAPWGT 1253
Query: 429 YDVLTHLKNKYNDPIFYVTENGWA-TSPEVGLEDDDRITYYRAALENILDS--LDAGVRL 259
+L +K +Y D Y+TENG T+P ED DRI Y++ + L + LD G+ L
Sbjct: 1254 RRLLNWIKEEYGDIPIYITENGVGLTNPNT--EDTDRIFYHKTYINEALKAYRLD-GIDL 1310
Query: 258 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 112
+GY+AWSLMDN+EW+ GYT +FGLY VDF++ RPRT R SA Y E++
Sbjct: 1311 RGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVI 1359
Score = 142 bits (343), Expect = 2e-33
Identities = 84/258 (32%), Positives = 146/258 (56%), Gaps = 9/258 (3%)
Frame = -1
Query: 858 KQGGQCGITFDVNSFKPLT-DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVA 682
+Q G GI + + +PL+ + ED A+E G + HP+F +G +P L ++
Sbjct: 592 QQQGHVGIVLNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFV-DGDYPATLRTQIQ 650
Query: 681 EKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKH---IPEYSTVSLFS 511
+ + + +P +LP+ +E E+ L++G+ADF G++HYT L+S IP Y T+ FS
Sbjct: 651 QMNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFS 710
Query: 510 DINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYND---PIFYVTENGWATSPEVG 340
+V + W Q+++SW+ ++P I +L + +Y PI Y+ NG
Sbjct: 711 Q-HVNHV----WPQTSSSWIRVVPWGIRRLLQFVSLEYTRGKVPI-YLAGNGMPIGESEN 764
Query: 339 LEDDD-RITYYRAALENILDSL-DAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSD 166
L DD R+ Y+ + +L ++ + V ++ Y+A SL+D +E +GY++RFGL+ V+FSD
Sbjct: 765 LFDDSLRVDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSD 824
Query: 165 PARPRTPRKSAFVYKEIL 112
++ RTPRKSA+ + I+
Sbjct: 825 SSKSRTPRKSAYFFTSII 842
>AJ278964-1|CAC08178.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 177 bits (432), Expect = 3e-44
Identities = 88/257 (34%), Positives = 146/257 (56%), Gaps = 2/257 (0%)
Frame = -1
Query: 858 KQGGQCGITFDVNSFKPLT-DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVA 682
KQ G ++ +P +S D+ AA+ ++ PIF +G +P+ + +++A
Sbjct: 215 KQKGMVSLSLFAVWLEPADPNSVSDQEAAKRAITFHLDLFAKPIFI-DGDYPEVVKSQIA 273
Query: 681 EKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDIN 502
S + GYP +RLP+ +EEE+ +I+GTADFF V +YT L+ ++ + + D
Sbjct: 274 SMSQKQGYPSSRLPEFTEEEKKMIKGTADFFAVQYYTTRLIKYQEN--KKGELGTLQDAE 331
Query: 501 VGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDR 322
+ + P W W+ ++P + +L ++K+ YN+P+ Y+TENG+ S L+D R
Sbjct: 332 IEFFPDPSWKN--VDWIYVVPWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQR 389
Query: 321 ITYYRAALENILDSLDAG-VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTP 145
Y+R + + ++ V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P
Sbjct: 390 WEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVP 449
Query: 144 RKSAFVYKEILRSRVID 94
SA Y +I+R+ ++
Sbjct: 450 YTSAKEYAKIIRNNGLE 466
>X07994-1|CAA30801.1| 1927|Homo sapiens protein ( Human mRNA for
lactase-phlorizin hydrolase LPH (EC 3.2.1.23-62). ).
Length = 1927
Score = 177 bits (431), Expect = 4e-44
Identities = 96/250 (38%), Positives = 134/250 (53%), Gaps = 1/250 (0%)
Frame = -1
Query: 855 QGGQCGITFDVNSFKPLTDS-EEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAE 679
QGG IT + +P S +ED AA Q G + HPIF + G + + + R+ +
Sbjct: 1590 QGGVISITISSDWAEPRDPSNQEDVEAARRYVQFMGGWFAHPIF-KNGDYNEVMKTRIRD 1648
Query: 678 KSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINV 499
+S G ++RLP+ +E E+ I GT DFFG NHYT L + S S +D V
Sbjct: 1649 RSLAAGLNKSRLPEFTESEKRRINGTYDFFGFNHYTTVLAYNLNYATAIS--SFDADRGV 1706
Query: 498 GNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRI 319
+ W S + WL + P +L LK +YNDP YVTENG + E L D RI
Sbjct: 1707 ASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEYNDPPIYVTENGVSQREETDLNDTARI 1766
Query: 318 TYYRAALENILDSLDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 139
Y R + L ++ V L+GY WS MDN+EW G++ERFGL+ V++SDP+ PR P+
Sbjct: 1767 YYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKA 1826
Query: 138 SAFVYKEILR 109
SA Y ++R
Sbjct: 1827 SAKFYASVVR 1836
Score = 145 bits (351), Expect = 2e-34
Identities = 87/229 (37%), Positives = 122/229 (53%), Gaps = 3/229 (1%)
Frame = -1
Query: 789 DRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLI 610
D AA+ Q G + HPIF + G +P + +V +S +RLP +EEE+ I
Sbjct: 1139 DVEAADRMLQFSLGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFI 1197
Query: 609 RGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSI 430
R TAD F +N Y +V P + S D + P W +A + P
Sbjct: 1198 RATADVFCLNTYYSRIVQ--HKTPRLNPPSYEDDQEMAEEEDPSWPSTAMN--RAAPWGT 1253
Query: 429 YDVLTHLKNKYNDPIFYVTENGWA-TSPEVGLEDDDRITYYRAALENILDS--LDAGVRL 259
+L +K +Y D Y+TENG T+P ED DRI Y++ + L + LD G+ L
Sbjct: 1254 RRLLNWIKEEYGDIPIYITENGVGLTNPNT--EDTDRIFYHKTYINEALKAYRLD-GIDL 1310
Query: 258 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 112
+GY+AWSLMDN+EW+ GYT +FGLY VDF++ RPRT R SA Y E++
Sbjct: 1311 RGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVI 1359
Score = 142 bits (343), Expect = 2e-33
Identities = 84/258 (32%), Positives = 146/258 (56%), Gaps = 9/258 (3%)
Frame = -1
Query: 858 KQGGQCGITFDVNSFKPLT-DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVA 682
+Q G GI + + +PL+ + ED A+E G + HP+F +G +P L ++
Sbjct: 592 QQQGHVGIVLNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFV-DGDYPATLRTQIQ 650
Query: 681 EKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKH---IPEYSTVSLFS 511
+ + + +P +LP+ +E E+ L++G+ADF G++HYT L+S IP Y T+ FS
Sbjct: 651 QMNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFS 710
Query: 510 DINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYND---PIFYVTENGWATSPEVG 340
+V + W Q+++SW+ ++P I +L + +Y PI Y+ NG
Sbjct: 711 Q-HVNHV----WPQTSSSWIRVVPWGIRRLLQFVSLEYTRGKVPI-YLAGNGMPIGESEN 764
Query: 339 LEDDD-RITYYRAALENILDSL-DAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSD 166
L DD R+ Y+ + +L ++ + V ++ Y+A SL+D +E +GY++RFGL+ V+FSD
Sbjct: 765 LFDDSLRVDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSD 824
Query: 165 PARPRTPRKSAFVYKEIL 112
++ RTPRKSA+ + I+
Sbjct: 825 SSKSRTPRKSAYFFTSII 842
>AC011893-3|AAX88924.1| 1927|Homo sapiens unknown protein.
Length = 1927
Score = 177 bits (431), Expect = 4e-44
Identities = 96/250 (38%), Positives = 134/250 (53%), Gaps = 1/250 (0%)
Frame = -1
Query: 855 QGGQCGITFDVNSFKPLTDS-EEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAE 679
QGG IT + +P S +ED AA Q G + HPIF + G + + + R+ +
Sbjct: 1590 QGGVISITISSDWAEPRDPSNQEDVEAARRYVQFMGGWFAHPIF-KNGDYNEVMKTRIRD 1648
Query: 678 KSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINV 499
+S G ++RLP+ +E E+ I GT DFFG NHYT L + S S +D V
Sbjct: 1649 RSLAAGLNKSRLPEFTESEKRRINGTYDFFGFNHYTTVLAYNLNYATAIS--SFDADRGV 1706
Query: 498 GNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRI 319
+ W S + WL + P +L LK +YNDP YVTENG + E L D RI
Sbjct: 1707 ASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEYNDPPIYVTENGVSQREETDLNDTARI 1766
Query: 318 TYYRAALENILDSLDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 139
Y R + L ++ V L+GY WS MDN+EW G++ERFGL+ V++SDP+ PR P+
Sbjct: 1767 YYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKA 1826
Query: 138 SAFVYKEILR 109
SA Y ++R
Sbjct: 1827 SAKFYASVVR 1836
Score = 145 bits (351), Expect = 2e-34
Identities = 87/229 (37%), Positives = 122/229 (53%), Gaps = 3/229 (1%)
Frame = -1
Query: 789 DRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLI 610
D AA+ Q G + HPIF + G +P + +V +S +RLP +EEE+ I
Sbjct: 1139 DVEAADRMLQFSLGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFI 1197
Query: 609 RGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSI 430
R TAD F +N Y +V P + S D + P W +A + P
Sbjct: 1198 RATADVFCLNTYYSRIVQ--HKTPRLNPPSYEDDQEMAEEEDPSWPSTAMN--RAAPWGT 1253
Query: 429 YDVLTHLKNKYNDPIFYVTENGWA-TSPEVGLEDDDRITYYRAALENILDS--LDAGVRL 259
+L +K +Y D Y+TENG T+P ED DRI Y++ + L + LD G+ L
Sbjct: 1254 RRLLNWIKEEYGDIPIYITENGVGLTNPNT--EDTDRIFYHKTYINEALKAYRLD-GIDL 1310
Query: 258 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 112
+GY+AWSLMDN+EW+ GYT +FGLY VDF++ RPRT R SA Y E++
Sbjct: 1311 RGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVI 1359
Score = 142 bits (343), Expect = 2e-33
Identities = 84/258 (32%), Positives = 146/258 (56%), Gaps = 9/258 (3%)
Frame = -1
Query: 858 KQGGQCGITFDVNSFKPLT-DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVA 682
+Q G GI + + +PL+ + ED A+E G + HP+F +G +P L ++
Sbjct: 592 QQQGHVGIVLNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFV-DGDYPATLRTQIQ 650
Query: 681 EKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKH---IPEYSTVSLFS 511
+ + + +P +LP+ +E E+ L++G+ADF G++HYT L+S IP Y T+ FS
Sbjct: 651 QMNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFS 710
Query: 510 DINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYND---PIFYVTENGWATSPEVG 340
+V + W Q+++SW+ ++P I +L + +Y PI Y+ NG
Sbjct: 711 Q-HVNHV----WPQTSSSWIRVVPWGIRRLLQFVSLEYTRGKVPI-YLAGNGMPIGESEN 764
Query: 339 LEDDD-RITYYRAALENILDSL-DAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSD 166
L DD R+ Y+ + +L ++ + V ++ Y+A SL+D +E +GY++RFGL+ V+FSD
Sbjct: 765 LFDDSLRVDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSD 824
Query: 165 PARPRTPRKSAFVYKEIL 112
++ RTPRKSA+ + I+
Sbjct: 825 SSKSRTPRKSAYFFTSII 842
>AK222963-1|BAD96683.1| 469|Homo sapiens cytosolic beta-glucosidase
variant protein.
Length = 469
Score = 175 bits (426), Expect = 2e-43
Identities = 87/257 (33%), Positives = 146/257 (56%), Gaps = 2/257 (0%)
Frame = -1
Query: 858 KQGGQCGITFDVNSFKPLT-DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVA 682
KQ G ++ +P +S D+ AA+ ++ PIF +G +P+ + +++A
Sbjct: 215 KQKGMVSLSLFAVWLEPADPNSVSDQEAAKRAITFHLDLFAKPIFI-DGDYPEVVKSQIA 273
Query: 681 EKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDIN 502
S + GYP +RLP+ +EEE+ +I+GTADFF V + T L+ ++ + + + D
Sbjct: 274 SMSQKQGYPSSRLPEFTEEEKKMIKGTADFFAVQYCTTRLIKYQEN--KRGELGILQDAE 331
Query: 501 VGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDR 322
+ + P W W+ ++P + +L ++K+ YN+P+ Y+TENG+ S L+D R
Sbjct: 332 IEFFPDPSWKN--VDWIYVVPWGVCKLLKYIKDTYNNPVIYITENGFPQSDPAPLDDTQR 389
Query: 321 ITYYRAALENILDSLDAG-VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTP 145
Y+R + + ++ V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P
Sbjct: 390 WEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVP 449
Query: 144 RKSAFVYKEILRSRVID 94
SA Y +I+R+ ++
Sbjct: 450 YTSAKEYAKIIRNNGLE 466
>AY358729-1|AAQ89091.1| 567|Homo sapiens KPVW3022 protein.
Length = 567
Score = 150 bits (364), Expect = 6e-36
Identities = 83/251 (33%), Positives = 136/251 (54%), Gaps = 2/251 (0%)
Frame = -1
Query: 858 KQGGQCGITFDVNSFKPLTDSE-EDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVA 682
KQ G GI+ + + +P+ S +D AAE Q G + +PI++ G +P+ + +
Sbjct: 251 KQQGLVGISLNCDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYA--GDYPQVMKDYIG 308
Query: 681 EKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDIN 502
KSAE G +RLP S +E+ I+GT+DF G+ H+T ++ ++ P S +D +
Sbjct: 309 RKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRYITE-RNYPSRQGPSYQNDRD 367
Query: 501 VGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPE-VGLEDDD 325
+ P W + WL +P +L + +Y DP YV ENG + L D+
Sbjct: 368 LIELVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEW 427
Query: 324 RITYYRAALENILDSLDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTP 145
RI Y + + +L ++ G +KGY +WSL+D +EW GY++R+G Y V+F+D +PR P
Sbjct: 428 RIQYLKGYINEMLKAIKDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYP 487
Query: 144 RKSAFVYKEIL 112
+ S YK+I+
Sbjct: 488 KASVQYYKKII 498
>AY191611-1|AAP12677.1| 1003|Homo sapiens lactase-phlorizin
hydrolase-1 protein.
Length = 1003
Score = 145 bits (351), Expect = 2e-34
Identities = 87/229 (37%), Positives = 122/229 (53%), Gaps = 3/229 (1%)
Frame = -1
Query: 789 DRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLI 610
D AA+ Q G + HPIF + G +P + +V +S +RLP +EEE+ I
Sbjct: 571 DVEAADRMLQFSLGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFI 629
Query: 609 RGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSI 430
R TAD F +N Y +V P + S D + P W +A + P
Sbjct: 630 RATADVFCLNTYYSRIVQ--HKTPRLNPPSYEDDQEMAEEEDPSWPSTAMN--RAAPWGT 685
Query: 429 YDVLTHLKNKYNDPIFYVTENGWA-TSPEVGLEDDDRITYYRAALENILDS--LDAGVRL 259
+L +K +Y D Y+TENG T+P ED DRI Y++ + L + LD G+ L
Sbjct: 686 RRLLNWIKEEYGDIPIYITENGVGLTNPNT--EDTDRIFYHKTYINEALKAYRLD-GIDL 742
Query: 258 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 112
+GY+AWSLMDN+EW+ GYT +FGLY VDF++ RPRT R SA Y E++
Sbjct: 743 RGYVAWSLMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVI 791
Score = 142 bits (343), Expect = 2e-33
Identities = 84/258 (32%), Positives = 146/258 (56%), Gaps = 9/258 (3%)
Frame = -1
Query: 858 KQGGQCGITFDVNSFKPLT-DSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVA 682
+Q G GI + + +PL+ + ED A+E G + HP+F +G +P L ++
Sbjct: 24 QQQGHVGIVLNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFV-DGDYPATLRTQIQ 82
Query: 681 EKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKH---IPEYSTVSLFS 511
+ + + +P +LP+ +E E+ L++G+ADF G++HYT L+S IP Y T+ FS
Sbjct: 83 QMNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFS 142
Query: 510 DINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYND---PIFYVTENGWATSPEVG 340
+V + W Q+++SW+ ++P I +L + +Y PI Y+ NG
Sbjct: 143 Q-HVNHV----WPQTSSSWIRVVPWGIRRLLQFVSLEYTRGKVPI-YLAGNGMPIGESEN 196
Query: 339 LEDDD-RITYYRAALENILDSL-DAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSD 166
L DD R+ Y+ + +L ++ + V ++ Y+A SL+D +E +GY++RFGL+ V+FSD
Sbjct: 197 LFDDSLRVDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSD 256
Query: 165 PARPRTPRKSAFVYKEIL 112
++ RTPRKSA+ + I+
Sbjct: 257 SSKSRTPRKSAYFFTSII 274
>BC113653-1|AAI13654.1| 1044|Homo sapiens klotho beta protein.
Length = 1044
Score = 90.2 bits (214), Expect = 8e-18
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 1/110 (0%)
Frame = -1
Query: 435 SIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRL 259
++ + L +K +YN+P + ENGW T V ED I + L +L ++ +R+
Sbjct: 395 NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRV 454
Query: 258 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILR 109
GY AWSL+D +EW YT R GL+ VDF+ + R P+ SA YK+I+R
Sbjct: 455 FGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIR 504
Score = 66.5 bits (155), Expect = 1e-10
Identities = 60/215 (27%), Positives = 96/215 (44%), Gaps = 2/215 (0%)
Frame = -1
Query: 810 PLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLS 631
P DS A L+ + W + P+F + G +P + +A K G + LP+L+
Sbjct: 752 PYADSHWRAAERFLQFEIAW--FAEPLF-KTGDYPAAMREYIASKH-RRGLSSSALPRLT 807
Query: 630 EEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWL 451
E ER L++GT DF +NH+T V + E S + + S+ + L
Sbjct: 808 EAERRLLKGTVDFCALNHFTTRFV-----MHEQLAGSRYDSDRDIQFLQDITRLSSPTRL 862
Query: 450 TLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAA-LENILDS-L 277
++P + +L ++ Y D Y+T +G + LEDD YY L+ +L + L
Sbjct: 863 AVIPWGVRKLLRWVRRNYGDMDIYITASG---IDDQALEDDRLRKYYLGKYLQEVLKAYL 919
Query: 276 DAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDF 172
VR+KGY A+ L + RFG + DF
Sbjct: 920 IDKVRIKGYYAFKLAEEKS-----KPRFGFFTSDF 949
>BC104871-1|AAI04872.1| 1044|Homo sapiens klotho beta protein.
Length = 1044
Score = 90.2 bits (214), Expect = 8e-18
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 1/110 (0%)
Frame = -1
Query: 435 SIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRL 259
++ + L +K +YN+P + ENGW T V ED I + L +L ++ +R+
Sbjct: 395 NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRV 454
Query: 258 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILR 109
GY AWSL+D +EW YT R GL+ VDF+ + R P+ SA YK+I+R
Sbjct: 455 FGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIR 504
Score = 66.5 bits (155), Expect = 1e-10
Identities = 60/215 (27%), Positives = 96/215 (44%), Gaps = 2/215 (0%)
Frame = -1
Query: 810 PLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLS 631
P DS A L+ + W + P+F + G +P + +A K G + LP+L+
Sbjct: 752 PYADSHWRAAERFLQFEIAW--FAEPLF-KTGDYPAAMREYIASKH-RRGLSSSALPRLT 807
Query: 630 EEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWL 451
E ER L++GT DF +NH+T V + E S + + S+ + L
Sbjct: 808 EAERRLLKGTVDFCALNHFTTRFV-----MHEQLAGSRYDSDRDIQFLQDITRLSSPTRL 862
Query: 450 TLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAA-LENILDS-L 277
++P + +L ++ Y D Y+T +G + LEDD YY L+ +L + L
Sbjct: 863 AVIPWGVRKLLRWVRRNYGDMDIYITASG---IDDQALEDDRLRKYYLGKYLQEVLKAYL 919
Query: 276 DAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDF 172
VR+KGY A+ L + RFG + DF
Sbjct: 920 IDKVRIKGYYAFKLAEEKS-----KPRFGFFTSDF 949
>AB079373-1|BAC56857.1| 1044|Homo sapiens klotho beta like protein
protein.
Length = 1044
Score = 90.2 bits (214), Expect = 8e-18
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 1/110 (0%)
Frame = -1
Query: 435 SIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRL 259
++ + L +K +YN+P + ENGW T V ED I + L +L ++ +R+
Sbjct: 395 NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRV 454
Query: 258 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILR 109
GY AWSL+D +EW YT R GL+ VDF+ + R P+ SA YK+I+R
Sbjct: 455 FGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIR 504
Score = 66.5 bits (155), Expect = 1e-10
Identities = 60/215 (27%), Positives = 96/215 (44%), Gaps = 2/215 (0%)
Frame = -1
Query: 810 PLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLS 631
P DS A L+ + W + P+F + G +P + +A K G + LP+L+
Sbjct: 752 PYADSHWRAAERFLQFEIAW--FAEPLF-KTGDYPAAMREYIASKH-RRGLSSSALPRLT 807
Query: 630 EEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWL 451
E ER L++GT DF +NH+T V + E S + + S+ + L
Sbjct: 808 EAERRLLKGTVDFCALNHFTTRFV-----MHEQLAGSRYDSDRDIQFLQDITRLSSPTRL 862
Query: 450 TLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAA-LENILDS-L 277
++P + +L ++ Y D Y+T +G + LEDD YY L+ +L + L
Sbjct: 863 AVIPWGVRKLLRWVRRNYGDMDIYITASG---IDDQALEDDRLRKYYLGKYLQEVLKAYL 919
Query: 276 DAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDF 172
VR+KGY A+ L + RFG + DF
Sbjct: 920 IDKVRIKGYYAFKLAEEKS-----KPRFGFFTSDF 949
>Z84483-1|CAC94773.1| 739|Homo sapiens 46H23.1 (Klotho) protein.
Length = 739
Score = 77.4 bits (182), Expect = 6e-14
Identities = 65/249 (26%), Positives = 104/249 (41%), Gaps = 1/249 (0%)
Frame = -1
Query: 855 QGGQCGITFDVNSFKPLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEK 676
QGGQ I + P ++ + G + P+F +G +P+ + ++
Sbjct: 17 QGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFI-DGDYPESMKNNLS-- 73
Query: 675 SAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVG 496
+ LP +E E+ I+GTADFF A P S L +
Sbjct: 74 --------SILPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFR 114
Query: 495 NYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRIT 316
P L+ SW+ L ++N P ++ ENGW S +D +
Sbjct: 115 QLESPN-LRQLLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMY 159
Query: 315 YYRAALENILDSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 139
Y + + L ++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+
Sbjct: 160 YLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKS 219
Query: 138 SAFVYKEIL 112
SA Y++++
Sbjct: 220 SALFYQKLI 228
Score = 72.5 bits (170), Expect = 2e-12
Identities = 73/254 (28%), Positives = 113/254 (44%), Gaps = 4/254 (1%)
Frame = -1
Query: 855 QGGQCGITFDVNSFKPLTD-SEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAE 679
Q G+ I + +P S++D+ AE + + G PIF G +P + + +
Sbjct: 449 QNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGS-GDYPWVMRDWLNQ 507
Query: 678 KSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINV 499
++ LP +E+E+ LI+GT DF ++HYT LV + K P + + V
Sbjct: 508 RN------NFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDP----IKYNDYLEV 557
Query: 498 GNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDD-R 322
WL S S + ++P + VL LK KY D Y+ NG + EDD R
Sbjct: 558 QEMTDITWLNS-PSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNG--IDDGLHAEDDQLR 614
Query: 321 ITYYRAALENILDS--LDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRT 148
+ Y + + L + LD G+ L GY A+S D RFGLY +D P+
Sbjct: 615 VYYMQNYINEALKAHILD-GINLCGYFAYSFNDR------TAPRFGLYRY-AADQFEPKA 666
Query: 147 PRKSAFVYKEILRS 106
K Y++I+ S
Sbjct: 667 SMKH---YRKIIDS 677
>AL161898-1|CAH71888.1| 1012|Homo sapiens klotho protein.
Length = 1012
Score = 77.4 bits (182), Expect = 6e-14
Identities = 65/249 (26%), Positives = 104/249 (41%), Gaps = 1/249 (0%)
Frame = -1
Query: 855 QGGQCGITFDVNSFKPLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEK 676
QGGQ I + P ++ + G + P+F +G +P+ + ++
Sbjct: 290 QGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFI-DGDYPESMKNNLS-- 346
Query: 675 SAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVG 496
+ LP +E E+ I+GTADFF A P S L +
Sbjct: 347 --------SILPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFR 387
Query: 495 NYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRIT 316
P L+ SW+ L ++N P ++ ENGW S +D +
Sbjct: 388 QLESPN-LRQLLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMY 432
Query: 315 YYRAALENILDSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 139
Y + + L ++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+
Sbjct: 433 YLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKS 492
Query: 138 SAFVYKEIL 112
SA Y++++
Sbjct: 493 SALFYQKLI 501
Score = 72.5 bits (170), Expect = 2e-12
Identities = 73/254 (28%), Positives = 113/254 (44%), Gaps = 4/254 (1%)
Frame = -1
Query: 855 QGGQCGITFDVNSFKPLTD-SEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAE 679
Q G+ I + +P S++D+ AE + + G PIF G +P + + +
Sbjct: 722 QNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGS-GDYPWVMRDWLNQ 780
Query: 678 KSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINV 499
++ LP +E+E+ LI+GT DF ++HYT LV + K P + + V
Sbjct: 781 RN------NFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDP----IKYNDYLEV 830
Query: 498 GNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDD-R 322
WL S S + ++P + VL LK KY D Y+ NG + EDD R
Sbjct: 831 QEMTDITWLNS-PSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNG--IDDGLHAEDDQLR 887
Query: 321 ITYYRAALENILDS--LDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRT 148
+ Y + + L + LD G+ L GY A+S D RFGLY +D P+
Sbjct: 888 VYYMQNYINEALKAHILD-GINLCGYFAYSFNDR------TAPRFGLYRY-AADQFEPKA 939
Query: 147 PRKSAFVYKEILRS 106
K Y++I+ S
Sbjct: 940 SMKH---YRKIIDS 950
>AB009667-2|BAA24941.1| 549|Homo sapiens Klotho protein (KL)
protein.
Length = 549
Score = 77.4 bits (182), Expect = 6e-14
Identities = 65/249 (26%), Positives = 104/249 (41%), Gaps = 1/249 (0%)
Frame = -1
Query: 855 QGGQCGITFDVNSFKPLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEK 676
QGGQ I + P ++ + G + P+F +G +P+ + ++
Sbjct: 290 QGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFI-DGDYPESMKNNLS-- 346
Query: 675 SAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVG 496
+ LP +E E+ I+GTADFF A P S L +
Sbjct: 347 --------SILPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFR 387
Query: 495 NYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRIT 316
P L+ SW+ L ++N P ++ ENGW S +D +
Sbjct: 388 QLESPN-LRQLLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMY 432
Query: 315 YYRAALENILDSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 139
Y + + L ++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+
Sbjct: 433 YLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKS 492
Query: 138 SAFVYKEIL 112
SA Y++++
Sbjct: 493 SALFYQKLI 501
>AB009667-1|BAA24940.1| 1012|Homo sapiens Klotho protein (KL)
protein.
Length = 1012
Score = 77.4 bits (182), Expect = 6e-14
Identities = 65/249 (26%), Positives = 104/249 (41%), Gaps = 1/249 (0%)
Frame = -1
Query: 855 QGGQCGITFDVNSFKPLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEK 676
QGGQ I + P ++ + G + P+F +G +P+ + ++
Sbjct: 290 QGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFI-DGDYPESMKNNLS-- 346
Query: 675 SAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVG 496
+ LP +E E+ I+GTADFF A P S L +
Sbjct: 347 --------SILPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFR 387
Query: 495 NYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRIT 316
P L+ SW+ L ++N P ++ ENGW S +D +
Sbjct: 388 QLESPN-LRQLLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMY 432
Query: 315 YYRAALENILDSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 139
Y + + L ++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+
Sbjct: 433 YLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKS 492
Query: 138 SAFVYKEIL 112
SA Y++++
Sbjct: 493 SALFYQKLI 501
Score = 72.5 bits (170), Expect = 2e-12
Identities = 73/254 (28%), Positives = 113/254 (44%), Gaps = 4/254 (1%)
Frame = -1
Query: 855 QGGQCGITFDVNSFKPLTD-SEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAE 679
Q G+ I + +P S++D+ AE + + G PIF G +P + + +
Sbjct: 722 QNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGS-GDYPWVMRDWLNQ 780
Query: 678 KSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINV 499
++ LP +E+E+ LI+GT DF ++HYT LV + K P + + V
Sbjct: 781 RN------NFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDP----IKYNDYLEV 830
Query: 498 GNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDD-R 322
WL S S + ++P + VL LK KY D Y+ NG + EDD R
Sbjct: 831 QEMTDITWLNS-PSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNG--IDDGLHAEDDQLR 887
Query: 321 ITYYRAALENILDS--LDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRT 148
+ Y + + L + LD G+ L GY A+S D RFGLY +D P+
Sbjct: 888 VYYMQNYINEALKAHILD-GINLCGYFAYSFNDR------TAPRFGLYRY-AADQFEPKA 939
Query: 147 PRKSAFVYKEILRS 106
K Y++I+ S
Sbjct: 940 SMKH---YRKIIDS 950
>AB005142-1|BAA23382.1| 1012|Homo sapiens klotho protein.
Length = 1012
Score = 77.4 bits (182), Expect = 6e-14
Identities = 65/249 (26%), Positives = 104/249 (41%), Gaps = 1/249 (0%)
Frame = -1
Query: 855 QGGQCGITFDVNSFKPLTDSEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEK 676
QGGQ I + P ++ + G + P+F +G +P+ + ++
Sbjct: 290 QGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFI-DGDYPESMKNNLS-- 346
Query: 675 SAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVG 496
+ LP +E E+ I+GTADFF A P S L +
Sbjct: 347 --------SILPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFR 387
Query: 495 NYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRIT 316
P L+ SW+ L ++N P ++ ENGW S +D +
Sbjct: 388 QLESPN-LRQLLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMY 432
Query: 315 YYRAALENILDSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRK 139
Y + + L ++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+
Sbjct: 433 YLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKS 492
Query: 138 SAFVYKEIL 112
SA Y++++
Sbjct: 493 SALFYQKLI 501
Score = 72.5 bits (170), Expect = 2e-12
Identities = 73/254 (28%), Positives = 113/254 (44%), Gaps = 4/254 (1%)
Frame = -1
Query: 855 QGGQCGITFDVNSFKPLTD-SEEDRAAAELKRQAEWGIYVHPIFSQEGGFPKELVARVAE 679
Q G+ I + +P S++D+ AE + + G PIF G +P + + +
Sbjct: 722 QNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGS-GDYPWVMRDWLNQ 780
Query: 678 KSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINV 499
++ LP +E+E+ LI+GT DF ++HYT LV + K P + + V
Sbjct: 781 RN------NFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDP----IKYNDYLEV 830
Query: 498 GNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDD-R 322
WL S S + ++P + VL LK KY D Y+ NG + EDD R
Sbjct: 831 QEMTDITWLNS-PSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNG--IDDGLHAEDDQLR 887
Query: 321 ITYYRAALENILDS--LDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRT 148
+ Y + + L + LD G+ L GY A+S D RFGLY +D P+
Sbjct: 888 VYYMQNYINEALKAHILD-GINLCGYFAYSFNDR------TAPRFGLYRY-AADQFEPKA 939
Query: 147 PRKSAFVYKEILRS 106
K Y++I+ S
Sbjct: 940 SMKH---YRKIIDS 950
>BC109377-1|AAI09378.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 76.6 bits (180), Expect = 1e-13
Identities = 32/58 (55%), Positives = 42/58 (72%)
Frame = -1
Query: 267 VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 94
V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 102 VNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 159
>BC070188-1|AAH70188.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 76.6 bits (180), Expect = 1e-13
Identities = 32/58 (55%), Positives = 42/58 (72%)
Frame = -1
Query: 267 VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 94
V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 102 VNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 159
>BC029362-1|AAH29362.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 76.6 bits (180), Expect = 1e-13
Identities = 32/58 (55%), Positives = 42/58 (72%)
Frame = -1
Query: 267 VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 94
V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 102 VNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 159
>BC033021-1|AAH33021.1| 305|Homo sapiens KLB protein protein.
Length = 305
Score = 66.1 bits (154), Expect = 2e-10
Identities = 59/205 (28%), Positives = 93/205 (45%), Gaps = 2/205 (0%)
Frame = -1
Query: 780 AAELKRQAEWGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGT 601
AAE Q E + P+F + G +P + +A K G + LP+L+E ER L++GT
Sbjct: 21 AAERFLQFEIAWFAEPLF-KTGDYPAAMREYIASKH-RRGLSSSALPRLTEAERRLLKGT 78
Query: 600 ADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDV 421
DF +NH+T V + E S + + S+ + L ++P + +
Sbjct: 79 VDFCALNHFTTRFV-----MHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKL 133
Query: 420 LTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAA-LENILDS-LDAGVRLKGYM 247
L ++ Y D Y+T +G + LEDD YY L+ +L + L VR+KGY
Sbjct: 134 LRWVRRNYGDMDIYITASG---IDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYY 190
Query: 246 AWSLMDNYEWMAGYTERFGLYEVDF 172
A+ L + RFG + DF
Sbjct: 191 AFKLAEEKS-----KPRFGFFTSDF 210
>CR456790-1|CAG33071.1| 537|Homo sapiens CPNE1 protein.
Length = 537
Score = 31.1 bits (67), Expect = 5.4
Identities = 18/56 (32%), Positives = 24/56 (42%)
Frame = -1
Query: 588 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDV 421
GVN Y L S + +Y + LF G PP+W S L P++ Y V
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPYCV 367
>U83246-1|AAC15920.1| 537|Homo sapiens copine I protein.
Length = 537
Score = 30.7 bits (66), Expect = 7.1
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -1
Query: 588 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 427
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 365
>BC001142-1|AAH01142.1| 537|Homo sapiens copine I protein.
Length = 537
Score = 30.7 bits (66), Expect = 7.1
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -1
Query: 588 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 427
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 365
>AL109827-11|CAI20122.1| 386|Homo sapiens copine I protein.
Length = 386
Score = 30.7 bits (66), Expect = 7.1
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -1
Query: 588 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 427
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 288 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 341
>AL109827-10|CAO72111.1| 481|Homo sapiens copine I protein.
Length = 481
Score = 30.7 bits (66), Expect = 7.1
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -1
Query: 588 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 427
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 365
>AL109827-9|CAB87610.2| 537|Homo sapiens copine I protein.
Length = 537
Score = 30.7 bits (66), Expect = 7.1
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -1
Query: 588 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 427
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 365
>AB209827-1|BAD93064.1| 517|Homo sapiens copine I variant protein.
Length = 517
Score = 30.7 bits (66), Expect = 7.1
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -1
Query: 588 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 427
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 292 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 345
>AB209169-1|BAD92406.1| 208|Homo sapiens growth differentiation
factor 1 variant protein.
Length = 208
Score = 30.3 bits (65), Expect = 9.4
Identities = 14/25 (56%), Positives = 16/25 (64%), Gaps = 1/25 (4%)
Frame = -3
Query: 160 PPSHPAQV-RVRLQGDLEEQGHRPR 89
PP HPA + R R G L +GHRPR
Sbjct: 71 PPPHPASISRPRPPGPLPLRGHRPR 95
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 129,638,495
Number of Sequences: 237096
Number of extensions: 2856893
Number of successful extensions: 10356
Number of sequences better than 10.0: 31
Number of HSP's better than 10.0 without gapping: 10114
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 10304
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 10928473528
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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