Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fmgV11f13f
(615 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9VHB8 Cluster: CG8199-PA; n=2; Eukaryota|Rep: CG8199-P... 211 1e-53
UniRef50_Q295J7 Cluster: GA20891-PA; n=7; Coelomata|Rep: GA20891... 209 5e-53
UniRef50_P12694 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 204 1e-51
UniRef50_Q4A1S8 Cluster: Putative uncharacterized protein; n=4; ... 202 5e-51
UniRef50_A7RZV6 Cluster: Predicted protein; n=6; Eumetazoa|Rep: ... 189 5e-47
UniRef50_Q9LPL5 Cluster: Branched-chain alpha keto-acid dehydrog... 184 2e-45
UniRef50_A0DAM1 Cluster: Chromosome undetermined scaffold_43, wh... 159 4e-38
UniRef50_A6RV39 Cluster: Putative uncharacterized protein; n=1; ... 155 8e-37
UniRef50_Q4DB65 Cluster: 2-oxoisovalerate dehydrogenase alpha su... 149 7e-35
UniRef50_Q5KGR5 Cluster: Branched-chain alpha-keto acid dehydrog... 142 6e-33
UniRef50_Q4P2J0 Cluster: Putative uncharacterized protein; n=1; ... 141 1e-32
UniRef50_Q4Y3F8 Cluster: Branched-chain alpha keto-acid dehydrog... 138 1e-31
UniRef50_Q5QUK4 Cluster: Alpha keto acid dehydrogenase complex, ... 131 1e-29
UniRef50_Q4QC52 Cluster: 2-oxoisovalerate dehydrogenase alpha su... 128 8e-29
UniRef50_Q1KSF2 Cluster: Mitochondrial branched-chain alpha-keto... 118 1e-25
UniRef50_Q4N1L6 Cluster: Branched-chain alpha keto-acid dehydrog... 105 1e-21
UniRef50_A7HBV0 Cluster: 3-methyl-2-oxobutanoate dehydrogenase; ... 104 2e-21
UniRef50_Q9YBC0 Cluster: Pyruvate dehydrogenase E1 component, al... 95 1e-18
UniRef50_Q6YPX5 Cluster: Thiamine pyrophosphate-dependent dehydr... 94 3e-18
UniRef50_Q97CK0 Cluster: 2-oxoisovalerate dehydrogenase alpha su... 93 6e-18
UniRef50_P35485 Cluster: Pyruvate dehydrogenase E1 component sub... 81 2e-14
UniRef50_P09060 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 80 5e-14
UniRef50_P37940 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 80 5e-14
UniRef50_Q9RPS5 Cluster: TPP-dependent branched-chain alpha-keto... 77 3e-13
UniRef50_O48615 Cluster: Alpha-keto acid dehydrogenase-like prot... 77 3e-13
UniRef50_Q9HN77 Cluster: Pyruvate dehydrogenase alpha subunit; n... 76 8e-13
UniRef50_Q9RYC1 Cluster: 2-oxo acid dehydrogenase, E1 component,... 74 3e-12
UniRef50_Q020J5 Cluster: Dehydrogenase, E1 component; n=1; Solib... 73 7e-12
UniRef50_Q72GU1 Cluster: 2-oxoisovalerate dehydrogenase subunit ... 71 2e-11
UniRef50_A0M1U4 Cluster: 2-oxoisovalerate dehydrogenase E1 compo... 68 2e-10
UniRef50_Q5KUY4 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 68 2e-10
UniRef50_Q8CX87 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 66 5e-10
UniRef50_Q67ME6 Cluster: Branched-chain alpha-keto acid dehydrog... 66 8e-10
UniRef50_Q1IQR3 Cluster: Dehydrogenase, E1 component; n=1; Acido... 64 2e-09
UniRef50_A6CP23 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 64 2e-09
UniRef50_P47516 Cluster: Pyruvate dehydrogenase E1 component sub... 64 2e-09
UniRef50_Q4L1A7 Cluster: Pyruvate dehydrogenase E1 component alp... 64 3e-09
UniRef50_A5UU15 Cluster: Pyruvate dehydrogenase; n=3; Chloroflex... 62 1e-08
UniRef50_Q0W151 Cluster: Pyruvate dehydrogenase complex E1, tran... 62 1e-08
UniRef50_A1UJ85 Cluster: Pyruvate dehydrogenase; n=16; Mycobacte... 61 2e-08
UniRef50_Q6L1L8 Cluster: Pyruvate dehydrogenase E1 component alp... 60 3e-08
UniRef50_Q8ZUR8 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 59 7e-08
UniRef50_A6GB57 Cluster: Pyruvate dehydrogenase; n=1; Plesiocyst... 59 9e-08
UniRef50_P21873 Cluster: Pyruvate dehydrogenase E1 component sub... 58 1e-07
UniRef50_A7D3P2 Cluster: Pyruvate dehydrogenase; n=1; Halorubrum... 58 2e-07
UniRef50_Q9KG99 Cluster: Pyruvate dehydrogenase E1 (Lipoamide) a... 57 3e-07
UniRef50_A0K283 Cluster: Pyruvate dehydrogenase; n=4; Actinobact... 57 3e-07
UniRef50_A0LLM4 Cluster: Pyruvate dehydrogenase; n=1; Syntrophob... 56 7e-07
UniRef50_UPI00005103B4 Cluster: COG1071: Pyruvate/2-oxoglutarate... 55 1e-06
UniRef50_Q02C52 Cluster: Pyruvate dehydrogenase; n=1; Solibacter... 55 1e-06
UniRef50_A5UVY9 Cluster: Pyruvate dehydrogenase; n=2; Roseiflexu... 55 1e-06
UniRef50_Q835M4 Cluster: Pyruvate dehydrogenase complex E1 compo... 55 2e-06
UniRef50_Q7N5R1 Cluster: Similar to 3-methyl-2-oxobutanoate dehy... 55 2e-06
UniRef50_Q2J998 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp... 54 2e-06
UniRef50_A0JUQ5 Cluster: Pyruvate dehydrogenase; n=4; Actinobact... 54 2e-06
UniRef50_Q749T8 Cluster: Pyruvate dehydrogenase complex E1 compo... 54 4e-06
UniRef50_Q1LFS5 Cluster: Dehydrogenase, E1 component; n=22; Prot... 53 5e-06
UniRef50_Q8EVQ2 Cluster: Pyruvate dehydrogenase E1 component sub... 53 6e-06
UniRef50_Q3W421 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp... 53 6e-06
UniRef50_Q12FH4 Cluster: Pyruvate dehydrogenase; n=37; Bacteria|... 52 8e-06
UniRef50_Q1AZ54 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacte... 52 1e-05
UniRef50_A7K3C9 Cluster: Dehydrogenase E1 component superfamily;... 52 1e-05
UniRef50_A3RZM3 Cluster: Pyruvate dehydrogenase E1 component alp... 52 1e-05
UniRef50_Q5SJR9 Cluster: Pyruvate dehydrogenase (Lipoamide) (EC ... 51 2e-05
UniRef50_A0JY23 Cluster: Pyruvate dehydrogenase; n=2; Arthrobact... 51 3e-05
UniRef50_Q4MTG0 Cluster: Pyruvate dehydrogenase E1 component sub... 51 3e-05
UniRef50_A6WG12 Cluster: Pyruvate dehydrogenase; n=3; Actinomyce... 50 3e-05
UniRef50_A7CXZ4 Cluster: Pyruvate dehydrogenase; n=1; Opitutacea... 50 4e-05
UniRef50_Q83DQ6 Cluster: Dehydrogenase, E1 component, alpha subu... 50 6e-05
UniRef50_Q479Q2 Cluster: Dehydrogenase, E1 component; n=2; Rhodo... 49 8e-05
UniRef50_Q53610 Cluster: Branched-chain alpha-keto acid dehydrog... 49 1e-04
UniRef50_Q67SE7 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 48 1e-04
UniRef50_Q49108 Cluster: Pyruvate dehydrogenase EI alpha subunit... 48 1e-04
UniRef50_A4F1Y5 Cluster: Branched-chain alpha-keto acid decarbox... 48 2e-04
UniRef50_A5IXN2 Cluster: Pyruvate dehydrogenase E1 component, al... 47 4e-04
UniRef50_Q1XDM0 Cluster: Pyruvate dehydrogenase E1 component sub... 46 5e-04
UniRef50_A0LFE6 Cluster: Pyruvate dehydrogenase; n=1; Syntrophob... 46 7e-04
UniRef50_Q1IY28 Cluster: Pyruvate dehydrogenase; n=1; Deinococcu... 46 0.001
UniRef50_Q5VGY4 Cluster: Pyruvate dehydrogenase alpha subunit; n... 46 0.001
UniRef50_Q8D6Q7 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 45 0.001
UniRef50_Q83FF2 Cluster: Pyruvate dehydrogenase E1 component alp... 45 0.001
UniRef50_Q74AD3 Cluster: Dehydrogenase complex, E1 component, al... 45 0.001
UniRef50_Q3DYK5 Cluster: Dehydrogenase, E1 component; n=3; Bacte... 45 0.001
UniRef50_A6DTS3 Cluster: Dehydrogenase complex, E1 component, al... 45 0.001
UniRef50_Q1KSF1 Cluster: Apicoplast pyruvate dehydrogenase E1 al... 45 0.001
UniRef50_Q7NLM8 Cluster: Gll1094 protein; n=1; Gloeobacter viola... 45 0.002
UniRef50_A4VXG8 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 45 0.002
UniRef50_A0LTQ9 Cluster: Pyruvate dehydrogenase; n=1; Acidotherm... 45 0.002
UniRef50_A0LSF3 Cluster: Pyruvate dehydrogenase; n=5; Bacteria|R... 44 0.003
UniRef50_P16387 Cluster: Pyruvate dehydrogenase E1 component sub... 44 0.003
UniRef50_Q1EGI2 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 44 0.004
UniRef50_Q9HNV6 Cluster: Pyruvate dehydrogenase alpha subunit; n... 44 0.004
UniRef50_Q6MAE2 Cluster: Putative pyruvate dehydrogenase (Lipoam... 43 0.005
UniRef50_A2QWB4 Cluster: Catalytic activity: Pyruvate + Lipoamid... 43 0.007
UniRef50_Q8AB00 Cluster: 2-oxoisovalerate dehydrogenase beta sub... 42 0.009
UniRef50_Q1ARM0 Cluster: Pyruvate dehydrogenase; n=3; Bacteria|R... 42 0.009
UniRef50_Q8SQM8 Cluster: PYRUVATE DEHYDROGENASE E1 COMPONENT ALP... 42 0.009
UniRef50_Q8PQ82 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 42 0.015
UniRef50_Q6A611 Cluster: Pyruvate dehydrogenase E1 component, al... 42 0.015
UniRef50_O96865 Cluster: Pyruvate dehydrogenase E1 alpha subunit... 41 0.027
UniRef50_Q13GQ3 Cluster: Putative 2-oxo acid dehydrogenase alpha... 40 0.036
UniRef50_Q2JA37 Cluster: Pyruvate dehydrogenase; n=11; Actinomyc... 40 0.047
UniRef50_Q2BFQ9 Cluster: Putative uncharacterized protein; n=1; ... 40 0.047
UniRef50_Q6NX32 Cluster: Pyruvate dehydrogenase (Lipoamide) alph... 39 0.082
UniRef50_A4X7T3 Cluster: Dehydrogenase, E1 component; n=3; Actin... 39 0.082
UniRef50_Q5LVW0 Cluster: Dehydrogenase/transketolase family prot... 38 0.25
UniRef50_A6GG24 Cluster: Pyruvate dehydrogenase (Lipoamide), alp... 38 0.25
UniRef50_UPI0000E4A5CB Cluster: PREDICTED: hypothetical protein,... 37 0.33
UniRef50_Q4T3C0 Cluster: Chromosome undetermined SCAF10102, whol... 37 0.44
UniRef50_Q1ATM5 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacte... 37 0.44
UniRef50_Q97YF6 Cluster: Pyruvate dehydrogenase, alpha subunit (... 36 0.58
UniRef50_Q8H1Y0 Cluster: Pyruvate dehydrogenase E1 component sub... 36 0.77
UniRef50_A6UDY5 Cluster: Dehydrogenase E1 component; n=2; Alphap... 35 1.3
UniRef50_P08559 Cluster: Pyruvate dehydrogenase E1 component sub... 35 1.3
UniRef50_Q4Z3X1 Cluster: Putative uncharacterized protein; n=4; ... 35 1.8
UniRef50_Q5FNM5 Cluster: Pyruvate dehydrogenase E1 component alp... 34 2.3
UniRef50_Q2ITF8 Cluster: Acetoin dehydrogenase (TPP-dependent) a... 34 3.1
UniRef50_Q2AD68 Cluster: Putative uncharacterized protein; n=1; ... 34 3.1
UniRef50_A7BPK6 Cluster: Pyruvate dehydrogenase; n=1; Beggiatoa ... 34 3.1
UniRef50_Q5DY55 Cluster: Putative uncharacterized protein; n=1; ... 33 4.1
UniRef50_Q2S150 Cluster: Pyruvate dehydrogenase E1 component, al... 33 4.1
UniRef50_Q0ET31 Cluster: Dehydrogenase, E1 component; n=1; Therm... 33 4.1
UniRef50_A6Q3I6 Cluster: Pyruvate/2-oxoglutarate dehydrogenase c... 33 4.1
UniRef50_A3ZN48 Cluster: Putative uncharacterized protein; n=1; ... 33 4.1
UniRef50_Q4QDQ1 Cluster: Pyruvate dehydrogenase E1 component alp... 33 4.1
UniRef50_Q9R9N5 Cluster: Pyruvate dehydrogenase E1 component sub... 33 4.1
UniRef50_Q0RVK8 Cluster: Probable pyruvate dehydrogenase; n=1; R... 33 5.4
UniRef50_A2TU24 Cluster: (Pyruvate) Oxoisovalerate Dehydrogenase... 33 5.4
UniRef50_Q630X8 Cluster: Hypothetical and glycosyltransferase fu... 33 7.1
UniRef50_A4XF89 Cluster: Dehydrogenase, E1 component; n=1; Novos... 33 7.1
UniRef50_A3PXW7 Cluster: Transketolase domain protein; n=4; Myco... 33 7.1
UniRef50_UPI0000E0F4CE Cluster: co-chaperone HscB; n=1; alpha pr... 32 9.4
UniRef50_Q7RL33 Cluster: Putative uncharacterized protein PY0271... 32 9.4
UniRef50_P31334 Cluster: 54S ribosomal protein L9, mitochondrial... 32 9.4
UniRef50_O14618 Cluster: Copper chaperone for superoxide dismuta... 32 9.4
UniRef50_Q7TMA5 Cluster: Apolipoprotein B-100 precursor (Apo B-1... 32 9.4
>UniRef50_Q9VHB8 Cluster: CG8199-PA; n=2; Eukaryota|Rep: CG8199-PA -
Drosophila melanogaster (Fruit fly)
Length = 439
Score = 211 bits (515), Expect = 1e-53
Identities = 92/158 (58%), Positives = 120/158 (75%)
Frame = +1
Query: 139 AEFPGARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQ 318
A FPGA+AP+VS++ Y PIPIYRVMD +G I D+ ++P L + + M++ MV
Sbjct: 44 ANFPGAKAPFVSKLNLIQPEDYAPIPIYRVMDQDGYIADETQDPQLGREVVEKMFRDMVL 103
Query: 319 LSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTV 498
L+ MDKILYESQRQGRISFYMTN+GEE HIGSA+AL +DL++ QYRE GV ++RG +
Sbjct: 104 LNTMDKILYESQRQGRISFYMTNFGEEASHIGSAAALEMRDLIYGQYREAGVLVWRGFRI 163
Query: 499 TELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTISSPL 612
+ ++QCYGN +D G+G+QMPVHYGS+ N VTISSPL
Sbjct: 164 DQFIDQCYGNTDDLGRGKQMPVHYGSRELNFVTISSPL 201
>UniRef50_Q295J7 Cluster: GA20891-PA; n=7; Coelomata|Rep: GA20891-PA
- Drosophila pseudoobscura (Fruit fly)
Length = 439
Score = 209 bits (510), Expect = 5e-53
Identities = 92/158 (58%), Positives = 121/158 (76%)
Frame = +1
Query: 139 AEFPGARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQ 318
A FPGA+AP+VS++K Y PIPIYRVMD +G I D+ ++P L + + M++ M+
Sbjct: 44 ANFPGAKAPFVSKLKLNMPEDYAPIPIYRVMDRDGFIADETQDPQLGREVVEKMFRDMLL 103
Query: 319 LSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTV 498
L+ MDKILYESQRQGRISFYMTN+GEE HIGSA+AL +DL++ QYRE GV ++RG +
Sbjct: 104 LNTMDKILYESQRQGRISFYMTNFGEEASHIGSAAALEMRDLIYGQYREAGVLVWRGFRI 163
Query: 499 TELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTISSPL 612
+ ++QCYGN +D G+G+QMPVHYGS+ N VTISSPL
Sbjct: 164 DQFIDQCYGNVDDLGRGKQMPVHYGSRELNFVTISSPL 201
>UniRef50_P12694 Cluster: 2-oxoisovalerate dehydrogenase subunit
alpha, mitochondrial precursor; n=29; Euteleostomi|Rep:
2-oxoisovalerate dehydrogenase subunit alpha,
mitochondrial precursor - Homo sapiens (Human)
Length = 445
Score = 204 bits (498), Expect = 1e-51
Identities = 93/157 (59%), Positives = 115/157 (73%)
Frame = +1
Query: 142 EFPGARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQL 321
+FPGA A ++ +++F IPIYRVMD GQII+ +E+P+L K ++ +YK+M L
Sbjct: 53 QFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLL 112
Query: 322 SHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVT 501
+ MD+ILYESQRQGRISFYMTNYGEEG H+GSA+AL DLVF QYRE GV +YR +
Sbjct: 113 NTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYPLE 172
Query: 502 ELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTISSPL 612
+ QCYGN D GKGRQMPVHYG K + VTISSPL
Sbjct: 173 LFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPL 209
>UniRef50_Q4A1S8 Cluster: Putative uncharacterized protein; n=4;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 432
Score = 202 bits (493), Expect = 5e-51
Identities = 87/152 (57%), Positives = 117/152 (76%)
Frame = +1
Query: 157 RAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDK 336
+A + +++ N +PIYRV + G +IDK+++PN D+ T + MYKTM QL+ MD+
Sbjct: 42 KAAFTEKLEIVNADDTPALPIYRVTNAVGDVIDKSQDPNFDEQTSLKMYKTMTQLNIMDR 101
Query: 337 ILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQ 516
ILY+SQRQGRISFYMT++GEEG H+GSA+AL P+DL++ QYRE GV L+RG T+ +NQ
Sbjct: 102 ILYDSQRQGRISFYMTSFGEEGNHVGSAAALEPQDLIYGQYREAGVLLWRGYTMENFMNQ 161
Query: 517 CYGNCEDPGKGRQMPVHYGSKHHNMVTISSPL 612
CYGN +D GKGRQMP+H+G+K N VTISSPL
Sbjct: 162 CYGNADDLGKGRQMPMHFGTKERNFVTISSPL 193
>UniRef50_A7RZV6 Cluster: Predicted protein; n=6; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 444
Score = 189 bits (460), Expect = 5e-47
Identities = 88/158 (55%), Positives = 113/158 (71%), Gaps = 2/158 (1%)
Frame = +1
Query: 145 FPGA-RAPYVSEMKFFNETSYEPI-PIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQ 318
+PGA + +++F + + I P+YRVMD G+II + +P L + T+++MYK M
Sbjct: 50 YPGAMNCSFTEKLEFVDPMDPQGIIPVYRVMDRQGKIIIDSHDPKLPEGTIVDMYKKMTL 109
Query: 319 LSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTV 498
L+ MD+ILYESQRQGRISFYMTNYGEE H GSA+AL +DL+ QYRE GV ++RG T+
Sbjct: 110 LNTMDRILYESQRQGRISFYMTNYGEEATHFGSAAALEMEDLIMGQYREAGVLMWRGFTL 169
Query: 499 TELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTISSPL 612
+ +NQCY N D GKGRQMPVHYGSK N VTISS L
Sbjct: 170 ADFMNQCYANQHDAGKGRQMPVHYGSKELNFVTISSTL 207
>UniRef50_Q9LPL5 Cluster: Branched-chain alpha keto-acid
dehydrogenase E1-alpha subunit; n=13; Magnoliophyta|Rep:
Branched-chain alpha keto-acid dehydrogenase E1-alpha
subunit - Arabidopsis thaliana (Mouse-ear cress)
Length = 472
Score = 184 bits (447), Expect = 2e-45
Identities = 86/157 (54%), Positives = 109/157 (69%)
Frame = +1
Query: 142 EFPGARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQL 321
+FPG + Y SEMKF E+S IP YRV+D +G+II ++ + + + MY+ M L
Sbjct: 81 DFPGGKVGYTSEMKFIPESSSRRIPCYRVLDEDGRIIPDSDFIPVSEKLAVRMYEQMATL 140
Query: 322 SHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVT 501
MD I YE+QRQGRISFY+T+ GEE I+I SA+ALSP D+V QYRE GV L+RG T+
Sbjct: 141 QVMDHIFYEAQRQGRISFYLTSVGEEAINIASAAALSPDDVVLPQYREPGVLLWRGFTLE 200
Query: 502 ELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTISSPL 612
E NQC+GN D GKGRQMP+HYGS N TISSP+
Sbjct: 201 EFANQCFGNKADYGKGRQMPIHYGSNRLNYFTISSPI 237
>UniRef50_A0DAM1 Cluster: Chromosome undetermined scaffold_43, whole
genome shotgun sequence; n=3; Oligohymenophorea|Rep:
Chromosome undetermined scaffold_43, whole genome
shotgun sequence - Paramecium tetraurelia
Length = 406
Score = 159 bits (387), Expect = 4e-38
Identities = 72/138 (52%), Positives = 99/138 (71%)
Frame = +1
Query: 199 SYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFY 378
++EPI +RV+D G ++ K E N+ K L ++ M+ + MD +LY SQRQG+ISFY
Sbjct: 30 NFEPIKQFRVIDLEGNLVAK-EYNNIPKEILNQIFDLMISIEEMDNLLYMSQRQGKISFY 88
Query: 379 MTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQM 558
MT++GE +G+ +AL P+D +F QYRE G F++RG T+ ++VNQC GN D GKGRQM
Sbjct: 89 MTSFGETATTVGTTAALQPQDFIFPQYREQGSFMWRGFTIEQIVNQCIGNHLDGGKGRQM 148
Query: 559 PVHYGSKHHNMVTISSPL 612
PVHYGSK N+VT+SSPL
Sbjct: 149 PVHYGSKDLNIVTVSSPL 166
>UniRef50_A6RV39 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 211
Score = 155 bits (376), Expect = 8e-37
Identities = 76/162 (46%), Positives = 107/162 (66%), Gaps = 1/162 (0%)
Frame = +1
Query: 115 AQNGGGKIAEFPGA-RAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATL 291
+Q G FPGA + + S + F + ++Y IP YR M +G+I+D + D+A L
Sbjct: 43 SQKPGSAGVRFPGAVDSKFTSSLSFEHPSTYNAIPTYRTMSPDGEILDPSAVLPSDEAAL 102
Query: 292 INMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVG 471
MY M+++S MD I+ E+QRQGR+SFYM + GEEG +GSA+AL D++FSQYRE G
Sbjct: 103 -EMYLNMIKVSIMDVIMVEAQRQGRLSFYMPSQGEEGTCVGSAAALEKDDVIFSQYREAG 161
Query: 472 VFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVT 597
VF+ RG T+ E ++Q + N +D GK R MPVHYGSK N+V+
Sbjct: 162 VFMQRGFTLDEFMSQLFANRKDKGKARNMPVHYGSKELNIVS 203
>UniRef50_Q4DB65 Cluster: 2-oxoisovalerate dehydrogenase alpha
subunit, putative; n=3; Trypanosoma|Rep:
2-oxoisovalerate dehydrogenase alpha subunit, putative -
Trypanosoma cruzi
Length = 431
Score = 149 bits (360), Expect = 7e-35
Identities = 70/150 (46%), Positives = 101/150 (67%)
Frame = +1
Query: 163 PYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKIL 342
P V E+ F ++ Y P++ V+D +G++++ +EP + K TLI M + M++ +D IL
Sbjct: 45 PTVDELTF-HQRKYPSTPMFHVLDLDGRVVNPKQEPEVPKETLIKMMEAMLRQQSIDLIL 103
Query: 343 YESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCY 522
E+QRQGRISFYMT+ GEE +G+A+AL +D +F QYRE YRG TV ++V QC
Sbjct: 104 MEAQRQGRISFYMTSMGEEASAVGTAAALDMRDELFLQYREAAALTYRGYTVKDMVAQCM 163
Query: 523 GNCEDPGKGRQMPVHYGSKHHNMVTISSPL 612
G E+ KGRQMP+HYGS+ N+ ISSP+
Sbjct: 164 GTIENELKGRQMPIHYGSRALNVHMISSPV 193
>UniRef50_Q5KGR5 Cluster: Branched-chain alpha-keto acid
dehydrogenase E1-alpha subunit, putative; n=2;
Filobasidiella neoformans|Rep: Branched-chain alpha-keto
acid dehydrogenase E1-alpha subunit, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 504
Score = 142 bits (344), Expect = 6e-33
Identities = 68/148 (45%), Positives = 94/148 (63%), Gaps = 1/148 (0%)
Frame = +1
Query: 172 SEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYES 351
+EM +FN + + IP +RV+D G ++ E K +++Y+TM + +D +LY+S
Sbjct: 97 AEMGWFNAVA-KTIPTFRVLDEEGHMVKDGHESQATKEQTLSIYRTMTLIPIVDNVLYQS 155
Query: 352 QRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNC 531
QRQGRISFYM GEE +GSA+A+ D +F QYRE L+RG T+ L+ QC+GN
Sbjct: 156 QRQGRISFYMQCAGEEAAIVGSAAAMLANDEIFGQYRESAALLHRGFTLDALMAQCFGNV 215
Query: 532 EDPG-KGRQMPVHYGSKHHNMVTISSPL 612
+D G KGR MPVHY S H TI+SPL
Sbjct: 216 DDKGTKGRMMPVHYSSPEHGFHTITSPL 243
>UniRef50_Q4P2J0 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 786
Score = 141 bits (341), Expect = 1e-32
Identities = 70/143 (48%), Positives = 95/143 (66%), Gaps = 2/143 (1%)
Frame = +1
Query: 190 NETSYEPIPIYRVMDNNGQIID--KNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQG 363
N+ S IP YR+MD G+++ E N+ + + MY+TM+ L +D ILY +QRQG
Sbjct: 390 NKNSQGGIPTYRLMDGVGRLLPGVTQEMINITQQEAVKMYRTMLLLPQIDVILYNAQRQG 449
Query: 364 RISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPG 543
RISF MT+YGEEG IGSA+ L KD VF+QYRE GV L+R ++ ++Q +G +D
Sbjct: 450 RISFMMTSYGEEGAVIGSAAGLDAKDEVFAQYRESGVLLWRDFSIDHFMSQVFGAEDDLC 509
Query: 544 KGRQMPVHYGSKHHNMVTISSPL 612
GRQMP+H+GS H+ TISSPL
Sbjct: 510 GGRQMPIHFGSTQHHFHTISSPL 532
>UniRef50_Q4Y3F8 Cluster: Branched-chain alpha keto-acid
dehydrogenase, putative; n=7; Plasmodium|Rep:
Branched-chain alpha keto-acid dehydrogenase, putative -
Plasmodium chabaudi
Length = 432
Score = 138 bits (334), Expect = 1e-31
Identities = 67/151 (44%), Positives = 99/151 (65%), Gaps = 1/151 (0%)
Frame = +1
Query: 166 YVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILY 345
+ +++K NE + +PI+R++D NG ++D + P D ++N+YK MV+ S D+I Y
Sbjct: 48 FSTDLKTVNEVA--KLPIFRILDTNGNLLDGHTAP-FDDEEVLNLYKQMVEFSIWDEIFY 104
Query: 346 ESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYG 525
QRQGRISFY+ N GEEG+H G AL+ D ++ QYRE G+ L RG T +++NQ +G
Sbjct: 105 GIQRQGRISFYIVNDGEEGLHFGIGKALTVDDHLYCQYRETGILLSRGFTYEDILNQLFG 164
Query: 526 -NCEDPGKGRQMPVHYGSKHHNMVTISSPLG 615
+D GKGRQM + Y K N+ TI++PLG
Sbjct: 165 TKYDDEGKGRQMCICYTKKDLNIHTITTPLG 195
>UniRef50_Q5QUK4 Cluster: Alpha keto acid dehydrogenase complex, E1
component, alpha subunit; n=32; Gammaproteobacteria|Rep:
Alpha keto acid dehydrogenase complex, E1 component,
alpha subunit - Idiomarina loihiensis
Length = 395
Score = 131 bits (316), Expect = 1e-29
Identities = 63/149 (42%), Positives = 94/149 (63%)
Frame = +1
Query: 169 VSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYE 348
V++ K+F++ S IP+ +++ +G + P DK ++ ++ TM + +D+ +
Sbjct: 12 VTKPKWFDKDSVT-IPMLQILKEDGSFHKDADMPEYDKELIVKIHDTMQFIRILDERMIA 70
Query: 349 SQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGN 528
+QRQGRISFY+ + GEE + SA+AL D++ QYRE G YRG TV + +NQ + N
Sbjct: 71 AQRQGRISFYLASRGEEAESVASAAALDAGDMIMGQYREQGALAYRGFTVEQFMNQLFSN 130
Query: 529 CEDPGKGRQMPVHYGSKHHNMVTISSPLG 615
+D GKGRQMPVHYG N +TISSPLG
Sbjct: 131 EKDLGKGRQMPVHYGCADLNFMTISSPLG 159
>UniRef50_Q4QC52 Cluster: 2-oxoisovalerate dehydrogenase alpha
subunit, putative; n=3; Leishmania|Rep: 2-oxoisovalerate
dehydrogenase alpha subunit, putative - Leishmania major
Length = 479
Score = 128 bits (310), Expect = 8e-29
Identities = 58/105 (55%), Positives = 74/105 (70%)
Frame = +1
Query: 298 MYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVF 477
M M+ + MDKI+ E+QRQGRISFYMT +GEE IG+A+ L+ D +F+QYRE G+
Sbjct: 124 MMSAMLTHNTMDKIMLEAQRQGRISFYMTMFGEEAAVIGAAAGLASNDELFAQYREAGIL 183
Query: 478 LYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTISSPL 612
YRG T+ E + QC GNCE KGRQMP+HYGSK + +SSPL
Sbjct: 184 TYRGYTIPEFIAQCMGNCECDAKGRQMPIHYGSKRLHAQMVSSPL 228
>UniRef50_Q1KSF2 Cluster: Mitochondrial branched-chain alpha-keto
acid dehydrogenase E1; n=1; Toxoplasma gondii|Rep:
Mitochondrial branched-chain alpha-keto acid
dehydrogenase E1 - Toxoplasma gondii
Length = 463
Score = 118 bits (284), Expect = 1e-25
Identities = 61/149 (40%), Positives = 86/149 (57%)
Frame = +1
Query: 166 YVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILY 345
+ ++M NET IPI+R++D +GQI D + P + ++ Y+ MV+LS D + Y
Sbjct: 78 FTTDMNISNETPV--IPIFRILDYDGQIADGWQCP-MTNDEVLEAYQFMVKLSIWDNMFY 134
Query: 346 ESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYG 525
QRQGRISFY+ N GEE + AL KD +F QYRE+GV + G T + + Q +
Sbjct: 135 SVQRQGRISFYIQNQGEEALQTAVGLALDKKDHLFCQYRELGVLMLHGFTAEDALEQLFA 194
Query: 526 NCEDPGKGRQMPVHYGSKHHNMVTISSPL 612
D KGRQMP+ Y N+ TI +PL
Sbjct: 195 RRGDESKGRQMPISYSKHSVNLHTICTPL 223
>UniRef50_Q4N1L6 Cluster: Branched-chain alpha keto-acid
dehydrogenase, putative; n=3; Piroplasmida|Rep:
Branched-chain alpha keto-acid dehydrogenase, putative -
Theileria parva
Length = 464
Score = 105 bits (251), Expect = 1e-21
Identities = 55/149 (36%), Positives = 85/149 (57%), Gaps = 10/149 (6%)
Frame = +1
Query: 196 TSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISF 375
T + +PI++VM +G + + ++ P + + MV+L+ D + Y QRQGRISF
Sbjct: 75 TDSQVMPIFQVMKTDGTLHEGHKSPFESDEKVKEYLQIMVKLNVWDNLFYNIQRQGRISF 134
Query: 376 YMTNYGEEGIHIGSASALSPKDLVFSQY----------REVGVFLYRGMTVTELVNQCYG 525
Y+ N GEE +G+ AL P+D +F QY RE+GV +G T +++ Q +
Sbjct: 135 YIQNQGEEATQLGAGLALQPQDHLFCQYRYFTKDYKNFRELGVIYVKGCTEDDVLAQLFS 194
Query: 526 NCEDPGKGRQMPVHYGSKHHNMVTISSPL 612
+D GKGRQMP+ Y K N+ TI++PL
Sbjct: 195 THKDEGKGRQMPISYSKKEVNLHTITTPL 223
>UniRef50_A7HBV0 Cluster: 3-methyl-2-oxobutanoate dehydrogenase;
n=4; Cystobacterineae|Rep: 3-methyl-2-oxobutanoate
dehydrogenase - Anaeromyxobacter sp. Fw109-5
Length = 399
Score = 104 bits (249), Expect = 2e-21
Identities = 50/133 (37%), Positives = 78/133 (58%)
Frame = +1
Query: 214 PIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYG 393
P+YR++ +G+++ +E L A ++ +Y+ MV +D+ + QRQGRI FY+ + G
Sbjct: 31 PLYRLVAEDGELVGAPDEVTLPDAEVLRLYRLMVLNRSLDERMITLQRQGRIGFYIGSIG 90
Query: 394 EEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYG 573
EE +GSA+A++ D +F YRE G L RGM + + +GN D KGRQMP H
Sbjct: 91 EEATILGSAAAMAESDWIFPCYREHGAALMRGMPLVTFLCDLFGNAGDAMKGRQMPCHEA 150
Query: 574 SKHHNMVTISSPL 612
+ +ISSP+
Sbjct: 151 WRPGRFTSISSPI 163
>UniRef50_Q9YBC0 Cluster: Pyruvate dehydrogenase E1 component, alpha
subunit; n=1; Aeropyrum pernix|Rep: Pyruvate
dehydrogenase E1 component, alpha subunit - Aeropyrum
pernix
Length = 377
Score = 95.1 bits (226), Expect = 1e-18
Identities = 41/131 (31%), Positives = 77/131 (58%)
Frame = +1
Query: 223 RVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEG 402
R +D G+++D+ P + + ++ +Y MV+ +D L + QR G+++ + N G+E
Sbjct: 16 RAVDEEGRVVDEELLPKVSEGEIVEIYTYMVRARVIDSWLLKLQRMGKVALHAPNKGQEA 75
Query: 403 IHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKH 582
+ +G+A L D VF YRE+G +L RGM+ E++++ N +DP KG + +G++
Sbjct: 76 VAVGAAKPLRRDDWVFPSYRELGAYLVRGMSEEEILDRALANADDPLKGSDFAI-FGNRK 134
Query: 583 HNMVTISSPLG 615
+N+V P+G
Sbjct: 135 YNLVPAPVPVG 145
>UniRef50_Q6YPX5 Cluster: Thiamine pyrophosphate-dependent
dehydrogenase, E1 component alpha subunit; n=2;
Candidatus Phytoplasma asteris|Rep: Thiamine
pyrophosphate-dependent dehydrogenase, E1 component
alpha subunit - Onion yellows phytoplasma
Length = 363
Score = 93.9 bits (223), Expect = 3e-18
Identities = 44/111 (39%), Positives = 66/111 (59%), Gaps = 2/111 (1%)
Frame = +1
Query: 202 YEPIP--IYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISF 375
Y+P+ ++++D NG ++ EP L K L+ MYKTMV D + QRQGR+
Sbjct: 6 YDPLKGKQFQILDENGNLVQPELEPKLSKDVLLKMYKTMVLGRQADLAALKYQRQGRMGN 65
Query: 376 YMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGN 528
Y+ N G+E +G A+AL P+D V YR+ G+FLYRG+++ + YGN
Sbjct: 66 YLLNSGQEASQVGVAAALEPQDWVSPYYRDAGIFLYRGVSLEQFYLYWYGN 116
>UniRef50_Q97CK0 Cluster: 2-oxoisovalerate dehydrogenase alpha
subunit; n=2; Thermoplasma|Rep: 2-oxoisovalerate
dehydrogenase alpha subunit - Thermoplasma volcanium
Length = 337
Score = 92.7 bits (220), Expect = 6e-18
Identities = 43/111 (38%), Positives = 66/111 (59%)
Frame = +1
Query: 280 KATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQY 459
K+ + + +MV DK + +QRQG + FY G+E G+A ALS +DLV+ Y
Sbjct: 10 KSLYVKGFTSMVLGRLFDKKVITAQRQGLVGFYTPMMGQEATQAGAAMALSKQDLVYGYY 69
Query: 460 REVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTISSPL 612
R+V + +Y G + ++ +Q GN ED KGRQMP HY +K N +++ SP+
Sbjct: 70 RDVTLLIYLGYPIEKIFDQIMGNAEDTSKGRQMPSHYSAKAVNFMSVPSPV 120
>UniRef50_P35485 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=2; Firmicutes|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Acholeplasma
laidlawii
Length = 345
Score = 81.0 bits (191), Expect = 2e-14
Identities = 40/99 (40%), Positives = 56/99 (56%)
Frame = +1
Query: 232 DNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHI 411
D NG+++++ EP L K TL+ MYKT V + D + QRQGR+ Y N G+E I
Sbjct: 1 DQNGKVVNEKMEPKLPKETLLKMYKTAVLGRNADIKALQYQRQGRMLTYAPNMGQEAAQI 60
Query: 412 GSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGN 528
G A+A+ P+D YRE+ LYRG + + YGN
Sbjct: 61 GMAAAMEPQDWNSPMYRELNTLLYRGDKLENVFLYWYGN 99
>UniRef50_P09060 Cluster: 2-oxoisovalerate dehydrogenase subunit
alpha; n=68; Proteobacteria|Rep: 2-oxoisovalerate
dehydrogenase subunit alpha - Pseudomonas putida
Length = 410
Score = 79.8 bits (188), Expect = 5e-14
Identities = 44/132 (33%), Positives = 69/132 (52%)
Frame = +1
Query: 217 IYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGE 396
+ RV+D G E ++D L + M++ D + +QRQ ++SFYM + GE
Sbjct: 54 LVRVLDEQGDAQGPWAE-DIDPQILRQGMRAMLKTRIFDSRMVVAQRQKKMSFYMQSLGE 112
Query: 397 EGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGS 576
E I G A AL+ D+ F YR+ + + R +++ E++ Q N DP KGRQ+P+ Y
Sbjct: 113 EAIGSGQALALNRTDMCFPTYRQQSILMARDVSLVEMICQLLSNERDPLKGRQLPIMYSV 172
Query: 577 KHHNMVTISSPL 612
+ TIS L
Sbjct: 173 REAGFFTISGNL 184
>UniRef50_P37940 Cluster: 2-oxoisovalerate dehydrogenase subunit
alpha; n=37; Firmicutes|Rep: 2-oxoisovalerate
dehydrogenase subunit alpha - Bacillus subtilis
Length = 330
Score = 79.8 bits (188), Expect = 5e-14
Identities = 42/122 (34%), Positives = 70/122 (57%), Gaps = 2/122 (1%)
Frame = +1
Query: 253 DKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALS 432
++++ L ++MY+TM+ +D+ ++ R G+I F ++ G+E +G+A AL
Sbjct: 4 NRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPFVISCQGQEAAQVGAAFALD 63
Query: 433 PK-DLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGK-GRQMPVHYGSKHHNMVTISS 606
+ D V YR++GV L GMT +L+ + DP GRQMP H+G K + +VT SS
Sbjct: 64 REMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNSGGRQMPGHFGQKKNRIVTGSS 123
Query: 607 PL 612
P+
Sbjct: 124 PV 125
>UniRef50_Q9RPS5 Cluster: TPP-dependent branched-chain alpha-keto
acid dehydrogenase, E1 alpha subunit; n=3;
Lactobacillales|Rep: TPP-dependent branched-chain
alpha-keto acid dehydrogenase, E1 alpha subunit -
Enterococcus faecalis (Streptococcus faecalis)
Length = 330
Score = 77.4 bits (182), Expect = 3e-13
Identities = 42/117 (35%), Positives = 65/117 (55%), Gaps = 2/117 (1%)
Frame = +1
Query: 262 EEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSP-K 438
++ L K LI Y+ +++ +D+ L++ R G+ SF ++ G E + A A +P K
Sbjct: 7 KKSGLSKEELIQAYRQVLRGRRLDERLWQLTRIGKTSFNISGQGAEVAQVAMAMAFNPQK 66
Query: 439 DLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGK-GRQMPVHYGSKHHNMVTISS 606
D YR++ L GMT +++ +G DP GRQMP HYGSK HN+V+ SS
Sbjct: 67 DYFLPYYRDMTACLVWGMTSKDILMGSFGKEADPSSHGRQMPNHYGSKEHNIVSFSS 123
>UniRef50_O48615 Cluster: Alpha-keto acid dehydrogenase-like
protein; n=21; Eukaryota|Rep: Alpha-keto acid
dehydrogenase-like protein - Hordeum vulgare (Barley)
Length = 64
Score = 77.0 bits (181), Expect = 3e-13
Identities = 36/64 (56%), Positives = 44/64 (68%)
Frame = +1
Query: 421 SALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTI 600
+ALS +D+V QYRE GV L+RG T+ E NQ +GN D GKGRQMP+HYGS N+ T
Sbjct: 1 AALSAQDIVLPQYREPGVLLWRGFTLQEFANQLFGNNLDYGKGRQMPIHYGSNRLNLFTR 60
Query: 601 SSPL 612
S L
Sbjct: 61 SHRL 64
>UniRef50_Q9HN77 Cluster: Pyruvate dehydrogenase alpha subunit; n=8;
Halobacteriaceae|Rep: Pyruvate dehydrogenase alpha
subunit - Halobacterium salinarium (Halobacterium
halobium)
Length = 419
Score = 75.8 bits (178), Expect = 8e-13
Identities = 39/99 (39%), Positives = 53/99 (53%)
Frame = +1
Query: 208 PIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTN 387
P YRV+D NG+++D E P+L L+ MY+ M D+ QRQGRI Y
Sbjct: 57 PDDTYRVLDENGELVDGAEVPDLTDDELVEMYRYMKLARRFDERAVSLQRQGRIGTYPPL 116
Query: 388 YGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTE 504
G+EG I SA AL+ D + YRE G L RG+ + +
Sbjct: 117 SGQEGAQIASAMALADDDWIVPSYREHGASLVRGLPLKD 155
>UniRef50_Q9RYC1 Cluster: 2-oxo acid dehydrogenase, E1 component,
alpha subunit; n=2; Deinococcus|Rep: 2-oxo acid
dehydrogenase, E1 component, alpha subunit - Deinococcus
radiodurans
Length = 381
Score = 73.7 bits (173), Expect = 3e-12
Identities = 41/111 (36%), Positives = 62/111 (55%), Gaps = 1/111 (0%)
Frame = +1
Query: 283 ATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASAL-SPKDLVFSQY 459
A L +++ M+Q D+ L RQGR SFY G E IG A A+ + D V+ Y
Sbjct: 43 ALLRELHRLMLQGREFDRKLITLLRQGRTSFYSQASGMEATQIGLAKAIRAGHDWVWGYY 102
Query: 460 REVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTISSPL 612
R+ + + G+ + L++QC G+ D +GRQMP H+ S+ HN V+ SS +
Sbjct: 103 RDQVLGMGLGVPMFTLISQCLGSNTDECRGRQMPHHFSSRAHNFVSASSSI 153
>UniRef50_Q020J5 Cluster: Dehydrogenase, E1 component; n=1;
Solibacter usitatus Ellin6076|Rep: Dehydrogenase, E1
component - Solibacter usitatus (strain Ellin6076)
Length = 697
Score = 72.5 bits (170), Expect = 7e-12
Identities = 39/111 (35%), Positives = 61/111 (54%), Gaps = 2/111 (1%)
Frame = +1
Query: 289 LINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSP-KDLVFSQYRE 465
LI ++ M +D +RQ RI F ++ G E + + +A +L P +D V+ YR+
Sbjct: 22 LIRAFRIMHTARRLDDREIALKRQNRIFFQISGAGHEAVQVAAAMSLRPGRDWVYPYYRD 81
Query: 466 VGVFLYRGMTVTELVNQCYGNCEDPGKG-RQMPVHYGSKHHNMVTISSPLG 615
+ L G+T E++ Q G DP G RQMP H+G+ +N+V+ SSP G
Sbjct: 82 RALCLALGVTPLEMLQQAVGAAADPASGGRQMPSHWGNAAYNIVSSSSPTG 132
>UniRef50_Q72GU1 Cluster: 2-oxoisovalerate dehydrogenase subunit
alpha; n=2; Thermus thermophilus|Rep: 2-oxoisovalerate
dehydrogenase subunit alpha - Thermus thermophilus
(strain HB27 / ATCC BAA-163 / DSM 7039)
Length = 367
Score = 70.9 bits (166), Expect = 2e-11
Identities = 49/149 (32%), Positives = 72/149 (48%), Gaps = 1/149 (0%)
Frame = +1
Query: 169 VSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYE 348
V E F + EPI R++ G+ + + +L+ L +Y+ M+ +D+
Sbjct: 2 VKETHRFEPFTEEPI---RLIGEEGEWLG-DFPLDLEGEKLRRLYRDMLAARMLDERYTI 57
Query: 349 SQRQGRISFYMTNYGEEGIHIGSASALSPK-DLVFSQYREVGVFLYRGMTVTELVNQCYG 525
R G+ SF G E + A A+ P D VF YR+ G+ L G+ + EL Q
Sbjct: 58 LIRTGKTSFIAPAAGHEAAQVAIAHAIRPGFDWVFPYYRDHGLALALGIPLKELFGQMLA 117
Query: 526 NCEDPGKGRQMPVHYGSKHHNMVTISSPL 612
DP KGRQMP H GSK N T++SP+
Sbjct: 118 TKADPNKGRQMPEHPGSKALNFFTVASPI 146
>UniRef50_A0M1U4 Cluster: 2-oxoisovalerate dehydrogenase E1
component subunits alpha and beta; n=18;
Bacteroidetes|Rep: 2-oxoisovalerate dehydrogenase E1
component subunits alpha and beta - Gramella forsetii
(strain KT0803)
Length = 685
Score = 68.1 bits (159), Expect = 2e-10
Identities = 37/145 (25%), Positives = 74/145 (51%), Gaps = 1/145 (0%)
Frame = +1
Query: 184 FFNETSYEPIPIYRVMDNNGQIIDKN-EEPNLDKATLINMYKTMVQLSHMDKILYESQRQ 360
FF+ + Y ++ NN + +E L ++++Y++M++ +++ + RQ
Sbjct: 4 FFSLECFTDKQNYFMLSNNTKSRTMEYKETQLSNDAMLDLYRSMLKPRMIEEKMLILLRQ 63
Query: 361 GRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDP 540
G+IS + + G+E I +G +L ++ + +R +GVF R + + L Q G
Sbjct: 64 GKISKWFSGIGQEAISVGVTKSLETEEYILPMHRNLGVFTSREIPLNRLFAQWQGKASGF 123
Query: 541 GKGRQMPVHYGSKHHNMVTISSPLG 615
KGR H+G++ +N+V + S LG
Sbjct: 124 TKGRDRSFHFGTQEYNIVGMISHLG 148
>UniRef50_Q5KUY4 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
alpha subunit; n=2; Geobacillus|Rep: Pyruvate
dehydrogenase E1 (Lipoamide) alpha subunit - Geobacillus
kaustophilus
Length = 359
Score = 67.7 bits (158), Expect = 2e-10
Identities = 41/118 (34%), Positives = 58/118 (49%)
Frame = +1
Query: 208 PIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTN 387
P+ I R++D NG D+ + L+ Y+ M + +D+ L QRQGRI Y
Sbjct: 8 PVEIVRILDENGNG-DEEKLAAFSDEWLLRAYREMRRARVIDERLLRMQRQGRIGTYAPF 66
Query: 388 YGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMP 561
G+E IGSA AL D +F YREV V L GM + + + G G++MP
Sbjct: 67 SGQEAAQIGSALALHKDDWIFPSYREVAVCLMHGMPLEQFFHYVQGRL----SGKRMP 120
>UniRef50_Q8CX87 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
alpha subunit; n=5; Bacillaceae|Rep: Pyruvate
dehydrogenase E1 (Lipoamide) alpha subunit -
Oceanobacillus iheyensis
Length = 358
Score = 66.5 bits (155), Expect = 5e-10
Identities = 39/117 (33%), Positives = 58/117 (49%), Gaps = 3/117 (2%)
Frame = +1
Query: 205 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 384
E P+ R+MD NG+I D + +DKA + Y+ ++ + D+ QRQGRI Y
Sbjct: 7 EEFPMIRIMDQNGKITDTSYLEQIDKALVQQFYRQLICMRAFDQKAINLQRQGRIGTYPG 66
Query: 385 NYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVN---QCYGNCEDPGK 546
G+EG +GSA AL D + YR+ + G + T L + + GN GK
Sbjct: 67 FEGQEGAQVGSALALDEDDWMLPTYRDHAASITFGKSYTILSSWNGRVEGNLPPEGK 123
>UniRef50_Q67ME6 Cluster: Branched-chain alpha-keto acid
dehydrogenase E1 alpha subunit; n=23; Bacteria|Rep:
Branched-chain alpha-keto acid dehydrogenase E1 alpha
subunit - Symbiobacterium thermophilum
Length = 352
Score = 65.7 bits (153), Expect = 8e-10
Identities = 39/121 (32%), Positives = 66/121 (54%), Gaps = 2/121 (1%)
Frame = +1
Query: 256 KNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSP 435
++E L + MY M+ +D+ L+ QR G+I F ++ G+E +G+A A
Sbjct: 26 RHEALGLTADQVREMYYYMLLTRRLDERLWLLQRGGKIPFVISPQGQEAAQVGAAFAFRR 85
Query: 436 K-DLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGK-GRQMPVHYGSKHHNMVTISSP 609
+ D YR++GV L G+T E++ + DP G+QMP H+G++ N+V+ SSP
Sbjct: 86 RQDWFTPYYRDLGVNLVVGVTPREVMLSAFARGADPASGGKQMPSHWGNRPLNIVSGSSP 145
Query: 610 L 612
+
Sbjct: 146 V 146
>UniRef50_Q1IQR3 Cluster: Dehydrogenase, E1 component; n=1;
Acidobacteria bacterium Ellin345|Rep: Dehydrogenase, E1
component - Acidobacteria bacterium (strain Ellin345)
Length = 736
Score = 64.5 bits (150), Expect = 2e-09
Identities = 42/124 (33%), Positives = 61/124 (49%), Gaps = 2/124 (1%)
Frame = +1
Query: 250 IDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASAL 429
++K E L + L+ Y+ M +D +RQ R+ F ++ G E + + + L
Sbjct: 18 VNKTYE-GLTREDLLRAYRLMYLSRRIDDREILLKRQQRVFFQISGAGHEAMLVAAGLLL 76
Query: 430 SPK-DLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKG-RQMPVHYGSKHHNMVTIS 603
P D F YR+ + L GMT E++ G DP G RQMP H+G K N+VT S
Sbjct: 77 KPGYDWFFPYYRDRALCLALGMTAEEMLLGAVGAAADPNSGGRQMPSHWGHKGLNIVTGS 136
Query: 604 SPLG 615
SP G
Sbjct: 137 SPTG 140
>UniRef50_A6CP23 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
alpha subunit; n=2; Bacillus sp. SG-1|Rep: Pyruvate
dehydrogenase E1 (Lipoamide) alpha subunit - Bacillus
sp. SG-1
Length = 364
Score = 64.5 bits (150), Expect = 2e-09
Identities = 33/106 (31%), Positives = 57/106 (53%)
Frame = +1
Query: 193 ETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRIS 372
E E PI R++DN+G ++ +++P + + Y+ MV++ DK QRQGRI
Sbjct: 9 EEMEEQFPIKRIIDNDGTLLG-DKDPGITEQLAKEFYRHMVRIRTFDKKAISLQRQGRIG 67
Query: 373 FYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELV 510
Y G+E +GS++AL D +F YR+ G + G ++ ++
Sbjct: 68 TYAPFEGQEASQVGSSAALKEDDWMFPSYRDHGAAMTFGHSLRNIL 113
>UniRef50_P47516 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=5; Mycoplasma|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Mycoplasma
genitalium
Length = 358
Score = 64.5 bits (150), Expect = 2e-09
Identities = 39/121 (32%), Positives = 58/121 (47%)
Frame = +1
Query: 208 PIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTN 387
P +Y+V DN G++ID N + L L + Y M MDK + QR G++ + N
Sbjct: 10 PTTLYQVYDNEGKLIDPNHKITLTDEQLKHAYYLMNLSRMMDKKMLVWQRAGKMLNFAPN 69
Query: 388 YGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVH 567
GEE + +G L+ D V +R + LYRG+ +L+ GN KG Q+
Sbjct: 70 LGEEALQVGMGLGLNENDWVCPTFRSGALMLYRGVKPEQLLLYWNGN----EKGSQIDAK 125
Query: 568 Y 570
Y
Sbjct: 126 Y 126
>UniRef50_Q4L1A7 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=9; Mycoplasma|Rep: Pyruvate dehydrogenase E1
component alpha subunit - Mycoplasma synoviae
Length = 374
Score = 64.1 bits (149), Expect = 3e-09
Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 1/109 (0%)
Frame = +1
Query: 205 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 384
+P + RV+D NG +IDK +P L L+ YK MV D + + QRQGR+ +
Sbjct: 20 DPSKLIRVLDVNGNLIDKKYKPQLTDKQLVEGYKWMVLSRQQDTYMLQLQRQGRMLTFAP 79
Query: 385 NYGEEGIHIGSASAL-SPKDLVFSQYREVGVFLYRGMTVTELVNQCYGN 528
N GEE + + +A AL KD +R L G+ + + GN
Sbjct: 80 NLGEEALQVATAFALDKKKDWFLPAFRSNATMLALGVPMVNQMLYWNGN 128
>UniRef50_A5UU15 Cluster: Pyruvate dehydrogenase; n=3; Chloroflexi
(class)|Rep: Pyruvate dehydrogenase - Roseiflexus sp.
RS-1
Length = 350
Score = 62.1 bits (144), Expect = 1e-08
Identities = 32/111 (28%), Positives = 57/111 (51%), Gaps = 1/111 (0%)
Frame = +1
Query: 259 NEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSP 435
+ + LD ATLI+ Y+ MV + ++ E + +I ++ Y GEE +G+ +AL P
Sbjct: 16 SNDSGLDAATLIDYYRQMVLIRRFEEKCQEMYTRAKIGGFLHLYIGEEATAVGAIAALRP 75
Query: 436 KDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHN 588
D +F+ YR+ G + RG+ + L+ + +G KG +H+ N
Sbjct: 76 DDHIFTHYRDHGHAIARGLDINALMAELFGKVTGCSKGLGGSMHFADASKN 126
>UniRef50_Q0W151 Cluster: Pyruvate dehydrogenase complex E1,
transketolase alpha subunit; n=1; uncultured
methanogenic archaeon RC-I|Rep: Pyruvate dehydrogenase
complex E1, transketolase alpha subunit - Uncultured
methanogenic archaeon RC-I
Length = 359
Score = 62.1 bits (144), Expect = 1e-08
Identities = 39/120 (32%), Positives = 63/120 (52%), Gaps = 5/120 (4%)
Frame = +1
Query: 220 YRVMDNNGQIIDKNE-EPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGE 396
+R++ +G NE +P L + L+ MY+ MVQ D+ + QR GR+ Y G+
Sbjct: 15 FRIVSQDGSA---NELDPGLPEDLLLKMYRLMVQARTYDEKALKLQRGGRMGTYPPIAGQ 71
Query: 397 EGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTEL----VNQCYGNCEDPGKGRQMPV 564
E I IGSA A++ +D + YRE+G + +G+ + L + YGN P R +P+
Sbjct: 72 EAIQIGSALAMAEEDWMVPSYREIGAMIAKGVPMQTLYMLWMGNDYGN-RTPDNVRCLPI 130
>UniRef50_A1UJ85 Cluster: Pyruvate dehydrogenase; n=16;
Mycobacterium|Rep: Pyruvate dehydrogenase -
Mycobacterium sp. (strain KMS)
Length = 356
Score = 60.9 bits (141), Expect = 2e-08
Identities = 29/79 (36%), Positives = 44/79 (55%)
Frame = +1
Query: 271 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVF 450
+L TL +Y+TMV +D QRQG ++ Y + G+E IG+ + L D +F
Sbjct: 27 DLPPETLAWLYETMVVTRDLDTEFVHLQRQGELALYASCRGQEAAQIGATACLRKTDWLF 86
Query: 451 SQYREVGVFLYRGMTVTEL 507
QYRE+G FL RG+ ++
Sbjct: 87 PQYREIGAFLLRGIAPAQM 105
>UniRef50_Q6L1L8 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=2; Thermoplasmatales|Rep: Pyruvate
dehydrogenase E1 component alpha subunit - Picrophilus
torridus
Length = 333
Score = 60.5 bits (140), Expect = 3e-08
Identities = 33/117 (28%), Positives = 58/117 (49%)
Frame = +1
Query: 265 EPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDL 444
E ++ K +I+ Y+ MV +DK L RQG + FY+ N G E +H A+ D
Sbjct: 3 EEDISKEDIISAYRNMVLERFLDKKLLGINRQGFLPFYIPNIGHEALHAAIGMAIRDDDF 62
Query: 445 VFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTISSPLG 615
+ YR++G + R + + ++ Q + D GR MP+H +K + + + +G
Sbjct: 63 FYPYYRDLGSDIAR-VGLDFVLAQMFSTEMDNELGRDMPLHISNKAKRVGPVITTVG 118
>UniRef50_Q8ZUR8 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=3; Pyrobaculum|Rep: Pyruvate dehydrogenase E1 alpha
subunit - Pyrobaculum aerophilum
Length = 372
Score = 59.3 bits (137), Expect = 7e-08
Identities = 37/144 (25%), Positives = 70/144 (48%), Gaps = 3/144 (2%)
Frame = +1
Query: 193 ETSYEPIPIYRVMDNNGQIIDKNEEP-NLDKATLINMYKTMVQLSHMDKILYESQRQGRI 369
+T + ++RV+ +G ++ E + L Y+ MV +D+ R G++
Sbjct: 13 KTEVKEPQVFRVLGQDGSPLETYEVGYKPSEGELAKAYRWMVLGRVLDRYALMYHRMGKV 72
Query: 370 -SFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGK 546
S Y + G E G+A AL P+D V YR + + + RG+ + + + + DP K
Sbjct: 73 KSTYGPHEGHEAADAGTALALRPEDWVAPYYRNLTLLIARGVPLEVIWAKFFAKLGDPDK 132
Query: 547 GRQMPVHYGS-KHHNMVTISSPLG 615
GR + + +G K +++I +P+G
Sbjct: 133 GRNLTIEWGGFKQWRILSIGAPIG 156
>UniRef50_A6GB57 Cluster: Pyruvate dehydrogenase; n=1; Plesiocystis
pacifica SIR-1|Rep: Pyruvate dehydrogenase -
Plesiocystis pacifica SIR-1
Length = 308
Score = 58.8 bits (136), Expect = 9e-08
Identities = 38/140 (27%), Positives = 65/140 (46%)
Frame = +1
Query: 196 TSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISF 375
T++EP + ++D+ G + D LD L + YK +V +D L + +
Sbjct: 4 TAWEPEGVEALLDSKGALADPAAVSGLD---LRSFYKQLVAARILDLKLGRLE----LPM 56
Query: 376 YMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQ 555
+ GEE + + S + +D VF R+ V L RG+ +TE++ Q G +GR
Sbjct: 57 WAPAAGEEAVSVAVGSLVGEEDWVFVGNRDAAVALTRGLPLTEILRQLLGQASAETRGRG 116
Query: 556 MPVHYGSKHHNMVTISSPLG 615
+P S+ H ++ S LG
Sbjct: 117 LPGSLSSREHKLMGASEALG 136
>UniRef50_P21873 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=33; Bacilli|Rep: Pyruvate dehydrogenase
E1 component subunit alpha - Bacillus stearothermophilus
(Geobacillus stearothermophilus)
Length = 369
Score = 58.4 bits (135), Expect = 1e-07
Identities = 26/96 (27%), Positives = 48/96 (50%)
Frame = +1
Query: 205 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 384
E P +++++ G+++++ P L L + + MV +D+ RQGR+ FY
Sbjct: 19 EQFPTFQILNEEGEVVNEEAMPELSDEQLKELMRRMVYTRILDQRSISLNRQGRLGFYAP 78
Query: 385 NYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGM 492
G+E I S AL +D + YR+V ++ G+
Sbjct: 79 TAGQEASQIASHFALEKEDFILPGYRDVPQIIWHGL 114
>UniRef50_A7D3P2 Cluster: Pyruvate dehydrogenase; n=1; Halorubrum
lacusprofundi ATCC 49239|Rep: Pyruvate dehydrogenase -
Halorubrum lacusprofundi ATCC 49239
Length = 382
Score = 57.6 bits (133), Expect = 2e-07
Identities = 38/125 (30%), Positives = 59/125 (47%), Gaps = 3/125 (2%)
Frame = +1
Query: 220 YRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 399
YRV+ +G + P+L +Y+ +V D+ QRQGRI Y G+E
Sbjct: 22 YRVLGPDGIPLPDATVPDLSDERFRAIYRDLVTTRRFDERAVSLQRQGRIGTYAPCAGQE 81
Query: 400 GIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGN---CEDPGKGRQMPVHY 570
G +GS AL+ +DL+ QYRE G + R + ++E + G+ E G P++
Sbjct: 82 GSAVGSTHALADRDLISYQYREHGAIVVRDL-LSEYLPYWLGHESGTEAIADGNVFPLNI 140
Query: 571 GSKHH 585
G H
Sbjct: 141 GIAAH 145
>UniRef50_Q9KG99 Cluster: Pyruvate dehydrogenase E1 (Lipoamide)
alpha subunit; n=1; Bacillus halodurans|Rep: Pyruvate
dehydrogenase E1 (Lipoamide) alpha subunit - Bacillus
halodurans
Length = 367
Score = 57.2 bits (132), Expect = 3e-07
Identities = 30/83 (36%), Positives = 46/83 (55%)
Frame = +1
Query: 217 IYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGE 396
+++V+ G+ + E LDK +++MYK M+ D+ + QRQGRI Y + G+
Sbjct: 18 LFQVLTPKGECQYEGSE-FLDKTFVLSMYKQMINCREFDEKALKLQRQGRIGTYASFKGQ 76
Query: 397 EGIHIGSASALSPKDLVFSQYRE 465
E IG A AL P D +F YR+
Sbjct: 77 EACQIGGALALRPTDWLFPTYRD 99
>UniRef50_A0K283 Cluster: Pyruvate dehydrogenase; n=4;
Actinobacteria (class)|Rep: Pyruvate dehydrogenase -
Arthrobacter sp. (strain FB24)
Length = 415
Score = 57.2 bits (132), Expect = 3e-07
Identities = 30/84 (35%), Positives = 43/84 (51%)
Frame = +1
Query: 274 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFS 453
LD L Y M + D+ QRQG+++ ++ G+E IGS A P+D +F
Sbjct: 58 LDAEKLRGFYADMAAIRRFDQEATALQRQGQLALWVPLTGQEAAQIGSGRASQPQDYIFP 117
Query: 454 QYREVGVFLYRGMTVTELVNQCYG 525
YRE GV L R + + EL+ Q G
Sbjct: 118 TYREHGVALTRNVDLAELLRQFRG 141
>UniRef50_A0LLM4 Cluster: Pyruvate dehydrogenase; n=1;
Syntrophobacter fumaroxidans MPOB|Rep: Pyruvate
dehydrogenase - Syntrophobacter fumaroxidans (strain DSM
10017 / MPOB)
Length = 365
Score = 56.0 bits (129), Expect = 7e-07
Identities = 31/107 (28%), Positives = 59/107 (55%)
Frame = +1
Query: 226 VMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGI 405
+++ NG++ DK+ EP++ ++ L+ +Y+ MV D+ + QRQGRI + G+E
Sbjct: 17 ILNENGEV-DKSLEPDIPESLLVKLYRAMVLSRKFDERMLILQRQGRIGTFAPIKGQEA- 74
Query: 406 HIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGK 546
+G+ + L P D + +RE+ ++RG + E V Y + G+
Sbjct: 75 QVGAVALLEPGDWLVPSFREMPAEVWRGKKL-ENVLLLYAGYNEGGR 120
>UniRef50_UPI00005103B4 Cluster: COG1071: Pyruvate/2-oxoglutarate
dehydrogenase complex, dehydrogenase (E1) component,
eukaryotic type, alpha subunit; n=1; Brevibacterium
linens BL2|Rep: COG1071: Pyruvate/2-oxoglutarate
dehydrogenase complex, dehydrogenase (E1) component,
eukaryotic type, alpha subunit - Brevibacterium linens
BL2
Length = 368
Score = 55.2 bits (127), Expect = 1e-06
Identities = 25/76 (32%), Positives = 43/76 (56%)
Frame = +1
Query: 283 ATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYR 462
A L +Y+ MV + + + RQGR++ Y + G+E +G+ +AL+P D +F YR
Sbjct: 41 AALTGLYRQMVLVRRFEAQVTHLTRQGRLATYPSAAGQEAAEVGATTALAPNDWLFPTYR 100
Query: 463 EVGVFLYRGMTVTELV 510
+ L RG+ V E++
Sbjct: 101 DSAALLTRGVPVAEIL 116
>UniRef50_Q02C52 Cluster: Pyruvate dehydrogenase; n=1; Solibacter
usitatus Ellin6076|Rep: Pyruvate dehydrogenase -
Solibacter usitatus (strain Ellin6076)
Length = 340
Score = 55.2 bits (127), Expect = 1e-06
Identities = 32/106 (30%), Positives = 54/106 (50%), Gaps = 1/106 (0%)
Frame = +1
Query: 298 MYKTMVQLSHMDKILYESQRQGRI-SFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGV 474
+Y ++ D+I + RQG+I G+E I +GSA P+D++F +R++ V
Sbjct: 30 LYYMLLMREVEDRIERKLYRQGKILGGVYVGRGQEAIPVGSALVAVPEDVMFPSHRDMAV 89
Query: 475 FLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTISSPL 612
F RG++ ++ Q G +GR +H G N+V+I S L
Sbjct: 90 FFIRGVSARRVLAQYMGRLGGLTRGRDGNMHMGDMSVNVVSIISAL 135
>UniRef50_A5UVY9 Cluster: Pyruvate dehydrogenase; n=2;
Roseiflexus|Rep: Pyruvate dehydrogenase - Roseiflexus
sp. RS-1
Length = 334
Score = 55.2 bits (127), Expect = 1e-06
Identities = 36/116 (31%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
Frame = +1
Query: 274 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALS-PKDLVF 450
L + LI +TM+ D L+ RQGR F +T G E +G A A+ D V
Sbjct: 15 LSRQRLIAGLRTMIASRETDDRLWLLNRQGRAHFVVTPAGHEATQLGCAWAIRVGHDYVV 74
Query: 451 SQYREVGVFLYRGMTVTELVNQCYGNCEDPGK-GRQMPVHYGSKHHNMVTISSPLG 615
YR++ + + G +V +++ +DP GRQM H+ S+ +V+ SS +G
Sbjct: 75 PYYRDMTLVMALGQSVLDILLHAMARRDDPSSGGRQMFGHFSSRRLRIVSGSSSVG 130
>UniRef50_Q835M4 Cluster: Pyruvate dehydrogenase complex E1
component, alpha subunit; n=10; Bacilli|Rep: Pyruvate
dehydrogenase complex E1 component, alpha subunit -
Enterococcus faecalis (Streptococcus faecalis)
Length = 371
Score = 54.8 bits (126), Expect = 2e-06
Identities = 25/97 (25%), Positives = 51/97 (52%)
Frame = +1
Query: 214 PIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYG 393
P ++++D +G+I++++ P+L L+ + MV +D+ RQGR+ F+ G
Sbjct: 24 PTFQILDQDGKIVNEDLVPDLSDEELVELMTRMVWSRVLDQRSTALNRQGRLGFFAPTAG 83
Query: 394 EEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTE 504
+E + S A+ +D + YR+V + G+ + E
Sbjct: 84 QEASQLASQFAMEKEDYLLPGYRDVPQLVQHGLPLRE 120
>UniRef50_Q7N5R1 Cluster: Similar to 3-methyl-2-oxobutanoate
dehydrogenase; n=1; Photorhabdus luminescens subsp.
laumondii|Rep: Similar to 3-methyl-2-oxobutanoate
dehydrogenase - Photorhabdus luminescens subsp.
laumondii
Length = 665
Score = 54.8 bits (126), Expect = 2e-06
Identities = 27/87 (31%), Positives = 45/87 (51%)
Frame = +1
Query: 355 RQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCE 534
RQGR F+++ G EG+ + + D++ YR+ + L RGM++ E+ + G
Sbjct: 46 RQGRAWFHVSAAGHEGLAV-LPQLMEKNDVLVPYYRDRALVLARGMSIVEMTRELMGKAT 104
Query: 535 DPGKGRQMPVHYGSKHHNMVTISSPLG 615
GR M H+ SK HN+ ++ S G
Sbjct: 105 SHSAGRTMSNHFCSKEHNIFSVVSLTG 131
>UniRef50_Q2J998 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp.
CcI3|Rep: Pyruvate dehydrogenase - Frankia sp. (strain
CcI3)
Length = 417
Score = 54.4 bits (125), Expect = 2e-06
Identities = 30/106 (28%), Positives = 51/106 (48%), Gaps = 1/106 (0%)
Frame = +1
Query: 223 RVMDNNGQII-DKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 399
R++ +G ++ D D + Y +MV +D+ QRQG + ++ G+E
Sbjct: 52 RLLAPDGSLVADSRFSVLADHELRMEFYTSMVLARRLDEEATALQRQGELVLWIPLRGQE 111
Query: 400 GIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCED 537
+GSA+A P+D +F YRE V +RG+ E++ G D
Sbjct: 112 AAQVGSAAAARPRDYLFPSYREHAVAWHRGVPAVEVIRLLRGVSHD 157
>UniRef50_A0JUQ5 Cluster: Pyruvate dehydrogenase; n=4;
Actinobacteria (class)|Rep: Pyruvate dehydrogenase -
Arthrobacter sp. (strain FB24)
Length = 392
Score = 54.4 bits (125), Expect = 2e-06
Identities = 28/78 (35%), Positives = 42/78 (53%)
Frame = +1
Query: 295 NMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGV 474
++Y+ MV + +D QRQG + + G+E IGSA +L D VFS YRE GV
Sbjct: 60 SLYEDMVVIRRIDTEATALQRQGELGLWPPLLGQEASQIGSARSLRDDDFVFSSYRENGV 119
Query: 475 FLYRGMTVTELVNQCYGN 528
RG+ + +++ GN
Sbjct: 120 AYCRGVDLADILKVWRGN 137
>UniRef50_Q749T8 Cluster: Pyruvate dehydrogenase complex E1
component, alpha subunit; n=4; Geobacter|Rep: Pyruvate
dehydrogenase complex E1 component, alpha subunit -
Geobacter sulfurreducens
Length = 352
Score = 53.6 bits (123), Expect = 4e-06
Identities = 32/89 (35%), Positives = 45/89 (50%)
Frame = +1
Query: 268 PNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLV 447
P+L L ++ M+ D+ QR+GRI Y + G+E +GSA AL P D V
Sbjct: 29 PDLSGDQLRRLHYLMLLTRTFDRRALALQREGRIGTYPSVLGQEAAQVGSAFALQPSDWV 88
Query: 448 FSQYREVGVFLYRGMTVTELVNQCYGNCE 534
F +RE+G L G V +L Q +G E
Sbjct: 89 FPSFREMGAHLTLGYPVHQLF-QYWGGDE 116
>UniRef50_Q1LFS5 Cluster: Dehydrogenase, E1 component; n=22;
Proteobacteria|Rep: Dehydrogenase, E1 component -
Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM
2839)
Length = 367
Score = 53.2 bits (122), Expect = 5e-06
Identities = 38/126 (30%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Frame = +1
Query: 253 DKNEEPNL-----DKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGS 417
D + EP+L D ATL+ +Y+ MV D QR G+I + + G+E I +G
Sbjct: 18 DGSPEPDLPDFARDPATLLPLYRAMVLTRQFDLKAIAMQRTGQIGTFASALGQEAIGVGV 77
Query: 418 ASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVT 597
A+A+ D++ YR+ RG+T+TE + +G E +P +G N V
Sbjct: 78 ATAMRRDDVLVPSYRDHAAQFVRGVTMTESL-LYWGGDERGSAFAAVPYDFG----NCVP 132
Query: 598 ISSPLG 615
I + +G
Sbjct: 133 IGTQVG 138
>UniRef50_Q8EVQ2 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=1; Mycoplasma penetrans|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Mycoplasma
penetrans
Length = 359
Score = 52.8 bits (121), Expect = 6e-06
Identities = 27/103 (26%), Positives = 51/103 (49%)
Frame = +1
Query: 220 YRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 399
Y V+D +G + L + Y TMV MD+ + + QRQG++ + N GEE
Sbjct: 13 YSVLDIDGNVTQVGYRIPLSNEEIEKAYYTMVLTRRMDEKMIKWQRQGKMLTFPPNMGEE 72
Query: 400 GIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGN 528
+ + ++ ++ +D +R VFL+ G+ + +++ GN
Sbjct: 73 ALQVATSISMDKQDWFAPAFRSAAVFLHSGVPMWKIMLVWKGN 115
>UniRef50_Q3W421 Cluster: Pyruvate dehydrogenase; n=1; Frankia sp.
EAN1pec|Rep: Pyruvate dehydrogenase - Frankia sp.
EAN1pec
Length = 358
Score = 52.8 bits (121), Expect = 6e-06
Identities = 29/102 (28%), Positives = 49/102 (48%), Gaps = 1/102 (0%)
Frame = +1
Query: 223 RVMDNNGQIIDKNE-EPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 399
R++ +G ++D D + Y+ MV+ +D+ QRQG + ++ G+E
Sbjct: 19 RLLAPDGTLVDDPRFTVRADSRQTESFYREMVRARRLDEEATALQRQGELVLWIPLRGQE 78
Query: 400 GIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYG 525
+GSA+A P D +F YRE V +RG+ E + G
Sbjct: 79 AAQVGSAAAAEPADFLFPSYREHAVVWHRGIPPVEALRLLRG 120
>UniRef50_Q12FH4 Cluster: Pyruvate dehydrogenase; n=37;
Bacteria|Rep: Pyruvate dehydrogenase - Polaromonas sp.
(strain JS666 / ATCC BAA-500)
Length = 337
Score = 52.4 bits (120), Expect = 8e-06
Identities = 29/98 (29%), Positives = 53/98 (54%), Gaps = 1/98 (1%)
Frame = +1
Query: 277 DKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPKDLVFS 453
DKA + + M+++ M++ + + +I ++ Y GEE + +G+ AL P+D V +
Sbjct: 17 DKAFALAVLAGMLRIRRMEEKCAQLYGEQKIRGFLHLYIGEEAVAVGALRALQPQDNVVA 76
Query: 454 QYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVH 567
YRE G L RG+ + ++ + YG E +GR +H
Sbjct: 77 TYREHGHALLRGLAMNGIMAEMYGKREGCSRGRGGSMH 114
>UniRef50_Q1AZ54 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacter
xylanophilus DSM 9941|Rep: Pyruvate dehydrogenase -
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 325
Score = 52.0 bits (119), Expect = 1e-05
Identities = 29/101 (28%), Positives = 53/101 (52%), Gaps = 1/101 (0%)
Frame = +1
Query: 250 IDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRIS-FYMTNYGEEGIHIGSASA 426
+++ E P ++ L++ Y+ MV+ ++ L +G+IS FY G+EG +G+ +A
Sbjct: 1 MEEREMPERER--LLDFYERMVRCMLWEQKLLRFIDEGKISGFYHAGRGQEGTQVGAVAA 58
Query: 427 LSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKG 549
L P D + +R G + RGM +++L N E +G
Sbjct: 59 LGPDDYMMYAHRGCGYMVARGMPMSKLFGDFLANTEGSTRG 99
>UniRef50_A7K3C9 Cluster: Dehydrogenase E1 component superfamily;
n=10; Gammaproteobacteria|Rep: Dehydrogenase E1
component superfamily - Vibrio sp. Ex25
Length = 398
Score = 51.6 bits (118), Expect = 1e-05
Identities = 29/101 (28%), Positives = 50/101 (49%), Gaps = 1/101 (0%)
Frame = +1
Query: 193 ETSYEPIPIYRVMDNNGQIIDKNEEPN-LDKATLINMYKTMVQLSHMDKILYESQRQGRI 369
E + + +P++R +D++G ++ + PN D TL+ Y+ MV D QR G++
Sbjct: 34 EMNVQALPMHRFIDHHGDLV--GQLPNWADTETLVGFYRDMVLTRTYDNKAVALQRTGKL 91
Query: 370 SFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGM 492
Y ++ G E I I AL D+ YR++ RG+
Sbjct: 92 GTYPSHLGAEAIGIAVGRALKADDVFVPYYRDMPAMWCRGI 132
>UniRef50_A3RZM3 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=5; Proteobacteria|Rep: Pyruvate dehydrogenase
E1 component alpha subunit - Ralstonia solanacearum
UW551
Length = 368
Score = 51.6 bits (118), Expect = 1e-05
Identities = 24/73 (32%), Positives = 42/73 (57%)
Frame = +1
Query: 286 TLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYRE 465
TL+ +Y+ MV D QR G++ + ++ G+E I +G ASA+ +D++F YR+
Sbjct: 34 TLLALYRAMVLTRAFDTKAIALQRTGKLGTFASSVGQEAIGVGVASAMRAEDVLFPSYRD 93
Query: 466 VGVFLYRGMTVTE 504
L RG+++ E
Sbjct: 94 HSAQLLRGVSMAE 106
>UniRef50_Q5SJR9 Cluster: Pyruvate dehydrogenase (Lipoamide) (EC
1.2.4.1) E1-alpha chain; n=2; Thermus thermophilus|Rep:
Pyruvate dehydrogenase (Lipoamide) (EC 1.2.4.1) E1-alpha
chain - Thermus thermophilus (strain HB8 / ATCC 27634 /
DSM 579)
Length = 346
Score = 51.2 bits (117), Expect = 2e-05
Identities = 27/87 (31%), Positives = 44/87 (50%)
Frame = +1
Query: 250 IDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASAL 429
+D+ E P ++ L +Y+ M + D+ QRQGR+ Y G+E +G A AL
Sbjct: 9 LDEGEFPLAEEEAL-RLYRAMRRARFFDEKALTLQRQGRLGVYAPFMGQEAAQVGVALAL 67
Query: 430 SPKDLVFSQYREVGVFLYRGMTVTELV 510
+D V YRE + L +G+ + L+
Sbjct: 68 EERDWVVPSYRESAMLLAKGLPIHTLI 94
>UniRef50_A0JY23 Cluster: Pyruvate dehydrogenase; n=2;
Arthrobacter|Rep: Pyruvate dehydrogenase - Arthrobacter
sp. (strain FB24)
Length = 359
Score = 50.8 bits (116), Expect = 3e-05
Identities = 32/102 (31%), Positives = 48/102 (47%), Gaps = 5/102 (4%)
Frame = +1
Query: 274 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASAL-SPKDLVF 450
L L +Y MV + H+D QRQG I Y G+E +GS A+ + +D VF
Sbjct: 30 LTAGQLRELYSLMVAVRHLDTSAIAWQRQGLIPGYAPELGQEAAQVGSGYAVDTARDFVF 89
Query: 451 SQYREVGVFLYRGMTVTELVN----QCYGNCEDPGKGRQMPV 564
YRE+GV G+ + ++ +G DP + R P+
Sbjct: 90 PTYREMGVARAMGVDMVAYMSTHKATWHGGLYDPLESRLAPI 131
>UniRef50_Q4MTG0 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=38; Bacilli|Rep: Pyruvate dehydrogenase
E1 component subunit alpha - Bacillus cereus
Length = 371
Score = 50.8 bits (116), Expect = 3e-05
Identities = 23/90 (25%), Positives = 45/90 (50%)
Frame = +1
Query: 223 RVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEG 402
++++ G+++++ P L L + + MV +D+ RQGR+ FY G+E
Sbjct: 27 QILNEKGEVVNEAAMPELSDDQLKELMRRMVYTRVLDQRSISLNRQGRLGFYAPTAGQEA 86
Query: 403 IHIGSASALSPKDLVFSQYREVGVFLYRGM 492
+ S AL +D + YR+V ++ G+
Sbjct: 87 SQLASHFALEAEDFILPGYRDVPQLVWHGL 116
>UniRef50_A6WG12 Cluster: Pyruvate dehydrogenase; n=3;
Actinomycetales|Rep: Pyruvate dehydrogenase -
Kineococcus radiotolerans SRS30216
Length = 390
Score = 50.4 bits (115), Expect = 3e-05
Identities = 26/83 (31%), Positives = 46/83 (55%)
Frame = +1
Query: 265 EPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDL 444
E +L+ L+ + + MV L +D QRQG++ + + G+E +GSA+A +D
Sbjct: 39 EVDLEPEELLALLRDMVLLRRLDAEGEALQRQGQLGLWPGSRGQEAAQVGSATACRRQDQ 98
Query: 445 VFSQYREVGVFLYRGMTVTELVN 513
VF YR+ G L RG+ ++++
Sbjct: 99 VFPSYRDHGAVLGRGIDPVDILS 121
>UniRef50_A7CXZ4 Cluster: Pyruvate dehydrogenase; n=1; Opitutaceae
bacterium TAV2|Rep: Pyruvate dehydrogenase - Opitutaceae
bacterium TAV2
Length = 365
Score = 50.0 bits (114), Expect = 4e-05
Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 1/101 (0%)
Frame = +1
Query: 271 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPKDLV 447
+L A I +Y+TMV++ ++ + + +I ++ Y G+E + +G S + D V
Sbjct: 30 DLTPAARIELYRTMVRIRRFEERSLRAYQAKKIGGFLHLYIGQEAVAVGCCSLMGEHDHV 89
Query: 448 FSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHY 570
+ YR+ G + GM L+ + YG KG+ +HY
Sbjct: 90 ITAYRDHGHAIAVGMDTKALMAELYGKATGCSKGKGGSMHY 130
>UniRef50_Q83DQ6 Cluster: Dehydrogenase, E1 component, alpha
subunit; n=3; Coxiella burnetii|Rep: Dehydrogenase, E1
component, alpha subunit - Coxiella burnetii
Length = 368
Score = 49.6 bits (113), Expect = 6e-05
Identities = 25/95 (26%), Positives = 46/95 (48%), Gaps = 6/95 (6%)
Frame = +1
Query: 244 QIIDKNEEPN------LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGI 405
Q +D N P D L+ +Y+ M + +D QR G++ Y ++ G+E +
Sbjct: 17 QFLDANSNPTQPFPDFADPDMLLYLYRRMALIRQLDNKAINLQRTGKMGTYPSSRGQEAV 76
Query: 406 HIGSASALSPKDLVFSQYREVGVFLYRGMTVTELV 510
IG SA+ +D+ YR+ G G+ ++E++
Sbjct: 77 GIGMGSAMQKEDIFCPYYRDQGALFEHGIKLSEIL 111
>UniRef50_Q479Q2 Cluster: Dehydrogenase, E1 component; n=2;
Rhodocyclaceae|Rep: Dehydrogenase, E1 component -
Dechloromonas aromatica (strain RCB)
Length = 320
Score = 49.2 bits (112), Expect = 8e-05
Identities = 25/108 (23%), Positives = 51/108 (47%)
Frame = +1
Query: 292 INMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVG 471
+ +Y+ ++ + + + GRI T+ G+E +G+ +AL DL+ + +R G
Sbjct: 11 LRLYEQLLLIRAYENAIVRGSTDGRIPGTCTSVGQEAAAVGAINALEADDLILTNHRSAG 70
Query: 472 VFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTISSPLG 615
L RG ++ + G + KGR +H +K +V ++ +G
Sbjct: 71 HLLARGADPGRMLAEVMGRRDGYCKGRSGSLHISAKELGVVLTTTIVG 118
>UniRef50_Q53610 Cluster: Branched-chain alpha-keto acid
dehydrogenase E1-alpha subunit; n=16;
Actinomycetales|Rep: Branched-chain alpha-keto acid
dehydrogenase E1-alpha subunit - Streptomyces
avermitilis
Length = 406
Score = 48.8 bits (111), Expect = 1e-04
Identities = 28/79 (35%), Positives = 36/79 (45%)
Frame = +1
Query: 289 LINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREV 468
L +Y+ MV D QRQG + + + G+E IGS A D VF YRE
Sbjct: 70 LRGLYRDMVLSRRFDAEATSLQRQGELGLWASMLGQEAAQIGSGRATRDDDYVFPTYREH 129
Query: 469 GVFLYRGMTVTELVNQCYG 525
GV RG+ T L+ G
Sbjct: 130 GVAWCRGVDPTNLLGMFRG 148
>UniRef50_Q67SE7 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=2; Bacilli|Rep: Pyruvate dehydrogenase E1 alpha
subunit - Symbiobacterium thermophilum
Length = 368
Score = 48.4 bits (110), Expect = 1e-04
Identities = 29/106 (27%), Positives = 52/106 (49%), Gaps = 1/106 (0%)
Frame = +1
Query: 214 PIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYG 393
P+ R++ +G +++ L L ++Y+ MV L D+ QRQGR+ + G
Sbjct: 15 PVRRILQADGTLLEP-VPAFLSVDQLKDVYRKMVYLRVFDQRCLNLQRQGRMGTFAPFSG 73
Query: 394 EEGIHIGSASALSP-KDLVFSQYREVGVFLYRGMTVTELVNQCYGN 528
+E +GSA L P +D +F YR+ G G+ + ++ G+
Sbjct: 74 QEASQVGSAYLLRPDRDWIFPTYRDHGAMHVMGVPLVNILRYFMGD 119
>UniRef50_Q49108 Cluster: Pyruvate dehydrogenase EI alpha subunit;
n=5; Mollicutes|Rep: Pyruvate dehydrogenase EI alpha
subunit - Mycoplasma capricolum
Length = 370
Score = 48.4 bits (110), Expect = 1e-04
Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 1/108 (0%)
Frame = +1
Query: 226 VMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGI 405
V+D +G++I+ P + ++ YK M D QRQGR+ ++++ G+E
Sbjct: 17 VLDKDGKVINPKLMPKISDQEILEAYKIMNLSRRQDIYQNTMQRQGRLLSFLSSTGQEAC 76
Query: 406 HIGSASALSPK-DLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGK 546
+ +AL+ K D S YR +L G V ++ GN E GK
Sbjct: 77 EVAYINALNKKTDHFVSGYRNNAAWLAMGQLVRNIMLYWIGN-EAGGK 123
>UniRef50_A4F1Y5 Cluster: Branched-chain alpha-keto acid
decarboxylase; n=1; Streptomyces virginiae|Rep:
Branched-chain alpha-keto acid decarboxylase -
Streptomyces virginiae
Length = 677
Score = 48.0 bits (109), Expect = 2e-04
Identities = 25/87 (28%), Positives = 41/87 (47%)
Frame = +1
Query: 355 RQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCE 534
RQG+ F++++ G E + L P+DL+F YR+ + L RGM
Sbjct: 57 RQGQAWFHISSAGHEAL-AALCELLEPEDLIFPHYRDRTLMLARGMDAEGQARDLMAKGG 115
Query: 535 DPGKGRQMPVHYGSKHHNMVTISSPLG 615
GR M H+ + N+ +++SP G
Sbjct: 116 SHSAGRNMSSHFSHRPGNVFSLASPTG 142
>UniRef50_A5IXN2 Cluster: Pyruvate dehydrogenase E1 component,
alphasubunit; n=1; Mycoplasma agalactiae|Rep: Pyruvate
dehydrogenase E1 component, alphasubunit - Mycoplasma
agalactiae
Length = 363
Score = 46.8 bits (106), Expect = 4e-04
Identities = 27/108 (25%), Positives = 50/108 (46%)
Frame = +1
Query: 205 EPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT 384
+P R +D +G++I + + K L+ MYK M++ D Q+ GR+ +
Sbjct: 14 DPNETVRFLDVDGKLIQEFKPSAETKKKLVEMYKNMIRSRQWDLYSLTLQKTGRLGTFAP 73
Query: 385 NYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGN 528
GEE G L+ +D YR + L RG+++ ++ + G+
Sbjct: 74 ALGEEAALTGIGFNLNKEDWFIPHYRVLPTQLARGISMDKIYSYWQGS 121
>UniRef50_Q1XDM0 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=52; cellular organisms|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Porphyra
yezoensis
Length = 346
Score = 46.4 bits (105), Expect = 5e-04
Identities = 28/109 (25%), Positives = 55/109 (50%), Gaps = 1/109 (0%)
Frame = +1
Query: 271 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPKDLV 447
NL+K+ L+ +Y+ M+ + + + + +G++ ++ Y G+E + G L+P D V
Sbjct: 20 NLNKSNLLVLYEDMLLGRNFEDMCAQMYYKGKMFGFVHLYNGQEAVSTGVIKLLNPTDYV 79
Query: 448 FSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMV 594
S YR+ L +G+ ++ + +G KGR +H S HN +
Sbjct: 80 CSTYRDHVHALSKGVPSKNVMAELFGKETGCSKGRGGSMHIFSAPHNFL 128
>UniRef50_A0LFE6 Cluster: Pyruvate dehydrogenase; n=1;
Syntrophobacter fumaroxidans MPOB|Rep: Pyruvate
dehydrogenase - Syntrophobacter fumaroxidans (strain DSM
10017 / MPOB)
Length = 320
Score = 46.0 bits (104), Expect = 7e-04
Identities = 29/114 (25%), Positives = 54/114 (47%), Gaps = 2/114 (1%)
Frame = +1
Query: 280 KATLINMYKTMVQLSHMDKILYE-SQRQGRISFYMTNY-GEEGIHIGSASALSPKDLVFS 453
K L+ M ++M+ ++ L E Q +G++ M G+E + G +AL P+D++
Sbjct: 5 KEKLLEMLRSMLLTRRFEEKLTELCQIEGKVPGMMILCTGQEAVAAGVCAALEPQDVIVP 64
Query: 454 QYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTISSPLG 615
+R G L RG L+ +C+G KG+ +H N + ++ +G
Sbjct: 65 NHRSHGHLLARGADPNALMAECFGKRTGFNKGKSGTLHVAVPEVNALCTTTVVG 118
>UniRef50_Q1IY28 Cluster: Pyruvate dehydrogenase; n=1; Deinococcus
geothermalis DSM 11300|Rep: Pyruvate dehydrogenase -
Deinococcus geothermalis (strain DSM 11300)
Length = 361
Score = 45.6 bits (103), Expect = 0.001
Identities = 22/78 (28%), Positives = 40/78 (51%)
Frame = +1
Query: 277 DKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQ 456
D T + +Y+ M + H D+ + R GR+ + G E +G+A+AL+ D +F
Sbjct: 36 DVPTRLKLYRLMRRARHFDERAWVLYRTGRMGVFPPYGGMEASQVGTAAALTHADWLFPT 95
Query: 457 YREVGVFLYRGMTVTELV 510
YR+ G L G+ + + +
Sbjct: 96 YRDTGAALTYGLPLEQTI 113
>UniRef50_Q5VGY4 Cluster: Pyruvate dehydrogenase alpha subunit; n=6;
Plasmodium|Rep: Pyruvate dehydrogenase alpha subunit -
Plasmodium falciparum
Length = 608
Score = 45.6 bits (103), Expect = 0.001
Identities = 33/134 (24%), Positives = 63/134 (47%), Gaps = 2/134 (1%)
Frame = +1
Query: 199 SYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFY 378
+Y IY M+NN I + + N+ + + +Y+ M + ++ + R++ +
Sbjct: 166 NYSEFNIY--MENNN-IEEYISDVNISREEICTLYEDMYLGRLFENLVAKLYYNKRVNGF 222
Query: 379 MTNY-GEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGN-CEDPGKGR 552
+ Y G+E + G L D V S YR+ L +G+ +++N+ YGN KG+
Sbjct: 223 VHLYNGQEAVSTGIIKNLKNSDFVTSTYRDHVHALSKGVPAHKILNELYGNYYGSTNKGK 282
Query: 553 QMPVHYGSKHHNMV 594
+H SK +N +
Sbjct: 283 GGSMHIYSKENNFI 296
>UniRef50_Q8D6Q7 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex, dehydrogenase component, eukaryotic type, alpha
subunit; n=4; Vibrionaceae|Rep: Pyruvate/2-oxoglutarate
dehydrogenase complex, dehydrogenase component,
eukaryotic type, alpha subunit - Vibrio vulnificus
Length = 364
Score = 45.2 bits (102), Expect = 0.001
Identities = 24/97 (24%), Positives = 46/97 (47%), Gaps = 1/97 (1%)
Frame = +1
Query: 205 EPIPIYRVMDNNGQIIDKNEEPN-LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYM 381
+ +P++R +D G + ++ P+ + L+ Y+ M+ D QR G++ Y
Sbjct: 4 QALPMHRFLDYEGNV--QSPLPSWASEERLVQFYRDMLITRAYDNKAVALQRTGKLGTYP 61
Query: 382 TNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGM 492
++ G E +G AL P D+ YR++ RG+
Sbjct: 62 SHLGSEAFGVGIGHALKPSDVFIPYYRDMPAMWVRGI 98
>UniRef50_Q83FF2 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=2; Tropheryma whipplei|Rep: Pyruvate
dehydrogenase E1 component alpha subunit - Tropheryma
whipplei (strain Twist) (Whipple's bacillus)
Length = 370
Score = 45.2 bits (102), Expect = 0.001
Identities = 25/98 (25%), Positives = 45/98 (45%)
Frame = +1
Query: 271 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVF 450
+LD + Y+ ++ + +D QR+G ++ + YG+E IG+ A S D++F
Sbjct: 33 SLDVEDIQRFYRDIILVRQIDHEAALLQRRGELALWPPVYGQEASQIGATYACSENDMIF 92
Query: 451 SQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPV 564
YR+ V RG+ + + G + RQ V
Sbjct: 93 PSYRDHAVMHARGIDLVHIAKLFRGASNNDWDVRQHKV 130
>UniRef50_Q74AD3 Cluster: Dehydrogenase complex, E1 component, alpha
subunit; n=5; Geobacter|Rep: Dehydrogenase complex, E1
component, alpha subunit - Geobacter sulfurreducens
Length = 325
Score = 45.2 bits (102), Expect = 0.001
Identities = 25/99 (25%), Positives = 48/99 (48%), Gaps = 1/99 (1%)
Frame = +1
Query: 274 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPKDLVF 450
L + L+ M++ MV ++ E +G I+ ++ Y G+E + +G+ +AL D +
Sbjct: 9 LPDSELLKMHEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAALRKDDYIL 68
Query: 451 SQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVH 567
S YRE + RG ++ + +G KG+ +H
Sbjct: 69 SAYREHAQAIVRGAEPRRVMAELFGKATGMCKGKGGSMH 107
>UniRef50_Q3DYK5 Cluster: Dehydrogenase, E1 component; n=3;
Bacteria|Rep: Dehydrogenase, E1 component - Chloroflexus
aurantiacus J-10-fl
Length = 321
Score = 45.2 bits (102), Expect = 0.001
Identities = 18/64 (28%), Positives = 35/64 (54%)
Frame = +1
Query: 376 YMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQ 555
Y + G E + + +A +L P+D++ +R++G +L RG+T ++ Q G +GR
Sbjct: 39 YFSQIGHEALSVAAALSLGPRDIIAPMHRDLGAYLVRGLTPKRILAQWLGRETGVTRGRD 98
Query: 556 MPVH 567
+H
Sbjct: 99 ANLH 102
>UniRef50_A6DTS3 Cluster: Dehydrogenase complex, E1 component, alpha
subunit; n=1; Lentisphaera araneosa HTCC2155|Rep:
Dehydrogenase complex, E1 component, alpha subunit -
Lentisphaera araneosa HTCC2155
Length = 320
Score = 45.2 bits (102), Expect = 0.001
Identities = 26/107 (24%), Positives = 54/107 (50%), Gaps = 1/107 (0%)
Frame = +1
Query: 271 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPKDLV 447
N+ K + M + M+++ ++ +S +Q I+ + Y G+E + +G+ + L+P D
Sbjct: 3 NIGKEKALQMLEQMIRVRRFEEGCLKSYQQKFITGFCHTYIGQEAVAVGAMAHLTPTDAY 62
Query: 448 FSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHN 588
+ YR L G+T E++ + +G +G+ +H SK +N
Sbjct: 63 VTSYRCHAQGLIGGLTSREVMAEMFGKITGCVRGKGGSMHVFSKKNN 109
>UniRef50_Q1KSF1 Cluster: Apicoplast pyruvate dehydrogenase E1 alpha
subunit; n=1; Toxoplasma gondii|Rep: Apicoplast pyruvate
dehydrogenase E1 alpha subunit - Toxoplasma gondii
Length = 635
Score = 45.2 bits (102), Expect = 0.001
Identities = 25/87 (28%), Positives = 41/87 (47%)
Frame = +1
Query: 334 KILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVN 513
++ Y + G + Y G+E + G L P D V S YR+ +G+ V E++
Sbjct: 277 RLYYMGKTAGFVHLYT---GQEAVSAGVIKLLRPDDAVVSTYRDHVHATSKGVPVREVMA 333
Query: 514 QCYGNCEDPGKGRQMPVHYGSKHHNMV 594
+ +G +GR +H SK HNM+
Sbjct: 334 ELFGKATGCSRGRGGSMHMFSKKHNMI 360
>UniRef50_Q7NLM8 Cluster: Gll1094 protein; n=1; Gloeobacter
violaceus|Rep: Gll1094 protein - Gloeobacter violaceus
Length = 481
Score = 44.8 bits (101), Expect = 0.002
Identities = 25/85 (29%), Positives = 42/85 (49%)
Frame = +1
Query: 355 RQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCE 534
RQG+ ++ G E + I L +D +F+ YR+ + L +G T +L + +
Sbjct: 34 RQGKGWIHIPGMGHESL-IAITHHLHREDYLFTYYRDRALMLGKGFTAQQLAWDYFACAK 92
Query: 535 DPGKGRQMPVHYGSKHHNMVTISSP 609
GR MPVH +KH N+ ++P
Sbjct: 93 SSTGGRGMPVHCSAKHLNIFPPATP 117
>UniRef50_A4VXG8 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex, dehydrogenase (E1) component, eukaryotic type,
alpha subunit; n=40; Streptococcus|Rep:
Pyruvate/2-oxoglutarate dehydrogenase complex,
dehydrogenase (E1) component, eukaryotic type, alpha
subunit - Streptococcus suis (strain 05ZYH33)
Length = 337
Score = 44.8 bits (101), Expect = 0.002
Identities = 26/101 (25%), Positives = 53/101 (52%), Gaps = 2/101 (1%)
Frame = +1
Query: 271 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY--GEEGIHIGSASALSPKDL 444
++ K ++M+ M Q+ +D L + R+G + MT++ GEE +G + L+ +D+
Sbjct: 18 SITKEQHLDMFLKMQQIRDVDMKLNKLVRRGFVQG-MTHFSVGEEAAAVGPIAGLTDEDI 76
Query: 445 VFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVH 567
+FS +R G + +G+ + ++ + G KGR +H
Sbjct: 77 IFSHHRGHGHVIAKGIDINGMMAELAGKATGTSKGRGGSMH 117
>UniRef50_A0LTQ9 Cluster: Pyruvate dehydrogenase; n=1; Acidothermus
cellulolyticus 11B|Rep: Pyruvate dehydrogenase -
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Length = 342
Score = 44.8 bits (101), Expect = 0.002
Identities = 26/102 (25%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Frame = +1
Query: 292 INMYKTMVQLSHMDKILYESQRQGRISFYM-TNYGEEGIHIGSASALSPKDLVFSQYREV 468
+++++ MV+L ++ ++ QG + + G+E + G A+A+ P DL F+ YR
Sbjct: 24 LDLFELMVRLRFFERRAHDLFLQGLVKGTSHLSLGQEAVATGFAAAMEPTDLTFATYRGH 83
Query: 469 GVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMV 594
L RG ++T ++ + G G+ +H S H M+
Sbjct: 84 AHTLSRGASMTGVMGELMGRSVGLMAGKGGSMHLTSVEHGMM 125
>UniRef50_A0LSF3 Cluster: Pyruvate dehydrogenase; n=5; Bacteria|Rep:
Pyruvate dehydrogenase - Acidothermus cellulolyticus
(strain ATCC 43068 / 11B)
Length = 375
Score = 44.0 bits (99), Expect = 0.003
Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 1/84 (1%)
Frame = +1
Query: 301 YKTMVQLSHMDKILYESQRQGRISFYM-TNYGEEGIHIGSASALSPKDLVFSQYREVGVF 477
Y+ M + ++ E ++ +I Y N GEE +G A++P D +F+ YRE G
Sbjct: 45 YRMMQLIRRFEERAAEMYQRAKIGGYCHLNLGEEATVVGLMDAMAPHDYLFTTYREHGYA 104
Query: 478 LYRGMTVTELVNQCYGNCEDPGKG 549
L RG+ ++ + +G KG
Sbjct: 105 LARGIDPGRVMAELFGRTTGVSKG 128
>UniRef50_P16387 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha, mitochondrial precursor; n=34;
Dikarya|Rep: Pyruvate dehydrogenase E1 component subunit
alpha, mitochondrial precursor - Saccharomyces
cerevisiae (Baker's yeast)
Length = 420
Score = 44.0 bits (99), Expect = 0.003
Identities = 36/119 (30%), Positives = 55/119 (46%), Gaps = 7/119 (5%)
Frame = +1
Query: 280 KATLINMYKTMVQLSHMDKILYESQRQGRI-SFYMTNYGEEGIHIGSASALSPKDLVFSQ 456
KATL+ MYK MV + M+ + +I F + G+E I +G +A++ D + +
Sbjct: 78 KATLLQMYKDMVIIRRMEMACDALYKAKKIRGFCHLSVGQEAIAVGIENAITKLDSIITS 137
Query: 457 YREVGVFLYRGMTVTELVNQCYGNCE--DPGKGRQM----PVHYGSKHHNMVTISSPLG 615
YR G RG +V ++ + G GKG M P YG + +V PLG
Sbjct: 138 YRCHGFTFMRGASVKAVLAELMGRRAGVSYGKGGSMHLYAPGFYGG--NGIVGAQVPLG 194
>UniRef50_Q1EGI2 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=6; Spirotrichea|Rep: Pyruvate dehydrogenase E1 alpha
subunit - Euplotes sp. BB-2004
Length = 389
Score = 43.6 bits (98), Expect = 0.004
Identities = 34/139 (24%), Positives = 64/139 (46%), Gaps = 4/139 (2%)
Frame = +1
Query: 184 FFNETSYEPIPIYRVMDNNGQIIDKNEEPN---LDKATLINMYKTMVQLSHMDKILYESQ 354
FF+ T +P ++V I+++E P K+ L+N YK M + ++ +
Sbjct: 22 FFSSTIEVELPKFKV-----HRIEESELPTKATTTKSELLNYYKDMALMRRVEIVSDMLY 76
Query: 355 RQGRISFYMTNY-GEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNC 531
+ I + Y G+E I +G +AL+ +D + + YR+ + RG T E++ +
Sbjct: 77 KNKWIRGFCHLYDGQESITVGMEAALTMEDHIINAYRDHTTAMGRGHTSYEIIAEMMQRS 136
Query: 532 EDPGKGRQMPVHYGSKHHN 588
KG+ +HY +N
Sbjct: 137 TGSSKGKGGSMHYYCSKNN 155
>UniRef50_Q9HNV6 Cluster: Pyruvate dehydrogenase alpha subunit; n=1;
Halobacterium salinarum|Rep: Pyruvate dehydrogenase
alpha subunit - Halobacterium salinarium (Halobacterium
halobium)
Length = 322
Score = 43.6 bits (98), Expect = 0.004
Identities = 23/67 (34%), Positives = 37/67 (55%)
Frame = +1
Query: 310 MVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRG 489
MV+ H D+ QR+G + Y G+EG +G+A AL+ D +F YR + L RG
Sbjct: 1 MVRARHFDERALALQRRGWMPGYPPFKGQEGSQVGAAHALAGDDWLFPTYRSNAMQLARG 60
Query: 490 MTVTELV 510
+ ++L+
Sbjct: 61 VPASDLL 67
>UniRef50_Q6MAE2 Cluster: Putative pyruvate dehydrogenase
(Lipoamide), E1 component, alpha chain; n=1; Candidatus
Protochlamydia amoebophila UWE25|Rep: Putative pyruvate
dehydrogenase (Lipoamide), E1 component, alpha chain -
Protochlamydia amoebophila (strain UWE25)
Length = 342
Score = 43.2 bits (97), Expect = 0.005
Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 1/100 (1%)
Frame = +1
Query: 274 LDKATLINMYKTMVQLSHMDKILYESQRQGRIS-FYMTNYGEEGIHIGSASALSPKDLVF 450
L LI ++ M+++ + + + +QG+I F+ G+E I + A+ +
Sbjct: 21 LGPQALIECFQQMLKIRNFELRAESAYQQGKIGGFFHAYVGQEAIQTAAVQAIGQSNWYA 80
Query: 451 SQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHY 570
+ YR + L G T EL+ + YG KGR +H+
Sbjct: 81 TSYRCHALALLLGATPNELMAELYGRATGNAKGRGGSMHF 120
>UniRef50_A2QWB4 Cluster: Catalytic activity: Pyruvate + Lipoamide
<=> S-Acetyldihydrolipoamide + CO2; n=3; Ascomycota|Rep:
Catalytic activity: Pyruvate + Lipoamide <=>
S-Acetyldihydrolipoamide + CO2 - Aspergillus niger
Length = 403
Score = 42.7 bits (96), Expect = 0.007
Identities = 30/117 (25%), Positives = 56/117 (47%), Gaps = 5/117 (4%)
Frame = +1
Query: 280 KATLINMYKTMVQLSHMDKILYESQRQGRI-SFYMTNYGEEGIHIGSASALSPKDLVFSQ 456
K+ L +Y M + M+ + ++ +I F + G+E + +G +SP+D V +
Sbjct: 70 KSQLKQLYYDMSLIRRMELAADKLYKEQKIRGFCHLSTGQEAVAVGVEHGISPEDKVITA 129
Query: 457 YREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKH----HNMVTISSPLG 615
YR G L RG +V ++ + G + G+ VH +K+ + +V + PLG
Sbjct: 130 YRAHGFTLMRGGSVKSIIGELLGRRDGICHGKGGSVHMFTKNFFGGNGIVGSNVPLG 186
>UniRef50_Q8AB00 Cluster: 2-oxoisovalerate dehydrogenase beta
subunit; n=11; cellular organisms|Rep: 2-oxoisovalerate
dehydrogenase beta subunit - Bacteroides
thetaiotaomicron
Length = 678
Score = 42.3 bits (95), Expect = 0.009
Identities = 33/116 (28%), Positives = 47/116 (40%), Gaps = 3/116 (2%)
Frame = +1
Query: 277 DKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALS-PKDLVF 450
D TL Y M +D+ Q Q Y Y G +GI + + +D +F
Sbjct: 11 DVETLKKWYHLMTLGRALDEKAPSYQLQSLGWSYHAPYAGHDGIQLAVGQVFTLGEDFLF 70
Query: 451 SQYREVGVFLYRGMTVTELVNQCYGNCEDPGK-GRQMPVHYGSKHHNMVTISSPLG 615
YR++ L GMT E++ DPG GR M H+ ++ ISS G
Sbjct: 71 PYYRDMLTVLSAGMTAEEIILNGISKATDPGSGGRHMSNHFAKPEWHIENISSATG 126
>UniRef50_Q1ARM0 Cluster: Pyruvate dehydrogenase; n=3; Bacteria|Rep:
Pyruvate dehydrogenase - Rubrobacter xylanophilus
(strain DSM 9941 / NBRC 16129)
Length = 332
Score = 42.3 bits (95), Expect = 0.009
Identities = 29/100 (29%), Positives = 53/100 (53%), Gaps = 5/100 (5%)
Frame = +1
Query: 274 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPKDLVF 450
L + L+ M + M+++ ++ L E ++G++ ++ Y GEE + +G+ SAL D +
Sbjct: 2 LGEEKLVGMLRLMLRIRRFEEKLAELFKRGKLPGFVHLYIGEEAVAVGACSALREDDRIT 61
Query: 451 SQYREVGVFLYRGMTVT----ELVNQCYGNCEDPGKGRQM 558
S +R G + +G V+ EL+ + G C GKG M
Sbjct: 62 STHRGHGHVIAKGADVSRMMAELLGKEAGYCR--GKGGSM 99
>UniRef50_Q8SQM8 Cluster: PYRUVATE DEHYDROGENASE E1 COMPONENT ALPHA
SUBUNIT; n=1; Encephalitozoon cuniculi|Rep: PYRUVATE
DEHYDROGENASE E1 COMPONENT ALPHA SUBUNIT -
Encephalitozoon cuniculi
Length = 349
Score = 42.3 bits (95), Expect = 0.009
Identities = 34/119 (28%), Positives = 57/119 (47%), Gaps = 5/119 (4%)
Frame = +1
Query: 274 LDKATLINMYKTMVQLSHMDKIL-YESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVF 450
+DKA I YK M+++ MD+ + E +R+ F + G+EGI+ A+ D+
Sbjct: 36 VDKAVYI--YKQMMRMRCMDEAMDREYKRKNIRGFCHLSIGQEGIYAALEYAMDG-DVAV 92
Query: 451 SQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKH----HNMVTISSPLG 615
S YR G+ G ++ E++ + G KG+ +H +K H +V PLG
Sbjct: 93 SSYRCHGIAYVTGCSILEIMGEVLGRQAGVCKGKGGSMHLYNKSFFGGHGIVGAQIPLG 151
>UniRef50_Q8PQ82 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=7; Xanthomonadaceae|Rep: Pyruvate dehydrogenase E1
alpha subunit - Xanthomonas axonopodis pv. citri
Length = 362
Score = 41.5 bits (93), Expect = 0.015
Identities = 25/95 (26%), Positives = 42/95 (44%), Gaps = 1/95 (1%)
Frame = +1
Query: 211 IPIYRVMDNNGQII-DKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTN 387
I + MD +GQ + D + L+ ++K M+ + D QR G++ Y
Sbjct: 9 IDYLQYMDADGQWVRDDLPADAANPQHLLALFKRMLFVRTFDTKSVALQRTGKLGTYAAC 68
Query: 388 YGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGM 492
G E H+G +++ D+ YRE G RG+
Sbjct: 69 IGHEATHVGIGASMRSGDVFAPSYREYGTMFERGV 103
>UniRef50_Q6A611 Cluster: Pyruvate dehydrogenase E1 component, alpha
subunit; n=1; Propionibacterium acnes|Rep: Pyruvate
dehydrogenase E1 component, alpha subunit -
Propionibacterium acnes
Length = 381
Score = 41.5 bits (93), Expect = 0.015
Identities = 29/121 (23%), Positives = 53/121 (43%), Gaps = 1/121 (0%)
Frame = +1
Query: 151 GARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEP-NLDKATLINMYKTMVQLSH 327
G P+V + +P + R++D G++ + P +L L+ + MV
Sbjct: 10 GGTDPFVLPARQHPVNRPDPAMV-RILDEQGRLTTHPDFPVDLVDDDLVKALEMMVMTRR 68
Query: 328 MDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTEL 507
+D QR G + + G+E G+ AL D VF YRE G+ G+++ ++
Sbjct: 69 LDVEATALQRHGELGLWPPLLGQEATQAGAWLALREGDQVFPTYREQGLAHAMGVSLADI 128
Query: 508 V 510
+
Sbjct: 129 L 129
>UniRef50_O96865 Cluster: Pyruvate dehydrogenase E1 alpha subunit;
n=2; Trypanosoma cruzi|Rep: Pyruvate dehydrogenase E1
alpha subunit - Trypanosoma cruzi
Length = 378
Score = 40.7 bits (91), Expect = 0.027
Identities = 24/94 (25%), Positives = 48/94 (51%), Gaps = 1/94 (1%)
Frame = +1
Query: 310 MVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPKDLVFSQYREVGVFLYR 486
M ++ M+ + +S + +I + Y G+E I +G + L+ +DL+ + YR+ ++ R
Sbjct: 54 MFRIRRMESLCDQSYKLKKIRGFCHLYIGQEAIPVGMENVLTLEDLIVTAYRDHAWYIVR 113
Query: 487 GMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHN 588
G T E+ + +G KG+ +H S +N
Sbjct: 114 GGTPGEVFAEMFGKEGGCSKGKGGSMHMYSVKNN 147
>UniRef50_Q13GQ3 Cluster: Putative 2-oxo acid dehydrogenase alpha
subunit; n=1; Burkholderia xenovorans LB400|Rep:
Putative 2-oxo acid dehydrogenase alpha subunit -
Burkholderia xenovorans (strain LB400)
Length = 334
Score = 40.3 bits (90), Expect = 0.036
Identities = 27/98 (27%), Positives = 45/98 (45%), Gaps = 1/98 (1%)
Frame = +1
Query: 277 DKATLINMYKTMVQLSHMDKILYESQRQGRI-SFYMTNYGEEGIHIGSASALSPKDLVFS 453
D+ LI++Y+TMV + ++ L + F + G+E + G AS L +D + +
Sbjct: 15 DRRKLIDIYRTMVLVREVELSLSRLFADSEVPGFIHLSLGQEAVSAGVASVLEVQDTLAT 74
Query: 454 QYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVH 567
+R G L RG+ V + G KGR +H
Sbjct: 75 THRGHGHVLARGIDVGGFFKEIMGRVGGLCKGRGGSMH 112
>UniRef50_Q2JA37 Cluster: Pyruvate dehydrogenase; n=11;
Actinomycetales|Rep: Pyruvate dehydrogenase - Frankia
sp. (strain CcI3)
Length = 388
Score = 39.9 bits (89), Expect = 0.047
Identities = 22/73 (30%), Positives = 35/73 (47%), Gaps = 3/73 (4%)
Frame = +1
Query: 355 RQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCE 534
RQGR++ Y + G+E I +A L D +F YR+ + RG+ + + GN
Sbjct: 73 RQGRLAVYPASTGQEACQIAAAMVLRESDWLFPSYRDTLAVVSRGVRPVDALTLMRGNAH 132
Query: 535 ---DPGKGRQMPV 564
DP + R P+
Sbjct: 133 SGYDPREHRIAPL 145
>UniRef50_Q2BFQ9 Cluster: Putative uncharacterized protein; n=1;
Bacillus sp. NRRL B-14911|Rep: Putative uncharacterized
protein - Bacillus sp. NRRL B-14911
Length = 668
Score = 39.9 bits (89), Expect = 0.047
Identities = 26/108 (24%), Positives = 52/108 (48%), Gaps = 3/108 (2%)
Frame = +1
Query: 274 LDKATLINMYKTMVQLSHMDKILYESQRQGRI-SFYMTNYGEEGIHIGSASALSPKDLVF 450
L + T+ +MYK M+ + +++ L + +G + T+ G+E + S + + D+VF
Sbjct: 14 LSQETIDSMYKKMITIRTLEETLLDLFSKGELFGTTHTSIGQEANAVASMAHIKNGDVVF 73
Query: 451 SQYREVGVFLYRGMTVTELVNQCYGNCED--PGKGRQMPVHYGSKHHN 588
S +R G ++ G V +L+ + G G+G + Y + N
Sbjct: 74 SNHRCHGHYIAYGAPVDQLIAEVMGRVTGVVGGRGGSQHICYNDFYTN 121
>UniRef50_Q6NX32 Cluster: Pyruvate dehydrogenase (Lipoamide) alpha
1; n=3; Tetrapoda|Rep: Pyruvate dehydrogenase
(Lipoamide) alpha 1 - Xenopus tropicalis (Western clawed
frog) (Silurana tropicalis)
Length = 369
Score = 39.1 bits (87), Expect = 0.082
Identities = 25/98 (25%), Positives = 48/98 (48%), Gaps = 1/98 (1%)
Frame = +1
Query: 292 INMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPKDLVFSQYREV 468
+ Y+TM + M+ + +Q I + Y G+E +G +A++P D + + YR
Sbjct: 72 LQYYRTMQTIRRMELKSDQLYKQKIIRGFCHLYDGQEACCVGLEAAINPTDHLITAYRAH 131
Query: 469 GVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKH 582
G RG++V E++ + G KG+ +H +K+
Sbjct: 132 GYSYTRGVSVKEILAELTGRRGGCAKGKGGSMHMYAKN 169
>UniRef50_A4X7T3 Cluster: Dehydrogenase, E1 component; n=3;
Actinomycetales|Rep: Dehydrogenase, E1 component -
Salinispora tropica CNB-440
Length = 323
Score = 39.1 bits (87), Expect = 0.082
Identities = 25/93 (26%), Positives = 43/93 (46%), Gaps = 1/93 (1%)
Frame = +1
Query: 292 INMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPKDLVFSQYREV 468
+ +Y+T+ + ++ E R G I + Y G+EGI G +AL P D+V +R
Sbjct: 7 VRLYRTVRLIRRFEERAIELVRSGHIVGGIHPYVGQEGIAAGVCAALRPDDVVAGTHRGH 66
Query: 469 GVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVH 567
G L +G ++ + G +GR +H
Sbjct: 67 GHVLAKGADPARMMAELCGRVTGLNRGRGGSMH 99
>UniRef50_Q5LVW0 Cluster: Dehydrogenase/transketolase family
protein; n=23; Proteobacteria|Rep:
Dehydrogenase/transketolase family protein -
Silicibacter pomeroyi
Length = 740
Score = 37.5 bits (83), Expect = 0.25
Identities = 21/77 (27%), Positives = 37/77 (48%)
Frame = +1
Query: 268 PNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLV 447
P L +A +++Y+ V +D+ Q+ G+ + + + G EG+ A AL P D+
Sbjct: 38 PGLTQAQAVSLYRAQVLSRALDRTSRAMQKAGQGFYTIGSSGHEGM-AAVAQALRPTDIA 96
Query: 448 FSQYREVGVFLYRGMTV 498
F YR+ + R V
Sbjct: 97 FLHYRDAAFQIARAEQV 113
>UniRef50_A6GG24 Cluster: Pyruvate dehydrogenase (Lipoamide), alpha
subunit; n=1; Plesiocystis pacifica SIR-1|Rep: Pyruvate
dehydrogenase (Lipoamide), alpha subunit - Plesiocystis
pacifica SIR-1
Length = 339
Score = 37.5 bits (83), Expect = 0.25
Identities = 22/98 (22%), Positives = 44/98 (44%), Gaps = 1/98 (1%)
Frame = +1
Query: 280 KATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPKDLVFSQ 456
K + ++ M+++ ++ + +G+IS ++ Y G+E I +G A+ D V
Sbjct: 19 KDETLKAFREMLRIRRFEETAARAYTRGKISGFLHLYIGQEAIAVGVKLAMQANDRVVGT 78
Query: 457 YREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHY 570
YR+ G L +G + + +G G +HY
Sbjct: 79 YRDHGYALAQGSDANACMAELFGKATGLVGGVGGSMHY 116
>UniRef50_UPI0000E4A5CB Cluster: PREDICTED: hypothetical protein,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: hypothetical protein, partial -
Strongylocentrotus purpuratus
Length = 378
Score = 37.1 bits (82), Expect = 0.33
Identities = 29/119 (24%), Positives = 51/119 (42%), Gaps = 5/119 (4%)
Frame = +1
Query: 274 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPKDLVF 450
L K ++ Y M + M+ + + + Y G+E +G +S L+P D V
Sbjct: 181 LTKDEALDYYHKMQTIRRMETAAATLYKSKEVRGFCHLYSGQEACAVGISSVLTPDDAVI 240
Query: 451 SQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKH----HNMVTISSPLG 615
+ YR G RG+T+ ++ + G KG+ +H K+ + +V PLG
Sbjct: 241 TAYRAHGWAYLRGVTLHGVLAELTGRRTGCAKGKGGSMHMYCKNFYGGNGIVGAQVPLG 299
>UniRef50_Q4T3C0 Cluster: Chromosome undetermined SCAF10102, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF10102,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 491
Score = 36.7 bits (81), Expect = 0.44
Identities = 23/89 (25%), Positives = 43/89 (48%), Gaps = 1/89 (1%)
Frame = +1
Query: 262 EEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPK 438
E+ L + + Y+TM + M+ + +Q I + Y G+E G +A++P
Sbjct: 14 EKAELTREQGLQYYRTMQTIRRMELKADQLYKQKIIRGFCHLYDGQEACAAGIEAAITPS 73
Query: 439 DLVFSQYREVGVFLYRGMTVTELVNQCYG 525
D + + YR G RG++V E++ + G
Sbjct: 74 DHLITAYRAHGYTFTRGVSVKEILAELTG 102
>UniRef50_Q1ATM5 Cluster: Pyruvate dehydrogenase; n=1; Rubrobacter
xylanophilus DSM 9941|Rep: Pyruvate dehydrogenase -
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 353
Score = 36.7 bits (81), Expect = 0.44
Identities = 25/94 (26%), Positives = 41/94 (43%), Gaps = 1/94 (1%)
Frame = +1
Query: 289 LINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPKDLVFSQYRE 465
L +Y MV + + + RQG+I Y+ Y G+E + G A D V + YR+
Sbjct: 28 LAELYGKMVLIRAFEDACQRAFRQGKIGGYLHVYTGQEAVATGFLEAFREGDRVITGYRD 87
Query: 466 VGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVH 567
L G E++ + +G KG+ +H
Sbjct: 88 HAHALLLGCDPKEVMAELFGKRTGLVKGKGGSMH 121
>UniRef50_Q97YF6 Cluster: Pyruvate dehydrogenase, alpha subunit
(Lipoamide); n=2; Sulfolobaceae|Rep: Pyruvate
dehydrogenase, alpha subunit (Lipoamide) - Sulfolobus
solfataricus
Length = 345
Score = 36.3 bits (80), Expect = 0.58
Identities = 26/119 (21%), Positives = 53/119 (44%), Gaps = 10/119 (8%)
Frame = +1
Query: 262 EEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMT----------NYGEEGIHI 411
E L + L+NMYK M+ + + ++ + + +G+ F M + G+E + +
Sbjct: 17 ENAGLKASDLLNMYKRMLIIRYFEESIRKIYHEGKNPFNMASGRIRGEMHLSIGQEAVAV 76
Query: 412 GSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHN 588
G+ + +D+V S +R + +G+ + L + G KG+ +H K N
Sbjct: 77 GTLYDIRDEDVVVSTHRPHHHAIAKGVDLKGLAAEILGKATGLCKGKGGHMHLFDKSKN 135
>UniRef50_Q8H1Y0 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha-2, mitochondrial precursor; n=33; cellular
organisms|Rep: Pyruvate dehydrogenase E1 component
subunit alpha-2, mitochondrial precursor - Arabidopsis
thaliana (Mouse-ear cress)
Length = 393
Score = 35.9 bits (79), Expect = 0.77
Identities = 20/81 (24%), Positives = 38/81 (46%), Gaps = 6/81 (7%)
Frame = +1
Query: 391 GEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHY 570
G+E + +G +A++ KD + + YR+ F+ RG + + ++ G G+ +H+
Sbjct: 98 GQEALAVGMEAAITKKDAIITSYRDHCTFIGRGGKLVDAFSELMGRKTGCSHGKGGSMHF 157
Query: 571 GSKH------HNMVTISSPLG 615
K H +V PLG
Sbjct: 158 YKKDASFYGGHGIVGAQIPLG 178
>UniRef50_A6UDY5 Cluster: Dehydrogenase E1 component; n=2;
Alphaproteobacteria|Rep: Dehydrogenase E1 component -
Sinorhizobium medicae WSM419
Length = 342
Score = 35.1 bits (77), Expect = 1.3
Identities = 27/98 (27%), Positives = 49/98 (50%), Gaps = 6/98 (6%)
Frame = +1
Query: 289 LINMYKTMVQLSHMDKILYESQRQGRISFYMTNY--GEEGIHIGSASALSPKDLVFSQYR 462
L+ +Y+TM ++ ++ + E +G+ + M + GEE G +A+ P+D + +R
Sbjct: 9 LLELYRTMRRIRTFEERVGELFVRGQSAGSMLHLSIGEESSAAGVCAAMKPQDTFTTHHR 68
Query: 463 EVGVFLYRG----MTVTELVNQCYGNCEDPGKGRQMPV 564
G+FL RG + E+ + G C GKG M +
Sbjct: 69 GHGIFLARGADPKRMMAEIGGKETGYCR--GKGGSMHI 104
>UniRef50_P08559 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha, somatic form, mitochondrial precursor;
n=110; cellular organisms|Rep: Pyruvate dehydrogenase E1
component subunit alpha, somatic form, mitochondrial
precursor - Homo sapiens (Human)
Length = 390
Score = 35.1 bits (77), Expect = 1.3
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Frame = +1
Query: 391 GEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHY 570
G+E +G + ++P D + + YR G RG++V E++ + G KG+ +H
Sbjct: 96 GQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHM 155
Query: 571 GSKH----HNMVTISSPLG 615
+K+ + +V PLG
Sbjct: 156 YAKNFYGGNGIVGAQVPLG 174
>UniRef50_Q4Z3X1 Cluster: Putative uncharacterized protein; n=4;
Plasmodium (Vinckeia)|Rep: Putative uncharacterized
protein - Plasmodium berghei
Length = 918
Score = 34.7 bits (76), Expect = 1.8
Identities = 19/65 (29%), Positives = 34/65 (52%)
Frame = +1
Query: 286 TLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYRE 465
TL N+Y+T + L ++ L+ RI Y NY + IH ++ K+ +F+Q +
Sbjct: 854 TLQNIYRTYIFLFLIENFLFIFSNNNRIYVYAINYENKNIHF--LKSVKIKNCIFNQINQ 911
Query: 466 VGVFL 480
+ +FL
Sbjct: 912 I-IFL 915
>UniRef50_Q5FNM5 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit; n=4; Bacteria|Rep: Pyruvate dehydrogenase E1
component alpha subunit - Gluconobacter oxydans
(Gluconobacter suboxydans)
Length = 334
Score = 34.3 bits (75), Expect = 2.3
Identities = 25/118 (21%), Positives = 47/118 (39%), Gaps = 1/118 (0%)
Frame = +1
Query: 229 MDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGI 405
MD ++ P L T+ Y+ M+ + ++ + G I + Y G+E +
Sbjct: 1 MDETPSASGRSNGPALSPETMKRAYRDMLLVRRFEEKAGQLYGMGLIGGFCHLYIGQEAV 60
Query: 406 HIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSK 579
+G + D + YR+ G L GMT ++ + G G+ +H S+
Sbjct: 61 VVGIGLNMKQGDKSITSYRDHGQMLVAGMTPRGVMAELTGRSGGYSHGKGGSMHMFSR 118
>UniRef50_Q2ITF8 Cluster: Acetoin dehydrogenase (TPP-dependent)
alpha chain; n=1; Rhodopseudomonas palustris HaA2|Rep:
Acetoin dehydrogenase (TPP-dependent) alpha chain -
Rhodopseudomonas palustris (strain HaA2)
Length = 323
Score = 33.9 bits (74), Expect = 3.1
Identities = 15/59 (25%), Positives = 30/59 (50%)
Frame = +1
Query: 391 GEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVH 567
G+E + + +AL P DL S +R +L +G ++ ++ + YG +G+ +H
Sbjct: 40 GQEAVAAAAGAALEPADLAVSGHRAHAHYLAKGGSLKAMIAEIYGRVTGCSRGKGGSMH 98
>UniRef50_Q2AD68 Cluster: Putative uncharacterized protein; n=1;
Halothermothrix orenii H 168|Rep: Putative
uncharacterized protein - Halothermothrix orenii H 168
Length = 242
Score = 33.9 bits (74), Expect = 3.1
Identities = 27/92 (29%), Positives = 48/92 (52%), Gaps = 2/92 (2%)
Frame = +1
Query: 130 GKIAEFPGARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKN-EEPNLDKATLINMYK 306
GKI+ P +++ V T YE +P+ + D G I++ N +E NLDK L N K
Sbjct: 150 GKISVIPRSQSRAVRPKDLKINTGYEGLPVIVIED--GNILEDNLKENNLDKNWLKNQLK 207
Query: 307 TMVQLSHMDKILYES-QRQGRISFYMTNYGEE 399
+ +++++L QGR+ Y++ G++
Sbjct: 208 QQ-GIDNVEEVLVGMLDTQGRL--YISKKGQK 236
>UniRef50_A7BPK6 Cluster: Pyruvate dehydrogenase; n=1; Beggiatoa sp.
PS|Rep: Pyruvate dehydrogenase - Beggiatoa sp. PS
Length = 331
Score = 33.9 bits (74), Expect = 3.1
Identities = 19/95 (20%), Positives = 47/95 (49%), Gaps = 2/95 (2%)
Frame = +1
Query: 289 LINMYKTMVQLSHMDKILYE--SQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYR 462
L+ Y++++ + +++ + E ++++ R ++ G+E + +G L D +FS +R
Sbjct: 16 LLTFYRSLLLIRRVEEAIAERYTEQEMRCPTHLC-IGQEAVAVGVCKMLQQSDGIFSSHR 74
Query: 463 EVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVH 567
+L +G + ++ + YG GR +H
Sbjct: 75 AHSHYLAKGGDLKAMIAELYGKSTGCCGGRGGSMH 109
>UniRef50_Q5DY55 Cluster: Putative uncharacterized protein; n=1;
Vibrio fischeri ES114|Rep: Putative uncharacterized
protein - Vibrio fischeri (strain ATCC 700601 / ES114)
Length = 147
Score = 33.5 bits (73), Expect = 4.1
Identities = 29/91 (31%), Positives = 42/91 (46%), Gaps = 5/91 (5%)
Frame = +1
Query: 133 KIAEFPGARAPYVSEMKFF---NETSYEPIPIYR-VMDNNGQIIDKNEEPNLDKATLINM 300
K + G R P KF N+ + E R + N II K EE ++DK LI +
Sbjct: 37 KSTTYVGFRLPNDEHEKFTAKANKANMELTEFLREAILKNKTIIVKKEERSVDKQKLIFL 96
Query: 301 Y-KTMVQLSHMDKILYESQRQGRISFYMTNY 390
Y KT L+ + K ++ S R G +S N+
Sbjct: 97 YKKTSNNLNQLAKQIHTSNRAGTLSREKMNH 127
>UniRef50_Q2S150 Cluster: Pyruvate dehydrogenase E1 component, alpha
subunit; n=1; Salinibacter ruber DSM 13855|Rep: Pyruvate
dehydrogenase E1 component, alpha subunit - Salinibacter
ruber (strain DSM 13855)
Length = 470
Score = 33.5 bits (73), Expect = 4.1
Identities = 23/114 (20%), Positives = 54/114 (47%), Gaps = 2/114 (1%)
Frame = +1
Query: 259 NEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALS- 432
++E + ++++ + M+ + + ++ +IS ++ Y G+E + GS +A+
Sbjct: 140 HDELGIADDEVLDLLRNMLLQRRFENRCRQMYQRQKISGFLHLYIGQEAVSTGSVNAIEL 199
Query: 433 PKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMV 594
D V + YR+ G+ L G+T + + +G KG+ +H+ M+
Sbjct: 200 GDDSVITAYRDHGMGLAMGITPEAGMAELFGKETGCSKGKGGSMHFFDAEKKMM 253
>UniRef50_Q0ET31 Cluster: Dehydrogenase, E1 component; n=1;
Thermoanaerobacter ethanolicus X514|Rep: Dehydrogenase,
E1 component - Thermoanaerobacter ethanolicus X514
Length = 262
Score = 33.5 bits (73), Expect = 4.1
Identities = 23/110 (20%), Positives = 48/110 (43%), Gaps = 11/110 (10%)
Frame = +1
Query: 271 NLDKATLINMYKTMVQLSHMDKILYESQRQGRISFY-----------MTNYGEEGIHIGS 417
N+ K TLI MY MV + ++ + E+ ++G+ + G+E + +G
Sbjct: 2 NIPKETLIRMYLEMVTIRLYEETMAEAYQEGKYPVFNIASGPVPGEMHLAAGQEPVAVGV 61
Query: 418 ASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVH 567
L +D V +R + +G+ + + + +G G+G+ +H
Sbjct: 62 CMHLKKEDAVVGTHRPHHFAIAKGVDLKRMTAEIFGKVTGLGRGKGGHMH 111
>UniRef50_A6Q3I6 Cluster: Pyruvate/2-oxoglutarate dehydrogenase
complex, E1 component, alpha subunit; n=2; unclassified
Epsilonproteobacteria|Rep: Pyruvate/2-oxoglutarate
dehydrogenase complex, E1 component, alpha subunit -
Nitratiruptor sp. (strain SB155-2)
Length = 323
Score = 33.5 bits (73), Expect = 4.1
Identities = 21/71 (29%), Positives = 35/71 (49%), Gaps = 1/71 (1%)
Frame = +1
Query: 358 QGRIS-FYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCE 534
+G I+ F + G+E +GS A D VF+ YRE + + RGM ++ + +G
Sbjct: 29 KGNIAGFLHLDIGQEACSVGSMQAFDKGD-VFTHYREHVLAIARGMDPKVVMAELFGKVT 87
Query: 535 DPGKGRQMPVH 567
KG+ +H
Sbjct: 88 GISKGKGGSMH 98
>UniRef50_A3ZN48 Cluster: Putative uncharacterized protein; n=1;
Blastopirellula marina DSM 3645|Rep: Putative
uncharacterized protein - Blastopirellula marina DSM
3645
Length = 254
Score = 33.5 bits (73), Expect = 4.1
Identities = 15/38 (39%), Positives = 23/38 (60%), Gaps = 1/38 (2%)
Frame = +3
Query: 474 VFIPRD-DCDGTCEPVLRKLRGSGERETDAGPLRKQAP 584
+++P D DG +P+L L G+GER TD ++K P
Sbjct: 55 LYLPTDYKADGESKPLLLFLHGAGERGTDLNQVKKHGP 92
>UniRef50_Q4QDQ1 Cluster: Pyruvate dehydrogenase E1 component alpha
subunit, putative; n=5; Euglenozoa|Rep: Pyruvate
dehydrogenase E1 component alpha subunit, putative -
Leishmania major
Length = 378
Score = 33.5 bits (73), Expect = 4.1
Identities = 20/87 (22%), Positives = 43/87 (49%), Gaps = 1/87 (1%)
Frame = +1
Query: 310 MVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPKDLVFSQYREVGVFLYR 486
M ++ M+ + +S + +I + Y G+E I G + L+ +D + + YR+ G ++ R
Sbjct: 54 MFRIRRMESLCDQSYKLKKIRGFCHLYIGQEAIPAGMENVLTFEDPIITGYRDHGWYISR 113
Query: 487 GMTVTELVNQCYGNCEDPGKGRQMPVH 567
G ++ + +G KG+ +H
Sbjct: 114 GGKPEDVFAEMFGRQGGCSKGKGGSMH 140
>UniRef50_Q9R9N5 Cluster: Pyruvate dehydrogenase E1 component
subunit alpha; n=62; Bacteria|Rep: Pyruvate
dehydrogenase E1 component subunit alpha - Rhizobium
meliloti (Sinorhizobium meliloti)
Length = 348
Score = 33.5 bits (73), Expect = 4.1
Identities = 24/97 (24%), Positives = 43/97 (44%), Gaps = 1/97 (1%)
Frame = +1
Query: 292 INMYKTMVQLSHMDKILYESQRQGRISFYMTNY-GEEGIHIGSASALSPKDLVFSQYREV 468
+ Y+ M+ + ++ + G I + Y G+E + +G AL D V + YR+
Sbjct: 37 LKAYREMLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVVGMQLALKEGDQVITGYRDH 96
Query: 469 GVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSK 579
G L GM+ ++ + G KG+ +H SK
Sbjct: 97 GHMLACGMSARGVMAELTGRRGGLSKGKGGSMHMFSK 133
>UniRef50_Q0RVK8 Cluster: Probable pyruvate dehydrogenase; n=1;
Rhodococcus sp. RHA1|Rep: Probable pyruvate
dehydrogenase - Rhodococcus sp. (strain RHA1)
Length = 344
Score = 33.1 bits (72), Expect = 5.4
Identities = 22/96 (22%), Positives = 41/96 (42%), Gaps = 1/96 (1%)
Frame = +1
Query: 283 ATLINMYKTMVQLSHMDKILYESQRQGRIS-FYMTNYGEEGIHIGSASALSPKDLVFSQY 459
A L++ Y+ MV ++ L G++ ++ + G E +A+ + D + +
Sbjct: 27 ADLLSTYRLMVLAREFEEQLGAIFAAGKLGGWFHSCIGHEATGAAAAALMRETDHLVPYH 86
Query: 460 REVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVH 567
R L +GMT +L + G P +GR H
Sbjct: 87 RSRVSILGKGMTARDLAMEIMGRATAPSRGRAGETH 122
>UniRef50_A2TU24 Cluster: (Pyruvate) Oxoisovalerate Dehydrogenase
Alpha and Beta Fusion; n=6; cellular organisms|Rep:
(Pyruvate) Oxoisovalerate Dehydrogenase Alpha and Beta
Fusion - Dokdonia donghaensis MED134
Length = 693
Score = 33.1 bits (72), Expect = 5.4
Identities = 18/55 (32%), Positives = 25/55 (45%)
Frame = +1
Query: 376 YMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDP 540
+ T+ G E I L P+D F YR+ + L GM EL+ Q +DP
Sbjct: 35 HATSRGHEVIQTAIGMQLQPQDYAFPYYRDDSMLLAIGMKPYELMLQVLAKKDDP 89
>UniRef50_Q630X8 Cluster: Hypothetical and glycosyltransferase
fusion protein; n=1; Bacillus cereus E33L|Rep:
Hypothetical and glycosyltransferase fusion protein -
Bacillus cereus (strain ZK / E33L)
Length = 1176
Score = 32.7 bits (71), Expect = 7.1
Identities = 20/63 (31%), Positives = 32/63 (50%), Gaps = 1/63 (1%)
Frame = +1
Query: 274 LDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIH-IGSASALSPKDLVF 450
L K TL N K L H + ++ES+ G Y++ + + GIH + S L PKD +
Sbjct: 336 LSKETLFNWEKDNKILYHDAQNVFESRLIGNQFVYVSCFEDIGIHEVSEKSLLHPKDKYY 395
Query: 451 SQY 459
++
Sbjct: 396 YEF 398
>UniRef50_A4XF89 Cluster: Dehydrogenase, E1 component; n=1;
Novosphingobium aromaticivorans DSM 12444|Rep:
Dehydrogenase, E1 component - Novosphingobium
aromaticivorans (strain DSM 12444)
Length = 315
Score = 32.7 bits (71), Expect = 7.1
Identities = 25/98 (25%), Positives = 44/98 (44%), Gaps = 3/98 (3%)
Frame = +1
Query: 277 DKATLINMYKTMVQLSHMDKILYESQRQGRIS-FYMTNYGEEGIHIGSASALSPKDLVFS 453
D A L +M+ + ++ ++ R+ R S ++ G+E IG+ +AL D V+
Sbjct: 5 DPALLESMFHKLAVSRAVETLMLRHTREERFSGWWHPGEGQEAAPIGATAALEADDYVWY 64
Query: 454 QYREVGVFLYRGMTVTELVNQCYG--NCEDPGKGRQMP 561
Q R + +GM ++ G N GKG +P
Sbjct: 65 QGRGCAWAIGKGMDPLPILGDLLGKTNGATGGKGGGVP 102
>UniRef50_A3PXW7 Cluster: Transketolase domain protein; n=4;
Mycobacterium|Rep: Transketolase domain protein -
Mycobacterium sp. (strain JLS)
Length = 721
Score = 32.7 bits (71), Expect = 7.1
Identities = 21/70 (30%), Positives = 32/70 (45%)
Frame = +1
Query: 289 LINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREV 468
L+ ++ + H+D + QGR + + + G EG + A+AL P D YR
Sbjct: 35 LLALFDVALASRHLDLAARWLRAQGRGYYTIGSSGHEG-NAAVAAALRPTDPALLHYRSG 93
Query: 469 GVFLYRGMTV 498
G FL R V
Sbjct: 94 GFFLARAQQV 103
>UniRef50_UPI0000E0F4CE Cluster: co-chaperone HscB; n=1; alpha
proteobacterium HTCC2255|Rep: co-chaperone HscB - alpha
proteobacterium HTCC2255
Length = 176
Score = 32.3 bits (70), Expect = 9.4
Identities = 15/34 (44%), Positives = 21/34 (61%)
Frame = +1
Query: 271 NLDKATLINMYKTMVQLSHMDKILYESQRQGRIS 372
NLDKA L Y+ + QL+H DK S ++ RI+
Sbjct: 18 NLDKAQLSRAYQALQQLTHPDKFASGSDQEKRIA 51
>UniRef50_Q7RL33 Cluster: Putative uncharacterized protein PY02714;
n=5; Plasmodium (Vinckeia)|Rep: Putative uncharacterized
protein PY02714 - Plasmodium yoelii yoelii
Length = 1486
Score = 32.3 bits (70), Expect = 9.4
Identities = 17/55 (30%), Positives = 30/55 (54%)
Frame = +1
Query: 190 NETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQ 354
N+ + Y +M+ + D + E L K +N+YK + +LS+ +KI YES+
Sbjct: 567 NDQIFSTNNAYVIMNVFFKTKDFDHEAELMKYNNLNLYKQLYKLSNKEKIFYESR 621
>UniRef50_P31334 Cluster: 54S ribosomal protein L9, mitochondrial
precursor; n=6; Saccharomycetales|Rep: 54S ribosomal
protein L9, mitochondrial precursor - Saccharomyces
cerevisiae (Baker's yeast)
Length = 269
Score = 32.3 bits (70), Expect = 9.4
Identities = 20/71 (28%), Positives = 34/71 (47%), Gaps = 5/71 (7%)
Frame = +1
Query: 385 NYGEEGIHIGSASALSPKDL--VFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGK---G 549
++ +EG ++ S K V +Y G+ G ++ YG +DPG+ G
Sbjct: 158 SFFKEGQYVDVRSVSKGKGFTGVMKRYGFKGLRASHGTSIMHRHGGSYGQNQDPGRVLPG 217
Query: 550 RQMPVHYGSKH 582
R+MP H G++H
Sbjct: 218 RKMPGHMGNEH 228
>UniRef50_O14618 Cluster: Copper chaperone for superoxide dismutase;
n=24; Euteleostomi|Rep: Copper chaperone for superoxide
dismutase - Homo sapiens (Human)
Length = 274
Score = 32.3 bits (70), Expect = 9.4
Identities = 24/67 (35%), Positives = 30/67 (44%), Gaps = 5/67 (7%)
Frame = +3
Query: 381 DQLRRGGHPHRQRLGTLTERFGLQSIQRSRSVF-IPRD--DCDGTC--EPVLRKLRGSGE 545
D L RGGHP + G ER I RS +F P+ CDG E R + G G
Sbjct: 205 DDLGRGGHPLSKITGNSGERLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGKGR 264
Query: 546 RETDAGP 566
+E+ P
Sbjct: 265 KESAQPP 271
>UniRef50_Q7TMA5 Cluster: Apolipoprotein B-100 precursor (Apo B-100)
[Contains: Apolipoprotein B-48 (Apo B-48)]; n=20;
Eukaryota|Rep: Apolipoprotein B-100 precursor (Apo B-100)
[Contains: Apolipoprotein B-48 (Apo B-48)] - Rattus
norvegicus (Rat)
Length = 4743
Score = 32.3 bits (70), Expect = 9.4
Identities = 21/68 (30%), Positives = 33/68 (48%), Gaps = 3/68 (4%)
Frame = +1
Query: 229 MDNNGQIIDKNEEPNLD---KATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEE 399
+D+ + K P LD KA+L N KT+++ HM + S G ++ N+ +E
Sbjct: 2845 LDSQTKYFHKLSVPRLDFSSKASLNNEIKTLLEAGHM---AWTSSGTGSWNWACPNFSDE 2901
Query: 400 GIHIGSAS 423
GIH S
Sbjct: 2902 GIHSSKIS 2909
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 643,353,652
Number of Sequences: 1657284
Number of extensions: 13152829
Number of successful extensions: 36500
Number of sequences better than 10.0: 136
Number of HSP's better than 10.0 without gapping: 35389
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 36471
length of database: 575,637,011
effective HSP length: 97
effective length of database: 414,880,463
effective search space used: 44392209541
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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