Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fe100P04_F_G04
(651 letters)
Database: human
237,096 sequences; 76,859,062 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein. 184 2e-46
M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein. 184 2e-46
M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein. 184 2e-46
CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein. 184 2e-46
BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal ... 184 2e-46
BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal ... 184 2e-46
BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein. 184 2e-46
BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic pepti... 159 8e-39
AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4 pro... 159 1e-38
AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor prot... 159 1e-38
AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein. 159 1e-38
BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein. 143 4e-34
AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3 pro... 143 4e-34
M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein. 141 2e-33
J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein. 141 2e-33
BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein. 141 2e-33
BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein. 141 2e-33
BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein. 141 2e-33
AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein. 141 2e-33
AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternativ... 141 2e-33
M26901-1|AAA60364.1| 403|Homo sapiens renin protein. 138 2e-32
M10152-1|AAD03461.1| 406|Homo sapiens renin protein. 138 2e-32
L00073-1|AAA60363.1| 406|Homo sapiens renin protein. 138 2e-32
CR536498-1|CAG38737.1| 406|Homo sapiens REN protein. 138 2e-32
BC047752-1|AAH47752.1| 406|Homo sapiens renin protein. 138 2e-32
BC033474-1|AAH33474.1| 406|Homo sapiens renin protein. 138 2e-32
AY436324-1|AAR03502.1| 403|Homo sapiens renin protein. 138 2e-32
AL592146-1|CAI16594.1| 406|Homo sapiens renin protein. 138 2e-32
AL592114-1|CAH71224.1| 406|Homo sapiens renin protein. 138 2e-32
U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein. 135 1e-31
M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein. 135 1e-31
M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein. 135 1e-31
J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein. 135 1e-31
BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinog... 135 1e-31
AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinog... 135 1e-31
J00287-1|AAA98529.1| 388|Homo sapiens PEP protein. 130 6e-30
BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I (... 130 6e-30
M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein. 128 2e-29
X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mR... 85 3e-16
BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein. 60 7e-09
BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving ... 56 1e-07
AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein. 56 1e-07
AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein. 56 1e-07
AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic ... 56 1e-07
AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1 pro... 56 1e-07
AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein. 56 1e-07
AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein. 56 1e-07
AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein. 56 1e-07
AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein. 56 1e-07
AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease ... 56 1e-07
AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein. 56 1e-07
AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens ... 53 1e-06
DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving ... 44 4e-04
BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving ... 44 4e-04
AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving ... 44 4e-04
AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic ... 44 4e-04
AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase prot... 44 4e-04
AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2 pro... 44 4e-04
AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein. 44 4e-04
AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving ... 44 4e-04
AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving ... 44 4e-04
AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein. 44 4e-04
AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving ... 42 0.001
BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving ... 42 0.002
AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving ... 42 0.002
AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving ... 42 0.002
AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving ... 39 0.013
AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinog... 39 0.018
AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving ... 37 0.072
AF141344-1|AAG49447.1| 119|Homo sapiens LYST-interacting protei... 32 1.5
AK055141-1|BAB70862.1| 260|Homo sapiens protein ( Homo sapiens ... 32 2.0
BC030606-1|AAH30606.2| 514|Homo sapiens coiled-coil domain cont... 31 4.7
BC035605-1|AAH35605.1| 578|Homo sapiens schlafen family member ... 25 6.0
AK001122-1|BAA91512.1| 578|Homo sapiens protein ( Homo sapiens ... 25 6.0
BC133035-1|AAI33036.1| 129|Homo sapiens keratin associated prot... 30 6.2
BC130399-1|AAI30400.1| 129|Homo sapiens keratin associated prot... 30 6.2
AB126075-1|BAD20202.1| 129|Homo sapiens keratin associated prot... 30 6.2
AK096194-1|BAC04723.1| 138|Homo sapiens protein ( Homo sapiens ... 30 8.2
AB126079-1|BAD20206.1| 202|Homo sapiens keratin associated prot... 30 8.2
>X05344-1|CAA28955.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 184 bits (448), Expect = 2e-46
Identities = 99/185 (53%), Positives = 117/185 (63%), Gaps = 22/185 (11%)
Frame = +3
Query: 162 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 308
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 635
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 636 VAAKF 650
+AAKF
Sbjct: 191 IAAKF 195
>M63138-1|AAA51922.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 184 bits (448), Expect = 2e-46
Identities = 99/185 (53%), Positives = 117/185 (63%), Gaps = 22/185 (11%)
Frame = +3
Query: 162 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 308
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 635
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 636 VAAKF 650
+AAKF
Sbjct: 191 IAAKF 195
>M11233-1|AAB59529.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 184 bits (448), Expect = 2e-46
Identities = 99/185 (53%), Positives = 117/185 (63%), Gaps = 22/185 (11%)
Frame = +3
Query: 162 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 308
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 635
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 636 VAAKF 650
+AAKF
Sbjct: 191 IAAKF 195
>CR456947-1|CAG33228.1| 412|Homo sapiens CTSD protein.
Length = 412
Score = 184 bits (448), Expect = 2e-46
Identities = 99/185 (53%), Positives = 117/185 (63%), Gaps = 22/185 (11%)
Frame = +3
Query: 162 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 308
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 635
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 636 VAAKF 650
+AAKF
Sbjct: 191 IAAKF 195
>BT020155-1|AAV38957.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 184 bits (448), Expect = 2e-46
Identities = 99/185 (53%), Positives = 117/185 (63%), Gaps = 22/185 (11%)
Frame = +3
Query: 162 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 308
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 635
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 636 VAAKF 650
+AAKF
Sbjct: 191 IAAKF 195
>BT006910-1|AAP35556.1| 412|Homo sapiens cathepsin D (lysosomal
aspartyl protease) protein.
Length = 412
Score = 184 bits (448), Expect = 2e-46
Identities = 99/185 (53%), Positives = 117/185 (63%), Gaps = 22/185 (11%)
Frame = +3
Query: 162 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 308
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 635
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 636 VAAKF 650
+AAKF
Sbjct: 191 IAAKF 195
>BC016320-1|AAH16320.1| 412|Homo sapiens cathepsin D protein.
Length = 412
Score = 184 bits (448), Expect = 2e-46
Identities = 99/185 (53%), Positives = 117/185 (63%), Gaps = 22/185 (11%)
Frame = +3
Query: 162 LALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVT-----------GPSPEP 308
L L+A+ AL R+PLH+ + R EVG +E L K V+ GP PE
Sbjct: 11 LCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEV 70
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L NY+DAQYYG I IGTPPQ F VVFDTGSSNLWVPS C +IAC +H+KY+S KS T
Sbjct: 71 LKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSST 130
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTV-----------GGLKVRRQTFAEAVSEPGLAF 635
YV NGT F I YGSGSLSG+LS D V+V GG+KV RQ F EA +PG+ F
Sbjct: 131 YVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITF 190
Query: 636 VAAKF 650
+AAKF
Sbjct: 191 IAAKF 195
>BC017842-1|AAH17842.1| 420|Homo sapiens napsin A aspartic
peptidase protein.
Length = 420
Score = 159 bits (386), Expect = 8e-39
Identities = 77/165 (46%), Positives = 105/165 (63%), Gaps = 5/165 (3%)
Frame = +3
Query: 171 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 335
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRTLNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 336 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 515
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 516 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
IQYG+G + G LS D +T+GG+K F EA+ EP L F A F
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHF 183
>AF200345-1|AAF17081.1| 420|Homo sapiens aspartyl protease 4
protein.
Length = 420
Score = 159 bits (385), Expect = 1e-38
Identities = 77/165 (46%), Positives = 105/165 (63%), Gaps = 5/165 (3%)
Frame = +3
Query: 171 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 335
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 336 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 515
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 516 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
IQYG+G + G LS D +T+GG+K F EA+ EP L F A F
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHF 183
>AF098484-1|AAD13215.1| 420|Homo sapiens napsin 1 precursor
protein.
Length = 420
Score = 159 bits (385), Expect = 1e-38
Identities = 77/165 (46%), Positives = 105/165 (63%), Gaps = 5/165 (3%)
Frame = +3
Query: 171 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 335
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 336 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 515
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 516 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
IQYG+G + G LS D +T+GG+K F EA+ EP L F A F
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHF 183
>AF090386-1|AAD04917.1| 420|Homo sapiens napsin A protein.
Length = 420
Score = 159 bits (385), Expect = 1e-38
Identities = 77/165 (46%), Positives = 105/165 (63%), Gaps = 5/165 (3%)
Frame = +3
Query: 171 IASSVMALYRVPLHRMKTARTHFHEVG---TELELLRLKYDVTGPSP--EPLSNYLDAQY 335
+ S L R+PLHR++ R + + EL +L G P PLSNY D QY
Sbjct: 19 VEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQY 78
Query: 336 YGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFA 515
+G I +GTPPQ+F V FDTGSSNLWVPS++CH+ ++ C LH+++D + S ++ ANGT+FA
Sbjct: 79 FGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFA 138
Query: 516 IQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
IQYG+G + G LS D +T+GG+K F EA+ EP L F A F
Sbjct: 139 IQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHF 183
>BC111705-1|AAI11706.1| 464|Homo sapiens NAPSB protein protein.
Length = 464
Score = 143 bits (347), Expect = 4e-34
Identities = 68/157 (43%), Positives = 99/157 (63%), Gaps = 5/157 (3%)
Frame = +3
Query: 192 LYRVPLHRMKTARTHFHEV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 356
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 22 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 81
Query: 357 TPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGS 536
TPPQ+F V FDTGSSNLWVPS++CH+ ++ C H++++ S ++ +GT+FAIQYG+G
Sbjct: 82 TPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGR 141
Query: 537 LSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAK 647
+ G LS D +T+GG+K F EA+ E L F ++
Sbjct: 142 VDGILSEDKLTIGGIKGASVIFGEALWESSLVFTVSR 178
>AF200344-1|AAF17080.1| 450|Homo sapiens aspartyl protease 3
protein.
Length = 450
Score = 143 bits (347), Expect = 4e-34
Identities = 68/157 (43%), Positives = 99/157 (63%), Gaps = 5/157 (3%)
Frame = +3
Query: 192 LYRVPLHRMKTARTHFHEV---GTELELLRLKYDVTGPSPE--PLSNYLDAQYYGVISIG 356
L R+PL ++ R + + G EL +L G P PLS +LDAQY+G I +G
Sbjct: 26 LIRIPLRQVHPGRRTLNLLRGWGKPAELPKLGAPSPGDKPASVPLSKFLDAQYFGEIGLG 85
Query: 357 TPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGS 536
TPPQ+F V FDTGSSNLWVPS++CH+ ++ C H++++ S ++ +GT+FAIQYG+G
Sbjct: 86 TPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWFHHRFNPNASSSFKPSGTKFAIQYGTGR 145
Query: 537 LSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAK 647
+ G LS D +T+GG+K F EA+ E L F ++
Sbjct: 146 VDGILSEDKLTIGGIKGASVIFGEALWESSLVFTVSR 182
>M84424-1|AAA52300.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 141 bits (341), Expect = 2e-33
Identities = 78/176 (44%), Positives = 106/176 (60%), Gaps = 10/176 (5%)
Frame = +3
Query: 153 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 302
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 303 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 482
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 483 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+F
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEF 181
>J05036-1|AAA52130.1| 396|Homo sapiens CTSE protein.
Length = 396
Score = 141 bits (341), Expect = 2e-33
Identities = 78/176 (44%), Positives = 106/176 (60%), Gaps = 10/176 (5%)
Frame = +3
Query: 153 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 302
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 303 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 482
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 483 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+F
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEF 181
>BX571818-5|CAH73265.1| 363|Homo sapiens cathepsin E protein.
Length = 363
Score = 141 bits (341), Expect = 2e-33
Identities = 78/176 (44%), Positives = 106/176 (60%), Gaps = 10/176 (5%)
Frame = +3
Query: 153 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 302
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 303 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 482
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 483 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+F
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEF 181
>BX571818-4|CAH73264.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 141 bits (341), Expect = 2e-33
Identities = 78/176 (44%), Positives = 106/176 (60%), Gaps = 10/176 (5%)
Frame = +3
Query: 153 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 302
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 303 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 482
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 483 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+F
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEF 181
>BC042537-1|AAH42537.1| 396|Homo sapiens cathepsin E protein.
Length = 396
Score = 141 bits (341), Expect = 2e-33
Identities = 78/176 (44%), Positives = 106/176 (60%), Gaps = 10/176 (5%)
Frame = +3
Query: 153 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 302
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 303 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 482
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 483 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+F
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEF 181
>AJ250717-1|CAB82850.1| 396|Homo sapiens procathepsin E protein.
Length = 396
Score = 141 bits (341), Expect = 2e-33
Identities = 78/176 (44%), Positives = 106/176 (60%), Gaps = 10/176 (5%)
Frame = +3
Query: 153 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 302
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 303 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 482
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 483 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+F
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEF 181
>AJ250716-1|CAB82849.1| 363|Homo sapiens cathepsin E, alternative
protein.
Length = 363
Score = 141 bits (341), Expect = 2e-33
Identities = 78/176 (44%), Positives = 106/176 (60%), Gaps = 10/176 (5%)
Frame = +3
Query: 153 LFFLALIASSVMALYRVPLHRMKT------ARTHFHEVGTELELLRLKY----DVTGPSP 302
L L + + +L+RVPL R + AR+ E L +++ + +
Sbjct: 8 LLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAK 67
Query: 303 EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKS 482
EPL NYLD +Y+G ISIG+PPQ+F V+FDTGSSNLWVPS C T+ AC H+++ +S
Sbjct: 68 EPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYC--TSPACKTHSRFQPSQS 125
Query: 483 KTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
TY G F+IQYG+GSLSG + D V+V GL V Q F E+V+EPG FV A+F
Sbjct: 126 STYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEF 181
>M26901-1|AAA60364.1| 403|Homo sapiens renin protein.
Length = 403
Score = 138 bits (334), Expect = 2e-32
Identities = 62/114 (54%), Positives = 80/114 (70%)
Frame = +3
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+F
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAQF 190
>M10152-1|AAD03461.1| 406|Homo sapiens renin protein.
Length = 406
Score = 138 bits (334), Expect = 2e-32
Identities = 62/114 (54%), Positives = 80/114 (70%)
Frame = +3
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+F
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEF 190
>L00073-1|AAA60363.1| 406|Homo sapiens renin protein.
Length = 406
Score = 138 bits (334), Expect = 2e-32
Identities = 62/114 (54%), Positives = 80/114 (70%)
Frame = +3
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+F
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEF 190
>CR536498-1|CAG38737.1| 406|Homo sapiens REN protein.
Length = 406
Score = 138 bits (334), Expect = 2e-32
Identities = 62/114 (54%), Positives = 80/114 (70%)
Frame = +3
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+F
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEF 190
>BC047752-1|AAH47752.1| 406|Homo sapiens renin protein.
Length = 406
Score = 138 bits (334), Expect = 2e-32
Identities = 62/114 (54%), Positives = 80/114 (70%)
Frame = +3
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+F
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEF 190
>BC033474-1|AAH33474.1| 406|Homo sapiens renin protein.
Length = 406
Score = 138 bits (334), Expect = 2e-32
Identities = 62/114 (54%), Positives = 80/114 (70%)
Frame = +3
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+F
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEF 190
>AY436324-1|AAR03502.1| 403|Homo sapiens renin protein.
Length = 403
Score = 138 bits (334), Expect = 2e-32
Identities = 62/114 (54%), Positives = 80/114 (70%)
Frame = +3
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+F
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEF 190
>AL592146-1|CAI16594.1| 406|Homo sapiens renin protein.
Length = 406
Score = 138 bits (334), Expect = 2e-32
Identities = 62/114 (54%), Positives = 80/114 (70%)
Frame = +3
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+F
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEF 190
>AL592114-1|CAH71224.1| 406|Homo sapiens renin protein.
Length = 406
Score = 138 bits (334), Expect = 2e-32
Identities = 62/114 (54%), Positives = 80/114 (70%)
Frame = +3
Query: 309 LSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKT 488
L+NY+D QYYG I IGTPPQ+FKVVFDTGSSN+WVPS KC AC+ H +D+ S +
Sbjct: 78 LTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSS 137
Query: 489 YVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
Y NGT+ ++Y +G++SGFLS D +TVGG+ V Q F E P L F+ A+F
Sbjct: 138 YKHNGTELTLRYSTGTVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEF 190
>U75272-1|AAB18273.1| 388|Homo sapiens gastricsin protein.
Length = 388
Score = 135 bits (326), Expect = 1e-31
Identities = 75/163 (46%), Positives = 101/163 (61%), Gaps = 9/163 (5%)
Frame = +3
Query: 189 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 341
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 342 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 521
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 522 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
YGSGSL+GF D +TV ++V Q F + +EPG FV A+F
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQF 176
>M23077-1|AAA60063.1| 388|Homo sapiens pepsinogen C protein.
Length = 388
Score = 135 bits (326), Expect = 1e-31
Identities = 75/163 (46%), Positives = 101/163 (61%), Gaps = 9/163 (5%)
Frame = +3
Query: 189 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 341
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 342 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 521
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 522 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
YGSGSL+GF D +TV ++V Q F + +EPG FV A+F
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQF 176
>M18667-1|AAA60062.1| 385|Homo sapiens pepsinogen protein.
Length = 385
Score = 135 bits (326), Expect = 1e-31
Identities = 75/163 (46%), Positives = 101/163 (61%), Gaps = 9/163 (5%)
Frame = +3
Query: 189 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 341
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 14 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 72
Query: 342 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 521
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 73 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 130
Query: 522 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
YGSGSL+GF D +TV ++V Q F + +EPG FV A+F
Sbjct: 131 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQF 173
>J04443-1|AAA60074.1| 388|Homo sapiens pepsinogen protein.
Length = 388
Score = 135 bits (326), Expect = 1e-31
Identities = 75/163 (46%), Positives = 101/163 (61%), Gaps = 9/163 (5%)
Frame = +3
Query: 189 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 341
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 342 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 521
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 522 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
YGSGSL+GF D +TV ++V Q F + +EPG FV A+F
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQF 176
>BC073740-1|AAH73740.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 135 bits (326), Expect = 1e-31
Identities = 75/163 (46%), Positives = 101/163 (61%), Gaps = 9/163 (5%)
Frame = +3
Query: 189 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 341
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 342 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 521
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 522 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
YGSGSL+GF D +TV ++V Q F + +EPG FV A+F
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQF 176
>AL365205-1|CAI13181.1| 388|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 388
Score = 135 bits (326), Expect = 1e-31
Identities = 75/163 (46%), Positives = 101/163 (61%), Gaps = 9/163 (5%)
Frame = +3
Query: 189 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 341
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 342 VISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQ 521
ISIGTPPQ+F V+FDTGSSNLWVPS C + AC H++++ +S TY NG F++Q
Sbjct: 76 EISIGTPPQNFLVLFDTGSSNLWVPSVYCQ--SQACTSHSRFNPSESSTYSTNGQTFSLQ 133
Query: 522 YGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
YGSGSL+GF D +TV ++V Q F + +EPG FV A+F
Sbjct: 134 YGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQF 176
>J00287-1|AAA98529.1| 388|Homo sapiens PEP protein.
Length = 388
Score = 130 bits (313), Expect = 6e-30
Identities = 74/178 (41%), Positives = 98/178 (55%), Gaps = 12/178 (6%)
Frame = +3
Query: 153 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 302
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
Query: 303 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 476
+PL NYLD +Y+G I IGTP Q F VVFDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 477 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
S TY + +I YG+GS++G L D V VGG+ Q F + +EPG A F
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPF 179
>BC029055-1|AAH29055.1| 388|Homo sapiens pepsinogen 5, group I
(pepsinogen A) protein.
Length = 388
Score = 130 bits (313), Expect = 6e-30
Identities = 74/178 (41%), Positives = 98/178 (55%), Gaps = 12/178 (6%)
Frame = +3
Query: 153 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 302
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
Query: 303 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 476
+PL NYLD +Y+G I IGTP Q F VVFDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 477 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
S TY + +I YG+GS++G L D V VGG+ Q F + +EPG A F
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPF 179
>M26032-1|AAA60061.1| 388|Homo sapiens pepsinogen A protein.
Length = 388
Score = 128 bits (309), Expect = 2e-29
Identities = 73/178 (41%), Positives = 98/178 (55%), Gaps = 12/178 (6%)
Frame = +3
Query: 153 LFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRL-------KYDVTGPSP--- 302
L L L+A S +Y+VPL R K+ R E G + L+ KY +P
Sbjct: 4 LLLLGLVALSECIMYKVPLIRKKSFRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLV 63
Query: 303 --EPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSR 476
+PL NYLD +Y+G I IGTP Q F V+FDTGSSNLWVPS C +++AC HN+++
Sbjct: 64 DEQPLENYLDMEYFGTIGIGTPAQDFTVLFDTGSSNLWVPSVYC--SSLACTNHNRFNPE 121
Query: 477 KSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKF 650
S TY + +I YG+GS++G L D V VGG+ Q F + +EPG A F
Sbjct: 122 DSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPF 179
>X00063-1|CAA24937.1| 300|Homo sapiens protein ( Human kidney mRNA
fragment for renin (aa 105-401). ).
Length = 300
Score = 84.6 bits (200), Expect = 3e-16
Identities = 38/84 (45%), Positives = 53/84 (63%)
Frame = +3
Query: 399 SNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGG 578
SN+WVPS KC AC+ H +D+ S +Y NGT+ ++Y +G++SGFLS D +TVGG
Sbjct: 1 SNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGG 60
Query: 579 LKVRRQTFAEAVSEPGLAFVAAKF 650
+ V Q F E P L F+ A+F
Sbjct: 61 ITV-TQMFGEVTEMPALPFMLAEF 83
>BC042578-1|AAH42578.1| 104|Homo sapiens PGC protein protein.
Length = 104
Score = 60.1 bits (139), Expect = 7e-09
Identities = 38/82 (46%), Positives = 49/82 (59%), Gaps = 9/82 (10%)
Frame = +3
Query: 189 ALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQYYG 341
A+ +VPL + K+ R E G E LR KYD + EP++ Y+DA Y+G
Sbjct: 17 AVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAAYFG 75
Query: 342 VISIGTPPQSFKVVFDTGSSNL 407
ISIGTPPQ+F V+FDTGSS L
Sbjct: 76 EISIGTPPQNFLVLFDTGSSPL 97
>BC014453-1|AAH14453.1| 518|Homo sapiens beta-site APP-cleaving
enzyme 2 protein.
Length = 518
Score = 55.6 bits (128), Expect = 1e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 513 AIQYGSGSLSGFLSTDDVTV 572
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AY358927-1|AAQ89286.1| 518|Homo sapiens BACE2 protein.
Length = 518
Score = 55.6 bits (128), Expect = 1e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 513 AIQYGSGSLSGFLSTDDVTV 572
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF212252-1|AAG41783.1| 439|Homo sapiens CDA13 protein.
Length = 439
Score = 55.6 bits (128), Expect = 1e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 13 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 66
Query: 513 AIQYGSGSLSGFLSTDDVTV 572
++Y GS +GF+ D VT+
Sbjct: 67 TVKYTQGSWTGFVGEDLVTI 86
>AF204944-1|AAF26368.1| 518|Homo sapiens transmembrane aspartic
proteinase Asp 1 protein.
Length = 518
Score = 55.6 bits (128), Expect = 1e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 513 AIQYGSGSLSGFLSTDDVTV 572
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF200342-1|AAF17078.1| 518|Homo sapiens aspartyl protease 1
protein.
Length = 518
Score = 55.6 bits (128), Expect = 1e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 513 AIQYGSGSLSGFLSTDDVTV 572
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF200192-1|AAF13714.1| 518|Homo sapiens memapsin 1 protein.
Length = 518
Score = 55.6 bits (128), Expect = 1e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 513 AIQYGSGSLSGFLSTDDVTV 572
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF188277-1|AAF35836.1| 396|Homo sapiens aspartyl protease protein.
Length = 396
Score = 55.6 bits (128), Expect = 1e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 513 AIQYGSGSLSGFLSTDDVTV 572
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF188276-1|AAF35835.1| 468|Homo sapiens aspartyl protease protein.
Length = 468
Score = 55.6 bits (128), Expect = 1e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 513 AIQYGSGSLSGFLSTDDVTV 572
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF178532-1|AAF29494.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 55.6 bits (128), Expect = 1e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 513 AIQYGSGSLSGFLSTDDVTV 572
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF117892-1|AAD45240.1| 518|Homo sapiens aspartic-like protease
protein.
Length = 518
Score = 55.6 bits (128), Expect = 1e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 513 AIQYGSGSLSGFLSTDDVTV 572
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AF050171-1|AAD45963.1| 518|Homo sapiens aspartyl protease protein.
Length = 518
Score = 55.6 bits (128), Expect = 1e-07
Identities = 29/80 (36%), Positives = 43/80 (53%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY + IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDV 145
Query: 513 AIQYGSGSLSGFLSTDDVTV 572
++Y GS +GF+ D VT+
Sbjct: 146 TVKYTQGSWTGFVGEDLVTI 165
>AK075539-1|BAC11682.1| 423|Homo sapiens protein ( Homo sapiens
cDNA PSEC0239 fis, clone OVARC1000363, highly similar to
Homo sapiens aspartyl protease mRNA. ).
Length = 423
Score = 52.8 bits (121), Expect = 1e-06
Identities = 27/74 (36%), Positives = 40/74 (54%)
Frame = +3
Query: 351 IGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGS 530
IGTPPQ +++ DTGSSN V Y + +D+ +S TY + G ++Y
Sbjct: 3 IGTPPQKLQILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDVTVKYTQ 56
Query: 531 GSLSGFLSTDDVTV 572
GS +GF+ D VT+
Sbjct: 57 GSWTGFVGEDLVTI 70
>DQ007053-1|AAY16982.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 44.4 bits (100), Expect = 4e-04
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 513 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV 638
+ Y G G L TD V++ G V + A++E F+
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI 171
>BC065492-1|AAH65492.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 44.4 bits (100), Expect = 4e-04
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 513 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV 638
+ Y G G L TD V++ G V + A++E F+
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI 171
>AF338816-1|AAK38374.1| 476|Homo sapiens beta-site APP cleaving
enzyme type B protein.
Length = 476
Score = 44.4 bits (100), Expect = 4e-04
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 513 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV 638
+ Y G G L TD V++ G V + A++E F+
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI 171
>AF204943-1|AAF26367.1| 501|Homo sapiens transmembrane aspartic
proteinase Asp 2 protein.
Length = 501
Score = 44.4 bits (100), Expect = 4e-04
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 513 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV 638
+ Y G G L TD V++ G V + A++E F+
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI 171
>AF201468-1|AAF18982.1| 501|Homo sapiens APP beta-secretase
protein.
Length = 501
Score = 44.4 bits (100), Expect = 4e-04
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 513 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV 638
+ Y G G L TD V++ G V + A++E F+
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI 171
>AF200343-1|AAF17079.1| 501|Homo sapiens aspartyl protease 2
protein.
Length = 501
Score = 44.4 bits (100), Expect = 4e-04
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 513 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV 638
+ Y G G L TD V++ G V + A++E F+
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI 171
>AF200193-1|AAF13715.1| 488|Homo sapiens memapsin 2 protein.
Length = 488
Score = 44.4 bits (100), Expect = 4e-04
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 62 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 115
Query: 513 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV 638
+ Y G G L TD V++ G V + A++E F+
Sbjct: 116 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI 158
>AF190725-1|AAF04142.1| 501|Homo sapiens beta-site APP cleaving
enzyme protein.
Length = 501
Score = 44.4 bits (100), Expect = 4e-04
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 513 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV 638
+ Y G G L TD V++ G V + A++E F+
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI 171
>AB050436-1|BAB40931.1| 476|Homo sapiens beta-site APP cleaving
enzyme I-476 protein.
Length = 476
Score = 44.4 bits (100), Expect = 4e-04
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 513 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV 638
+ Y G G L TD V++ G V + A++E F+
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI 171
>AB032975-1|BAA86463.2| 532|Homo sapiens KIAA1149 protein protein.
Length = 532
Score = 44.4 bits (100), Expect = 4e-04
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 106 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 159
Query: 513 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV 638
+ Y G G L TD V++ G V + A++E F+
Sbjct: 160 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI 202
>AB050438-1|BAB40933.1| 432|Homo sapiens beta-site APP cleaving
enzyme I-432 protein.
Length = 432
Score = 42.3 bits (95), Expect = 0.001
Identities = 27/94 (28%), Positives = 42/94 (44%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 513 AIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAV 614
+ Y G G L TD + G + + +V
Sbjct: 129 YVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASV 162
>BC036084-1|AAH36084.1| 501|Homo sapiens beta-site APP-cleaving
enzyme 1 protein.
Length = 501
Score = 41.9 bits (94), Expect = 0.002
Identities = 30/103 (29%), Positives = 47/103 (45%), Gaps = 1/103 (0%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLFSTYRDLRKGV 128
Query: 513 AIQYGSGSLSGFLSTDDVTV-GGLKVRRQTFAEAVSEPGLAFV 638
+ Y G G L TD V++ G V + A++E F+
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFI 171
>AF338817-1|AAK38375.1| 457|Homo sapiens beta-site APP cleaving
enzyme type C protein.
Length = 457
Score = 41.9 bits (94), Expect = 0.002
Identities = 25/76 (32%), Positives = 36/76 (47%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 513 AIQYGSGSLSGFLSTD 560
+ Y G G L TD
Sbjct: 129 YVPYTQGKWEGELGTD 144
>AB050437-1|BAB40932.1| 457|Homo sapiens beta-site APP cleaving
enzyme I-457 protein.
Length = 457
Score = 41.9 bits (94), Expect = 0.002
Identities = 25/76 (32%), Positives = 36/76 (47%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQF 512
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTYRDLRKGV 128
Query: 513 AIQYGSGSLSGFLSTD 560
+ Y G G L TD
Sbjct: 129 YVPYTQGKWEGELGTD 144
>AL163285-1|CAB90554.1| 415|Homo sapiens beta-site APP-cleaving
enzyme 2, EC 3.4.23. protein.
Length = 415
Score = 39.1 bits (87), Expect = 0.013
Identities = 21/66 (31%), Positives = 34/66 (51%)
Frame = +3
Query: 375 KVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLS 554
+++ DTGSSN V Y + +D+ +S TY + G ++Y GS +GF+
Sbjct: 3 QILVDTGSSNFAVAGTPHSY------IDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVG 56
Query: 555 TDDVTV 572
D VT+
Sbjct: 57 EDLVTI 62
>AL365205-3|CAM16152.1| 86|Homo sapiens progastricsin (pepsinogen
C) protein.
Length = 86
Score = 38.7 bits (86), Expect = 0.018
Identities = 28/70 (40%), Positives = 37/70 (52%), Gaps = 9/70 (12%)
Frame = +3
Query: 180 SVMALYRVPLHRMKTARTHFHEVGTELELLRL-KYDVT--------GPSPEPLSNYLDAQ 332
+V+ RVPL + K+ R E G E LR KYD + EP++ Y+DA
Sbjct: 18 AVICKQRVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMA-YMDAA 76
Query: 333 YYGVISIGTP 362
Y+G ISIGTP
Sbjct: 77 YFGEISIGTP 86
>AB089958-1|BAC81826.1| 127|Homo sapiens beta-site APP cleaving
enzyme isoform I-127 protein.
Length = 127
Score = 36.7 bits (81), Expect = 0.072
Identities = 19/53 (35%), Positives = 29/53 (54%)
Frame = +3
Query: 333 YYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTY 491
YY +++G+PPQ+ ++ DTGSSN V + + LH Y + S TY
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYYQRQLSSTY 121
>AF141344-1|AAG49447.1| 119|Homo sapiens LYST-interacting protein
LIP8 protein.
Length = 119
Score = 32.3 bits (70), Expect = 1.5
Identities = 13/33 (39%), Positives = 16/33 (48%)
Frame = -1
Query: 555 WRGSRRGCRSRTVSRTGCHSRRTSWTCGCRTCC 457
W GS+R C + V + S SW CR CC
Sbjct: 8 WPGSKRECANCRVGTSSWRSSGWSWWKDCRPCC 40
>AK055141-1|BAB70862.1| 260|Homo sapiens protein ( Homo sapiens
cDNA FLJ30579 fis, clone BRAWH2006989, weakly similar to
DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT (EC
2.7.7.6). ).
Length = 260
Score = 31.9 bits (69), Expect = 2.0
Identities = 17/35 (48%), Positives = 18/35 (51%)
Frame = -1
Query: 564 HHQWRGSRRGCRSRTVSRTGCHSRRTSWTCGCRTC 460
H+ W GS R C S T S G HS SWT R C
Sbjct: 26 HNSWTGSNRACSSWTGSTRG-HS---SWTGSSRAC 56
>BC030606-1|AAH30606.2| 514|Homo sapiens coiled-coil domain
containing 11 protein.
Length = 514
Score = 30.7 bits (66), Expect = 4.7
Identities = 12/26 (46%), Positives = 18/26 (69%)
Frame = -2
Query: 398 GSGVEYHLERLRRRADTDHSVVLSIK 321
G G E+HLER+RR ++++ SIK
Sbjct: 30 GQGAEHHLERIRRSHQKHNAILASIK 55
>BC035605-1|AAH35605.1| 578|Homo sapiens schlafen family member 12
protein.
Length = 578
Score = 25.4 bits (53), Expect(2) = 6.0
Identities = 12/51 (23%), Positives = 23/51 (45%)
Frame = -1
Query: 324 QDNLTMVRVKGQSHRILISTAPVQCQPHESGFSQFSYDVMAPYIVPLRSWR 172
+DN M + + + ++ P +E SQ + + AP+ PL W+
Sbjct: 325 KDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQINTSLPAPHSWPLLEWQ 375
Score = 23.4 bits (48), Expect(2) = 6.0
Identities = 8/27 (29%), Positives = 11/27 (40%)
Frame = -1
Query: 471 CRTCCAANKRCWCSGTFWKAPRGWRIR 391
C CA +C F K P W ++
Sbjct: 299 CGYVCALRVERFCCAVFAKEPDSWHVK 325
>AK001122-1|BAA91512.1| 578|Homo sapiens protein ( Homo sapiens
cDNA FLJ10260 fis, clone HEMBB1000973, moderately
similar to Mus musculus schlafen3 mRNA. ).
Length = 578
Score = 25.4 bits (53), Expect(2) = 6.0
Identities = 12/51 (23%), Positives = 23/51 (45%)
Frame = -1
Query: 324 QDNLTMVRVKGQSHRILISTAPVQCQPHESGFSQFSYDVMAPYIVPLRSWR 172
+DN M + + + ++ P +E SQ + + AP+ PL W+
Sbjct: 325 KDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQINASLPAPHSWPLLEWQ 375
Score = 23.4 bits (48), Expect(2) = 6.0
Identities = 8/27 (29%), Positives = 11/27 (40%)
Frame = -1
Query: 471 CRTCCAANKRCWCSGTFWKAPRGWRIR 391
C CA +C F K P W ++
Sbjct: 299 CGYVCALRVERFCCAVFAKEPDSWHVK 325
>BC133035-1|AAI33036.1| 129|Homo sapiens keratin associated protein
5-6 protein.
Length = 129
Score = 30.3 bits (65), Expect = 6.2
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -1
Query: 549 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 430
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
>BC130399-1|AAI30400.1| 129|Homo sapiens keratin associated protein
5-6 protein.
Length = 129
Score = 30.3 bits (65), Expect = 6.2
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -1
Query: 549 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 430
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
>AB126075-1|BAD20202.1| 129|Homo sapiens keratin associated protein
protein.
Length = 129
Score = 30.3 bits (65), Expect = 6.2
Identities = 17/40 (42%), Positives = 20/40 (50%)
Frame = -1
Query: 549 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCS 430
GS+ GC S S+ GC S CGC C K C+CS
Sbjct: 65 GSKGGCGSCGGSKGGCGS------CGCSQCSCC-KPCYCS 97
>AK096194-1|BAC04723.1| 138|Homo sapiens protein ( Homo sapiens
cDNA FLJ38875 fis, clone MESAN2013936. ).
Length = 138
Score = 29.9 bits (64), Expect = 8.2
Identities = 14/45 (31%), Positives = 19/45 (42%)
Frame = -1
Query: 534 CRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCSGTFWKAPRGW 400
C S T C R + C +CC + + C CS T+W W
Sbjct: 75 CLSEEAGETAC--RASPGQCYVTSCCLS-RHCTCSLTWWDVLLNW 116
>AB126079-1|BAD20206.1| 202|Homo sapiens keratin associated protein
protein.
Length = 202
Score = 29.9 bits (64), Expect = 8.2
Identities = 18/66 (27%), Positives = 29/66 (43%)
Frame = -1
Query: 549 GSRRGCRSRTVSRTGCHSRRTSWTCGCRTCCAANKRCWCSGTFWKAPRGWRIRCRIPP*T 370
GS+ GC S S+ GC S S C+ CC ++ C + P + C +P
Sbjct: 119 GSKGGCGSCGGSKGGCGSCGCSQCNCCKPCCCSSGCGSCCQSSCCNPCCCQSSCCVPVCC 178
Query: 369 TAAACR 352
++ C+
Sbjct: 179 QSSCCK 184
Database: human
Posted date: Oct 23, 2007 1:18 PM
Number of letters in database: 76,859,062
Number of sequences in database: 237,096
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 93,243,234
Number of Sequences: 237096
Number of extensions: 1982048
Number of successful extensions: 5733
Number of sequences better than 10.0: 79
Number of HSP's better than 10.0 without gapping: 5213
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5686
length of database: 76,859,062
effective HSP length: 87
effective length of database: 56,231,710
effective search space used: 7253890590
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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