Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fmgV13m06r
(779 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC101829-1|AAI01830.1| 469|Homo sapiens cytosolic beta-glucosid... 177 5e-44
AF323990-1|AAL37305.1| 469|Homo sapiens cytosolic beta-glucosid... 177 5e-44
AF317840-1|AAG39217.1| 469|Homo sapiens cytosolic beta-glucosid... 177 5e-44
AB017913-1|BAB18741.1| 469|Homo sapiens cytosolic beta-glucosid... 177 5e-44
AJ278964-1|CAC08178.1| 469|Homo sapiens cytosolic beta-glucosid... 175 1e-43
AK222963-1|BAD96683.1| 469|Homo sapiens cytosolic beta-glucosid... 173 6e-43
M61850-1|AAA59504.1| 1927|Homo sapiens lactase phlorizinhydrolas... 168 2e-41
X07994-1|CAA30801.1| 1927|Homo sapiens protein ( Human mRNA for ... 168 2e-41
AC011893-3|AAX88924.1| 1927|Homo sapiens unknown protein. 168 2e-41
AY191611-1|AAP12677.1| 1003|Homo sapiens lactase-phlorizin hydro... 142 1e-33
AY358729-1|AAQ89091.1| 567|Homo sapiens KPVW3022 protein. 141 2e-33
BC113653-1|AAI13654.1| 1044|Homo sapiens klotho beta protein. 90 7e-18
BC104871-1|AAI04872.1| 1044|Homo sapiens klotho beta protein. 90 7e-18
AB079373-1|BAC56857.1| 1044|Homo sapiens klotho beta like protei... 90 7e-18
BC109377-1|AAI09378.1| 162|Homo sapiens GBA3 protein protein. 77 9e-14
BC070188-1|AAH70188.1| 162|Homo sapiens GBA3 protein protein. 77 9e-14
BC029362-1|AAH29362.1| 162|Homo sapiens GBA3 protein protein. 77 9e-14
Z84483-1|CAC94773.1| 739|Homo sapiens 46H23.1 (Klotho) protein. 75 4e-13
AL161898-1|CAH71888.1| 1012|Homo sapiens klotho protein. 75 4e-13
AB009667-2|BAA24941.1| 549|Homo sapiens Klotho protein (KL) pro... 75 4e-13
AB009667-1|BAA24940.1| 1012|Homo sapiens Klotho protein (KL) pro... 75 4e-13
AB005142-1|BAA23382.1| 1012|Homo sapiens klotho protein. 75 4e-13
BC033021-1|AAH33021.1| 305|Homo sapiens KLB protein protein. 63 1e-09
CR456790-1|CAG33071.1| 537|Homo sapiens CPNE1 protein. 31 4.7
U83246-1|AAC15920.1| 537|Homo sapiens copine I protein. 31 6.1
BC001142-1|AAH01142.1| 537|Homo sapiens copine I protein. 31 6.1
AL109827-11|CAI20122.1| 386|Homo sapiens copine I protein. 31 6.1
AL109827-10|CAO72111.1| 481|Homo sapiens copine I protein. 31 6.1
AL109827-9|CAB87610.2| 537|Homo sapiens copine I protein. 31 6.1
AB209827-1|BAD93064.1| 517|Homo sapiens copine I variant protein. 31 6.1
AB209169-1|BAD92406.1| 208|Homo sapiens growth differentiation ... 30 8.1
>BC101829-1|AAI01830.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 177 bits (430), Expect = 5e-44
Identities = 81/224 (36%), Positives = 135/224 (60%), Gaps = 1/224 (0%)
Frame = -1
Query: 755 TSRVGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGV 576
T + ++ PIF +G +P+ + +++A S + GYP +RLP+ +EEE+ +I+GTADFF V
Sbjct: 248 TFHLDLFAKPIFI-DGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTADFFAV 306
Query: 575 NHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKN 396
+YT L+ ++ + + + D + + P W W+ ++P + +L ++K+
Sbjct: 307 QYYTTRLIKYQEN--KKGELGILQDAEIEFFPDPSWKN--VDWIYVVPWGVCKLLKYIKD 362
Query: 395 KYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRLKGYMAWSLMDN 219
YN+P+ Y+TENG+ S L+D R Y+R + + ++ V L+ Y AWSL+DN
Sbjct: 363 TYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDN 422
Query: 218 YEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 87
+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 423 FEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 466
>AF323990-1|AAL37305.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 177 bits (430), Expect = 5e-44
Identities = 81/224 (36%), Positives = 135/224 (60%), Gaps = 1/224 (0%)
Frame = -1
Query: 755 TSRVGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGV 576
T + ++ PIF +G +P+ + +++A S + GYP +RLP+ +EEE+ +I+GTADFF V
Sbjct: 248 TFHLDLFAKPIFI-DGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTADFFAV 306
Query: 575 NHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKN 396
+YT L+ ++ + + + D + + P W W+ ++P + +L ++K+
Sbjct: 307 QYYTTRLIKYQEN--KKGELGILQDAEIEFFPDPSWKN--VDWIYVVPWGVCKLLKYIKD 362
Query: 395 KYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRLKGYMAWSLMDN 219
YN+P+ Y+TENG+ S L+D R Y+R + + ++ V L+ Y AWSL+DN
Sbjct: 363 TYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDN 422
Query: 218 YEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 87
+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 423 FEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 466
>AF317840-1|AAG39217.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 177 bits (430), Expect = 5e-44
Identities = 81/224 (36%), Positives = 135/224 (60%), Gaps = 1/224 (0%)
Frame = -1
Query: 755 TSRVGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGV 576
T + ++ PIF +G +P+ + +++A S + GYP +RLP+ +EEE+ +I+GTADFF V
Sbjct: 248 TFHLDLFAKPIFI-DGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTADFFAV 306
Query: 575 NHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKN 396
+YT L+ ++ + + + D + + P W W+ ++P + +L ++K+
Sbjct: 307 QYYTTRLIKYQEN--KKGELGILQDAEIEFFPDPSWKN--VDWIYVVPWGVCKLLKYIKD 362
Query: 395 KYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRLKGYMAWSLMDN 219
YN+P+ Y+TENG+ S L+D R Y+R + + ++ V L+ Y AWSL+DN
Sbjct: 363 TYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDN 422
Query: 218 YEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 87
+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 423 FEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 466
>AB017913-1|BAB18741.1| 469|Homo sapiens cytosolic
beta-glucosidase-like protein-1 protein.
Length = 469
Score = 177 bits (430), Expect = 5e-44
Identities = 81/224 (36%), Positives = 135/224 (60%), Gaps = 1/224 (0%)
Frame = -1
Query: 755 TSRVGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGV 576
T + ++ PIF +G +P+ + +++A S + GYP +RLP+ +EEE+ +I+GTADFF V
Sbjct: 248 TFHLDLFAKPIFI-DGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTADFFAV 306
Query: 575 NHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKN 396
+YT L+ ++ + + + D + + P W W+ ++P + +L ++K+
Sbjct: 307 QYYTTRLIKYQEN--KKGELGILQDAEIEFFPDPSWKN--VDWIYVVPWGVCKLLKYIKD 362
Query: 395 KYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRLKGYMAWSLMDN 219
YN+P+ Y+TENG+ S L+D R Y+R + + ++ V L+ Y AWSL+DN
Sbjct: 363 TYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDN 422
Query: 218 YEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 87
+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 423 FEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 466
>AJ278964-1|CAC08178.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 175 bits (427), Expect = 1e-43
Identities = 81/224 (36%), Positives = 134/224 (59%), Gaps = 1/224 (0%)
Frame = -1
Query: 755 TSRVGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGV 576
T + ++ PIF +G +P+ + +++A S + GYP +RLP+ +EEE+ +I+GTADFF V
Sbjct: 248 TFHLDLFAKPIFI-DGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTADFFAV 306
Query: 575 NHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKN 396
+YT L+ ++ + + D + + P W W+ ++P + +L ++K+
Sbjct: 307 QYYTTRLIKYQEN--KKGELGTLQDAEIEFFPDPSWKN--VDWIYVVPWGVCKLLKYIKD 362
Query: 395 KYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRLKGYMAWSLMDN 219
YN+P+ Y+TENG+ S L+D R Y+R + + ++ V L+ Y AWSL+DN
Sbjct: 363 TYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDN 422
Query: 218 YEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 87
+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 423 FEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 466
>AK222963-1|BAD96683.1| 469|Homo sapiens cytosolic beta-glucosidase
variant protein.
Length = 469
Score = 173 bits (421), Expect = 6e-43
Identities = 80/224 (35%), Positives = 134/224 (59%), Gaps = 1/224 (0%)
Frame = -1
Query: 755 TSRVGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGV 576
T + ++ PIF +G +P+ + +++A S + GYP +RLP+ +EEE+ +I+GTADFF V
Sbjct: 248 TFHLDLFAKPIFI-DGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTADFFAV 306
Query: 575 NHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKN 396
+ T L+ ++ + + + D + + P W W+ ++P + +L ++K+
Sbjct: 307 QYCTTRLIKYQEN--KRGELGILQDAEIEFFPDPSWKN--VDWIYVVPWGVCKLLKYIKD 362
Query: 395 KYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRLKGYMAWSLMDN 219
YN+P+ Y+TENG+ S L+D R Y+R + + ++ V L+ Y AWSL+DN
Sbjct: 363 TYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAWSLLDN 422
Query: 218 YEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 87
+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 423 FEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 466
>M61850-1|AAA59504.1| 1927|Homo sapiens lactase phlorizinhydrolase
protein.
Length = 1927
Score = 168 bits (409), Expect = 2e-41
Identities = 84/214 (39%), Positives = 119/214 (55%)
Frame = -1
Query: 743 GIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYT 564
G + HPIF + G + + + R+ ++S G ++RLP+ +E E+ I GT DFFG NHYT
Sbjct: 1626 GWFAHPIF-KNGDYSEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGFNHYT 1684
Query: 563 GYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYND 384
L + S S +D V + W S + WL + P +L LK +YND
Sbjct: 1685 TVLAYNLNYATAIS--SFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEYND 1742
Query: 383 PIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAGVRLKGYMAWSLMDNYEWMA 204
P YVTENG + E L D RI Y R + L ++ V L+GY WS MDN+EW
Sbjct: 1743 PPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEWAT 1802
Query: 203 GYTERFGLYEVDFSDPARPRTPRKSAFVYKEILR 102
G++ERFGL+ V++SDP+ PR P+ SA Y ++R
Sbjct: 1803 GFSERFGLHFVNYSDPSLPRIPKASAKFYASVVR 1836
Score = 142 bits (344), Expect = 1e-33
Identities = 83/217 (38%), Positives = 118/217 (54%), Gaps = 3/217 (1%)
Frame = -1
Query: 746 VGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHY 567
+G + HPIF + G +P + +V +S +RLP +EEE+ IR TAD F +N Y
Sbjct: 1151 LGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRATADVFCLNTY 1209
Query: 566 TGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYN 387
+V P + S D + P W +A + P +L +K +Y
Sbjct: 1210 YSRIVQ--HKTPRLNPPSYEDDQEMAEEEDPSWPSTAMN--RAAPWGTRRLLNWIKEEYG 1265
Query: 386 DPIFYVTENGWA-TSPEVGLEDDDRITYYRAALENILDS--LDAGVRLKGYMAWSLMDNY 216
D Y+TENG T+P ED DRI Y++ + L + LD G+ L+GY+AWSLMDN+
Sbjct: 1266 DIPIYITENGVGLTNPNT--EDTDRIFYHKTYINEALKAYRLD-GIDLRGYVAWSLMDNF 1322
Query: 215 EWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 105
EW+ GYT +FGLY VDF++ RPRT R SA Y E++
Sbjct: 1323 EWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVI 1359
Score = 134 bits (323), Expect = 4e-31
Identities = 74/222 (33%), Positives = 130/222 (58%), Gaps = 8/222 (3%)
Frame = -1
Query: 746 VGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHY 567
+G + HP+F +G +P L ++ + + + +P +LP+ +E E+ L++G+ADF G++HY
Sbjct: 628 LGWFAHPVFV-DGDYPATLRTQIQQMNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHY 686
Query: 566 TGYLVSATKH---IPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKN 396
T L+S IP Y T+ FS +V + W Q+++SW+ ++P I +L +
Sbjct: 687 TSRLISNAPQNTCIPSYDTIGGFSQ-HVNHV----WPQTSSSWIRVVPWGIRRLLQFVSL 741
Query: 395 KYND---PIFYVTENGWATSPEVGLEDDD-RITYYRAALENILDSL-DAGVRLKGYMAWS 231
+Y PI Y+ NG L DD R+ Y+ + +L ++ + V ++ Y+A S
Sbjct: 742 EYTRGKVPI-YLAGNGMPIGESENLFDDSLRVDYFNQYINEVLKAIKEDSVDVRSYIARS 800
Query: 230 LMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 105
L+D +E +GY++RFGL+ V+FSD ++ RTPRKSA+ + I+
Sbjct: 801 LIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTSII 842
>X07994-1|CAA30801.1| 1927|Homo sapiens protein ( Human mRNA for
lactase-phlorizin hydrolase LPH (EC 3.2.1.23-62). ).
Length = 1927
Score = 168 bits (408), Expect = 2e-41
Identities = 84/214 (39%), Positives = 119/214 (55%)
Frame = -1
Query: 743 GIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYT 564
G + HPIF + G + + + R+ ++S G ++RLP+ +E E+ I GT DFFG NHYT
Sbjct: 1626 GWFAHPIF-KNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGFNHYT 1684
Query: 563 GYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYND 384
L + S S +D V + W S + WL + P +L LK +YND
Sbjct: 1685 TVLAYNLNYATAIS--SFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEYND 1742
Query: 383 PIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAGVRLKGYMAWSLMDNYEWMA 204
P YVTENG + E L D RI Y R + L ++ V L+GY WS MDN+EW
Sbjct: 1743 PPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEWAT 1802
Query: 203 GYTERFGLYEVDFSDPARPRTPRKSAFVYKEILR 102
G++ERFGL+ V++SDP+ PR P+ SA Y ++R
Sbjct: 1803 GFSERFGLHFVNYSDPSLPRIPKASAKFYASVVR 1836
Score = 142 bits (344), Expect = 1e-33
Identities = 83/217 (38%), Positives = 118/217 (54%), Gaps = 3/217 (1%)
Frame = -1
Query: 746 VGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHY 567
+G + HPIF + G +P + +V +S +RLP +EEE+ IR TAD F +N Y
Sbjct: 1151 LGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRATADVFCLNTY 1209
Query: 566 TGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYN 387
+V P + S D + P W +A + P +L +K +Y
Sbjct: 1210 YSRIVQ--HKTPRLNPPSYEDDQEMAEEEDPSWPSTAMN--RAAPWGTRRLLNWIKEEYG 1265
Query: 386 DPIFYVTENGWA-TSPEVGLEDDDRITYYRAALENILDS--LDAGVRLKGYMAWSLMDNY 216
D Y+TENG T+P ED DRI Y++ + L + LD G+ L+GY+AWSLMDN+
Sbjct: 1266 DIPIYITENGVGLTNPNT--EDTDRIFYHKTYINEALKAYRLD-GIDLRGYVAWSLMDNF 1322
Query: 215 EWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 105
EW+ GYT +FGLY VDF++ RPRT R SA Y E++
Sbjct: 1323 EWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVI 1359
Score = 134 bits (323), Expect = 4e-31
Identities = 74/222 (33%), Positives = 130/222 (58%), Gaps = 8/222 (3%)
Frame = -1
Query: 746 VGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHY 567
+G + HP+F +G +P L ++ + + + +P +LP+ +E E+ L++G+ADF G++HY
Sbjct: 628 LGWFAHPVFV-DGDYPATLRTQIQQMNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHY 686
Query: 566 TGYLVSATKH---IPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKN 396
T L+S IP Y T+ FS +V + W Q+++SW+ ++P I +L +
Sbjct: 687 TSRLISNAPQNTCIPSYDTIGGFSQ-HVNHV----WPQTSSSWIRVVPWGIRRLLQFVSL 741
Query: 395 KYND---PIFYVTENGWATSPEVGLEDDD-RITYYRAALENILDSL-DAGVRLKGYMAWS 231
+Y PI Y+ NG L DD R+ Y+ + +L ++ + V ++ Y+A S
Sbjct: 742 EYTRGKVPI-YLAGNGMPIGESENLFDDSLRVDYFNQYINEVLKAIKEDSVDVRSYIARS 800
Query: 230 LMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 105
L+D +E +GY++RFGL+ V+FSD ++ RTPRKSA+ + I+
Sbjct: 801 LIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTSII 842
>AC011893-3|AAX88924.1| 1927|Homo sapiens unknown protein.
Length = 1927
Score = 168 bits (408), Expect = 2e-41
Identities = 84/214 (39%), Positives = 119/214 (55%)
Frame = -1
Query: 743 GIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYT 564
G + HPIF + G + + + R+ ++S G ++RLP+ +E E+ I GT DFFG NHYT
Sbjct: 1626 GWFAHPIF-KNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGFNHYT 1684
Query: 563 GYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYND 384
L + S S +D V + W S + WL + P +L LK +YND
Sbjct: 1685 TVLAYNLNYATAIS--SFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEYND 1742
Query: 383 PIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAGVRLKGYMAWSLMDNYEWMA 204
P YVTENG + E L D RI Y R + L ++ V L+GY WS MDN+EW
Sbjct: 1743 PPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEWAT 1802
Query: 203 GYTERFGLYEVDFSDPARPRTPRKSAFVYKEILR 102
G++ERFGL+ V++SDP+ PR P+ SA Y ++R
Sbjct: 1803 GFSERFGLHFVNYSDPSLPRIPKASAKFYASVVR 1836
Score = 142 bits (344), Expect = 1e-33
Identities = 83/217 (38%), Positives = 118/217 (54%), Gaps = 3/217 (1%)
Frame = -1
Query: 746 VGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHY 567
+G + HPIF + G +P + +V +S +RLP +EEE+ IR TAD F +N Y
Sbjct: 1151 LGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRATADVFCLNTY 1209
Query: 566 TGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYN 387
+V P + S D + P W +A + P +L +K +Y
Sbjct: 1210 YSRIVQ--HKTPRLNPPSYEDDQEMAEEEDPSWPSTAMN--RAAPWGTRRLLNWIKEEYG 1265
Query: 386 DPIFYVTENGWA-TSPEVGLEDDDRITYYRAALENILDS--LDAGVRLKGYMAWSLMDNY 216
D Y+TENG T+P ED DRI Y++ + L + LD G+ L+GY+AWSLMDN+
Sbjct: 1266 DIPIYITENGVGLTNPNT--EDTDRIFYHKTYINEALKAYRLD-GIDLRGYVAWSLMDNF 1322
Query: 215 EWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 105
EW+ GYT +FGLY VDF++ RPRT R SA Y E++
Sbjct: 1323 EWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVI 1359
Score = 134 bits (323), Expect = 4e-31
Identities = 74/222 (33%), Positives = 130/222 (58%), Gaps = 8/222 (3%)
Frame = -1
Query: 746 VGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHY 567
+G + HP+F +G +P L ++ + + + +P +LP+ +E E+ L++G+ADF G++HY
Sbjct: 628 LGWFAHPVFV-DGDYPATLRTQIQQMNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHY 686
Query: 566 TGYLVSATKH---IPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKN 396
T L+S IP Y T+ FS +V + W Q+++SW+ ++P I +L +
Sbjct: 687 TSRLISNAPQNTCIPSYDTIGGFSQ-HVNHV----WPQTSSSWIRVVPWGIRRLLQFVSL 741
Query: 395 KYND---PIFYVTENGWATSPEVGLEDDD-RITYYRAALENILDSL-DAGVRLKGYMAWS 231
+Y PI Y+ NG L DD R+ Y+ + +L ++ + V ++ Y+A S
Sbjct: 742 EYTRGKVPI-YLAGNGMPIGESENLFDDSLRVDYFNQYINEVLKAIKEDSVDVRSYIARS 800
Query: 230 LMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 105
L+D +E +GY++RFGL+ V+FSD ++ RTPRKSA+ + I+
Sbjct: 801 LIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTSII 842
>AY191611-1|AAP12677.1| 1003|Homo sapiens lactase-phlorizin
hydrolase-1 protein.
Length = 1003
Score = 142 bits (344), Expect = 1e-33
Identities = 83/217 (38%), Positives = 118/217 (54%), Gaps = 3/217 (1%)
Frame = -1
Query: 746 VGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHY 567
+G + HPIF + G +P + +V +S +RLP +EEE+ IR TAD F +N Y
Sbjct: 583 LGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRATADVFCLNTY 641
Query: 566 TGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYN 387
+V P + S D + P W +A + P +L +K +Y
Sbjct: 642 YSRIVQ--HKTPRLNPPSYEDDQEMAEEEDPSWPSTAMN--RAAPWGTRRLLNWIKEEYG 697
Query: 386 DPIFYVTENGWA-TSPEVGLEDDDRITYYRAALENILDS--LDAGVRLKGYMAWSLMDNY 216
D Y+TENG T+P ED DRI Y++ + L + LD G+ L+GY+AWSLMDN+
Sbjct: 698 DIPIYITENGVGLTNPNT--EDTDRIFYHKTYINEALKAYRLD-GIDLRGYVAWSLMDNF 754
Query: 215 EWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 105
EW+ GYT +FGLY VDF++ RPRT R SA Y E++
Sbjct: 755 EWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVI 791
Score = 134 bits (323), Expect = 4e-31
Identities = 74/222 (33%), Positives = 130/222 (58%), Gaps = 8/222 (3%)
Frame = -1
Query: 746 VGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHY 567
+G + HP+F +G +P L ++ + + + +P +LP+ +E E+ L++G+ADF G++HY
Sbjct: 60 LGWFAHPVFV-DGDYPATLRTQIQQMNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHY 118
Query: 566 TGYLVSATKH---IPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKN 396
T L+S IP Y T+ FS +V + W Q+++SW+ ++P I +L +
Sbjct: 119 TSRLISNAPQNTCIPSYDTIGGFSQ-HVNHV----WPQTSSSWIRVVPWGIRRLLQFVSL 173
Query: 395 KYND---PIFYVTENGWATSPEVGLEDDD-RITYYRAALENILDSL-DAGVRLKGYMAWS 231
+Y PI Y+ NG L DD R+ Y+ + +L ++ + V ++ Y+A S
Sbjct: 174 EYTRGKVPI-YLAGNGMPIGESENLFDDSLRVDYFNQYINEVLKAIKEDSVDVRSYIARS 232
Query: 230 LMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 105
L+D +E +GY++RFGL+ V+FSD ++ RTPRKSA+ + I+
Sbjct: 233 LIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTSII 274
>AY358729-1|AAQ89091.1| 567|Homo sapiens KPVW3022 protein.
Length = 567
Score = 141 bits (342), Expect = 2e-33
Identities = 71/215 (33%), Positives = 119/215 (55%), Gaps = 1/215 (0%)
Frame = -1
Query: 746 VGIYVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHY 567
+G + +PI++ G +P+ + + KSAE G +RLP S +E+ I+GT+DF G+ H+
Sbjct: 287 LGWFANPIYA--GDYPQVMKDYIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHF 344
Query: 566 TGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYN 387
T ++ ++ P S +D ++ P W + WL +P +L + +Y
Sbjct: 345 TTRYITE-RNYPSRQGPSYQNDRDLIELVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYG 403
Query: 386 DPIFYVTENGWATSPE-VGLEDDDRITYYRAALENILDSLDAGVRLKGYMAWSLMDNYEW 210
DP YV ENG + L D+ RI Y + + +L ++ G +KGY +WSL+D +EW
Sbjct: 404 DPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKAIKDGANIKGYTSWSLLDKFEW 463
Query: 209 MAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 105
GY++R+G Y V+F+D +PR P+ S YK+I+
Sbjct: 464 EKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKII 498
>BC113653-1|AAI13654.1| 1044|Homo sapiens klotho beta protein.
Length = 1044
Score = 90.2 bits (214), Expect = 7e-18
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 1/110 (0%)
Frame = -1
Query: 428 SIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRL 252
++ + L +K +YN+P + ENGW T V ED I + L +L ++ +R+
Sbjct: 395 NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRV 454
Query: 251 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILR 102
GY AWSL+D +EW YT R GL+ VDF+ + R P+ SA YK+I+R
Sbjct: 455 FGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIR 504
Score = 62.9 bits (146), Expect = 1e-09
Identities = 54/193 (27%), Positives = 88/193 (45%), Gaps = 2/193 (1%)
Frame = -1
Query: 737 YVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGY 558
+ P+F + G +P + +A K G + LP+L+E ER L++GT DF +NH+T
Sbjct: 772 FAEPLF-KTGDYPAAMREYIASKH-RRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTR 829
Query: 557 LVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPI 378
V + E S + + S+ + L ++P + +L ++ Y D
Sbjct: 830 FV-----MHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMD 884
Query: 377 FYVTENGWATSPEVGLEDDDRITYYRAA-LENILDS-LDAGVRLKGYMAWSLMDNYEWMA 204
Y+T +G + LEDD YY L+ +L + L VR+KGY A+ L +
Sbjct: 885 IYITASG---IDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKS--- 938
Query: 203 GYTERFGLYEVDF 165
RFG + DF
Sbjct: 939 --KPRFGFFTSDF 949
>BC104871-1|AAI04872.1| 1044|Homo sapiens klotho beta protein.
Length = 1044
Score = 90.2 bits (214), Expect = 7e-18
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 1/110 (0%)
Frame = -1
Query: 428 SIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRL 252
++ + L +K +YN+P + ENGW T V ED I + L +L ++ +R+
Sbjct: 395 NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRV 454
Query: 251 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILR 102
GY AWSL+D +EW YT R GL+ VDF+ + R P+ SA YK+I+R
Sbjct: 455 FGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIR 504
Score = 62.9 bits (146), Expect = 1e-09
Identities = 54/193 (27%), Positives = 88/193 (45%), Gaps = 2/193 (1%)
Frame = -1
Query: 737 YVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGY 558
+ P+F + G +P + +A K G + LP+L+E ER L++GT DF +NH+T
Sbjct: 772 FAEPLF-KTGDYPAAMREYIASKH-RRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTR 829
Query: 557 LVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPI 378
V + E S + + S+ + L ++P + +L ++ Y D
Sbjct: 830 FV-----MHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMD 884
Query: 377 FYVTENGWATSPEVGLEDDDRITYYRAA-LENILDS-LDAGVRLKGYMAWSLMDNYEWMA 204
Y+T +G + LEDD YY L+ +L + L VR+KGY A+ L +
Sbjct: 885 IYITASG---IDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKS--- 938
Query: 203 GYTERFGLYEVDF 165
RFG + DF
Sbjct: 939 --KPRFGFFTSDF 949
>AB079373-1|BAC56857.1| 1044|Homo sapiens klotho beta like protein
protein.
Length = 1044
Score = 90.2 bits (214), Expect = 7e-18
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 1/110 (0%)
Frame = -1
Query: 428 SIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENILDSLDAG-VRL 252
++ + L +K +YN+P + ENGW T V ED I + L +L ++ +R+
Sbjct: 395 NLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRV 454
Query: 251 KGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILR 102
GY AWSL+D +EW YT R GL+ VDF+ + R P+ SA YK+I+R
Sbjct: 455 FGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIR 504
Score = 62.9 bits (146), Expect = 1e-09
Identities = 54/193 (27%), Positives = 88/193 (45%), Gaps = 2/193 (1%)
Frame = -1
Query: 737 YVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGY 558
+ P+F + G +P + +A K G + LP+L+E ER L++GT DF +NH+T
Sbjct: 772 FAEPLF-KTGDYPAAMREYIASKH-RRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTR 829
Query: 557 LVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPI 378
V + E S + + S+ + L ++P + +L ++ Y D
Sbjct: 830 FV-----MHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMD 884
Query: 377 FYVTENGWATSPEVGLEDDDRITYYRAA-LENILDS-LDAGVRLKGYMAWSLMDNYEWMA 204
Y+T +G + LEDD YY L+ +L + L VR+KGY A+ L +
Sbjct: 885 IYITASG---IDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKS--- 938
Query: 203 GYTERFGLYEVDF 165
RFG + DF
Sbjct: 939 --KPRFGFFTSDF 949
>BC109377-1|AAI09378.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 76.6 bits (180), Expect = 9e-14
Identities = 32/58 (55%), Positives = 42/58 (72%)
Frame = -1
Query: 260 VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 87
V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 102 VNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 159
>BC070188-1|AAH70188.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 76.6 bits (180), Expect = 9e-14
Identities = 32/58 (55%), Positives = 42/58 (72%)
Frame = -1
Query: 260 VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 87
V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 102 VNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 159
>BC029362-1|AAH29362.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 76.6 bits (180), Expect = 9e-14
Identities = 32/58 (55%), Positives = 42/58 (72%)
Frame = -1
Query: 260 VRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEILRSRVID 87
V L+ Y AWSL+DN+EW GY+ RFGL+ VDF DPARPR P SA Y +I+R+ ++
Sbjct: 102 VNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLE 159
>Z84483-1|CAC94773.1| 739|Homo sapiens 46H23.1 (Klotho) protein.
Length = 739
Score = 74.5 bits (175), Expect = 4e-13
Identities = 54/179 (30%), Positives = 80/179 (44%), Gaps = 1/179 (0%)
Frame = -1
Query: 638 LPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQS 459
LP +E E+ I+GTADFF A P S L + P L+
Sbjct: 76 LPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFRQLESPN-LRQ 123
Query: 458 AASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENIL 279
SW+ L ++N P ++ ENGW S +D + Y + + L
Sbjct: 124 LLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETL 169
Query: 278 DSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 105
++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+ SA Y++++
Sbjct: 170 KAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLI 228
Score = 66.9 bits (156), Expect = 8e-11
Identities = 59/183 (32%), Positives = 85/183 (46%), Gaps = 3/183 (1%)
Frame = -1
Query: 638 LPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQS 459
LP +E+E+ LI+GT DF ++HYT LV + K P + + V WL S
Sbjct: 513 LPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDP----IKYNDYLEVQEMTDITWLNS 568
Query: 458 AASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDD-RITYYRAALENI 282
S + ++P + VL LK KY D Y+ NG + EDD R+ Y + +
Sbjct: 569 -PSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNG--IDDGLHAEDDQLRVYYMQNYINEA 625
Query: 281 LDS--LDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEI 108
L + LD G+ L GY A+S D RFGLY +D P+ K Y++I
Sbjct: 626 LKAHILD-GINLCGYFAYSFNDR------TAPRFGLYRY-AADQFEPKASMKH---YRKI 674
Query: 107 LRS 99
+ S
Sbjct: 675 IDS 677
>AL161898-1|CAH71888.1| 1012|Homo sapiens klotho protein.
Length = 1012
Score = 74.5 bits (175), Expect = 4e-13
Identities = 54/179 (30%), Positives = 80/179 (44%), Gaps = 1/179 (0%)
Frame = -1
Query: 638 LPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQS 459
LP +E E+ I+GTADFF A P S L + P L+
Sbjct: 349 LPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFRQLESPN-LRQ 396
Query: 458 AASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENIL 279
SW+ L ++N P ++ ENGW S +D + Y + + L
Sbjct: 397 LLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETL 442
Query: 278 DSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 105
++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+ SA Y++++
Sbjct: 443 KAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLI 501
Score = 66.9 bits (156), Expect = 8e-11
Identities = 59/183 (32%), Positives = 85/183 (46%), Gaps = 3/183 (1%)
Frame = -1
Query: 638 LPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQS 459
LP +E+E+ LI+GT DF ++HYT LV + K P + + V WL S
Sbjct: 786 LPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDP----IKYNDYLEVQEMTDITWLNS 841
Query: 458 AASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDD-RITYYRAALENI 282
S + ++P + VL LK KY D Y+ NG + EDD R+ Y + +
Sbjct: 842 -PSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNG--IDDGLHAEDDQLRVYYMQNYINEA 898
Query: 281 LDS--LDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEI 108
L + LD G+ L GY A+S D RFGLY +D P+ K Y++I
Sbjct: 899 LKAHILD-GINLCGYFAYSFNDR------TAPRFGLYRY-AADQFEPKASMKH---YRKI 947
Query: 107 LRS 99
+ S
Sbjct: 948 IDS 950
>AB009667-2|BAA24941.1| 549|Homo sapiens Klotho protein (KL)
protein.
Length = 549
Score = 74.5 bits (175), Expect = 4e-13
Identities = 54/179 (30%), Positives = 80/179 (44%), Gaps = 1/179 (0%)
Frame = -1
Query: 638 LPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQS 459
LP +E E+ I+GTADFF A P S L + P L+
Sbjct: 349 LPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFRQLESPN-LRQ 396
Query: 458 AASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENIL 279
SW+ L ++N P ++ ENGW S +D + Y + + L
Sbjct: 397 LLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETL 442
Query: 278 DSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 105
++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+ SA Y++++
Sbjct: 443 KAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLI 501
>AB009667-1|BAA24940.1| 1012|Homo sapiens Klotho protein (KL)
protein.
Length = 1012
Score = 74.5 bits (175), Expect = 4e-13
Identities = 54/179 (30%), Positives = 80/179 (44%), Gaps = 1/179 (0%)
Frame = -1
Query: 638 LPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQS 459
LP +E E+ I+GTADFF A P S L + P L+
Sbjct: 349 LPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFRQLESPN-LRQ 396
Query: 458 AASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENIL 279
SW+ L ++N P ++ ENGW S +D + Y + + L
Sbjct: 397 LLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETL 442
Query: 278 DSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 105
++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+ SA Y++++
Sbjct: 443 KAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLI 501
Score = 66.9 bits (156), Expect = 8e-11
Identities = 59/183 (32%), Positives = 85/183 (46%), Gaps = 3/183 (1%)
Frame = -1
Query: 638 LPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQS 459
LP +E+E+ LI+GT DF ++HYT LV + K P + + V WL S
Sbjct: 786 LPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDP----IKYNDYLEVQEMTDITWLNS 841
Query: 458 AASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDD-RITYYRAALENI 282
S + ++P + VL LK KY D Y+ NG + EDD R+ Y + +
Sbjct: 842 -PSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNG--IDDGLHAEDDQLRVYYMQNYINEA 898
Query: 281 LDS--LDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEI 108
L + LD G+ L GY A+S D RFGLY +D P+ K Y++I
Sbjct: 899 LKAHILD-GINLCGYFAYSFNDR------TAPRFGLYRY-AADQFEPKASMKH---YRKI 947
Query: 107 LRS 99
+ S
Sbjct: 948 IDS 950
>AB005142-1|BAA23382.1| 1012|Homo sapiens klotho protein.
Length = 1012
Score = 74.5 bits (175), Expect = 4e-13
Identities = 54/179 (30%), Positives = 80/179 (44%), Gaps = 1/179 (0%)
Frame = -1
Query: 638 LPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQS 459
LP +E E+ I+GTADFF A P S L + P L+
Sbjct: 349 LPDFTESEKKFIKGTADFF-----------ALCFGPTLSFQLLDPHMKFRQLESPN-LRQ 396
Query: 458 AASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDDRITYYRAALENIL 279
SW+ L ++N P ++ ENGW S +D + Y + + L
Sbjct: 397 LLSWIDL--------------EFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETL 442
Query: 278 DSLDA-GVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEIL 105
++ GV + GY AWSLMD +EW GY+ R GL+ VDF + P+ SA Y++++
Sbjct: 443 KAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLI 501
Score = 66.9 bits (156), Expect = 8e-11
Identities = 59/183 (32%), Positives = 85/183 (46%), Gaps = 3/183 (1%)
Frame = -1
Query: 638 LPQLSEEERVLIRGTADFFGVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQS 459
LP +E+E+ LI+GT DF ++HYT LV + K P + + V WL S
Sbjct: 786 LPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDP----IKYNDYLEVQEMTDITWLNS 841
Query: 458 AASWLTLMPNSIYDVLTHLKNKYNDPIFYVTENGWATSPEVGLEDDD-RITYYRAALENI 282
S + ++P + VL LK KY D Y+ NG + EDD R+ Y + +
Sbjct: 842 -PSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNG--IDDGLHAEDDQLRVYYMQNYINEA 898
Query: 281 LDS--LDAGVRLKGYMAWSLMDNYEWMAGYTERFGLYEVDFSDPARPRTPRKSAFVYKEI 108
L + LD G+ L GY A+S D RFGLY +D P+ K Y++I
Sbjct: 899 LKAHILD-GINLCGYFAYSFNDR------TAPRFGLYRY-AADQFEPKASMKH---YRKI 947
Query: 107 LRS 99
+ S
Sbjct: 948 IDS 950
>BC033021-1|AAH33021.1| 305|Homo sapiens KLB protein protein.
Length = 305
Score = 62.9 bits (146), Expect = 1e-09
Identities = 54/193 (27%), Positives = 88/193 (45%), Gaps = 2/193 (1%)
Frame = -1
Query: 737 YVHPIFSQEGGFPKELVARVAEKSAEHGYPRTRLPQLSEEERVLIRGTADFFGVNHYTGY 558
+ P+F + G +P + +A K G + LP+L+E ER L++GT DF +NH+T
Sbjct: 33 FAEPLF-KTGDYPAAMREYIASKH-RRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTR 90
Query: 557 LVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDVLTHLKNKYNDPI 378
V + E S + + S+ + L ++P + +L ++ Y D
Sbjct: 91 FV-----MHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMD 145
Query: 377 FYVTENGWATSPEVGLEDDDRITYYRAA-LENILDS-LDAGVRLKGYMAWSLMDNYEWMA 204
Y+T +G + LEDD YY L+ +L + L VR+KGY A+ L +
Sbjct: 146 IYITASG---IDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKS--- 199
Query: 203 GYTERFGLYEVDF 165
RFG + DF
Sbjct: 200 --KPRFGFFTSDF 210
>CR456790-1|CAG33071.1| 537|Homo sapiens CPNE1 protein.
Length = 537
Score = 31.1 bits (67), Expect = 4.7
Identities = 18/56 (32%), Positives = 24/56 (42%)
Frame = -1
Query: 581 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIYDV 414
GVN Y L S + +Y + LF G PP+W S L P++ Y V
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPYCV 367
>U83246-1|AAC15920.1| 537|Homo sapiens copine I protein.
Length = 537
Score = 30.7 bits (66), Expect = 6.1
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -1
Query: 581 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 420
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 365
>BC001142-1|AAH01142.1| 537|Homo sapiens copine I protein.
Length = 537
Score = 30.7 bits (66), Expect = 6.1
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -1
Query: 581 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 420
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 365
>AL109827-11|CAI20122.1| 386|Homo sapiens copine I protein.
Length = 386
Score = 30.7 bits (66), Expect = 6.1
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -1
Query: 581 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 420
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 288 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 341
>AL109827-10|CAO72111.1| 481|Homo sapiens copine I protein.
Length = 481
Score = 30.7 bits (66), Expect = 6.1
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -1
Query: 581 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 420
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 365
>AL109827-9|CAB87610.2| 537|Homo sapiens copine I protein.
Length = 537
Score = 30.7 bits (66), Expect = 6.1
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -1
Query: 581 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 420
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 312 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 365
>AB209827-1|BAD93064.1| 517|Homo sapiens copine I variant protein.
Length = 517
Score = 30.7 bits (66), Expect = 6.1
Identities = 17/54 (31%), Positives = 23/54 (42%)
Frame = -1
Query: 581 GVNHYTGYLVSATKHIPEYSTVSLFSDINVGNYRPPEWLQSAASWLTLMPNSIY 420
GVN Y L S + +Y + LF G PP+W S L P++ Y
Sbjct: 292 GVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPY 345
>AB209169-1|BAD92406.1| 208|Homo sapiens growth differentiation
factor 1 variant protein.
Length = 208
Score = 30.3 bits (65), Expect = 8.1
Identities = 14/25 (56%), Positives = 16/25 (64%), Gaps = 1/25 (4%)
Frame = -3
Query: 153 PPSHPAQV-RVRLQGDLEEQGHRPR 82
PP HPA + R R G L +GHRPR
Sbjct: 71 PPPHPASISRPRPPGPLPLRGHRPR 95
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 119,570,746
Number of Sequences: 237096
Number of extensions: 2670099
Number of successful extensions: 10204
Number of sequences better than 10.0: 31
Number of HSP's better than 10.0 without gapping: 9952
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 10155
length of database: 76,859,062
effective HSP length: 89
effective length of database: 55,757,518
effective search space used: 9478778060
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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