BLASTX 2.2.12 [Aug-07-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= fmgV10b24r (681 letters) Database: uniref50 1,657,284 sequences; 575,637,011 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value UniRef50_UPI00015B4325 Cluster: PREDICTED: similar to aconitase,... 205 7e-52 UniRef50_Q9VIE8 Cluster: CG9244-PB; n=37; cellular organisms|Rep... 186 3e-46 UniRef50_Q99798 Cluster: Aconitate hydratase, mitochondrial prec... 167 2e-40 UniRef50_O75944 Cluster: Aconitase; n=34; cellular organisms|Rep... 160 3e-38 UniRef50_P19414 Cluster: Aconitate hydratase, mitochondrial prec... 151 2e-35 UniRef50_Q0CSK9 Cluster: Aconitate hydratase, mitochondrial; n=2... 148 1e-34 UniRef50_O13966 Cluster: Aconitate hydratase, mitochondrial prec... 144 2e-33 UniRef50_A0RTP9 Cluster: 3-isopropylmalate isomerase/aconitase A... 135 8e-31 UniRef50_Q2UTF0 Cluster: Aconitase/homoaconitase; n=9; cellular ... 128 1e-28 UniRef50_Q0USA6 Cluster: Putative uncharacterized protein; n=2; ... 113 5e-24 UniRef50_Q4PB22 Cluster: Putative uncharacterized protein; n=5; ... 84 3e-15 UniRef50_Q74AD1 Cluster: Aconitate hydratase, putative; n=12; Ba... 81 2e-14 UniRef50_Q5NTF8 Cluster: Aconitase; n=1; uncultured bacterium|Re... 81 2e-14 UniRef50_Q7NDZ5 Cluster: Aconitate hydratase; n=28; Bacteria|Rep... 72 1e-11 UniRef50_O67656 Cluster: Aconitase; n=17; cellular organisms|Rep... 71 3e-11 UniRef50_Q9I3F5 Cluster: Aconitate hydratase 1; n=98; Bacteria|R... 64 4e-09 UniRef50_Q0PQM5 Cluster: Aconitase A; n=1; Endoriftia persephone... 62 1e-08 UniRef50_Q0ADB7 Cluster: Aconitate hydratase 1; n=5; Bacteria|Re... 59 1e-07 UniRef50_A4FHT3 Cluster: Aconitate hydratase 1; n=2; Actinomycet... 56 8e-07 UniRef50_Q5V0F1 Cluster: Aconitate hydratase; n=8; cellular orga... 51 3e-05 UniRef50_A7CSQ0 Cluster: Aconitate hydratase 1; n=1; Opitutaceae... 47 5e-04 UniRef50_A1W553 Cluster: Aconitate hydratase 1 precursor; n=8; P... 46 9e-04 UniRef50_Q0ZQ48 Cluster: FrbA; n=6; cellular organisms|Rep: FrbA... 45 0.001 UniRef50_Q5P0Q2 Cluster: Aconitase; n=4; Proteobacteria|Rep: Aco... 44 0.005 UniRef50_O08451 Cluster: Aconitate hydratase; n=21; Bacteria|Rep... 43 0.008 UniRef50_Q125M5 Cluster: Aconitate hydratase-like; n=8; Proteoba... 42 0.014 UniRef50_P21399 Cluster: Iron-responsive element-binding protein... 41 0.032 UniRef50_Q42560 Cluster: Aconitate hydratase 1; n=35; cellular o... 41 0.032 UniRef50_A5WEQ7 Cluster: 2-methylisocitrate dehydratase, Fe/S-de... 40 0.042 UniRef50_Q8NQ98 Cluster: Aconitate hydratase; n=10; Bacteria|Rep... 40 0.042 UniRef50_Q7WB80 Cluster: Aconitate hydratase; n=3; Bordetella|Re... 38 0.30 UniRef50_Q098V5 Cluster: Aconitase; n=1; Stigmatella aurantiaca ... 37 0.40 UniRef50_A5C294 Cluster: Putative uncharacterized protein; n=1; ... 37 0.40 UniRef50_Q9RNH9 Cluster: Aconitase; n=3; Bacteria|Rep: Aconitase... 37 0.52 UniRef50_Q9L1C2 Cluster: Putative phosphatase; n=1; Streptomyces... 37 0.52 UniRef50_Q4T087 Cluster: Chromosome undetermined SCAF11289, whol... 36 0.69 UniRef50_Q6NH63 Cluster: Aconitate hydratase; n=32; cellular org... 36 0.91 UniRef50_UPI00006CB1D5 Cluster: hypothetical protein TTHERM_0030... 36 1.2 UniRef50_Q59938 Cluster: Aconitate hydratase; n=356; cellular or... 35 1.6 UniRef50_Q4WBR0 Cluster: Aconitase family protein; n=7; Pezizomy... 33 4.9 UniRef50_Q5JE83 Cluster: Hypothetical membrane protein; n=1; The... 33 4.9 UniRef50_A3Q2Y8 Cluster: Von Willebrand factor, type A; n=5; Myc... 33 6.4 UniRef50_A3PL44 Cluster: Aminoglycoside phosphotransferase precu... 33 6.4 UniRef50_Q0G320 Cluster: Isopropylmalate isomerase small subunit... 33 8.5 UniRef50_A4SVJ3 Cluster: MotA/TolQ/ExbB proton channel; n=1; Pol... 33 8.5 UniRef50_Q0URF6 Cluster: Predicted protein; n=1; Phaeosphaeria n... 33 8.5 >UniRef50_UPI00015B4325 Cluster: PREDICTED: similar to aconitase, mitochondrial; n=1; Nasonia vitripennis|Rep: PREDICTED: similar to aconitase, mitochondrial - Nasonia vitripennis Length = 917 Score = 205 bits (501), Expect = 7e-52 Identities = 94/111 (84%), Positives = 102/111 (91%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNS 500 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANA+DYDKI+P DKI++LGL Sbjct: 807 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANASDYDKIQPTDKINILGLKD 866 Query: 499 LAPGKPVDCEIKHKDGSTDRIKLNHSLNDQQINWFKAGSALNRMKEIASGK 347 LAPGKPV CEIKHKDG D I LNH+LN+QQI WF+AGSALNRMKEIA+GK Sbjct: 867 LAPGKPVKCEIKHKDGKVDTITLNHTLNEQQIEWFRAGSALNRMKEIAAGK 917 >UniRef50_Q9VIE8 Cluster: CG9244-PB; n=37; cellular organisms|Rep: CG9244-PB - Drosophila melanogaster (Fruit fly) Length = 787 Score = 186 bits (454), Expect = 3e-46 Identities = 90/108 (83%), Positives = 96/108 (88%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNS 500 EHAALEPRHLGGRAIIVKSFARIHETNLKKQG+LPLTFAN ADYDKI+P KISLL L S Sbjct: 680 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFANPADYDKIQPTSKISLLNLKS 739 Query: 499 LAPGKPVDCEIKHKDGSTDRIKLNHSLNDQQINWFKAGSALNRMKEIA 356 LAPGKPVD EIK+ D +RIKLNH+LND QI WFKAGSALNRMKE+A Sbjct: 740 LAPGKPVDAEIKNGD-KVERIKLNHTLNDLQIGWFKAGSALNRMKELA 786 >UniRef50_Q99798 Cluster: Aconitate hydratase, mitochondrial precursor; n=28; cellular organisms|Rep: Aconitate hydratase, mitochondrial precursor - Homo sapiens (Human) Length = 780 Score = 167 bits (407), Expect = 2e-40 Identities = 75/107 (70%), Positives = 89/107 (83%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNS 500 EHAALEPRHLGGRAII KSFARIHETNLKKQG+LPLTFA+ ADY+KI P DK+++ GL Sbjct: 672 EHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGLKD 731 Query: 499 LAPGKPVDCEIKHKDGSTDRIKLNHSLNDQQINWFKAGSALNRMKEI 359 PGKP+ C IKH +G+ + I LNH+ N+ QI WF+AGSALNRMKE+ Sbjct: 732 FTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKEL 778 >UniRef50_O75944 Cluster: Aconitase; n=34; cellular organisms|Rep: Aconitase - Homo sapiens (Human) Length = 600 Score = 160 bits (389), Expect = 3e-38 Identities = 73/107 (68%), Positives = 89/107 (83%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNS 500 EHAALEPRHLGGRAII KSFARIHET +KKQG+LPLTFA+ +DY+KI P DK+++ GL Sbjct: 493 EHAALEPRHLGGRAIITKSFARIHET-IKKQGLLPLTFADPSDYNKIHPVDKLTIQGLKD 551 Query: 499 LAPGKPVDCEIKHKDGSTDRIKLNHSLNDQQINWFKAGSALNRMKEI 359 APGKP+ C IKH +G+ + I LNH+ N+ QI WF+AGSALNRMKE+ Sbjct: 552 FAPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKEL 598 >UniRef50_P19414 Cluster: Aconitate hydratase, mitochondrial precursor; n=41; cellular organisms|Rep: Aconitate hydratase, mitochondrial precursor - Saccharomyces cerevisiae (Baker's yeast) Length = 778 Score = 151 bits (366), Expect = 2e-35 Identities = 71/105 (67%), Positives = 80/105 (76%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNS 500 EHAALEPR LGG AII KSFARIHETNLKKQG+LPL F N ADYDKI PDD+I +LGL Sbjct: 669 EHAALEPRFLGGFAIITKSFARIHETNLKKQGLLPLNFKNPADYDKINPDDRIDILGLAE 728 Query: 499 LAPGKPVDCEIKHKDGSTDRIKLNHSLNDQQINWFKAGSALNRMK 365 LAPGKPV + K+G L H+ ND+QI WFK GSALN++K Sbjct: 729 LAPGKPVTMRVHPKNGKPWDAVLTHTFNDEQIEWFKYGSALNKIK 773 >UniRef50_Q0CSK9 Cluster: Aconitate hydratase, mitochondrial; n=2; Pezizomycotina|Rep: Aconitate hydratase, mitochondrial - Aspergillus terreus (strain NIH 2624) Length = 781 Score = 148 bits (358), Expect = 1e-34 Identities = 71/109 (65%), Positives = 83/109 (76%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNS 500 EHAALEPRHLGG AII +SFARIHETNLKKQGMLPLTFA+ ADYDKI+P+D + LL Sbjct: 672 EHAALEPRHLGGLAIITRSFARIHETNLKKQGMLPLTFADPADYDKIQPEDTVDLL-CTE 730 Query: 499 LAPGKPVDCEIKHKDGSTDRIKLNHSLNDQQINWFKAGSALNRMKEIAS 353 L GKP+ + K+GST +KLNH+ N+ QI WFK GSALN M A+ Sbjct: 731 LEVGKPMTLRVHPKNGSTFDVKLNHTFNESQIEWFKDGSALNTMARKAA 779 >UniRef50_O13966 Cluster: Aconitate hydratase, mitochondrial precursor; n=21; cellular organisms|Rep: Aconitate hydratase, mitochondrial precursor - Schizosaccharomyces pombe (Fission yeast) Length = 778 Score = 144 bits (348), Expect = 2e-33 Identities = 69/112 (61%), Positives = 81/112 (72%), Gaps = 1/112 (0%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNS 500 EHAALEPR+LGG A+I KSFARIHETNLKKQG+LPLTFA+ A YDKI P D + + GL + Sbjct: 667 EHAALEPRYLGGAAVITKSFARIHETNLKKQGLLPLTFADPAAYDKISPFDTVDIDGLTT 726 Query: 499 LAPGKPVDCEIKHKDGSTD-RIKLNHSLNDQQINWFKAGSALNRMKEIASGK 347 APGKP+ + DGS + KLNH+ N QI WFKAGSALN M + K Sbjct: 727 FAPGKPLTLVVHPADGSAEWSTKLNHTFNKDQIEWFKAGSALNHMANMHKQK 778 >UniRef50_A0RTP9 Cluster: 3-isopropylmalate isomerase/aconitase A; n=7; cellular organisms|Rep: 3-isopropylmalate isomerase/aconitase A - Cenarchaeum symbiosum Length = 754 Score = 135 bits (327), Expect = 8e-31 Identities = 61/106 (57%), Positives = 80/106 (75%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNS 500 EHAA+ PRHLG A+I +SFARIHETNLKKQG+L L F++ ADY+KI DD I+++GL S Sbjct: 648 EHAAMSPRHLGCAAVIARSFARIHETNLKKQGILALVFSDPADYEKILEDDTINIVGLKS 707 Query: 499 LAPGKPVDCEIKHKDGSTDRIKLNHSLNDQQINWFKAGSALNRMKE 362 +AP V C + H DGS D + L+HS + QI WF+AGSALN +++ Sbjct: 708 MAPHTHVKCLVVHADGSEDTLDLSHSYSASQIGWFRAGSALNVLRD 753 >UniRef50_Q2UTF0 Cluster: Aconitase/homoaconitase; n=9; cellular organisms|Rep: Aconitase/homoaconitase - Aspergillus oryzae Length = 806 Score = 128 bits (309), Expect = 1e-28 Identities = 62/113 (54%), Positives = 81/113 (71%), Gaps = 2/113 (1%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGL-- 506 EHAALEPR+LGG A+I +SFARIHETNLKKQGMLPLTF + DYD+I D+I+L G+ Sbjct: 694 EHAALEPRYLGGVAVIARSFARIHETNLKKQGMLPLTFDDPLDYDRILEGDRITLTGVED 753 Query: 505 NSLAPGKPVDCEIKHKDGSTDRIKLNHSLNDQQINWFKAGSALNRMKEIASGK 347 LAPG+ V + + G++ +LNHS + Q++W +AGSALN +K A K Sbjct: 754 GELAPGRQVTMRVTPRQGASWTAQLNHSYHAGQLHWLRAGSALNHIKNTALAK 806 >UniRef50_Q0USA6 Cluster: Putative uncharacterized protein; n=2; Pezizomycotina|Rep: Putative uncharacterized protein - Phaeosphaeria nodorum (Septoria nodorum) Length = 781 Score = 113 bits (271), Expect = 5e-24 Identities = 60/105 (57%), Positives = 74/105 (70%), Gaps = 3/105 (2%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNS 500 EHAAL+PR+LGGR II KSFARIHETNLKKQG++PLTFAN ADYD + D +S GL Sbjct: 656 EHAALQPRYLGGRIIISKSFARIHETNLKKQGIVPLTFANEADYDLFEACDDVSTRGLLD 715 Query: 499 L--APGK-PVDCEIKHKDGSTDRIKLNHSLNDQQINWFKAGSALN 374 + + GK V+ IK +DGS +K H+L+ Q + AGSALN Sbjct: 716 VLKSGGKGQVELVIKKRDGSEKVVKTKHTLSHDQCGFVLAGSALN 760 >UniRef50_Q4PB22 Cluster: Putative uncharacterized protein; n=5; Fungi/Metazoa group|Rep: Putative uncharacterized protein - Ustilago maydis (Smut fungus) Length = 1041 Score = 84.2 bits (199), Expect = 3e-15 Identities = 50/120 (41%), Positives = 69/120 (57%), Gaps = 11/120 (9%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNS 500 EHAAL+PR G I+ +S ARI ETNL+KQG+L L F N DY KI D + + L Sbjct: 800 EHAALQPRFYGCNLIVARSIARIAETNLRKQGVLTLLFENEDDYLKIGSGDLVETVNLTD 859 Query: 499 L-APGKPVDCEIKHK------DGSTDR----IKLNHSLNDQQINWFKAGSALNRMKEIAS 353 L PG + ++K K DG T + + HSL+ ++W +AGSALN ++E A+ Sbjct: 860 LIRPGGDLSTQVKLKVTKFEQDGKTVKETFELATKHSLSAAHLDWIRAGSALNLIREQAA 919 >UniRef50_Q74AD1 Cluster: Aconitate hydratase, putative; n=12; Bacteria|Rep: Aconitate hydratase, putative - Geobacter sulfurreducens Length = 645 Score = 81.4 bits (192), Expect = 2e-14 Identities = 49/108 (45%), Positives = 63/108 (58%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNS 500 EHAAL PR+LG RA IVKSFARIH+ NL G+LPLTF N ADYD +K D++ + Sbjct: 541 EHAALAPRYLGIRAKIVKSFARIHKANLVNFGILPLTFKNPADYDLLKQGDRLEFPDVRR 600 Query: 499 LAPGKPVDCEIKHKDGSTDRIKLNHSLNDQQINWFKAGSALNRMKEIA 356 L V EI + G + + L ++D+Q AG LN +K A Sbjct: 601 LVASGAV--EIPVRVGGKEIVTL-LDVSDRQRQELLAGGTLNYVKRSA 645 >UniRef50_Q5NTF8 Cluster: Aconitase; n=1; uncultured bacterium|Rep: Aconitase - uncultured bacterium Length = 369 Score = 81.4 bits (192), Expect = 2e-14 Identities = 43/106 (40%), Positives = 58/106 (54%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNS 500 EHAA+EPR+ GG I+ +SFARIHETNLKKQG+ + S Sbjct: 258 EHAAMEPRYRGGVVILARSFARIHETNLKKQGLCATYVCRTRIRTISSVNATPSACSGYR 317 Query: 499 LAPGKPVDCEIKHKDGSTDRIKLNHSLNDQQINWFKAGSALNRMKE 362 KPV C I G+T + H+ + +Q+ WFKAGSALN +++ Sbjct: 318 RCQKKPVRCVINKPYGTTIEFEALHTFSAEQVEWFKAGSALNVVRQ 363 >UniRef50_Q7NDZ5 Cluster: Aconitate hydratase; n=28; Bacteria|Rep: Aconitate hydratase - Gloeobacter violaceus Length = 645 Score = 72.1 bits (169), Expect = 1e-11 Identities = 34/58 (58%), Positives = 43/58 (74%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGL 506 EHAAL P +LG RA+IVKSFARIH NL G+LPLTFA+ AD+D + D++ L G+ Sbjct: 535 EHAALAPMYLGVRAVIVKSFARIHRANLINFGILPLTFADEADHDGVDQGDQLRLEGI 592 >UniRef50_O67656 Cluster: Aconitase; n=17; cellular organisms|Rep: Aconitase - Aquifex aeolicus Length = 659 Score = 70.5 bits (165), Expect = 3e-11 Identities = 45/106 (42%), Positives = 58/106 (54%), Gaps = 1/106 (0%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGL-N 503 EHAAL PR LG RA+I KSFARIH NL G++PL F N DYDK D+I + L Sbjct: 548 EHAALAPRFLGVRAVIAKSFARIHHANLVNFGVVPLEFKNKEDYDKFSLGDEIEIPNLIE 607 Query: 502 SLAPGKPVDCEIKHKDGSTDRIKLNHSLNDQQINWFKAGSALNRMK 365 L G+ D + +K + + I ++L Q AG LN +K Sbjct: 608 RLKKGE--DILVINKT-TGEEILCTYNLTPVQKEILIAGGRLNYIK 650 >UniRef50_Q9I3F5 Cluster: Aconitate hydratase 1; n=98; Bacteria|Rep: Aconitate hydratase 1 - Pseudomonas aeruginosa Length = 910 Score = 63.7 bits (148), Expect = 4e-09 Identities = 36/97 (37%), Positives = 55/97 (56%), Gaps = 4/97 (4%) Frame = -3 Query: 652 LGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDK--ISLLGL-NSLAPGKP 482 LG +A+I +SF RIH +NL G+LPL F N D +K K +++ GL L P P Sbjct: 807 LGVKAVIAESFERIHRSNLVGMGVLPLQFENGQDRKSLKLTGKEVLNIRGLGGELKPHMP 866 Query: 481 VDCEIKHKDGSTDRIKLNHSLND-QQINWFKAGSALN 374 + E+ +DGS D K+ ++ ++ +FKAG L+ Sbjct: 867 LSVEVTREDGSQDSFKVLCRIDTLNEVEYFKAGGILH 903 >UniRef50_Q0PQM5 Cluster: Aconitase A; n=1; Endoriftia persephone 'Hot96_1+Hot96_2'|Rep: Aconitase A - Endoriftia persephone 'Hot96_1+Hot96_2' Length = 103 Score = 62.1 bits (144), Expect = 1e-08 Identities = 29/49 (59%), Positives = 35/49 (71%) Frame = -3 Query: 661 PRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISL 515 PR LG RA++V FARIH NL G++ LTFAN ADYDKIK D +S+ Sbjct: 33 PRCLGVRAVVVSQFARIHVANLVNFGIVHLTFANEADYDKIKQGDTVSI 81 >UniRef50_Q0ADB7 Cluster: Aconitate hydratase 1; n=5; Bacteria|Rep: Aconitate hydratase 1 - Nitrosomonas eutropha (strain C71) Length = 947 Score = 58.8 bits (136), Expect = 1e-07 Identities = 32/102 (31%), Positives = 56/102 (54%), Gaps = 3/102 (2%) Frame = -3 Query: 673 AALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDK--IKPDDKISLLGLNS 500 AA P+ LG +A+I +S+ RIH +NL G+LPL F I+ D++ +LGL Sbjct: 837 AAKGPQLLGVKAVIAESYERIHRSNLIGMGVLPLQFKEGDSMASLGIQGDERFDILGLGD 896 Query: 499 LAPGKPVDCEIKHKDGSTDRIKLNHSLNDQ-QINWFKAGSAL 377 L P + + I +DGS ++L ++ ++++++ G L Sbjct: 897 LQPQQEITLVIHSQDGSRREVRLRSRIDTAIEVDYYRHGGIL 938 >UniRef50_A4FHT3 Cluster: Aconitate hydratase 1; n=2; Actinomycetales|Rep: Aconitate hydratase 1 - Saccharopolyspora erythraea (strain NRRL 23338) Length = 711 Score = 56.0 bits (129), Expect = 8e-07 Identities = 35/96 (36%), Positives = 55/96 (57%), Gaps = 4/96 (4%) Frame = -3 Query: 652 LGGRAIIVKSFARIHETNLKKQGMLPLTF--ANAADYDKIKPDDKISLLGLNSLAPG-KP 482 LG RA+I +SF RIH NL G+LPL F A ++ +D+++L GL+ L PG Sbjct: 601 LGVRAVIAESFERIHRGNLIGMGVLPLQFPPGRGARDCELTGEDELALTGLDRLEPGINA 660 Query: 481 VDCEIKHKDGSTDRIKLNHSLNDQ-QINWFKAGSAL 377 V I+ +DG+ D L+ L+ + +I++ + G L Sbjct: 661 VRLTIRRRDGTEDGFDLHLRLDTRHEIDYLRHGGTL 696 >UniRef50_Q5V0F1 Cluster: Aconitate hydratase; n=8; cellular organisms|Rep: Aconitate hydratase - Haloarcula marismortui (Halobacterium marismortui) Length = 677 Score = 50.8 bits (116), Expect = 3e-05 Identities = 25/56 (44%), Positives = 37/56 (66%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLL 512 EHAAL P +LG ++ +SFARIH+ NL G++PLT + Y+KI+ D I ++ Sbjct: 562 EHAALCPMYLGIETVLAQSFARIHKANLFNFGIVPLTI-DEETYEKIEEGDDIEVV 616 >UniRef50_A7CSQ0 Cluster: Aconitate hydratase 1; n=1; Opitutaceae bacterium TAV2|Rep: Aconitate hydratase 1 - Opitutaceae bacterium TAV2 Length = 965 Score = 46.8 bits (106), Expect = 5e-04 Identities = 25/96 (26%), Positives = 53/96 (55%), Gaps = 4/96 (4%) Frame = -3 Query: 652 LGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPD--DKISLLGLN-SLAPGKP 482 LG + ++ +SF RIH +NL G+LPL F + +K D + ++GL+ ++ P + Sbjct: 859 LGVKVVVAQSFERIHRSNLVGMGVLPLQFKDGTTAQTLKLDGSETYDVVGLDATIRPQQD 918 Query: 481 VDCEIKHKDGSTDRIKLNHSLNDQ-QINWFKAGSAL 377 + I KDG+ + ++ ++ ++++++ G L Sbjct: 919 LTLRITRKDGTQQNVAVSCRIDTPIEVDYYQHGGIL 954 >UniRef50_A1W553 Cluster: Aconitate hydratase 1 precursor; n=8; Proteobacteria|Rep: Aconitate hydratase 1 precursor - Acidovorax sp. (strain JS42) Length = 972 Score = 46.0 bits (104), Expect = 9e-04 Identities = 27/102 (26%), Positives = 52/102 (50%), Gaps = 3/102 (2%) Frame = -3 Query: 673 AALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDK--IKPDDKISLLGLNS 500 AA + LG +A++ +SF RIH +NL G+LPL + ++ D+ I ++ + Sbjct: 861 AAKGTQLLGIKAVVARSFERIHRSNLVGMGVLPLQLRGNDSWQSLGLQGDEVIDVIPDPA 920 Query: 499 LAPGKPVDCEIKHKDGSTDRIKLNHSLNDQ-QINWFKAGSAL 377 L P I+ DGS + + ++ ++++++AG L Sbjct: 921 LTPQSEARLVIRRADGSCQEVAVTLRIDTPIEVDYYRAGGIL 962 >UniRef50_Q0ZQ48 Cluster: FrbA; n=6; cellular organisms|Rep: FrbA - Streptomyces rubellomurinus Length = 886 Score = 45.2 bits (102), Expect = 0.001 Identities = 26/76 (34%), Positives = 39/76 (51%), Gaps = 2/76 (2%) Frame = -3 Query: 673 AALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDK--IKPDDKISLLGLNS 500 AA P LG RA++ KSF RIH +NL G++PL F D + + + ++GL+ Sbjct: 772 AAKGPALLGVRAVLAKSFERIHRSNLIGMGIVPLEFLPDQDAGTLGLTGHEALDVIGLDG 831 Query: 499 LAPGKPVDCEIKHKDG 452 L P V + +G Sbjct: 832 LVPRGTVTVRARSAEG 847 >UniRef50_Q5P0Q2 Cluster: Aconitase; n=4; Proteobacteria|Rep: Aconitase - Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)) Length = 905 Score = 43.6 bits (98), Expect = 0.005 Identities = 27/104 (25%), Positives = 55/104 (52%), Gaps = 4/104 (3%) Frame = -3 Query: 673 AALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKI--KPDDKISLLGLN- 503 AA + LG RA+I +SF RIH +NL G+LPL F ++ + D+ +LG++ Sbjct: 791 AAKGTQLLGVRAVIARSFERIHRSNLVGMGVLPLQFKGQDSWESLGFVGDETFDVLGIDA 850 Query: 502 SLAPGKPVDCEIKHKDGSTDRIKLNHSLNDQ-QINWFKAGSALN 374 +L P + + ++G + + ++ ++++++ G L+ Sbjct: 851 TLKPQQDLSLVAHRRNGERIEVPVLCRIDTPVEVDYYRHGGILS 894 >UniRef50_O08451 Cluster: Aconitate hydratase; n=21; Bacteria|Rep: Aconitate hydratase - Mycobacterium avium Length = 961 Score = 42.7 bits (96), Expect = 0.008 Identities = 29/79 (36%), Positives = 41/79 (51%), Gaps = 4/79 (5%) Frame = -3 Query: 673 AALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPD--DKISLLGLNS 500 AA R LG RA+I +SF RIH +NL G++PL F + + D + + G+ Sbjct: 846 AAKGTRLLGVRAVIAESFERIHRSNLIGMGVIPLQFPDGKSAKDLGLDGTEVFDITGIEE 905 Query: 499 LAPGK-PVDCEIK-HKDGS 449 L GK P +K K+GS Sbjct: 906 LNKGKTPKTVHVKASKNGS 924 >UniRef50_Q125M5 Cluster: Aconitate hydratase-like; n=8; Proteobacteria|Rep: Aconitate hydratase-like - Polaromonas sp. (strain JS666 / ATCC BAA-500) Length = 888 Score = 41.9 bits (94), Expect = 0.014 Identities = 29/91 (31%), Positives = 45/91 (49%), Gaps = 3/91 (3%) Frame = -3 Query: 673 AALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYD--KIKPDDKISL-LGLN 503 AA R LG RA++ SF RIH +NL G+LPL + +++P D++ + Sbjct: 759 AAKGQRLLGIRAVLAASFERIHRSNLIGMGILPLRLPPGVNPHTLQLQPGDQLEIDADPQ 818 Query: 502 SLAPGKPVDCEIKHKDGSTDRIKLNHSLNDQ 410 LAP V I+ +GST + ++ Q Sbjct: 819 HLAPRCSVAVRIRRLNGSTQALLATAAVETQ 849 >UniRef50_P21399 Cluster: Iron-responsive element-binding protein 1; n=116; cellular organisms|Rep: Iron-responsive element-binding protein 1 - Homo sapiens (Human) Length = 889 Score = 40.7 bits (91), Expect = 0.032 Identities = 29/104 (27%), Positives = 52/104 (50%), Gaps = 2/104 (1%) Frame = -3 Query: 673 AALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTF--ANAADYDKIKPDDKISLLGLNS 500 AA P LG +A++ +S+ RIH +NL G++PL + AD + ++ +++ + Sbjct: 783 AAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPEN 842 Query: 499 LAPGKPVDCEIKHKDGSTDRIKLNHSLNDQQINWFKAGSALNRM 368 L P V ++K G T + + D ++ +F G LN M Sbjct: 843 LKPQMKV--QVKLDTGKTFQAVMRFD-TDVELTYFLNGGILNYM 883 >UniRef50_Q42560 Cluster: Aconitate hydratase 1; n=35; cellular organisms|Rep: Aconitate hydratase 1 - Arabidopsis thaliana (Mouse-ear cress) Length = 898 Score = 40.7 bits (91), Expect = 0.032 Identities = 20/45 (44%), Positives = 27/45 (60%) Frame = -3 Query: 673 AALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKI 539 AA P LG +A+I KSF RIH +NL G++PL F D + + Sbjct: 788 AAKGPMLLGVKAVISKSFERIHRSNLVGMGIIPLCFKAGEDAETL 832 >UniRef50_A5WEQ7 Cluster: 2-methylisocitrate dehydratase, Fe/S-dependent; n=155; cellular organisms|Rep: 2-methylisocitrate dehydratase, Fe/S-dependent - Psychrobacter sp. PRwf-1 Length = 903 Score = 40.3 bits (90), Expect = 0.042 Identities = 29/110 (26%), Positives = 46/110 (41%), Gaps = 2/110 (1%) Frame = -3 Query: 673 AALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNSLA 494 AA R G ++ + F RIH NL G LP+ F + D ++ Sbjct: 791 AAKGVRLAGVECVVAEDFERIHRQNLVGMGALPVQFEAGTTRKTLNIDGTEVFDIEGEVS 850 Query: 493 PGKPVDCEIKHKDGSTDRIKLNHSLND-QQINWFKAGSALNRM-KEIASG 350 G + I KDGS D+ + L+ ++ +++G L R KE +G Sbjct: 851 AGGTMTLVIHRKDGSVDKAPVKCRLDTADEVKMYQSGGMLQRFAKEFLAG 900 >UniRef50_Q8NQ98 Cluster: Aconitate hydratase; n=10; Bacteria|Rep: Aconitate hydratase - Corynebacterium glutamicum (Brevibacterium flavum) Length = 939 Score = 40.3 bits (90), Expect = 0.042 Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 2/58 (3%) Frame = -3 Query: 652 LGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPD--DKISLLGLNSLAPGK 485 LG RA+I +SF RIH +NL G++PL F ++ + D + + GL +L G+ Sbjct: 830 LGIRAVITESFERIHRSNLIGMGVVPLQFPAGESHESLGLDGTETFDITGLTALNEGE 887 >UniRef50_Q7WB80 Cluster: Aconitate hydratase; n=3; Bordetella|Rep: Aconitate hydratase - Bordetella parapertussis Length = 894 Score = 37.5 bits (83), Expect = 0.30 Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 3/70 (4%) Frame = -3 Query: 652 LGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLL---GLNSLAPGKP 482 LG RA++ KS+ RIH NL G++P F + ++ D + L+ + G+P Sbjct: 790 LGVRAVLAKSYERIHRANLVGMGVIPFQFERGQGWRELGLDGSETFEFFDVLDGIRQGRP 849 Query: 481 VDCEIKHKDG 452 V DG Sbjct: 850 VRVAASRDDG 859 >UniRef50_Q098V5 Cluster: Aconitase; n=1; Stigmatella aurantiaca DW4/3-1|Rep: Aconitase - Stigmatella aurantiaca DW4/3-1 Length = 37 Score = 37.1 bits (82), Expect = 0.40 Identities = 14/30 (46%), Positives = 21/30 (70%) Frame = -3 Query: 463 HKDGSTDRIKLNHSLNDQQINWFKAGSALN 374 H DG+ + ++L HS + Q+ WF+ GSALN Sbjct: 3 HGDGTQETLQLEHSDSAPQLEWFRVGSALN 32 >UniRef50_A5C294 Cluster: Putative uncharacterized protein; n=1; Vitis vinifera|Rep: Putative uncharacterized protein - Vitis vinifera (Grape) Length = 885 Score = 37.1 bits (82), Expect = 0.40 Identities = 16/37 (43%), Positives = 23/37 (62%) Frame = -3 Query: 649 GGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKI 539 G +A+I KSF RIH +NL G++PL F D + + Sbjct: 781 GVKAVIAKSFERIHRSNLVGMGIIPLCFKPGQDAETL 817 >UniRef50_Q9RNH9 Cluster: Aconitase; n=3; Bacteria|Rep: Aconitase - Streptomyces coelicolor Length = 904 Score = 36.7 bits (81), Expect = 0.52 Identities = 19/57 (33%), Positives = 33/57 (57%), Gaps = 2/57 (3%) Frame = -3 Query: 652 LGGRAIIVKSFARIHETNLKKQGMLPLTF--ANAADYDKIKPDDKISLLGLNSLAPG 488 LG +A++ +S+ RIH +NL G+LPL F + A+ + ++ S+ G+ L G Sbjct: 801 LGVKAVVAESYERIHRSNLIGMGVLPLQFPEGHTAESLGLTGEETFSVSGVTELNEG 857 >UniRef50_Q9L1C2 Cluster: Putative phosphatase; n=1; Streptomyces coelicolor|Rep: Putative phosphatase - Streptomyces coelicolor Length = 216 Score = 36.7 bits (81), Expect = 0.52 Identities = 20/58 (34%), Positives = 29/58 (50%) Frame = -3 Query: 640 AIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNSLAPGKPVDCEI 467 A++ + R+ E L G+LP T A D + KPD + LLG +L P DC + Sbjct: 103 AVVTSATRRLAEARLDAVGILPKTLVAADDITRGKPDPEPYLLGARALGV-DPADCVV 159 >UniRef50_Q4T087 Cluster: Chromosome undetermined SCAF11289, whole genome shotgun sequence; n=3; Euteleostomi|Rep: Chromosome undetermined SCAF11289, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer) Length = 894 Score = 36.3 bits (80), Expect = 0.69 Identities = 23/63 (36%), Positives = 35/63 (55%), Gaps = 2/63 (3%) Frame = -3 Query: 673 AALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTF--ANAADYDKIKPDDKISLLGLNS 500 AA P LG +A+I +S+ RIH +NL G++PL F + A + ++ S+L Sbjct: 755 AAKGPFLLGIKAVIAESYERIHRSNLVGMGVVPLEFLPGDTAQSLGLTGRERYSVLLPQQ 814 Query: 499 LAP 491 LAP Sbjct: 815 LAP 817 >UniRef50_Q6NH63 Cluster: Aconitate hydratase; n=32; cellular organisms|Rep: Aconitate hydratase - Corynebacterium diphtheriae Length = 934 Score = 35.9 bits (79), Expect = 0.91 Identities = 22/78 (28%), Positives = 38/78 (48%), Gaps = 3/78 (3%) Frame = -3 Query: 652 LGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPD--DKISLLGLNSLAPG-KP 482 LG +A+I +SF RIH +NL G++PL F + + D + + G+ L G P Sbjct: 827 LGVKAVITESFERIHRSNLIGMGVIPLQFPAGESHASLGLDGTETFDIEGIEELNNGVTP 886 Query: 481 VDCEIKHKDGSTDRIKLN 428 + S D+++ + Sbjct: 887 KTVHVTATKESGDQVEFD 904 >UniRef50_UPI00006CB1D5 Cluster: hypothetical protein TTHERM_00300660; n=1; Tetrahymena thermophila SB210|Rep: hypothetical protein TTHERM_00300660 - Tetrahymena thermophila SB210 Length = 1262 Score = 35.5 bits (78), Expect = 1.2 Identities = 26/94 (27%), Positives = 41/94 (43%) Frame = -3 Query: 631 VKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNSLAPGKPVDCEIKHKDG 452 V SF +I N +KQ LP + + ++ +IK +K +N + + Sbjct: 435 VTSFIQIQNIN-QKQENLPTSTKSITNFKQIKNIEKPIQKQINQITNNYTHQNSMIFSKH 493 Query: 451 STDRIKLNHSLNDQQINWFKAGSALNRMKEIASG 350 S + N LN Q++ K G N+MKEI G Sbjct: 494 SLQQENNNDELNFTQLSQLKGGERKNKMKEIIKG 527 >UniRef50_Q59938 Cluster: Aconitate hydratase; n=356; cellular organisms|Rep: Aconitate hydratase - Streptococcus mutans Length = 888 Score = 35.1 bits (77), Expect = 1.6 Identities = 14/39 (35%), Positives = 24/39 (61%) Frame = -3 Query: 652 LGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIK 536 LG + ++ +SF RIH +NL G+LPL F + + ++ Sbjct: 784 LGVKVVLAESFERIHRSNLVMMGILPLQFLDGQTAESLQ 822 >UniRef50_Q4WBR0 Cluster: Aconitase family protein; n=7; Pezizomycotina|Rep: Aconitase family protein - Aspergillus fumigatus (Sartorya fumigata) Length = 811 Score = 33.5 bits (73), Expect = 4.9 Identities = 17/55 (30%), Positives = 28/55 (50%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISL 515 E A + G + +I KSFA I + N+ G+L +T N + Y K ++S+ Sbjct: 688 EQAVMALLGCGIKCVIAKSFAFIFQRNMPNLGLLGITMPNESFYAAAKDGSEVSI 742 >UniRef50_Q5JE83 Cluster: Hypothetical membrane protein; n=1; Thermococcus kodakarensis KOD1|Rep: Hypothetical membrane protein - Pyrococcus kodakaraensis (Thermococcus kodakaraensis) Length = 158 Score = 33.5 bits (73), Expect = 4.9 Identities = 15/43 (34%), Positives = 24/43 (55%) Frame = +3 Query: 342 FHFPEAISFILLSAEPALNQLICWSFNEWLSLMRSVLPSLCLI 470 FHF + +F+LL P L +I + EW L+ +PSL ++ Sbjct: 44 FHFSPSATFVLLVTAPFLISIILGLWKEWGELVAFGIPSLAVV 86 >UniRef50_A3Q2Y8 Cluster: Von Willebrand factor, type A; n=5; Mycobacterium|Rep: Von Willebrand factor, type A - Mycobacterium sp. (strain JLS) Length = 570 Score = 33.1 bits (72), Expect = 6.4 Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 1/66 (1%) Frame = -3 Query: 676 HAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPD-DKISLLGLNS 500 H ALE G A + S ET++ ++ +FA+AAD ++ P D++ + L Sbjct: 502 HKALEELRTEGVACLCLSIGAATETDVLERVFGSASFASAADLSELSPQMDELFMSALAE 561 Query: 499 LAPGKP 482 LA KP Sbjct: 562 LAAPKP 567 >UniRef50_A3PL44 Cluster: Aminoglycoside phosphotransferase precursor; n=3; Rhodobacter sphaeroides|Rep: Aminoglycoside phosphotransferase precursor - Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9) Length = 345 Score = 33.1 bits (72), Expect = 6.4 Identities = 17/48 (35%), Positives = 28/48 (58%) Frame = -3 Query: 589 QGMLPLTFANAADYDKIKPDDKISLLGLNSLAPGKPVDCEIKHKDGST 446 QG L ANAA+ + ++LL L ++APG PV I+ ++G++ Sbjct: 55 QGAFVLKIANAAEPRGVTECQTLALLHLEAVAPGLPVPRVIRTREGAS 102 >UniRef50_Q0G320 Cluster: Isopropylmalate isomerase small subunit; n=1; Fulvimarina pelagi HTCC2506|Rep: Isopropylmalate isomerase small subunit - Fulvimarina pelagi HTCC2506 Length = 211 Score = 32.7 bits (71), Expect = 8.5 Identities = 16/39 (41%), Positives = 22/39 (56%) Frame = -3 Query: 679 EHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFA 563 EH+ G RA+I S+A IH N K G+LP+T + Sbjct: 89 EHSPWAMYDFGIRAVIAISYADIHYNNCFKNGILPVTLS 127 >UniRef50_A4SVJ3 Cluster: MotA/TolQ/ExbB proton channel; n=1; Polynucleobacter sp. QLW-P1DMWA-1|Rep: MotA/TolQ/ExbB proton channel - Polynucleobacter sp. QLW-P1DMWA-1 Length = 212 Score = 32.7 bits (71), Expect = 8.5 Identities = 25/100 (25%), Positives = 42/100 (42%), Gaps = 2/100 (2%) Frame = -3 Query: 646 GRAIIVKSFARIHETNLKKQGMLPLTFANAADYDKIKPDDKISLLGLNSLAPGKPV-DCE 470 G AI+++ + + ++ +G L LTF K + + L L+P P+ C Sbjct: 22 GLAIVIERSWYLRQIHIFPKGSLELTFGMCNQIANQKNVSEAQVTELAQLSPATPLFACV 81 Query: 469 IKHK-DGSTDRIKLNHSLNDQQINWFKAGSALNRMKEIAS 353 +K K GS+ + L Q W K L + IA+ Sbjct: 82 LKEKLSGSSAAVALEELQALAQATWLKLDRYLGALATIAT 121 >UniRef50_Q0URF6 Cluster: Predicted protein; n=1; Phaeosphaeria nodorum|Rep: Predicted protein - Phaeosphaeria nodorum (Septoria nodorum) Length = 511 Score = 32.7 bits (71), Expect = 8.5 Identities = 13/41 (31%), Positives = 24/41 (58%), Gaps = 1/41 (2%) Frame = +3 Query: 141 LNYTMTRLHWLHLIPLK-RLQYSRVNTISHIKATRNAPKQY 260 L + T L W+ P++ +L+++ V +HI + APK+Y Sbjct: 425 LTWNATCLEWIEFTPVELQLEHNTVELFAHIAVKKGAPKEY 465 Database: uniref50 Posted date: Oct 5, 2007 11:19 AM Number of letters in database: 575,637,011 Number of sequences in database: 1,657,284 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.279 0.0580 0.190 Matrix: BLOSUM62 Gap Penalties: Existence: 9, Extension: 2 Number of Hits to DB: 543,340,756 Number of Sequences: 1657284 Number of extensions: 9447243 Number of successful extensions: 24482 Number of sequences better than 10.0: 46 Number of HSP's better than 10.0 without gapping: 23924 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 24471 length of database: 575,637,011 effective HSP length: 98 effective length of database: 413,223,179 effective search space used: 52892566912 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 37 (14.9 bits) X3: 62 (25.0 bits) S1: 41 (21.7 bits)
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