Last updated: 2022/11/18
BLASTX 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= fdpeP26_F_M19
(1176 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI00015B4A18 Cluster: PREDICTED: similar to FPGS prote... 264 3e-69
UniRef50_UPI0000DB6E21 Cluster: PREDICTED: similar to folylpolyg... 262 2e-68
UniRef50_UPI0000E4A2B9 Cluster: PREDICTED: similar to Folylpolyg... 261 3e-68
UniRef50_Q05932 Cluster: Folylpolyglutamate synthase, mitochondr... 260 7e-68
UniRef50_UPI0000D556C6 Cluster: PREDICTED: similar to Folylpolyg... 253 8e-66
UniRef50_Q5TSB4 Cluster: ENSANGP00000026850; n=1; Anopheles gamb... 252 1e-65
UniRef50_Q5JU23 Cluster: Folylpolyglutamate synthase; n=2; Homo ... 250 4e-65
UniRef50_Q9VYL1 Cluster: CG2543-PA; n=4; Sophophora|Rep: CG2543-... 230 6e-59
UniRef50_Q5KJZ3 Cluster: Tetrahydrofolylpolyglutamate synthase, ... 219 1e-55
UniRef50_Q09509 Cluster: Putative folylpolyglutamate synthase; n... 214 4e-54
UniRef50_Q54CY5 Cluster: Tetrahydrofolylpolyglutamate synthase; ... 208 2e-52
UniRef50_O74742 Cluster: Probable folylpolyglutamate synthase; n... 208 2e-52
UniRef50_Q8W038 Cluster: Folylpolyglutamate synthetase, mitochon... 202 1e-50
UniRef50_Q08645 Cluster: Folylpolyglutamate synthase; n=7; Sacch... 202 1e-50
UniRef50_Q16KT7 Cluster: Folylpolyglutamate synthase; n=1; Aedes... 201 3e-50
UniRef50_Q4P7Z1 Cluster: Putative uncharacterized protein; n=1; ... 200 7e-50
UniRef50_Q2UUH9 Cluster: Folylpolyglutamate synthase; n=2; Eurot... 199 1e-49
UniRef50_O13492 Cluster: Folylpolyglutamate synthase; n=5; Peziz... 198 3e-49
UniRef50_Q8W040 Cluster: Folylpolyglutamate synthetase, chloropl... 193 6e-48
UniRef50_Q9M059 Cluster: Tetrahydrofolylpolyglutamate synthase-l... 191 3e-47
UniRef50_Q9Y893 Cluster: Folylpolyglutamate synthase; n=7; Sacch... 186 1e-45
UniRef50_Q2UGP7 Cluster: Folylpolyglutamate synthase; n=10; Pezi... 184 4e-45
UniRef50_UPI0000E484D2 Cluster: PREDICTED: similar to Folylpolyg... 177 5e-43
UniRef50_A4S2I3 Cluster: Predicted protein; n=2; Ostreococcus|Re... 171 2e-41
UniRef50_A7PIN0 Cluster: Chromosome chr13 scaffold_17, whole gen... 170 7e-41
UniRef50_A6R4T6 Cluster: Putative uncharacterized protein; n=2; ... 163 6e-39
UniRef50_A2QK88 Cluster: Contig An04c0360, complete genome; n=2;... 163 8e-39
UniRef50_A2QCB5 Cluster: Contig An02c0080, complete genome; n=6;... 156 9e-37
UniRef50_Q9VQW0 Cluster: CG31773-PA; n=1; Drosophila melanogaste... 155 2e-36
UniRef50_A6SID8 Cluster: Putative uncharacterized protein; n=1; ... 155 3e-36
UniRef50_UPI0000587E85 Cluster: PREDICTED: similar to Folylpolyg... 154 5e-36
UniRef50_Q4Q1G0 Cluster: Folylpolyglutamate synthetase; n=6; Try... 153 8e-36
UniRef50_A4RLF6 Cluster: Putative uncharacterized protein; n=1; ... 153 8e-36
UniRef50_Q8XJ43 Cluster: Folyl-polyglutamate synthetase; n=13; C... 152 2e-35
UniRef50_Q4THS1 Cluster: Chromosome undetermined SCAF2726, whole... 151 3e-35
UniRef50_UPI000023EDF3 Cluster: hypothetical protein FG00685.1; ... 147 4e-34
UniRef50_A7CTY2 Cluster: FolC bifunctional protein; n=1; Opituta... 147 4e-34
UniRef50_A7EG57 Cluster: Putative uncharacterized protein; n=1; ... 147 4e-34
UniRef50_Q6A9I9 Cluster: Folylpolyglutamate synthase; n=1; Propi... 146 7e-34
UniRef50_A3IEY2 Cluster: Folyl-polyglutamate synthetase; n=1; Ba... 146 1e-33
UniRef50_Q01UR3 Cluster: FolC bifunctional protein; n=1; Solibac... 144 3e-33
UniRef50_A6C8Q2 Cluster: Folyl-polyglutamate synthetase; n=1; Pl... 143 7e-33
UniRef50_A6PUD4 Cluster: FolC bifunctional protein; n=1; Victiva... 142 1e-32
UniRef50_Q38AL2 Cluster: Folylpolyglutamate-dihydrofolate synthe... 142 1e-32
UniRef50_A5FMS8 Cluster: FolC bifunctional protein; n=14; Bacter... 142 2e-32
UniRef50_Q5C3N8 Cluster: SJCHGC04288 protein; n=1; Schistosoma j... 141 3e-32
UniRef50_A2G107 Cluster: FolC bifunctional protein; n=1; Trichom... 141 3e-32
UniRef50_Q97SN7 Cluster: Dihydrofolate synthetase; n=15; Strepto... 140 5e-32
UniRef50_Q64S09 Cluster: Folylpolyglutamate synthase; n=2; Bacte... 140 5e-32
UniRef50_Q1PZI3 Cluster: Similar to multifunctional folylpolyglu... 138 3e-31
UniRef50_A6BCX0 Cluster: Putative uncharacterized protein; n=2; ... 138 3e-31
UniRef50_Q2JLQ4 Cluster: Folylpolyglutamate synthase; n=2; Synec... 138 3e-31
UniRef50_A4RKT0 Cluster: Putative uncharacterized protein; n=1; ... 138 3e-31
UniRef50_A6LA17 Cluster: Folylpolyglutamate synthase; n=2; Parab... 137 4e-31
UniRef50_A6TN35 Cluster: FolC bifunctional protein; n=2; Clostri... 137 6e-31
UniRef50_Q11UV3 Cluster: Tetrahydrofolylpolyglutamate synthase; ... 136 8e-31
UniRef50_Q03Z01 Cluster: Folylpolyglutamate synthase; n=1; Leuco... 136 8e-31
UniRef50_Q18QE7 Cluster: FolC bifunctional protein; n=5; Clostri... 136 1e-30
UniRef50_Q04E69 Cluster: Folylpolyglutamate synthase; n=2; Oenoc... 136 1e-30
UniRef50_A5KJF0 Cluster: Putative uncharacterized protein; n=2; ... 136 1e-30
UniRef50_A5D456 Cluster: Folylpolyglutamate synthase; n=1; Pelot... 136 1e-30
UniRef50_Q8G4M5 Cluster: Folylpolyglutamate synthase; n=4; Bifid... 136 1e-30
UniRef50_A3ZWP1 Cluster: Folyl-polyglutamate synthetase; n=1; Bl... 135 2e-30
UniRef50_Q8W041 Cluster: Dihydrofolate synthetase; n=5; core eud... 135 2e-30
UniRef50_Q7NLP7 Cluster: Folylpolyglutamate synthase; n=1; Gloeo... 134 4e-30
UniRef50_A3HTE9 Cluster: Folylpolyglutamate synthase; n=3; Bacte... 134 4e-30
UniRef50_Q1EVW0 Cluster: Folylpolyglutamate synthetase; n=1; Clo... 134 6e-30
UniRef50_A7LS10 Cluster: Putative uncharacterized protein; n=1; ... 134 6e-30
UniRef50_Q1IVH6 Cluster: FolC bifunctional protein; n=1; Acidoba... 132 1e-29
UniRef50_A4M5Q3 Cluster: FolC bifunctional protein; n=1; Petroto... 132 2e-29
UniRef50_A5ZI35 Cluster: Putative uncharacterized protein; n=1; ... 132 2e-29
UniRef50_A5KLT5 Cluster: Putative uncharacterized protein; n=1; ... 132 2e-29
UniRef50_Q82ZW9 Cluster: FolC family protein; n=7; Firmicutes|Re... 131 4e-29
UniRef50_Q7UQM1 Cluster: Folylpolyglutamate synthase/dihydrofola... 130 7e-29
UniRef50_Q2RZW2 Cluster: Dihydrofolate synthetase; n=1; Saliniba... 130 7e-29
UniRef50_Q7SFD9 Cluster: Putative uncharacterized protein NCU008... 130 9e-29
UniRef50_A7D4G5 Cluster: Dihydropteroate synthase; n=1; Halorubr... 130 9e-29
UniRef50_Q1FIY8 Cluster: FolC bifunctional protein; n=1; Clostri... 129 2e-28
UniRef50_A6WDS1 Cluster: FolC bifunctional protein precursor; n=... 128 2e-28
UniRef50_Q2RNS0 Cluster: Folylpolyglutamate synthetase; n=4; Rho... 128 3e-28
UniRef50_Q04MP6 Cluster: Folylpolyglutamate synthase; n=14; Stre... 128 3e-28
UniRef50_Q5CBK3 Cluster: Folylpolyglutamate synthase/dihydrofola... 128 4e-28
UniRef50_A6DMK1 Cluster: Folylpolyglutamate synthase; n=1; Lenti... 128 4e-28
UniRef50_A1HP48 Cluster: FolC bifunctional protein; n=1; Thermos... 128 4e-28
UniRef50_Q05865 Cluster: Folylpolyglutamate synthase; n=4; Bacil... 128 4e-28
UniRef50_A0LIV6 Cluster: FolC bifunctional protein; n=1; Syntrop... 127 5e-28
UniRef50_Q9K8G9 Cluster: Folyl-polyglutamate synthetase; n=1; Ba... 127 6e-28
UniRef50_Q727H3 Cluster: Folylpolyglutamate synthase; n=2; Desul... 127 6e-28
UniRef50_A5VL10 Cluster: FolC bifunctional protein; n=2; Lactoba... 127 6e-28
UniRef50_A5FP87 Cluster: FolC bifunctional protein; n=3; Dehaloc... 126 8e-28
UniRef50_Q92BG3 Cluster: FolC protein; n=11; Listeria|Rep: FolC ... 126 1e-27
UniRef50_Q8RBN3 Cluster: Folylpolyglutamate synthase; n=5; Clost... 126 1e-27
UniRef50_Q6AJ73 Cluster: Related to folylpolyglutamate synthase;... 126 1e-27
UniRef50_Q8A839 Cluster: Folylpolyglutamate synthase; n=1; Bacte... 126 1e-27
UniRef50_Q73NR8 Cluster: Folylpolyglutamate synthetase, putative... 126 1e-27
UniRef50_Q2GD55 Cluster: Folylpolyglutamate synthase; n=1; Neori... 126 1e-27
UniRef50_A7HDB5 Cluster: FolC bifunctional protein; n=2; Anaerom... 126 1e-27
UniRef50_A4VSD9 Cluster: Folylpolyglutamate synthase; n=2; Strep... 126 1e-27
UniRef50_A0UYZ7 Cluster: FolC bifunctional protein; n=1; Clostri... 126 1e-27
UniRef50_Q2LQC5 Cluster: Folylpolyglutamate synthase / dihydrofo... 125 2e-27
UniRef50_Q0LMK1 Cluster: FolC bifunctional protein; n=1; Herpeto... 125 2e-27
UniRef50_A5Z386 Cluster: Putative uncharacterized protein; n=1; ... 125 2e-27
UniRef50_A5V1W9 Cluster: FolC bifunctional protein; n=2; Roseifl... 125 2e-27
UniRef50_A4XL37 Cluster: FolC bifunctional protein; n=2; Clostri... 125 2e-27
UniRef50_Q1WT76 Cluster: Folylpolyglutamate synthase / Dihydrofo... 125 3e-27
UniRef50_A5ZW55 Cluster: Putative uncharacterized protein; n=1; ... 125 3e-27
UniRef50_A3TFM8 Cluster: Putative folylpolyglutamate synthase; n... 124 3e-27
UniRef50_Q0GL77 Cluster: Folylpolyglutamate synthase; n=3; Lacto... 124 4e-27
UniRef50_A5CR24 Cluster: FolC protein; n=4; Actinobacteria (clas... 124 4e-27
UniRef50_Q1D8V1 Cluster: Tetrahydrofolylpolyglutamate synthase/d... 124 6e-27
UniRef50_Q6DKZ3 Cluster: Dihydrofolate/folylpolyglutamate syntha... 124 6e-27
UniRef50_A5K2Z0 Cluster: Dihydrofolate synthase/folylpolyglutama... 124 6e-27
UniRef50_A1ZCQ8 Cluster: Folylpolyglutamate synthase; n=1; Micro... 123 8e-27
UniRef50_Q9U738 Cluster: Dihydrofolate synthase/folylpolyglutama... 123 8e-27
UniRef50_Q0AWF7 Cluster: Putative uncharacterized protein; n=1; ... 123 1e-26
UniRef50_Q38XD0 Cluster: Putative polylpolyglutamate synthase; n... 122 1e-26
UniRef50_Q4AKU0 Cluster: Folylpolyglutamate synthetase; n=1; Chl... 122 1e-26
UniRef50_Q2QLY6 Cluster: Dihydrofolate synthetase/folylpolygluta... 122 1e-26
UniRef50_P43775 Cluster: Folylpolyglutamate synthase; n=101; Gam... 122 2e-26
UniRef50_Q7MWW9 Cluster: Folylpolyglutamate synthase; n=2; Bacte... 122 2e-26
UniRef50_Q31PP5 Cluster: FolC bifunctional protein; n=2; Synecho... 122 2e-26
UniRef50_Q3DZP5 Cluster: Folylpolyglutamate synthetase; n=2; Chl... 122 2e-26
UniRef50_A3VQ98 Cluster: FolC bifunctional protein; n=1; Parvula... 122 2e-26
UniRef50_Q6MAP9 Cluster: Putative folylpolyglutamate synthase; n... 121 3e-26
UniRef50_A1SMD5 Cluster: FolC bifunctional protein; n=5; Actinom... 121 3e-26
UniRef50_Q8EPN5 Cluster: Folyl-polyglutamate synthase; n=1; Ocea... 121 4e-26
UniRef50_Q40KD4 Cluster: Folylpolyglutamate synthetase; n=12; Ri... 120 6e-26
UniRef50_Q1JY09 Cluster: FolC bifunctional protein; n=1; Desulfu... 120 1e-25
UniRef50_Q03EP1 Cluster: Folylpolyglutamate synthase; n=1; Pedio... 119 1e-25
UniRef50_A0LA36 Cluster: FolC bifunctional protein; n=2; cellula... 119 1e-25
UniRef50_Q88UX8 Cluster: Folylpolyglutamate synthase; n=2; Lacto... 119 2e-25
UniRef50_Q5VAN8 Cluster: FolC; n=63; Alphaproteobacteria|Rep: Fo... 118 2e-25
UniRef50_Q5KWL4 Cluster: Folyl-polyglutamate synthetase; n=16; B... 118 3e-25
UniRef50_Q03Y79 Cluster: Folylpolyglutamate synthase; n=1; Leuco... 118 3e-25
UniRef50_Q00X21 Cluster: Dihydrofolate synthetase /folylpolyglut... 118 3e-25
UniRef50_Q8KFQ9 Cluster: Folylpolyglutamate synthase; n=1; Chlor... 118 4e-25
UniRef50_Q41DX5 Cluster: Folylpolyglutamate synthetase; n=1; Exi... 118 4e-25
UniRef50_A3ESF6 Cluster: Folylpolyglutamate synthase; n=1; Lepto... 118 4e-25
UniRef50_Q5FRN0 Cluster: Folylpolyglutamate synthase / dihydrofo... 117 5e-25
UniRef50_Q6M382 Cluster: FOLYLPOLYGLUTAMATE SYNTHASE; n=32; Acti... 117 5e-25
UniRef50_Q5SLF0 Cluster: Folyl-polyglutamate synthetase; n=4; De... 117 7e-25
UniRef50_Q30WU4 Cluster: FolC bifunctional protein; n=1; Desulfo... 117 7e-25
UniRef50_Q9HS44 Cluster: Dihydropteroate synthase; n=4; Halobact... 117 7e-25
UniRef50_Q8UJA7 Cluster: Folylpolyglutamate synthase; n=2; Agrob... 116 1e-24
UniRef50_P73842 Cluster: Folyl-polyglutamate synthetase; n=10; C... 116 1e-24
UniRef50_Q11KL3 Cluster: FolC bifunctional protein; n=4; Rhizobi... 116 2e-24
UniRef50_A7HJX6 Cluster: FolC bifunctional protein; n=2; Thermot... 116 2e-24
UniRef50_Q3A6L0 Cluster: Folylpolyglutamate synthetase; dihydrof... 115 2e-24
UniRef50_Q12D50 Cluster: FolC bifunctional protein; n=1; Polarom... 115 2e-24
UniRef50_A5GRK4 Cluster: FolC bifunctional protein; n=2; Synecho... 115 2e-24
UniRef50_A3IEY3 Cluster: FolC; n=1; Bacillus sp. B14905|Rep: Fol... 115 2e-24
UniRef50_Q2HAU4 Cluster: Putative uncharacterized protein; n=1; ... 115 2e-24
UniRef50_Q5WEQ5 Cluster: Folylpolyglutamate synthase; n=1; Bacil... 115 3e-24
UniRef50_O67833 Cluster: Folylpolyglutamate synthetase; n=1; Aqu... 115 3e-24
UniRef50_Q7VRV1 Cluster: Folylpolyglutamate synthase; n=2; Candi... 114 4e-24
UniRef50_O83360 Cluster: Folylpolyglutamate synthetase; n=1; Tre... 114 4e-24
UniRef50_Q2VIK1 Cluster: Dihydrofolate synthase; n=1; Pneumocyst... 114 5e-24
UniRef50_Q74AI6 Cluster: FolC bifunctional protein; n=5; Geobact... 113 8e-24
UniRef50_Q6FEE4 Cluster: Bifunctional protein [Includes: folylpo... 113 8e-24
UniRef50_Q67SJ1 Cluster: Folylpolyglutamate synthase; n=1; Symbi... 113 8e-24
UniRef50_Q31HH1 Cluster: FolC bifunctional folylpolyglutamate sy... 113 8e-24
UniRef50_A4B0Z4 Cluster: Bifunctional folylpolyglutamate synthas... 113 8e-24
UniRef50_Q68WJ9 Cluster: Folylpolyglutamate synthase; n=11; Rick... 113 1e-23
UniRef50_A5TUM3 Cluster: Tetrahydrofolate synthase; n=3; Fusobac... 113 1e-23
UniRef50_A4A847 Cluster: Folylpolyglutamate synthase/dihydrofola... 113 1e-23
UniRef50_Q6B7M6 Cluster: FolC-P protein; n=1; Haloferax volcanii... 113 1e-23
UniRef50_Q38WN1 Cluster: Folylpolyglutamate synthase; n=1; Lacto... 112 1e-23
UniRef50_Q9FN53 Cluster: Folylpolyglutamate synthase-like protei... 112 1e-23
UniRef50_Q5QWH7 Cluster: Folylpolyglutamate synthase; n=2; Idiom... 112 2e-23
UniRef50_Q83G53 Cluster: Folylpolyglutamate synthase; n=2; Troph... 111 3e-23
UniRef50_A5WDG9 Cluster: FolC bifunctional protein; n=3; Psychro... 111 3e-23
UniRef50_A6D0N3 Cluster: Folylpolyglutamate synthase; n=1; Vibri... 111 4e-23
UniRef50_A1K4B2 Cluster: Dihydrofolate synthase / Tetrahydrofoly... 111 4e-23
UniRef50_Q6BKI0 Cluster: Debaryomyces hansenii chromosome F of s... 111 4e-23
UniRef50_A1CXV3 Cluster: Dihydrofolate synthetase Fol3; n=11; Pe... 111 4e-23
UniRef50_Q88ST5 Cluster: Folylpolyglutamate synthase; n=1; Lacto... 110 6e-23
UniRef50_Q5FKW4 Cluster: Folylpolyglutamate synthase; n=6; Lacto... 110 6e-23
UniRef50_A4BHC7 Cluster: FolC bifunctional folylpolyglutamate sy... 110 6e-23
UniRef50_A4QWG8 Cluster: Putative uncharacterized protein; n=1; ... 110 8e-23
UniRef50_Q1MS38 Cluster: Folylpolyglutamate synthase; n=1; Lawso... 109 1e-22
UniRef50_P15925 Cluster: Folylpolyglutamate synthase; n=2; Lacto... 109 1e-22
UniRef50_Q15VG0 Cluster: FolC bifunctional protein; n=1; Pseudoa... 109 1e-22
UniRef50_A7C245 Cluster: Folylpolyglutamate synthase/dihydrofola... 109 2e-22
UniRef50_Q9RXH3 Cluster: Folyl-polyglutamate synthetase; n=2; De... 108 2e-22
UniRef50_Q9CN13 Cluster: FolC; n=7; Pasteurellaceae|Rep: FolC - ... 108 2e-22
UniRef50_Q6KZL1 Cluster: Folylpolyglutamate synthase/dihydrofola... 108 2e-22
UniRef50_Q3B220 Cluster: Folylpolyglutamate synthetase; n=7; Chl... 108 3e-22
UniRef50_UPI00005100A3 Cluster: COG0285: Folylpolyglutamate synt... 107 5e-22
UniRef50_Q62AJ8 Cluster: FolC bifunctional protein; n=25; Betapr... 107 5e-22
UniRef50_Q3JCB5 Cluster: Folylpolyglutamate synthetase; n=1; Nit... 107 5e-22
UniRef50_Q0ATK3 Cluster: FolC bifunctional protein; n=1; Maricau... 107 5e-22
UniRef50_A1W9F5 Cluster: FolC bifunctional protein; n=33; Burkho... 107 5e-22
UniRef50_Q1GU94 Cluster: FolC bifunctional protein; n=5; Sphingo... 107 7e-22
UniRef50_Q0USC9 Cluster: Putative uncharacterized protein; n=1; ... 107 7e-22
UniRef50_Q0AGX2 Cluster: FolC bifunctional protein; n=1; Nitroso... 106 1e-21
UniRef50_Q5V5Y3 Cluster: Dihydropteroate synthase; n=1; Haloarcu... 106 1e-21
UniRef50_Q97AP2 Cluster: Folylpolyglutamate synthase; n=2; Therm... 106 1e-21
UniRef50_Q2ZYL0 Cluster: Folylpolyglutamate synthetase; n=5; Str... 105 2e-21
UniRef50_A4E6Z7 Cluster: Putative uncharacterized protein; n=1; ... 105 2e-21
UniRef50_Q12676 Cluster: Folylpolyglutamate synthase; n=5; Sacch... 105 2e-21
UniRef50_A6FEP3 Cluster: Dihydrofolate synthase / folylpolygluta... 105 2e-21
UniRef50_A4BRV9 Cluster: Folylpolyglutamate synthase/dihydrofola... 105 2e-21
UniRef50_Q4UH02 Cluster: Dihydrofolate synthase/folylpolyglutama... 105 2e-21
UniRef50_Q8K9X3 Cluster: Bifunctional protein folC [Includes: Fo... 105 2e-21
UniRef50_A6SPC7 Cluster: Putative uncharacterized protein; n=2; ... 105 3e-21
UniRef50_Q8D2P3 Cluster: FolC protein; n=1; Wigglesworthia gloss... 104 4e-21
UniRef50_Q0A999 Cluster: FolC bifunctional protein; n=1; Alkalil... 104 4e-21
UniRef50_A0W7P3 Cluster: FolC bifunctional protein precursor; n=... 104 4e-21
UniRef50_Q6CHD4 Cluster: Similar to sp|Q12676 Saccharomyces cere... 104 4e-21
UniRef50_A5DAQ6 Cluster: Putative uncharacterized protein; n=1; ... 103 7e-21
UniRef50_Q0BWJ9 Cluster: Putative folylpolyglutamate synthase; n... 103 1e-20
UniRef50_A5IBI5 Cluster: FolC bifunctional protein; n=4; Legione... 103 1e-20
UniRef50_Q89AT2 Cluster: Bifunctional protein folC [Includes: Fo... 103 1e-20
UniRef50_Q1N6P7 Cluster: Folylpolyglutamate synthetase; n=1; Oce... 102 2e-20
UniRef50_A3JGB7 Cluster: Folylpolyglutamate synthetase; n=3; Mar... 102 2e-20
UniRef50_Q83D50 Cluster: FolC bifunctional protein; n=4; Coxiell... 102 2e-20
UniRef50_A0ECV5 Cluster: Chromosome undetermined scaffold_9, who... 102 2e-20
UniRef50_A6REJ0 Cluster: Putative uncharacterized protein; n=1; ... 102 2e-20
UniRef50_Q9HZA8 Cluster: Folylpolyglutamate synthetase; n=18; Ps... 101 3e-20
UniRef50_Q14PS6 Cluster: Hypothetical folylpolyglutamate synthas... 101 3e-20
UniRef50_Q9UTD0 Cluster: Folylpolyglutamate synthase; n=1; Schiz... 101 3e-20
UniRef50_Q2G8T0 Cluster: FolC bifunctional protein; n=3; Sphingo... 101 4e-20
UniRef50_Q2SJC8 Cluster: Folylpolyglutamate synthase; n=1; Hahel... 101 5e-20
UniRef50_Q1QY39 Cluster: FolC bifunctional protein; n=1; Chromoh... 101 5e-20
UniRef50_A6QBX4 Cluster: Folylpolyglutamate synthase; n=1; Sulfu... 101 5e-20
UniRef50_A4CD05 Cluster: Bifunctional: folylpolyglutamate syntha... 101 5e-20
UniRef50_Q9X7F5 Cluster: FolC protein; n=1; Methylobacterium chl... 100 6e-20
UniRef50_A7DJF5 Cluster: FolC bifunctional protein; n=1; Methylo... 100 6e-20
UniRef50_Q59S44 Cluster: Putative uncharacterized protein; n=2; ... 100 6e-20
UniRef50_UPI0000E0E8A2 Cluster: FolC bifunctional protein; n=1; ... 100 8e-20
UniRef50_UPI000023EB67 Cluster: hypothetical protein FG10379.1; ... 100 8e-20
UniRef50_A3S1I7 Cluster: Folylpolyglutamate synthase; n=1; Proch... 100 8e-20
UniRef50_A1AXP8 Cluster: FolC bifunctional protein; n=3; Bacteri... 100 8e-20
UniRef50_Q5KCY2 Cluster: Dihydrofolate synthase, putative; n=1; ... 99 1e-19
UniRef50_Q12P54 Cluster: FolC bifunctional protein; n=6; Shewane... 100 1e-19
UniRef50_Q9PC39 Cluster: Folylpolyglutamate synthase/dihydrofola... 99 2e-19
UniRef50_Q7TU62 Cluster: Putuative bifunctional Dihydrofolate/Fo... 99 2e-19
UniRef50_Q21IZ3 Cluster: FolC bifunctional protein; n=1; Sacchar... 99 2e-19
UniRef50_A5EVX7 Cluster: Folylpolyglutamate synthase; n=1; Diche... 99 3e-19
UniRef50_A1WY03 Cluster: FolC bifunctional protein; n=1; Halorho... 99 3e-19
UniRef50_A0YB05 Cluster: FolC bifunctional protein; n=1; marine ... 99 3e-19
UniRef50_UPI0000E88026 Cluster: folylpolyglutamate synthetase; n... 98 3e-19
UniRef50_Q2JDQ6 Cluster: FolC bifunctional protein; n=2; Frankia... 98 3e-19
UniRef50_Q1JHI7 Cluster: Folylpolyglutamate synthase / Dihydrofo... 98 3e-19
UniRef50_Q7VAS8 Cluster: Folylpolyglutamate synthase; n=3; Proch... 97 6e-19
UniRef50_Q49Y95 Cluster: Folylpolyglutamate synthase; n=16; Stap... 97 6e-19
UniRef50_Q2BMN3 Cluster: Folylpolyglutamate synthase; n=1; Neptu... 97 8e-19
UniRef50_A6VWY8 Cluster: FolC bifunctional protein; n=2; Marinom... 97 8e-19
UniRef50_A6DD55 Cluster: Folylpolyglutamate synthetase; n=1; Cam... 97 1e-18
UniRef50_Q72J06 Cluster: Folylpolyglutamate synthase/dihydrofola... 96 2e-18
UniRef50_Q13EI5 Cluster: FolC bifunctional protein; n=3; Rhodops... 95 2e-18
UniRef50_Q0P9G6 Cluster: Folylpolyglutamate synthase/dihydrofola... 95 2e-18
UniRef50_Q0EXD2 Cluster: Folylpolyglutamate synthetase; n=1; Mar... 95 2e-18
UniRef50_A0Z5L0 Cluster: Folylpolyglutamate synthase/dihydrofola... 95 2e-18
UniRef50_Q604P6 Cluster: Folylpolyglutamate synthase/dihydrofola... 95 3e-18
UniRef50_Q1GBX7 Cluster: Folylpolyglutamate synthase; n=2; Lacto... 95 3e-18
UniRef50_A1SW71 Cluster: FolC bifunctional protein; n=2; Psychro... 95 3e-18
UniRef50_A6G512 Cluster: FolC bifunctional protein; n=1; Plesioc... 93 1e-17
UniRef50_A6Q510 Cluster: Folylpolyglutamate synthase; n=1; Nitra... 93 1e-17
UniRef50_Q758R3 Cluster: AEL310Cp; n=1; Eremothecium gossypii|Re... 93 1e-17
UniRef50_Q0VPJ2 Cluster: Folylpolyglutamate synthase / dihydrofo... 93 2e-17
UniRef50_UPI00015BCA34 Cluster: UPI00015BCA34 related cluster; n... 92 2e-17
UniRef50_Q8F8C1 Cluster: FolC bifunctional protein; n=4; Leptosp... 92 2e-17
UniRef50_Q1YT82 Cluster: Folylpolyglutamate synthetase; n=2; Pro... 92 2e-17
UniRef50_UPI0000DAE3B7 Cluster: hypothetical protein Rgryl_01000... 92 3e-17
UniRef50_Q4P0W7 Cluster: Putative uncharacterized protein; n=1; ... 91 4e-17
UniRef50_Q96G81 Cluster: Folylpolyglutamate synthase; n=2; Euthe... 91 5e-17
UniRef50_Q0ILT5 Cluster: Os12g0623800 protein; n=2; Oryza sativa... 90 9e-17
UniRef50_A2XBN3 Cluster: Putative uncharacterized protein; n=2; ... 89 2e-16
UniRef50_Q7NL38 Cluster: Folyl-polyglutamate synthetase; n=1; Gl... 89 2e-16
UniRef50_O26070 Cluster: Folylpolyglutamate synthase; n=4; Helic... 89 2e-16
UniRef50_Q3AV81 Cluster: Folylpolyglutamate synthetase; n=11; Cy... 88 5e-16
UniRef50_Q1AVT2 Cluster: FolC bifunctional protein; n=1; Rubroba... 87 6e-16
UniRef50_Q0AQK7 Cluster: FolC bifunctional protein; n=1; Maricau... 87 1e-15
UniRef50_Q2SR89 Cluster: Folate synthetase-polyglutamyl folate s... 85 3e-15
UniRef50_A7I0L8 Cluster: Folylpolyglutamate synthase; n=4; Campy... 85 3e-15
UniRef50_Q47XK6 Cluster: FolC bifunctional protein; n=1; Colwell... 84 6e-15
UniRef50_Q2A2S3 Cluster: FolC Bifunctional protein; n=11; Franci... 83 1e-14
UniRef50_A6R127 Cluster: Putative uncharacterized protein; n=1; ... 82 2e-14
UniRef50_Q7VIZ0 Cluster: Folylpolyglutamate synthase; n=1; Helic... 82 3e-14
UniRef50_Q4FND2 Cluster: FolC bifunctional protein; n=2; Candida... 79 2e-13
UniRef50_Q30Q85 Cluster: Folylpolyglutamate synthetase; n=1; Thi... 79 2e-13
UniRef50_Q7M927 Cluster: FOLYLPOLYGLUTAMATE SYNTHASE; n=1; Wolin... 79 3e-13
UniRef50_A3C692 Cluster: Putative uncharacterized protein; n=2; ... 74 8e-12
UniRef50_Q22WV2 Cluster: FolC bifunctional protein; n=1; Tetrahy... 73 2e-11
UniRef50_A4RLF9 Cluster: Putative uncharacterized protein; n=1; ... 71 8e-11
UniRef50_Q3VQY2 Cluster: Folylpolyglutamate synthetase; n=1; Pro... 69 2e-10
UniRef50_A5ZWM5 Cluster: Putative uncharacterized protein; n=1; ... 64 9e-09
UniRef50_A5ZWM4 Cluster: Putative uncharacterized protein; n=1; ... 63 1e-08
UniRef50_Q1VHQ7 Cluster: FolC bifunctional protein; n=1; Psychro... 51 7e-05
UniRef50_Q2HCU3 Cluster: Putative uncharacterized protein; n=1; ... 50 9e-05
UniRef50_A6R8F1 Cluster: Predicted protein; n=1; Ajellomyces cap... 47 8e-04
UniRef50_P36001 Cluster: Probable folylpolyglutamate synthase; n... 47 8e-04
UniRef50_A7RZ44 Cluster: Predicted protein; n=1; Nematostella ve... 39 0.22
UniRef50_UPI0000D8A08C Cluster: dihydrofolate/folylpolyglutamate... 39 0.29
UniRef50_A0L5N6 Cluster: UDP-N-acetylmuramyl-tripeptide syntheta... 38 0.66
UniRef50_Q25548 Cluster: Penicillin amidase homolog; n=1; Naegle... 37 0.88
UniRef50_Q896Z4 Cluster: Transcriptional regulatory protein; n=4... 36 2.7
UniRef50_UPI0000EB1C7B Cluster: Exocyst complex component 3 (Exo... 35 4.7
UniRef50_A7NT57 Cluster: Chromosome chr18 scaffold_1, whole geno... 34 6.2
>UniRef50_UPI00015B4A18 Cluster: PREDICTED: similar to FPGS protein,
partial; n=1; Nasonia vitripennis|Rep: PREDICTED: similar
to FPGS protein, partial - Nasonia vitripennis
Length = 571
Score = 264 bits (647), Expect = 3e-69
Identities = 130/244 (53%), Positives = 176/244 (72%)
Frame = +3
Query: 294 VRMCSYYEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDEL 473
+++ +Y+ AVR LN LQSN + I+ R+ T T L++ + YL R+G+T+ +LD+L
Sbjct: 37 LQLQAYHPEAVRSLNSLQSNAAYIKVARQLSPTEN--TTLQETKKYLIRSGLTLEQLDQL 94
Query: 474 SVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYF 653
SV+HVAGTKGKGST A E+ILR HGFRTGFYSSPHL++VRER R+NGR I+E F+++F
Sbjct: 95 SVIHVAGTKGKGSTCAFTEAILREHGFRTGFYSSPHLISVRERFRINGRPINELEFSRHF 154
Query: 654 HDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
V L+ ++ + DMP+YF FLT++ +++F+K VDVAI+EVGIGG D TNI+
Sbjct: 155 WHVFNILQQKKETDSDMPQYFKFLTILMFHVFIKANVDVAILEVGIGGEYDCTNIINSSV 214
Query: 834 VVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
GI++LGLDHTS+LG+T++ IA KAGI K G A+TVQQPN+AM VL A CPL
Sbjct: 215 CTGISSLGLDHTSLLGDTLESIAYHKAGIFKPGVPAFTVQQPNDAMTVLQARAVEKSCPL 274
Query: 1014 TXVP 1025
VP
Sbjct: 275 HVVP 278
>UniRef50_UPI0000DB6E21 Cluster: PREDICTED: similar to
folylpolyglutamate synthase; n=1; Apis mellifera|Rep:
PREDICTED: similar to folylpolyglutamate synthase - Apis
mellifera
Length = 440
Score = 262 bits (641), Expect = 2e-68
Identities = 129/242 (53%), Positives = 172/242 (71%)
Frame = +3
Query: 306 SYYEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVH 485
S YE A++KL LQSN + ++ K+ L D YL R+G+T+ KLD LSV+H
Sbjct: 14 SSYEAAIKKLCGLQSNSTYLKLATKNNSQTSDTYKLLDTIKYLVRSGITLEKLDTLSVIH 73
Query: 486 VAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVH 665
VAGTKGKGST A E+ILR HGF+TGF+SSPHL++ RER+RLNG+ ISE F + F ++
Sbjct: 74 VAGTKGKGSTCAYTEAILREHGFKTGFFSSPHLISARERIRLNGQPISEMHFTQNFWKIY 133
Query: 666 QRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGI 845
++LEDT+++E DMP YF FLTV+ +N+FL E VDVAI+EVGIGGL D TNI+R VGI
Sbjct: 134 KKLEDTREYESDMPAYFNFLTVLMFNVFLDEHVDVAIIEVGIGGLYDCTNIVRNPVCVGI 193
Query: 846 TALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXVP 1025
T+LGLDHTS+LGN++++IA K+GI K A++V Q +AM +L + A C L VP
Sbjct: 194 TSLGLDHTSLLGNSLEDIAYQKSGIFKSETIAFSVPQLPQAMYILEKRAIEKNCKLHIVP 253
Query: 1026 XY 1031
+
Sbjct: 254 TF 255
>UniRef50_UPI0000E4A2B9 Cluster: PREDICTED: similar to
Folylpolyglutamate synthase; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to Folylpolyglutamate
synthase - Strongylocentrotus purpuratus
Length = 647
Score = 261 bits (639), Expect = 3e-68
Identities = 130/239 (54%), Positives = 175/239 (73%), Gaps = 1/239 (0%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y+ A+RKLN LQSN T+++IRK+ G N+ D+ + +R G+++ +LDELS +HVA
Sbjct: 47 YQEAIRKLNTLQSNAKTLDEIRKNRDMGAY-KNIPDVIDGATRVGISLERLDELSCIHVA 105
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
GTKGKGS A ESILR GF+TGFYSSPHLV VRER+R+NG+ + ++ FAK F V+ R
Sbjct: 106 GTKGKGSVCAFTESILRASGFKTGFYSSPHLVEVRERIRINGQPLPKEDFAKNFFTVYNR 165
Query: 672 LEDTQK-FEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGIT 848
LE T++ ++G MP YF FLT++A++ FL+EKVDVAI+EVGIGG D TNI+RK VVGIT
Sbjct: 166 LEATKEDYDGKMPAYFRFLTLLAFHTFLEEKVDVAIMEVGIGGEYDCTNIIRKPVVVGIT 225
Query: 849 ALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXVP 1025
+LG+DH +LGNTI +IA KAGI+K G A+TV QP ++ V+ + A + L VP
Sbjct: 226 SLGIDHIGVLGNTIDKIAWHKAGIIKSGRPAFTVPQPENSIQVIKERAREKEASLQVVP 284
>UniRef50_Q05932 Cluster: Folylpolyglutamate synthase, mitochondrial
precursor; n=34; Euteleostomi|Rep: Folylpolyglutamate
synthase, mitochondrial precursor - Homo sapiens (Human)
Length = 587
Score = 260 bits (636), Expect = 7e-68
Identities = 125/239 (52%), Positives = 172/239 (71%), Gaps = 1/239 (0%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y+ AVR LN LQ+N +EQ+++ + G T LE ME YL+R+G+ + LD L+++HV
Sbjct: 45 YQDAVRMLNTLQTNAGYLEQVKR--QRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVT 102
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
GTKGKGST A E ILR +G +TGF+SSPHLV VRER+R+NG+ IS ++F KYF ++ R
Sbjct: 103 GTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHR 162
Query: 672 LEDTQKFEG-DMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGIT 848
LE+T+ MP YF FLT+MA+++FL+EKVD+A+VEVGIGG D TNI+RK V G++
Sbjct: 163 LEETKDGSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVS 222
Query: 849 ALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXVP 1025
+LG+DHTS+LG+T+++IA K GI K+G A+TV QP + VL A + CPL P
Sbjct: 223 SLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCP 281
>UniRef50_UPI0000D556C6 Cluster: PREDICTED: similar to
Folylpolyglutamate synthase, mitochondrial precursor
(Folylpoly-gamma-glutamate synthetase) (FPGS)
(Tetrahydrofolate synthase) (Tetrahydrofolylpolyglutamate
synthase); n=1; Tribolium castaneum|Rep: PREDICTED:
similar to Folylpolyglutamate synthase, mitochondrial
precursor (Folylpoly-gamma-glutamate synthetase) (FPGS)
(Tetrahydrofolate synthase) (Tetrahydrofolylpolyglutamate
synthase) - Tribolium castaneum
Length = 464
Score = 253 bits (619), Expect = 8e-66
Identities = 122/237 (51%), Positives = 164/237 (69%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y+ + LN LQ+N I+ K + L ++ YL R G+++ LD+LSV+HVA
Sbjct: 9 YDACIEALNNLQTNAQYIKT--KALTNNHNGDQLTQVKKYLYRAGLSLENLDDLSVIHVA 66
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
GTKGKG+T A E ILR HG++TGF+SSPHL+ VRER+R+NG+ IS+ F K F ++
Sbjct: 67 GTKGKGTTCAFTERILREHGYKTGFFSSPHLIEVRERIRINGKPISKPDFVKSFWKIYNA 126
Query: 672 LEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITA 851
L+ + E DMP +F FLT+MA+++FL+ KVDVAI+EVGIGG D TN+LRKVPVVGIT+
Sbjct: 127 LDQKKNDEHDMPLFFRFLTIMAFSVFLERKVDVAIIEVGIGGEYDCTNVLRKVPVVGITS 186
Query: 852 LGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXV 1022
LG+DH ++LG TI+ IA +KAGIMK C A+TV Q AM VL + + KC L V
Sbjct: 187 LGIDHVTLLGATIESIAWNKAGIMKENCRAFTVPQCQAAMTVLQERSIEKKCQLEIV 243
>UniRef50_Q5TSB4 Cluster: ENSANGP00000026850; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000026850 - Anopheles gambiae
str. PEST
Length = 490
Score = 252 bits (618), Expect = 1e-65
Identities = 123/240 (51%), Positives = 169/240 (70%), Gaps = 2/240 (0%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQ--IRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVH 485
YE A+ LN LQSN S ++ +RK + ++ D YL R GV+M L++L V+H
Sbjct: 14 YENAISSLNSLQSNSSVLQDSILRKHSEDNK---HINDTLKYLLRIGVSMDHLNQLPVIH 70
Query: 486 VAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVH 665
V+GTKGKGST AM ESILR +G+RTGF+SSPHLV+V+ERVRLNG +S D F YF ++
Sbjct: 71 VSGTKGKGSTCAMIESILRSNGYRTGFFSSPHLVSVKERVRLNGMPLSSDKFRLYFWKIY 130
Query: 666 QRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGI 845
++L ++ DMP YF FLT++A ++FL+E VDV ++EVGIGG D TN+L K VGI
Sbjct: 131 KQLLAYREHSRDMPSYFCFLTILALDVFLRESVDVCVIEVGIGGRYDCTNVLPKTGTVGI 190
Query: 846 TALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXVP 1025
T+LGL+HT +LGNT++EIA KAGI+KRG + ++V QP+E M+++ + LK L VP
Sbjct: 191 TSLGLEHTKLLGNTLEEIAWQKAGIIKRGSDVFSVVQPSECMEIIREECRKLKANLFVVP 250
>UniRef50_Q5JU23 Cluster: Folylpolyglutamate synthase; n=2; Homo
sapiens|Rep: Folylpolyglutamate synthase - Homo sapiens
(Human)
Length = 375
Score = 250 bits (613), Expect = 4e-65
Identities = 121/231 (52%), Positives = 168/231 (72%), Gaps = 1/231 (0%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y+ AVR LN LQ+N +EQ+++ + G T LE ME YL+R+G+ + LD L+++HV
Sbjct: 45 YQDAVRMLNTLQTNAGYLEQVKR--QRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVT 102
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
GTKGKGST A E ILR +G +TGF+SSPHLV VRER+R+NG+ IS ++F KYF ++ R
Sbjct: 103 GTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHR 162
Query: 672 LEDTQKFE-GDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGIT 848
LE+T+ MP YF FLT+MA+++FL+EKVD+A+VEVGIGG D TNI+RK V G++
Sbjct: 163 LEETKDGSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVS 222
Query: 849 ALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSL 1001
+LG+DHTS+LG+T+++IA K GI K+G A+TV QP + VL A +
Sbjct: 223 SLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQI 273
>UniRef50_Q9VYL1 Cluster: CG2543-PA; n=4; Sophophora|Rep: CG2543-PA -
Drosophila melanogaster (Fruit fly)
Length = 572
Score = 230 bits (562), Expect = 6e-59
Identities = 112/239 (46%), Positives = 162/239 (67%), Gaps = 1/239 (0%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
+E A+++LN LQSN + I + R K ++ YL R+G+ + +++LS +HVA
Sbjct: 96 FELAIKQLNSLQSNDAAIRNSMSNSRVDTKADTIK----YLERSGLPLETVEQLSFIHVA 151
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
GTKGKGST A+ ES+LRH GFRTGF+SSPH++ ER+R++G+++S+D F + F V+ R
Sbjct: 152 GTKGKGSTCALTESLLRHQGFRTGFFSSPHILFTNERIRIDGQLLSKDKFTEQFWKVYNR 211
Query: 672 LEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITA 851
L D ++ + DMP YF FLT++ +++F+ E VDV ++EVGIGG D TNI+R V VGIT+
Sbjct: 212 LWDLREHDHDMPAYFKFLTILGFHVFVAENVDVVVLEVGIGGEHDCTNIVRNVRTVGITS 271
Query: 852 LGLDHTSILGNTIQEIAASKAGIMKRGCEAYT-VQQPNEAMDVLIQYADSLKCPLTXVP 1025
LGL+HT +LG T+ EIA KAGI+K G +T V QP E ++V+ Q L VP
Sbjct: 272 LGLEHTELLGRTLPEIAWQKAGIIKTGSHVFTHVTQP-ECLEVIRQRTKEHSATLYEVP 329
>UniRef50_Q5KJZ3 Cluster: Tetrahydrofolylpolyglutamate synthase,
putative; n=2; Filobasidiella neoformans|Rep:
Tetrahydrofolylpolyglutamate synthase, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 497
Score = 219 bits (534), Expect = 1e-55
Identities = 124/246 (50%), Positives = 159/246 (64%), Gaps = 8/246 (3%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTN--LEDMENYLSRTGVTMSKLDELSVVH 485
Y AV LN QSN +TIE RK +G + T + +M +YL R G L+ L+VVH
Sbjct: 16 YAEAVSLLNTCQSNAATIEAFRK---SGGRLTEYAVAEMHDYLRRIGYKPEDLNALNVVH 72
Query: 486 VAGTKGKGSTSAMCESILRHH--GFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+ GTKGKGSTSA E ILR H G + G Y+SPHL AVRER+R+NG ISE FAKYF +
Sbjct: 73 ITGTKGKGSTSAFTERILRAHMPGKKVGLYTSPHLCAVRERIRINGEPISETEFAKYFFE 132
Query: 660 VHQRLE-DTQKFEGDMPK---YFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
V RLE D++ PK YF LT++A++ FL + V ++EVGIGGL D TNI+ K
Sbjct: 133 VWDRLEADSKPLTPQTPKFPVYFRLLTLLAFHAFLSQGVSATVLEVGIGGLYDSTNIVPK 192
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKC 1007
V GIT+LGLDHT++LGNTI+EIA +KAGI K+G A +V Q + DVL + A+ +
Sbjct: 193 PVVTGITSLGLDHTAVLGNTIEEIARNKAGIYKKGVPALSVVQ-EKGGDVLKEVAEMNEA 251
Query: 1008 PLTXVP 1025
P VP
Sbjct: 252 PFEIVP 257
>UniRef50_Q09509 Cluster: Putative folylpolyglutamate synthase; n=3;
Caenorhabditis elegans|Rep: Putative folylpolyglutamate
synthase - Caenorhabditis elegans
Length = 510
Score = 214 bits (522), Expect = 4e-54
Identities = 115/254 (45%), Positives = 155/254 (61%)
Frame = +3
Query: 264 CRSYLLNXITVRMCSYYEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRT 443
C + L + + YE +VR LN LQSN +TI+++R R + NL YL
Sbjct: 20 CGANQLRMSSEKAVPCYEESVRLLNGLQSNAATIKKLRVQ-RENLQAINLPQCRKYLESL 78
Query: 444 GVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRV 623
++ L+ L+++HV+GTKGKGS A ESILR G RTGFYSSPHLV VRER++++G+
Sbjct: 79 NISAEDLNALNIIHVSGTKGKGSACAFVESILRSQGLRTGFYSSPHLVHVRERIQVDGQP 138
Query: 624 ISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLV 803
+SE MFA+ F V+ ++ ++ +MP YF FLT++A+ IF+K V V I+EVGIGG
Sbjct: 139 VSEQMFAEEFFHVYDIIK--REHSDNMPAYFKFLTLLAFRIFVKLNVQVMILEVGIGGEY 196
Query: 804 DYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLI 983
D TN++ K V G+T L DH SILGN + EIA KAGI K A+ EA +VLI
Sbjct: 197 DCTNVVEKPKVCGVTTLDYDHMSILGNKLSEIAWHKAGIFKESVPAFYSPTTTEAEEVLI 256
Query: 984 QYADSLKCPLTXVP 1025
A S PL P
Sbjct: 257 ARAISKHVPLFQTP 270
>UniRef50_Q54CY5 Cluster: Tetrahydrofolylpolyglutamate synthase; n=1;
Dictyostelium discoideum AX4|Rep:
Tetrahydrofolylpolyglutamate synthase - Dictyostelium
discoideum AX4
Length = 626
Score = 208 bits (509), Expect = 2e-52
Identities = 110/242 (45%), Positives = 159/242 (65%), Gaps = 4/242 (1%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTN---LEDMENYLSRTGVTMSKLDELSVV 482
YE AV L LQSN++ I K+ R ++ + +E+M NY + L+ S++
Sbjct: 81 YEEAVNALLTLQSNQTVIISWTKERRDNKEESAKFLMEEMRNYCKTLSID---LERESII 137
Query: 483 HVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDV 662
HVAGTKGKGST A+ ESI+R GF TG ++SPHL++ RER+R+NG +IS++MF++YF +
Sbjct: 138 HVAGTKGKGSTCAITESIIREQGFSTGLFTSPHLISPRERIRINGEMISKEMFSQYFWNC 197
Query: 663 HQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVG 842
L + ++ +P +F +LT+MA IF E + I+EVGIGG +D TN+ K V G
Sbjct: 198 WDLL--IKDYQTQLPNFFRYLTLMALKIFQDEAIQCTILEVGIGGRMDSTNVFPKPMVTG 255
Query: 843 ITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTV-QQPNEAMDVLIQYADSLKCPLTX 1019
I+ALG DH ++LGNT+ EIA KAGIMK G +TV Q EA++VLI +++ +K PL+
Sbjct: 256 ISALGYDHQNLLGNTLAEIALEKAGIMKVGIPIFTVSSQLPEAINVLIDHSNKVKSPLSI 315
Query: 1020 VP 1025
VP
Sbjct: 316 VP 317
>UniRef50_O74742 Cluster: Probable folylpolyglutamate synthase; n=1;
Schizosaccharomyces pombe|Rep: Probable
folylpolyglutamate synthase - Schizosaccharomyces pombe
(Fission yeast)
Length = 505
Score = 208 bits (509), Expect = 2e-52
Identities = 112/231 (48%), Positives = 152/231 (65%), Gaps = 8/231 (3%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
+E A+ +LN LQSN +E +RK + + +E M ++L G S L+ L+V+HVA
Sbjct: 27 FEGAINRLNSLQSNAKVLEVLRKRGKIPNDQSMVE-MRHWLRCIGYQPSDLNRLNVIHVA 85
Query: 492 GTKGKGSTSAMCESILRH---HGFRT-----GFYSSPHLVAVRERVRLNGRVISEDMFAK 647
GTKGKGST A SIL+ G R+ G Y+SPHL +V ER++LNG+ IS+++F K
Sbjct: 86 GTKGKGSTCAFTSSILQQIQKSGERSIPKCIGMYTSPHLRSVCERIQLNGKPISQELFTK 145
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
YF DV +RLE+ + + P YF FLT+MA+++F+ E VD AI+EVGIGG D TN++ K
Sbjct: 146 YFFDVWERLENAVGSDSEKPMYFRFLTLMAWHVFISENVDAAIIEVGIGGEYDSTNLIEK 205
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
+T+LGLDHTS+LGNTI EIA KAGI K A T +Q EAM+VL
Sbjct: 206 PYATAVTSLGLDHTSLLGNTIAEIAWQKAGIYKESAIALTCEQAPEAMNVL 256
>UniRef50_Q8W038 Cluster: Folylpolyglutamate synthetase, mitochondrial
isoform; n=6; core eudicotyledons|Rep: Folylpolyglutamate
synthetase, mitochondrial isoform - Arabidopsis thaliana
(Mouse-ear cress)
Length = 625
Score = 202 bits (494), Expect = 1e-50
Identities = 111/239 (46%), Positives = 155/239 (64%)
Frame = +3
Query: 306 SYYEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVH 485
S Y+ A+ L+ L S ++ ++ T LE + YL + K+ EL V+H
Sbjct: 81 SSYDDAMEALSTLISRRNRGDRTP----TKGNRDKLEQVVTYLKILDLE-DKIKELKVIH 135
Query: 486 VAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVH 665
VAGTKGKGST E+ILR+ GFRTG ++SPHL+ VRER R++G ISE+ F +YF +
Sbjct: 136 VAGTKGKGSTCVFSEAILRNCGFRTGMFTSPHLIDVRERFRIDGLDISEEKFLQYFWECW 195
Query: 666 QRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGI 845
+ L++ MP F FLTV+A+ IF+ EKVDVA++EVG+GG +D TN+++K V GI
Sbjct: 196 KLLKEKAVDGLTMPPLFQFLTVLAFKIFVCEKVDVAVIEVGLGGKLDSTNVIQKPVVCGI 255
Query: 846 TALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXV 1022
+LG+DH ILGNT+ +IA KAGI K A+TV Q +EAMDVL + A++L+ PL V
Sbjct: 256 ASLGMDHMDILGNTLADIAFHKAGIFKPQIPAFTVPQLSEAMDVLQKTANNLEVPLEVV 314
>UniRef50_Q08645 Cluster: Folylpolyglutamate synthase; n=7;
Saccharomycetales|Rep: Folylpolyglutamate synthase -
Saccharomyces cerevisiae (Baker's yeast)
Length = 548
Score = 202 bits (493), Expect = 1e-50
Identities = 114/255 (44%), Positives = 157/255 (61%), Gaps = 12/255 (4%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y AV LN LQSN + I IR+ T LE M + R G + S ++L++VH+
Sbjct: 68 YRDAVTALNSLQSNYANIMAIRQTGDRKNTMTLLE-MHEWSRRIGYSASDFNKLNIVHIT 126
Query: 492 GTKGKGSTSAMCESILRHHGF---RTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDV 662
GTKGKGST+A SIL + R G Y+SPHL +VRER+R+NG ISE+ FAKYF +V
Sbjct: 127 GTKGKGSTAAFTSSILGQYKEQLPRIGLYTSPHLKSVRERIRINGEPISEEKFAKYFFEV 186
Query: 663 HQRLEDT----QKFE----GDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNI 818
RL+ T KF G P YF FLT+++++ F++E + EVG+GG +D TNI
Sbjct: 187 WDRLDSTTSSLDKFPHMIPGSKPGYFKFLTLLSFHTFIQEDCKSCVYEVGVGGELDSTNI 246
Query: 819 LRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQ-QPNEAMDVLIQYAD 995
+ K V G+T LG+DHT +LG+TI+EIA +K GI K G A+TV+ QP + + +L + A+
Sbjct: 247 IEKPIVCGVTLLGIDHTFMLGDTIEEIAWNKGGIFKSGAPAFTVEKQPPQGLTILKERAE 306
Query: 996 SLKCPLTXVPXYXLL 1040
K LT VP + L
Sbjct: 307 ERKTTLTEVPPFKQL 321
>UniRef50_Q16KT7 Cluster: Folylpolyglutamate synthase; n=1; Aedes
aegypti|Rep: Folylpolyglutamate synthase - Aedes aegypti
(Yellowfever mosquito)
Length = 415
Score = 201 bits (490), Expect = 3e-50
Identities = 93/179 (51%), Positives = 127/179 (70%)
Frame = +3
Query: 495 TKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRL 674
+K GST ++ ESILR HG+RTGF+SSPHLV+V ER+RLNG I FA YF ++ RL
Sbjct: 3 SKQNGSTCSLVESILRAHGYRTGFFSSPHLVSVTERIRLNGTPIDSTKFATYFWRIYNRL 62
Query: 675 EDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITAL 854
+++ D+P YF FLT++A+N+FL+EK+DVAIVEVGIGG D TN++R VGIT+L
Sbjct: 63 LNSRDHPYDLPAYFNFLTILAFNVFLREKIDVAIVEVGIGGKYDCTNVVRGTKTVGITSL 122
Query: 855 GLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXVPXY 1031
GL+HT++LGNTI++IA KAGI+K + +TV+QP +DV+ L VP +
Sbjct: 123 GLEHTALLGNTIEDIAWQKAGIIKNNSDVFTVRQPEGCLDVIANQCQEKAAQLHLVPDF 181
>UniRef50_Q4P7Z1 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 553
Score = 200 bits (487), Expect = 7e-50
Identities = 112/244 (45%), Positives = 156/244 (63%), Gaps = 14/244 (5%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTN--LEDMENYLSRTGVTMSKLDELSVVH 485
Y+ A+ LN LQSN +TIE +RK +G + + + +M YL R G T S L+ L+V+H
Sbjct: 18 YDDAIDALNSLQSNAATIEALRK---SGGRLLDFAIPEMVEYLERIGYTTSDLNRLNVIH 74
Query: 486 VAGTKGKGSTSAMCESILRH-------HGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
+ GTKGKGST A +S+L + G Y+SPH+ +VRER+R+NG+ ++ ++F
Sbjct: 75 ITGTKGKGSTCAFVDSLLGQLTPVNASAKPKVGLYTSPHMTSVRERIRINGQPVTHELFT 134
Query: 645 KYFHDVHQRLED--TQKFEGD--MPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYT 812
KYF V RL + T+KF+ P YF FLT++A++IFL E V I+EVGIGG D T
Sbjct: 135 KYFWQVWDRLSENPTRKFDLTPLRPVYFRFLTLLAFHIFLSEGVQPVILEVGIGGKYDST 194
Query: 813 NILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYT-VQQPNEAMDVLIQY 989
NI+ K V GIT LGLDHT+ILGNT++EIA KAGI K A QQP +A++ + Q
Sbjct: 195 NIVPKCVVAGITQLGLDHTAILGNTVEEIAVQKAGIFKPQAPAVCWAQQPGKALEQVKQV 254
Query: 990 ADSL 1001
A+ +
Sbjct: 255 ANQV 258
>UniRef50_Q2UUH9 Cluster: Folylpolyglutamate synthase; n=2;
Eurotiomycetidae|Rep: Folylpolyglutamate synthase -
Aspergillus oryzae
Length = 522
Score = 199 bits (485), Expect = 1e-49
Identities = 116/248 (46%), Positives = 150/248 (60%), Gaps = 11/248 (4%)
Frame = +3
Query: 312 YEXAVRKLNRLQSN-KSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHV 488
Y AV KLN QS K+ +E RTG LE M+ ++ R G S D L++VHV
Sbjct: 37 YHDAVEKLNSTQSGYKALLEGKGLGRRTGVPL--LEQMQQWVRRVGYETSDFDRLNIVHV 94
Query: 489 AGTKGKGSTSAMCESIL----RHHGF--RTGFYSSPHLVAVRERVRLNGRVISEDMFAKY 650
AGTKGKGST A SIL R G + G Y+SPHLV VRER+++N ISE+ F KY
Sbjct: 95 AGTKGKGSTCAFVNSILQCYNRSIGLPRKVGLYTSPHLVTVRERIQINSEPISEEKFTKY 154
Query: 651 FHDVHQRLEDTQKFEG-D---MPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNI 818
F +V LE + EG D P YF FLT+M++++F++E VD A+ EVG+GG D TN+
Sbjct: 155 FFEVWDALESSALREGLDPALKPSYFRFLTLMSFHVFMREGVDAAVYEVGVGGENDSTNV 214
Query: 819 LRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADS 998
+ + V GIT LGLDH LG+T+ +IA KAGI K C A+TV+Q +AM+VL Q A
Sbjct: 215 IVQPAVTGITTLGLDHVKRLGDTVDKIAWHKAGIFKNQCPAFTVEQVPDAMEVLEQRASE 274
Query: 999 LKCPLTXV 1022
L V
Sbjct: 275 KGAELATV 282
>UniRef50_O13492 Cluster: Folylpolyglutamate synthase; n=5;
Pezizomycotina|Rep: Folylpolyglutamate synthase -
Neurospora crassa
Length = 528
Score = 198 bits (482), Expect = 3e-49
Identities = 112/235 (47%), Positives = 154/235 (65%), Gaps = 12/235 (5%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRK-DIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHV 488
Y A+ LN LQ+ + IE RK IR ++++M YL+R G + LD L++VHV
Sbjct: 42 YNDAIDALNSLQTPFAVIEARRKAGIRPDAH--SVKEMRAYLARIGYSSQDLDRLNIVHV 99
Query: 489 AGTKGKGSTSAMCESIL-RH---HGF--RTGFYSSPHLVAVRERVRLNGRVISEDMFAKY 650
AGTKGKG T A +SIL RH HG R G ++SPHL+AVRER+R++ + ISE++FA+Y
Sbjct: 100 AGTKGKGGTCAFVDSILTRHQRTHGIPRRIGLFTSPHLIAVRERIRIDSKPISEELFARY 159
Query: 651 FHDVHQRLEDTQ--KFE---GDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTN 815
F +V RLE +Q K E G P Y +LT+M+Y+++L E VDVAI E GIGG D TN
Sbjct: 160 FFEVWDRLETSQLAKDEVELGSKPIYARYLTLMSYHVYLSEGVDVAIYETGIGGEYDATN 219
Query: 816 ILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
++ + V GI+ LG+DH +LG+T+ +IA KAGIMK G A+T++Q A VL
Sbjct: 220 VVDRPVVSGISTLGIDHVFVLGDTVDKIAWHKAGIMKTGSPAFTIEQVPSATQVL 274
>UniRef50_Q8W040 Cluster: Folylpolyglutamate synthetase, chloroplastic
isoform; n=5; Magnoliophyta|Rep: Folylpolyglutamate
synthetase, chloroplastic isoform - Arabidopsis thaliana
(Mouse-ear cress)
Length = 571
Score = 193 bits (471), Expect = 6e-48
Identities = 108/237 (45%), Positives = 148/237 (62%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
YE A+ L+ L + +S ++ K R E + +YL + L +++V+HVA
Sbjct: 67 YEEALAALSSLITKRSRADKSNKGDR-------FELVFDYLKLLDLEEDIL-KMNVIHVA 118
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
GTKGKGST ESI+R++GFRTG ++SPHL+ VRER RL+G ISE+ F YF + R
Sbjct: 119 GTKGKGSTCTFTESIIRNYGFRTGLFTSPHLIDVRERFRLDGVDISEEKFLGYFWWCYNR 178
Query: 672 LEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITA 851
L++ E MP YF FL ++A+ IF E+VD AI+EVG+GG D TN + K V GI++
Sbjct: 179 LKERTNEEIPMPTYFRFLALLAFKIFAAEEVDAAILEVGLGGKFDATNAVHKPVVCGISS 238
Query: 852 LGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXV 1022
LG DH ILG+T+ +IA KAGI K G A+TV QP+EAM VL + A + L V
Sbjct: 239 LGYDHMEILGDTLGKIAGEKAGIFKLGVPAFTVPQPDEAMRVLEEKASETEVNLEVV 295
>UniRef50_Q9M059 Cluster: Tetrahydrofolylpolyglutamate synthase-like
protein; n=9; Magnoliophyta|Rep:
Tetrahydrofolylpolyglutamate synthase-like protein -
Arabidopsis thaliana (Mouse-ear cress)
Length = 498
Score = 191 bits (466), Expect = 3e-47
Identities = 97/187 (51%), Positives = 125/187 (66%)
Frame = +3
Query: 462 LDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMF 641
+ ++ ++HVAGTKGKGST ESILR +G RTG ++SPHL+ VRER RLNG IS++ F
Sbjct: 55 VSQMKIIHVAGTKGKGSTCTFAESILRCYGLRTGLFTSPHLIDVRERFRLNGIEISQEKF 114
Query: 642 AKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNIL 821
YF +L++ E MP YF FL ++A+ IF E+VDV I+EVG+GG D TN+
Sbjct: 115 VNYFWCCFHKLKEKTSNEVPMPTYFCFLALLAFKIFTTEQVDVVILEVGLGGRFDATNV- 173
Query: 822 RKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSL 1001
K V GI++LG DH ILG T+ EIAA KAGI K G A+TV QP+EAM VL + A L
Sbjct: 174 -KPVVCGISSLGYDHMEILGYTLAEIAAEKAGIFKSGVPAFTVAQPDEAMRVLNEKASKL 232
Query: 1002 KCPLTXV 1022
+ L V
Sbjct: 233 EVNLQVV 239
>UniRef50_Q9Y893 Cluster: Folylpolyglutamate synthase; n=7;
Saccharomycetales|Rep: Folylpolyglutamate synthase -
Candida albicans (Yeast)
Length = 514
Score = 186 bits (452), Expect = 1e-45
Identities = 94/227 (41%), Positives = 143/227 (62%), Gaps = 12/227 (5%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRK-DIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHV 488
Y+ A+ LN LQSN ++IE +K + ++ ++ + R G T + ++L+++H+
Sbjct: 18 YKDAINALNSLQSNFASIEATKKLGPSVNRNELSINEVHEFTKRLGYTPTDFNKLNIIHI 77
Query: 489 AGTKGKGSTSAMCESILRHHGF-RTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVH 665
GTKGKGST A ESIL+ + + G Y+SPHL +VRER+R+NG+ I+++ FAKYF +V
Sbjct: 78 TGTKGKGSTCAFTESILKQYTISKIGLYTSPHLKSVRERIRINGQPINQEKFAKYFFEVW 137
Query: 666 QRLEDT----------QKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTN 815
+ T Q + P YF +LT++++++FL+E VD AI EVG+GG D TN
Sbjct: 138 DKFTTTKSDPQECPTLQPCDQVKPMYFKYLTILSFHVFLQEGVDTAIYEVGVGGTYDSTN 197
Query: 816 ILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQ 956
I+ K V GI+ALG+DHT +LGN I I +K GI K+G A+ +Q
Sbjct: 198 IIDKPTVTGISALGIDHTFMLGNNIASITENKTGIFKKGVPAFVSRQ 244
>UniRef50_Q2UGP7 Cluster: Folylpolyglutamate synthase; n=10;
Pezizomycotina|Rep: Folylpolyglutamate synthase -
Aspergillus oryzae
Length = 561
Score = 184 bits (448), Expect = 4e-45
Identities = 105/264 (39%), Positives = 151/264 (57%), Gaps = 22/264 (8%)
Frame = +3
Query: 297 RMCSYYEXAVRKLNRLQSNKSTIEQIRKD-IRTGQKCTNLEDMENYLSRTGVTMSKLDEL 473
RM YE A+ LN LQ+N + ++Q+R+ R +L + +L R G S L+ L
Sbjct: 41 RMSRNYEAAITALNSLQTNFAVVQQLRESGDRRQMNLRSLPETIEWLRRIGYQPSDLNRL 100
Query: 474 SVVHVAGTKGKGSTSAMCESILRHHGF--------------RTGFYSSPHLVAVRERVRL 611
+ VHVAGTKGKGSTSA SIL + + G Y+SPHL RER+++
Sbjct: 101 NPVHVAGTKGKGSTSAFISSILSQYTSPVPSESNDSAPRLKKVGLYTSPHLRFARERIQI 160
Query: 612 NGRVISEDMFAKYFHDVHQRLEDTQKFEGD-------MPKYFAFLTVMAYNIFLKEKVDV 770
NG +SE+ FA+YF +V RL++ + G+ P+YF +LT+MA++ +L E VD
Sbjct: 161 NGAPLSEEKFARYFFEVWDRLDEAARVAGENPEELRTKPQYFRYLTLMAFHTYLSEGVDA 220
Query: 771 AIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTV 950
A++E GIGG D TN+L + IT+LG+DHT++LG TI+EIA K GI+K G + ++
Sbjct: 221 AVIECGIGGEYDCTNVLERPAATAITSLGIDHTAMLGTTIEEIAWHKGGIIKPGVKGFSA 280
Query: 951 QQPNEAMDVLIQYADSLKCPLTXV 1022
Q A VL A K L +
Sbjct: 281 PQAASAERVLYDRAADKKTQLEII 304
>UniRef50_UPI0000E484D2 Cluster: PREDICTED: similar to
Folylpolyglutamate synthase; n=4; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to Folylpolyglutamate
synthase - Strongylocentrotus purpuratus
Length = 562
Score = 177 bits (431), Expect = 5e-43
Identities = 99/234 (42%), Positives = 139/234 (59%), Gaps = 4/234 (1%)
Frame = +3
Query: 336 NRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGST 515
N Q N+ ++++RK + + D L R G+T LD LS +HVAGTKGKGST
Sbjct: 38 NDRQENRPDLDELRKFL--------ISDYRICLERLGITRKDLDALSCIHVAGTKGKGST 89
Query: 516 SAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFE 695
AM E ILR +G++TG SSP L+ +RERVR+NG +S M+ +Y + + LE +
Sbjct: 90 CAMTERILRTYGYKTGIISSPPLLEIRERVRINGAPVSRAMYGRYGVECLELLEKNKTKF 149
Query: 696 GDM----PKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLD 863
G + ++ T +AY I +KEKVDVA+VEVG+GG D TN+L V G+++L ++
Sbjct: 150 GHIFTPVTGPYSMFTFIAYYILVKEKVDVAVVEVGLGGEYDSTNVLWSPTVTGVSSLAVE 209
Query: 864 HTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXVP 1025
H S LG+T+ +I+ K+GI K G A T Q EAM VL+Q A PL P
Sbjct: 210 HVSQLGDTLAKISWHKSGIFKDGRPALTAPQREEAMTVLVQRAKERNAPLRVCP 263
>UniRef50_A4S2I3 Cluster: Predicted protein; n=2; Ostreococcus|Rep:
Predicted protein - Ostreococcus lucimarinus CCE9901
Length = 486
Score = 171 bits (417), Expect = 2e-41
Identities = 98/234 (41%), Positives = 135/234 (57%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y+ AVR+L + + K R D +E Y+SR + ++D L VVHVA
Sbjct: 8 YDAAVRELAKTITGKK-----RADPGAVTWEAQFAQLETYVSRLDLR-GRVDALDVVHVA 61
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
GTKGKGST AM E +LR G R G ++SPHL+ VRER R++G ++ E+ FA+ F
Sbjct: 62 GTKGKGSTCAMVEGMLRASGTRVGTFTSPHLMDVRERFRIDGAMVDEETFAREFWWTRDA 121
Query: 672 LEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITA 851
+ G MP YF FLT++ IF V+ ++EVG+GG +D TN++R GIT+
Sbjct: 122 IAARCGDLG-MPAYFRFLTLLGLRIFSSAGVEACVLEVGLGGRLDATNVVRAPAACGITS 180
Query: 852 LGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
LG+DH ILG+T+ +IA KAGIMK G +T Q EAM L + A + PL
Sbjct: 181 LGMDHVDILGDTLGKIATEKAGIMKPGVRTFTAPQKPEAMVALERRAAEVGSPL 234
>UniRef50_A7PIN0 Cluster: Chromosome chr13 scaffold_17, whole genome
shotgun sequence; n=1; Vitis vinifera|Rep: Chromosome
chr13 scaffold_17, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 832
Score = 170 bits (413), Expect = 7e-41
Identities = 93/193 (48%), Positives = 123/193 (63%), Gaps = 5/193 (2%)
Frame = +3
Query: 462 LDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMF 641
+ ++ ++HVAGTKGKGST ESILR+ GFRTG ++SPHL+ VRER RL+G I E+ F
Sbjct: 372 ISKMKIIHVAGTKGKGSTCTFTESILRNCGFRTGLFTSPHLIDVRERFRLDGVEICEEKF 431
Query: 642 AKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKE-----KVDVAIVEVGIGGLVD 806
YF RL+ E D+ K +T + + I + +VDV I+EVG+GG +D
Sbjct: 432 LAYFWWCWDRLKVMN--EEDIDK--TSITKLEWRILINSDSIWLRVDVVILEVGLGGRLD 487
Query: 807 YTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQ 986
TN++++ V GIT+LG DH ILG+T+ EIA KAGI KRG A+TV QP EAM VL
Sbjct: 488 ATNVVQEPIVCGITSLGYDHMEILGHTLGEIAGEKAGIFKRGVPAFTVPQPEEAMCVLEA 547
Query: 987 YADSLKCPLTXVP 1025
A L PL +P
Sbjct: 548 KASQLDVPLQVIP 560
>UniRef50_A6R4T6 Cluster: Putative uncharacterized protein; n=2;
Ajellomyces capsulatus NAm1|Rep: Putative
uncharacterized protein - Ajellomyces capsulatus NAm1
Length = 452
Score = 163 bits (397), Expect = 6e-39
Identities = 88/234 (37%), Positives = 135/234 (57%), Gaps = 6/234 (2%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
YE A+ +LN + I + D G +DM +L G + + L+V+H+A
Sbjct: 5 YEGAIHRLN----TRRAIAKPNLDDMRGS-----DDMVEWLRLLGHSTGNMSRLNVIHIA 55
Query: 492 GTKGKGSTSAMCESILRHHGFRTGF------YSSPHLVAVRERVRLNGRVISEDMFAKYF 653
GTKGKGST A S+L+ HG +G+ Y+SPH+ +RER+R+NG IS+D+F F
Sbjct: 56 GTKGKGSTCAFIASLLKAHGDDSGYPQKIGLYTSPHIKDIRERIRINGEPISKDLFTIRF 115
Query: 654 HDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
+V +L + D+P+Y L ++++++F+KEKVDVA+ E +GG D TNI++
Sbjct: 116 FEVWDKLPSKATDKLDIPRYLQLLALLSFHVFIKEKVDVAVYEAHLGGEFDATNIIKMPT 175
Query: 834 VVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYAD 995
V IT++ +DH ++LG TI+ IA K GI K G A + Q +VL + AD
Sbjct: 176 VTAITSIAMDHVNLLGPTIERIAWHKGGIFKSGSVALSAPQERAVAEVLQERAD 229
>UniRef50_A2QK88 Cluster: Contig An04c0360, complete genome; n=2;
Pezizomycotina|Rep: Contig An04c0360, complete genome -
Aspergillus niger
Length = 538
Score = 163 bits (396), Expect = 8e-39
Identities = 102/254 (40%), Positives = 144/254 (56%), Gaps = 14/254 (5%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y +RKLN L +N + Q++ I T + ++DM + G D L+ VH+A
Sbjct: 35 YNDTLRKLNTLNTNFA-YRQLQ--IETVDQNVFIQDMLRWCRAVGYKSPDFDPLNAVHIA 91
Query: 492 GTKGKGSTSAMCESIL-RHHGF-----RTGFYSSPHLVAVRERVRLNGR--------VIS 629
G+KGKGSTSA +IL + G + G Y+SPHL VRER+R++ +S
Sbjct: 92 GSKGKGSTSAFIFAILSEYQGHENPIKKLGLYTSPHLRTVRERIRISPSNDTPFHHTSLS 151
Query: 630 EDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDY 809
ED F +YF DV RL T++ P + FLT++A + FL+EKVD A+VEV +GG D
Sbjct: 152 EDQFVQYFCDVWGRLGLTEETAKSGPPFARFLTLLALHGFLQEKVDTAVVEVCLGGRHDS 211
Query: 810 TNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQY 989
TN+L + V IT+L L+HT +LGNTI++IA +K GI+K G T+ Q A L +
Sbjct: 212 TNVLHRPSVSAITSLALEHTDVLGNTIEDIAWAKGGIIKPGVPILTIPQAPGATATLQKI 271
Query: 990 ADSLKCPLTXVPXY 1031
A PLT VP +
Sbjct: 272 AAEKGAPLTIVPVH 285
>UniRef50_A2QCB5 Cluster: Contig An02c0080, complete genome; n=6;
Trichocomaceae|Rep: Contig An02c0080, complete genome -
Aspergillus niger
Length = 489
Score = 156 bits (379), Expect = 9e-37
Identities = 84/215 (39%), Positives = 123/215 (57%), Gaps = 10/215 (4%)
Frame = +3
Query: 408 NLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGF------Y 569
+L M +L G + + + L++VHV GTKGKGST SIL HG RTGF Y
Sbjct: 46 SLHGMSEWLQILGHSETDVSRLNIVHVTGTKGKGSTCEFTRSILHAHGLRTGFPSKIGLY 105
Query: 570 SSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDM----PKYFAFLTVMA 737
+SPH+ +RER+++N + + +++F KYF +V L D + D P+Y FL ++A
Sbjct: 106 TSPHIQCIRERIQINNKPVPKNLFTKYFFEVWDTLMDPKAQNTDPKQQPPRYLQFLALLA 165
Query: 738 YNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAG 917
++ F++E VD AI EV G D TN+++ V GIT++GLDH + LG T++ IA K+G
Sbjct: 166 FHTFIRENVDAAIFEVHHGSEFDATNVIQNPVVTGITSIGLDHVTQLGPTVESIAWHKSG 225
Query: 918 IMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXV 1022
I K A +V Q + +VL A LT V
Sbjct: 226 IFKSSAPALSVPQEDRPTEVLHARAAEKNTSLTIV 260
>UniRef50_Q9VQW0 Cluster: CG31773-PA; n=1; Drosophila
melanogaster|Rep: CG31773-PA - Drosophila melanogaster
(Fruit fly)
Length = 758
Score = 155 bits (376), Expect = 2e-36
Identities = 89/240 (37%), Positives = 132/240 (55%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVA 491
Y A+++LN Q + T + ++ +E L ++G+T L + V+ VA
Sbjct: 276 YLDAIKQLNSYQVLEPTSGRATTKSSRKEQDPVIEQTLECLEKSGLTKKDLKAIPVIQVA 335
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
G+KG+GST A+ ESILR HG +TG SSPHL ER+R++G +S+ F + F ++
Sbjct: 336 GSKGRGSTCAIVESILRCHGVKTGVLSSPHLFLTSERIRIDGEPLSDVQFTELFWKINTD 395
Query: 672 LEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITA 851
L + Q P Y +TVMA++ F + V+VAI+EVG G D TNI +GIT
Sbjct: 396 LANMQP----TPSYNKIMTVMAFHAFHQAGVEVAILEVGNAGASDATNIASHAQTIGITT 451
Query: 852 LGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXVPXY 1031
LG + +S LGN++++IA +KA IMK YT E +VL Q A + L VP +
Sbjct: 452 LGWEQSSNLGNSLRDIAWAKASIMKPEANIYTNVTQTECCEVLAQKAKQIGAQLRRVPTF 511
>UniRef50_A6SID8 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 515
Score = 155 bits (375), Expect = 3e-36
Identities = 97/255 (38%), Positives = 136/255 (53%), Gaps = 32/255 (12%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDE--LSVVH 485
Y+ A+ L+ LQSN++ + I + + +M + + G L +H
Sbjct: 8 YQDAIALLDTLQSNRTIVSSISSTSKD-MNLYAIPEMLEWTRKAGYETKDFSSRGLKCIH 66
Query: 486 VAGTKGKGSTSAMCESILRHHGF------------------RTGFYSSPHLVAVRERVRL 611
VAGTKGKGS AM ++ILR + + G Y+SPHL++VRER+R+
Sbjct: 67 VAGTKGKGSVCAMIDNILRQYRSEESDIGVMPGGTERKALGKIGLYTSPHLMSVRERIRI 126
Query: 612 NGRVISEDMFAKYFHDVHQRLEDTQKFEGD----------MPKYFAFLTVMAYNIFLKEK 761
+G ISE +FA+YF ++ R D P YF +LT+MA + F++E
Sbjct: 127 DGLPISEPLFARYFFELWDRFSDAASASATPHPNPTSPETKPGYFRYLTIMALHTFMEEG 186
Query: 762 VDVAIVEVGIGGLVDYTNIL--RKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGC 935
V+ AI+E GIGG D TNIL V IT LG+DH +LGNTI +IA KAGIMK+G
Sbjct: 187 VETAIMECGIGGEYDSTNILPAEAVTATAITKLGIDHVGMLGNTIDKIAWHKAGIMKQGI 246
Query: 936 EAYTVQQPNEAMDVL 980
++TV Q EA VL
Sbjct: 247 PSFTVPQLQEAQSVL 261
>UniRef50_UPI0000587E85 Cluster: PREDICTED: similar to
Folylpolyglutamate synthase; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to Folylpolyglutamate
synthase - Strongylocentrotus purpuratus
Length = 520
Score = 154 bits (373), Expect = 5e-36
Identities = 81/177 (45%), Positives = 111/177 (62%), Gaps = 6/177 (3%)
Frame = +3
Query: 414 EDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAV 593
+D+ +L R G+ LD LS++HV GTKGKGST A E+IL G++TG SSP L+ +
Sbjct: 42 QDVLIFLERVGIGRDVLDGLSIIHVTGTKGKGSTCAFVENILETCGYKTGLLSSPSLIEI 101
Query: 594 RERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGD------MPKYFAFLTVMAYNIFLK 755
RER+R+ G + FA+Y + Q+LED GD P + +LTV++ +IFLK
Sbjct: 102 RERIRIGGTYLPRRKFAEYGLTILQKLEDAGN-SGDEQTTYRQPNFIQYLTVLSMHIFLK 160
Query: 756 EKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
EKVDV IVEV IGG D TNI + VGIT L LDH LG++++ IA K+G+ +
Sbjct: 161 EKVDVGIVEVFIGGETDCTNIFKTPSCVGITTLDLDHRDKLGDSLESIAWHKSGLAR 217
>UniRef50_Q4Q1G0 Cluster: Folylpolyglutamate synthetase; n=6;
Trypanosomatidae|Rep: Folylpolyglutamate synthetase -
Leishmania major
Length = 537
Score = 153 bits (371), Expect = 8e-36
Identities = 92/238 (38%), Positives = 139/238 (58%), Gaps = 13/238 (5%)
Frame = +3
Query: 339 RLQSNKSTIEQI-RKDIRTGQKCTN-LEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGS 512
R +S K +E + R R +C + E + ++ R G L+ + VHVAGTKGKG+
Sbjct: 59 RHRSFKDAMEVVERMTGRRPNRCPDGFETTKRFIDRLGFAPI-LERIRFVHVAGTKGKGT 117
Query: 513 TSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKF 692
TSA ++L+ +GF+ G ++SPHL +RER ++GR++ E+ +A+YF D + E Q
Sbjct: 118 TSAYTAALLQAYGFKVGLFTSPHLTDLRERTVVDGRLLDENAYAQYFFDFLDKYEALQYS 177
Query: 693 EGDMPK---------YFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGI 845
+ + + +F F+ +++ IF +E V VA++EVGIGG +D TN + V I
Sbjct: 178 DSQLDRDIASPSRANFFRFIFLLSLYIFEQEGVGVAVMEVGIGGRIDSTNTIPS-EVSII 236
Query: 846 TALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPN--EAMDVLIQYADSLKCPL 1013
T+LG DH ILGNTIQEIA+ KAGIMK G + Q + E VL ++A + PL
Sbjct: 237 TSLGYDHMDILGNTIQEIASEKAGIMKPGVVCFAAPQTDHPETRSVLEKHARKVGAPL 294
>UniRef50_A4RLF6 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 553
Score = 153 bits (371), Expect = 8e-36
Identities = 102/259 (39%), Positives = 140/259 (54%), Gaps = 33/259 (12%)
Frame = +3
Query: 315 EXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAG 494
+ A+ LN LQ+ + Q R + + +M + L+R G + LD L++VHVAG
Sbjct: 40 QDAIDLLNTLQT-PFKVFQARVAAGVRPDASFMTEMRSCLARIGHSPRDLDRLNIVHVAG 98
Query: 495 TKGKGSTSAMCESILRH----HGF--RTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
TKGKG+ A +SIL HG + G +SPHL++VRER+R+N +SED+FAKYF
Sbjct: 99 TKGKGTVCAYVDSILNRWRASHGVPGKLGLLTSPHLISVRERIRINSEPVSEDLFAKYFF 158
Query: 657 DVHQRLEDTQ---KFEG----------------------DMPKYFAFLTVMAYNIFLKEK 761
+V RLE EG P Y +LT+M++++FL E
Sbjct: 159 EVWDRLEQNPPQGSVEGVSNDGSGRKDDWLDHWSGGSYAGKPIYARYLTLMSWHLFLSEG 218
Query: 762 VDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEA 941
VD+A+ E GIGG D TN++ + IT LG+DH LG TI EIA KAGI+K G
Sbjct: 219 VDLAVYETGIGGEYDATNVVERPLATAITTLGIDHVHALGGTIGEIAWHKAGIIKSGSMN 278
Query: 942 YTVQQPN--EAMDVLIQYA 992
YTV+ EA DVL + A
Sbjct: 279 YTVRHETFPEAEDVLKERA 297
>UniRef50_Q8XJ43 Cluster: Folyl-polyglutamate synthetase; n=13;
Clostridium|Rep: Folyl-polyglutamate synthetase -
Clostridium perfringens
Length = 440
Score = 152 bits (368), Expect = 2e-35
Identities = 73/181 (40%), Positives = 113/181 (62%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+H+ GT GKGST+AM S+LR GF+ G Y+SP+L ER+++NG I++D A D
Sbjct: 42 IHIGGTNGKGSTTAMISSVLREAGFKVGMYTSPYLEEFEERIQINGENINKDDLAILMGD 101
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
V + ++ + + P F +T + + F K+KVD A++EVG+GG +D TN++ VV
Sbjct: 102 VKKAIDKVMELGYESPTQFEIITALMFYYFSKKKVDYAVLEVGLGGRLDATNVVLP-EVV 160
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTX 1019
+T++ LDH +ILGNTI+EIA K GI+K G + Q +A++V+ + + L C L
Sbjct: 161 VLTSISLDHMNILGNTIEEIAKEKCGIIKSGVPVISYPQEEKALEVIKERCNELGCNLEV 220
Query: 1020 V 1022
V
Sbjct: 221 V 221
>UniRef50_Q4THS1 Cluster: Chromosome undetermined SCAF2726, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF2726,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 171
Score = 151 bits (367), Expect = 3e-35
Identities = 82/173 (47%), Positives = 112/173 (64%), Gaps = 23/173 (13%)
Frame = +3
Query: 315 EXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMS------------ 458
+ AV LN LQ+N S +EQ+R++ L+ ME +L R G+T+S
Sbjct: 1 QDAVCTLNTLQTNASCLEQVRRE--RNHPRLQLQAMEGFLERAGLTVSGRGGGRPAGPHR 58
Query: 459 ----------KLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVR 608
+LD L+++HV GTKGKGST A E ILR HGFRTGFYSSPHLV VRER+R
Sbjct: 59 PADASLSKVEQLDHLNIIHVTGTKGKGSTCAFTEHILRSHGFRTGFYSSPHLVQVRERIR 118
Query: 609 LNGRVISEDMFAKYFHDVHQRLEDTQKFEGD-MPKYFAFLTVMAYNIFLKEKV 764
+NG+ IS+++F KYF V+ RLE+T+ G MP YF FLT++A+++FL+E+V
Sbjct: 119 INGKPISKELFTKYFWQVYGRLEETKVAHGGAMPAYFRFLTILAFHVFLQEEV 171
>UniRef50_UPI000023EDF3 Cluster: hypothetical protein FG00685.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG00685.1 - Gibberella zeae PH-1
Length = 364
Score = 147 bits (357), Expect = 4e-34
Identities = 78/190 (41%), Positives = 114/190 (60%), Gaps = 12/190 (6%)
Frame = +3
Query: 411 LEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVA 590
+ +M +L R G L L +H+AGTKGKGS SA +LR + G Y+SPHLV+
Sbjct: 55 IPEMREWLRRAGYEPKDLARLKHIHIAGTKGKGSVSAFATGMLRQYE-TVGTYTSPHLVS 113
Query: 591 VRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEG----------DMPKYFAFLTVMAY 740
RER+ + G +S+ +FA F ++ +RL D K EG P +F F+T++A+
Sbjct: 114 PRERIAIQGEQVSQALFADAFFELWERLSDAAKKEGQTITDANGPNSKPFFFRFMTLLAW 173
Query: 741 NIFLKEKVDVAIVEVGIGGLVDYTNI--LRKVPVVGITALGLDHTSILGNTIQEIAASKA 914
+IFL EKVD ++E GIGG D TN+ L V I+ LG+DH ++LGNT+++I+ KA
Sbjct: 174 HIFLSEKVDSVVLECGIGGEYDATNVVPLEAVSAAVISQLGIDHVAMLGNTVEKISWHKA 233
Query: 915 GIMKRGCEAY 944
GI+K G +
Sbjct: 234 GILKPGIRGF 243
>UniRef50_A7CTY2 Cluster: FolC bifunctional protein; n=1;
Opitutaceae bacterium TAV2|Rep: FolC bifunctional
protein - Opitutaceae bacterium TAV2
Length = 448
Score = 147 bits (357), Expect = 4e-34
Identities = 78/175 (44%), Positives = 111/175 (63%), Gaps = 1/175 (0%)
Frame = +3
Query: 471 LSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKY 650
+ V+HVAGT GKGS +AM ESILR G RTG Y+SPHL+ + ERV+++ ++E +Y
Sbjct: 45 MPVIHVAGTNGKGSVAAMIESILRAAGLRTGLYTSPHLIRLGERVQVDRVPLTEAEIVRY 104
Query: 651 FHDVHQRLEDTQKFEGD-MPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
++ E + MP +F F+T MA+ F + + DVAI+EVG+GG +D TNI+
Sbjct: 105 VEELRPVAERIGAASAEAMPSFFEFMTAMAFLQFSRRRCDVAIIEVGLGGRLDATNIVEP 164
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYA 992
V V IT++GLDH +LGNT++ IAA KAGI+K G + P A V+ + A
Sbjct: 165 VMSV-ITSIGLDHCEMLGNTLESIAAEKAGIIKPGVPVVLGRLPAAAERVVREIA 218
>UniRef50_A7EG57 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 520
Score = 147 bits (357), Expect = 4e-34
Identities = 98/269 (36%), Positives = 136/269 (50%), Gaps = 32/269 (11%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDE--LSVVH 485
Y+ A+ L+ LQSN++ + I K + +M + + G + L +H
Sbjct: 8 YDDAIALLDTLQSNRTIVSSISKTSED-MNMYAIPEMLEWTRKAGYETGDFSKRGLKCIH 66
Query: 486 VAGTKGKGSTSAMCESILRHH-----------------GF-RTGFYSSPHLVAVRERVRL 611
VAGTKGKGS AM +ILR + G + G Y+SPHL+ VRER+R+
Sbjct: 67 VAGTKGKGSVCAMIGNILRQYRRKENDVGVVPGDAKRKGLGKIGLYTSPHLMTVRERIRI 126
Query: 612 NGRVISEDMFAKYFHDVHQRLEDTQ----------KFEGDMPKYFAFLTVMAYNIFLKEK 761
+G ISE +FA+YF ++ R D P YF +LT+MA + F++E
Sbjct: 127 DGSPISERLFARYFFELWDRFSDASAASTAPHSNPTSSETKPGYFRYLTIMALHTFMEEG 186
Query: 762 VDVAIVEVGIGGLVDYTNIL--RKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGC 935
V+ AI+E GIGG D TNIL V IT LG+DH +LG+TI +IA KAGIMK+
Sbjct: 187 VETAIIECGIGGEYDSTNILPAEAVTTTAITKLGIDHVGVLGDTIDKIAWHKAGIMKKNI 246
Query: 936 EAYTVQQPNEAMDVLIQYADSLKCPLTXV 1022
+T Q A VL A + L V
Sbjct: 247 SCFTSPQLQTAQSVLENRAKEIGVKLEVV 275
>UniRef50_Q6A9I9 Cluster: Folylpolyglutamate synthase; n=1;
Propionibacterium acnes|Rep: Folylpolyglutamate synthase
- Propionibacterium acnes
Length = 481
Score = 147 bits (355), Expect = 7e-34
Identities = 82/191 (42%), Positives = 113/191 (59%), Gaps = 3/191 (1%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ +AGT GKGST+ M +S+LR G R G Y SPHLV V ER+ ++GR +S D+F + +
Sbjct: 43 VIQIAGTNGKGSTAIMVDSLLRSAGLRVGRYCSPHLVDVTERICIDGRPVSHDLFDETWR 102
Query: 657 DVHQR--LEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKV 830
V L D Q +G +F +T MA+ F VDVA+VEVG+GG D TN+
Sbjct: 103 QVEPMVGLVDAQHIDGIEMTFFEVMTAMAFAAFADAPVDVAVVEVGLGGRWDATNV-ADA 161
Query: 831 PVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLI-QYADSLKC 1007
+ +T + +DH ILG+++ +IAA KAGI+K GC Q EA VL+ Q AD+
Sbjct: 162 NIAVVTPVAMDHMHILGDSLDKIAAEKAGIIKPGCTPVIAGQEAEAAPVLLAQCADAGVK 221
Query: 1008 PLTXVPXYXLL 1040
PL P + LL
Sbjct: 222 PLLEGPDWGLL 232
>UniRef50_A3IEY2 Cluster: Folyl-polyglutamate synthetase; n=1;
Bacillus sp. B14905|Rep: Folyl-polyglutamate synthetase -
Bacillus sp. B14905
Length = 426
Score = 146 bits (354), Expect = 1e-33
Identities = 67/182 (36%), Positives = 117/182 (64%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
++L V+HVAG+ GKGST +L+H G + G ++SPHL V ER+ +NG I+++ F
Sbjct: 36 NKLRVIHVAGSNGKGSTVNALREMLQHTGHQVGAFTSPHLERVNERMTINGEPITDEQFL 95
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
YF+ + + +E +++ GD P +F +T++ + F +++D+A++E G+GG +D TN++
Sbjct: 96 YYFNKLAKIIE--EQYNGDFPSFFEVVTLIMFQFFADQEIDIALIETGLGGRLDATNVVT 153
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLK 1004
+ + IT + L+HT+ LG+T +IA+ KAGI+KRG EA+ V+ + AD+ +
Sbjct: 154 PLLAI-ITTISLEHTAFLGDTFAKIASEKAGIIKRGVPVVIGVSNEEALAVIKETADAQQ 212
Query: 1005 CP 1010
P
Sbjct: 213 AP 214
>UniRef50_Q01UR3 Cluster: FolC bifunctional protein; n=1; Solibacter
usitatus Ellin6076|Rep: FolC bifunctional protein -
Solibacter usitatus (strain Ellin6076)
Length = 422
Score = 144 bits (350), Expect = 3e-33
Identities = 81/181 (44%), Positives = 108/181 (59%), Gaps = 2/181 (1%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
+VHVAGT GKGST AM ES LR G TG ++SPHL ER+R+NG +S + F+ F
Sbjct: 43 IVHVAGTNGKGSTCAMIESGLRASGRSTGLFTSPHLAEPTERIRINGVPVSAERFSAAFD 102
Query: 657 DVHQRLEDTQKFEG-DM-PKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKV 830
VH +E D+ YF +T MA+ IF +E VD+ ++EVG+GG +D TN++
Sbjct: 103 RVHAAVEQLLAVNAIDLHTTYFETVTAMAFLIFAEEAVDIVVLEVGLGGRLDATNVVLPE 162
Query: 831 PVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCP 1010
V IT + DH + LG ++QEIA KAGI+K G A +Q EA VL Q A L P
Sbjct: 163 LCV-ITPVDFDHEAFLGRSLQEIAGEKAGILKAGVPAVFARQRAEASAVLDQRAAQLSIP 221
Query: 1011 L 1013
+
Sbjct: 222 I 222
>UniRef50_A6C8Q2 Cluster: Folyl-polyglutamate synthetase; n=1;
Planctomyces maris DSM 8797|Rep: Folyl-polyglutamate
synthetase - Planctomyces maris DSM 8797
Length = 477
Score = 143 bits (347), Expect = 7e-33
Identities = 74/184 (40%), Positives = 114/184 (61%), Gaps = 2/184 (1%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
E+ +H+AGTKGKGSTSAM +L GFRTG ++SPH+ ER+ ++GR I +
Sbjct: 52 EVRTIHIAGTKGKGSTSAMIAEMLSAAGFRTGLFTSPHITCYEERILIDGRQIEPEQLVD 111
Query: 648 YFHDVHQRLEDTQKFEGDM-PKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
++ Q +E G++ P +F T +A+ F +++VD A++EVG+GG +D TN+
Sbjct: 112 LVSELIQVVEQLDLKPGNLSPTFFELTTALAWMHFQQQRVDFAVMEVGLGGRLDSTNVCE 171
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYT-VQQPNEAMDVLIQYADSL 1001
+ V +T + DHT++LGNTI++I KAGI+K+G ++ V QP EAM VL +
Sbjct: 172 PLASV-VTNISYDHTALLGNTIEQITREKAGIIKQGVPVFSGVTQP-EAMAVLEEVCREK 229
Query: 1002 KCPL 1013
+ PL
Sbjct: 230 QAPL 233
>UniRef50_A6PUD4 Cluster: FolC bifunctional protein; n=1; Victivallis
vadensis ATCC BAA-548|Rep: FolC bifunctional protein -
Victivallis vadensis ATCC BAA-548
Length = 432
Score = 142 bits (345), Expect = 1e-32
Identities = 78/178 (43%), Positives = 104/178 (58%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
+L +H+AGT GKGST AM E LR GF TGFYSSPHL+ +RER R+NGR + + F
Sbjct: 38 DLKFIHLAGTNGKGSTGAMLECALRSAGFTTGFYSSPHLIDIRERFRVNGRAVPQGDFDA 97
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
Y ++ + + YF F TV+A IF + VDV I E G+GG +D TN++
Sbjct: 98 YAAELAEAARRNTGRDFRF-TYFEFTTVLAALIFARAGVDVVIWETGMGGRLDSTNVVNP 156
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSL 1001
+ V IT + LDH + LG+TI +IA KAGI+K + P EA VL+ A L
Sbjct: 157 IATV-ITNIALDHQAYLGDTIDKIAWEKAGIIKPAVPLFYGVMPEEARQVLLDRARQL 213
>UniRef50_Q38AL2 Cluster: Folylpolyglutamate-dihydrofolate synthetase,
putative; n=1; Trypanosoma brucei|Rep:
Folylpolyglutamate-dihydrofolate synthetase, putative -
Trypanosoma brucei
Length = 500
Score = 142 bits (345), Expect = 1e-32
Identities = 84/193 (43%), Positives = 112/193 (58%), Gaps = 9/193 (4%)
Frame = +3
Query: 462 LDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMF 641
LD L VHVAGTKGKG+T++ ++L +G + G ++SPH+ VRER+ +N V+ D F
Sbjct: 76 LDTLRFVHVAGTKGKGTTASYTAALLEAYGLKVGLFTSPHVKDVRERIMVNNEVLPMDTF 135
Query: 642 AKYFH---DVHQRLEDTQK-FEGDMP---KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGL 800
YF D L K D+P +F + +++ F E VDVA+VEVGIGG
Sbjct: 136 VHYFFQVVDCFVELAGADKEVTWDLPAPCSFFCLMFLVSLVAFAGESVDVAVVEVGIGGS 195
Query: 801 VDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPN--EAMD 974
D TNI+ V ITALG+DHT ILG+T++EIA KAGIMK G Y Q +
Sbjct: 196 RDPTNIIIPEASV-ITALGIDHTEILGDTVEEIALQKAGIMKPGVVCYAAPQGDHPSTRR 254
Query: 975 VLIQYADSLKCPL 1013
VL YA+ + PL
Sbjct: 255 VLKDYAEGVDSPL 267
>UniRef50_A5FMS8 Cluster: FolC bifunctional protein; n=14;
Bacteroidetes|Rep: FolC bifunctional protein -
Flavobacterium johnsoniae UW101
Length = 408
Score = 142 bits (344), Expect = 2e-32
Identities = 73/182 (40%), Positives = 108/182 (59%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
+L +HVAGT GKGSTS M S+L+ G++ G Y+SPHL RER+++NG+ I+ED +
Sbjct: 45 KLQTIHVAGTNGKGSTSHMLASVLQEAGYKVGLYTSPHLKDFRERIKINGQEITEDFVCE 104
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
+ + FE + +F +A++ F EK D+AI+EVG+GG +D TNI+
Sbjct: 105 FI------AKHKDFFEANDMSFFEMSVGLAFDYFAAEKTDIAIIEVGLGGRLDATNIITP 158
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKC 1007
+ V IT +GLDHT LGNT++ IA KAGI+K + E V + A++ K
Sbjct: 159 LVSV-ITNIGLDHTQFLGNTLEAIAGEKAGIIKPNVPVVIGEYTPETQPVFLAKAEANKA 217
Query: 1008 PL 1013
P+
Sbjct: 218 PI 219
>UniRef50_Q5C3N8 Cluster: SJCHGC04288 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC04288 protein - Schistosoma
japonicum (Blood fluke)
Length = 154
Score = 141 bits (342), Expect = 3e-32
Identities = 79/152 (51%), Positives = 98/152 (64%), Gaps = 3/152 (1%)
Frame = +3
Query: 522 MCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGD 701
M ESILR GF TGF SSPHL+ V ER+R++G+ IS D FA F DVH +L + K +
Sbjct: 1 MIESILRKSGFHTGFLSSPHLINVEERIRIDGQPISRDHFADVFWDVHGKLLEFTKISTN 60
Query: 702 --MPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSI 875
MP + ++ VMA F++ KVDV I EVGIGG D+TNI + V IT+L L+HT+I
Sbjct: 61 TTMPSFLHYIFVMACKAFVEMKVDVGIFEVGIGGRYDHTNIFKDPYVTIITSLALEHTNI 120
Query: 876 LGNTIQEIAASKAGIMKRGCEAYTVQ-QPNEA 968
LG+TI EIA KAGI K G A QP EA
Sbjct: 121 LGDTIGEIAWRKAGIFKPGSIAVVSHGQPYEA 152
>UniRef50_A2G107 Cluster: FolC bifunctional protein; n=1;
Trichomonas vaginalis G3|Rep: FolC bifunctional protein
- Trichomonas vaginalis G3
Length = 399
Score = 141 bits (342), Expect = 3e-32
Identities = 75/175 (42%), Positives = 105/175 (60%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
E+ + VAGTKGKGST A+ ESILRH G +TG ++SPHL RER+++NG IS D +
Sbjct: 43 EIPSIVVAGTKGKGSTCAVIESILRHSGLKTGLFTSPHLETPRERIKINGVSISGDEYIS 102
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
+H++ +L T F+ P +F T+M+ ++F K +D+A++E G+GG D+T I
Sbjct: 103 SYHNITSKL-STSGFK--QPPFFGLHTLMSIDVFEKHNIDIAVIECGVGGRFDWTKIYSP 159
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYA 992
+ V IT L DH LG T Q IA KAGI + A T Q MD L++ A
Sbjct: 160 LTSV-ITHLEYDHLETLGKTAQSIAWHKAGIFAKDIPALTAPQNKPFMDELVRCA 213
>UniRef50_Q97SN7 Cluster: Dihydrofolate synthetase; n=15;
Streptococcus|Rep: Dihydrofolate synthetase -
Streptococcus pneumoniae
Length = 440
Score = 140 bits (340), Expect = 5e-32
Identities = 80/208 (38%), Positives = 116/208 (55%)
Frame = +3
Query: 387 RTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGF 566
RT Q LE M L+ G KL V+H+ GT GKGST A + +L G R G
Sbjct: 14 RTDQPHFGLERMVELLALRGNPHLKL---KVLHIGGTNGKGSTIAFLKKMLEKLGLRVGV 70
Query: 567 YSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNI 746
+SSP+L+ +++ +NG ISE D LE F +T +AY+
Sbjct: 71 FSSPYLIHYTDQISINGESISEARLEALMADYQSLLEGEAVANLQGTTEFEIITALAYDY 130
Query: 747 FLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
F E+VDVAI+EVG+GGL+D TN+ + + + GIT +GLDH ++LG+T++ IA KAGI+K
Sbjct: 131 FASEQVDVAIMEVGMGGLLDSTNVCQPI-LTGITTIGLDHVALLGDTLEVIAEQKAGIIK 189
Query: 927 RGCEAYTVQQPNEAMDVLIQYADSLKCP 1010
+G T + EA+ V+ + A+ P
Sbjct: 190 QGMPLVTGRIAPEALAVIDRIAEGKDAP 217
>UniRef50_Q64S09 Cluster: Folylpolyglutamate synthase; n=2;
Bacteroides fragilis|Rep: Folylpolyglutamate synthase -
Bacteroides fragilis
Length = 458
Score = 140 bits (340), Expect = 5e-32
Identities = 72/179 (40%), Positives = 104/179 (58%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+H+AGT GKGS S +IL+ G+R G Y+SPHLV RER+R+NG I ++ ++ D
Sbjct: 49 IHIAGTNGKGSCSHTLAAILQSAGYRVGLYTSPHLVDFRERIRINGEPIPQEYVIRFVED 108
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
H+ FE P +F T MA+ F + +DVA++EVG+GG +D TNI+R +
Sbjct: 109 -HRLF-----FEPLHPSFFELTTAMAFRYFADQHIDVAVIEVGLGGRLDCTNIIRPDLSI 162
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLT 1016
IT + DH LGNT+ +IA KAGI+KRG + E V + A ++ P+T
Sbjct: 163 -ITNISFDHMQFLGNTLAQIATEKAGIIKRGIPVVVGETTEETKPVFYRKAQEMEAPVT 220
>UniRef50_Q1PZI3 Cluster: Similar to multifunctional
folylpolyglutamate synthase/dihydrofolate synthase; n=1;
Candidatus Kuenenia stuttgartiensis|Rep: Similar to
multifunctional folylpolyglutamate synthase/dihydrofolate
synthase - Candidatus Kuenenia stuttgartiensis
Length = 464
Score = 138 bits (334), Expect = 3e-31
Identities = 79/207 (38%), Positives = 125/207 (60%), Gaps = 5/207 (2%)
Frame = +3
Query: 408 NLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLV 587
NL+ M L + G + E S +H+ GTKGKGST+ M ++L+ G++TG ++SPHL
Sbjct: 43 NLDRMVRLLEQVG---NPHREFSSLHITGTKGKGSTAIMLSTVLQRAGYKTGLFTSPHLT 99
Query: 588 AVRERVRLNGRVISEDMFAKYFH----DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLK 755
++ER++LN I E+ F + D+ QRL +T E P +F LT + + F +
Sbjct: 100 NLKERIQLNHTKIPEEDFTAALNVLVPDI-QRLRNTTPAES--PTFFETLTAICFLYFKE 156
Query: 756 EKVDVAIVEVGIGGLVDYTNILRKVPVVG-ITALGLDHTSILGNTIQEIAASKAGIMKRG 932
++ ++A++EVG+GG +D TN++ +P+V IT +GLDH +ILGNTI IA KAGI+K+G
Sbjct: 157 KQAEMAVLEVGMGGRLDATNVV--LPLVSVITNIGLDHVNILGNTIPRIAYEKAGIIKKG 214
Query: 933 CEAYTVQQPNEAMDVLIQYADSLKCPL 1013
+ + EA+ V+ + PL
Sbjct: 215 IPVISAAEKPEALSVIKEVCMEKGAPL 241
>UniRef50_A6BCX0 Cluster: Putative uncharacterized protein; n=2;
Clostridiales|Rep: Putative uncharacterized protein -
Dorea longicatena DSM 13814
Length = 446
Score = 138 bits (334), Expect = 3e-31
Identities = 76/197 (38%), Positives = 112/197 (56%)
Frame = +3
Query: 411 LEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVA 590
LE + +L R G + + +VHVAGT GKGS A ++IL G RTGF++SPHLV+
Sbjct: 32 LEHTKTFLKRLG---NPAADRKIVHVAGTNGKGSVCAYLQAILMAEGKRTGFFTSPHLVS 88
Query: 591 VRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDV 770
V ER+R++ I + F K F V + + + + P YF FL M F + V+
Sbjct: 89 VNERIRVDNIQIDNETFLKVFRKVLKIVRQMVEDGIEHPSYFEFLFGMGMTAFAETDVEY 148
Query: 771 AIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTV 950
I+E G+GG +D TN + + IT++ LDHT+ILG+TI++IA KAGI+K G +
Sbjct: 149 IILETGLGGRLDATNAIDNPALAIITSISLDHTAILGDTIEKIAGEKAGIIKPGVPVFFD 208
Query: 951 QQPNEAMDVLIQYADSL 1001
+A +V+ A L
Sbjct: 209 GSSKKAAEVIKAKASEL 225
>UniRef50_Q2JLQ4 Cluster: Folylpolyglutamate synthase; n=2;
Synechococcus|Rep: Folylpolyglutamate synthase -
Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria
bacteriumYellowstone B-Prime)
Length = 433
Score = 138 bits (333), Expect = 3e-31
Identities = 81/205 (39%), Positives = 114/205 (55%)
Frame = +3
Query: 408 NLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLV 587
+LE M+ L R G + + +HVAGT GKGS A +L G+R G Y+SPHLV
Sbjct: 28 SLERMQVLLQRLGQPQAGIP---AIHVAGTNGKGSVCAWVSHVLWAAGYRVGRYTSPHLV 84
Query: 588 AVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVD 767
RER+ LNG IS + +++ V L+ E P F +T A+ F ++KVD
Sbjct: 85 DWRERIWLNGEYISANDWSQALAQVRDCLQTYAPDEAS-PTQFEVITAAAWLYFRRQKVD 143
Query: 768 VAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYT 947
VA++EVG+GG +D TN + V IT++G DH LGN++ +IA+ KAGI+K G A
Sbjct: 144 VAVIEVGLGGRLDATNAGIEPVVTAITSIGWDHWQRLGNSLPQIASEKAGILKPGIPAVC 203
Query: 948 VQQPNEAMDVLIQYADSLKCPLTXV 1022
Q E V+ A+ L+ PL V
Sbjct: 204 APQTPEVTAVIRAKAEQLRSPLRVV 228
>UniRef50_A4RKT0 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 510
Score = 138 bits (333), Expect = 3e-31
Identities = 84/220 (38%), Positives = 115/220 (52%), Gaps = 19/220 (8%)
Frame = +3
Query: 420 MENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHH----------------- 548
M +L+ G +K V+HV GTKGKG T A + +LR H
Sbjct: 40 MREWLTALGHDRTKTP-FDVIHVTGTKGKGGTCAWTDGLLRAHLKARAAGPRAAPGAQQN 98
Query: 549 -GFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRL-EDTQKFEGDMPKYFAF 722
+ G Y+SPH+V+ RER+R++ +SED F ++F +V L DMP Y
Sbjct: 99 QQLKVGLYTSPHIVSERERIRIDFAPVSEDTFTRHFFEVWDALLRHVGGGVDDMPGYLQL 158
Query: 723 LTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIA 902
L +++ IF KE V VAI EV GG D T++ + G +GLDH +LGN + EIA
Sbjct: 159 LALLSAQIFRKEGVAVAIYEVHAGGRFDATSLWDRPVACGFNTIGLDHVGLLGNNVSEIA 218
Query: 903 ASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXV 1022
+KAGIM+RG A +V Q EA + L+ A L CPL V
Sbjct: 219 WNKAGIMRRGTTAISVPQVPEAREQLVAEAKLLDCPLMFV 258
>UniRef50_A6LA17 Cluster: Folylpolyglutamate synthase; n=2;
Parabacteroides|Rep: Folylpolyglutamate synthase -
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701
/ NCTC11152)
Length = 439
Score = 137 bits (332), Expect = 4e-31
Identities = 74/178 (41%), Positives = 111/178 (62%), Gaps = 1/178 (0%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+HVAGT GKGS S + +ILR GF+ G Y+SPHLV RER+R+NG+ IS+D + F +
Sbjct: 49 IHVAGTNGKGSVSHLLAAILRQSGFKVGLYTSPHLVDFRERIRVNGKKISQD-YVVDFVE 107
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
H+ FE P +F + MA+ F ++V+ A++EVG+GG +D TNI+ + +
Sbjct: 108 RHRSF-----FEPLHPSFFELTSSMAFEYFRDQQVNYAVIEVGLGGRLDSTNIITPILSI 162
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAM-DVLIQYADSLKCP 1010
IT + LDHT LG+T ++IAA KAGI+K+G A + +++ DV A+ + P
Sbjct: 163 -ITNISLDHTQFLGDTEEKIAAEKAGIIKKGVPALLGEAEKQSVYDVFKNKAEEVGAP 219
>UniRef50_A6TN35 Cluster: FolC bifunctional protein; n=2;
Clostridiaceae|Rep: FolC bifunctional protein -
Alkaliphilus metalliredigens QYMF
Length = 439
Score = 137 bits (331), Expect = 6e-31
Identities = 64/171 (37%), Positives = 105/171 (61%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
++ V+HVAGT GKGS +++ S+L+ G+R G Y+SP+L ER+R++G I + A+
Sbjct: 38 KVKVIHVAGTNGKGSIASLIHSVLKTQGYRVGLYTSPYLEEFTERIRISGEDIPRERLAQ 97
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
+V ++E+ K + P F +T +A+ + +E+VD ++EVG+GG +D TN++
Sbjct: 98 VTEEVKMKIEEMVKSGQNHPTEFEVVTAIAFLYYAQEEVDFVVLEVGLGGRLDATNVINT 157
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
+ IT +G DHT+ LGNT++EIA K G++K Q EA+ VL
Sbjct: 158 PLLSIITPIGYDHTAYLGNTLKEIAFEKGGVIKEDGLTLVAPQEEEALQVL 208
>UniRef50_Q11UV3 Cluster: Tetrahydrofolylpolyglutamate synthase; n=1;
Cytophaga hutchinsonii ATCC 33406|Rep:
Tetrahydrofolylpolyglutamate synthase - Cytophaga
hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Length = 429
Score = 136 bits (330), Expect = 8e-31
Identities = 71/178 (39%), Positives = 109/178 (61%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+HVAGT GKGS+S++ ++L+ G+ G Y+SPH+ ER+R+NG I +D+ + +
Sbjct: 49 IHVAGTNGKGSSSSILAAVLQSAGYTVGLYTSPHIHDFTERIRINGVPIPKDIVVDFVQN 108
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
+T F+ P +F T++A+ F K++VD+AI+E G+GG +D TNI++ V
Sbjct: 109 ------NTAVFDRFKPSFFEITTILAFVWFAKQQVDIAIIETGMGGRLDATNIVQP-EVS 161
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
IT + LDHT LGNTIQ IA+ KAGI+K G + E + V + A++L PL
Sbjct: 162 LITNVSLDHTQFLGNTIQAIASEKAGIIKAGIPVVISELQQELISVYEEQANALNSPL 219
>UniRef50_Q03Z01 Cluster: Folylpolyglutamate synthase; n=1;
Leuconostoc mesenteroides subsp. mesenteroides ATCC
8293|Rep: Folylpolyglutamate synthase - Leuconostoc
mesenteroides subsp. mesenteroides (strain ATCC 8293
/NCDO 523)
Length = 393
Score = 136 bits (330), Expect = 8e-31
Identities = 80/214 (37%), Positives = 118/214 (55%), Gaps = 1/214 (0%)
Frame = +3
Query: 342 LQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSA 521
+++ + I I + GQK +L M L+ G + L +HV GT GKGS S
Sbjct: 1 MKTVEDAISYIHNRPKGGQK-ESLYRMTTLLAALGNPQNDLPY--AIHVTGTNGKGSVST 57
Query: 522 MCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQ-KFEG 698
M +ILR G+ TG + SP + RER+++N +IS+D + V Q L + +
Sbjct: 58 MASNILRVAGYDTGLFVSPFITNFRERIQINNEMISKDDLLHATNKVAQVLVNVDAELYP 117
Query: 699 DMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSIL 878
D+P F LT + + F +K+D ++EVGIGGL+D TN++ V IT++GLDH +L
Sbjct: 118 DIPVEFEVLTAIMFTYFSSKKLDALVIEVGIGGLLDSTNVMPNTKVAVITSVGLDHQKML 177
Query: 879 GNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
GNTI EIA+ KAGI+ T P+EA V+
Sbjct: 178 GNTITEIASQKAGIIHDDVAVVTGDLPDEARLVI 211
>UniRef50_Q18QE7 Cluster: FolC bifunctional protein; n=5;
Clostridia|Rep: FolC bifunctional protein -
Desulfitobacterium hafniense (strain DCB-2)
Length = 454
Score = 136 bits (329), Expect = 1e-30
Identities = 75/201 (37%), Positives = 111/201 (55%)
Frame = +3
Query: 420 MENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRE 599
+E L R G + + L VVH+ GT GKGST+ M IL G+R G ++SPHL RE
Sbjct: 45 IEELLKRMG---NPEERLRVVHIGGTNGKGSTTMMTAEILEDAGYRVGVFTSPHLHDYRE 101
Query: 600 RVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIV 779
R+ +NG +I + + + LE+ + + P F T MA F +KVD+ ++
Sbjct: 102 RITINGEMIPKGEVTRLIQILRPHLEELVQKGVEHPTEFEVNTAMALMYFADQKVDLVLL 161
Query: 780 EVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQP 959
EVG+GG +D TN+++ + V IT +G+DH LG T +EIA KAGI+K G T
Sbjct: 162 EVGLGGAIDSTNVVKPLISV-ITNVGMDHMDYLGETYEEIAGVKAGIIKAGAITVTAADR 220
Query: 960 NEAMDVLIQYADSLKCPLTXV 1022
E ++V+ + A + PL V
Sbjct: 221 PEVLNVIRKKAQEMNSPLWVV 241
>UniRef50_Q04E69 Cluster: Folylpolyglutamate synthase; n=2; Oenococcus
oeni|Rep: Folylpolyglutamate synthase - Oenococcus oeni
(strain BAA-331 / PSU-1)
Length = 404
Score = 136 bits (329), Expect = 1e-30
Identities = 82/226 (36%), Positives = 123/226 (54%), Gaps = 3/226 (1%)
Frame = +3
Query: 342 LQSNKSTIEQIRKDIRTGQKCTN--LEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGST 515
+++ +E I + G++ + E + N L + G KL +++HV GT GKGS
Sbjct: 2 IENENEAVEWIHSLTKAGKRAKHDTQERLLNLLEKIGHPEKKLP--AIIHVTGTNGKGSV 59
Query: 516 SAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFE 695
S ++IL G+RTG + SP ++ ER+ ++G+ IS+D KY V + D +FE
Sbjct: 60 SRFSQAILTASGYRTGLFVSPFIIKFNERIEIDGKYISDDDLLKYTRIVFENYTDQTEFE 119
Query: 696 GDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSI 875
+T +A F + +D +VEVGIGGL D TN+L V IT++GLDH I
Sbjct: 120 --------VITAIAILYFSESHLDALVVEVGIGGLWDSTNVL-DATVAVITSVGLDHMDI 170
Query: 876 LGNTIQEIAASKAGIMKRGCEAYTVQQ-PNEAMDVLIQYADSLKCP 1010
LG+T+ +IA K GI+K +A + PNEA DV+ A LK P
Sbjct: 171 LGDTLAKIAFQKVGIVKPSTKALVYGRIPNEAKDVIEARAKELKIP 216
>UniRef50_A5KJF0 Cluster: Putative uncharacterized protein; n=2;
Clostridiales|Rep: Putative uncharacterized protein -
Ruminococcus torques ATCC 27756
Length = 445
Score = 136 bits (329), Expect = 1e-30
Identities = 64/183 (34%), Positives = 105/183 (57%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
D+L +H+AGT GKGS A +IL G+R G Y SP +V+ RER++++G +IS+ FA
Sbjct: 47 DDLRFIHIAGTNGKGSVLAYTSTILSEAGYRIGRYVSPTVVSYRERIQVDGEMISKHAFA 106
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
+ V + ++ +P F T +A+ + + K D ++E G+GG+ D TN+++
Sbjct: 107 EETEKVQDAIVRLKEAGKQLPTVFEAETAIAFLYYKRMKCDFVVLESGLGGMEDATNVVK 166
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLK 1004
+ + +DH ++GNT+ EIA +KAGI+K GC + Q E ++L Q A
Sbjct: 167 NTVCAVFSPISMDHIGVIGNTLSEIAENKAGIIKPGCIVVSAPQKQEVREILEQKARQFG 226
Query: 1005 CPL 1013
CP+
Sbjct: 227 CPI 229
>UniRef50_A5D456 Cluster: Folylpolyglutamate synthase; n=1;
Pelotomaculum thermopropionicum SI|Rep:
Folylpolyglutamate synthase - Pelotomaculum
thermopropionicum SI
Length = 430
Score = 136 bits (329), Expect = 1e-30
Identities = 74/185 (40%), Positives = 107/185 (57%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
+L +H+ GT GKGST+ M IL+ G+RTG ++SPHL + ER R++G IS + A+
Sbjct: 41 DLKAIHIGGTNGKGSTAVMLAGILQKAGYRTGAFTSPHLHSFTERYRIDGACISRERIAE 100
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
++ LE + P F T +A+ F +EKVD ++EVG+GG D TN++R
Sbjct: 101 LTGEMRPHLEAMAADGFERPTGFEAGTALAFLYFSREKVDYLVLEVGLGGRCDATNVVRP 160
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKC 1007
+ V IT + +DH LGN+I+EIA KAGI+KRG T EA++V+
Sbjct: 161 LLSV-ITNVSVDHQEYLGNSIREIAGEKAGIIKRGVPTVTA-AAGEALEVIEDTCRKRNS 218
Query: 1008 PLTXV 1022
PLT V
Sbjct: 219 PLTVV 223
>UniRef50_Q8G4M5 Cluster: Folylpolyglutamate synthase; n=4;
Bifidobacterium|Rep: Folylpolyglutamate synthase -
Bifidobacterium longum
Length = 529
Score = 136 bits (328), Expect = 1e-30
Identities = 76/179 (42%), Positives = 106/179 (59%), Gaps = 6/179 (3%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+H+ GT GKGST+ M E+I R +G RTG Y+SPHL + ER+ ++G+ +S+D F +
Sbjct: 41 VIHITGTNGKGSTARMAEAICRAYGMRTGLYTSPHLEKINERIAIDGQQLSDDDFIDIWD 100
Query: 657 DVHQ--RLEDTQKFEGDMPK--YFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
L D + E PK +F LT MA F VDVAIVEVG+GGL D TN+L
Sbjct: 101 QTKDLVALVDAKMEEQGKPKMSFFEVLTAMAIWKFADTPVDVAIVEVGMGGLWDATNVLN 160
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNE--AMDVLIQYAD 995
+ I + +DH LG+T+++IA KAGI+K C A QP+E M +L + A+
Sbjct: 161 ADAAI-IGPVDMDHMQWLGDTVEQIATEKAGIIKPNCTAIIGPQPHEEAVMPILTEAAE 218
>UniRef50_A3ZWP1 Cluster: Folyl-polyglutamate synthetase; n=1;
Blastopirellula marina DSM 3645|Rep: Folyl-polyglutamate
synthetase - Blastopirellula marina DSM 3645
Length = 470
Score = 135 bits (327), Expect = 2e-30
Identities = 69/156 (44%), Positives = 99/156 (63%), Gaps = 1/156 (0%)
Frame = +3
Query: 462 LDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMF 641
+D+L +VH+AGTKGKGST+ +IL G++ G +SSPHL + ER +N S D
Sbjct: 64 VDQLKIVHIAGTKGKGSTATTLSAILEADGYQVGLFSSPHLERLEERFAINRIACSADEV 123
Query: 642 AKYFHDVHQ-RLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNI 818
+ HD+ L+ + +GD P YF T MA F+++ VD AI+EVG+GG +D TNI
Sbjct: 124 TQLIHDIAPVVLQIDAERDGDGPTYFEITTAMALMHFVRKGVDAAILEVGLGGRLDSTNI 183
Query: 819 LRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
R + V IT + DH ++LG+T+ EIAA KAG++K
Sbjct: 184 CRPLVSV-ITTISRDHMALLGDTLAEIAAEKAGVIK 218
>UniRef50_Q8W041 Cluster: Dihydrofolate synthetase; n=5; core
eudicotyledons|Rep: Dihydrofolate synthetase -
Arabidopsis thaliana (Mouse-ear cress)
Length = 530
Score = 135 bits (327), Expect = 2e-30
Identities = 65/154 (42%), Positives = 98/154 (63%), Gaps = 2/154 (1%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
VVHVAGTKGKGSTSA +ILR G+ G YSSPH+++++ER+ NG +S F+
Sbjct: 96 VVHVAGTKGKGSTSAFLSNILRAGGYSVGCYSSPHILSIKERISCNGEPVSASTLNDLFY 155
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V LE + + E +F LT +A+++F KE VD+A++E G+GG D TN++ +
Sbjct: 156 SVKPILEQSIQEENGSLSHFEILTGIAFSLFEKENVDIAVIEAGLGGARDATNVIESSNL 215
Query: 837 VG--ITALGLDHTSILGNTIQEIAASKAGIMKRG 932
IT +G +H + LG +++ IA +K+GI+K G
Sbjct: 216 AASVITTIGEEHMAALGGSLESIAEAKSGIIKHG 249
>UniRef50_Q7NLP7 Cluster: Folylpolyglutamate synthase; n=1;
Gloeobacter violaceus|Rep: Folylpolyglutamate synthase -
Gloeobacter violaceus
Length = 413
Score = 134 bits (324), Expect = 4e-30
Identities = 79/199 (39%), Positives = 108/199 (54%), Gaps = 4/199 (2%)
Frame = +3
Query: 432 LSRTGVTMSKLDELSV----VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRE 599
L R + +L E V VHVAGT GKGS A IL+ G+RTG Y+SPHL+ E
Sbjct: 19 LERIQALLKRLGEPQVAFQAVHVAGTNGKGSVCAYLSHILQTAGYRTGRYTSPHLLDWNE 78
Query: 600 RVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIV 779
R+ ++G IS+ V E K G+ P F +T A+ F + V+VA+V
Sbjct: 79 RIWIDGAFISDGALQACLAKVKASAEHLPKSLGE-PTQFEIVTAAAFLHFAQSAVEVAVV 137
Query: 780 EVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQP 959
EVG+GG +D TN+ + P IT +GLDH LG+T+ IAA KAGI++ GC
Sbjct: 138 EVGLGGRLDATNVFEQPPASVITGIGLDHCDQLGSTLAAIAAEKAGILRSGCPLVCAPLA 197
Query: 960 NEAMDVLIQYADSLKCPLT 1016
EAM V+ + A +L +T
Sbjct: 198 PEAMQVVTEKALALGVVIT 216
>UniRef50_A3HTE9 Cluster: Folylpolyglutamate synthase; n=3;
Bacteria|Rep: Folylpolyglutamate synthase - Algoriphagus
sp. PR1
Length = 428
Score = 134 bits (324), Expect = 4e-30
Identities = 78/202 (38%), Positives = 114/202 (56%), Gaps = 2/202 (0%)
Frame = +3
Query: 414 EDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAV 593
+D+ N L+ + + +HVAGT GKGSTS +IL+ G++TG Y+SPHL +
Sbjct: 27 KDLSNTLALCDHLRNPEKKFKSIHVAGTNGKGSTSHSLAAILQKAGYKTGLYTSPHLKSF 86
Query: 594 RERVRLNGRVISEDMFAKYFHDVHQRLEDTQKF-EGDMPKYFAFLTVMAYNIFLKEKVDV 770
ER++++G I ED +V Q +++ + F E P +F MA+ F KE VDV
Sbjct: 87 TERIKIDGIEIPED-------EVVQFVKENKTFIENLKPSFFEMTVAMAFWHFAKESVDV 139
Query: 771 AIVEVGIGGLVDYTNILRKVPVVG-ITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYT 947
A++EVG+GG D TN++ +P + IT +G DH LGNT+ EIA KAGI+K+
Sbjct: 140 AVIEVGMGGKFDSTNVI--LPEISVITNIGFDHVQFLGNTLPEIAGEKAGIIKQRIPVVI 197
Query: 948 VQQPNEAMDVLIQYADSLKCPL 1013
Q E V IQ A S+ +
Sbjct: 198 SQTQVETKPVFIQKAQSVSASI 219
>UniRef50_Q1EVW0 Cluster: Folylpolyglutamate synthetase; n=1;
Clostridium oremlandii OhILAs|Rep: Folylpolyglutamate
synthetase - Clostridium oremlandii OhILAs
Length = 439
Score = 134 bits (323), Expect = 6e-30
Identities = 69/192 (35%), Positives = 112/192 (58%)
Frame = +3
Query: 417 DMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVR 596
D+E+ + + ++L +H+AGT GKGSTS+ S+L+ G++ G ++SPHL
Sbjct: 21 DLEHMKILLQILGNPQNQLKFIHIAGTNGKGSTSSFIHSMLKAEGYQVGLFTSPHLHCYT 80
Query: 597 ERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAI 776
+R+R+NG IS++ FA+Y V + + + + P F +T++A F KE VD +
Sbjct: 81 DRIRINGVNISKEDFARYTSMVEETIAPFYEQGFNHPALFDIVTLVAMMYFAKENVDYVV 140
Query: 777 VEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQ 956
+EVG+GGL D TNI+ + IT +G+DH ILG +++IA KAGI+K + Q
Sbjct: 141 LEVGLGGLNDATNIISQSLASVITPIGIDHVDILGTDLKQIAYHKAGIIKSQGRVISTWQ 200
Query: 957 PNEAMDVLIQYA 992
+VL++ A
Sbjct: 201 DPIVEEVLVETA 212
>UniRef50_A7LS10 Cluster: Putative uncharacterized protein; n=1;
Bacteroides ovatus ATCC 8483|Rep: Putative
uncharacterized protein - Bacteroides ovatus ATCC 8483
Length = 496
Score = 134 bits (323), Expect = 6e-30
Identities = 68/155 (43%), Positives = 98/155 (63%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
+ +H+AGT GKGS S ++L+ G+R G ++SPHL+ RER+R+NG +I E+ +
Sbjct: 45 QFKTIHIAGTNGKGSCSHTIAAVLQCAGYRVGLFTSPHLIDFRERIRINGEMIPEE-YVV 103
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
F + H+ FE P +F T MA+ F +KVDVA++EVG+GG +D TNI+
Sbjct: 104 NFVEEHRSF-----FEPLHPSFFELTTAMAFRYFADQKVDVAVIEVGMGGRLDCTNIIHP 158
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
V IT +GLDHT LG+T+ +IA KAGI+K G
Sbjct: 159 DLCV-ITNIGLDHTQYLGDTLTKIAKEKAGIIKEG 192
>UniRef50_Q1IVH6 Cluster: FolC bifunctional protein; n=1;
Acidobacteria bacterium Ellin345|Rep: FolC bifunctional
protein - Acidobacteria bacterium (strain Ellin345)
Length = 447
Score = 132 bits (320), Expect = 1e-29
Identities = 73/171 (42%), Positives = 105/171 (61%), Gaps = 4/171 (2%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMF-AKYFH 656
V +AGT GKGST+A SIL G++TG Y+SPHLV + ER R+NG +++ F A Y H
Sbjct: 47 VLIAGTNGKGSTAATLSSILLAAGYKTGLYTSPHLVKINERFRINGSQVNDAEFTAAYEH 106
Query: 657 --DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKV 830
+ L +T+ P +F LT MA+ +F + + +A++EVG+GG +D TN++
Sbjct: 107 VETLASALVETKALPWH-PSFFEMLTAMAFELFARAGIQIAVLEVGMGGRLDATNVVE-- 163
Query: 831 PVVGITA-LGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
P++ + A + LDH LGNTI EIAA KAGI+K T+ Q A DV+
Sbjct: 164 PLISVIADISLDHQKFLGNTIAEIAAEKAGIIKPNGTVVTLPQHPAANDVI 214
>UniRef50_A4M5Q3 Cluster: FolC bifunctional protein; n=1; Petrotoga
mobilis SJ95|Rep: FolC bifunctional protein - Petrotoga
mobilis SJ95
Length = 438
Score = 132 bits (319), Expect = 2e-29
Identities = 68/174 (39%), Positives = 103/174 (59%), Gaps = 1/174 (0%)
Frame = +3
Query: 411 LEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVA 590
LE ++ R G S + +H+ GT GKGS + ILR +G + G Y SPHLV+
Sbjct: 24 LERIDELSKRIG---SPQNTFKSIHITGTNGKGSVTTAISRILRFNGMKVGTYISPHLVS 80
Query: 591 VRERVRLNGRVISEDMFAKYFHDVHQRLEDTQ-KFEGDMPKYFAFLTVMAYNIFLKEKVD 767
+ ER+++NG ISE F + ++++ + ++ K E P +F T MA+ F K+KVD
Sbjct: 81 ITERIKVNGENISEKEFVEIYNEIEEEIKTMDLKGEEYAPSFFEITTAMAFKYFEKQKVD 140
Query: 768 VAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKR 929
V + EVG+GG +D TNI+ V IT++ DH LG+T++ IA KAGI+K+
Sbjct: 141 VGVFEVGLGGRLDATNIINS-DVSVITSISKDHIKTLGDTLEAIAYEKAGIIKK 193
>UniRef50_A5ZI35 Cluster: Putative uncharacterized protein; n=1;
Bacteroides caccae ATCC 43185|Rep: Putative
uncharacterized protein - Bacteroides caccae ATCC 43185
Length = 493
Score = 132 bits (318), Expect = 2e-29
Identities = 66/155 (42%), Positives = 96/155 (61%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
+ +H+AGT GKGS S ++L+ G+R G ++SPHLV RER+R+NG +I E+
Sbjct: 45 QFKTIHIAGTNGKGSCSHTIAAVLQSAGYRVGLFTSPHLVDFRERIRINGEMIPEEYVVN 104
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
+ D H+ FE P +F T MA+ F +KVDVA++EVG+GG +D TNI++
Sbjct: 105 FVAD-HRSF-----FEPLHPSFFELTTAMAFRYFADQKVDVAVIEVGMGGRLDCTNIIQP 158
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
+ IT +G DH LG+T+ +IA KAGI+K G
Sbjct: 159 DLCI-ITNIGFDHMQYLGDTLPKIAKEKAGIIKEG 192
>UniRef50_A5KLT5 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus torques ATCC 27756|Rep: Putative
uncharacterized protein - Ruminococcus torques ATCC
27756
Length = 396
Score = 132 bits (318), Expect = 2e-29
Identities = 63/170 (37%), Positives = 102/170 (60%)
Frame = +3
Query: 471 LSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKY 650
+ ++HVAGT GKGS A + +LR RTG ++SPHLV + ER+ ++G++IS++ F +
Sbjct: 1 MRIIHVAGTNGKGSVCAYLDGMLRSEQKRTGLFTSPHLVKINERIVIDGQMISDERFLEV 60
Query: 651 FHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKV 830
F + Q ++ ++ P +F FL MA F + V+ A++E G+GG +D TN +
Sbjct: 61 FEETMQAVDKMKEAGLSHPTFFEFLFGMAVLAFAESGVEYAVLETGLGGRLDATNAVESP 120
Query: 831 PVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
IT++G DH LG+T+++IA+ KAGI+K Y Q E+ V+
Sbjct: 121 AASVITSIGFDHEQYLGDTLEKIASEKAGIIKPHVPVYYAQTTGESDSVI 170
>UniRef50_Q82ZW9 Cluster: FolC family protein; n=7; Firmicutes|Rep:
FolC family protein - Enterococcus faecalis
(Streptococcus faecalis)
Length = 440
Score = 131 bits (316), Expect = 4e-29
Identities = 72/201 (35%), Positives = 115/201 (57%), Gaps = 7/201 (3%)
Frame = +3
Query: 432 LSRTGVTMSKLD----ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRE 599
L R + K+D ++ +H+AGT GKGST +L G + G ++SP++ + E
Sbjct: 24 LDRINALLEKIDHPENKVPTIHIAGTNGKGSTVTYLRCLLEEMGLKVGTFTSPYIESFNE 83
Query: 600 RVRLNGRVISEDMFAKY---FHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDV 770
R+ +NG+ IS++ Y + + + L+ + G F LT MA + F+ E+VD+
Sbjct: 84 RIAINGQPISDEQLITYVEKYQPIIKELDQITEVAGITE--FETLTGMALDYFVNEQVDI 141
Query: 771 AIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTV 950
A+VEVG+GGL+D TN+++ + + GIT +G DHT ILG TI EIA KAGI+K T
Sbjct: 142 AVVEVGLGGLLDSTNVVKPL-LTGITTIGKDHTEILGETIAEIAYQKAGIIKEKVPVVTG 200
Query: 951 QQPNEAMDVLIQYADSLKCPL 1013
+A+ V+ + A + P+
Sbjct: 201 NICADALAVIEKVAQEKQSPI 221
>UniRef50_Q7UQM1 Cluster: Folylpolyglutamate synthase/dihydrofolate
synthase; n=1; Pirellula sp.|Rep: Folylpolyglutamate
synthase/dihydrofolate synthase - Rhodopirellula baltica
Length = 543
Score = 130 bits (314), Expect = 7e-29
Identities = 67/189 (35%), Positives = 103/189 (54%)
Frame = +3
Query: 447 VTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVI 626
V SK + +VH+AGTKGKGS + M ++L G+R G Y+SPHLV + ER R++G +
Sbjct: 112 VQPSKSTGVQIVHLAGTKGKGSAATMVAALLHSAGYRVGLYTSPHLVNLEERFRVDGEIA 171
Query: 627 SEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVD 806
+ + + +E P +F T MA F + + D+ ++E G+GG +D
Sbjct: 172 TPEEMIGLIDSMRPIVEAMTAAPIGGPSFFELTTAMAIEHFHRRQCDIWVLETGLGGRLD 231
Query: 807 YTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQ 986
TN+ + IT++GLDH +LG+T + IAA KAGI KR A DV+++
Sbjct: 232 STNVFQS-HATAITSIGLDHQHVLGDTAELIAAEKAGIFKRDTPAINGVPAGPVRDVIVR 290
Query: 987 YADSLKCPL 1013
A+ + PL
Sbjct: 291 IANQIGAPL 299
>UniRef50_Q2RZW2 Cluster: Dihydrofolate synthetase; n=1; Salinibacter
ruber DSM 13855|Rep: Dihydrofolate synthetase -
Salinibacter ruber (strain DSM 13855)
Length = 435
Score = 130 bits (314), Expect = 7e-29
Identities = 70/183 (38%), Positives = 103/183 (56%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
+ L VHVAGT GKGST+AM +I G RTG ++SPHL V +R+R++G D A
Sbjct: 41 EALRAVHVAGTNGKGSTAAMTAAIATAAGLRTGLHTSPHLTHVAQRMRVDGTPAPTDWLA 100
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
+ED + P +F + + F ++ VD+A++EVG+GG +D TN+L
Sbjct: 101 DTLGQHRSLVEDVR------PSFFELAVALTFRYFAEQNVDLAVIEVGLGGRLDSTNVLA 154
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLK 1004
V +T +GLDHT +LG+T+ IA KAGI+K A + P+EA + + A +
Sbjct: 155 PALSV-LTHVGLDHTDMLGDTLDAIAREKAGIIKPETPALSAVTPDEAQAAIAEVAATQD 213
Query: 1005 CPL 1013
PL
Sbjct: 214 APL 216
>UniRef50_Q7SFD9 Cluster: Putative uncharacterized protein
NCU00893.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU00893.1 - Neurospora crassa
Length = 513
Score = 130 bits (313), Expect = 9e-29
Identities = 93/261 (35%), Positives = 141/261 (54%), Gaps = 49/261 (18%)
Frame = +3
Query: 312 YEXAVRKLNRLQSNKSTIEQIRKDIRTG---------QKCTN---LEDMENYLSRTGVTM 455
Y+ A+ +L +LQSN++ + D +K N + +M ++L+R G T
Sbjct: 8 YDDALSRLAQLQSNRTIVNLFGSDDSNNDSQSKKPAAKKDLNSLAIPEMLSWLARAGYTP 67
Query: 456 SKLDE--LSVVHVAGTKGKGSTSAMCESILRHH----GFR----------------TGFY 569
S L L VHVAGTKGKGS SA+ SI+ + F G Y
Sbjct: 68 SSLAATGLKCVHVAGTKGKGSVSALVSSIISQYPPPPSFHDDGGGGGAHIIQKPVVVGTY 127
Query: 570 SSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLE-------DTQKFE------GDMPK 710
+SPH+++VRER++L+ +S + FA YF +V RL D + E G P
Sbjct: 128 TSPHVLSVRERIQLDNVPVSREKFALYFFEVWDRLSAAARAARDPVQSEAEYDGPGTKPF 187
Query: 711 YFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVG--ITALGLDHTSILGN 884
YF FLT++A++IF++E V A++E GIGG D TN L V +T LG+DH ++LGN
Sbjct: 188 YFRFLTILAFHIFVREGVKQAVIECGIGGEYDSTNFLSPQCVTASVVTQLGIDHVAMLGN 247
Query: 885 TIQEIAASKAGIMKRGCEAYT 947
T+++IA +K+GI ++G + +T
Sbjct: 248 TLEKIAWNKSGIFRKGVKGFT 268
>UniRef50_A7D4G5 Cluster: Dihydropteroate synthase; n=1; Halorubrum
lacusprofundi ATCC 49239|Rep: Dihydropteroate synthase -
Halorubrum lacusprofundi ATCC 49239
Length = 878
Score = 130 bits (313), Expect = 9e-29
Identities = 72/186 (38%), Positives = 112/186 (60%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
+++S V VAG+ GKGST+ M ESILR G G Y+SPHL A+ +RVR++G ++E A
Sbjct: 37 EDVSFVQVAGSNGKGSTARMTESILREAGLSVGLYTSPHLSALADRVRVDGLAMTEAAIA 96
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
+ +V L + + G+ +F +T MA + F + +VDVA++EVG+GG D T+ +
Sbjct: 97 DFVEEVKPWLVE-RAANGEPLTFFEVVTAMAIHDFARREVDVAVLEVGLGGEYDATSAVD 155
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLK 1004
V +T + L+HT++LG+TI EIA +KA I G T + EA+ V+ + A+
Sbjct: 156 PV-ATAVTNVSLEHTAVLGDTIAEIARTKARIADAGVPLVTACE-GEALSVVREVANDAG 213
Query: 1005 CPLTXV 1022
P+ V
Sbjct: 214 APIATV 219
>UniRef50_Q1FIY8 Cluster: FolC bifunctional protein; n=1;
Clostridium phytofermentans ISDg|Rep: FolC bifunctional
protein - Clostridium phytofermentans ISDg
Length = 424
Score = 129 bits (311), Expect = 2e-28
Identities = 68/173 (39%), Positives = 102/173 (58%), Gaps = 2/173 (1%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
+L +HVAGT GKGST M SILR G + G ++SP L E++++NG VIS + FAK
Sbjct: 38 KLKFIHVAGTNGKGSTCKMLSSILRCAGLKVGLFTSPFLETENEQIQINGEVISNEDFAK 97
Query: 648 YFHDVHQRLED--TQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNIL 821
V ++++D T ++P F T MA+ F K D+ ++EVG+GG +D TN++
Sbjct: 98 ----VCKKVKDFTTYLMLDEIPTEFELTTAMAFQYFYDTKCDLVVLEVGLGGELDATNVI 153
Query: 822 RKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
V +T +G+DH LG T++EIA KAGI+K + +Q E +V+
Sbjct: 154 ETPLVSVLTNIGIDHVDYLGTTLKEIACKKAGIIKENGIVVSYEQEKEVEEVI 206
>UniRef50_A6WDS1 Cluster: FolC bifunctional protein precursor; n=1;
Kineococcus radiotolerans SRS30216|Rep: FolC
bifunctional protein precursor - Kineococcus
radiotolerans SRS30216
Length = 526
Score = 128 bits (310), Expect = 2e-28
Identities = 70/172 (40%), Positives = 104/172 (60%), Gaps = 4/172 (2%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
VVH+AGT GK ST+ M E ++R H RTG ++SPHLV + ER+ ++G I+ F + +
Sbjct: 117 VVHLAGTNGKTSTARMVERLVREHDLRTGRFTSPHLVDITERIAVDGDPITHAAFVRAWD 176
Query: 657 DVHQ--RLEDTQKFEGDMPK--YFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
DV + D + E P+ +F LT+MA+ F VDVA++E G+GG D TN+++
Sbjct: 177 DVEPVVSIVDARAAERGEPRLSFFEVLTLMAFAAFADAPVDVAVIETGLGGTWDTTNVVQ 236
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
V +T + +DH + LG+T++EIA KAGI+K G +Q EA VL
Sbjct: 237 P-DVAVVTPVSMDHEAWLGSTLEEIAGQKAGIIKHGSIVVIGKQEEEAGAVL 287
>UniRef50_Q2RNS0 Cluster: Folylpolyglutamate synthetase; n=4;
Rhodospirillaceae|Rep: Folylpolyglutamate synthetase -
Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)
Length = 435
Score = 128 bits (309), Expect = 3e-28
Identities = 68/179 (37%), Positives = 97/179 (54%), Gaps = 1/179 (0%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+HVAGT GKGS A C ++L G+R Y+SPHLV ER+RL G +I+++ +
Sbjct: 43 VIHVAGTNGKGSVVATCRALLEAAGYRVHVYTSPHLVRFGERIRLAGTLIADEALRRL-- 100
Query: 657 DVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
LE+ + P +F T A+ F + DV ++EVG+GG +D TN++
Sbjct: 101 -----LEEVESANAKAPITFFEVTTAAAFLAFSRSPADVTLLEVGLGGRLDATNVIADPA 155
Query: 834 VVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCP 1010
V +T + LDH LG+T+ IA KAGI+K G A QP EA L A ++ P
Sbjct: 156 VCAVTPIDLDHQQYLGSTLTAIAGEKAGILKAGAPAVIAPQPPEAAQTLAARATAVGAP 214
>UniRef50_Q04MP6 Cluster: Folylpolyglutamate synthase; n=14;
Streptococcus|Rep: Folylpolyglutamate synthase -
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC
7466)
Length = 418
Score = 128 bits (309), Expect = 3e-28
Identities = 67/175 (38%), Positives = 107/175 (61%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
++HV GT GKGST A + HG + ++SPH+V++ +R+ +NG+ I++ F +
Sbjct: 41 IIHVTGTNGKGSTIAFMRELFMGHGKKVATFTSPHIVSINDRICINGQPIADADFIRLAD 100
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V + +E T D +F LT++A+ F ++VD+ ++EVGIGGL+D TN++
Sbjct: 101 QV-KEMEKTLLQTPDQLSFFELLTLVAFLYFRGQEVDLVLLEVGIGGLLDTTNVVTGELA 159
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSL 1001
V IT++GLDH LG++++ IA KAGI K G +A + P EA V + A+SL
Sbjct: 160 V-ITSIGLDHQETLGDSLEAIAEQKAGIFKAGKKAVIAKLPPEARLVCQKKAESL 213
>UniRef50_Q5CBK3 Cluster: Folylpolyglutamate synthase/dihydrofolate
synthase; n=7; Thermotoga|Rep: Folylpolyglutamate
synthase/dihydrofolate synthase - Thermotoga petrophila
Length = 437
Score = 128 bits (308), Expect = 4e-28
Identities = 72/188 (38%), Positives = 105/188 (55%), Gaps = 5/188 (2%)
Frame = +3
Query: 432 LSRTGVTMSKLD----ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRE 599
L R + +SKL + +HV GT GKGS + M IL G+R G Y SPHL RE
Sbjct: 30 LERISMLLSKLGNPHLKYKSIHVGGTNGKGSVTNMISHILISQGYRVGSYYSPHLSTFRE 89
Query: 600 RVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIV 779
R+RLN ISE+ K + + L + K E P +F +T MA+ F ++ VD+A++
Sbjct: 90 RIRLNEEYISEEDVVKIYEKMEPILNELDKEEIFSPSFFEVVTAMAFLYFAEKNVDIAVL 149
Query: 780 EVGIGGLVDYTNILRKVPVVG-ITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQ 956
EVG+GG +D TN++ P+ I + DH LG TI++IA K+GI+K T ++
Sbjct: 150 EVGLGGRLDATNVV--FPLCSTIVTVDRDHEKTLGYTIEQIAWEKSGIIKERVPLVTGER 207
Query: 957 PNEAMDVL 980
EA+ V+
Sbjct: 208 KREALKVM 215
>UniRef50_A6DMK1 Cluster: Folylpolyglutamate synthase; n=1;
Lentisphaera araneosa HTCC2155|Rep: Folylpolyglutamate
synthase - Lentisphaera araneosa HTCC2155
Length = 423
Score = 128 bits (308), Expect = 4e-28
Identities = 69/169 (40%), Positives = 97/169 (57%)
Frame = +3
Query: 420 MENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRE 599
+EN + + L VHVAGT GKGST AM + ++ G +TGFYSSP LV E
Sbjct: 26 LENMIQLNQLLGDPASSLKFVHVAGTNGKGSTCAMIATACKYAGLKTGFYSSPFLVNFLE 85
Query: 600 RVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIV 779
R R+NG I+E ++ + ++ + G P YF LT A IF +EK +V I
Sbjct: 86 RWRINGSPINESIYLDAMQKIIAIEDELVERTGVKPTYFEVLTAAALLIFKEEKCEVVIW 145
Query: 780 EVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
E G+GG +D TNI + + IT + +DH S LG+T++E+A KAGI+K
Sbjct: 146 ETGMGGRLDATNIANPLLTI-ITNIAMDHGSYLGDTLEEVAKEKAGIIK 193
>UniRef50_A1HP48 Cluster: FolC bifunctional protein; n=1;
Thermosinus carboxydivorans Nor1|Rep: FolC bifunctional
protein - Thermosinus carboxydivorans Nor1
Length = 429
Score = 128 bits (308), Expect = 4e-28
Identities = 73/172 (42%), Positives = 104/172 (60%), Gaps = 1/172 (0%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
VHV GT GKGST+AM +IL+ G +TG Y+SPHLV ER+ ++GR + FA D
Sbjct: 42 VHVTGTNGKGSTTAMLAAILQASGIKTGMYTSPHLVDYTERMVVDGRPAAPAAFAAAI-D 100
Query: 660 VHQRLEDTQKFEG-DMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
+R + EG + P F LT A++ F + KV+ A++EVG+GGL+D TN++
Sbjct: 101 YTRRFIEQMTAEGWEHPTEFEVLTAAAFHYFAEAKVEYAVIEVGLGGLLDSTNVISPEAA 160
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYA 992
V IT + L+HT G T++EIA KAGI+K G T + EA+ V+ + A
Sbjct: 161 V-ITNVALEHTDRCGATVREIARHKAGIIKAGVPVITAAE-GEALAVIREAA 210
>UniRef50_Q05865 Cluster: Folylpolyglutamate synthase; n=4;
Bacillus|Rep: Folylpolyglutamate synthase - Bacillus
subtilis
Length = 430
Score = 128 bits (308), Expect = 4e-28
Identities = 72/198 (36%), Positives = 108/198 (54%), Gaps = 1/198 (0%)
Frame = +3
Query: 420 MENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRE 599
M+ ++R G K+ HVAGT GKGST A S+L+ G+ G ++SP+++ E
Sbjct: 27 MKQLMARLGHPEKKI---RAFHVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNE 83
Query: 600 RVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLK-EKVDVAI 776
R+ +NG IS++ + + + +E + E P F +T A+ F + KVD I
Sbjct: 84 RISVNGIPISDEEWTALVNQMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVI 143
Query: 777 VEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQ 956
E G+GG D TN++ + V IT++G DH +ILGNTI+EIA KAGI+K G T
Sbjct: 144 FETGLGGRFDSTNVVEPLLTV-ITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVT 202
Query: 957 PNEAMDVLIQYADSLKCP 1010
EA+ V+ A+ P
Sbjct: 203 QPEALQVIRHEAERHAAP 220
>UniRef50_A0LIV6 Cluster: FolC bifunctional protein; n=1;
Syntrophobacter fumaroxidans MPOB|Rep: FolC bifunctional
protein - Syntrophobacter fumaroxidans (strain DSM 10017
/ MPOB)
Length = 431
Score = 127 bits (307), Expect = 5e-28
Identities = 73/184 (39%), Positives = 102/184 (55%), Gaps = 1/184 (0%)
Frame = +3
Query: 411 LEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVA 590
L N L R G + L +H+AGT GKGST+AM S+LR HG R G Y+SPHLV
Sbjct: 28 LNSTNNLLMRLG---NPHRSLRCIHIAGTNGKGSTAAMLSSMLRKHGVRVGLYTSPHLVR 84
Query: 591 VRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDV 770
ER R++ R + D F V ++++D + P +F +T MA +F +E V+
Sbjct: 85 FTERFRIDEREVRIDRILAIFEKVRKQIDDREP-----PTFFEVVTAMALLLFAEENVEW 139
Query: 771 AIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYT- 947
A++E G+GG +D TN++ V IT + DH LG+T+ IA KAGI+K T
Sbjct: 140 AVIETGMGGRLDATNVIHP-RVSVITNVTFDHQEYLGSTLSSIAREKAGIIKEEVPVVTG 198
Query: 948 VQQP 959
V QP
Sbjct: 199 VTQP 202
>UniRef50_Q9K8G9 Cluster: Folyl-polyglutamate synthetase; n=1;
Bacillus halodurans|Rep: Folyl-polyglutamate synthetase -
Bacillus halodurans
Length = 430
Score = 127 bits (306), Expect = 6e-28
Identities = 76/225 (33%), Positives = 126/225 (56%), Gaps = 1/225 (0%)
Frame = +3
Query: 342 LQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSA 521
+Q+ + IE I + G K L+ +E L + G EL+VVH+ GT GKGST +
Sbjct: 1 MQNERQAIEWIHSFLPFGIK-PGLQRIEWMLEKLGHPEK---ELNVVHIGGTNGKGSTVS 56
Query: 522 MCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGD 701
+L G+ G ++SP++ RER+ G IS + + ++ +E+ ++ +
Sbjct: 57 FMRCMLTEAGYNVGTFTSPYIEHFRERIAYKGEPISSEELVRSCLNIIDVVEELKRTDLG 116
Query: 702 MPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILG 881
P F +TV+A++ F + D+ ++EVG+GG +D TNI+ + + IT++G DH ++LG
Sbjct: 117 SPTEFEVITVIAFDFFARVNPDIVLLEVGLGGRLDSTNIVTPLLSI-ITSIGHDHMNVLG 175
Query: 882 NTIQEIAASKAGIMKRGCEAYT-VQQPNEAMDVLIQYADSLKCPL 1013
T++ IA KAGI+K A V+QP EA V+ A+ +K PL
Sbjct: 176 GTLESIAYEKAGIIKPDIPAIVHVKQP-EAFRVIQDKANKVKAPL 219
>UniRef50_Q727H3 Cluster: Folylpolyglutamate synthase; n=2;
Desulfovibrio vulgaris subsp. vulgaris|Rep:
Folylpolyglutamate synthase - Desulfovibrio vulgaris
(strain Hildenborough / ATCC 29579 / NCIMB8303)
Length = 498
Score = 127 bits (306), Expect = 6e-28
Identities = 72/173 (41%), Positives = 96/173 (55%)
Frame = +3
Query: 474 SVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYF 653
+V V GT GKGSTS SI + HG RTG Y+SPH + RER+R++GR++ D +
Sbjct: 43 AVAQVVGTNGKGSTSTFLASIAQAHGLRTGLYTSPHFITPRERIRIDGRMLEADQWPL-- 100
Query: 654 HDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
+ R+ D G YF FLTV+ F + VD+A++E G+GG D T L
Sbjct: 101 --LGNRILDA---GGANLTYFEFLTVLGALAFREAGVDMAVIEAGLGGTWDATTAL-AAD 154
Query: 834 VVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYA 992
++ +T +GLDH +LG TI IA KAG M+ G A T Q EA L Q A
Sbjct: 155 ILCVTPIGLDHQHVLGPTITAIATDKAGAMREGHVALTAPQCGEAFSALAQAA 207
>UniRef50_A5VL10 Cluster: FolC bifunctional protein; n=2;
Lactobacillus reuteri|Rep: FolC bifunctional protein -
Lactobacillus reuteri F275
Length = 419
Score = 127 bits (306), Expect = 6e-28
Identities = 80/237 (33%), Positives = 124/237 (52%), Gaps = 3/237 (1%)
Frame = +3
Query: 360 TIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDE-LSVVHVAGTKGKGSTSAMCESI 536
T EQI Q D +L R + D+ ++H+AGT GKGST M E
Sbjct: 3 TYEQINAGFNR-QMLGGQRDRVKFLRRILTRLGNPDQRFKIIHIAGTNGKGSTGTMLEQG 61
Query: 537 LRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYF 716
L++ G+R G++SSP LV RE++++N +IS+ FA + + + L D+ F
Sbjct: 62 LQNAGYRVGYFSSPALVDDREQIKVNDHLISKKDFAMTYQKITEHLP-ADLLPDDIT-IF 119
Query: 717 AFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQE 896
+ T++ F +KVD A++E G+GG D TNI+ + IT + LDHT ILG TI +
Sbjct: 120 EWWTLIMLQYFADQKVDWAVIECGLGGQDDATNIISAPFISVITHIALDHTRILGPTIAK 179
Query: 897 IAASKAGIMKRGCEAYTV--QQPNEAMDVLIQYADSLKCPLTXVPXYXLLLXRKIXK 1061
IA +KAGI+K G + + Q +A+ ++ + A K LT ++ + I K
Sbjct: 180 IAQAKAGIIKTGTKQVFLAPHQEKDALTIIREKAQQQKVGLTQADAQSIVDGKAILK 236
>UniRef50_A5FP87 Cluster: FolC bifunctional protein; n=3;
Dehalococcoides|Rep: FolC bifunctional protein -
Dehalococcoides sp. BAV1
Length = 438
Score = 126 bits (305), Expect = 8e-28
Identities = 62/172 (36%), Positives = 107/172 (62%), Gaps = 2/172 (1%)
Frame = +3
Query: 471 LSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKY 650
+ VH+AGTKGKGST+++ S++ G+RTG Y+SPHL+ RER+ L+G++IS+D +
Sbjct: 36 IPAVHLAGTKGKGSTASLIASVMSVAGYRTGLYTSPHLLDFRERICLDGKMISKDHLVRL 95
Query: 651 FHDVHQRLED--TQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
+ +++ + G + F +T +A+ F +++ ++E G+GG +D TN++
Sbjct: 96 MASIRPLVDEMNAHAYLGKITS-FEVMTALAFEFFHRQQATFQVIETGLGGRLDATNVIT 154
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
V +T + LDHT +LG+++ +IAA KAGI+K+ + Q EAM V+
Sbjct: 155 PNLSV-LTPISLDHTEVLGDSLDKIAAEKAGIIKQSVPVVSAAQRLEAMAVI 205
>UniRef50_Q92BG3 Cluster: FolC protein; n=11; Listeria|Rep: FolC
protein - Listeria innocua
Length = 429
Score = 126 bits (304), Expect = 1e-27
Identities = 65/172 (37%), Positives = 99/172 (57%), Gaps = 1/172 (0%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
VH+AGT GKGST S L G++TG ++SP++ ER+ +NG +S+ M +
Sbjct: 45 VHIAGTNGKGSTLTFIRSSLEEAGYKTGTFTSPYIETFNERISVNGIPVSDQMIVDLANR 104
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLK-EKVDVAIVEVGIGGLVDYTNILRKVPV 836
+ E+ +K P F +T M + F + E +D+ I+EVG+GG +D TN+L +
Sbjct: 105 IKPIAEELEKTVYGPPSEFEIITAMMFLCFAEYESIDIGIIEVGLGGRLDSTNVLTPLIS 164
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYA 992
V IT +G+DH LGN+I++IA KAGI+K G + EA +V+I A
Sbjct: 165 V-ITTIGMDHMEFLGNSIEQIAGEKAGIIKPGIPVISGVIQKEAQEVIINNA 215
>UniRef50_Q8RBN3 Cluster: Folylpolyglutamate synthase; n=5;
Clostridia|Rep: Folylpolyglutamate synthase -
Thermoanaerobacter tengcongensis
Length = 431
Score = 126 bits (304), Expect = 1e-27
Identities = 73/221 (33%), Positives = 115/221 (52%)
Frame = +3
Query: 354 KSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCES 533
+ I+ I + G K LE+++ L G + L ++HVAGT GKGSTS+ S
Sbjct: 7 EEAIQYIHSTYKFGMKL-GLENIKRLLGYMG---NPEKNLKIIHVAGTNGKGSTSSFISS 62
Query: 534 ILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKY 713
IL+ G++ Y+SP+L ER+++NG IS + Y + + + + P
Sbjct: 63 ILKEAGYKVALYTSPYLEEFEERMKINGENISREKLVYYVEYIKPIIARMVQEGYNHPTE 122
Query: 714 FAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQ 893
F +T +A+ F E+VD ++EVG+GG D TN + V IT++ DH LGNT+
Sbjct: 123 FEVITAIAFKYFSDEEVDFVVLEVGLGGRFDATNAISSSLVSVITSIDYDHMDKLGNTLG 182
Query: 894 EIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLT 1016
+IA KAGI+K+ + Q EA+ V+ + + LT
Sbjct: 183 DIAYEKAGIIKKKGVVVSFYQQEEALKVISDACEVREAYLT 223
>UniRef50_Q6AJ73 Cluster: Related to folylpolyglutamate synthase; n=3;
Deltaproteobacteria|Rep: Related to folylpolyglutamate
synthase - Desulfotalea psychrophila
Length = 441
Score = 126 bits (304), Expect = 1e-27
Identities = 68/182 (37%), Positives = 103/182 (56%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
++ VVHVAGT GKGS + S+L G++ G Y+SPHL + RER R+N IS FA
Sbjct: 49 KMKVVHVAGTNGKGSVCSSLVSVLAKGGYQLGLYTSPHLSSPRERFRINDEYISRADFAC 108
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
+ RL G YF F T +A+ F + VD+ ++E G+GG +D TN++R+
Sbjct: 109 LTDRIRTRLA------GRPITYFEFTTALAFLWFYERGVDLVVLETGLGGRLDATNVVRQ 162
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKC 1007
+ IT++ +DH + LG+TI+ +A+ KAGI+K G + + V+ +A K
Sbjct: 163 PLLTIITSISIDHVAYLGDTIEAVASEKAGIIKEGVPVVCGSYDPKVVAVVAGFAREKKA 222
Query: 1008 PL 1013
PL
Sbjct: 223 PL 224
>UniRef50_Q8A839 Cluster: Folylpolyglutamate synthase; n=1;
Bacteroides thetaiotaomicron|Rep: Folylpolyglutamate
synthase - Bacteroides thetaiotaomicron
Length = 491
Score = 126 bits (303), Expect = 1e-27
Identities = 64/153 (41%), Positives = 95/153 (62%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
+ +H+AGT GKGS S ++L+ G++ G ++SPHL+ RER+R+NG +I ED +
Sbjct: 45 QFRTIHIAGTNGKGSCSHTIAAVLQAAGYKVGLFTSPHLIDFRERIRINGEMIPED-YVV 103
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
F + H+ FE P +F T MA+ F ++VDVA++EVG+GG +D TNI+
Sbjct: 104 SFVEEHRSF-----FEPLHPSFFELTTAMAFRYFADQQVDVAVIEVGMGGRLDCTNIITP 158
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
V IT +G DH LG+T+ +IA KAGI+K
Sbjct: 159 DLCV-ITNIGFDHMQYLGHTLTKIAKEKAGIIK 190
>UniRef50_Q73NR8 Cluster: Folylpolyglutamate synthetase, putative;
n=1; Treponema denticola|Rep: Folylpolyglutamate
synthetase, putative - Treponema denticola
Length = 450
Score = 126 bits (303), Expect = 1e-27
Identities = 69/199 (34%), Positives = 113/199 (56%), Gaps = 1/199 (0%)
Frame = +3
Query: 408 NLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLV 587
NL+ M + G + D+ +H+AG+KGKGS S M SIL+ G +TG Y+SPH+
Sbjct: 26 NLKKMRKFADFFG---NPQDDFLSIHIAGSKGKGSVSTMIASILKEAGKKTGLYTSPHVS 82
Query: 588 AVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDM-PKYFAFLTVMAYNIFLKEKV 764
RER+ G ++ ++ + + + K E ++ P +F +TV A+ +F +K
Sbjct: 83 DFRERMTQAGSFFDDEAYSASYKKIVEGFGAILKKEPEIDPGWFEIVTVTAFLLFSMQKT 142
Query: 765 DVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAY 944
D A++E G+GG +D TNIL+ V +T + L+HT LG+T+++IA KAGI+K +
Sbjct: 143 DWAVIETGMGGRLDMTNILKPRACV-LTPIELEHTQYLGDTLEKIAFEKAGIIKENTPVF 201
Query: 945 TVQQPNEAMDVLIQYADSL 1001
+QP+ + V + A L
Sbjct: 202 CCKQPDGVLAVFKKRAAEL 220
>UniRef50_Q2GD55 Cluster: Folylpolyglutamate synthase; n=1;
Neorickettsia sennetsu str. Miyayama|Rep:
Folylpolyglutamate synthase - Neorickettsia sennetsu
(strain Miyayama)
Length = 442
Score = 126 bits (303), Expect = 1e-27
Identities = 72/180 (40%), Positives = 102/180 (56%), Gaps = 1/180 (0%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+HVAGT GKGST A +IL+ G+ Y+SPHL ER+ L R IS+ K+ +
Sbjct: 49 VIHVAGTNGKGSTIAFLRAILQASGYSVNVYTSPHLRYFNERIVLRNREISD----KFLY 104
Query: 657 DVHQRLEDTQ-KFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
DV LED + +G+ +F T+ A F + D +++E G+GG +D TN+ K
Sbjct: 105 DV---LEDVRIASQGEKLTFFEGTTLAAILAFSRSNADFSLIETGMGGRLDATNVFPKPI 161
Query: 834 VVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
ITA+ DHTS LG TI +IA KAGI+K G +Q EA+D++ A S + P+
Sbjct: 162 ATIITAIDFDHTSYLGATIAQIAYEKAGIIKEGVPCVVARQHGEAIDIIQGVAKSKRVPV 221
>UniRef50_A7HDB5 Cluster: FolC bifunctional protein; n=2;
Anaeromyxobacter|Rep: FolC bifunctional protein -
Anaeromyxobacter sp. Fw109-5
Length = 403
Score = 126 bits (303), Expect = 1e-27
Identities = 72/171 (42%), Positives = 95/171 (55%), Gaps = 3/171 (1%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+HV GT GKGST AM + L G G Y+SPHLV ER+++ G I +D A
Sbjct: 39 VLHVGGTNGKGSTCAMAAAALAAAGHEVGLYTSPHLVRFNERIQVRGAAIGDDELAAVVE 98
Query: 657 DVHQRLE-DTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
++ + EGD YF F T+ F + V A+VEVG+GG D TN + VP
Sbjct: 99 EIRRACPWHDGGGEGDRLTYFEFATLAGLLHFARAGVGAAVVEVGLGGRFDATNAI--VP 156
Query: 834 -VVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYT-VQQPNEAMDVL 980
V I A+GLDHT +LG+T++ IA KAGI K G A +QP A++ L
Sbjct: 157 RVTAIAAIGLDHTQLLGDTVERIAVEKAGIFKPGVPAVVHGRQPPAALEAL 207
>UniRef50_A4VSD9 Cluster: Folylpolyglutamate synthase; n=2;
Streptococcus suis|Rep: Folylpolyglutamate synthase -
Streptococcus suis (strain 05ZYH33)
Length = 408
Score = 126 bits (303), Expect = 1e-27
Identities = 67/179 (37%), Positives = 103/179 (57%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+HVAGT GKGST A + + HG R G + SPH+V+V +R+ ++ + IS+ F Y
Sbjct: 39 VIHVAGTNGKGSTIAFMRKLFQAHGMRVGSFVSPHMVSVHDRICIDSQPISDHDFQHYLQ 98
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V+ LE + +YF + ++ + F ++ DVA+VEVGIGGL+D TN++
Sbjct: 99 KVYD-LEQEIATRYEPFRYFEVMVLIMFLYFEAQQPDVALVEVGIGGLLDTTNVVAPALS 157
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
V IT++G+DH +LG+T++EIA KAGI+K E + Q A + P+
Sbjct: 158 V-ITSIGMDHQDLLGSTLREIAEQKAGIIKESVPVVLGPLSPETTAICRQIAQDNQAPV 215
>UniRef50_A0UYZ7 Cluster: FolC bifunctional protein; n=1;
Clostridium cellulolyticum H10|Rep: FolC bifunctional
protein - Clostridium cellulolyticum H10
Length = 424
Score = 126 bits (303), Expect = 1e-27
Identities = 61/171 (35%), Positives = 97/171 (56%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
+L +H+AGT GKGST+A SIL G+RTG ++SP++ ER++++ IS D A+
Sbjct: 38 KLKFIHIAGTNGKGSTTAFISSILIEAGYRTGMFTSPYIQRFTERIKVDNNEISNDELAE 97
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
+ +E + P F +T + F K+K D+ ++EVG+GG+VD TN++
Sbjct: 98 LISQIKNCIEKMVSNGFEHPTEFEIITAASMEYFYKKKCDIVVLEVGLGGIVDSTNVIDT 157
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
+T++ +DH LG T+ EIA KAGI+K+ Q EA +V+
Sbjct: 158 PEASVVTSISMDHMDRLGETLGEIAYQKAGIIKQDGVVVLYPQEQEAEEVI 208
>UniRef50_Q2LQC5 Cluster: Folylpolyglutamate synthase /
dihydrofolate synthase; n=1; Syntrophus aciditrophicus
SB|Rep: Folylpolyglutamate synthase / dihydrofolate
synthase - Syntrophus aciditrophicus (strain SB)
Length = 465
Score = 125 bits (302), Expect = 2e-27
Identities = 66/167 (39%), Positives = 99/167 (59%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
V + GT GKGST+A+ IL+ G++ G Y+SPHL ++ ER+R+NG +ISE+ F
Sbjct: 73 VLIGGTNGKGSTAAILSCILKESGYKVGLYTSPHLTSICERIRINGSLISEERMQDCFGM 132
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
+ LE+ YF LT AY F +EKVD+A++EVG+GG +D TN++ + V
Sbjct: 133 IQSSLEEPL-------TYFEVLTASAYLYFYQEKVDIAVLEVGMGGRLDATNVVTPLVSV 185
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
I+ + L+H LG +++IAA KAGI+K T +D+L
Sbjct: 186 -ISNVHLEHQEYLGRHLRDIAAEKAGIIKENSVCVTAVTQKAVLDLL 231
>UniRef50_Q0LMK1 Cluster: FolC bifunctional protein; n=1;
Herpetosiphon aurantiacus ATCC 23779|Rep: FolC
bifunctional protein - Herpetosiphon aurantiacus ATCC
23779
Length = 435
Score = 125 bits (302), Expect = 2e-27
Identities = 69/178 (38%), Positives = 101/178 (56%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
V VAGTKGKGST A ESI+R G + GF+SSPHL + RER+++N +IS+ +
Sbjct: 51 VIVAGTKGKGSTCAFLESIIRQSGLKVGFFSSPHLHSYRERMQINRELISQSQLVDLINQ 110
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
V LE G P + V+ F + +++A++E+G+GG D N + V V
Sbjct: 111 VRPLLEPLDPEVGS-PTTYEIGVVLGLYYFATQAIELAVLEIGLGGRYDAINTVNPVLSV 169
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
I ++ DHT+ILG+T+ +IA KAGI+K+ + Q EA +V+ Q A PL
Sbjct: 170 -IASISYDHTAILGDTLAKIAYEKAGIIKQHVPVISTVQQAEAAEVIAQVAAEQAAPL 226
>UniRef50_A5Z386 Cluster: Putative uncharacterized protein; n=1;
Eubacterium ventriosum ATCC 27560|Rep: Putative
uncharacterized protein - Eubacterium ventriosum ATCC
27560
Length = 462
Score = 125 bits (302), Expect = 2e-27
Identities = 73/214 (34%), Positives = 110/214 (51%), Gaps = 1/214 (0%)
Frame = +3
Query: 342 LQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSA 521
++ N S + K++ L ++ L R G + +EL VVH+AGT GKGS
Sbjct: 1 MEMNYSEAREYLKNVNKLGSILGLNTIKELLKRLG---NPQNELKVVHIAGTNGKGSIMT 57
Query: 522 MCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEG- 698
++IL G++ G Y SP + RE +R+N ISE+ A + ++ D+ EG
Sbjct: 58 FVQNILMESGYKVGRYCSPAVFNEREIIRINDEYISEEQSADLLTRIKEKC-DSMYSEGL 116
Query: 699 DMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSIL 878
P F T A F ++ D+A++E G+GG D TN+ KV I + LDHT L
Sbjct: 117 PHPTSFEIETAEALMFFKEQNCDIALIECGMGGETDATNVFEKVLCSVIATISLDHTQFL 176
Query: 879 GNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
G+TI+EI K+GI+K C +Q EA +V+
Sbjct: 177 GSTIEEITKVKSGIIKENCPVVMSKQTVEAENVI 210
>UniRef50_A5V1W9 Cluster: FolC bifunctional protein; n=2;
Roseiflexus|Rep: FolC bifunctional protein - Roseiflexus
sp. RS-1
Length = 453
Score = 125 bits (302), Expect = 2e-27
Identities = 69/181 (38%), Positives = 101/181 (55%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
V +AGTKGKGST+A+ E+I+R G RTG ++SPHL RER+++N ++ D +
Sbjct: 49 VIIAGTKGKGSTAALLEAIVRAAGLRTGLWTSPHLHTYRERIQVNRTPMTRDELVRAVES 108
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
+ +E P FA +A F + VD+AI+EVG+GG D ++ + V
Sbjct: 109 IQPVIESMMSGPVGAPVTFAIGFALALRYFAEHAVDLAILEVGVGGRFDSAAVVTPILSV 168
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTX 1019
IT + DH +LG+T+ +IA KAGIMK G + Q EA + LI+ A + PL
Sbjct: 169 -ITPISYDHMDLLGDTLAQIAWEKAGIMKPGVPVISAPQHPEARETLIRCAAEIGAPLYF 227
Query: 1020 V 1022
V
Sbjct: 228 V 228
>UniRef50_A4XL37 Cluster: FolC bifunctional protein; n=2;
Clostridiales|Rep: FolC bifunctional protein -
Caldicellulosiruptor saccharolyticus (strain ATCC 43494
/ DSM 8903)
Length = 431
Score = 125 bits (302), Expect = 2e-27
Identities = 73/210 (34%), Positives = 113/210 (53%), Gaps = 1/210 (0%)
Frame = +3
Query: 354 KSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCES 533
+ +E I + G K LE+++ L G + +L +VHVAGT GKGST A
Sbjct: 6 EEALEYIHGTYKFGVKL-GLENIKKLLELMG---NPQKDLRIVHVAGTNGKGSTCAFINQ 61
Query: 534 ILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKY 713
+L G++ G Y+SP+L ER+++N IS D A V +++ + P
Sbjct: 62 MLIEAGYKVGLYTSPYLEFFNERIKINNIPISNDELATITEFVKDKVDLMISQGFNHPTE 121
Query: 714 FAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQ 893
F +T +A+ F + VD ++EVG+GG D TN++ + IT++G DH ILG TI+
Sbjct: 122 FEIVTAIAFEYFKRTNVDFVVLEVGLGGRFDATNVVETPELCIITSIGYDHMDILGQTIE 181
Query: 894 EIAASKAGIMKRGCEAYT-VQQPNEAMDVL 980
+IA KAGI+K +Q+ EA+DV+
Sbjct: 182 QIAYEKAGIIKESSTVILGLQRYKEAIDVI 211
>UniRef50_Q1WT76 Cluster: Folylpolyglutamate synthase / Dihydrofolate
synthase; n=1; Lactobacillus salivarius subsp. salivarius
UCC118|Rep: Folylpolyglutamate synthase / Dihydrofolate
synthase - Lactobacillus salivarius subsp. salivarius
(strain UCC118)
Length = 433
Score = 125 bits (301), Expect = 3e-27
Identities = 69/209 (33%), Positives = 116/209 (55%), Gaps = 3/209 (1%)
Frame = +3
Query: 396 QKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSS 575
+K L+ M +++ R G + +++ +HV GT GKGST+A ++ G+ G ++S
Sbjct: 20 KKIPTLDRMRDFMKRLG---NPHEKVKAIHVTGTNGKGSTTAYLRDLIAEQGYNVGTFTS 76
Query: 576 PHLVAVRERVRLNGRVISEDMFAKYFH---DVHQRLEDTQKFEGDMPKYFAFLTVMAYNI 746
P + ER+ +NG++IS++ + + V + ++ + P F +T M +
Sbjct: 77 PFIEKFNERISVNGKMISDEEIVRLVNIIGPVVKEMDSDWRDREGGPTEFEIVTAMMFVY 136
Query: 747 FLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
F + VD A++EVGIGGL D TN++ + V IT + +DH ILG+TI +IA KAGI+K
Sbjct: 137 FAEGHVDYAVIEVGIGGLFDSTNVITPLMSV-ITTVAMDHAHILGDTIAKIATHKAGIIK 195
Query: 927 RGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
+ P+EA+ V+ Q A + PL
Sbjct: 196 YKKPILIGKLPDEAIKVVKQVAKEKEAPL 224
>UniRef50_A5ZW55 Cluster: Putative uncharacterized protein; n=1;
Ruminococcus obeum ATCC 29174|Rep: Putative
uncharacterized protein - Ruminococcus obeum ATCC 29174
Length = 433
Score = 125 bits (301), Expect = 3e-27
Identities = 71/175 (40%), Positives = 95/175 (54%), Gaps = 1/175 (0%)
Frame = +3
Query: 411 LEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVA 590
LE + L R G + + VVHVAGT GKGST A S+ R G+ G ++SPHLV
Sbjct: 22 LEHTKECLRRLG---NPQKQFQVVHVAGTNGKGSTCAFLTSVFREAGYSCGLFTSPHLVV 78
Query: 591 VRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDM-PKYFAFLTVMAYNIFLKEKVD 767
+ ER ++N + I D F + F V ++L D EG P YF FL +M IF VD
Sbjct: 79 INERFQINEKNIDNDTFLRAFEKV-KKLADELVAEGSYHPTYFEFLFLMGMVIFADANVD 137
Query: 768 VAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
I+E G+GG +D T + + IT++ DH LGNTI+ IA KA I+ G
Sbjct: 138 YVILETGLGGRLDATTAVEEPSACVITSISFDHMQYLGNTIEAIAGEKAEIIVPG 192
>UniRef50_A3TFM8 Cluster: Putative folylpolyglutamate synthase; n=1;
Janibacter sp. HTCC2649|Rep: Putative folylpolyglutamate
synthase - Janibacter sp. HTCC2649
Length = 466
Score = 124 bits (300), Expect = 3e-27
Identities = 69/173 (39%), Positives = 101/173 (58%), Gaps = 4/173 (2%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+H+ GT GK +T+ + ESILR G TG ++SPHL ++ ER+ + GR I + F + +
Sbjct: 64 VIHLTGTNGKTTTARVIESILREMGLTTGRFTSPHLHSMLERISIGGRPIEAEKFLRSYA 123
Query: 657 DVHQRLE--DTQKFEGDMPK--YFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
+V +E D + E D P+ YF L +AY F VDVAI+EVG+GG D TN+
Sbjct: 124 EVIPLIELVDARSAENDEPRMTYFEVLVAVAYAAFADAPVDVAIIEVGMGGSWDATNVAD 183
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLI 983
V V IT + LDH LGN + +IA K+GI+K G + Q + A+ ++
Sbjct: 184 GVVSV-ITPIALDHQHFLGNRVTDIALEKSGIIKAGGIVISADQGDPAVTAIL 235
>UniRef50_Q0GL77 Cluster: Folylpolyglutamate synthase; n=3;
Lactobacillus reuteri|Rep: Folylpolyglutamate synthase -
Lactobacillus reuteri
Length = 437
Score = 124 bits (299), Expect = 4e-27
Identities = 76/209 (36%), Positives = 111/209 (53%), Gaps = 3/209 (1%)
Frame = +3
Query: 396 QKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSS 575
+K L M+ +L+ G + + L +HV GT GKGST AM S L G G ++S
Sbjct: 19 KKIPTLTRMKRFLAELG---NPQEGLKYIHVTGTNGKGSTVAMMRSALLESGLTVGSFTS 75
Query: 576 PHLVAVRERVRLNGRVISED---MFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNI 746
P + ER+ NG IS+D + V ++L+DT + G P F T + +
Sbjct: 76 PFITRFNERIEYNGIPISDDDLLRLVQKIAPVVKKLDDTLETGG--PTEFEIDTALMFCY 133
Query: 747 FLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
++K DV ++EVGIGGL D TN++ V V IT +G DH LG+T+ +IAA KAGI+K
Sbjct: 134 MAEKKPDVILLEVGIGGLYDSTNVITPVVSV-ITTVGWDHMKYLGDTLAKIAAQKAGIIK 192
Query: 927 RGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
+G P EA + ++ A K P+
Sbjct: 193 KGVPVVLGALPTEARETILADAKEKKSPV 221
>UniRef50_A5CR24 Cluster: FolC protein; n=4; Actinobacteria
(class)|Rep: FolC protein - Clavibacter michiganensis
subsp. michiganensis (strain NCPPB 382)
Length = 524
Score = 124 bits (299), Expect = 4e-27
Identities = 70/177 (39%), Positives = 106/177 (59%), Gaps = 4/177 (2%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
+VHV GT GK STS M ESILR G RTG ++SPHLV ER+ ++G I+++ ++ +
Sbjct: 121 IVHVTGTNGKTSTSRMTESILRAAGLRTGLFTSPHLVRFNERIVVDGLPITDEALSRNWA 180
Query: 657 DVHQRLEDTQK---FEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
DV ++ + G+ P +F LTV+A+ F VDVA++EVG+GG D TN+
Sbjct: 181 DVEPFIDLVDRELVAAGEEPVTFFEALTVLAFAAFADAPVDVAVIEVGMGGEWDSTNV-G 239
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYAD 995
V T + LDHT LG+T+ EIA +K+GI+K + + Q + + L++ A+
Sbjct: 240 DGQVAVFTPVSLDHTQRLGSTVAEIARTKSGIVKPAADVVSSAQAPDVVAELVRAAE 296
>UniRef50_Q1D8V1 Cluster: Tetrahydrofolylpolyglutamate
synthase/dihydrofolate synthase; n=2;
Cystobacterineae|Rep: Tetrahydrofolylpolyglutamate
synthase/dihydrofolate synthase - Myxococcus xanthus
(strain DK 1622)
Length = 410
Score = 124 bits (298), Expect = 6e-27
Identities = 71/178 (39%), Positives = 99/178 (55%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+HVAGT GKGST AM + L G R G Y+SPHLV V ER+R++ IS+ F +
Sbjct: 21 LHVAGTNGKGSTCAMTAASLHAAGHRVGLYTSPHLVRVNERIRVDSEDISDADFGLRILE 80
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
V LE YF F TV+A F + +VDVA++E G+GG +D T V V
Sbjct: 81 V---LERYPSAVSSPMTYFEFGTVVALWHFAQVRVDVAVLETGLGGRLDATTAASPV-VT 136
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
IT + DH LG+T+ IA KAGI+K G +Q EA++ +++ A+ + P+
Sbjct: 137 AITPVSFDHMEYLGDTLAAIAGEKAGILKPGVPCVVARQAPEALEAILRKAEQVGAPV 194
>UniRef50_Q6DKZ3 Cluster: Dihydrofolate/folylpolyglutamate synthase;
n=1; Toxoplasma gondii|Rep:
Dihydrofolate/folylpolyglutamate synthase - Toxoplasma
gondii
Length = 553
Score = 124 bits (298), Expect = 6e-27
Identities = 61/157 (38%), Positives = 97/157 (61%)
Frame = +3
Query: 456 SKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISED 635
S D+ ++HVAGT GKG+T A + L G++ G Y+SPH+++ RER+R++ ++I E+
Sbjct: 40 SPQDDYDIIHVAGTNGKGTTCAKLAACLSLKGYKVGTYTSPHILSFRERIRVDSQMIPEE 99
Query: 636 MFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTN 815
+H V Q T K G +F T MA+ F +++VD A++E G+GG +D TN
Sbjct: 100 DVVSLYHRVTQ----TAKQMGVELTFFEVTTQMAFLYFSQQEVDWAVIETGLGGRLDATN 155
Query: 816 ILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
I+ IT++G DH ++LG+T+ IA KAG++K
Sbjct: 156 IVDSPRCTVITSIGWDHMNVLGDTLDRIAQEKAGVIK 192
>UniRef50_A5K2Z0 Cluster: Dihydrofolate synthase/folylpolyglutamate
synthase, putative; n=1; Plasmodium vivax|Rep:
Dihydrofolate synthase/folylpolyglutamate synthase,
putative - Plasmodium vivax
Length = 535
Score = 124 bits (298), Expect = 6e-27
Identities = 68/188 (36%), Positives = 104/188 (55%), Gaps = 1/188 (0%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
D +HVAGT GKGS L+ +R G ++SPH+ ++RER++++ ISE+
Sbjct: 45 DSYKTIHVAGTNGKGSVCHKISVSLKLRNYRVGLFTSPHVFSLRERIKVDDECISEEDLV 104
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
+V ++ ++ P +F +T++AY F + VD A+VE GIGG +D TNIL+
Sbjct: 105 SLVGEVWKKADELDL----KPSFFETVTIVAYLFFRAKGVDYAVVETGIGGRLDATNILK 160
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAM-DVLIQYADSL 1001
K +V IT++G DH +LG + +I K GI+KR V P+ ++ L A L
Sbjct: 161 KPDLVIITSIGYDHQQLLGTHLSDICEEKIGIIKRSTS--VVVGPSVSLYRSLFTRATDL 218
Query: 1002 KCPLTXVP 1025
C LT VP
Sbjct: 219 GCTLTVVP 226
>UniRef50_A1ZCQ8 Cluster: Folylpolyglutamate synthase; n=1;
Microscilla marina ATCC 23134|Rep: Folylpolyglutamate
synthase - Microscilla marina ATCC 23134
Length = 428
Score = 123 bits (297), Expect = 8e-27
Identities = 69/178 (38%), Positives = 102/178 (57%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+H+AGT GKGS+S M ++L+ G++ G Y+SPHL + ERVR+NG+ I+ +
Sbjct: 49 LHIAGTNGKGSSSHMLAAVLQAAGYKVGLYTSPHLKSFTERVRVNGQAIAPAQIVAFV-- 106
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
QR + TQ E P +F MA + F ++KVDVA++EVG+GG +D TNI+ +
Sbjct: 107 --QRYQ-TQ-IESWRPSFFEVTVAMALDYFAQQKVDVAVIEVGLGGRLDATNIVTPEACL 162
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
IT + DH ILGNT++ IA KAGI+K ++ E V + + PL
Sbjct: 163 -ITNISFDHQQILGNTLKAIAKEKAGIIKLNTPVVIGERQTETTPVFETTSQQHQAPL 219
>UniRef50_Q9U738 Cluster: Dihydrofolate synthase/folylpolyglutamate
synthase; n=6; Plasmodium|Rep: Dihydrofolate
synthase/folylpolyglutamate synthase - Plasmodium
falciparum
Length = 522
Score = 123 bits (297), Expect = 8e-27
Identities = 73/189 (38%), Positives = 110/189 (58%), Gaps = 2/189 (1%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
D+ +H+AGT GKGS + L+ F+ G +SSPH+ ++RER+ +N ISE
Sbjct: 93 DKYKTIHIAGTNGKGSVCYKIYTCLKIKKFKVGLFSSPHIFSLRERIIVNDEPISEK--- 149
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
+ H V++ L +K + P +F +T++A+ FL +KVD AI+E GIGG +D TNIL
Sbjct: 150 ELIHLVNEVLNKAKKLYIN-PSFFEIITLVAFLHFLNKKVDYAIIETGIGGRLDATNILT 208
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAM-DVLIQYADSL 1001
K V+ IT++G DH +ILG+ + I K GI K+ +A V P+ A+ + A L
Sbjct: 209 KPEVIVITSIGYDHLNILGDNLPIICNEKIGIFKK--DANVVIGPSVAIYKNVFDKAKEL 266
Query: 1002 KCPL-TXVP 1025
C + T VP
Sbjct: 267 NCTIHTVVP 275
>UniRef50_Q0AWF7 Cluster: Putative uncharacterized protein; n=1;
Syntrophomonas wolfei subsp. wolfei str. Goettingen|Rep:
Putative uncharacterized protein - Syntrophomonas wolfei
subsp. wolfei (strain Goettingen)
Length = 416
Score = 123 bits (296), Expect = 1e-26
Identities = 69/181 (38%), Positives = 100/181 (55%)
Frame = +3
Query: 471 LSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKY 650
L VH+AGT GKGSTS + ++L G+R G + SPH+ + RER +N I E+ F Y
Sbjct: 27 LKTVHIAGTNGKGSTSFILSAVLSQAGYRVGRFISPHIHSYRERFTINDTFIEEEEFLFY 86
Query: 651 FHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKV 830
V + +++ + P F LT +A F ++VD+AI EVG+GG+ D TN++ V
Sbjct: 87 MAQVKKHIKNLSQ----RPTEFEILTAIALEYFRDKQVDLAIFEVGMGGIYDSTNVIEPV 142
Query: 831 PVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCP 1010
V IT + DHT LG +++EIA +KAGI+K+ A V+ A L P
Sbjct: 143 VSV-ITGIDYDHTQYLGTSLEEIARNKAGIIKKKVPLVMGPVNPPARQVIAARARELDSP 201
Query: 1011 L 1013
L
Sbjct: 202 L 202
>UniRef50_Q38XD0 Cluster: Putative polylpolyglutamate synthase; n=1;
Lactobacillus sakei subsp. sakei 23K|Rep: Putative
polylpolyglutamate synthase - Lactobacillus sakei subsp.
sakei (strain 23K)
Length = 434
Score = 122 bits (295), Expect = 1e-26
Identities = 66/179 (36%), Positives = 101/179 (56%), Gaps = 1/179 (0%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+HV GT GKGS M S+L G + G Y+SP + ER+ ++ + I++D
Sbjct: 45 IHVTGTNGKGSVVNMVSSLLVELGLKVGRYTSPFITRFNERIAIDQQPIADDDLVAVTQH 104
Query: 660 VHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V Q +E Q+ + F +T + + F ++ VD+A++EVGIGGL D TN+L +
Sbjct: 105 VQQTIETVQQADTTFEVTEFELITAIMFTYFKQQAVDIAVIEVGIGGLYDSTNVLTPLIS 164
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
V IT++GLDH ++LG+T+ IA KAGI+K + P EA V+++ A L PL
Sbjct: 165 V-ITSVGLDHQALLGDTLAAIATQKAGIIKAQHPVVIGKLPAEAQTVIVETAKRLASPL 222
>UniRef50_Q4AKU0 Cluster: Folylpolyglutamate synthetase; n=1;
Chlorobium phaeobacteroides BS1|Rep: Folylpolyglutamate
synthetase - Chlorobium phaeobacteroides BS1
Length = 436
Score = 122 bits (295), Expect = 1e-26
Identities = 74/209 (35%), Positives = 116/209 (55%)
Frame = +3
Query: 387 RTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGF 566
R G K LE + + L+ G +L + VVH+AGT GKG+ + SI GF TG
Sbjct: 28 RFGMK-PGLERIRSLLNAVGNPQKRLGK--VVHIAGTNGKGTVAYAVASIFSSAGFTTGL 84
Query: 567 YSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNI 746
Y+SPHLV+ ER+ +NG I E A Y + + + D + +F T MA
Sbjct: 85 YTSPHLVSFTERICVNGCRIPEPQVAAYCDVLKEEVADRK------ATFFEVTTAMACMY 138
Query: 747 FLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
F + + +V+++E G+GG +D TN++ V+ I ++G DHT+ LG+T+++IAA KA I+K
Sbjct: 139 FAEMQAEVSVIETGMGGRLDATNVVDPDYVI-IPSIGKDHTAWLGDTVEKIAAEKAAIIK 197
Query: 927 RGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
+G YT + A+ +I A ++ L
Sbjct: 198 KGSRVYTAVKDPAALKPIIGRAAAVGATL 226
>UniRef50_Q2QLY6 Cluster: Dihydrofolate
synthetase/folylpolyglutamate synthetase, putative,
expressed; n=1; Oryza sativa (japonica
cultivar-group)|Rep: Dihydrofolate
synthetase/folylpolyglutamate synthetase, putative,
expressed - Oryza sativa subsp. japonica (Rice)
Length = 510
Score = 122 bits (295), Expect = 1e-26
Identities = 58/154 (37%), Positives = 96/154 (62%), Gaps = 4/154 (2%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRL--NGRVISEDMFAKYF 653
VH+AGTKGKGST+A +I+R G+ G Y+SPHL+ +RER+ + +G +S ++ F
Sbjct: 46 VHIAGTKGKGSTAAFLSNIMREQGYNVGCYTSPHLLTIRERISVGQSGGPVSAELLRDLF 105
Query: 654 HDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
+ + + + E +F T ++Y +F +E VD+AIVE G+GG D TN+++
Sbjct: 106 GHAKEAIGQSIESEDGALTHFEVFTALSYLLFSQENVDIAIVEAGLGGARDATNVIQSTE 165
Query: 834 VVG--ITALGLDHTSILGNTIQEIAASKAGIMKR 929
+ IT +G +H + LG ++Q IA +K+GI+K+
Sbjct: 166 LAASVITTVGKEHLAALGGSLQSIAVAKSGIIKQ 199
>UniRef50_P43775 Cluster: Folylpolyglutamate synthase; n=101;
Gammaproteobacteria|Rep: Folylpolyglutamate synthase -
Haemophilus influenzae
Length = 437
Score = 122 bits (294), Expect = 2e-26
Identities = 77/196 (39%), Positives = 108/196 (55%), Gaps = 4/196 (2%)
Frame = +3
Query: 432 LSRTGVTMSKLDELS----VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRE 599
L R KLD L V+ V GT GKG+T + E+IL +HG R G YSSPHL+ E
Sbjct: 31 LDRIKSVAEKLDLLHPVPYVITVGGTNGKGTTCRLLETILLNHGLRVGVYSSPHLLRYNE 90
Query: 600 RVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIV 779
RVR+ + + ++ F + D K E YF F T+ A ++F + K+DV I+
Sbjct: 91 RVRIQNQDLPDEAHTASFAFI-----DENKTES--LTYFEFSTLSALHLFKQAKLDVVIL 143
Query: 780 EVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQP 959
EVG+GG +D TNI+ V IT++ +DHT LG+T + IA KAGI + C + +P
Sbjct: 144 EVGLGGRLDATNIVDSHLAV-ITSIDIDHTDFLGDTREAIAFEKAGIFRENCPV-VIGEP 201
Query: 960 NEAMDVLIQYADSLKC 1007
N +L Q A+ L C
Sbjct: 202 NVPQTMLDQ-AEKLHC 216
>UniRef50_Q7MWW9 Cluster: Folylpolyglutamate synthase; n=2;
Bacteroidales|Rep: Folylpolyglutamate synthase -
Porphyromonas gingivalis (Bacteroides gingivalis)
Length = 429
Score = 122 bits (293), Expect = 2e-26
Identities = 62/151 (41%), Positives = 94/151 (62%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+HVAGT GKGST++ +IL+ G R G ++SPHLV RER+R+NG I+E+ +
Sbjct: 50 IHVAGTNGKGSTASTLAAILQVAGMRVGLFTSPHLVDFRERIRVNGICITEEYVVDFCER 109
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
+ + P +F T+MA++ F +VD+A++EVG+GG +D TNI+ + +
Sbjct: 110 TREMVTTLH------PSFFELTTMMAFDYFRHAQVDMALIEVGMGGRLDSTNIITPILSI 163
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRG 932
IT +G DH LG+T ++IA KAGI+K G
Sbjct: 164 -ITNIGKDHVQFLGDTPEKIAFEKAGIIKSG 193
>UniRef50_Q31PP5 Cluster: FolC bifunctional protein; n=2;
Synechococcus elongatus|Rep: FolC bifunctional protein -
Synechococcus sp. (strain PCC 7942) (Anacystis nidulans
R2)
Length = 412
Score = 122 bits (293), Expect = 2e-26
Identities = 64/180 (35%), Positives = 103/180 (57%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
+++ +VH+AGT GKGST A ++ LR +G+R G Y+SPHL++ ER++LNG+ +S D
Sbjct: 37 NQIPIVHIAGTNGKGSTCAFVDTALRANGYRVGRYTSPHLISWCERLQLNGQQVSSDRLL 96
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
+ V + D+ F LT + + +D+ ++E G+GG +D TN++
Sbjct: 97 EAVQTVLAAADGI-----DLTP-FELLTAAVWLVLADSDLDIVVIETGLGGRLDATNVVA 150
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLK 1004
+ V IT++G DH ++LG T+ IAA KAGI+K C EA V+ A+ L+
Sbjct: 151 QPLVTAITSIGHDHQAVLGPTLGAIAAEKAGIIKSRCPVVVGPLLPEARTVIRNRAEQLQ 210
>UniRef50_Q3DZP5 Cluster: Folylpolyglutamate synthetase; n=2;
Chloroflexus|Rep: Folylpolyglutamate synthetase -
Chloroflexus aurantiacus J-10-fl
Length = 438
Score = 122 bits (293), Expect = 2e-26
Identities = 71/182 (39%), Positives = 103/182 (56%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
+L+ V VAGTKGKGST A+ E++ R G R G ++SPHL + RER++++ IS+ +
Sbjct: 50 QLAAVVVAGTKGKGSTCALIEAMARAAGLRVGLWTSPHLSSYRERIQIDREPISQATLIQ 109
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
DV ++ P F VMA F+ VD+A+VEVG+GG D +
Sbjct: 110 LVRDVQPIVDAFDTATYGRPSTFDIGFVMAMRHFVAAHVDLAVVEVGLGGRFDAAATITP 169
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKC 1007
+ V I+++ DH +ILG T+ +IA +KAGIM+ G A TV Q EA V A ++
Sbjct: 170 LIAV-ISSISYDHMAILGPTLHDIAYNKAGIMRPGRPAITVPQHPEAAAVFAAEAQTVGA 228
Query: 1008 PL 1013
PL
Sbjct: 229 PL 230
>UniRef50_A3VQ98 Cluster: FolC bifunctional protein; n=1;
Parvularcula bermudensis HTCC2503|Rep: FolC bifunctional
protein - Parvularcula bermudensis HTCC2503
Length = 443
Score = 122 bits (293), Expect = 2e-26
Identities = 75/191 (39%), Positives = 103/191 (53%), Gaps = 1/191 (0%)
Frame = +3
Query: 411 LEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVA 590
L+ +E L+R G +L V+HVAGT GKGST A SIL+ G + ++SPHLV
Sbjct: 30 LDRIEEALARLGNPHHRLPP--VLHVAGTNGKGSTCAFLGSILKAAGLKVHIFTSPHLVR 87
Query: 591 VRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVD 767
ER+ L G IS+D+ A L + GD+P YF +T A+ F + D
Sbjct: 88 FNERITLAGEPISDDLLAA-------TLGRCEAAAGDLPLSYFEAVTASAFLAFAETAGD 140
Query: 768 VAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYT 947
V I+E G+GG +D TN++ IT + LDH LG + +IA KAGI+K G T
Sbjct: 141 VVILETGLGGRLDATNVIDHPRAAIITPIALDHQRFLGTELADIAFEKAGILKAGAAFVT 200
Query: 948 VQQPNEAMDVL 980
Q +EA+ VL
Sbjct: 201 GAQRHEALPVL 211
>UniRef50_Q6MAP9 Cluster: Putative folylpolyglutamate synthase; n=1;
Candidatus Protochlamydia amoebophila UWE25|Rep:
Putative folylpolyglutamate synthase - Protochlamydia
amoebophila (strain UWE25)
Length = 410
Score = 121 bits (292), Expect = 3e-26
Identities = 68/152 (44%), Positives = 96/152 (63%), Gaps = 1/152 (0%)
Frame = +3
Query: 474 SVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYF 653
S +HVAGT GKGS A S L + G+R G Y+SPH+ + RER+R+NG +ISE K
Sbjct: 41 SSIHVAGTNGKGSVVAKIASALEYAGYRVGVYTSPHISSFRERIRVNGIMISEADVEKI- 99
Query: 654 HDVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKV 830
+ Q T ++ +P +F T +A F +EKVD A++E G+GG +D TNI+ V
Sbjct: 100 --LSQLFNLTAQY--SIPATFFELTTFLALVYFSREKVDFAVLEAGLGGRLDATNIVSPV 155
Query: 831 PVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
+ IT++ LDHT ILG+T++ IA KAGI+K
Sbjct: 156 LSI-ITSISLDHTDILGDTLEAIAKEKAGIIK 186
>UniRef50_A1SMD5 Cluster: FolC bifunctional protein; n=5;
Actinomycetales|Rep: FolC bifunctional protein -
Nocardioides sp. (strain BAA-499 / JS614)
Length = 460
Score = 121 bits (292), Expect = 3e-26
Identities = 73/212 (34%), Positives = 110/212 (51%), Gaps = 1/212 (0%)
Frame = +3
Query: 360 TIEQIRKDIRTGQKCTNLE-DMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESI 536
T E++ + + T LE ++ + T V V+H+ GT GK STS M +++
Sbjct: 13 TFEEVEDALLSRWPETRLEPSLDRIRAFTEVLGDPQSGYPVIHLTGTNGKTSTSRMIDTL 72
Query: 537 LRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYF 716
LR RTG ++SPH+ + ER+ ++G +S++ F + F+DV E +F
Sbjct: 73 LRALDLRTGRFTSPHVERMTERISVDGEPLSDEEFVRAFNDVAPYTHLVDSSEDHPLSFF 132
Query: 717 AFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQE 896
+ MAY F VDVA+VEVG+GG D TN+ V + + +DH + LG T E
Sbjct: 133 ETVVGMAYAAFADAPVDVAVVEVGMGGSWDATNV-ADATVAVVLPVAVDHAAYLGETPAE 191
Query: 897 IAASKAGIMKRGCEAYTVQQPNEAMDVLIQYA 992
IA KAGI+K G A QQ + VL++ A
Sbjct: 192 IAVEKAGIIKPGSVAVLAQQAPDVARVLLERA 223
>UniRef50_Q8EPN5 Cluster: Folyl-polyglutamate synthase; n=1;
Oceanobacillus iheyensis|Rep: Folyl-polyglutamate
synthase - Oceanobacillus iheyensis
Length = 426
Score = 121 bits (291), Expect = 4e-26
Identities = 64/182 (35%), Positives = 106/182 (58%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
+L +H+AGT GKGSTS +S L + ++ G ++SP +R +++N +SE +F++
Sbjct: 38 DLPTIHIAGTNGKGSTSQFIQSALIANDYKVGSFTSPSFYGIRGFIQMNNEPVSEKVFSQ 97
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
F + +E K +G+ P F LTV+++ F + VD+A+VE G+GG+ D TN++
Sbjct: 98 AFQKMLPAIEMLDK-DGNSPSNFEILTVLSFVCF-ENNVDIAVVEAGMGGMWDTTNVISP 155
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKC 1007
+ V IT + DHT++LG T+ EIA KAGI+K T A D++ + + +
Sbjct: 156 IVTV-ITTISYDHTALLGETLVEIAEQKAGIIKPLIPMITGVN-GTAYDIIEKKTEEMNS 213
Query: 1008 PL 1013
PL
Sbjct: 214 PL 215
>UniRef50_Q40KD4 Cluster: Folylpolyglutamate synthetase; n=12;
Rickettsiales|Rep: Folylpolyglutamate synthetase -
Ehrlichia chaffeensis str. Sapulpa
Length = 435
Score = 120 bits (290), Expect = 6e-26
Identities = 76/199 (38%), Positives = 104/199 (52%), Gaps = 1/199 (0%)
Frame = +3
Query: 420 MENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRE 599
M L R G KL V+H+AGT GKGST + IL G +T Y+SPHLV E
Sbjct: 27 MRQLLDRLGNPEKKLPP--VIHIAGTNGKGSTISFIRYILNSAGLKTHIYTSPHLVEFNE 84
Query: 600 RVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIV 779
RV L G+ IS+ +Y H+V + + EG +F T F K D+ +V
Sbjct: 85 RVVLAGKRISD----QYLHEVIEICREAS--EGIPVTFFEGTTAAILLAFSKVDADIVLV 138
Query: 780 EVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQP 959
E G+GG +D TN++ + + IT++ L+HT LGNT++ IA KAGIMK Q
Sbjct: 139 ETGVGGRLDATNVVHPILNI-ITSISLEHTEALGNTVELIAGEKAGIMKENVTCVIAPQD 197
Query: 960 NEA-MDVLIQYADSLKCPL 1013
E+ M+VL +A PL
Sbjct: 198 QESIMNVLEYHAIKKNVPL 216
>UniRef50_Q1JY09 Cluster: FolC bifunctional protein; n=1;
Desulfuromonas acetoxidans DSM 684|Rep: FolC bifunctional
protein - Desulfuromonas acetoxidans DSM 684
Length = 430
Score = 120 bits (288), Expect = 1e-25
Identities = 68/179 (37%), Positives = 100/179 (55%), Gaps = 1/179 (0%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
+VHVAGT GKGS A I R G++ G Y+SPHL ER+R+NG+ I + H
Sbjct: 42 IVHVAGTNGKGSVCAFLGRIYRQAGYQVGVYTSPHLHRFNERIRVNGQPIDD-------H 94
Query: 657 DVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
D+ +++ ++ ++P +F F T +A F ++ VD+ I+EVG+GG +D TN++ +
Sbjct: 95 DLVALVDELRQKNSEVPATFFEFTTALALLYFARQNVDLVILEVGMGGRLDATNVVAPLV 154
Query: 834 VVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCP 1010
V IT + DH LG ++ EIAA K GI+K G Q AM VL A + P
Sbjct: 155 SV-ITPVSDDHGDYLGGSLAEIAAEKGGIIKPGVPVVIGPQDKAAMAVLSARAKEMAAP 212
>UniRef50_Q03EP1 Cluster: Folylpolyglutamate synthase; n=1;
Pediococcus pentosaceus ATCC 25745|Rep:
Folylpolyglutamate synthase - Pediococcus pentosaceus
(strain ATCC 25745 / 183-1w)
Length = 424
Score = 119 bits (287), Expect = 1e-25
Identities = 65/183 (35%), Positives = 97/183 (53%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
D + +HVAGT GKGST A ++ G R G ++SP+L ER+ +NG I +D
Sbjct: 37 DAIQGIHVAGTNGKGSTIAFLAKMMETTGQRVGTFTSPYLERFNERIAVNGIPIRDDEIL 96
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
++ +++ + P F +T M + F K VD+ ++EVGIGG D TN+
Sbjct: 97 TLVEEIKPIVDELDQTPLGGPLEFEIVTAMMFLYFKKHPVDIVLIEVGIGGRYDSTNVFT 156
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLK 1004
+ V IT +G DH ILG+T+ +IA KAGI+K T + A+ V+ + A L
Sbjct: 157 PIASV-ITNIGWDHMQILGDTLPKIAFQKAGIIKTNVPVITGTEDQAALRVIEEEAKKLH 215
Query: 1005 CPL 1013
PL
Sbjct: 216 APL 218
>UniRef50_A0LA36 Cluster: FolC bifunctional protein; n=2; cellular
organisms|Rep: FolC bifunctional protein - Magnetococcus
sp. (strain MC-1)
Length = 426
Score = 119 bits (287), Expect = 1e-25
Identities = 71/183 (38%), Positives = 102/183 (55%), Gaps = 4/183 (2%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
VVHVAGT GKGS A +ILR G Y+SPHLV + ER++ NG V ED +Y+
Sbjct: 47 VVHVAGTNGKGSVIAFFGAILRQAGRSVAAYTSPHLVTIHERIQYNG-VPVEDALLRYYA 105
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVD----VAIVEVGIGGLVDYTNILR 824
L +Q+ +F LT A+ + + V ++E G+GG +D TN+++
Sbjct: 106 QQVLALPQSQQ-----ATFFERLTATAFAVMAHWQASDPSLVVVLETGLGGRLDATNVVQ 160
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLK 1004
V + ITA+GLDH S LG ++ +IA KAGI+K G A +EA+ VL+Q A +
Sbjct: 161 PV-LTAITAMGLDHQSYLGTSMAQIAQEKAGILKAGVPAVLAPAQDEALAVLVQQAQQVG 219
Query: 1005 CPL 1013
P+
Sbjct: 220 APV 222
>UniRef50_Q88UX8 Cluster: Folylpolyglutamate synthase; n=2;
Lactobacillus|Rep: Folylpolyglutamate synthase -
Lactobacillus plantarum
Length = 444
Score = 119 bits (286), Expect = 2e-25
Identities = 73/209 (34%), Positives = 104/209 (49%), Gaps = 3/209 (1%)
Frame = +3
Query: 396 QKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSS 575
+K L M +L G K+ + +HVAGT GKGST A + G G ++S
Sbjct: 19 KKAPTLSRMRQFLHELGDPQLKV---AGIHVAGTNGKGSTVANLRELFMADGLTVGTFTS 75
Query: 576 PHLVAVRERVRLNGRVISEDMFAKYFHDVHQ---RLEDTQKFEGDMPKYFAFLTVMAYNI 746
P +V ER+ ++G IS++ + +L+ T G P F +T M +
Sbjct: 76 PFIVRFNERISVDGTPISDEELVGLVQQIQPIVAKLDATLASGG--PTEFEIITAMMFLY 133
Query: 747 FLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
F + +D+AI+EVG+GGL D TN+ V IT +G DH ILGNT+ IA KAGI+K
Sbjct: 134 FAAQPIDIAIIEVGLGGLYDSTNVWTPAVSV-ITTIGYDHMQILGNTLTAIATQKAGIIK 192
Query: 927 RGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
+ P EA V+I S + PL
Sbjct: 193 TQVPVIVGKLPAEAQQVMIDTTMSKRAPL 221
>UniRef50_Q5VAN8 Cluster: FolC; n=63; Alphaproteobacteria|Rep: FolC -
Rhizobium etli
Length = 450
Score = 118 bits (285), Expect = 2e-25
Identities = 75/207 (36%), Positives = 109/207 (52%), Gaps = 6/207 (2%)
Frame = +3
Query: 408 NLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLV 587
+L+ + L R G KL VVHVAGT GKGS +A C ++L G+ ++SPHLV
Sbjct: 30 SLDRITRLLDRLGNPHRKLPP--VVHVAGTNGKGSVTAFCRALLEAGGYSAHVHTSPHLV 87
Query: 588 AVRERVRLN-----GRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFL 752
ER R+ G+++ + +FA+ V + G F LT + + +F
Sbjct: 88 NWHERYRIGVAGGRGQLVDDAVFAEAVRRV------AEANAGQHITVFEILTAVTFILFS 141
Query: 753 KEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
+ D AI+EVG+GG D TN++ V I + LDH LG+ ++ IAA KAGIMK G
Sbjct: 142 EHPADAAIIEVGLGGRFDATNVISDPAVSVIMPISLDHQPYLGDRVELIAAEKAGIMKPG 201
Query: 933 CEAYT-VQQPNEAMDVLIQYADSLKCP 1010
Q+ + A+DVL+ A+ L CP
Sbjct: 202 LPVVIGHQEYDAALDVLMSTAERLHCP 228
>UniRef50_Q5KWL4 Cluster: Folyl-polyglutamate synthetase; n=16;
Bacillaceae|Rep: Folyl-polyglutamate synthetase -
Geobacillus kaustophilus
Length = 449
Score = 118 bits (284), Expect = 3e-25
Identities = 71/222 (31%), Positives = 119/222 (53%), Gaps = 1/222 (0%)
Frame = +3
Query: 342 LQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSA 521
+++ + + I +R G K L+ ME + + G ++ VH+ GT GKGST A
Sbjct: 2 VRTYEEAVAWIHGRLRLGMK-PGLKRMEWMMEQLGHPERRV---RAVHIGGTNGKGSTVA 57
Query: 522 MCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGD 701
SIL+ G+ G ++SP++ ER+ +NG+ I ++ + + ++ ++ E
Sbjct: 58 YLRSILQAAGYSVGTFTSPYVEQFNERISINGQPIRDEEIVELVQTIKPLADELEQTELG 117
Query: 702 MPKYFAFLTVMAYNIFLKEKV-DVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSIL 878
P F +T M F K+ + D+ ++EVG+GG +D TNI+ + V IT + DH +IL
Sbjct: 118 GPTEFEVITAMMLYYFGKQNIQDIVLIEVGLGGRLDSTNIIYPLLSV-ITNVSYDHMNIL 176
Query: 879 GNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLK 1004
G+T+ +IAA KAGI+K G T EA +V+ + A K
Sbjct: 177 GDTLDQIAAEKAGIIKSGIPLVTAVNEPEAWEVIAKTAAERK 218
>UniRef50_Q03Y79 Cluster: Folylpolyglutamate synthase; n=1;
Leuconostoc mesenteroides subsp. mesenteroides ATCC
8293|Rep: Folylpolyglutamate synthase - Leuconostoc
mesenteroides subsp. mesenteroides (strain ATCC 8293
/NCDO 523)
Length = 441
Score = 118 bits (284), Expect = 3e-25
Identities = 61/168 (36%), Positives = 99/168 (58%)
Frame = +3
Query: 471 LSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKY 650
L ++H+AGT GKGST M SIL+ +G+ G +SSP ++ RE++R+NG +IS+ F KY
Sbjct: 52 LKIIHIAGTNGKGSTGTMLGSILKANGYTYGHFSSPSIMDDREQIRINGEMISKSDFLKY 111
Query: 651 FHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKV 830
+ D L YF + T+++ F+ +KV++ I E G+GGL D TN +
Sbjct: 112 Y-DQLVVLFKHHNVPLYYLSYFEYFTIISLLAFVDKKVNLVIFETGLGGLWDATNAIEPP 170
Query: 831 PVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMD 974
+ T + +DH ++LG+ I EIA +KA I+K G + + P + ++
Sbjct: 171 MLTVFTKISIDHQNLLGHNIAEIAENKAAIIKPG--TWVIDYPGQDIE 216
>UniRef50_Q00X21 Cluster: Dihydrofolate synthetase
/folylpolyglutamate synthetase; n=2; Ostreococcus|Rep:
Dihydrofolate synthetase /folylpolyglutamate synthetase
- Ostreococcus tauri
Length = 483
Score = 118 bits (284), Expect = 3e-25
Identities = 65/175 (37%), Positives = 98/175 (56%), Gaps = 2/175 (1%)
Frame = +3
Query: 474 SVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYF 653
+ VHV+GTKGKG+T ++ S+LR G R G Y SPH+ V ER+R + S ++
Sbjct: 69 TTVHVSGTKGKGTTLSVLASVLRSAGKRVGTYKSPHVYTVAERIRSSDEDASTEVL-NLL 127
Query: 654 HDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR--K 827
+ V ++ QK E YF LT +A+ F K KVD+A+VEVG+GG D TN+LR
Sbjct: 128 NGVETEIKAAQKREDGQLSYFEVLTALAFAYFKKAKVDLALVEVGLGGSRDATNVLRPEN 187
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYA 992
+ IT +G +H + LG +I I +KAGI G + ++ + +++ A
Sbjct: 188 LEAAVITHIGEEHLAALGGSIDTIVDAKAGIAHEGRPVFYAPNADDKITQMLRRA 242
>UniRef50_Q8KFQ9 Cluster: Folylpolyglutamate synthase; n=1;
Chlorobaculum tepidum|Rep: Folylpolyglutamate synthase -
Chlorobium tepidum
Length = 392
Score = 118 bits (283), Expect = 4e-25
Identities = 67/182 (36%), Positives = 105/182 (57%), Gaps = 1/182 (0%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+HVAGT GKG+ ++ SI G +TG ++SPHLV ER+R++G+ I + A+Y
Sbjct: 1 MHVAGTNGKGTVASCVASIFSTSGRKTGLFTSPHLVDFTERIRIDGQQIGQARVAEYCTK 60
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
+ +E F F T MA+ F E VD A++E G+GG +D TN+++ +V
Sbjct: 61 LQPAVETGATF-------FETTTAMAFAFFADEGVDAAVIETGMGGRLDATNVVQP-EIV 112
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYT-VQQPNEAMDVLIQYADSLKCPLT 1016
I ++G+DHT LG +++EIAA KA I+KR +T V + EA + + A+++ L
Sbjct: 113 IIPSIGMDHTEWLGGSLREIAAEKAAIIKRCSRVFTAVPEAGEAFAPIREAAEAVGAELH 172
Query: 1017 XV 1022
V
Sbjct: 173 QV 174
>UniRef50_Q41DX5 Cluster: Folylpolyglutamate synthetase; n=1;
Exiguobacterium sibiricum 255-15|Rep: Folylpolyglutamate
synthetase - Exiguobacterium sibiricum 255-15
Length = 416
Score = 118 bits (283), Expect = 4e-25
Identities = 66/184 (35%), Positives = 102/184 (55%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
D + +HVAGT GKGST A + G + G ++SP+++ ER+ LNG ISE
Sbjct: 38 DAIPTIHVAGTNGKGSTVAFLREMGVAEGLQVGTFTSPYIIQFEERIMLNGVPISEADLV 97
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
+ + V + + G + ++ A LTV+A+ F + + D I EVG+GGL D TN+L+
Sbjct: 98 EAANVVQAAILKLEPVIGALTEFEA-LTVLAFYHFYQIRPDFVIYEVGLGGLYDSTNVLK 156
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLK 1004
+ IT++G DH +ILG+T+QEIA K GI+K+G + E L+ Y +
Sbjct: 157 QPKAAIITSIGHDHQAILGDTLQEIALQKFGIIKQGTRVIAGKLQEELTVPLMAYCGDRQ 216
Query: 1005 CPLT 1016
L+
Sbjct: 217 ASLS 220
>UniRef50_A3ESF6 Cluster: Folylpolyglutamate synthase; n=1;
Leptospirillum sp. Group II UBA|Rep: Folylpolyglutamate
synthase - Leptospirillum sp. Group II UBA
Length = 444
Score = 118 bits (283), Expect = 4e-25
Identities = 68/188 (36%), Positives = 107/188 (56%), Gaps = 1/188 (0%)
Frame = +3
Query: 411 LEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVA 590
L+ + LS G S D+ + + GT GKGSTS + + I R G RTG ++SPHL+
Sbjct: 25 LDSISKVLSELG---SPQDKFPAIQITGTNGKGSTSVILDLIYRRAGLRTGLFTSPHLLD 81
Query: 591 VRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDV 770
VRER+R++G ++ D+F + V E T G +F LT +++ +F ++D+
Sbjct: 82 VRERIRIDGTLVETDVFLEAMQSVCLAQEKT----GVTLTFFETLTAVSFLVFSLSRIDL 137
Query: 771 AIVEVGIGGLVDYTNILRKVPVVGI-TALGLDHTSILGNTIQEIAASKAGIMKRGCEAYT 947
A++EVG+GG D T++ VP V + T+L DHT ILG+T++ I KA I + G + +
Sbjct: 138 AVLEVGMGGRWDATSLC--VPEVSVLTSLAKDHTEILGDTLELILQEKAAIGRSG-KPFV 194
Query: 948 VQQPNEAM 971
P E +
Sbjct: 195 ATLPPEVL 202
>UniRef50_Q5FRN0 Cluster: Folylpolyglutamate synthase / dihydrofolate
synthase; n=2; Acetobacteraceae|Rep: Folylpolyglutamate
synthase / dihydrofolate synthase - Gluconobacter oxydans
(Gluconobacter suboxydans)
Length = 400
Score = 117 bits (282), Expect = 5e-25
Identities = 67/178 (37%), Positives = 94/178 (52%), Gaps = 1/178 (0%)
Frame = +3
Query: 492 GTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQR 671
G GKGST A +I G R SSPHLV+V ER RL GR++ ED+
Sbjct: 23 GRTGKGSTCANLRAIAEAGGLRVHVMSSPHLVSVTERFRLAGRLVDEDVLVA-------A 75
Query: 672 LEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGIT 848
LE ++ P F LT + +F + D+ ++EVG+GG +D TN++ K IT
Sbjct: 76 LEKVEQVNAGAPITVFEVLTAAGFLLFSQVPADLVVLEVGLGGRLDATNVVPKPAACVIT 135
Query: 849 ALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXV 1022
+ LDH + LG+T+ IA KAGI+K G + Q EA+DV+ + A L PL +
Sbjct: 136 PVSLDHEAFLGSTVAAIAGEKAGIIKEGVPVVSASQAPEALDVIRRRAAELNAPLRVI 193
>UniRef50_Q6M382 Cluster: FOLYLPOLYGLUTAMATE SYNTHASE; n=32;
Actinomycetales|Rep: FOLYLPOLYGLUTAMATE SYNTHASE -
Corynebacterium glutamicum (Brevibacterium flavum)
Length = 507
Score = 117 bits (282), Expect = 5e-25
Identities = 67/153 (43%), Positives = 89/153 (58%), Gaps = 4/153 (2%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+HVAGT GK ST+ M ES+LR RTG +SPHL V ER+ ++G+ I F + + +
Sbjct: 93 IHVAGTNGKTSTTRMIESLLRAFHRRTGRTTSPHLQLVTERIAIDGKPIHPRDFVRIYEE 152
Query: 660 VHQRLEDTQKFE----GDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
+ +E T + G F L +AY F VDVA+VEVG+GG D TN++
Sbjct: 153 IKPYMEMTDAWSEAEGGPKMSKFEALVALAYAGFADAPVDVAVVEVGLGGRWDATNVINA 212
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
V IT +G+DH LGNTI EIA KAGI+K
Sbjct: 213 AVSV-ITPVGMDHVDRLGNTIGEIAGEKAGIIK 244
>UniRef50_Q5SLF0 Cluster: Folyl-polyglutamate synthetase; n=4;
Deinococci|Rep: Folyl-polyglutamate synthetase - Thermus
thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length = 414
Score = 117 bits (281), Expect = 7e-25
Identities = 74/209 (35%), Positives = 109/209 (52%)
Frame = +3
Query: 387 RTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGF 566
R G+ LE + +L+R G + V V GT GKG+T+ +IL GFR G
Sbjct: 10 RQGRFAPGLERIRAFLARLG---HPEEAYPVALVGGTNGKGTTARALAAILEEAGFRVGL 66
Query: 567 YSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNI 746
Y+SPHLV RER+++ GR I E+ ++ E + +F T +A
Sbjct: 67 YTSPHLVDFRERIQVQGRPIPEEKLLALLAELRPHAERLE------ASFFEVATALALLH 120
Query: 747 FLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
F +E V+ A++EVG+GG +D TN V V +T +G DH +LG T++++A KAGI +
Sbjct: 121 FAREGVEFAVLEVGLGGRLDATNATEPVLSV-VTNVGHDHLEVLGPTLKDVAREKAGIFR 179
Query: 927 RGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
G A T + E + VL A + K PL
Sbjct: 180 GGVPALTAAR-GEGLGVLRAEALARKTPL 207
>UniRef50_Q30WU4 Cluster: FolC bifunctional protein; n=1;
Desulfovibrio desulfuricans G20|Rep: FolC bifunctional
protein - Desulfovibrio desulfuricans (strain G20)
Length = 435
Score = 117 bits (281), Expect = 7e-25
Identities = 65/183 (35%), Positives = 100/183 (54%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
E VV V GT GKGST+ SI GF TG + SPH + RERV ++G ++ E+ +
Sbjct: 55 EYPVVQVVGTNGKGSTATFMASIATGAGFSTGLFISPHFITPRERVLVDGEMLPEEDWLV 114
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
+D+ G++ YF FLTV+A F +VD+A+ E G+GG D T +
Sbjct: 115 LANDI-------MAAGGEVLTYFEFLTVLAALAFADYEVDLAVFEAGLGGTYDATTAIAA 167
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKC 1007
VV T + LDH ILG+T+++IAA KAG ++ + +Q + +++L +++
Sbjct: 168 DTVV-FTPVALDHQQILGDTVEKIAADKAGAIRSNVPVVSARQTDAVLEILKNASNTAGA 226
Query: 1008 PLT 1016
P T
Sbjct: 227 PFT 229
>UniRef50_Q9HS44 Cluster: Dihydropteroate synthase; n=4;
Halobacteriaceae|Rep: Dihydropteroate synthase -
Halobacterium salinarium (Halobacterium halobium)
Length = 815
Score = 117 bits (281), Expect = 7e-25
Identities = 64/175 (36%), Positives = 99/175 (56%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
V +AG+ GKGST+ ESILR G G Y+SPH VRERV +NGR +S+ +
Sbjct: 43 VQIAGSNGKGSTARFTESILRAAGLDVGLYTSPHFDDVRERVTVNGRRMSKAALTTFIET 102
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
+ + + + +G P YF +T MA F + VDVA++EVGIGG +D T+++
Sbjct: 103 ITPYVTE-RAADGAAPTYFEVVTAMALWQFSRADVDVAVLEVGIGGRLDATSVV-DPSAS 160
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLK 1004
+T++ L+HT +LG TI EIA KA + G ++A+ + +A +++
Sbjct: 161 AVTSVTLEHTDVLGETIPEIARDKAHVAPAGDTPLVTATTDDALAAVRDHAGAVR 215
>UniRef50_Q8UJA7 Cluster: Folylpolyglutamate synthase; n=2;
Agrobacterium tumefaciens str. C58|Rep:
Folylpolyglutamate synthase - Agrobacterium tumefaciens
(strain C58 / ATCC 33970)
Length = 459
Score = 116 bits (279), Expect = 1e-24
Identities = 73/206 (35%), Positives = 109/206 (52%), Gaps = 6/206 (2%)
Frame = +3
Query: 408 NLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLV 587
+L+ + L + G +++ V+HVAGT GKGS SA C ++L G ++ PHLV
Sbjct: 39 SLDRISRLLEKLGNPQNRMPP--VIHVAGTNGKGSVSAFCRALLEAAGLPVHVHTKPHLV 96
Query: 588 AVRERVRLN-----GRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFL 752
ER RL GR + + +FA D +R+E +G F LT + + +F
Sbjct: 97 NWHERYRLGVAGERGRFVEDAVFA----DALRRIEVAN--DGQKITVFEILTAVMFLLFS 150
Query: 753 KEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
+ D AIVEVG+GG D TN++ V I + LDH + LG+ ++ IAA KAGIMK+G
Sbjct: 151 EHPADAAIVEVGLGGRFDATNVINSPAVSIIMPISLDHEAYLGDRVELIAAEKAGIMKKG 210
Query: 933 CEAYT-VQQPNEAMDVLIQYADSLKC 1007
Q+ + A + L+ A+ L C
Sbjct: 211 SPVVIGHQEYDAARETLVATAERLGC 236
>UniRef50_P73842 Cluster: Folyl-polyglutamate synthetase; n=10;
Cyanobacteria|Rep: Folyl-polyglutamate synthetase -
Synechocystis sp. (strain PCC 6803)
Length = 428
Score = 116 bits (279), Expect = 1e-24
Identities = 72/216 (33%), Positives = 105/216 (48%)
Frame = +3
Query: 363 IEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILR 542
I + + +T LE + L++ G +K+ VHV GT GKGS A S+L
Sbjct: 3 INTLLEPYKTAGVNLGLERIHGLLAKLGNPQAKVP---YVHVGGTNGKGSVCAYLSSVLA 59
Query: 543 HHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAF 722
G++ G Y+SPHL+ RERV L+ R I + A + Q D P F
Sbjct: 60 EAGYKVGRYTSPHLIDWRERVWLDNRFIDD---ASLIGALQQVTAIAPADSSDRPTLFEV 116
Query: 723 LTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIA 902
T + F + +VD+A++EVG+GG +D TN+ + IT+L +H +LG T+ IA
Sbjct: 117 FTAAVWLYFAQAEVDIAVMEVGLGGRLDATNVPEPCLLSIITSLSREHWQVLGPTVAHIA 176
Query: 903 ASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCP 1010
KAGI+K + P EA V + L CP
Sbjct: 177 REKAGILKAQRPVFLGNIPPEAQAVFQERIAELHCP 212
>UniRef50_Q11KL3 Cluster: FolC bifunctional protein; n=4;
Rhizobiales|Rep: FolC bifunctional protein -
Mesorhizobium sp. (strain BNC1)
Length = 440
Score = 116 bits (278), Expect = 2e-24
Identities = 73/206 (35%), Positives = 109/206 (52%), Gaps = 5/206 (2%)
Frame = +3
Query: 408 NLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLV 587
+LE + L R G KL V+H+AGT GKGS +A ++L G ++SPHLV
Sbjct: 22 SLERVGRLLQRLGDPQEKLPP--VIHIAGTNGKGSAAAFSRALLEASGRTVHVHTSPHLV 79
Query: 588 AVRERVRLN----GRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLK 755
ER RL G + +D+ A D +R+ + + G+ F LT + + +F +
Sbjct: 80 RWHERFRLGKPTGGEFVDDDVLA----DAVERVAEANR--GEQITVFEILTAVMFVLFSE 133
Query: 756 EKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGC 935
D A+VEVG+GG D TN++R I + LDH + LG+ ++ IAA KAGI+K G
Sbjct: 134 HPADAAVVEVGLGGRFDATNVIRHPATSLIMPISLDHEAYLGDRVELIAAEKAGIIKPGS 193
Query: 936 EAYTVQQP-NEAMDVLIQYADSLKCP 1010
QQ + A +VL++ A+ L P
Sbjct: 194 PVVIGQQEWDAAREVLLETAERLDVP 219
>UniRef50_A7HJX6 Cluster: FolC bifunctional protein; n=2;
Thermotogaceae|Rep: FolC bifunctional protein -
Fervidobacterium nodosum Rt17-B1
Length = 435
Score = 116 bits (278), Expect = 2e-24
Identities = 64/168 (38%), Positives = 95/168 (56%), Gaps = 2/168 (1%)
Frame = +3
Query: 483 HVAGTKGKGSTSAMCESILRHHGFR-TGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
HV G+ GKGS + E++ +HG TGFYS PHL + ER N +I+++ F
Sbjct: 47 HVTGSNGKGSVTTFLENLTYYHGHNVTGFYS-PHLSTILERFHWNTNLINQEEFVDAAEY 105
Query: 660 VHQRLEDTQKF-EGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V + E+ K E P +F ++T M +++ + + VEVG+GG D TN++ V
Sbjct: 106 VKKYAEEMDKIGEEFSPSFFEYMTAMYFHLTKVKNAEFGSVEVGLGGRFDSTNVITPVVS 165
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
V IT + L+HT++LGNT +EIA KAGI+K G + P EA V+
Sbjct: 166 V-ITTISLEHTNVLGNTHEEIAFEKAGIIKSGVPVVIGEMPEEAKIVI 212
>UniRef50_Q3A6L0 Cluster: Folylpolyglutamate synthetase; dihydrofolate
synthetase; n=1; Pelobacter carbinolicus DSM 2380|Rep:
Folylpolyglutamate synthetase; dihydrofolate synthetase -
Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 1)
Length = 422
Score = 115 bits (277), Expect = 2e-24
Identities = 67/182 (36%), Positives = 99/182 (54%), Gaps = 1/182 (0%)
Frame = +3
Query: 471 LSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKY 650
+ +VHVAGT GKGS SA IL+ G+RTG Y+SPHL + ER+R++G +SE
Sbjct: 39 MRIVHVAGTNGKGSVSAATALILQTAGYRTGLYTSPHLHSFTERIRIDGVQVSEP----- 93
Query: 651 FHDVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
D+ +++ + G +P +F F T MA F D A++EVG+GG +D TN +
Sbjct: 94 --DMVSLVDEVRAVVGSLPVTFFEFTTAMALVYFRNRHTDFAVLEVGMGGRLDATNAVES 151
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKC 1007
+ +T + DH LG + IA KAGI+KR +Q +A VL+ A +
Sbjct: 152 -EISVVTPVCCDHAEHLGADLATIAGEKAGIIKRQVPVVIAEQHPDAQRVLLTKAAEMLA 210
Query: 1008 PL 1013
P+
Sbjct: 211 PV 212
>UniRef50_Q12D50 Cluster: FolC bifunctional protein; n=1;
Polaromonas sp. JS666|Rep: FolC bifunctional protein -
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 501
Score = 115 bits (277), Expect = 2e-24
Identities = 71/171 (41%), Positives = 95/171 (55%), Gaps = 3/171 (1%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVI-SEDMFAKYF 653
V+ VAGT GKGST AM E+IL G+RTG Y+SPHLV ER R+ G ++ + D+ A +
Sbjct: 53 VITVAGTNGKGSTCAMLEAILLEAGYRTGVYTSPHLVHFEERCRVRGDIVNATDLVANF- 111
Query: 654 HDVHQRLEDTQKFEGD--MPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
R+E + GD YF F T+ + K+DV I+EVG+GG +D NIL
Sbjct: 112 ----ARVEAARVQNGDEISLTYFEFTTLAILQLLADAKLDVVILEVGLGGRLDAVNILDT 167
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
V IT++ LDH LGN + I KAGIM+ G + V P +L
Sbjct: 168 DCAV-ITSIDLDHMEFLGNDRESIGREKAGIMRAG-KPVVVSDPVPPQSIL 216
>UniRef50_A5GRK4 Cluster: FolC bifunctional protein; n=2;
Synechococcus|Rep: FolC bifunctional protein -
Synechococcus sp. (strain RCC307)
Length = 400
Score = 115 bits (277), Expect = 2e-24
Identities = 68/181 (37%), Positives = 97/181 (53%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
V VAGT GKGS +IL+ G + G Y SPHL++ ER+ + + I+ A+
Sbjct: 45 VQVAGTNGKGSICTALGAILQAAGLKAGLYRSPHLISWCERIAIGNQWIA----AEQLRS 100
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
+ QR + + P F LT A + F +VD+A++EVG+GG +D T PV+
Sbjct: 101 LLQRWQSLGQQHQLTP--FELLTAAAMDHFAAAQVDLAVLEVGLGGRLDATTCHPNRPVL 158
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTX 1019
GI +GLDH LG+T++ IA KAGI G A++ QP+ +VL Q A C L
Sbjct: 159 GIANIGLDHREHLGSTLEAIATEKAGIFHTGAVAFSAPQPDSVAEVLEQQAQQRGCQLHW 218
Query: 1020 V 1022
V
Sbjct: 219 V 219
>UniRef50_A3IEY3 Cluster: FolC; n=1; Bacillus sp. B14905|Rep: FolC -
Bacillus sp. B14905
Length = 416
Score = 115 bits (277), Expect = 2e-24
Identities = 65/185 (35%), Positives = 105/185 (56%), Gaps = 1/185 (0%)
Frame = +3
Query: 471 LSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKY 650
L VVH+AGT GKGST E+I + H R G + SP +V V ++++++G+ I+E
Sbjct: 41 LHVVHLAGTNGKGSTLTFLEAIAKEHELRVGKFMSPCIVDVHDQIQIDGQPITEADMDAV 100
Query: 651 FHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKV 830
F +H G + F LTV+A+ F+ ++VD++++E G+GGL+D TN++
Sbjct: 101 FRQMH-----AAGLSGKLTD-FELLTVVAFLYFVNKEVDISLMEAGMGGLLDSTNVV--T 152
Query: 831 PVVG-ITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKC 1007
P+V I ++ L+HT LG+TI IA KAGI+K+ P +A V+ + A K
Sbjct: 153 PIVSIIPSIALEHTKFLGDTIDSIARHKAGIIKQNRPVIIGNLPEDAKRVVYEEASHKKA 212
Query: 1008 PLTXV 1022
+ +
Sbjct: 213 AVLEI 217
>UniRef50_Q2HAU4 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 338
Score = 115 bits (277), Expect = 2e-24
Identities = 60/151 (39%), Positives = 92/151 (60%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+HVAGT GKGS A ++L G ++SPHL+ + + ++G+ +SE +F D
Sbjct: 23 IHVAGTNGKGSICAYLSTMLTASGLSHARFTSPHLIDRWDCIAIDGKPVSEAVF----RD 78
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
+ ++ K + F LT A+ IF ++KV+ +VEVG+GG +D TN+L++ V
Sbjct: 79 AEEVVKQRDKEDRIGATEFELLTATAFEIFHRQKVEYGVVEVGLGGKLDATNVLKQKAVS 138
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRG 932
I+ +GLDH S LGNTI+EIA KAGI++ G
Sbjct: 139 IISKIGLDHQSFLGNTIEEIALQKAGIIRPG 169
>UniRef50_Q5WEQ5 Cluster: Folylpolyglutamate synthase; n=1; Bacillus
clausii KSM-K16|Rep: Folylpolyglutamate synthase -
Bacillus clausii (strain KSM-K16)
Length = 436
Score = 115 bits (276), Expect = 3e-24
Identities = 67/182 (36%), Positives = 101/182 (55%), Gaps = 1/182 (0%)
Frame = +3
Query: 471 LSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKY 650
L+ VHVAGT GKGST + IL GF G ++SP++ ER+ +NG IS+ +
Sbjct: 42 LTAVHVAGTNGKGSTVSFLRHILTAGGFSVGTFTSPYIEQFSERISVNGVPISDRDLLQA 101
Query: 651 FHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLK-EKVDVAIVEVGIGGLVDYTNILRK 827
+ +E+ + + P F LT M + F + K D+ ++EVG+GG +D TN++
Sbjct: 102 AQRLKPIVEEVAQSDLGSPTEFEVLTAMMFYHFAEVAKPDICLIEVGLGGRLDSTNVVTP 161
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKC 1007
V + IT +G DH ILG+T+ EIA KAGI+K G + + EA V+ + A +
Sbjct: 162 VLSI-ITMIGHDHMHILGHTLAEIAYEKAGIIKPGIPVISGVEGEEAYTVISETARQIGS 220
Query: 1008 PL 1013
PL
Sbjct: 221 PL 222
>UniRef50_O67833 Cluster: Folylpolyglutamate synthetase; n=1;
Aquifex aeolicus|Rep: Folylpolyglutamate synthetase -
Aquifex aeolicus
Length = 410
Score = 115 bits (276), Expect = 3e-24
Identities = 63/149 (42%), Positives = 90/149 (60%)
Frame = +3
Query: 486 VAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVH 665
V GT GKGST A E ILR HGF+TG++ SPHL++ ER R+NG+ I E++ Y D+
Sbjct: 41 VGGTNGKGSTCAFTERILREHGFKTGWFVSPHLISENERWRINGKPIQEEVLKDYVKDLK 100
Query: 666 QRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGI 845
+ E KF YF T++A F + ++VA+ EVG+GG D T + + V GI
Sbjct: 101 KVFE---KFS---LTYFEAATLIAVKYFEDQGINVAVFEVGMGGRWDATKV-SEAGVRGI 153
Query: 846 TALGLDHTSILGNTIQEIAASKAGIMKRG 932
T + DHT LG+T+++IA K G+ + G
Sbjct: 154 TNVERDHTRWLGDTVEKIAEEKLGLYEEG 182
>UniRef50_Q7VRV1 Cluster: Folylpolyglutamate synthase; n=2; Candidatus
Blochmannia|Rep: Folylpolyglutamate synthase -
Blochmannia floridanus
Length = 415
Score = 114 bits (275), Expect = 4e-24
Identities = 70/180 (38%), Positives = 104/180 (57%), Gaps = 2/180 (1%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
E+ V V GT GKG+T + ESIL H + G Y+SPHL+ ER+R+ G+V+S+D+
Sbjct: 41 EIYTVLVGGTNGKGTTCFLLESILLHSDIKVGLYTSPHLLFYNERIRVCGQVLSDDV--- 97
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
+ + Q G YF F+T+ A IF K ++DV I+EVG+GG +D TN++
Sbjct: 98 ---HIQAMIAIEQVRSGVKLTYFEFITLSALYIFKKFQLDVVILEVGLGGRLDATNVV-D 153
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIM--KRGCEAYTVQQPNEAMDVLIQYADSL 1001
V IT + +DHT ILG T +IA KAGI K+ ++ +P +D +I+Y S+
Sbjct: 154 PDVSVITNIEMDHTDILGTTHNDIAIEKAGIFRAKKPVIFGSINRPC-VIDKIIKYQKSV 212
>UniRef50_O83360 Cluster: Folylpolyglutamate synthetase; n=1;
Treponema pallidum|Rep: Folylpolyglutamate synthetase -
Treponema pallidum
Length = 490
Score = 114 bits (275), Expect = 4e-24
Identities = 61/183 (33%), Positives = 101/183 (55%), Gaps = 1/183 (0%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+HVAGTKGKGS++ M +IL GF TG Y+SPH++ RER+ G S +A
Sbjct: 85 IHVAGTKGKGSSARMLAAILNEIGFNTGLYASPHVMDPRERITRAGVFFSPAEYASACTH 144
Query: 660 VHQRLEDTQKF-EGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V+ ++ T+ + +F +T++A+ +F +++++ ++ EVG+GG +D TNI+ +
Sbjct: 145 VYHTVKKTENLRDYGQATWFELITLLAFMLFAQQRMEWSVFEVGLGGRLDATNIICP-SI 203
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLT 1016
+ + +HT ILG I+ IA K GI+K + QP +A+ V A P
Sbjct: 204 CLLLPIEQEHTRILGTRIKSIAKEKGGIIKPYTPIFCFDQPEDALHVFKHIAREKHAPFF 263
Query: 1017 XVP 1025
+P
Sbjct: 264 YLP 266
>UniRef50_Q2VIK1 Cluster: Dihydrofolate synthase; n=1; Pneumocystis
carinii|Rep: Dihydrofolate synthase - Pneumocystis
carinii
Length = 424
Score = 114 bits (274), Expect = 5e-24
Identities = 64/180 (35%), Positives = 99/180 (55%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
+ VHVAGT GKGS A S L G R G Y SPHL+ + V++ GR I + F
Sbjct: 22 NSFQAVHVAGTNGKGSVCAYLSSCLALSGIRVGQYCSPHLIDRWDCVKVIGRDIDKHQFL 81
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
++ ++++ + F +T +A+ I K V++A++E G+GG +D TN+L
Sbjct: 82 ----EIESKIKNLNQRCNIGATEFEIMTAVAFEILSKNNVELAVIETGVGGRLDATNVLS 137
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLK 1004
+V + IT + +DH +LGNTIQ+IA K+GIMK+ V NE + + +S+K
Sbjct: 138 QVLLTIITKISMDHQELLGNTIQKIAREKSGIMKKNIPC-IVDGTNEDSVLKVIKEESIK 196
>UniRef50_Q74AI6 Cluster: FolC bifunctional protein; n=5;
Geobacter|Rep: FolC bifunctional protein - Geobacter
sulfurreducens
Length = 381
Score = 113 bits (272), Expect = 8e-24
Identities = 70/176 (39%), Positives = 93/176 (52%)
Frame = +3
Query: 486 VAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVH 665
+AGT GKGST+A SIL G+R G ++SPHL ER R+NG I+E+ A+ V
Sbjct: 1 MAGTNGKGSTAAFLASILAEGGYRAGLFTSPHLTRFTERFRINGTEIAEEAAARVAGQVL 60
Query: 666 QRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGI 845
+ F F +T MA F++E VD AI+E G+GG D T+ + V I
Sbjct: 61 ASAPEGTTF-------FEVVTAMALLHFVEEGVDAAILEAGMGGGADATSAATGILTV-I 112
Query: 846 TALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
+ LDH LG TI IA KAG+++ G +QP EA DV I+ L PL
Sbjct: 113 APVALDHCEWLGETIPAIAREKAGLIRAGRPVVLSRQPAEARDVFIERGRILGAPL 168
>UniRef50_Q6FEE4 Cluster: Bifunctional protein [Includes:
folylpolyglutamate synthase (FPGS); dihydrofolate
synthase ]; n=3; Acinetobacter|Rep: Bifunctional protein
[Includes: folylpolyglutamate synthase (FPGS);
dihydrofolate synthase ] - Acinetobacter sp. (strain
ADP1)
Length = 428
Score = 113 bits (272), Expect = 8e-24
Identities = 67/172 (38%), Positives = 97/172 (56%)
Frame = +3
Query: 411 LEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVA 590
LE + + GVT + V VAGT GKGST+ SIL G+R G Y SPH+
Sbjct: 31 LERVIPVAEKLGVTQTSA---KVFTVAGTNGKGSTTTTLASILTEQGYRVGLYQSPHIYR 87
Query: 591 VRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDV 770
ERV+LNG+ S+ + F V Q ++ G +F T+ A+ IF ++ D+
Sbjct: 88 FNERVKLNGQEASDQQLIEAFVKVDQ----VRRECGLSLSFFEATTLAAFLIFQQQACDI 143
Query: 771 AIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
++EVG+GG +D N++ V IT +GLDHT LG+TI++IA KAGI++
Sbjct: 144 WVLEVGLGGRLDVVNVI-DPDVAVITNIGLDHTDWLGDTIEKIAFEKAGIIR 194
>UniRef50_Q67SJ1 Cluster: Folylpolyglutamate synthase; n=1;
Symbiobacterium thermophilum|Rep: Folylpolyglutamate
synthase - Symbiobacterium thermophilum
Length = 437
Score = 113 bits (272), Expect = 8e-24
Identities = 68/182 (37%), Positives = 95/182 (52%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
VVH+ GT GKGS +AM E+ LR G R G Y+SP L+ +ER+++N I E A+
Sbjct: 42 VVHITGTSGKGSVAAMVEAGLRAAGRRVGLYTSPPLMRFKERMQVNRAEIPEADVARLTA 101
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V + E + P F +T MA F ++ VD ++E G+GG D T + K V
Sbjct: 102 RVAEAAEAVIAAGLEPPTEFEVITAMALAWFAEQSVDDLVLEAGMGGRFDATTAVEKAAV 161
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLT 1016
IT +GLDHT LG T + IA KAG+++ G T A+ V+ + A PL
Sbjct: 162 TAITNVGLDHTQWLGQTHEAIAWDKAGVIRPGVPCVTGTDHPGALAVIERVAREQGAPLL 221
Query: 1017 XV 1022
V
Sbjct: 222 HV 223
>UniRef50_Q31HH1 Cluster: FolC bifunctional folylpolyglutamate
synthase/dihydrofolate synthase; n=1; Thiomicrospira
crunogena XCL-2|Rep: FolC bifunctional folylpolyglutamate
synthase/dihydrofolate synthase - Thiomicrospira
crunogena (strain XCL-2)
Length = 425
Score = 113 bits (272), Expect = 8e-24
Identities = 65/179 (36%), Positives = 97/179 (54%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ VAGT GKGS+ AM SI G++ G Y+SPHL+ ER+R+ G++ + + F
Sbjct: 47 VISVAGTNGKGSSVAMLSSIYEASGYQVGVYTSPHLLHFNERIRVQGQLADDQQIVQAFA 106
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
+ T+ YF F T+ A +F + +DV ++EVG+GG +D N++
Sbjct: 107 AIEAARGQTKL------TYFEFSTLAALWVFAQHALDVILLEVGLGGRLDAVNLV-DADA 159
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
ITA+G+DH LG+ +IA KAGIM+ G T+ N+ + LI YA PL
Sbjct: 160 SLITAIGVDHEDWLGSDRNQIAVEKAGIMRSG--KPTICSDNDIPETLISYASQHNVPL 216
>UniRef50_A4B0Z4 Cluster: Bifunctional folylpolyglutamate
synthase/dihydrofolate synthase; n=1; Alteromonas
macleodii 'Deep ecotype'|Rep: Bifunctional
folylpolyglutamate synthase/dihydrofolate synthase -
Alteromonas macleodii 'Deep ecotype'
Length = 443
Score = 113 bits (272), Expect = 8e-24
Identities = 68/162 (41%), Positives = 91/162 (56%), Gaps = 2/162 (1%)
Frame = +3
Query: 462 LDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMF 641
L + V+ VAGT GKG+T + E + G YSSPHL RERVR NG + + F
Sbjct: 61 LSQSLVITVAGTNGKGTTCRLLEQAMLSQGKSVAVYSSPHLTDYRERVRYNGELPPANEF 120
Query: 642 AKYFHDVHQRLEDTQKFEGD--MPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTN 815
K F V + ++T EGD YF F T+ A + +VDV I+EVG+GG +D TN
Sbjct: 121 VKAFEFVEKSRKET---EGDPITLTYFEFGTLAAMKMMQSWEVDVVILEVGLGGRLDATN 177
Query: 816 ILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEA 941
I+ + IT + LDH LGNT ++IA KAGIM++ A
Sbjct: 178 IIHPDLAI-ITTIDLDHQDWLGNTREKIAREKAGIMRKNGNA 218
>UniRef50_Q68WJ9 Cluster: Folylpolyglutamate synthase; n=11;
Rickettsieae|Rep: Folylpolyglutamate synthase -
Rickettsia typhi
Length = 433
Score = 113 bits (271), Expect = 1e-23
Identities = 61/150 (40%), Positives = 90/150 (60%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+H+AGT GKGS+SAM +SI G++ Y+SPHL+ ER+ + G IS++ +
Sbjct: 39 VIHIAGTNGKGSSSAMLKSIFTVAGYKVHCYTSPHLLEFNERIIVAGEKISDNALWQVCE 98
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
H R+ ++KF + +F T A+ F + K D+ I+E G+GG +D TNI +
Sbjct: 99 --HVRIV-SEKFNIEA-SFFEGTTAAAFLAFAQTKADILILETGLGGRLDATNIFEHPLI 154
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMK 926
IT + DH ++LGNT+Q IA KAGIMK
Sbjct: 155 TLITPISYDHMNVLGNTLQMIAVEKAGIMK 184
>UniRef50_A5TUM3 Cluster: Tetrahydrofolate synthase; n=3;
Fusobacterium nucleatum|Rep: Tetrahydrofolate synthase -
Fusobacterium nucleatum subsp. polymorphum ATCC 10953
Length = 415
Score = 113 bits (271), Expect = 1e-23
Identities = 63/162 (38%), Positives = 92/162 (56%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+H+ GT GKGS S E IL G++ G Y+SPH++ ER+ N + IS++ AKY+
Sbjct: 45 VIHITGTNGKGSVSTTVERILLDAGYKVGKYTSPHILKFNERIIFNDKYISDENVAKYYE 104
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V +++ D + +F T M ++ F K D I+E G+GG D TN+ +
Sbjct: 105 RV-KKIIDEHNIQA---TFFEVTTAMMFDYFKDMKADYVILEAGMGGRYDATNVCDNIVS 160
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPN 962
V IT + L+HT LG+TI +IA KAGI+K C YT+ N
Sbjct: 161 V-ITNVSLEHTEYLGDTIYKIAKEKAGIIK-NC-PYTIFADN 199
>UniRef50_A4A847 Cluster: Folylpolyglutamate synthase/dihydrofolate
synthase; n=1; Congregibacter litoralis KT71|Rep:
Folylpolyglutamate synthase/dihydrofolate synthase -
Congregibacter litoralis KT71
Length = 428
Score = 113 bits (271), Expect = 1e-23
Identities = 64/153 (41%), Positives = 92/153 (60%), Gaps = 1/153 (0%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ VAGT GKGS E ILR HG RTG Y+SPHL++ ER+ ++G +S+ F
Sbjct: 44 VITVAGTNGKGSVVFGTECILRAHGRRTGRYTSPHLLSFNERIAVDGCPVSDGQIVAAFD 103
Query: 657 DVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
+ + GD+ YF F T+ AY IF + +VDVA++EVG+GG +D N++
Sbjct: 104 AI-------EAARGDVTLTYFEFATLAAYWIFRELRVDVAVMEVGLGGRLDAVNLVDS-D 155
Query: 834 VVGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
+ ITA+ LDH LG+T+++IA KA I + G
Sbjct: 156 IAVITAIDLDHQHWLGDTVEQIAPEKAAIARPG 188
>UniRef50_Q6B7M6 Cluster: FolC-P protein; n=1; Haloferax
volcanii|Rep: FolC-P protein - Halobacterium volcanii
(Haloferax volcanii)
Length = 838
Score = 113 bits (271), Expect = 1e-23
Identities = 70/204 (34%), Positives = 112/204 (54%)
Frame = +3
Query: 381 DIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRT 560
D+R Q E + LS G + +S V VAG+ GKGST+ M +++LR G
Sbjct: 12 DLRRFQVKPGTESIRRLLSHLG---DPHEGVSFVQVAGSNGKGSTARMVDAMLRESGAHV 68
Query: 561 GFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAY 740
G Y+SPH VRERVR++GR I + + + + L + + +G+ +F +T +A
Sbjct: 69 GLYTSPHFDDVRERVRVDGRKIPKSALSAFVAEAKPYLVE-RAADGEPLTFFETVTALAL 127
Query: 741 NIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGI 920
F + VDVA++EVG+GG +D T+ + V +T + L+HT++LG+T+ EIA +KA +
Sbjct: 128 WYFDRAGVDVAVLEVGMGGELDATSAVDPV-ASAVTNVSLEHTAVLGDTVAEIAKTKAAV 186
Query: 921 MKRGCEAYTVQQPNEAMDVLIQYA 992
T EA+ V+ + A
Sbjct: 187 APADAPLVT-GTTGEALSVIREEA 209
>UniRef50_Q38WN1 Cluster: Folylpolyglutamate synthase; n=1;
Lactobacillus sakei subsp. sakei 23K|Rep:
Folylpolyglutamate synthase - Lactobacillus sakei subsp.
sakei (strain 23K)
Length = 435
Score = 112 bits (270), Expect = 1e-23
Identities = 62/181 (34%), Positives = 100/181 (55%), Gaps = 1/181 (0%)
Frame = +3
Query: 474 SVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYF 653
S++HV GT GKGSTSAM +IL+ G+ G ++SPH++AV E +++N ++IS+ F +
Sbjct: 39 SIIHVCGTNGKGSTSAMIAAILQASGYSVGLFTSPHIMAVEESIQINRQLISKAQFERLL 98
Query: 654 HDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
V L+ YF L ++A F +++VD + E G+GG +D TN + +V
Sbjct: 99 ATVQTVLKKLGFDPTTDLSYFETLVLVALVYFKQQQVDYVLWECGLGGELDATNAVDRVA 158
Query: 834 VVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTV-QQPNEAMDVLIQYADSLKCP 1010
T + LDH ++LG+TI+ IA +K+ I++ +Q + VL A P
Sbjct: 159 YTLFTKISLDHMALLGDTIEAIATTKSKIIRPQTPVIVAPEQTKTTLHVLQAEAGRQSAP 218
Query: 1011 L 1013
L
Sbjct: 219 L 219
>UniRef50_Q9FN53 Cluster: Folylpolyglutamate synthase-like protein;
n=1; Arabidopsis thaliana|Rep: Folylpolyglutamate
synthase-like protein - Arabidopsis thaliana (Mouse-ear
cress)
Length = 480
Score = 112 bits (270), Expect = 1e-23
Identities = 55/129 (42%), Positives = 80/129 (62%), Gaps = 2/129 (1%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
VVHVAGTKGKGSTSA +ILR G+ G YSSPH+++++ER+ NG +S F+
Sbjct: 77 VVHVAGTKGKGSTSAFLSNILRAGGYSVGCYSSPHILSIKERISCNGEPVSASTLNDLFY 136
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V LE + + E +F LT +A+++F KE VD+A++E G+GG D TN++ +
Sbjct: 137 SVKPILEQSIQEENGSLSHFEILTGIAFSLFEKENVDIAVIEAGLGGARDATNVIESSNL 196
Query: 837 VG--ITALG 857
IT +G
Sbjct: 197 AASVITTIG 205
>UniRef50_Q5QWH7 Cluster: Folylpolyglutamate synthase; n=2;
Idiomarina|Rep: Folylpolyglutamate synthase - Idiomarina
loihiensis
Length = 430
Score = 112 bits (269), Expect = 2e-23
Identities = 60/152 (39%), Positives = 88/152 (57%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ V+GT GKGST E+IL+ G+ TG Y+SPH+ RERVR+N + + + K FH
Sbjct: 53 VITVSGTNGKGSTVCYLETILQAAGYTTGVYTSPHITEYRERVRVNAQELPDSEHVKAFH 112
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
+ Q +T YF F T+ A + ++ DVAI+EVG+GG +D N + V
Sbjct: 113 AIEQARNNTSL------TYFEFGTLAALWLMGRQSPDVAILEVGLGGRLDAVNCV-DADV 165
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
+T++G+DH + LGN + I KAGI + G
Sbjct: 166 AVVTSIGIDHIAFLGNNREHIGYEKAGIARSG 197
>UniRef50_Q83G53 Cluster: Folylpolyglutamate synthase; n=2; Tropheryma
whipplei|Rep: Folylpolyglutamate synthase - Tropheryma
whipplei (strain Twist) (Whipple's bacillus)
Length = 461
Score = 111 bits (268), Expect = 3e-23
Identities = 61/179 (34%), Positives = 98/179 (54%), Gaps = 4/179 (2%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+H+ GT GK + S M IL G R G ++SPH+ A+ ER++++ + + K++
Sbjct: 40 VIHITGTNGKTTVSRMIACILTSLGLRVGLFTSPHITALEERIQIDMNPVQGHILEKHWF 99
Query: 657 DV--HQRLEDTQKFEGDMP--KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
D+ RL D + + P +F +TV+A++ F VDV ++EVG+GG D TN++
Sbjct: 100 DIQFQLRLADAHLEKKNCPPLTFFECMTVLAFSCFADTPVDVMVLEVGMGGAWDATNVV- 158
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSL 1001
V T + DHT LG+ ++EIA +KAGI+K G +Q + L Y S+
Sbjct: 159 DARVCVFTPIDFDHTGRLGSRLEEIARTKAGIIKPGSFVVAAEQHQVVQECLEDYFASI 217
>UniRef50_A5WDG9 Cluster: FolC bifunctional protein; n=3;
Psychrobacter|Rep: FolC bifunctional protein -
Psychrobacter sp. PRwf-1
Length = 451
Score = 111 bits (267), Expect = 3e-23
Identities = 59/166 (35%), Positives = 95/166 (57%), Gaps = 1/166 (0%)
Frame = +3
Query: 438 RTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNG 617
R G+ S ++ V VAGT GKGST+A+ ++ + G++T Y SPHL+ ERVR++G
Sbjct: 45 RLGLVKSAKEDAYVFMVAGTNGKGSTTAVISAVCQQAGYKTALYQSPHLIDFNERVRIDG 104
Query: 618 RVISEDMFAKYFHDVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIG 794
+ + + + F+ V Q + D+ +F T+ A IF + DV ++EVG+G
Sbjct: 105 KPVGDQVLIDAFYQVEQ-----ARLACDLTLSFFEMTTLAAMLIFAEAHCDVWVLEVGLG 159
Query: 795 GLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
G +D NI+ + IT +G+DH LG+T ++I KAGI++ G
Sbjct: 160 GRLDVVNII-DADLAVITNIGIDHVDWLGDTREKIGFEKAGILREG 204
>UniRef50_A6D0N3 Cluster: Folylpolyglutamate synthase; n=1; Vibrio
shilonii AK1|Rep: Folylpolyglutamate synthase - Vibrio
shilonii AK1
Length = 426
Score = 111 bits (266), Expect = 4e-23
Identities = 67/178 (37%), Positives = 100/178 (56%), Gaps = 1/178 (0%)
Frame = +3
Query: 474 SVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYF 653
+V+ VAGT GKGST A+ E+IL G+ G YSSPHL+ ERVR+NG + ++ + F
Sbjct: 50 TVITVAGTNGKGSTCALMEAILLDAGYSVGVYSSPHLIRYNERVRVNGSDLPDESHTRAF 109
Query: 654 HDVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKV 830
+ +K G++ +F + T+ A F + KV+V ++EVG+GG +D TN++
Sbjct: 110 DYI-------EKLRGEVSLSFFEYATLAALRQFQENKVEVVLLEVGLGGRLDATNVVDH- 161
Query: 831 PVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLK 1004
V IT+L +DH LG+ I I KAGI + G A Q A + +AD +K
Sbjct: 162 DVSVITSLAVDHVDWLGDDINVIGFEKAGIFRTGKPAICGQPKPPA--TVPAHADDIK 217
>UniRef50_A1K4B2 Cluster: Dihydrofolate synthase /
Tetrahydrofolylpolyglutamate synthase; n=5;
Betaproteobacteria|Rep: Dihydrofolate synthase /
Tetrahydrofolylpolyglutamate synthase - Azoarcus sp.
(strain BH72)
Length = 432
Score = 111 bits (266), Expect = 4e-23
Identities = 61/156 (39%), Positives = 89/156 (57%), Gaps = 1/156 (0%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
E V+ V GT GKGST AM E+ILR G+R G Y+SPHL+ ERVR++G+ + +
Sbjct: 41 ETVVITVGGTNGKGSTCAMLEAILRAEGYRVGCYTSPHLLRYNERVRVDGQDVDDARLVA 100
Query: 648 YFHDVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
F E ++ GD+P YF T+ A+ +F DV I+EVG+GG +D N+
Sbjct: 101 GF-------EAVERARGDVPLTYFEHGTLAAWEVFRAAAPDVVILEVGLGGRLDAVNVFE 153
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
+ +T++ +DH LG+T + I KAGI + G
Sbjct: 154 PDCAI-VTSVAMDHMDYLGDTREAIGYEKAGIFRSG 188
>UniRef50_Q6BKI0 Cluster: Debaryomyces hansenii chromosome F of
strain CBS767 of Debaryomyces hansenii; n=2;
Saccharomycetaceae|Rep: Debaryomyces hansenii chromosome
F of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 449
Score = 111 bits (266), Expect = 4e-23
Identities = 73/184 (39%), Positives = 101/184 (54%), Gaps = 13/184 (7%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+H+AGT GKGST A SIL R G ++SPH+V + + +N V F K D
Sbjct: 28 IHIAGTNGKGSTVAYLSSILTQAKVRNGRFTSPHMVYYNDSICINNEVYPLAKF-KSISD 86
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK---- 827
Q+ E+T G F LTV A+ IF E+V++AI+EVG+GG +D TN+L
Sbjct: 87 YVQK-ENTSLRLGCTE--FELLTVTAFKIFELERVELAIIEVGLGGRLDATNVLESFIDD 143
Query: 828 --------VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQ-PNEAMDVL 980
V GIT +G+DH ++LG+T+ IA KAGIMK+ +Q EA+DVL
Sbjct: 144 RTTGHKGGVIATGITKIGIDHEALLGDTLAAIAYEKAGIMKKSVSCVVDRQNDQEALDVL 203
Query: 981 IQYA 992
+ A
Sbjct: 204 KKVA 207
>UniRef50_A1CXV3 Cluster: Dihydrofolate synthetase Fol3; n=11;
Pezizomycotina|Rep: Dihydrofolate synthetase Fol3 -
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / NRRL
181)(Aspergillus fischerianus (strain ATCC 1020 / DSM
3700 / NRRL 181))
Length = 424
Score = 111 bits (266), Expect = 4e-23
Identities = 60/151 (39%), Positives = 87/151 (57%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+H+AGT GKGS SA +L G R G ++SPHL+ + + + V+ E +F K
Sbjct: 23 IHIAGTNGKGSISAYLSHMLTAGGVRCGRFTSPHLIDRWDCITIGESVVQESLFRK---- 78
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
+ +R+ + G F LT A+ IF E V+V +VEVG+GG +D TN+L V V
Sbjct: 79 IEERVRLRDQSLGIGASEFELLTATAFEIFNHEHVEVGVVEVGMGGRLDATNVLSDVLVS 138
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRG 932
I +GLDH + LG+T++ I KAGI+K G
Sbjct: 139 IIAKIGLDHQAFLGDTLELITREKAGILKPG 169
>UniRef50_Q88ST5 Cluster: Folylpolyglutamate synthase; n=1;
Lactobacillus plantarum|Rep: Folylpolyglutamate synthase
- Lactobacillus plantarum
Length = 454
Score = 110 bits (265), Expect = 6e-23
Identities = 65/169 (38%), Positives = 96/169 (56%), Gaps = 1/169 (0%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+H+AGT GKGST AM SILR G++ G +SSP + RE+++ NG IS F +
Sbjct: 48 VIHIAGTNGKGSTGAMLASILRAQGYQVGRFSSPAINDAREQLQCNGTWISPAEFIDTYR 107
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
++ L++ D+ F + +++ F + V A++E G+GGL D TN L +
Sbjct: 108 EILPVLQNMGLTASDV-SIFEWFFLISVVWFRNQNVQWAVIEAGLGGLYDATNALASPQL 166
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTV-QQPNEAMDVL 980
T + LDHT+ILG TI IA +K+ I+K A T+ Q EA+ VL
Sbjct: 167 TVFTKIALDHTAILGPTITAIAQNKSKIIKPHTTAVTLADQHPEALAVL 215
>UniRef50_Q5FKW4 Cluster: Folylpolyglutamate synthase; n=6;
Lactobacillus|Rep: Folylpolyglutamate synthase -
Lactobacillus acidophilus
Length = 423
Score = 110 bits (265), Expect = 6e-23
Identities = 59/184 (32%), Positives = 100/184 (54%), Gaps = 1/184 (0%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
+++ +H+ GT GKGSTS ++L+ G +TG + SP++ ER++L+ + IS+
Sbjct: 40 NQVKTIHITGTNGKGSTSYYLSNLLKKAGQKTGLFVSPYVYRFNERIQLDNQDISDQDLI 99
Query: 645 KYFHDVHQRLEDTQKFEGDMPKY-FAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNIL 821
+ V + E+ Q+ + F + +A+ F ++K D A++EVGIGG D TN++
Sbjct: 100 VVANIVQKAYEELQEEDSAFSLVTFEYEVALAFVYFAQKKCDYAVIEVGIGGEHDKTNVI 159
Query: 822 RKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSL 1001
+ IT +GLDH I+G TIQ+IA K+G++K P + +L Q A
Sbjct: 160 MPEASI-ITTIGLDHEQIIGPTIQDIAREKSGVIKHNRPVILGNIPKNVLPILEQKAKIE 218
Query: 1002 KCPL 1013
P+
Sbjct: 219 DAPI 222
>UniRef50_A4BHC7 Cluster: FolC bifunctional folylpolyglutamate
synthase/dihydrofolate synthase; n=1; Reinekea sp.
MED297|Rep: FolC bifunctional folylpolyglutamate
synthase/dihydrofolate synthase - Reinekea sp. MED297
Length = 401
Score = 110 bits (265), Expect = 6e-23
Identities = 56/167 (33%), Positives = 93/167 (55%)
Frame = +3
Query: 432 LSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRL 611
L R + + +V+ VAGT GKG+TSA ++ + G + G Y+SPHL ER+R+
Sbjct: 29 LKRVATELLQKTPPTVMTVAGTNGKGTTSAAIAALCQSAGAKVGLYTSPHLFRFNERIRI 88
Query: 612 NGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGI 791
N +++ + + F V Q D YF + T+ A+ +F E++D ++E+G+
Sbjct: 89 NNEPVADQLLVEAFQAVEQARGDVSL------SYFEYTTLAAFWVFEHEQLDAWVLEIGL 142
Query: 792 GGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
GG +D N++ + +T +GLDH LG+T++EI KAGI + G
Sbjct: 143 GGRLDAVNLI-DPDIAVVTNVGLDHQGFLGDTLEEIGREKAGICRTG 188
>UniRef50_A4QWG8 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 406
Score = 110 bits (264), Expect = 8e-23
Identities = 63/176 (35%), Positives = 94/176 (53%), Gaps = 2/176 (1%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRH-HGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
VHVAGT GKGS A ++L G+ G ++SPH++ + + LN R + FA
Sbjct: 24 VHVAGTNGKGSICAYISALLTQVGGYSVGRFNSPHMIDRWDCITLNERTVHSSTFAAAEK 83
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
DV +R + + F L+ A+++F VD +VEVG+GG D TN+L V
Sbjct: 84 DVLRRNDQLNIGASE----FELLSATAFDLFRSSGVDFGVVEVGLGGRDDATNVLENKAV 139
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYT-VQQPNEAMDVLIQYADSL 1001
I+ +GLDH S LGNT+ +I+ KAGIM++G P +D + +A S+
Sbjct: 140 TVISKIGLDHQSFLGNTLADISLHKAGIMRQGVPCVVDASNPPTVLDAIHSHAKSV 195
>UniRef50_Q1MS38 Cluster: Folylpolyglutamate synthase; n=1; Lawsonia
intracellularis PHE/MN1-00|Rep: Folylpolyglutamate
synthase - Lawsonia intracellularis (strain PHE/MN1-00)
Length = 435
Score = 109 bits (263), Expect = 1e-22
Identities = 71/197 (36%), Positives = 105/197 (53%), Gaps = 5/197 (2%)
Frame = +3
Query: 432 LSRTGVTMSKLDELS----VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRE 599
L+R ++KLD S VV + GT GKGST+ S+ + HG + G Y+SPH V RE
Sbjct: 25 LTRMNQALTKLDFNSLPYKVVQIVGTNGKGSTATFLASLAKSHGLKVGIYTSPHFVTPRE 84
Query: 600 RVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIV 779
R+ +NG ++S +++ + L++T YF LTV+A F + KVD+AI+
Sbjct: 85 RICINGEMLSPEVWITLTERI---LDNTLSL-----TYFELLTVLAIVAFSEFKVDLAIL 136
Query: 780 EVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK-RGCEAYTVQQ 956
E G+GG D T + +V T + LDH LG+T++ IA K+ M+ R + QQ
Sbjct: 137 EAGLGGQHDATTAV-PADLVCYTPIDLDHEQFLGSTVEAIAKEKSQAMRFRKPVLSSFQQ 195
Query: 957 PNEAMDVLIQYADSLKC 1007
P E M +L A C
Sbjct: 196 P-EVMSILCAMAKEKNC 211
>UniRef50_P15925 Cluster: Folylpolyglutamate synthase; n=2;
Lactobacillus casei|Rep: Folylpolyglutamate synthase -
Lactobacillus casei
Length = 428
Score = 109 bits (263), Expect = 1e-22
Identities = 61/158 (38%), Positives = 86/158 (54%), Gaps = 2/158 (1%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+HV GT GKGS + +L G G Y+SP ++ ER+ ++ I +
Sbjct: 42 IHVTGTNGKGSAANAIAHVLEASGLTVGLYTSPFIMRFNERIMIDHEPIPDAALVNAVAF 101
Query: 660 VHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V LE Q+ + D F F+T + Y F + +VDVA++EVGIGG D TN++ PV
Sbjct: 102 VRAALERLQQQQADFNVTEFEFITALGYWYFRQRQVDVAVIEVGIGGDTDSTNVI--TPV 159
Query: 837 VGI-TALGLDHTSILGNTIQEIAASKAGIMKRGCEAYT 947
V + T + LDH +LG+TI IA KAGI+KRG T
Sbjct: 160 VSVLTEVALDHQKLLGHTITAIAKHKAGIIKRGIPVVT 197
>UniRef50_Q15VG0 Cluster: FolC bifunctional protein; n=1;
Pseudoalteromonas atlantica T6c|Rep: FolC bifunctional
protein - Pseudoalteromonas atlantica (strain T6c /
BAA-1087)
Length = 426
Score = 109 bits (262), Expect = 1e-22
Identities = 67/173 (38%), Positives = 95/173 (54%), Gaps = 1/173 (0%)
Frame = +3
Query: 411 LEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVA 590
LE + + ++ SK +VV VAGT GKG+T A E G R G YSSPHL+
Sbjct: 36 LERVNKVFEQLNISFSKQ---TVVTVAGTNGKGTTCAFLEQACLAAGKRVGVYSSPHLIQ 92
Query: 591 VRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVD 767
ERVR+NG SE + F V ++ GD+P YF F T+ + VD
Sbjct: 93 YTERVRINGIDGSEQAHCRAFQAV-------ERARGDIPLTYFEFGTLAGLKLVHDANVD 145
Query: 768 VAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
+A++EVG+GG +D N++ + IT++ LDH LG+T + +AA KAGIM+
Sbjct: 146 IALLEVGLGGRLDAVNVV-SPDIAVITSIDLDHQDFLGDTKELVAAEKAGIMR 197
>UniRef50_A7C245 Cluster: Folylpolyglutamate synthase/dihydrofolate
synthase; n=1; Beggiatoa sp. PS|Rep: Folylpolyglutamate
synthase/dihydrofolate synthase - Beggiatoa sp. PS
Length = 441
Score = 109 bits (261), Expect = 2e-22
Identities = 70/200 (35%), Positives = 102/200 (51%), Gaps = 1/200 (0%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
++ VAGT GKGS+ + +SIL G+ G + SPHL+ ER+ + G S+ F
Sbjct: 44 IITVAGTNGKGSSIILLDSILSTAGYHVGRFMSPHLLRYNERICVGGVEASDVQICHTF- 102
Query: 657 DVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
E +K G++ YF F T+ A IF +VD+A++EVG+GG +D NI
Sbjct: 103 ------ELIEKVRGEISLTYFEFSTLAAMLIFQHNQVDIAVLEVGLGGRLDAVNIF-DAD 155
Query: 834 VVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
+ +TA+ +DHT LGN + I KAGI + C A V LI YA+ LK PL
Sbjct: 156 ITLVTAIDIDHTDWLGNDRESIGFEKAGIFRAHCPA--VCSDTNPPQSLINYAEHLKTPL 213
Query: 1014 TXVPXYXLLLXRKIXKKPXY 1073
+ + +K K P +
Sbjct: 214 YYL-NHDFSYFKKADKNPSW 232
>UniRef50_Q9RXH3 Cluster: Folyl-polyglutamate synthetase; n=2;
Deinococcus|Rep: Folyl-polyglutamate synthetase -
Deinococcus radiodurans
Length = 416
Score = 108 bits (260), Expect = 2e-22
Identities = 66/182 (36%), Positives = 93/182 (51%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
+ + V GT GKGST AM E+ L G R G ++SPHL A ER+R+ G + A+
Sbjct: 60 KFQTIRVVGTNGKGSTCAMLEAGLLAAGVRAGRFTSPHLHAYEERIRVGGENLDPARTAQ 119
Query: 648 YFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
+ D K +F +A F + VD A++E G+GG+ D T L
Sbjct: 120 FI--------DWAKQNAPGEAFFDLTLALACQAFAEAGVDWAVMEAGVGGVSDATQALGN 171
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKC 1007
V V +T LDHT+ LG TI++IA+ KAG+ + G T EA+DV+ + A L
Sbjct: 172 VRAVALTNADLDHTATLGPTIRDIASDKAGVAQAGVPLLTT-ATGEALDVVREVAAELGA 230
Query: 1008 PL 1013
PL
Sbjct: 231 PL 232
>UniRef50_Q9CN13 Cluster: FolC; n=7; Pasteurellaceae|Rep: FolC -
Pasteurella multocida
Length = 442
Score = 108 bits (260), Expect = 2e-22
Identities = 63/180 (35%), Positives = 100/180 (55%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ V GT GKG+T + E++L G+R G YSSPHL+ ERVR+ + + ++ F
Sbjct: 52 VITVGGTNGKGTTCRLLETVLLKAGYRVGVYSSPHLLRYNERVRIQDQELPDEAHTASFA 111
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
+ Q ++ YF F T+ A ++F + +DV I+EVG+GG +D TNI+ V
Sbjct: 112 FIEQHKRESL-------TYFEFSTLSALHLFKQANLDVVILEVGLGGRLDATNIVDS-DV 163
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLT 1016
IT++ +DH LG ++I KAGI R + + +PN L+++A SL C ++
Sbjct: 164 AVITSIDIDHVDFLGADREQIGFEKAGIF-RAHKPAIIGEPN-IPQRLLEHAKSLGCQIS 221
>UniRef50_Q6KZL1 Cluster: Folylpolyglutamate synthase/dihydrofolate
synthase; n=3; Thermoplasmatales|Rep: Folylpolyglutamate
synthase/dihydrofolate synthase - Picrophilus torridus
Length = 435
Score = 108 bits (260), Expect = 2e-22
Identities = 58/157 (36%), Positives = 88/157 (56%), Gaps = 1/157 (0%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
D+ +H+AGT GKGS S+ +ILR + TG Y+SPHL+ ER+ N +IS+D
Sbjct: 35 DKYKKIHIAGTNGKGSISSYIYNILRQR-YNTGLYTSPHLIKFNERIIFNKEMISDDYII 93
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
+ + ++ K + + P +F TVMA+ F D A +EVG+GG +D TNI+
Sbjct: 94 NFISENRDYIDKLSKIKMN-PTFFETTTVMAFKYFYDMHADYAAIEVGLGGRLDSTNII- 151
Query: 825 KVPVVGITA-LGLDHTSILGNTIQEIAASKAGIMKRG 932
+P + I +G +H LG ++ IA K GI+K G
Sbjct: 152 -IPEISIIGQIGYEHYQKLGCSLTSIAYEKGGIIKPG 187
>UniRef50_Q3B220 Cluster: Folylpolyglutamate synthetase; n=7;
Chlorobium/Pelodictyon group|Rep: Folylpolyglutamate
synthetase - Pelodictyon luteolum (strain DSM 273)
(Chlorobium luteolum (strain DSM273))
Length = 443
Score = 108 bits (259), Expect = 3e-22
Identities = 62/162 (38%), Positives = 91/162 (56%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
VVHVAGT GKG+ ++ S+ G +T Y+SPHLV ER+R++GR I ED A+Y
Sbjct: 52 VVHVAGTNGKGTAASAMASMFTAAGKKTALYTSPHLVDFTERIRIDGRRIPEDAAARYAT 111
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
+ + Q +F T +A+ F V+V+++E G+GG +D TN++
Sbjct: 112 LLKPAALEHQS------TFFEVTTAIAFAWFADCGVEVSVLETGMGGRLDATNVVESDYA 165
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPN 962
V +T +GLDHT LG+TI IA KA I+K +T P+
Sbjct: 166 V-LTRIGLDHTEWLGSTISAIAGEKAAIIKPSSRVFTSINPD 206
>UniRef50_UPI00005100A3 Cluster: COG0285: Folylpolyglutamate
synthase; n=1; Brevibacterium linens BL2|Rep: COG0285:
Folylpolyglutamate synthase - Brevibacterium linens BL2
Length = 462
Score = 107 bits (257), Expect = 5e-22
Identities = 60/165 (36%), Positives = 93/165 (56%), Gaps = 4/165 (2%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ V GT GK ST+ M ++I+ H R G ++SPHL +V ER+ ++G + + F +
Sbjct: 53 VITVTGTNGKTSTARMIDAIVTAHDLRVGRFTSPHLHSVTERISVDGGPVPAETFVRIHD 112
Query: 657 DVHQRLE--DTQKF-EG-DMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
++ L+ D + EG +F LT++A+ +F VDV + EVG+GG D TN+
Sbjct: 113 EIAPVLDLVDAELLAEGRGRLTFFEALTILAFAVFADAPVDVVVTEVGMGGEWDSTNV-A 171
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQP 959
V T +GLDH + LG+T+ EIA +KAGI+ R + P
Sbjct: 172 DAEVCVFTKIGLDHQAFLGDTLTEIATTKAGILNRSLDPSPAPNP 216
>UniRef50_Q62AJ8 Cluster: FolC bifunctional protein; n=25;
Betaproteobacteria|Rep: FolC bifunctional protein -
Burkholderia mallei (Pseudomonas mallei)
Length = 437
Score = 107 bits (257), Expect = 5e-22
Identities = 56/152 (36%), Positives = 87/152 (57%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ V GT GKGST A E+IL G++ G ++SPHL+ ER RL+GR++ ++ +F
Sbjct: 44 VITVGGTNGKGSTCAFIETILVRAGYKVGCHTSPHLLRFNERARLDGRIVDDEELLPHFE 103
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V T E YF F T+ ++F +D I+EVG+GG +D N++
Sbjct: 104 AV--EAARTSLPEAVSLTYFEFTTLAIMHLFASRGLDAVILEVGLGGRLDAVNVIDADCA 161
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
+ +T++ +DH LG+T ++IA KAGI + G
Sbjct: 162 I-VTSIDVDHIEYLGDTREKIAFEKAGIFRPG 192
>UniRef50_Q3JCB5 Cluster: Folylpolyglutamate synthetase; n=1;
Nitrosococcus oceani ATCC 19707|Rep: Folylpolyglutamate
synthetase - Nitrosococcus oceani (strain ATCC 19707 /
NCIMB 11848)
Length = 432
Score = 107 bits (257), Expect = 5e-22
Identities = 58/150 (38%), Positives = 89/150 (59%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
+V +AGT GKGST A+ E+IL G+R G Y+SPHL+ ER+++ G +S+D+ + F
Sbjct: 45 IVTIAGTNGKGSTVALLEAILLAAGYRVGSYTSPHLLRYNERIKIQGEAVSDDIICQSFA 104
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
+ D + E + YF F T+ A +IF + +D+A++EVG+GG +D N L V
Sbjct: 105 RI-----DAARHEISL-TYFEFGTLAAIDIFHQAGLDIALLEVGLGGRLDAVNAL-DADV 157
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMK 926
IT + +DH + LG + I KAGI +
Sbjct: 158 AVITTVDIDHINFLGPDRESIGFEKAGIFR 187
>UniRef50_Q0ATK3 Cluster: FolC bifunctional protein; n=1; Maricaulis
maris MCS10|Rep: FolC bifunctional protein - Maricaulis
maris (strain MCS10)
Length = 397
Score = 107 bits (257), Expect = 5e-22
Identities = 64/177 (36%), Positives = 92/177 (51%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+HVAGT GKGST A + R G R Y+SPHLV ER+ L+ R + + + F
Sbjct: 5 IHVAGTNGKGSTCAYLAEMARAKGERVHIYTSPHLVNFNERILLDSRPVDDRTLIEAF-- 62
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
R E F G+ +F T A+ +F + D I+EVG+GG +D TN++ K +
Sbjct: 63 --ARCE-AANF-GEPITFFEITTAAAFLLFSEHPADRLILEVGMGGRLDATNVIAKPALT 118
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCP 1010
IT + LDH LG+ + +IA +KAGI K G A Q + A ++ A + P
Sbjct: 119 VITPVSLDHQEFLGDQLADIARTKAGICKFGVPAVIANQCDVAEAAILDEATKIGAP 175
>UniRef50_A1W9F5 Cluster: FolC bifunctional protein; n=33;
Burkholderiales|Rep: FolC bifunctional protein -
Acidovorax sp. (strain JS42)
Length = 441
Score = 107 bits (257), Expect = 5e-22
Identities = 62/152 (40%), Positives = 82/152 (53%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ VAGT GKGST AM E++ G+RTG Y+SPHLV ER R+ G ++ F
Sbjct: 45 VITVAGTNGKGSTCAMLEAVALQAGYRTGVYTSPHLVHFEERCRIRGEIVDAASLVASFE 104
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V + TQ YF F T+ +DVAI+EVG+GG +D TNI+
Sbjct: 105 AVER--ARTQNGNEVTLTYFEFTTLAILRHMSLSLLDVAILEVGLGGRLDATNIIDADCA 162
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
V IT++ +DH LG + I KAGIM+ G
Sbjct: 163 V-ITSVDIDHVEFLGPDRETIGREKAGIMRTG 193
>UniRef50_Q1GU94 Cluster: FolC bifunctional protein; n=5;
Sphingomonadales|Rep: FolC bifunctional protein -
Sphingopyxis alaskensis (Sphingomonas alaskensis)
Length = 443
Score = 107 bits (256), Expect = 7e-22
Identities = 74/215 (34%), Positives = 96/215 (44%), Gaps = 8/215 (3%)
Frame = +3
Query: 393 GQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYS 572
G+ LE + R G +L V HVAGT GKGST A + + G YS
Sbjct: 25 GRDILGLERITELCHRLGDPQHRLPP--VFHVAGTNGKGSTCAFLRAAIEAQGLTAHVYS 82
Query: 573 SPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFL 752
SPHLV ER+RL G +I + + A +V ED Q +F T A+ F
Sbjct: 83 SPHLVRFNERIRLAGALIDDALLAALLAEVLDVAEDLQ------ASFFEVTTASAFLAFA 136
Query: 753 KEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSIL--------GNTIQEIAAS 908
+ D IVEVG+GG +D TNI+ V GI +LG+DH + L IA
Sbjct: 137 RTPADACIVEVGLGGRLDATNIIAAPTVCGIASLGIDHEAFLLAPEADVPAPPHDRIAFE 196
Query: 909 KAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
K GI K G T P V+ A ++ PL
Sbjct: 197 KVGIAKPGAPLVTQAYPASMRAVIAARAAAVGAPL 231
>UniRef50_Q0USC9 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 643
Score = 107 bits (256), Expect = 7e-22
Identities = 65/176 (36%), Positives = 93/176 (52%), Gaps = 2/176 (1%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+HVAGT GKGS SIL+ R G ++SPHLV + +++NG +S+ F
Sbjct: 23 IHVAGTNGKGSICHYAASILKRRTIRVGTFNSPHLVDRWDCIKINGEPVSKTSFTT---- 78
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
+ ++ E F LT A F K KV V IVEVG+GG +D TNI+ +
Sbjct: 79 IEKQFLTRNLTEEINASPFEILTATALACFNKAKVQVGIVEVGMGGRLDATNIINNQCIS 138
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNE--AMDVLIQYADSL 1001
I+ + DH + LG+T++EIA KAGI++ YTV NE V+ +YA +
Sbjct: 139 VISKIARDHEAFLGSTLEEIAKHKAGILRPNV-PYTVNPENEFHVQHVIDEYAKEI 193
>UniRef50_Q0AGX2 Cluster: FolC bifunctional protein; n=1;
Nitrosomonas eutropha C91|Rep: FolC bifunctional protein
- Nitrosomonas eutropha (strain C71)
Length = 428
Score = 106 bits (255), Expect = 1e-21
Identities = 58/155 (37%), Positives = 89/155 (57%)
Frame = +3
Query: 462 LDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMF 641
+ + V+ VAGT GKGS + ESIL +R G Y+SPHL+ ER+R++ R I++++
Sbjct: 41 MPKFPVITVAGTNGKGSVCTILESILGRASYRVGCYTSPHLLHYGERIRIDQRAITDEVL 100
Query: 642 AKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNIL 821
F ++ E Q YF F T+ A IF++ +VDVAI+EVG+GG +D N+
Sbjct: 101 CGVFAEIESVRESVQV----TLTYFEFGTLAAMLIFVRAQVDVAILEVGLGGRLDAVNVF 156
Query: 822 RKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
+ +T++ LDH LG+T + I K GI +
Sbjct: 157 DTDCAI-LTSIDLDHMDYLGSTREAIGQEKIGIFR 190
>UniRef50_Q5V5Y3 Cluster: Dihydropteroate synthase; n=1; Haloarcula
marismortui|Rep: Dihydropteroate synthase - Haloarcula
marismortui (Halobacterium marismortui)
Length = 799
Score = 106 bits (255), Expect = 1e-21
Identities = 60/174 (34%), Positives = 94/174 (54%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
V +AG+ GKGST+ M ES+LR G G ++SP L RE++ +NG + + ++
Sbjct: 42 VQIAGSNGKGSTARMTESVLRAAGLDVGLFTSPGLNGFREQITVNGGRVPKARVTEFVEQ 101
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
+ + E D P +F LT +A F E VDVA++EVGIGG D T+ + V
Sbjct: 102 IEPCINQLAA-EDDKPTHFEVLTALALYHFDVEDVDVAVLEVGIGGRYDATSAVDPV-AS 159
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSL 1001
+T++ L+HT +LG+TI+EIA K + T A+D + + D++
Sbjct: 160 AVTSISLEHTDLLGDTIEEIARDKGQVAPSDAPLVT-GTAGAALDAIQEITDTI 212
>UniRef50_Q97AP2 Cluster: Folylpolyglutamate synthase; n=2;
Thermoplasma volcanium|Rep: Folylpolyglutamate synthase
- Thermoplasma volcanium
Length = 407
Score = 106 bits (254), Expect = 1e-21
Identities = 58/152 (38%), Positives = 86/152 (56%), Gaps = 1/152 (0%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+H+ G+ GKGSTSA SILR F G Y+SPHL ER+ ++ + ++ +
Sbjct: 19 IHITGSNGKGSTSAFIYSILRQK-FSVGVYTSPHLERFNERIIVDNEEVPDEYIDGFIEK 77
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
+ ++ K + P +F T+MA+ F KVD A VEVG+GG +D TNI+ +P V
Sbjct: 78 YRPKFDELSKVNRN-PTFFEVTTMMAFQYFKDRKVDYASVEVGLGGRLDATNII--MPEV 134
Query: 840 GITA-LGLDHTSILGNTIQEIAASKAGIMKRG 932
+ A +G +H LG ++ IA KAGI+K G
Sbjct: 135 SVIAQVGYEHADKLGCSLTSIAYEKAGIIKEG 166
>UniRef50_Q2ZYL0 Cluster: Folylpolyglutamate synthetase; n=5;
Streptococcus suis|Rep: Folylpolyglutamate synthetase -
Streptococcus suis 89/1591
Length = 418
Score = 105 bits (253), Expect = 2e-21
Identities = 66/205 (32%), Positives = 108/205 (52%), Gaps = 7/205 (3%)
Frame = +3
Query: 417 DMENYLSRTGVTMSKLD----ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHL 584
D+E+ ++R + +LD ++S +H GT GKGST +SIL+ + G ++SP +
Sbjct: 17 DLEHGVARVNWILERLDNPQLQVSTIHFVGTNGKGSTLNALQSILQSSDYTVGRFTSPSI 76
Query: 585 VAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEG-DMPKYFAFLTVMAYNIFLK-E 758
+ RE++ +ISE+ F + D+ +ED + G D F + V + F +
Sbjct: 77 IDFREQIVFEQEMISEEDFVRIVTDLQPLIEDLDQTAGLDAISEFEIVVVAMFVYFAHYQ 136
Query: 759 KVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK-RGC 935
+ D+ +VE G+GGL D TN+L + VV ++GLDH + LG T IA K +++ R
Sbjct: 137 RPDILLVEAGMGGLQDATNVLAPLAVV-CPSIGLDHQAFLGETHAAIARHKVAVLRERVP 195
Query: 936 EAYTVQQPNEAMDVLIQYADSLKCP 1010
Y QP E + V +A L+ P
Sbjct: 196 LLYATDQP-EVVAVFEDHASQLQSP 219
>UniRef50_A4E6Z7 Cluster: Putative uncharacterized protein; n=1;
Collinsella aerofaciens ATCC 25986|Rep: Putative
uncharacterized protein - Collinsella aerofaciens ATCC
25986
Length = 459
Score = 105 bits (253), Expect = 2e-21
Identities = 61/157 (38%), Positives = 91/157 (57%), Gaps = 6/157 (3%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH- 656
+ VAGT GK ST+ ++L G +T Y+SP LV ER+ ++GRV+S++ FA+
Sbjct: 72 IQVAGTNGKTSTTRFSAAVLCGEGLKTALYTSPQLVRYPERMEVDGRVVSDEAFARGVSA 131
Query: 657 --DVHQRLEDTQKFEGDMP---KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNIL 821
+ R+ + G+ F LT A +F + +VDVA++EVG+GG D T+
Sbjct: 132 AVEAGHRVNARRIAAGERAYTITPFDLLTAAALVVFAEARVDVAVLEVGMGGRWDATSAT 191
Query: 822 RKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
V V IT +GLDHT ILG+T++ IA KA ++K G
Sbjct: 192 DPV-AVAITGIGLDHTRILGDTLEAIAGEKAAVIKPG 227
>UniRef50_Q12676 Cluster: Folylpolyglutamate synthase; n=5;
Saccharomycetales|Rep: Folylpolyglutamate synthase -
Saccharomyces cerevisiae (Baker's yeast)
Length = 427
Score = 105 bits (253), Expect = 2e-21
Identities = 57/170 (33%), Positives = 89/170 (52%), Gaps = 2/170 (1%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
+ L V+H+AGT GKGS S+L+ ++ G +++PHLV V + + +N + I
Sbjct: 22 NSLRVLHIAGTNGKGSVCTYLSSVLQQKSYQIGKFTTPHLVHVTDSITINNKPIP----L 77
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNIL- 821
+ + ++ +LE K F LT A+ F + ++EVG+GG +D TN++
Sbjct: 78 ERYQNIRLQLEALNKSHSLKCTEFELLTCTAFKYFYDVQCQWCVIEVGLGGRLDATNVIP 137
Query: 822 -RKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEA 968
GIT + LDH S LGNT+ EI+ KAGI+ G + NEA
Sbjct: 138 GANKACCGITKISLDHESFLGNTLSEISKEKAGIITEGVPFTVIDGTNEA 187
>UniRef50_A6FEP3 Cluster: Dihydrofolate synthase /
folylpolyglutamate synthase; n=1; Moritella sp.
PE36|Rep: Dihydrofolate synthase / folylpolyglutamate
synthase - Moritella sp. PE36
Length = 441
Score = 105 bits (252), Expect = 2e-21
Identities = 62/155 (40%), Positives = 84/155 (54%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ VAGT GKGST A E IL GF G SSPH+ RERVR+NG++++ A F
Sbjct: 49 VITVAGTNGKGSTCAFLERILLDAGFNVGVTSSPHIQDYRERVRVNGKMLTAQAHADSFA 108
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
+ DT YF F T+ + +F +DV I+EVG+GG +D +NI+ V
Sbjct: 109 FIEAGRGDTTL------TYFEFTTLSSLKLFQDAALDVVILEVGLGGRLDASNIV-SADV 161
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEA 941
+T + +DH LG IA KAGI + G +A
Sbjct: 162 AVVTTIDIDHADWLGTDKAVIAREKAGIFRAGKKA 196
>UniRef50_A4BRV9 Cluster: Folylpolyglutamate synthase/dihydrofolate
synthase; n=1; Nitrococcus mobilis Nb-231|Rep:
Folylpolyglutamate synthase/dihydrofolate synthase -
Nitrococcus mobilis Nb-231
Length = 426
Score = 105 bits (252), Expect = 2e-21
Identities = 61/152 (40%), Positives = 85/152 (55%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ V GT GKGST A E++LR G+ G YSSPH+ ER+R++GR +++ F
Sbjct: 44 VITVGGTNGKGSTVAYLEAMLRALGYHPGVYSSPHVQRYNERIRIDGREATDEAIVAAFE 103
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V + DT YF F T+ A ++F + DV ++EVG+GG +D NIL V
Sbjct: 104 AVDEARSDTPL------TYFEFGTLAALHLFQLTQCDVWLLEVGMGGRLDAVNIL-AADV 156
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
+T + LDHT LG+ I KAGIM+ G
Sbjct: 157 AVLTNVELDHTDWLGHDRDSIGREKAGIMRPG 188
>UniRef50_Q4UH02 Cluster: Dihydrofolate synthase/folylpolyglutamate
synthase, putative; n=2; Theileria|Rep: Dihydrofolate
synthase/folylpolyglutamate synthase, putative -
Theileria annulata
Length = 411
Score = 105 bits (252), Expect = 2e-21
Identities = 64/190 (33%), Positives = 101/190 (53%), Gaps = 2/190 (1%)
Frame = +3
Query: 423 ENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRER 602
+N+L + K D+ +++HV+GT GK S + L G + G ++SPH+ ER
Sbjct: 24 DNFLKCINLLGIKTDQFNIIHVSGTNGKSSVAFKVSKCLISLGLKVGLFTSPHIFEYTER 83
Query: 603 VRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNI--FLKEKVDVAI 776
VR+ I + F + + + GDMP +F F T++ ++ F ++KV+ +
Sbjct: 84 VRVQCVQIPKRDFVRITDYIFSVV-------GDMPIHF-FSTILLISLVYFTEKKVEWVV 135
Query: 777 VEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQ 956
+E GIGGL+D TN V I+++G DH ILG T+ EIA KAG +KRG + V
Sbjct: 136 LESGIGGLLDPTNFAPNTKAVVISSIGYDHMEILGKTLDEIALQKAGTIKRG--SVVVLG 193
Query: 957 PNEAMDVLIQ 986
PN D + +
Sbjct: 194 PNCHKDEIFE 203
>UniRef50_Q8K9X3 Cluster: Bifunctional protein folC [Includes:
Folylpolyglutamate synthase (EC 6.3.2.17)
(Folylpoly-gamma-glutamate synthetase) (FPGS)
(Tetrahydrofolate synthase)
(Tetrahydrofolylpolyglutamate synthase); Dihydrofolate
synthase (EC 6.3.2.12)]; n=1; Buchnera aphidicola
(Schizaphis graminum)|Rep: Bifunctional protein folC
[Includes: Folylpolyglutamate synthase (EC 6.3.2.17)
(Folylpoly-gamma-glutamate synthetase) (FPGS)
(Tetrahydrofolate synthase)
(Tetrahydrofolylpolyglutamate synthase); Dihydrofolate
synthase (EC 6.3.2.12)] - Buchnera aphidicola subsp.
Schizaphis graminum
Length = 418
Score = 105 bits (252), Expect = 2e-21
Identities = 59/149 (39%), Positives = 87/149 (58%)
Frame = +3
Query: 486 VAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVH 665
V GT GKG+T AM E +L G++ G Y+SPHL+ ER+++NG +SE H
Sbjct: 48 VGGTNGKGTTCAMLEKLLLDSGYQVGLYTSPHLINYSERIKVNGLYLSEK-----DHIFS 102
Query: 666 QRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGI 845
+ D +K + YF F+T+ A +F + +D+ I+EVG+GG +D TNI+ V I
Sbjct: 103 FLIIDAEKGNVSL-TYFEFITLSALFLFSQYSLDIIILEVGLGGRLDATNIIDSDLSV-I 160
Query: 846 TALGLDHTSILGNTIQEIAASKAGIMKRG 932
T +G+DHTS LG I K+GI ++G
Sbjct: 161 TNIGIDHTSCLGTDRISIGREKSGIFRKG 189
>UniRef50_A6SPC7 Cluster: Putative uncharacterized protein; n=2;
Sclerotiniaceae|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 510
Score = 105 bits (251), Expect = 3e-21
Identities = 70/210 (33%), Positives = 106/210 (50%), Gaps = 7/210 (3%)
Frame = +3
Query: 414 EDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTG------FYSS 575
+ M +L G T D V+H+AGTKGK ST +S L + RTG Y++
Sbjct: 66 DGMTEWLDALGYTHKDFD---VIHIAGTKGKASTCMFVKSFLSSYASRTGVVKKIGLYTN 122
Query: 576 PHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKF-EGDMPKYFAFLTVMAYNIFL 752
P+ +RE +++N + +SED FA+YF V + L + KF E MP + ++A F+
Sbjct: 123 PYSPNIREPIKINAKPVSEDKFARYFFQVWEIL--SGKFAETMMPDFMQLRLLVAIYTFM 180
Query: 753 KEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
E VDV I+E GG D TN ++ V VGI + ++ G + +++A GIMK
Sbjct: 181 GEDVDVVIMETHCGGETDATNFVKPV-AVGIAQIHAEYVESGGPSSEDLAWHAGGIMKTE 239
Query: 933 CEAYTVQQPNEAMDVLIQYADSLKCPLTXV 1022
A+++ Q E VL A+ L V
Sbjct: 240 APAFSIPQGPEIEKVLETRANEKSAALNFV 269
>UniRef50_Q8D2P3 Cluster: FolC protein; n=1; Wigglesworthia
glossinidia endosymbiont of Glossina brevipalpis|Rep:
FolC protein - Wigglesworthia glossinidia brevipalpis
Length = 428
Score = 104 bits (250), Expect = 4e-21
Identities = 54/147 (36%), Positives = 85/147 (57%)
Frame = +3
Query: 486 VAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVH 665
V GT GKGST E + + + G YSSPHL+ ER+RL+G +S++ + ++
Sbjct: 54 VGGTNGKGSTCRFLELMFIYSNIKVGVYSSPHLINYNERIRLHGNEVSDEECINAMNFIN 113
Query: 666 QRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGI 845
+ ++ T YF F T++A IF +K+DV I+EVG+GG +D TN++ + + +
Sbjct: 114 KIIKKTS------ISYFEFSTLVALLIFKSKKLDVVILEVGLGGRLDATNVV-DIDISVV 166
Query: 846 TALGLDHTSILGNTIQEIAASKAGIMK 926
T + +DHT LG EIA K+GI +
Sbjct: 167 TNVSIDHTEFLGKNCSEIAKEKSGIFR 193
>UniRef50_Q0A999 Cluster: FolC bifunctional protein; n=1;
Alkalilimnicola ehrlichei MLHE-1|Rep: FolC bifunctional
protein - Alkalilimnicola ehrlichei (strain MLHE-1)
Length = 437
Score = 104 bits (250), Expect = 4e-21
Identities = 66/180 (36%), Positives = 99/180 (55%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ VAGT GKGS A E++L G+RT Y+SPHL+ ER+RL G +S++ F
Sbjct: 57 VITVAGTNGKGSCIAYLEAMLGAAGYRTAAYTSPHLLRYNERIRLAGVPVSDEAITAAFS 116
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V Q + T YF + T+ A ++F + + +V ++EVG+GG +D N +
Sbjct: 117 RVEQARQGTPL------TYFEYGTLAALSLFSEAEAEVWLLEVGMGGRLDAVNAVDPDLS 170
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPLT 1016
+ IT++GLDHT LG + I A KAGIM+ G Q + D + A +L+ P+T
Sbjct: 171 I-ITSIGLDHTEWLGADRERIGAEKAGIMRPGRPVCLGQA--DLPDSVSDRARTLRAPVT 227
>UniRef50_A0W7P3 Cluster: FolC bifunctional protein precursor; n=2;
Desulfuromonadales|Rep: FolC bifunctional protein
precursor - Geobacter lovleyi SZ
Length = 428
Score = 104 bits (250), Expect = 4e-21
Identities = 59/172 (34%), Positives = 90/172 (52%)
Frame = +3
Query: 474 SVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYF 653
+ +HV GT GKGST+A +I+ G+ TG ++SPHLV+ ER R+NG +
Sbjct: 40 AAIHVVGTNGKGSTAAFLAAIIEQAGYCTGLFTSPHLVSYTERFRVNGVDCPPEQLEALI 99
Query: 654 HDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
D+ LE G +F T +A + F + KV +A++E G+GG D T + +
Sbjct: 100 PDL---LEQA----GPDDTFFELTTALACHWFARNKVQLAVLEAGMGGRSDATAAVAGIA 152
Query: 834 VVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQY 989
+ I+ + LDH LGN +Q IAA K I + G + QP + V+ +Y
Sbjct: 153 TI-ISPIALDHCQWLGNDLQSIAAEKVAIARPGSPVISAVQPPDVQAVIEEY 203
>UniRef50_Q6CHD4 Cluster: Similar to sp|Q12676 Saccharomyces
cerevisiae YMR113w FOL3 dihydrofolate synthetase; n=1;
Yarrowia lipolytica|Rep: Similar to sp|Q12676
Saccharomyces cerevisiae YMR113w FOL3 dihydrofolate
synthetase - Yarrowia lipolytica (Candida lipolytica)
Length = 406
Score = 104 bits (250), Expect = 4e-21
Identities = 58/158 (36%), Positives = 89/158 (56%), Gaps = 2/158 (1%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
+ VHVAGT GKGS A S+L +TG ++SPHL V + + ++G+ + + F
Sbjct: 21 NRFKAVHVAGTNGKGSICAYISSVLTVSHIKTGRFTSPHLAYVWDCITIDGKAVEKSDFL 80
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNIL- 821
+ + + K E P F LT A+ +F++ V++A+VEVG+GG +D TN+L
Sbjct: 81 SAKAKICE-VAKNGKLE---PTEFEMLTATAFELFMEHSVEIAVVEVGLGGRLDATNVLC 136
Query: 822 -RKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
V V I+ +G+DH LG+ ++ IA KAGI K G
Sbjct: 137 PENVLVSVISRVGMDHEGFLGDNLRAIAKEKAGIAKIG 174
>UniRef50_A5DAQ6 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 412
Score = 103 bits (248), Expect = 7e-21
Identities = 69/186 (37%), Positives = 95/186 (51%), Gaps = 9/186 (4%)
Frame = +3
Query: 483 HVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDV 662
HVAGT GKGST A S+L R G ++SPH+V + V +N + F + V
Sbjct: 28 HVAGTNGKGSTVAYLSSVLTSSKVRNGRFTSPHMVYYNDCVCINNEIYPMPKFEQVRALV 87
Query: 663 HQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK----- 827
Q D K + F LT A+ IF E+V++A++EVG+GG +D TN+L
Sbjct: 88 RQ-TNDELKLQ---CTEFELLTATAFKIFELEQVEIALIEVGLGGRLDATNVLEANTVLL 143
Query: 828 --VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLI--QYAD 995
V V IT + DH LGNT+++IA KAGI+K + NE + +L A
Sbjct: 144 PGVVVTAITKIAFDHEGFLGNTLEKIANEKAGILKENIPC-VIDGTNEELVLLTVQSKAA 202
Query: 996 SLKCPL 1013
SL C L
Sbjct: 203 SLNCKL 208
>UniRef50_Q0BWJ9 Cluster: Putative folylpolyglutamate synthase; n=1;
Hyphomonas neptunium ATCC 15444|Rep: Putative
folylpolyglutamate synthase - Hyphomonas neptunium
(strain ATCC 15444)
Length = 417
Score = 103 bits (246), Expect = 1e-20
Identities = 67/202 (33%), Positives = 98/202 (48%)
Frame = +3
Query: 408 NLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLV 587
+L +E+ L G +L V+HVAGT GKGST A ++ G + ++SPHLV
Sbjct: 26 SLGRIEHALDALGRPQDRLPP--VIHVAGTNGKGSTCAFMRAMAEAAGLKVHVFTSPHLV 83
Query: 588 AVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVD 767
ER+RL G+++ + + + + G +F T A F + D
Sbjct: 84 RFNERIRLAGKLVEDAALIGWLDRTFEAIG------GGQITHFEATTAAALLAFSEVPAD 137
Query: 768 VAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYT 947
V I+EVG+GG D TN++ + IT + DH LG + IAA KAGI+K G A T
Sbjct: 138 VLILEVGLGGKYDATNVIGAPALSVITPVDYDHAQFLGTDLAGIAAEKAGIIKAGRPALT 197
Query: 948 VQQPNEAMDVLIQYADSLKCPL 1013
Q + A V+ A + PL
Sbjct: 198 SIQQDVADAVITARAAEVGAPL 219
>UniRef50_A5IBI5 Cluster: FolC bifunctional protein; n=4; Legionella
pneumophila|Rep: FolC bifunctional protein - Legionella
pneumophila (strain Corby)
Length = 428
Score = 103 bits (246), Expect = 1e-20
Identities = 67/203 (33%), Positives = 103/203 (50%), Gaps = 6/203 (2%)
Frame = +3
Query: 408 NLEDMENYLSRTGVTMSKLD----ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSS 575
N ++++ L+R KL+ V+ VAGT GKGST E+I GFR G Y+S
Sbjct: 21 NTQEIQLGLTRVLTVAQKLNLQRPNCKVITVAGTNGKGSTVTALETIYHQSGFRVGTYTS 80
Query: 576 PHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLK 755
PHL+ ER+R+N I + K F + + T YF T+ A F +
Sbjct: 81 PHLLVFNERIRINLTPIQDKDLCKAFSVIEEARYPTNL------TYFEMATLAALWYFKQ 134
Query: 756 EKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGC 935
+D+ I+EVG+GG +D TNI+ + IT + DH + LG+T++ I KAGI+++
Sbjct: 135 HDLDLIILEVGLGGRLDATNIV-DTDLAIITTIDFDHQNFLGDTLELIGYEKAGILRKNK 193
Query: 936 E-AYT-VQQPNEAMDVLIQYADS 998
Y + P ++V +Q S
Sbjct: 194 PFIYADLSPPKSVVEVALQLGAS 216
>UniRef50_Q89AT2 Cluster: Bifunctional protein folC [Includes:
Folylpolyglutamate synthase (EC 6.3.2.17)
(Folylpoly-gamma-glutamate synthetase) (FPGS)
(Tetrahydrofolate synthase)
(Tetrahydrofolylpolyglutamate synthase); Dihydrofolate
synthase (EC 6.3.2.12)]; n=2; Buchnera aphidicola|Rep:
Bifunctional protein folC [Includes: Folylpolyglutamate
synthase (EC 6.3.2.17) (Folylpoly-gamma-glutamate
synthetase) (FPGS) (Tetrahydrofolate synthase)
(Tetrahydrofolylpolyglutamate synthase); Dihydrofolate
synthase (EC 6.3.2.12)] - Buchnera aphidicola subsp.
Baizongia pistaciae
Length = 426
Score = 103 bits (246), Expect = 1e-20
Identities = 65/178 (36%), Positives = 98/178 (55%), Gaps = 5/178 (2%)
Frame = +3
Query: 411 LEDMENYLSRTGVTMSKLDELS----VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSP 578
L++++ L+R KL L V V GT GKGST + E++L + G+R G Y+SP
Sbjct: 24 LDNIDPTLNRVFYVAKKLGVLKSKAFVFIVGGTNGKGSTCHVLENLLLNSGYRVGLYTSP 83
Query: 579 HLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGD-MPKYFAFLTVMAYNIFLK 755
HL+ ERVR+NG + F+DV + F+ D + F F+T+ A +F
Sbjct: 84 HLMRYTERVRINGFELEHLYHISAFNDV-------KYFQNDVLLTRFEFITLSALILFKS 136
Query: 756 EKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKR 929
+D+ I+EVG+GG +D TNIL V IT + +DH+ ILG I+ K+GI ++
Sbjct: 137 YNLDIIILEVGLGGRLDATNIL-SADVSVITNIDIDHSKILGVNRSSISVEKSGIFRK 193
>UniRef50_Q1N6P7 Cluster: Folylpolyglutamate synthetase; n=1;
Oceanobacter sp. RED65|Rep: Folylpolyglutamate
synthetase - Oceanobacter sp. RED65
Length = 422
Score = 102 bits (245), Expect = 2e-20
Identities = 57/176 (32%), Positives = 93/176 (52%), Gaps = 4/176 (2%)
Frame = +3
Query: 414 EDMENYLSRTGVTMSKLDELS----VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPH 581
+D++ L R +LD + VV VAGT GKG+T A C + R GF G ++SPH
Sbjct: 18 KDIDLGLDRVRAVAERLDLIKPAKYVVLVAGTNGKGTTVATCGELFRQSGFSVGVFTSPH 77
Query: 582 LVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEK 761
+ ERV +NG+ +S+ F + + D YF + A +F +
Sbjct: 78 ITKYNERVSINGKQVSDAQLIDSFEAIESKRGDISL------TYFEVSALSALYLFKQAN 131
Query: 762 VDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKR 929
V+ A++E+G+GG +D N++ V +T++GLDH LG+T+ +I KAG+ ++
Sbjct: 132 VEAAVLEIGLGGRLDAVNLV-DPDVSIVTSIGLDHQDWLGDTLDKIGYEKAGVYRQ 186
>UniRef50_A3JGB7 Cluster: Folylpolyglutamate synthetase; n=3;
Marinobacter|Rep: Folylpolyglutamate synthetase -
Marinobacter sp. ELB17
Length = 445
Score = 102 bits (245), Expect = 2e-20
Identities = 66/179 (36%), Positives = 93/179 (51%), Gaps = 4/179 (2%)
Frame = +3
Query: 417 DMENYLSRTGVTMSKL----DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHL 584
++E L R V + +L E ++ VAGT GKGST A E++L+ G RT Y+SPHL
Sbjct: 37 EIELGLDRVMVVLQRLFPGKPEARIITVAGTNGKGSTVAALEALLQEAGRRTAAYTSPHL 96
Query: 585 VAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKV 764
ERVRL G IS+ F V + + YF F T+ A+ + V
Sbjct: 97 QVYNERVRLLGEQISDAQMIYGFERVQEARAEVSL------SYFEFGTLAAFVAMSEADV 150
Query: 765 DVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEA 941
D I+EVG+GG +D N+L V T++ +DH S LGN + I KAG+++ G A
Sbjct: 151 DDWILEVGLGGRLDAVNVL-DADFVIFTSIDIDHASFLGNDRESIGFEKAGVLRPGIPA 208
>UniRef50_Q83D50 Cluster: FolC bifunctional protein; n=4; Coxiella
burnetii|Rep: FolC bifunctional protein - Coxiella
burnetii
Length = 416
Score = 102 bits (244), Expect = 2e-20
Identities = 57/151 (37%), Positives = 88/151 (58%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
VV VAGT GKGS ESI G++ Y+SPHL+ ER+RLNG ++++F + F
Sbjct: 39 VVTVAGTNGKGSVVKSLESIYLAAGYKVAAYTSPHLLQFNERLRLNGEPATDELFIEAF- 97
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
+ +ED + + +F F T+ + I K+ +D+ ++EVG+GG +D NI+ + V
Sbjct: 98 ---KFIEDNRNHQ--PLSFFEFTTLAIFYICKKQNLDILLLEVGLGGRLDAVNIV-EPDV 151
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKR 929
IT + +DHT LG + I KAGI++R
Sbjct: 152 AVITTIDIDHTDWLGEDRESIGREKAGIIRR 182
>UniRef50_A0ECV5 Cluster: Chromosome undetermined scaffold_9, whole
genome shotgun sequence; n=1; Paramecium tetraurelia|Rep:
Chromosome undetermined scaffold_9, whole genome shotgun
sequence - Paramecium tetraurelia
Length = 258
Score = 102 bits (244), Expect = 2e-20
Identities = 64/202 (31%), Positives = 103/202 (50%), Gaps = 1/202 (0%)
Frame = +3
Query: 420 MENYLSRTGVTMSKLDELSVVHVAGTKGKGS-TSAMCESILRHHGFRTGFYSSPHLVAVR 596
+ N L T + + +L +H+AGT GKGS T MC+ L G ++SPH+ + R
Sbjct: 24 LANMLKMTQLLGNPQKDLQFIHIAGTNGKGSVTLKMCK--LMQSIESCGCFTSPHISSFR 81
Query: 597 ERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAI 776
ER++++ ++ISE+ ++ +D L + E +F ++T +A F +
Sbjct: 82 ERIKVDNQMISEEYVQEHLNDFFN-LAERSNLE---LTFFEYVTCLALKYFNDMHLKYVS 137
Query: 777 VEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQ 956
E G+GG +D TNI+ + IT +G DH ILGNT+ IA KAGI+K+ C +
Sbjct: 138 WETGLGGRMDSTNIITSPLISIITTIGFDHMHILGNTLDLIAKEKAGIIKQNCPV-VIGP 196
Query: 957 PNEAMDVLIQYADSLKCPLTXV 1022
+ ++ I A LT V
Sbjct: 197 KCQPYEIFINEATQKNADLTIV 218
>UniRef50_A6REJ0 Cluster: Putative uncharacterized protein; n=1;
Ajellomyces capsulatus NAm1|Rep: Putative uncharacterized
protein - Ajellomyces capsulatus NAm1
Length = 670
Score = 102 bits (244), Expect = 2e-20
Identities = 60/154 (38%), Positives = 89/154 (57%), Gaps = 5/154 (3%)
Frame = +3
Query: 576 PHLVAVRERVRLNG-----RVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAY 740
P L + E +R+ G + I+EDMF +YF +V + L ++ +P+Y L ++A+
Sbjct: 290 PSLAGMSEWLRILGHSIDNQPITEDMFERYFFEVWECLTSSEIAR--LPRYLQLLALLAF 347
Query: 741 NIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGI 920
+ F+KE VD AI E GG D TN++ K V GIT+LG+DH S LG TI++IA KAG+
Sbjct: 348 HTFVKENVDAAIFETHHGGEYDATNVISKPVVTGITSLGMDHISQLGPTIEDIAWHKAGV 407
Query: 921 MKRGCEAYTVQQPNEAMDVLIQYADSLKCPLTXV 1022
K G A+++ Q + VL + A LT V
Sbjct: 408 FKTGTPAFSILQEDGLRAVLEKRAAEKGVSLTFV 441
>UniRef50_Q9HZA8 Cluster: Folylpolyglutamate synthetase; n=18;
Pseudomonadaceae|Rep: Folylpolyglutamate synthetase -
Pseudomonas aeruginosa
Length = 429
Score = 101 bits (243), Expect = 3e-20
Identities = 58/152 (38%), Positives = 86/152 (56%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
VV V GT GKGST A+ +LR G G YSSPHL+ ERVR++G + F
Sbjct: 44 VVTVTGTNGKGSTCALLAELLREQGLSVGVYSSPHLLRYNERVRIDGIEAGDAQLCDAFS 103
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V + + E + YF T+ A+ +F + +D A++EVG+GG +D N++ +
Sbjct: 104 AV-----EAARGEISL-TYFEMGTLAAFWLFERAGLDFAVLEVGLGGRLDAVNLI-DADL 156
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
IT++GLDH LG+T + +A KAGI++ G
Sbjct: 157 ALITSIGLDHADWLGDTRESVAFEKAGILRAG 188
>UniRef50_Q14PS6 Cluster: Hypothetical folylpolyglutamate synthase
transmembrane protein; n=1; Spiroplasma citri|Rep:
Hypothetical folylpolyglutamate synthase transmembrane
protein - Spiroplasma citri
Length = 374
Score = 101 bits (243), Expect = 3e-20
Identities = 49/177 (27%), Positives = 95/177 (53%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
+++ V++V GT GKGS S L + R G ++SP + ER+++N ++I+++
Sbjct: 32 NKIKVINVVGTNGKGSVSNYLHRQLMLNYKRVGLFTSPAFLKHNERIKINNKMINDNDLK 91
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
+ ++ ++ Q +F ++ FL++K+D+AI+E GIGG +D TN+
Sbjct: 92 RIIKEIKGEIKTYQL------TFFEIWVLICIKYFLEQKIDIAIIEAGIGGCLDATNVFN 145
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYAD 995
V +T++ +HT +LGN++ I +K GI K C+ + + + + +Y D
Sbjct: 146 NQLAVLLTSIDYEHTEVLGNSLDSIIQNKVGIAKSNCKLFISASCKKYFNFIAKYHD 202
>UniRef50_Q9UTD0 Cluster: Folylpolyglutamate synthase; n=1;
Schizosaccharomyces pombe|Rep: Folylpolyglutamate
synthase - Schizosaccharomyces pombe (Fission yeast)
Length = 417
Score = 101 bits (243), Expect = 3e-20
Identities = 54/155 (34%), Positives = 87/155 (56%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
+ V +AGT GKGS + + L +TG Y+SPH + R+ + +NG++ SE++F
Sbjct: 22 ESFCAVQIAGTNGKGSICSYIYTSLLQAAIKTGRYTSPHFLEPRDTISINGQIASEEIFN 81
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
+ V +E ++F + F LT A+ F V VA++E G+GG +D TN+
Sbjct: 82 TCWKQV---IEVDRRFRTKATE-FELLTATAFQCFHHSGVRVAVIETGMGGRLDATNVFE 137
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKR 929
+ + I+ + LDH + LGNT++ IA KAGI K+
Sbjct: 138 EPVLSIISRICLDHQAFLGNTLEAIAKEKAGIFKK 172
>UniRef50_Q2G8T0 Cluster: FolC bifunctional protein; n=3;
Sphingomonadales|Rep: FolC bifunctional protein -
Novosphingobium aromaticivorans (strain DSM 12444)
Length = 435
Score = 101 bits (242), Expect = 4e-20
Identities = 63/187 (33%), Positives = 87/187 (46%), Gaps = 8/187 (4%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V HVAGT GKGST IL G + PHLV ER+RL G++I +++ A
Sbjct: 51 VFHVAGTNGKGSTCTYLRYILEAEGLTVHSATKPHLVRYNERIRLAGKLIEDELLADLLK 110
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
+V D + P +F TV + + + D ++E G+GG +D TN++ V
Sbjct: 111 EVLDAGADLE------PSFFEVTTVATFLAYARTPADACVIETGLGGRLDATNVMPTAAV 164
Query: 837 VGITALGLDHTSIL--------GNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYA 992
GI LGLDH + L + IA KA I K G T+ P A D + + A
Sbjct: 165 CGIATLGLDHEAFLLSPEDGVPTEPLARIAFEKASIAKPGVPLVTMAYPPLAADEVARTA 224
Query: 993 DSLKCPL 1013
L PL
Sbjct: 225 ARLGAPL 231
>UniRef50_Q2SJC8 Cluster: Folylpolyglutamate synthase; n=1; Hahella
chejuensis KCTC 2396|Rep: Folylpolyglutamate synthase -
Hahella chejuensis (strain KCTC 2396)
Length = 430
Score = 101 bits (241), Expect = 5e-20
Identities = 59/170 (34%), Positives = 93/170 (54%), Gaps = 2/170 (1%)
Frame = +3
Query: 474 SVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYF 653
+VV +AGT GKGST A E++ G G Y+SPH++ ERVR+NG +S++ F
Sbjct: 44 TVVTIAGTNGKGSTLAAVEALALAAGKTVGAYTSPHILRFNERVRINGVDVSDEALEAAF 103
Query: 654 HDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
V T YF F T++ + +F + ++D+ ++EVG+GG +D NI+
Sbjct: 104 AAVESARGQTAL------TYFEFTTLVGFYLFQQARLDLVLLEVGLGGRLDAVNIVDPDL 157
Query: 834 VVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQ--PNEAMDV 977
V IT++ LDH LG + ++I KAGI++ G ++ P +DV
Sbjct: 158 AV-ITSVDLDHQEWLGESREDIGREKAGILRPGIPLIIAEEAPPTSVVDV 206
>UniRef50_Q1QY39 Cluster: FolC bifunctional protein; n=1;
Chromohalobacter salexigens DSM 3043|Rep: FolC
bifunctional protein - Chromohalobacter salexigens
(strain DSM 3043 / ATCC BAA-138 / NCIMB13768)
Length = 437
Score = 101 bits (241), Expect = 5e-20
Identities = 58/154 (37%), Positives = 85/154 (55%), Gaps = 2/154 (1%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ VAGT GKGST AM E++ R HG RT Y+SPHL+ ER+RL G + + F
Sbjct: 47 VITVAGTNGKGSTVAMLEAVAREHGLRTAAYTSPHLLRYNERLRLAGCEADDAALVEGFE 106
Query: 657 DVHQRLEDTQKFEGD--MPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKV 830
V + + +GD YF T+ A + + + DVA++EVG+GG +D N++
Sbjct: 107 AV-----EAARLDGDPVTLTYFEAGTLAALWLIARWQPDVALLEVGLGGRLDAVNVI-DP 160
Query: 831 PVVGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
V +T + DH + LG + I KAGI++ G
Sbjct: 161 DVAVVTTVAQDHAAFLGTHLDTIGREKAGILRAG 194
>UniRef50_A6QBX4 Cluster: Folylpolyglutamate synthase; n=1;
Sulfurovum sp. NBC37-1|Rep: Folylpolyglutamate synthase
- Sulfurovum sp. (strain NBC37-1)
Length = 388
Score = 101 bits (241), Expect = 5e-20
Identities = 63/182 (34%), Positives = 99/182 (54%), Gaps = 4/182 (2%)
Frame = +3
Query: 462 LDELSVVHVAGTKGKGSTSAMCESIL-RHHGFRTGFYSSPHLVAVRERVRLNGRVISEDM 638
+D VHV GT GKGST M + + G G +SSPH++ ER+ +NG S+++
Sbjct: 36 IDRPKTVHVVGTNGKGSTGRMISHLAYQGAGLSVGHFSSPHILKFNERIWMNGSDASDEV 95
Query: 639 FAKYFHDVHQRLEDT--QKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYT 812
HQ+L +K + YF + T++A+ +F E D+ ++E G+GG D T
Sbjct: 96 LEA----AHQKLFAILGEKMSHAL-SYFEYTTLLAFVVF--ENCDLMVLEAGLGGEFDAT 148
Query: 813 NILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQP-NEAMDVLIQY 989
N+ K V IT +G+DH LG++I+EIAA+K ++ G + QP E ++V Q
Sbjct: 149 NVCDKELSV-ITPIGIDHQVFLGDSIEEIAATKIRSIQSGAKVLIAPQPYEEVVEVAAQI 207
Query: 990 AD 995
A+
Sbjct: 208 AE 209
>UniRef50_A4CD05 Cluster: Bifunctional: folylpolyglutamate synthase;
dihydrofolate synthase; n=3; Alteromonadales|Rep:
Bifunctional: folylpolyglutamate synthase; dihydrofolate
synthase - Pseudoalteromonas tunicata D2
Length = 423
Score = 101 bits (241), Expect = 5e-20
Identities = 63/175 (36%), Positives = 95/175 (54%), Gaps = 5/175 (2%)
Frame = +3
Query: 417 DMENYLSRTGVTMSKLDELS----VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHL 584
++E L+R K+ LS ++ +AGT GKG+T+ E++L F G Y+SPHL
Sbjct: 26 NIEMGLTRVTAVAEKMGLLSLKSKIILIAGTNGKGTTARCLEALLLAQNFTVGTYASPHL 85
Query: 585 VAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEK 761
+ ERVRLNG+ + + F + +K GD+ YF F T+ A IF +
Sbjct: 86 IKYNERVRLNGQQLDDHYHVAAFAAL-------EKGRGDISMTYFEFGTLGALEIFRHTE 138
Query: 762 VDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
D ++EVG+GG +D TNI+ + V IT + LDH LG+T + + KAGI +
Sbjct: 139 PDFILLEVGLGGRLDATNIVTPIASV-ITTIDLDHKEYLGDTRELVGFEKAGIFR 192
>UniRef50_Q9X7F5 Cluster: FolC protein; n=1; Methylobacterium
chloromethanicum|Rep: FolC protein - Methylobacterium
chloromethanicum
Length = 467
Score = 100 bits (240), Expect = 6e-20
Identities = 59/175 (33%), Positives = 88/175 (50%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+HVAGT GKGS A+ ++L G R Y+SPHLV ER+RL S +
Sbjct: 65 VIHVAGTNGKGSAIAVMRTLLEAGGLRVHTYTSPHLVHFNERIRLASINASRPVADDVLE 124
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
+ + + G F +T A+++F DV ++E G+GG D TN++ K
Sbjct: 125 NALMYCLECNR--GRPITQFEVVTAAAFHMFATHDADVVLLEAGLGGRCDATNVVPKPVA 182
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSL 1001
IT++ DH + LG++I++IA KAGI + G Q + +I A SL
Sbjct: 183 TVITSISYDHETYLGSSIEQIAVEKAGIFRPGIPVIVGPQQYFVAENVISRAASL 237
>UniRef50_A7DJF5 Cluster: FolC bifunctional protein; n=1;
Methylobacterium extorquens PA1|Rep: FolC bifunctional
protein - Methylobacterium extorquens PA1
Length = 390
Score = 100 bits (240), Expect = 6e-20
Identities = 59/149 (39%), Positives = 78/149 (52%), Gaps = 4/149 (2%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRL----NGRVISEDMFA 644
V+HVAGT GKGST A +IL G Y+SPHLV ER+RL G ++ED A
Sbjct: 43 VIHVAGTNGKGSTIAFMRAILEAGGLAAHVYTSPHLVRFHERIRLGGIGGGHYVAEDRLA 102
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
D R E K GD F T A +F + DV ++EVG+GG VD TN++
Sbjct: 103 ----DAFARCEAANK--GDPITVFEITTAAALLLFSECPADVLLLEVGLGGRVDATNVID 156
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASK 911
+T +G DH LG+T++ +A K
Sbjct: 157 HPACAVVTPIGRDHAEYLGDTVEAVAMEK 185
>UniRef50_Q59S44 Cluster: Putative uncharacterized protein; n=2;
Saccharomycetales|Rep: Putative uncharacterized protein -
Candida albicans (Yeast)
Length = 430
Score = 100 bits (240), Expect = 6e-20
Identities = 61/194 (31%), Positives = 101/194 (52%), Gaps = 13/194 (6%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+H+AGT GKGST A S+L + G ++SPH++ + + +N + + F +
Sbjct: 27 IHIAGTNGKGSTLAYISSVLTEAKIKNGKFTSPHIINYHDCISINNQTYPKSKFDRINQQ 86
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNIL------ 821
V ++ + E F LT A+ IF E++++A+VEVG+GG +D TN+L
Sbjct: 87 V-IKINNDLNLE---CTEFEILTATAFKIFALEEIEMALVEVGVGGRLDATNVLIPYGET 142
Query: 822 -----RKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEA--MDVL 980
V IT +GLDH +LG T+ IA K+GI+K G + V N++ + +
Sbjct: 143 IGTSKGGVVATAITKIGLDHEKLLGGTLLAIAKEKSGIIKYGIPCF-VDSSNDSIVLQAI 201
Query: 981 IQYADSLKCPLTXV 1022
+ + + CPL+ V
Sbjct: 202 REKSREVSCPLSVV 215
>UniRef50_UPI0000E0E8A2 Cluster: FolC bifunctional protein; n=1;
alpha proteobacterium HTCC2255|Rep: FolC bifunctional
protein - alpha proteobacterium HTCC2255
Length = 425
Score = 100 bits (239), Expect = 8e-20
Identities = 59/177 (33%), Positives = 98/177 (55%), Gaps = 3/177 (1%)
Frame = +3
Query: 471 LSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKY 650
++V+ VAGT GKG+T A E+ G+ G YSSPH+ ERVR+N +++ + +
Sbjct: 45 VTVITVAGTNGKGTTCAFIEAAAIQCGYEVGVYSSPHINTYNERVRINQQLLDDTAHTQA 104
Query: 651 FHDVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRK 827
F + + G++ YF F T+ + ++ +DVA++EVG+GG +D N++
Sbjct: 105 FAAI-------EAARGNISLTYFEFGTLAGLWLLHQQALDVAVLEVGLGGRLDAINVV-D 156
Query: 828 VPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAY--TVQQPNEAMDVLIQYA 992
+ IT++GLDH + LG+T IA KAGIM+ G + P+ + ++ YA
Sbjct: 157 PDIAVITSIGLDHQAFLGDTRALIAQEKAGIMRAGKPVIIGEPEPPHTLREAVVSYA 213
>UniRef50_UPI000023EB67 Cluster: hypothetical protein FG10379.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG10379.1 - Gibberella zeae PH-1
Length = 686
Score = 100 bits (239), Expect = 8e-20
Identities = 70/224 (31%), Positives = 108/224 (48%), Gaps = 8/224 (3%)
Frame = +3
Query: 345 QSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAM 524
Q K + +I + ++ G++ D+ L R + + E +HVAGT GKGS
Sbjct: 5 QEIKFALSRINRVLK-GKRTAGYRDIRLGLDRIKRVVPQKQEWKGIHVAGTNGKGSICTF 63
Query: 525 CESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA---KYFHDVHQRLEDTQKFE 695
++ + G G ++SP V +NG ++ M+ ++ D QR+ ++
Sbjct: 64 LAALFKLAGLGYGSFTSPAFPERHNGVIINGLYVNRRMYEMEMQHVEDRWQRVATGWTYQ 123
Query: 696 G-DMPKY---FAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLD 863
D PK F T A+ +F K V IVEVG+GG D TN +++ V I+ +GLD
Sbjct: 124 HLDDPKGLSPFEAETATAFRVFNKMHVPYGIVEVGMGGATDATNAMKRKAVTIISKIGLD 183
Query: 864 HTSILGNTIQEIAASKAGIMKRGCEAYTVQ-QPNEAMDVLIQYA 992
H LGNTI+ IA KAGIM++ P + VL Q+A
Sbjct: 184 HQEYLGNTIENIAKVKAGIMRKNVPCIVDHTNPPSVIHVLRQHA 227
>UniRef50_A3S1I7 Cluster: Folylpolyglutamate synthase; n=1;
Prochlorococcus marinus str. MIT 9211|Rep:
Folylpolyglutamate synthase - Prochlorococcus marinus
str. MIT 9211
Length = 413
Score = 100 bits (239), Expect = 8e-20
Identities = 57/172 (33%), Positives = 90/172 (52%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
+E+ + V GT GKGS + ES L+ + G +SPHLV+ RER+R+NG+ IS F
Sbjct: 43 NEIPAIQVIGTNGKGSIVSFLESCLKEARIKIGCSTSPHLVSWRERIRINGQEISSQDFL 102
Query: 645 KYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
K + + + K P F + + A++ F +V++ ++EVG+GG +D T
Sbjct: 103 K----ILTKFQAIAKSYRLTP--FELIILSAFDYFYSNQVELMVLEVGLGGKLDATTAHP 156
Query: 825 KVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVL 980
P++ I +GLDH LGNT+ I KA ++ G + Q E V+
Sbjct: 157 FRPLIAIGGIGLDHCEYLGNTLTAITKEKAAVISYGSTVISSPQEPEVKRVI 208
>UniRef50_A1AXP8 Cluster: FolC bifunctional protein; n=3;
Bacteria|Rep: FolC bifunctional protein - Ruthia
magnifica subsp. Calyptogena magnifica
Length = 404
Score = 100 bits (239), Expect = 8e-20
Identities = 65/184 (35%), Positives = 94/184 (51%), Gaps = 2/184 (1%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ VAGT GKGST+A I + F+ +SSPH++ ER +N +++ F+
Sbjct: 45 VITVAGTNGKGSTAAFINGIYQQSNFKVAKFSSPHILKYNERFVINDAQATDEQICSAFN 104
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
+ Q T YF F T+ A IF EKV++AI+EVG+GG +D NI+ V
Sbjct: 105 KIEQIRGKTTL------TYFEFSTLAALIIFELEKVNIAILEVGLGGRLDSVNIVDN-DV 157
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRG--CEAYTVQQPNEAMDVLIQYADSLKCP 1010
IT + +DH LG+T + I KAGIM++ C + P + QYA +K
Sbjct: 158 SIITNIDIDHVDYLGDTRELIGFEKAGIMRKNIPCICADINPPAS----ISQYAHQIKAQ 213
Query: 1011 LTXV 1022
L V
Sbjct: 214 LEFV 217
>UniRef50_Q5KCY2 Cluster: Dihydrofolate synthase, putative; n=1;
Filobasidiella neoformans|Rep: Dihydrofolate synthase,
putative - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 536
Score = 99 bits (238), Expect = 1e-19
Identities = 62/179 (34%), Positives = 99/179 (55%), Gaps = 7/179 (3%)
Frame = +3
Query: 405 TNLEDMENYLSRTGVTMSKLDELSV--VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSP 578
T L +++ L R + +S L V +H+AGT GKGS SA+ ES GFR Y+SP
Sbjct: 48 TGLGEIDLGLLRMQILISAFPPLLVPAIHLAGTNGKGSVSALLESCFLSAGFRVARYNSP 107
Query: 579 HLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEG---DMPKYFAFLTVMAYNIF 749
HL+ R+ +R++G +E + + V + ++ +K ++ A+ + +
Sbjct: 108 HLLEPRDALRIDGLPPTEGQWEEAVRIV-KEIDKERKVGATVFEITTAAAYWLIYNTTTW 166
Query: 750 LKEKVDVAIVEVGIGGLVDYTNILRKVPVV--GITALGLDHTSILGNTIQEIAASKAGI 920
K VDV I+E G+GG D TN++R V+ +T++GLDHT+ LG T++EI KA I
Sbjct: 167 CKGGVDVMIIECGMGGARDATNVIRADTVLASALTSVGLDHTAFLGETVEEITKEKASI 225
>UniRef50_Q12P54 Cluster: FolC bifunctional protein; n=6;
Shewanella|Rep: FolC bifunctional protein - Shewanella
denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Length = 448
Score = 99.5 bits (237), Expect = 1e-19
Identities = 62/183 (33%), Positives = 97/183 (53%), Gaps = 1/183 (0%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ VAGT GKG++ AM ES+L G R G YSSPHL+ ERVR+ G S++ F
Sbjct: 68 VITVAGTNGKGTSCAMLESVLSFAGKRVGVYSSPHLIHYNERVRIQGVDASDEALIAAFS 127
Query: 657 DVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
+ + G + +F + T+ +F K+DV I+EVG+GG +D TN++
Sbjct: 128 AI-------EAARGAISLTFFEYATLAGLWLFKAAKLDVIILEVGLGGRLDATNMI-DAD 179
Query: 834 VVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
+ +T++ LDH LG+T + + KAG+ R + +P + V YA+ + P+
Sbjct: 180 ICLLTSIALDHQEYLGDTREAVGREKAGVF-RANRLAVIGEPALPITV-TDYAEQIGTPV 237
Query: 1014 TXV 1022
V
Sbjct: 238 CRV 240
>UniRef50_Q9PC39 Cluster: Folylpolyglutamate synthase/dihydrofolate
synthase; n=13; Proteobacteria|Rep: Folylpolyglutamate
synthase/dihydrofolate synthase - Xylella fastidiosa
Length = 441
Score = 99.1 bits (236), Expect = 2e-19
Identities = 56/147 (38%), Positives = 84/147 (57%)
Frame = +3
Query: 486 VAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVH 665
V GT GKGST ESI R G++ G Y+SPHL+ ERVR++GR + + + + F V
Sbjct: 57 VGGTNGKGSTVTFIESIARAAGWKVGTYTSPHLMRYNERVRIDGREVDDALLVEAFSRVE 116
Query: 666 QRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGI 845
+T+ +F F T+ A +F + +D+AI+EVG+GG +D N++ V I
Sbjct: 117 VARRETEL------TFFEFGTLAALWLFSRVVLDLAILEVGLGGRLDAVNLV-DGDVAVI 169
Query: 846 TALGLDHTSILGNTIQEIAASKAGIMK 926
T + +DHT LG + I KAGI++
Sbjct: 170 TTVDIDHTERLGGDREAIGKEKAGIIR 196
>UniRef50_Q7TU62 Cluster: Putuative bifunctional
Dihydrofolate/Folylpolyglutamate synthase; n=5;
Prochlorococcus marinus|Rep: Putuative bifunctional
Dihydrofolate/Folylpolyglutamate synthase -
Prochlorococcus marinus subsp. pastoris (strain CCMP
1378 / MED4)
Length = 410
Score = 99.1 bits (236), Expect = 2e-19
Identities = 60/193 (31%), Positives = 101/193 (52%), Gaps = 4/193 (2%)
Frame = +3
Query: 414 EDMENYLSRTGVTMSKLDE----LSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPH 581
E+++ LSR + LD+ + + + GT GKGS +A E+IL G +SPH
Sbjct: 19 ENIQLGLSRIKNALRDLDDPCKNIPAIQIVGTNGKGSITAFIENILYADKKNIGVTTSPH 78
Query: 582 LVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEK 761
L+ + ER+R+N IS++ F + F + L T K F + A N F +K
Sbjct: 79 LLDICERIRVNKEKISKEEFERLFKKIKNNLS-THKLSP-----FEQIICCALNFFDFKK 132
Query: 762 VDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEA 941
VD+ I+E G+GG +D T P++ I +GLDH LG++I++IA K ++++
Sbjct: 133 VDLLILEAGLGGRLDATTAHPLRPIIAIGNIGLDHKEYLGDSIEKIAKEKVAVIEKNAFV 192
Query: 942 YTVQQPNEAMDVL 980
+ +Q E +++
Sbjct: 193 ISCRQEAEVEEII 205
>UniRef50_Q21IZ3 Cluster: FolC bifunctional protein; n=1;
Saccharophagus degradans 2-40|Rep: FolC bifunctional
protein - Saccharophagus degradans (strain 2-40 / ATCC
43961 / DSM 17024)
Length = 427
Score = 99.1 bits (236), Expect = 2e-19
Identities = 58/170 (34%), Positives = 90/170 (52%), Gaps = 2/170 (1%)
Frame = +3
Query: 474 SVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYF 653
+V+ VAGT GKGS CE++L G G ++SPH++ ER+R++G +S+ + F
Sbjct: 42 TVITVAGTNGKGSFVRSCEAMLGASGMHFGSFTSPHILEYNERIRVDGVDLSDGLICDVF 101
Query: 654 HDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVP 833
+ + +T YF F + A F K D ++EVG+GG +D NI+
Sbjct: 102 AQIDEARGNTSL------TYFEFGALAALLAFHKSNCDYWVLEVGLGGRLDAVNIV-DAD 154
Query: 834 VVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQ--PNEAMDV 977
IT++GLDH + LGNT++ I KAGI++ A + P+ DV
Sbjct: 155 FAVITSVGLDHEAWLGNTVEVIGREKAGILRANQTAVLASKDLPDSVFDV 204
>UniRef50_A5EVX7 Cluster: Folylpolyglutamate synthase; n=1;
Dichelobacter nodosus VCS1703A|Rep: Folylpolyglutamate
synthase - Dichelobacter nodosus (strain VCS1703A)
Length = 422
Score = 98.7 bits (235), Expect = 3e-19
Identities = 56/179 (31%), Positives = 93/179 (51%), Gaps = 1/179 (0%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
++ VAGT GKGS A E+I HG ++SPH++ RER+R N ++ E F
Sbjct: 48 IITVAGTNGKGSCVAWVEAICLAHGISVASFTSPHVIDYRERIRFNDHMVRETELCAAFE 107
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
+ R T +F + + A+ + + +A++EVG+GG +D N+L V
Sbjct: 108 AI-DRARGTITL-----TFFEWSALAAFYLMAQRPPHIAVLEVGLGGRLDAVNLLDADAV 161
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMK-RGCEAYTVQQPNEAMDVLIQYADSLKCP 1010
+ + +GLDHT LG+ I +IAA KAG+++ + A +QP + ++ + CP
Sbjct: 162 I-FSRIGLDHTDWLGDHIDKIAAEKAGVLRAKQWVAMAAEQPTNVLADAVKRMQAQLCP 219
>UniRef50_A1WY03 Cluster: FolC bifunctional protein; n=1;
Halorhodospira halophila SL1|Rep: FolC bifunctional
protein - Halorhodospira halophila (strain DSM 244 /
SL1) (Ectothiorhodospirahalophila (strain DSM 244 /
SL1))
Length = 434
Score = 98.7 bits (235), Expect = 3e-19
Identities = 58/160 (36%), Positives = 85/160 (53%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
VV V GT GKGS + E++LR G T Y+SPH ER+RL+G +++ K
Sbjct: 53 VVTVGGTNGKGSVARTLEALLRGLGVSTALYTSPHFQRFNERMRLDGVEVADAPLVKAL- 111
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
R+E+ + YF T+ A+++F + V I+EVG+GG +D N + V
Sbjct: 112 ---GRVEEARGDADVSLTYFEHTTLAAFDLFARSGARVWILEVGLGGRLDAVNAI-DADV 167
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQ 956
+T + DH LG+ +Q IAA KAGI ++G A QQ
Sbjct: 168 AVVTRIARDHAEFLGDDLQAIAAEKAGIFRKGRPAVIGQQ 207
>UniRef50_A0YB05 Cluster: FolC bifunctional protein; n=1; marine
gamma proteobacterium HTCC2143|Rep: FolC bifunctional
protein - marine gamma proteobacterium HTCC2143
Length = 428
Score = 98.7 bits (235), Expect = 3e-19
Identities = 55/158 (34%), Positives = 88/158 (55%), Gaps = 1/158 (0%)
Frame = +3
Query: 462 LDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMF 641
LD V+ VAGT GKGST A+ ++LR G+ ++SPH + ER++L+ +S+ +
Sbjct: 39 LDRSKVITVAGTNGKGSTVAVLNTLLRSAGYSVACFTSPHFLRYNERIKLDDCDVSDQLL 98
Query: 642 AKYFHDVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNI 818
+ F + Q G +P +F F T+ A +I DV ++EVG+GG +D NI
Sbjct: 99 IESFDRIDQA-------RGTIPLTFFEFGTLAAIDICQHHNADVILLEVGLGGRLDAVNI 151
Query: 819 LRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRG 932
+ + IT++ +DH LG+ ++I KAGIM+ G
Sbjct: 152 I-DADIAVITSIDIDHEDWLGSDREQIGREKAGIMRSG 188
>UniRef50_UPI0000E88026 Cluster: folylpolyglutamate synthetase; n=1;
Methylophilales bacterium HTCC2181|Rep:
folylpolyglutamate synthetase - Methylophilales
bacterium HTCC2181
Length = 423
Score = 98.3 bits (234), Expect = 3e-19
Identities = 56/160 (35%), Positives = 85/160 (53%), Gaps = 2/160 (1%)
Frame = +3
Query: 468 ELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAK 647
+ ++ V GT GKGS A ESIL + G Y+SPHL+ ER+R+N + +
Sbjct: 45 DFPIILVGGTNGKGSVCAFIESILHASDLKIGCYTSPHLLRFNERIRINKHEVDDKA--- 101
Query: 648 YFHDVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILR 824
+ L+ ++ D+P YF T+ A E VD+AI+EVG+GG +D NI
Sbjct: 102 ----IVNALDHIERSRRDIPLTYFEITTLAAVKCMNDEAVDIAILEVGLGGRLDAVNIFS 157
Query: 825 KVPVVG-ITALGLDHTSILGNTIQEIAASKAGIMKRGCEA 941
P + IT + LDH + LG+++ +I K+GI +R A
Sbjct: 158 --PTISLITTVSLDHQAYLGDSVDKIGFEKSGIFRRNIPA 195
>UniRef50_Q2JDQ6 Cluster: FolC bifunctional protein; n=2;
Frankia|Rep: FolC bifunctional protein - Frankia sp.
(strain CcI3)
Length = 445
Score = 98.3 bits (234), Expect = 3e-19
Identities = 64/192 (33%), Positives = 100/192 (52%)
Frame = +3
Query: 357 STIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESI 536
+T++ ++ + G+ +L+ M R G + ++H+ GT GK ST+ + ++
Sbjct: 20 NTVDLEKQTMPAGRPVPSLDRMRELAGRLG---DPHRAVPLIHLTGTNGKTSTARIISAL 76
Query: 537 LRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYF 716
L G R G Y+SPHL V ER+ ++GR I ++ F + V L+ G P +F
Sbjct: 77 LGAAGLRVGLYTSPHLERVNERLVVDGRPIGDEEFGRCVGTV---LDAAAPMSG-RPTFF 132
Query: 717 AFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQE 896
LT A+ F VDVA+VEVG+ G D TNI V +T++G DH G ++
Sbjct: 133 ELLTATAFRWFADLAVDVAVVEVGLLGRWDATNI-ADGRVAVVTSIGADHLDYAG-SMAG 190
Query: 897 IAASKAGIMKRG 932
+A KAGI+K G
Sbjct: 191 VAREKAGIVKPG 202
>UniRef50_Q1JHI7 Cluster: Folylpolyglutamate synthase /
Dihydrofolate synthase; n=15; Streptococcus|Rep:
Folylpolyglutamate synthase / Dihydrofolate synthase -
Streptococcus pyogenes serotype M2 (strain MGAS10270)
Length = 430
Score = 98.3 bits (234), Expect = 3e-19
Identities = 59/176 (33%), Positives = 93/176 (52%), Gaps = 2/176 (1%)
Frame = +3
Query: 465 DELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFA 644
D+ +HV GT GKGS +A + IL G++ G ++SP +++ +R+ LNG+ IS+ A
Sbjct: 45 DKFPAIHVVGTNGKGSVTAYLQHILSTSGYQVGTFTSPFIISFHDRICLNGQPISDLELA 104
Query: 645 KYFHDVHQRL-EDTQKFEGDMPKYFAFLTVMAYNIFLKEK-VDVAIVEVGIGGLVDYTNI 818
+ + L + + + D P F +T++ + F K VD+AI+E GIGG D TN+
Sbjct: 105 QCVSVIRPILTKMSLETNWDRPTEFELVTLIMFCYFANLKPVDIAIIEAGIGGKTDATNV 164
Query: 819 LRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQ 986
+ VV ++ DH LG ++ EIA KA ++K Q EA V Q
Sbjct: 165 FHALAVV-CPSISFDHQERLGYSLAEIAHQKAEVIKAKEPVIIGQLEQEASQVFQQ 219
>UniRef50_Q7VAS8 Cluster: Folylpolyglutamate synthase; n=3;
Prochlorococcus marinus|Rep: Folylpolyglutamate synthase
- Prochlorococcus marinus
Length = 411
Score = 97.5 bits (232), Expect = 6e-19
Identities = 57/190 (30%), Positives = 98/190 (51%)
Frame = +3
Query: 411 LEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVA 590
L+ ++N L + G K+ + +AGT GKGS + ES L +TG +SPHLV+
Sbjct: 28 LDRIQNALQKMGNPCHKVP---AIQIAGTNGKGSITCFLESCLTKTHIKTGCTTSPHLVS 84
Query: 591 VRERVRLNGRVISEDMFAKYFHDVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDV 770
ER+R++G++IS + K+ ++V + K E P F + A+N F +V++
Sbjct: 85 WCERIRIDGQMISPEKLRKFVNEV----KLITKSEQLTP--FELVIASAFNYFFVNQVEL 138
Query: 771 AIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTV 950
++EVG+GG +D T P++ + + DH LG ++ +I KA ++ G +
Sbjct: 139 ILLEVGLGGRLDATTAHPWRPIIAMGKISFDHCEYLGESLAKITKEKAAVISYGSHVISA 198
Query: 951 QQPNEAMDVL 980
Q E +L
Sbjct: 199 DQEPEVKKIL 208
>UniRef50_Q49Y95 Cluster: Folylpolyglutamate synthase; n=16;
Staphylococcus|Rep: Folylpolyglutamate synthase -
Staphylococcus saprophyticus subsp. saprophyticus
(strain ATCC 15305 /DSM 20229)
Length = 424
Score = 97.5 bits (232), Expect = 6e-19
Identities = 58/174 (33%), Positives = 89/174 (51%), Gaps = 2/174 (1%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
+HV GT GKGST + S L +G+ G ++SP + ER+ LNG IS+D
Sbjct: 42 IHVGGTNGKGSTVSYLRSALVDNGYEVGTFTSPFIETFNERISLNGNPISDDEIVALVQH 101
Query: 660 VHQRLEDTQ-KFEGDMPKYFAFLTVMAYNIFLK-EKVDVAIVEVGIGGLVDYTNILRKVP 833
V E + + E F +T M + F + VD IVE G+G D TN+ + +
Sbjct: 102 VKPVSEALEIETELGTATEFEIITTMMFLYFGEIHPVDFVIVEAGLGIKNDSTNVFKPIL 161
Query: 834 VVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYAD 995
+ +T++GLDHT +LG+T +IA K I+K + +EA+ V+ Y +
Sbjct: 162 SI-LTSIGLDHTDLLGDTYVDIAKDKGAIVKPNTPVIYAVKNDEALKVIRDYVE 214
>UniRef50_Q2BMN3 Cluster: Folylpolyglutamate synthase; n=1;
Neptuniibacter caesariensis|Rep: Folylpolyglutamate
synthase - Neptuniibacter caesariensis
Length = 419
Score = 97.1 bits (231), Expect = 8e-19
Identities = 58/156 (37%), Positives = 85/156 (54%), Gaps = 1/156 (0%)
Frame = +3
Query: 462 LDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMF 641
L +VV VAGT GKGST + SI G+ G Y+SPH + ERVRLNG +++
Sbjct: 40 LSSSTVVTVAGTNGKGSTVSYLSSIYLQAGYSVGAYTSPHFLRYNERVRLNGLEATDEQL 99
Query: 642 AKYFHDVHQRLEDTQKFEGDMP-KYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNI 818
D +R++ + G +P YF F T+ A IF K D+ ++EVG+GG +D NI
Sbjct: 100 C----DAFERIDQAR---GQIPLTYFEFGTLAALIIFADTKPDLVLLEVGLGGRLDAVNI 152
Query: 819 LRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMK 926
+ V +T + +DH LG+ + I K+GI +
Sbjct: 153 I-DADVSVVTTVSIDHVDWLGDDREFIGHEKSGIFR 187
>UniRef50_A6VWY8 Cluster: FolC bifunctional protein; n=2;
Marinomonas|Rep: FolC bifunctional protein - Marinomonas
sp. MWYL1
Length = 418
Score = 97.1 bits (231), Expect = 8e-19
Identities = 55/151 (36%), Positives = 81/151 (53%)
Frame = +3
Query: 477 VVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFH 656
V+ VAGT GKGST AM L + G Y+SPH +A ER+ LN +++ + F
Sbjct: 44 VITVAGTNGKGSTCAMLTQYLCAQNYSVGTYTSPHFIAFNERIALNDSPCDDEVLCRAFE 103
Query: 657 DVHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPV 836
V + EG YF F T+ A IF + +D ++EVG+GG +D N++ V
Sbjct: 104 VVEEAR------EGISLTYFEFSTLAALWIFDQSNLDYWVLEVGLGGRLDSVNMM-DTDV 156
Query: 837 VGITALGLDHTSILGNTIQEIAASKAGIMKR 929
+T++ LDH LG+ + IA KAGI ++
Sbjct: 157 AVVTSISLDHIDWLGDNLDVIAREKAGIARK 187
>UniRef50_A6DD55 Cluster: Folylpolyglutamate synthetase; n=1;
Caminibacter mediatlanticus TB-2|Rep: Folylpolyglutamate
synthetase - Caminibacter mediatlanticus TB-2
Length = 378
Score = 96.7 bits (230), Expect = 1e-18
Identities = 55/159 (34%), Positives = 88/159 (55%), Gaps = 1/159 (0%)
Frame = +3
Query: 456 SKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISED 635
+K++ V+H+ GT GKGST L G+ G Y+SPH++ ER+ +NG IS++
Sbjct: 34 NKINIPPVIHIVGTNGKGSTGRFLAYTLLKRGYNVGHYTSPHILKFNERIWINGENISDE 93
Query: 636 MFAKYFHDVHQRLEDTQKFE-GDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYT 812
+VH++L+ + + YF + T +A F E +D I+E G+GG D T
Sbjct: 94 K----LEEVHKKLQTLLPTDIINTLSYFEYTTFLAALSF--EGLDFVIMEAGLGGEFDAT 147
Query: 813 NILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKR 929
N+ K + IT + DH + LGNTI+EIA +K +++
Sbjct: 148 NVFPK-KISLITTIDYDHQNFLGNTIEEIATTKLNSIQK 185
>UniRef50_Q72J06 Cluster: Folylpolyglutamate synthase/dihydrofolate
synthase; n=2; Thermus thermophilus|Rep:
Folylpolyglutamate synthase/dihydrofolate synthase -
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM
7039)
Length = 390
Score = 95.9 bits (228), Expect = 2e-18
Identities = 60/178 (33%), Positives = 90/178 (50%)
Frame = +3
Query: 480 VHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLNGRVISEDMFAKYFHD 659
VHV GT GKGS A E+ R G G Y+SPHLV RER+R + + + ++
Sbjct: 41 VHVLGTNGKGSVVAYLEAAFRAAGLAYGAYTSPHLVDFRERIRTHLGPVPREAVVRF--- 97
Query: 660 VHQRLEDTQKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVV 839
V E+ + + P +F T +A+ F + V +A VE G+GG D TN L +V +
Sbjct: 98 VAWAREEAWE---EPPGFFDLATALAFLHFRERGVALAAVEAGVGGEKDATNALSRVALT 154
Query: 840 GITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVQQPNEAMDVLIQYADSLKCPL 1013
+T +G DH LG T++ +A KAG + G T + ++V + A+ PL
Sbjct: 155 VLTNVGEDHLEALGGTLEAVAREKAGAFRPGVPVVTGAR-GVGLEVARKVAEERGAPL 211
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 958,671,767
Number of Sequences: 1657284
Number of extensions: 18582795
Number of successful extensions: 46499
Number of sequences better than 10.0: 300
Number of HSP's better than 10.0 without gapping: 44301
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 46041
length of database: 575,637,011
effective HSP length: 102
effective length of database: 406,594,043
effective search space used: 117505678427
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
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